Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx.
Gooderham
N J
NJ
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, UK.
Murray
B P
BP
Murray
S
S
Boobis
A R
AR
Davies
D S
DS
D000818:Animals; D001711:Biotransformation; D002417:Cattle; D006224:Cricetinae; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006358:Hot Temperature; D006801:Humans; D007408:Intestinal Absorption; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008460:Meat / Q000032:analysis*; D008647:Mesocricetus; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism* / Q000494:pharmacology; D011810:Quinoxalines / Q000378:metabolism* / Q000494:pharmacology; D011817:Rabbits; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D009153:Mutagens; D011810:Quinoxalines; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; D003577:Cytochrome P-450 Enzyme System; D013806:Theophylline; C050131:furafylline