Correlation of gastric mucous volume with levels of five prostaglandins after gastric mucosal injuries by NSAIDs.
After administration of NSAIDs (aspirin and indomethacin), chronological changes in gastric mucous volume were determined. These mucous volume changes were evaluated in relation to the development of gastric mucosal injuries. Furthermore, quantitative changes in five kinds of prostaglandins (PGs) in the gastric mucosa were measured after administration of NSAIDs. Gastric mucus volume was measured using a video image processor (VIP), and five kinds of PGs were fractionated by high-performance liquid chromatography (HPLC) and quantitatively determined by radioimmunoassay (RIA). We found that NSAIDs decrease the levels of five kinds of PGs to the same extent. Also, gastric mucous volume is decreased after administration of aspirin and increased after administration of indomethacin. Accordingly, it is possible that each NSAID has a different mechanism of producing the gastric mucosal injury and acts on gastric mucus in a different manner. There was no parallel in changes between gastric mucous volume and PG levels of the different PGs in the gastric mucosa after administration of NSAIDs.
Asada
S
S
Second Department of Internal Medicine, Osaka Medical College, Japan.
Okumura
Y
Y
Matsumoto
A
A
Hirata
I
I
Ohshiba
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D002851:Chromatography, High Pressure Liquid; D005753:Gastric Mucosa / Q000737:chemistry / Q000187:drug effects*; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D009093:Mucus / Q000737:chemistry* / Q000187:drug effects; D011453:Prostaglandins / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin