Dose-response relationships for topically applied antigens.
Patch-test responses to serially diluted nickel sulphate and potassium dichromate solutions in patients with nickel and chrome sensitivity were assessed by pulsed A-scan ultrasound to determine skin thickness and laser-Doppler flowmeter techniques to evaluate blood flow, as well as clinical scoring. There was a relationship between the dose of antigen and the test responses as measured by ultrasound and laser-Doppler flowmeter techniques in both nickel and chrome sensitive patients. Our data suggest that both techniques may be useful in the detection of allergic contact dermatitis in which there is a doubtful patch-test reaction as well as in experimental sensitization studies.
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Department of Medicine (Dermatology), University of Wales College of Medicine, Cardiff, U.K.
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D002857:Chromium / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007834:Lasers; D009532:Nickel / Q000009:adverse effects*; D010328:Patch Tests; D014463:Ultrasonography
D002857:Chromium; D009532:Nickel