The luteinizing hormone-releasing hormone (LH-RH) system in neonatally estradiol-feminized male gray short-tailed opossums (Monodelphis domestica).
In this study, the luteinizing hormone-releasing hormone (LH-RH) system was examined in adult gray short-tailed opossums that had been treated with estradiol benzoate (EB) on days 1 and 3 of postnatal life, a treatment which results in complete block of testicular development. The finding that the organization of the LH-RH system in neonatally EB-treated males did not differ from that of neonatally untreated animals indicates that the LH-RH system can develop normally despite the absence of gonads throughout perinatal life.
Fadem
B H
BH
Department of Psychiatry, UMDNJ-New Jersey Medical School, Newark 07103.
Schwanzel-Fukuda
M
M
D000818:Animals; D000831:Animals, Newborn; D004958:Estradiol / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism* / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D008473:Median Eminence / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D009893:Opossums / Q000378:metabolism*; D013737:Testis / Q000187:drug effects / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol