Assessment of milk fat globule membrane antibodies and lectins as markers of short-term prognosis in breast cancer.
The milk fat globule membrane antibodies HMFG1, HMFG2, NCRC 11 and four of the Mam 6 series, and the lectins peanut agglutinin, wheat germ agglutinin, Concanavalin A, Lotus tetragonolobus and Ulex europaeus I have been applied to 115 stage I and II breast carcinomas (median follow up = 36 months) to assess their value as prognostic markers. Of the milk fat globule membrane antibodies only NCRC 11 staining showed a relationship to development of recurrent disease and overall survival, but this did not act as an independent indicator over and above that provided by histological grade. None of the lectins gave prognostic information, including those whose binding related to node status or grade. It is concluded that for short-term prognosis none of the markers can given independent prognostic information over and above that provided by histological evaluation.
Department of Pathology, University of Leicester, Leicester Royal Infirmary, UK.
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Walker
D000906:Antibodies; D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000276:immunology; D015415:Biomarkers; D001943:Breast Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D037102:Lectins / Q000096:biosynthesis*; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000276:immunology; D018396:Mucin-1; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016019:Survival Analysis
D000906:Antibodies; D000951:Antigens, Neoplasm; D015415:Biomarkers; D037102:Lectins; D008562:Membrane Glycoproteins; D018396:Mucin-1