Successful treatment of hair cell leukemia with 2'-deoxycoformycin after failure of interferons alpha or beta.
Two patients with hairy cell leukemia (HCL) who failed alpha-2a-interferon and one who failed beta-ser-interferon were treated with 2'-deoxycoformycin (DCF), 4 mg/m2, by intravenous bolus infusion every 2 weeks. All three patients achieved a complete response, continuing for 9+, 14+, and 15+ months. Treatment was discontinued when complete remission was diagnosed. DCF-induced remission has not been previously reported after beta-ser-interferon failure. These patients, as well as 12 others in the literature reviewed herein, demonstrate the efficacy of DCF in HCL patients unresponsive to alpha, beta, and gamma interferon.
Department of Oncology, Montefiore Medical Center, Bronx, New York 10467.
J P
JP
Dutcher
K M
KM
Salva
P H
PH
Wiernik
D000328:Adult; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016898:Interferon-alpha / Q000627:therapeutic use*; D016899:Interferon-beta; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015649:Pentostatin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D015649:Pentostatin; D016899:Interferon-beta; D000068556:Interferon beta-1a