[Presence of specific factors in mother's milk against strains of diarrhea-causing Escherichia coli in humans].
Presence of specific secretory immunoglobulin A (sIgA) against pathogenic factors of Escherichia coli related with diarrheal disease was studied in colostrum and breast-milk samples obtained longitudinally from a cohort of rural Mexican women. Levels of sIgA against heat-labile enterotoxin, Shiga-like toxin, colonization factors antigens I, II and E8775 and adherence to HEp-2 cells were detected in samples obtained from 54 rural women during the first year of lactation. Although production of specific sIgA against these pathogenic factors was almost universal it was not constant, even in the same woman. The results reflect a definite mother-infant relationship during this period. The data support the thesis of using breast-milk as a vaccination vehicle against diarrhea associated with specific organisms during the first year of life of infants born in developing areas of the world.
Cravioto
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Instituto Nacional de Ciencias y Tecnologías-DIF.
D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology; D003126:Colostrum / Q000032:analysis / Q000276:immunology; D003968:Diarrhea, Infantile / Q000209:etiology / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000150:complications / Q000276:immunology*; D005260:Female; D036781:Fimbriae Proteins; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis / Q000276:immunology; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008895:Milk, Human / Q000032:analysis* / Q000276:immunology; D009500:Neutralization Tests
D000942:Antigens, Bacterial; D007071:Immunoglobulin A, Secretory; C022924:colonization factor antigens; D036781:Fimbriae Proteins
Presencia de factores específicos en leche materna contra cepas de Escherichia coli causantes de diarrea en humanos.