The synthesis and antilipidperoxidation activity of 4,4-diarylbutylamines and 4,4-diarylbutanamides.
A series of 4,4-diarylbutylamine and 4,4-diarylbutanamide derivatives has been synthesized and evaluated for their antilipidperoxidation (ALP) activity and acute toxicity (LD50). Some of them were found to have significant ALP activity.
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
S
S
Miyano
T
T
Tatsuoka
K
K
Suzuki
K
K
Imao
F
F
Satoh
T
T
Ishihara
I
I
Hirotsu
T
T
Kihara
M
M
Hatta
Y
Y
Horikawa
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001923:Brain Chemistry / Q000187:drug effects; D002082:Butylamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000577:Amides; D001555:Benzene Derivatives; D002082:Butylamines