Cryptococcal cellulitis in congenital lymphedema.
A 27-year-old woman with intestinal lymphangiectasia and congenital lymphedema developed cryptococcal cellulitis as a result of her underlying depressed cell-mediated immune responsiveness. Prompt therapy with amphotericin B and 5-fluorocytosine resulted in an excellent outcome. The authors believe that the increasing population of patients with depression of cell-mediated immune response will lead to an increase in the frequency with which cryptococcal cellulitis is seen and emphasize that proper evaluation of a patient with presumptive cellulitis includes consideration of fungal, as well as bacterial, etiology.
Department of Dermatology, University of Minnesota Hospital and Clinics, Minneapolis.
N
N
Krywonis
V N
VN
Kaye
P J
PJ
Lynch
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D002481:Cellulitis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D003453:Cryptococcosis; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007231:Infant, Newborn; D008209:Lymphedema / Q000150:complications / Q000151:congenital* / Q000276:immunology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011379:Prognosis
D000666:Amphotericin B; D005437:Flucytosine