[Antibiotherapy in chronic familial granulomatosis].
Antibacterial therapy in chronic granulomatous disease requires antimicrobials active on Staphylococcus aureus and enterobacteria, which also have a good intracellular penetration and activity as rifampicin, fluoroquinolone, fosfomycin, cotrimoxazole. Several trials showed that cotrimoxazole was effective for the prevention of bacterial infection: thus, this antimicrobial can be used as long-term and continuous prophylaxia. Fungal infections require the use of amphotericin B. The place of new imidazole compounds as itraconazole should be assessed.
Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Bichat-Claude-Bernard, Paris.
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Vilde
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Leport
D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D004338:Drug Combinations / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000235:genetics*; D006801:Humans; D009181:Mycoses / Q000150:complications / Q000188:drug therapy; D011292:Premedication; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004338:Drug Combinations; D000666:Amphotericin B; D014295:Trimethoprim; D013420:Sulfamethoxazole
Antibiothérapie au cours de la granulomatose chronique familiale.