Cerebral amyloid in mice with Creutzfeldt-Jakob disease is influenced by the strain of the infectious agent.
We examined Fukuoka-1 and Fukuoka-2 mouse-adapted Creutzfeldt-Jakob disease strains. Mice infected with the Fukuoka-2 strain have a higher incidence of kuru plaques, a higher concentration of proteinase-resistant prion protein, and a higher infectivity titer than do mice with the Fukuoka-1 strain. Thus, it must be kept in mind that there is a difference in the strain of the infectious agent in murine Creutzfeldt-Jakob disease.
Department of Neuropathology, Kyushu University, Fukuoka, Japan.
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Kitamoto
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Yi
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Mohri
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Tateishi
D000686:Amyloidosis / Q000382:microbiology* / Q000473:pathology; D000818:Animals; D001927:Brain Diseases / Q000382:microbiology* / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL