Genetical, developmental, and thermal regulation of antioxidant enzymes in Neurospora.
Three characteristics of the biochemical genetics of antioxidant enzyme regulation in Neurospora and enteric bacteria are analogous. This paper reports two additional analogies:responsiveness to change in respiratory rate or thermal stress. A negative regulatory Neurospora mutant is defective in those responses. Although several differences are noted, the common denominator of the two organisms is probably an oxy-regulon, a global unit of genetic function. The degree of homology of bacterial and fungal antioxidant enzyme regulatory mechanisms at the molecular-genetic and signal transduction levels of organization remains to be examined. The hypothesis that the genetic control of antioxidant enzymes is a prerequisite for cellular differentiation of Neurospora is discussed.
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.
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Munkres
D000975:Antioxidants / Q000378:metabolism*; D002454:Cell Differentiation; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005609:Free Radicals; D006358:Hot Temperature; D008928:Mitochondria / Q000201:enzymology; D009491:Neurospora / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D012475:Salmonella / Q000201:enzymology / Q000235:genetics
D000975:Antioxidants; D005609:Free Radicals; D010088:Oxidoreductases; D010100:Oxygen