Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopic duodenitis.
Thirty dyspeptic patients with endoscopic evidence of mild to moderate (nonerosive) duodenitis were randomly assigned to treatment with 50 mg of pirenzepine twice daily or 2 gm of sucralfate twice daily for four weeks. Posttreatment endoscopy revealed normalization of duodenal mucosa in half of the patients in each treatment group. The severity of dyspeptic symptoms was significantly reduced in both groups, with no significant between-group differences.
Gastroenterology Unit, University of Milan, Italy.
M
M
Guslandi
V
V
Molteni
M
M
Dell'Oca
E
E
Ballarin
D000293:Adolescent; D000328:Adult; D000368:Aged; D015986:Confounding Factors, Epidemiologic; D004311:Double-Blind Method; D004382:Duodenitis / Q000188:drug therapy*; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013392:Sucralfate / Q000627:therapeutic use*
D010890:Pirenzepine; D013392:Sucralfate