Insights into membrane insertion based on studies of colicins.
The recently determined three-dimensional structure of the pore-forming domain of colicin A has led to a hypothetical model for membrane insertion and channel formation. Certain features of this model have implications for understanding the mechanism of membrane insertion by other toxins and may have a broader relevance to protein transport in general.
European Molecular Biology Laboratory, Heidelberg, FRG.
M W
MW
Parker
A D
AD
Tucker
D
D
Tsernoglou
F
F
Pattus
D001692:Biological Transport / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D003087:Colicins / Q000378:metabolism*; D008958:Models, Molecular; D011506:Proteins / Q000378:metabolism; D014118:Toxins, Biological / Q000378:metabolism*
D003087:Colicins; D011506:Proteins; D014118:Toxins, Biological