[Inoculation failure following hepatitis B vaccination. The effect of additional vaccinations].
One to three repeat vaccinations were undertaken in 63 persons (32 males, 31 females; mean age 29 [17-59] years) who had not or inadequately responded to basal immunization with hepatitis B vaccine (47 non- and 16 hyporesponders). After re-vaccination, 12 of the 47 nonresponders and 11 of 16 hyporesponders formed specific antibodies against hepatitis B surface antigen, anti-HBs, at concentrations above 10 IU/l. Six of 14 persons who had not responded to the first repeat vaccination reached anti-HBs concentrations above 10 U/l after a further injection. Vaccination response was age-dependent. The median age of those subjects who responded to the first re-vaccination was 27 (19-45) years, while the non-responders' median age was 34 (22-59) years (P less than 0.05). Re-vaccination also raised initially low anti-HBs values. These results indicate that some of the nonresponders can obtain reliable protection by revaccination(s).
Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Universität München.
W
W
Jilg
M
M
Schmidt
F
F
Deinhardt
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004361:Drug Tolerance; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006801:Humans; D007117:Immunization, Secondary; D007273:Injections, Intramuscular; D008875:Middle Aged; D011863:Radioimmunoassay; D013997:Time Factors; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology*
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines
Impfversagen nach Hepatitis-B-Impfung. Einfluss zusätzlicher Impfungen.