[Incidence of secondary tumors following cervical neoplasia in Saarland 1968-1987].
In 4468 patients diagnosed with invasive cancer or carcinoma in situ of the uterine cervix in Saarland/W-Germany in 1968-1987, 149 secondary cancers were observed compared to 150.6 which would have been expected had the same risk prevailed as in the general population (SMR = 0.99, 95% confidence interval 0.84-1.17). There were, however, substantial differences between the relative risks for specific cancer sites. For example, the risk of breast cancer was clearly lower than in the general population (SMR = 0.62, 95% confidence interval 0.43-0.88), while the risk of cancer of the urinary bladder was significantly increased (SMR = 2.88, 95% confidence interval 1.53-4.93). The results are consistent with findings from other countries, with current knowledge of risk factor profiles of different malignancies and with hypotheses on possible side effects of radiotherapy.
Saarländisches Krebsregister, Statistisches Landesamt, Saarbrücken.
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Brenner
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Stegmaier
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Ziegler
D002278:Carcinoma in Situ / Q000401:mortality* / Q000532:radiotherapy; D002423:Cause of Death; D003430:Cross-Sectional Studies; D005260:Female; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009378:Neoplasms, Multiple Primary / Q000401:mortality*; D009381:Neoplasms, Radiation-Induced / Q000401:mortality; D012042:Registries; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000532:radiotherapy
Untersuchungen zum Auftreten von Zweittumoren nach Zervixneoplasien im Saarland 1968-1987.