The Saccharomyces cerevisiae DNA repair gene RAD2 is regulated in meiosis but not during the mitotic cell cycle.
The expression of the RAD2 gene of Saccharomyces cerevisiae is elevated upon DNA damage. Here, we show that RAD2 transcript levels also rise approximately eightfold during meiosis but remain constant during the mitotic cell cycle. The period of maximal RAD2 mRNA accumulation during meiosis is consistent with a possible role of RAD2 in a late stage of recombination, in mismatch repair of heteroduplexes, or both.
Department of Biology, University of Rochester, New York 14627.
K
K
Madura
S
S
Prakash
D002453:Cell Cycle; D004260:DNA Repair; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D008540:Meiosis; D008938:Mitosis; D012333:RNA, Messenger / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*; D014158:Transcription, Genetic
D012333:RNA, Messenger