Elastic fibre damage induced by low-dose D-penicillamine.
We have studied 23 patients receiving penicillamine for the treatment of rheumatoid arthritis to determine the prevalence of penicillamine-induced elastosis. One female patient had pseudoxanthoma elasticum-like skin changes and bramble-bush elastosis without calcification in the involved skin. Penicillamine elastosis was present in the joint capsule in 62% of eight patients or 64% of II joints examined and was detected in joint capsules after as little as I year of treatment.
Department of Dermatology, Slade Hospital, Oxford, U.K.
K L
KL
Dalziel
S M
SM
Burge
P A
PA
Frith
T J
TJ
Ryan
A
A
Mowat
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology; D004334:Drug Administration Schedule; D004547:Elastic Tissue / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015995:Prevalence; D011561:Pseudoxanthoma Elasticum / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000473:pathology
D010396:Penicillamine