Comparison of an acellular pertussis-component diphtheria-tetanus-pertussis (DTP) vaccine with a whole-cell pertussis-component DTP vaccine in 17- to 24-month-old children, with measurement of 69-kilodalton outer membrane protein antibody.
Healthy 17- to 24-month-old children, previously immunized with three doses of whole-cell diphtheria-tetanus-pertussis (DTP) vaccine, were enrolled in a multi-center double-blind, randomized study comparing a DTP vaccine with an acellular pertussis-component (APDT) and a conventional whole-cell pertussis-component DTP vaccine. Thirty-eight children received APDT vaccine, and 37 children received DTP vaccine. APDT vaccine recipients had significantly less local pain and warmth than DTP vaccine recipients. Antibody responses to lymphocytosis-promoting factor were similar in the two groups. The APDT vaccine recipients had a higher IgG antibody response to filamentous hemagglutinin than the DTP vaccinees had. Equivalent agglutinin responses were seen in the two groups. The APDT vaccine recipients had a significantly better antibody re-enzyme-linked immunosorbent assay, than DTP vaccinees had 1 month and 1 year after immunization. This APDT vaccine was immunogenic and caused fewer local reactions than conventional DTP vaccine when administered as a fourth dose to 17- to 24-month-old children.
Department of Pediatrics, University of California, Los Angeles School of Medicine 90024.
D A
DA
Blumberg
C M
CM
Mink
J D
JD
Cherry
K S
KS
Reisinger
M M
MM
Blatter
B L
BL
Congeni
C L
CL
Dekker
M G
MG
Stout
J R
JR
Mezzatesta
J V
JV
Scott
D000373:Agglutinins / Q000276:immunology; D000907:Antibodies, Bacterial / Q000032:analysis*; D001426:Bacterial Proteins / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007378:Interleukins / Q000276:immunology; D008222:Lymphokines / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D015337:Multicenter Studies as Topic; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D011897:Random Allocation
D000373:Agglutinins; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006388:Hemagglutinins; D007074:Immunoglobulin G; D007378:Interleukins; D008222:Lymphokines; D008565:Membrane Proteins; D010567:Pertussis Vaccine; C043695:lymphocyte proliferation potentiating factors