Hepatic selenium concentration in pigs with microangiopathy (mulberry heart disease)--an animal model for the study of oxidative damage.
The significance of selenium deficiency was investigated in pigs that died suddenly of microangiopathy (MAP, mulberry heart disease). Hepatic selenium concentration (mean +/- SD) in pigs with MAP (1.04 +/- 0.47 micrograms/g dry weight) was lower than in healthy pigs (1.23 +/- 0.53 micrograms/g). The lowest hepatic selenium values were found in pigs with MAP and in 22.2% of MAP pigs hepatic selenium concentration was below 0.5 microgram/g which reflects selenium deficiency. Thus, pigs with a low selenium status are at risk of MAP. The low selenium status together with vitamin E deficiency increases oxidative stress and thus contributes to the development of oxidative damage.
Department of Pathology, College of Veterinary Medicine, Helsinki, Finland.
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Korpela
D000818:Animals; D009202:Cardiomyopathies / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D008099:Liver / Q000378:metabolism; D008833:Microcirculation / Q000473:pathology; D010100:Oxygen / Q000378:metabolism*; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism; D013552:Swine; D014811:Vitamin E Deficiency / Q000150:complications / Q000378:metabolism / Q000473:pathology
D012643:Selenium; D010100:Oxygen