[The interaction of the neuroendocrine and immune systems and the role of the opioid peptides in regulating immune homeostasis].
The data on the central mechanisms of the immune system regulation and the role of opioid peptides in this process are summarized. The fact that the opioid component is involved in the regulation of the system of immunity predetermines the possibility of the influence on the immune system by means of the compounds possessing the opioid activity. This fact and also their low toxicity make the compounds promising for the development on their basis of original immunomodulators devoid of the disadvantages being intrinsic to the available drugs.
B S
BS
Uteshev
S A
SA
Korostelev
D000818:Animals; D004723:Endorphins / Q000494:pharmacology / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000276:immunology; D009490:Neurosecretory Systems / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D004723:Endorphins
Vzaimodeĭstvie neĭroéndokrinnoĭ i immunnoĭ sistem i rol' opioidnykh peptidov v reguliatsii immunnogo gomeostaza.