Effect of intraocular aspiration of sodium hyaluronate on postoperative intraocular pressure.
A prospective, randomized, masked study was conducted to evaluate whether intraocular aspiration of sodium hyaluronate used in cataract surgery influenced postoperative intraocular pressure (IOP). Ninety-nine patients (105 eyes) underwent uncomplicated extracapsular extractions with posterior chamber intraocular lens implantation using 1% sodium hyaluronate (AMVISC). In 53 eyes, sodium hyaluronate was aspirated from the anterior chamber prior to wound closure. Sodium hyaluronate was left in the anterior chamber of 52 eyes. The IOP of 33 of the patients was measured 4 hours after surgery. No significant difference was found between the pressure in the eyes from which the sodium hyaluronate had been aspirated and the pressure in those from which it had not. The IOP of all the patients was measured on the first postoperative day. The mean 24 hours after surgery was 23.4 mm Hg in the aspirated eyes and 23.1 mm Hg in the not-aspirated group. Thirteen eyes in the aspirated group and 14 in the not-aspirated group had pressures above 30 mm Hg during the first 24 hours after surgery. There were no significant differences in visual outcome, patient discomfort, corneal clarity, anterior chamber inflammation, or subsequent IOPs during 3 months postoperative examination. Aspiration of sodium hyaluronate at the end of cataract surgery does not appear to significantly reduce either the incidence or the degree of postoperative pressure elevations.
Department of Ophthalmology, Pacific Presbyterian Medical Center, San Francisco, CA 94115.
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Stamper
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DiLoreto
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Schacknow
D000368:Aged; D002387:Cataract Extraction; D004311:Double-Blind Method; D004322:Drainage; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D007910:Lenses, Intraocular; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D014792:Visual Acuity
D006820:Hyaluronic Acid