[Microbial ecosystems of the skin in antimicrobial therapy].
Healthy human skin provides wet, dry, and sebaceous habitats for well-adapted microbes living in a community and occupying three-dimensional spaces of the skin. These resident microbes of the skin are reduced either intentionally or unintentionally under systemic or topical antimicrobial therapy, e.g. in acne or tinea versicolor. As a result, quantitative or qualitative alterations of the microbial communities might ensue, including the selection of multiresistent variants in a habitat or a total change of the microbial community followed by the so-called gram-negative folliculitis. Skin disinfectants are antimicrobially effective within 30 to 60 seconds. Their long-term efficacy varies according to the specific substance. Moreover, the antimicrobial efficacy of skin disinfectants may vary to a considerable degree in the individual habitats of the human skin.
Klinik und Poliklinik für Haut- und Geschlechtskrankheiten, Bayerischen Julius-Maximilians-Universität Würzburg.
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Röckl
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Hartmann
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects; D006801:Humans; D012867:Skin / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents
Mikrobenökosysteme der Haut unter antimikrobieller Therapie.