Drug-induced changes of plasma gastrin concentration.
There is a significant inverse relationship between intragastric acidity and plasma gastrin concentration. All generally available gastric acid antisecretory drugs induce a release of gastrin into the circulation. The more potent the gastric antisecretory dosage regimen or drug, the greater the rise of plasma gastrin concentration. The drug-induced rise of plasma gastrin concentration is of no direct clinical concern, although it may be partly responsible for the phenomenon of tolerance to H2-blockade. Drug-induced hypergastrinemia could stimulate the proliferation of certain cell lines associated with the gastrointestinal tract, for example, the gastric epithelium, ECL cells, or colonic neoplasms.
Academic Division of Clinical Sciences, Royal Free Hospital School of Medicine, London, England.
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Pounder
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Smith
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002169:Campylobacter Infections / Q000188:drug therapy; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000009:adverse effects / Q000097:blood* / Q000187:drug effects*; D005756:Gastritis / Q000188:drug therapy; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D006801:Humans
D005755:Gastrins