Polyunsaturates, endogenous eicosanoids, and cardiovascular disease.
The role of dietary polyunsaturated fats in the prevention of human vascular disease has not been defined, but population and intervention studies have suggested that omega-3 fatty acids (FAs) from marine lipids may have a number of potentially beneficial effects. Eicosanoids are extremely potent autacoids made from polyunsaturated fatty acids and have effects on many vascular parameters, so that the physiological effects of dietary supplementation with polyunsaturated fats are often attributed to alterations in endogenous eicosanoid production. Few studies have attempted to correlate in vivo eicosanoid synthesis and functional effects during such dietary maneuvers, however. This article reviews the relationship between dietary polyunsaturates and endogenous eicosanoid synthesis in man, with particular emphasis on recent studies of the effects of omega-3 FAs. Data on omega-3 FAs and platelet-vascular interactions, blood pressure, and vascular reactivity in human subjects are also summarized, with interpretation of recent work addressing a number of controversial points. A discussion of the significance and future direction of such investigations concludes that further clinical trials in selected patient groups are warranted.
Knapp
H R
HR
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-6602.
D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000178:diet therapy* / Q000517:prevention & control; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D015777:Eicosanoids / Q000096:biosynthesis*; D005395:Fish Oils / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans
D004042:Dietary Fats, Unsaturated; D015777:Eicosanoids; D005395:Fish Oils