Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum.
Commercial Allium sativum (garlic) extract was given intravenously to two patients with cryptococcal meningitis and three patients with other types of meningitis. Plasma titers of anti-Cryptococcus neoformans activity rose twofold over preinfusion titers. Anti-C. neoformans activity was detected in four of five cerebrospinal fluid samples but not in pooled normal cerebrospinal fluid.
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
L E
LE
Davis
J K
JK
Shen
Y
Y
Cai
D000935:Antifungal Agents; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000032:analysis / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use; D005737:Garlic; D006801:Humans; D007275:Injections, Intravenous; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal