Insulin allergy: re-evaluation after two decades.
We reevaluated IgE-mediated insulin allergy using sera obtained 16 to 21 years ago and, 1 and 5 years ago. All antibodies had specificity for human and bovine insulin. We reevaluated Prausnitz-Kustner reactivity after 15 years and the IgE antibody and cutaneous reactivity appeared unchanged. IgE-mediated insulin allergy appears to be declining.
Department of Medicine, Northwestern University Medical School, Chicago, Illinois.
R
R
Patterson
M
M
Roberts
L C
LC
Grammer
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D004342:Drug Hypersensitivity / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007328:Insulin / Q000276:immunology*; D007333:Insulin Resistance; D007428:Intradermal Tests; D008407:Mast Cells / Q000276:immunology; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007328:Insulin; D007073:Immunoglobulin E