In vivo enhancement of NK-cell activity by thymopentin.
Natural killer (NK) activities of fresh and IL-2-precultured peripheral blood mononuclear cells (PBMC) were investigated in 13 elderly subjects before and after thymopentin (TP-5) treatment and in 12 age-matched controls. The NK activity of fresh PBMC was found to be significantly higher in subjects given TP-5 at 50 mg s.c. three times per week for one month. Conversely, this type of treatment with TP-5 did not significantly modify the cytotoxic capacity of IL-2-precultured PBMC.
Institute of Internal Medicine, University of Milan, Italy.
C
C
Hu
L
L
Radelli
R
R
Scorza
P
P
Bonara
R
R
Perego
G
G
Fantuzzi
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000502:physiology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D007376:Interleukin-2; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D016305:Thymopentin