Ocular autonomic nerve function in Lambert-Eaton myasthenic syndrome.
Autonomic innervation to the eye and ocular adnexae was assessed in seven patients with Lambert-Eaton Myasthenic Syndrome and 50 age-matched control subjects. Pupil responses to light were abnormal in 69% of LEMS patients, compared with 18% of the control group. Reflex tear production--a screening test for parasympathetic innervation to the lacrimal gland--was below the accepted normal limit in 69% of LEMS patients. Parasympathetic and sympathetic denervation hypersensitivity of the iris musculature were individually present in 57% of LEMS patients, compared with 6% of control subjects. The association between autonomic dysfunction and Lambert-Eaton Myasthenic Syndrome is discussed.
Clark
C V
CV
National Hospital of Nervous Diseases, Queen Square, London.
Newsom-Davis
J
J
Sanders
M D
MD
D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D005123:Eye / Q000294:innervation*; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012025:Reflex, Pupillary