Critical period for induction of congenital hydrocephalus and dysplasia of subcommissural organ by prenatal X-irradiation in rats.
A single whole-body X-irradiation of pregnant Wistar rats at a dose of 1.05 Gy at 10.30, 12.30 and 14.30 h respectively, of gestational day 10 resulted in significantly high incidences of hydrocephalic offspring. No hydrocephalic offspring resulted from X-irradiation of pregnant rats with 1.05 Gy at 16.30 h, whereas a dose of 1.22 Gy at 16.30 h resulted in a low but statistically significant incidence of hydrocephalus. Neither 1.05 Gy nor 1.22 Gy X-irradiation of pregnant rats at 18.30 h resulted in any hydrocephalic offspring. Dysplasia of the subcommissural organ was noticed in all the hydrocephalic brains histologically examined.
Anatomical Laboratory, Gifu College of Medical Technology, Japan.
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Takeuchi
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Takeuchi
D000016:Abnormalities, Radiation-Induced / Q000473:pathology; D000818:Animals; D005260:Female; D005865:Gestational Age; D006849:Hydrocephalus / Q000209:etiology* / Q000473:pathology; D008297:Male; D009490:Neurosecretory Systems / Q000528:radiation effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013351:Subcommissural Organ / Q000002:abnormalities / Q000528:radiation effects*; D014916:Whole-Body Irradiation