The comparative developmental neurotoxicity of lead in humans and animals.
The effects of lead on neurobehavioral development have been extensively investigated in humans as well as animals. This valuable lode of research findings offers a basis for comparing the developmental neurobehavioral toxicity of lead across species and for assessing the validity of animal models of developmental neurotoxicity. Comparisons of human and animal findings suggest that the greatest qualitative similarities involve relatively complex behavioral processes such as cognition and learning. Quantitative comparisons based on dose-response relationships for these endpoints are difficult to make because the relationships are sometimes nonmonotonic (U-shaped) and because blood lead levels may not be directly comparable between species. However, the lowest levels of exposure at which developmental neurobehavioral effects have been observed are similar: 10-15 micrograms/dl in children, less than 15 micrograms/dl in primates, and less than 20 micrograms/dl in rodents. Although the convergence between animal and human findings for other neurobehavioral endpoints is not as striking, sensory-evoked potentials and communicative processes offer two promising areas for continued investigation and cross-species comparison.
Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
J M
JM
Davis
D A
DA
Otto
D E
DE
Weil
L D
LD
Grant
D000818:Animals; D003071:Cognition / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007854:Lead / Q000009:adverse effects / Q000633:toxicity*; D007858:Learning / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000196:embryology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013045:Species Specificity
D007854:Lead