[The effect of fenigidin (nifedipine) and verapamil on renin activity, the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension].
Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that contributed to the enhancement of the hypotensive effect of calcium antagonists. It was established that nifedipine by its effect on the parameters of hemodynamics and the condition of renin-angiotensin system as well as the blood plasma ionized calcium level is superior to verapamil.
Sh N
ShN
Nasyrov
G Ia
GIa
Shvarts
V G
VG
Kukes
I F
IF
Faermark
R D
RD
Siubaev
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D002118:Calcium / Q000097:blood*; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007477:Ions; D009543:Nifedipine / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood*; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D007477:Ions; D000450:Aldosterone; D014700:Verapamil; D012083:Renin; D009543:Nifedipine; D002118:Calcium
Vliianie fenigidina (nifedipina) i verapamila na aktivnost' renina, uroven' ionizirovannogo kal'tsiia i al'dosterona v plazme krovi i pokazateli gemodinamiki u krys so spontannoĭ gipertenzieĭ.