[Unwanted effects of therapeutic drugs on the structure and function of the lung from a clinico-pharmacologic viewpoint].
Undesirable drug effects occur in the lung with about 35 frequently employed drugs and can be life-threatening or life-shortening. As examples, the clinical pattern, course, pathomechanism and therapy are shown for nitrofurantoin, bleomycin, amiodaron, opiates nitrofurantoin, and acetyl salicylic acid. The kinetic aspects of the occurrence and disappearance of the undesirable drug effects are stressed. If the kinetics of amiodaron, for example, are taken into consideration, the occurrence and course of the pulmonary affection can be understood. The use of steroids in case of pulmonary involvement of bleomycin and amiodaron is critically assessed.
Medizinische Hochschule Hannover, Abteilung Klinische Pharmakologie.
J C
JC
Frölich
D004342:Drug Hypersensitivity / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008176:Lung Volume Measurements; D011657:Pulmonary Eosinophilia / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012131:Respiratory Insufficiency / Q000139:chemically induced*
Unerwünschte Wirkungen von Arzneimitteln auf Struktur und Funktion der Lunge aus klinisch-pharmakologischer Sicht.