[The changes of beta-glucuronidase in rabbit model with calcium bilirubinate stone].
The aim of the present study is to determine the beta-glucuronidase changes in bile and hepatobiliary tissue of rabbit model having pigment gallstone by means of biochemical and enzymehistochemical assay methods. The result showed both of the bacterial and non-bacterial beta-glucuronidase take part in the course of pigment gallstone formation. The bacterial beta-glucuronidase level increased quickly before the formation of gallstone, then decreased with control of bacterial infection. Non-bacterial beta-glucuronidase increased slowly in pro-formation stage of gallstone, then kept high level for long period of time. The relationship between beta-glucuronidase and pigment gallstone formation is also discussed.
Li
N
N
Xiao
L
L
Cheng
S
S
Xiao
B
B
Cheng
W
W
Li
Q
Q
D000818:Animals; D001646:Bile / Q000201:enzymology; D001663:Bilirubin / Q000032:analysis; D002118:Calcium / Q000032:analysis; D002769:Cholelithiasis / Q000032:analysis / Q000201:enzymology* / Q000209:etiology; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D011817:Rabbits
D005966:Glucuronidase; D001663:Bilirubin; D002118:Calcium