[Modifications to the surface of T-lymphocytes in chronic candidiasis of the skin and mucous membranes].
27 patients with chronic candidiasis of the skin and mucous membranes have been examined with a view to study the expression of E-receptors and its changes after the incubation of T-lymphocytes with theophylline, levamisole, thymaline and Candida albicans antigen. This study has revealed that, in comparison with healthy persons, most patients show decreased expression of E-receptors, and the character of their changes after incubation with the above-mentioned preparations is essentially different. The deviations revealed in this study have been regarded as the modification of T-cell membranes, which is seemingly one of the reasons of the weak competence of T-cells. In its turn, the expression of E-receptors may be considered as an indicator of the influence of different factors on T-lymphocytes. Substances altering the level of cyclic nucleotides in the cell, the antigenic fractions of the fungal causative agent, the suppression or blocking the action of thymic hormone-like substances may serve as such factors.
N V
NV
Sardyko
T N
TN
Golubeva
G A
GA
Babenko
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000946:Antigens, Fungal / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D002178:Candidiasis, Chronic Mucocutaneous / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D007978:Levamisole / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000187:drug effects / Q000276:immunology*; D012397:Rosette Formation; D013499:Surface Properties; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000946:Antigens, Fungal; D011971:Receptors, Immunologic; D013951:Thymus Hormones; D007978:Levamisole; C032805:thymalin; D013806:Theophylline
Modifikatsii poverkhnosti T-limfotsitov pri khronicheskom kandidoze kozhi i slizistykh obolochek.