Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin.
To evaluate the difluorinated quinolone lomefloxacin in murine typhoid, mice were inoculated intraperitoneally with the LT-2 strain of Salmonella typhimurium and treated with graded doses of the drug given once daily by an orogastric needle. Treatment with lomefloxacin for seven days reduced mortality with a 50% effective dose of 2.5-7.8 mg/kg/day. When given once daily for three days, doses greater than or equal to 5 mg lomefloxacin/kg/day caused significant reductions in splenic counts of S. typhimurium and prevented the inflammatory response to infection in the spleen.
Butler
T
T
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
Cartagenova
M
M
Dunn
D
D
D042462:4-Quinolones; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D006207:Half-Life; D051379:Mice; D015363:Quinolones; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000401:mortality; D012486:Salmonella typhimurium
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin