Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice.
N-Methyl-D-aspartate and bicuculline were administered alone or as a combination by intracerebroventricular injection to mice, and their convulsant activity was monitored. Both of these compounds elicited clonic seizures, though by different mechanisms. However, their simultaneous administration resulted in less than additive induction of clonic activity.
Preclinical Pharmacology Section, NINDS, NIH, Bethesda, MD 20892.
I M
IM
Kapetanovic
C
C
Gennings
C D
CD
Torchin
H J
HJ
Kupferberg
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D016202:N-Methylaspartate; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D001224:Aspartic Acid; D016202:N-Methylaspartate; D001640:Bicuculline