The effect of second generation platinum cytostatics on mammalian cell proliferation.
The effect of three second generation platinum complexes on proliferation of tumor cells (HeLa, C6) and nontumor cells (LEP) was studied, and compared with that of cis-DDP. The highest activity, comparable with cis-DDP, was exhibited by oxoplatinum. CBDCA was somewhat less active in this system, but had a greater effect on both lines of tumor cells than on nontumor cells. Cell proliferation was inhibited least of all by CHIP(IV). The differences observed are discussed from the point of view of the structure and oxidation state of the platinum complexes.
Keprtová
J
J
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Smutná
A
A
Minárová
E
E
Vrána
O
O
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016190:Carboplatin; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV