The basis of antibiotic resistance in bacteria.
The ability of bacteria to resist the inhibitory and lethal actions of antibiotics is a major clinical problem, and has been observed with every antimicrobial agent. In this article, the major mechanisms of antibiotic resistance are reviewed, and the clinical relevance of such resistance in selected bacteria is discussed.
Shafran
S D
SD
Department of Medicine, University of Alberta, Edmonton, Canada.
D001669:Biochemical Phenomena; D001671:Biochemistry; D002463:Cell Membrane Permeability; D003227:Conjugation, Genetic / Q000502:physiology; D004352:Drug Resistance, Microbial / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009154:Mutation; D014161:Transduction, Genetic / Q000502:physiology; D014169:Transformation, Bacterial / Q000235:genetics / Q000502:physiology