Agranulocytosis following infectious mononucleosis.
A girl developed acute agranulocytosis (45/mm3), 37 days after the onset of infectious mononucleosis. The bone marrow showed myeloid hyperplasia with maturation arrest and erythroid hypoplasia. A normal amount of colony forming units of granulocytes and macrophages (CFU-GM) colonies with a relative high number of clusters was observed. Neither anti-neutrophil antibodies nor circulating inhibitors of colony growth were found in serum. Granulocyte and macrophage colony stimulating factor (GM-CSF) activity in the patient's serum rose at this time. The agranulocytosis lasted 5 days and her clinical state soon improved. These results suggested that agranulocytosis was presumably not due to serum factors, including auto-antibodies and/or suppressive substances, and that Epstein-Barr virus (EBV) had some direct or indirect effect on the marrow cells of the myeloid series.
Department of Paediatrics, Sumitomo Hospital, Osaka, Japan.
S
S
Sumimoto
Y
Y
Kasajima
T
T
Hamamoto
T
T
Miyanomae
Y
Y
Iwai
M
M
Mayumi
H
H
Mikawa
D000380:Agranulocytosis / Q000097:blood / Q000209:etiology*; D001853:Bone Marrow / Q000737:chemistry; D002675:Child, Preschool; D003115:Colony-Stimulating Factors / Q000032:analysis; D005260:Female; D006098:Granulocytes / Q000737:chemistry; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008264:Macrophages / Q000737:chemistry
D003115:Colony-Stimulating Factors