Physical development and medical history of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome: a 10- to 12-year follow-up.
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. The children had a general physical examination; parents were interviewed about the medical history of their child with special attention to infectious diseases; growth data were collected; and a developmental neurological examination, an ophthalmological examination, and a lung function test were conducted. In the corticosteroid group significantly more hospital admissions because of infectious diseases during the first years of life were reported. On the other variables no differences between the corticoid and the placebo groups were found.
Department of Obstetrics, Academic Medical Centre, Amsterdam, The Netherlands.
H
H
Smolders-de Haas
J
J
Neuvel
B
B
Schmand
P E
PE
Treffers
J G
JG
Koppe
J
J
Hoeks
D001623:Betamethasone / Q000009:adverse effects*; D002648:Child; D003141:Communicable Diseases / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008487:Medical History Taking; D015999:Multivariate Analysis; D009460:Neurologic Examination; D010808:Physical Examination; D010919:Placebos; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D016032:Randomized Controlled Trials as Topic; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*
D010919:Placebos; D001623:Betamethasone