[Analgesic and anti-inflammatory effects and toxicity of houjianxi].
It is effective for acute and chronic laryngopharyngitis clinically. Houjianxi can raise the pain thresholds during hot-plate test in mice, tail flick test in rats, and writhing test in mice with single dose ig 0.125 to 2.0 g/kg. Houjianxi can also inhibit the swelling of hind paw induced by sc 1% carrageenin 0.1 ml in rats as well as the increased vascular permeability induced by ip 0.7% HAC in mice. Toxic side effects were not observed for Houjianxi ig 48 g/kg x 3 within a day in mice and 1.8 g/kg daily for 90 d in rats.
Li
M
M
Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, Nanning.
Zhou
J
J
Fan
Y
Y
Li
W
W
Qin
L
L
Yang
W
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D011208:Powders; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D011208:Powders