Pharmacokinetics of drug overdose.
Drugs ingested in overdose can have altered pharmacokinetics of absorption, distribution, and elimination. The pathophysiologic consequences of overdose can also change a drug's pharmacokinetic properties. Many toxicologic interventions are based on modifying the drug's pharmacokinetics (e.g., impairing absorption or enhancing elimination). Serum drug monitoring, even with its limitations, does have a role in managing the patient who has taken an overdose.
Department of Pharmacy Services, Hartford Hospital, Connecticut.
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D000042:Absorption; D062787:Drug Overdose / Q000378:metabolism*; D006801:Humans; D010599:Pharmacokinetics; D014018:Tissue Distribution