[In vivo amodiaquine sensitivity of Plasmodium falciparum in the town of Cotonou and in the vicinity (Bénin)].
In the coastal area of Benin, where chloroquine resistant Plasmodium falciparum strains occur, 152 children in the Guezo military camp (Cotonou) and 448 children in a fishermen village (Ekpe), on the southern bank of lake Nokoue, are examined. The falciparum malaria infected children (29 and 135 respectively) have received 35 mg/kg body weight of amodiaquine (Flavoquine) divided in three consecutive daily doses. Only one child among the 69 treated having a parasitemia higher than 1,000/mm3 failed to be cured. The amodiaquine tolerance is excellent for, respectively, 64% and 72% of the children. Minor side-effects are rapidly regressive. The frequency of conjonctival hyperhemia as an amodiaquine side-effect is nevertheless relatively high (14.7%) in the children regularly treated with this drug, e.g. those of the military camp, while it is rare (0.8%) in others, e.g. in the fishermen village children where amodiaquine is unusual as an antimalarial medicine.
Service de Parasitologie, Université de Bordeaux II, France.
C P
CP
Raccurt
H
H
Arouko
F
F
Djossou
F
F
Macaigne
A
A
Massougbodji
T
T
Zohoun
B C
BC
Sadeler
C
C
Ripert
D000293:Adolescent; D000655:Amodiaquine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001541:Benin / Q000453:epidemiology; D002353:Carrier State / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D012424:Rural Population; D014505:Urban Population
D000655:Amodiaquine
Sensibilité in vivo du Plasmodium falciparum à l'amodiaquine dans la ville de Cotonou et ses environs (Bénin).