Transient insomnia associated with a 3-hour phase advance of sleep time and treatment with zolpidem.
A 3-hour phase advance of sleep time was employed to produce a model of transient insomnia. The degree to which this manipulation was effective varied substantially among young, healthy normal sleepers. Zolpidem, an imidazopyridine hypnotic compound, was effective in reversing the sleep disruption in those individuals displaying transient insomnia in this model.
Walsh
J K
JK
Deaconess Hospital Sleep Disorders and Research Center, St. Louis, Missouri 63139.
Schweitzer
P K
PK
Sugerman
J L
JL
Muehlbach
M J
MJ
D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced*; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem