Human recombinant interleukin-2 provokes infiltration of lymphocytes into myocardium and liver in rabbits.
Treatment with human recombinant interleukin-2 (rIL-2) is associated with multiple organ dysfunctions, including hepatic and cardiac toxicities. We present a rabbit model that may be highly suited to investigations of these organ toxicities. Rabbits were treated with rIL-2 at a dose of 3 x 10(6) Cetus units/kg/day in divided doses every 8 h for 9-11 doses. Control animals received either excipient or 5% dextrose in water. Treatment with rIL-2 resulted in hepatic and myocardial infiltration by lymphocytes and mononuclear cells. Monoclonal antibody-staining techniques revealed a high percentage of T lymphocytes. It remains to be shown whether these infiltrates are responsible for the respective organ toxicities or represent merely an epiphenomenon of rIL-2 treatment.
Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington.
M E
ME
Marshall
M L
ML
Cibull
T
T
Pearson
C
C
Hall
S E
SE
Goldblum
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D006331:Heart Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007376:Interleukin-2 / Q000633:toxicity*; D008107:Liver Diseases / Q000473:pathology; D011817:Rabbits; D011994:Recombinant Proteins / Q000633:toxicity; D013601:T-Lymphocytes / Q000187:drug effects*
D007376:Interleukin-2; D011994:Recombinant Proteins