5-Fluorouracil carcinogenesis in BALB/c mice.
5-Fluorouracil, a drug mainly used in the treatment of gastrointestinal tract neoplasms, was administered i.p. to BALB/c mice at the dose of 30 mg/kg body weight once a week for 50 weeks to test its carcinogenicity. The treatment induced a significant increase in lung tumor in both sexes (males, p less than 0.05; females, p less than 0.01) and tumors of the lymphoreticular system in female mice (p less than 0.001). These results suggest that 5-fluorouracil is carcinogenic in mice.
Institute of Pathological Anatomy and Histology, 1st Chair, Perugia University, Italy.
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Cavaliere
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Alberti
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Vitali
D000818:Animals; D015197:Carcinogenicity Tests; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D007274:Injections, Intraperitoneal; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000139:chemically induced; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008224:Lymphoma, Follicular / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012744:Sex Ratio
D005472:Fluorouracil