Endocrine pancreatic secretion in patients after acute pancreatitis.
In 14 nonobese patients after acute pancreatitis and with normal oral glucose tolerance, the response of insulin, C-peptide, and pancreatic glucagon after 100 g of oral glucose was assessed. The curves of insulin and C-peptide were significantly raised compared with those of controls, and no difference was found between the response of patients with a negative (n = 8) and a positive (n = 6) family history of type II diabetes. The curves of pancreatic glucagon did not differ from those found in controls. Our results indicate that a normal response to glucose after recovery from an attack of acute pancreatitis is maintained at the cost of increased insulin secretion.
Stastná
R
R
Research Department of Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Karasová
L
L
Svácek
J
J
Petrásek
R
R
Winkler
L
L
Lánská
V
V
Skála
I
I
Malý
J
J
D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism*; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005934:Glucagon