Clonal immunoglobulin gene rearrangement in nodular lymphoid hyperplasia of the gastrointestinal tract associated with common variable immunodeficiency.
The authors report a case of common variable immunodeficiency associated with nodular lymphoid hyperplasia of the gastrointestinal tract in which a clonal population of lymphoid cells was detected by immunophenotypic and genotypic studies on tissue obtained by colonoscopic biopsy. The patient has been followed up for more than 50 months without clinical, radiographic, or pathologic evidence of lymphoma. The significance of clonal rearrangement in the setting of immunodeficiency and the role of genotypic studies in defining lymphoid malignancy are discussed.
Laszewski
M J
MJ
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Kemp
J D
JD
Goeken
J A
JA
Mitros
F A
FA
Platz
C E
CE
Dick
F R
FR
D000293:Adolescent; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D015139:Blotting, Southern; D015342:DNA Probes; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D006965:Hyperplasia / Q000235:genetics / Q000276:immunology / Q000473:pathology; D007124:Immunoenzyme Techniques; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D010641:Phenotype
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015342:DNA Probes