Mechanisms involved in the stimulation of aldosterone production by angiotensin II, vasopressin and endothelin.
1. Endothelin (ET), vasopressin (VP) and angiotensin II (AII) all stimulate aldosterone production in adrenal glomerulosa cells but the response to AII is greater than that to either ET or VP. 2. Total inositol phosphate responses to AII and ET were similar but the response to VP was lower. 3. Cytosolic free Ca2+ responses to AII were higher than to either of the other peptides. 4. Metabolism of 145IP3 was different under stimulation by the three different peptides. 5. Adrenal glomerulosa cells can distinguish between three different agonists which stimulate phosphatidylinositol turnover and produce a selective response to each peptide.
Woodcock
E A
EA
Baker Medical Research Institute, Prahran, Victoria, Australia.
Tanner
J K
JK
Caroccia
L M
LM
Little
P J
PJ
D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D016232:Endothelins; D004730:Endothelium, Vascular; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*; D015384:Zona Glomerulosa / Q000378:metabolism
D016232:Endothelins; D007295:Inositol Phosphates; D010455:Peptides; D014667:Vasopressins; D000804:Angiotensin II; D000450:Aldosterone; D002118:Calcium