[Disulfiram implants. Lack of pharmacological and clinical effects].
The therapeutic rationale for using implanted disulfiram is possible inhibition of the liver enzyme acetaldehyde dehydrogenase, producing an acetaldehyde-mediated aversive reaction after intake of ethanol. Several studies using volunteers and patients in a double blind controlled study produced no evidence that a disulfiram implant (1 g) has any significant pharmacological or clinical action, except for a higher frequency of local surgical complications.
Johnsen
J
J
Incognito Klinikk, Statens rettstoksikologiske institutt, Oslo.
Mørland
J
J
D000437:Alcoholism / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004221:Disulfiram / Q000008:administration & dosage* / Q000627:therapeutic use; D004343:Drug Implants / Q000009:adverse effects; D006801:Humans; D014946:Wound Infection / Q000209:etiology
D004343:Drug Implants; D004221:Disulfiram
Disulfiramimplantasjon. Manglende farmakologisk og klinisk effekt.