Studies on steroid binding proteins in normal tissues and tumor cell lines.
Steroid binding proteins bind steroid hormones with high affinity and their function is to carry those hormones in the extracellular compartment. Since their discovery more than fifty years ago, many reports concerning their physicochemical structures and functions have contributed to the better understanding of those proteins. Recent advances in recombinant DNA technology have led to the availability of molecular probes for these proteins, and new approaches have been used to analyse their gene structures as well as the regulation of their synthesis. In the present report, we will review the new findings of the last five years which include the cloning and sequencing of the cDNAs and genes for corticosteroid binding globulin, testosterone estradiol binding globulin and androgen binding protein, as well as the tissue distribution and regulation of their mRNAs in normal tissues and cancer cell lines.
Population Council Rockefeller University, New York, NY 10021.
J
J
Reventós
G L
GL
Hammond
N A
NA
Musto
C W
CW
Bardin
D000727:Androgen-Binding Protein / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism / Q000473:pathology; D012689:Sequence Homology, Nucleic Acid; D012738:Sex Hormone-Binding Globulin / Q000235:genetics / Q000378:metabolism*; D014156:Transcortin / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D000727:Androgen-Binding Protein; D006728:Hormones; D012738:Sex Hormone-Binding Globulin; D004247:DNA; D014156:Transcortin