Antifungal drugs affect adherence of Candida albicans to acrylic surfaces by changing the zeta-potential of fungal cells.
The effect of sub-inhibitory concentrations of antifungal drugs on the adherence of Candida albicans to acrylic surfaces was investigated. Among five antifungals tested, azalomycin F and aculeacin A significantly enhanced the adherence. The zeta-potential of fungal cells was affected by antifungal drugs, whereas no significant change in cell surface hydrophobicity was observed. The relationship obtained between the change in the adherence and that in zeta-potential suggests that the enhanced adherence was caused by decreased electric repulsive forces.
Department of Microbiology, Hiroshima University School of Dentistry, Japan.
Y
Y
Miyake
T
T
Tsunoda
S
S
Minagi
Y
Y
Akagawa
H
H
Tsuru
H
H
Suginaka
D000179:Acrylates; D000268:Adhesiveness; D000666:Amphotericin B / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D004586:Electrophoresis; D007654:Ketoconazole / Q000494:pharmacology; D018942:Macrolides; D008825:Miconazole / Q000494:pharmacology; D010456:Peptides, Cyclic
D000179:Acrylates; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; D010456:Peptides, Cyclic; C000232:azalomycin-F; C011634:aculeacin A; D008825:Miconazole; D000666:Amphotericin B; D007654:Ketoconazole