Autoradiographic localization of mas proto-oncogene mRNA in adult rat brain using in situ hybridization.
The cellular localization and the distribution of the mas proto-oncogene/angiotensin receptor mRNA have been studied in the male rat brain using in situ hybridization with radiolabelled mas cRNA probes. Neuronal cell populations in the forebrain were selectively labelled. A strong specific labelling was demonstrated in the dentate gyrus, the CA3 and CA4 areas of the hippocampus, the olfactory tubercle (medical part), the piriform cortex and the olfactory bulb, while a weak to moderate labelling was present all over the neocortex and especially in the frontal lobe.
Bunnemann
B
B
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Fuxe
K
K
Metzger
R
R
Mullins
J
J
Jackson
T R
TR
Hanley
M R
MR
Ganten
D
D
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology / Q000201:enzymology*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009928:Organ Specificity; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D043562:Receptors, G-Protein-Coupled; D013462:Sulfur Radioisotopes; D014544:Uridine Triphosphate / Q000378:metabolism
D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D043562:Receptors, G-Protein-Coupled; D013462:Sulfur Radioisotopes; D011505:Protein-Tyrosine Kinases; D014544:Uridine Triphosphate