[New possibilities in searching for immunomodulators among compounds with a steroid structure].
It was shown that a phytosteroid ecdisterone which is the principle of a new tonic drug ecdisten in doses of 5-20 mg/kg is able to stimulate the primary immune reaction slightly effecting the indices of T-cell immunity activity and phagocyte functions. On increasing ecdisterone dose to 50 mg/kg inhibition of the number of antibody cells in the mouse spleen was marked.
Kuz'mitskiĭ
B B
BB
Golubeva
M B
MB
Konoplia
N A
NA
Kovganko
N V
NV
Akhrem
A A
AA
D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004441:Ecdysterone / Q000494:pharmacology*; D004926:Escherichia coli; D006087:Graft vs Host Reaction / Q000187:drug effects / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D004441:Ecdysterone
Novye vozmozhnosti izyskaniia immunomoduliatorov sredi soedineniĭ steroidnoĭ struktury.