[The effect of insulin and thyroxine on the age-related dynamics of synthesis and degradation of proteins in skeletal muscles of cattle].
The intensity of sarcoplasmic and myofibrillar protein synthesis in skeletal muscle homogenates of the cattle aged from 45 to 360 days is 3.5 and 3.8 times reduced, respectively, and remains at the same level in the old beef cattle aged 540 days. Exogenous insulin and thyroxin increases the sarcoplasmic and myofibrillar protein synthesis in skeletal muscle homogenates of animal at certain stages of postnatal ontogenesis. The catepsin and neutral protease activities are 2.0 and 1.7 times as low in the skeletal muscle of the cattle aged from 45 to 360 days while in the subsequent period they change slightly. Exogenous insulin decreases the catepsin protease activities but does not change the neutral protease activities in the skeletal muscle of animal at the most stages of postnatal ontogenesis. Exogenous thyroxin increases the catepsin and neutral protease activities in skeletal muscle of animals at the some stages of postnatal ontogenesis.
Vovk
S I
SI
Ianovich
V G
VG
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D007328:Insulin / Q000494:pharmacology*; D009124:Muscle Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*
D007328:Insulin; D009124:Muscle Proteins; D013974:Thyroxine
Vplyv insulinu ĭ tyroksynu na vikovu dynamiky syntezu i rozshcheplennia bilkiv u skeletnykh m'iasakh velykoi rogatoï khudoby.