Effect of enalapril on mortality in congestive heart failure. Follow-up survival data from the CONSENSUS trial.
The CONSENSUS trial, which compared the effects of enalapril and placebo on survival in severe heart failure, had a limited blinded treatment period. Follow-up for 8.5 months from the end of blinded therapy was performed. Enalapril therapy was encouraged in all patients during follow-up. Of the 135 surviving patients, 58 had previously been allocated placebo and 77 had been allocated enalapril. The follow-up mortality rates in those receiving enalapril were 18 (31%) and 16 (21%), respectively. Mortality was markedly lower in patients treated with enalapril than in those not started on the drug (16% vs 61%). The follow-up data strongly support the original CONSENSUS data regarding reduction of mortality in severe heart failure after the addition of enalapril.
Swedberg
K
K
Department of Medicine, Gothenburg University, Ostra Hospital, Sweden.
Kjekshus
J
J
D004656:Enalapril / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006333:Heart Failure / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012537:Scandinavian and Nordic Countries; D016019:Survival Analysis
D004656:Enalapril