Metabolic response to egg white and cottage cheese protein in normal subjects.
In type II diabetic subjects, we previously demonstrated differences in the serum insulin, C-peptide, and glucagon response to ingestion of seven different protein sources when administered with 50 g of glucose. The response was smallest with egg white and greatest with cottage cheese protein. In the present study, we compared the responses to 50 g of the above two proteins ingested without glucose in normal male subjects. We also determined the proportion of each ingested protein converted to urea nitrogen. The incremental area response integrated over 8 hours for serum insulin, C-peptide, glucagon, alpha-amino-nitrogen (AAN), and urea nitrogen were all approximately 50% less following egg white. This was associated with a 50% smaller conversion of protein to urea. Overall, 70% of the cottage cheese but only 47% of the egg white protein could be accounted for by urea formation. Most likely the smaller hormonal response to egg white is due to poor digestibility of this protein.
Metabolic Research Laboratory, VA Medical Center, Minneapolis, MN 55417.
F Q
FQ
Nuttall
M C
MC
Gannon
D000328:Adult; D000607:Aminoacetonitrile / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002096:C-Peptide / Q000097:blood; D003611:Dairy Products; D004044:Dietary Proteins / Q000494:pharmacology*; D004527:Egg Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D013217:Starvation / Q000097:blood; D014508:Urea / Q000652:urine
D001786:Blood Glucose; D002096:C-Peptide; D004044:Dietary Proteins; D004527:Egg Proteins; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D000607:Aminoacetonitrile; D014508:Urea; D005934:Glucagon