A randomized comparison of midazolam and diazepam injectable emulsion in cataract surgery.
The purpose of this study was to compare the psychomotor recovery of patients sedated with either midazolam or Diazemuls using the digit symbol substitution test and the Trieger test. Sixty patients were allocated in random double-blind fashion to receive either midazolam or diazepam in oil emulsion (Diazemuls) as intravenous sedation for cataract surgery. Both groups received fentanyl 0.5 micrograms.kg-1 IV. Tests of cognition were performed by the patients prior to sedation and at half-hourly intervals for three hours after cataract surgery. In a dose ratio of 1:4, midazolam was found to produce better sedation but more prolonged recovery than Diazemuls. Anterograde amnesia was comparable in the two groups, while more patients in the Diazemuls group developed episodes of apnoea and venous irritation.
Department of Anaesthesia, University of Toronto, Ontario, Canada.
F
F
Chung
D C
DC
Cheng
C
C
Seyone
B J
BJ
Dyck
D000368:Aged; D002387:Cataract Extraction; D003975:Diazepam / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004655:Emulsions; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007432:Intraoperative Period; D008297:Male; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic
D004655:Emulsions; D003975:Diazepam; D008874:Midazolam