The effect of amylin and calcitonin gene-related peptide on insulin-stimulated glucose transport in the diaphragm.
The two peptides calcitonin gene related peptide (CGRP) and amylin at 1 uM levels in an isolated rat diaphragm preparation inhibited insulin stimulated 2-deoxy[3H]glucose transport by 30 and 60 percent, respectively; this was the case at maximal (1 uM) and sub-maximal (0.5 mU) insulin concentrations. No effect was measured on the basal level of 2-deoxy[3H]glucose transport.
Department of Biochemistry, University College, London, UK.
J S
JS
Hothersall
R P
RP
Muirhead
S
S
Wimalawansa
D000682:Amyloid / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003964:Diaphragm; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D058228:Islet Amyloid Polypeptide; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000682:Amyloid; D003837:Deoxy Sugars; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D003847:Deoxyglucose; D015740:Calcitonin Gene-Related Peptide