Conformationally restricted peptides through short-range cyclizations.
The various types of conformationally restricted peptides obtained by short-range cyclizations, from residue i to residue i + 1, are presented. Relevant examples of N in equilibrium C alpha, C' in equilibrium C alpha, N in equilibrium C', C alpha in equilibrium C alpha, C' in equilibrium C', and N in equilibrium N cyclizations are reported and the pertinent literature listed. In the discussion emphasis is place on the conformational consequences for peptides from the incorporation of such ring structures.
C.N.R., Department of Organic Chemistry, University of Padova, Italy.
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Toniolo
D003500:Cyclization; D010456:Peptides, Cyclic / Q000032:analysis / Q000138:chemical synthesis*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D010456:Peptides, Cyclic