Growth hormone response to intravenous diazepam and placebo in 82 healthy men.
Growth hormone (GH) response to placebo and two different doses of diazepam (0.12 mg/kg and 0.20 mg/kg) were evaluated in 82 healthy young men. Both diazepam doses had a significant effect on the growth hormone secretion, with peak values occurring between 30 and 60 min postinfusion, after which levels returned to baseline. There was also a small but significant change in this hormone over time after placebo, but this was reflected by a slow rise following the saline infusion. Individual GH responses to diazepam were variable and, when a cut-off point of 7.5 ng/ml GH increase before 90 min postdrug administration was used, 1% of the men demonstrated a response after placebo, 17% after low-dose diazepam, and 37% following high-dose diazepam. The clinical implications and limitations of these findings are discussed.
Escola Paulista de Medicina, Sao Paulo, Brasil.
M G
MG
Monteiro
M A
MA
Schuckit
R
R
Hauger
M
M
Irwin
L A
LA
Duthie
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016032:Randomized Controlled Trials as Topic
D013006:Growth Hormone; D003975:Diazepam