Down-regulation of angiotensin II receptors in subfornical organ of young male rats by chronic dietary sodium depletion.
The effect of a 4-week period of selective dietary sodium depletion on the regulation of peripheral and central angiotensin II receptors was studied in young rats, by quantitative autoradiography. Moderate sodium depletion (0.05% sodium in diet) significantly impaired growth rate and stimulated the renin-angiotensin system, but did not result in significant changes in peripheral or central angiotensin II receptors. In young rats, the impairment of the growth rate and the stimulation of the peripheral renin-angiotensin system were more notable after profound sodium depletion (0.005% sodium in diet). Such sodium depletion corresponded to a down-regulation of kidney angiotensin II receptors, and to an up-regulation of adrenal zona glomerulosa angiotensin II receptors. These effects are similar to those reported in adult rats. In the brain, profound sodium depletion down-regulated angiotensin II receptors in the subfornical organ. There were no changes in angiotensin II receptors in another brain structure, the paraventricular nucleus. Our results indicate a participation of selective central angiotensin II receptors in the regulation of sodium metabolism and suggest that factors other than circulating angiotensin II levels might contribute to regulate the number of angiotensin II receptors in the subfornical organ.
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
P E
PE
Ray
E J
EJ
Ruley
J M
JM
Saavedra
D000311:Adrenal Glands / Q000378:metabolism; D000450:Aldosterone / Q000652:urine; D000818:Animals; D007668:Kidney / Q000378:metabolism; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000378:metabolism*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000172:deficiency* / Q000378:metabolism; D013356:Subfornical Organ / Q000378:metabolism* / Q000502:physiology
D011945:Receptors, Angiotensin; D000450:Aldosterone; D012964:Sodium; D012083:Renin