Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model.
The tissue around loose total joint replacement prostheses displays a synovial-like lining comprised of cells that produce IL-1 and PGE2, mediators of inflammation that stimulate bone resorption. Particles of titanium alloy, as well as cobalt-chromium alloy and polyethylene, were found to aggravate the histiocytic response and production of IL-1 and PGE2. Tissue with similar histological and biochemical features was produced in a canine model of the aseptic loose cemented femoral stem.
Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
T S
TS
Thornhill
R M
RM
Ozuna
S
S
Shortkroff
K
K
Keller
C B
CB
Sledge
M
M
Spector
D000818:Animals; D001843:Bone Cements; D002857:Chromium; D003035:Cobalt; D015232:Dinoprostone / Q000378:metabolism; D004285:Dogs; D005549:Foreign-Body Reaction / Q000378:metabolism / Q000473:pathology*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D011095:Polyethylenes; D011475:Prosthesis Failure; D012307:Risk Factors; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology*; D014025:Titanium
D001843:Bone Cements; D007375:Interleukin-1; D011095:Polyethylenes; D002857:Chromium; D003035:Cobalt; D014025:Titanium; D015232:Dinoprostone