[Testosterone in saliva: application to the follow-up of prostate cancer].
The basic aspects of steroid hormones transport, their tissular release and the interpretation of salivary testosterone values as a reflect of the free hormone in serum are reviewed in this article, as well as the salivary testosterone applications in several disorders, with a special emphasis on prostatic carcinoma. The usefulness of salivary testosterone in the short-term (n = 4) and long-term (n = 13) follow-up of patients affected by prostatic carcinoma after medical or surgical orchiectomy has also been studied. Our results show a correlation (r = 0.62) between salivary and serum concentration values, as well as a significative decrease (p less than 0.001) in both quantities after treatment. Both these findings and the advantages inherent to the sampling obtaining, lead to the conclusion that salivary testosterone is a good alternative to serum testosterone.
Sección de Hormonas, Hospital de Bellvirge, Principes de España, Barcelona, España.
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Navarro-Moreno
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Rivera-Coll
D000726:Androgen Antagonists / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D012463:Saliva / Q000032:analysis*; D013739:Testosterone / Q000032:analysis* / Q000097:blood
D000726:Androgen Antagonists; D014408:Biomarkers, Tumor; D013739:Testosterone
Testosterona en saliva: aplicación al seguimiento en el cáncer de próstata.