[Current status of knowledge of the effect of benzene. Impairment of blood and hemopoiesis].
The alteration of the hemopoiesis is the result of a lot of particular cases. The inhibition of the microtubuli assembly suppresses the cell division because of the missing of the spindle formation. This is associated with an inhibition of the supporting stroma of the bone marrow and of the different lymphocytes complicated with a depression of colony stimulating factors. There is also an alkylation of the nuclear and mitochondrial RNA, DNA and proteins together with an inactivation of the DNA polymerase. Immunosuppressive effects are associated with autoimmune events. Benzene is classified as a weak carcinogenic initiator.
Bittersohl
G
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Betriebsgesundheitswesen der Klein- und Mittelbetriebe Merseburg.
D000741:Anemia, Aplastic / Q000139:chemically induced; D001554:Benzene / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007938:Leukemia / Q000139:chemically induced
D001554:Benzene
Der gegenwärtige Stand der Kenntnisse über die Benzenwirkung. Schädigung des Blutes und der Blutbildungsstäten.