[Pulmonary blastoma. Immunohistochemical characterization of heteromorphic tumor components].
The reaction pattern found in thirteen different pulmonary blastomas was tested with four different polyclonal and six different monoclonal antibodies using the avidin-biotin-reaction. Immunohistochemically, the tumours showed positive reactions, both with antibodies that are considered to be epithelial markers (K11, EMA), and with antibodies that indicate a differening mesenchymal differentiation (vimentine, desmine, protein-S100). It was not possible to label any tumour cells with the antibodies anti-beta-HCG, anti-NSE, anti-lysozyme or anti-CEA. The negative response of the CEA reaction can be useful for the differentiation from pulmonary adenocarcinoma, in particular in the case of tumours with highly differentiated glandular components.
Brockmann
M
M
Institut für Pathologie der Berufsgenossenschaftlichen Krankenanstalten Bergmannsheil Bochum, Universitätsklinik Bochum.
Hecker
A
A
Müller
K M
KM
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor
Das pulmonale Blastom. Immunhistochemische Charakterisierung heteromorpher Tumorkomponenten.