[Comparative evaluation of the effects of isoptin and obsidan on central and cerebral hemodynamics in patients with hypertension during physical exercise].
Isoptin and obsidan were demonstrated to cause a significant increase in exercise tolerance in patients with Stages I and II hypertensive disease. The response of blood pressure to isoptin and obsidan was virtually identical, yet isoptin acted longer. When obsidan was administered, there was a decrease in specific peripheral vascular resistance with a stepwise elevation of blood pressure, whereas isoptin promoted its slight rise with maximally elevated blood pressure. Isoptin administration prevented brain hyperperfusion at maximum blood pressures.
Adibaev
O A
OA
Aleĭnikov
V K
VK
Veber
V R
VR
Kazymov
M S
MS
D000328:Adult; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D002986:Clinical Trials as Topic; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
D011433:Propranolol; D014700:Verapamil
Sravnitel'naia otsenka vliianiia izoptina i obzidana na tsentral'nuiu i mozgovuiu gemodinamiku u bol'nykh gipertonicheskoĭ bolezn'iu pri fizicheskoĭ nagruzke.