Captopril provides sustained hemodynamic benefits in dogs with experimentally induced mitral regurgitation.
Mitral regurgitation was created surgically in 10 dogs. After measurement of baseline hemodynamic parameters on day 2, treatment with captopril (2 mg/kg orally 3 times daily) was begun in five dogs. Five control dogs received no therapy during the study. The hemodynamic parameters were measured again at weeks 6 and 22. In the treated dogs, the forward ejection fraction (FEF) increased slightly and the total peripheral resistance index (TPRI) decreased. In the controls, the FEF decreased and the TPRI increased. Changes in FEF and TPRI were significantly different between the two groups. The change in FEF correlated significantly with the change in TPRI in both groups. Although the most dramatic changes were observed at week 6, the differences persisted throughout the study. Captopril administration resulted in sustained hemodynamic improvement and may, therefore, delay the onset of congestive heart failure in dogs with mitral regurgitation.
Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
L W
LW
Blackford
A L
AL
Golden
J M
JM
Bright
R M
RM
Bright
R E
RE
Gompf
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006333:Heart Failure / Q000517:prevention & control / Q000662:veterinary*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002216:Captopril