[Effect of yiqi-yangyin prescription on bile composition of cholelithiasis patients].
There were 41 postoperative patients of cholelithiasis with manifestation of Qi-Yin deficiency, had treated with Yiqi Yangyin Prescription. The regimens was 2 weeks as a course, thereafter bile specimens were taken through T tube drainage, and biochemical analysis were performed in order to determine the composition in consequence of the comparison of the treated patients with the control groups. There were 19 patients of bile pigment stone in whom 10 treated with the prescription and 9 were served as control. The results showed that the total bilirubin, unconjugated bilirubin, the concentration of calcium ion and the activity of beta-glucuronidase were markedly decreased as compared to those in the control group (P less than 0.05), the concentration of bile acid markedly increased than that in the control group (P less than 0.05). There were 22 patients of cholesterol stone, 11 treated with the prescription and 11 were served as control group. The results were the same as in bile pigment stone group except decreased in conjugated bilirubin (P less than 0.05), and the unconjugated bilirubin were remained unchanged (P greater than 0.05) as compared to the control group. The ratio of unconjugated bilirubin to total bilirubin and the ratio of bile acid to bilirubin were markedly decreased as compared to those in the control group. The above observation showed promptly that Yiqi-Yangyin Prescription gave a promise influence on lithogenic bile of cholelithiasitic patients, and also investigated the mechanism of the prescription used for deficiency patients with biliary troubles.
Dept. of Surgery, Affiliated Hospital of Hubei College of TCM, Wuhan.
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D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002769:Cholelithiasis / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; D005966:Glucuronidase; D001663:Bilirubin; D002118:Calcium