Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial.
Seventeen patients with long-lasting idiopathic trigeminal neuralgia (ITN) were treated with either five, weekly peripheral streptomycin/lidocaine (S/L) or lidocaine alone injections, in a double blind controlled study. Eight patients responded initially to the treatment in the S/L group and three patients in the lidocaine group. Pain recurred in four patients from the S/L group within two weeks and six months following the last injection. One patient from the lidocaine group remained pain-free for eight months. At the final assessment, three patients from the S/L group and two patients from the lidocaine group remained pain-free up to 30 months. Neither treatment affected sensory functions of the injected nerves. It is concluded that S/L injections are initially effective in the treatment of ITN. In the long term, however, their effects are similar to the effects of lidocaine alone.
Stajcić
Z
Z
Oral Surgery Clinic, Faculty of Stomatology, University of Beograd, Yugoslavia.
Juniper
R P
RP
Todorović
L
L
D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008340:Mandibular Nerve; D008442:Maxillary Nerve; D008875:Middle Aged; D009407:Nerve Block; D010919:Placebos; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014276:Trigeminal Nerve; D014277:Trigeminal Neuralgia / Q000188:drug therapy*
D004338:Drug Combinations; D010919:Placebos; D008012:Lidocaine; D013307:Streptomycin