Intestinal hemodynamics during laparotomy: effects of thoracic epidural anesthesia and dopamine in humans.
The effects of thoracic epidural anesthesia (TEA) and dopamine infusion (4 micrograms.kg-1.min-1) on superior mesenteric artery blood flow (SMABF), the mesenteric arteriovenous oxygen difference (AVDO2), and the mesenteric venous lactate concentration were studied in nine patients before abdominal aortic reconstruction. Thoracic epidural anesthesia reduced SMABF, as measured by electromagnetic flowmetry, to 77% +/- 8% (mean +/- SEM) of control (P less than 0.05), and mean arterial pressure to 46% +/- 4% of control (P less than 0.01). The mesenteric AVDO2 increased from 27 +/- 3 to 39 +/- 6 mL/L (P less than 0.05) and superior mesenteric venous lactate from 1.03 +/- 0.11 to 1.60 +/- 0.38 mmol/kg (P less than 0.05); systemic AVDO2 and lactate did not change. Dopamine had no significant effect on SMABF and mean arterial pressure before TEA. However, dopamine increased SMABF during TEA (from 77% +/- 8% to 137% +/- 21% of control; P less than 0.01), returned mesenteric AVDO2 to 27 +/- 3 mL/L (P less than 0.05), and elevated mean arterial pressure to 62% +/- 4% of control (P less than 0.05). It is concluded that the decrease in perfusion pressure during TEA reduces SMABF with resultant evidence of intestinal reductive metabolism. The intestinal blood flow during TEA was improved by dopamine.
Department of Anesthesiology, University Hospital, Lund, Sweden.
J
J
Lundberg
D
D
Lundberg
L
L
Norgren
E
E
Ribbe
J
J
Thörne
O
O
Werner
D000368:Aged; D000767:Anesthesia, Epidural; D001012:Aorta, Abdominal / Q000601:surgery; D001786:Blood Glucose; D004298:Dopamine / Q000097:blood / Q000494:pharmacology*; D004737:Enflurane; D004837:Epinephrine / Q000097:blood; D005260:Female; D005283:Fentanyl; D008401:Gas Chromatography-Mass Spectrometry; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011773:Pyruvates / Q000097:blood; D012083:Renin / Q000097:blood; D013152:Splanchnic Circulation / Q000187:drug effects*
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D004737:Enflurane; D012083:Renin; D005283:Fentanyl; D004298:Dopamine; D004837:Epinephrine