Initiation of translation at a UAG stop codon in the aldolase gene of Plasmodium falciparum.
The gene coding for the key glycolytic enzyme fructose-1,6-diphosphate aldolase of the human malaria parasite Plasmodium falciparum lacks a functional AUG initiation codon for translation. Protein sequences of natural or in vitro translated aldolase include the candidate start methionine residue at internal positions. No additional AUG start codon is found in genomic DNA, cDNA or mRNA sequences. Instead, a UAG chain termination codon is recognized as the start signal of protein synthesis in vivo and in vitro.
Geneva Blood Centre, University Cantonal Hospital, Geneva, Switzerland.
P
P
Ghersa
I K
IK
Shrivastava
L H
LH
Perrin
H
H
Döbeli
D J
DJ
Becherer
H
H
Matile
B
B
Meier
U
U
Certa
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010963:Plasmodium falciparum / Q000201:enzymology / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012156:Reticulocytes / Q000378:metabolism; D013728:Terminator Regions, Genetic / Q000235:genetics
D003062:Codon; D012333:RNA, Messenger; D005634:Fructose-Bisphosphate Aldolase