Epidural droperidol and morphine for postoperative pain.
Epidural morphine is effective in the treatment of postoperative pain, but the incidence of associated side effects is high. To assess a potential reduction of opioid side effects by droperidol, 4 mg morphine with either placebo or 2.5 mg droperidol was injected epidurally in a double-blind, randomized, postoperative trial. Forty patients undergoing hip replacement surgery were studied. The overall incidence of side effects during the first 24 h in the group receiving droperidol and morphine was less than 50% of that in the group receiving placebo and morphine (P less than 0.008). Pruritus, emesis, nausea, urinary retention, and hypotension were diminished in the group with droperidol. No significant differences in duration or quality of analgesia were seen. Epidural injection of droperidol did not result in any local or systemic side effects.
Department of Anesthesiology, Klinik am Rosenberg, Heiden, Switzerland.
P
P
Naji
M
M
Farschtschian
O H
OH
Wilder-Smith
C H
CH
Wilder-Smith
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004329:Droperidol / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
D004338:Drug Combinations; D009020:Morphine; D004329:Droperidol