Current issues in the development of a vaccine against HIV infection.
There are a variety of complex issues involved in current efforts to design and test a safe and effective vaccine against HIV-1 infection. Although a number of important insights already have been gained, future advances in vaccine development must overcome a number of obstacles. These include the lack of a suitable animal model for HIV-1 infection and our incomplete understanding of the protective immune response in this disease as well as uncertainties about the most appropriate strategy for large-scale testing of promising candidate vaccines.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
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Davey
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D014611:Vaccination
D000276:Adjuvants, Immunologic; D000888:Antibodies, Anti-Idiotypic