[Hypoinsulinemia, hyperglycemia and circulating antibodies to the islet cells during the development of streptozotocin diabetes in rats].
The time course of metabolic parameters and islet cell surface antibodies (ICSA) in low-dose streptozotocin (STZ)-induced diabetes in rats was studied, a total STZ dose being 160 mg/kg body weight. Two-phase diabetes development was observed. Initial mild hypoinsulinemia and hyperglycemia turned to more severe diabetes after day 24 which was preceded by the first ICSA peak at day 13. The second ICSA peak occurred at day 35. The data obtained suggest that in this model of diabetes the toxic STZ effect induces both the diabetic syndrome and humoral autoimmunity to beta-cells, and the latter leads to further impairment of diabetes.
Pankov
Iu A
IuA
Kondrat'ev
Ia Iu
IaIu
Gorskova
V A
VA
Keda
Iu M
IuM
Osipova
T A
TA
Arbuzova
M I
MI
Sadovnikova
N V
NV
Fedotov
V P
VP
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology / Q000276:immunology; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology* / Q000276:immunology; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007328:Insulin / Q000097:blood / Q000172:deficiency*; D007330:Insulin Antibodies / Q000032:analysis; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001323:Autoantibodies; D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies
Gipoinsulinemiia, giperglikemiia i tsirkuliruiushchie antitela k ostrovkovym kletkam pri razvitii streptozototsinovogo diabeta u krys.