[Morphaea profunda].
A 47-year-old woman with a solitary morphoea profunda on the flexor aspect of the left thigh is described. Clinically the lesion is characterized by a circumscribed, deeply indurated sclerotic plaque. The main histopathological features were sclerotic collagen changes and a striking accumulation of inflammatory cells in the deep dermis as well as in the subcutaneous tissue. Plasma cells and T- and B-lymphocytes were the predominant cellular components of the infiltrate. The patient had an elevated serum titre of antibodies to Borrelia burgdorferi. The patient was treated with penicillin, which brought about a remarkable improvement. These findings provide further support for the concept that in some cases morphoea profunda may be a manifestation of Borrelia infection.
Dermatologische Universitätsklinik Basel.
S A
SA
Büchner
T
T
Rufli
D000907:Antibodies, Bacterial / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D015748:Borrelia burgdorferi Group / Q000276:immunology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D008193:Lyme Disease / Q000473:pathology*; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
Morphaea profunda.