[Comparison of antianginal effects of diltiazem and metoprolol in patients with ischemic heart disease with different clinical forms of angina pectoris].
Diltiazem, a new calcium antagonist, and metoprolol, a cardioselective beta-adrenoblocker, were comparatively studied in 53 patients with exertional angina and 11 patients with spontaneous angina. A simple blind random method using placebo, graded physical exercise test employing a bicycle ergometer, and Holter monitoring were applied to evaluate the efficiency of the antianginal treatment. A good antianginal effect was exhibited by the both drugs in exercise-induced angina. Diltiazem was found to be effective in 74% of the patients with exertional angina, whereas metoprolol was beneficial in 62%. Unlike diltiazem (85.7%), metoprolol (50.0%) was less potent in spontaneous angina.
A B
AB
Guliev
B A
BA
Sidorenko
V P
VP
Lupanov
I V
IV
Krutovskikh
F M
FM
Iaroshevskaia
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000145:classification / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy*; D004110:Diltiazem / Q000627:therapeutic use*; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D004110:Diltiazem; D008790:Metoprolol
Sravnenie antianginal'nogo deĭstviia dil'tiazema i metoprolola u bol'nykh ishemicheskoĭ bolezn'iu serdtsa s razlichnymi klinicheskimi formami stenokardii.