Megakaryocyte endomitosis: a review.
During the early stages of their differentiation, megakaryocytes become polyploid through repeated DNA replication and endomitotic cycles without cytokinesis. The molecular basis for the process of polyploidization remains unknown. This review summarizes available information on the cell biology of the process of endomitosis.
Jackson
C W
CW
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
D000818:Animals; D002875:Chromosomes / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology*; D011123:Polyploidy