Cefepime concentrations in bronchial mucosa and serum following a single 2 gram intravenous dose.
The concentrations of cefepime in bronchial mucosa were measured after intravenous administration of a single 2 g dose in 20 patients undergoing diagnostic fibreoptic bronchoscopy. These concentrations were compared with simultaneous serum concentrations. The mean bronchial mucosal concentration was 24.1 mg/kg (s.d. 17.8 mg/kg) and the mean serum concentration was 40.4 mg/l (s.d. 28.1 mg/l). The mean percentage penetration was 59.8% (s.d. 12.5%). We conclude that a twice daily dosing of cefepime would be adequate for most respiratory infections although an 8-hourly dose may be necessary in pseudomonal infections.
Chadha
D
D
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, UK.
Wise
R
R
Baldwin
D R
DR
Andrews
J M
JM
Ashby
J P
JP
Honeybourne
D
D
D001681:Biological Assay; D001980:Bronchi / Q000378:metabolism*; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009092:Mucous Membrane / Q000378:metabolism
D002511:Cephalosporins; D000077723:Cefepime