YS-822A, a new polyene macrolide antibiotic. I. Production, isolation, characterization and biological properties.
A new polyene macrolide antibiotic, YS-822A was isolated from the culture filtrate of a mutant strain H-8 of Streptoverticillium eurocidicum var. asterocidicus S-822. Whereas the original S-822 strain produced not only YS-822 substances but also teleocidin as by-product which is well-known as a strong carcinogenic promoter, the mutagenized H-8 strain produced the antibiotic with only a trace amount of teleocidin. Chemical and biological characterizations of the antibiotic revealed that YS-822A (molecular formula: C37H59NO14) is a new polyene macrolide with a wide antifungal spectrum and a low acute toxicity.
Itoh
A
A
POLA Pharmaceutical R&D Laboratory, Yokohama, Japan.
Ido
J
J
Iwamoto
Y
Y
Goshima
E
E
Miki
T
T
Hasuda
K
K
Hirota
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D004355:Drug Stability; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D018942:Macrolides; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009154:Mutation; D012995:Solubility; D013053:Spectrophotometry; D013306:Streptomycetaceae / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C066092:YS 822A