Effect of flurbiprofen on the maintenance of pupillary dilation during cataract surgery.
A randomized, double-blind clinical trial was performed to evaluate the effect of flurbiprofen sodium (0.03%), a potent prostaglandin inhibitor, on the maintenance of pupillary dilation during elective extracapsular cataract extraction. Intraoperative pupillary measurements were taken before incision, after lens extraction and following cortex aspiration. The treatment group demonstrated statistically significant maintenance of pupillary area at each stage and in total (p = 0.003). The results indicate that the inhibition of prostaglandin synthesis by flurbiprofen aids significantly in the maintenance of intraoperative pupillary dilation.
Heinrichs
D A
DA
Department of Ophthalmology, McGill University, Montreal General Hospital.
Leith
A B
AB
D000368:Aged; D000704:Analysis of Variance; D002387:Cataract Extraction; D004311:Double-Blind Method; D005127:Eye Color; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology*; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D011300:Preoperative Care; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*
D011448:Prostaglandin Antagonists; D005480:Flurbiprofen