Influence of macrolide antibiotics on the chemiluminescence of zymosan-activated human neutrophils.
No statistically significant changes in the chemiluminescence response of the whole blood were noted following in vitro treatment with 0, 2, 10, 25, or 50 micrograms/ml of erythromycin, josamycin, miomycin, roxithromycin, and spiramycin. These results suggest that these macrolide antibiotics are unlikely to impair the phagocytizing abilities of human neutrophils, in agreement with previous findings indicating their lack of influence upon neutrophil chemotaxis.
Laboratoire d'Immunotoxicologie Fondamentale et Clinique, INSERM U80-CNRS URA1177-UCBL, Faculté de Médecine Alex Carrel, Lyon, France.
R
R
Dumas
J P
JP
Brouland
R
R
Tedone
J
J
Descotes
D000900:Anti-Bacterial Agents / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D018942:Macrolides; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D015054:Zymosan / Q000097:blood / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D015054:Zymosan