Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy.
Dystrophic epidermolysis bullosa is associated with a high incidence of cutaneous squamous cell carcinoma. Despite aggressive surgical treatment, metastases occur frequently, and survival is generally poor. Chemotherapy for advanced disease has usually been avoided because of the potential for severe cutaneous toxicity. Two patients with autosomal recessive dystrophic epidermolysis bullosa and advanced squamous cell carcinoma are described. Both received cisplatin-based systemic chemotherapy without significant toxicity.
Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.
S R
SR
Lentz
R J
RJ
Raish
E P
EP
Orlowski
J M
JM
Marion
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy* / Q000556:secondary; D002405:Catheterization, Central Venous; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D004820:Epidermolysis Bullosa / Q000150:complications*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy*
D002945:Cisplatin; D005472:Fluorouracil