Concepts and trends in antiviral chemotherapy in the period of AIDS: a review.
The spread of acquired immune deficiency syndrome (AIDS) in man has accentuated the need for an effective drug against the human immunodeficiency virus (HIV). The inability of devising a vaccine to stop the spread of the virus and its ability to damage the immune response in infected individuals has increased the need for effective antiviral agents. The present review analyzes the approaches that have led to the development of effective anti-herpes simplex virus chemotherapy. The emerging concepts in antiviral chemotherapy such as interference with HIV-1 attachment to its cellular receptor CD4 are presented and the current state of research on antiviral agents is evaluated.
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
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Becker
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D004358:Drug Therapy / Q000639:trends; D006801:Humans
D000998:Antiviral Agents