8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activity.
A series of 8-substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones (2), structurally related to the imidazoacridinones (1), was synthesized and tested for cytotoxic and antineoplastic activity. Preliminary biological results indicated that the 8-OH derivatives possess the highest antitumor activity. No relationship has been found between the nature of the C-8 substituent and antitumor activity.
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
W M
WM
Cholody
S
S
Martelli
J
J
Konopa
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000166:Acridines; D000970:Antineoplastic Agents; D014230:Triazoles