In vitro effect of doxorubicin on non-proliferating and proliferating epithelial cells.
In vitro cultured mouse kidney epithelial cells were exposed for 2 hr to 0.5 microgram/ml of Doxorubicin. The proliferative activity of the cells was determined by combined DNA and total nuclear protein measurements. The sensitivity of the cells to the drug was higher in proliferating cells as compared to non-proliferating ones, that is, those exhibiting low amounts of total nuclear protein per unit DNA.
Department of Oncology, Karolinska Hospital, Stockholm, Sweden.
E
E
Baral
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G
Auer
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D004317:Doxorubicin / Q000494:pharmacology*; D004361:Drug Tolerance; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D066298:In Vitro Techniques; D007668:Kidney / Q000166:cytology; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology
D009687:Nuclear Proteins; D004317:Doxorubicin