A common mechanism of transcriptional activation by the three positive regulators, VirG, PhoB, and OmpR.
VirG, PhoB, and OmpR are positive regulators of the virulence, phosphate, and osmolarity regulons, respectively. Their target genes are attended with one or more significant blocks of similar 6-bp sequences in their regulatory regions. The distance between the block(s) and transcriptional start site varies with the target genes, but the blocks are located in a similar manner phase-specific to the promoter sequences. On the basis of these facts, we offer a novel model of transcriptional activation common to these regulators.
Laboratory of Molecular Biology, Kyoto University, Japan.
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Aoyama
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Oka
D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010710:Phosphates / Q000378:metabolism; D011401:Promoter Regions, Genetic; D014157:Transcription Factors; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D010710:Phosphates; D014157:Transcription Factors; C058483:virG protein, Shigella flexneri