Scleroderma following augmentation mammoplasty. Report of a case and review of the literature.
A 46-year-old woman developed localized scleroderma after surgical manipulation of her silicone gel-filled breast prostheses. She developed firm, shiny plaques on her legs that progressed to involve the thighs. Histopathologic examination of a deep-skin biopsy specimen confirmed the diagnosis of scleroderma. On surgical removal of the silicone implants, and their replacement with saline-filled implants, the scleroderma gradually resolved. Histopathologic examination of the removed implant capsules revealed evidence of silicone leakage. All new female patients with scleroderma should be questioned and examined regarding augmentation mammoplasty. Until prospective studies are completed on the possible association between scleroderma and silicone breast implants, it would seem prudent to use the saline-filled, elastomeric envelope-type breast implant for augmentation mammoplasty rather than the silicone gel-filled implant.
Department of Dermatology, Medical University of South Carolina, Charleston 29425-2215.
E E
EE
Sahn
P D
PD
Garen
R M
RM
Silver
J C
JC
Maize
D001940:Breast / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D012826:Silicone Elastomers / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D013518:Surgery, Plastic / Q000009:adverse effects*
D012826:Silicone Elastomers