The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations.
Amiodarone, an iodinated benzofuran derivative, is used for treatment of refractory cardiac arrhythmias. Certain features of the drug's structure resemble those of the biologically active thyroid hormone, triiodothyronine (T3). In addition, the drug has a variety of complex effects on thyroid hormone physiology, including a number of possible antagonistic effects on thyroid hormone function at the cellular level. The drug occasionally causes clinically overt hyperthyroidism and hypothyroidism. We review these effects and discuss their clinical implications.
Figge
H L
HL
Department of Pharmacy, Albany Veterans Administration Medical Center, NY.
Figge
J
J
D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D009206:Myocardium / Q000166:cytology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D013974:Thyroxine / Q000037:antagonists & inhibitors / Q000097:blood*; D014284:Triiodothyronine / Q000037:antagonists & inhibitors / Q000097:blood*
D014284:Triiodothyronine; D000638:Amiodarone; D013974:Thyroxine