Urinary excretion of digoxin-like factor (DLF) and ADH during DOCA-salt and Goldblatt 2 kidney-1 clip hypertension development.
Urinary digoxin-like factor, ADH, sodium and potassium excretion and urine osmolality were studied during the development of two pathogenically different models of hypertension, DOCA-salt (low-renin) and Gold-blatt 2 kidney-1 clip (renin-dependent). Urinary digoxin-like factor was increased in rats that were given saline (NaCl 1%) to drink, uninephrectomized-salt and DOCA-salt rats, with no significant differences between the two groups urinary ADH was elevated in DOCA-salt rats during the study, compared with uninephrectomized-salt rats. Urinary digoxin-like factor and urinary ADH were not significantly modified in Goldblatt 2 kidney-1 clip and sham-operated rats. In addition, positive correlations between digoxin-like factor urinary excretion and urinary ADH and also with sodium urinary excretion were found. These data suggest that: a) digoxin-like factor and ADH could play a role in the pathogenesis of DOCA-salt but not in Goldblatt 2 kidney-1 clip hypertension. b) A common mechanism may stimulate ADH and digoxin-like factor simultaneously. c) Digoxin-like factor plays a role in the control of urinary sodium excretion.
Vargas
F
F
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Spain.
Casanova
I
I
Haro
J M
JM
Luna
J D
JD
Garcia del Rio
C
C
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology / Q000652:urine*; D006978:Hypertension, Renovascular / Q000503:physiopathology / Q000652:urine*; D008297:Male; D045283:Natriuretic Agents / Q000652:urine*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000502:physiology; D012964:Sodium / Q000652:urine; D014667:Vasopressins / Q000652:urine*
D045283:Natriuretic Agents; D014667:Vasopressins; D003900:Desoxycorticosterone; D012964:Sodium; D012083:Renin; D011188:Potassium