Calcitonin gene-related peptide immunoreactivity in neuronal perikarya in dorsal root.
Calcitonin gene-related peptide (CGRP) has been localized in neuronal cell bodies in dorsal root ganglia (DRG) and in fibers of the dorsal horn (DH), where it may be involved in transmission of a sensory signal. The capacity of neurons from DRG and dorsal roots (DR) to produce CGRP in culture was examined in this investigation. CGRP-like immunoreactivity was observed in cultured neuronal cell bodies in the DRG and DR. CGRP-positive cell bodies in the DR explains why extirpation of the DRG fails to eliminate CGRP-positive fibers from the DH.
Department of Veterinary Anatomy, Iowa State University, Ames 50011.
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D000375:Aging; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000166:cytology / Q000254:growth & development*; D007124:Immunoenzyme Techniques; D009412:Nerve Fibers / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology*; D051381:Rats
D015740:Calcitonin Gene-Related Peptide