Familial adult T-cell leukemia/lymphoma.
Clinical and laboratory data are described for two siblings who both developed adult T-cell leukemia/lymphoma resulting from infection by human T lymphotropic virus type I (HTLV-I). These findings suggest that genetic factors or virus-specific factors may determine which HTLV-I-infected individuals will develop leukemia.
Department of Medicine, Washington University, St. Louis, MO 63110.
L
L
Ratner
N
N
Vander Heyden
E
E
Paine
D
D
Frei-Lahr
R
R
Brown
P
P
Petruska
S
S
Reddy
M D
MD
Lairmore
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000150:complications; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015458:Leukemia, T-Cell / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging