Effects of chronic beta-carotene supplementation on vitamin K status in adults.
Plasma vitamin K concentrations and prothrombin coagulation activity were determined in 26 normal adults who had received daily beta-carotene supplementation (0, 15, 30, or 60 mg) for six months. Neither plasma vitamin K nor coagulation activity were significantly decreased at any supplementation level. Thus, chronic beta-carotene supplementation, even at high daily doses, is not expected to result in clinical vitamin K deficiency. The data suggest separate mechanisms for intestinal absorption of beta-carotene and vitamin K.
Canfield
L M
LM
Department of Biochemistry, University of Arizona, Tucson 85724.
Corrigan
J J
JJ
Plezia
P M
PM
Jeter
M
M
Sayers
S
S
Alberts
D S
DS
D000368:Aged; D002338:Carotenoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D004032:Diet; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D014812:Vitamin K / Q000097:blood* / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000139:chemically induced*; D019207:beta Carotene
D019207:beta Carotene; D014812:Vitamin K; D002338:Carotenoids