The regulation of cytosolic Ca2+ concentration in a mammalian cell.
The assumptions governing the regulation of free Ca2+ in a mammalian cell are presented. There is a possibility that mitochondria, microsomes and plasma membrane play a major role, by regulation of the very low concentration of free Ca2+ in cytosol, as the signal to biochemical activities. The possibility of the loss of very high-affinity Ca2(+)-binding and the number of its sites by preparation has not been taken into consideration in previous hypotheses.
Ota
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Department of Molecular Physiological Chemistry, School of Medicine, University of Osaka, Japan.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism*; D008322:Mammals
D002118:Calcium