Glial fibrillary acidic protein immunoreactivity of chondrocytes in immature and mature teratomas.
The immunoreactivity of chondrocytes for glial fibrillary acidic protein (GFAP), other intermediate filament proteins and S-100 protein was studied in formalin-fixed paraffin-embedded sections. A total of 95 cartilage specimens were examined from five immature teratomas, 12 mature teratomas, and a teratocarcinoma. GFAP-immunoreactive chondrocytes were abundant in immature cartilages, and as the cartilages maturated, these chondrocytes decreased and became distributed peripherally. Elastic cartilage had more GFAP-immunoreactive chondrocytes than non-elastic cartilage. GFAP-immunoreactive cartilage was often located close to central nervous tissue. Immunostaining for vimentin and S-100 protein revealed extensive distribution of immunoreactive chondrocytes in immature and mature cartilages, but in mature cartilage, chondrocytes at the center had less vimentin immunoreactivity. GFAP-immunoreactive chondrocytes also showed apparent immunostaining for vimentin. There was no difference in immunohistochemical staining for the alpha and beta subunits of S-100 protein. The immunoreactivities of teratoma cartilage specimens were quite similar to those of respiratory tract cartilage.
Notohara
K
K
Department of Pathology, Okayama University Medical School, Japan.
Hsueh
C L
CL
Awai
M
M
D002356:Cartilage / Q000032:analysis* / Q000166:cytology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008479:Mediastinal Neoplasms / Q000032:analysis / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000032:analysis / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D013724:Teratoma / Q000032:analysis* / Q000473:pathology; D013736:Testicular Neoplasms / Q000032:analysis / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D005904:Glial Fibrillary Acidic Protein; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin