Importance of organisms producing broad-spectrum SHV-group beta-lactamases into the United Kingdom.
We report the isolation of three strains of Klebsiella pneumoniae sensu lato, brought into the United Kingdom by patients from Greece and Egypt, that showed plasmid-determined resistance to ceftazidime. All three produced beta-lactamases shown by DNA hybridisation studies to belong to the SHV group. One produced an enzyme that appeared to be related to, but distinguishable from, SHV-1; another SHV-2 and the third SHV-5.
Department of Microbiology, UMDS, London, UK.
K P
KP
Shannon
A
A
King
I
I
Phillips
M H
MH
Nicolas
A
A
Philippon
D015139:Blotting, Southern; D002442:Ceftazidime / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D007525:Isoelectric Focusing; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009693:Nucleic Acid Hybridization; D011815:R Factors; D006113:United Kingdom; D001618:beta-Lactamases / Q000096:biosynthesis*
D004269:DNA, Bacterial; D002442:Ceftazidime; D001618:beta-Lactamases