Is acidosis the clue to the loss of structure and functioning of the sarcolemma?
The only way for a tissue or organ to survive ischemia is by reperfusion or restoration of the blood flow. However, if the ischemic period is too long reperfusion leads to a Ca2+ overload of the myocardial cells and thereby to cell death. The question is; what are the key events during ischemia which cause this transition from reversible to irreversible injury. In this article we discuss whether acidosis may play a crucial role by inducing Ca2+ release from the sarcolemma and reorganization of membrane components especially the membrane lipids, i.e. lateral phase separation, resulting in membrane protein clustering and changes in lipid asymmetry.
Verkleij
A J
AJ
Department of Molecular Cell Biology, University of Utrecht, NL.
Post
J A
JA
Schneijdenberg
C T
CT
D000138:Acidosis / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D012508:Sarcolemma / Q000502:physiology* / Q000648:ultrastructure