Effect of sucrose on the metabolic disposition of aspartame.
Twelve normal adult subjects ingested a beverage providing 0.136 mmol aspartame/kg body wt on 2 different days. On 1 study day the beverage provided only aspartame, on the other the beverage provided both aspartame and 3.51 mmol sucrose/kg body wt. The high mean plasma phenylalanine concentrations were similar after administration of aspartame alone (158 +/- 28.9 mumol/L, mean +/- SD) and administration of aspartame plus sucrose (134 +/- 44.1 mumol/L). Evaluation of the area under the plasma concentration-time curve (AUC) for phenylalanine also showed no significant difference between groups (197 +/- 49.1 vs 182 +/- 28.3 mumol.L-1.h for aspartame alone and aspartame plus sucrose, respectively). Similarly, the high mean ratio of phenylalanine to large neutral amino acids (Phe:LNAA) in plasma did not differ significantly (0.265 +/- 0.046 for aspartame alone, 0.275 +/- 0.107 for aspartame plus sucrose). However, there was a small but significant difference between groups for the 4-h AUC values for plasma Phe:LNAA. The simultaneous ingestion of sucrose with aspartame had only minor effects on aspartame's metabolic disposition.
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.
L D
LD
Stegink
M C
MC
Brummel
T J
TJ
Persoon
L J
LJ
Filer
E F
EF
Bell
E E
EE
Ziegler
D000328:Adult; D000409:Alanine / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000097:blood; D001218:Aspartame / Q000493:pharmacokinetics*; D001224:Aspartic Acid / Q000097:blood; D001628:Beverages; D001786:Blood Glucose / Q000032:analysis; D004040:Dietary Carbohydrates / Q000493:pharmacokinetics*; D004151:Dipeptides / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010649:Phenylalanine / Q000097:blood; D013395:Sucrose / Q000493:pharmacokinetics*
D000597:Amino Acids, Branched-Chain; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004151:Dipeptides; D007328:Insulin; D001224:Aspartic Acid; D010649:Phenylalanine; D013395:Sucrose; D000409:Alanine; D001218:Aspartame