Thyroid hormone analogue SKF L-94901: effects on amino acid and carbohydrate metabolism in rat skeletal muscle in vitro.
In summary, hyperthyroidism increased the rate of glycolysis and decreased glycogen synthesis in isolated incubated rat soleus muscle preparations. SKF 901 also increased glycolysis, but the stimulation was 5-fold less than in T3-treated muscles. Hyperthyroidism increased the rate of glutamine release from skeletal muscle, but SKF 901 did not affect glutamine metabolism.
Department of Biochemistry, University of Oxford, U.K.
B
B
Leighton
G D
GD
Dimitriadis
M
M
Parry-Billings
J
J
Bond
P
P
Kemp
E A
EA
Newsholme
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose; D050260:Carbohydrate Metabolism; D005973:Glutamine / Q000097:blood; D006003:Glycogen / Q000096:biosynthesis; D006019:Glycolysis / Q000187:drug effects; D007328:Insulin / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013970:Thyronines / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; C050835:SK&F 94901; D013970:Thyronines; D014284:Triiodothyronine; D005973:Glutamine; D006003:Glycogen