p24 protein of a human T-lymphotropic virus type-I (HTLV-I) producing cell line (TCL-Kan) reacts with some normal pregnant women's sera.
Some HTLV-1 antibody carrying pregnant women, who are rated by the gelatin particle agglutination (PA) method, show no expression of HTLV-I antigen in their peripheral blood lymphocytes. Paying attention to this fact, the authors recently studied the reaction of the antibody contained in the PA-positive sera with the antigen protein used for the PA method. This study demonstrated that the protein responsible for non-specific reaction has a molecular weight of 24,000 and that the isoelectric point of this protein differs from that of HTLV-I specific protein.
Department of Obstetrics and Gynecology, Nara Medical University.
Y
Y
Ando
H
H
Hashimoto
K
K
Kakimoto
T
T
Tanigawa
I
I
Moriyama
M
M
Ichijo
D000372:Agglutination Tests; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D002461:Cell Line, Transformed; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis / Q000276:immunology*; D015486:HTLV-I Antigens / Q000032:analysis / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D011247:Pregnancy / Q000276:immunology*; D015682:Retroviridae Proteins, Oncogenic / Q000032:analysis / Q000276:immunology*
D015481:HTLV-I Antibodies; D015486:HTLV-I Antigens; D015682:Retroviridae Proteins, Oncogenic