Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial.
Seventeen patients with long-lasting idiopathic trigeminal neuralgia (ITN) were treated with either five, weekly peripheral streptomycin/lidocaine (S/L) or lidocaine alone injections, in a double blind controlled study. Eight patients responded initially to the treatment in the S/L group and three patients in the lidocaine group. Pain recurred in four patients from the S/L group within two weeks and six months following the last injection. One patient from the lidocaine group remained pain-free for eight months. At the final assessment, three patients from the S/L group and two patients from the lidocaine group remained pain-free up to 30 months. Neither treatment affected sensory functions of the injected nerves. It is concluded that S/L injections are initially effective in the treatment of ITN. In the long term, however, their effects are similar to the effects of lidocaine alone.
Oral Surgery Clinic, Faculty of Stomatology, University of Beograd, Yugoslavia.
Z
Z
Stajcić
R P
RP
Juniper
L
L
Todorović
D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008340:Mandibular Nerve; D008442:Maxillary Nerve; D008875:Middle Aged; D009407:Nerve Block; D010919:Placebos; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014276:Trigeminal Nerve; D014277:Trigeminal Neuralgia / Q000188:drug therapy*
D004338:Drug Combinations; D010919:Placebos; D008012:Lidocaine; D013307:Streptomycin