Ligand-exchange chromatography of alpha-trifluoromethyl-alpha-amino acids on chiral sorbents.
The chromatographic behaviour of some alpha-trifluoromethyl-alpha-aminoacids on L-proline- and L-hydroxyproline sorbents was studied. The retention and selectivity parameters of the separation of amino acid enantiomers on the sorbents were determined. The introduction of a CF3 [corrected] group led to an increased selectivity in the separation of amino acid enantiomers on a proline sorbent and to a decreased selectivity on a hydroxyproline sorbent.
Galushko
S V
SV
Institute of Bioorganic Chemistry, Academy of Sciences of the Ukrainian SSR, Kiev.
Shishkina
I P
IP
Soloshonok
V A
VA
Kukhar
V P
VP
D000327:Adsorption; D000596:Amino Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003300:Copper; D019327:Copper Sulfate; D006909:Hydroxyproline / Q000302:isolation & purification; D007700:Kinetics; D008024:Ligands; D011392:Proline / Q000302:isolation & purification
D000596:Amino Acids; D008024:Ligands; D003300:Copper; D011392:Proline; D019327:Copper Sulfate; D006909:Hydroxyproline