Pf155/RESA antigen is localized in dense granules of Plasmodium falciparum merozoites.
Immunoelectron microscopy demonstrated the presence of Pf155/RESA in dense granules of Plasmodium falciparum merozoites rather than in micronemes as previously suggested. Since the dense granules are released after the merozoite enters the parasitophorous vacuole, the role of Pf155/RESA in invasion and subsequent steps of parasite development may differ from that of a molecule located in the micronemes.
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
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Aikawa
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Torii
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Sjölander
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Berzins
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Perlmann
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Miller
D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D003429:Cross Reactions; D003594:Cytoplasmic Granules / Q000276:immunology* / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron; D010963:Plasmodium falciparum / Q000276:immunology* / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000032:analysis*
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum