Interactions between the yeast mitochondrial and nuclear genomes: isogenic suppressive and hypersuppressive petites differ in their resistance to the alkaloid lycorine.
In a previous paper we have shown that the alkaloid lycorine inhibits growth of rho+, mit- and rho-, strains of Saccharomyces cerevisiae, whereas strains devoid of mitochondrial DNA (rho degrees) are resistant to more than 200 micrograms/ml of the alkaloid. In this report we show that hypersuppressive petites are almost as resistant as rho degrees mutants, whereas isogenic rho- petites, which have retained longer segments of the genome, are sensitive to the drug.
Instituto Internazionale di Genetica e Biofisica, Napoli, Italy.
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Massardo
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Manna
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Del Giudice
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Wolf
D047151:Amaryllidaceae Alkaloids; D004271:DNA, Fungal / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000235:genetics; D010617:Phenanthridines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism
D047151:Amaryllidaceae Alkaloids; D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D010617:Phenanthridines; C015330:lycorine