[The anti-anginal effect of diltiazem in patients with stable exercise-induced stenocardia and vasospastic stenocardia compared with the effect of nifedipine].
Paired bicycle ergometric tests were performed in 13 patients with stable exercise-induced angina who took a single dose of diltiazem (120 mg) and nifedipine (30 mg). Four patients with vasospastic angina underwent repeat ergometrine tests along with the both drugs given in the same doses. The two drugs significantly increased exercise tolerance: exercise time was increased by 83% with diltiazem and by 41.9% with nifedipine, its capacity was elevated by 78.9 and 30.2%, respectively, the "double product" at the peak of exercise was raised by 17.0 and 18.7%, respectively). With intravenous injection of ergometrine, diltiazem and nifedipine eliminated or delayed the spastic reaction of coronary arteries in most cases.
Kocherga
E Iu
EIu
Glukhovtsev
E V
EV
Gratsianskiĭ
N A
NA
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002986:Clinical Trials as Topic; D003329:Coronary Vasospasm / Q000150:complications*; D004110:Diltiazem / Q000627:therapeutic use*; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D004110:Diltiazem; D009543:Nifedipine
Antianginal'nyĭ éffekt diltiazema u bol'nykh so stabil'noĭ stenokardieĭ napriazheniia i vazospasticheskoĭ stenokardieĭ v sravnenii s vliianiem nifedipina.