Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli.
Vanillin and its isomer o-vanillin have an effect on the adaptive and SOS responses, as well as mutagenesis, induced in Escherichia coli by N-methyl-N-nitrosourea (MNU) and UV irradiation, potentiating in some cases and suppressing in others. o-Vanillin markedly inhibited the MNU-induced adaptive response, while both vanillins potentiated the UV-induced SOS response. These phenomena appear to be responsible for the comutagenic or antimutagenic role of these chemicals in MNU and UV mutagenesis.
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
K
K
Takahashi
M
M
Sekiguchi
Y
Y
Kawazoe
D001547:Benzaldehydes / Q000494:pharmacology*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics*; D015870:Gene Expression; D005798:Genes, Bacterial; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D008770:Methylnitrosourea / Q000494:pharmacology; D009154:Mutation; D010957:Plasmids; D013014:SOS Response, Genetics; D014466:Ultraviolet Rays
D001547:Benzaldehydes; D004269:DNA, Bacterial; C060843:2-vanillin; D006147:Guanine; D008770:Methylnitrosourea; C008449:O-(6)-methylguanine; C100058:vanillin