Synthesis of biologically active derivatives of D-glucosamine-4-phosphate and 1-thyminyl-D-glucosamine-4,6-disulfate.
New 1-thyminyl-D-glucosamine-4-phosphate and 1-thyminyl-D-glucosamine-4,6-disulfate derivatives were synthesized. The 1-thyminyl-D-glucosamine-4,6-disulfate derivative showed antiviral activity against HIV.
Idegami
K
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Ikeda
K
K
Achiwa
K
K
D000998:Antiviral Agents / Q000138:chemical synthesis*; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005958:Glucosephosphates / Q000138:chemical synthesis / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000998:Antiviral Agents; D005958:Glucosephosphates; C055459:glucosamine 4-phosphate; C065846:1-thyminylglucosamine-4,6-disulfate; D005944:Glucosamine; D013941:Thymine