The evolution of alpha/beta barrel enzymes.
Of the enzymes whose structure is known, roughly one out of ten has an eight-stranded alpha/beta barrel domain. Structural and chemical evidence suggests that all of these domains may have diverged from a common ancestor.
Department of Chemistry, Pennsylvania State University, University Park 16802.
G K
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Farber
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Petsko
D000595:Amino Acid Sequence; D005075:Biological Evolution; D004798:Enzymes / Q000235:genetics*; D007535:Isomerases / Q000235:genetics; D008190:Lyases / Q000235:genetics; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000235:genetics; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014305:Triose-Phosphate Isomerase / Q000235:genetics
D004798:Enzymes; D010088:Oxidoreductases; D008190:Lyases; D007535:Isomerases; D014305:Triose-Phosphate Isomerase