Autoantibodies to lamins in rheumatoid arthritis.
The presence of autoantibodies reacting with lamins A and C was demonstrated in sera from 2 patients with rheumatoid arthritis (RA). One patient developed antilamin antibodies several years after being diagnosed as having RA; she was also found to have chronic active hepatitis. The second patient had severe nodular RA. We describe the other serologic findings in these 2 patients and discuss the relationships between antilamin antibodies and RA.
Department of Rheumatology, Toulouse Purpan University, France.
S
S
Lassoued
F
F
Oksman
B
B
Fournie
F
F
Danon
A
A
Fournie
K
K
Lassoued
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology; D034882:Lamins; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007132:Immunoglobulin Isotypes; D034882:Lamins; D009687:Nuclear Proteins