Pathways to acetyl-CoA formation in Candida albicans.
The supply of acetyl units from the mitochondrion to the cytosol of Candida albicans appears to be dependent only upon the activity of carnitine acetyltransferase (CAT). The enzyme ATP:citrate lyase (ACL), the major source of acetyl units in oleaginous yeasts, is absent from C. albicans in both the mycelial and yeast forms. There appears to be no other active translocation of acetate or acetyl groups except via the action of carnitine acetyltransferase.
Department of Applied Biology, University of Hull, U.K.
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Sheridan
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Ratledge
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D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism*; D002176:Candida albicans / Q000201:enzymology*; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008928:Mitochondria / Q000378:metabolism
D000105:Acetyl Coenzyme A; D002332:Carnitine O-Acetyltransferase; D001275:ATP Citrate (pro-S)-Lyase