Twelve-hour IOP control obtained by a single dose of timolol/pilocarpine combination eye drops.
The 12 h IOP control achieved by a single application of a newly developed ophthalmic solution containing 0.5% timolol and 2% resp. 4% pilocarpine was compared with that obtained by 1 dose of timolol 0.5% alone in 33 patients with manifest open angle glaucoma or ocular hypertension. The combined solutions gave a significantly better 12 h IOP control, evidenced by both a reduced mean diurnal IOP and a decreased frequency of larger pressure peaks.
Eye Department, University Hospital, Trondheim, Norway.
K T
KT
Løfors
G
G
Høvding
L
L
Viksmoen
H
H
Aasved
B
B
Bergaust
T
T
Bulie
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009798:Ocular Hypertension / Q000188:drug therapy*; D010862:Pilocarpine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*
D010862:Pilocarpine; D013999:Timolol