Salivary peptide P-C modulates both insulin and glucagon release from isolated perfused rat pancreas.
The effect of salivary peptide P-C, saliva-derived peptide on glucose-induced insulin release was studied using perfused rat pancreas. Salivary peptide P-C (194 nM) remarkably potentiated glucose (8.3 and 16.7 mM)-induced insulin release, whereas the same concentration suppressed arginine (10 mM)-induced glucagon release. Both effects of salivary peptide P-C occurred in a concentration-dependent manner. These findings suggest that salivary peptide P-C may modulate both the levels of insulin and glucagon in vivo.
Kimura
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Nakashima
N
N
Kimura
I
I
D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008969:Molecular Sequence Data; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D055232:Proline-Rich Protein Domains; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism*; D055273:Salivary Proline-Rich Proteins
D007328:Insulin; D010455:Peptides; D055273:Salivary Proline-Rich Proteins; C524743:salivary peptide P-C; D005934:Glucagon; D001120:Arginine; D005947:Glucose