Synthesis of a new chemically stable prostacyclin analogue with high and long-lasting activity.
The chemically stable prostacyclin analogue (Z)-4,5-didehydroisocarbacyclin analogue (6) has been synthesized. Compound 6 given intravenously or orally is very potent in inhibiting platelet aggregation.
Iseki
K
K
Research Center, Mitsubishi Kasei Corporation, Yokohama, Japan.
Kanayama
T
T
Hayasi
Y
Y
Shibasaki
M
M
D000818:Animals; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D051381:Rats
D010975:Platelet Aggregation Inhibitors; C065820:4,5-didehydroisocarbacyclin; D011464:Epoprostenol