Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.
Production of the eosinophilogenic cytokines interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), and IL-5 by mitogen-stimulated peripheral blood mononuclear cells was compared between 11 noneosinophilic individuals and seven patients with helminth-induced eosinophilia. Both the kinetics and quantities of IL-3 and GM-CSF were similar in the two groups. In contrast, IL-5 production at both the protein and the mRNA level was markedly greater in the eosinophilic patients, an observation suggesting that IL-5 may be particularly important in mediating the selective eosinophilia seen in filarial and other helminth infections.
Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892.
A P
AP
Limaye
J S
JS
Abrams
J E
JE
Silver
E A
EA
Ottesen
T B
TB
Nutman
D000328:Adult; D015152:Blotting, Northern; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology / Q000469:parasitology*; D005260:Female; D005368:Filariasis / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000096:biosynthesis; D006801:Humans; D007377:Interleukin-3 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D008118:Loiasis / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007377:Interleukin-3; D015848:Interleukin-5; D008934:Mitogens; D012333:RNA, Messenger; D016178:Granulocyte-Macrophage Colony-Stimulating Factor