An inhibitor of T lymphocyte blastogenesis derived from the unfertilized ova of Shad (Alosa sapidissima).
Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis. The inhibitor has an estimated molecular weight of 10,000-30,000 Da, is heat stable, non dialyzable, and resistant to protease digestion and periodate oxidation. Although the inhibitor functions at an early metabolic event in T lymphocyte mitogenesis, it does not appear to interfere with thymidine transport, antagonize lectin binding to lymphocyte surface receptors, or interfere with the function of an essential serum component in the cell culture media.
Sheid
B
B
Department of Pharmacology, State University of New York Health Science Center, Brooklyn 11203.
Nobiletti
J B
JB
Prat
J C
JC
D000818:Animals; D002478:Cells, Cultured; D005399:Fishes; D006133:Growth Substances / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010063:Ovum / Q000032:analysis*; D010447:Peptide Hydrolases; D011489:Protein Denaturation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D006133:Growth Substances; D010447:Peptide Hydrolases