Long-lasting elevation of alanine in brain produced by the antidepressant phenelzine.
Time- and dose-response studies were conducted to determine the effects of the antidepressant and antipanic drug phenelzine (a monoamine oxidase inhibitor) on whole brain levels of the aliphatic amino acid alanine. At a dose of phenelzine of 15 mg/kg IP, there was a significant increase in brain levels of alanine up to 16 hr after drug administration. Dose studies at 4 hr indicated that the alanine elevation after phenelzine was a dose-dependent effect.
Wong
J T
JT
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Baker
G B
GB
Coutts
R T
RT
Dewhurst
W G
WG
D000409:Alanine / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010624:Phenelzine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D010624:Phenelzine; D000409:Alanine