Capillary leakage complicated by compartment syndrome necessitating surgery.
A single episode of systemic capillary leak syndrome is reported in a HIV-positive patient. The shock had necessitated the infusion of large amounts of fluid with concomitant diffuse swelling and weight gain leading to compartment syndrome of both legs. This required surgical relief. The initial high hematocrit (62%) and low serum protein concentration (48 g/l) with normal factor V (molecular weight above 300,000) concentrations are the hallmark of capillary leak when they are associated with hypovolemic shock. It must be emphasized that fluid resuscitation may worsen the muscle damage with ultimate compartment syndrome. Therefore, it appears reasonable to monitor muscular pressure during volume expansion in patients with capillary leak syndrome, severe shock and muscular swelling.
Service de Réanimation Polyvalente, Hôpital Saint-Antoine, Paris, France.
B
B
Guidet
B
B
Guerin
E
E
Maury
G
G
Offenstadt
P
P
Amstutz
D000328:Adult; D002199:Capillary Permeability; D003161:Compartment Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D004224:Diterpenes; D005440:Fluid Therapy / Q000009:adverse effects*; D046934:Ginkgolides; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006801:Humans; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D012206:Rhabdomyolysis / Q000209:etiology; D012769:Shock / Q000150:complications / Q000175:diagnosis / Q000628:therapy*
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B