HLA-B27 and acute anterior uveitis.
This article reviews the ophthalmological significance of the association between HLA-B27 and acute anterior uveitis (AAU). HLA-B27 determination should be performed in all cases of acute anterior uveitis (AAU), since B27+ AAU is a distinct kind of uveitis. All B27+ AAU patients have to be referred to a rheumatologist because half of these patients has ankylosing spondylitis or Reiter's syndrome. The structure and physiological role of HLA-class I molecules is now known. It is probable that the role of HLA-B27 in the pathogenesis of AAU will be revealed in the coming years.
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
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Feltkamp
D000208:Acute Disease; D016918:Arthritis, Reactive / Q000150:complications / Q000276:immunology; D005544:Forecasting; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D015796:HLA-B27 Antigen / Q000097:blood* / Q000235:genetics; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000276:immunology; D014606:Uveitis, Anterior / Q000150:complications / Q000276:immunology*
D006680:HLA Antigens; D015796:HLA-B27 Antigen