Structure of the granulocyte macrophage colony-stimulating factor gene in patients with the myelodysplastic syndromes.
DNA samples from 76 patients with the myelodysplastic syndromes, including 10 cases with a partial deletion of the long arm of chromosome 5 (5q-), were examined for structural rearrangements of the granulocyte/macrophage colony-stimulating factor (GM-CSF) gene. No abnormalities were detected, indicating that structural aberrations of this gene are not a feature of the myelodysplastic syndromes.
Leukaemia Research Fund Molecular and Cytogenetic Haematology Unit, John Radcliffe Hospital, Headington, Oxford, England.
J
J
Boultwood
G
G
Abrahamson
V J
VJ
Buckle
K
K
Rack
D G
DG
Oscier
J S
JS
Wainscoat
D003115:Colony-Stimulating Factors / Q000235:genetics*; D005784:Gene Amplification; D005796:Genes; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics*
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor