[The mechanisms of the action of radioprotectors of different chemical classes in the intestinal syndrome].
Some thiazole, triazole, thiadiazine, and heterylalkane derivatives increased the lifespan of gamma-irradiated (9-14 Gy) mice up to 6-22 days (as opposed to 4.1 days in the irradiated control). The efficacy of chemical agents within the dose range mentioned above was mainly associated with protecting intestinal epithelium stem cells the number of which was 4-9 times as large as that of nontreated animals. There was a moderate (40-50%) decrease in oxygen consumption under the effect of the most active radioprotectors.
L N
LN
Rasina
O N
ON
Chupakhin
M V
MV
Chibiriak
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects; D007410:Intestinal Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D007422:Intestines / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D013234:Stem Cells / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents
O nekotorykh mekhanizmakh deĭstviia radioprotektorov raznykh khimicheskikh klassov pri kishechnom sindrome.