Small-field stereotactic external-beam radiation therapy of intracranial lesions: fractionated treatment with a fixed-halo immobilization device.
Current techniques of stereotactic, small-field, external-beam irradiation with linear accelerators require treatment with a single fraction or only a few fractions of radiation with large single doses per fraction. Using a radiolucent halo that remained affixed to the cranium with skin-piercing screws, the authors treated 24 patients with a multifraction technique for benign and malignant brain lesions. The objective of this study was to ascertain the feasibility of maintaining the halo in place for a prolonged, multifraction course of treatment, not to assess treatment efficacy. The halo was affixed for multifraction treatments lasting 19-58 days (mean, 38.7 days; median, 40.0 days) and delivered in 16-31 fractions (mean, 24.9 fractions; median, 25.5 fractions). Two of 24 patients experienced superficial skin infection at the site of fixation, but no other significant acute or chronic toxicity attributable to the stereotactic halo was observed. The authors conclude that stereotactic, small-field, precision irradiation can be accomplished with multiple fractions as well as with a single fraction.
Department of Radiation Oncology, University of Miami School of Medicine, FL 33101.
J G
JG
Schwade
P V
PV
Houdek
H J
HJ
Landy
J L
JL
Bujnoski
A A
AA
Lewin
A A
AA
Abitol
C F
CF
Serago
V J
VJ
Pisciotta
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002648:Child; D005260:Female; D006801:Humans; D007103:Immobilization; D008297:Male; D008722:Methods; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects / Q000295:instrumentation*; D011879:Radiotherapy Dosage; D013238:Stereotaxic Techniques / Q000295:instrumentation*