[Randomized comparative study of secondary prevention of Pneumocystis carinii pneumonia in patients with acquired immunologic deficiency syndrome].
Pneumocystis carinii pneumonia is one of the most frequent infectious complications in patients with the acquired immunodeficiency syndrome (AIDS). A prospective trial was initiated to compare azidothymidine alone with azidothymidine plus aerosolized pentamidine as a secondary prophylaxis for pneumocystis carinii pneumonia. 27 patients (24 male, three female, average age 39 years) were enrolled, 14 patients receiving azidothymidine and pentamidine aerosol and 13 azidothymidine alone. After 166 days of follow-up, this trial had to be terminated prematurely, since the efficacy of pentamidine aerosol in the prevention of pneumocystis carinii pneumonia was clearly demonstrated in two recently published studies. Two patients died during the study period, one in either group, but neither due to pneumocystis carinii pneumonia. Two patients developed histologically proven pneumocystis carinii pneumonia; both patients were allocated to the azidothymidine arm. Pneumocystis carinii pneumonia was suspected clinically but not proven in four patients, three were randomized in the azidothymidine arm. Pentamidine was well tolerated and produced no severe side effects. The sample size is too small to draw definitive conclusions concerning the efficacy of pentamidine aerosol in AIDS patients.
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Prophylaxe-Studiengruppe Pneumocystis-carinii-Pneumonie, Paul-Ehrlich-Gesellschaft für Chemotherapie, e.V.
Elsing
C
C
Ruhnke
M
M
Franke
M
M
Schrappe-Bächer
M
M
Stellbrink
H J
HJ
Weiss
R
R
Noack
H
H
Petri
M
M
Lode
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000280:Administration, Inhalation; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010419:Pentamidine / Q000008:administration & dosage*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D015215:Zidovudine / Q000008:administration & dosage
D015215:Zidovudine; D010419:Pentamidine
Randomisierte Vergleichsuntersuchung zur Sekundärprophylaxe einer Pneumocystis-carinii-Pneumonie bei Patienten mit erworbenem Immundefektsyndrom.