[The marine bacterium Alteromonas piscicida--a producer of enzymes with thrombolytic action].
The ability of marine bacteria A. piscicida to produce exoproteases that were able to lyse human blood clots has been studied. Optimal conditions for biosynthesis of these enzymes have been found. The enzyme has been partially purified. In concentration of 1 mg/ml it has activity corresponding to that of 500 micrograms/l plasmine and 100 micrograms/ml trypsine. The enzyme activity was completely inhibited after incubation in human blood plasma.
Demina
N S
NS
Veslopolova
E F
EF
Gaenko
G P
GP
D003470:Culture Media; D004353:Drug Evaluation, Preclinical; D020689:Exopeptidases; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008386:Marine Biology; D010447:Peptide Hydrolases / Q000302:isolation & purification / Q000494:pharmacology*; D011548:Pseudomonadaceae / Q000201:enzymology*
D003470:Culture Media; D005343:Fibrinolytic Agents; D020689:Exopeptidases; D010447:Peptide Hydrolases
Morskaia bakteriia Alteromonas piscicida--produtsent fermentov tromboliticheskogo deĭstviia.