Methotrexate side-effects.
Methotrexate is by far the most widely used cytotoxic drug in psoriasis. Treatment requires normal kidney, liver and bone-marrow function, and pregnancy and alcohol abuse are absolute contraindications. Serious toxic reactions are recognized, but can be avoided if the drug is used correctly. The most important side-effects are haematopoietic and hepatotoxic. It is well established that long-term methotrexate can induce liver damage which, in a number of patients, may lead to fibrosis or cirrhosis. Recent studies have, however, documented that the methotrexate-induced liver cirrhosis is not aggressive. Interaction can occur with a number of drugs; serious problems in particular may arise with concomitant use of sulphonamides and salicylates. The recommended guidelines for methotrexate use in psoriasis should be followed and patients given clear instructions.
Zachariae
H
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Department of Dermatology, Marselisborg Hospital, University of Aarhus, Denmark.
D000328:Adult; D000368:Aged; D002648:Child; D004347:Drug Interactions; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D008103:Liver Cirrhosis / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D010353:Patient Education as Topic; D011247:Pregnancy; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000139:chemically induced
D008727:Methotrexate