Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder?
It seems unlikely that a solitary disturbance in serotonin function can fully account for the pathophysiology of obsessive compulsive disorder. The authors propose that some forms of obsessive compulsive disorder, e.g., obsessive compulsive disorder with a history of Tourette's syndrome, may involve a relative or absolute derangement in both brain serotoninergic and dopaminergic systems. A role for dopamine in the pathophysiology of obsessive compulsive disorder is supported by a review of the preclinical and clinical evidence. Additional studies are needed to more directly evaluate dopamine function in patients with obsessive compulsive disorder.
Yale University, School of Medicine, Department of Psychiatry, New Haven, CT.
W K
WK
Goodman
C J
CJ
McDougle
L H
LH
Price
M A
MA
Riddle
D L
DL
Pauls
J F
JF
Leckman
D004298:Dopamine / Q000502:physiology*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology; D005879:Tourette Syndrome / Q000503:physiopathology
D012701:Serotonin; D004298:Dopamine