Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin.
To evaluate the difluorinated quinolone lomefloxacin in murine typhoid, mice were inoculated intraperitoneally with the LT-2 strain of Salmonella typhimurium and treated with graded doses of the drug given once daily by an orogastric needle. Treatment with lomefloxacin for seven days reduced mortality with a 50% effective dose of 2.5-7.8 mg/kg/day. When given once daily for three days, doses greater than or equal to 5 mg lomefloxacin/kg/day caused significant reductions in splenic counts of S. typhimurium and prevented the inflammatory response to infection in the spleen.
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
T
T
Butler
M
M
Cartagenova
D
D
Dunn
D042462:4-Quinolones; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones; D006207:Half-Life; D051379:Mice; D015363:Quinolones; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000401:mortality; D012486:Salmonella typhimurium
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin