Inherited predisposition to cancer.
In a minority of cancers, the family history, and sometimes characteristic abnormalities in growth or development of target tissues, suggests strong inherited predisposition. There may also be a much larger number of cases who are less strongly predisposed, with important implications for screening and prevention; because there is usually no family history, however, the recognition and investigation of these cases poses a major problem.
Ponder
B A
BA
CRC Human Cancer Genetics Research Group, Department of Pathology, University of Cambridge, UK.
D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D010375:Pedigree