[Psychotropic effects of captopril? Effect of a short-term treatment on reaction and concentration capabilities and space perception ability].
In a randomized, placebo-controlled double-blind trial 22 healthy normotensive young men (mean age 25 +/- 1.7 years) were given a single oral dose of 50 mg captopril or a placebo (11 subjects each). To test their concentration and proficiency, as well as spatial perception and reaction capacity four tests were administered: attention, concentration, hose-pattern perception and "Bonn Determination Device". Captopril had no negative effects on any test performances either one or five hours after its administration, or after a single daily dose for seven days. There was only a small, statistically not significant, difference in the effect on blood pressure between captopril and the placebo.
Innere Medizin, Medizinische Universitätsklinik Bonn.
H
H
Rüddel
L
L
Napp-Zinn
H
H
Schächinger
H
H
May
W
W
Langewitz
D000328:Adult; D001288:Attention / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D011930:Reaction Time / Q000187:drug effects*; D013028:Space Perception / Q000187:drug effects*
D002216:Captopril
Psychotrope Wirkungen von Captopril? Einfluss einer Kurzzeitbehandlung auf die Reaktions- und Konzentrationsfähigkeit sowie das räumliche Vorstellungsvermögen.