Reciprocal t(14;19)(q32.3;q13.1) in a patient with B-cell lymphoma.
A patient with B-cell lymphoma with a chromosome rearrangement of t(14;19)(q32.3;q13.1) is reported. This patient had leukemic features and an aggressive clinical course. The histopathologic diagnosis was malignant lymphoma, small noncleaved cell. Chromosome analysis of the cells from a cervical lymph node and peripheral blood showed a reciprocal translocation between chromosome 14 with a break at band q32.3 and chromosome 19 with a break at band q13.1, to which the bcl-3 gene has been mapped. Monoclonal rearrangement of the JH gene was detected by Southern blot analysis. However, we could not detect rearrangement of the bcl-3 gene. This case also had a t(2;8)(q13;q24.1), but the c-myc gene remained in its germline. This is the first case with the reciprocal t(14;19) and 8q24 chromosomal breakpoint in a B-cell lymphoid malignancy.
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
S
S
Tanaka
H
H
Nishigaki
H
H
Nakagawa
T
T
Okuda
K
K
Nishida
S
S
Tsuda
M
M
Taniwaki
H
H
Imanishi
S
S
Misawa
K
K
Kashima
D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic