Effect of epinephrine on intrathecal fentanyl analgesia in patients undergoing postpartum tubal ligation.
Eighty women receiving spinal anesthesia for postpartum tubal ligation were entered into a double-blind, randomized protocol studying the effects of epinephrine on intrathecal fentanyl-induced postoperative analgesia. All patients received 70 mg hyperbaric lidocaine with either 0.2 mg epinephrine (LE), 10 micrograms fentanyl (LF), epinephrine and fentanyl (LFE), or 0.4 ml saline (L). Onset and regression of anesthesia, degree of intraoperative comfort, incidence of pruritus, and extent of postoperative analgesia were evaluated. The simultaneous administration of epinephrine and fentanyl prolonged the duration of complete analgesia (137 +/- 47 min (LFE); 76 +/- 32 min (LE); 85 +/- 44 min (LF); 65 +/- 36 min (L)) and the duration of effective analgesia (562 +/- 504 min (LFE); 227 +/- 201 min (LE); 203 +/- 178 min (LF); 198 +/- 342 min (L)). Administration of epinephrine decreased the incidence of pruritus associated with intrathecal fentanyl (1/18 (LFE); 1/21 (LE); 8/19 (LF); 2/19 (L)).
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore 21201-1595.
A M
AM
Malinow
B L
BL
Mokriski
M K
MK
Nomura
M A
MA
Kaufman
J A
JA
Snell
G D
GD
Sharp
R A
RA
Howard
D000328:Adult; D000775:Anesthesia, Spinal; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl; D006801:Humans; D007278:Injections, Spinal; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D010149:Postoperative Pain / Q000517:prevention & control*; D049590:Postpartum Period; D016032:Randomized Controlled Trials as Topic; D013246:Sterilization, Tubal
D008012:Lidocaine; D005283:Fentanyl; D004837:Epinephrine