The penetration of ceftriaxone into human brain tissue.
The cerebral penetration of ceftriaxone in patients who underwent surgery for cerebral tumours was investigated. Seventeen patients received 2 g of ceftriaxone given intravenously 2 to 13 h before blood and brain samples were taken. Antibiotic levels were determined by an agar-well diffusion method. Cerebral ceftriaxone concentrations ranged from 0.3 to 12 micrograms/g, with a mean value of 1.63 micrograms/g. These values were less than 2% of corresponding serum concentrations, but enough to inhibit 75% of bacterial strains recently isolated from brain abscesses in our unit.
Lucht
F
F
Department of Infectious Diseases, Hopital Bellevue, CHRU-Saint-Etienne, France.
Dorche
G
G
Aubert
G
G
Boissier
C
C
Bertrand
A M
AM
Brunon
J
J
D000328:Adult; D000368:Aged; D001681:Biological Assay; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000601:surgery; D002443:Ceftriaxone / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002443:Ceftriaxone