Endocrine pancreatic secretion in patients after acute pancreatitis.
In 14 nonobese patients after acute pancreatitis and with normal oral glucose tolerance, the response of insulin, C-peptide, and pancreatic glucagon after 100 g of oral glucose was assessed. The curves of insulin and C-peptide were significantly raised compared with those of controls, and no difference was found between the response of patients with a negative (n = 8) and a positive (n = 6) family history of type II diabetes. The curves of pancreatic glucagon did not differ from those found in controls. Our results indicate that a normal response to glucose after recovery from an attack of acute pancreatitis is maintained at the cost of increased insulin secretion.
Research Department of Medicine, Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
R
R
Stastná
L
L
Karasová
J
J
Svácek
R
R
Petrásek
L
L
Winkler
V
V
Lánská
I
I
Skála
J
J
Malý
D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism*; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005934:Glucagon