[Delta hepatitis as a mixed infection].
Radioimmunoassay of 247 patients revealed in their sera 8 cases of anti-delta agents. On the basis of testing of HBV infection markers the authors revealed three cases of coinfection and five cases of delta superinfection. A fatal case of fulminant hepatitis with development of acute liver dystrophy was observed in one patient with coinfection. In two other patients the course of the disease was severe but ended in recovery. Superinfection with delta agent resulted in a progression of the disease with early formation of chronic active hepatitis. This form chronic disease was characterized by a malignant course and proved resistant to immunosuppressive therapy. The clinical and biochemical signs of coinfection and delta superinfection are discussed.
Fedorchenko
S V
SV
Vovk
A D
AD
Vozianova
S V
SV
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000175:diagnosis*; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D003699:Hepatitis D / Q000150:complications / Q000175:diagnosis*; D003698:Hepatitis Delta Virus / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D011863:Radioimmunoassay
D015415:Biomarkers; D006508:Hepatitis Antibodies; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D007075:Immunoglobulin M
Del'ta-gepatit kak smeshannaia infektsiia.