Correspondences between the activity of the renin-angiotensin system and the erythrocyte Na+ transport abnormalities in hypertension.
Plasma renin activity and the relationship of renin activity and sodium excretion were analyzed in 50 untreated essential hypertensives classified according to their erythrocyte Na+ transport abnormalities. Renin activity was inappropriately high in 7 patients with increased activity of Na+,Li+ countertransport, inappropriately low in 12 patients with decreased activity of Na+,K+,Cl- cotransport and normal in 31 patients without either Na+ transport abnormalities. These results suggest that there are correspondences between the activity of the renin-angiotensin system and the main Na+ transport abnormalities present in erythrocytes of patients with essential hypertension.
Department of Medicine, University of Zaragoza, Spain.
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Arrázola
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Díez
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017920:Antiporters; D001692:Biological Transport; D002352:Carrier Proteins / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D012964:Sodium / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters
D017920:Antiporters; D002352:Carrier Proteins; D028021:Sodium-Potassium-Chloride Symporters; C045885:sodium-lithium countertransporter; D012964:Sodium; D012083:Renin