Adoptive immune responses of chicken immunocytes in embryonic and neonatal hosts.
The adoptive immune capacities of peripheral blood immunocytes from unprimed juvenile B haplotype-matched donors were compared in late embryonic and neonatal chick hosts. Adoptive PFC counts of immunocytes that responded to mouse erythrocytes (MER+) were high in late embryo and newly hatched chick hosts but somewhat less in older neonatal hosts. In contrast, the PFC levels of immunocytes that responded to sheep erythrocytes (SER+) were high in late embryo and older neonatal hosts, but conspicuously depressed in newly hatched chick hosts. The addition of spleen cells from neonatal 4- to 7-day chick donors to the donor cell inoculum appeared to enhance the adoptive immune responses of MER+ cells in embryonic hosts.
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Zoology Department, University of Oklahoma, Norman 73019.
D000375:Aging / Q000276:immunology; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D002642:Chick Embryo / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D016219:Immunotherapy, Adoptive; D051379:Mice; D008809:Mice, Inbred C3H; D012756:Sheep