[The protein content and cathepsin D activity of the mandibular bone in rats during fracture healing].
Soluble and total protein content and cathepsin D activity were measured in rat mandibular bone tissue during healing of a fracture treated with proteolytic enzymes (andecalin) or protease inhibitors (contrykal) electrophoresis. Contrykal essentially elevated collagen content in mandibular bone tissue and reduced lysosomal enzymes activity. Andecalin had no noticeable effect on the levels of total protein and collagen, but it significantly increased the activity of cathepsin D. The findings evidence that local contrykal electrophoresis in the focus of injury creates an effective concentration of the drug that enhances the fracture healing and prevents the development of pyoinflammatory complications.
Vakulenko
V I
VI
Sapargel'dyev
N B
NB
Golub
G B
GB
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002402:Cathepsin D / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000378:metabolism*; D008337:Mandibular Fractures / Q000188:drug therapy / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000627:therapeutic use; D011506:Proteins / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D011480:Protease Inhibitors; D011506:Proteins; D010447:Peptide Hydrolases; D002402:Cathepsin D
Soderzhanie belka i aktivnost' katepsina D v kosti nizhneĭ cheliusti krys pri zazhivlenii pereloma.