[inflammatory reaction and laboratory tests: granulocyte elastase].
The role in the so called inflammatory response of the polymorphonuclear granulocyte elastase (PMN elastase, EC 3.4.21.37) has been well established. Elastase, a neutral protease stored in the lysosomes of neutrophils and monocytes, is extracellularly released during the process of phagocytosis, and bound to alpha 1-proteinase inhibitor (E-alpha 1-PI complex). This complex can be quantified by an immunoassay. PMN elastase has been shown to be a sensitive and specific marker for the early diagnosis of inflammation and prediction of inflammatory complications.
Department of Clinical Laboratory, Omiya Medical Center, Jichi Medical School.
I
I
Sakurabayashi
K
K
Shimanuki
A
A
Shinpo
S
S
Ishii
D004796:Clinical Enzyme Tests; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D010196:Pancreatic Elastase / Q000097:blood*
D010196:Pancreatic Elastase