Prenatal diagnosis and postnatal follow-up of a child with two de novo unrelated balanced reciprocal translocations.
Two unrelated, apparently balanced, reciprocal translocations involving chromosomes 3 and 17, and 10 and 15 were found in cultured amniotic fluid cells from a 41-year-old 10-gravida. Chromosome analysis of peripheral blood lymphocytes of both parents revealed normal karyotypes. Post-partum examination of lymphocyte cultures from the proband confirmed the chromosome rearrangements. The child showed normal development during follow-up examinations up to the age of 4 years.
Pruggmayer
M
M
Institut für Humangenetik, Universität Göttingen, F.R.G.
Zoll
B
B
Leipoldt
M
M
Thies
U
U
D000328:Adult; D000649:Amniocentesis; D002879:Chromosomes, Human, Pair 10; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D014178:Translocation, Genetic