Preanesthetic medication with rectal midazolam in children undergoing dental extractions.
Three different dosages (0.25, 0.35, and 0.45 mg/kg) of rectally administered midazolam were compared with each other and with placebo for preanesthetic medication in children undergoing dental extractions. Eighty patients between the ages of 2 and 10 years were randomly allocated into four groups in this double-blind study. The results from this trial show that 30 minutes after rectal administration of all doses of midazolam, good anxiolysis, sedation, and cooperation were obtained in most patients. A high prevalence (23%) of disinhibition reactions was observed, particularly in the 0.45 mg/kg group. For this reason, 0.25 or 0.35 mg/kg appears to be the dose of choice when rectal midazolam is used for premedication in children.
Roelofse
J A
JA
Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
van der Bijl
P
P
Stegmann
D H
DH
Hartshorne
J E
JE
D000285:Administration, Rectal; D000704:Analysis of Variance; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D011229:Preanesthetic Medication; D016032:Randomized Controlled Trials as Topic; D014081:Tooth Extraction
D008874:Midazolam