An avian B-lymphocyte protein associated with beta 2-microglobulin.
A member of the family of beta 2-microglobulin (beta 2m)-associated cell surface glycoproteins was identified by the CB3 monoclonal antibody. The Mr 50,000 heavy chain of the CB3 antigen differs from conventional class I heavy chains (Mr 45,000) in the extent of glycosylation, charge, and peptide composition. Because of its selective expression on avian B cells and its similarity to mammalian class I-like molecules, we speculate that the CB3 antigen may play a role in T- and B-cell interactions,
Department of Pediatrics, University of Alabama, Birmingham 35294.
J M
JM
Pickel
C L
CL
Chen
M D
MD
Cooper
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000378:metabolism*; D001402:B-Lymphocytes / Q000502:physiology*; D002060:Bursa of Fabricius / Q000254:growth & development / Q000276:immunology; D002645:Chickens; D006023:Glycoproteins / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D007526:Isoelectric Point; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D011233:Precipitin Tests; D001613:beta 2-Microglobulin / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; D046911:Macromolecular Substances; D001613:beta 2-Microglobulin