Long-term effect of acetazolamide in a patient with retinitis pigmentosa.
The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema. In addition to reduction of macular edema and some improvement of central vision, they found an unexpected progressive increase in extrafoveal retinal sensitivity with prolonged medication. It is proposed that the therapeutic effect is mediated by alteration of retinal pigment epithelial function and that disturbed polarity is restored to a more normal state.
Department of Clinical Ophthalmology, University of London, England.
J C
JC
Chen
F W
FW
Fitzke
A C
AC
Bird
D000086:Acetazolamide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008269:Macular Edema / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D011601:Psychophysics; D012160:Retina / Q000187:drug effects; D012174:Retinitis Pigmentosa / Q000150:complications / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects
D000086:Acetazolamide