Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques.
The striking similarities between simian immunodeficiency virus (SIV)-induced disease in macaque monkeys and HIV-induced disease in humans make the SIV-induced macaque monkey an extraordinarily important model for the study of AIDS. The most significant difference between these lentivirus-induced syndromes is the more rapid progression of disease in SIV-infected monkeys. The immunologic and pathologic manifestations of SIV infections in rhesus monkeys are described.
Letvin
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NL
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772.
King
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NW
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology