Involvement of capsaicin-sensitive nerves of the rat urinary bladder in acrylamide neuropathy.
Acrylamide monomer is neurotoxic in man and experimental animals, producing a sensorimotor distal axonopathy. In spite of remarkable effect of acrylamide on micturition, resulting in urine retention in both man and rat, bladder autonomic innervation has been little studied. This study focused on the effect of acrylamide on capsaicin-sensitive nerves of the rat bladder, because of the role played by these fibres in regulating the afferent arm of reflex micturition.
Pharmacology Department, Menarini Ricerche Sud, Pomezia, Roma, Italy.
L
L
Abelli
G L
GL
Ferri
M
M
Astolfi
B
B
Conte
M
M
Parlani
V
V
Somma
P
P
Geppetti
D
D
Dahl
J M
JM
Polak
C A
CA
Maggi
D020106:Acrylamide; D000178:Acrylamides; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D002211:Capsaicin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*
D000178:Acrylamides; D020106:Acrylamide; D002211:Capsaicin