Intraneuronal laminin-like immunoreactivity in the human central nervous system.
Because laminin possesses potent neurotrophic activity, laminin-like immunoreactivity was investigated in formalin-fixed human brains, using affinity-purified anti-human placental laminin rabbit serum. Distinct laminin-like immunoreactivity was observed in neuronal soma of certain nuclear groups, and a 180-kDa band was noted in an immunoblot study of the supernatant of brain homogenate. These observations imply that many but not all central neurons have laminin-like immunoreactive molecules. Their functional role, however, remains to be clarified.
Department of Neurological Sciences, Tohoku University School of Medicine, Japan.
H
H
Suzuki
T
T
Yamamoto
H
H
Yamamoto
H
H
Konno
Y
Y
Iwasaki
Y
Y
Ohara
H
H
Terunuma
D001344:Autopsy; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D006801:Humans; D007797:Laminin / Q000032:analysis*; D009474:Neurons / Q000737:chemistry* / Q000166:cytology; D009928:Organ Specificity; D013116:Spinal Cord / Q000737:chemistry* / Q000473:pathology
D007797:Laminin