The role of chromosome abnormalities in reproductive failure.
The frequency of chromosome abnormalities in spontaneous abortions, stillbirths, livebirths and among all clinically recognized pregnancies is given. Data on the parental origin of sex chromosome abnormalities and certain autosomal trisomies determined using molecular probes are presented and the proportion of sperm and eggs that are nullisomic or disomic for a sex chromosome to an autosome 16, 18 or 21 is calculated.
Wessex Regional Cytogenetics Unit, General Hospital, Salisbury, Wiltshire, UK.
P A
PA
Jacobs
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D002869:Chromosome Aberrations / Q000453:epidemiology* / Q000235:genetics; D025063:Chromosome Disorders; D004247:DNA / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D014943:Global Health; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010063:Ovum; D011247:Pregnancy; D012729:Sex Chromosome Aberrations / Q000453:epidemiology; D013094:Spermatozoa
D004247:DNA