Pleural pressure changes in dogs measured from suprasternal fossa movements.
Movements of the suprasternal fossa during spontaneous breathing monitored with the surface inductive plethysmograph (SIP) have been shown to reflect changes of intrapleural pressure in conscious humans. Calibration of this device in anesthetized intubated dogs was accomplished by adjusting the electrical gain of its analog waveform to be equivalent to changes of airway pressure during inspiratory efforts against an occluded airway. This procedure, denoted the occlusion test, was also used to identify the site of esophageal balloon catheter placement for its recording of intrapleural pressure deflections. The validity of SIP-derived estimates of inspiratory and expiratory pulmonary resistances and lung compliance was established by finding close agreement with measurements obtained with intraesophageal pressure changes during 1) unimpeded spontaneous breathing, 2) inspiratory resistive loading, 3) bronchoprovocation with aerosolized carbachol, 4) mechanical ventilatory modalities, and 5) induced pulmonary edema. Therefore, movements of the suprasternal fossa with respiration can be reliably transformed into quantitative or semiquantitative changes of intrapleural pressure in anesthetized intubated dogs during major alterations of pulmonary mechanics.
Sackner
M A
MA
Division of Pulmonary Disease, University of Miami School of Medicine, Florida.
Grenvik
S
S
Moavero
N E
NE
Belsito
A
A
Chapman
G
G
Yerger
L
L
Krieger
B P
BP
D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001985:Bronchial Provocation Tests; D002217:Carbachol / Q000494:pharmacology; D004285:Dogs; D007384:Intermittent Positive-Pressure Breathing; D008170:Lung Compliance / Q000502:physiology; D009068:Movement; D010991:Plethysmography; D010994:Pleura / Q000502:physiology*; D011175:Positive-Pressure Respiration; D011312:Pressure; D011654:Pulmonary Edema / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology*; D013314:Stress, Mechanical
D002217:Carbachol