Ultrastructural evidence for serotonin-immunoreactive terminals contacting phrenic motoneurons in the cat.
The innervation of the phrenic motor nucleus in the cat by serotonin-containing neurons has been studied using retrograde tracing combined with immunohistochemistry at the electron microscope level. It was found that phrenic motoneuron cell bodies and dendrites are contacted by serotonin-immunoreactive synaptic terminals. This finding suggests that the activity of phrenic motoneurons is directly affected by serotonergic neurons.
Holtman
J R
JR
Department of Pharmacology, College of Medicine, University of Kentucky, Lexington 40536.
Vascik
D S
DS
Maley
B E
BE
D000818:Animals; D002415:Cats; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000502:physiology / Q000648:ultrastructure*; D009411:Nerve Endings / Q000378:metabolism / Q000648:ultrastructure*; D009434:Neural Pathways / Q000502:physiology; D010791:Phrenic Nerve / Q000502:physiology / Q000648:ultrastructure*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin