Studies on the determination and degradation of pyrimethamine in mammals.
Treatment of pyrimethamine with blood plasma in vitro yields a metabolite which is also produced when the drug is administered through intravenous injection in the rat. A thin layer liquid chromatographic method for quantitative and qualitative determination of pyrimethamine and its metabolite in plasma and biological tissues is described.
Department of Biosciences and Biotechnology, University of Roorkee, India.
R
R
Kumar
P
P
Kaushik
C B
CB
Sharma
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D008297:Male; D011739:Pyrimethamine / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D051381:Rats
D011739:Pyrimethamine