Micro in vitro assessment of Plasmodium falciparum sensitivity to chloroquine and mefloquine in Gujarat.
Micro in vitro tests conducted in 1987 in Surat district of Gujarat on sensitivity status of P. falciparum to chloroquine and mefloquine revealed that the parasite has developed resistance to chloroquine upto 32 pmol. The ED 99 in Hazira, Gothan and Umra areas of the district was found to be 17.3, 18.5 and 8.7 pmol/well for chloroquine and for mefloquine it was 14.5, 4.8 and 6.8 pmol/well respectively. Monitoring of P. falciparum resistance is indicated under National Malaria Eradication Programme.
Regional Office of Health and Family Welfare Ahmedabad, India.
P
P
Karmakar
S C
SC
Dutt
M V
MV
Narasimham
R C
RC
Sharma
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D007194:India; D015767:Mefloquine / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
D002738:Chloroquine; D015767:Mefloquine