Behaviour of lymphocyte subsets in response to immunotherapy with Propionibacterium avidum KP-40 in cancer patients.
In 15 patients the influence of unspecific immunostimulation/immunomodulation was studied. Patients constituting the therapeutical group suffered from colorectal- and gastric carcinoma, respectively, and were preoperatively treated with 10 mg whole cell preparation of immunomodulating Propionibacterium avidum KP-40. This adjuvant immunotherapy resulted in a significant increase (p less than 0.01) of the natural killer (NK)-cell population, however, total leukocyte and lymphocyte count as well as helper- and suppressor T-lymphocyte subsets did not significantly differ form control values.
Institut für Medizinische Mikrobiologie und Hygiene, Universität Köln.
J
J
Beuth
H L
HL
Ko
K M
KM
Peters
B
B
Bornhofen
G
G
Pulverer
D000276:Adjuvants, Immunologic; D015179:Colorectal Neoplasms / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D007958:Leukocyte Count; D016131:Lymphocyte Subsets; D008214:Lymphocytes / Q000276:immunology*; D011424:Propionibacterium / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic