Expression and distribution of Ia antigen in the murine small intestine. Influence of environment and cholera toxin.
Density and distribution of Ia antigen in the small intestine of C57bl/6 mice showed substantial differences, depending on the environment in which they were reared and maintained. Isolator-reared mice expressed low levels of epithelial Ia antigen in comparison to mice reared in a conventional environment. Oral administration of 10 micrograms of cholera toxin had no effect on the level of epithelial Ia expression. We conclude, therefore, that the mechanism whereby cholera toxin is able to potentiate mucosal responses to fed antigens is not related to changes in the level of epithelial Ia expression.
Department of Veterinary Medicine, University of Bristol, UK.
A D
AD
Wilson
P W
PW
Bland
C R
CR
Stokes
D000818:Animals; D000911:Antibodies, Monoclonal; D002772:Cholera Toxin / Q000378:metabolism / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis* / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012931:Social Environment
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D002772:Cholera Toxin