Choice of antibiotics, pharmacokinetics, and dose adjustments in acute and chronic renal failure.
A multitude of antimicrobial agents have become available over the past two decades. Appropriate use of these drugs demands not only an understanding of the antimicrobial spectrum of the agent but of the necessary dose adjustments because of renal or hepatic impairment. The use of computer-assisted pharmacokinetic modeling for dosing potentially toxic drugs such as aminoglycosides and vancomycin should be utilized whenever possible.
Wright State University School of Medicine, Dayton, Ohio.
J M
JM
Bernstein
S D
SD
Erk
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D009164:Mycobacterium Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents