[Action of low-dose estrogen and progestogen on the relief of climacteric symptoms and excretion of urinary calcium].
The effects of low-dose estrogen and progestogen on menopausal symptoms and urinary excretion of calcium were studied with Kuppermen score and fasting morning urine Calcium/Creatinine (Ca/Cr) ratio, respectively, in 69 perimenopausal women. The women were divided into 3 groups: amenorrhea less than 1 year (14 women); post menopause 1 approximately 3 years (19); and post menopause more than 3 years (36). Fasting urine Ca/Cr ratio in the postmenopausal group 1 approximately 3 years was 0.19 +/- 0.01, significantly higher than that (0.14 +/- 0.01) in the amenorrhea group less than 1 year and (0.11 +/- 0.006) the postmenopausal group more than 3 years. 18 women received sequentially 4 patterns of low-dose oral estrogen and progestogen: MPA 2 mg Q O D., EE 5 micrograms Q D, EE 5 micrograms Q O D, and EE 5 micrograms and MPA 2 mg Q O D alternately. Each pattern was used for 3 weeks and discontinued for an interval of two 2 weeks, then started the next pattern and so on EE 5 micrograms and MPA 2 mg Q O D alternately gave the best results both in improving symptoms and lowering urine Ca/Cr ratio. Seven women having intermittent large dose EE 50 micrograms every 10 days or Premarin 2.5 mg every 7 days had symptoms relieved but inconsistent decrease of urine Ca/Cr ratio.
Union Medical College Hospital.
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Lin
D002118:Calcium / Q000652:urine*; D002979:Climacteric; D003404:Creatinine / Q000652:urine; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008593:Menopause; D011372:Progestins / Q000008:administration & dosage*
D004967:Estrogens; D011372:Progestins; D003404:Creatinine; D002118:Calcium