Capillary zone electrophoresis in pharmaceutical analysis.
The paper presents a brief characterization of capillary zone electrophoresis, a modern analytical separation method with high expediency for practical applications, especially in pharmaceutical analysis. Basic theoretical considerations are presented and discussed to explain the effects of the operational parameters upon the separation efficiency and resolution of species. Descriptions of simple instrumentation and of the analytical procedure itself are given. Experimental examples are given of the separation of mixtures of pharmaceutically important compounds and of the effects of operational parameters, especially pH of BGE and voltage applied. Lastly, the practical application of CZE for analysis of isoxsuprine in commercial preparations is shown.
Istituto di Cromatografia, C.N.R., Roma, Italy.
S
S
Fanali
M
M
Cristalli
A
A
Nardi
L
L
Ossicini
S K
SK
Shukla
D004586:Electrophoresis / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations