[Right ventricular function and effort tolerance in patients with chronic congestive heart insufficiency. A cross-over double-blind study].
We tried to assess the value of both ventricular function changes and its correlation with maximal exercise capacity in patients with chronic heart failure. For this purpose, a double blind crossover study was designed, and the change in the exercise tolerance and both ventricular ejection fraction were evaluated. When compared with digoxin treatment (p less than 0.01) and with a control-period (p less than 0.001), the captopril increases total exercise time significantly. The response of right ventricular ejection fraction was similar. The changes in right ventricular ejection fraction, but not those of left ventricular ejection fraction, correlated with the variations of exercise time (r = 0.67). These facts suggest that right ventricular function is an important determinant of exercise capacity in patients with chronic heart failure and that its behaviour explain, in part, the response to captopril treatment.
Servicio de Cardiología, Hospital Civil de Bilbao, Vitoria.
P M
PM
Montes Orbe
J M
JM
Ormaetxe
J D
JD
Martínez
E
E
Rodríguez
E
E
Ruiz de Azúa
M M
MM
Iriarte
D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D002908:Chronic Disease; D004077:Digoxin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013318:Stroke Volume / Q000187:drug effects*; D013997:Time Factors
D004077:Digoxin; D002216:Captopril
Función ventricular derecha y tolerancia al esfuerzo en los pacientes con insuficiencia cardíaca congestiva crónica. Estudio cruzado a doble ciego.