Biokinetics of 237Pu citrate and nitrate in the rat: implications for Pu studies in man.
Plutonium-237 decays mainly by electron capture with a half-life of 45 d. Alpha particles are emitted in only 5 x 10(-3)% of its disintegrations. This nuclide can now be produced with relatively small amounts of alpha-emitting contaminants so that, in principle, 237Pu can be used for studies of Pu biokinetics in man. However, because of its high specific activity, there was some doubt that its metabolism would be the same as that of the alpha- and beta-emitting isotopes of Pu normally encountered in the nuclear industry. In this study, the biokinetics of nearly "pure," high specific activity 237Pu are compared with those of lower specific activity, "impure" 237Pu containing significant amounts of alpha-emitting Pu, following administration to rats by intravenous injection as the citrate. Both the distribution and excretion of the "pure" and "impure" 237Pu used in the two studies were similar and also in good agreement with the results of previously reported studies using 239Pu and 241Pu citrate, thus validating the use of 237Pu for studies of Pu metabolism in man. Data on the biokinetics of 237Pu nitrate are also included.
Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxfordshire, United Kingdom.
R J
RJ
Talbot
D A
DA
Knight
A
A
Morgan
D000818:Animals; D002951:Citrates / Q000493:pharmacokinetics*; D008297:Male; D009566:Nitrates; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D011005:Plutonium / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D002951:Citrates; D009566:Nitrates; D009942:Organometallic Compounds; C015459:plutonium nitrate; D011005:Plutonium