Is acidosis the clue to the loss of structure and functioning of the sarcolemma?
The only way for a tissue or organ to survive ischemia is by reperfusion or restoration of the blood flow. However, if the ischemic period is too long reperfusion leads to a Ca2+ overload of the myocardial cells and thereby to cell death. The question is; what are the key events during ischemia which cause this transition from reversible to irreversible injury. In this article we discuss whether acidosis may play a crucial role by inducing Ca2+ release from the sarcolemma and reorganization of membrane components especially the membrane lipids, i.e. lateral phase separation, resulting in membrane protein clustering and changes in lipid asymmetry.
Department of Molecular Cell Biology, University of Utrecht, NL.
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Verkleij
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JA
Post
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Schneijdenberg
D000138:Acidosis / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D012508:Sarcolemma / Q000502:physiology* / Q000648:ultrastructure