Relative efficiency of therapeutic donor insemination using a luteinizing hormone monitor.
A prospective randomized study was performed to evaluate the use of a urinary luteinizing hormone (LH) detection kit with 1 insemination as compared with 2 alternate day inseminations with timing based on previous cycle length and basal body temperature changes. The study involved 60 patients who underwent a total of 264 therapeutic donor insemination cycles using cryopreserved semen specimens. Patients alternated LH-kit timed cycles with cycles timed by non-LH methods for a total of 6 cycles or until pregnancy was achieved. Fecundability rates were 12.3% for LH-kit cycles and 5.3% for non-LH method cycles. The difference in outcome was not statistically significant. However, when the LH kit plus 1 insemination was compared with 2 inseminations timed by conventional methods, there appeared to be a distinct monetary and time expenditure advantage. These findings suggest that sufficient advantage may be derived from use of an LH kit to recommend its use on a routine basis for the timing of therapeutic donor insemination.
Federman
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CA
Department of Obstetrics and Gynecology, University of Wisconsin, Madison 53792.
Dumesic
D A
DA
Boone
W R
WR
Shapiro
S S
SS
D000328:Adult; D002985:Clinical Protocols / Q000592:standards; D005260:Female; D005298:Fertility / Q000502:physiology; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D007986:Luteinizing Hormone / Q000652:urine*; D008597:Menstrual Cycle / Q000502:physiology / Q000652:urine*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014021:Tissue Preservation
D007986:Luteinizing Hormone