Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults.
The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men. Only trazodone significantly increased deep sleep without otherwise altering the normal architecture of sleep. The alpha-adrenergic receptor-blocking property of trazodone and a relative lack of noradrenergic reuptake blocking and the lack of anticholinergic effects are hypothesized to be responsible for the effects on sleep.
Ware
J C
JC
Sleep Disorders Center, Sentara Norfolk General Hospital, VA 23507.
Pittard
J T
JT
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005712:Galvanic Skin Response / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D012895:Sleep, REM / Q000187:drug effects; D014196:Trazodone / Q000494:pharmacology* / Q000627:therapeutic use; D014299:Trimipramine / Q000494:pharmacology
D010919:Placebos; D014299:Trimipramine; D014196:Trazodone