Pyroglutamic acid improves the age associated memory impairment.
Pyroglutamic acid (PCA) was compared with placebo in a randomized, double blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with PCA and 20 with placebo over a period of 60 d. Memory functions were evaluated at baseline and after 60 d of treatment by means of a battery made up of 6 memory tasks. The results suggest that PCA is effective in improving some verbal memory functions in subjects affected by age-related memory decline.
Cattedra di Patologia Neurologica II dell'Università di Catania, Italy.
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S
Grioli
C
C
Lomeo
M C
MC
Quattropani
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G
Spignoli
C
C
Villardita
D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005556:Form Perception / Q000187:drug effects; D006801:Humans; D008569:Memory Disorders / Q000188:drug therapy* / Q000523:psychology; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011761:Pyrrolidonecarboxylic Acid / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D011760:Pyrrolidinones; D011761:Pyrrolidonecarboxylic Acid