Psychological development of children who were treated antenatally with corticosteroids to prevent respiratory distress syndrome.
Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. Aspects of the children's intellectual and motor development, school achievement, and social-emotional functioning were investigated. There were no differences between the corticoid group and the placebo group on these variables, nor were there more children with learning difficulties and behavioral disturbances in either of the groups.
Department of Neonatology, Academic Medical Centre, Amsterdam, The Netherlands.
B
B
Schmand
J
J
Neuvel
H
H
Smolders-de Haas
J
J
Hoeks
P E
PE
Treffers
J G
JG
Koppe
D001623:Betamethasone / Q000009:adverse effects*; D002648:Child; D002657:Child Development / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D010919:Placebos; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011581:Psychological Tests; D002666:Psychology, Child; D016032:Randomized Controlled Trials as Topic; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*
D010919:Placebos; D001623:Betamethasone