[Tissue specificity of monoclonal antibodies to cells of human pulmonary adenocarcinoma].
Immunohistological localization of antigens revealed by 5 MoAbs to human lung adenocarcinoma cell line was studied by indirect immunoperoxidase technique. One of the MoAbs--A2F4--showed a relative specificity to epithelial tissues having a glandular differentiation. Except approximately 50% of normal cells of lungs and those of pulmonary tumours (mostly adenocarcinomas) they reacted with some other normal (stomach, oesophagus, breast) and tumoral (gastric, mammary and colonic) tissue cells. Other four MoAbs reacted with the much larger number of cells including some nonepithelial (granulocytes and histiocytes) ones.
Kokhanova
I D
ID
Egorova
S G
SG
Vial'tsev
N V
NV
Pugachev
K K
KK
Avdeev
G I
GI
D000230:Adenocarcinoma / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001940:Breast / Q000166:cytology / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D004938:Esophageal Neoplasms / Q000473:pathology; D004947:Esophagus / Q000166:cytology / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000473:pathology*; D013270:Stomach / Q000166:cytology / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal
Izuchenie tkanespetsifichnosti monoklonal'nykh antitel k kletkam adenokartsinomy legkogo cheloveka.