[Inflammatory reaction and laboratory tests: interleukin-1].
Recent progress on the study of IL 1 is summarized and depicted, particularly emphasizing the variety of IL 1 function, and the role of other cytokine inducers. While it has been established that IL 1 has a variety of biological functions in vitro and in vivo, some of these functions are not a direct action of IL 1, but may be ascribed to some other cytokines induced by IL 1, since IL 1 can induce IL 6 (as an inducer of acute phase protein), IL 8 (as a neutrophil chemotactic factor), or IL 1 itself. Other important functions of IL 1 in vivo including resistance to bacterial infection, radioresistance and anti-tumor activity are of great interest to determine whether its action is direct or indirect through the induction of other factors, although the importance of IL 1 yet remains. Finally, the bioassay and ELISA assay of IL 1 alpha and IL 1 beta were established. The IL 1 level in serum, amniotic fluids, and synovial fluids from rheumatoid arthritis have been determined and its biological significance has been discussed.
Kasahara
T
T
Department of Medical Biology and Parasitology, Jichi Medical School, Tochigi pref.
Akaboshi
T
T
Tsunoda
H
H
Onozaki
K
K
Yamagishi
Y
Y
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D007375:Interleukin-1 / Q000032:analysis* / Q000502:physiology
D007375:Interleukin-1