The synthesis and antilipidperoxidation activity of 4,4-diarylbutylamines and 4,4-diarylbutanamides.
A series of 4,4-diarylbutylamine and 4,4-diarylbutanamide derivatives has been synthesized and evaluated for their antilipidperoxidation (ALP) activity and acute toxicity (LD50). Some of them were found to have significant ALP activity.
Miyano
S
S
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Tatsuoka
T
T
Suzuki
K
K
Imao
K
K
Satoh
F
F
Ishihara
T
T
Hirotsu
I
I
Kihara
T
T
Hatta
M
M
Horikawa
Y
Y
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001923:Brain Chemistry / Q000187:drug effects; D002082:Butylamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000577:Amides; D001555:Benzene Derivatives; D002082:Butylamines