[Immunization against human malaria: present knowledge].
The authors review different aspects of immunization against malaria according to the different stages of the parasitic cycle of Plasmodium falciparum: sporozoite vaccine preventing organism infestation, merozoïte vaccine and gametocyte vaccines preventing the accomplishment of the sexual cycle. Progress of molecular biology and better knowledge of cellular immunity provide some prospects regarding parasitic vaccinology, thanks to genetic engineering. Recombinant vaccines in vitro, in vivo and synthetized are under study and provide the best prospects regarding immunization against human malaria.
Peyron
F
F
Laboratoire de Parasitologie et de Pathologie exotique, C.N.R.S. U.R.A. 1344, Centre collaborateur de l'Organisation Mondiale de la Santé, Faculté de Médecine, Université Joseph Fourier, La Tronche.
Oury
B
B
Ambroise-Thomas
D000818:Animals; D005818:Genetic Engineering; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007114:Immunization / Q000379:methods / Q000639:trends*; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000254:growth & development; D014614:Vaccines, Synthetic / Q000627:therapeutic use
D014614:Vaccines, Synthetic
La vaccination antipaludique, où en est-on?