The carboxy terminus of human immunodeficiency virus type 1 gp160 limits its proteolytic processing and transport in transfected cell lines.
Mutagenesis of the transmembrane domain and cytoplasmic tail of human immunodeficiency virus type 1 envelope glycoprotein gp160 revealed that its intracellular transport and processing in transfected cell lines were modulated by a functional domain included in the carboxy-terminal sequence consisting of residues 751 to 856.
Department of Developmental Biology, Genetech Inc., South San Francisco, California 94080.
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Haffar
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Nakamura
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Berman
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002678:Chimera; D004591:Electrophoresis, Polyacrylamide Gel; D015686:Gene Products, env / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D006023:Glycoproteins / Q000235:genetics; D006026:Glycoside Hydrolases; D019302:HIV Envelope Protein gp160; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009154:Mutation; D011498:Protein Precursors / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014162:Transfection; D014759:Viral Envelope Proteins / Q000302:isolation & purification
D015686:Gene Products, env; D006023:Glycoproteins; D019302:HIV Envelope Protein gp160; D011498:Protein Precursors; D014759:Viral Envelope Proteins; D006026:Glycoside Hydrolases