Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy.
Continuous-wave Doppler ultrasound was used to assess blood flow velocities and determine the pulsatility index of the uterine arteries in ten pregnant women at 23-33 weeks' gestation during indomethacin therapy for preterm labor or polyhydramnios. There was no statistically significant difference in the pulsatility index of the uterine arteries during maternal indomethacin treatment (mean +/- SD 0.85 +/- 0.29) compared with pre-treatment values (0.85 +/- 0.23). Although studies in animals have reported that indomethacin increases uterine impedance to flow, it appears that it does not affect the uterine impedance in humans.
Mari
G
G
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Kirshon
B
B
Wasserstrum
N
N
Moise
K J
KJ
Deter
R L
RL
D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D006831:Polyhydramnios / Q000188:drug therapy; D011247:Pregnancy; D011673:Pulsatile Flow / Q000187:drug effects; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply*
D007213:Indomethacin