Antibiotic prophylaxis in proximal femoral fracture.
A prospective randomized double-blind trial was carried out to assess the effectiveness of one dose of prophylactic cefuroxime versus placebo in 502 patients who underwent surgery for a proximal femoral fracture. With an overall deep infection rate of 2.2 per cent there was no significant difference in the superficial or deep wound infection rate between the two groups. However, there was a significant reduction in the incidence of postoperative bacteriuria in the cefuroxime group. A study of three doses of cefuroxime versus placebo is now proposed.
University Department of Orthopaedic Surgery, Princess Margaret Rose Orthopaedic Hospital, Edinburgh, UK.
M M
MM
McQueen
M A
MA
LittleJohn
R S
RS
Miles
S P
SP
Hughes
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001437:Bacteriuria / Q000517:prevention & control; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005265:Femoral Neck Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
D002511:Cephalosporins; D002444:Cefuroxime