The mouse model of oxygen-induced retinopathy: a suitable animal model for angiogenesis research.
Newborn mice exposed to high (greater than 98%) ambient oxygen during the newborn period and subsequently removed to room air will develop a proliferative retinopathy which mimics the neovascular component of acute retinopathy of prematurity. In this paper, we report preliminary ultrastructural findings on the vitreous new vessels in the mouse model of oxygen-induced retinopathy, and argue that the model is appropriate for research on non surgical treatments for ROP in particular and angiogenesis in general.
Gole
G A
GA
Department of Ophthalmology, Flinders University of South Australia, Adelaide.
Browning
J
J
Elts
S M
SM
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005123:Eye / Q000098:blood supply / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D010100:Oxygen / Q000009:adverse effects*; D015861:Retinal Neovascularization; D012178:Retinopathy of Prematurity / Q000209:etiology*
D010100:Oxygen