Acute lymphoblastic leukemia in an XYY male.
A case of acute lymphoblastic leukemia (ALL) in a 16-year-old male with a 47,XYY karyotype is reported. This chromosome aneuploidy was found in both bone marrow (BM) cells and mitogen-stimulated lymphocytes. Immunologic profile of leukemic cells showed a null phenotype. To our knowledge, this is the fifth case reported in the literature.
Department of Hematology, Hospital Ramon y Cajal, Madrid, Spain.
J
J
Perez de Oteyza
A
A
Sureda
T
T
Ferro
J G
JG
Laraña
J
J
Odriozola
L
L
Escribano
J L
JL
Navarro
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014997:XYY Karyotype
D015703:Antigens, CD