Activity and distribution of learning-related neurons in monkey (Macaca fuscata) prefrontal cortex.
The involvement of monkey (Macaca fuscata) prefrontal cortex (PFC) neurons in motor output decisions was studied by recording single neuron activity during 3 tasks: (a) go-left, go-right, or no-go decisions, (b) operant bar press feeding based on discrimination of food and nonfood, and (c) either delayed matching-to-sample (DMS) or DMS with response delay. Combinations of single neuron responses during the 3 tasks suggested 7 types of PFC neurons that were related to attention, choice, task-unique memory, reward anticipation, laterality, initiation of movement, and suppression of movement. The authors suggest that responses of PFC neurons do not depend on physical properties of the stimuli, but on their behavioral significance. PFC neurons might be important for appropriate behavior in response to external stimuli and internal or motivational factors.
Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Japan.
K
K
Yamatani
T
T
Ono
H
H
Nishijo
A
A
Takaku
D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D001245:Association Learning / Q000502:physiology; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology; D003463:Cues; D004193:Discrimination Learning / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D008251:Macaca; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009042:Motivation; D009474:Neurons / Q000502:physiology; D009949:Orientation / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D010897:Pitch Discrimination / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*