Translocation t(3;22)(q23;q11) in three patients with diffuse large B cell lymphoma.
In our series of 134 patients with a diagnosis of non-Hodgkin's lymphoma (NHL) and clonal chromosomal abnormalities, three were found to show an identical t(3;22)(q28;q11) translocation. All were old patients with isolated lymphadenomegaly and diffuse large noncleaved cell lymphoma. All expressed a B cell immunophenotype, and all entered a complete remission when treated with aggressive chemotherapy. This translocation could, therefore, delineate a particular subtype of diffuse large cell NHL.
Department of Genetics, University Hospital, Grenoble, France.
D
D
Leroux
M
M
Stul
J J
JJ
Sotto
C
C
Bastard
P
P
Couderc
J C
JC
Bensa
M
M
Monteil
J J
JJ
Cassiman
P
P
Jalbert
D000368:Aged; D001402:B-Lymphocytes; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007621:Karyotyping; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic