Management of nonstaphylococcal toxic epidermal necrolysis: follow-up study of 16 case histories.
In this study the clinical and laboratory data of 14 patients who experienced 16 attacks of nonstaphylococcal toxic epidermal necrolysis (TEN) are presented. All patients were treated in the Department of Dermatology of the University Hospital of Utrecht. Only 1 patient died. Attention is focused on a successful management consisting of reversed barrier nursing, painstakingly executed skin care, timely use of antibiotics and a therapy consisting of high dosages of corticosteroids. Thorough management in centers experienced in the treatment of TEN is essential for good treatment results. Further investigations concerning the use of corticosteroids in treating TEN are needed.
Department of Dermatology, Zeister Algemeen Ziekenhuis, The Netherlands.
M J
MJ
Tegelberg-Stassen
W A
WA
van Vloten
H
H
Baart de la Faille
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010328:Patch Tests; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000401:mortality / Q000628:therapy*
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents