Development of assisted conception.
Advances in assisted human conception in the last twenty years were founded on the detailed knowledge of the mammalian reproductive cycle gained in the earlier years of this century. Several lines of study coincided in the 1960's, including the use of ovarian stimulants to regulate follicle growth, oocyte maturation and ovulation, fertilization and embryonic growth in vitro, and the introduction of safer and better methods of laparoscopy. A combination of these techniques with embryo replacements in the uterus permitted the introduction of IVF for the alleviation of infertility. In turn, these methods were extended to other forms of assisted conception, including GIFT, which gave a wider choice of methods for the treatment of specific causes of infertility. Advances during the last decade include rapid progress in the use of ultrasound, the introduction of the LHRH agonists in new forms of stimulation, embryo cryopreservation, and micromanipulative techniques on oocytes and embryos for the alleviation of male infertility and the diagnosis of genetic disease in preimplantation embryos.
Edwards
R G
RG
Physiological Laboratory, University of Cambridge, UK.
Craft
I
I
D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D012099:Reproductive Techniques / Q000639:trends*
D005300:Fertility Agents, Female