[Relation of the anti-anginal effect and blood serum level of verapamil in patients with exercise-induced stenocardia].
In 9 patients with stable angina pectoris of effort the authors studied the relation between the effect of verapamil in single and regular administration and concentration of invariable preparation and its primary metabolites in the blood serum. Antiischemic effect of verapamil was assessed with use of repeated identical and individual loads on treadmill in combination with ECG monitoring before and at the end of treatment. Linear correlation was established between the effect and concentration of verapamil in the blood serum under the conditions of single and regular administration. In long-term use of verapamil the authors noted a significant increase in the action of a single dose caused by verapamil cumulation in the blood serum. During long-term treatment by verapamil a marked effect was recorded in significantly more high concentrations of the preparation in the blood as compared to a single administration. The main primary metabolites of verapamil failed to affect on antianginal effect both in single and regular administration.
Slastnikova
I D
ID
Rumiantsev
D O
DO
Piotrovskiĭ
V K
VK
Metelitsa
V I
VI
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D014700:Verapamil
Sviaz' antianginal'nogo éffekta i kontsentratsii verapamila v syvorotke krovi u bol'nykh so stenokardieĭ napriazheniia.