Ischemic stroke due to protein C deficiency.
Plasma protein C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis has been only rarely observed. We describe a young patient with heterozygous protein C deficiency who experienced a severe stroke due to thrombotic occlusion of the left middle cerebral artery.
Kohler
J
J
Department of Neurology, University of Freiburg, Federal Republic of Germany.
Kasper
J
J
Witt
I
I
von Reutern
G M
GM
D000328:Adult; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D010375:Pedigree; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D012307:Risk Factors; D014463:Ultrasonography
D011486:Protein C