Stimulation of p21ras upon T-cell activation.
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
Downward
J
J
Signal Transduction Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Graves
J D
JD
Warne
P H
PH
Rayter
S
S
Cantrell
D A
DA
D020690:GTPase-Activating Proteins; D011905:Genes, ras; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008213:Lymphocyte Activation; D015689:Oncogene Protein p21(ras) / Q000235:genetics* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; D020703:ras GTPase-Activating Proteins; D011493:Protein Kinase C; D015689:Oncogene Protein p21(ras)