[Antibiotic prophylaxis with sulbactam/ampicillin in colon surgery].
We evaluated the effectiveness of sulbactam/ampicillin (S/A) as a perioperative prophylaxis regimen in elective colic surgery (procedures lasting less than 4 hours). We studied 18 patients (11 males, 7 females; mean age 46 yrs, range 21-72), by an open, non-comparative trial: S/A was given soon before anesthesia (1 g + 2 g) and the same dose was repeated every 6 hours, up to 5 doses. The drug was well tolerated, and there were no side effects requiring the interruption of the prophylaxis. Infection rate was low (only one case of evident suppuration of the wound).
Università Cattolica del Sacro Cuore, Roma Instituto di Clinica Chirurgica.
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D
Gui
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G
Anastasio
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M
Pescatori
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P
Ronconi
D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003082:Colectomy; D003106:Colon / Q000601:surgery*; D003125:Colostomy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013407:Sulbactam / Q000008:administration & dosage*
D000667:Ampicillin; D013407:Sulbactam
Profilassi antibiotica con sulbactam/ampicillina in chirurgia colica.