Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever.
We undertook a randomized clinical trial comparing therapeutic efficacy of the 1-day doxycycline regimen with the 5-day josamycin regimen for Mediterranean spotted fever. All 59 patients recovered uneventfully, and results did not significantly differ between the two schedules. One-day doxycycline therapy is an effective, easy, and inexpensive treatment. Josamycin is a useful therapeutic alternative that may be particularly convenient for pregnant women and patients with a history of allergy to tetracyclines.
Department of Internal Medicine, Hospital de Terrassa, Spain.
F
F
Bella
B
B
Font
S
S
Uriz
T
T
Muñoz
E
E
Espejo
J
J
Traveria
J A
JA
Serrano
F
F
Segura
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015570:Josamycin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012282:Rickettsia Infections / Q000188:drug therapy*
D015570:Josamycin; D004318:Doxycycline