The multifactorial role of ATP in repair processes and radioprotection.
Endogenous ATP as a source of energy appears to play an important role associated with repair processes after ionising radiation damage in living organisms. Also exogenous ATP can play a central part in radioprotection. This paper considers interaction between the multifactorial roles of ATP in radioprotection and metabolic provision for repair processes, which can depend on its physiological regulatory function as a neuromodulator via cell membrane receptors. It is hypothesised that all these complex functions reflect an adaptive defence mechanism, against radiation insults, in which ATP plays a pivotal role to maintain homeostasis.
Research Institute for Medical Biophysics, S A Medical Research Council, Tygerberg.
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Szeinfeld
D000255:Adenosine Triphosphate / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D002477:Cells / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004734:Energy Metabolism; D008954:Models, Biological; D011837:Radiation-Protective Agents
D011837:Radiation-Protective Agents; D000255:Adenosine Triphosphate