Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization.
The novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, alpha-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system.
Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
J E
JE
Leet
D R
DR
Schroeder
B S
BS
Krishnan
J A
JA
Matson
D000596:Amino Acids / Q000032:analysis; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification*; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer; D003460:Crystallization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; C066106:himastatin