[Antibiotherapy in chronic familial granulomatosis].
Antibacterial therapy in chronic granulomatous disease requires antimicrobials active on Staphylococcus aureus and enterobacteria, which also have a good intracellular penetration and activity as rifampicin, fluoroquinolone, fosfomycin, cotrimoxazole. Several trials showed that cotrimoxazole was effective for the prevention of bacterial infection: thus, this antimicrobial can be used as long-term and continuous prophylaxia. Fungal infections require the use of amphotericin B. The place of new imidazole compounds as itraconazole should be assessed.
Vilde
J L
JL
Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Bichat-Claude-Bernard, Paris.
Leport
C
C
D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D004338:Drug Combinations / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000235:genetics*; D006801:Humans; D009181:Mycoses / Q000150:complications / Q000188:drug therapy; D011292:Premedication; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004338:Drug Combinations; D000666:Amphotericin B; D014295:Trimethoprim; D013420:Sulfamethoxazole
Antibiothérapie au cours de la granulomatose chronique familiale.