Skin substitutes in upper extremity burns.
Four techniques for permanent skin replacement with skin substitutes are described. A claim of superiority to conventional skin grafting on upper extremity and hand burns is not made, but some clinical observations and histologic evidence of different healing characteristics are shown. The composite grafts described appear to effectively replace the bilayered structure of skin and seem to have good subjective resistance to shear forces. If the skin replacement is durable and heals with less scarring than conventional skin grafts, the inexorable course to stiffness and contracture may be altered. Further basic science and clinical investigation may provide us with a better way of managing these difficult problems.
Harvard Medical School, Children's Hospital, Brigham and Women's Hospital, Boston, Massachusetts.
C A
CA
Hergrueter
N E
NE
O'Connor
D001458:Bandages; D001684:Biological Dressings; D002056:Burns / Q000628:therapy*; D002478:Cells, Cultured; D002648:Child; D003094:Collagen; D004847:Epithelial Cells; D004848:Epithelium / Q000637:transplantation; D005347:Fibroblasts / Q000166:cytology; D006025:Glycosaminoglycans; D006230:Hand Injuries / Q000628:therapy*; D006801:Humans; D008297:Male
D006025:Glycosaminoglycans; D003094:Collagen