[Radio-oncological treatment possibilities in local recurrence of rectal carcinoma. An interdisciplinary comparison].
Local recurrences of rectal carcinomas are frequently associated with a considerable morbidity and a dismal prognosis. Surgical resection leads to long term tumor control in about 30 to 40%, but surgery can be offered to only 10 to 30% of the patients. Cytotoxic chemotherapy is able to induce local responses in 15 to 40% of the cases--similar figures as achieved by radiation therapy alone. A pilot study is presented using radiation therapy combined with the sensitizing agent razoxane (ICRF 159). There was an objective response rate of 62% and the median survival rose to 24 months (13 months with radiation therapy alone). These data compare almost to results seen in surgical series. However, they need confirmation.
Rhomberg
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Abteilung für Radioonkologie, des Landeskrankenhauses Feldkirch.
Eiter
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D010879:Piperazines / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D011929:Razoxane / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis
D010879:Piperazines; D011838:Radiation-Sensitizing Agents; D011929:Razoxane
Radioonkologische Behandlungschancen beim Lokalrezidiv des Rektumkarzinoms. Ein interdisziplinärer Vergleich.