Silicone rubber-hydrogel composites as polymeric biomaterials. II. Hydrophilicity and permeability to water-soluble low-molecular-weight compounds.
The surface and transport properties of water-swollen silicone rubber-hydrogel composites were investigated. Surface wettability of these materials, composed of a polysiloxane matrix and the hydrogel phase consisting of very fine particles of lightly cross-linked poly(2-hydroxyethylmethacrylate), increased markedly with increasing content of the hydrogel phase. For composite materials containing a lightly cross-linked 2-hydroxyethylmethacrylate (HEMA)-methacrylic acid (MAA) copolymer and polymethacrylic acid (PMAA) as the hydrogel phase, permeability to water-soluble organic compounds and drugs were measured. The permeability varied within a broad range depending on the composition and content of the hydrogel phase. High permeation rates could be obtained while still retaining relatively fair mechanical properties. Relationships between the composition of silicone rubber-hydrogel composites, their structure and the permeation coefficients of the individual permeates are discussed.
Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague.
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Lopour
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Vondrácek
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Janatová
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Sulc
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Vacík
D001672:Biocompatible Materials / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003188:Composite Resins / Q000737:chemistry*; D008422:Materials Testing; D008970:Molecular Weight; D010539:Permeability; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012826:Silicone Elastomers; D013499:Surface Properties; D013718:Tensile Strength
D001672:Biocompatible Materials; D003188:Composite Resins; D011109:Polymethacrylic Acids; D012826:Silicone Elastomers; D011102:Polyhydroxyethyl Methacrylate