Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy.
Continuous-wave Doppler ultrasound was used to assess blood flow velocities and determine the pulsatility index of the uterine arteries in ten pregnant women at 23-33 weeks' gestation during indomethacin therapy for preterm labor or polyhydramnios. There was no statistically significant difference in the pulsatility index of the uterine arteries during maternal indomethacin treatment (mean +/- SD 0.85 +/- 0.29) compared with pre-treatment values (0.85 +/- 0.23). Although studies in animals have reported that indomethacin increases uterine impedance to flow, it appears that it does not affect the uterine impedance in humans.
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
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G
Mari
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Kirshon
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Wasserstrum
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Moise
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Deter
D001783:Blood Flow Velocity / Q000187:drug effects; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D006831:Polyhydramnios / Q000188:drug therapy; D011247:Pregnancy; D011673:Pulsatile Flow / Q000187:drug effects; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply*
D007213:Indomethacin