[Morphofunctional status of blood and bone marrow cells in acute experimental hepatitis induced by allyl alcohol].
Acute experimental hepatitis was induced by a single injection of 1% water solution of allyl spirit in a dose of 100 mg/kg. Morphofunctional state of peripheral blood and bone marrow cells was studied with the use of hematological and cytochemical methods. Specific changes were detected in the peripheral blood and bone marrow cell parameters in the early (6 and 12 h) and late (24h--10 days) periods after the injection. Changes in the liver and in the blood and bone marrow cells were irreversible. Most of the parameters studied returned to normal 22 days after the injection of allyl spirit.
M G
MG
Skorokhodova
E I
EI
Grishkevich
G V
GV
Karpova
T I
TI
Fomina
T V
TV
Vetoshkina
A S
AS
Saratikov
D000208:Acute Disease; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D004195:Disease Models, Animal; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006520:Hepatitis, Animal / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D008297:Male; D020005:Propanols; D051381:Rats; D011919:Rats, Inbred Strains
D020005:Propanols; C006463:allyl alcohol
Morfofunktsional'noe sostoianie kletok krovi i kostnogo mozga pri ostrom éksperimental'nom gepatite, vyzvannom allilovym spirtom.