Hypotensive effect of long-term levodopa in patients with Parkinson's disease.
To study the hypotensive effect of L-dopa in patients with Parkinson's disease on long-term L-dopa, the blood pressure (BP) was measured in 14 patients and 6 controls before 100 mg L-dopa plus decarboxylase inhibitor and for up to 180 min after dosing. Plasma monoamines and motor functions were assessed. The mean BP was reduced between 60 and 180 min after dosing in the patients, whereas such a reduction was not observed in 5 patients from whom L-dopa was withheld and in controls who showed a high ratio of plasma dopamine compared to plasma L-dopa after dosing. The L-dopa-induced reduction in BP was thought to be due to a central nervous mechanism.
Department of Neurology, Saitama Medical School, Japan.
S
S
Iwasaki
K
K
Hamaguchi
A
A
Iwasaki
M
M
Takakusagi
Y
Y
Narabayashi
D000368:Aged; D015306:Biogenic Monoamines / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002230:Carbidopa / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D011597:Psychomotor Performance / Q000187:drug effects
D015306:Biogenic Monoamines; D007980:Levodopa; D002230:Carbidopa