Efficacy of fluconazole in prophylaxis and treatment of experimental Candida endocarditis.
The efficacy of fluconazole, a bis-triazole antifungal agent, for prophylaxis and treatment of endocarditis due to Candida albicans and Candida parapsilosis is assessed in a rabbit model. Fourteen daily injections of fluconazole at doses of 20 and 10 mg/kg of body weight eradicated C. albicans and C. parapsilosis, respectively, from the cardiac vegetations in all animals tested. Amphotericin B (3 mg/kg) and flucytosine (35 mg/kg) both singly and in combination failed to achieve eradication in 100% of the animals. A two-dose prophylactic regimen of 30 mg of fluconazole/kg was consistently successful in preventing experimental endocarditis caused by C. albicans or C. parapsilosis.
Longman
L P
LP
School of Dental Surgery, University of Liverpool, United Kingdom.
Hibbert
S A
SA
Martin
M V
MV
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000517:prevention & control; D004696:Endocarditis / Q000188:drug therapy* / Q000517:prevention & control; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use*; D005437:Flucytosine / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D011817:Rabbits
D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine