[Hyposensitization in pollinosis. Results of a 3-year controlled study with 2 depot-allergoid grass pollen extracts: aluminum hydroxide-adsorbed allergoid and tyrosine-adsorbed allergoid].
For controlled hyposensitization treatment over a period of three years 36 patients with confirmed grass pollen sensitization had been selected in 1986 and randomly distributed to receive preseasonal injection therapy: 23 patients were treated with an average of seven AGD (aluminium-adsorbed allergoid) injections, and 13 patients had received six TA (tyrosine-adsorbed allergoid) injections. Evaluation of the trial data collected during three years of preseasonal treatment showed the following results of tolerance and efficacy: Systemic side-reactions registered during therapy were only mild and transient and occurred in the average after 3% of the AGD injections and after 10% of the TA injections. Local reactions over 5 cm diameter were registered after 7% in the AGD group and after 9% in the TA group. Before therapy there was no significant difference (p greater than 0.05) between the groups; after three years of therapy the AGD injections had resulted in a mean net rise of specific IgG of 220% (significant, p = 0.001); during the same time, TA injections had resulted in a final net increase of 10% (not significant, p greater than 0.05). Both treatment forms did not lead to any statistically relevant changes of specific IgE values. After three years of hyposensitization treatment, patients of both groups had improved; but an advantage was documented for patients treated with AGD on the basis of scores for objective assessment as well as for registered symptom and medication scores.
Dermatologische Klinik, Universität Zürich.
K
K
Mühlethaler
B
B
Wüthrich
A G
AG
Peeters
N
N
Terki
J P
JP
Girard
E
E
Frank
D000328:Adult; D000485:Allergens; D000080384:Allergoids; D000536:Aluminum Hydroxide; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*; D014443:Tyrosine
D000485:Allergens; D000080384:Allergoids; D010936:Plant Extracts; D014443:Tyrosine; D000536:Aluminum Hydroxide
Zur Hyposensibilisierung der Pollinose. Ergebnisse einer kontrollierten Studie über drei Jahre mit zwei Depotallergoid-Graspollenextrakten: Aluminiumhydroxid-adsorbiertes Allergoid (AGD) und Tyrosin-adsorbiertes Allergoid (TA).