Nicotine receptors in the mammalian brain.
Nicotine is a drug of abuse that presumably exerts its psychoactive effect through its interactions with nicotine binding sites in the central nervous system. Among its potential sites of action are the neuronal nicotinic acetylcholine receptors and the neuronal alpha-bungarotoxin binding sites. In this review we focus on the neuronal nicotinic acetylcholine receptors, their diversity, distribution, and functions as nicotine receptors or as mediators of synaptic transmission in the mammalian brain. We find that the complexity characteristic of the gene family encoding the subunits of these receptors is reflected both in the pattern of expression of the genes and in the pharmacological diversity of the expressed receptors.
Luetje
C W
CW
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Patrick
J
J
Séguéla
P
P
D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D008322:Mammals; D009474:Neurons / Q000502:physiology; D011978:Receptors, Nicotinic / Q000235:genetics / Q000502:physiology*
D011978:Receptors, Nicotinic