[Arteriosclerosis obliterans. Treatment with angiotensin-converting enzyme inhibitors].
We compare the effects of two of the main angiotensin convertase enzyme inhibitors, captopril and enalapril, aiming to evaluate their effects in the arterial circulation performance, micro-circulation, and changes in regional blood flow, assuming their property of lowering the angiotensin II blood levels, a very strong peripheral vasoconstrictor. We studied 22 patients: all of them with hypertension and/or skin ulcerations, dropping out those who had venous. They were evaluated periodically, clinically and with photoelectric plethysmography of lower extremities. To interpret the traces we designed an ideogram which gathered the plethysmographic behavior before and after the treatment. Nearly 80% showed considerable improvement in pain, functional capacity and plethysmographic traces patterns. healing of the ulcerations was achieved in all case. We propose some hypothesis to explain the good effect that we have observed.
Hospital Central Sur de Concentración Nacional, Petróleos Mexicanos, México, D.F.
A
A
Orea
R
R
Valdés
L
L
Niebla
R
R
Rivas
B
B
Camacho
D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy* / Q000503:physiopathology; D002216:Captopril / Q000627:therapeutic use*; D004341:Drug Evaluation; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance / Q000187:drug effects; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000187:drug effects
D004656:Enalapril; D002216:Captopril
Aterosclerosis obliterante. Tratamiento con inhibidores de la enzima convertidora de angiotensina (ECA).