Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).
Part I of this article, which appeared in the previous issue of the Journal, covered the following agents: histamine H2-receptor antagonists (cimetidine, ranitidine, famotidine, nizatidine); muscarinic-M1-receptor antagonists (pirenzepine); proton pump inhibitors (omeprazole); site-protective agents (colloidal bismuth subcitrate, sucralfate); antacids and prostaglandin analogues; antiemetics and prokinetics (metoclopramide, domperidone, cisapride); and antispasmodics. In Part II, we consider the anti-inflammatory salicylates, nonspecific antidiarrhoeal agents, laxatives and cathartics.
Department of Medical Gastroenterology, Odense University Hospital, Denmark.
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K
Lauritsen
L S
LS
Laursen
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J
Rask-Madsen
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D002400:Cathartics / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D012459:Salicylates / Q000493:pharmacokinetics / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000930:Antidiarrheals; D002400:Cathartics; D005765:Gastrointestinal Agents; D012459:Salicylates