Comparative study of the effects of zopiclone and placebo on respiratory function in patients with chronic obstructive respiratory insufficiency.
Long-term administration of zopiclone in 6 patients with severe chronic obstructive respiratory insufficiency with stable ventilatory function did not demonstrate any depressant action on respiratory blood gases recorded during the daytime and in ambient air. The sedative action of this agent was manifested by a modest decrease in ventilatory response parameters which, however, was not statistically significant. Polysomnographic recordings did not reveal any worsening of desaturation periods both with respect to incidence and amplitude. There was a non-significant trend towards an increase in the number of obstructive apnoea episodes without any notable ventilatory impact.
Service de Pneumologie CHU Hôpital de Bois-Guillaume, Rouen, France.
J F
JF
Muir
C
C
DeFouilloy
P
P
Broussier
R
R
Locquet
F
F
Maillard
D000403:Airway Resistance / Q000187:drug effects*; D053961:Azabicyclo Compounds; D002940:Circadian Rhythm / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D006993:Hypnotics and Sedatives; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood*; D010879:Piperazines / Q000008:administration & dosage*; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012129:Respiratory Function Tests; D016037:Single-Blind Method; D012894:Sleep Stages / Q000187:drug effects
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D010100:Oxygen