Disulfiram-induced hepatitis.
We reported a case of disulfiram-induced hepatitis with unique clinical features and compared our case with others in the literature. Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy. Subsequent liver biopsy showed low-grade lobular hepatitis. After disulfiram therapy was discontinued, symptoms subsided and results of liver function tests returned to normal.
Veterans Affairs Medical Center, Medicine Service, Johnson City, TN 37684.
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S
Kahn
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JB
Farnum
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E
Thomas
D000437:Alcoholism / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004221:Disulfiram / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D004221:Disulfiram