Surgical treatment of hematogenous vertebral Aspergillus osteomyelitis.
Three cases of Aspergillus fumigatas vertebral osteomyelitis failed courses of medical treatment. Each was subsequently treated with anterior vertebral debridement and posterior segmental spinal instrumentation. Despite poor nutritional and immune systems, resolution of the infection and subsequent anterior ankylosis occurred in each patient, with follow-up ranging from 1 to 3 years. If patients with aspergillus vertebral osteomyelitis do not respond to medical treatment, early surgical debridement and stabilization in combination with intravenous amphotericin B can lead to resolution and bony ankylosis.
Division of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri.
K H
KH
Bridwell
J W
JW
Campbell
S J
SJ
Barenkamp
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000601:surgery*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D003646:Debridement; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery; D008297:Male; D009984:Orthopedic Fixation Devices; D010019:Osteomyelitis / Q000209:etiology / Q000601:surgery*; D013122:Spinal Diseases / Q000209:etiology / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000601:surgery
D000666:Amphotericin B