Ad libitum alcohol ingestion does not induce renal IgA deposition in mice.
This study investigated the induction of alcohol abuse related IgA glomerulonephritis in mice, a disease we have previously described in humans and in rats with noncirrhotic alcoholic liver disease. A commercial liquid diet was fed ad libitum to 115 mice from three strains: C57BL/6J, BALB/cJ, and C3H/HeJ. Animals were divided into two groups: 60 received 30% of their caloric intake as ethanol--alcoholized; and 55 were fed the same calorie count in the form of glucose-controls. Mice were killed at weekly intervals after 4 to 10 weeks of liquid diet ingestion. No diagnostic renal pathology was observed.
Department of Pathology, School of Medicine, University of New Mexico, Albuquerque 87131.
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Smith
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Hoy
D000428:Alcohol Drinking / Q000502:physiology*; D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D005235:Fatty Liver, Alcoholic / Q000473:pathology; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D007070:Immunoglobulin A / Q000032:analysis; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D007070:Immunoglobulin A