Through the looking glass: the discovery of supercoiled DNA.
The discovery of supercoiled DNA was first reported 25 years ago in a paper entitled, 'The Twisted Circular Form of Polyoma Viral DNA' by Vinograd, Lebowitz, Radloff, Watson and Laipis. This personal reflection describes the different experimental and conceptual processes that eventually led to the discovery as they actually occurred.
Department of Microbiology, University of Alabama, Birmingham 35294.
J
J
Lebowitz
D004278:DNA, Superhelical / Q000266:history*; D049673:History, 20th Century
D004278:DNA, Superhelical