Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells.
Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress response.
Friedrich-Miescher-Laboratory, Max-Planck-Society, Tübingen, FRG.
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Jentsch
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Seufert
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D002477:Cells / Q000201:enzymology*; D005057:Eukaryotic Cells / Q000201:enzymology*; D008025:Ligases / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases
D044767:Ubiquitin-Protein Ligases; D008025:Ligases