[The cellular localization of the fertility alpha 2-microglobulin in tumors of the reproductive system].
Seventy-five samples of human tumors were examined immunohistochemically for fertility alpha-2-microglobulin also known as progesterone-associated protein of the endometrium. The protein was detected in 35.7% (5 of 14) endometrial cancer samples and in 20% (2 of 10) of ovarian malignancies. Tumors of the stomach, colon, breast, lung and some other sites failed to reveal the antigen with the exception of a single case of pulmonary adenocarcinoma which showed the ectopic expression of the protein. Fertility alpha-2-microglobulin is stage-specific tissue marker of the endometrium. It is expressed at the final stage of cell differentiation and is partially lost in cancer.
K K
KK
Pugachev
Iu S
IuS
Tatarinov
T Iu
TIu
Tsareva
I B
IB
Shimbireva
S K
SK
Krivonosov
D004717:Endometrium / Q000032:analysis / Q000378:metabolism; D005260:Female; D005333:Fetus; D005833:Genital Neoplasms, Female / Q000032:analysis* / Q000378:metabolism; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D010920:Placenta / Q000032:analysis / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis* / Q000378:metabolism
D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins
Kletochnaia lokalizatsiia al'fa-2-mikroglobulina fertil'nosti v opukholiakh reproduktivnoĭ sistemy.