Quantitative assessment of blood flow in pediatric recipients of renal transplants.
We applied a renal blood flow (RBF) quantification technique to pediatric data, which depends minimally on bolus shape, uses a conventional radiopharmaceutical 99mTc-DTPA, and generates a value for RBF as a percentage of cardiac output (RBF/CO). Mean RBF was 16.9% (+/- 4.8) for normal transplants, 13.1% (+/- 2.9) for transplants undergoing mild-to-moderate chronic rejection, 7.9% (+/- 1.3) for those with mild acute rejection and 3.3% (+/- 1.4) for those with moderate-to-severe acute rejection. Very low blood flow values within 24 hr following transplantation may have prognostic significance. Patients who required transplant-nephrectomy had significantly lower RBF/CO values than children who retained their allograft.
Ash
J
J
Hospital for Sick Children, Toronto, Ontario, Canada.
DeSouza
M
M
Peters
M
M
Wilmot
D
D
Hausen
D
D
Gilday
D
D
D000293:Adolescent; D002302:Cardiac Output / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection / Q000502:physiology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012079:Renal Circulation / Q000502:physiology*; D016284:Technetium Tc 99m Pentetate
D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate