Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.
Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice.
O'Sullivan
J
J
Squibb Institute for Medical Research, Princeton, NJ 08543-4000.
McCullough
J
J
Johnson
J H
JH
Bonner
D P
DP
Clark
J C
JC
Dean
L
L
Trejo
W H
WH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D002850:Chromatography, Gel; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000145:classification / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D051379:Mice; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy; D014640:Vancomycin / Q000494:pharmacology; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D010456:Peptides, Cyclic; C066083:janthinocin A; C066084:janthinocin B; C066085:janthinocin C; D014640:Vancomycin