Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease.
Rich
D H
DH
School of Pharmacy, University of Wisconsin-Madison 53706.
Green
J
J
Toth
M V
MV
Marshall
G R
GR
Kent
S B
SB
D010450:Endopeptidases / Q000378:metabolism*; D015684:Gene Products, pol / Q000378:metabolism*; D016333:HIV Protease; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D015684:Gene Products, pol; D009842:Oligopeptides; D011480:Protease Inhibitors; C063780:N-acetylseryl-leucyl-asparaginyl(phenylalanyl-hydroxyethylamino-prolyl)isoleucyl-valyl methyl ester; D010450:Endopeptidases; D016333:HIV Protease