A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist.
The effect of MK-329, a potent, orally active, nonpeptidal cholecystokinin (CCK) antagonist, was measured on the gastric emptying rate of a solid meal in cats. External scintigraphy of cats that had been fed a meal of technetium-99m-(99mTc) labeled rabbit liver and light cream allowed the measurement of the emptying rates of either the liquid or solid portion of a meal under physiologic conditions. In cats, liquids emptied 2.6 times faster than solids [163 +/- 11 min vs. 62 +/- 3 min (mean +/- s.e.)]. At 3 or 10 mg/kg p.o., MK-329 gastric emptying was significantly accelerated, with the mean half-time of emptying being decreased by 34 +/- 11% (mean +/- s.e.) of the control half-times (p less than 0.02). Using only responders (five of six animals), mean half-time was decreased by 55 +/- 4% of the control half-times. CCK is important in regulating the emptying of solid food from the stomach because the CCK antagonist MK-329 accelerates that emptying.
Department of Pharmacology, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
R J
RJ
Gould
C
C
Fioravanti
P G
PG
Cook
H F
HF
Solomon
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002415:Cats; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D020109:Devazepide; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013268:Stimulation, Chemical; D013270:Stomach / Q000000981:diagnostic imaging; D016284:Technetium Tc 99m Pentetate; D013671:Technetium Tc 99m Sulfur Colloid
D001570:Benzodiazepinones; D015609:Organotechnetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid; D004369:Pentetic Acid; D002766:Cholecystokinin; D020109:Devazepide; D016284:Technetium Tc 99m Pentetate