[Cure of amineptine dependence with clonidine?].
Two patients with dependence to amineptine were treated with clonidine which is used in morphine withdrawals. After some days, the two patients stopped amineptine intake. The only way of action seems to be the potentialization of amineptine by clonidine, as probed in mice, or the increase of sensibilization of alpha 2 adrenoreceptors.
Pharmacologie Clinique et Pharmacovigilance, C.H.R. de Nantes.
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M
Bourin
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Gest
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Baudot
D000328:Adult; D000929:Antidepressive Agents, Tricyclic; D003000:Clonidine / Q000627:therapeutic use*; D003986:Dibenzocycloheptenes; D005260:Female; D006801:Humans; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000188:drug therapy*
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011597:amineptin; D003000:Clonidine
Sevrage d'une dépendance à l'amineptine par la clonidine?