Methods for measuring GFR with technetium-99m-DTPA: an analysis of several common methods.
Several commonly used scintigraphic methods of GFR measurement were evaluated. Forty-three adult patients with a wide range of ages and renal function were studied. The two-sample plasma method of Russell and the urinary method of Jackson were the most accurate methods overall. The one-sample plasma method of Russell, the volume of distribution method of Fawdry, and a terminal slope method were less reliable, especially at low (0-60 ml/min) GFRs. The renal uptake method of Gates correlated poorly to the standards at all GFR levels even when corrected for body surface area or blood volume. The Russell two point and Jackson urinary GFR's can be used as complementary techniques and are recommended as primary methods of scintigraphic GFR determination.
Department of Radiology, Fitzsimons Army Medical Center, Aurora, Colorado 80045-5001.
J S
JS
Mulligan
P W
PW
Blue
J A
JA
Hasbargen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005069:Evaluation Studies as Topic; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D008297:Male; D008722:Methods; D008875:Middle Aged; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012016:Reference Values; D016284:Technetium Tc 99m Pentetate
D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate