Polyoxygenated sterols and triterpenes: chemical structures and biological activities.
Cholesterol and other sterols are precursors of many hormones of vertebrates (pregnane, androstane, estrane derivatives), invertebrates (ecdysteroids) and even of plants (brassinoids). The normal biosynthetic processes which begin by a series of oxidations lead to a family of compounds, some of which exhibit a wide variety of biological activities. Among the latter, those well-established are their inhibitory effect on the biosynthesis of cholesterol in mammalian cells, their toxic effect on tumor cells and their ability to modify some immunological responses. None of the members of this family has all of the activities just mentioned. The intensity of the effect depends markedly upon the specific structure of each compound.
Laboratoire de Chimie Organique des Substances Naturelles, UA31, CNRS, Strasbourg, France.
Y H
YH
Ji
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C
Moog
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G
Schmitt
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D000818:Animals; D000924:Anticholesteremic Agents; D002784:Cholesterol / Q000096:biosynthesis*; D006801:Humans; D013261:Sterols / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D013261:Sterols; D014315:Triterpenes; D002784:Cholesterol