[A model of diffusion of anti-cataract drugs into the lens tissue].
For modeling anticataract drugs diffusion into the lens surface tension of drugs, their solubility in nonpolar solvent and drug adsorption at air-water and water-lipid monolayer surface were measured. It has been shown that diffusion of many drugs into the lens is limited by their low solubility in a monolayer phase of the membrane. Catachrom concentration in the lens should be the highest, because it can concentrate at interfaces.
L V
LV
Chasovnikova
V E
VE
Formaziuk
V I
VI
Sergienko
Iu A
IuA
Vlasimirov
D002386:Cataract / Q000188:drug therapy* / Q000378:metabolism; D004058:Diffusion; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics* / Q000627:therapeutic use
D009883:Ophthalmic Solutions
Modelirovanie protsessa diffuzii antikataraktal'nykh lekarstvennykh preparatov v glub' khrustalika glaza.