[The use of metoprolol with calcium antagonists of different mechanisms of action (diltiazem and nifedipine) in patients with stenocardia of effort].
The use of metoprolol combined with nifedipine and diltiazem was studied and compared in 32 patients suffering from coronary disease associated with angina pectoris of effort. The drug combinations indicated appeared equally effective in patients with angina pectoris, functional class III. In patients with angina pectoris of effort, functional classes III-IV, the combined use of metoprolol and diltiazem turned out superior as compared with nifedipine which is related to different hemodynamic effects of the drugs.
A B
AB
Guliev
V P
VP
Lupanov
B A
BA
Sidorenko
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D004110:Diltiazem / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010807:Physical Endurance / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects; D016037:Single-Blind Method
D004110:Diltiazem; D008790:Metoprolol; D009543:Nifedipine
Primenenie metoprolola s antagonistami kal'tsiia razlichnogo mekhanizma deĭstviia (diltiazem i nifedipin) u bol'nykh stenokardieĭ napriazheniia.