Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132.
Subcutaneous or intraperitoneal injection of recombinant human granulocyte-macrophage colony-stimulating factor, interleukin 3, or mouse tumour necrosis factor alpha, but not recombinant human interferon gamma, platelet-derived growth factor, or transforming growth factor beta caused selective eosinophilia of the pulmonary airways in the guinea pig. Unlike responses to platelet-activating factor, there was no attendant detectable airway hyperreactivity, but in common with responses to platelet-activating factor, eosinophilia of the airways was prevented by pretreatment with ketotifen or AH21-132. Cytokines or lymphokines may contribute to pulmonary eosinophilia in diseases such as asthma.
Preclinical Research, Sandoz Ltd., Basel, Switzerland.
M A
MA
Kings
I
I
Chapman
A
A
Kristersson
S
S
Sanjar
J
J
Morley
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D006168:Guinea Pigs; D007665:Ketotifen / Q000494:pharmacology; D007958:Leukocyte Count; D008222:Lymphokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D008297:Male; D009287:Naphthyridines / Q000494:pharmacology; D011657:Pulmonary Eosinophilia / Q000209:etiology*; D011994:Recombinant Proteins; D012129:Respiratory Function Tests
D016207:Cytokines; D008222:Lymphokines; D009287:Naphthyridines; D011994:Recombinant Proteins; C044843:AH 21-132; D007665:Ketotifen