Collagen gene expression and tooth development. An overview.
The regulation aspects of type I and type III collagen gene expression are examined and the relationships with tooth morphogenesis and differentiation are discussed. Type I and III collagens constitute the major molecular proteins of the dental tissues. In addition the collagen gene expression in the mesenchyme derived odontoblasts represents an important step in the cytodifferentiation at the mesenchymal level. Furthermore, odontoblasts seem to synthesize only type I and type I trimer collagens, but not type III collagen. Therefore, the aim of this overview is to describe the molecular mechanisms that control the expression of specific collagen genes during the process of odontoblast differentiation. The available data support the main transcriptional control and argue for the existence of an independent and developmental regulation during collagen gene expression in odontoblast cells.
Institut Pasteur de Lyon, UA CNRS 602, Lyon.
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MB
Andujar
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H
Magloire
D000818:Animals; D003094:Collagen / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D009805:Odontogenesis / Q000235:genetics*
D003094:Collagen