Influence of cefodizime on chemotaxis and the respiratory burst in neutrophils from diabetics.
The effect of cefodizime on the function in vitro of neutrophils from poorly-controlled, non-insulin-dependent diabetics was demonstrated by the chemotactic index and by chemiluminescence. Without cefodizime treatment, the chemotactic index for diabetic neutrophils was significantly lower than that for healthy controls (1.0 +/- 0.1 vs 3.6 +/- 0.7; mean +/- S.E.M., P less than 0.01). When neutrophils were pretreated with cefodizime at 1 or 10 mg/l, cefodizime restored the chemotactic activity of diabetic neutrophils (1.0 +/- 0.1 vs 2.7 +/- 0.3, P less than 0.01), but did not affect the activity in healthy controls. Conversely, cefodizime at 100 mg/l had no enhancing effect on diabetic neutrophil chemotaxis, but decreased the chemotactic activity of healthy neutrophils (1.1 +/- 0.2 vs 3.6 +/- 0.7, P less than 0.01). A difference in neutrophil chemiluminescence was also found between diabetics and healthy subjects but no influence of cefodizime on chemiluminescence was noted in neutrophils from either diabetics or healthy subjects.
Shaio
M F
MF
Department of Parasitology and Tropical Medicine, National Defence Medical Center, Taipei, Taiwan, Republic of China.
Chang
F Y
FY
D000166:Acridines; D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects
D000166:Acridines; C033472:10,10'-dimethyl-9,9'-biacridinium; D002439:Cefotaxime; C033356:cefodizime