Regeneration of cranial suture and bone plate lesions in rabbits. Implications for positioning of osteotomies.
The positioning of osteotomies in intramembranous cranial bone was studied by exploring the pattern of bone regeneration in growth areas (the sutural region) as compared to that of the bone plate proper. Trephine defects in the left coronal suture area and the right parietal bone were produced in fifty-nine young rabbits. A pilot study to refine operative and analytical methods comprised 22 animals. The experiments were terminated at one, three, and six weeks after surgery. The bone regenerative response was assessed by x-ray planimetry, plain microscopy, enzyme histochemistry, and fluorescent labelling. Only minor divergences in healing capacity between the two defects were found. No adverse effects on the growth process were indicated. As to clinical management, the findings suggest that osteotomies designed to traverse sutural areas will, under normal circumstances, regenerate in a similar manner and rate to adjoining bone plates.
Dept. of Plastic Surgery, Sahlgrenska Hospital, Göteborg, Sweden.
P
P
Alberius
S
S
Isaksson
B
B
Klinge
S
S
Sjögren
J
J
Jönsson
D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D003393:Cranial Sutures / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005455:Fluorescent Antibody Technique; D005624:Frontal Bone / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D010027:Osteotomy / Q000379:methods*; D010294:Parietal Bone / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D011817:Rabbits
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase