Immunocompetent cells and epithelial cell modifications in molluscum contagiosum.
We studied lesions of molluscum contagiosum with a panel of monoclonal antibodies to determine the phenotype of infiltrating cells and antigen modifications of infected keratinocytes. Our data indicate (1) a complete lack of immunocompetent cells in the viral lesions, and simultaneously a loss of B2-microglobulin reactivity by molluscum bodies, a cellular activation of EGF and transferrin receptors and expression of CD36 antigen of these bodies; (2) a moderate infiltrate of activated T cells and monocytes in the underlying epidermis; (3) an increase of Langerhans cell density and a CD36 expression by the surface of upper layer keratinocytes in the perilesional epidermis.
Viac
J
J
Inserm U209, CNRS URA 601, Clinique Dermatologique, Hôpital E. Herriot, Lyon, France.
Chardonnet
Y
Y
D004848:Epithelium / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D066246:ErbB Receptors / Q000276:immunology / Q000378:metabolism; D006684:HLA-DR Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D007801:Langerhans Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D008976:Molluscum Contagiosum / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D011990:Receptors, Transferrin / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D001613:beta 2-Microglobulin / Q000276:immunology / Q000378:metabolism
D006684:HLA-DR Antigens; D011990:Receptors, Transferrin; D001613:beta 2-Microglobulin; D066246:ErbB Receptors