Protein kinase C and tumor promoters.
The complexity of PKC has made it difficult to define the precise biochemical processes associated with the various PKC-related cellular responses observed. In the past year, we have seen progress in complementary approaches that are helping to solve the puzzles. These include purification and characterization of individual isozymes, expression of normal and mutant PKCs, immunolocalization, and identification of specific activators and inhibitors. All of these will be useful in identifying the primary targets of PKC phosphorylation and their function.
W. Alton Jones Cell Science Center, Lake Placid, New York.
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D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D010703:Phorbol Esters / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000201:enzymology
D007527:Isoenzymes; D010703:Phorbol Esters; D011493:Protein Kinase C