Central nervous system effects of human immunodeficiency virus type 1.
Following its early entry into the central nervous system (CNS), HIV-1 alters cerebral cell architecture and may subsequently affect higher cognitive functions, leading eventually in some patients to HIV-1 encephalopathy. The CNS may also be the target of opportunistic infections and malignancy secondary to HIV-1 immunosuppression. Studies at the cellular, anatomical, and behavioral levels present evidence for significant involvement of the CNS in HIV-1 disease, while initial reports of treatment strategies hold promise for providing some amelioration in affected individuals.
Bridge
T P
TP
Division of Intramural Research, National Institute of Mental Health, Bethesda, Maryland 20892.
Ingraham
L J
LJ
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D015497:HIV-1; D006801:Humans; D015994:Incidence; D014481:United States / Q000453:epidemiology