Lobar atrophy with pontine neuronal chromatolysis ("ballooned" neurons).
A 64-year-old man developed progressive dementia over a period of 11 years. Postmortem examination showed severe atrophy of the temporal lobes of the brain with extensive neuronal loss and a remarkable alteration of the neuronal perikaryon--the "ballooned" neuron--restricted to the nuclei of the basis pontis. No neuritic plaques, neurofibrillary tangles, or Pick bodies were seen.
Department of Pathology, (Neuropathology), University of Massachusetts Medical Center, Worcester 01665.
C F
CF
Lippa
T W
TW
Smith
U
U
DeGirolami
D001284:Atrophy; D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology*; D009562:Nissl Bodies / Q000473:pathology; D011149:Pons / Q000473:pathology*