Intraluminal vascular ultrasound: preliminary report of dimensional and morphologic accuracy.
The role of intraluminal ultrasound for diagnosis and monitoring treatment of vascular disease has yet to be defined. This study evaluated the dimensional precision and morphologic accuracy of an intraluminal ultrasound system which consists of a 5.5 French external diameter ultrasonic catheter with a central lumen for passage of a guidewire. Ultrasound images from five in-vitro human and three porcine arterial segments and two in-vivo arteriosclerotic canine arteries were compared to dimensions obtained from arteriograms and from sections of the specimens. Each gross and histological specimen and ultrasound image was scaled, photographed and enlarged up to 20 times and measured for vessel intraluminal and adventitial or outer diameter and wall thickness. Intraluminal and outer diameters and wall thickness from normal in-vitro specimens correlated significantly with dimensions obtained from histologic specimens (r = 0.99, p less than 0.005 for internal and outer diameters and r = 0.73, p less than 0.005 for wall thickness). The mean differences of luminal diameters measured from the vessels supported within a silicone rubber mold was 0.05 +/- 0.09 mm (n = 20). Diameters of outer diameter and wall thickness were less reliably defined, the average margin of error being 0.49 +/- 0.39 mm and 0.29 +/- 0.26 mm, respectively. The mean difference between in-vivo ultrasound and arteriographic diameters was 0.61 +/- 0.38 mm (n = 12). Correlation of luminal diameters between ultrasound and arteriogram was significant (r = 0.76, p less than 0.02). The ultrasound images also differentiated a laminated appearance of normal vessel anatomy from non-uniform or dense signals seen in atherosclerotic lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
Kopchok
G E
GE
Department of Surgery, Harbor-UCLA Medical Center, Torrance 90509.
White
R A
RA
Guthrie
C
C
Hsiang
Y
Y
Rosenbaum
D
D
White
G H
GH
D000792:Angiography / Q000592:standards; D000818:Animals; D000886:Anthropometry; D001158:Arteries / Q000473:pathology*; D005069:Evaluation Studies as Topic; D006801:Humans; D007089:Image Enhancement; D013552:Swine; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*; D014652:Vascular Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology