Presumed choroidal metastasis of Merkel cell carcinoma.
Merkel cell carcinoma is a rare skin tumor of neural crest origin and is part of the amine precursor uptake and decarboxylase system. It typically occurs on the face of elderly people. Distant metastasis is almost uniformly fatal. Choroidal metastasis, to our knowledge, has not been described. We report a patient with Merkel cell carcinoma who had a synchronous solid choroidal tumor and a biopsy-proven brain metastasis. Our 56-year-old patient presented with a rapidly growing, violaceous preauricular skin tumor. Computed tomography of the head disclosed incidental brain and choroidal tumors. Light and electron microscopy of biopsy specimens of both the skin and the brain lesions showed Merkel cell carcinoma. Ophthalmoscopy, fluorescein angiography, and A and B echography revealed a solid choroidal mass. The brain and skin tumors responded well to irradiation. A radioactive episcleral plaque was applied subsequently to the choroidal tumor. All tumors regressed, and the patient was doing well 28 months later. To our knowledge this is the first case of presumed choroidal metastasis of Merkel cell carcinoma.
Small
K W
KW
Duke University Medical Center, Durham, NC 27712.
Rosenwasser
G O
GO
Alexander
E
E
Rossitch
G
G
Dutton
J J
JJ
D001706:Biopsy; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D015266:Carcinoma, Merkel Cell / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D002830:Choroid Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D007457:Iodine Radioisotopes