[Does induction with midazolam decrease stress response during anesthesia?].
The effects of midazolam on stress response during surgery compared with thiamylal were studied. Twelve patients were divided into 2 groups at random; midazolam group and thiamylal group. Anesthesia was induced with midazolam 0.2 mg.kg-1 or thiamylal 4 mg.kg-1 in each group, and maintained with O2 2 l.min-1, N2O 4 l.min-1 and enflurane. The plasma concentration of catecholamine was measured at preinduction, 10, 30, 60, 120 and 180 minutes after intubation. No significant differences were seen between 2 groups in plasma concentration of catecholamine. In midazolam group, plasma concentration of epinephrine decreased significantly 10 minutes after intubation as compared with preinduction level. The plasma concentration of norepinephrine in midazolam group tended to decrease. In thiamylal group, plasma concentration of norepinephrine tended to increase and increased significantly at 120 and 180 minutes after intubation as compared with preinduction level. These results suggest that induction with midazolam suppresses stress response during anesthetic induction and surgery more intensely than induction with thiamylal.
Nishiyama
T
T
Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu.
Hirasaki
A
A
Odaka
Y
Y
Saito
M
M
Seto
K
K
D000328:Adult; D000368:Aged; D000777:Anesthetics / Q000494:pharmacology*; D006801:Humans; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D013840:Thiamylal / Q000494:pharmacology*
D000777:Anesthetics; D013840:Thiamylal; D008874:Midazolam