Treatment of Frey's syndrome with topical 2% diphemanil methylsulfate (Prantal): a double-blind evaluation of 15 patients.
Fifteen patients with severe gustatory sweating after total parotidectomy and facial nerve preservation were asked to take part in a double-blind study. All patients were alternatively treated with topically applied placebo and topically applied 2% diphemanil methylsulfate (an anticholinergic agent). A 10-day period was allowed between applications for return of symptoms. Two-percent diphemanil methylsulfate provided partial relief in 33.3% of patients and total relief in 40% of patients. Involvement of the hairy temporal line region with gustatory sweating was the main reason for failure. Duration of relief varied from 2 to 4 days. The only side effect was dryness of the mouth noted in two patients.
Department of Otolaryngology-Head and Neck Surgery Hopital Laennec, Paris, France.
O
O
Laccourreye
B
B
Bonan
D
D
Brasnu
H
H
Laccourreye
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000627:therapeutic use; D010880:Piperidines / Q000008:administration & dosage* / Q000627:therapeutic use; D013547:Sweating, Gustatory / Q000188:drug therapy* / Q000601:surgery
D010276:Parasympatholytics; D010880:Piperidines; C028209:diphemanil methylsulfate