Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160.
The development of a vaccine to provide protective immunity to human immunodeficiency virus type 1 (HIV-1), the virus causing AIDS, would be the most practical method to control its spread. Subunit vaccines consisting of virus envelope glycoproteins, produced by recombinant DNA technology, are effective in preventing viral infections. We have now used this approach in the development of a candidate AIDS vaccine. Chimpanzees were immunized with recombinant forms of the HIV-1 glycoproteins gp120 and gp160 produced in Chinese hamster ovary cells, and then challenged with HIV-1. The control and the two animals immunized with the gp160 variant became infected within 7 weeks of challenge. The two animals immunized with the gp120 variant have shown no signs of infection after more than 6 months. These studies demonstrate that recombinant gp120, formulated in an adjuvant approved for human use, can elicit protective immunity against a homologous strain of HIV-1.
Department of Immunobiology, Genentech, Inc., South San Francisco, California 94080.
P W
PW
Berman
T J
TJ
Gregory
L
L
Riddle
G R
GR
Nakamura
M A
MA
Champe
J P
JP
Porter
F M
FM
Wurm
R D
RD
Hershberg
E K
EK
Cobb
J W
JW
Eichberg
D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D015686:Gene Products, env / Q000276:immunology*; D015483:HIV Antibodies / Q000032:analysis; D015488:HIV Antigens / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology* / Q000378:metabolism; D019302:HIV Envelope Protein gp160; D015497:HIV-1 / Q000276:immunology*; D002679:Pan troglodytes; D011498:Protein Precursors / Q000276:immunology*; D014612:Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
D015703:Antigens, CD; D015704:CD4 Antigens; D015686:Gene Products, env; D015483:HIV Antibodies; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160; D011498:Protein Precursors; D014612:Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines