[The quantitative characteristics of the metabolism of antitumor compounds].
Methodical approaches to quantitative study of biotransformation of antitumor drugs have been described and classified. Most widely used types of models have been described. Proposed algorithm of interpretation of obtained experimental data may be used for selection of suitable model description of a compound and characterization of its pharmacokinetic properties.
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SV
Geodakian
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001711:Biotransformation; D006801:Humans; D008433:Mathematics; D008657:Metabolic Clearance Rate; D008954:Models, Biological
D000970:Antineoplastic Agents
Kolichestvennye kharakteristiki metabolizma protivoopukholevykh soedineniĭ.