[The use of the antipyrine test for studying microsomal drug oxidation].
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors and inhibitors on the liver microsomal enzyme activity. The research methods are described and the data on the effects of different environmental factors on antipyrine metabolism are presented. The peculiarities of using the drug as a model for studying the effects of different environmental factors on the drug metabolism are formulated.
A P
AP
Viktorov
A T
AT
Rybak
D000818:Animals; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008658:Inactivation, Metabolic; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects
D000983:Antipyrine
Ispol'zovanie antipirinovogo testa pri izuchenii mikrosomal'nogo okisleniia lekarstvennykh sredstv.