Efficacy of isosorbide-5-mononitrate on painful and silent myocardial ischemia after myocardial infarction.
The anti-ischemic efficacy of isosorbide-5-mononitrate, 20 mg 3 times daily, on silent myocardial ischemia after myocardial infarction was studied in 28 Chinese patients with use of 48 hours of ambulatory electrocardiographic monitoring in a randomized, crossover, single-blind, placebo-controlled study. Isosorbide mononitrate reduced both painful and painless episodes of ischemia compared with placebo. The number of total ischemic episodes was reduced 88%, duration of ischemia 94%, time-ischemia integral 95%, and total maximal ST-segment depression 86% (p less than 0.01). The drug did not alter the heart rate and blood pressure, and had no evident adverse effect. Thus, isosorbide mononitrate is effective and well tolerated in postinfarction patients with silent ischemia.
Feng
J Z
JZ
Guangdong Provincial Cardiovascular Institute, Guangzhou, People's Republic of China.
Feng
X H
XH
Schneeweiss
A
A
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D016037:Single-Blind Method
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate