Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure.
We report the case history of a 54-year-old man who developed a fatal neurological disorder 4 years after a successful tympanoplasty with homograft pericardium. The final diagnosis of this case was Creutzfeldt-Jakob disease. This infectious spongiform encephalopathy is probably caused by a slow virus that can be transmitted by transplantation materials. The possible accidental transmission of Creutzfeldt-Jacob disease by the use of homograft materials in otologic surgery is discussed.
Department of Otolaryngology, University of Amsterdam, The Netherlands.
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Tange
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Troost
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Limburg
D002540:Cerebral Cortex / Q000473:pathology; D002920:Cialit; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000637:transplantation*; D013997:Time Factors; D014021:Tissue Preservation; D014184:Transplantation, Homologous; D014433:Tympanoplasty
D002920:Cialit