Embryonic resistance to chemical and physical factors: manifestation, mechanism, role in reproduction and in adaptation to ecology.
Chemical and physical factors may adversely affect embryonic development. As an example of chemical factors, the effects of diabetic metabolic factors on embryonic development in mammals was reviewed. The existence of a stage-dependent reaction of embryos was found. At preimplantation stages diabetic metabolic factors are embryotoxic and lethal, and the blastocysts reacted by an "all-or-none" response. Early somite embryos showed a higher resistance to the effects of diabetic metabolic factors resulting in various types of malformations. Both groups of embryos showed a very high sensitivity to the effects of combined diabetic metabolic factors. Congenital defects in term foetuses were lower than those observed during middle phases of pregnancy because some of the severely malformed embryos resorb during gestation. The effects of temperature on embryonic development were presented as an example of physical influences. In man, hyperthermia in pregnancy seems to correlate with defects in the development of the nervous and skeletal systems. In domestic animals, changes in environmental temperature correlated with depressions of reproduction rate. In laboratory animals, hyperthermia caused the development of congenital malformations. Stage-dependent as well as genetic differences in embryonic susceptibility to hyperthermia were found. Critical periods in sensitivity of embryos to hyperthermic influences were also observed. It has been shown that, in spite of similar external manifestations of the reaction of embryos to effects of diabetes and hyperthermia, the mechanism of these reactions was different. High resistance of early reptile and bird embryos to influences of temperature was considered as an example of morphofunctional adaptations in early embryogenesis of vertebrates to their development in terrestrial conditions.
Zusman
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Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Ornoy
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D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology*; D005314:Embryonic and Fetal Development; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005334:Fever / Q000503:physiopathology*; D006801:Humans; D008322:Mammals / Q000196:embryology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D013696:Temperature