Positively charged residues are important determinants of membrane protein topology.
Membrane proteins are found in a variety of conformations, with each protein spanning the membrane a set number of times and adopting a particular orientation. Positively charged residues, often located near the boundaries of transmembrane segments, appear to be involved in specifying the topology of membrane proteins.
Dalbey
R E
RE
Department of Chemistry, Ohio State University, Columbus 43210.
D002462:Cell Membrane / Q000648:ultrastructure; D004563:Electrochemistry; D004926:Escherichia coli; D005057:Eukaryotic Cells; D008565:Membrane Proteins / Q000378:metabolism / Q000648:ultrastructure*; D011487:Protein Conformation; D021382:Protein Sorting Signals
D008565:Membrane Proteins; D021382:Protein Sorting Signals