The effects of new cytochalasins from Phomopsis sp. and the derivatives on cellular structure and actin polymerization.
The effects of ten 10-phenyl-[11]cytochalasins produced by Phomopsis sp. including novel compounds having 5,7- or 6,7-glycol structures and their derivatives, on the cell morphology and actin distribution in C3H-2K cells, as well as on lymphocyte capping and actin polymerization, were examined. The structure-activity relationship reported in the previous papers has been confirmed. The novel glycol type compounds showed little or no activity, suggesting the importance of the perhydroisoindol-1-one nucleus for the manifestation of the cytochalasin actions.
Meiji College of Pharmacy, Tokyo, Japan.
T
T
Hirose
Y
Y
Izawa
K
K
Koyama
S
S
Natori
K
K
Iida
I
I
Yahara
S
S
Shimaoka
K
K
Maruyama
D000199:Actins / Q000096:biosynthesis*; D000818:Animals; D002478:Cells, Cultured; D003572:Cytochalasins / Q000494:pharmacology*; D005260:Female; D005455:Fluorescent Antibody Technique; D007152:Immunologic Capping / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D003904:Mitosporic Fungi / Q000378:metabolism*
D000199:Actins; D003572:Cytochalasins