[Bone resorption and cytokines: the role of IL-1 beta, TNF and lymphotoxin].
Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are soluble factors that play a pivotal role in acute and chronic inflammation. TNF is a 17 Kda protein mainly released by monocytes and macrophages and is a common mediator of toxic shock, cachexia and tumor necrosis. IL-1 was first described as a lymphocyte activating factor and it was then discovered that IL-1 has a number of other biological activities and that there are at least two major types of IL-1 (alpha and beta) which bind to the same receptor. Recently it has been shown that TNF and IL-1 beta have an important role in bone resorption.
Cattedra di Patologia Speciale Odontostomatologica, Università degli Studi G. D'Annunzio, Chieti.
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D'Addona
D001862:Bone Resorption / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D007375:Interleukin-1 / Q000235:genetics / Q000502:physiology*; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000502:physiology*; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000502:physiology*
D007375:Interleukin-1; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha
Riassorbimento osseo e citochine: ruolo della IL-1 beta, del TNF e della linfotossina.