Increased biopterin production in rats with tumors induced by radon inhalation and benzonaphthoflavone administration.
Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this increase occurred several weeks before tumors could be detected radiographically.
Mura
P
P
Laboratoire de Biochimie et de Toxicologie, Jean Bernard Hospital, Poitiers, France.
Morlier
J P
JP
Barriere
M
M
Bredon
P
P
Papet
Y
Y
Chameaud
J
J
D000818:Animals; D001571:Benzoflavones / Q000633:toxicity*; D001708:Biopterins / Q000096:biosynthesis* / Q000652:urine; D003043:Cocarcinogenesis; D009374:Neoplasms, Experimental / Q000209:etiology / Q000378:metabolism* / Q000652:urine; D011886:Radon / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D001708:Biopterins; D019324:beta-Naphthoflavone; D011886:Radon