Unbalanced transmethylation and the perturbation of the differentiated state leading to cancer.
It is proposed that the perturbation of the differentiated state in cancer is related to alterations in DNA methylation as well as to alterations in methylation of other cellular molecules, leading to an imbalance in global cellular methylation. It is hypothesized that the global imbalance in methylation is reflected in the enhanced levels of transmethylation seen in many cancer cell types as well as in a number of undermethylated molecules.
Hoffman
R M
RM
Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla 92093.
D000818:Animals; D004273:DNA, Neoplasm / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm; D008715:Methionine