[Malaria vaccines, a necessity for future control of malaria. Status and future perspectives].
Traditional malaria control is in a crisis on account of chemo-resistance of Plasmodium falciparum and insecticide-resistance of the malaria mosquito. New ways to control malaria have been opened by the possibility of producing a vaccine. Several malaria proteins (e.g. CSP, gp195, Pf155/RESA, GLURP) have been sequenced and it has been shown that most of the proteins have repetitive units. Analyses of T- and B-cell epitopes show that T-cell epitopes are mainly localized to the non-conserved parts of the antigens. Repeated malaria infections, therefore, may be seen as a number of primary infections, which partly explains the very slow development of immunity to the parasite. The initial three vaccination experiments in humans did not succeed in inducing a complete protection of the individual but it showed that partial immunization is possible.
Statens Seruminstitut, Parasitologisk Laboratorium, København.
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E
Petersen
B
B
Høgh
P H
PH
Jakobsen
M
M
Dziegiel
M
M
Borre
S
S
Jepsen
D000953:Antigens, Protozoan / Q000008:administration & dosage* / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D014612:Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis
D000953:Antigens, Protozoan; D014612:Vaccines
Malariavacciner, en nødvendighed for fremtidig malariakontrol. Status og fremtidsudsigter.