Two-event model for carcinogenesis: biological, mathematical, and statistical considerations.
A two-mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time-dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
S H
SH
Moolgavkar
G
G
Luebeck
D000818:Animals; D002274:Carcinogens, Environmental; D004307:Dose-Response Relationship, Radiation; D004812:Epidemiologic Methods; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D011886:Radon / Q000633:toxicity; D051381:Rats; D012306:Risk
D002274:Carcinogens, Environmental; D011886:Radon