[Comparison of the effectiveness of hemodialysis and hemofiltration in the removal of aluminum from the body].
The authors compare the excretion of aluminium from the organism of patients with chronic renal failure during haemodialysis and haemofiltration. Aluminium can be eliminated from the organism only after previous administration of Desferal. Haemodialysis and haemofiltration alone practically do not eliminate aluminium from the organism. During haemodialysis made 24-40 hours after administration of 1 g Desferal (24 procedures, cuprophan plate dialyzer Chiraplat, urea clearance 2.5 ml/s, time 5 hours) the Al serum concentration declined by 41% and the dialyzer clearance for aluminium was during the 60th minute of haemodialysis 0.47 ml/s. During haemofiltration made 24-40 hours after administration of 1 g Desferal (36 procedures, polyamide haemofilter FH 77 on-line system of fluid exchange = 60% body weight) the Al serum concentration declined by 66% and the clearance of the haemofilter for Al was during the 60th minute 0.70 ml/s. Contrary to haemodialyzation treatment of Al intoxication, treatment with haemofiltrations was not associated with clinical complications. Haemofiltration treatment is a safe and effective method for the treatment of Al intoxication and accumulation in patients with chronic renal failure.
Interní oddĕlení Strahov fakultní nemocnice 2 s fakultní poliklinikou UNZ NV hl. m. Prahy.
S
S
Sulková
Z
Z
Laurincová
J
J
Pancírová
D
D
Komonová
A
A
Válek
D000535:Aluminum / Q000032:analysis / Q000097:blood*; D003676:Deferoxamine / Q000008:administration & dosage; D015314:Dialysis Solutions / Q000032:analysis; D006440:Hemofiltration; D006801:Humans; D006435:Renal Dialysis
D015314:Dialysis Solutions; D000535:Aluminum; D003676:Deferoxamine
Srovnání úcinnosti hemodialýzy a hemofiltrace pri odstranování aluminia z organismu.