Haemodynamic effects of long-term endothelin infusion in conscious sheep.
1. Synthetic human endothelin-1 was infused intravenously at 15 micrograms/h for 24 h to examine its cardiovascular actions in five conscious sheep. 2. Endothelin produced a maximum increase in mean arterial pressure (MAP) of +8 mmHg at 8 h, with an increase in calculated total peripheral resistance (CTPR) of +2.6 mmHg/L per min, whilst cardiac output (CO) was unchanged. At 24 h MAP was not significantly elevated, however CTPR had increased by +2.8 mmHg/L per min and CO had decreased by 0.9 L/min. 3. This study shows that long-term administration of endothelin produces sustained arterial vasoconstriction in sheep.
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
A F
AF
Reid
D G
DG
Parkes
J P
JP
Coghlan
B A
BA
Scoggins
J A
JA
Whitworth
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D016232:Endothelins; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D007700:Kinetics; D010455:Peptides / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D016232:Endothelins; D010455:Peptides