[Hepatic triglyceride lipase].
The post-heparin plasma contains two lipolytic enzymes. This review deals with the lesser known, hepatic triglyceride lipase. Like lipoprotein lipase, H-TGL is a glycoprotein and has an optimal pH of 8-9. But it does not require an activator protein and its activity is not inhibited by NaCl or protamine sulfate. Synthesized by the hepatocytes, H-TGL is located at the hepatic vascular endothelium. It catalyses the hydrolysis of a wide variety of lipid substrates including triacylglycerol and phospholipids. The function of the enzyme is still not fully known. H-TGL may function in the clearance of triglyceride rich lipoprotein remnants and in the catabolism of HDL.
Laboratoire de Biochimie Médicale, CHU, Angers.
G
G
Simard
B
B
Perret
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004727:Endothelium / Q000166:cytology / Q000201:enzymology; D006801:Humans; D006868:Hydrolysis; D008049:Lipase / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008075:Lipoproteins, HDL / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D051381:Rats
D008075:Lipoproteins, HDL; D008049:Lipase
La triglycéride lipase hépatique.