Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.
A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
M
M
Oka
H
H
Kamei
Y
Y
Hamagishi
K
K
Tomita
T
T
Miyaki
M
M
Konishi
T
T
Oki
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002855:Chromatography, Thin Layer; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D012995:Solubility; D013053:Spectrophotometry; D013302:Streptomyces / Q000145:classification / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000627:therapeutic use*; D000095602:Angucyclines and Angucyclinones
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D014750:Vincristine; C066105:rubiginones; D000095602:Angucyclines and Angucyclinones