Age-specific prevalence of antibody to enterotoxigenic Escherichia coli in Ecuadorian and German children.
Serum samples from 1397 Ecuadorian children 0-5 years of age were tested by ELISA for antibodies to enterotoxigenic Escherichia coli (ETEC). A gradual prevalence and titer increase was seen for IgG antibodies to heat-labile enterotoxin in children 6-18 months old; 90% prevalences were reached in the second year of life. At this age less than 10% of West German children showed IgG antibodies to heat-labile enterotoxin. In Ecuador age-related ETEC-specific antibody titer increases correlated with age-related prevalence of diarrheal disease. On the other hand, pooled lipopolysaccharide from different ETEC-associated O serogroups could not be used as a seroepidemiologic marker of ETEC infections.
Brüssow
H
H
Nestlé Research Center, Nestec, Lausanne, Switzerland.
Sidoti
J
J
Link
H
H
Hoang
Y K
YK
Barclay
D
D
Dirren
H
H
Freire
W B
WB
D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000276:immunology; D003968:Diarrhea, Infantile / Q000453:epidemiology* / Q000276:immunology; D004484:Ecuador / Q000453:epidemiology; D004768:Enterotoxins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000276:immunology; D029968:Escherichia coli Proteins; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008070:Lipopolysaccharides / Q000276:immunology; D015995:Prevalence
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C027538:heat-labile enterotoxin, E coli