Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. II. Structure elucidation.
The structures of janthinocins A, B and C, three novel macrocyclic peptide lactone antibiotics isolated from fermentations of Janthinobacterium lividum, were determined. The janthinocins are of particular interest because they contain three amino acid residues that have not previously been reported in natural products: Each contains erythro-beta-hydroxy-D-leucine while janthinocins A and B also contain beta-hydroxytryptophan and beta-ketotryptophan, respectively.
Squibb Institute for Medical Research, Princeton, NJ 08543-4000.
J H
JH
Johnson
A A
AA
Tymiak
M S
MS
Bolgar
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry*; D023181:Antimicrobial Cationic Peptides; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis*; D010456:Peptides, Cyclic / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D010456:Peptides, Cyclic; C066083:janthinocin A; C066084:janthinocin B; C066085:janthinocin C