[Immunodiagnosis of immune thrombocytopenias and their clinical significance].
Immune thrombocytopenia remains a diagnosis per exclusionem. There are no specific clinical symptoms or laboratory parameters to ensure diagnosis. In otherwise caused thrombocytopenias many authors found increased platelet-associated immunoglobin (PaIg) and platelet-binding serum immunoglobulin (PbSIg). Methods to determine PaIg and PbSIg are described and their clinical relevance is discussed. Determinations of PaIg and PbSIg with Ig-L-chain-specific ELISA are recommended. They improve diagnostic possibilities to distinguish ITP from nonimmune thrombocytopenias.
Abteilung für Medizinische Immunologie, Medizinischen Akademie Erfurt.
F
F
Wietschel
K
K
Malberg
D000936:Antigen-Antibody Complex / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D012995:Solubility; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007136:Immunoglobulins
Immundiagnostik der Immunthrombozytopenien und ihre klinische Wertigkeit.