Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion.
The authors observed a pleiomorphic lymphoma mimicking Hodgkin's lymphoma in a French Guyana black woman lacking antibodies for human T-cell lymphoma/leukemia virus type I (HTLV I). After two courses of chemotherapy with either mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) or doxorubicin, bleomycin, vincaleukoblastine, and dacarbazine (ABVD), a typical acute T-cell leukemia/lymphoma developed with HTLV I seroconversion. Specific HTLV I DNA sequences were detected using the polymerase chain reaction (PCR) on a lymph node biopsy obtained before chemotherapy. The mechanisms of the seroconversion are discussed.
Department of Hematology, Hôpital Cochin, France.
F
F
Picard
F
F
Dreyfus
M
M
Le Guern
M
M
Tulliez
L
L
d'Auriol
S
S
Neron
F
F
Galibert
S
S
Saragosti
B
B
Varet
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D006689:Hodgkin Disease / Q000175:diagnosis*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D015703:Antigens, CD; D004279:DNA, Viral; D015481:HTLV-I Antibodies