Effects of unilateral intrahippocampal injection of MK-801 upon local cerebral glucose utilisation in conscious rats.
The effects of unilateral intrahippocampal injections of the non-competitive NMDA receptor antagonist, MK-801, on local cerebral glucose utilisation have been examined in conscious rats using [14C]2-deoxyglucose autoradiography. The intrahippocampal injection of MK-801 (10 nmol) induced significant marked increases in glucose use in the ipsilateral hippocampus molecular layer and dentate gyrus (by 31 and 44%, respectively). Function-related glucose use in brain regions with known neuronal connections with the site of drug administration (e.g. entorhinal cortex, septal nucleus, mamillary body) was minimally altered after intrahippocampal MK-801 administration. Blockade of hippocampal NMDA receptors does not appear to modify activity, as reflected in local glucose utilisation, in hippocampal afferent and efferent circuits in conscious rats.
Wellcome Surgical Institute, University of Glasgow, U.K.
A
A
Kurumaji
J
J
McCulloch
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000008:administration & dosage / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D007839:Functional Laterality; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003986:Dibenzocycloheptenes; D016291:Dizocilpine Maleate; D003847:Deoxyglucose