The analysis of hypervariable DNA profiles: problems associated with the objective determination of the probability of a match.
A computerised system has been used to store DNA profiles from 3 hypervariable loci. This initial survey illustrates that band matching is only possible after analysis of the errors associated with electrophoretic systems. A number of databases have been constructed with the three probes investigated and two methods of frequency determination, 'binning' and 'sliding window' fitting, have been compared.
Central Research and Support Establishment, Home Office Forensic Science Service, Reading, Berkshire, UK.
P
P
Gill
K
K
Sullivan
D J
DJ
Werrett
D001345:Autoradiography; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D003627:Data Interpretation, Statistical; D015252:Deoxyribonucleases, Type II Site-Specific; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005821:Genetic Techniques; D014644:Genetic Variation; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization
D004247:DNA; C024669:endodeoxyribonuclease AluI; D015252:Deoxyribonucleases, Type II Site-Specific