[Synthetic analgesic moradol at various stages of surgical treatment of patients with cancer].
Moradol ("Galenika", Yugoslavia)/butorphanol tartrate ("Bristol--Mayers C.", USA)/, a synthetic analgesic representing a new generation of opiate receptors agonists-antagonists, devoid of any narcogenic potential has been used as the only analgesic at all stages of anesthesia during cancer surgery in 26 patients. For premedication moradol was used in a mean dose of 0.032 +/- 0.003 mg.kg-1 in combination with diazepam (0.153 +/- 0.005 mg.kg-1) and atropine (0.01 mg X X kg-1). For induction to anesthesia moradol was used in a dose of 0.72 +/- 0.003 mg.kg-1 and diazepam in a dose of 0.27 +/- 0.015 mg.kg-1. General anesthesia was maintained with moradol, diazepam, nitrous oxide and droperidol. The data presented in the paper demonstrate the advantages of moradol at all stages of intra- and postoperative analgesia, which ensures stable anesthetic background (according to hemodynamic parameters) and reduces considerably an overall postoperative analgesic dose.
Osipova
N A
NA
Petrova
V V
VV
Novikov
G A
GA
Ziai
G R
GR
Mel'nikova
Z L
ZL
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D002077:Butorphanol / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000008:administration & dosage*; D009369:Neoplasms / Q000601:surgery*; D010149:Postoperative Pain / Q000188:drug therapy*; D011229:Preanesthetic Medication
D009019:Morphinans; D003975:Diazepam; D002077:Butorphanol
Sinteticheskiĭ analgetic moradol na étapakh khirurgicheskogo lecheniia onkologicheskikh bol'nykh.