Modulation of polyclonal activation of lymphocytes by cyclophosphazenic compounds bearing ethylene-imino groups and vectorized by polyamines.
Cyclophosphazenic compounds bearing ethylene-imino groups are cytocydal chemicals which can modulate polyclonal activation of lymphocytes (PAL) and prevent the development of murine lupus. The effects on PAL of the different parts of these chemicals and of vectorization by polyamines have been investigated by treating lipopolysaccharide injected C57Bl/6 mice with various cyclophosphazenic compounds and thiotepa. The immune effects of the cyclophosphazenic substances have been found to be mediated by ethylene-imino groups and to be modulated by polyamine vectorization. These compounds might represent a new class of drugs for treatment of immune mediated diseases of the lupus type.
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Laboratoire d'Immunopathologie Rénale et d'Immunopharmacologie, CJF INSERM 88.01, Faculté de Médecine PURPAN, Toulouse, France.
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Labarre
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Sournies
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Fournié
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GJ
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005030:Ethylenes / Q000494:pharmacology; D005260:Female; D007094:Imides / Q000494:pharmacology*; D007098:Imino Acids / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D001388:Aziridines; D005030:Ethylenes; D007094:Imides; D007098:Imino Acids; D009943:Organophosphorus Compounds; D011073:Polyamines