The effect of Plasmodium falciparum exo-antigens on the morphology of uninfected erythrocytes.
It was observed that uninfected red cells resuspended in supernatant from Plasmodium falciparum cultures, then examined between a glass slide and cover-slip, assumed varying morphologies. A series of experiments suggested that P. falciparum releases molecules which cause red cells to become stomatocytic (cupped). These molecules, some of which are heat-stable have an apparent molecular weight greater than 12 kDa, are released at or about schizogony, and do not bind tightly to erythrocytes.
Queensland Institute of Medical Research, Herston, Australia.
D G
DG
Read
G R
GR
Bushell
C
C
Kidson
D000818:Animals; D000953:Antigens, Protozoan / Q000502:physiology*; D004912:Erythrocytes / Q000166:cytology*; D010963:Plasmodium falciparum / Q000276:immunology*
D000953:Antigens, Protozoan