The effect of enalapril on leg muscle blood flow in patients with claudication.
In the percent study the authors have demonstrated that the peripheral blood flow and resistance as measured by strain-gauge venous occlusion plethysmography were favourably altered by enalapril. The peripheral blood flow increased significantly and since there was no detectable change in ankle pressure this indicated a decrease in resistance during administration of the drug.
Irvine Laboratory for Cardiovascular Investigation and Research, St Mary's Hospital Medical School, London, UK.
T N
TN
Sonecha
A N
AN
Nicolaides
P
P
Kyprianou
A
A
Zukowski
K
K
Papadakis
S
S
Vasdekis
A M
AM
Salmasi
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004656:Enalapril / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects
D004656:Enalapril