Operational aspects of bioreactor contamination control.
The contamination-free operation of a bioreactor demands constant attention to details. Assuming a well-designed and validated system exists, contamination control requires a skilled operating staff, clear and concise standard operating procedures, ongoing operations review and training, thorough cleaning of equipment, and an effective preventative maintenance program. This paper highlights basic operational aspects of contaminant-free bioreactor operation from inoculum development to bioreactor harvesting.
Perkowski
C A
CA
Stearns Catalytic Division, United Engineers & Constructors Inc., Philadelphia, Pennsylvania.
D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D004784:Environmental Monitoring / Q000592:standards*; D004866:Equipment Contamination / Q000517:prevention & control*; D007318:Inservice Training; D008283:Maintenance / Q000592:standards*; D008828:Microbiological Techniques / Q000295:instrumentation* / Q000592:standards
D003470:Culture Media