[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme].
The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level. 236 patients with malaria were examined and treated. 38% of them previously used antimalarials. The increase dosage in comparison with the WHO recommendations (25 mg/kg), lead to no advantages for chloroquine treatment (50% failure), in contrast with amodiaquine (4% failure). Therefore amodiaquine might be preferred in the health field unit for uncomplicated malaria.
Centre Pasteur.
C
C
Hengy
F
F
Eberlé
A
A
Arrive
D
D
Kouka-Bemba
P
P
Gazin
R
R
Jambou
D000655:Amodiaquine / Q000627:therapeutic use*; D000818:Animals; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*
D000655:Amodiaquine; D002738:Chloroquine
Accès palustres simples en zone de haut niveau de résistance à la chloroquine. 2. Evaluation de schémas thérapeutiques de première intention.