Cerebrospinal fluid neuropeptide Y in Alzheimer's disease.
The cerebrospinal fluid neuropeptide Y level was measured by radioimmunoassay in 20 patients with probable Alzheimer's disease and in 19 controls. The mean level was lower in patients (69.5 +/- 36.7 pg/ml) than in controls (103 +/- 21.8 pg/ml; p less than 0.001). Patients with a disease duration of greater than 2 years had cerebrospinal fluid neuropeptide Y levels lower than those with shorter disease duration (p less than 0.02). These results suggest that neuropeptide Y containing cells may be involved in Alzheimer's disease. No correlation was found between neuropeptide Y levels and degree of cognitive impairment or age at disease onset.
Department of Neurology, Hospital Clinic i Provincial, Faculty of Medicine, University of Barcelona, Spain.
J
J
Alom
R
R
Galard
R
R
Catalan
J M
JM
Castellanos
S
S
Schwartz
E
E
Tolosa
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000523:psychology; D000918:Antibody Specificity; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay
D007457:Iodine Radioisotopes; D009478:Neuropeptide Y