Cholestatic jaundice in the newborn.
Neonatal cholestasis or direct hyperbilirubinemia in the first 3 months of life is nearly always more pathologic than physiologic. This article reviews the extensive differential diagnosis of cholestatic jaundice and the approach to diagnosis. A sense of urgency is underscored by the value of early recognition and intervention in metabolic, iatrogenic, and anatomic disorders. The long-term management goals are reviewed, including indications for hepatic transplantation.
Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins Hospital, Baltimore, Maryland.
B A
BA
Haber
A M
AM
Lake
D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy