Primary cutaneous rhabdomyosarcoma.
We report an unusual case of primary cutaneous embryonal rhabdomyosarcoma presenting as a solitary skin lesion on the anterior chest of a 20-month-old child. The tumor was characterized by small, round to oval, poorly differentiated cells. Immunohistochemically, the tumor was negative for NSE, S-100 protein, LCA, and keratin but positive for muscle-specific actin, myoglobin, desmin, and vimentin, thus indicating the presence of myogenous differentiation. Ultrastructural analysis demonstrated thick and thin filaments. Special studies showed no evidence of a primary rhabdomyosarcoma in the patient at a more typical location, nor was there any evidence of metastases.
Chang
Y
Y
Department of Pathology, University of California, San Francisco Medical Center 94143.
Dehner
L P
LP
Egbert
B
B
D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure