Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.
The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.
D T
DT
Wong
R W
RW
Fuller
D W
DW
Robertson
D000818:Animals; D005473:Fluoxetine / Q000494:pharmacology*; D006801:Humans; D012702:Serotonin Antagonists; D013237:Stereoisomerism
D012702:Serotonin Antagonists; D005473:Fluoxetine