Positively charged residues are important determinants of membrane protein topology.
Membrane proteins are found in a variety of conformations, with each protein spanning the membrane a set number of times and adopting a particular orientation. Positively charged residues, often located near the boundaries of transmembrane segments, appear to be involved in specifying the topology of membrane proteins.
Department of Chemistry, Ohio State University, Columbus 43210.
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Dalbey
D002462:Cell Membrane / Q000648:ultrastructure; D004563:Electrochemistry; D004926:Escherichia coli; D005057:Eukaryotic Cells; D008565:Membrane Proteins / Q000378:metabolism / Q000648:ultrastructure*; D011487:Protein Conformation; D021382:Protein Sorting Signals
D008565:Membrane Proteins; D021382:Protein Sorting Signals