Serum magnesium concentrations after repetitive magnesium cathartic administration.
Severe hypermagnesemia has been reported by several authors after multiple doses of magnesium-containing cathartic are administered during management of a toxic ingestion. To evaluate the frequency and magnitude of serum magnesium elevations after the use of repetitive magnesium catharsis, we prospectively evaluated 102 patients who received multiple doses of magnesium citrate as a part of treatment of an overdose. Commonly ingested substances for which repetitive cathartic was administered were tricyclic antidepressants in 47%, aspirin in 17%, and phenytoin in 10%. For each case, serial electrolytes, blood urea nitrogen, creatinine, calcium and magnesium were obtained. Mean initial serum magnesium concentration was 1.8 +/- .03 mEq/L. After a mean 960 mL of magnesium citrate (9.22 g magnesium), final mean serum magnesium concentration was 2.5 +/- .05 mEq/L. Forty-seven patients (47%) developed an elevated (greater than 2.4 mEq/L) serum magnesium concentration, with 12 greater than 3.0 mEq/L. No correlation was found between total quantity of magnesium citrate administered and the increment in serum magnesium concentration. Our data indicate that serum magnesium concentrations consistently rise after repetitive magnesium citrate use. However, the magnitude of this rise appears modest. The elevation in serum magnesium concentration does not correlate with the quantity of magnesium administered. We conclude that with close monitoring, repetitive magnesium citrate can be administered without inducing severe hypermagnesemia (serum magnesium concentration greater than 5.0 mEq/L).
Massachusetts Poison Control System, Harvard Medical School, Boston 02115.
J A
JA
Woodard
M
M
Shannon
P G
PG
Lacouture
A
A
Woolf
D000293:Adolescent; D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D002400:Cathartics / Q000009:adverse effects*; D002606:Charcoal / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000628:therapy*
D002400:Cathartics; D002606:Charcoal; D008274:Magnesium