[Ropivacaine--a new local anesthetic with specific properties].
Ropivacaine is the (S)-enantiomer of 1-propyl-2',6'-pipecoloxylidide. In terms of its physicochemical properties, it is a long-acting local anesthetic (molecular weight of the base 274, pKa 8.07, protein-binding 92%). It shows a selective action on A delta and C fibers. This may be attributable to its relatively low partition coefficient (6.1 in n-heptane). The subcutaneous and intravenous acute toxicity (LD50) is lower than that of other long-acting local anesthetics. Because of its vasoconstrictor potency, its use as a vasoconstrictor-free solution is of particular interest.
Anaesthesie-Abteilung St. Marienkrankenhaus, Ludwigshafen/Rhein.
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Niesel
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Kaiser
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Eilingsfeld
D000577:Amides / Q000633:toxicity; D000779:Anesthetics, Local / Q000633:toxicity; D000818:Animals; D006801:Humans; D000077212:Ropivacaine; D014662:Vasoconstrictor Agents
D000577:Amides; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D000077212:Ropivacaine
Ropivacain--ein neues Lokalanaesthetikum mit spezifischen Eigenschaften.