[Effects of tetrandrine on platelet aggregation, platelet adhesion and coagulation].
We examined the effect of tetrandrine on platelet aggregation, platelet adhesion and coagulation in vitro. The results showed that tetrandrine markedly inhibited the platelet aggregation induced by ADP or collagen. Tetrandrine also markedly inhibited platelet adhesion and thrombosis, but didn't change thrombin coagulation time and plasma coagulation time obviously.
Hebei Academy of Medical Sciences, Shijiazhuang.
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Wu
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Zhao
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Qi
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013918:Thrombin Time
D000470:Alkaloids; D044182:Benzylisoquinolines; C009438:tetrandrine