[Study of the conditions for reproducing the processes of antibiotic biosynthesis. Calculating the process of sisomycin biosynthesis].
Conditions were experimentally studied for reproducing sisomicin biosynthesis by up-to-down scaling. It was shown that respiration intensity as a parameter of antibiotic biosynthesis scaling-down had certain limitations connected with multistage oxygen mass transfer. The parameter could be used only when the limiting stages of oxygen mass transfer coincided. It was confirmed experimentally that it was possible to apply the previously proposed theoretical method to estimation of the limiting stage of oxygen mass transfer.
Kuz'mina
L M
LM
Biriukov
V V
VV
D000388:Air; D001431:Bacteriological Techniques / Q000295:instrumentation*; D003470:Culture Media; D005285:Fermentation; D066298:In Vitro Techniques; D007218:Industrial Microbiology / Q000295:instrumentation / Q000379:methods*; D008433:Mathematics; D008847:Micromonospora / Q000378:metabolism*; D008954:Models, Biological; D010100:Oxygen / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D012853:Sisomicin / Q000096:biosynthesis*
D003470:Culture Media; D010100:Oxygen; D012853:Sisomicin
Issledovanie usloviĭ vosproizvodimosti protsessov biosinteza antibiotikov. Masshtabirovanie protsessa biosinteza sizomitsina.