Amphotericin B O-methyl oxime. Synthesis and biological properties.
Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity.
Czerwiński
A
A
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
König
W A
WA
Sowiński
P
P
Falkowski
L
L
Mazerski
J
J
Borowski
E
E
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects
C066130:amphotericin B O-methyloxime; D000666:Amphotericin B