[The effect of insulin on lethality in mice with acute ethanol poisoning].
Intraperitoneal injection of 25% ethanol solution in LD80 doses caused death of approximately 60% of satiated and starving animals in the first 60 minutes. The death peak was encountered 3-10 minutes after the injection of ethanol and corresponded with the peak of its concentration in the blood. The early death of the animals was connected with arrest of respiration in inhibition of cardiac activity. A tendency towards increase of ethanol LD50 60 minutes after its injection in administration of insulin was encountered. The changes of ethanol LD50 were statistically insignificant.
E V
EV
Savitskaia
V P
VP
Listvina
I G
IG
Zabirova
D000435:Alcoholic Intoxication / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000097:blood / Q000633:toxicity; D005215:Fasting; D005947:Glucose / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol; D005947:Glucose
Vliianie insulina na letal'nost' mysheĭ pri ostroĭ intoksikatsii étanolom.