Changes in indocyanine green kinetics after the administration of enalapril to healthy subjects.
Enalapril maleate, an angiotensin converting enzyme inhibitor, is a vasodilator liable to modify regional blood flow. The effects of an oral dose of 40 mg enalapril maleate on indocyanine green (ICG) kinetics were assessed in nine healthy subjects. At 4 h after the administration of the drug, a 35% decrease in ICG clearance was observed (P less than 0.01) associated with a 23% decrease in its volume of distribution (P less than 0.02). The half-life of ICG was not altered significantly by enalapril. These results suggest that the administration of enalapril maleate to healthy subjects may reduce apparent liver plasma flow and plasma volume, as a consequence of the pooling of blood in the hepatosplanchnic area.
Clinique Thérapeutique, Hôpital Lariboisiere, Paris, France.
J
J
Geneve
T
T
Le Dinh
A
A
Brouard
M
M
Bails
J M
JM
Segrestaa
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C
Caulin
D000328:Adult; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male
D004656:Enalapril; D007208:Indocyanine Green