[Monapterin and biopterin in degenerated retinas].
We measured the concentrations of biopterin, neopterin and monapterin in the neuroretina of humans and different rat strains and found a relatively high amount of oxidized monapterin in these tissues. The dystrophic retinae of RCS rats revealed an inverse ratio of biopterin-to-monapterin compared to LE rats. This ratio was altered in LE rats after exposure to strong light. These results suggest that changes in pterin metabolism may correlate with retinal dystrophy.
Universitäts-Augenklinik, Münster.
K
K
Krause
G
G
Cremer-Bartels
H
H
Gerding
L
L
Hanneken
D000818:Animals; D001708:Biopterins / Q000032:analysis; D006801:Humans; D011622:Pterins / Q000032:analysis*; D011832:Radiation Injuries / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000737:chemistry* / Q000528:radiation effects; D012162:Retinal Degeneration / Q000378:metabolism*
D011622:Pterins; D001708:Biopterins
Monapterin und Biopterin in degenerierten Netzhäuten.