A laser Doppler velocimetry study of the effect of hypoglycaemia on retinal blood flow in the minipig.
The effect of acute hypoglycaemia (plasma glucose less than 2.2 mmol/l) on retinal venous blood flow in the minipig has been determined using bidirectional laser Doppler velocimetry and red free retinal photography. In six pigs the mean flow in a retinal vein increased from 19.3 (+/- 2.8 SEM) microliters/min to 29.7 (+/- 7.5) microliters/min during hypoglycaemia (p less than 0.05) with a return to 18.6 (+/- 3.6) microliters/min when euglycaemia was restored. Retinal blood flow is affected by hypoglycaemia or its haemodynamic consequences.
Department of Medicine, Royal Postgraduate Medical School, London, UK.
G
G
Caldwell
E G
EG
Davies
P M
PM
Sullivan
A H
AH
Morris
E M
EM
Kohner
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015309:Glucose Clamp Technique; D007003:Hypoglycemia / Q000503:physiopathology*; D007429:Intraocular Pressure; D007834:Lasers; D011674:Pulse; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000503:physiopathology*; D013552:Swine; D013556:Swine, Miniature; D014465:Ultrasonics
D001786:Blood Glucose