Plasma renin activity in fetal disease.
Fetal plasma renin activity (PRA) was measured in 42 pregnancies. Compared to control fetuses, PRA was elevated in three of four hypoxemic fetuses, in two of five with hydrops and in two of five with uropathies. PRA did not change with transfusion in seven alloimmunized fetuses. This study demonstrates PRA in human fetuses and suggests that the renin-angiotensin system can respond to stimuli in fetal life.
Fetal Medicine Unit, Queen Charlotte's and Chelsea Hospital, London, U.K.
Y
Y
Tannirandorn
N M
NM
Fisk
V
V
Shah
M J
MJ
Dillon
U
U
Nicolini
C H
CH
Rodeck
D005315:Fetal Diseases / Q000097:blood* / Q000503:physiopathology; D005333:Fetus / Q000378:metabolism; D006801:Humans; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System
D012083:Renin