Commercial double-indicator-dilution densitometer using heavy water: evaluation in oleic-acid pulmonary edema.
We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L.min.m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.
Department of Anesthesia, University of Pennsylvania School of Medicine, Philadelphia.
L G
LG
Leksell
M S
MS
Schreiner
A
A
Sylvestro
G R
GR
Neufeld
D000818:Animals; D004396:Coloring Agents; D003720:Densitometry / Q000295:instrumentation / Q000379:methods*; D003903:Deuterium; D015633:Extravascular Lung Water / Q000032:analysis*; D006041:Goats; D006358:Hot Temperature; D007201:Indicator Dilution Techniques; D007208:Indocyanine Green; D009829:Oleic Acids; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism*
D004396:Coloring Agents; D009829:Oleic Acids; D003903:Deuterium; D007208:Indocyanine Green