Retrospectives and perspectives on the biological activity of histidine-containing dipeptides.
1. An evaluation of the biological function of histidine-containing dipeptides, is presented. 2. These have been found to be potent pH-buffering compounds, strong antioxidants and membrane stabilizers. 3. Analysis of the biological and biomedical properties of carnosine and other related dipeptides suggests their use as universal membrane repairing compounds.
Department of Biochemistry, Moscow State University, U.S.S.R.
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Boldyrev
D000818:Animals; D002021:Buffers; D002336:Carnosine / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D006639:Histidine; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D014714:Vertebrates
D002021:Buffers; D004151:Dipeptides; D006639:Histidine; D002336:Carnosine