Experience in rat pancreas transplantation at Meikai University.
A review of rat pancreatic transplantation conducted at Meikai University is presented. It was found that pancreas transplantation normalized the endocrine based metabolic disturbances of diabetes. Arginine-induced serum insulin, glucagon, and somatostatin responses in the grafted pancreas were similar to those in normal pancreas. Urine amylase was found to be a more sensitive marker in graft rejection as compared with blood glucose using a urinary drainage model. The value of pancreas transplantation in diabetic nephropathy was dependent upon the timing of the transplantation; performed early in the course of diabetes (less than 4 months, post-diabetes), it was able to reverse the nephropathy.
Nozawa
M
M
Department of Surgery, Meikai University, Saitama, Japan.
Otsu
I
I
D000818:Animals; D003921:Diabetes Mellitus, Experimental; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000503:physiopathology; D008297:Male; D010179:Pancreas / Q000503:physiopathology; D016035:Pancreas Transplantation / Q000379:methods; D051381:Rats; D011917:Rats, Inbred Lew; D001743:Urinary Bladder / Q000503:physiopathology