Premature centromere division of a translocation-carrier autosome.
Premature centromere division of an aberrant chromosome 3 was found in a newborn girl with fetal hydrops and in her healthy father, both bearing a familial "balanced" 3p;19q translocation. The out-of-phase separation of a structurally abnormal chromosome may be of pathogenetic significance, the nature of which is not yet understood.
Méhes
K
K
Department of Paediatrics, University Medical School of Pécs, Hungary.
Kosztolányi
G
G
D000328:Adult; D002503:Centromere / Q000473:pathology*; D002875:Chromosomes; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D006831:Polyhydramnios; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014178:Translocation, Genetic