Seroepidemiologic evaluation of anti-toxic and anti-colonization factor immunity against infections by LT-producing Escherichia coli in rural Bangladesh.
To evaluate serologic immunity against clinical infections by heat-labile enterotoxin-producing Escherichia coli (LT-ETEC) in rural Bangladesh, 124 children and adult women with LT-ETEC diarrhea (cases) were compared with 347 age-matched community controls. In paired acute-convalescent sera from the cases, IgG anti-CFA I and anti-CFA II antibody titers increased eight-to ninefold after infection by LT-ETEC with the homologous CFA, and IgG anti-LT antibody titers increased fourfold for all LT-ETEC infections. Anti-CFA and anti-LT titers peaked in controls aged 12-23 months, the age group with the highest incidence of ETEC infections. However, antibody titers were similar in acute sera from cases and in sera from controls. Although serum IgG anti-CFA and anti-LT antibodies rose in response to LT-ETEC infections and paralleled the age-specific incidence of ETEC in the community, these antibodies were not associated with a lower risk of LT-ETEC diarrhea.
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
J D
JD
Clemens
A M
AM
Svennerholm
J R
JR
Harris
S
S
Huda
M
M
Rao
P K
PK
Neogy
M R
MR
Khan
M
M
Ansaruzzaman
S
S
Rahaman
F
F
Ahmed
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000276:immunology*; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000276:immunology*; D001459:Bangladesh / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000276:immunology*; D004768:Enterotoxins / Q000096:biosynthesis / Q000276:immunology*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000276:immunology*; D029968:Escherichia coli Proteins; D005260:Female; D036781:Fimbriae Proteins; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D012424:Rural Population
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D007074:Immunoglobulin G; C022924:colonization factor antigens; D036781:Fimbriae Proteins; C027538:heat-labile enterotoxin, E coli