[The clinical importance of magnesium. 2. The indications for supplementation and therapy].
Mg deficiency is characterized by diverse secondary electrolyte alterations. Extracellularly, hypocalcemia is a particular feature, which may be explained by increased resistance of bone towards parathormone. Intracellularly, decreased concentrations of Mg and K and increased amounts of Na and Ca are found in contractile organelles. At increased Mg levels, concentration of parathormone may decrease, leading to hypocalcemia. Calcium-antagonistic effects are observed in smooth muscle, the myocardium and the end-plate of skeletal muscles. Hence, Mg may be prescribed either to correct a deficit or to utilize its pharmacologic effects. Dosaging still needs to be optimized.
Institut für Biologische Chemie und Ernährungs wissenschaft der Universität Stuttgart-Hohenheim.
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D002118:Calcium / Q000037:antagonists & inhibitors; D004573:Electrolytes / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000188:drug therapy* / Q000378:metabolism
D004573:Electrolytes; D008274:Magnesium; D002118:Calcium
Die klinische Bedeutung von Magnesium. Teil 2: Indikationen zur Supplementation und Therapie.