[Amiodarone and thyroid: the Janus effect].
Iodide released from Amiodarone during a chronic treatment is 100 x higher than food iodide intake. Thyroid adaptation allows normal function but over-adaptation leads to hypothyroidism and hypo-adaptation to thyrotoxicosis. Thyrotoxicosis may also result from follicular disruption. Amiodarone inhibits 5' deiodinase type I and II and hence increases serum T4 and (transiently) TSH and decreases serum T3 concentrations. Perchlorate and corticoids may be useful in the treatment of thyrotoxicosis.
Service d'Endocrinologie, Clinique Universitaires de Bruxelles, Hôpital Erasme, U.L.B.
J
J
Unger
D000222:Adaptation, Physiological; D000638:Amiodarone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007455:Iodine / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism
D013963:Thyroid Hormones; D007455:Iodine; D000638:Amiodarone
Amiodarone et thyroïde: l'effet Janus.