[Serum theophylline concentrations in patients with chronic obstructive lung diseases: a comparison of 2 methods].
A total of 120 samples of serum were obtained from 8 patients with COPD and submitted to a comparative analysis of serum theophylline levels employing the TDX and the EMIT methods of determination. At the same time, two different slow-release preparations of theophylline were compared, their kinetics investigated, and their effects tested using body plethysmography. For this open, randomized cross-over preliminary investigation, numerous inclusion and exclusion criteria were applied.
Innere Abteilung und Zentrallaboratorium des Marienhospitals, Gelsenkirchen.
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Voshaar
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Schweisfurth
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Schöttes
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Prinsen
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Koch
D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D005454:Fluorescence Polarization; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D008173:Lung Diseases, Obstructive / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013806:Theophylline
Serumtheophyllinkonzentrationen bei Patienten mit chronisch obstruktiven Lungenerkrankungen: Ein Vergleich zweier Methoden.