Induction of haem oxygenase as a defence against oxidative stress.
Cells respond to metabolic perturbations by producing specific stress proteins. Exposure of mammalian cells to various forms of oxidative stress induces haem oxygenase, the rate-limiting enzyme in haem degradation. This response is proposed to represent an antioxidant defence operating at two different stages simultaneously. It (i) decreases the levels of the potential pro-oxidants haem and haem proteins such as cytochrome P-450 and protoporphyrinogen oxidase, and (ii) increases the tissue concentrations of antioxidatively active bile pigments.
Stocker
R
R
Heart Research Institute, Camperdown NSW, Australia.
D000818:Animals; D000975:Antioxidants; D004790:Enzyme Induction; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D006706:Homeostasis; D006801:Humans; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D000975:Antioxidants; D006899:Mixed Function Oxygenases; D006419:Heme Oxygenase (Decyclizing); D010100:Oxygen