[Detection of the anti-cancer biological effect of naphthoquinone pigment-LIII].
Naphthoquinone pigment-LIII, an extract from Arnebia euchroma, could apparently inhibit the proliferation of stomach cancer cell line and esophagus cancer cell line. At the effective concentration of 5 micrograms/ml, the mitotic index and growth curve declined without showing any damage to human normal cells. At 5-10 micrograms/ml, the colony efficiency of cancer cells became significantly low. The anti-cancer effect of Naphthoquinone pigment-LIII might be related to its role of influencing the amount of RNA and ultrastructure of cancer cells which was discussed in this paper.
Beijing Institute for Cancer Research.
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Liao
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D009285:Naphthoquinones / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; C016101:shikonin