Influence of cisapride on food-stimulated gastro-oesophageal reflux: a radiological study.
The influence of Cisapride on food-stimulated gastro-oesophageal reflux mechanisms was studied in a double-blind cross-over investigation in 24 consecutive patients selected by endoscopy, 12 with microscopical evidence of gastro-oesophageal reflux and 12 with additional macroscopic oesophagitis. 63% had food-stimulated gastro-oesophageal reflux, and Cisapride significantly reduced the tendency to gastro-oesophageal reflux and mucosal contact time between gastric content and the oesophageal mucosa in 73% of these patients. It is concluded that Cisapride could be valuable in the treatment of gastro-oesophageal reflux.
Department of Radiology and Gastroenterology, Aarhus Kommunehospital, University of Aarhus.
J
J
Gelineck
K
K
Aksglade
P
P
Funch-Jensen
P
P
Thommesen
D000328:Adult; D000368:Aged; D001466:Barium Sulfate; D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004942:Esophagitis, Peptic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011859:Radiography; D012702:Serotonin Antagonists
D010880:Piperidines; D012702:Serotonin Antagonists; D001466:Barium Sulfate; D020117:Cisapride