Production of yeast killer toxin in experimentally infected animals.
The ability of a killer yeast (Pichia anomala, UCSC 25F) to produce toxin in vivo was demonstrated, for the first time, in tissues of normal and immunosuppressed experimentally infected mice by means of a fluorescent antibody technique and a killer toxin specific monoclonal antibody. The possible significance of the findings is discussed.
Polonelli
L
L
Istituto di Microbiologia, Università degli Studi di Parma, Italy.
Conti
S
S
Gerloni
M
M
Campani
L
L
Mantovani
M P
MP
Morace
G
G
D000818:Animals; D005455:Fluorescent Antibody Technique; D005656:Fungal Proteins / Q000032:analysis / Q000096:biosynthesis*; D007668:Kidney / Q000032:analysis / Q000382:microbiology; D055646:Killer Factors, Yeast; D008099:Liver / Q000032:analysis / Q000382:microbiology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000382:microbiology*; D009183:Mycotoxins / Q000032:analysis / Q000096:biosynthesis*; D010843:Pichia / Q000378:metabolism*; D004718:Saccharomycetales / Q000378:metabolism*; D013154:Spleen / Q000032:analysis / Q000382:microbiology
D005656:Fungal Proteins; D055646:Killer Factors, Yeast; D009183:Mycotoxins