Efficient means of studying ancillary questions in clinical trials.
Ancillary questions in clinical trials can often be answered by studying subcohorts of the participants. If the question compares responses between treatment groups, a subcohort that preserves the randomization can be used. However, if the question can be answered by analysis within a treatment group or by combining treatment groups, efficient methods developed for observational studies can be used. These methods include case-control and case-cohort methods.
Department of Biostatistics, University of North Carolina, Chapel Hill 27599-7400.
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D016022:Case-Control Studies; D015331:Cohort Studies; D004526:Efficiency; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000191:economics / Q000379:methods*; D012107:Research Design; D012494:Sampling Studies; D013223:Statistics as Topic