Histamine receptors: subclasses and specific ligands.
In this review the three main types of histamine receptors are discussed together with their specific ligands. For the classical H1-receptors much emphasis is put on the mechanism by which the receptor is stimulated. For the H1- and H2-receptor the review includes information on the several models available for establishing agonistic or antagonistic activity. In the section on the H3-receptor the ligands are discussed as well as the possible physiological role of this receptor. In the final paragraphs some less well defined activities are presented.
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
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Haaksma
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Leurs
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Timmerman
D000818:Animals; D006801:Humans; D008024:Ligands; D011968:Receptors, Histamine / Q000145:classification / Q000378:metabolism / Q000502:physiology
D008024:Ligands; D011968:Receptors, Histamine