Antimycotic effects of octenidine and pirtenidine.
The effects of octenidine and pirtenidine on yeasts (in particular Candida albicans) have been studied. MIC and MCC values have been established as well as the inhibitory effects on growth, budding and germ tube formation. The drugs were shown to cause extensive leakage of cytoplasmic contents from the cells which was correlated with morphological and ultrastructural changes in the yeast.
Department of Botany and Microbiology, Kuwait University.
M A
MA
Ghannoum
K A
KA
Elteen
M
M
Ellabib
P A
PA
Whittaker
D000631:Aminopyridines / Q000494:pharmacology*; D000935:Antifungal Agents; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D007097:Imines; D008826:Microbial Sensitivity Tests; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011725:Pyridines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development
D000631:Aminopyridines; D000935:Antifungal Agents; D007097:Imines; D011725:Pyridines; C034213:octenidine; C062638:pirtenidine