Sertraline in obsessive-compulsive disorder: a double-blind comparison with placebo.
Many agents that affect the brain's serotonergic system appear to be at least partially effective in the treatment of patients with obsessive-compulsive disorder. However, in this 10-week double-blind trial in which 10 patients received sertraline and nine received placebo, sertraline was ineffective according to four measures of obsessive-compulsive symptoms. The authors discuss the implications of these preliminary findings for the serotonergic theory of obsessive-compulsive disorder and the need to explore the role of other neurochemical systems in this disorder.
Obsessive-Compulsive Disorders Clinic and Research Unit, Massachusetts General Hospital, Boston 02114.
M A
MA
Jenike
L
L
Baer
P
P
Summergrad
W E
WE
Minichiello
A
A
Holland
R
R
Seymour
D015057:1-Naphthylamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D010919:Placebos; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D020280:Sertraline
D009281:Naphthalenes; D010919:Placebos; D012702:Serotonin Antagonists; D012701:Serotonin; D015057:1-Naphthylamine; D020280:Sertraline