[New aspects of the pathogenesis and therapy of Guillain-Barré syndrome and chronic polyneuritis].
The Guillain-Barré syndrome and chronic idiopathic polyradiculoneuropathy (CIDP) are examples of immune-mediated neuropathies. In the Guillain-Barré syndrome, antibodies directed to neutral glycolipids of peripheral nerve myelin have been detected that activate the complement system. There is evidence for the presence of circulating activated T lymphocytes. Humoral factors have been implicated in the pathogenesis of CIDP. The animal model experimental autoimmune neuritis lends itself to the elucidation of pathogenic immune mechanisms. The principal treatment is plasmapheresis. Further approaches to the therapy of the Guillain-Barré syndrome and CIDP are discussed.
Neurologische Klinik der Heinrich-Heine-Universität Düsseldorf.
H P
HP
Hartung
K
K
Heininger
K V
KV
Toyka
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology; D010956:Plasmapheresis; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000628:therapy
D001323:Autoantibodies; D009185:Myelin Proteins
Neue Aspekte zur Pathogenese und Therapie des Guillain-Barré-Syndroms und der chronischen Polyneuritis.