Effect of captopril on plasma prolactin in patients with essential hypertension.
The effects of the angiotensin-converting enzyme inhibitor captopril on blood pressure, heart rate, plasma prolactin, and renin activity were examined in a single-blind, placebo-controlled trial on 30 patients with essential hypertension (15 given drug, 15 placebo). Captopril, 25 mg administered orally, reduced the blood pressure and increased the plasma renin activity. Captopril decreased mean plasma prolactin from 17.5 +/- 1.4 ng/mL to 9.1 +/- 1.0 ng/mL (p less than 0.001). Significant correlation was found between captopril-induced change from control values of plasma prolactin (delta plasma prolactin) vs delta plasma renin activity (r = -0.688, p less than 0.001). These results suggest that acute administration of captopril was accompanied by a reduction in plasma prolactin and that this reduction may be of clinical significance during therapy of hypertension.
Saito
I
I
Center for Physical Education and Medicine, Keio, Japan.
Takeshita
E
E
Hayashi
S
S
Takenaka
T
T
Murakami
M
M
Saruta
T
T
Nagano
S
S
Sekihara
T
T
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011388:Prolactin / Q000097:blood*; D012083:Renin / Q000097:blood; D016037:Single-Blind Method
D011388:Prolactin; D002216:Captopril; D012083:Renin