Effect of captopril on oxyphenbutazone and ethanol-induced gastric lesions in rats.
We studied the effect of the angiotensin converting enzyme inhibitor, captopril, on two models of gastric ulcers; oxyphenbutazone and ethanol-induced lesions. There was a significant protective effect against oxyphenbutazone-induced ulcers, which was prevented by prior administration of indomethacin. Captopril, however, failed to protect against ethanol-induced lesions. These findings are discussed in the light of captopril being a sulfhydryl compound with prostaglandin-releasing activity.
Department of Pharmacology, Goa Medical College, Bambolim, India.
S A
SA
Bhounsule
J S
JS
Pereira
S S
SS
Hede
R S
RS
Diniz D'Souza
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D000431:Ethanol; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010113:Oxyphenbutazone; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000431:Ethanol; D002216:Captopril; D010113:Oxyphenbutazone; D007213:Indomethacin