Pathophysiology of cytokines.
Beside their therapeutic effects, cytokines are involved in pathologies such as IL-6 in myeloma tumor growth and bone resorption, BCGF in the proliferation of hairy cell leukemic cells, IL-2 in the capillary leak syndrome. For biotherapy to develop, it is necessary to understand both the beneficial and the deletorious effects of cytokines.
INSERM Unité 255, Institut Curie, Paris, France.
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Fridman
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Michon
D001172:Arthritis, Rheumatoid / Q000503:physiopathology; D001685:Biological Factors / Q000009:adverse effects / Q000502:physiology*; D002199:Capillary Permeability; D003115:Colony-Stimulating Factors / Q000502:physiology; D016207:Cytokines; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007376:Interleukin-2 / Q000009:adverse effects; D015850:Interleukin-6 / Q000502:physiology; D007938:Leukemia / Q000503:physiopathology; D009101:Multiple Myeloma / Q000503:physiopathology
D001685:Biological Factors; D003115:Colony-Stimulating Factors; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6