The analysis of hypervariable DNA profiles: problems associated with the objective determination of the probability of a match.
A computerised system has been used to store DNA profiles from 3 hypervariable loci. This initial survey illustrates that band matching is only possible after analysis of the errors associated with electrophoretic systems. A number of databases have been constructed with the three probes investigated and two methods of frequency determination, 'binning' and 'sliding window' fitting, have been compared.
Gill
P
P
Central Research and Support Establishment, Home Office Forensic Science Service, Reading, Berkshire, UK.
Sullivan
K
K
Werrett
D J
DJ
D001345:Autoradiography; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D003627:Data Interpretation, Statistical; D015252:Deoxyribonucleases, Type II Site-Specific; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D005821:Genetic Techniques; D014644:Genetic Variation; D006801:Humans; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization
D004247:DNA; C024669:endodeoxyribonuclease AluI; D015252:Deoxyribonucleases, Type II Site-Specific