Studies on cardiotonic agents. I. Synthesis of some quinazoline derivatives.
A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in anesthetized dogs. Among them, several 6,7-dimethoxyquinazoline derivatives showed potent cardiotonic activity.
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
Y
Y
Nomoto
H
H
Obase
H
H
Takai
T
T
Hirata
M
M
Teranishi
J
J
Nakamura
K
K
Kubo
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005260:Female; D008297:Male; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology
D002316:Cardiotonic Agents; D011799:Quinazolines