Loss of LH-RH neurons in the rostral forebrain of old female C57BL/6J mice.
This study reports the quantitative immunohistochemical distribution of luteinizing hormone-releasing hormone (LH-RH) neurons within the rostral forebrain of young (5-6 month) and old (26-28 month) C57BL/6J mouse. Old mice demonstrated a significant (18%) loss of LH-RH-containing neurons (p less than 0.001, ANOVA). The most striking losses involved the preoptic area (24%) and more rostral regions (26%). The presence of pituitary or mesenteric tumors in older mice did not affect the density of LH-RH neurons. These observations indicate that LH-RH neurons comprise part of the neuronal population previously reported to be reduced in the preoptic area of older mice (4).
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
M M
MM
Miller
D
D
Joshi
R B
RB
Billiar
J F
JF
Nelson
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL
D007987:Gonadotropin-Releasing Hormone