[Treatment of peptic ulcer hemorrhage with leucine enkephalin analog dalargin].
The article discusses treatment of 72 patients suffering from duodenal ulcer complicated by bleeding with the Soviet-made preparation Dalargin which is a synthetic analogue of leucine-enkephalin. The preparation was infused intravenously in a dose of 3 mg in physiological solution once daily. No other additional antiulcerative agents were give. The diagnosis was established on the basis of endoscopy. Dalargin led to cicatrization of the ulcers in 20.3 days in 60% of patient, obvious positive dynamics was noted in 32% of patients; in 8% of patients Dalargin proved ineffective. Basal hydrochloric acid secretion reduced by 56% during treatment.
Georgadze
A K
AK
Fomin
V B
VB
Bulgakov
S A
SA
Fedenko
V V
VV
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000150:complications* / Q000188:drug therapy; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Lechenie iazvennykh gastroduodenal'nykh krovotechenii s primeneniem analoga leĭtsin--enkefalina-dalargina.