Class II alloantigen induced on corneal endothelium. Role in corneal allograft rejection.
The expression of Class II major histocompatibility complex (MHC) antigens on corneal cells can be increased in vitro by (gamma-interferon) and in vivo in inflammatory reactions. The expression of Class II MHC by corneal endothelium of New Zealand White (NZW) rabbits during the rejection of corneal allografts was demonstrated by immunoperoxidase staining. Class II MHC expression by corneal endothelial cells may facilitate rejection of corneal allografts.
Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
J J
JJ
Donnelly
S E
SE
Orlin
Z G
ZG
Wei
I M
IM
Raber
J H
JH
Rockey
D000818:Animals; D000911:Antibodies, Monoclonal; D016039:Corneal Transplantation / Q000276:immunology*; D004728:Endothelium, Corneal / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D007124:Immunoenzyme Techniques; D007519:Isoantigens / Q000096:biosynthesis / Q000276:immunology*; D011817:Rabbits
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007519:Isoantigens