[Undesirable side effects of contrast media during i.v. DSA--a comparison of 2 nonionic contrast media].
For the first time a controlled double-blind study was performed to compare side effects and complications of i.v. DSA with central venous application of iopamidol and iopromide. 200 consecutive patients 15-85 years of age were studied. The randomisation brought up two homogeneously structured groups of 100 patients each. Using a given protocol, 66% of the patients were classified as high-risk patients. Side-effects and complications were registered by an extensive, standardised protocol. In 71 (35.5%) of 200 patients contrast-media related side effects and complications were noted. 37 reactions in 24 patients (9 iopamidol, 15 iopromide group) were classified as clinically relevant. In four patients (4%) of each group a drug therapy was initiated. Contrast-media related reactions occurred with delay in 5.5% of initially symptom-free patients. In no case intensive care or hospital admission became necessary. There were no significant differences between the two non-ionic contrast media in the incidence of side effects and complications. Both substances were well tolerated in i.v. DSA. In the total population patients with diseases known as auto-immune diseases and prior drug reactions demonstrated clinically relevant reactions significantly more often.
Gross-Fengels
W
W
Institut und Poliklinik für Radiologische Diagnostik, Universität zu Köln.
Neufang
K F
KF
Siebert
C
C
Lanfermann
H
H
Steinbrich
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide; D007479:Iopamidol
Unerwünschte Kontrastmittelnebenwirkungen bei der i.v. DSA--Vergleich von zwei nicht-ionischen Kontrastmitteln.