Insulin administration reverses the metabolic and electrocardiographic changes in acute myocarditis induced by Indian red scorpion (Buthus tamulus) venom in experimental dogs.
Acute myocarditis was produced by injection of 4 mg/kg Indian red scorpion (Buthus tamulus) venom in dogs. Several rhythm changes, conduction defects, infarction-like pattern and many other ECG abnormalities; hyperglycemia, reduced insulin secretion, rise in free fatty acids along with fall in triglycerides; depletion of glycogen content of atria, ventricles, liver and skeletal muscles was noticed within 20-30 minutes after scorpion envenomation. Ten units of crystalline insulin was given i.v. at this time. All the arrhythmias, conduction defects and other ECG abnormalities disappeared after intervention with insulin. The sinus rhythm persisted for a duration of 120 minutes till the animals were sacrificed. Reduction in free fatty acids along with a rise in triglycerides; glycogenesis in liver, cardiac and skeletal muscles was observed at the time when ECG tracing was normal. It is suggested that catecholamines released during autonomic storm in scorpion poisoning suppress insulin secretion. These in turn result in glycogenolysis; lipolysis resulting in increased free fatty acids and produce arrhythmias. Insulin administration results in glycogenesis; lipogenesis and stops arrhythmias.
Murthy
R R
RR
Lokmanya Tilak Municipal Medical College, Bombay, India.
Vakil
A E
AE
Yeolekar
K E
KE
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D007328:Insulin / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012604:Scorpion Venoms / Q000037:antagonists & inhibitors*
D007328:Insulin; D012604:Scorpion Venoms