Survival analysis techniques in angina pectoris trials.
The variable 'walking time to moderate angina' on an exercise stress test is the primary means to judge the efficacy of new treatments for angina pectoris. Unfortunately, 'walking time to moderate angina' is often censored by fatigue or other reasons for premature termination of the exercise stress test. If time to fatigue is not treatment-dependent, we propose use of survival analysis techniques in such trials. We present an example from a placebo-controlled multicentre clinical trial and results of simulations that compare various methods of analysis.
Bristol
D R
DR
Development Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901.
Castellana
J V
JV
D000704:Analysis of Variance; D000787:Angina Pectoris / Q000188:drug therapy / Q000401:mortality*; D003198:Computer Simulation; D005080:Exercise Test; D006801:Humans; D015233:Models, Statistical; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012044:Regression Analysis; D013223:Statistics as Topic; D016019:Survival Analysis