[Expression of HLA-class II antigens in malignant melanoma].
Sixteen primary and ten metastatic melanoma lesions were stained in indirect immunoperoxidase with HLA-DR, DP and DQ monoclonal antibodies. In primary lesions, HLA-DR, DQ and DP antigens were much more expressed in nodular melanoma lesions than in acral lentiginous melanoma lesions. In metastatic lesions HLA-DR, DQ and DP antigens were expressed more than in primary lesions, but there were no significant differences between ALM and NM. In primary melanoma, 82%, 75%, and 75% of lesions tested were stained by anti HLA-DR, DP and DQ monoclonal antibodies, respectively. In metastatic melanoma, 90% of the lesions tested were stained by anti HLA-DR, DP and DQ monoclonal antibodies. HLA-class II antigens on melanoma cells were much more expressed in cases of high levels of invasion, high degrees of lymphocyte infiltration, and lower melanin content.
Nakamura
T
T
Department of Dermatology, Kumamoto University Medical School.
Matsuno
M
M
Kageshita
T
T
Arao
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000556:secondary; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology* / Q000556:secondary
D006681:HLA-D Antigens