[Ambulatory treatment with cefuroxime-axetil of infectious bronchitis in patients sixty years of age or older: comparative study of the combination of amoxicillin and clavulanic acid].
The aim of this multicenter, prospective randomized trial was to compare the efficacy and safety of cefuroxime-axetil and amoxycillin/clavulanic acid for the treatment of infectious bronchitis in the elderly patient. Between January and April 1989, 157 out patients aged 60 years or more and presenting with infectious bronchitis were treated with either cefuroxime-axetil (250 mg bid), or the association amoxycillin/clavulanic acid (500 mg/125 mg bid). The two treatment groups were comparable at the time of inclusion; the mean age was 70 years, 82% of the patients were febrile, 75% presented purulent expectoration, 24% had a history of chronic bronchitis and 19% received symptomatic treatment was NSAIDs. The mean duration of treatment was 9 days. Clinical efficacy was assessed by the investigators. While fever and cough resolved similarly in the two groups, statistically fewer patients presented persistent purulent expectoration in the cefuroxime-axetil treatment group than in the group receiving amoxycillin/clavulanic acid (2% and 13%, respectively, p = 0.03). The proportion of patients who reported at least one side-effect was 3.6% in the cefuroxime-axetil treatment group against 21.6% of those who received the association (p = 0.006).
Hugonot
R
R
Service de Gérontologie Clinique, CHRU de Grenoble.
Hugonot
L
L
Pappo
M
M
Chiche
D
D
D000208:Acute Disease; D000368:Aged; D000553:Ambulatory Care; D000658:Amoxicillin / Q000627:therapeutic use*; D001991:Bronchitis / Q000188:drug therapy*; D002444:Cefuroxime / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002969:Clavulanic Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic
D002511:Cephalosporins; D002969:Clavulanic Acids; D000658:Amoxicillin; D002444:Cefuroxime; C040738:cefuroxime axetil
Traitement ambulatoire par le céfuroxime-axetil des bronchites infectieuses du sujet de soixante ans ou plus: étude comparative avec l'association d'amoxicilline et d'acide clavulanique.