Raised plasma endothelin-I concentration following cold pressor test.
Plasma concentration of immunoreactive endothelin-1 was measured by radioimmunoassay in 6 healthy subjects before and following cold pressor test by immersion of one fore-arm into ice-water. Mean (SEM) plasma endothelin-1 concentration rose from 1.2 (0.7) to peak value 8.4 (2.3) pg/ml in venous plasma from the immersed hand, and, reaching peak 2 minutes later, from 1.4 (0.5) to 4.6 (2.3) pg/ml in venous plasma from the contralateral hand. In 66 healthy control subjects, venous plasma concentration of endothelin-1 was 2.9 +/- 1.2 pg/ml (mean +/- SD). Exposure to cold is associated with raised blood levels of endothelin-1, which points to a relation between endothelin-1 and vasoconstriction associated with low temperature.
Unit of Clinical Physiology, Minerva Institute for Medical Research, Helsinki, Finland.
F
F
Fyhrquist
O
O
Saijonmaa
K
K
Metsärinne
I
I
Tikkanen
K
K
Rosenlöf
T
T
Tikkanen
D003080:Cold Temperature; D016232:Endothelins; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood*
D016232:Endothelins; D010455:Peptides