[Serum levels of salicylic acid in patients with psoriasis treated with 10% salicylic acid ointment].
Ten patients with psoriasis were treated for three days with salicylic acid ointment with vaseline vehicle. In all patients the serum concentration of salicylic acid increased systematically and the concentration depended on the amount of ointment used and on psoriasis form. Only in one case of exudative psoriasis the level of salicylic acid reached the value causing intoxication, and produced a diffuse inflammatory erythema with itching. The treatment caused no changes of biochemical indices.
Klinicznego Oddziału Dermatologicznego Wojskowego Szpitala Klinicznego w Bydgoszczy.
A
A
Zgrzybłowski
W
W
Paradecki
L
L
Przybyła
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism; D012459:Salicylates / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D020156:Salicylic Acid; D012869:Skin Absorption / Q000502:physiology; D013997:Time Factors
D009824:Ointments; D012459:Salicylates; D020156:Salicylic Acid
Stezenie kwasu salicylowego w surowicy krwi u chorych na łuszczyce leczonych 10% maścia salicylowa.