Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry.
beta-Hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I have been isolated from the urine of a patient with congenital erythropoietic porphyria by reversed phase high performance liquid chromatography. The compounds were characterized by their chemical behaviour and confirmed by liquid secondary ion mass spectrometry.
Guo
R
R
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.
Chai
W
W
Rideout
J M
JM
Lawson
A M
AM
Lim
C K
CK
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004920:Erythropoiesis; D006016:Glycolates / Q000652:urine*; D006801:Humans; D007773:Lactates / Q000652:urine*; D019344:Lactic Acid / Q000031:analogs & derivatives*; D008297:Male; D013058:Mass Spectrometry; D011164:Porphyrias / Q000097:blood / Q000151:congenital / Q000652:urine*; D014578:Uroporphyrins / Q000652:urine*
D006016:Glycolates; D007773:Lactates; D014578:Uroporphyrins; C031149:glycolic acid; D019344:Lactic Acid; C034103:uroporphyrin I; C031601:hydracrylic acid