[The cytoarchitectonics of hard chancre in rabbits with experimental syphilis exposed to soliusul'fon and cefamezine].
Twenty rabbits were infected with Treponema pallidum suspension. Ten animals were injected with solusulfone, the rest with cefamezin. Specific features of syphilis induced by a pool of Treponemas are described, such as T. pallidum ultrastructure, formation of a specific granule, form of the agent aggression. Solusulfone treatment was associated with activation of phagocytosis, that manifested by a shift of the incomplete/complete phagocytosis ratio towards the reaction completion; however, intact T. pallidum were detectable even in 72 hrs after the drug injection. Cefamezin had no effect on the cysts and cyst-like formations at the beginning of the treatment course but these forms of the agent were already undetectable in 48 hours.
Delektorskiĭ
V V
VV
Romanenko
V N
VN
Gupalo
L A
LA
Balakishieva
F I
FI
D000818:Animals; D001706:Biopsy; D002437:Cefazolin / Q000627:therapeutic use*; D002601:Chancre / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D004353:Drug Evaluation, Preclinical; D008854:Microscopy, Electron; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000648:ultrastructure; D013450:Sulfones / Q000627:therapeutic use*; D013587:Syphilis / Q000473:pathology*; D013997:Time Factors; D014210:Treponema pallidum / Q000187:drug effects / Q000648:ultrastructure
D013450:Sulfones; C009799:solasulfone; D002437:Cefazolin
Tsitoarkhitektonika tverdogo shankra u krolikov s éksperimental'nym sifilisom pri vozdeĭstvii soliusul'fonom i tsefamezinom.