Renal pathology in owl monkeys in Plasmodium falciparum vaccine trials.
Renal specimens of 16 owl monkeys (Aotus vociferans) were studied by light microscopy and immunohistochemistry during a vaccine trial with recombinant proteins of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. Deposition of IgG, C3, and P. falciparum antigens in the mesangium was demonstrated by the peroxidase anti-peroxidase (PAP) method. A relationship between the severity of parasitemia at the time of death and the presence of nephropathy was not apparent.
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio.
M
M
Iseki
J R
JR
Broderson
K G
KG
Pirl
I
I
Igarashi
W E
WE
Collins
M
M
Aikawa
D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis; D002427:Cebidae; D004195:Disease Models, Animal; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D008288:Malaria / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D014611:Vaccination; D014612:Vaccines; D014614:Vaccines, Synthetic
D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D011994:Recombinant Proteins; D014612:Vaccines; D014614:Vaccines, Synthetic