IgG-class insulin autoantibodies in autoimmune thyroid disease.
We studied the incidence of insulin autoantibodies (IAA) in 97 patients with autoimmune thyroid disease with an enzyme-linked immunosorbent assay. The sera were also tested for islet cell antibodies (ICA) and thyrotropin receptor antibodies (TRAb). IAA as assessed by a standard deviation score were present in 7 patients (7.2%). None of the patients were seropositive for ICA. Data from this random sampling and a retrospective study of 12 patients on antithyroid drug treatment indicated that the presence of IAA was not associated with TRAb.
Ng
W Y
WY
Department of Medicine, National University of Singapore.
Thai
A C
AC
Lui
K F
KF
Yeo
P P
PP
Cheah
J S
JS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D002231:Carbimazole / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007330:Insulin Antibodies / Q000097:blood*; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D011989:Receptors, Thyrotropin / Q000276:immunology; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D007330:Insulin Antibodies; D011989:Receptors, Thyrotropin; D002231:Carbimazole