[Pathogenetic and clinical significance of the adhesion molecule expression on T cells of the lung in sarcoid alveolitis].
A double immunofluorescence analysis of CD4+ cell population from bronchoalveolar lavage (BAL) fluid samples of patients with active pulmonary sarcoidosis was carried out. The results showed that, unlike BAL and peripheral blood CD4+ cells of healthy subjects, almost all BAL CD4+ cells of the patients highly express, besides CDw29 antigen, LFA-1 and ICAM-1 adhesion molecules. The co-expression of these molecules on BAL CD4+ cells during high intensity sarcoid alveolitis could represent a marker of immunological memory. The relevant pathogenetic and clinical implications of this observation are discussed.
Istituto di Clinica Medica I, Università di Perugia.
R
R
Gerli
R
R
Galandrini
E
E
Agea
P
P
Bini
R
R
Tognellini
D000268:Adhesiveness; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid; D015704:CD4 Antigens / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D008168:Lung / Q000276:immunology*; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D012507:Sarcoidosis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D015704:CD4 Antigens
Significato patogenetico e clinico dell'espressione di molecole di adesione su cellule T del polmone durante l'alveolite sarcoidea.