Use of tensiomin (captopril) in the antihypertensive treatment of haemodialysis patients.
The observations of a 16-week Tensiomin therapy of 10 hypertensive patients treated with hemodialysis have been discussed. The patients have been treated for about 5 years with hemodialysis, suffered from anuria and required besides systhematical ultrafiltration a combination antihypertensive therapy. Tensiomin was combined with Minipress, Trasicor, Depressan, Estulic and Corinfar by using three- or four-drug combinations. In the course of the administration of Tensiomin the doses of the other antihypertensive drugs could be decreased by 50% on average, while the blood pressure of the patients was normalized. By controlling the patients on weeks 1, 4, 12 and 16 of therapy toxic side-effects or notable pathological changes of the examined laboratory parameters (WBC, serum total protein, Na, K, Ca, P, bilirubin, blood sugar and SGOT values) were not seen. It has been concluded that Tensiomin is an effective drug in combination therapy applied for normalizing the hypertension of dialysed patients.
First Department of Medicine, University School of Medicine, Debrecen, Hungary.
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Kakuk
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Kurta
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Kárpáti
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Mátyus
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D016316:Guanfacine; D006146:Guanidines / Q000008:administration & dosage; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage; D010096:Oxprenolol / Q000008:administration & dosage; D010648:Phenylacetates / Q000008:administration & dosage; D011224:Prazosin / Q000008:administration & dosage; D006435:Renal Dialysis / Q000009:adverse effects*
D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine; D010096:Oxprenolol; D002216:Captopril; D009543:Nifedipine; D011224:Prazosin