N-[18F]fluoroacetyl-D-glucosamine: a potential agent for cancer diagnosis.
Positron labeled substrates such as sugars, amino acids, and nucleosides have been investigated for the in-vivo evaluation of biochemical processes in cancerous tissue. Hexosamines are obligatory structural components of many biologically important macromolecules, including membrane glycoproteins and mucopolysaccharide. We evaluated a new synthesized pharmaceutical, N-[18F]fluoroacetyl-D-glucosamine (18F-FAG), which is a structural analog of N-acetyl-D-glucosamine. C3H/HeMsNRS mice bearing spontaneous hepatomas were used for the tissue distribution study. At 60 min after injection, high uptakes were found in tumor (5.16, mean value of %dose/g), liver (3.71), and kidney (3.27). The tumor uptake of 18F-FAG showed the highest value in all tissue. In the PET study, VX-2 carcinoma of the rabbit was clearly visualized. Our preliminary results suggest that 18F-FAG has potential as a new agent for tumor imaging.
Department of Radiology and Nuclear Medicine, Tohoku University, Japan.
T
T
Fujiwara
K
K
Kubota
T
T
Sato
T
T
Matsuzawa
M
M
Tada
R
R
Iwata
M
M
Itoh
J
J
Hatazawa
K
K
Sato
H
H
Fukuda
D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D001345:Autoradiography; D005462:Fluorine Radioisotopes; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D011817:Rabbits; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; C022140:N-fluoroacetyl-D-glucosamine; D000117:Acetylglucosamine