Molecular genetics of polyamine synthesis in eukaryotic cells.
The polyamines putrescine, spermidine and spermine are important cellular constituents involved in the regulation of cell growth and differentiation. Their intracellular levels are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and excretion. As a result of the application of molecular biology techniques, some of these mechanisms are presently being unravelled, and are providing a basis for the rational development of novel agents effective against proliferative disorders and various parasitic diseases.
Department of Zoophysiology, University of Umeå, Sweden.
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D012437:Adenosylmethionine Decarboxylase / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D015317:Biogenic Polyamines / Q000096:biosynthesis*; D002477:Cells / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D008967:Molecular Biology; D009955:Ornithine Decarboxylase / Q000235:genetics
D015317:Biogenic Polyamines; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase