[Symptomatic HIV infection. Approaches to rational therapy].
The symptomatic HIV-infection is characterized by the involvement of multiple organs with a predominance of infectious complications. Treatment of these complications usually follows established therapeutic regimens for the resulting diseases of affected organs. Successful reconstitution of the immunodeficiency resulting from HIV-infection has been unsuccessful so far. Recently, promising results have been obtained by the treatment of patients with antiviral substances which inhibit viral replication. The prototype substance, Zidovudine (AZT) has been proven to be beneficial for patients in advanced stages of the disease and more recently has been shown to delay the occurrence of full-blown AIDS in patients with AIDS-related complex. In consequence, substances with less side effects such as Dideoxycytidine or Dideoxyinosine are currently under investigation.
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KM
Sektion Onkologie/Immunologie, Universitäts-Kinderklinik Heidelberg.
D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007231:Infant, Newborn; D009894:Opportunistic Infections / Q000628:therapy*
D000998:Antiviral Agents
Die symptomatische HIV-infektion. Ansätze zu einer sinnvollen Therapie.