Effects of methyl isocyanate on rat brain cells in culture.
Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to brain cells and the response was dose related. The observations were supported by light and electron microscopy.
Anderson
D
D
British Industrial Biological Research Association, Carshalton, Surrey.
Goyle
S
S
Phillips
B J
BJ
Tee
A
A
Beech
L
L
Butler
W H
WH
D000818:Animals; D000986:Antisickling Agents / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D002478:Cells, Cultured; D003485:Cyanates / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D017953:Isocyanates; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000986:Antisickling Agents; D003485:Cyanates; D017953:Isocyanates; C008461:methyl isocyanate