Metabolites of testosterone: significance in the vital economy.
Testosterone is metabolized by practically every tissue in the body to a large variety of related steroids. The metabolites vary with each tissue and appear to be formed to meet the specific needs of the particular tissue and animal. The many biologic actions of testosterone do not change in parallel in the various metabolites. Many of the metabolites show interesting differences in their relative biologic effects. A large number and variety of steroid-metabolizing enzymes (oxidoreductases, reductases, hydroxylases, aromatases) are involved. Some have been partially purified. The 17 beta-oxidoreductases of the cytosol of the guinea pig liver and kidney have been purified and characterized.
Department of Experimental Endocrinology, University of Alabama, Birmingham.
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Kochakian
D000818:Animals; D004798:Enzymes / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D004798:Enzymes; D013739:Testosterone