Severe pulmonary arterial hypertension due to toxic oil syndrome: a new cause of plexogenic arteriopathy.
Ten patients with severe pulmonary hypertension due to Toxic Oil Syndrome (TOS) (3 men, 7 women; mean age 27.9 +/- 11.23 yrs.) are presented. The pulmonary vessels were examined with a micromorphometric technique. All patients had intimal fibrosis of the arteries and veins. Seven also had a thrombus in different stages. All arteries were shown to have medial hypertrophy. Plexiform lexions were found in eight cases. It is concluded that TOS can produce severe pulmonary hypertension histologically undistinguishable from the primary form. TOS can be added to the list of diseases causing plexogenic arteriopathy.
Department of Pathology, Hospital 12 de Octubre, Madrid, Spain.
M J
MJ
Mestre de Juan
F J
FJ
Martinez Tello
C
C
Gomez Pajuelo
C
C
Saenz de la Calzada
J L
JL
Moya Mur
J C
JC
Tascon Perez
F
F
Lombera Romero
M A
MA
Gomez Sanchez
D005229:Fatty Acids, Monounsaturated; D005352:Fibromuscular Dysplasia / Q000139:chemically induced*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D010938:Plant Oils / Q000009:adverse effects*; D011651:Pulmonary Artery / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects; D000074262:Rapeseed Oil; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology; D013577:Syndrome
D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil