Pulmonary-renal syndrome with "triad" involvement due to small vessel vasculitis.
We describe the clinical course and morphologic findings of a 22-year-old woman presenting with a systemic disease that included nasal ulceration, hemoptysis and rapidly progressive renal failure. Biopsies of nasal septum and lung revealed small vessel leukocytoclastic angiitis while renal biopsy showed a diffuse crescentic glomerulonephritis. Immunosuppressive therapy resulted in remission of clinical symptoms and resolution of glomerulonephritis as documented in a followup biopsy. Although her clinical presentation with triad organ involvement strongly suggested Wegener's granulomatosis, this case illustrates that other varieties of vasculitis may mimic Wegener's granulomatosis.
Department of Medicine, University of Iowa College of Medicine, Iowa City 52242.
B N
BN
Doebbeling
S M
SM
Bonsib
W P
WP
Walker
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D014890:Granulomatosis with Polyangiitis / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D013577:Syndrome; D014657:Vasculitis / Q000473:pathology*