Estimation of sensitivity and specificity of site-specific diagnostic tests.
Clinical trials designed to estimate the sensitivity and specificity of periodontal diagnostic tests often use multiple sites per patient as experimental units of analyses. Since site-specific test results within a patient are dependent observations, a correlated binomial model should be employed to estimate the sensitivity and specificity of these diagnostic tests. Ignoring the within-patient correlation can result in an over- or underestimation of the true standard errors.
Hujoel
P P
PP
Department of Biostatistics, School of Public Health, University of Michigan, School of Dentistry, Ann Arbor.
Moulton
L H
LH
Loesche
W J
WJ
D001439:Bacteroides / Q000302:isolation & purification; D006801:Humans; D015233:Models, Statistical; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000382:microbiology; D011237:Predictive Value of Tests; D011336:Probability; D012680:Sensitivity and Specificity; D014208:Treponema / Q000302:isolation & purification