Efficiency of communication between tumour cells in collagen gel cultures.
Mixtures of drug-resistant and drug-sensitive tumour cells growing in 3-dimensional boluses in collagen gel matrix are shown to be effectively coupled so that the response of the mixture is significantly influenced by a subpopulation making up only 1% of the total cells.
E. Walter Albachten Department of Immunology, Michigan Cancer Foundation, Detroit 48201.
F R
FR
Miller
D
D
McEachern
B E
BE
Miller
D000630:Aminopterin / Q000494:pharmacology; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051379:Mice; D010042:Ouabain / Q000494:pharmacology; D013866:Thioguanine / Q000494:pharmacology; D013936:Thymidine / Q000494:pharmacology
D007042:Hypoxanthines; D019271:Hypoxanthine; D010042:Ouabain; D003094:Collagen; D013866:Thioguanine; D000630:Aminopterin; D013936:Thymidine