[Antiseptic properties of saliva and metabolism of activated oxygen in neutrophils: comparison of the 2 enzymatic bactericidal systems and of their behavior in an acid environment].
Growth control of anaerobes in the oral cavity, is secured--among other means--by: 1) phagocytosis of opsonized bacteria; 2) synthesis of hypothiocyanite by the salivary peroxidase system. The former may be inhibited by bacterial acid byproducts. As for the salivary hypothiocyanite, it proved itself able of hindering in vitro the growth of bacterial strains known as customary periodontal pathogens. Its possible effectiveness in vivo remains however hypothetical in the case of deep gingival pockets according to the poor diffusion there of salivary components.
Service de Stomatologie des Hôpitaux St-Pierre et Brugmann, Université libre de Bruxelles.
P
P
Courtois
P
P
Majerus
I
I
Mandelbaum
M
M
Pourtois
D000900:Anti-Bacterial Agents / Q000378:metabolism; D001421:Bacteria, Anaerobic / Q000254:growth & development*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D010544:Peroxidases / Q000494:pharmacology*; D010587:Phagocytosis; D012463:Saliva / Q000201:enzymology*; D013861:Thiocyanates / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D013861:Thiocyanates; C014607:hypothiocyanite ion; D010544:Peroxidases
Pouvoir antiseptique de la salive et métabolisme de l'oxygène activé dans les neutrophiles: comparaison de deux systèmes enzymatiques bactéricides et de leur comportement en milieu acide.