Effects of ultraviolet irradiation on prostaglandin-E2 production by cultured corneal stromal cells.
We examined the effects of ultraviolet (UV) irradiation on the release of prostaglandin E2 (PGE2) by rabbit corneal stromal cells in culture. Considerable amounts of PGE2 were present in the media of control corneal cultures following 1, 2, 4, 8 and 24 hr of incubation. Irradiation with UV-A (320-400 nm) for 30 min resulted in more than a 50% increase in PGE2 release. Dexamethasone inhibited PGE2 release by corneal stromal cells. It was, however, ineffective in protecting the cells from the UV-induced release of PGE2.
Department of Ophthalmology, University of California, San Diego, La Jolla.
R N
RN
Weinreb
B Y
BY
Yue
G A
GA
Peyman
D000818:Animals; D002478:Cells, Cultured; D003319:Corneal Stroma / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D003907:Dexamethasone / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism*; D011817:Rabbits; D014466:Ultraviolet Rays
D003907:Dexamethasone; D015232:Dinoprostone