Comparative study of adjuvant induced arthritis in susceptible and resistant strains of rats. II. Effect of oral administration of BCG and PPD.
In rats of the Holtzman strain, susceptible to the development of adjuvant induced arthritis (AIA), oral administration of BCG significantly inhibited the development of the disease. Oral treatment with purified protein derivative (PPD) had no effect. In the resistant Buffalo rats, however, oral administration of BCG and PPD enhanced the lesions. Since oral administration of antigens has been described to induce suppressor cells, our results suggest that the development of AIA is controlled by suppressor mechanisms, which fail to be activated in the susceptible strain, but are stimulated by the oral administration of BCG.
Department of Pharmacy and Biochemistry, University of Maringa, Parana, Brazil.
C A
CA
Bersani-Amado
J A
JA
Barbuto
S
S
Jancar
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000276:immunology / Q000502:physiology; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D001500:BCG Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D004198:Disease Susceptibility; D007113:Immunity, Innate; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D051381:Rats; D011915:Rats, Inbred BUF
D000941:Antigens; D001500:BCG Vaccine