[Hemolytic-uremic syndrome in an adult with T-cryptantigen liberation].
Haemolytic uraemic syndrome was diagnosed in a 36-year-old woman with acute renal failure (creatinine 10.5 mg/dl), haemolytic anaemia (haemoglobin 9.7 g/dl, lactate dehydrogenase 1926 U/l) and thrombopenia (98,000/microliters). After initial plasmaphereses and high doses of furosemide all symptoms disappeared within three weeks. The lectin tests demonstrated that the illness was connected with the liberation of T-crypt-antigen (Thomsen-Friedenreich antigen) on the erythrocytes. This special form of the haemolytic uraemic syndrome (neuraminidase-induced haemolytic uraemic syndrome) has previously been observed almost exclusively in children. However, for diagnosis and differentiation of haemolytic uraemic syndromes the presence of liberated T-antigen on erythrocytes should also be tested for in adults.
Abteilung Nephrologie und Rheumatologie, Universität Göttingen.
K W
KW
Rumpf
R
R
Lynen
R
R
Verwiebe
H
H
Schilling
H
H
Neumeyer
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004187:Disaccharides / Q000097:blood*; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D007519:Isoantigens / Q000097:blood*; D010949:Plasma; D010956:Plasmapheresis
D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; D007519:Isoantigens; C016467:Thomsen-Friedenreich antigen
Hämolytisch-urämisches Syndrom des Erwachsenen mit T-Kryptantigen-Freilegung.