Desipramine blocks stress-induced prolactin release in rats: role of central beta-2 adrenoceptors.
1. The present study was designed to examine the relationship between beta-adrenoceptors and the enhanced, sustained prolactin secretion induced by immobilization stress in rats. 2. Chronic administration of desipramine (15 mg kg-1 day-1, intraperitoneally) for 7 days, a procedure that desensitizes central beta-adrenoceptors, partially inhibits stress-induced prolactin release. 3. Intracerebroventricular administration of the beta-2 adrenoceptor agonist salbutamol (1 microgram/rat) to rats pretreated with desipramine for 7 days, 15 min before immobilization, significantly relieved the inhibition by desipramine 5 and 10 min after the initiation of stress but the effect was not demonstrable after 20 and 40 min. 4. We conclude that beta-2 adrenoceptors play a role in the control of prolactin release in response to stress.
de-Castro-e-Silva
E
E
Departamento de Fisiologia, Universidade Federal da Bahia, Salvador, BA, Brasil.
Ramalho
M J
MJ
Midlej
M
M
Cobas
C
C
Machado
A
A
Antunes-Rodrigues
J
J
D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003891:Desipramine / Q000494:pharmacology* / Q000627:therapeutic use; D007276:Injections, Intraventricular; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood*
D011388:Prolactin; D000420:Albuterol; D003891:Desipramine