Preliminary results on the frequency of the delta F508 mutation in cystic fibrosis patients from the USSR.
The frequency of the delta F508 mutation in a sample of 29 cystic fibrosis (CF) families from the USSR is equal to 44.8%, in agreement with previously reported haplotype data. If confirmed on a larger sample of CF patients from the USSR, this result might be indicative of the presence of a larger heterogeneity of CF mutations in the Soviet population than in other European populations.
Laboratoio di Genetica Molecolare, Istituto G. Gaslini, Genoa, Italy.
P
P
Ronchetto
M
M
Devoto
A
A
Puliti
G
G
Romeo
B
B
Sokolov
V N
VN
Kalinin
S G
SG
Vorsanova
G V
GV
Krainiaia
B Y
BY
Reznik
D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D009154:Mutation; D014586:USSR / Q000453:epidemiology