Topical steroids in the treatment of central and paracentral corneal ulcers.
During an 18-month period a prospective randomised trial was conducted on 40 selected patients with bacterial corneal ulcers. Two groups were compared: one was treated with antibiotic only and the other with antibiotic plus steroid. Complications were similar in the two groups. No delay in healing rate of the ulcers was seen with the use of topical steroid. Two methods of assessing visual improvement are discussed, but it was not possible to demonstrate a difference in visual outcome between the two groups.
Carmichael
T R
TR
Department of Ophthalmology, University of the Witwatersrand, Johannesburg, Republic of South Africa.
Gelfand
Y
Y
Welsh
N H
NH
D000287:Administration, Topical; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use; D003320:Corneal Ulcer / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D016032:Randomized Controlled Trials as Topic
D005839:Gentamicins; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D002437:Cefazolin