Association of EGF receptor expression with proliferating cells and of ras p21 expression with differentiating cells in various skin tumours.
The localization of DNA replicating cells, epidermal growth factor (EGF) receptor-expressing cells and ras oncogene product p21 (p-21ras) positive cells were examined in various skin tumours to elucidate the role of EGF receptor and p21ras in the epidermis. Normal skin, keratoacanthoma (KA), solar keratosis (SK), Bowen's disease (BD), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and extramammary Paget's disease (PD) were studied. EGF receptors were seen in proliferating layers, where DNA replicating cells localize, but p21ras was found in the more differentiated layers. We conclude that EGF receptor expression is closely associated with cellular proliferation, but p21ras may play a role in the differentiation of cells in various skin tumours.
Kikuchi
A
A
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Amagai
M
M
Hayakawa
K
K
Ueda
M
M
Hirohashi
S
S
Shimizu
N
N
Nishikawa
T
T
D002454:Cell Differentiation; D002455:Cell Division; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras); D012867:Skin / Q000032:analysis / Q000033:anatomy & histology / Q000473:pathology; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*
D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)