Protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae.
Subjects prone to recurrent acute bronchitis were admitted to a six-month double-blind clinical study, in which the value of oral immunization with a preparation of killed Haemophilus influenzae was tested. Most subjects had early smoking-related chronic lung disease, unrecognized by either the patient or his/her doctor. Subjects taking the active agent had a 41% reduction in the total number of episodes of acute bronchitis (P = 0.16), a 60% reduction in the number of episodes of acute wheezy bronchitis (P = 0.02) and a 58% reduction in antibiotic use (P = 0.07). The power of analysis was restricted by the small study group. Parameters of episode severity favoured the test group, suggesting that individual episodes of acute bronchitis in subjects taking an oral preparation of killed H. influenzae were less severe than in those taking placebo tablets. Oral immunization with H. influenzae selectively reduced the increase in colonization of the oropharynx with H. influenzae which occurred in the group taking placebo. This is the first demonstration that the common mucosal system can be activated to modify a colonization pattern at a distant site.
Royal Newcastle Hospital, NSW.
R L
RL
Clancy
A W
AW
Cripps
V
V
Gebski
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001991:Bronchitis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D004198:Disease Susceptibility; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012044:Regression Analysis; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D015164:Vaccines, Inactivated / Q000008:administration & dosage*
D001428:Bacterial Vaccines; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial; D015164:Vaccines, Inactivated