Effect of blood filling in intramyocardial vessels on coronary arterial inflow.
The influence of the filling condition of the unstressed volume (UV) of intramyocardial vessels on the diastolic coronary arterial pressure-flow relationship was analyzed. UV is defined as the blood volume at zero transmural pressure. In seven anesthetized, paced dogs with induced heart block, coronary artery inflow was occluded so that blood in the UV was displaced into the coronary vein by myocardial contraction. After pacing was turned off, coronary perfusion pressure was increased stepwise to seven target pressures (20-90 mmHg). After reperfusion, left anterior descending coronary arterial (LAD) flow reached an initial quasi-steady level, but great cardiac venous (GCV) flow was absent (UV-unfilled phase). With reappearance of the GCV flow (UV-filled phase), LAD flow decreased to a final steady level. Pressure-flow relationships during both phases were linear (r = 0.97-0.99). The inverse of the slope of the pressure-flow relationship during the UV-filled phase, 0.69 +/- 0.08 mmHg.min.ml-1, was significantly higher than that during the UV-unfilled phase, 0.55 +/- 0.06 mmHg.min.ml-1 (P less than 0.01), although the zero-flow pressure intercepts were similar (18.9 +/- 1.8 mmHg for UV filled vs. 19.9 +/- 2.2 for UV unfilled). These results indicate that diastolic coronary arterial inflow is impeded by a blood volume within intramyocardial vessels that exceeds the UV.
Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Japan.
M
M
Goto
K
K
Tsujioka
Y
Y
Ogasawara
Y
Y
Wada
S
S
Tadaoka
O
O
Hiramatsu
M
M
Yanaka
F
F
Kajiya
D000818:Animals; D001158:Arteries; D001794:Blood Pressure; D001810:Blood Volume; D003326:Coronary Circulation; D004285:Dogs; D005260:Female; D008297:Male; D008955:Models, Cardiovascular; D014463:Ultrasonography; D014655:Vascular Resistance