Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei.
Administration of picroliv, a standardized fraction of alcoholic extent of Picrorhiza kurroa (3-12 mg/kg/day for two weeks) simultaneously with P. berghei infection showed significant protection against hepatic damage in Mastomys natalensis. The increased levels of serum glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase, lipoprotein-X (LP-X) and bilirubin in the infected animals were marked reduced by different doses of picroliv. In the liver, picroliv decreased the levels of lipid peroxides and hydroperoxides and facilitated the recovery of superoxide dismutase and glycogen. Picroliv had no effect on the degree of parasitaemia.
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow.
R
R
Chander
Y
Y
Dwivedi
R
R
Rastogi
S K
SK
Sharma
N K
NK
Garg
N K
NK
Kapoor
B N
BN
Dhawan
D000818:Animals; D002934:Cinnamates / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D008109:Liver Diseases, Parasitic / Q000517:prevention & control*; D008288:Malaria / Q000150:complications*; D008297:Male; D009115:Muridae; D010936:Plant Extracts / Q000627:therapeutic use*; D010962:Plasmodium berghei; D014641:Vanillic Acid / Q000627:therapeutic use*
D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; C057463:kutkin; D014641:Vanillic Acid