Post-translational polymorphism of human IgA identified by immunoisoelectrofocusing.
Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S. The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment. It can be postulated, therefore, that S encodes a sialyltransferase which attaches sialic acid at the outer prosthetic chains of IgA.
Department of Cell Biology, University of Calabria, Arcavacata, CS, Italy.
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De Benedictis
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Rose
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Brancati
D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic; D011499:Protein Processing, Post-Translational / Q000235:genetics; D012799:Sialyltransferases / Q000235:genetics; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D007070:Immunoglobulin A; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase