Prognostic implication of ecto-5'-nucleotidase activity in acute lymphoblastic leukemia.
Ecto-5'-nucleotidase (5'-N) activity was determined in 191 patients (71 children and 120 adults) with acute leukemia. Elevated values for 5'-N were registered in common acute lymphoblastic leukemia (ALL), but blast cells of T-cell ALL (T-ALL) and common ALL antigen-negative non-T-ALL had low enzyme activity comparable with the values of acute non-lymphocytic leukemia. Dependence of remission duration on 5'-N activity was analyzed in 74 adults with ALL, treated similarly in a prospective multicenter trial. The remission curves for ALL patients with 5'-N activity lower than 10 nmol/h x 10(6) cells were substantially and significantly better than those of patients with high activity (greater than 10 nmol/h x 10(6) cells). This difference was also evident in the immunologic subclass common ALL. Statistical evaluation showed that an interaction between immunologic subtype of the blast cells and their 5'-N activity had prognostic significance for remission duration. In addition to the independent factor, initial age, this interaction was also prognostic for survival.
Gutensohn
W
W
Institute of Anthropology and Human Genetics, University of Munich, Federal Republic of Germany.
Thiel
E
E
D015720:5'-Nucleotidase / Q000097:blood / Q000378:metabolism*; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D004796:Clinical Enzyme Tests; D006801:Humans; D016130:Immunophenotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012074:Remission Induction
D014408:Biomarkers, Tumor; D015720:5'-Nucleotidase