Co-enzyme Q10: a new drug for cardiovascular disease.
Co-enzyme Q10 (ubiquinone) is a naturally occurring substance which has properties potentially beneficial for preventing cellular damage during myocardial ischemia and reperfusion. It plays a role in oxidative phosphorylation and has membrane stabilizing activity. The substance has been used in oral form to treat various cardiovascular disorders including angina pectoris, hypertension, and congestive heart failure. Its clinical importance is now being established in clinical trails worldwide.
Department of Medicine, Mt. Sinai Hospital and Medical Center, New York, New York.
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Frishman
D000284:Administration, Oral; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D003067:Coenzymes; D004317:Doxorubicin / Q000037:antagonists & inhibitors; D005609:Free Radicals; D006324:Heart Arrest, Induced; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007511:Ischemia / Q000188:drug therapy; D015424:Reperfusion; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
D003067:Coenzymes; D005609:Free Radicals; D014451:Ubiquinone; D004317:Doxorubicin; C024989:coenzyme Q10