Effects of shosaikoto, an oriental herbal medicinal mixture, on restraint-stressed mice.
Restraint-induced stress produced an inhibition of humoral immune responses accompanied by a decrease of rectal temperature and motor activity. Diazepam and levamisole restored the decrease of humoral immune responses. Furthermore, diazepam restored the decrease of rectal temperature. Shosaikoto, an oriental herbal medicinal mixture, restored the stress-induced inhibition of humoral immune responses and rectal temperature.
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
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Amagaya
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Ogihara
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology*; D013312:Stress, Physiological / Q000188:drug therapy* / Q000276:immunology
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C461321:shosaikoto-go-keishika-shakuyakuto; D007978:Levamisole; D003975:Diazepam