Effects of cyclohexane, an industrial solvent, on the yeast Saccharomyces cerevisiae and on isolated yeast mitochondria.
Little information on the effects of cyclohexane at the cellular or subcellular level is available. In Saccharomyces cerevisiae, cyclohexane inhibited respiration and diverse energy-dependent processes. In mitochondria isolated from S. cerevisiae, oxygen uptake and ATP synthesis were inhibited, although ATPase activity was not affected. Cyclohexane effects were similar to those reported for beta-pinene and limonene, suggesting that the cyclohexane ring in these monoterpenes may be a determinant for their biological activities.
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F.
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Uribe
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Rangel
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Espínola
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Aguirre
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D003510:Cyclohexanes / Q000633:toxicity*; D000431:Ethanol / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism
D003510:Cyclohexanes; D000431:Ethanol; D000255:Adenosine Triphosphate; D005947:Glucose; D011188:Potassium