Antacids in gastric ulcer treatment: evidence of cytoprotection.
Antacids are more effective than placebo, and their efficacy is comparable to that of H2-blockers in gastric ulcer healing even though the healing time is about 2 weeks longer than with H2-blockers. Some observations in animals and healthy subjects may indicate that antacids (particularly those containing aluminium hydroxide) have a protective effect on the gastroduodenal mucosa in that they increase the production of prostanoids and sulphydryl-containing compounds. We showed that 10 days' treatment with high-dose antacids (Maalox TC) is able to increase 6-keto-PGF1 alpha production from cultured biopsy specimens of patients with gastric ulcer. These data could constitute a further indication in the treatment of peptic disease.
Medical Pathology I, University of Bologna, Italy.
G
G
Gasbarrini
P
P
Andreone
M
M
Baraldini
C
C
Cursaro
E
E
Micaletti
D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000818:Animals; D000863:Antacids / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy*; D013997:Time Factors
D000863:Antacids; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide