Protamine-histone replacement and DNA replication in the male mouse pronucleus.
The protamine to histone replacement in fertilized mouse eggs was studied by using antibodies to these proteins. Its course was followed with respect to DNA replication by autoradiography of 3H-thymidine-labeled fertilized eggs. It was found that protamines were replaced by histones before the onset of DNA replication.
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
S
S
Nonchev
R
R
Tsanev
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001345:Autoradiography; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D004261:DNA Replication; D005260:Female; D005455:Fluorescent Antibody Technique; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011479:Protamines / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D000911:Antibodies, Monoclonal; D006657:Histones; D011479:Protamines; D013936:Thymidine