The role of membrane biophysical properties in the regulation of protein kinase C activity.
Under physiological conditions, protein kinase C is active when bound to membranes. Like most membrane-bound enzymes, its activity is dependent on the nature of its lipid environment. In this article, Richard Epand and David Lester describe the relationship between the ability of specific membrane-active agents to alter the biophysical properties of the lipid environment and their potential to modulate protein kinase C activity. They argue that this can lead to a greater understanding of the mechanism of inhibition and activation of protein kinase C through modulation of the bulk biophysical properties of the membrane, and may provide a new approach to the development of a more specific set of inhibitors.
Department of Biochemistry, McMaster University Health Sciences Center, Hamilton, Ontario, Canada.
R M
RM
Epand
D S
DS
Lester
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*
D011493:Protein Kinase C