Release of intracellularly stored Ca2+ by inositol 1,4,5-trisphosphate--an overview.
1. Inositol 1,4,5-trisphosphate (I(1,4,5)P3) releases Ca2+ from ATP-dependent Ca2+ stores in permeabilized cells and in microsomal fractions. 2. Various factors affect the amount of Ca2+ released by I(1,4,5)P3. 3. The molecular mechanism involved in the I(1,4,5)P3-induced Ca2+ release is now being investigated and I(1,4,5)P3-specific receptors and/or specific release channels are being given special attention. 4. While the I(1,4,5)P3-sensitive Ca2+ stores are presumed to locate at the endoplasmic reticulum, the relation between the I(1,4,5)P3- and the agonist-sensitive Ca2+ stores remains to be elucidated.
Medical Education Center, Kyushu University, Fukuoka, Japan.
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Yamamoto
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Kanaide
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007292:Inosine Nucleotides / Q000494:pharmacology*; D007293:Inosine Triphosphate / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D007292:Inosine Nucleotides; D007293:Inosine Triphosphate; D002118:Calcium