The roles of angiotensin II and prostaglandins in the regulation of the glomerular filtration of albumin.
Angiotensin (Ang) II and prostaglandins, especially prostaglandins E2 and I2, regulate the glomerular filtration of albumin. Albuminuria can be induced by angiotensin II and possibly by prostaglandins. Angiotensin converting enzyme inhibition with captopril, enalapril or lisinopril reduces albuminuria and glomerular injury in experimental and clinical renal diseases, especially diabetes mellitus. Inhibition of prostaglandin synthesis with non-steroidal anti-inflammatory drugs reduces albuminuria in nephrotic patients regardless of the aetiology of the nephrosis. Judicious clinical use of either class of therapy can result in sustained reductions (50-75%) in proteinuria and possible attenuation of the rate of decline of glomerular function.
Dunn
M J
MJ
Case Western Reserve University School of Medicine, Cleveland, Ohio.
D000804:Angiotensin II / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000503:physiopathology*; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D014563:Urodynamics / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D000804:Angiotensin II