Hepatopulmonary amoebiasis. Efficacy of various treatment regimens containing dehydroemetine and/or metronidazole.
Thirty three patients with hepatopulmonary amoebiasis were studied. Pulmonary involvement was observed in 55%, pleuro-pulmonary lesions in 30%. Typical chocolate coloured sputum was obtained in 24% and pleural fluid in 21% of patients. Entamoeba histolytica were demonstrable in the sputum in only 6% and in the pleural fluid in 15%. The best therapeutic results were obtained with a combination of dehydroemetine and metronidazole. However, metronidazole was found to be nearly as effective as dehydroemetine, and metronidazole 400 mg and 800 mg were equally effective.
Hospital for Chest Diseases and Tuberculosis, Sawai Man Singh Medical College, Jaipur.
N K
NK
Jain
A
A
Madan
T N
TN
Sharma
D K
DK
Sharma
R G
RG
Mandhana
D000293:Adolescent; D000328:Adult; D000563:Amebicides; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004640:Emetine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008174:Lung Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D000563:Amebicides; D008795:Metronidazole; C086742:dehydroemetine; D004640:Emetine