The pharmacokinetics of agents used to treat status epilepticus.
A thorough understanding of the pharmacologic properties of lipid-soluble drugs is essential when using these agents to treat status epilepticus. In addition to physiologic factors, such as blood pressure and cerebral blood flow, pharmacokinetic principles, including half-life, distribution, elimination, and volume of distribution (with special regard to an agent's lipid-solubility rating), should be applied. These factors, in toto, will influence the choice of drug, its loading dose, and its therapeutic dose.
Browne
T R
TR
Department of Neurology and Pharmacology, Boston University School of Medicine, MA.
D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003975:Diazepam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007273:Injections, Intramuscular; D050356:Lipid Metabolism; D010634:Phenobarbital / Q000008:administration & dosage / Q000493:pharmacokinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D012995:Solubility; D013226:Status Epilepticus / Q000188:drug therapy*
D000927:Anticonvulsants; D010672:Phenytoin; D003975:Diazepam; D010634:Phenobarbital