An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.
Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential. The spectrum of toxicologic information sought on selected chemicals has been broadened by the multidisciplinary approach to evaluating chemicals. This paper describes the scientific rationale and experimental processes used by NTP in designing studies. Also, an outline of current NTP protocols are given for prechronic and chronic toxicity/carcinogenicity studies.
National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, NC 27709.
R S
RS
Chhabra
J E
JE
Huff
B S
BS
Schwetz
J
J
Selkirk
D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D004782:Environmental Health; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D013997:Time Factors
D002273:Carcinogens; D004364:Pharmaceutical Preparations