Recurrent allograft antiglomerular basement membrane glomerulonephritis in a patient with Alport's syndrome.
A patient with Alport's syndrome and chronic renal failure received a cadaver kidney graft. Four months after the transplantation, he developed glomerulonephritis induced by anti-glomerular basement membrane (GBM) antibody. The graft failed, and the patient returned to haemodialysis. Twenty-two months later the patient received a second cadaver kidney graft. Ten months after the second transplant, he developed a recurrent anti-GBM glomerulonephritis. This observation suggests that anti-GBM disease can recur in a second transplanted kidney in a patient with Alport's syndrome.
Department of Nephrology, Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia.
Z
Z
Rassoul
A A
AA
al-Khader
M
M
al-Sulaiman
J M
JM
Dhar
P
P
Coode
D000293:Adolescent; D000906:Antibodies / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D009394:Nephritis, Hereditary / Q000276:immunology / Q000601:surgery*; D012008:Recurrence
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G