A new myocardial imaging agent: synthesis, characterization, and biodistribution of gallium-68-BAT-TECH.
In order to develop a new myocardial perfusion agent for positron emission tomography (PET), a new lipid-soluble gallium complex was evaluated. Synthesis, radiolabeling, characterization, and biodistribution of a unique gallium complex, [67Ga]BAT-TECH (bis-aminoethanethiol-tetraethyl-cyclohexyl), are described. The complex formation between Ga+3 and BAT-TECH ligand is simple, rapid, and of high yield (greater than or equal to 95%). This process is amenable to kit formulation. The complex has a net charge of +1 and a Ga/ligand ratio of 1:1. Biodistribution in rats shows high uptake in the heart as well as in the liver. When [68Ga] BAT-TECH was injected into a monkey, the heart and liver are clearly delineated by PET imaging, suggesting that this complex may be a possible tracer for myocardial perfusion imaging.
Kung
H F
HF
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Liu
B L
BL
Mankoff
D
D
Kung
M P
MP
Billings
J J
JJ
Francesconi
L
L
Alavi
A
A
D000818:Animals; D003543:Cysteamine / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D005710:Gallium Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging*; D007553:Isotope Labeling; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D005710:Gallium Radioisotopes; C065900:bis(aminoethanethiol)tetraethyl-cyclohexyl-gallium(68) complex; D003543:Cysteamine