Mechanisms of toxic cell injury.
The biochemical mechanisms by which xenobiotic agents initiate cell injury involve networks of interactions at a variety of molecular and structural targets. The author highlights current concepts in six major areas of investigation: covalent binding, oxidative stress, alterations of glutathione and protein thiols, peroxidation and hydrolysis of phospholipids, mitochondrial deenergization, and alterations of intracellular calcium homeostasis.
Division of Environmental Medicine and Toxicology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
J W
JW
Snyder
D002118:Calcium / Q000378:metabolism; D002477:Cells / Q000187:drug effects*; D004734:Energy Metabolism; D005978:Glutathione / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D008565:Membrane Proteins; D010743:Phospholipids; D005978:Glutathione; D010100:Oxygen; D002118:Calcium