Blood and tissue zinc levels in spontaneously hypertensive rats.
Zinc (Zn) determinations were performed on blood plasma and red cells, liver, heart, adrenals, and spleen of spontaneously hypertensive (SHR) and control normotensive (WKY) male rats, 20 weeks of age. SHR revealed higher red cell (p = 2 x 10(-5)) and heart (p = 0.007) Zn levels than WKY rats. The water content of organs was the same in the two strains. When compared with published data, these results suggest an association between high cell Zn levels and hypertension, the meaning of which is briefly discussed.
CNRS, Faculty of Pharmacy, University of Paris V, France.
J G
JG
Henrotte
M
M
Santarromana
G
G
Franck
R
R
Bourdon
D000311:Adrenal Glands / Q000737:chemistry; D000818:Animals; D001834:Body Water / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry; D006973:Hypertension / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000737:chemistry; D008297:Male; D009206:Myocardium / Q000737:chemistry; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011921:Rats, Inbred WKY / Q000378:metabolism*; D013154:Spleen / Q000737:chemistry; D015032:Zinc / Q000032:analysis* / Q000097:blood
D015032:Zinc