Serum thymic factor as a radioprotective agent promoting survival after X-irradiation.
Serum thymic factor (FTS, zinc-free thymulin) protected mice from death after whole-body X-irradiation. It was significantly radioprotective even when administered after irradiation, but it was more effective when administered both before and after irradiation. The protective effect appears to be due to the enhancement of hematologic recovery in the animals.
Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Mobara, Japan.
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Kobayashi
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Abe
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Awaya
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Inano
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Shikita
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D015996:Survival Rate; D013935:Thymic Factor, Circulating / Q000008:administration & dosage / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating