Modulation of hippocampal primed burst potentiation by anesthesia.
This study demonstrates that the anesthetics urethane and pentobarbital differentially affect a low threshold form of long-lasting synaptic plasticity, termed primed burst (PB) potentiation, in the CA1 area of rat hippocampus. PB potentiation was generated by the delivery of a 5-pulse patterned stimulus train, consisting of one priming pulse followed 170 ms later by a burst of 4 pulses at 200 Hz. PB potentiation could not be reliably generated in urethane-anesthetized rats unless stimulus currents were raised to 150% of baseline levels during the stimulus train. In pentobarbital-anesthetized rats, PB potentiation could always be evoked at baseline stimulus intensities. Differences between the anesthetics which could contribute to their varying effects upon PB potentiation are discussed.
Engstrom
D A
DA
Medical Research Service, Veterans Administration Medical Center, Denver, CO 80220.
Bennett
M C
MC
Stevens
K E
KE
Wilson
R L
RL
Diamond
D M
DM
Fleshner
M
M
Rose
G M
GM
D000200:Action Potentials / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane / Q000494:pharmacology*
D014520:Urethane; D010424:Pentobarbital; D003345:Corticosterone