Abolition by omeprazole of aspirin induced gastric mucosal injury in man.
This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and their complications in patients taking aspirin and other non-steroidal anti-inflammatory drugs.
University Department of Therapeutics, University Hospital, Nottingham.
T K
TK
Daneshmend
A G
AG
Stein
N K
NK
Bhaskar
C J
CJ
Hawkey
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004311:Double-Blind Method; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D009853:Omeprazole; D001241:Aspirin