[Uncomplicated attack of malaria in an area with high resistance to chloroquine. I. Evaluation of a short treatment with quinine].
The good results achieved in the treatment of malaria with a 7 and 5 days one of quinine (orally dose 8 mg/kg/8 h), incited the authors to try a 3 days long treatment at the same dose. They experimented this protocol on hospitalised children. All patients were free of parasites at day 7 with an average residual concentration quinine of 2.7 +/- 0.8 mg/l. Among the 7 patients with malaria at day 14, 4 didn't require another treatment and 2 presented new infestation. 50% of plasmodial isolated strains were chloroquine resistant and 40% amodiaquine resistant. The efficiency of this protocol could be in favour of its larger use.
Jambou
R
R
OCEAC B. P., Yaoundé.
Abissegue
B
B
Gelas
H
H
Ghipponi
P M
PM
Farinotti
R
R
Le Bras
J
J
Hengy
C
C
D000293:Adolescent; D000818:Animals; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000627:therapeutic use*
D002738:Chloroquine; D011803:Quinine
L'accès palustre simple en zone de haut niveau de résistance à la chloroquine. I. Evaluation d'un traitement court par la quinine.