[Environmental factors in the etiology of Parkinson's disease].
We examined the role of the environment in the development of Parkinson's disease (PD). A group of 42 parkinsonians have been compared with a group of 84 matched controls. The epidemiological study (1987-1989) covered the territory of the Community Health Department of Valleyfield, in southern Quebec (Canada). Odds ratio adjusted for age and sex were calculated for seven environmental factors. A decreased risk for PD was associated with residence in rural areas (OR: 0.31; p less than or equal to 0.05) and residence near industry or mining (OR: 0.15; p less than or equal to 0.05). An increased risk for PD seems to be associated with occupational exposure to the three metals Mn, Fe and Al (OR: 2.28; p = 0.07) especially when the duration of exposure is longer than 30 years (OR: 13.64; p less than or equal to 0.05). Other environmental factors not found to be associated with PD were: pesticides manipulation, farm work, industrial work and well water consumption.
Zayed
J
J
Département de médicine, Faculté de l'éducation permanente, Université de Montréal, Québec, Canada.
Ducic
S
S
Campanella
G
G
Panisset
J C
JC
André
P
P
Masson
H
H
Roy
M
M
D004777:Environment; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects; D008906:Mining; D016273:Occupational Exposure; D010300:Parkinson Disease / Q000453:epidemiology / Q000209:etiology*; D011792:Quebec; D012307:Risk Factors; D012424:Rural Population; D014505:Urban Population; D014881:Water Supply / Q000032:analysis
D008670:Metals
Facteurs environnementaux dans l'étiologie de la maladie de Parkinson.