Severe hypoxia activates lipid peroxidation in the rat brain.
The level of lipid peroxides, concentration of lactic acid in the blood and brain tissue homogenates were measured in rats under hypoxic hypoxia and hemorrhage. Significant correlation was found between the O2 supply-consumption ratio, the concentration of lactate and the level of lipid peroxides. It is suggested that the peroxidation process is activated by hypoxia.
A.A. Bogomoletz Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev.
T D
TD
Minyailenko
V P
VP
Pozharov
M M
MM
Seredenko
D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D008315:Malondialdehyde; D010100:Oxygen