The distribution of renin-containing cells in kidneys with renal artery stenosis--an immunocytochemical study.
In 10 kidneys removed for hypertension due to renal artery stenosis, the histological appearances varied from negligible ischaemic damage to end-stage ischaemic atrophy. We stained the renin-containing cells in tissue sections using an antiserum to pure human renin and an immunoperoxidase technique. In all kidneys there was hyperplasia of the renin-containing cells both in juxtaglomerular apparatuses (JGAs) and in arteries outside the JGA, where these cells extended proximally as far as the interlobular arteries. We mapped the distribution of renin-containing cells and found them in all zones of the renal cortex; in three kidneys they were predominantly in the superficial cortex; in four they were distributed more evenly throughout the width of the cortex; but in three kidneys the normal gradient was reversed, with most of the cells being in the juxtamedullary cortex and, in two of the cases, little or no stainable renin in the superficial cortical JGAs. We suggest that these abnormalities in the distribution of renin-containing cells could affect both the pattern of intrarenal blood flow and the site in the kidney at which secreted renin enters the blood.
Graham
P C
PC
Department of Morbid Anatomy, King's College Hospital, London, UK.
Stewart
H V
HV
Downie
I
I
Lindop
G B
GB
D006801:Humans; D007150:Immunohistochemistry; D007511:Ischemia / Q000473:pathology; D007606:Juxtaglomerular Apparatus / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000098:blood supply; D007672:Kidney Cortex / Q000378:metabolism; D012078:Renal Artery Obstruction / Q000378:metabolism* / Q000473:pathology; D012083:Renin / Q000378:metabolism*
D012083:Renin