Microbial mutagenicity screening of natural flavouring substances.
Sixty-five commercial samples of natural flavouring substances were screened for mutagenicity in the Salmonella typhimurium strains TA98 and TA100. The results obtained demonstrated a significant mutagenic activity in onion and garlic extracts, both in assays with and without exogenous metabolic activation. The response pattern obtained in tester strains with different genetic backgrounds suggests the involvement of mutagenic flavone(s) in the genotoxic effects observed.
Istituto Superiore di Sanità, Rome, Italy.
R
R
Crebelli
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G
Aquilina
L
L
Conti
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A
Carere
D000490:Allium; D005421:Flavoring Agents / Q000633:toxicity*; D005737:Garlic; D009152:Mutagenicity Tests; D009154:Mutation; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D012486:Salmonella typhimurium
D005421:Flavoring Agents; D010936:Plant Extracts