Sunscreening agent intolerance: contact and photocontact sensitization and contact urticaria.
Reports in the literature of sensitization associated with many commonly used sunscreening agents including p-aminobenzoic acid (PABA), PABA derivatives, anthranilates, salicylates, cinnamates, benzophenones, and dibenzoylmethane derivatives are reviewed. Several of these case reports involved subjects with various photodermatoses, implicating enhanced sensitivity of the patient's skin to both light and chemicals. Despite the widespread use of sunscreens, the small number of published reports of contact and photocontact sensitization to these agents suggests that either such sensitization is less than commonly perceived or is underreported. Establishment of a registry for reporting adverse effects associated with sunscreening agents would help to characterize the incidence of sensitization.
Clinical Research and Development Department, Herbert Laboratories, Irvine, CA.
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Dromgoole
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Maibach
D010129:4-Aminobenzoic Acid / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000209:etiology*; D005079:Excipients / Q000009:adverse effects; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000009:adverse effects*; D014481:United States; D014581:Urticaria / Q000139:chemically induced*; D062366:para-Aminobenzoates
D005079:Excipients; D013473:Sunscreening Agents; D062366:para-Aminobenzoates; D010129:4-Aminobenzoic Acid; C041981:padimate-O