Human globin locus activation region (LAR): role in temporal control.
A region of DNA located far upstream of the human beta-globin locus is critically involved in the regulation of the beta-globin gene family. Recent experiments in transgenic mice suggest that switching from fetal to adult globin gene expression during human development results from competition among individual globin gene family members for interaction with sequences in this region. The phenotypes of patients with defined hemoglobinopathies support this hypothesis.
Department of Biochemistry, School of Medicine, University of Alabama, Birmingham 35294.
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Townes
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Behringer
D000818:Animals; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D005810:Multigene Family; D010641:Phenotype
D005914:Globins