Tremor in Parkinson disease: acute response to oral levodopa.
A single blind placebo-controlled study has been performed in order to investigate objectively the acute tremorolytic effect of oral L-Dopa in ten parkinsonians chronically treated with L-Dopa. Finger tremor was assessed by means of a computerized accelerometer method, at rest and during maintenance of a fixed posture. Both resting and postural tremor were significantly influenced by L-Dopa. An "acute test" with oral L-Dopa, especially when different tremor components are investigated, may be useful for identifying objectively parkinsonians whose tremor does not respond to drug therapy or shows a deterioration of drug-responsiveness.
Istituto di Scienze Neurologiche, I Facoltà di Medicina, Università di Napoli.
G
G
Tedeschi
E
E
Sasso
R W
RW
Marshall
V
V
Bonavita
D000284:Administration, Oral; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D011187:Posture; D012146:Rest; D013997:Time Factors; D014202:Tremor / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D007980:Levodopa