Experimental models of autoimmune diseases.
Several experimental models of autoimmune diseases have been studied which often mimic the human situation. Autoreactive T cells that emerge either spontaneously or after immunization have been identified in several situations. The main lesson from these models is that these autoreactive T cells are negatively controlled in the normal situation and that a defect either inherited or acquired in this regulatory circuit is responsible for autoimmunity.
Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
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D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008627:Mercuric Chloride / Q000494:pharmacology; D009395:Nephritis, Interstitial / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007519:Isoantigens; D008627:Mercuric Chloride