[Breast carcinoma in situ. Diagnostic and therapeutic aspects with special reference to growth patterns].
The probability of developing in situ carcinoma has been calculated at about 25%, while the cumulative risk of having the diagnosis established is estimated at less than 1%. In situ carcinoma in its pure form constitutes up to about 6% of all newly diagnosed breast cancers in clinical series, whereas its share in the most thorough mammographic screening series ranges from 8 to 16%. This excess in diagnosis comprises, in particular, the ductal type, primarily its most aggressive forms. To-day in situ cancer occurs chiefly as non-palpable lesions demonstrated by mammography or as minor changes discovered accidentally by the pathologist. A more recent classification based upon histological growth patterns is described. The advantage of classifying according to growth pattern bears a good correlation to clinical presentation, extent of surgery and prognosis. The treatment of in situ carcinoma lacks a rational basis. Therapy should therefore be kept within the framework of prospective protocols. Various treatment modalities are described with reference to the most important multicenter trials.
Odense Sygehus, kirurgisk afdeling K, patologisk institut og røntgendiagnostisk afdeling.
M
M
Blichert-Toft
J
J
Andersen
U
U
Dyreborg
D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans
Carcinoma in situ mammae. Diagnostiske og terapeutiske aspekter med saerlig reference til vaekstformer.