[An autopsy case of extramural malignant leiomyoblastoma of the stomach with ovarian cancer: an immunohistochemical study].
The subject was an 85-year-old woman, who had been diagnosed as having an ovarian cancer and carcinomatous peritonitis and had been treated conservatively. She subsequently died from respiratory and renal insufficiency, and the autopsy that followed revealed that her pelvic cavity had been filled by a tumorous mass that size of a child's head. Histologically, the tumor was a serous cystadenocarcinoma of the ovary. Moreover another tumor, also the approximate size of a child's head, was found sited extramurally, beneath the posterior wall mucosa of the stomach body. Histological inspection of this tumor revealed a proliferation of round oval, and spindle-shaped tumor cells. A vacuolation of the cytoplasms and karyomitosis to the extent of 10/50 HPF also were observed. Based on the findings of being positive for Vimentin and a negative EMA, this tumor was diagnosed as being a malignant leiomyoblastoma of the stomach smooth muscle. The leioblastoma is a relatively uncommon neoplasm, and recent advances in immunohistochemical staining have indicated that some of these tumors are not only of smooth muscle derivation but also of nerve origin. Therefore, this tumor, given its morphological characteristics, had been generalized in this case as a gastric stromal tumor, and with negative findings for Desmin and S-100 protein, as well as positive for Vimentin.
2nd Dept. of Pathology, Kobe Univ. School of Med.
A
A
Gotoh
T
T
Fujimori
A
A
Takenaka
D
D
Hirayama
K
K
Satonaka
M
M
Horio
S
S
Kitazawa
S
S
Maeda
S
S
Kamidono
D000368:Aged; D000369:Aged, 80 and over; D003536:Cystadenocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007889:Leiomyoma / Q000032:analysis / Q000276:immunology / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D009378:Neoplasms, Multiple Primary; D010051:Ovarian Neoplasms / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000032:analysis / Q000276:immunology / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin