Is nifedipine phototoxic?
Circumstantial evidence of phototoxicity of nifedipine is poor, being based only on uncontrolled clinical evidence. The authors have assessed nifedipine phototoxicity in vitro by photohemolysis and Candida albicans tests and found it measurable at 10 and 100 micrograms/ml. These dosages exceed the 0.1 microgram/ml blood levels that are usually attained in vivo.
Guarrera
M
M
Department of Dermatology, University of Genoa, Italy.
Parodi
A
A
Rebora
A
A
D000368:Aged; D002176:Candida albicans / Q000528:radiation effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D010782:Photolysis; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D014466:Ultraviolet Rays
D009543:Nifedipine