[Thrombocyte growth factor].
PDGF is one of the principal mitogens for cultured cells of mesenchymal origin. Apart from aggregated platelets PDGF can be secreted by a number of cells. There is a striking homology between the amino-acid sequence of PDGF and that of a transforming protein of simian-sarcoma virus. PDGF is an important chemotactic protein for cells implicated in wound healing. Furthermore, recent publications suggest a possible role in the pathogenesis of several diseases. This article summarizes studies and recent findings on the structure, biology, and functional role of PDGF.
Medizinische Universitätsklinik und Poliklinik, Abteilung Innere Medizin III-Hämatologie/Onkologie, Ulm.
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Buck
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Montenarh
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000737:chemistry* / Q000502:physiology
D010982:Platelet-Derived Growth Factor
Thrombozyten-Wachstumsfaktor.