The transitional circulation: physiology and anesthetic implications.
Over the past decade, several aspects of the physiology of the transitional circulation have been elucidated. The transitional circulation may be viewed as a process divided into four phases. The concept of these phases underscores the fact that the normal transitional circulation should be viewed as an orderly process and not a single event. Within these phases, several mechanisms seem to be involved in the control of pulmonary vascular resistance (PVR). Yet even these mechanisms do not completely explain the process of the normal transition, and very little is understood about why the transition occasionally fails. No doubt other as yet undescribed mechanisms also play a role. Much work remains to be done in the study of the normal and abnormal transitional circulation. The profound hypoxia that characterizes infants with failed transitional circulation from any cause is due to a persistently high PVR, causing right-to-left shunting at the ductal and foramental levels. Clinical care of these infants is based on efforts to simultaneously decrease PVR and increase systemic vascular resistance (SVR). Appropriate measures include the use of supplemental oxygen, hyperventilation, alkalinization, and sedation to decrease PVR and intravenous (IV) fluids and pressors to increase SVR. The rapidly fluctuating nature of the physiologic processes that cause failure of the transitional circulation must be kept in mind when caring for these infants, both during initial stabilization in the delivery room and while administering anesthesia for surgical repair of congenital defects.
Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195.
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Clarke
D000768:Anesthesia, General / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000503:physiopathology* / Q000628:therapy