Cigarette smoking increases gastric luminal prostaglandin F2 alpha and thromboxane B2 in healthy smokers.
Pentagastrin-stimulated gastric luminal prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, PGF2 alpha and thromboxane B2 (TxB2) were measured using a second antibody solid-phase enzyme immunoassay before, during and after cigarette smoking in healthy smokers. Smoking significantly increased PGF2 alpha and TxB2 concentration and output; in contrast no significant changes were found for PGE2 and 6-keto-PGF1 alpha levels. In addition, cigarette smoking caused a significant reduction in gastric juice volume and acid output but did not alter intragastric acidity. These findings may suggest a possible role of prostanoids in the response of the stomach to cigarette smoking.
Department of Clinical Pathophysiology, University of Florence, Italy.
P
P
Fedi
A
A
Calabrò
B
B
Orsini
S
S
Milani
P
P
Zacchi
G
G
Salvadori
C
C
Surrenti
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012907:Smoking / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D015232:Dinoprostone