[An undifferentiated carcinoma of the esophagus--a case of an elderly patient].
Reported is the case of an undifferentiated carcinoma of the esophagus that had developed in an 80-year-old man. This polypoid a tumor was an elevated nodular mass, 9 x 5 cm in diameter, that had invaded the muscle layer. Microscopically, the tumor was composed of small polygonal cells with hyperchromatic nuclei that were unaffected by either Grimelius or PAS staining. An epidermal growth factor immunoreactivity was found in a few of the tumor cells. Ultrastructurally, the tumor cells had abundant ribosomes, a rough endoplasmic reticulum, and mitochondria. Coamplification of HST-1 or INT-2 genes was not observed by slot blot analysis. The patient is now well with no evidence of a tumor recurrence or a distant metastasis 11 months after surgery.
Ito
M
M
1st Dept. of Pathology, Hiroshima Univ. School of Med.
Ito
H
H
Inokuchi
C
C
Tahara
E
E
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male
D014408:Biomarkers, Tumor