Efficacy and toxicity of 5-fluorouracil and folates in advanced colon cancer.
From February 1987 to December 1988, 34 patients with histologically confirmed advanced colorectal carcinoma were entered in a phase II trial with 5-fluorouracil (5-FU) and folinic acid, for evaluation of treatment effectiveness and toxicity. Our data confirmed that the association 5-FU and folates represents an effective and moderately tolerated palliative treatment, with diarrhea being the only dose-limiting toxicity.
Cortesi
E
E
Dipartimento di Medicina Sperimentale, Università La Sapienza, Rome, Italy.
Aschelter
A M
AM
Gioacchini
N
N
Pellegrini
A
A
Frati
L
L
Ficorella
C
C
Mazzei
N
N
Marchetti
P
P
D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*
D002955:Leucovorin; D005472:Fluorouracil