Macrophage hyperreactivity to endotoxin induced by streptococcal pyrogenic exotoxin in rabbits.
Pretreatment of rabbits with streptococcal pyrogenic exotoxin (SPE) resulted in an enhancement of their febrile response to subsequent endotoxin challenge. This suggested that SPE may enhance the macrophage capacity to respond to endotoxin in vivo to produce an endogenous pyrogen. It was also demonstrated that peritoneal macrophages derived from SPE-treated rabbits exhibited hyperreactivity to endotoxin in vitro as assessed by endotoxin-induced increase in glucose consumption. These data indicate that SPE has the ability to enhance macrophage reactivity to endotoxin.
Murai
T
T
National Institute of Hygienic Sciences, Osaka Branch, Japan.
Ogawa
Y
Y
Kawasaki
H
H
D000818:Animals; D001426:Bacterial Proteins; D004357:Drug Synergism; D004731:Endotoxins / Q000494:pharmacology*; D005098:Exotoxins / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins; D011749:Pyrogens / Q000378:metabolism; D011817:Rabbits; D013297:Streptococcus pyogenes
D001426:Bacterial Proteins; D004731:Endotoxins; D005098:Exotoxins; D008565:Membrane Proteins; D011749:Pyrogens; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; D005947:Glucose