Influence of adrenaline on the onset time of lignocaine anaesthesia.
Rat sciatic nerves were employed to investigate the influence of adrenaline on the onset time for anaesthetic blockade induced by 2 per cent lignocaine HCl. The addition of adrenaline at three concentration levels to 2 per cent lignocaine HCl solutions delayed the onset time for conduction blockade.
Department of Oral and Maxillofacial Surgery, University Dental Hospital of Manchester, UK.
V O
VO
Falaiye
J P
JP
Rood
D000818:Animals; D004347:Drug Interactions; D004558:Electric Stimulation; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009407:Nerve Block; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects; D013997:Time Factors
D008012:Lidocaine; D004837:Epinephrine