Cellular mechanism for ischemic ventricular arrhythmias.
Two of the major ionic abnormalities found early in ischemia are (a) loss of potassium with an increase in the extracellular potassium ion concentration and (b) an increase in free cytosolic calcium. Both of these ionic abnormalities can powerfully predispose to the development of arrhythmias.
Opie
L H
LH
Medical Research Council/University of Cape Town Ischemic Heart Disease Research Unit, University of Cape Town Medical School, South Africa.
Clusin
W T
WT
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D003327:Coronary Disease / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D006352:Heart Ventricles; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D011188:Potassium; D002118:Calcium