Tumour cell purging for autologous bone marrow transplantation.
Interest in autologous bone marrow transplantation as treatment for haematological disease has increased considerably in the past 10 years. Remission bone marrow can be collected, stored until the patient has received myeloablative therapy, then re-infused. A disadvantage of this form of treatment is the possibility of re-infusion of residual malignant cells. The methods currently available for removal of neoplastic cells from autologous marrow prior to transplantation are reviewed.
Trickett
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Cell Biology Unit, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia.
D016026:Bone Marrow Transplantation; D002469:Cell Separation / Q000379:methods*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007158:Immunologic Techniques; D007938:Leukemia / Q000473:pathology* / Q000601:surgery; D014182:Transplantation, Autologous