Differential roles of multiple adhesion molecules in cell migration: granule cell migration in cerebellum.
The migration of cerebellar granule cells from the external granular layer to the internal granular layer is mediated by the radical Bergmann glial fiber. Recent works have shown that cell adhesion molecules, extra-cellular matrix proteins and proteolytic enzymes or their activators are involved in this process. Immuno-localization studies showed differential temporal and spatial expression patterns of different adhesion molecules, their isoforms, and post-translational modification during different stages of granule cell migration. Functional perturbation experiments using cerebellar explant cultures demonstrated that several adhesion molecules as well as plasminogen activator are involved in granule cell migration and are required in different stages. Other systems used to study granule cell migration including dissociated microwell cultures and granule cell deficient mouse mutants are discussed in the context of adhesion molecules. The results accumulated so far suggest that the migration of granule cells is a complex process in which the cooperation of a group of molecules with different functions, some for adhesion some for de-adhesion, are required to fulfill the different needs during the migratory course.
Chuong
C M
CM
Department of Pathology, University of Southern California, Los Angeles 90033.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement; D002531:Cerebellum / Q000166:cytology* / Q000254:growth & development; D006801:Humans
D015815:Cell Adhesion Molecules