[The postresuscitation changes in the permeability of the hemato-encephalic barrier and their possible pathogenetic significance].
Experiments were conducted on rats with temporary (10-min) clamping of the thoracic vascular bundle and subsequent resuscitation to study the permeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period. Mild increase of BBB permeability was detected 3 minutes after the beginning of recirculation. Permeability increased markedly in 24 hours and continued growing by the 72nd hour. At a 1-3-hour interval in recirculation the BBB was closed. The obtained results disclose the mechanisms of the development of autoimmune cerebral disorders in an organism that experienced cardiac arrest and resuscitation.
Gannushkina
I V
IV
Weinrauder-Semkow
G
G
Mutuskina
E A
EA
Gurvich
A M
AM
Mossakowski
M J
MJ
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000502:physiology*; D001927:Brain Diseases / Q000209:etiology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology; D002463:Cell Membrane Permeability / Q000502:physiology; D005455:Fluorescent Antibody Technique; D006323:Heart Arrest / Q000503:physiopathology; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects; D013997:Time Factors
D001798:Blood Proteins; D007136:Immunoglobulins
Postreanimatsionnye izmeneniia pronitsaemosti gematoéntsefalicheskogo bar'era i ikh vozmozhnoe patogeneticheskoe znachenie.