Winter depression responds to an open trial of tranylcypromine.
Seasonal affective disorder (SAD) is a disturbance of mood bearing a fixed relationship to season. Winter depression is characterized by the onset of a depressive syndrome in the fall or winter and spontaneous remission in the spring, this condition responds to full-spectrum, bright artificial light. In the first study assessing responsiveness of winter depression to a standard pharmacologic treatment for depression, the authors found that 14 patients meeting National Institute of Mental Health criteria for winter depression responded to treatment with tranylcypromine.
Department of Psychiatry, Ohio State University, Columbus.
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Dilsaver
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Jaeckle
D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D011569:Psychiatric Status Rating Scales; D012621:Seasons; D014191:Tranylcypromine / Q000627:therapeutic use*
D014191:Tranylcypromine