[The insulin receptor function of mononuclear leukocytes in pregnant women with diabetes mellitus].
Investigation of the insulin-binding activity of insulin receptors (IR) in insulin treated pregnant women with insulin dependent diabetes mellitus with different requirement in insulin has shown that insulin-dependent diabetes in pregnant women in characterized by heterogeneity. Insulin therapy gets to normal the activity of insulin receptors in patients with diabetes mellitus with an increased affinity to IR, and causes no increase in the level of IR in patients in whom it was not raised. Insulin-binding activity in the latter may be associated with metabolic derangement caused by insulin insufficiency.
Mikaelian
N P
NP
Kniazev
Iu A
IuA
Bespalova
V A
VA
Kirbasova
N P
NP
Petrukhin
V A
VA
D001786:Blood Glucose / Q000032:analysis; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000097:blood; D007333:Insulin Resistance; D007457:Iodine Radioisotopes; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000188:drug therapy; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin
Sostoianie insulinovykh retseptorov mononuklearov u beremennykh zhenshchin, bol'nykh sakharnym diabetom.