Acute effect of intrapulmonary enalaprilat in ten patients with severe pulmonary hypertension due to toxic oil syndrome.
Ten patients with severe pulmonary hypertension due to Toxic Oil Syndrome underwent cardiac catheterization to analyse the acute effect of intrapulmonary injection of 1.25 mg of enalaprilat. Haemodynamic parameters were obtained at basal state, 15, 30, 45 and 60 minutes after administration of the drug. Enalaprillat did not produce any statistically significant changes in pulmonary pressures and resistances or cardiac output. This lack of response is unknown but may be related to the presence of endothelial damage and fixed pulmonary vascular lesions observed at autopsy in three patients.
Cardiology Service, Hospital 12 de Octubre, Madrid, Spain.
C
C
Gomez Pajuelo
M A
MA
Gomez Sanchez
M
M
Alonso Gutierrez
F
F
Lombera Romero
R
R
Gabriel Sanchez
A
A
Fernandez Cruz
C
C
Saenz de la Calzada
D004656:Enalapril / Q000008:administration & dosage*; D005229:Fatty Acids, Monounsaturated; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000188:drug therapy; D007269:Injections, Intra-Arterial; D010938:Plant Oils / Q000009:adverse effects*; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D000074262:Rapeseed Oil; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D013577:Syndrome; D014655:Vascular Resistance / Q000187:drug effects
D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D004656:Enalapril