[Immune response during experimental periodontitis in mice].
Four groups of mice, each of a different genotype, were orally inoculated with Actinomyces viscosus. The resulting periodontal bone loss was monitored and the isotype specific anti-A. viscosus serum humoral immune responses measured by ELISA. Maximum periodontal bone loss occurred in all genotypes with inoculation of 1.6 x 107 colony forming units of A. viscosus. IgG and IgM isotype levels increased with inoculation of 1.6 x 107 colony forming units of A. viscosus in three of the four groups, indicating that IgA may be important in producing periodontal bone loss.
Université d'Edimburgh, Royaume-Uni.
A
A
Gilbert
D
D
Wray
J
J
Charon
D000190:Actinomyces / Q000302:isolation & purification; D000818:Animals; D000907:Antibodies, Bacterial; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000235:genetics*; D001862:Bone Resorption / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010518:Periodontitis / Q000276:immunology* / Q000382:microbiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Réponse immunitaire au cours des parodontitis expérimentales cehz la souris.