[Effect of interferon on the course of experimental E coli-induced pyelonephritis].
The effect of the type I interferon on the development and process of experimental pyelonephritis caused by E. coli was studied on mice weighing 12 to 14 g. Interferon was administered intraperitoneally in a dose of 1000 units on days 3 and 7 of the disease. It was shown that the administration of the type I interferon to the mice with experimental pyelonephritis promoted rapid elimination of bacteria from the kidneys, prevented their penetration to the contralateral (intact) kidney, prevented marked macro- and microscopic damages in the kidneys, lowered the intensity of the inflammatory reaction, and increased the phagocytic activity of neutrophils and the number of the E-rosette-forming lymphocytes in the thymus. The data provided experimental grounding for clinical trials of interferon preparations in treatment of bacterial pyelonephritis.
Rudenko
A V
AV
Maĭdannik
V G
VG
Pavlenko
V A
VA
Spivak
N Ia
NIa
Romanenko
A M
AM
Ishchenko
E M
EM
Glebova
L P
LP
Bavina
E N
EN
D000276:Adjuvants, Immunologic; D000818:Animals; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D007370:Interferon Type I / Q000627:therapeutic use*; D007682:Kidney Pelvis / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011704:Pyelonephritis / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D007370:Interferon Type I
Vliianie interferona na techenie eksperimental'nogo kolibatsilliarnogo pielonefrita.