[Toxicity studies of the incubated chicken egg. With special reference to the extra-embryonal vascular systems].
The use of the incubated chicken egg as a test system to evaluate the effects of hazardous substances is reported. Several different methods to carry out toxicological as well as teratological studies are mentioned. Experimental toxicity testing and basic pathology studies on the extra-embryonal blood vessel systems of the chick embryo (yolk sac system and chorio-allantoic membrane) are described in detail. In this field, the application of the yolk sac system has some advantages compared with the chorio-allantoic membrane. Finally, the use of so-called "alternative methods" and the replacement of the Draize-test and LD50- studies are discussed.
Medizinischen Institut für Umwelthygiene, Heinrich-Heine-Universität Düsseldorf.
M
M
Rosenbruch
D000482:Allantois / Q000098:blood supply*; D000818:Animals; D002196:Capillaries / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005321:Extraembryonic Membranes / Q000098:blood supply*; D015386:Hazardous Substances / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*; D015017:Yolk Sac / Q000098:blood supply*
D015386:Hazardous Substances; D013723:Teratogens
Toxizitätsuntersuchungen am bebrüteten Hühnerei. Unter besonderer Berücksichtigung der extraembryonalen Gefässsysteme.