[A concept of limiting genetic factors of expression, organization, and evolution].
Elicitation and analysis of limiting genetic factors represent convenient method for approximate description of complex molecular-genetic systems. In sequential metabolic ways, the limiting is based on the minimum of catalytic activity, in parallel ones--on the maximum activity. In polygenic systems, the expressing polygenes affect always the limiting oligogenes. Limiting genes are only available to selection on the population level, the non-limiting genes being neutrally evolving. This result eliminates the acuteness of the Haldane's dilemma. The complex genetic systems could be quickly evolving by relay-race principle with sequentional change of limiting genes and without violation of Haldane's dilemma. The limiting factors of organization which restrict the possibilities of some special evolutionary directions have the key role in evolution. These limits were historically overcome by acceptance of evolutionary acquirements of wide usage. The sequence of such limits and acquirements was assumed as a basis of "scenario" of Prebiological and Biological Molecular Evolution. The concept is illustrated by some examples and results of theoretical analysis.
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Ratner
D000818:Animals; D005075:Biological Evolution; D015870:Gene Expression; D006801:Humans; D008957:Models, Genetic; D008962:Models, Theoretical
Kontseptsiia limitiruiushchikh geneticheskikh faktorov ékspressii, organizatsii i évoliutsii.