Growth in children following kidney transplantation.
Growth was assessed in children following 128 separate kidney transplants using a generalized growth curve multivariate analysis. The height standard deviation score was the dependent variable. Time since transplant, prednisone dosage, and creatinine clearance were the independent variables. For the purposes of comparison patients were grouped according to sex, race, age at transplantation, initial allograft function, acute rejection episodes and the use of cyclosporin A. Patient's height standard deviation scores tended to increase negatively after transplantation. However, children who received transplants before their 7th birthday, with initial allograft function greater than 60 ml/min per 1.73 m2, exhibited "catch-up" growth. Height standard deviation scores positively improved in males but not in females, as prednisone dosage was decreased. Height standard deviation scores became more negative as renal function decreased after transplantation. Changes in renal function produced the greatest effect upon height in black children, children less than 7 years, and males.
Department of Pediatrics, University of Florida, Gainesville 32610-0296.
R S
RS
Fennell
M
M
Moles
A
A
Iravani
R D
RD
Walker
W
W
Pfaff
R J
RJ
Howard
R C
RC
Capen
R L
RL
Carter
G A
GA
Richard
D000293:Adolescent; D000367:Age Factors; D002648:Child; D003524:Cyclosporins / Q000009:adverse effects; D005260:Female; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D008775:Methylprednisolone