Why are proteins O-glycosylated?
The O-linked oligosaccharides of glycoproteins are usually clustered within heavily glycosylated regions of the peptide chain. Steric interactions between carbohydrate and peptide within these clusters induce the peptide core to adopt a stiff and extended conformation and this conformational effect appears to represent a major function of O-glycosylation.
Jentoft
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Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.
D000818:Animals; D006023:Glycoproteins / Q000378:metabolism* / Q000502:physiology; D006031:Glycosylation; D011487:Protein Conformation
D006023:Glycoproteins