Glutathione-dependent protection against oxidative injury.
Functions of GSH in detoxication during radical-induced injury in specific pathological and toxicological conditions are discussed. GSH protects against oxidative damage in systems that scavenge radicals, eliminate lipid peroxidation products, preserve thiol-disulfide status of proteins, and repair oxidant damage. Several factors which affect cellular GSH homeostasis can affect these functions, including nutritional status, hypoxia and pharmacological intervention. Evidence from a variety of pathological and toxicological conditions, e.g. ischemia-reperfusion injury, chemically induced oxidative injury, radiation damage, aging, and degenerative diseases, indicate that GSH is a primary component of physiological systems to protect against oxidant and free-radical-mediated cell injury.
Shan
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Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.
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Jones
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D000818:Animals; D005609:Free Radicals; D005978:Glutathione / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D005609:Free Radicals; D005978:Glutathione; D010100:Oxygen