Sequence determination of actagardine, a novel lantibiotic, by homonuclear 2D NMR spectroscopy.
By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class.
Kettenring
J K
JK
Merrell Dow Research Institute, Lepetit Research Center, Varese, Italy.
Malabarba
A
A
Vékey
K
K
Cavalleri
B
B
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001430:Bacteriocins; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010455:Peptides; C012993:gardimycin