Characterization of the antibody response in Corynebacterium jeikeium septicaemias.
Corynebacterium jeikeium causes septicaemia in neutropenic patients usually after colonizing intravenous lines. This paper reports the results of immunoblotting sera from 14 patients with a C. jeikeium septicaemia. Recovery from the septicaemia was associated with production of both IgM and IgG against antigenic bands of 50, 52 and 110 kDa. Antibody against the 110 kDa band was present in controls but the antibody against the 50 and 52 kDa was specific to those patients who had on-going or previous C. jeikeium infection. A case of C. jeikeium endocarditis is also presented and here recovery was associated with seroconversion to the 50 and 52 kDa bands.
Department of Molecular Microbiology, Manchester University Medical School.
I
I
Clark
J P
JP
Burnie
A P
AP
Coke
R C
RC
Matthews
B A
BA
Oppenheim
D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D002408:Catheters, Indwelling; D003352:Corynebacterium / Q000276:immunology*; D003354:Corynebacterium Infections / Q000150:complications / Q000276:immunology*; D004697:Endocarditis, Bacterial / Q000150:complications / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D009503:Neutropenia / Q000150:complications*; D018805:Sepsis / Q000150:complications / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M