[The reactogenicity and immunological efficacy of a Klebsiella vaccine in donors].
Klebsiella vaccine, when injected subcutaneously to donors, proved to be faintly reactogenic and safe. The injection of the vaccine had no effect on changes in the morphological composition of peripheral blood and on liver function. In persons with the initially low content of IgG an increase in this characteristic was observed after immunization. No changes in the synthesis of IgE occurred in healthy donors under the influence of immunization. The vaccine was shown to be immunogenic when introduced according to immunization schedules comprising 3 and 5 injections, the titer of Klebsiella antibodies increasing 3- to 5-fold.
Kurbatova
E A
EA
Egorova
N B
NB
Dubova
V G
VG
Davatdarova
G M
GM
Lipats
A A
AA
Gervazieva
V B
VB
Kaverina
K G
KG
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000009:adverse effects* / Q000276:immunology; D001782:Blood Donors; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007136:Immunoglobulins / Q000032:analysis; D007279:Injections, Subcutaneous; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007136:Immunoglobulins
Izuchenie reaktogennosti i immunologicheskoĭ éffektivnosti klebsielleznoĭ vaktsiny na donorakh.