[Relationship of the left ventricular wall thickness to the degree of late microvascular complications in diabetes mellitus type I].
Left-ventricular wall thickness, measured by echocardiography, was determined in 111 normotensive diabetics (63 men and 48 women; mean age 26 +/- 9 years; diabetes duration 13.5 +/- 6.2 years) and 91 comparable control subjects. The interventricular septum was significantly thicker in diabetics than in controls: systolic 13.3 +/- 2.3 mm, diastolic 9.2 +/- 2.2 mm vs. systolic 12.5 +/- 2.1 mm and diastolic 8.9 +/- 1.7 mm (P less than 0.05). Posterior wall thickness measurements were: systolic 15.8 +/- 2.2 mm vs 14.6 +/- 2.0 mm (P less than 0.001), diastolic 9.5 +/- 1.8 mm vs 8.4 +/- 1.3 mm (P less than 0.01). Left-ventricular wall thickness increased stepwise with increasing severity of microvascular complications (retinopathy, nephropathy, neuropathy). There was a moderately close correlation between blood pressure values and the degree of microvascular complications (r = 0.49, P less than 0.01). These correlations indicate that increases in wall thickness are diabetes specific, but may be influenced by the level of blood pressure.
Abteilung Innere Medizin IV, Universität Ulm.
A
A
Schmidt
G
G
Grossmann
H
H
Hauner
R
R
Emmert
M
M
Stauch
V
V
Hombach
D000328:Adult; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000473:pathology*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology; D006346:Heart Septum / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology*
Abhängigkeit der linksventrikulären Wanddicken vom Grad der mikrovaskulären Spätkomplikationen bei Diabetes mellitus Typ I.