Effects of fish oil on serum lipids in men during a controlled feeding trial.
Effects of fish-oil (FO) feeding on serum lipids were investigated in a 42-d controlled diet study. Fifteen healthy male college students were assigned to one of three groups: control (0 g FO); 5 g FO, supplying 2 g n - 3 (omega-3) fatty acids (FAs); or 20 g FO, supplying 8 g n - 3 FAs. In an initial 7-d period subjects consumed a basal diet with no FO. Then FO replaced an equivalent amount of margarine for 5 wk. FO feeding significantly (p less than 0.05) decreased the serum n - 6 FAs, linoleic acid, eicosatrienoic acid, and arachidonic acid. A significant increase in the n - 3 FAs, eicosapentaenoic acid and docosahexaenoic acid, was noted in serum, platelet, and neutrophil phospholipids. The 20-g-FO group showed a 30% decrease (p less than 0.01) in triglycerides after 2 wk FO with no further decrease observed. Thus, 20 g FO produced changes in both FA patterns and triglyceride concentrations whereas 5 g FO produced changes in FA patterns only. Neither FO amount resulted in significant changes in total or HDL cholesterol, apolipoprotein A-I, or apolipoprotein B-100.
Department of Human Nutrition and Food Management, Ohio State University, Columbus 43210.
J P
JP
DeLany
V M
VM
Vivian
J T
JT
Snook
P A
PA
Anderson
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001792:Blood Platelets / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009504:Neutrophils / Q000032:analysis; D010743:Phospholipids / Q000097:blood; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D005227:Fatty Acids; D005395:Fish Oils; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol