Effects of antidepressants on human performance: a review.
Despite widespread use of antidepressants, major gaps remain in our knowledge of the effects of antidepressants on human performance. While most single-dose studies with normal subjects have suggested that the more sedating tricyclic antidepressants tend to produce impairment, the effects of antidepressant treatment in clinical populations have been less thoroughly examined, with both drug-induced impairment and improvement reported. This review suggests that factors such as age, diagnosis, drug plasma concentration, and length of treatment need to be explored to establish the effects of antidepressants on performance in clinical populations.
Deptula
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Geriatric Psychiatry Center, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York 10962.
Pomara
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D000367:Age Factors; D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D004316:Doxepin / Q000627:therapeutic use; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D011597:Psychomotor Performance / Q000187:drug effects*; D012016:Reference Values
D000928:Antidepressive Agents; D004316:Doxepin; D000639:Amitriptyline; D007099:Imipramine