Standard breakfast test: an alternative to glucagon testing for C-peptide reserve?
We measured C-peptide after glucagon and breakfast tests to compare the effectiveness of both tests in evaluating residual beta cell function in normal and diabetic subjects. A significantly higher C-peptide response was elicited after standard breakfast in patients with insulin-dependent diabetes mellitus of less than two years' evolution, ranging from 0.12 +/- 0.07 to 0.83 +/- 0.18 ng/ml (P less than 0.05). In nonobese noninsulin-dependent diabetes mellitus the response ranged from 0.86 +/- 0.02 to 1.89 +/- 0.48 ng/ml (P less than 0.0025); in obese NIDDM from 1.02 +/- 0.37 to 1.55 +/- 0.46 ng/ml (P less than 0.05), and in normal subjects from 0.77 +/- 0.23 to 2.11 +/- 1.22 ng/ml (P less than 0.0025). We conclude that the standard breakfast test is a useful and practical approach to the study of residual beta cell function.
Departamento de Medicina, Hospital Universitario de Granada, Spain.
F
F
Escobar-Jiménez
J L
JL
Herrera Pombo
R
R
Gómez-Villalba
J
J
Nuñez del Carril
M
M
Aguilar
A
A
Rovira
D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000378:metabolism*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005526:Food, Formulated; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged
D002096:C-Peptide; D005934:Glucagon