Histiocytoid (epithelioid) hemangioma of the testis. The so-called vascular variant of "adenomatoid tumor".
Adenomatoid tumors are well-recognized neoplasms generally considered to be of mesothelial derivation. We describe an unusual vascular neoplasm that arose in the testis of a 29-year-old and resembled an adenomatoid tumor by light microscopy. An orchiectomy was performed, and the patient is alive and disease-free 3 years later. The 2-cm tumor was composed of small tubules lined by mesothelial-like cells with uniform, vesicular nuclei. However, some lumina contained erythrocytes, and immunohistochemically, the luminal cells reacted with antibodies to vimentin, Factor VIII-related antigen, and Ulex europaeus I lectin but not cytokeratin or epithelial membrane antigen. A cuff of muscle-specific actin-positive cells surrounded the luminal cell layer. This adenomatoid-like vascular neoplasm is more properly interpreted as a histiocytoid (epithelioid) hemangioma. Although some authors have considered microscopically similar lesions to represent a vascular variant of adenomatoid tumor, we prefer to reserve the term "adenomatoid tumor" for microscopically appropriate proliferations that have mesothelial features.
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.
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Banks
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Mills
D000236:Adenoma / Q000098:blood supply* / Q000473:pathology; D000328:Adult; D006391:Hemangioma / Q000098:blood supply / Q000473:pathology*; D006392:Hemangioma, Cavernous / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D013736:Testicular Neoplasms / Q000098:blood supply / Q000473:pathology*; D013737:Testis / Q000473:pathology