[Diagnosis and treatment of celiac disease--what is the status in 1990?].
Summarizing the development of experiences and discussions of the last 20 years, a working group of the ESPGAN has recently updated the criteria of diagnosis of coeliac disease. The reliable finding of the initial typical mucosal lesion in the untreated patient is a hallmark of the disease and, if followed by an unequivocal clinical response to a gluten free diet, can be considered as final evidence for the diagnosis. Gluten challenges should be limited to cases without this evidence. High levels of antigliadin- and antireticulin- or or antiendomysium antibodies are supportive for the diagnosis but cannot substitute biopsy proof of the disease. The importance of a very long term strict gluten free diet in coeliac disease is established by recent evidence showing that in such cases there is no increased risk of malignancy.
Universitäts-Kinderklinik Zürich.
D H
DH
Shmerling
B
B
Winklhofer-Roob
D002446:Celiac Disease / Q000178:diet therapy / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*
D005983:Glutens
Diagnose und Behandlung der Zöliakie--Wo stehen wir 1990?