[A comparative study of atenolol (Tenormin) and the combined preparation atenolol/chlorthalidone (Tenoretic Mite) in essential hypertension. A randomized double-blind study from general practice].
Two hundred and ninety-two hypertensive patients from general practice who had previously been treated with a diuretic with insufficient effect participated in a randomised trial for a period of three months. A total of 115 patients completed treatment with 50 mg atenolol (Tanormin) and 121 were treated with the combined preparation consisting of 50 mg atenolol and 12.5 mg chlothalidone (Tenoretic Mite) while 56 patients defected from the trial. In both of the groups, the average blood pressure was reduced significantly already after treatment for one month. A significantly greater number of patients receiving combined treatment achieved satisfactory diastolic blood pressures (less than 90 mmHg), the proportions being 78% and 54%, respectively. Better effects from combined treatment were found particularly in patients over 60 years of age and in females. No significant differences were observed between the side-effects of the regimes nor in the laboratory values registered during treatment.
Centralsygehuset i Naestved, medicinsk afdeling.
S
S
Pilgaard
V O
VO
Palmelund
T L
TL
Svendsen
D000293:Adolescent; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use*; D002752:Chlorthalidone / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D004338:Drug Combinations; D001262:Atenolol; D002752:Chlorthalidone
En sammenlignende undersøgelse af atenolol (Tenormoin) og kombinationspraeparatet atenolol/klortalidon (Tenoretic Mite) ved essentiel hypertension. En randomiseret dobbeltblind undersøgelse fra almen praksis.