[Pulmonary blastoma. Immunohistochemical characterization of heteromorphic tumor components].
The reaction pattern found in thirteen different pulmonary blastomas was tested with four different polyclonal and six different monoclonal antibodies using the avidin-biotin-reaction. Immunohistochemically, the tumours showed positive reactions, both with antibodies that are considered to be epithelial markers (K11, EMA), and with antibodies that indicate a differening mesenchymal differentiation (vimentine, desmine, protein-S100). It was not possible to label any tumour cells with the antibodies anti-beta-HCG, anti-NSE, anti-lysozyme or anti-CEA. The negative response of the CEA reaction can be useful for the differentiation from pulmonary adenocarcinoma, in particular in the case of tumours with highly differentiated glandular components.
Institut für Pathologie der Berufsgenossenschaftlichen Krankenanstalten Bergmannsheil Bochum, Universitätsklinik Bochum.
M
M
Brockmann
A
A
Hecker
K M
KM
Müller
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor
Das pulmonale Blastom. Immunhistochemische Charakterisierung heteromorpher Tumorkomponenten.