Effect of yohimbine on plasma homovanillic acid in panic disorder patients and normal controls.
The effects of oral yohimbine (20 mg) or placebo or both drugs on plasma homovanillic acid (HVA) were evaluated in patients with panic disorder and normal controls. Panic disorder patients had similar HVA values at baseline compared with normal controls, and yohimbine failed to produce appreciable changes in HVA in both groups. These findings are discussed within the context of catecholaminergic theories of panic disorder.
Gurguis
G N
GN
Section on Anxiety and Affective Disorders, National Institute of Mental Health, Bethesda, MD 20892.
Uhde
T W
TW
D000328:Adult; D000379:Agoraphobia / Q000097:blood / Q000188:drug therapy*; D001143:Arousal / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D010200:Panic / Q000187:drug effects*; D015016:Yohimbine / Q000627:therapeutic use*
D015016:Yohimbine; D006719:Homovanillic Acid