Preimplantation genetic diagnosis: a new simple uterine washing system.
A new system for lavage of the uterine cavity and blastocyst recovery has been developed. The system was tested two or more times in 11 volunteer women at high genetic risk and waiting for its clinical application. Insertion into the uterine cavity was performed under continuous ultrasonic surveillance and was successfully achieved in all cases, 73% of whom reported some pains. A volume of 40 ml of warmed sterile saline solution was injected for washing of the uterine cavity and the total volume was always recovered without any sonographically visible leakage into the peritoneal cavity. No clinical infection or menstrual irregularities were observed and the only complications after the procedure were a short lasting spotting and light menstrual-like pains. The new system, owing to its efficacy, practicality and safety, is specifically indicated for preimplantation genetic diagnosis of blastocysts.
First Institute of Obstetrics and Gynaecology, University of Milan, Italy.
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D001755:Blastocyst; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D011296:Prenatal Diagnosis / Q000379:methods*; D007507:Therapeutic Irrigation; D014463:Ultrasonography; D014599:Uterus