Two additional cases of t dic(9:12) in acute lymphocytic leukemia (ALL): prognosis in ALL with dic(9:12).
We report two occurrences of dic(9;12) in acute lymphoblastic leukemia and review previous cases. Cases of dic(9;12) share common features with cases of 9p and 12p rearrangements, but prognosis seems particularly good in cases of dic(9;12). The persistence of a specific dicentric in stable clones is remarkable and points to unusual centromeric behavior and/or marked selective advantage of the anomaly.
Département d'Hématologie et Oncologie Médicale, CNRS URA 1338, Hôpital Jean Bernard, Poitiers, France.
J L
JL
Huret
N A
NA
Heerema
A
A
Brizard
A J
AJ
Provisor
E
E
Benz-Lemoine
F
F
Guilhot
J R
JR
Savage
J
J
Tanzer
D000328:Adult; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D014178:Translocation, Genetic