Bombesin: potential integrative peptide for feeding and satiety.
The neuropeptide bombesin (BBS) is examined with regard to possible designation as an integrative peptide. The term integrative peptide has been proposed to distinguish a subset of regulatory peptides. These peptides, distributed in the body and the brain, may function as hormones and neurotransmitters to integrate physiological and psychological functions. It is suggested that BBS may function as a peripheral and central satiety-inducing agent. The specific topics with regard to BBS include: feeding, satiety, and aversion; peripheral and central effects; learning, memory, and reward; route of injection; taste modulation; gastrointestinal activity; neurotransmitter status; mechanism and neuroanatomical site of action; and neural and humoral transmission.
Department of Psychology, Colorado State University, Ft. Collins 80523.
J G
JG
McCoy
D D
DD
Avery
D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D004064:Digestive System / Q000378:metabolism; D007276:Injections, Intraventricular; D009420:Nervous System / Q000187:drug effects; D009424:Nervous System Physiological Phenomena; D012527:Satiation / Q000187:drug effects / Q000502:physiology*; D013649:Taste / Q000187:drug effects
D001839:Bombesin