Invasive external otitis caused by Aspergillus.
Invasive external otitis occurs almost exclusively in patients with longstanding diabetes. Except for occasional cases, the etiologic agent has been Pseudomonas aeruginosa. We report a case caused by Aspergillus species in a diabetic patient with acute leukemia. Persistent infection was documented by culture and histology after a course of intravenous amphotericin B (total dose, 2 g). Clinical resolution occurred in association with a 3-month course of oral itraconazole. Four previously reported cases of invasive aspergillus otitis are reviewed.
Department of Medicine, Vancouver General Hospital, British Columbia, Canada.
P
P
Phillips
G
G
Bryce
J
J
Shepherd
D
D
Mintz
D001228:Aspergillosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008875:Middle Aged; D010032:Otitis Externa / Q000209:etiology*