Novel perspectives for structuring synthetic inhibitors of human blood platelet aggregation and potential antithrombotic agents.
An overview is presented on using molecular probes in tracing platelet function response patterns to specific structural features and physicochemical characteristics. Our carbamoylpiperidine nipecotoylpiperazine and related congeners are yielding new insights for as yet uncharted mechanisms of thrombocyte interaction dynamics, and the findings indicate promise for the development of novel potential antithrombotic agents.
Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee, Memphis 38163.
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Lasslo
D000818:Animals; D015195:Drug Design; D005343:Fibrinolytic Agents / Q000138:chemical synthesis*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors