Regulation, clinical and biological significance of cathepsin D in breast cancer.
The lysosomal protease, pro-cathepsin D, is overexpressed and secreted by human breast cancers. In estrogen-responsive breast cancer cell lines, estrogens and growth factors stimulate cathepsin D expression through distinct mechanisms. Clinical studies indicate that high cathepsin D concentration in primary breast cancers is correlated with an increased risk of metastasis and particularly useful to orientate node-negative tumors towards an adjuvant therapy.
Unité Hormones et Cancer (U 148) INSERM, Montpellier, France.
M
M
García
P
P
Augereau
P
P
Briozzo
F
F
Capony
V
V
Cavailles
G
G
Freiss
T
T
Maudelonde
P
P
Montcourrier
F
F
Vignon
H
H
Rochefort
D001943:Breast Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D002402:Cathepsin D / Q000096:biosynthesis / Q000502:physiology*; D004790:Enzyme Induction / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000502:physiology*; D009376:Neoplasms, Hormone-Dependent / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D014407:Tumor Cells, Cultured / Q000201:enzymology
D004967:Estrogens; D009363:Neoplasm Proteins; D002402:Cathepsin D