Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients.
The authors report two cases of ejaculatory dysfunction induced by fluoxetine. Cyproheptadine, an antihistaminic and antiserotonergic drug, restored sexual function in each case. Possible mechanisms of fluoxetine-induced anorgasmia are presented and treatment options are reviewed.
Erich Lindemann Mental Health Center, Boston, MA 02114.
S
S
McCormick
J
J
Olin
A W
AW
Brotman
D000328:Adult; D003533:Cyproheptadine / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy; D004542:Ejaculation / Q000187:drug effects; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009948:Orgasm / Q000187:drug effects*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000188:drug therapy
D005473:Fluoxetine; D003533:Cyproheptadine