[Steroid hormone receptor status of colorectal cancers].
Tumor samples of 26 consecutive colorectal carcinomas were studied for the presence of steroid hormone receptors for estrogen and progesterone. In all cases, the estradiol receptor binding capacity was below 2 fmol/mg cytosol protein. In 4 of 26 samples, progesterone receptor levels from 13 to 23 fmol/mg cytosol protein were observed. Because of the identification of steroid receptors in some cases and single reports in literature about tumor regression under hormone therapy of colorectal carcinoma, further investigations seem indicated to study the hormone sensitivity of colorectal carcinoma.
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität Mainz.
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Mentges
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Gutt
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von Bülow
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Pollow
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Grill
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Bätz
D000368:Aged; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012007:Rectum / Q000473:pathology
D002272:Carcinoembryonic Antigen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
Zum Steroidhormonrezeptorenstatus kolorektaler Karzinome.