Comparison of technetium 99m-phytate and technetium 99m-sulphur colloid in primary bone tumours.
Eleven patients with proven primary bone tumour (five Ewing sarcomas, six osteosarcomas) and two cases of metastatic bone involvement (primary other than bone) were investigated with 99mTc-phytate and 99mTc-sulphur colloid to compare the behaviour of the two radiopharmaceuticals at the tumour site. After intravenous administration of the respective radiopharmaceutical, imaging of the tumour site and its contralateral part was carried out at 15 min and 1 h intervals. The data were stored in our computer. Bone scanning was also carried out in all patients. 99mTc-phytate uptake was observed at the tumour site in ten cases. The 99mTc-sulphur colloid study revealed sparse or no significant uptake in eight cases. In two patients, with osteosarcoma 99mTc-sulphur colloid investigation showed uptake at the primary tumour site. However, the distribution pattern is different from that of 99mTc-phytate. No significant uptake of either 99mTc-phytate or 99mTc-sulphur colloid was observed in the two patients with metastatic skeletal disease. It may be concluded that the unusual accumulation of 99mTc-phytate at the tumour site is not due to any generalized reticuloendothelial phenomenon and that the radiopharmaceutical itself is responsible for this.
Department of Nuclear Medicine, Kidwai Memorial Institute of Oncology, Bangalore, India.
P N
PN
Rao
S N
SN
Murthy
S N
SN
Muddukrishna
S
S
Devaru
E R
ER
Radhakrishnan
M K
MK
Bhargava
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D012516:Osteosarcoma / Q000000981:diagnostic imaging*; D010833:Phytic Acid; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging*; D013671:Technetium Tc 99m Sulfur Colloid
D015609:Organotechnetium Compounds; C026177:technetium phytate; D013671:Technetium Tc 99m Sulfur Colloid; D010833:Phytic Acid