Interaction between nonsteroidal anti-inflammatory drugs and high-dose methotrexate: a literature review.
An important step in preventing methotrexate (MTX) toxicity is to assess patient self-medication of over-the-counter drugs before high-dose methotrexate (HD-MTX) treatment is administered. Nonsteroidal anti-inflammatory drugs given within a 10-day period before a patient receives HDMTX leads to a decreased MTX excretion rate causing MTX toxicity. Education of the nursing staff and patients and their families is vital to avoid the potentially dangerous effects of a delayed MTX excretion rate.
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004347:Drug Interactions; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000451:nursing*; D009730:Nursing Assessment; D012651:Self Medication
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008727:Methotrexate