Inhibition of IgE synthesis by anti-IgE: role in long-term inhibition of IgE synthesis by neonatally administered soluble IgE.
Inoculation of syngeneic IgE into 2- to 12-day-old mice results in prolonged synthesis of anti-IgE antibodies without further challenge. These anti-IgE antibodies may be largely responsible for the long-term inhibition of synthesis of IgE that is known to result from a perinatal challenge with IgE. This conclusion is supported by the effect of passive inoculation of syngeneic polyclonal anti-IgE antibodies into young mice, which similarly results in selective inhibition of IgE synthesis. Further evidence is the close relationship between the age dependency of IgE-induced inhibition of subsequent IgE synthesis and the ability of IgE to induce anti-IgE antibodies. IgE synthesis was monitored at the level of secretion by B cells as well as serum IgE levels and IgE antibody responses.
Haba
S
S
Rosenstiel Research Center, Department of Biology, Brandeis University, Waltham, MA 02254.
Nisonoff
A
A
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001323:Autoantibodies / Q000276:immunology*; D003433:Crosses, Genetic; D005260:Female; D007116:Immunization, Passive; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000008:administration & dosage / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012016:Reference Values
D001323:Autoantibodies; D007073:Immunoglobulin E