Possible mechanism of antidepressant effect of L-sulpiride.
L-Sulpiride is a dopamine (DA)-receptor blocker that acts as an antidepressant at low doses. We have reviewed evidence suggesting that the antidepressant effect of L-sulpiride may depend on the activation of DA transmission secondary to the blockade of DA autoreceptors.
Serra
G
G
B. B. Brodie Department of Neurosciences, University of Cagliari, Italy.
Forgione
A
A
D'Aquila
P S
PS
Collu
M
M
Fratta
W
W
Gessa
G L
GL
D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D011954:Receptors, Dopamine / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013469:Sulpiride