Brain tumor as a second malignant neoplasm following neuroblastoma stage IV S.
A rare brain tumor (spongioblastoma polare) occurring 7 years after treatment of neuroblastoma stage IV S is reported. The literature concerning the occurrence of a second cancer in children exposed to mutagenic therapy for their initial tumor is reviewed, and genetic and environmental factors are discussed. Diminishing aggressiveness of the treatment in childhood cancer with good prognosis should be considered. Continuous follow-up of children cured of cancer is warranted.
Department of Pediatric Oncology, Rambam Medical Center, Technion School of Medicine, Haifa, Israel.
M W
MW
Ben-Arush
Y
Y
Doron
J
J
Braun
E
E
Mendelsson
H
H
Dar
E
E
Robinson
D000008:Abdominal Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D001254:Astrocytoma / Q000209:etiology*; D001932:Brain Neoplasms / Q000209:etiology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary; D009447:Neuroblastoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D012008:Recurrence