Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.
Serum concentrations of soluble interleukin-2 receptor (sIL-2R) were measured as a marker of immune activation in a group of 30 patients with Crohn's disease. sIL-2R concentrations were determined by enzyme linked immunosorbent assay during periods of active and inactive disease and correlated with standard parameters of disease activity. Serum concentrations of sIL-2R were significantly raised in patients with active Crohn's disease compared with patients with inactive disease (p less than 0.001) and control subjects. There was a significant correlation between serum sIL-2R concentrations and disease activity as assessed by the Harvey-Bradshaw index (r = 0.42, p less than 0.01), platelet numbers (r = 0.49, p less than 0.01), and orosomucoid (r = 0.47, p less than 0.01), alpha 1 antitrypsin (r = 0.44, p less than 0.01), and C reactive protein concentrations (r = 0.48, p less than 0.001) but not with the erythrocyte sedimentation rate. Measurement of serum sIL-2R concentration is a simple and useful laboratory means of assessing disease activity. Raised concentrations in patients with active Crohn's disease is further evidence for in vivo immune activation occurring in this disease.
Crabtree
J E
JE
Department of Medicine, St James's University Hospital, Leeds.
Juby
L D
LD
Heatley
R V
RV
Lobo
A J
AJ
Bullimore
D W
DW
Axon
A T
AT
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D003424:Crohn Disease / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012720:Severity of Illness Index; D000515:alpha 1-Antitrypsin / Q000032:analysis
D015375:Receptors, Interleukin-2; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein