Heterogeneity of DNA repair: implications for human disease and oncology.
DNA repair studies used to be confined to measurements representing an average over the entire mammalian genome. It is now possible to study repair processes at subgenomic levels including specific genes. We will describe such results and discuss the impact they may have on our understanding of important oncological processes. Also, we will describe and discuss some clinical conditions that may have some effect in DNA damage processing.
National Cancer Institute, Laboratory of Molecular Pharmacology, Division of Cancer Treatment, NIH, Bethesda, Maryland 20892.
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D004247:DNA / Q000235:genetics; D004249:DNA Damage; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans
D004273:DNA, Neoplasm; D004247:DNA