Ultrastructural, immunohistochemical, and cytogenetic study of a malignant peripheral neuroectodermal tumor in a patient seropositive for human immunodeficiency virus.
A case of malignant peripheral neuroectodermal tumor occurring during the course of a human immunodeficiency virus (HIV) infection is reported. The patient was a male homosexual who presented with a rapidly enlarging tumor of the posterior lower thoracic wall. By light microscopic examination the tumor was a small cell tumor showing occasional structures suggestive of Homer-Wright rosettes. The strong positivity for neuron-specific enolase and the neurosecretory granules indicated the neural differentiation of the tumor. Its precise nature was shown cytogenetically by the presence of the t(11;22) translocation, which distinguished it from the classical neuroblastoma.
Gariepy
G
G
Department de Pathologie, Hopital Saint-Luc, Montreal, (Quebec), Canada.
Drouin
R
R
Lemieux
N
N
Richer
C L
CL
D000328:Adult; D002871:Chromosome Banding; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D008297:Male; D008854:Microscopy, Electron; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure*; D013909:Thorax