A double-blind, placebo-controlled trial of fluoxetine plus behavior modification in the treatment of obese binge-eaters and non-binge-eaters.
To determine whether fluoxetine is effective in the long-term treatment of obesity and whether it is particularly useful in the treatment of obese binge-eaters, the authors randomly assigned 45 obese subjects (22 with binge-eating problems and 23 without binge-eating) to fluoxetine (60 mg/day) or placebo in a 52-week double-blind trial. The 21 subjects who completed the trial made 13 clinic visits and were taught basic behavior modification strategies. Patients treated with fluoxetine plus behavior modification lost significantly more weight than those treated with placebo plus behavior modification. However, the drug did not appear to have a differential benefit for binge-eaters.
Department of Psychiatry, University of Pittsburgh School of Medicine, PA.
M D
MD
Marcus
R R
RR
Wing
L
L
Ewing
E
E
Kern
M
M
McDermott
W
W
Gooding
D000293:Adolescent; D000328:Adult; D001294:Attitude to Health; D001521:Behavior Therapy; D002032:Bulimia / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D010349:Patient Compliance; D010555:Personality Inventory; D010919:Placebos; D015431:Weight Loss
D010919:Placebos; D005473:Fluoxetine