In vitro effects of retinoic acid.
Retinoids, synthetic and natural analogues of vitamin A, play fundamental roles both in directing the spatial organization of cells during the development of vertebrate limbs and in the maintenance of growth and differentiation of many adult tissues. They also block the phenotypic expression of cancer in vitro; inhibit growth and induce differentiation in many animal and human malignant cell types. They have proved beneficial in skin diseases, cancer prevention and in acute promyelocytic leukemia.
Chomienne
C
C
Médecine Nucléaire, Hôpital Saint-Louis, Paris, France.
Ballerini
P
P
Huang
M
M
Cornic
M
M
Abita
J P
JP
Castaigne
S
S
Degos
L
L
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology; D013723:Teratogens; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D013723:Teratogens; D014212:Tretinoin