Pulmonary-renal syndrome with "triad" involvement due to small vessel vasculitis.
We describe the clinical course and morphologic findings of a 22-year-old woman presenting with a systemic disease that included nasal ulceration, hemoptysis and rapidly progressive renal failure. Biopsies of nasal septum and lung revealed small vessel leukocytoclastic angiitis while renal biopsy showed a diffuse crescentic glomerulonephritis. Immunosuppressive therapy resulted in remission of clinical symptoms and resolution of glomerulonephritis as documented in a followup biopsy. Although her clinical presentation with triad organ involvement strongly suggested Wegener's granulomatosis, this case illustrates that other varieties of vasculitis may mimic Wegener's granulomatosis.
Doebbeling
B N
BN
Department of Medicine, University of Iowa College of Medicine, Iowa City 52242.
Bonsib
S M
SM
Walker
W P
WP
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D014890:Granulomatosis with Polyangiitis / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000473:pathology*; D013577:Syndrome; D014657:Vasculitis / Q000473:pathology*