[Isoptin Retard. Pharmacokinetics and pharmacodynamics in patients with angina pectoris].
Sustained-release Verapamil is suitable for treatment of angina pectoris. The initial dose should be 240 mg administered at bedtime. If the desired effect is not obtained, the dosage may be increased first to 360 mg at bedtime and then to 240 mg morning and evening. In patients already receiving treatment with standard Verapamil, this may be replaced by Sustained-release Verapamil mg for mg. In long-term treatment the half life is increased and reduction of the dosage should, therefore, be attempted.
Bispebjerg Hospital, København, medicinsk afdeling P.
C M
CM
Jespersen
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D006801:Humans; D014700:Verapamil / Q000097:blood / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D014700:Verapamil
Isoptin retard. Farmakokinetik og -dynamik hos patienter med angina pectoris.