Direct-acting mutagenic properties of some hair dyes used in New Zealand.
Mutagenicity or carcinogenicity data are not publicly available on many hair dyes or dye components commonly used within New Zealand. Representative mid- to dark-warm brown hair dyes of 12 brands supplying more than 1% of the New Zealand market were tested for direct-acting mutagenicity using the bacterial 'Ames' test. Despite recent scientific advances in the development of non-mutagenic dyes, 23 of the 40 products tested gave positive results in one or both of the tester strains used. There appeared to be differences between distributors in the proportion of their hair dyes which were mutagenic. In the case of 6 out of 10 of the above dyes which had tested positive, in vitro mutagenicity or toxicity was enhanced in the presence of verapamil, suggesting that risks from hair-dye exposure may change in the case of persons using this or similar drugs. It is recognised that there are uncertainties regarding human risks from dyes which are shown to be mutagenic in in vitro tests. However, from the above results, it seems possible to produce non-mutagenic hair dyes in this color range; and in the interests of public reassurance, it may be prudent to require that such dyes be used.
Cancer Research Laboratory, University of Auckland Medical School, New Zealand.
L R
LR
Ferguson
A M
AM
Roberton
J
J
Berriman
D004357:Drug Synergism; D006202:Hair Dyes / Q000633:toxicity*; D006203:Hair Preparations / Q000633:toxicity*; D009152:Mutagenicity Tests; D009520:New Zealand; D012486:Salmonella typhimurium / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D006202:Hair Dyes; D006203:Hair Preparations; D014700:Verapamil