The role of the blood-brain barrier in movement disorders.
The entry of drugs and other biological compounds into the brain is a process that can be considered separately from the effects of those drugs and compounds once they have entered the brain. The rate of entry of compounds into the brain may occur either by passive diffusion or by carrier-mediated transport. Many processes interact to affect the amount of the compound that eventually enters the brain, including protein binding, systemic metabolism, and local metabolism and diffusion within the brain.
Paleologos
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Department of Neurology, Northwestern University Medical School, Evanston Hospital, Illinois.
Groothuis
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DR
D001692:Biological Transport; D001812:Blood-Brain Barrier; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery