Correlation between gallium-67 imaging and endomyocardial biopsy in children with severe dilated cardiomyopathy.
Fourty-four patients (aged 10 months to 15 years) were assessed in a double-blind study to observe the correlation between myocardial uptake of 67-gallium and endomyocardial biopsy in the detection of moderate to severe myocardial inflammation. The sensitivity and specificity of gallium-67 imaging were 87 and 81%, respectively. Based on these findings, immunosuppressive therapy can be assigned to children with dilated cardiomyopathy and positive myocardial uptake, since moderate and severe myocardial inflammation may be detected by this non-invasive method.
Camargo
P R
PR
Heart Institute, University of São Paulo Medical School, Brazil.
Mazzieri
R
R
Snitcowsky
R
R
Higuchi
M L
ML
Meneghetti
J C
JC
Soares Júnior
J
J
Fiorelli
A
A
Ebaid
M
M
Pileggi
F
F
D000293:Adolescent; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005710:Gallium Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D009206:Myocardium / Q000473:pathology; D011877:Radionuclide Imaging; D015203:Reproducibility of Results
D005710:Gallium Radioisotopes