Molecular aspects of some virulence factors of Haemophilus somnus.
Several virulence factors of Haemophilus somnus have been investigated, but to a varying extent. It is known that some isolates are more virulent than others. Factors associated with virulence include attachment to vaginal epithelial cells, turbinate cells or embryos; serum resistance; growth stimulation by normal flora; interference with phagocyte function; Fc receptors; and toxicity for several bovine cell types. Lipooligosaccharide and Fc receptors have been investigated at the molecular level and studies are in progress to relate their molecular structure to virulence.
Corbeil
L B
LB
Department of Pathology, UCSD Medical Center 92103.
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D006190:Haemophilus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006192:Haemophilus Infections / Q000382:microbiology / Q000662:veterinary*; D008070:Lipopolysaccharides / Q000235:genetics; D011961:Receptors, Fc / Q000235:genetics; D014774:Virulence
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D011961:Receptors, Fc; C023023:lipid-linked oligosaccharides