Age-related changes in uptake and release on L-[3H]noradrenaline in brain slices of senescence accelerated mouse.
High K+ and N-methyl-D-aspartate (NMDA) evoked L-[3H]noradrenaline (NA) release to a similar degree in the brain slices of 1-month-old senescence-accelerated resistant mice (SAM-R/1) and senescence-accelerated prone mice (SAM-P/8). However, 30 mM KCl-induced L-[3H]NA release significantly diminished in SAM-P/8 from 3 to 12 months without changing in SAM-R/1. In addition, NMDA-induced L-[3H]NA release was also reduced at 3 months and lowered to a level of spontaneous release at 12 months in SAM-P/8, but no age-related changes in SAM-R/1 were observed. It is suggested that NA release from NA nerve terminals responsive to depolarization is reduced in SAM-P/8 at an earlier stage than in SAM-R/1. Furthermore, NMDA receptors which could be localized in the soma and/or nerve terminals, seem to be involved in NA release and to be decreased with advancing age in SAM-P/8.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
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Zhao
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Nomura
D000375:Aging; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001692:Biological Transport; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016202:N-Methylaspartate; D009638:Norepinephrine / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology
D001224:Aspartic Acid; D016202:N-Methylaspartate; D011189:Potassium Chloride; D009638:Norepinephrine