[Contribution of murine models of spontaneous lupus to the analysis of genetic factors in human disease].
Genetic factors contribute to the expression of human systemic lupus erythematosus (SLE): they appear to be complex and are difficult to study in man. Most advances have been made as a result of studies of spontaneous murine models of SLE, either by conventional genetics or molecular biology. The former demonstrated that no single or simple genetic explanation of the disease is likely and that the immune manifestations are multigenic. Molecular biology techniques suggest that disease-associated genes probably lie within the major histocompatibility complex (MHC) of NZW mice and seem to be genes coding for MHC class II antigens. Such an analysis of genes encoding elements involved in immune system functions (e.g., immunoglobulins, T cell antigen and MHC antigen receptors) provides valuable information concerning the role(s) of genetic factors leading to SLE.
Laboratoire d'Immunologie, CHRU Charles-Nicolle, Rouen.
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D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D001323:Autoantibodies / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains
D000945:Antigens, Differentiation, T-Lymphocyte; D001323:Autoantibodies
Apport des modèles murins spontanés de lupus à l'analyse des facteurs génétiques de la maladie humaine.