Evidence for a hyperglycaemia-dependent decrease of antithrombin III-thrombin complex formation in humans.
In the presence of increased levels of fibrinopeptide A, decreased antithrombin III biological activity, and thrombin-antithrombin III complex levels are seen in diabetic patients. Induced-hyperglycaemia in diabetic and normal subjects decreased antithrombin III activity and thrombin-antithrombin III levels, and increased fibrinopeptide A plasma levels, while antithrombin III concentration did not change; heparin was shown to reduced these phenomena. In diabetic patients, euglycaemia induced by insulin infusion restored antithrombin III activity, thrombin-antithrombin III complex and fibrinopeptide A concentrations; heparin administration had the same effects. These data stress the role of a hyperglycaemia-dependent decrease of antithrombin III activity in precipitating thrombin hyperactivity in diabetes mellitus.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italy.
Giugliano
D
D
Quatraro
A
A
Marchi
E
E
Barbanti
M
M
Lefèbvre
P
P
D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis; D006493:Heparin; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D007700:Kinetics; D008297:Male; D010447:Peptide Hydrolases / Q000032:analysis*; D012016:Reference Values
D001786:Blood Glucose; C046193:antithrombin III-protease complex; D005344:Fibrinopeptide A; D000990:Antithrombin III; D006493:Heparin; D010447:Peptide Hydrolases