Autoantibodies to the insulin receptor are infrequent findings in type 1 (insulin-dependent) diabetes mellitus of recent onset.
To determine whether autoantibodies to the insulin receptor may represent markers of Type 1 (insulin-dependent) diabetes, the prevalence of such antibodies was investigated in sera of 60 newly diagnosed untreated Type 1 diabetic patients. A sensitive assay, based on enzyme linked immunosorbent assay has been set up which detects antibodies to the insulin receptor irrespective of their potentially inhibiting effect on insulin binding. Moreover, this method allows easy determination of the immunoglobulin class involved in the anti-receptor activity. Among the 60 sera examined, only one was found to contain anti-insulin receptor autoantibodies (IgG class). In view of our data, we conclude that autoantibodies to the insulin receptor are infrequent findings in Type 1 diabetes of recent onset.
INSERM U 145, Faculté de Médecine, Nice, France.
N
N
Rochet
J L
JL
Sadoul
B
B
Ferrua
J
J
Kubar
J F
JF
Tanti
P
P
Bougnères
B
B
Vialettes
E
E
Van Obberghen
Y
Y
Le Marchand-Brustel
P
P
Freychet
D000293:Adolescent; D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology*; D004622:Embryo, Mammalian; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis*; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D051381:Rats; D011972:Receptor, Insulin / Q000235:genetics / Q000276:immunology*; D012016:Reference Values; D014162:Transfection
D001323:Autoantibodies; D007330:Insulin Antibodies; C024211:islet cell antibody; D011972:Receptor, Insulin