Hepatic peroxisomal and microsomal enzyme induction by citral and linalool in rats.
The short-term effects of oral administration of citral and linalool to rats have been compared. Male Wistar rats were given, by gastric intubation, 1.5 g citral or linalool/kg body weight/day for 5 days. Citral caused peroxisome proliferation as indicated by induction of cyanide-insensitive palmitoyl-CoA oxidation and bifunctional enzyme; levels of microsomal cytochrome P-450 IVA1 were also raised. Linalool caused induction of the peroxisomal enzymes but not of cytochrome P-450 IVA1, indicating that it possesses activity somewhat different from that of citral. These results suggest that the mechanisms of peroxisome proliferation may be independent of induction of cytochrome P-450 IVA1.
University of Surrey, Department of Biochemistry, Guildford, UK.
S J
SJ
Roffey
R
R
Walker
G G
GG
Gibson
D000080462:Acyclic Monoterpenes; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008958:Models, Molecular; D039821:Monoterpenes; D009097:Multienzyme Complexes / Q000096:biosynthesis*; D010171:Palmitoyl Coenzyme A / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000378:metabolism / Q000494:pharmacology*
D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D009097:Multienzyme Complexes; D013729:Terpenes; D010171:Palmitoyl Coenzyme A; D003577:Cytochrome P-450 Enzyme System; C018584:linalool; C007076:citral