[Hypovolemic-hemorrhagic shock. Pathophysiology and therapy].
The common features of all different kinds of circulatory shock are a disturbance of the microcirculation and an imbalance between cellular oxygen demand and supply. The pathophysiology is discussed by the example of hypovolemic-hemorrhagic shock, including macrocirculation, humoral regulatory mechanisms, the role of vascular endothelium, and cellular dysfunction. The first aim of therapeutic efforts is the rapid restitution of a normal circulatory volume as a basic requirement for the normalisation of the microcirculation. Actual concepts of volume substitution and transfusion therapy are presented.
Institut für Anästhesiologie der Ludwig-Maximilians-Universität, München.
J
J
Groh
H J
HJ
Dieterich
K
K
Peter
D001803:Blood Transfusion / Q000379:methods*; D001810:Blood Volume / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005440:Fluid Therapy / Q000379:methods*; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D012769:Shock / Q000503:physiopathology / Q000628:therapy*
Hypovolämisch-hämorrhagischer Schock. Pathophysiologie und Therapie.