Advantages of mouse models to study early steps of peripheral nervous system development.
The molecular mechanisms involved in the formation of mammalian peripheral nervous system remain largely unknown. Here we describe the new possibilities offered by mouse mutant analysis, new mouse in vitro models and the recent development of molecular genetic techniques which may permit analysis of the peripheral nervous system development at a level that was heretofore restricted to lower vertebrates.
Boisseau
S
S
Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, Gif-sur-Yvette Cedex.
Semonin
O
O
Leconte
L
L
Larmet
Y
Y
Poujeol
C
C
Simonneau
M
M
D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D008967:Molecular Biology; D009432:Neural Crest / Q000166:cytology / Q000196:embryology*; D010525:Peripheral Nerves / Q000196:embryology*