Stimulation of p21ras upon T-cell activation.
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
Signal Transduction Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
J
J
Downward
J D
JD
Graves
P H
PH
Warne
S
S
Rayter
D A
DA
Cantrell
D020690:GTPase-Activating Proteins; D011905:Genes, ras; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008213:Lymphocyte Activation; D015689:Oncogene Protein p21(ras) / Q000235:genetics* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; D020703:ras GTPase-Activating Proteins; D011493:Protein Kinase C; D015689:Oncogene Protein p21(ras)