Randomised double blind placebo controlled clinical trial of sucralfate and ranitidine in chronic duodenal ulcer.
A double blind, randomised, placebo controlled clinical trial was carried out in endoscopically proved chronic duodenal ulcer patients to compare the efficacy of sucralfate and ranitidine. Sucralfate 1 g four times daily and ranitidine 150 mg twice daily were found to be equally effective in inducing ulcer healing (73.1% and 82.1% respectively) during the 6-week treatment period. The rate of recurrence of the ulcer within six months after the initial treatment (84.2% and 82.6%) was also comparable in the sucralfate and ranitidine groups. Sucralfate and ranitidine are equally effective in ulcer healing and prevention of ulcer relapse.
Department of Gastroenterology, Medical College, Calicut, Kerala.
K V
KV
Nair
T M
TM
Ramachandran
V
V
Thomas
T
T
Rajindranath
D000328:Adult; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000627:therapeutic use*; D012008:Recurrence; D013392:Sucralfate / Q000627:therapeutic use*
D013392:Sucralfate; D011899:Ranitidine