Mechanisms of toxic cell injury.
The biochemical mechanisms by which xenobiotic agents initiate cell injury involve networks of interactions at a variety of molecular and structural targets. The author highlights current concepts in six major areas of investigation: covalent binding, oxidative stress, alterations of glutathione and protein thiols, peroxidation and hydrolysis of phospholipids, mitochondrial deenergization, and alterations of intracellular calcium homeostasis.
Snyder
J W
JW
Division of Environmental Medicine and Toxicology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
D002118:Calcium / Q000378:metabolism; D002477:Cells / Q000187:drug effects*; D004734:Energy Metabolism; D005978:Glutathione / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D008565:Membrane Proteins; D010743:Phospholipids; D005978:Glutathione; D010100:Oxygen; D002118:Calcium