Uncoupling of cerebral blood flow and glucose metabolism in conscious rats with chronic renal hypertension.
In an analysis of 46 individual brain structures and regions, we found that 12-14 weeks of renal hypertension in rats were associated with a 42% increase in cerebrovascular resistance, an average 28% reduction in cerebral blood flow, and no general change in cerebral glucose metabolism. A specific increase in metabolic activity, however, was identified in locus coeruleus. Generalized cerebral vasoconstriction resulting from central noradrenergic innervation originating in locus coeruleus is a possible explanation for the uncoupling of cerebral blood flow and metabolism in rats with chronic renal hypertension.
Wall
K M
KM
Department of Surgery, Queen's University Hospital, Kingston, Ont., Canada.
Wainman
D S
DS
Shaver
S W
SW
Gross
P M
PM
D000818:Animals; D001783:Blood Flow Velocity; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005947:Glucose / Q000378:metabolism*; D006977:Hypertension, Renal / Q000378:metabolism / Q000503:physiopathology*; D008125:Locus Coeruleus / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014655:Vascular Resistance
D005947:Glucose