Physiology of the peritoneum. Implications for peritoneal dialysis.
Solute and water transport from blood to peritoneal cavity occur by diffusion and osmotic ultrafiltration, whereas absorption to blood via lymphatics negatively affects these two processes. This article delineates the physiology of peritoneal membrane and numerous factors that influence mass transport during peritoneal dialysis, thereby affecting its therapeutic efficacy. Benefits and limitations of continuous ambulatory peritoneal dialysis (CAPD) are discussed and compared to those of hemodialysis. Survival on CAPD, its complications and imperfections are reviewed in light of the widespread acceptance of the procedure.
Nephrology Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
J F
JF
Maher
D000042:Absorption; D001810:Blood Volume; D015314:Dialysis Solutions / Q000493:pharmacokinetics; D005069:Evaluation Studies as Topic; D006801:Humans; D007700:Kinetics; D008566:Membranes / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000401:mortality; D010537:Peritoneum / Q000033:anatomy & histology / Q000502:physiology*; D010539:Permeability; D011453:Prostaglandins / Q000627:therapeutic use; D006435:Renal Dialysis; D013152:Splanchnic Circulation; D013534:Survival; D014462:Ultrafiltration; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use
D015314:Dialysis Solutions; D011453:Prostaglandins; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents