Protein turnover is elevated in muscle of mdx mice in vivo.
mdx mice lack the protein dystrophin, the absence of which causes Duchenne muscular dystrophy in humans. To examine how mdx mice maintain muscle mass despite dystrophin deficiency, we measured protein turnover rates in muscles of mdx and wild-type (C57BL/10) mice in vivo. At all ages studied, rates of muscle protein synthesis and degradation were higher in mdx than in C57BL/10 mice.
MacLennan
P A
PA
Department of Medicine, University of Liverpool, U.K.
Edwards
R H
RH
D000375:Aging / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D016189:Dystrophin; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009124:Muscle Proteins / Q000172:deficiency / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000378:metabolism
D016189:Dystrophin; D009124:Muscle Proteins