[Interaction of bactericidal serum effect and antibiotics in subminimal inhibitory concentrations on E. coli strains].
Imipenem (IMI) forming round cells in Gram negative rods reduces in subinhibitory concentrations (subMIC) the seroresistance of E. coli. This effect is distinctly more pronounced in a moderately seroresistant strain of E. coli than in a high seroresistant one. Conversely, human serum (HS) increases the sensitivity of E. coli strains to IMI dependent on their original seroresistance. In contrast, ampicillin (AMP), a filament inducer in E. coli, reduces equally seroresistance but only to a minimal degree and that only in a moderately seroresistant strain; the high seroresistant strain was nonreactive in this respect. It was concluded, that a synergism of antibiotics and bactericidal serum effect is predominantly produced with round cell forming antibiotics, whereas filament forming ones show only minimal effects. Moreover, the original seroresistance of strains in apparently important for the degree tho which these phenomena are expressed.
Institut de Microbiologie Médicale, Faculté de Médecine, Université d'Aix-la-Chapelle.
G
G
Gillissen
M
M
Schumacher
M
M
Breuer-Werle
D000667:Ampicillin / Q000494:pharmacology*; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects*; D015378:Imipenem / Q000494:pharmacology*; D066298:In Vitro Techniques; D015610:Serum Bactericidal Test
D015378:Imipenem; D000667:Ampicillin
Interaction entre l'effet bactéricide du sérum et des antibiotiques à concentrations sous-inhibitrices sur les souches d'E. coli.