Conformationally restricted peptides through short-range cyclizations.
The various types of conformationally restricted peptides obtained by short-range cyclizations, from residue i to residue i + 1, are presented. Relevant examples of N in equilibrium C alpha, C' in equilibrium C alpha, N in equilibrium C', C alpha in equilibrium C alpha, C' in equilibrium C', and N in equilibrium N cyclizations are reported and the pertinent literature listed. In the discussion emphasis is place on the conformational consequences for peptides from the incorporation of such ring structures.
Toniolo
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C.N.R., Department of Organic Chemistry, University of Padova, Italy.
D003500:Cyclization; D010456:Peptides, Cyclic / Q000032:analysis / Q000138:chemical synthesis*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D010456:Peptides, Cyclic