[The effect of luliberin and sulpiride on the secretion of gonadotropic hormones and prolactin in patients with obesity].
The role of dopamine (DA) in the secretion of gonadotropic hormones was studied in women with obesity and normal body mass. Tests with sulpiride (peripheral antagonist of DA-receptors), sulpiride LH-RH and thyroliberin were made. Basal and LH-RH-stimulated secretion of gonadotropins and prolactin (PRL) was studied to reveal the relationship of their secretion with the status of the hypothalamohypophyseal system. It was shown that the blockade of peripheral DA receptors did not result in an increase in the basal and LH-RH-stimulated secretion of LH either in healthy women or in women with obesity at the normal basal level of gonadotropic hormones. Hyperprolactinemia caused by sulpiride or LH-RH, did not lower LH secretion during the entire period of investigation. There were no differences either in the basal level of gonadotropic hormones or in their ejection in response to LH-RH administration in women with normal and excess body mass. Stimulation of PRL secretion in response to LH-RH was found in patients with exogenous-constitutional obesity and minimum signs of diencephalic pathology. Slight inhibition of PRL secretion after LH-RH administration was noted in women with obesity of hypothalamic type and unstable type of disorder of EEG. The absence of changes in PRL secretion was noted in women with strongly marked hypothalamic signs of the disease.
Dobracheva
A D
AD
Butrova
S A
SA
D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000097:blood*; D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D013469:Sulpiride; D013997:Time Factors
D006065:Gonadotropins, Pituitary; D010906:Pituitary Hormone-Releasing Hormones; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D013469:Sulpiride; D011388:Prolactin
Vliianie liuliberina i sul'pirina na sekretsiiu gonadotropnykh gormonov i prolaktina u bol'nykh ozhireniem.