Hypoaminoacidemia caused by imipramine but not by clenbuterol is dissociable from hyperglycemia and hyperinsulinemia.
The effects of the tricyclic antidepressant imipramine (20 mg/kg) and the beta-adrenoceptor agonist clenbuterol (0.5 mg/kg) on the serum concentrations of tyrosine, tryptophan, glucose and insulin were compared 30 min after intraperitoneal injection. The drugs had nearly identical effects on serum tyrosine, which was reduced to 73% of control by both drugs, and on tryptophan, which was reduced to 72% by imipramine and to 66% by clenbuterol. In contrast, whereas clenbuterol raised serum glucose to 174% and insulin to 379% of control, imipramine had no significant effects on either glucose or insulin. The results clearly demonstrate that the effects of imipramine on blood amino acid levels are dissociable from effects on glucose and insulin. We conclude, therefore, that hypoaminoacidemia caused by imipramine is not mediated by stimulating insulin release.
Department of Pharmacology-Physiology, School of Dental Medicine, University of Pittsburgh, PA 15261.
D J
DJ
Edwards
M A
MA
Virji
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000097:blood*; D014443:Tyrosine / Q000097:blood*
D001786:Blood Glucose; D004983:Ethanolamines; D007328:Insulin; D014443:Tyrosine; D014364:Tryptophan; D007099:Imipramine; D002976:Clenbuterol