Effect of delapril hydrochloride on angiotensin II release from isolated rat hind legs.
The effect of the newly developed angiotensin-converting enzyme (ACE) inhibitor, delapril hydrochrolide (CV-3317), on the release of immunoreactive angiotensin II (irAng II) from isolated rat hind legs was compared with that of captopril. Both ACE inhibitors, added to the perfusion medium (2 X 10(-9) - 10(-6) M), suppressed irAng II release in a dose-dependent manner, but the inhibition was greater with delapril than with captopril. The results provide further support for the concept that vascular tissues produce Ang II and release it in a regulated fashion. The results also suggest a possible link between the antihypertensive mechanism of ACE inhibitors, including delapril, and the suppression of vascular Ang II release.
Third Department of Internal Medicine, Fukushima Medical College, Japan.
K
K
Mizuno
S
S
Niimura
M
M
Tani
S
S
Fukuchi
T
T
Inagami
D000804:Angiotensin II / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D006614:Hindlimb / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000806:Angiotensin-Converting Enzyme Inhibitors; D007189:Indans; D000804:Angiotensin II; D002216:Captopril; C047759:delapril