Low molecular weight heparin restores antithrombin III activity from hyperglycemia induced alterations.
Alteration of antithrombin III (ATIII) activity, glycemia level dependent, exists in diabetes mellitus. In this study the ability of a low molecular weight heparin (LMWH) (Fluxum, Alfa-Wassermann S.p.A., Bologna, Italy), as well as unfractioned héparin, to preserve ATIII activity from glucose-induced alterations, both in vitro and in vivo, is reported. The subcutaneous and intravenous LMWH and heparin administration increases basal depressed ATIII activity in diabetic patients. Heparin shows an equivalent effect on both anti-IIa and anti-Xa activity of ATIII, while LMWH is more effective in preserving the anti-Xa activity. Similarity, heparin preserves ATIII activity from hyperglycemia-induced alterations, during hyperglycemic clamp, and LMWH infusion is able to preserve a significant amount of anti-Xa activity from glucose-induced alterations. Since diabetic patients show a high incidence of thrombotic accidents, LMWH appears to be a promising innovation for the prevention of diabetic thrombophylia.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Universita di Napoli, Italy.
Marchi
E
E
Palazzni
E
E
Quatraro
A
A
Giugliano
D
D
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D000991:Antithrombins; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D065427:Factor Xa Inhibitors; D005260:Female; D015309:Glucose Clamp Technique; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D007700:Kinetics; D008297:Male; D012016:Reference Values
D000991:Antithrombins; D065427:Factor Xa Inhibitors; D000990:Antithrombin III; D006493:Heparin