An inversion truncating the creA gene of Aspergillus nidulans results in carbon catabolite derepression.
The creAd-30 mutation leading to carbon catabolite derepression in Aspergillus nidulans is a pericentric inversion, having one breakpoint within the creA gene on the left arm of chromosome I and the other breakpoint between binG and yA on the right arm. The left-arm breakpoint alters the creA transcript. The likelihood that the inversion truncates creA centrally strengthens a previous proposal that derepression is the phenotype of loss-of-function mutations in creA.
Department of Bacteriology, Royal Postgraduate Medical School, London, UK.
H N
HN
Arst
D
D
Tollervey
C E
CE
Dowzer
J M
JM
Kelly
D001233:Aspergillus nidulans / Q000187:drug effects / Q000235:genetics*; D007446:Chromosome Inversion; D015825:Chromosomes, Fungal / Q000648:ultrastructure; D005800:Genes, Fungal; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D015183:Restriction Mapping; D014158:Transcription, Genetic
D012333:RNA, Messenger