Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity.
A new antibacterial antibiotic, designated simaomicin alpha (LL-D42067 alpha) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin alpha demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.
Maiese
W M
WM
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
Korshalla
J
J
Goodman
J
J
Torrey
M J
MJ
Kantor
S
S
Labeda
D P
DP
Greenstein
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D002645:Chickens / Q000469:parasitology; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology* / Q000627:therapeutic use; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007546:Isoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D015394:Molecular Structure; D009618:Nocardiaceae / Q000145:classification / Q000378:metabolism*; D011201:Poultry Diseases / Q000188:drug therapy*; D012988:Soil Microbiology
D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D007546:Isoquinolines; C066125:simaomicin alpha