Effects of arterial infusions of adenosine 5'-triphosphate (ATP) and vasoactive intestinal polypeptide (VIP) on vagal excitatory motor responses in the rabbit stomach 'in vivo'.
In the rabbit stomach 'in vivo' adenosine and adenosine 5'-triphosphate depressed the contractile activity elicited by vagal stimulation. The order of potency was ATP greater than adenosine. Only ATP completely blocked the excitatory motor responses. Vasoactive intestinal polypeptide injected close-arterially scarcely affected the vagal contractile activity of the stomach.
Department of Physiology, University of Florence, Italy.
M C
MC
Baccari
F
F
Calamai
G
G
Staderini
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006145:Guanethidine / Q000494:pharmacology; D007261:Infusions, Intra-Arterial; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D011817:Rabbits; D013270:Stomach / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D001285:Atropine; D000255:Adenosine Triphosphate; D000241:Adenosine; D006145:Guanethidine