A theoretical approach to describe monolayer-liposome lipid interaction.
It is known from several studies on the interaction between membrane models that mechanisms such as fusion or lipid exchange can play an important role in the process of internalization by cells of lipid vesicles and also in the physical stability of liposomes. In this paper it is shown that a simple monolayer-liposome model can be used to simulate experimentally observed interactions between lipid vesicles and cell surfaces. From experimental data, a simple theoretical model is formulated to interpret the variation with time of surface pressure as a function of liposome concentration. The congruency of the physico-chemical hypothesis and its validity are studied and correlated with results from experimental systems.
Unit of Physical Chemistry, Facultat de Farmàcia, Universitat de Barcelona, Spain.
J
J
Hernandez-Borrell
F
F
Mas
J
J
Puy
D002118:Calcium / Q000494:pharmacology; D008081:Liposomes / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D008567:Membranes, Artificial; D008954:Models, Biological; D013499:Surface Properties
D008081:Liposomes; D008563:Membrane Lipids; D008567:Membranes, Artificial; D002118:Calcium