Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033.
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D000477:Alkylating Agents / Q000633:toxicity*; D000478:Alkylation; D000818:Animals; D002478:Cells, Cultured / Q000201:enzymology; D004247:DNA / Q000187:drug effects; D004260:DNA Repair; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D010641:Phenotype; D013379:Substrate Specificity; D009626:Terminology as Topic; D014162:Transfection
D000477:Alkylating Agents; D004247:DNA; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase