Two-event model for carcinogenesis: biological, mathematical, and statistical considerations.
A two-mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time-dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.
Moolgavkar
S H
SH
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Luebeck
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G
D000818:Animals; D002274:Carcinogens, Environmental; D004307:Dose-Response Relationship, Radiation; D004812:Epidemiologic Methods; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D011886:Radon / Q000633:toxicity; D051381:Rats; D012306:Risk
D002274:Carcinogens, Environmental; D011886:Radon