The pharmacokinetics of agents used to treat status epilepticus.
A thorough understanding of the pharmacologic properties of lipid-soluble drugs is essential when using these agents to treat status epilepticus. In addition to physiologic factors, such as blood pressure and cerebral blood flow, pharmacokinetic principles, including half-life, distribution, elimination, and volume of distribution (with special regard to an agent's lipid-solubility rating), should be applied. These factors, in toto, will influence the choice of drug, its loading dose, and its therapeutic dose.
Department of Neurology and Pharmacology, Boston University School of Medicine, MA.
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Browne
D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003975:Diazepam / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007273:Injections, Intramuscular; D050356:Lipid Metabolism; D010634:Phenobarbital / Q000008:administration & dosage / Q000493:pharmacokinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D012995:Solubility; D013226:Status Epilepticus / Q000188:drug therapy*
D000927:Anticonvulsants; D010672:Phenytoin; D003975:Diazepam; D010634:Phenobarbital