Multicentric reticulohistiocytosis. Detailed immunophenotyping confirms macrophage origin.
A case study of multicentric reticulohistiocytosis is presented with extensive immunohistochemical studies of the infiltrate in both paraffin and cryostat sections. These studies showed that the cells are of monocyte/macrophage origin. B- and T-cell gene rearrangement analysis of multicentric reticulohistiocytosis was also performed and showed a germline configuration.
Department of Morbid Anatomy, King's College Hospital, London, England.
J R
JR
Salisbury
P A
PA
Hall
H C
HC
Williams
M H
MH
Mangi
G J
GJ
Mufti
D002460:Cell Line; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007158:Immunologic Techniques; D008264:Macrophages / Q000473:pathology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype