Dentinal permeability in assessing therapeutic agents.
The measurement of dentinal permeability has been useful in confirming the mechanism of the hydrodynamic hypothesis for pain transmission in hypersensitive patients, has advanced our understanding of how neural agents can reach the pulpal nerves, and has provided useful data to compare and evaluate therapeutic agents. Methods to assess permeability have varied from direct dye penetration techniques to measurement of fluid flow through dentin sections to SEM photography of impression replicas in vivo. A number of clinical therapeutic strategies have emerged from this work as well as ways to mitigate the progressive nature of the condition.
Research and Development Laboratories, Block Drug Company, Jersey City, New Jersey.
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D003804:Dentin / Q000378:metabolism / Q000648:ultrastructure; D003806:Dentin Permeability / Q000187:drug effects; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D014088:Tooth Permeability / Q000187:drug effects