Glycine, glycyl-glycine and maltodextrin based oral rehydration solution. Assessment of efficacy and safety in comparison to standard ORS.
We evaluated the efficacy and safety of an oral rehydration solution containing glycyl-glycine, glycine, and maltodextrin (GGG-ORS), in comparison to the glucose based ORS (standard ORS). The osmolality of the GGG-ORS (305 mOsm/l) and standard ORS (311 mOsm/l) was similar. Ninety-two children presenting with acute gastroenteritis and moderate dehydration, aged 3 months to 3 years, were randomly assigned to receive standard ORS or GGG-ORS. All the patients were successfully rehydrated orally. The two groups were comparable for baseline characteristics including the microbial etiology. Rotavirus (49%, 36%), ETEC (11%, 18%) or a combination of rotavirus and ETEC (15%, 9%) were the main stool pathogens isolated. There was no significant difference in the mean stool output or duration of diarrhoea between the two groups. Patients in the GGG-ORS group had higher urine output (p less than 0.01) and weight gain (p less than 0.05) in the initial 6 hours when feeding was withheld, but no such differences were observed beyond this period. Hypernatremia did not develop in any patient during the study. We conclude that glycine and glycyl-glycine supplemented oral rehydration solution does not have any therapeutic advantage in the treatment of acute gastroenteritis with moderate dehydration caused predominantly by rotavirus.
Bhan
M K
MK
Division of Pediatric Gastroenterology and Enteric Infections, All India Institute of Medical Sciences, New Delhi.
Sazawal
S
S
Bhatnagar
S
S
Bhandari
N
N
Guha
D K
DK
Aggarwal
S K
SK
D000208:Acute Disease; D002675:Child, Preschool; D003681:Dehydration / Q000209:etiology / Q000628:therapy*; D004311:Double-Blind Method; D005440:Fluid Therapy / Q000379:methods*; D005759:Gastroenteritis / Q000150:complications / Q000628:therapy*; D005998:Glycine / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D015532:Rehydration Solutions / Q000627:therapeutic use*
D011134:Polysaccharides; D015532:Rehydration Solutions; C008315:maltodextrin; D005998:Glycine