Dopamine and natriuresis. Mechanism of action and developmental aspects.
The present paper summarizes our studies on the mechanisms of the dopamine induced changes in renal macro- and microcirculation as well as in proximal and distal tubular sodium handling which contributes to the natriuresis induced by the drug. Some aspects of the physiological role of locally generated dopamine in regulating sodium excretion are also reviewed. Finally, by describing the cardiovascular, renal and hormonal effects of dopamine in the preterm human neonate, some of the developmental aspects of the renal effects of the drug are also discussed.
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Harvard Medical School, Joint Program in Neonatology, Boston, MA.
D000818:Animals; D001696:Biomechanical Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology* / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn / Q000652:urine; D007684:Kidney Tubules / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects; D011954:Receptors, Dopamine / Q000145:classification / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects; D014664:Vasodilation
D011954:Receptors, Dopamine; D004298:Dopamine