Inhibitory action of peony root extract on the mutagenicity of benzo[a]pyrene.
The inhibitory effects of peony root extract on the mutagenicity of benzo[a]pyrene (B [a]p) have been investigated in the Salmonella typhimurium reversion test. Four kinds of experiments were performed: direct chemical reaction (1) between peony root extract and B [a]p, and (2) between peony root extract and active metabolite(s) of B [a]p, (3) inhibition of metabolic processes of B[a]p with S9 mix, and (4) inhibition of activation on mutagenicity. Peony root extract interfered with the action of enzymes in the S9 mix, and inactivated the activity of B[a]p metabolites. The bio-antimutagenic effect was assayed by reversion in Salmonella typhimurium TA98 and TA100.
Sakai
Y
Y
Gifu Prefectural Institute of Public Health, Japan.
Nagase
H
H
Ose
Y
Y
Kito
H
H
Sato
T
T
Kawai
M
M
Mizuno
M
M
D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D010936:Plant Extracts; D001564:Benzo(a)pyrene