Acute respiratory failure after intrathecal methotrexate administration.
This is a report of a case of acute respiratory failure following the administration of intrathecal methotrexate (MTX) for prophylaxis of central nervous system leukemia (CNS) in a 3-year-old girl with acute lymphoblastic leukemia. This could be attributed to acute metabolic or direct toxic effects of methotrexate to the central nervous system tissue. Although the specific agent responsible for this complication following intrathecal injection of MTX is unclear, it is worthwhile to describe this event.
Martins da Cunha
A C
AC
St. Anna Children's Hospital, Vienna, Austria.
Bartsch
C H
CH
Gadner
H
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007278:Injections, Spinal / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D013713:Teniposide / Q000008:administration & dosage
D003561:Cytarabine; D004317:Doxorubicin; D003520:Cyclophosphamide; D013713:Teniposide; D008727:Methotrexate