Mechanisms of tumor-associated edema: a review.
An understanding of the mechanisms responsible for tumor-associated edema involves the elucidation of the role played by a number of intra-related processes. These include (i) the permeability of new tumor microvessels that are associated with tumor angiogenesis; (ii) alterations in microvascular permeability due to factors secreted by tumor cells; (iii) immunological mechanisms and (iv) increased microvessel permeability associated with inflammation. The rationale for a role for inflammatory processes in tumor-associated edema has been outlined and the role of non-steroidal anti-inflammatory drugs in modulating experimental and human tumor-associated edema has been explored.
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
R F
RF
Del Maestro
J F
JF
Megyesi
C L
CL
Farrell
D000818:Animals; D001929:Brain Edema / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000098:blood supply / Q000150:complications* / Q000276:immunology; D006801:Humans; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains