The myth of the final hazard assessment.
Hazard assessment is a basic tool used in the evaluation and regulation of chemicals, but in spite of this there are many different interpretations of the scope and function of a hazard assessment. Starting from a discussion of the essential elements and conceptual frames involved, an attempt is made to identify the sources of uncertainty that are inherent in a hazard assessment. Problems identified include unambiguous identification of the chemical source, the routes of exposure, and the possible targets to be considered. Inadequacies in effects data are frequent, but unlike many of the other sources of uncertainty, these are often compensated for by the use of safety factors when setting quantitative limits for human or environmental exposure. The inherent uncertainties in the process make periodic revisions of any hazard assessment process inevitable, as new knowledge on routes of exposure and targets becomes available.
Hart
J W
JW
National Agency of Environmental Protection, Copenhagen K, Denmark.
Jensen
N J
NJ
D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity; D006262:Health; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors; D014116:Toxicology / Q000592:standards*
D004785:Environmental Pollutants