Anaphylactoid reaction to ethanol.
We studied a 14-year-old boy who developed a pruritic rash and facial swelling after ingestion of beer or wine. A blinded challenge with purified ethanol was positive demonstrating ethanol itself to be the offending agent. An IgE-mediated reaction to ethanol or one of its metabolites as a hapten is possible, or the reaction may involve unusual metabolism of ethanol with accumulation of acetaldehyde and/or direct mast cell degranulation.
Kelso
J M
JM
Mayo Clinic, Rochester, Minnesota.
Keating
M U
MU
Squillace
D L
DL
O'Connell
E J
EJ
Yunginger
J W
JW
Sachs
M I
MI
D000293:Adolescent; D000707:Anaphylaxis / Q000139:chemically induced*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male
D000431:Ethanol