[Inflammatory reaction and laboratory tests: interleukin-1].
Recent progress on the study of IL 1 is summarized and depicted, particularly emphasizing the variety of IL 1 function, and the role of other cytokine inducers. While it has been established that IL 1 has a variety of biological functions in vitro and in vivo, some of these functions are not a direct action of IL 1, but may be ascribed to some other cytokines induced by IL 1, since IL 1 can induce IL 6 (as an inducer of acute phase protein), IL 8 (as a neutrophil chemotactic factor), or IL 1 itself. Other important functions of IL 1 in vivo including resistance to bacterial infection, radioresistance and anti-tumor activity are of great interest to determine whether its action is direct or indirect through the induction of other factors, although the importance of IL 1 yet remains. Finally, the bioassay and ELISA assay of IL 1 alpha and IL 1 beta were established. The IL 1 level in serum, amniotic fluids, and synovial fluids from rheumatoid arthritis have been determined and its biological significance has been discussed.
Department of Medical Biology and Parasitology, Jichi Medical School, Tochigi pref.
T
T
Kasahara
T
T
Akaboshi
H
H
Tsunoda
K
K
Onozaki
Y
Y
Yamagishi
D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D007375:Interleukin-1 / Q000032:analysis* / Q000502:physiology
D007375:Interleukin-1