Insulin induces cell adhesion and normal flattened morphology in Krebs II ascites tumour cells.
Insulin induced Krebs II ascites cells to attach to the substratum and to adopt a flattened morphology associated with normal adhesion and movement. The changes were associated with a reorganization of cellular actin. The results show that insulin has important effects on cell structure and morphology. Insulin may thus be involved in the nutritional control of normal and malignant growth.
Department of Biochemistry, University of Bergen, Norway.
I F
IF
Pryme
J E
JE
Hesketh
D000199:Actins / Q000032:analysis; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D003599:Cytoskeleton / Q000032:analysis / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured / Q000166:cytology*
D000199:Actins; D007328:Insulin