Susceptibility to HIV infection and AIDS in Italian haemophiliacs is HLA associated.
We compared the frequencies of HLA antigens in two matched groups of 31 HIV-seronegative and 31 HIV-seropositive haemophiliacs, exposed during the years 1981-85 to comparable amounts and batches of presumably infectious clotting factor concentrates. The frequency of A2 was significantly higher in HIV-seropositive than in seronegative haemophiliacs, with a relative risk (RR) of seroconversion of 3.92, whereas both Bw52 and DR4 were negatively associated with it. We also studied the distribution of HLA antigens in a larger group of 76 HIV-seropositive haemophiliacs, who were at different clinical stages of HIV infection (CDC classes II-IV) but were comparable for age and time elapsed since seroconversion. DR3 and DQw2 antigens were, particularly when concomitantly present, associated with a high risk of developing symptomatic HIV infection (RR = 11.79 and 25.33). Our data suggest that the HLA region controls susceptibility to infection with HIV and its progression to symptomatic disease in Italian haemophiliacs.
Fabio
G
G
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Smeraldi
R S
RS
Gringeri
A
A
Marchini
M
M
Bonara
P
P
Mannucci
P M
PM
D000293:Adolescent; D000328:Adult; D002648:Child; D004198:Disease Susceptibility; D006679:HIV Seropositivity / Q000150:complications* / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006467:Hemophilia A / Q000150:complications* / Q000235:genetics / Q000276:immunology; D002836:Hemophilia B / Q000150:complications / Q000276:immunology; D006801:Humans; D008875:Middle Aged
D006680:HLA Antigens