[Amiodarone and thyroid: the Janus effect].
Iodide released from Amiodarone during a chronic treatment is 100 x higher than food iodide intake. Thyroid adaptation allows normal function but over-adaptation leads to hypothyroidism and hypo-adaptation to thyrotoxicosis. Thyrotoxicosis may also result from follicular disruption. Amiodarone inhibits 5' deiodinase type I and II and hence increases serum T4 and (transiently) TSH and decreases serum T3 concentrations. Perchlorate and corticoids may be useful in the treatment of thyrotoxicosis.
Unger
J
J
Service d'Endocrinologie, Clinique Universitaires de Bruxelles, Hôpital Erasme, U.L.B.
D000222:Adaptation, Physiological; D000638:Amiodarone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007455:Iodine / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism
D013963:Thyroid Hormones; D007455:Iodine; D000638:Amiodarone
Amiodarone et thyroïde: l'effet Janus.