Evaluation of olestra in short-term genotoxicity assays.
Olestra, a mixture of hexa-, hepta- and octa-esters formed from the reaction of sucrose with long-chain fatty acids, was evaluated for its genotoxic potential in the Salmonella/mammalian microsome test, the L5178Y thymidine kinase (TK+/-) mouse lymphoma assay, an unscheduled DNA synthesis assay in primary rat hepatocytes, and an in vitro cytogenetic assay in Chinese hamster ovary cells. The results indicated that olestra was non-genotoxic in these assays.
Skare
K L
KL
Procter & Gamble Company, Shelton, CT 06484.
Skare
J A
JA
Thompson
E D
ED
D000818:Animals; D001711:Biotransformation; D002460:Cell Line; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D005227:Fatty Acids / Q000378:metabolism / Q000633:toxicity*; D066298:In Vitro Techniques; D007940:Leukemia L5178 / Q000235:genetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics; D013395:Sucrose / Q000378:metabolism / Q000633:toxicity* / Q000031:analogs & derivatives; D014407:Tumor Cells, Cultured
D005227:Fatty Acids; D009153:Mutagens; D013395:Sucrose; C013692:sucrose polyester; D004247:DNA