Blood coagulation and fibrinolysis: an overview.
Recent advances in the understanding of blood coagulation provide strong evidence that exposure of tissue factor is the "match" which initiates blood coagulation. A novel plasma protease inhibitor, called EPI or LACI, effectively extinguishes this "match," leaving Factors IXa, VIII, X, V, and II to function as a "fuse." Activated Factors IX, X, and II are controlled by heparin-enhancable protease inhibitors. Activated Factors VIII and V are destroyed by the protein C/S system. Fibrinolysis is largely cell-based and controlled by differential secretion of plasminogen activators and plasminogen activator inhibitors.
Department of Medicine, University of Wisconsin, Madison 53706.
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Mosher
D001777:Blood Coagulation / Q000502:physiology*; D005167:Factor VII / Q000037:antagonists & inhibitors / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000378:metabolism
D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D005167:Factor VII; D013925:Thromboplastin