Effects of baroreceptor denervation on endocrine and drinking responses to caval constriction in dogs.
Plasma arginine vasopressin (AVP), plasma renin activity (PRA), and water intake (H2OIN) are increased by thoracic inferior vena caval constriction (TIVCC). To assess the role of the cardiac and sinoaortic baroreceptors in these responses, 9 sham-, 10 cardiac-(CD), 6 sinoaortic-(SAD), and 4 combined cardiac and sinoaortic-(CD + SAD) denervated conscious dogs were studied. All animals were studied while normally hydrated 1) with no access to water (H2O-) and 2) while drinking was permitted (H2O+). TIVCC caused similar reductions (P less than 0.001) of mean arterial (-32 +/- 4 mmHg), left atrial pressure (-6.5 +/- 1.1 cmH2O), and right atrial pressure (-4.2 +/- 0.8 cmH2O) in all groups. After TIVCC in sham dogs with H2O-, AVP increased from 3.6 +/- 0.7 to 72.8 +/- 12.6 pg/ml (P less than 0.001). AVP was similar with SAD (57.1 +/- 6.9) but was reduced with CD (30.9 +/- 3.0) and CD + SAD (17.7 +/- 4.0). In all groups, PRA increased from 4.5 +/- 0.7 to 23.8 +/- 3.0 ng.ml-1 x 3 h-1 and plasma angiotensin II (ANG II) increased from 14.0 +/- 2.8 to 59.5 +/- 13.0 pg/ml (P less than 0.001). Plasma adrenocorticotropic hormone (ACTH) increased similarly in all groups (55 +/- 5 to 128 +/- 25 pg/ml). Plasma norepinephrine (NE) levels increased similarly in all groups (298 +/- 61 to 654 +/- 88 pg/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Physiology, University of California, San Francisco 94143.
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Quillen
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Keil
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Reid
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood; D003250:Constriction; D003714:Denervation; D004285:Dogs; D004326:Drinking / Q000502:physiology*; D004702:Endocrine Glands / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006325:Heart Atria; D006339:Heart Rate; D011311:Pressoreceptors / Q000502:physiology*; D012083:Renin / Q000097:blood; D014684:Venae Cavae / Q000502:physiology*
D002395:Catecholamines; D000804:Angiotensin II; D001127:Arginine Vasopressin; D012083:Renin