Drug-induced parkinsonism and other movement disorders.
This is a review of reserpine, haloperidol, and various phenothiazines that produce parkinsonism and other movement disorders. The by-products of illicit meperidine synthesis, MPTP and its more sinister companion, MPP, are also discussed. Movement disorders, transient or fixed, frank parkinsonism and/or dyskinesia, due to a variety of other medications and toxic agents are included. These are methanol, lithium, methyldopa, antimetabolites, antidepressants, sympathomimetic anorexiants, some types of antihistamines, and various combinations of agricultural chemicals.
Ross
R T
RT
Department of Medicine, University of Manitoba, Winnipeg, Canada.
D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D020267:MPTP Poisoning; D009069:Movement Disorders / Q000209:etiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D010640:Phenothiazines / Q000009:adverse effects*; D012110:Reserpine / Q000009:adverse effects*
D010640:Phenothiazines; D012110:Reserpine; D006220:Haloperidol