The effect of diverting colostomy on anastomotic healing after resection of left colon obstruction. An experimental study in the rat.
A standardized stenosis of the left colon was created in the rat model. After four days the stenosis was resected and a primary anastomosis made. Half of the animals (n = 21) were randomized to a proximal diverting colostomy and the other half to a non-colostomy control group. On postoperative days two and seven anastomotic complications were recorded and anastomotic strength was determined. Collagen content in the anastomotic area was measured. In the colostomy group no anastomotic complications occurred, while 6/21 (29%) animals in the non-colostomy group had complications. On day two there was no difference between the groups as regards anastomotic strength and collagen content. After a week, however, the control group showed a significant increase in both anastomotic strength and collagen content which was not observed in the colostomy group. The absence of increase in anastomotic strength in the colostomy group had no adverse effect on anastomotic healing, as judged by complications. Thus, a diverting colostomy may be of value in reducing anastomotic complications after resection of a left colon obstruction.
Department of Surgery and Experimental Research, Lund University, Malmö General Hospital, Sweden.
A
A
Törnqvist
P
P
Blomquist
H
H
Jiborn
B
B
Zederfeldt
D000714:Anastomosis, Surgical; D000818:Animals; D003094:Collagen / Q000032:analysis; D003108:Colonic Diseases / Q000601:surgery*; D003125:Colostomy; D007415:Intestinal Obstruction / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000502:physiology*
D003094:Collagen