The transforming growth factor-betas. A new family of immunoregulatory molecules.
Within the past three years there has been a rapid expansion in our knowledge of the role TGF-beta mediates in regulating immune responses in vitro. Whether the TGF-beta will be clinically useful to suppress immune responses to transplanted organs or autoimmune responses is unknown. However, now that highly purified quantities of TGF-beta are available through recombinant DNA technologies, questions concerning the in vivo immunosuppressive activities of TGF-beta can be answered.
Palladino
M A
MA
Genentech, Inc., South San Francisco, California 94080.
Morris
R E
RE
Starnes
H F
HF
Levinson
A D
AD
D000818:Animals; D006084:Graft Rejection; D006801:Humans; D008213:Lymphocyte Activation; D012772:Shock, Septic / Q000503:physiopathology; D015291:Transforming Growth Factors / Q000502:physiology*
D015291:Transforming Growth Factors