Refinements in the coating of urethral catheters reduces the incidence of catheter-associated bacteriuria. An experimental and clinical study.
The tendency to develop bacteriuria during the use of various forms of indwelling catheters was evaluated in a randomized trial in 90 patients. A silver alloy and hydrogel-coated Foley catheter (SHC) was compared to a non-coated catheter (NC) and a catheter coated only with hydrogel (HC). Three patients (10%) with SHC catheters, 10 (33%) patients with HC catheters, and 15 (50%) patients with NC catheters developed bacteriuria (greater than 10(5) organisms/ml). The difference in the rate of bacteriuria after 5 days of catheterization was statistically significant between the SHC catheter and the NC catheter (p less than 0.002). There was no significant difference between the SHC catheter and the HC catheter, nor was there a significant difference between the HC catheter and the NC catheter. The toxic effects, as estimated by the IC50 value, of the urinary catheter material used was elucidated in an experimental fibroblast model. The IC50 value for the NC catheter was 33.9%, HC catheter 72.2% and for the SHC catheter 98.1%.
Department of Urology, Karolinska Hospital, Stockholm, Sweden.
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H
Liedberg
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T
Lundeberg
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P
Ekman
D001437:Bacteriuria / Q000517:prevention & control*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D016032:Randomized Controlled Trials as Topic; D012834:Silver; D014546:Urinary Catheterization / Q000009:adverse effects* / Q000295:instrumentation
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012834:Silver; D011092:Polyethylene Glycols