Amphotericin B O-methyl oxime. Synthesis and biological properties.
Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity.
Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
A
A
Czerwiński
W A
WA
König
P
P
Sowiński
L
L
Falkowski
J
J
Mazerski
E
E
Borowski
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012441:Saccharomyces cerevisiae / Q000187:drug effects
C066130:amphotericin B O-methyloxime; D000666:Amphotericin B