Cleaved and multilobated cell immunocytoma of low grade malignancy with amyloid. An immunohistochemical and electron microscopical study.
An unusual variant of immunocytoma of low grade malignancy, cytologically resembling follicular cleaved-cell malignant lymphoma is described. Presence of heavy deposits of amyloid, intracytoplasmic monoclonal IgM-kappa immunoglobulin, cells with Dutcher inclusions, electron-microscopic features and negativity of T-cell markers led to diagnosis of immunocytoma. After cytostatic chemotherapy the lymphoma changed its morphology into typical lymphoplasmacytoid immunocytoma.
Department of Pathological Anatomy, KUNZ, Pilsen, Dobŕany.
M
M
Michal
V
V
Koza
D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D001365:Axilla; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D008224:Lymphoma, Follicular / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure