[Is a pharmacological treatment of liver cirrhosis possible?].
Loss of hepatic function is the limiting factor in survival of patients with cirrhosis. Fibrogenesis, cytolysis/necrosis and sinusoidal capillarization, altered composition of biomembranes, and hyporegeneration are identified as major factors in loss of hepatic function. Fibrogenesis has been successfully treated with colchicine. Cytolysis/necrosis in autoimmune hepatitis has for years been treated successfully with steroids: in postviral chronic hepatitis the interferons are showing high promise. Treatment of the other factors is the subject of intensive basic and clinical research.
Reichen
J
J
Institut für Klinische Pharmakologie, Universität Bern.
D004359:Drug Therapy, Combination; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects; D009336:Necrosis
Ist eine pharmakologische Behandlung der Leberzirrhose möglich?