[Group A streptococcal polysaccharide--stimulator of nonspecific cytotoxic reaction in autologous system of spleen cells].
p4 was shown the ability of group A streptococcal polysaccharide (A-PS) to stimulate nonspecific cytotoxic effect of spleen cells on autologous adherent cells (macrophages). The stimulating effect can be observed in vivo under the treatment of spleen cells with A-PS and any antigen (BSA, PPD, M-protein of group A streptococci). In the presence of antigen A-PS can induce nonspecific cytotoxic effect of normal spleen cells (mice CBA, BaLB/c) and of the mice with DHT and therefore these two immunologic phenomena do not depend on each other. Because A-PS has cross-reactive (CR) determinant with thymus epithelial antigen (factor), it can be assumed that via the CR determinant A-PS links with T-cells receptor for this thymus factor and thus realized the stimulating effect as it's functional analogue.
Gnezditskaia
E V
EV
Bazanova
E A
EA
Liampert
I M
IM
Beletskaia
L V
LV
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D008198:Lymph Nodes / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D011135:Polysaccharides, Bacterial
Polisakharid streptokokka gruppy A--stimuliator nespetsificheskikh tsitotoksicheskikh reaktsiĭ v autologicheskoĭ sisteme kletok selezenki.