Cryptococcal skeletal infections: case report and review.
Cryptococcus neoformans is an uncommon but treatable cause of osteomyelitis that affects both normal and immunocompromised hosts. When not considered as a diagnostic possibility, C. neoformans infection may result in increased morbidity. The spectrum of disease at presentation extends from an asymptomatic patient with an osteolytic lesion on radiograph to a patient with signs and symptoms of systemic disease. Once diagnosis has been established (often by closed aspiration), optimal therapy appears to involve a combination of amphotericin B, flucytosine, and surgical debridement.
Department of Internal Medicine, Mt. Sinai Services, City Hospital Center, Elmhurst, New York 11373.
R E
RE
Behrman
J R
JR
Masci
P
P
Nicholas
D003453:Cryptococcosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000382:microbiology*