Effects of CGS 9896 in acute experimental intoxication with fluostigmine.
The therapeutic effectiveness of CGS 9896, a novel potent anxiolytic and anticonvulsant, in organophosphate intoxication was studied. It was demonstrated that this drug, used as an adjunct to a mixture of atropine and obidoxime, led to a rise in the LD50 of fluostigmine in mice of more than 150 times and more than 138 times for 2 and 24 h, respectively. After 24 h, this effect was twice that of diazepam, which served as a reference drug.
Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
S
S
Rump
W
W
Raszewski
T
T
Gidynska
E
E
Galecka
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D007531:Isoflurophate / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D009768:Obidoxime Chloride / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*
D011720:Pyrazoles; D007531:Isoflurophate; D009768:Obidoxime Chloride; C034704:2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one; D001285:Atropine; D003975:Diazepam