[Vitamin D-induced tissue calcinosis and arteriosclerosis changes. I: A contribution to the 60 year history of vitamin D research with special reference to childhood].
Already in 1927, a short time after the detection of the vitamin D, the danger of a hypervitaminosis was put into the field of view. Overdoses of vitamin D may effect calciferous infiltrations in the soft tissue and arteriosclerotic changes. These findings are important especially under consideration of the up-to-now large-dosed vitamin-D-application in the field of the rachitis-prophylaxis. The appearance of nephrocalcinoses could have been demonstrated in predisposed infants and children suffering from disorders in calcium metabolism. In order to optimize the rachitis-prophylaxis in the GDR we comment on the problems and dangers by vitamin-D-overdosages on the basis of animal-experimental and clinical examinations.
Kinderklinik der Friedrich-Schiller-Universität Jena.
G
G
Jahreis
V
V
Hesse
D001161:Arteriosclerosis / Q000209:etiology*; D002114:Calcinosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage / Q000009:adverse effects*
D014807:Vitamin D
Vitamin-D-bedingte Gewebscalcinosen und arteriosklerotische Veränderungen. Teil I: Ein Beitrag zur 60jährigen Geschichte der Vitamin-D-Forschung unter besonderer Berücksichtigung des Kindesalters.