Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid.
Karyometric measurements were performed on fine needle aspirates of clearly identifiable adenomatous areas and adjacent normal-appearing areas in the surgical specimens from ten patients with follicular adenomas of the thyroid. Similar measurements were made on aspirates from nine patients free of thyroid disease. A total of 95 karyometric features were evaluated for each nucleus. Analysis of variance of optical density values did not show a significant difference between the three types of nuclei. Discriminant analysis selected seven karyometric features that produced a statistically highly significant separation of adenoma nuclei from control nuclei. A similar analysis selected six features that produced a statistically highly significant discrimination of normal-appearing nuclei from control nuclei. The validity of these markers for distinguishing control nuclei from adenoma nuclei and normal-appearing nuclei adjacent to adenomas was demonstrated by analysis in further training and test sets. These findings parallel those previously demonstrated for invasive and microinvasive follicular carcinomas of the thyroid.
Lerma-Puertas
E
E
Department of Anatomic Pathology, San Joan Hospital, Reus, Tarragona, Spain.
Galera-Davidson
H
H
Bartels
P H
PH
Kim
D H
DH
Dytch
H E
HE
Bibbo
M
M
D000236:Adenoma / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D013961:Thyroid Gland / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure