[The proteinase activity in the cell nuclei of rats following exposure to gamma radiation and methylnitrosourea].
Activity of nuclear proteinases in blood and liver cells of rats exposed to whole-body gamma-irradiation (10 Gy) has been comparatively studied by the capacity of splitting the casein substrate. Proteinase activity in nuclei of irradiated rat leukocytes was shown to increase by 2.5 times and to gradually decrease after 48 h reaching 150-160% as compared to the control. Two hours following a single injection of methyl nitrosourea the alteration in the activity of proteinases in nuclei of rat hepatocytes and leukocytes was different from the alteration of this index after gamma-irradiation.
L V
LV
Malakhova
G N
GN
Surkenova
A I
AI
Gaziev
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D010450:Endopeptidases / Q000097:blood / Q000378:metabolism*; D005720:Gamma Rays; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D003037:Cobalt Radioisotopes; D008770:Methylnitrosourea; D010450:Endopeptidases
Issledovanie aktivnosti proteinaz v iadrakh kletok krys posle vozdeĭstviia na nikh gamma-radiatsii i metilnitrozomocheviny.