[Inhalation therapy with selective beta 2-sympathomimetic drugs. Effect of pirbuterol administered via the Autohaler and salbutamol administered via the Diskhaler in obstructive respiratory tract disease].
The therapeutic success of salbutamol inhalation with the powder inhalator (Diskhaler) and of pirbuterol with an inhalation-triggered metered aerosol (Autohaler) was determined by comparing the degrees of bronchodilation in 13 patients suffering from chronic obstructive airways disease. Rt and IGV were determined by whole-body plethysmography and FEV1, peak flow and MEF50 by spirometry, and pulse rates were also measured. On average, Rt values decreased by 40 per cent; the other lung function parameters responded correspondingly. Duration of action extended to 4 hours after dosage. Pulse rates and lung functions measured after administration of the products did not differ, either. In such studies as this, whole-body plethysmographic results are superior to those obtained by spirometry.
Medizinische Universitätsklinik, Berufsgenossenschaftlichen Krankenanstalten, Bergmannsheil, Bochum.
H P
HP
Hoffarth
H
H
Freyberger
K P
KP
Völkl
W T
WT
Ulmer
D000328:Adult; D000336:Aerosols; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D011208:Powders; D016032:Randomized Controlled Trials as Topic
D000336:Aerosols; D001993:Bronchodilator Agents; D004983:Ethanolamines; D011208:Powders; C009118:pirbuterol; D000420:Albuterol
Inhalative Therapie mit selektiven beta 2-sympathikomimetika. Wirkung von Pirbuterol im Autohaler und Salbutamol im Diskhaler bei obstruktiver Atemwegserkrankung.