Synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives.
The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
S
S
Nishimura
N
N
Yasuda
H
H
Sasaki
K
K
Kawabata
K
K
Sakane
T
T
Takaya
D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure
D002511:Cephalosporins