[Nerve growth factor as a therapeutic agent: transplantation of brain tissue as a possible treatment of neurodegenerative disorders].
An account of experiments focused on the treatment of neurodegenerative disease by means of cell grafts, in which genetically modified cells that release abundant nerve growth factor are described, and their transplantation to the rat brain reported. The cells can survive in the rat brain and exert potent effects on cholinergic neurons both in the host cortex, basal forebrain and striatum, and in tissue grafts.
Institutionen för miljömedicinsk utvecklingsbiologi, Uppsala biomedicinska centrum, Uppsala universitet.
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Ebendal
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Olson
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Persson
D000818:Animals; D001921:Brain / Q000166:cytology; D002470:Cell Survival; D003704:Dementia / Q000628:therapy; D009410:Nerve Degeneration / Q000502:physiology*; D009414:Nerve Growth Factors / Q000008:administration & dosage* / Q000235:genetics; D009417:Nerve Tissue / Q000637:transplantation*; D051381:Rats
D009414:Nerve Growth Factors
Nervtillväxtfaktor som behandling: transplantation av hjärnvävnad möjlig terapi vid neurodegeneration.