The intrathecal immune response in multiple sclerosis: a different concept of 'specificity'.
A hypothesis is presented in which the immune response in multiple sclerosis is conceived as a primary response to an auto-antigen located within the immune system (e.g. a certain allotype or HLA epitope) which shows subsequent or simultaneous specificity for a greater number of nominal antigens [corrected]. The increased tendency of [corrected] such antibodies to self-aggregation might play a critical role in the pathogenesis.
Lauer
K
K
Department of Neurology, Academic Teaching Hospital, Darmstadi, West Germany.
D001323:Autoantibodies / Q000134:cerebrospinal fluid; D001324:Autoantigens / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000276:immunology; D002678:Chimera; D006801:Humans; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens