Designing hypersensitivity clinical studies.
A dentinal hypersensitivity study is really a clinical pain study. The fundamental difficulties in reproducibly and reliably measuring pain impact heavily on the study. Other critical issues include investigator and subject selection, study design, randomization strategy, study duration, sample size, and statistical analysis. This article discusses principles involved in establishing the efficacy of a desensitizing agent.
Block Drug Company, Jersey City, New Jersey.
G E
GE
Clark
E S
ES
Troullos
D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D012107:Research Design