Inhibition of feeding by ACTH-(1-24): behavioral and pharmacological aspects.
The time course of the behavior of rats fasted for 24 h was analyzed with observation starting either 10 or 60 min after the i.c.v. administration of ACTH-(1-24) (4 micrograms/animal). The anorectic effect of this peptide was direct and specific because it could be dissociated in time from the grooming-inducing effect. The effect is a central one, not linked either to an interaction with the peripheral feeding-regulatory system, or to the release of adrenal steroids. ACTH-(1-24), like corticotropin-releasing factor (CRF), is capable of antagonizing the stimulation of feeding seen during starvation, insulin (10 IU/kg s.c.)-induced hypoglycemia, stimulation of GABAergic (muscimol, 250 ng/rat i.c.v.), noradrenergic (norepinephrine, 20 micrograms/rat i.c.v.) or opioidergic systems. The data suggest that both CRF and ACTH may be considered as putative mediators in the production of stress-induced anorexia.
Institute of Pharmacology, University of Modena, Italy.
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Vergoni
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Poggioli
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Marrama
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Bertolini
D000315:Adrenalectomy; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D007276:Injections, Intraventricular; D007328:Insulin / Q000494:pharmacology; D008297:Male; D008960:Models, Psychological; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D003366:Cosyntropin; D009118:Muscimol