[The use of urapidil in anaesthesia. A selective S1A-serotonin receptor antagonist with antihypertensive action].
Serotonin is a vasoactive amine which is considered to play a pathogenetic role in systemic hypertension on account of the peripharal vasotonic effect of serotonin. The central serotoninergic neurones excitatory influence of the sympathetic tone may, however, be a contributory cause. Urapidil is a selective S1-serotonic receptor-agonist with alpha-blocking effect. This is considered to influence the presynaptic receptors of the serotoninergic neurones and thus to inhibit the excitatory influence on the sympathetic system. It reduces the blood pressure by reducing the peripheral vascular resistance without simultaneous provocation of reflex tachycardia or reduction in the minute volume of the heart. In anaesthesiology, this may be employed for perioperative hypertension. The preparation appears to be particularly useful in neuroanaesthesia as in contrast to other antihypertensive agents, it does not appear to alter the intracranial pressure.
Aalborg Sygehus, Anaestesiologisk/Intensiv Afdeling R.
L H
LH
Nielsen
F
F
Knudsen
A S
AS
Olesen
D000777:Anesthetics / Q000493:pharmacokinetics*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D010879:Piperazines / Q000493:pharmacokinetics; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000627:therapeutic use
D000777:Anesthetics; D000959:Antihypertensive Agents; D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists
Anaestesiologisk anvendelse af urapidil. En selektiv S1A-serotoninreceptoragonist med antihypertensiv virkning.