Pathogenicity of 5-fluorocytosine resistant strains of Candida albicans.
Mutants of Candida albicans blocked in pyrimidine transport and salvage metabolism were produced by a two step mutagenic procedure and selected by their resistance to 5-fluorocytosine (flucytosine). The growth rates and growth yields of these mutants did not differ significantly from the parental strain of C. albicans. Examination of their pathogenicity to mice demonstrated that a defect in the uridine transport function decreased the pathogenicity of C. albicans.
Department of Biochemistry, Cambridge, UK.
M O
MO
Fasoli
D
D
Kerridge
J F
JF
Ryley
D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D002177:Candidiasis / Q000382:microbiology* / Q000401:mortality; D004352:Drug Resistance, Microbial; D005437:Flucytosine / Q000494:pharmacology*; D007668:Kidney / Q000382:microbiology; D007700:Kinetics; D008297:Male; D051379:Mice; D009154:Mutation; D014774:Virulence
D005437:Flucytosine