From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells.
Janssen Research Foundation, Beerse, Belgium.
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Vanden Bossche
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Willemsens
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Bellens
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Roels
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Janssen
D000726:Androgen Antagonists; D000818:Animals; D000935:Antifungal Agents; D002478:Cells, Cultured; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004965:Estrogen Antagonists; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D058886:Sterol 14-Demethylase; D014230:Triazoles / Q000494:pharmacology
D000726:Androgen Antagonists; D000935:Antifungal Agents; C548418:CYP51A1 protein, human; D065607:Cytochrome P-450 Enzyme Inhibitors; D004965:Estrogen Antagonists; D007093:Imidazoles; D014230:Triazoles; C060523:vorozole; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D058886:Sterol 14-Demethylase; C061121:liarozole; D007654:Ketoconazole