Free radicals and antioxidant systems in health and disease.
Free radical (FR) mechanisms have both beneficial and deleterious actions in vivo. Intensive scientific interest in FRs over the last 20 years has led to a clearer understanding of their roles and helped to clarify the contribution of our intrinsic defence systems (antioxidants) in limiting FR-induced tissue damage. As more and more conditions are shown to have a FR aetiology it becomes imperative to develop newer therapies to prevent and treat FR-induced disease.
Sinclair
A J
AJ
Faculty of Medicine and Dentistry, University of Birmingham.
Barnett
A H
AH
Lunec
J
J
D000975:Antioxidants; D001205:Ascorbic Acid / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005609:Free Radicals; D006801:Humans; D007511:Ischemia / Q000201:enzymology; D015227:Lipid Peroxidation / Q000502:physiology; D010587:Phagocytosis / Q000502:physiology; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000502:physiology; D014810:Vitamin E / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E; D013482:Superoxide Dismutase; D001205:Ascorbic Acid