[238Pu body distribution in dogs after intravenous administration and early complexon therapy].
The paper is concerned with the assessment of the level and concentration of 238Pu in different organs and tissues of dogs after iv injection of 238Pu-citrate at the amount of 92.5 kBq.kg-1 and during early complexon therapy. Ninety per cent of Pu detected in the body was shown to be deposited in the skeleton and liver in the ratio 4.5:1. The concentration of 238Pu in per cent to 1 g of tissue in the critical organs (the skeleton, liver, bone marrow) was (28.7--46.9) X 10(-3)%. The concentration of the radionuclide in the organs and tissues regarded as uncritical, was 1-2 orders lower: the endocrine organs--(0.7--7.5) X 10(-3)%, the lymph nodes--(3.8--5.4) X 10(-3)%, the G. I. tract portions--(1.05--1.5) X 10(-3)%, the CNS portions--(0.1--2.0) X 10(-3)%; the kidneys, muscles, heart, spleen and lungs--(0.63--8.8) X 10(-3)%. Early use of octacine or pentacine decreased Pu concentration in all investigated organs and tissues 2 +/- 0.06 times on an average. The efficacy of octacine was no inferior to that of pentacine.
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Sokhranich
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Liubchanskiĭ
D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002951:Citrates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D009930:Organic Chemicals; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000008:administration & dosage; D011005:Plutonium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D002614:Chelating Agents; D002951:Citrates; D009930:Organic Chemicals; D009942:Organometallic Compounds; C061484:octacin; D011005:Plutonium; D004369:Pentetic Acid
Raspredelenie 238Pu v organizme sobak posle vnutrivennogo vvedeniia i ranneĭ kompleksonoterapii.