[The pathogenesis of multiple sclerosis].
Genetic factors determine susceptibility to multiple sclerosis (MS), and environmental factors influence the clinical manifestations of the disease. In recently formed plaques the blood-brain barrier is open for about 6 weeks. Water content is increased in white matter appearing normal macroscopically and in cortex of MS patients. Activated T-lymphocytes accumulate and stimulate microglia and macrophages, which initiate the demyelinating process. In chronic plaques astroglial cells form a scar tissue around axons devoid of myelin. Modern imaging techniques make it possible to differentiate inflammation and demyelination in vivo.
Abteilung für Neurorehabilitation, Rheuma- und Rehabilitationszentrum, Valens.
J
J
Kesselring
D000328:Adult; D000917:Antibody Formation; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D004777:Environment; D006728:Hormones / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009457:Neuroglia / Q000473:pathology
D006728:Hormones
Zur Pathogenese der Multiplen Sklerose.