Are changes in expression of actin genes involved in estrogen-induced cholestasis?
It is postulated that cholestasis associated with high estrogen levels found in women in various conditions, is due to alterations in structure and/or function of the system of actin microfilaments by estrogen-induced changes on expression of actin genes and/or some regulatory actin-binding protein genes. Because bile secretion by hepatocytes is apparently mediated by the microfilamentous system of actin, the proposed hormonally induced dysfunction of this system could be translated to cholestasis.
Facultad de Medicina, Universidad Juárez del Estado de Durango, Department of Biochemistry, México.
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Reyes-Romero
D000199:Actins / Q000235:genetics*; D002779:Cholestasis / Q000139:chemically induced / Q000235:genetics*; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D011247:Pregnancy
D000199:Actins; D004967:Estrogens