Macroglossia and amyloidoma of the buttock: evidence of systemic involvement in dialysis amyloid.
A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the beta 2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy.
Sethi
D
D
Department of Medicine, Charing Cross Hospital, London, UK.
Hutchison
A J
AJ
Cary
N R
NR
Brown
E A
EA
Curtis
J R
JR
Woodrow
D F
DF
Gower
P E
PE
D000682:Amyloid / Q000097:blood / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology*; D002081:Buttocks; D006801:Humans; D008260:Macroglossia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D000682:Amyloid; D001613:beta 2-Microglobulin