New drug treatment for diarrhoea.
This paper reviews the scientific background to the development of new drugs for the treatment of diarrhoeal diseases, and it includes an update of three classes of drugs which may prove useful; gut specific alpha2-adrenergic agonists, intestinal Cl- channel blockers, and somatostatin analogues.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
M
M
Donowitz
S
S
Levine
A
A
Watson
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001692:Biological Transport / Q000502:physiology; D002712:Chlorides / Q000378:metabolism; D003967:Diarrhea / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D000930:Antidiarrheals; D002712:Chlorides; D012964:Sodium