Studies on the determination and degradation of pyrimethamine in mammals.
Treatment of pyrimethamine with blood plasma in vitro yields a metabolite which is also produced when the drug is administered through intravenous injection in the rat. A thin layer liquid chromatographic method for quantitative and qualitative determination of pyrimethamine and its metabolite in plasma and biological tissues is described.
Kumar
R
R
Department of Biosciences and Biotechnology, University of Roorkee, India.
Kaushik
P
P
Sharma
C B
CB
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D008297:Male; D011739:Pyrimethamine / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D051381:Rats
D011739:Pyrimethamine