Increased vascular permeability, erythema, and leukocyte emigration induced in rabbit skin by streptococcal erythrogenic toxin type A.
A highly purified streptococcal erythrogenic toxin type-A (SET-A) caused increased vascular permeability, erythema, and leukocyte emigration when injected into the skin of rabbits. A blueing reaction indicating increased vascular permeability appeared at 1 h, reaching the highest intensity between 4 and 5 h, decreasing thereafter and completely disappearing at 12 h after toxin injection. The intensity of the increase in permeability was found to be dose dependent. The erythematous reaction began later and persisted longer than the blueing. The time course of leukocyte emigration was found roughly to parallel that of the blueing reaction. The skin reaction to SET-A in rabbits can be characterized as having an acute non-specific exudative inflammatory nature.
Department of Microbiology, Saitama College of Health, Japan.
Y
Y
Kamezawa
T
T
Nakahara
Y
Y
Abe
I
I
Kato
D000818:Animals; D001426:Bacterial Proteins; D002199:Capillary Permeability / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced*; D005098:Exotoxins / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects*; D008565:Membrane Proteins; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013297:Streptococcus pyogenes; D013997:Time Factors
D001426:Bacterial Proteins; D005098:Exotoxins; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin