Survey of the use of thrombolysis for acute limb ischaemia in the UK and Ireland.
A total of 156 vascular surgeons from the UK and Ireland responded to a postal questionnaire on the use of thrombolysis in acute limb ischaemia. Almost half had used thrombolysis in the previous 12 months. Low dose intra-arterial streptokinase (89 per cent) was the regimen most frequently used, but 33 per cent had used intravenous streptokinase. Detailed results for 103 patients (limb salvage rate 60 per cent, amputation rate 35 per cent, mortality rate 5 per cent) were similar to those of previously published reports. Complications in most series were infrequent, but in the entire survey there were six bleeding-related deaths and one death from anaphylaxis. A total of 67 per cent of surgeons with working experience indicated that selected patients with acute arterial thromboses were most suitable for thrombolysis, particularly if there was no neurological deficit and no run-off for surgical bypass. Distal or late emboli and graft occlusions were regarded as appropriate by some surgeons. This study demonstrated that many vascular surgeons currently use thrombolysis, although sparingly and in selected cases. Patients with acute limb ischaemia should be managed by experienced vascular surgeons who are aware of the new therapeutic alternatives, an ideal supported by almost three-quarters of respondents to this survey.
Earnshaw
J J
JJ
Department of Surgery, Derriford Hospital, Plymouth, UK.
Shaw
J F
JF
D000208:Acute Disease; D001132:Arm / Q000098:blood supply*; D001291:Attitude of Health Personnel; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007494:Ireland; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D013300:Streptokinase / Q000627:therapeutic use; D013923:Thromboembolism / Q000188:drug therapy; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000706:statistics & numerical data*; D006113:United Kingdom
D013300:Streptokinase