[Effect of cepharanthin on radiotherapy induced leukopenia].
Cepharanthin, a kind of alkaloid, has been reported to show a protective effect for leukopenia induced by radiation therapy. In this study, one of three kinds of drugs, Cepharanthin, S-Adchnon (adrenochrome derivative) and Hythiol (L-cysteine), was randomly administered to 94 patients with cancer of the head and neck, the uterine cervix and the lung, during the course of radiotherapy. When Cepharanthin was given, 81.3% of the patients were protected from leukopenia, compared with 51.6% in S-Adchnon and 32.3% in Hythiol. It is suggested that prophylactic use of Cepharanthin may be useful for cancer radiotherapy.
Department of Radiology, Nagoya City University.
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Ohta
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Morita
D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000470:Alkaloids / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D003545:Cysteine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000188:drug therapy* / Q000209:etiology; D009369:Neoplasms / Q000532:radiotherapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D052117:Benzodioxoles
D000323:Adrenochrome; D000470:Alkaloids; D044182:Benzylisoquinolines; D003545:Cysteine; D011837:Radiation-Protective Agents; C000263:S-Adchnon; C006947:cepharanthine; D052117:Benzodioxoles