Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry.
beta-Hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I have been isolated from the urine of a patient with congenital erythropoietic porphyria by reversed phase high performance liquid chromatography. The compounds were characterized by their chemical behaviour and confirmed by liquid secondary ion mass spectrometry.
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.
R
R
Guo
W
W
Chai
J M
JM
Rideout
A M
AM
Lawson
C K
CK
Lim
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004920:Erythropoiesis; D006016:Glycolates / Q000652:urine*; D006801:Humans; D007773:Lactates / Q000652:urine*; D019344:Lactic Acid / Q000031:analogs & derivatives*; D008297:Male; D013058:Mass Spectrometry; D011164:Porphyrias / Q000097:blood / Q000151:congenital / Q000652:urine*; D014578:Uroporphyrins / Q000652:urine*
D006016:Glycolates; D007773:Lactates; D014578:Uroporphyrins; C031149:glycolic acid; D019344:Lactic Acid; C034103:uroporphyrin I; C031601:hydracrylic acid