Influence of acarbose (a glucosidase inhibitor) on experimental atherosclerosis in the rabbit.
Acarbose, a complex oligosaccharide of microbial origin, was added at levels of 100, 200 or 400 mg/kg to an atherogenic diet fed to New Zealand White rabbits. The rabbits consumed 75 g/day of each diet, thus the daily intake of Acarbose was 7.5, 15 and 30 mg. Rabbits fed 30 mg/day of Acarbose showed reduced levels of plasma cholesterol, intermediate density lipoprotein (IDL) and low density lipoprotein (LDL). Aortic sudanophilia was inhibited by 23% in rabbits fed 7.5 mg/day of Acarbose and by 43% in rabbits fed 15 or 30 mg/day. Acarbose had been shown previously to lower serum cholesterol and triglyceride levels in rats and mice. Our studies demonstrate that it also inhibits atherogenesis in rabbits fed 0.2% cholesterol.
Kritchevsky
D
D
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Tepper
S A
SA
Davidson
L M
LM
Klurfeld
D M
DM
D020909:Acarbose; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D065089:Glycoside Hydrolase Inhibitors; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D014280:Triglycerides / Q000378:metabolism; D014312:Trisaccharides / Q000627:therapeutic use*; D015430:Weight Gain / Q000187:drug effects
D065089:Glycoside Hydrolase Inhibitors; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D014312:Trisaccharides; D002784:Cholesterol; D020909:Acarbose