The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis).
Criteria for the classification of Churg-Strauss syndrome (CSS) were developed by comparing 20 patients who had this diagnosis with 787 control patients with other forms of vasculitis. For the traditional format classification, 6 criteria were selected: asthma, eosinophilia greater than 10% on differential white blood cell count, mononeuropathy (including multiplex) or polyneuropathy, non-fixed pulmonary infiltrates on roentgenography, paranasal sinus abnormality, and biopsy containing a blood vessel with extravascular eosinophils. The presence of 4 or more of these 6 criteria yielded a sensitivity of 85% and a specificity of 99.7%. A classification tree was also constructed with 3 selected criteria: asthma, eosinophilia greater than 10% on differential white blood cell count, and history of documented allergy other than asthma or drug sensitivity. If a subject has eosinophilia and a documented history of either asthma or allergy, then that subject is classified as having CSS. For the tree classification, the sensitivity was 95% and the specificity was 99.2%. Advantages of the traditional format compared with the classification tree format, when applied to patients with systemic vasculitis, and their comparison with earlier work on CSS are discussed.
Masi
A T
AT
University of Illinois College of Medicine, Peoria.
Hunder
G G
GG
Lie
J T
JT
Michel
B A
BA
Bloch
D A
DA
Arend
W P
WP
Calabrese
L H
LH
Edworthy
S M
SM
Fauci
A S
AS
Leavitt
R Y
RY
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications; D015267:Churg-Strauss Syndrome / Q000145:classification* / Q000150:complications / Q000175:diagnosis; D003663:Decision Trees; D004802:Eosinophilia / Q000150:complications; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D008297:Male; D008875:Middle Aged; D012219:Rheumatology / Q000379:methods / Q000639:trends; D012680:Sensitivity and Specificity; D012955:Societies, Medical; D014657:Vasculitis / Q000145:classification