[Persistent spontaneous erythema caused by topical use of fumaric acid monoethyl ester--an obligate mast cell degranulation?].
In 12 healthy volunteers the topical application of monoethyl fumarate caused a spontaneous persistent erythema. Systemic application induced flush. In urticaria pigmentosa the influence was significant higher than in normal skin. This fact suggests a mast cell degranulation caused by monoethyl fumarate.
Hautklinik am Städtischen Klinikum Karlsruhe.
W
W
Gehring
M
M
Gloor
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D015550:Cell Degranulation / Q000187:drug effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005650:Fumarates / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D008875:Middle Aged; D010328:Patch Tests; D016032:Randomized Controlled Trials as Topic; D012882:Skin Tests
D005650:Fumarates; C035088:diethyl fumarate; C061175:ethyl fumarate
Persistierende Spontanerytheme durch topische Anwendung von Fumarsäuremonoethylester--eine obligate Mastzelldegranulation?