Assignment of the gene for beta-spectrin (SPTB) to chromosome 14q23----q24.2 by in situ hybridization.
Type I hereditary spherocytosis results from a molecular defect in the beta-polypeptide of the erythrocyte cytoskeletal protein spectrin. Using a cDNA probe, we had previously assigned the gene for human erythrocyte beta-spectrin (SPTB) to chromosome 14 based upon analysis of its segregation in panels of human x rodent somatic cell hybrids (Winkelmann et al., 1988). Here we report the regional localization of this gene by in situ hybridization to 14q23----q24.2.
Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263.
Y
Y
Fukushima
M G
MG
Byers
P C
PC
Watkins
J C
JC
Winkelmann
B G
BG
Forget
T B
TB
Shows
D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D009693:Nucleic Acid Hybridization; D013049:Spectrin / Q000235:genetics*
D015342:DNA Probes; D013049:Spectrin; D004247:DNA