Thyroid hormone regulation of mitochondrial function. Comments on the mechanism of signal transduction.
Thyroid hormone exerts two types of effect on mitochondria. The first of these is a rapid activation of respiration which takes place within minutes after hormone injection, and is preserved in isolated mitochondria. The second response occurs after 1 to several days of injection and leads to mitochondrial biogenesis and increases in mitochondria mass. The hormone signal for these two responses involves either triiodothyronine (T3)-responsive nuclear genes or a direct action of T3 at mitochondria binding sites.
Nelson
B D
BD
Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D011988:Receptors, Thyroid Hormone / Q000187:drug effects / Q000235:genetics; D015398:Signal Transduction; D014284:Triiodothyronine / Q000494:pharmacology*
D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine