Transplantation of serotonergic neurons into the 5,7-DHT-lesioned rat olfactory bulb restores the parameters of kindling.
In order to restore a normal pattern of kindling, kindled rats, previously lesioned in the olfactory nuclei with 5,7-dihydroxytryptamine, were grafted with serotonin (5-HT) neurons in the right olfactory bulb and then implanted for kindling procedure. It was observed that complete 5-HT lesions accelerated the kindling profile, and that the transplants containing 5-HT neurons restored, in lesioned rats, quite normal parameters.
Laboratoire de Neurobiologie du Développement, INSERM U.249-CNRS UPR 8402, Institut de Biologie, Montpellier, France.
W
W
Camu
L
L
Marlier
M
M
Lerner-Natoli
G
G
Rondouin
A
A
Privat
D015116:5,7-Dihydroxytryptamine; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology / Q000637:transplantation*; D003891:Desipramine / Q000494:pharmacology; D004558:Electric Stimulation; D007696:Kindling, Neurologic; D008297:Male; D009474:Neurons / Q000502:physiology / Q000637:transplantation*; D009830:Olfactory Bulb / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013238:Stereotaxic Techniques
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D003891:Desipramine