Effect of RU 41740 on autologous hemopoietic reconstitution of sublethally irradiated mice.
RU 41740, a glyco-protein extract of Klebsiellae pneumoniae 01 K2 strain, is known to have immunomodulator activities. It acts on macrophages as well as on B and T-cells, and enhances their cytokine production, particularly interleukin 1 (IL-1). The fact that cytokines have an effect on hemopoiesis led us to suspect an effect of RU 41740 on hemopoietic reconstitution. In this study, a model of autologous reconstitution of a hemopoietic system after sublethal irradiation in mice was used. C57 BL/6 mice were treated orally with RU 41740 (10 mg/kg/day) before or after irradiation (6.5 Gy). LPS of Klebsiella pneumoniae was used as a positive control. The hemopoietic reconstitution occurred more rapidly in treated animals especially when RU 41740 was given before irradiation.
Rezzoug
F
F
INSERM U 80 CNRS URA 1177, Hôpital Edouard Herriot, Lyon, France.
Touraine
J L
JL
Zalisz
R
R
Smets
P
P
D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D007711:Klebsiella pneumoniae; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013234:Stem Cells / Q000528:radiation effects; D013997:Time Factors
D001426:Bacterial Proteins; D008070:Lipopolysaccharides; C037567:glycoprotein, Klebsiella pneumoniae