A controlled comparison of piroxicam and diclofenac in patients with osteoarthritis.
Eighty patients with osteoarthritis were randomly assigned to either piroxicam (20 mg daily) or diclofenac (75-150 mg daily) in a 12-week double-blind, parallel groups study. In the 70 patients who completed the study, both medications were effective; statistically significant improvement was observed on all assessments of efficacy. However, no statistically significant differences between the two drugs were seen on any of the efficacy parameters measured. There was a trend towards better tolerance in the piroxicam treated patients, although this was not statistically significant; 3 of the 40 piroxicam treated patients versus 6 of the 40 patients on diclofenac were discontinued from the trial due to intolerable adverse events.
Gerecz-Simon
E
E
Rheumatic Disease Unit, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.
Soper
W Y
WY
Kean
W F
WF
Rooney
P J
PJ
Tugwell
P
P
Buchanan
W W
WW
D000203:Activities of Daily Living; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010894:Piroxicam / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D011795:Surveys and Questionnaires
D010894:Piroxicam; D004008:Diclofenac