Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis.
Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.
Kappel
C A
CA
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611.
Melvold
R W
RW
Kim
B S
BS
D000818:Animals; D003711:Demyelinating Diseases / Q000209:etiology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics; D004680:Maus Elberfeld virus / Q000472:pathogenicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis / Q000209:etiology* / Q000235:genetics; D012737:Sex Factors
D006183:H-2 Antigens