Regional variation within the interphotoreceptor matrix from fovea to the retinal periphery.
The interphotoreceptor matrix in the human retina comprises a highly organised extracellular compartment. Using fluorescent labelled peanut agglutinin and the cationic dyes Cupromeronic and Cuprolinic Blue, unique cylindrical domains surrounding cone photoreceptors can be demonstrated. These cone specific domains are relatively insoluble and are closely adherent to cone photoreceptors and to the pigment epithelium, suggesting that these structures may play a role in retinal attachment.
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
J G
JG
Hollyfield
H H
HH
Varner
M E
ME
Rayborn
D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure*; D005456:Fluorescent Dyes; D005584:Fovea Centralis / Q000648:ultrastructure*; D006801:Humans; D007211:Indoles; D037102:Lectins / Q000378:metabolism; D008266:Macula Lutea / Q000648:ultrastructure*; D009942:Organometallic Compounds; D019887:Peanut Agglutinin; D010786:Photoreceptor Cells / Q000648:ultrastructure*; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D012160:Retina / Q000648:ultrastructure*
D005456:Fluorescent Dyes; D007211:Indoles; D037102:Lectins; D009942:Organometallic Compounds; D019887:Peanut Agglutinin; C015445:copper phthalocyanine