Plasma cell leukemia and hyperviscosity syndrome.
A 56-year-old man had dyspnea, weight loss, hemoptysis, and a generalized bleeding diathesis. Physical examination disclosed hepatosplenomegaly, congestive heart failure, and multiple sites of bleeding. Severe anemia, thrombocytopenia, rouleaux formation, and a leukocytosis with circulating immature plasma cells were observed, along with azotemia, hyperuricemia, and marked elevation of total proteins with a monoclonal IgG kappa spike. The finding of increased serum viscosity confirmed the clinical impression of the hyperviscosity syndrome. Emergency plasma exchange produced marked improvement in the clinical manifestations of hyperviscosity syndrome. Systemic chemotherapy resulted in a partial remission of the disease, but the patient ultimately died of complications of treatment. In this review, we discuss the diagnosis and management of the hyperviscosity syndrome.
Geraci
J M
JM
Department of Medicine, Medical College of Wisconsin, Milwaukee.
Hansen
R M
RM
Kueck
B D
BD
D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity / Q000502:physiology*; D003131:Combined Modality Therapy; D006405:Hematology / Q000295:instrumentation; D006801:Humans; D007952:Leukemia, Plasma Cell / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D010956:Plasmapheresis; D011379:Prognosis; D013577:Syndrome
D001798:Blood Proteins