[Treatment of hemorrhagic cystitis caused by cyclophosphamide using intravesical instillation of potassium alum. Apropos of 5 cases].
Five patients with malignant hemopathies, including four treated by bone marrow transplantation, developed cyclophosphamide-induced hemorrhagic cystitis that failed to respond to the usual treatments. Each was treated by continuous irrigation of the bladder with potassium alum. Hematuria ceased in three patients followed up for 5 to 10 months. A review of the literature confirmed the 75% success rate of this treatment. No local side effects were recorded, but one patient had a single seizure.
Clinique Urologique, Hôpital Tenon, Paris.
B
B
Gattegno
F
F
Guillemenot
P
P
Fiatte
L
L
Cohen
A
A
Becker
E
E
Gluckman
P
P
Thibault
D000283:Administration, Intravesical; D000328:Adult; D000534:Alum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D000535:Aluminum / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006417:Hematuria / Q000188:drug therapy; D006470:Hemorrhage; D006801:Humans; D008297:Male
D000534:Alum Compounds; D003520:Cyclophosphamide; D000535:Aluminum
Traitement des cystites hémorragiques au cyclophosphamide par instillation vésicale d'alun de potassium. A propos de cinq observations.