An electrophysiological study of the ontogenesis of adenosine receptors in the CA1 area of rat hippocampus.
The depressant effect of adenosine (Ad) was studied electrophysiologically in hippocampal slices from 5-, 10-, 15-, 20-, 30- and 120-day-old rats. Ad (10 microM) depressed the field EPSP in CA1 to the same extent in all age groups. Caffeine (Caf), an Ad receptor antagonist, enhanced and nitrobenzylthioinosine (NBI), an Ad uptake blocker, depressed the field EPSP. Both these effects were, however, less prominent in slices from younger animals, a finding consistent with lower extracellular levels of endogenous Ad in neonatal rats.
Department of Physiology, Medical School, University of Patras, Greece.
C
C
Psarropoulou
G
G
Kostopoulos
H L
HL
Haas
D000200:Action Potentials / Q000187:drug effects; D000241:Adenosine / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D013868:Thioinosine / Q000031:analogs & derivatives / Q000494:pharmacology
D011983:Receptors, Purinergic; D002110:Caffeine; D013868:Thioinosine; C001789:4-nitrobenzylthioinosine; D000241:Adenosine