The pharmacokinetics of tricyclic antidepressant drugs in the elderly.
Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is not sufficiently developed. The present paper briefly reviews the available data on amitriptyline, nortriptyline, protriptyline, imipramine, desipramine and clomipramine kinetics in the elderly.
Furlanut
M
M
Department of Pharmacology, University of Padua, Italy.
Benetello
P
P
D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D003863:Depression / Q000188:drug therapy; D006801:Humans
D000929:Antidepressive Agents, Tricyclic