Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene.
The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.
Dragani
T A
TA
Division of Experimental Oncology A. Istituto Nazionale Tumori, Milan, Italy.
Barale
R
R
Parodi
S
S
Taningher
M
M
Zucconi
D
D
Della Porta
G
G
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics; D004247:DNA / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D011725:Pyridines / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
D011725:Pyridines; C028474:1,4-bis(2-(3,5-dichloropyridyloxy))benzene; D004247:DNA