Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults.
The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men. Only trazodone significantly increased deep sleep without otherwise altering the normal architecture of sleep. The alpha-adrenergic receptor-blocking property of trazodone and a relative lack of noradrenergic reuptake blocking and the lack of anticholinergic effects are hypothesized to be responsible for the effects on sleep.
Sleep Disorders Center, Sentara Norfolk General Hospital, VA 23507.
J C
JC
Ware
J T
JT
Pittard
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005712:Galvanic Skin Response / Q000187:drug effects; D006801:Humans; D008297:Male; D010919:Placebos; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy; D012895:Sleep, REM / Q000187:drug effects; D014196:Trazodone / Q000494:pharmacology* / Q000627:therapeutic use; D014299:Trimipramine / Q000494:pharmacology
D010919:Placebos; D014299:Trimipramine; D014196:Trazodone