Epithelioid angiomatosis or cat scratch disease with splenic and hepatic abnormalities in AIDS: case report and review of the literature.
Cat scratch disease (CSD) in the setting of HIV infection is associated with lesions of epithelioid angiomatosis but not with granulomatous lesions seen in the normal host. We report a case of CSD in a patient with AIDS and Kaposi's sarcoma with epithelioid angioma of skin, thrombocytopenia, and abnormalities of liver, spleen, lymph node, and pleura that responded to antimicrobial therapy. We also review reported cases of epithelioid angiomatosis in HIV infections. 12 of these resolved, including 3 without antimicrobial therapy; 18 demonstrated pleomorphic organisms with Warthin-Starry silver stain. Six involved visceral or bony as well as skin lesions. CSD should be considered in the setting of HIV infection with skin nodules even in the presence of biopsy-proven Kaposi's sarcoma. CSD may in these patients be responsible for a variety of disseminated lesions which respond to antimicrobial therapy.
Schwartzman
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WA
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Marchevsky
A
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Meyer
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RD
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000798:Angiomatosis / Q000150:complications / Q000209:etiology* / Q000473:pathology; D002372:Cat-Scratch Disease / Q000150:complications* / Q000473:pathology; D004917:Erythromycin / Q000627:therapeutic use; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000473:pathology; D012782:Shoulder; D012878:Skin Neoplasms / Q000150:complications / Q000209:etiology* / Q000473:pathology; D013154:Spleen / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D005839:Gentamicins; D004917:Erythromycin