[Metabolism of methylglyoxal and malignant neoplasms].
The present notions on the metabolism of methylglyoxal, an endogenic controller of cellular proliferation, are adduced. The interaction between metabolism of methylglyoxal and that of carbohydrates, proteins and lipids is demonstrated. The metabolic chart has been worked out and enzymes catalyzing methylglyoxal metabolic reactions are determined. The effect of methylglyoxal and its bisguanylhydrazones derivatives on the processes of cellular proliferation control has been examined.
Alekseev
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VS
Alekseeva
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NV
D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D011765:Pyruvaldehyde / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D000447:Aldehydes; D000970:Antineoplastic Agents; D011765:Pyruvaldehyde
Metabolizm metilglioksalia i zlokachestvennye novoobrazovaniia.