Hepatopulmonary amoebiasis. Efficacy of various treatment regimens containing dehydroemetine and/or metronidazole.
Thirty three patients with hepatopulmonary amoebiasis were studied. Pulmonary involvement was observed in 55%, pleuro-pulmonary lesions in 30%. Typical chocolate coloured sputum was obtained in 24% and pleural fluid in 21% of patients. Entamoeba histolytica were demonstrable in the sputum in only 6% and in the pleural fluid in 15%. The best therapeutic results were obtained with a combination of dehydroemetine and metronidazole. However, metronidazole was found to be nearly as effective as dehydroemetine, and metronidazole 400 mg and 800 mg were equally effective.
Jain
N K
NK
Hospital for Chest Diseases and Tuberculosis, Sawai Man Singh Medical College, Jaipur.
Madan
A
A
Sharma
T N
TN
Sharma
D K
DK
Mandhana
R G
RG
D000293:Adolescent; D000328:Adult; D000563:Amebicides; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004640:Emetine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008174:Lung Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
D000563:Amebicides; D008795:Metronidazole; C086742:dehydroemetine; D004640:Emetine