Drug-induced parkinsonism and other movement disorders.
This is a review of reserpine, haloperidol, and various phenothiazines that produce parkinsonism and other movement disorders. The by-products of illicit meperidine synthesis, MPTP and its more sinister companion, MPP, are also discussed. Movement disorders, transient or fixed, frank parkinsonism and/or dyskinesia, due to a variety of other medications and toxic agents are included. These are methanol, lithium, methyldopa, antimetabolites, antidepressants, sympathomimetic anorexiants, some types of antihistamines, and various combinations of agricultural chemicals.
Department of Medicine, University of Manitoba, Winnipeg, Canada.
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D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D020267:MPTP Poisoning; D009069:Movement Disorders / Q000209:etiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D010640:Phenothiazines / Q000009:adverse effects*; D012110:Reserpine / Q000009:adverse effects*
D010640:Phenothiazines; D012110:Reserpine; D006220:Haloperidol