Effect of plasma gangliosides on the growth of Ehrlich ascites tumor.
Total plasma gangliosides of Ehrlich ascites tumor-bearing mice enhanced tumor growth when adoptively transferred with the same tumor cells in mice. However, individual gangliosides acted differently. Out of 6 gangliosides separated from plasma, 2 components enhanced tumor growth, whereas the remaining 4 inhibited tumor growth. Neither of the 2 enhancing components in various combinations with the 4 inhibitory components could restore the enhancing effect. The enhancing effect was restored only when both the enhancing components were mixed with the remaining 4 ganglioside components, i.e., with full/complete reconstitution.
Department of Cell Biology, Chittaranjan National Cancer Institute, Calcutta, India.
S
S
Saha
A
A
Ghosh
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000097:blood / Q000502:physiology*; D016233:Immunotherapy, Active; D008297:Male; D051379:Mice
D005732:Gangliosides