[Preliminary studies on the relationship between the blood pressure and renin-angiotensin system in brain and blood vessels in SHRSP].
This work analyzed the relationship between A I concentration in aorta tissue and systolic blood pressure (SBP) in stroke-prone spontaneously hypertensive rats (SHRSP) at different ages. The SBP of SHRSP increased progressively with the age until the age of 20 weeks, when the SBP of SHRSP no longer elevated but sustained at a relatively high and stable level. The A I concentration in aorta of SHRSP was much higher than that of Wistar Kyoto rats at all of the three different ages. Perfusion of captopril into the lateral cerebroventricle of SHRSP for four weeks evoked a considerable decrease of A I concentration in brain as well as a significant reduction of SBP accompanied by a decrement of A I concentration in aorta and concentration of norepinephrine and epinephrine in aorta tissue and plasma. The results further confirm the close relationship between the changed activity of renin-angiotensin system localized in blood vessels during hypertension and the pathogenesis of hypertension, and indicate the possible regulative control of A I generated from central nervous system over the production of A I from blood vessels by means of facilitating the activity of peripheral sympathetic nerve system.
Ding
H
H
Department of Physiology, Tongji Medical University, Wuhan.
Zhou
Q
Q
Deng
J
J
Lo
H Y
HY
Yang
K
K
D000804:Angiotensin II / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology; D004837:Epinephrine / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012084:Renin-Angiotensin System / Q000502:physiology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D002216:Captopril; D009638:Norepinephrine; D004837:Epinephrine