Immunotherapy of tree pollen allergy with a modified alginate conjugated birch pollen extract compared to an aluminium adsorbed extract.
The safety and efficacy of two birch pollen extracts, one chemically conjugated to alginate (Anjuvac) the other adsorbed to aluminium hydroxide (Alutard), were investigated in an open multicentre comparative study of 63 birch pollen allergic patients. Both extracts decreased the nasal symptoms during the birch pollen season. The changes in specific IgE and IgG were much the same in both treatment groups. The adverse reactions recorded were mild in both groups, but more frequent in the Anjuvac group, probably because of a more aggressive dose schedule though there were twice as many asthmatics in the Anjuvac group. The two investigated allergen extracts were useful alternatives for immunotherapy.
Boye
N P
NP
Ullevaal Sykehus, Oslo, Norway.
Salo
O P
OP
Hyldebrandt
N
N
Wihl
J A
JA
Bevan
A
A
Harris
R I
RI
Lovely
J R
JR
D000293:Adolescent; D000328:Adult; D000464:Alginates / Q000008:administration & dosage* / Q000009:adverse effects; D000536:Aluminum Hydroxide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy*; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007167:Immunotherapy / Q000379:methods*; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010936:Plant Extracts / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D011897:Random Allocation; D012537:Scandinavian and Nordic Countries; D012882:Skin Tests / Q000379:methods; D014197:Trees
D000464:Alginates; D007074:Immunoglobulin G; D010936:Plant Extracts; D007073:Immunoglobulin E; D000536:Aluminum Hydroxide