[The postresuscitation changes in the permeability of the hemato-encephalic barrier and their possible pathogenetic significance].
Experiments were conducted on rats with temporary (10-min) clamping of the thoracic vascular bundle and subsequent resuscitation to study the permeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period. Mild increase of BBB permeability was detected 3 minutes after the beginning of recirculation. Permeability increased markedly in 24 hours and continued growing by the 72nd hour. At a 1-3-hour interval in recirculation the BBB was closed. The obtained results disclose the mechanisms of the development of autoimmune cerebral disorders in an organism that experienced cardiac arrest and resuscitation.
I V
IV
Gannushkina
G
G
Weinrauder-Semkow
E A
EA
Mutuskina
A M
AM
Gurvich
M J
MJ
Mossakowski
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000502:physiology*; D001927:Brain Diseases / Q000209:etiology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology; D002463:Cell Membrane Permeability / Q000502:physiology; D005455:Fluorescent Antibody Technique; D006323:Heart Arrest / Q000503:physiopathology; D007136:Immunoglobulins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects; D013997:Time Factors
D001798:Blood Proteins; D007136:Immunoglobulins
Postreanimatsionnye izmeneniia pronitsaemosti gematoéntsefalicheskogo bar'era i ikh vozmozhnoe patogeneticheskoe znachenie.