Effects of the plant flavonoid baohuoside-1 on cancer cells in vitro.
The novel plant flavonoid 3,5,7,-trihydroxy-4'-methoxyl-8'-prenylflavone-3-O-alpha-L-rham nopranoxide (designated baohuoside-1) was shown to have cytotoxic and cytostatic effects on 6 cancer cell-lines, by means of microscopy, 51Cr-release and growth inhibition. The IC50 on the cells tested ranged from 2.8 to 7.5 micrograms/ml. At tumouricidal concentrations, inhibition of DNA and RNA synthesis, but not protein synthesis was observed.
Li
S Y
SY
Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Teh
B S
BS
Seow
W K
WK
Li
F
F
Thong
Y H
YH
D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005419:Flavonoids / Q000633:toxicity*; D006367:HeLa Cells; D006801:Humans; D006922:Hylobates; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; C060988:baohuoside I