Metabolic response to egg white and cottage cheese protein in normal subjects.
In type II diabetic subjects, we previously demonstrated differences in the serum insulin, C-peptide, and glucagon response to ingestion of seven different protein sources when administered with 50 g of glucose. The response was smallest with egg white and greatest with cottage cheese protein. In the present study, we compared the responses to 50 g of the above two proteins ingested without glucose in normal male subjects. We also determined the proportion of each ingested protein converted to urea nitrogen. The incremental area response integrated over 8 hours for serum insulin, C-peptide, glucagon, alpha-amino-nitrogen (AAN), and urea nitrogen were all approximately 50% less following egg white. This was associated with a 50% smaller conversion of protein to urea. Overall, 70% of the cottage cheese but only 47% of the egg white protein could be accounted for by urea formation. Most likely the smaller hormonal response to egg white is due to poor digestibility of this protein.
Nuttall
F Q
FQ
Metabolic Research Laboratory, VA Medical Center, Minneapolis, MN 55417.
Gannon
M C
MC
D000328:Adult; D000607:Aminoacetonitrile / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002096:C-Peptide / Q000097:blood; D003611:Dairy Products; D004044:Dietary Proteins / Q000494:pharmacology*; D004527:Egg Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D013217:Starvation / Q000097:blood; D014508:Urea / Q000652:urine
D001786:Blood Glucose; D002096:C-Peptide; D004044:Dietary Proteins; D004527:Egg Proteins; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D000607:Aminoacetonitrile; D014508:Urea; D005934:Glucagon