Serum lipoproteins during bone marrow hyperplasia after phenylhydrazine administration in rats.
In the present study, lipoprotein metabolism was investigated during compensatory hyperplasia of bone marrow after haemolysis induced by phenylhydrazine (20 mg/kg b.w.) administration in rats. The rats were sacrificed at different time intervals (0, 1, 2 and 5 days) after phenylhydrazine treatment. Analysis of the different fractions of lipoproteins has shown that during bone marrow hyperplasia there is an alteration of lipoprotein profiles, mainly due to a decrease of HDL2 and HDL3 subfractions.
Istituto di Farmacologia e Patologia Biochimica, Università di Cagliari, Italy.
S
S
Dessì
B
B
Batetta
O
O
Spano
D
D
Pulisci
C
C
Anchisi
P
P
Pani
G
G
Broccia
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood*; D006461:Hemolysis / Q000187:drug effects; D006965:Hyperplasia / Q000097:blood; D008297:Male; D010659:Phenylhydrazines; D051381:Rats; D011919:Rats, Inbred Strains
D008076:Cholesterol, HDL; D010659:Phenylhydrazines