[The effect of cyclosporin A on experimental glomerulonephritis in rabbits].
The effect of cyclosporin A on the development of the autologous phase of experimental rabbit glomerulonephritis was assessed. The glomerulonephritis was induced by an intravenous injection of duck anti-rabbit glomerular basement membrane globulin into adult rabbits. After 5-7 days, diffuse proliferative glomerulonephritis with proteinuria and linear glomerular basement membrane deposits of rabbit IgG were observed in all animals. The cyclosporin A treatment was started simultaneously with the injection of duck globulin. This attenuated the glomerular lesion, resulting in a normal urinary excretion. The serum level of anti-duck globulin antibody was reduced. In the group of rabbits, receiving an injection of duck anti-rabbit glomerular basement membrane globulin, cyclosporin A treatment and an additional high dose of rabbit anti-duck globulin 8 days later, equally no glomerulonephritis was observed. However, no effect of cyclosporin A treatment on the duck immunoglobulin induced passive Arthus phenomenon was seen.
St.-Josef-Hospital, Universitäts-Kinderklinik Bochum.
S
S
Kurunczi
M
M
Dzengel
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Z
Hosszu
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3 / Q000652:urine; D003524:Cyclosporins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology; D007074:Immunoglobulin G / Q000652:urine; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D011507:Proteinuria / Q000188:drug therapy; D011817:Rabbits
D003176:Complement C3; D003524:Cyclosporins; D007074:Immunoglobulin G
Die Wirkung von Cyclosporin A auf die experimentelle Glomerulonephritis bei Kaninchen.