Overlap of concanavalin-A and insulin imprinting in rat thymocytes.
The thymocytic insulin binding in rats treated with the hormone neonatally on a single occasion increased considerably compared to the untreated control by 3 months of age. Treatment with Concanavalin-A also accounted for an increase in adult insulin binding, whereas neonatal treatment with insulin did not alter the binding relations of Concanavalin-A in adulthood.
Department of Biology, Semmelweis University Medical School, Budapest, Hungary.
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Csaba
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Köhidai
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D003208:Concanavalin A / Q000378:metabolism / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D007328:Insulin; D003208:Concanavalin A; D011972:Receptor, Insulin