Common antibiotic resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis from human and canine infections.
The plasmids of a multiresistant "canine" Staphylococcus epidermidis-culture were investigated. Two small plasmids, the 4.55 kB chloramphenicol resistance (CmR-) plasmid pSC4 and the 4.45 kB tetracycline resistance (TetR-) plasmid pST 3 could be isolated. Detailed restriction maps of pSC 4 and pST 3 were constructed by double restriction endonuclease digests. The restriction maps revealed extensive structural homologies between pSC 4 from "canine" S. epidermidis and the CmR-plasmid pC 221 from "human" S. aureus as well as between pST 3 from "canine" S. epidermidis and the TetR-plasmid pT 181 from "human" S. aureus. These data suggested that an exchange of small plasmids between S. epidermidis and S. aureus might be possible.
Schwarz
S
S
Institut für Bakteriologie und Immunologie, Justus-Liebig-Universität Giessen.
Cardoso
M
M
Grölz-Krug
S
S
Blobel
H
H
D000818:Animals; D002702:Chloramphenicol Resistance / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D004587:Electrophoresis, Agar Gel; D006801:Humans; D011815:R Factors; D015183:Restriction Mapping; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000235:genetics; D013753:Tetracycline Resistance / Q000235:genetics
D004269:DNA, Bacterial