[Detection of IgA in diseased skin and serum of patients with psoriasis vulgaris].
Origin and function of IgA in the psoriatic skin are unknown. Including a monoclonal antibody against the secretory component (SC) of the secretory IgA (SIga), we have tried to characterize the IgA in psoriasis. With help of a polyclonal antiserum we found depots of IgA in the skin in 69% of all investigated patients. There was a correlation between the degree of akanthosis and the amount of intraepidermal IgA. In the serum of the psoriasis total IgA was significant increased, but never we found SC-bound SIgA in the skin or elevated levels in serum of patients.
Koch
H J
HJ
Hautklinik, Bezirkskrankenhauses Plauen, DDR.
Wollina
U
U
Seyfarth
M
M
Thiel
W
W
Schaarschmidt
H
H
D000328:Adult; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology* / Q000473:pathology
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory
Nachweis von IgA in erkrankter Haut und im Serum von Patienten mit Psoriasis vulgaris.