[The functional characteristics of the interaction of lymphokine-producing lymphocytes with granulocytes of the peripheral blood and skin in dermatosis patients].
PHA-induced mononuclear production of lymphokines altering leukocyte migration was studied in patients with psoriasis, mycosis, and scabies. The findings evidence that T-cells synthesize leukocyte migration inhibition factor (LMIF) in mycosis and scabies, whereas in psoriasis they produce both LMIF and leukocyte migration stimulation factor (LMSF). Blood leukocytes of mycosis and scabies patients were more sensitive to LMIF than the cells of psoriasis patients. The 'skin fenestra' cells (granulocytes) of these patients were functionally active only in respect of LMIF, even when mononuclears synthesized LMSF, this evidencing the participation of skin leukocytes of psoriasis patients in blockage of the functional activity of LMSF-producing immunocompetent cells.
Kozin
V M
VM
Adamenko
G P
GP
Bogdanovich
L I
LI
Iakirevich
E V
EV
D002464:Cell Migration Inhibition; D002630:Chemotactic Factors / Q000097:blood; D003881:Dermatomycoses / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis*; D008264:Macrophages; D011565:Psoriasis / Q000276:immunology; D012532:Scabies / Q000276:immunology; D012867:Skin / Q000276:immunology*; D012871:Skin Diseases / Q000276:immunology*
D002630:Chemotactic Factors; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; C053609:macrophage migration enhancement factor
Funktsional'nye osobennosti vzaimodeĭstviia limfokinprodutsiruiushchikh limfotsitov s granulotsitami perifericheskoĭ krovi i kozhi bol'nykh dermatozami.