[Penetration of the anti-arrhythmia preparation ethmozin through the hemato-encephalic barrier of the guinea pig brain perfused in situ].
In experiment with an artificially perfused guinea-pig brain, labelled ethmosine possessing gamma-activity was used to study the penetration of the drug through the blood-brain barrier. The ethmosine transport constant was found to be in a range of 0.45-0.62 x 10(-3) ml x min-1 x g-1 for various segments of the anterior brain, suggesting that the agent penetrated into the central nervous system very slowly. The slight penetration of ethmosine through the blood-brain barrier may be one of the reasons for this phenothiazine derivative having no marked neurotropic activity.
Zlokovich
B V
BV
Lipovats
M N
MN
Ivanovich
T
T
Aniukhovskiĭ
E P
EP
Rozenshtraukh
L V
LV
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001812:Blood-Brain Barrier / Q000502:physiology*; D002339:Carotid Arteries; D005260:Female; D006168:Guinea Pigs; D007261:Infusions, Intra-Arterial; D008297:Male; D016293:Moricizine; D010477:Perfusion / Q000379:methods; D010640:Phenothiazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D016293:Moricizine
Proniknovenie antiaritmicheskogo preparata étmozina cherez genatoéntsefalicheskiĭ bar'er perfuziruemogo in situ mozga morskoĭ svinki.