[Leu-M1, CEA and intermediate filament proteins in histochemical differential diagnosis of malignant pleural mesothelioma].
The differential diagnosis "pleuramesothelioma" vs "metastatic adenocarcinoma" can mostly not be decided clearly by conventional histological methods in malignant pleuraneoplasias. Leu-M1 is employed in immunhistochemical diagnosis of lymphomas in Hodgkin's disease but it also reacts with adenocarcinoma cells. Pleuramesotheliomas are Leu-M1 negative. Intermediary filament proteins, CEA and Leu-M1 are important "markers" in the diagnosis of malignant pleuraneoplasias. 25 pleura biopsies of malignant pleura processes were subjected to immunhistochemical examination.
Pneumologisch-onkologische Abteilung, Krankenhaus Grosshansdorf.
M
M
Heckmayr
U
U
Gatzmeier
S
S
Schröder
A
A
Niendorf
E
E
Fasske
D000230:Adenocarcinoma / Q000473:pathology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis*; D008654:Mesothelioma / Q000473:pathology*; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000473:pathology*
D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007381:Intermediate Filament Proteins
LEU-M1, CEA und Intermediärfilamentproteine in der histochemischen Differentialdiagnose maligner Pleuramesotheliome.