Insulin secretion in Walker 256 tumor cachexia.
The effect of cachexia on insulin secretion was examined in adult male rats. Isolated islets of Langerhans from Walker 256 tumor-bearing rats secreted less insulin by glucose stimuli as compared with the control group; this was accompanied by significant change in 45Ca2+ outflow rate. Reduced insulin secretion to glucose stimuli in tumor-bearing rats probably led to low insulinemia (one-third). These findings indicate that reduced insulin secretion is probably an important factor for the development of cachexia in Walker 256 tumor-bearing rats.
Department of Physiology and Biophysics, São Paulo University, Brazil.
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Fernandes
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Machado
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Nogueira
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Carpinelli
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Curi
D000818:Animals; D002100:Cachexia / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D007328:Insulin; D005947:Glucose; D002118:Calcium