Cytogenetic studies of human T-cell leukemia virus type I carriers. A family study.
Recently, the chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL), and this anomaly has also been confirmed in the preleukemic state of adult T-cell leukemia (pre-ATL) patients. Because the cytogenetic abnormality at the stage of human T-cell leukemia virus type I (HTLV-I) carrier remains uncertain, we performed cytogenetic studies of lymphocytes stimulated with phytohemagglutinin in three HTLV-I carriers and three non-HTLV-I carriers in an ATL family. As a result, in three HTLV-I carriers, four of 311 cells examined (1.3%) had chromosome 14q11 anomaly. However, in three non-HTLV-I carriers, none of 260 cells examined had chromosome 14q11 anomaly. These results suggest that chromosome 14q11 anomaly is already present at the stage of HTLV-I carrier and seems to be an important cytogenetic clue to the pathogenesis of ATL.
Department of Hematology, Nagasaki University School of Medicine, Japan.
T
T
Itoyama
N
N
Sadamori
S
S
Tokunaga
I
I
Sasagawa
H
H
Nakamura
E
E
Yao
T
T
Jubashi
Y
Y
Yamada
S
S
Ikeda
M
M
Ichimaru
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002869:Chromosome Aberrations / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015458:Leukemia, T-Cell / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology
D010835:Phytohemagglutinins