[Neutrophil chemotaxis. II. Clinical implications and therapeutic indications in children].
Defects of neutrophil chemotaxis are usually accompanied by recurrent or chronic infections of the skin and the respiratory tract. The onset of clinical symptoms may occur early in infancy; infections tend to be severe and they are generally due by organisms which are of relatively low pathogenicity in the healthy subject. Abnormalities of neutrophil chemotaxis were classified and described as humoral, cellular and unclassified defects. The relevance of neutrophil chemotaxis in the single clinical entities was discussed, taking in particular account the most recent views on the argument. Some details on practical and theoretical therapeutic approaches were also reviewed.
Cazzola
G A
GA
Servizio Pediatrico Speciale, Ospedale Civile Maggiore, Verona, Italia.
Valletta
E A
EA
Cipolli
M
M
D000293:Adolescent; D002448:Cell Adhesion; D002609:Chediak-Higashi Syndrome / Q000503:physiopathology; D002630:Chemotactic Factors / Q000172:deficiency; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D002925:Ciliary Motility Disorders / Q000503:physiopathology; D006402:Hematologic Diseases / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009503:Neutropenia / Q000503:physiopathology; D009504:Neutrophils
D002630:Chemotactic Factors
La chemiotassi del neutrofilo. II. Implicazioni cliniche e cenni di terapia in età pediatrica.