Parasitological serendipity: from Schistocephalus to Echinococcus.
Attention is drawn to the situation nowadays, whereby workers are encouraged to undertake research which appears useful or of economic importance, although the History of Science indicates that many major discoveries have been the result of 'serendipity'--'the chance observation falling on the receptive eye'. Some of the more important examples in Medicine and Parasitology are reviewed. The author then relates how he was given a stickleback infected with the plerocercoid of Schistocephalus solidus, an episode which eventually led to the successful in vitro culture of the adult of this species. Attention is also drawn to the largely unrecognized work of the Danish Veterinarian, P. C. Abildgaard, who in 1789 demonstrated that this species completed its life cycle in a bird, thus establishing, for the first time, the transmission of a parasite from one host to another. The in vitro culture of S. solidus led to the development of successful in vitro techniques for Ligula intestinalis and for Echinococcus granulosus and E. multilocularis. The observation that E. granulosus of horse origin failed to grow in vitro led eventually to the concept of physiological 'strains' of E. granulosus, now a subject of much international research.
Smyth
J D
JD
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, U.K.
D000818:Animals; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D010274:Parasitology / Q000266:history*; D012106:Research / Q000266:history*