Imaging of the heart using metaiodobenzylguanidine.
Catecholamines have profound influences on cardiac function. Mechanisms relating abnormalities in sympathetic innervation to myocardial dysfunction are poorly understood, however. Recent studies have demonstrated the feasibility of noninvasively imaging the sympathetic nerves of the heart using radiolabeled MIBG. This article examines some of the experimental evidence to support the neuronal localization of MIBG. In addition, the early clinical experience is reviewed.
Dae
M W
MW
Department of Radiology, University of California, San Francisco 94143-0252.
Botvinick
E H
EH
D019797:3-Iodobenzylguanidine; D006321:Heart / Q000294:innervation*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine