An oxygen dependence in chromium mutagenesis.
Evidence is provided that mutagenicity in Salmonella by a chromium(VI) salt and a chromium(III) compound has a differential dependence on the presence of oxygen. The mutagenic chromium(III) compound, cis-dichlorobis(2,2'-bipyridyl)chromium(III), reverted Salmonella strains, TA102 and TA2638, only under aerobic conditions. Potassium dichromate (chromium VI) required the presence of oxygen to revert the Salmonella strain TA102 but induced a moderate reversion frequency in TA2638 under anaerobic conditions. The data also support a role for oxygen radicals in chromium-mediated mutagenesis and suggests at least two pathways by which chromium compounds can induce mutations.
Department of Biochemistry, Montana State University, Bozeman 59715.
K D
KD
Sugden
R B
RB
Burris
S J
SJ
Rogers
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D002857:Chromium / Q000494:pharmacology / Q000633:toxicity*; D008769:Methylnitronitrosoguanidine; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology / Q000633:toxicity; D010100:Oxygen / Q000494:pharmacology*; D011192:Potassium Dichromate / Q000494:pharmacology / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity
D009153:Mutagens; D009942:Organometallic Compounds; D002857:Chromium; D008769:Methylnitronitrosoguanidine; C064833:dichlorobis(2,2'-bipyridyl)chromium(III); D015082:2,2'-Dipyridyl; D010100:Oxygen; D011192:Potassium Dichromate