In vitro antimalarial activity of Coutarea latiflora and Exostema caribaeum extracts on Plasmodium falciparum.
The medicinal plants, Coutarea latiflora Sesse & Moc. ex. DC. (Hintonia latiflora Bullock) (Rubiaceae) and Exostema caribaeum (Jacq.) Roem. et Schult. (Rubiaceae) were examined for antimalarial properties. Among different crude solvent extracts of the stem bark, the hydrolysed ethyl acetate extracts were shown to have the most potent in vitro antimalarial activity. One compound isolated from the ether extract from Exostema caribaeum showed only moderate activity.
Noster
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Lehrstuhl für Pharmakognosie, Universität Hamburg, Federal Republic of Germany.
Kraus
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L
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000633:toxicity; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects
C064384:4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxidocoumarin; D000962:Antimalarials; D003374:Coumarins; D010936:Plant Extracts