[Sweet's syndrome after T-lymphoblastic lymphoma and before the manifestation of a secondary acute myeloid leukemia].
Thirty-two months after the diagnosis and treatment of a T-lymphoblastic lymphoma with bone marrow involvement had been made in a 30-year-old patient, he developed fever up to 40 degrees C during maintenance treatment with methotrexate and 6-mercaptopurine. Later there were tender, blue-red skin eruptions, leukocytopenia (1.4 x 10(9)/l) and thrombocytopenia (29 x 10(9)/l). Histological examination of a skin biopsy revealed acute febrile neutrophilic dermatosis (Sweet's syndrome). Bone marrow biopsy revealed hyperplastic myelopoiesis. There was no evidence for acute myeloid leukaemia or lymphoma recurrence. After the maintenance treatment had been discontinued, treatment with methylprednisolone, 60 mg, was begun. The signs of Sweet's syndrome regressed, but thrombocytopenia and mild leukocytopenia remained. Six months later it was found by morphological and immunological tests that he had acute myeloid leukaemia without any chromosomal abnormalities. There was still no evidence for a recurrent T-lymphoblastic lymphoma.
II. Medizinische Klinik und Poliklinik, Universität Kiel.
J
J
Ollech-Chwoyka
A
A
Krüger
E
E
Christophers
H
H
Löffler
D000328:Adult; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications*; D013921:Thrombocytopenia / Q000150:complications
Sweet-Syndrom nach T-lymphoblastischem Lymphom und vor der Manifestation einer sekundären akuten myeloischen Leukämie.