Remnant model of renal failure in the dog: avoidance of second surgery by chemical nephrectomy.
Experimental chronic renal failure in the dog is usually studied by a two-step surgical procedure. However, it is becoming increasingly difficult, due to animal welfare concerns, to get permission for such procedures in Canada. We describe a method for obviating the need for second surgery by injecting absolute alcohol into a renal artery, which leads to immediate functional nephrectomy.
Fine
A
A
Faculty of Medicine, University of Manitoba, Winnipeg.
Jones
D
D
Kaushal
G
G
LeGal
Y
Y
Sharma
G
G
D000827:Animal Welfare; D000818:Animals; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D000431:Ethanol; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000503:physiopathology; D007700:Kinetics; D008026:Ligation; D008657:Metabolic Clearance Rate; D009392:Nephrectomy; D012077:Renal Artery / Q000601:surgery
D000431:Ethanol; D003404:Creatinine