[Immunologic aging. Effect of denutrition].
Ageing leads to decrease of immune functions. The T lymphocyte is more susceptible to ageing than the B lymphocyte for which in vitro functions are almost preserved. All functions of cell mediated immunity are decreased in elderly. T lymphocyte are less mature, present decreased T helper and T suppressive functions, decreased T proliferative ability responses to stimuli and lower interleukin synthesis. T dependent antibody responses are also decreased: primary responses are diminished and secondary responses less specific. Nevertheless in healthy elderly such immune deficiency remains minor. Underdiminution whatever it concerns (mostly proteins but also vitamin or trace elements) also leads to immunodeficiency. When it occurs in aged individuals, undernutrition rapidly induces a profound immunodeficit. Prevention of prompt treatment of all undernutrition states is a major concern in geriatrics.
Médecine Interne Gériatrique, Hôpital Charles-Foix, Ivry/Seine.
B M
BM
Lesourd
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology* / Q000378:metabolism; D000917:Antibody Formation; D006801:Humans; D007154:Immune System Diseases / Q000378:metabolism; D009748:Nutrition Disorders / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes
Le viellissement immunologique. Influence de la dénutrition.