[Hypercalcemia associated with blast crisis of chronic myeloid leukemia].
We describe a patient with CML who developed hypercalcemia in his course of blast crisis. A 25-years-old man was diagnosed as CML with priapism in April 1985, and controlled with BHAC-DVP, VMP, busulfan therapy. In December 1987, he readmitted to our hospital with abdominal pain. Investigations at that time showed: white blood cell count 11600/microliters (blast cells 9%); hemoglobin 8.4 g/microliters; platelets 19.0 X 10(4)/microliters; serum calcium 13.2 mg/dl; BUN 44 mg/dl; creatinine 2.7 mg/dl. Treatment with predonine, 6-MP and vincristine was begun. But serum calcium level rose gradually up to 16.5 mg/dl. So we tried middle dose Ara-c therapy, serum calcium decreased to 6.8 mg/dl. At once he was in a chronic phase, but he relapsed and died of heart failure. Necropsy showed extensive leukemic blast-cell infiltration of the bone marrow, liver, spleen, lung, and kidney. The cause of hypercalcemia in our case was suspected of local osteolytic hypercalcemia, because multiple bone destruction was found.
First Department of Internal Medicine, Yokohama City University School of Medicine.
T
T
Murata
S
S
Motomura
H
H
Harano
H
H
Kanamori
H
H
Miyasita
K
K
Ogawa
T
T
Ookubo
D000328:Adult; D001752:Blast Crisis / Q000473:pathology*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000473:pathology*; D008297:Male; D010014:Osteolysis / Q000209:etiology