Dialyzable factors from uremic serum increase 125I-fibrinogen binding by normal blood platelets.
The influence of uremic serum on 125I-fibrinogen binding by normal blood platelets after induction with adenosine diphosphate was evaluated. The study was performed on 12 hemodialyzed uremic patients. The control group included 12 healthy subjects. It has been demonstrated that the uremic serum from the patients before hemodialysis significantly augmented fibrinogen binding by normal blood platelets (33.8 +/- 11.8%) in comparison with control subjects (14.4 +/- 8.9%). After hemodialysis, fibrinogen binding was comparable with the control group (14.9 +/- 10.1%). Uremic toxins removable during hemodialysis are probably responsible for the potentiation of 125I-fibrinogen binding by platelets.
Department of Hematology, Academy of Medicine, Poznań, Poland.
M
M
Komarnicki
D
D
Krupa
M
M
Kaźmierczak
D
D
Drobnik
M
M
Zozulińska
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D011865:Radioisotope Dilution Technique; D012016:Reference Values; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood
D007457:Iodine Radioisotopes; D010980:Platelet Membrane Glycoproteins; D005340:Fibrinogen