Genetic linkage and complex diseases, with special reference to psychiatric disorders.
Recent linkage findings for psychiatric disorders, in particular schizophrenia, manic-depression, and Alzheimer disease, have raised a number of important conceptual issues regarding the genetic etiology of these diseases, as well as the appropriate interpretation of linkage results in studying complex diseases. Perspectives on mode of inheritance, genetic heterogeneity, and phenotypic variation are given.
Risch
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Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510.
D000483:Alleles; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics