High-dose growth hormone treatment of non-growth hormone-deficient children: preliminary results after 2 years.
The growth response to high-dose growth hormone (GH) therapy was investigated in 10 short, prepubertal, slowly-growing children. Two years treatment with recombinant human GH at a dose of 0.3 IU/kg daily 7 days per week resulted in a mean height increase of 19.5 cm (range 17-23 cm). There was a slight but not significant acceleration of bone age maturation. The treatment also induced a sustained increase in insulin secretion without detectable changes in glucose tolerance.
Hôpital St Vincent de Paul, Paris, France.
P F
PF
Bougnères
D001786:Blood Glucose / Q000378:metabolism; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D011994:Recombinant Proteins
D001786:Blood Glucose; D007328:Insulin; D011994:Recombinant Proteins; D013006:Growth Hormone