Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals.
Vanden Bossche
H
H
Janssen Research Foundation, Beerse, Belgium.
Marichal
P
P
Gorrens
J
J
Bellens
D
D
Moereels
H
H
Janssen
P A
PA
D000935:Antifungal Agents / Q000378:metabolism*; D001393:Azoles / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D005658:Fungi / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D009154:Mutation; D010088:Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D058886:Sterol 14-Demethylase
D000935:Antifungal Agents; D001393:Azoles; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D058886:Sterol 14-Demethylase