Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites.
Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.
Schaeffer
J M
JM
Department of Biochemical Parasitology, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
Frazier
E G
EG
Bergstrom
A R
AR
Williamson
J M
JM
Liesch
J M
JM
Goetz
M A
MA
D000818:Animals; D000969:Antinematodal Agents / Q000378:metabolism* / Q000494:pharmacology; D016227:Benzoquinones / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D001667:Binding, Competitive; D002107:Caenorhabditis / Q000187:drug effects*; D007559:Ivermectin / Q000378:metabolism*; D015394:Molecular Structure; D011955:Receptors, Drug / Q000378:metabolism*
D000969:Antinematodal Agents; D016227:Benzoquinones; D011955:Receptors, Drug; C066134:cochlioquinone A; D007559:Ivermectin