Antenatal origin of neurologic damage in newborn infants. II. Multiple gestations.
Necrosis of the cerebral white matter may be identified in living infants with echoencephalography. Echoencephalographic studies were performed in 89 twins and 12 triplets at less than 36 weeks of gestation to determine the incidence and complications associated with antenatal necrosis of the cerebral white matter. Antenatal necrosis of the cerebral white matter was identified when brain atrophy or cavities in the white matter were present by day 3 of life. Fourteen infants (13.8%) were considered to have antenatal necrosis of the cerebral white matter. The incidence of antenatal necrosis of the cerebral white matter was higher in monochorionic than in dichorionic infants (30% vs 3.3%; p less than 0.001). Univariate analysis showed that antenatal necrosis of the cerebral white matter was significantly associated with polyhydramnios, intrauterine fetal death of the cotwin, hydrops, multiple placental vascular connections, and placental artery-to-artery, vein-to-vein, and artery-to-vein anastomosis. Logistic regression analysis showed that antenatal necrosis of the cerebral white matter was predicted by the presence of either artery-to-artery or vein-to-vein anastomosis and by intrauterine fetal death of a cotwin. Vein-to-vein anastomosis had the strongest association, because 89% of seven infants with vein-to-vein anastomosis demonstrated antenatal necrosis of the cerebral white matter (p = 0.003). Monochorionic multiple gestations frequently are complicated by antenatal necrosis of the cerebral white matter. Multiple vascular connections with vein-to-vein anastomosis appear as the most important associated factor for antenatal necrosis of the cerebral white matter in this population.
Bejar
R
R
Department of Pediatrics, University of California, San Diego 92103-998.
Vigliocco
G
G
Gramajo
H
H
Solana
C
C
Benirschke
K
K
Berry
C
C
Coen
R
R
Resnik
R
R
D000704:Analysis of Variance; D001163:Arteriovenous Anastomosis; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000151:congenital* / Q000209:etiology; D004453:Echoencephalography; D005260:Female; D005313:Fetal Death / Q000150:complications; D005330:Fetofetal Transfusion / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D009336:Necrosis; D009417:Nerve Tissue / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000473:pathology; D006831:Polyhydramnios / Q000150:complications; D011247:Pregnancy; D011272:Pregnancy, Multiple