[The danger of hepatitis B virus infection from transfusions of plasma in which the HBs-antigen was detected retrospectively by highly sensitive methods].
The prospective dynamic laboratory and clinical study of premature children was carried out: 55 children who received plasma transfusion during the first weeks of their life and were retrospectively (i. e. after plasma transfusion) found to have HBsAg detected by the passive hemagglutination (PHA) test, the enzyme immunoassay (EIA) and the radioimmunoassay (RIA) and 127 children who received the transfusion of plasma found to be HBsAg-negative according to the results of EIA and RIA. As revealed in this study, the risk of hepatitis B virus infection in such children after the transfusion of plasma containing HBsAg at low concentrations, determined only in the PHA test or in EIA and RIA, was, respectively, 7.5 and 6.3 times greater than in children receiving plasma found to be HBsAg-negative according to the results of EIA and RIA. The results of this investigation showed the tendency towards a decrease not only in the total contamination of plasma recipients with hepatitis B virus, but also in morbidity rate in icteric forms of acute posttransfusion hepatitis B, depending on the concentration of HBsAg in plasma used for transfusion.
Sychev
A V
AV
Shakhgil'dian
I V
IV
Mikhaĭlov
M I
MI
Zubov
S V
SV
Vlasikhina
E M
EM
Braginskiĭ
D M
DM
Kozlova
T P
TP
Golosova
T V
TV
D003378:Counterimmunoelectrophoresis; D004306:Dose-Response Relationship, Immunologic; D006386:Hemagglutination Tests; D006509:Hepatitis B / Q000453:epidemiology* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007234:Infant, Premature; D010949:Plasma / Q000276:immunology*; D011446:Prospective Studies; D011863:Radioimmunoassay; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction
D006514:Hepatitis B Surface Antigens
Opasnost' zarazheniia virusom gepatitia B pri perelivaniiakh plazmy, v kotoroĭ retrospektivno vysokochuvstvitel'nymi metodami vyiavlen HBs-antigen.