[Left ventricle diastolic function in hypertensive patients and responses to captopril].
The LV diastolic function of 37 cases with primary hypertension were studied by measuring the diastolic filling blood stream at mitral orifice using pulsed Doppler echocardiography. 30/37 (81%) patients were found to have impaired LV diastolic function as compared with 30 normals of a group at similar age. After 4 weeks of oral captopril treatment in 20/37 patients, BP dropped in 19/20; LV diastolic function improved in 75-80%; left ventricular mass also regressed in 16/20 captopril treated patients (210 +/- 62 vs 171 +/- 46 g, P less than 0.01). It showed that captopril is not only effective in lowering blood pressure but also in improving the impaired LV diastolic function.
Luo
H
H
Anhui Provincial Hospital, Hefei.
D000328:Adult; D000368:Aged; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D003971:Diastole / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
D002216:Captopril