HLA antigens in lichen sclerosus et atrophicus.
Several reports have found conflicting data regarding the association between lichen sclerosus et atrophicus (LSA) and HLA types. Association with HLA-A31 and -B40 has been noted, whereas another report found no correlation. We are the first to specifically examine HLA types in white patients in the United States. We have found a significant association between LSA and HLA-A29 and -B44 individually and an even stronger association with the combination of A29 and B44. A review of previous LSA-HLA studies, as well as several reports of HLA typing in familial LSA, is discussed, with consideration given to possible reasons for the discrepancies among the various studies.
Purcell
K G
KG
Division of Dermatology, University of Louisville, Ky.
Spencer
L V
LV
Simpson
P M
PM
Helman
S W
SW
Oldfather
J W
JW
Fowler
J F
JF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D059947:HLA-B40 Antigen; D059948:HLA-B44 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012598:Sclerosis; D012871:Skin Diseases / Q000276:immunology*
D006680:HLA Antigens; D015234:HLA-A Antigens; C035524:HLA-A29 antigen; C069527:HLA-A31 antigen; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; D059948:HLA-B44 Antigen