Effects of unilateral intrahippocampal injection of MK-801 upon local cerebral glucose utilisation in conscious rats.
The effects of unilateral intrahippocampal injections of the non-competitive NMDA receptor antagonist, MK-801, on local cerebral glucose utilisation have been examined in conscious rats using [14C]2-deoxyglucose autoradiography. The intrahippocampal injection of MK-801 (10 nmol) induced significant marked increases in glucose use in the ipsilateral hippocampus molecular layer and dentate gyrus (by 31 and 44%, respectively). Function-related glucose use in brain regions with known neuronal connections with the site of drug administration (e.g. entorhinal cortex, septal nucleus, mamillary body) was minimally altered after intrahippocampal MK-801 administration. Blockade of hippocampal NMDA receptors does not appear to modify activity, as reflected in local glucose utilisation, in hippocampal afferent and efferent circuits in conscious rats.
Kurumaji
A
A
Wellcome Surgical Institute, University of Glasgow, U.K.
McCulloch
J
J
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003986:Dibenzocycloheptenes / Q000008:administration & dosage / Q000494:pharmacology*; D016291:Dizocilpine Maleate; D007839:Functional Laterality; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003986:Dibenzocycloheptenes; D016291:Dizocilpine Maleate; D003847:Deoxyglucose