Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder?
It seems unlikely that a solitary disturbance in serotonin function can fully account for the pathophysiology of obsessive compulsive disorder. The authors propose that some forms of obsessive compulsive disorder, e.g., obsessive compulsive disorder with a history of Tourette's syndrome, may involve a relative or absolute derangement in both brain serotoninergic and dopaminergic systems. A role for dopamine in the pathophysiology of obsessive compulsive disorder is supported by a review of the preclinical and clinical evidence. Additional studies are needed to more directly evaluate dopamine function in patients with obsessive compulsive disorder.
Goodman
W K
WK
Yale University, School of Medicine, Department of Psychiatry, New Haven, CT.
McDougle
C J
CJ
Price
L H
LH
Riddle
M A
MA
Pauls
D L
DL
Leckman
J F
JF
D004298:Dopamine / Q000502:physiology*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology; D005879:Tourette Syndrome / Q000503:physiopathology
D012701:Serotonin; D004298:Dopamine