The paradoxical stress response: a possible common basis for depression and other conditions.
This paper assumes that there are two types of stress-related pathology, the orthodox and the paradoxical, both depending on a positive feedback mechanism controlling the stress-related sympathetic discharge. The paradoxical stress response is speculated to be the common basis for a group of conditions, including depression, panic attacks, obesity, sexual deviations, alcoholism, and drug addiction. Evidence is provided that trazodone inhibits the stress-related sympathetic discharge. This would provide a rationale for its use not only in depression, but also in other conditions depending on an exaggeration of the orthodox or paradoxical stress response.
Silvestrini
B
B
Institute of Pharmacology and Pharmacognosy, University of Rome, La Sapienza, Italy.
D000818:Animals; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D013312:Stress, Physiological / Q000150:complications*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014196:Trazodone / Q000627:therapeutic use
D014196:Trazodone