Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli.
Vanillin and its isomer o-vanillin have an effect on the adaptive and SOS responses, as well as mutagenesis, induced in Escherichia coli by N-methyl-N-nitrosourea (MNU) and UV irradiation, potentiating in some cases and suppressing in others. o-Vanillin markedly inhibited the MNU-induced adaptive response, while both vanillins potentiated the UV-induced SOS response. These phenomena appear to be responsible for the comutagenic or antimutagenic role of these chemicals in MNU and UV mutagenesis.
Takahashi
K
K
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Sekiguchi
M
M
Kawazoe
Y
Y
D001547:Benzaldehydes / Q000494:pharmacology*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics*; D015870:Gene Expression; D005798:Genes, Bacterial; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D008770:Methylnitrosourea / Q000494:pharmacology; D009154:Mutation; D010957:Plasmids; D013014:SOS Response, Genetics; D014466:Ultraviolet Rays
D001547:Benzaldehydes; D004269:DNA, Bacterial; C060843:2-vanillin; D006147:Guanine; D008770:Methylnitrosourea; C008449:O-(6)-methylguanine; C100058:vanillin