Does heparin improve survival in experimental porcine gram-negative septic shock?
To evaluate the effects of heparin on gram-negative septic shock, immature piglets were subjected to fecal Escherichia coli peritonitis. One group of animals received a continuous infusion of heparin 25 units/kg/hr, while the control animals were given an equivalent volume of lactated Ringer's solution. Heparin-treated animals (n = 5) had a mean survival time (+/- SEM) of 18.8 +/- 2.2 hr vs. 11.9 +/- 2.8 (P less than 0.05) in controls (n = 5). Animals receiving heparin tended to have improved hemodynamic profiles and less leukopenia than controls.
Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.
M P
MP
Griffin
D C
DC
Gore
J B
JB
Zwischenberger
T E
TE
Lobe
M
M
Hall
D L
DL
Traber
D N
DN
Herndon
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004927:Escherichia coli Infections; D006493:Heparin / Q000627:therapeutic use*; D007958:Leukocyte Count; D010538:Peritonitis / Q000150:complications*; D011651:Pulmonary Artery / Q000503:physiopathology; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013552:Swine; D014655:Vascular Resistance; D014914:Whole Blood Coagulation Time
D006493:Heparin