[Compensation in diabetes and serum insulin levels in type I diabetics during insulin pump therapy and after changing to treatment with a combination of short- and long-acting insulin].
Twenty-one type diabetics previously treated in the conventional way with insulin with unsatisfactory results were admitted to hospital. The blood sugar level, serum insulin and non-esterified fatty acids in serum (NEFA) were assessed from 6 a.m. to 2 a.m. during treatment with an insulin pump and after changing the patients to insulins with varying length of action. Patients in the following groups were followed up separately: a) patients with antibodies against insulin treated either by two (n = 4) or three (n = 12) injections; b) patients with antibodies (n = 16) and without antibodies (n = 5), regardless of the number of insulin injections. Changes from the insulin pump regime implied an increased insulin requirement, (significant only in group b) and deteriorated compensation of diabetes which was more markedly manifested when evaluated by index M according to Schlichkrull with the exception of the group without antibodies, where M remained despite the increase in the range of satisfactory compensation. The NEFA profile behaved in a reversed manner, as compared with the serum insulin level. The results confirm the greater success of insulin pump treatment when attempting to maintain the blood sugar level as close as possible to normal values. From the analysis of the blood sugar and serum insulin profile recommendations for the tactics of treatment are derived, when the use of an insulin pump is not possible.
III. interní katedra fakulty vseobecného lékarství Univerzity Karlovy, Praha.
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J
Páv
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Svacina
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J
Srámková
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J
Hilgertová
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood*; D007332:Insulin Infusion Systems; D008875:Middle Aged
D005230:Fatty Acids, Nonesterified; D007328:Insulin
Kompenzace cukrovky a hladiny inzulínu v séru u diabetiků I. typu pri lécbĕ inzulínovou pumpou a po prevedení na lécbu kombinací inzulínů s krátkým a prodlouzeným úcinkem.