Effect of intermittent positive pressure ventilation on diastolic ventricular filling patterns in premature infants.
Eleven preterm newborn infants had a Doppler echocardiographic examination of their ventricular filling patterns during intermittent positive pressure ventilation. Peak velocity during early ventricular filling (VE) and during atrial systole (VA) and diastolic velocity-time integral of early (IE) and late (IA) ventricular filling caused by atrial contraction were measured. The ratios of VE/VA and IE/IA were also calculated. Diastolic peak velocities, as well as the diastolic velocity-time integral of early and late ventricular filling measured through the mitral valve were significantly higher during inspiration. The peak of the wave representing the velocity during atrial systole (A) was always higher than the peak of the wave representing the velocity of early ventricular filling (E). As a result, the ratio of these two variables (E/A) was always less than 1, showing no significant variation from inspiration to expiration. The flow patterns into the right ventricle were the opposite of those observed through the mitral valve. During inspiration, a significant decrease (p less than 0.001) in peak and time integral velocities of both the early ventricular filling and atrial systole waves was observed. Heart rate did not vary with respiration. It is concluded that during positive pressure ventilation, inspiration decreases right ventricular filling and enhances left ventricular filling. Opposite changes are recorded during expiration. Early and late phases of diastolic filling are equally affected. These changes are different from those observed during spontaneous breathing and should be taken into account in the assessment of diastolic ventricular function in preterm infants requiring assisted ventilation.
Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Quebec, Canada.
E
E
Maroto
J C
JC
Fouron
G
G
Teyssier
H
H
Bard
N H
NH
van Doesburg
D
D
Cartwright
D001783:Blood Flow Velocity; D003971:Diastole; D004452:Echocardiography; D006801:Humans; D007231:Infant, Newborn; D007385:Intermittent Positive-Pressure Ventilation; D008943:Mitral Valve / Q000502:physiology; D011175:Positive-Pressure Respiration; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D013318:Stroke Volume / Q000502:physiology*; D014261:Tricuspid Valve / Q000502:physiology