The influence of ketanserin on blood pressure and heart rate during induction of anesthesia: a randomized double blind controlled evaluation.
Increases in blood pressure and heart rate often seen with laryngoscopy and endotracheal intubation during induction of anesthesia can be dangerous for many patients. In twenty five patients pretreated with ketanserin, a new antihypertensive agent, changes in blood pressure and heart rate were compared with the hemodynamic parameters of twenty untreated patients. Ketanserin 10 mg intravenously was administered prior to induction of anesthesia. Ten mg i.v. ketanserin will not prevent increases in arterial pressure; however the increases in diastolic and mean arterial pressure are significantly lower than these increases in untreated patients.
Vanacker
B
B
Department of Anesthesiology, University Hospitals, Katholieke Universiteit Leuven, Belgium.
Van Aken
H
H
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003971:Diastole / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013599:Systole / Q000187:drug effects
D000959:Antihypertensive Agents; D007650:Ketanserin