Acute central nervous system symptoms caused by ibuprofen in connective tissue disease.
We describe 2 cases of acute encephalopathy in patients with connective tissue disease caused by small doses of ibuprofen. In addition to aseptic meningitis, both patients had altered mental status and focal neurologic signs, ophthalmoplegia in one and hemiparesis in the other. The spectrum of neurologic manifestations of ibuprofen hypersensitivity is reviewed.
Agus
B
B
Department of Medicine, NYU School of Medicine, NY.
Nelson
J
J
Kramer
N
N
Mahal
S S
SS
Rosenstein
E D
ED
D000208:Acute Disease; D000328:Adult; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D003240:Connective Tissue Diseases / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006429:Hemiplegia / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male; D008582:Meningitis, Aseptic / Q000139:chemically induced; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000139:chemically induced; D011928:Raynaud Disease / Q000188:drug therapy
D007052:Ibuprofen