Application of new two-sample tests to data from a randomized placebo-controlled heart-failure trial.
In a randomized placebo-controlled double-blind trial of 230 congestive heart failure patients, four treatments were evaluated for efficacy, with exercise tolerance time (ETT) as the primary outcome. Various two-sample tests were applied to the analysis of ETT data. It is shown in this paper that the conventional two-sample tests (t and rank-sum) are insensitive to situations where the effect of the experimental therapy is not consistent across a patient population. Tests recommended by O'Brien are more appropriate for these data. It is also shown that the application of the O'Brien tests led to the identification of sub-groups where the observed effect of the experimental therapy was most pronounced.
Sterling Research Group, Malvern, Pennsylvania 19355.
P K
PK
Tandon
H
H
Stander
R P
RP
Schwarz
D000328:Adult; D003627:Data Interpretation, Statistical; D004077:Digoxin / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020105:Milrinone; D011728:Pyridones / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013223:Statistics as Topic / Q000379:methods*; D014665:Vasodilator Agents / Q000627:therapeutic use
D011728:Pyridones; D014665:Vasodilator Agents; D004077:Digoxin; D020105:Milrinone