[Inhibitory effect of liuwei dihuang decoction on induced mutation and spontaneous tumor].
Anti-mutagenic activity was evaluated with micronuclear test. It appeared to be same between the result of mice treated with 10 g/kg Liuwei Dihuang decoction (LWDHd) for 3 days and that with 34.5 g/kg for 10 days. All the permillages of micronuclear appearance of treated groups were less than that of controls. The intercept (A) value of dose-effect curve were 12.7 and 9.4 as treated with cyclophosphamide (Cy) alone, but 1.2 and 3.2 as orally administered with LWDHd before injecting Cy. It showed that LWDHd could inhibite mutagenic activity of Cy. The affection of LWDHd on spontaneous tumorigenesis was observed in LACA mice. The tumor incidence rate was 9.0% in the control mice observed for 60 weeks, but 5.0% in the animal feeding LWDHd in food. The tumor incidence rate of big dose group was 1.0% and the difference was significant between it and that of the control (P less than 0.01).
Institute of Chinese Materia Medica, China Academy of TCM, Beijing.
L
L
Zhao
S
S
Yan
T
T
Jiang
D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009154:Mutation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control
D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide