Tisseel, a two component fibrin tissue sealant system: report of a trial involving anticoagulated dental patients.
There have been attempts since the early years of this century to produce a biocompatible, biodegradable tissue glue to aid in hemostasis and lessen the need for conventional sutures. In the early 1970s, Matras et al developed a glue to anastomose the severed ends of peripheral nerves, and which was the precursor of the product tested in this trial. Since that time, the product has gained wide acceptance in Europe, with applications in microvascular anastomosis, hemostasis of soft tissue defects, bone sealing and dural sealing.
Faculty of Dentistry, University of Alberta, Edmonton.
G W
GW
Raborn
F I
FI
Hohn
M G
MG
Grace
B K
BK
Arora
D000925:Anticoagulants / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006489:Hemostatic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000517:prevention & control*; D013515:Surgery, Oral / Q000379:methods
D000925:Anticoagulants; D015718:Fibrin Tissue Adhesive