Immunoregulatory activity in human decidua.
The immunoregulatory factor(s) that suppresses normal human peripheral blood mononuclear cells (PBM) function was extracted from the decidua of pregnant women (8-13 weeks). Compared with extracts from the proliferative endometrium, the decidual extracts from fresh surgical specimens markedly inhibited 3H-thymidine incorporation by PBM in response to T-cell mitogens. The majority of the lymphocyte-inhibitory activity was found to be associated with a material of large molecular weight in the decidua, as estimated by Sephadex G-200 filtration. Immunoelectrophoretic analysis followed by Sepharose 4B-anti-human IgG affinity chromatography of the fraction having the inhibitory activity revealed the causative factor to be most likely IgG or a substance copurified with IgG. The results are discussed with respect to a possible role of IgG in a localized non-specific suppressor mechanism in the decidua preventing maternal immunologic attack on the fetal allograft.
Department of Obstetrics and Gynecology, Kumamoto University Medical School.
Y
Y
Kitano
S
S
Fujisaki
N
N
Nakamura
H
H
Okamura
D000328:Adult; D003656:Decidua / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D008970:Molecular Weight; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013601:T-Lymphocytes / Q000276:immunology*; D014020:Tissue Extracts
D007074:Immunoglobulin G; D008934:Mitogens; D014020:Tissue Extracts