Modulation of hippocampal primed burst potentiation by anesthesia.
This study demonstrates that the anesthetics urethane and pentobarbital differentially affect a low threshold form of long-lasting synaptic plasticity, termed primed burst (PB) potentiation, in the CA1 area of rat hippocampus. PB potentiation was generated by the delivery of a 5-pulse patterned stimulus train, consisting of one priming pulse followed 170 ms later by a burst of 4 pulses at 200 Hz. PB potentiation could not be reliably generated in urethane-anesthetized rats unless stimulus currents were raised to 150% of baseline levels during the stimulus train. In pentobarbital-anesthetized rats, PB potentiation could always be evoked at baseline stimulus intensities. Differences between the anesthetics which could contribute to their varying effects upon PB potentiation are discussed.
Medical Research Service, Veterans Administration Medical Center, Denver, CO 80220.
D A
DA
Engstrom
M C
MC
Bennett
K E
KE
Stevens
R L
RL
Wilson
D M
DM
Diamond
M
M
Fleshner
G M
GM
Rose
D000200:Action Potentials / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane / Q000494:pharmacology*
D014520:Urethane; D010424:Pentobarbital; D003345:Corticosterone