[Radio-oncological treatment possibilities in local recurrence of rectal carcinoma. An interdisciplinary comparison].
Local recurrences of rectal carcinomas are frequently associated with a considerable morbidity and a dismal prognosis. Surgical resection leads to long term tumor control in about 30 to 40%, but surgery can be offered to only 10 to 30% of the patients. Cytotoxic chemotherapy is able to induce local responses in 15 to 40% of the cases--similar figures as achieved by radiation therapy alone. A pilot study is presented using radiation therapy combined with the sensitizing agent razoxane (ICRF 159). There was an objective response rate of 62% and the median survival rose to 24 months (13 months with radiation therapy alone). These data compare almost to results seen in surgical series. However, they need confirmation.
Abteilung für Radioonkologie, des Landeskrankenhauses Feldkirch.
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy*; D010879:Piperazines / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D011929:Razoxane / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis
D010879:Piperazines; D011838:Radiation-Sensitizing Agents; D011929:Razoxane
Radioonkologische Behandlungschancen beim Lokalrezidiv des Rektumkarzinoms. Ein interdisziplinärer Vergleich.