Sister chromatid exchange and chromosome aberrations induced by curcumin and tartrazine on mammalian cells in vivo.
Sister chromatid exchanges (SCEs) and chromosomal aberrations induced by curcumin (a natural dye) and tartrazine (a synthetic dye) were studied on bone marrow cells of mice and rats following acute and chronic exposure via the diet. Except for two low concentrations in the curcumin and one low concentration in the tartrazine treated series a significant increase in SCEs was observed in all the concentrations of the two dyes tested. Except for two high concentrations during the 9 months treatment no significant increase in chromosomal aberrations was observed in the curcumin treated series, whereas tartrazine showed a significant increase in chromosomal aberrations in some of the higher concentrations in all the series tested. The results indicate that tartrazine is more clastogenic than curcumin.
Giri
A K
AK
College of Pharmacy, University of Michigan, Ann Arbor 48109.
Das
S K
SK
Talukder
G
G
Sharma
A
A
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013645:Tartrazine / Q000494:pharmacology*
D013645:Tartrazine; D003474:Curcumin