Intravenous glycerol infusions: effect on free fatty acid metabolism.
The plasma-free fatty acid response to intravenous glycerol infused at 250 and 500 mumol/min was determined in five normal volunteers in the postabsorptive state. There was a drop in free fatty acid concentration in all five subjects (one-way ANOVA, p less than 0.01) after the glycerol infusion with no change in insulin concentration compared to the post-absorptive state. These results suggest that intravenous glycerol infusions decrease free fatty acid concentrations in the post-absorptive state by an insulin-independent mechanism. When pharmacologic nonisotopic glycerol infusions are used to determined lipolytic rate, simultaneous measurement of free fatty acid concentrations should be interpreted with caution.
Surgical Metabolism Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
G R
GR
Pesola
H P
HP
Sauerwein
N A
NA
Vydelingum
G
G
Carlon
M F
MF
Brennan
D000328:Adult; D002405:Catheterization, Central Venous; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000378:metabolism*; D008297:Male
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D005990:Glycerol