Cytokines and Ig switching: evolutionary divergence between mice and humans.
Cytokines exert control over many aspects of immunoglobulin regulation, including isotype switching. But is the same mechanism used in subclass regulation in mice and humans? Robin Callard and Malcolm Turner think not, and here caution against the wholesale application of murine studies to humans.
Callard
R E
RE
Department of Immunology, Institute of Child Health, London, UK.
Turner
M W
MW
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005075:Biological Evolution; D001685:Biological Factors / Q000276:immunology*; D016207:Cytokines; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000235:genetics; D007134:Immunoglobulin Switch Region; D015847:Interleukin-4 / Q000494:pharmacology; D051379:Mice
D001685:Biological Factors; D016207:Cytokines; D007132:Immunoglobulin Isotypes; D015847:Interleukin-4