Chloroquine-resistant Plasmodium falciparum malaria in the Kavango region of Namibia.
The sensitivity to chloroquine of Plasmodium falciparum from the Kavango region of Namibia was determined by a 24-hour test in vitro. Twenty-six isolates were successfully tested, of which 11 were resistant to a low degree, schizogony being inhibited at 8 pmol/well. The results of the Dill-Glazko test for the presence of 4-aminoquinolines in urine indicate that chloroquine is not widely used in the area.
Sharp
B L
BL
Research Institute for Diseases in a Tropical Environment of the South African Medical Research Council, Durban.
Freese
J A
JA
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D009276:Namibia; D010963:Plasmodium falciparum / Q000187:drug effects*
D002738:Chloroquine