Secondary structures of Tetrahymena thermophila rRNA IVS sequence involved in its self-splicing reactions: a new computer analysis.
The secondary structures of Tetrahymena thermophila rRNA IVS sequence involved in the self-splicing reactions, are theoretically investigated with a refined computer method previously proposed, able to select a set of the deepest free energy RNA secondary structures under constraints of model hypotheses and experimental evidences. The secondary structures obtained are characterized by the close proximity of self-reactions sites and account for double mutations experiments, and differential digestion data.
Benedetti
G
G
Department of Chemistry, University of Rome I, Italy.
De Santis
P
P
Morosetti
S
S
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003198:Computer Simulation; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D016337:RNA, Catalytic; D012335:RNA, Ribosomal / Q000235:genetics*; D013768:Tetrahymena / Q000235:genetics*
D016337:RNA, Catalytic; D012335:RNA, Ribosomal