Prenyl proteins in eukaryotic cells: a new type of membrane anchor.
Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.
Glomset
J A
JA
Howard Hughes Medical Institute Laboratory, Department of Medicine, University of Washington, Seattle 98195.
Gelb
M H
MH
Farnsworth
C C
CC
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002477:Cells / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D034882:Lamins; D000072235:Mating Factor; D009687:Nuclear Proteins / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011106:Polyisoprenyl Phosphates / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras)
D034882:Lamins; D009687:Nuclear Proteins; D010455:Peptides; D011106:Polyisoprenyl Phosphates; D011506:Proteins; D011518:Proto-Oncogene Proteins; D000072235:Mating Factor; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)