Drug-induced changes of plasma gastrin concentration.
There is a significant inverse relationship between intragastric acidity and plasma gastrin concentration. All generally available gastric acid antisecretory drugs induce a release of gastrin into the circulation. The more potent the gastric antisecretory dosage regimen or drug, the greater the rise of plasma gastrin concentration. The drug-induced rise of plasma gastrin concentration is of no direct clinical concern, although it may be partly responsible for the phenomenon of tolerance to H2-blockade. Drug-induced hypergastrinemia could stimulate the proliferation of certain cell lines associated with the gastrointestinal tract, for example, the gastric epithelium, ECL cells, or colonic neoplasms.
Pounder
R
R
Academic Division of Clinical Sciences, Royal Free Hospital School of Medicine, London, England.
Smith
J
J
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002169:Campylobacter Infections / Q000188:drug therapy; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000009:adverse effects / Q000097:blood* / Q000187:drug effects*; D005756:Gastritis / Q000188:drug therapy; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D006801:Humans
D005755:Gastrins