Autoimmunity and the pathogenesis of glomerulonephritis.
Self-tolerance is maintained by: thymic influences on developing T cells; peripheral mechanisms that can tolerise post-thymic T cells; and to a variable extent the tolerisation of potentially autoreactive B cells. The presence of autoreactive T cells in normal individuals suggests that mechanisms to control the activity of such cells may be important. Failure of any of these processes may lead to autoimmunity. The relationship between glomerulonephritis and the mechanisms leading to breakdown of self-tolerance remains elusive. An important observation is that autoimmune diseases are strongly associated with particular products of the major histocompatibility complex (MHC). This association may reflect the intimate involvement of the MHC in thymic T cell education. Another explanation is that T cells only recognise antigens presented in the context of MHC molecules. Although there has been progress in identifying the targets recognised by autoantibodies in vasculitis and anti-GBM disease, nothing is known about the T cells involved. Despite our ignorance, therapy aimed specifically at the T cell can be effective. This approach is being supplemented by attempts to engage immunoregulatory mechanisms, such as idiotype-antiidiotype interactions. The hope is that such treatments, or combinations thereof, will allow a more focused suppression of the autoimmune response, in contrast to the non-specific (and therefore potentially dangerous) methods of immunosuppression available at present.
Oliveira
D B
DB
Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.
Peters
D K
DK
D001324:Autoantigens; D015551:Autoimmunity; D002648:Child; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens