Glycogenolytic effect of pancreastatin in the rat.
Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. The peptide was isolated from porcine pancreatic extracts and shows a structural similarity to chromogranin A. The effect of synthetic porcine pancreastatin on blood glucose levels and hepatic glycogen content was investigated in rats in vivo. Pancreastatin (300 pmol/kg) produced a time-dependent decrease in glycogen content of liver and a slight hyperglycemia. Basal plasma insulin and glucagon levels were not modified by pancreastatin. We suggest that pancreastatin could play a biological role in the glucose metabolism through a glycogenolytic effect.
Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Sevilla, Spain.
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V
Sanchez
J R
JR
Calvo
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R
Goberna
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D053379:Chromogranin A; D005934:Glucagon / Q000097:blood / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010187:Pancreatic Hormones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001786:Blood Glucose; D053379:Chromogranin A; D007328:Insulin; D008112:Liver Glycogen; D010187:Pancreatic Hormones; C050836:pancreastatin; D005934:Glucagon