Macrophage lysozyme stimulation by fructose-1-6-diphosphate.
FDP produces an increase of serum lysozyme concentration which may be related to stimulation of the phagocytic activity. Mice macrophages in vitro produce extracellular and intracellular LSZ (lysozyme) and FDP (fructose-1-6-diphosphate) increases this production. Also in vivo FDP stimulates the macrophages intracellular lysozyme production. The toxic activity in vitro and the protection in vivo against Staphylococcus pyogenes after FDP administration can also be related to macrophage stimulation.
Laboratory of Applied Biochemistry, Research Laboratories Biomedica Foscama, Roma.
R
R
Tarsi
N
N
Simonetti
A
A
Retico
L
L
Mulieri
D000818:Animals; D002478:Cells, Cultured; D005635:Fructosediphosphates / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D008297:Male; D051379:Mice; D009113:Muramidase / Q000096:biosynthesis*; D010587:Phagocytosis; D011817:Rabbits; D013203:Staphylococcal Infections / Q000473:pathology; D013210:Staphylococcus / Q000276:immunology
D005635:Fructosediphosphates; D009113:Muramidase; C029063:fructose-1,6-diphosphate