[Complexes of phorbol tumor promoters with protein kinase C].
Based on the literature data, a systematic comparison of relationships between the structures of incomplete and complete phorbol tumor promoters, diacylglycerols and their activities in various biological test-systems was carried out. The specific features of the phorbol esters-protein kinase C complexes responsible for the induction of the first and second stages of the tumor promotion in mouse skin, were established. The type of diacylglycerol binding to protein kinase C which confers to the latter noncarcinogenic properties, was specified.
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OV
Kozhemiakina
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LS
Iaguzhinskiĭ
D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D003043:Cocarcinogenesis; D004075:Diglycerides / Q000378:metabolism / Q000633:toxicity; D051379:Mice; D010703:Phorbol Esters / Q000378:metabolism / Q000633:toxicity*; D011493:Protein Kinase C / Q000378:metabolism*; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced*; D013329:Structure-Activity Relationship
D002273:Carcinogens; D004075:Diglycerides; D010703:Phorbol Esters; D011493:Protein Kinase C
Kompleksy opukholepromotorov forbolovogo riada s proteinkinazoĭ C.