[Anti-cancer effects of sanjie pellets].
In the present paper, the authors applied Sanjie pellet in the anti-cancer study on the animals. The results indicated that in the extracorporeal experiment, stomach perfusion with Sanjie pellet 12.5g/kg daily for 10 successive days, the inhibitory rate for the substantive liver cancer was 84%. For ascites liver carcinoma, it could raise the average rate of prolonging life span to 76%. Lethal dose (LD50) was 25 g/kg. The pathological observations indicated that Sanjie pellet acted directly on the cell membrane and organelle of the liver cancer cells and causing lysis of the cell membrane, dilation of rough surface endoplasmic reticulum, the swelling of mitochondria and disintegration of the liver cancer cells body. The authors concluded that these were the main pharmacological efficacies of Sanjie pellet.
Chinese PLA No. 202 Hospital, Shenyang.
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D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D013607:Tablets; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D013607:Tablets