[The immunomodulating properties of a glucomacropeptide from whey. I. The stimulation of resistance in mice].
The immunomodulating effect on mice of three products glucomacropeptides obtained from whey with different carbohydrate and peptide components has been studied. After the preliminary application of the preparations at several doses the protective effect in infections with Salmonella typhimurium and Klebsiella pneumoniae increases to different extent. At lower doses fraction 3 increases in vitro the mitogen-induced proliferation of the thymus cells. The phagocytosis of the polymorphonuclear cells on the 24th hour after application of the three preparations is activated. The influence of the structurally different fractions on the immunoprotective effect is discussed.
Neĭchev
Kh
Kh
Slavcheva
E
E
Abrashev
I
I
Todorova
P
P
Mitov
I
I
Veselinova
D
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007113:Immunity, Innate / Q000187:drug effects* / Q000276:immunology; D007710:Klebsiella Infections / Q000276:immunology / Q000517:prevention & control; D007711:Klebsiella pneumoniae; D051379:Mice; D008894:Milk Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control; D012486:Salmonella typhimurium; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D000067816:Whey Proteins
D000276:Adjuvants, Immunologic; D008894:Milk Proteins; D000067816:Whey Proteins
Imunomodulirashti svoĭstva na gliukomakropeptid ot surovatka. I. Stimulirane na rezistentnostta pri mishki.