[Metabolic activation of carcinogenic N-nitrosodialkylamines].
Chemical and biological properties of metabolically activated species of carcinogenic N-nitrosodialkylamines are reviewed. alpha-Hydroxy nitrosamines and their derivatives; alpha-acetoxy nitrosamines, alpha-hydroperoxy nitrosamines, alpha-phosphonooxy nitrosamines and alkanediazotates are included. Metabolic deactivation through denitrosation and metabolic activation through beta-oxidation are also mentioned.
Kyoritsu College of Pharmacy, Tokyo, Japan.
M
M
Mochizuki
D000818:Animals; D001419:Bacteria / Q000235:genetics; D001711:Biotransformation; D009154:Mutation; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*
D009602:Nitrosamines