Reversible myopathy due to labetalol.
A severe, generalized myopathy developed in 2 children treated with labetalol. An 11-year-old girl and a 14-year-old boy demonstrated proximal weakness and markedly elevated creatine kinase levels during labetalol therapy. Clinical improvement began immediately when labetalol administration was halted; muscle strength was normal within 2 months. Muscle biopsies were consistent with rhabdomyolysis.
Department of Psychiatry, Tulane University, New Orleans, Louisiana.
J K
JK
Willis
A H
AH
Tilton
J C
JC
Harkin
F G
FG
Boineau
D058186:Acute Kidney Injury / Q000150:complications; D000293:Adolescent; D002648:Child; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications; D016030:Kidney Transplantation; D007741:Labetalol / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D011183:Postoperative Complications / Q000188:drug therapy
D007741:Labetalol