Association of MS Pi phenotype with airway hyperresponsiveness.
Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and alpha 1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.
Allergic Disease Center, Creighton University, Omaha.
R G
RG
Townley
J G
JG
Southard
P
P
Radford
R J
RJ
Hopp
A K
AK
Bewtra
L
L
Ford
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D002648:Child; D006579:Heterozygote; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D010641:Phenotype; D012882:Skin Tests; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D008688:Methacholine Compounds; D000515:alpha 1-Antitrypsin; D016210:Methacholine Chloride; D007073:Immunoglobulin E