Hemodynamic changes after ruthenium irradiation of Hippel's angiomatosis.
The authors report a case of Hippel's angiomatosis successfully treated with contact beta irradiation. The area of the multiplex retinal angioma and the accompanying retinal detachment was irradiated with a 106Ru/106Rh radioactive applicator. Hemodynamic changes due to irradiation were followed up in the ipsilateral ophthalmic artery with transcranial Doppler sonography. Scarring was also demonstrated by fluorescein angiography and A- and B-scan ultrasonography. Irradiation caused the narrowing and later the occlusion of the precapillaries and capillaries (i.e. the resistance vessels) and that of the shunts inside the angioma; consequently, vascular resistance increased. Transcranial Doppler sonographic recordings showed a decrease in blood flow velocity as compared to pathologically increased blood flow velocity in angiomas, and a gradual increase in vascular resistance which was lower before treatment.
Balázs
E
E
Department of Ophthalmology, University Medical School of Debrecen, Hungary.
Berta
A
A
Rózsa
L
L
Kolozsvári
L
L
Rigó
G
G
D000328:Adult; D000798:Angiomatosis / Q000532:radiotherapy*; D005134:Eye Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D005260:Female; D005451:Fluorescein Angiography; D006439:Hemodynamics; D006801:Humans; D012164:Retinal Diseases / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D014463:Ultrasonography; D006623:von Hippel-Lindau Disease / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*
D012429:Ruthenium Radioisotopes