Primary hepatic lymphoma presenting as intravascular lymphomatosis.
A case of primary hepatic lymphoma presenting as intravascular lymphomatosis was diagnosed in a 69-year-old woman who presented with symptoms related to the digestive tract. These symptoms were followed by neurologic disorders, including disturbance of sensation and mentality, and pathologic reflexes suggestive of a broad intracerebral lesion. Computed tomography of the brain showed an ill-defined, low-density area in the bilateral parietotemporal lobes. Autopsy revealed a well-circumscribed hepatic tumor, 6 cm in diameter, and scattered hemorrhagic foci in the cerebral cortexes. Microscopically, the hepatic tumor was a diffuse lymphoma, large cell, of the B-cell type. The small vessels of the brain were found to be packed with lymphoma cells, having caused the florid neurologic manifestations.
Kayano
H
H
Department of Pathology, Saitama Medical School, Japan.
Katayama
I
I
D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D010641:Phenotype