[Parthenogenetic development in response to the treatment of mouse oocytes with a weak alkali. Experiments with methylamine].
Ovulated mouse oocytes were incubated in methylamine-containing medium M16 for different periods of time. Methylamine appeared to activate oocytes, and most of them developed by haploid parthenogenesis. Methylamine action depended on its concentration and time of incubation. The data obtained suggest that the increase of intracellular pH unblocks meiosis and activates mammalian oocytes [correction of cocytes].
A P
AP
Dyban
E M
EM
Noniashvili
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006863:Hydrogen-Ion Concentration; D008744:Methylamines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008857:Microscopy, Interference; D008858:Microscopy, Phase-Contrast; D009865:Oocytes / Q000166:cytology / Q000187:drug effects*; D010312:Parthenogenesis / Q000187:drug effects*
D008744:Methylamines; C027451:methylamine
Partenogeneticheskoe razvitie v otvet na obrabotku iaĭtsekletok myshi slaboĭ shcheloch'iu. Opyty s metilaminom.