[A new group of anti-arrhythmia agents (the search, results and concept)].
The current status of the antiarrhythmic therapy is outlined: the main electrophysiological properties underlying the classifications of antiarrhythmic agents are presented; the principles of the search for new drugs are formulated. Using as an example the creation of a new group of antiarrhythmic agents, an attempt was made to develop the concept of the directed search for cardiotropic drugs among tricyclic nitrogen-containing systems.
N V
NV
Kaverina
A P
AP
Skoldinov
D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000145:classification / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology; D003984:Dibenzazepines / Q000627:therapeutic use; D004341:Drug Evaluation; D004594:Electrophysiology; D006801:Humans; D010640:Phenothiazines / Q000627:therapeutic use; D012106:Research; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; D010640:Phenothiazines
Novaia gruppa antiaritmicheskikh sredstv (poisk, rezul'taty, kontseptsiia.