[Valine substitution].
The review deals with analysis of the literature data concerning the importance of valine substitution in certain proteins, namely p21 ras and hemoglobin. A model of the active site of p21 protein is discussed in the light of GTPase activities alterations as a result of monoaminoacid substitution in conservative sites of p21 protein. The established relationship between some forms of transformation and Plasmodium falciparum malaria on the molecular level is shown in a new aspect. The widespread opinion that Hb S is valid as the means of malaria resistance is questioned in terms of new molecular data.
Lalaiants
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Milovanova
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008288:Malaria / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D015689:Oncogene Protein p21(ras) / Q000032:analysis* / Q000235:genetics; D010766:Phosphorylation; D012689:Sequence Homology, Nucleic Acid; D014633:Valine / Q000235:genetics*
D006160:Guanosine Triphosphate; D015689:Oncogene Protein p21(ras); D014633:Valine
Valinovaia zamena.