[Immunopathological study of proliferation-associated antigens in proliferative skin diseases].
59 specimens consisting of 10 psoriasis vulgaris, 1 squamous cell carcinoma, 1 Paget disease, 3 keratoacanthomas, 1 pemphigus vulgaris, 18 cutaneous T cell lymphomas, 2 ATLs, and other skin diseases were studied by immunoperoxidase technique. We used four antibodies to demonstrate a cell proliferation-associated antigen (PC, DNA polymerase-alpha and transferrin receptor) and epidermal growth factor receptor. Our observations suggested that the expression of PC and DNA polymerase-alpha may correlate well with cell proliferation, which were demonstrated in the epidermis of psoriasis vulgaris. Primary and metastatic squamous cell carcinoma and some of psoriasis vulgaris had a positive staining for EGF-R, while normal epidermis and almost all other skin diseases were negative.
Department of Dermatology, Yokohama City University School of Medicine.
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D000941:Antigens / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism; D002455:Cell Division; D004257:DNA Polymerase II / Q000276:immunology; D066246:ErbB Receptors / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D011990:Receptors, Transferrin / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology; D012871:Skin Diseases / Q000276:immunology* / Q000473:pathology
D000941:Antigens; D000954:Antigens, Surface; D019394:Ki-67 Antigen; D011990:Receptors, Transferrin; D066246:ErbB Receptors; D004257:DNA Polymerase II