Activation of the human leukocyte proteinases elastase and cathepsin G by various surfactants.
A systematic study comprising 28 synthetic ionic and nonionic surfactants was carried out in order to examine their effect on the activity of elastase and cathepsin G from human leukocytes against 4-nitroanilide substrates. The whole spectrum, ranging from a complete loss to a pronounced rise in enzymatic activity, was observed at a 0.1% (w/v) surfactant concentration. Most significantly, benzalkonium chloride led to a five-fold increase in elastase activity.
Wenzel
H R
HR
Universität Bielefeld, Fakultät für Chemie.
Feldmann
A
A
Engelbrecht
S
S
Tschesche
H
H
D000813:Anilides / Q000378:metabolism; D000818:Animals; D056649:Cathepsin G; D002403:Cathepsins / Q000378:metabolism*; D002417:Cattle; D004789:Enzyme Activation; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000378:metabolism*; D012697:Serine Endopeptidases; D013501:Surface-Active Agents / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism
D000813:Anilides; D013501:Surface-Active Agents; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase; D014357:Trypsin