The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore.
We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.
J C
JC
Courvalin
K
K
Lassoued
E
E
Bartnik
G
G
Blobel
R W
RW
Wozniak
D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D005455:Fluorescent Antibody Technique; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D008970:Molecular Weight; D009685:Nuclear Envelope / Q000276:immunology*; D009687:Nuclear Proteins / Q000276:immunology*; D011233:Precipitin Tests
D001324:Autoantigens; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins