Interleukin 5 activity in sera from patients with eosinophilia.
Sera from 10 patients with eosinophilia contained eosinophil colony stimulating factor (Eo-CSF) activity. Using anti murine (m) interleukin-5 (IL-5) antibody, we demonstrated that this activity was mainly derived from IL-5. Administration of prednisolone to patients decreased both Eo-CSF activity in sera and the number of eosinophils in blood. These results extend our recent study demonstrating that T cells from eosinophilic patients produce IL-5 with IL-2 stimulation and may support the speculation that IL-5 is an important factor which induces eosinophilia.
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
H
H
Enokihara
H
H
Kajitani
S
S
Nagashima
S
S
Tsunogake
N
N
Takano
K
K
Saito
S
S
Furusawa
H
H
Shishido
Y
Y
Hitoshi
K
K
Takatsu
D001772:Blood Cell Count; D003115:Colony-Stimulating Factors / Q000097:blood; D004802:Eosinophilia / Q000097:blood* / Q000188:drug therapy; D004804:Eosinophils / Q000378:metabolism; D006801:Humans; D015848:Interleukin-5 / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use
D003115:Colony-Stimulating Factors; D015848:Interleukin-5; D011239:Prednisolone