Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama.
1. The metabolic oxidation of debrisoquine (DB) was studied in 89 non-related Cuna Amerindian subjects. 2. Means and standard deviations for urinary recoveries of the intact drug and its 4-hydroxy metabolite (4-HD) were: %DB: 6.8 +/- 4.5; %4-HD: 16.0 +/- 9.1; %sum: 22.8 +/- 12.0. The log10 metabolic ratios for DB (LMRDB) were distributed within a single mode of insignificant skewness (-0.01, P greater than 0.10), which was unimodal (log kernel density and maximum likelihood methods) and normal (chi 2 = 22.5; d.f. = 15; P greater than 0.09; power of the test greater than 80%). 3. Therefore, no poor metabolizers (95% C.I.: 0.1%, 5.2%) were detected in the population sample studied.
Jorge
L F
LF
College of Pharmacy, University of Panamá.
Arias
T D
TD
Inaba
T
T
Jackson
P R
PR
D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007197:Indians, Central American; D010176:Panama; D013223:Statistics as Topic
C012359:4-hydroxydebrisoquin; D003647:Debrisoquin