Improvement of drug absorption through enhancers.
The application of enhancers for improvement of drug absorption via the nasal, transdermal and rectal route are outlined. The importance of the relation between the time course of the enhancing effect and the desired plasma - concentration - time profile of the drug is stressed as well as the need to pay more attention to the safety aspects of absorption enhancers.
de Boer
A G
AG
Division of Pharmacology, University of Leiden, The Netherlands.
van Hoogdalem
E J
EJ
Breimer
D D
DD
D000042:Absorption; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004357:Drug Synergism; D010599:Pharmacokinetics