Drug treatment of dyslipoproteinemia.
The bile-acid sequestrants, nicotinic acid and lovastatin, are the most effective drugs for lowering LDL-cholesterol. Nicotinic acid and gemfibrozil are more effective for lowering triglycerides and increasing HDL. Important considerations for proper selection of drugs in the treatment of the various dyslipoproteinemias are presented. Currently available drugs now permit effective control of blood lipid and lipoprotein levels.
Hunninghake
D B
DB
Heart Disease Prevention Clinic, University of Minnesota, Minneapolis.
D001647:Bile Acids and Salts / Q000378:metabolism; D002994:Clofibrate / Q000627:therapeutic use; D003327:Coronary Disease / Q000517:prevention & control; D004359:Drug Therapy, Combination; D015248:Gemfibrozil / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006951:Hyperlipoproteinemias / Q000188:drug therapy*; D007009:Hypolipoproteinemias / Q000188:drug therapy*; D009525:Niacin / Q000378:metabolism; D011341:Probucol / Q000627:therapeutic use
D001647:Bile Acids and Salts; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009525:Niacin; D002994:Clofibrate; D011341:Probucol; D015248:Gemfibrozil