[Chemosensibility of Plasmodium falciparum in Africa south of the Sahara: evaluation of two and a half years' research at the Tropical Medicine Institute of the Health Service of the French Armed Forces].
From March 1987 to June 1989, 194 isolates of Plasmodium falciparum were studied in vitro by the isotopic semi-microtest. 86.1% were resistant to chloroquine; 9.5% had a decrease of sensibility to quinine and 3.3% a decrease of sensibility to mefloquine. There was a positive correlation between I.C. 50 of the antimalarial drugs compared by pairs.
Service de Médecine des Collectivités, Institut de Médecine Tropicale du Service de Santé des Armées, Marseille.
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A
Spiegel
J C
JC
Doury
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D
Daumerie
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D
Baudon
D000293:Adolescent; D000328:Adult; D000353:Africa, Southern; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*; D012680:Sensitivity and Specificity
D011804:Quinolines
Chimiosensibilité du Plasmodium falciparum en Afrique subsaharienne. Bilan de deux ans et demi d'étude à l'Institut de Médecine Tropicale du Service de Santé des Armées.