The paradoxical stress response: a possible common basis for depression and other conditions.
This paper assumes that there are two types of stress-related pathology, the orthodox and the paradoxical, both depending on a positive feedback mechanism controlling the stress-related sympathetic discharge. The paradoxical stress response is speculated to be the common basis for a group of conditions, including depression, panic attacks, obesity, sexual deviations, alcoholism, and drug addiction. Evidence is provided that trazodone inhibits the stress-related sympathetic discharge. This would provide a rationale for its use not only in depression, but also in other conditions depending on an exaggeration of the orthodox or paradoxical stress response.
Institute of Pharmacology and Pharmacognosy, University of Rome, La Sapienza, Italy.
B
B
Silvestrini
D000818:Animals; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D013312:Stress, Physiological / Q000150:complications*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014196:Trazodone / Q000627:therapeutic use
D014196:Trazodone