[Dependence of bronchial hyperreactivity on the initial value of airway resistance].
In 403 patients, the influence of the initial value of the airway resistance on the incidence and extent of a positive reaction after an unspecific inhalative provocation with methacholine was investigated. The higher the original airway resistance was, the greater was the probability of obtaining a positive reaction. At an original resistance of more than 4 cm H2O/l/sec. all patients responded with an increase in airway resistance to more than 6 cm H2O/l/sec. In 91 per cent of these patients, the Rt figure increased more than 100 per cent. The extent of the increase in airway resistance following a positive response was independent of the initial value; the effect of subsequent spasmolysis following a positive test result, showed no dependence on the airway resistance prior to provocation.
Medizinische Universität und Poliklinik der Berufsgenossenschaftlichen Krankenanstalten Bergmannsheil, Bochum.
H P
HP
Hoffarth
W
W
Reier
W T
WT
Ulmer
D000403:Airway Resistance / Q000187:drug effects*; D001985:Bronchial Provocation Tests / Q000379:methods*; D005280:Fenoterol / Q000008:administration & dosage; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis*; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D010993:Plethysmography, Whole Body; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D005280:Fenoterol
Abhängigkeit der bronchialen Hyperreagibilität vom Ausgangswert des Atemwegswiderstandes.