Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain.
Pharmacological management of pain for acute and chronic conditions has been guided by a scientific understanding of peripheral and central acting mechanisms for the control of inflammation as well as pain. Oral surgery pain is a reliable model to reference the effectiveness of commonly used analgesics such as ibuprofen and acetaminophen. A total of 706 patients who were experiencing moderate to severe pain received a single dose of ibuprofen, acetaminophen, or placebo. After 6 hours, the degree of pain relief and tolerance was assessed. Ibuprofen has important implications for postoperative pain in clinical practice.
Biomedical Research Group, Austin, TX.
D R
DR
Mehlisch
W A
WA
Sollecito
J F
JF
Helfrick
D G
DG
Leibold
R
R
Markowitz
C E
CE
Schow
R
R
Shultz
D E
DE
Waite
D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000601:surgery; D015337:Multicenter Studies as Topic; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D014070:Tooth / Q000601:surgery
D010919:Placebos; D000082:Acetaminophen; D007052:Ibuprofen