[Thrombocyte growth factor].
PDGF is one of the principal mitogens for cultured cells of mesenchymal origin. Apart from aggregated platelets PDGF can be secreted by a number of cells. There is a striking homology between the amino-acid sequence of PDGF and that of a transforming protein of simian-sarcoma virus. PDGF is an important chemotactic protein for cells implicated in wound healing. Furthermore, recent publications suggest a possible role in the pathogenesis of several diseases. This article summarizes studies and recent findings on the structure, biology, and functional role of PDGF.
Buck
C
C
Medizinische Universitätsklinik und Poliklinik, Abteilung Innere Medizin III-Hämatologie/Onkologie, Ulm.
Montenarh
M
M
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000737:chemistry* / Q000502:physiology
D010982:Platelet-Derived Growth Factor
Thrombozyten-Wachstumsfaktor.