[Endogenous metabolites as modulators of the transport of drugs by serum albumin].
The ability of serum albumin to bind reversibly on its surface drugs and to transport them in the process of distribution and elimination has been well established. Some endogenous metabolites, particularly unesterified fatty acids, bile acids, L-tryptophan and bilirubin which are formed both under physiological conditions and in pathological states of the organism, e.g., in uremia can displace drugs from their areas of binding on albumin molecule. The detection of endogenous metabolites and the study of the mechanism through which they displace drugs from the specific areas on plasma proteins is the urgent task of pharmacology.
Bender
K I
KI
Lutsevich
N F
NF
Lutsevich
A N
AN
Kupchikov
V V
VV
D000079:Acetaldehyde / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood; D006493:Heparin / Q000097:blood; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011453:Prostaglandins / Q000097:blood; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D012709:Serum Albumin / Q000378:metabolism*
D001647:Bile Acids and Salts; D001786:Blood Glucose; D005227:Fatty Acids; D004364:Pharmaceutical Preparations; D011453:Prostaglandins; D012709:Serum Albumin; D006493:Heparin; D000079:Acetaldehyde; D001663:Bilirubin
Endogennye metabolity kak moduliatory transporta lekarstvennykh veshchestv syvorotochnym al'buminom.