Renal effects of the non-ionic contrast medium iopentol after intravenous injection in healthy volunteers.
Renal effects of the new non-ionic contrast medium iopentol in increasing doses were assessed and compared with the effects of physiologic saline. Twenty-four healthy male volunteers, allocated to three dose groups, were given iopentol intravenously in doses of 0.3, 0.6, and 1.2 g I/kg body weight, respectively. The highest dose group was also given physiologic saline separately as a control. The diuresis increased in all groups, most in the highest dose group, and with a concomitant fall of urine osmolality and increase in osmolar clearance. A slight decrease of serum osmolality, creatinine and urea occurred at 3 hours due to hemodilution. The glomerular filtration rate was unaffected by iopentol. The urinary excretion of albumin and beta 2-microglobulin was unchanged. However, urinary N-acetyl-beta-glucosaminidase and alkaline phosphatase increased significantly, most in the highest dose group. All changes were reversible.
Department of Radiology, Rikshospitalet, Oslo, Norway.
J A
JA
Jakobsen
K J
KJ
Berg
A
A
Waaler
E
E
Andrew
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000419:Albuminuria; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood / Q000652:urine; D006801:Humans; D007275:Injections, Intravenous; D007463:Iodobenzoates / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D009994:Osmolar Concentration; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D014508:Urea / Q000097:blood / Q000652:urine; D014556:Urine; D001613:beta 2-Microglobulin / Q000652:urine
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D001613:beta 2-Microglobulin; C053571:iopentol; D014508:Urea; D003404:Creatinine; D000118:Acetylglucosaminidase