Erythema multiforme and Stevens-Johnson syndrome. Descriptive and therapeutic controversy.
Diagnosis and particularly the management of erythema multiforme and Stevens-Johnson syndrome are controversial in medical textbooks and thus in individual cases. In these diseases, fatalities may result from various causes, including secondary infection or visceral organ damage to lung, liver, or kidneys. We present a series of 13 cases managed by one group of physicians which demonstrates the controversy in certain cases, and we review the controversy in the medical literature. Corticosteroid therapy used in this series was considered beneficial in every case by the managing physician and lifesaving in some cases. There were no fatalities in this series. Although the summation may be considered as our opinion only, the frequently suggested "controlled trial of corticosteroid therapy" can probably never be done for ethical reasons, and series such as this will have to establish the standard of therapy.
Patterson
R
R
Department of Medicine, Northwestern University Medical School, Chicago.
Dykewicz
M S
MS
Gonzalzles
A
A
Grammer
L C
LC
Green
D
D
Greenberger
P A
PA
McGrath
K G
KG
Walker
C L
CL
D004892:Erythema Multiforme / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy; D009626:Terminology as Topic
D011241:Prednisone; D006854:Hydrocortisone