Maternal hormone manipulations and the development of obesity in rats.
Pregnant rats were injected with either insulin, corticosterone, thyroxin, or saline during the third trimester (week) of pregnancy. Offspring from these groups had equivalent body weights at birth and at weaning. However, beginning at approximately seven weeks of age, male offspring in the insulin condition gained weight at significantly higher rates than their counterparts in the other three conditions. This increase in body weight was accompanied by a significant increase in carcass lipid content. These effects were not observed in female offspring.
Jones
A P
AP
Department of Psychology, Pitzer College, Claremont, CA 91711.
Dayries
M
M
D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005865:Gestational Age; D007328:Insulin / Q000097:blood*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012733:Sex Differentiation / Q000502:physiology; D013974:Thyroxine / Q000097:blood
D007328:Insulin; D013974:Thyroxine; D003345:Corticosterone