The prevention of natural motoneuron cell death by dibutyryl-cyclic GMP in the spinal cord of White Leghorn chick embryos.
The effect of dibutyryl-cyclic guanosine monophosphate (db-cGMP) treatment of White Leghorn chick embryos on the extent of natural motoneuron cell death in the lumbar spinal cord was examined. A dose of 1.59 mumol of db-cGMP effected an increase in motoneuron survival of 26.7%. No effect on motoneuron survival was observed with equimolar doses of 8-bromo-cGMP, db-cAMP, GMP, guanosine, or butyric acid.
Department of Neurology, Louisiana State University Medical Center, New Orleans 70112.
C L
CL
Weill
D P
DP
Greene
D000818:Animals; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000196:embryology*
D003995:Dibutyryl Cyclic GMP