[Incidence of secondary tumors following cervical neoplasia in Saarland 1968-1987].
In 4468 patients diagnosed with invasive cancer or carcinoma in situ of the uterine cervix in Saarland/W-Germany in 1968-1987, 149 secondary cancers were observed compared to 150.6 which would have been expected had the same risk prevailed as in the general population (SMR = 0.99, 95% confidence interval 0.84-1.17). There were, however, substantial differences between the relative risks for specific cancer sites. For example, the risk of breast cancer was clearly lower than in the general population (SMR = 0.62, 95% confidence interval 0.43-0.88), while the risk of cancer of the urinary bladder was significantly increased (SMR = 2.88, 95% confidence interval 1.53-4.93). The results are consistent with findings from other countries, with current knowledge of risk factor profiles of different malignancies and with hypotheses on possible side effects of radiotherapy.
Brenner
H
H
Saarländisches Krebsregister, Statistisches Landesamt, Saarbrücken.
Stegmaier
C
C
Ziegler
H
H
D002278:Carcinoma in Situ / Q000401:mortality* / Q000532:radiotherapy; D002423:Cause of Death; D003430:Cross-Sectional Studies; D005260:Female; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D009378:Neoplasms, Multiple Primary / Q000401:mortality*; D009381:Neoplasms, Radiation-Induced / Q000401:mortality; D012042:Registries; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000532:radiotherapy
Untersuchungen zum Auftreten von Zweittumoren nach Zervixneoplasien im Saarland 1968-1987.