Neurochemical substrates of human aging and dementia.
Further development of clinical models of dementia to augment present unsatisfactory animal models, is of central importance to the understanding of the neurochemistry of dementia. Furthermore, present definitions of the neurotoxic processes underlying dementing disorders will need to be improved. Routine clinical markers will be necessary for the development of any therapy beyond present attempts for symptomatic treatment with neurotransmitter replacement.
Medical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD.
E
E
Mohr
C
C
Carter
A
A
Wallin
D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism / Q000523:psychology; D000818:Animals; D001923:Brain Chemistry; D003704:Dementia / Q000378:metabolism*; D006801:Humans