Recent advances in the generation of chiral intermediates using enzymes.
Different types of enzyme-catalyzed processes are reviewed, with particular regard to those procedures leading to the generation of chiral compounds of high optical purity. The main body of the review deals with hydrolyses and esterification as well as the reduction and oxidation of organic substrates. Other biotransformations of current and/or future importance in the synthesis of homochiral fine chemicals (such as the formation of carbon-carbon bonds using aldolases) are also discussed in some detail. Attention is drawn to current trends in the area and, to this end, a majority of the references are taken from journals published during the period April 1987 to September 1988.
Department of Medicinal Chemistry, Glaxo Group Research, Greenford, Middlesex, U.K.
H G
HG
Davies
R H
RH
Green
D R
DR
Kelly
S M
SM
Roberts
D000438:Alcohols; D000475:Alkenes; D000577:Amides; D001709:Biotechnology; D001711:Biotransformation; D004798:Enzymes; D004952:Esters; D006868:Hydrolysis; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000438:Alcohols; D000475:Alkenes; D000577:Amides; D004798:Enzymes; D004952:Esters