Researches on antibacterial and antifungal agents, XII: Analogues of bifonazole with two imidazole moieties and related azoles.
Analogues of bifonazole bearing two imidazole rings and other related azoles have been synthesized and tested as antifungal agents against Candida albicans and Candida spp.. Only a slight part of the antifungal power of the parent drug is retained by some derivatives as evinced by the comparison of new compounds with bifonazole, miconazole, and ketoconazole.
Stefancich
G
G
Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza.
Silvestri
R
R
Panico
S
S
Artico
M
M
Simonetti
N
N
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D001393:Azoles; D007093:Imidazoles; C036596:bifonazole