Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus.
Abiesenonic acid methyl ester (AVB-I acid methyl ester), a triterpenoid compound prepared from abieslactone, suppressed tumor promoter-induced phenomena in vitro and in vivo; i.e., AVB-I acid methyl ester inhibited 12-o-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells and the promoting action of TPA on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
J
J
Takayasu
R
R
Tanaka
S
S
Matsunaga
H
H
Ueyama
H
H
Tokuda
T
T
Hasegawa
A
A
Nishino
H
H
Nishino
A
A
Iwashima
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D007783:Lactones / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014197:Trees; D014315:Triterpenes / Q000494:pharmacology*
D002273:Carcinogens; D007783:Lactones; D010743:Phospholipids; D014315:Triterpenes; C066058:abieslactone; D013755:Tetradecanoylphorbol Acetate