[Possible role of malonic dialdehyde in the regulation of cell division].
Malonic dialdehyde (MDA) crosslinking of complementary chains of DNA is suggested. It contributes to the stabilization of the DNA helix, making its replication impossible. MDA is considered as a cell division inhibitor. The MDA-producing process (lipid peroxidation) is considered to be a normal strictly controlled in vivo process. Control of rest and proliferation alternations in normal cells and its impairment in transformed cells are discussed in terms of the proposed idea.
Dmitriev
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LF
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*
D008314:Malonates; D008315:Malondialdehyde
Vozmozhnaia rol' malonovogo dial'degida v reguliatsii kletochnogo deleniia.