title: Isolated primary aldosteronism in a patient with adrenal carcinoma and XY/XXY mosaic Klinefelter's syndrome.
abstract: Although breast cancer, germ cell tumors and other neoplasms are known to occur in patients with Klinefelter's syndrome, adrenal carcinoma has not yet been reported in such patients. We describe a rare case of severe primary aldosteronism as the unique manifestation of a large adrenocortical carcinoma in a patient with Klinefelter's syndrome. Complete biological and hormonal evaluation was performed. Surgical treatment was successful and the patient remained asymptomatic with normal biological and hormonal values after 1 year of followup.
authors.affiliation: Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pascual
authors.forename: F
authors.initials: F
authors.lastname: Liaño
authors.forename: A
authors.initials: A
authors.lastname: García-Villanueva
authors.forename: J L
authors.initials: JL
authors.lastname: Salvador
authors.forename: J A
authors.initials: JA
authors.lastname: Herrero
authors.forename: J
authors.initials: J
authors.lastname: Ortuño
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000235:genetics; D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000235:genetics; D006801:Humans; D006929:Hyperaldosteronism / Q000209:etiology*; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications / Q000235:genetics*; D008297:Male; D009030:Mosaicism