Must clinical trials be large? The interpretation of P-values and the combination of test results.
The notion that small, well planned clinical trials may not be worth undertaking is shown to arise from an overemphasis on just one way of interpreting P-values. Alternative forms of P and other interpretations are put forward. Attention is drawn to some aspects of the theory of hypothesis testing which seem less well known than they should be.
Barnard
G A
GA
University of Essex, Wivenhoe Park, Colchester, U.K.
D016010:Binomial Distribution; D002986:Clinical Trials as Topic / Q000379:methods*; D011336:Probability; D012107:Research Design; D013223:Statistics as Topic