Cardiovascular responses to tracheal intubation after thiopentone or propofol.
The hemodynamic responses to laryngoscopy and intubation were compared in forth patients of ASA class I-II undergoing various surgical procedures without premedication were randomly divided into two groups and given propofol (2.5 mg/kg) or thiopentone (5 mg/kg) for induction, and succinylcholine (1.5 mg/kg) for facilitating laryngoscopy and intubation. Each group consisted 20 patients. Baseline data has no significant difference between the two groups. After induction systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) heart rate (HR), cardiac output (CO), cardiac index (CI) were all lower in the propofol group than thiopentone group. It indicate that propofol (2.5 mg/kg) has more cardiovascular depressive effects than thiopentone (5 mg/kg). Local injection pain was complained by every patient.
Tzen
C C
CC
Department of Anesthesiology, College of Medicine and Hospital, National Cheng Kung University.
Tsai
Y J
YJ
Chang
C L
CL
D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*
D013874:Thiopental; D015742:Propofol