Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry.
Fluoxymesterone, an anabolic steroid, is metabolized in man primarily by 6 beta-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. These pathways of metabolism are suggested by the positive identification of 4 metabolites and the tentative identification of 3 other metabolites. Detection of the drug in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males, by monitoring the presence of 2 metabolites, since the parent drug is not detectable more than 1 day after the dose.
Kammerer
R C
RC
Paul Ziffren Olympic Analytical Laboratory, UCLA Department of Pharmacology, School of Medicine 90024.
Merdink
J L
JL
Jagels
M
M
Catlin
D H
DH
Hui
K K
KK
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005474:Fluoxymesterone / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008954:Models, Biological; D019966:Substance-Related Disorders / Q000652:urine
D005474:Fluoxymesterone