Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis.
The effect of acute oral administration of 2 g vitamin C on bronchial responsiveness to inhaled histamine in 16 patients with allergic rhinitis was compared with placebo on two consecutive days in a double-blind, crossover design. The PC15FEV1 was significantly increased one hour after treatment with vitamin C but not after placebo.
Bucca
C
C
Dpt. di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Rolla
G
G
Oliva
A
A
Farina
J C
JC
D000280:Administration, Inhalation; D000328:Adult; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008448:Maximal Expiratory Flow Rate; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000503:physiopathology*
D006632:Histamine; D001205:Ascorbic Acid