Effect of angiotensin-converting enzyme inhibitor on salt appetite and thirst of BALB/c mice.
The role of angiotensin II (ANG II) in Na-depletion-induced Na appetite of mice was investigated. Intraperitoneal injection of the angiotensin-converting enzyme inhibitor captopril at 1.7 mg/mouse (high dose) decreased the Na intake of the Na-depleted (furosemide-treated) mice by 80-85%. The decrease in Na intake was restored to the initial level by concurrent subcutaneous infusion of ANG II. High dose of captopril also decreased the Na intake of fluid-deprived, Na-depleted mice. High dose of captopril did not alter water intake in any of the four conditions examined, i.e., in fluid-replete, Na-depleted, water-deprived, or fluid-deprived, Na-depleted mice. Low dose of captopril (1.7 microgram/mouse) tended to or significantly enhanced Na intake of Na-depleted mice. Low dose of captopril, however, did not enhance water intake in any of the conditions examined. Both high- and low-dose captopril treatment decreased food intake in water-deprived mice, whether or not the mice were Na depleted as well. The addition of captopril (0.1 or 1.0 mg/ml) to the drinking water did not influence Na or food intake. Water intake was enhanced during treatment with the low but not with the high dose of captopril. The results are consistent with the proposition that ANG II is involved in the Na appetite of Na-depleted mice. ANG II does not appear to have a role in water intake of Na-depleted or water-deprived mice, but neural mechanisms in which angiotensin has a role may influence food intake of water-deprived mice.
Weisinger
R S
RS
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Blair-West
J R
JR
Denton
D A
DA
McBurnie
M
M
Ong
F
F
Tarjan
E
E
Williams
R M
RM
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D004326:Drinking; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012964:Sodium / Q000172:deficiency; D012965:Sodium Chloride; D013894:Thirst / Q000187:drug effects*; D014868:Water Deprivation
D000806:Angiotensin-Converting Enzyme Inhibitors; D012965:Sodium Chloride; D002216:Captopril; D012964:Sodium