Effects of various acidic and alkaline solutions used to dissolve urinary calculi on the rabbit urothelium.
It is well known that infection-induced stones (apatite, struvite), uric acid and cystine calculi in the urinary tract can be managed by the use of certain chemical solutions. We investigated the effects of various acidic and alkaline solutions on the rabbit urothelium. Acidic solutions (pH: 4.2) caused more urothelial injury as compared to alkaline solutions (pH: 7.6). Ureteral injury was more severe than the bladder injury. Magnesium-containing solutions caused less injury to the urothelium.
Dönmez
T
T
Department of Urology, University of Anadolu School of Medicine, Eskişehir, Turkey.
Erol
K
K
Gürer
F
F
Bayçu
C
C
Açikalin
E
E
Cingi
M I
MI
D000818:Animals; D002119:Calcium Carbonate / Q000633:toxicity; D002254:Carbonates / Q000633:toxicity*; D002951:Citrates / Q000633:toxicity*; D004338:Drug Combinations; D005260:Female; D006863:Hydrogen-Ion Concentration; D008277:Magnesium Oxide / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D007507:Therapeutic Irrigation; D014513:Ureter / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*; D014545:Urinary Calculi / Q000628:therapy*
D002254:Carbonates; D002951:Citrates; D004338:Drug Combinations; C050615:Suby's G solution; D008277:Magnesium Oxide; D002119:Calcium Carbonate