Genotoxic effects of thiram evaluated by sister-chromatid exchanges in human lymphocytes.
The purpose of this investigation was to study the genotoxic potential of thiram (CAS No. 137-26-8) using an in vitro sister-chromatid exchange (SCE) assay with human lymphocytes. The results indicate that thiram and its metabolites increase the SCE frequencies 2-fold over those observed in the negative controls. The standard inducers cyclophosphamide and ethyl methanesulfonate increased SCE frequencies 10- and 4-fold, respectively, over untreated levels.
Pienkowska
M
M
Department of Biochemistry, Warsaw Medical School, Poland.
Zielenska
M
M
D000818:Animals; D001711:Biotransformation; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013893:Thiram / Q000378:metabolism / Q000494:pharmacology*
D009153:Mutagens; D013893:Thiram; D003520:Cyclophosphamide; D005020:Ethyl Methanesulfonate