Studies on the effect of ascorbic acid and selenium on the genotoxicity of nitrofurans: nitrofurazone and furazolidone.
The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest.
Gajewska
J
J
Department of Biochemistry, Institute of Biopharmacy, Medical School, Warsaw, Poland.
Szczypka
M
M
Tudek
B
B
Szymczyk
T
T
D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics; D005664:Furazolidone / Q000037:antagonists & inhibitors* / Q000633:toxicity; D016296:Mutagenesis / Q000187:drug effects; D009153:Mutagens / Q000037:antagonists & inhibitors*; D009583:Nitrofurazone / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013014:SOS Response, Genetics / Q000187:drug effects; D012486:Salmonella typhimurium / Q000235:genetics; D012643:Selenium / Q000494:pharmacology*
D000975:Antioxidants; D009153:Mutagens; D005664:Furazolidone; D012643:Selenium; D001205:Ascorbic Acid; D009583:Nitrofurazone