title: Effects of fetal intravenous glucose challenge in normal and growth retarded fetuses.
abstract: Fetal intravenous glucose challenge test (0.75 g/kg of estimated fetal weight) was performed at 26-33 weeks gestation in 9 patients undergoing fetal blood sampling (FBS) by ultrasound guided needling from the umbilical vein. The indication for FBS was rapid karyotyping for fetal malformations in 5 (control group) and severe intrauterine growth retardation in the remaining 4 (IUGR group). Fetal blood samples were taken before the glucose infusion and after 1, 3, 5, 10 and 15 min; glucose and insulin were assayed on each occasion and acid-base balance at 0 and 5 min. Basal fetal pO2, pH, glucose and insulin were lower in the IUGR group than in controls. Following the glucose challenge, fetal glucose levels were similar in the two groups, but in the IUGR group the latter part of the glucose curve was characterized by a slower and delayed return to basal levels. In control fetuses the insulin response following the glucose challenge peaked at 3 min while in IUGR no change in insulin concentration was detected. Fetal pO2 did not change in either group; the median change in fetal pH was significantly different between the two groups (controls: +0.01; IUGR: -0.04; P less than 0.05) and there was a significant correlation between basal pO2 and the change in fetal pH (r = 0.79) (P less than 0.02). These results support the concept of a low energy state in IUGR. Fetal glucose supplementation in IUGR is unlikely to be of benefit and may even exacerbate underlying acidosis.
authors.affiliation: Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London, United Kingdom.
authors.forename: U
authors.initials: U
authors.lastname: Nicolini
authors.forename: C
authors.initials: C
authors.lastname: Hubinont
authors.forename: J
authors.initials: J
authors.lastname: Santolaya
authors.forename: N M
authors.initials: NM
authors.lastname: Fisk
authors.forename: C H
authors.initials: CH
authors.lastname: Rodeck
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000378:metabolism / Q000502:physiology; D007621:Karyotyping; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D014882:Water-Electrolyte Balance
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D010100:Oxygen