title: Correlates of middle cerebral artery blood velocity in the elderly.
abstract: We analyzed the association between hematologic factors and blood velocity of the middle cerebral artery in 42 healthy ambulatory subjects aged 63-86 years. We found a significant inverse association between mean velocity and both hematocrit (r = -0.37, p less than 0.02) and fibrinogen concentration (r = -0.42, p less than 0.005). These two variables are independently associated with velocity and together explain 29% of the variance in mean velocity. Both hematocrit and fibrinogen concentration should be considered in the interpretation of transcranial Doppler findings in this population.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: S F
authors.initials: SF
authors.lastname: Ameriso
authors.forename: A
authors.initials: A
authors.lastname: Paganini-Hill
authors.forename: H J
authors.initials: HJ
authors.lastname: Meiselman
authors.forename: M
authors.initials: M
authors.lastname: Fisher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000502:physiology*; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000502:physiology*; D004453:Echoencephalography; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D005340:Fibrinogen