title: Importance of acid-base strategy in reducing myocardial and whole body oxygen consumption during perfusion hypothermia.
abstract: During induced hypothermia with cardiopulmonary bypass, acid-base management usually follows one of two strategies: the so-called ectothermic or alpha-stat strategy, in which the pH of the arterial blood increases 0.015 pH units for every degree Celsius decrease in body temperature, or the pH-stat strategy, in which pH remains 7.4 at all temperatures. It has been assumed that oxygen consumption decreases approximately equally during hypothermia with either strategy, although there are biochemical reasons to hypothesize that oxygen consumption would be better maintained with the alpha-stat strategy. We also hypothesized that venous oxygen tension would be lower with the more alkaline alpha-stat strategy than with the pH-stat acid-base strategy, because of the Bohr effect. We tested these hypotheses by placing 10 anesthetized immature domestic pigs on cardiopulmonary bypass. We measured whole body oxygen consumption and myocardial oxygen consumption. Control measurements were made at 37 degrees C. Then the animals were cooled to 27 degrees C and the measurements were repeated. The alpha-stat strategy (pH 7.554 +/- 0.020 at 27 degrees C) was used in five animals and five animals received pH-stat management (pH 7.409 +/- 0.012 at 27 degrees C). Whole body and myocardial oxygen consumption rate decreased in both groups, but more so in the alpha-stat animals than in the pH-stat animals. The unexpectedly high oxygen consumption in the pH-stat animals also resulted in a lower than expected venous oxygen tension. Thus the effect of hypothermia in reducing oxygen consumption was less pronounced with pH-stat acid-base management.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093.
authors.forename: D C
authors.initials: DC
authors.lastname: Willford
authors.forename: W Y
authors.initials: WY
authors.lastname: Moores
authors.forename: S Y
authors.initials: SY
authors.lastname: Ji
authors.forename: Z T
authors.initials: ZT
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Palencia
authors.forename: P O
authors.initials: PO
authors.lastname: Daily
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D013552:Swine
chemical_list: D010100:Oxygen; D009638:Norepinephrine