Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones.
The effect of anabolic steroid therapy and estrogen-progestogen substitution therapy on serum concentration of procollagen type III aminoterminal peptide (PIIINP), a measure of collagen synthesis, in postmenopausal women was studied in two double-blind studies: (1) 39 women allocated to treatment with either 50 mg nandrolone decanoate as an intramuscular depot or placebo injections every third week for 1 year, and (2) 40 women allocated to receive either 2 mg 17 beta-estradiol plus 1 mg norethisterone acetate daily or placebo tablets for 1 year. Serum PIIINP was measured every 3 months during the study. Anabolic steroid therapy resulted in a more than 50% increase (P less than .001) in serum PIIINP at 3 months, which thereafter decayed but remained significantly increased throughout the study period. Serum PIIINP showed the same pattern during estrogen-progestogen therapy, but to a lesser degree. We conclude that anabolic steroids stimulate type III collagen synthesis in postmenopausal women, while estrogen-progestogen therapy may have such an effect, but only to a lesser degree.
Hassager
C
C
Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
Jensen
L T
LT
Pødenphant
J
J
Riis
B J
BJ
Christiansen
C
C
D000368:Aged; D045930:Anabolic Agents / Q000627:therapeutic use*; D003094:Collagen / Q000096:biosynthesis*; D004338:Drug Combinations; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood
D045930:Anabolic Agents; D004338:Drug Combinations; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D004958:Estradiol; D009277:Nandrolone; D003094:Collagen; D000077563:Norethindrone Acetate; D000077603:Nandrolone Decanoate; D009640:Norethindrone