title: [A case of local recurrent breast cancer with complete response to combination of systemic chemotherapy and topical use of adriamycin ointment].
abstract: A Case of local recurrent breast cancer in a 45-year-old female with complete response to Combination of chemotherapy and topical administration of Adriamycin is reported. The patient had left mastectomy for breast cancer in 1978, and then right mastectomy for breast cancer in 1987. Two years later, she was readmitted to our hospital with right neck lymph node metastasis and local recurrence at right chest wall. Neck lymph node metastasis was treated with irradiation with good response. On the other hand, Adriamycin ointment was applied to recurrent cancer on the right chest. The cancer was gradually diminished in size. Seventy-eight days after treatment, the local chest wall with cancer was resected. Histologically, the entire resected tissue showed no viable cancer cells and Adriamycin concentration in the tissue was extraordinary high (ten to forty fold over on systemic chemotherapy). Adriamycin ointment may be an alternative treatment of choice for local recurrent breast cancer.
authors.affiliation: Dept. of Surgery 1, School of Medicine, University of the Ryukyus.
authors.forename: S
authors.initials: S
authors.lastname: Deguchi
authors.forename: K
authors.initials: K
authors.lastname: Kurihara
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: A
authors.initials: A
authors.lastname: Hokama
authors.forename: Y
authors.initials: Y
authors.lastname: Muto
authors.forename: T
authors.initials: T
authors.lastname: Toda
mesh_terms: D000287:Administration, Topical; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015409:Mastectomy, Radical; D008525:Medroxyprogesterone / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009824:Ointments; D012074:Remission Induction; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D009824:Ointments; D005641:Tegafur; D014498:Uracil; D004317:Doxorubicin; D008525:Medroxyprogesterone; D002945:Cisplatin