[Effectiveness of topical selective decontamination, without systemic antibiotic prophylaxis, in prevention of pulmonary infection in intensive care].
Forty-seven patients admitted in our general ICU and treated with Selective Digestive Decontamination (SDD) without any systemic antibiotic prophylaxis, were prospectively studied and compared with an historical group of 50 non treated subjects. The 2 groups were no different as to underlying disease, age, sex and prognostic index (SAPS). In the treated group was recorded an important and statistically significant reduction in the incidence of pneumonia and in the frequency of pulmonary infections caused by enterobacteriaceae and pseudomonceae. Gram-positive identification in tracheal aspirates was not significantly different in the two groups as well as the incidence of "early pneumonia". In the treated group, a sharp decrease of the total amount of fever-days through ICU stay was observed. The antibiotic consumption resulted to be an overall 28.3% lower in the group treated with, SDD with particular regard to broad-spectrum ones.
Nardi
G
G
2. Servizio di Anestesia e Rianimazione, Ospedale Regionale di Udine.
Valentinis
U
U
Bartaletti
R
R
Bello
A
A
De Monte
A
A
Muzzi
R
R
Giordano
F
F
Troncon
M G
MG
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003422:Critical Care; D004203:Disinfection; D005260:Female; D006801:Humans; D008297:Male; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents
Efficacia della sola decontaminazione selettiva, senza profilassi antibiotica sistemica, nella prevenzione delle infezioni polmonari in terapia intensiva.