Can chlorpromazine prevent flap necrosis?
The influence of chlorpromazine hydrochloride on failing, cranially-based dorsal flaps of female rats (Uje:WIST) was studied. The drug was injected subcutaneously into the abdomen pre- and postoperatively. The dosage was 1.5 mg/100 g preoperatively and 0.75 mg/100 g body weight every 12 hours following flap replantation for 10 consecutive days. No improvement in the survival rate was achieved by administration of chlorpromazine hydrochloride in this rat strain.
Höft
H D
HD
Department of Maxillo-Facial Surgery and Plastic Surgery, Friedrich Schiller University, Jena, German Democratic Republic.
Oswald
P
P
Tilgner
A
A
Schumann
D
D
D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D009336:Necrosis; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps / Q000473:pathology
D002746:Chlorpromazine