title: Whither short-course chemotherapy for tuberculous meningitis?
abstract: Short-course chemotherapy is well established for the treatment of pulmonary tuberculosis but not for extrapulmonary disease. We present a series of 35 cases in which chemotherapy for tuberculous meningitis was given for a period of less than 2 years. Short-term therapy was associated with recrudescence of tuberculous meningitis and, in some cases, with the development of deep cerebral infarcts and permanent neurological deficits. We think short-term chemotherapy for tuberculosis of the central nervous system is inadequate.
authors.affiliation: Department of Neurosurgery Seth GS Medical College, Bombay, India.
authors.forename: A
authors.initials: A
authors.lastname: Goel
authors.forename: S K
authors.initials: SK
authors.lastname: Pandya
authors.forename: A R
authors.initials: AR
authors.lastname: Satoskar
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000209:etiology; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D009896:Optic Atrophy / Q000209:etiology; D012008:Recurrence; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000995:Antitubercular Agents