Immunological features in a case of hypereosinophilic syndrome and myocarditis.
The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the immunological features of autoreactive myocarditis: cytolytic, complement-fixing antimyolemmal antibodies and increased concentrations of circulating immune complexes were present over 3 years.
Maisch
B
B
Department of Internal Medicine and Cardiology, Philipps-University Marburg, Federal Republic of Germany.
Drude
L
L
Kochsiek
K
K
D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D001706:Biopsy; D015153:Blotting, Western; D004452:Echocardiography; D004696:Endocarditis / Q000276:immunology*; D004699:Endocardium / Q000276:immunology; D004802:Eosinophilia / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D009206:Myocardium / Q000276:immunology
D001323:Autoantibodies