Determination of plasma concentrations of cyclandelate and mandelic acid in patients with generalized atherosclerotic vasculopathy treated with oral cyclandelate.
Cyclandelate, a vasoactive substance consisting of the mandelic acid ester of 3,3,5-trimethylcyclohexanol, was administered to 10 patients with cerebrovascular and/or peripheral vascular disease. Blood specimens were collected at 1-6 h after oral administration of 1600 mg cyclandelate, and the ester and acid were extracted from plasma in acid medium using n-hexane/isopropyl alcohol. The concentrations were determined by a high-performance liquid chromatography isocratic system. The highest plasma cyclandelate concentrations were detected at the third hour, whereas plasma mandelic acid concentrations were still increasing 6 h after administration.
Forconi
S
S
Division of Gerontology and Geriatrics, University of Siena, Italy.
Cappelli
R
R
Guerrini
M
M
Volpi
L
L
Frigerio
C
C
Di Perri
T
T
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D002851:Chromatography, High Pressure Liquid; D003495:Cyclandelate / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000097:blood*; D008875:Middle Aged; D014652:Vascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000209:etiology
D008333:Mandelic Acids; D003495:Cyclandelate; C037938:mandelic acid