Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.
This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.
Simmons
D J
DJ
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
Yang
C
C
Gundberg
C M
CM
Kidder
L
L
Cornelissen
G
G
Thomas
M
M
Lozano
R
R
Sandstead
E
E
D000818:Animals; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001862:Bone Resorption / Q000503:physiopathology; D002116:Calcitonin / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology*; D004334:Drug Administration Schedule; D005260:Female; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D010758:Phosphorus / Q000097:blood; D051381:Rats
D010758:Phosphorus; D002116:Calcitonin; D002118:Calcium