[Molecular mechanisms of the membrane-protective effect of litonit in chronic stress].
It is confirmed that prophylactic use of Pyracetam (500 mg/kg), Pikamilon (10 mg/kg) and new product of GABA B-44 (30 mg/kg) for 10-days in the conditions of chronic stress normalizes the activity of the key enzymes of antiradical defence and the content of lipid peroxides, warns the decrement of phospholipids and the changes in its qualitative ratio, prevents multidirectional changes in the activity of ferments-markers in the membrane of the brain and erythrocytes. It is concluded that nootropic agents give membrane stabilizing effects.
Kresiun
V I
VI
Rozhkovskiĭ
Ia V
IaV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000187:drug effects; D006937:Hypercholesterolemia / Q000209:etiology / Q000517:prevention & control; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D009539:Nicotinic Acids; D014149:Tranquilizing Agents; C041554:litonit
Molekuliarnye mekhanizmy membranoprotektornogo éffekta litonita pri khronicheskom stresse.