title: [18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies].
abstract: The authors review some current ideas concerning the role of 18-hydroxylated corticosteroids as mineralocorticoids themselves and as possible precursors of the principal mineralocorticoid, aldosterone. In particular, the physiological and pharmacological agents affecting their secretion are discussed together with a description of the methods used for their analysis in plasma in the department of Clinical Biochemistry Pitié-Salpétrière. Finally, the value of these assays in the differential diagnosis of mineralocorticoid hypertension and inborn errors of corticosteroid biosynthesis is assessed and the constraints on sampling technique listed.
authors.affiliation: Service Pr J.C. Legrand, CHU Pitié-Salpétrière, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Aupetit
authors.forename: R
authors.initials: R
authors.lastname: Fraser
authors.forename: P
authors.initials: P
authors.lastname: Vecsei
authors.forename: M
authors.initials: M
authors.lastname: Zenatti
authors.forename: S
authors.initials: S
authors.lastname: Lewicka
authors.forename: P
authors.initials: P
authors.lastname: Corvol
authors.forename: N
authors.initials: N
authors.lastname: Zaugg
authors.forename: J C
authors.initials: JC
authors.lastname: Legrand
mesh_terms: D015069:18-Hydroxycorticosterone / Q000097:blood* / Q000378:metabolism; D015070:18-Hydroxydesoxycorticosterone / Q000097:blood* / Q000378:metabolism; D000307:Adrenal Gland Diseases / Q000097:blood*; D000450:Aldosterone / Q000378:metabolism; D003900:Desoxycorticosterone / Q000378:metabolism; D006801:Humans
chemical_list: D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone
vernacular_title: 18-Hydroxycorticostérone, 18-hydroxydésoxycorticostérone. Pourquoi, quand, comment en déterminer les taux plasmatiques dans certaines pathologies surrénaliennes.