Radioprotective effect of Ganoderma lucidum (Leyss. ex. Fr.) Karst after X-ray irradiation in mice.
Six to seven week old male mice of ICR strain were exposed to 500 or 650 cGy of X-ray during experiments to determine if Ganoderma lucidum could be a factor in modification of radiation damage. Continuous intraperitoneal injection of the extract from Ganoderma lucidum before or after irradiation of 500 and 650 cGy of X-ray was found to improve the 30-day survival fractions of ICR mice, but wasn't significant by statistical analysis. The administration also enhanced the recoveries of the body weights and increased the recovery of hemograms of irradiated mice from radiation damage by injecting before or after radiation exposure, especially for the treatment of 500 cGy irradiation. The 10-day CFUs was significantly higher for Ganoderma lucidum treated groups than for untreated groups. However, the differences of radioprotective effect between the X-ray irradiated groups with Ganoderma lucidum pretreated and post-treated were not significant (p greater than 0.05).
Hsu
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HY
School of Technology for Medical Sciences, Department of Radiotherapy, Kaohsiung Medical College, Taiwan.
Lian
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SL
Lin
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CC
D000726:Androgen Antagonists / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000517:prevention & control
D000726:Androgen Antagonists; D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal