title: Primary Ewing sarcoma: follow-up with Ga-67 scintigraphy.
abstract: While avid accumulation of gallium-67 citrate and technetium-99m methylene diphosphonate (MDP) occurs initially in most cases of primary Ewing sarcoma, uptake after therapy is less well defined. Thirty patients with Ewing sarcoma who underwent Ga-67 and bone scintigraphy at diagnosis, at completion of therapy, and at relapse from 1978 to 1988 were evaluated. All 30 patients showed less primary site Ga-67 activity following therapy. Twenty-three of 28 patients who underwent corresponding bone scintigraphy showed less uptake, but residual activity was usually more intense than with Ga-67. Avid reaccumulation of Ga-67 occurred in four of five patients with primary site relapse, while patients who underwent bone scintigraphy showed less change. It was concluded that a greater decrease in Ga-67 than in Tc-99m MDP uptake often occurs in patients successfully treated for primary Ewing sarcoma. Information obtained at Ga-67 scintigraphy is most likely to be helpful if results of bone scintigraphy remain abnormal or if occult relapse is suspected.
authors.affiliation: Department of Radiology, University of Tennessee, Memphis 38163.
authors.forename: D N
authors.initials: DN
authors.lastname: Estes
authors.forename: H L
authors.initials: HL
authors.lastname: Magill
authors.forename: E I
authors.initials: EI
authors.lastname: Thompson
authors.forename: F A
authors.initials: FA
authors.lastname: Hayes
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D005710:Gallium Radioisotopes