title: Increased expression of the multidrug-resistance gene in undifferentiated sarcoma.
abstract: We analyzed multidrug-resistance gene (mdr1 gene) expression in a patient with undifferentiated sarcoma of the liver using the cloned cDNA for the mdr1 gene. Tissue samples were available at the time of initial diagnosis and of two intracranial relapses after chemotherapy with a regimen including doxorubicin and teniposide. The level of mdr1 gene expression was increased sevenfold in the intracranial tumor at the time of first relapse and 11-fold at the second relapse. This case may be an example of acquired multidrug resistance associated with overexpression of the mdr1 gene.
authors.affiliation: Department of Pediatrics, Osaka University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tawa
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: J
authors.initials: J
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Yumura-Yagi
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: A
authors.initials: A
authors.lastname: Okada
authors.forename: A
authors.initials: A
authors.lastname: Nihei
authors.forename: J
authors.initials: J
authors.lastname: Taguchi
authors.forename: N
authors.initials: N
authors.lastname: Kanai
mesh_terms: D002675:Child, Preschool; D004351:Drug Resistance / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D015151:Immunoblotting; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D012509:Sarcoma / Q000235:genetics*