Is parental age related to the risk of Alzheimer's disease?
Advanced maternal and paternal age were investigated as putative risk factors for AD in 198 clinically diagnosed Alzheimer patients and in 198 randomly selected healthy controls. No significant differences in average age of fathers and of mothers at birth of the subject were observed. The risk of AD was not significantly different across categories of maternal and paternal age. The association with parental age was not different for sporadic and familial AD. These findings do not support the view of a maternal or paternal age effect on AD.
Hofman
A
A
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
van Duijn
C M
CM
Schulte
W
W
Tanja
T A
TA
Haaxma
R
R
Lameris
A J
AJ
Saan
R J
RJ
D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D009426:Netherlands; D010331:Paternal Age; D012307:Risk Factors