title: Determination of plasma concentrations of cyclandelate and mandelic acid in patients with generalized atherosclerotic vasculopathy treated with oral cyclandelate.
abstract: Cyclandelate, a vasoactive substance consisting of the mandelic acid ester of 3,3,5-trimethylcyclohexanol, was administered to 10 patients with cerebrovascular and/or peripheral vascular disease. Blood specimens were collected at 1-6 h after oral administration of 1600 mg cyclandelate, and the ester and acid were extracted from plasma in acid medium using n-hexane/isopropyl alcohol. The concentrations were determined by a high-performance liquid chromatography isocratic system. The highest plasma cyclandelate concentrations were detected at the third hour, whereas plasma mandelic acid concentrations were still increasing 6 h after administration.
authors.affiliation: Division of Gerontology and Geriatrics, University of Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Forconi
authors.forename: R
authors.initials: R
authors.lastname: Cappelli
authors.forename: M
authors.initials: M
authors.lastname: Guerrini
authors.forename: L
authors.initials: L
authors.lastname: Volpi
authors.forename: C
authors.initials: C
authors.lastname: Frigerio
authors.forename: T
authors.initials: T
authors.lastname: Di Perri
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D002851:Chromatography, High Pressure Liquid; D003495:Cyclandelate / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000097:blood*; D008875:Middle Aged; D014652:Vascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000209:etiology
chemical_list: D008333:Mandelic Acids; D003495:Cyclandelate; C037938:mandelic acid