[Drug analysis with polarographic methods. 33. Electroanalytic studies of a new benzodiazepine: [6(o-chlorophenyl)-2,4-dihydro-2-[(4-methyl-1-piperazinyl) methylene]-8-nitro-1H-imidazol[1,2-a][1,4]benzodiazepine-1-one (WHO) (loprazolam,1)] and content determination its drug forms].
Loprazolam (1) is a tricyclic benzodiazepine containing a new butazadiene moiety, which has not been investigated by polarography up to now. 1 is reduced in three waves at a DME over the whole pH-region. In BRP (pH 2-9) 10 electrons are consumed in this process. The first step is suitable for the determination of 1 in Loprazolam tablets containing 1 or 2 mg. These tablets are on the pharmaceutical market in several European countries. The mechanism of the electrode process will be reported in the communication XXXIV.
Oelschläger
H
H
Institut für Pharmazeutische Chemie der Johann Wolfgang Goethe-Universität, Frankfurt a.M.
Volke
J
J
Vetter
M B
MB
Nikolajewski
P
P
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis*; D004563:Electrochemistry; D011048:Polarography; D013607:Tablets
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D013607:Tablets; D001569:Benzodiazepines; C020168:triazulenone
Elektroanalytische Untersuchungen an einem neuen Benzodiazepin: [6-(2- Chlorphenyl)-2-(4-methyl-1-piperazinylmethylen)-8-nitro-2H-imidazol[1,2 -a] [1,4]benzodiazepin-1(4H)-on (VO)(Loprazolam,1)] und Gehaltsbestimmung seiner Arzneiformen.