title: Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate.
abstract: A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
authors.affiliation: Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Verweij
authors.forename: J
authors.initials: J
authors.lastname: Schornagel
authors.forename: P
authors.initials: P
authors.lastname: de Mulder
authors.forename: S
authors.initials: S
authors.lastname: Henzen-Logmans
authors.forename: F
authors.initials: F
authors.lastname: Cognetti
authors.forename: M
authors.initials: M
authors.lastname: Clavel
authors.forename: J
authors.initials: J
authors.lastname: Vermorken
mesh_terms: D000368:Aged; D000630:Aminopterin / Q000031:analogs & derivatives* / Q000633:toxicity; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D004341:Drug Evaluation; D005260:Female; D005493:Folic Acid Antagonists / Q000633:toxicity*; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects*
chemical_list: D005493:Folic Acid Antagonists; C040210:edatrexate; D000630:Aminopterin