[HIV-1 antigenemia and T-cell activation in HIV-1 infected patients].
In order to study a supposed association between T-cell activation in vivo and HIV-1-antigenemia in HIV-1-infected patients, the detection of p24-antigen in sera was correlated to serum levels of beta-2-microglobulin and C1q-binding immune complexes. Anti-p24-antibodies and the urinary excretion of neopterin were also analysed. In 24 of 80 patients (30%) p24-antigen could be detected, and in 15 of 59 (25.4%) there was a loss of anti-p24-antibodies. Tests revealed elevated serum levels of beta-2-microglobulin in 58 of 80 patients (72.5%), elevated levels of C1q-binding immune complexes in 15 of 66 (22.7%), and increased excretion of neopterin in 52 of 60 (86.7%). Detection of p24-antigen, loss of anti-p24-antibodies, serum levels of beta-2-microglobulin, and urinary excretion of neopterin were significantly correlated to advanced stages of HIV-1 infection. Patients with p24-antigen in the serum showed significantly more frequently elevated serum levels of beta-2-microglobulin and no significant association with increased urinary excretion of neopterin. Because of the high proportion of patients with elevated serum levels of beta-2-microglobulin and increased excretion of urinary neopterin in the absence of detectable p24-antigen in serum, we could not correlate HIV-1-antigenemia to T-cell activation in vivo.
Harrer
T
T
Medizinische Universitätsklinik III, Universität Erlangen-Nürnberg.
Wolf
B
B
Kersten
W
W
Schwarz
W
W
Bergner
D
D
Kalden
J R
JR
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D001708:Biopterins / Q000031:analogs & derivatives / Q000032:analysis; D015488:HIV Antigens / Q000302:isolation & purification*; D006801:Humans; D008213:Lymphocyte Activation; D019798:Neopterin; D013601:T-Lymphocytes / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000032:analysis
D015488:HIV Antigens; D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin
HIV-1-Antigenämie und T-Zell-Aktivierung bei HIV-1-infizierten Patienten.