title: Human seminal plasma suppresses the chemiluminescence of polymorphonuclears without modifying phagocytosis.
abstract: The suppressive activity of human seminal plasma was confirmed on the luminol-amplified chemiluminescent reaction of human polymorphonuclears. This suppression was found to be dose-dependent and noncytotoxic. The responsible factor appeared to be a radical scavenger of low molecular weight, acting selectively on hydrogen peroxide. Correlation with glandular markers of semen indicated this molecule to have a prostatic origin. Neither crude seminal plasma nor this factor were found to suppress intracellular engulfment and killing of bacteria. This molecule seems to cooperate with the other semen antioxidants to protect sperm cells from extracellular oxygen radicals.
authors.affiliation: Unité d'Immunologie Microbienne, Institut Pasteur, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Bouvet
authors.forename: S
authors.initials: S
authors.lastname: D'Azambuja
authors.forename: C
authors.initials: C
authors.lastname: Roux
authors.forename: L
authors.initials: L
authors.lastname: Lebrun
authors.forename: J
authors.initials: J
authors.lastname: Pillot
mesh_terms: D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D012661:Semen / Q000737:chemistry / Q000502:physiology*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D015054:Zymosan