Comparative metabolism of high doses of aspirin in man and rat.
1. Metabolism of aspirin was studied in 10 human volunteers who took a therapeutic dose (600 mg) by mouth and in nine patients who took aspirin in overdose. 2. Salicyluric acid was the major urinary metabolite in volunteers (63.1 +/- 8.4% of dose in 0-8 h). In overdose patients, salicyluric acid in urine was decreased (30.0 +/- 8.2%, 0-24 h, P less than 0.001) and there was increased elimination of salicyclic acid (34.1%, P less than 0.005), salicyl acyl glucuronide (14.4%, P less than 0.05) and gentisuric acid (5.3%). 3. Metabolism of orally administered 14C-aspirin in rats over a 10-fold dose range (10-100 mg/kg) resulted in excretion of 81-91% dose in urine in the first 24 h. Salicyclic acid was the major urinary metabolite (43-51% dose). Excretion of salicyluric acid decreased with increasing dose, whereas gentisic acid and salicyl phenolic and acyl glucuronides increased. 4. The profile of aspirin metabolites was qualitatively similar in man and rat but there were quantitative differences. Limited capacity to form salicyluric acid was observed in both species. Dependence on this pathway in rat was low and was compensated by increased utilization of other routes; dependence on salicyluric acid formation in man was high and in overdose, compensation by other routes was incomplete.
Patel
D K
DK
School of Pharmacy and Pharmacology, University of Bath, UK.
Notarianni
L J
LJ
Bennett
P N
PN
D000293:Adolescent; D000328:Adult; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000506:poisoning; D005260:Female; D005841:Gentisates / Q000652:urine; D005965:Glucuronates / Q000652:urine; D006626:Hippurates / Q000652:urine; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000652:urine; D020156:Salicylic Acid
D005841:Gentisates; D005965:Glucuronates; D006626:Hippurates; D012459:Salicylates; C016471:gentisuric acid; C066070:salicylacyl glucuronide; C000693:salicylurate; D020156:Salicylic Acid; D001241:Aspirin