title: Royal Free Hospital protocol for 24-hour intragastric acidity and plasma gastrin concentration.
abstract: The Royal Free Hospital protocol for simultaneous measurement of 24-hour intragastric acidity and plasma gastrin concentration is described in detail. The methods of analysing such data are discussed, with recommendations for a standard four-way analysis: median hourly 24-hour intragastric acidity or pH, or plasma gastrin concentration; integrated 24-hour intragastric acidity, or plasma gastrin concentration; analysis of integrated values according to meal-related intervals; and quantification of the percentage of time in a 24-hour period that intragastric pH is greater than 3.
authors.affiliation: Academic Department of Medicine, Royal Free Hospital, School of Medicine, London, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
authors.forename: S
authors.initials: S
authors.lastname: Lanzon-Miller
authors.forename: J T
authors.initials: JT
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Gavey
authors.forename: C U
authors.initials: CU
authors.lastname: Nwokolo
authors.forename: E J
authors.initials: EJ
authors.lastname: Prewett
authors.forename: J
authors.initials: J
authors.lastname: Sercombe
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002985:Clinical Protocols; D005502:Food; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007441:Intubation, Gastrointestinal; D008991:Monitoring, Physiologic / Q000379:methods*; D013396:Suction / Q000379:methods*; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D005755:Gastrins