Effectiveness of arprinocid in the reduction of cryptosporidial activity in immunosuppressed rats.
Immunosuppressed rats inoculated with Cryptosporidium oocysts isolated from calves' feces were treated with arprinocid, 50 mg/kg of body weight/d. As determined from differences in the mean number of cryptosporidial developmental stages per villus in treated vs control rats, arprinocid had a substantial effect on cryptosporidial activity, which was parasitistatic instead of parasiticidal. Drug-ranging experiments indicated that arprinocid was effective at 50 and 25 mg/kg/d, but not at 12.5 mg/kg/d. These results suggest that further testing of arprinocid in different animal models, or in phase-I clinical trials, is warranted.
Rehg
J E
JE
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
Hancock
M L
ML
D000225:Adenine / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology; D000818:Animals; D003049:Coccidiostats / Q000276:immunology / Q000494:pharmacology*; D003458:Cryptosporidium / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D005260:Female; D007082:Ileum / Q000469:parasitology*; D007108:Immune Tolerance / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D003049:Coccidiostats; C016245:arprinocid; D000225:Adenine