[The state of the liver in rabbits during combination chemotherapy of experimental disseminated tuberculosis].
Functional and morphologic changes in the liver condition of experimental rabbits were studied in the process of the disseminated tuberculosis development and treatment. Medication of the animals was started 2 weeks after the infection at the peak of the process and continued for 60 days. In Group 1 of the rabbits, isoniazid and rifampicin were administered enterally in combination with intramuscular streptomycin, and in Group 2, isoniazid and rifampicin were given intravenously plus intramuscular streptomycin. The doses of the antibacterial drugs were adequate, as compared to the clinical ones. It was shown that an intravenous administration of isoniazid and rifampicin supplemented by intramuscular streptomycin resulted in more pronounced normalization of processes in the liver morphologic and functional changes caused by tuberculosis than an enteral route of administration of the drugs.
Mozhokina
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GN
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects*; D011817:Rabbits; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy*
D000995:Antitubercular Agents; D013307:Streptomycin
Sostoianie pecheni krolikov pri kompleksnoĭ khimioterapii éksperimental'nogo disseminirovannogo tuberkuleza.