Reactive oxygen and glomerular dysfunction.
1. The function of the kidney glomerulus, and the formation of reactive oxygen species in the glomerulus, is reviewed. 2. Experimental models of glomerular injury, resulting from immunological and non-immune reactions, are known to give rise to morphological and functional changes of the glomerulus, resulting in proteinuria. 3. From the use of oxygen radical scavengers and inhibitors, glomerular injuries have been shown to be associated with the production of hydrogen peroxide, hydroxyl radical, and superoxide anion radical.
Iwasaki
K
K
Department of Pharmacokinetics and Drug Metabolism, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
D000818:Animals; D005609:Free Radicals; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000503:physiopathology; D010101:Oxygen Consumption
D005609:Free Radicals