Unilateral naevoid basal-cell-carcinoma syndrome--an individually controlled study of fibroblast sensitivity to radiation.
A patient with unilateral naevoid basal-cell-carcinoma syndrome (NBCCS, Gorlin's syndrome) provided a unique opportunity to compare the radiation sensitivity of fibroblasts from the affected and unaffected sides of the same individual. Although the growth rate of the fibroblast strain established from the affected side was faster than that from the unaffected side there was no difference in X-ray, UV-B or UV-C radiation sensitivity between fibroblasts from the two sides. These results are discussed in the context of previous studies of radiation sensitivity in NBCCS.
Sharpe
G R
GR
University Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Cox
N H
NH
D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000473:pathology*; D002455:Cell Division / Q000528:radiation effects; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014965:X-Rays