title: Multiple primary malignancies in patients with malignant tumours of the nasal cavities and paranasal sinuses.
abstract: The incidence of multiple primary malignancies (MPM) was analysed in 1297 patients with malignant tumours of the nasal cavities and paranasal sinuses. The patients were followed for a minimum of six years or until death. The incidence of MPM was 3.4 per cent (44/1297) which is lower in patients with malignant tumours of other regions in the upper aerodigestive tract. Five of the 44 patients had second malignancies within previously irradiated areas. There was a difference between the proportion of histologies occurring in irradiated tissues compared with the overall 1297 patients. This finding suggests that radiotherapy may induce a second cancer.
authors.affiliation: Department of Otolaryngology, Kagawa Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyaguchi
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Kitaoku
mesh_terms: D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology* / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects