title: The pharmacokinetics of oxytetracycline following intravenous administration in healthy and diseased pigs.
abstract: The pharmacokinetics of oxytetracycline (OTC) were studied in healthy pigs and in pigs endobronchially inoculated with Actinobacillus pleuropneumoniae toxins. In two groups of seven pigs OTC was administered intravenously in a single dose of 10 or 50 mg/kg, respectively. OTC was administered to clinically healthy pigs and 7 days later at 3 h after a challenge with A. pleuropneumoniae toxins. Pneumonia developed in toxin-treated pigs. In the challenged pigs there was a decreased distribution-rate constant (alpha) and a significantly increased elimination-rate constant (beta) (P less than 0.05). Moreover, the apparent volume of distribution (Vd beta) was decreased. The elimination half-lives (t1/2 beta) were approximately 6 h in the healthy pigs and 5 h in the diseased animals. There was no difference in the pharmacokinetic profile of OTC following administration of 50 mg/kg compared to 10 mg/kg.
authors.affiliation: Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Pijpers
authors.forename: E J
authors.initials: EJ
authors.lastname: Schoevers
authors.forename: H
authors.initials: H
authors.lastname: van Gogh
authors.forename: L A
authors.initials: LA
authors.lastname: van Leengoed
authors.forename: I J
authors.initials: IJ
authors.lastname: Visser
authors.forename: A S
authors.initials: AS
authors.lastname: van Miert
authors.forename: J H
authors.initials: JH
authors.lastname: Verheijden
mesh_terms: D000189:Actinobacillus Infections / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D011014:Pneumonia / Q000378:metabolism / Q000662:veterinary*; D013552:Swine / Q000378:metabolism*; D013553:Swine Diseases / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D010118:Oxytetracycline