[The role of aromatic hydrocarbon hydroxylase in the pathogenesis of lung cancer].
Aromatic hydrocarbons hydroxylase (AHH)--an enzyme of monooxydases group--catalyzes hydroxylation of polycyclic aromatic hydrocarbons yielding compounds of the direct cancerogenic properties. Inducibility determined genetically is a characteristic feature of AHH. Inducibility of AHH in patients with cancer of the lungs is higher than that in healthy population. According to some authors general population may be classified into three groups of : high, moderate, and low degree of AHH inducibility. A significant increase in the incidence of neoplasms related to an exposition to PAH was noted in patients with increased AHH inducibility. These neoplasms include: carcinoma of the lungs, mouth and larynx, cancer of the pharynx and leukoplakia. Moreover, the onset of these neoplasms is earlier than in subjects with moderate and low inducibility of AHH.
Pilarska-Machowicz
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Oddziału Ftizjopneumonologii Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
D000393:Air Pollutants / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced*; D011083:Polycyclic Compounds / Q000009:adverse effects* / Q000493:pharmacokinetics
D000393:Air Pollutants; D011083:Polycyclic Compounds; D001189:Aryl Hydrocarbon Hydroxylases
Rola hydroksylazy weglowodorów aromatycznych w patogenezie raka płuca.