[A new diterpenoid quinone sapriparaquinone].
A new diterpenoid quinone, named sapriparaquinone (1) was isolated from the root of Salvia prionitis Hance. 1 was identified as 3-hydroxy-6-methyl-2-(1-methyl)-5-(4-methylpenten-3-yl)-1, 4-naphthoquinone by spectral analysis and chemical transformation of saprorthquinone (2). 1 and 2 are 4,5-seco-5, 10-frideoabietane derivatives and must be biogenetically derived from an abietane structure. Like 2, 1 also showed cytotoxicity against P388 leukemia cells.
Lin
L Z
LZ
Shangai Institute of Materia Medica, Chinese Academy of Sciences.
Wang
X M
XM
Huang
X L
XL
Huang
Y
Y
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D009285:Naphthoquinones; C066123:sapriparaquinone