Protein oxidation and myelinolysis occur in brain following rapid correction of hyponatremia.
Myelinolysis occurs following rapid correction of hyponatremia in both humans and experimental animals. Although the mechanism of this effect at present is unknown, we have examined the possibility that a rapid rise in serum sodium following hyponatremia potentiates an oxidative stress and results in the oxidation of cellular proteins. In these studies, rats treated with 1 M NaCl following 3 days of vasopressin-induced hyponatremia exhibited myelinolysis in the corpus striatum and thalamus as well as significant increases in soluble oxidized proteins in the brain. These changes did not occur in rats treated with 0.155 M (0.9%) NaCl following 3 days of hyponatremia.
Mickel
H S
HS
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Oliver
C N
CN
Starke-Reed
P E
PE
D000818:Animals; D001127:Arginine Vasopressin; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D007010:Hyponatremia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009186:Myelin Sheath / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*; D014667:Vasopressins
D009419:Nerve Tissue Proteins; C016671:pitressin tannate; D014667:Vasopressins; D001127:Arginine Vasopressin; D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium