title: Comparative study of RIS with the 131I-OC 125 F(ab')2 Mab and CT scan prior to second look operation for ovarian cancer.
abstract: A tumour-associated radiolabelled monoclonal antibody (Mab) 131I-OC 125 F(ab')2 was used to investigate 27 patients 2 weeks after their last chemotherapy regimen and prior to second-look surgery for ovarian cancer. We did compare the radioimmunoscintigraphy (RIS) findings with the CT scan results and the second-look operation data. In 23 out of 27 cases the RIS results correlated with the operation findings, while there were four false-negative results. Computed tomography (CT) scans correlated in 17 out of 23 cases with the operative findings, while there were six false-negative results. We concluded that RIS is more specific in detecting the tumour site within the pelvis, while CT scan is superior in detecting liver metastases.
authors.affiliation: First Department of Obstetrics and Gynecology, University of Athens Alexandra Maternity Hospital, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Papazefkos
authors.forename: S
authors.initials: S
authors.lastname: Michalas
authors.forename: V
authors.initials: V
authors.lastname: Papantoniou
authors.forename: J
authors.initials: J
authors.lastname: Datseris
authors.forename: P
authors.initials: P
authors.lastname: Athanasiadis
authors.forename: T
authors.initials: T
authors.lastname: Akrivos
authors.forename: A
authors.initials: A
authors.lastname: Leonti
authors.forename: A
authors.initials: A
authors.lastname: Xygakis
authors.forename: D
authors.initials: D
authors.lastname: Aravantinos
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012086:Reoperation; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes