title: Testing for fluoxymesterone (Halotestin) administration to man: identification of urinary metabolites by gas chromatography-mass spectrometry.
abstract: Fluoxymesterone, an anabolic steroid, is metabolized in man primarily by 6 beta-hydroxylation, 4-ene-reduction, 3-keto-reduction, and 11-hydroxy-oxidation. These pathways of metabolism are suggested by the positive identification of 4 metabolites and the tentative identification of 3 other metabolites. Detection of the drug in urine is possible for at least 5 days after a single 10 mg oral dose to previously untreated adult males, by monitoring the presence of 2 metabolites, since the parent drug is not detectable more than 1 day after the dose.
authors.affiliation: Paul Ziffren Olympic Analytical Laboratory, UCLA Department of Pharmacology, School of Medicine 90024.
authors.forename: R C
authors.initials: RC
authors.lastname: Kammerer
authors.forename: J L
authors.initials: JL
authors.lastname: Merdink
authors.forename: M
authors.initials: M
authors.lastname: Jagels
authors.forename: D H
authors.initials: DH
authors.lastname: Catlin
authors.forename: K K
authors.initials: KK
authors.lastname: Hui
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005474:Fluoxymesterone / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008954:Models, Biological; D019966:Substance-Related Disorders / Q000652:urine
chemical_list: D005474:Fluoxymesterone