Successful therapy of meningococcal sepsis in acute disseminated lupus erythematosus with plasmapheresis, immunosuppression, and antibiotics.
A 17-year-old female with a 5-year history of disseminated lupus erythematosus has remained without immunosuppressive therapy for the last 3 years. She was admitted to the hospital for acute abdominal pain, generalized edema, and rapidly developing dyspnea and somnolence. Although all symptoms were consistent with active SLE, septicemia was suspected because of leukocytosis (20,000/microliters), greatly elevated C-reactive protein (45 mg/dl), and normal complement values (C3 0.74 g/l, C4 0.21 g/l). Directly after bacterial blood cultures were prepared, a combined treatment was instituted consisting of plasmapheresis (3 x 2.1 l against fresh frozen plasma), antibiotics, prednisolone, and cyclophosphamide following the last plasmapheresis. Within three days cerebral function returned to normal, edema improved, and CRP fell to 0.5 mg/dl. The blood cultures and pericardial effusion displayed meningococcal colonies.
Dobos
G J
GJ
Abteilung für Nephrologie, Universitätsklinik Freiburg.
Meske
S
S
Keller
E
E
Riegel
W
W
Vaith
P
P
Peter
H H
HH
Schollmeyer
P
P
D000293:Adolescent; D002439:Cefotaxime / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008589:Meningococcal Infections / Q000150:complications / Q000628:therapy*; D010490:Pericardial Effusion / Q000209:etiology / Q000628:therapy; D010956:Plasmapheresis; D018805:Sepsis / Q000150:complications / Q000628:therapy*
D007166:Immunosuppressive Agents; D002439:Cefotaxime