title: Retinal toxicity of intravitreal ticarcillin.
abstract: The retinal toxicity of the penicillin derivative, ticarcillin, was tested in albino rabbits by injecting the animals intravitreally with doses ranging from 50 to 3,000 micrograms, and monitoring them for 4 weeks. A second confirmatory study was performed by repeating the high-dose injections in a different set of rabbits and monitoring them for 3 weeks. Histologic examination and electroretinography of both groups showed that dosages up to 3000 micrograms produced no detectable damage to the retina. A dosage of 3000 micrograms of ticarcillin, which is 38 times the minimal inhibitory concentration for Pseudomonas aeruginosa, appears safe.
authors.affiliation: Louisiana State University Medical Center School of Medicine, New Orleans 70112.
authors.forename: T J
authors.initials: TJ
authors.lastname: Heigle
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004596:Electroretinography / Q000187:drug effects; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D013982:Ticarcillin / Q000008:administration & dosage / Q000633:toxicity*; D014822:Vitreous Body
chemical_list: D013982:Ticarcillin