Correlation between beta 2-microglobulin and soluble interleukin-2 receptor levels in plasma of individuals living in a malarial endemic region.
beta 2-Microglobulin (beta 2m) levels were related to the expected immunoprotection in 81 individuals living in a malarial mesoendemic area near Bobo-Dioulasso (Burkina Faso), who were longitudinally followed. Soluble interleukin-2 receptor (sIL-2R) levels were positively correlated to those of beta 2m (r = 0.44; n = 237; P less than 0.001). This suggests that most of the beta 2m could have originated from activated T and B cell membrane turnover. In our study, both beta 2m and sIL-2R were inversely related to IgG antibodies (Ab) against somatic antigen of Plasmodium falciparum (Som-Ag). Therefore, these molecules at high levels could have a down regulating activity, directly or indirectly, on B cells producing this kind of Ab.
Chumpitazi
B F
BF
Département de Parasitologie-Mycologie Médicale et Moléculaire (DP3M), CNRS URA 1344, Faculté de Médecine, Université Joseph Fourier-Grenoble I, La Tronche, France.
Renversez
J C
JC
Peyron
F
F
Boudin
C
C
Picot
S
S
Ambroise-Thomas
P
P
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008137:Longitudinal Studies; D008288:Malaria / Q000097:blood* / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D001613:beta 2-Microglobulin / Q000032:analysis*
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D015375:Receptors, Interleukin-2; D001613:beta 2-Microglobulin