title: International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 7/1/3. Animal studies suggesting involvement of mutagen/carcinogen exposure in atherosclerosis.
abstract: It is very important to elucidate the causative agents of atherosclerosis because coronary heart disease and cerebrovascular disease are the main causes of death in the developed countries. The evidence for a monoclonal origin of atherosclerotic plaques in humans prompted the study of the involvement of mutagens/carcinogens in the development of atherosclerosis. Polycyclic hydrocarbons, including 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene, were shown to act as initiators and/or accelerators in atherosclerotic plaque formation in the chicken, pigeon and mouse. Radiation and oxygen radicals were also demonstrated to be involved in the development of atherosclerosis in animals.
authors.affiliation: Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
mesh_terms: D000588:Amines / Q000009:adverse effects; D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced*; D002273:Carcinogens / Q000494:pharmacology*; D002645:Chickens; D010856:Columbidae; D006571:Heterocyclic Compounds / Q000009:adverse effects; D008297:Male; D051379:Mice; D009153:Mutagens / Q000009:adverse effects*; D011083:Polycyclic Compounds / Q000009:adverse effects; D011817:Rabbits; D011832:Radiation Injuries; D051381:Rats
chemical_list: D000588:Amines; D002273:Carcinogens; D006571:Heterocyclic Compounds; D009153:Mutagens; D011083:Polycyclic Compounds