title: [The possibilities for enhancing the immunogenicity of adenovirus hexon].
abstract: Synthetic polyelectrolytes and muramyldipeptide derivatives are tested as immunostimulators. It is established that the level of antibody-forming cells and specific (virus-neutralizing and precipitating) antibodies considerably rises during the immunization of human adenovirus I hexon in the combination with N-acetylglucosaminyl-muramyldipeptide and conjugation with a copolymer including acrylic acid and N-vinylpyrrolidone. A more expressed intensification of the antibody-formation is observed with the use of polyelectrolytes.
authors.forename: L A
authors.initials: LA
authors.lastname: Tarasishin
authors.forename: N S
authors.initials: NS
authors.lastname: Diachenko
authors.forename: A V
authors.initials: AV
authors.lastname: Nekrasov
authors.forename: S V
authors.initials: SV
authors.lastname: Lel'chuk
authors.forename: T M
authors.initials: TM
authors.lastname: Andronova
mesh_terms: D000260:Adenoviruses, Human / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002213:Capsid / Q000276:immunology* / Q000302:isolation & purification; D036022:Capsid Proteins; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus
vernacular_title: Vozmozhnosti povysheniia immunogennosti geksona adenovirusov.