Sequence-dependent formation of alkyl DNA adducts: a review of methods, results, and biological correlates.
Understanding the influence of the DNA sequence on chemical-DNA interactions may provide insight into the processes of chemical carcinogenesis and mutagenesis. This article provides a brief overview of studies and methods devoted to examining the distribution of DNA adducts produced by alkylating agents. Particular emphasis is placed on discussion of DNA adducts generated by simple alkylating agents and the role that their distribution may play in the generation of mutational hotspots.
Richardson
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Lilly Research Laboratories, Eli Lilly and Co., Greenfield, IN 46140.
Richardson
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D000477:Alkylating Agents / Q000378:metabolism / Q000494:pharmacology*; D000478:Alkylation; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage; D008969:Molecular Sequence Data; D009154:Mutation
D000477:Alkylating Agents; D004247:DNA