title: Short- and long-term effects of azadirachtin A on development and egg production of Rhodnius prolixus.
abstract: Azadirachtin A was given through a blood meal to 4th-instar larvae and to adult females of Rhodnius prolixus. Development (ecdysis) and egg production were inhibited in a dose-dependent manner. Long-term experiments with subsequent four feedings on azadirachtin-free blood were performed with 4th-instar larvae and with adult females. Only in the low-dose azadirachtin larval groups (0.01 and 0.1 microgram/ml of blood), development was partially restored; after a single 1.0 microgram/ml treatment about 50% of the treated larvae were still alive 120 days later without any adult emergence. Similarly fed females had a dose-dependent lower survival and egg deposition rate. The results are discussed in relation to the mode of azadirachtin A action.
authors.affiliation: Instituto Oswaldo Cruz, Departamento de Bioquímica e Biologia Molecular, Rio de Janeiro, Brasil.
authors.forename: E S
authors.initials: ES
authors.lastname: Garcia
authors.forename: D
authors.initials: D
authors.lastname: Feder
authors.forename: J E
authors.initials: JE
authors.lastname: Gomes
authors.forename: H
authors.initials: H
authors.lastname: Rembold
mesh_terms: D000818:Animals; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D036701:Limonins; D010058:Oviposition / Q000187:drug effects*; D012239:Rhodnius / Q000502:physiology*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D036701:Limonins; D014315:Triterpenes; C010329:azadirachtin