Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes.
We could demonstrate that polyenzyme preparations as well as bromelain and papain stimulate the production of tumor necrosis factor-alpha in human peripheral-blood mononuclear cell cultures in a time-dependent manner. We give evidence that immunomodulation and especially the release of cytokines may contribute to the therapeutic effect of these preparations.
Desser
L
L
Institute of Experimental and Applied Oncology, University of Vienna, Austria.
Rehberger
A
A
D000911:Antibodies, Monoclonal; D001963:Bromelains / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D006867:Hydrolases / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008233:Lymphotoxin-alpha / Q000032:analysis; D010206:Papain / Q000494:pharmacology*; D012431:Rutin / Q000494:pharmacology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000911:Antibodies, Monoclonal; D004338:Drug Combinations; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; D012431:Rutin; C023295:Wobenzym; D001963:Bromelains; D006867:Hydrolases; D010206:Papain