[Inhibition of the angiotensin-converting enzyme from bovine kidney by organophosphorus analogs of amino acids].
Reactions of amino acid phosphoorganic derivatives with angiotensin-converting enzyme (dipeptidyl carboxypeptidase) were studied. Substitution of the amino acid carboxyl group by HS- or P(O) (OH)2-groups did not cause the enzyme considerable inhibition. The enzymatic activity was inhibited by 20-50% in presence of 1 X 10(-3) M Asp, Met and Cys phosphoorganic derivatives. These amino acid derivatives may be used as potential antihypertensive drugs because of their metabolic stability and inhibitory action on the enzyme.
Shumiantseva
V V
VV
Gandurina
I A
IA
Osipova
T I
TI
Kugaevskaia
E V
EV
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry; D002417:Cattle; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000596:Amino Acids; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D009943:Organophosphorus Compounds
Ingibirovanie angiotenzinprevrashchaiushchego fermenta iz pochek byka fosfororganicheskimo analogami aminokislot.