Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats.
1. p-Hydroxymephentermine (p-hydroxy-MP) and p-hydroxyphentermine (p-hydroxy-Ph) were isolated as hydrochlorides from urine of male Wistar rats repeatedly dosed with mephentermine (MP). In addition, p-hydroxy-Ph was isolated as the hydrochloride from urine of the rats dosed with phentermine (Ph). 2. These results substantiate previous indications that p-hydroxylation of MP and Ph was a primary metabolic reaction in the rat.
Mori
M A
MA
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Uy-Yu
N
N
Sakai
K
K
Inoue
M
M
Miyahara
T
T
Kozuka
H
H
D000814:Aniline Compounds / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008616:Mephentermine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000652:urine*; D010645:Phentermine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D000814:Aniline Compounds; C066111:4-hydroxymephentermine; C066212:2-fluoroaniline; C066112:4-hydroxyphentermine; D010645:Phentermine; D008616:Mephentermine