Interaction of cimetidine with human serum albumin.
Ultrafiltration studies have detected the existence of a weak interaction between cimetidine and human serum albumin, a finding supported by corresponding studies with this xenobiotic and bovine serum albumin. Furthermore, the binding characteristics of the interaction with human serum albumin (4 sites, K = 630 M-1) more than suffice to account for the proportion of protein-bound drug in the serum of patients subjected to cimetidine therapy. Thus, although alpha 1-acid glycoprotein is usually regarded as the specific transporter of basic drugs, the present evidence implicates albumin as the likely binding protein for cimetidine in serum.
Wilson
C J
CJ
Department of Biochemistry, University of Queensland, St Lucia, Australia.
Bogoyevitch
M A
MA
Winzor
D J
DJ
D001665:Binding Sites; D002021:Buffers; D002927:Cimetidine / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D014462:Ultrafiltration
D002021:Buffers; D012709:Serum Albumin; D002927:Cimetidine