[Effects of trophoblastic beta 1-glycoprotein (TBG) on the functional activity of different cell lines].
The effect of TBG on the functional activity of different cell lines, spontaneous and Con A induced proliferation of PBL was studied. If concentration of TBG is higher than 50 mu kg/ml it suppresses the proliferation in many used cell lines, except choriocarcinoma and cancer of uterus. The reliable increasing of spontaneous proliferation of PBL, Jurkat and K-562 cells may be observed if concentration is more lower (0.5-15 mu kg/ml). However proliferation of other cell lines corresponds to control level, and Con A induced proliferation of PBL is inhibited. The effect was more marked at 48, as compared to 24 hours of cell incubation with TBG.
Liakhov
V V
VV
Gudima
S O
SO
Terekhov
O P
OP
Sokolov
A V
AV
Vengerov
Iu Iu
IuIu
Sukhikh
G T
GT
D014408:Biomarkers, Tumor / Q000494:pharmacology / Q000502:physiology*; D002455:Cell Division; D002460:Cell Line / Q000187:drug effects / Q000502:physiology; D002822:Choriocarcinoma; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006367:HeLa Cells; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D007951:Leukemia, Myeloid; D015458:Leukemia, T-Cell; D008214:Lymphocytes / Q000166:cytology; D016393:Lymphoma, B-Cell; D016399:Lymphoma, T-Cell; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000494:pharmacology / Q000502:physiology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000502:physiology; D014594:Uterine Neoplasms
D014408:Biomarkers, Tumor; D011268:Pregnancy-Specific beta 1-Glycoproteins; D003208:Concanavalin A
Vliianie trofoblasticheskogo beta 1-glikoproteina (TBG) na funktsional'nuiu aktivnost' razlichnykh kletochnykh liniĭ.