Endothelin-like immunoreactivity in human breast cyst fluid.
Immunoreactive endothelin has been detected in 21 of 43 samples of breast cyst fluid (21 cases; 3.5 +/- 0.6 pmol/l, mean +/- SEM. Other 22 cases; not detectable, less than 0.5 pmol/l). Fast protein liquid chromatographic analysis of the immunoreactive endothelin of pooled breast cyst fluid showed two immunoreactive peaks; one in the void volume and the other in the position of endothelin-1. It is probable that endothelin-1 is produced by the epithelial cells lining breast cysts, but significance of the presence of endothelin-1 in breast cyst fluid remains to be elucidated.
Takahashi
K
K
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Lai
L C
LC
Ghatei
M A
MA
James
V H
VH
Bloom
S R
SR
D002851:Chromatography, High Pressure Liquid; D016232:Endothelins / Q000032:analysis*; D005122:Exudates and Transudates / Q000737:chemistry*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry*; D006801:Humans; D011863:Radioimmunoassay
D016232:Endothelins