[The proliferative kinetics and acid-soluble proteins of the nuclear chromatin in tumor cells with a modified polyamine level].
The inhibition of polyamine synthesis by DFMO (2.7 x 10(-3) M) resulted in a decrease of proliferation rate of L and OH-1 cells. The patterns of acid-soluble nuclear proteins were studied by the SDS electrophoresis. The content of protein fraction with molecular weight 25 kD was shown to correlate with the rate of proliferation of cell cultures.
Negreĭ
G Z
GZ
Ianish
Iu V
IuV
Zavelevich
M P
MP
Shliakhovenko
V A
VA
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000737:chemistry / Q000187:drug effects*; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects*; D000518:Eflornithine / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D007739:L Cells; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis / Q000187:drug effects*; D011073:Polyamines / Q000037:antagonists & inhibitors*; D012995:Solubility; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D002843:Chromatin; D009363:Neoplasm Proteins; D011073:Polyamines; D000518:Eflornithine
Kinetika proliferatsii i kislotorastvorimye belki iadernogo khromatina opukholevykh kletok pri modifitsirovannom urovne poliaminov.