title: The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives.
abstract: Pseudolaric acid-A and -B, the novel diterpene acids isolated from Pseudolarix kaempferi, and their related derivatives have been tested for cytotoxicity against KB, A-549, HCT-8, P-388, and L-1210 tumor cells. The results showed that pseudolaric acid-A and -B demonstrated potent cytotoxicity. The selectivity of pseudolaric acid-A and -B which inhibit the growth of particular cell types within the disease-oriented human cancer cell line panels is discussed.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
authors.forename: D J
authors.initials: DJ
authors.lastname: Pan
authors.forename: Z L
authors.initials: ZL
authors.lastname: Li
authors.forename: C Q
authors.initials: CQ
authors.lastname: Hu
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C058391:pseudolaric acid B; C058390:pseudolaric acid A