[Triclabendazole (Fasinex) residue in milk: determination and excretion kinetics].
The determination of triclabendazole (Fasinex) in milk is described. The excretion of triclabendazole and its two main metabolites was measured under field conditions in twenty-five cows. Triclabendazole was administered to cows in a dosage of approximately 12 mg kg-1. The maximum concentration of the main metabolites of triclabendazole (triclabendzole sulphone) measured in milk was 1.415 mg/l. Metabolites could be detected in milk during a ten-day-period. Only 1.5% (maximum) of the triclabendazole administered was eliminated as triclabendazole sulphone by way of milk.
Counotte
G H
GH
Gezondheidsdienst voor Dieren in Overijssel en Flevoland, Zwolle.
Reimink
A
A
Redder
B
B
Hasselt
H
H
D000818:Animals; D000871:Anthelmintics / Q000032:analysis*; D001562:Benzimidazoles / Q000032:analysis* / Q000493:pharmacokinetics / Q000652:urine; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D008892:Milk / Q000737:chemistry*; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole
Triclabendazol (Fasinex)-residuen in melk: bepaling en uitscheidingskinetiek.