[Activity of cytochrome P450 in the stomach, with special reference to postoperative survival rate of patients with gastric cancer treated by tegafur].
In routine histological preparation of gastric wall and liver specimens, immunohistochemical study of P450 was performed in the total of 116 absolutely noncurative resection of gastric cancer which followed by postoperative administration of tegafur. P450 in the liver, which considered to play a main role of tegafur activation, was strongly stained and correlated well with that of the stomach. Divided the cases into 3 groups from the degree of immunohistochemical staining of P450, postoperative survival was significantly correlated with the intensity of staining in the stomach. And the more the stage of gastric cancer advanced, the less the tissue P450 was stained. From the results obtained, reasonable consecutive administration of tegafur would be possible by immunohistochemical checking the P450 in the gastric wall.
Watanabe
H
H
Division of Abdominal Surgery, Saitama Cancer Center Hospital.
Suda
Y
Y
D003131:Combined Modality Therapy; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000201:enzymology; D011182:Postoperative Care; D013270:Stomach / Q000201:enzymology*; D013274:Stomach Neoplasms / Q000201:enzymology / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate; D005641:Tegafur / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000201:enzymology
D005641:Tegafur; D003577:Cytochrome P-450 Enzyme System