title: Surgery in patients on long-term steroid therapy: a tentative model for risk assessment.
abstract: Increased morbidity after operation has been associated with long-term steroid therapy. To determine the correlation between steroid therapy and such morbidity, the perioperative course of 55 steroid-treated patients was reviewed: 27 had bronchopulmonary disorders (group P) and 28 had non-pulmonary diseases (group NP). There were six (11 per cent) deaths, of which three were steroid related. Among the 13 non-lethal postoperative complications, eight were considered to be steroid related in group P and one in group NP. The duration of steroid therapy was for a median of 24 months (range 1-408 months) in group P and for a median of 6 months (range 1-240 months) in group NP (P less than 0.01). In contrast, the daily dose of hydrocortisone or equivalent before operation was significantly lower in group P, with a median of 0.51 mg kg-1 day-1 (range 0.20-2.56 mg kg-1 day-1) than in group NP, with a median of 1.20 mg kg-1 day-1 (range 0.23-7.38 mg kg-1 day-1) (P less than 0.01). In conclusion, bronchopulmonary disorders requiring a long duration of steroid therapy are associated with a higher risk of steroid-related complications after surgery. A convenient mathematical model is proposed which may allow a preoperative assessment of surgical risk, using steroid dose and duration of treatment.
authors.affiliation: Surgical Service, Mont-Godinne University Hospital, University of Louvain Medical School, Yvoir, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Reding
authors.forename: L A
authors.initials: LA
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Donckier
authors.forename: L
authors.initials: L
authors.lastname: de Canniere
authors.forename: J
authors.initials: J
authors.lastname: Jamart
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D011183:Postoperative Complications / Q000209:etiology; D012307:Risk Factors; D013256:Steroids / Q000008:administration & dosage / Q000009:adverse effects*; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D013256:Steroids; D006854:Hydrocortisone