title: IgE-positive epidermal Langerhans cells in allergic contact dermatitis lesions provoked in patients with atopic dermatitis.
abstract: To see whether or not IgE-bearing epidermal Langerhans cells are specific to skin lesions of atopic dermatitis (AD), we performed immunohistochemical and immunoelectron microscopic examinations of dinitro-chlorobenzene (DNCB) contact dermatitis lesions provoked in uninvolved skin of eight patients with AD. In all of the eight examined, IgE-positive epidermal Langerhans cells were observed in the DNCB dermatitis lesions. Typical staining of anti-IgE was absent in the epidermis of normal-appearing skin of five patients with AD. Thus, it is likely that IgE positive epidermal Langerhans cells non-specifically occur in different eczematous diseases provoked in patients with AD.
authors.affiliation: Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000150:complications*; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D004137:Dinitrochlorobenzene; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D016253:Microscopy, Immunoelectron
chemical_list: D004137:Dinitrochlorobenzene; D007073:Immunoglobulin E