title: Chromosome abnormalities in human epithelial ovarian malignancies.
abstract: Karyotypic analysis of tumor specimens from 29 patients with untreated epithelial ovarian carcinoma was performed at the University of Kentucky Medical Center. Twenty-three of the twenty-nine tumors had adequate cells for analysis. Seventeen of these tumors exhibited chromosome abnormalities. Chromosome alterations were complex, with an average of seven different abnormal chromosomal patterns per tumor (range 2-14). Chromosomes 1 and 11 were the most commonly involved, being abnormal in 89 and 83% of tumors, respectively. Chromosomes 3 and 7 were also frequently abnormal. In contrast to invasive tumors, alterations in chromosomes 1 and 11 were not seen in the two tumors of borderline malignant potential. Evidence for DNA amplification of IGF2, Ha-ras-1, and c-ets was not observed. Amplification of the c-erbB-2 oncogene was present in two tumors. These findings indicate that multiple karyotypic abnormalities occur in untreated epithelial ovarian malignancies, with chromosomes 1 and 11 being the most frequently abnormal. These data also suggest that alterations of these chromosomes may be associated with the biologically aggressive behavior of frankly invasive ovarian tumors.
authors.affiliation: Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536.
authors.forename: H H
authors.initials: HH
authors.lastname: Gallion
authors.forename: D E
authors.initials: DE
authors.lastname: Powell
authors.forename: L W
authors.initials: LW
authors.lastname: Smith
authors.forename: J K
authors.initials: JK
authors.lastname: Morrow
authors.forename: A W
authors.initials: AW
authors.lastname: Martin
authors.forename: J R
authors.initials: JR
authors.lastname: van Nagell
authors.forename: E S
authors.initials: ES
authors.lastname: Donaldson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D066246:ErbB Receptors; D005260:Female; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D007621:Karyotyping; D008875:Middle Aged; D005810:Multigene Family; D010051:Ovarian Neoplasms / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors
chemical_list: D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors; D007335:Insulin-Like Growth Factor II; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases