Stereospecific inhibition of non-opioid defeat analgesia in male mice by MDL 72832, a selective 5-HT1A receptor agonist.
The effects of MDL 72832, a potent and stereoselective ligand for 5-HT1A sites, on basal nociception and non-opioid defeat analgesia in male mice were examined. Neither (+)- nor (-)-MDL 72832 significantly altered basal tail-flick latencies. In contrast, (-)-MDL 72832 potently inhibited defeat analgesia (0.1-0.5 mg/kg i.p.), with similar effects produced by (+)-MDL 72832 only at substantially higher doses (3.0-5.0 mg/kg i.p.). These data clearly demonstrate a stereoselective action of this 5-HT1A ligand on non-opioid defeat analgesia.
Rodgers
R J
RJ
Department of Psychology, University of Leeds, U.K.
Shepherd
J K
JK
D000698:Analgesia; D000818:Animals; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011930:Reaction Time / Q000187:drug effects; D011985:Receptors, Serotonin / Q000378:metabolism; D012919:Social Behavior; D013141:Spiro Compounds / Q000494:pharmacology*; D013237:Stereoisomerism
D011985:Receptors, Serotonin; D013141:Spiro Compounds; C056635:MDL 72832