Followup of adolescents initially treated for prepubertal-onset major depressive disorder with imipramine.
This preliminary followup of adolescents (n = 16) with prepubertal-onset major depressive disorder (MDD) suggests that a significant number continue to be depressed or possibly depressed (62%) and have moderate to severe ongoing psychosocial adjustment problems. A concomitant diagnosis of conduct or oppositional disorder at index assessment was a risk factor for an increased incidence of interim depressive episodes and more severe psychosocial adjustment problems including alcohol and drug abuse.
Hughes
C W
CW
Psychiatric Research Institute, St. Francis Regional Medical Center, Wichita, KS.
Preskorn
S H
SH
Wrona
M
M
Hassanein
R
R
Tucker
S
S
D000293:Adolescent; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male
D007099:Imipramine