[Acetylsalicylic acid in the prevention of arterial thrombosis. Dosage problems in general and in the authors' experiment].
Acetylsalicylic acid is now accepted as a clinically useful drug for secondary prophylaxis against several thromboembolic complications, but there is still much controversy about the dosage. We discuss this problem, in the light of data from newly published clinical trials and of results from a pharmacological study performed by ourselves. All in all it seems reasonable to recommend 100-150 mg acetylsalicylic acid per day for prophylaxis after acute myocardial infarction. As for cerebrovascular indications, no clinical data available so far justify a dose reduction below 300 mg.
Stormorken
H
H
Rikshospitalet, Oslo.
Berg
K J
KJ
Bratvedt
A
A
Nygaard
B
B
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000517:prevention & control*
D001241:Aspirin
Acetylsalisylsyre ved arteriell tromboseprofylakse. Doseringsproblemet generelt og belyst ved eget forsøk.