title: Multimodal imaging in Alzheimer's disease. The relationship between MRI, SPECT, cognitive and pathological changes.
abstract: Patients with a clinical diagnosis of Alzheimer's disease were studied using MRI, SPECT, and psychometric tests. Significant correlations between focal perfusion deficits and focal cognitive deficits were found. Significant correlations between regional relaxation time of white matter and psychometric tests of diffuse and focal categories were also found. Pathological examination confirmed Alzheimer's disease as the only diagnosis.
authors.affiliation: Department of Mental Health, University of Aberdeen, Foresterhill.
authors.forename: J A
authors.initials: JA
authors.lastname: Besson
authors.forename: J R
authors.initials: JR
authors.lastname: Crawford
authors.forename: D M
authors.initials: DM
authors.lastname: Parker
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
authors.forename: P V
authors.initials: PV
authors.lastname: Best
authors.forename: H G
authors.initials: HG
authors.lastname: Gemmell
authors.forename: P F
authors.initials: PF
authors.lastname: Sharp
authors.forename: F W
authors.initials: FW
authors.lastname: Smith
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D000662:Amphetamines; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D010091:Oximes; D011594:Psychometrics; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D015609:Organotechnetium Compounds; D010091:Oximes; C041336:4-iodoamphetamine; D019690:Technetium Tc 99m Exametazime