[Preliminary experiences with chemotactic activity of CGRP using the skin window test].
The neuropeptide CGRP (Calcitonin Gene-Related Peptide) develops in sensory fibers of the human skin a series of well proven biological effects and seems particularly correlated with the neurogenic inflammation. In the site of intradermic injection of 50 pmol of CGRP, neutrophilic inflammation was documented. For this reason we have studied using the skin window test the chemotactic actions of this neuropeptide in vivo. The apposition of CGRP (12.5 pmol) on the abraded skin modifies neutrophilic egress, increasing that effect in a significant way in comparison with controls. The action on neutrophils of CGRP helps to explain the importance of this neuropeptide in the genesis of the "Neurogenic inflammation".
Cappugi
P
P
Clinica Dermosifilopatica I, Università di Firenze.
Gerini
G
G
Verrone
C
C
Velluzzi
M
M
Del Sere
F
F
Tsampau
D
D
Petrini
N
N
Fabbri
P
P
D015740:Calcitonin Gene-Related Peptide; D002634:Chemotaxis, Leukocyte; D006801:Humans; D009504:Neutrophils; D012884:Skin Window Technique; D013997:Time Factors
D015740:Calcitonin Gene-Related Peptide
Esperienze preliminari sull'attività chemiotattica del CGRP con lo skin window test.