Effect of small bowel resection on fecal bile acid excretion and on experimental colon tumour in rats.
Ileal and jejunal resections were carried out to investigate their effect on the faecal bile acid excretion and on the development of 1,2-dimethylhydrazine (DMH)-induced colonic cancer in rats. Both resection types raise the total daily faecal bile acid level compared to the control sham-operated group, whereas ileal resection has a more pronounced effect. The incidence of tumours was found higher in groups with enhanced faecal bile acid level. Our findings show a connection between the daily faecal bile acid excretion and the incidence of DMH-induced colonic cancer.
Morvay
K
K
2nd Department of Surgery, Semmelweis University Medical School, Budapest, Hungary.
Szentléleki
K
K
Török
G
G
Pintér
A
A
D019813:1,2-Dimethylhydrazine; D000714:Anastomosis, Surgical; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism* / Q000502:physiology; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000503:physiopathology*; D004127:Dimethylhydrazines; D005243:Feces / Q000737:chemistry*; D007082:Ileum / Q000601:surgery; D007421:Intestine, Small / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D002273:Carcinogens; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine