Studies on the antineoplasticity of Schiff bases containing 5-nitrofuran and pyrimidine.
Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the compounds are potential antineoplastic agents. However, 2-(5-nitro-2-furfurylidene-amino)-pyrimidine (SBP1) is the most effective, and 2-(5-nitro-2-furfurylidene-amino)-6-hydroxypyrimidine (SBP3) is the least effective agent. Doubling time, rates of protein and DNA synthesis inhibition and LD50 values-1,000 mg/kg body weight for SBP1 and 1,275 mg/kg body weight for 2-(5-nitro-2-furfurylidene-amino)-4- methylpyrimidine (SBP2)- in the oral route support the activity and use of SBP1 and SBP2 as future anticancer agents.
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Department of Chemistry, Jadavpur University, Calcutta, India.
Chatterjee
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Maity
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Roychoudhury
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004354:Drug Screening Assays, Antitumor; D007700:Kinetics; D007940:Leukemia L5178; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009581:Nitrofurans / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D009581:Nitrofurans; D011725:Pyridines