[Does the calcium antagonist verapamil modify calcium metabolism?].
In 11 healthy volunteers the effects of oral verapamil administration (4 X 80 mg/d) on plasma or serum concentrations of ionized, pH-corrected ionized and total calcium, on intact and midregional parathyroid hormone and on 24 h urinary excretion of calcium were investigated at rest. In addition the concentrations of ionized, pH-corrected ionized and total serum calcium were analyzed under bicycle exercise. Verapamil resulted in an increase of total serum calcium (p less than 0.02) and a fall in midregional parathyroid hormone concentrations (p less than 0.02) at rest. There was also found a statistically significant elevation of both ionized (p less than 0.05) and pH-corrected ionized (p less than 0.05) plasma calcium, and a slight increase in the total calcium under exercise (p less than 0.1). Before verapamil a significant negative correlation between total calcium and midregional parathyroid hormone was evident (r = -0.618; p less than 0.05), which however could not be clearly discerned after verapamil.
Scholz
G
G
Abteilung Endokrinologie/Stoffwechselerkrankungen, Bereiches Medizin der Karl-Marx-Universität Leipzig.
Marek
H
H
Grossmann
K D
KD
Kellner
K
K
D000328:Adult; D002118:Calcium / Q000097:blood* / Q000652:urine; D005080:Exercise Test; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D014700:Verapamil / Q000494:pharmacology*
D007477:Ions; D010281:Parathyroid Hormone; D014700:Verapamil; D002118:Calcium
Beeinflusst der Calciumantagonist Verapamil den Calciumhaushalt?