title: [The question of the transmissibility of the results of subcutaneous tests of biomaterials from animals to humans].
abstract: The histologic estimation of the subcutaneous connective-tissue reaction at implants forms an important part of the biocompatibility test. The connective-tissue capsulae around titanium implants in man, guinea-pig, and Wistar-rat were analysed by a special test system because of the question concerning the transmission of results of animal experiments on the man. The subsidence process of the thickness of the connective-tissue capsule and of the cell count per measuring fields were represented in dependence on the time. The findings showed the fundamental similar course of wound healing in man, guinea-pig, and Wistar-rat by the influence of an implant.
authors.affiliation: Institut für Gerichtliche Medizin, Bezirkskrankenhaus Gera, DDR.
authors.forename: H
authors.initials: H
authors.lastname: Schreiber
authors.forename: F
authors.initials: F
authors.lastname: Keller
authors.forename: H P
authors.initials: HP
authors.lastname: Kinzl
authors.forename: H
authors.initials: H
authors.lastname: Hunger
authors.forename: W
authors.initials: W
authors.lastname: Knöfler
authors.forename: U
authors.initials: U
authors.lastname: Rübling
authors.forename: W
authors.initials: W
authors.lastname: Merten
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D002452:Cell Count; D003238:Connective Tissue / Q000473:pathology*; D005549:Foreign-Body Reaction / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D008422:Materials Testing; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D014025:Titanium / Q000009:adverse effects*
chemical_list: D001672:Biocompatible Materials; D014025:Titanium
vernacular_title: Zur Frage der Ubertragbarkeit der Ergebnisse des Subkutantestes von Biomaterialien vom Tier auf den Menschen.