title: Expression of ras gene family as result of compensatory renal growth in mice.
abstract: We have examined several gene expressions during the process of compensatory renal growth in mice following unilateral nephrectomy. On the 3rd, 5th and 7th days after operation in young mice (age: 5w), unilateral nephrectomy induced weight gain of the remaining kidney, but not in adults (age: 15w). It also induced maximum expression of c-H-ras and c-K-ras on the 3rd day in both young and adult mice, but there was no increase in N-ras in either. The expression levels of c-H-ras and c-K-ras were higher in young mice than in adults. However no expression of c-myc was detected at any point. Expression of metallothionein-I (MT-I) gene was detected during the first 12 h after unilateral nephrectomy both in the liver and the contralateral kidney. These data suggest that c-H-ras and c-K-ras gene expressions are in some way related to compensatory renal growth in mice and may be strongly related to hyperplasia in the contralateral kidney.
authors.affiliation: Department of Urology, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nomata
authors.forename: H
authors.initials: H
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Kanetake
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000818:Animals; D015342:DNA Probes; D015870:Gene Expression / Q000502:physiology*; D011905:Genes, ras / Q000235:genetics*; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology*; D008297:Male; D051379:Mice; D009392:Nephrectomy; D009929:Organ Size; D012333:RNA, Messenger / Q000032:analysis; D013997:Time Factors
chemical_list: D015342:DNA Probes; D012333:RNA, Messenger