title: Barium sulphate-loaded p(HEMA) microspheres as artificial emboli: preparation and properties.
abstract: Poly(2-hydroxyethyl methacrylate) p(HEMA) microspheres of good spherical geometry (diameter 90-1500 microns) encapsulated with 40-50% barium sulphate to impart radiopaque properties were prepared by a solvent evaporation process. These microspheres were cross-linked by reacting with hexamethylene diisocyanate (HMDI) or by gamma-irradiation in the presence of ethylene glycol dimethacrylate (EGDM) in n-heptane. Microspheres with a porous structure and a rough surface were also made by the incorporation of NaCl along with BaSO4. The effects of concentration of the polymer solution, concentration of the stabilizing agent, concentration of BaSO4, viscosity of the dispersion medium and ratio of the dispersed phase to the dispersion medium on the formation, stability and particle size distribution of the microspheres were investigated.
authors.affiliation: Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond, Trivandrum, India.
authors.forename: B C
authors.initials: BC
authors.lastname: Thanoo
authors.forename: A
authors.initials: A
authors.lastname: Jayakrishnan
mesh_terms: D001466:Barium Sulfate / Q000737:chemistry; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003485:Cyanates / Q000737:chemistry; D004621:Embolization, Therapeutic / Q000379:methods*; D017953:Isocyanates; D008689:Methacrylates / Q000737:chemistry; D008863:Microspheres; D008954:Models, Biological; D010316:Particle Size; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003485:Cyanates; D017953:Isocyanates; D008689:Methacrylates; C015262:1,6-hexamethylene diisocyanate; D001466:Barium Sulfate; C005044:hydroxyethyl methacrylate; C004919:ethylene dimethacrylate