Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities.
We studied linoleic acid delta 5 and dihomo-gamma-linolenic acid delta 5 desaturations, and fatty acid composition, of liver microsomes in the insulin-dependent spontaneously diabetic adult female BB rat. These desaturations were defective along the normo- and hyper-glycemic period and restored during the hypoglycemic period which followed the insulin injection to the diabetic rats. The fatty acid composition of BB rats microsomes was not consistent with the desaturase activities at the different periods of glycemia, probably because other factors than desaturation impairments were involved in the evolution of fatty acid composition.
Mimouni
V
V
Laboratoire de Physiologie Animale et de la Nutrition, Faculté des Sciences Mirande, Dijon, France.
Poisson
J P
JP
D015126:8,11,14-Eicosatrienoic Acid / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D000090943:Delta-5 Fatty Acid Desaturase; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000502:physiology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D050602:Linoleoyl-CoA Desaturase; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000090943:Delta-5 Fatty Acid Desaturase; D007328:Insulin; D008041:Linoleic Acids; D019787:Linoleic Acid; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase; D015126:8,11,14-Eicosatrienoic Acid