title: [Initial experiences in diagnosis of graft rejection following clinical heart transplantation. Detection of graft-directed activated T-cells].
abstract: The binding of antigen-loaded carrier to mononuclear cells of heart transplant recipients has been investigated by means of an antigen-specific rosette technique. The increase of rosette forming cells and the inhibition of this reaction with monoclonal antibodies against activated T-cells is a sign of a beginning rejection. 3-6 days later infiltrating immunological competent cells are seen in biopsy.
authors.affiliation: Klinik für Chirurgie, Bereich Immunologie der Sektion Biowissenschaften, Karl-Marx-Universität Leipzig.
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: U
authors.initials: U
authors.lastname: Otto
authors.forename: R
authors.initials: R
authors.lastname: Keitel
authors.forename: B
authors.initials: B
authors.lastname: Klötzer
authors.forename: K D
authors.initials: KD
authors.lastname: Schürer
authors.forename: J
authors.initials: J
authors.lastname: Walther
authors.forename: S
authors.initials: S
authors.lastname: Vogt
authors.forename: H
authors.initials: H
authors.lastname: Ambrosius
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD
vernacular_title: Erste Erfahrungen zur Abstossungsdiagnostik nach klinischer Herztransplantation. Der Nachweis transplantatgerichteter aktivierter T-Zellen.