title: Cerebral blood-flow velocity patterns in post-hemorrhagic ventricular dilation.
abstract: To evaluate the effect of ventricular dilation (VD) on cerebral hemodynamics, serial cerebral bloodflow velocity patterns from the anterior and middle cerebral, and circle of Willis arteries were examined by range-gated, pulsed Doppler sonography in premature infants developing post-hemorrhagic VD. Nine infants (25 to 30 weeks gestation) without a patent ductus arteriosus were studied until resolution of VD. Forty-nine cranial sonograms from all nine infants were reviewed independently and grouped cross-sectionally into mild, moderate and severe VD prior to shunt. The corresponding pulsatility index (PI) showed a consistent trend of increase with VD in all three studied vessels. In six infants, absent or reversed diastolic flow was observed at the height of VD. Four of these infants required V-P shunt. Immediate fall in PI occurred in all three vessels. Serial measurement of PI during VD reflects global changes in cerebrovascular resistance. Results confirmed PI could be a useful index in monitoring cerebral hemodynamic changes.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Lui
authors.forename: J
authors.initials: J
authors.lastname: Hellmann
authors.forename: A
authors.initials: A
authors.lastname: Sprigg
authors.forename: A
authors.initials: A
authors.lastname: Daneman
mesh_terms: D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D014463:Ultrasonography