Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways.
Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.
Teyton
L
L
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
O'Sullivan
D
D
Dickson
P W
PW
Lotteau
V
V
Sette
A
A
Fink
P
P
Peterson
P A
PA
D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte; D001483:Base Sequence; D001667:Binding, Competitive; D004247:DNA / Q000235:genetics; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000276:immunology / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism; D006367:HeLa Cells; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007163:Immunosorbent Techniques; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000276:immunology; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D021382:Protein Sorting Signals / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014162:Transfection
D000944:Antigens, Differentiation, B-Lymphocyte; D006683:HLA-DQ Antigens; C109756:HLA-DQ8 antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D008565:Membrane Proteins; D010455:Peptides; D021382:Protein Sorting Signals; C045084:invariant chain; D004247:DNA