title: [The efficacy of the intensive, short-duration chemotherapy of patients with cavitary pulmonary tuberculosis].
abstract: This study was carried out on 100 cases of cavitary pulmonary tuberculosis in patients eliminating tuberculosis bacilli, as noted at microscopic study. The treatment included four drugs (RHSZ) in 95 case, and 3 drugs in the remaining patients. All the treatments were tailored to individual needs. The duration of chemotherapy was of 6 months in 62 cases. It was prolonged to 9 months in 33 cases and to 12 months in 5 cases. In 81 patients the drugs were applied regularly. The results have demonstrated that at 6 months negative cultures were obtained in 98 patients although the excavations were closed in only 55 cases. At 9 months all the patients were negative but excavations were closed in only 71. Suppression of elimination of bacilli was achieved in 99 of the cases at 12 months, but the excavations were closed in only 92 of the patients. Ninety-nine patients were investigated after 2.5-3.0 years. Five of them were again positive, 94.5% were negative and the excavations were closed in 91.9%. The importance of the cavitary score is discussed with regard to the risk of renewed positivity, and an association is recommended of surgical collapsing and exeresis at the right time.
authors.affiliation: Spitalul de Pneumoftiziologie, Iaşi.
authors.forename: C
authors.initials: C
authors.lastname: Ionescu
authors.forename: A
authors.initials: A
authors.lastname: Arbore
authors.forename: A
authors.initials: A
authors.lastname: Nicola
authors.forename: A S
authors.initials: AS
authors.lastname: Arbore
authors.forename: T
authors.initials: T
authors.lastname: Mihăescu
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
vernacular_title: Eficienţa chimioterapiei intensive, de scurtă durată, la bolnavii cu tuberculoză pulmonară cavitară.