[Comparative analysis of the variants of experimental intra-aural pharmacophysical intervention].
The permeability of the blood-brain barrier of rabbits was measured in response to different methods of endaural pharmacophysical intervention and intravenous injection of radioactive DL (2,3-3H2) leucine. The concentration of labelled leucine was measured in the inner ear fluids. The experiments were performed using 28 rabbits. The maximum amount of the drug entered the labyrinth as a result of endaural superphonoelectrophoresis. In this case the positive effect was reached after a smaller number of therapeutic sessions. This method is recommended for clinical treatment of cochleovestibular lesions.
Pal'chun
V T
VT
Brodskiĭ
V Ia
VIa
Kriukov
A I
AI
Ramazashvili
Z I
ZI
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D004431:Ear, External; D007275:Injections, Intravenous; D007761:Labyrinthine Fluids / Q000502:physiology*; D007930:Leucine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010539:Permeability; D015612:Phonophoresis; D011817:Rabbits; D014316:Tritium
D014316:Tritium; D007930:Leucine
Sravnitel'nyĭ analiz variantov endaural'nogo farmakofizicheskogo vozdeĭstviia v éksperimente.