Induction of neutrophil accumulation by Chinese herbal medicines "hochu-etsuki-to" and "jyuzen-daiho-to".
"Hochu-etsuki-to" (HT) and "Jyuzen-daiho-to" (JT) are Chinese herbal medicines that have been used for the treatment of weakened physical strength and asthenic persons. Intraperitoneal injection of boiled water extracts in mice of HT and JT were found to induce a high accumulation of neutrophils 6 h after injection in a manner similar to that seen with the biological response modifier lentinan. The neutrophil accumulation by intraperitoneal injection of HT and JT increased dose-dependently.
Toda
S
S
Department of Pharmaceutical Science, Kansai Shinkyu College, Osaka, Japan.
Kimura
M
M
Ohnishi
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000187:drug effects*
D004365:Drugs, Chinese Herbal