(D, L) polylactide microspheres as embolic agent. A preliminary study.
Owing to their shape, accurately calibrated microspheres appear to be very suitable material for distal embolization. Moreover, the biocompatible (D, L) polyactide (PLA) microspheres possess two other valuable advantages: easy adjustment of their biodegradation rate, and incorporation of chemotherapeutic agents during their production. The authors describe the preparation of these (D, L) PLA microspheres and their clinical applications as a preliminary step to arterial chemoembolization.
Flandroy
P
P
Department of Neuroradiology, University of Liège, Sart Tilman, Belgium.
Grandfils
C
C
Collignon
J
J
Thibaut
A
A
Nihant
N
N
Barbette
S
S
Jerome
R
R
Teyssie
P
P
D000368:Aged; D001672:Biocompatible Materials; D002292:Carcinoma, Renal Cell / Q000556:secondary / Q000628:therapy; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000628:therapy; D008579:Meningioma / Q000628:therapy; D008863:Microspheres; D008875:Middle Aged; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000627:therapeutic use*; D013125:Spinal Neoplasms / Q000556:secondary / Q000628:therapy; D013242:Sterilization
D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)