Vascular response to cyclosporine and verapamil in the rat pancreas.
Marked elevation of vascular resistance in the rat pancreas is shown after systemic infusion of cyclosporine. Verapamil administration after cyclosporine reversed this effect and allowed maintenance of baseline vascular resistance and blood flow to the pancreas despite additional infusions of cyclosporine. Cyclosporine toxicity in rat pancreas may be directly related to increased vascular resistance. Verapamil might offer protection from this effect.
Jennings
W C
WC
Department of Surgery, University of Iowa College of Medicine, Iowa City 52242.
Corry
R J
RJ
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D010179:Pancreas / Q000098:blood supply* / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D003524:Cyclosporins; D014700:Verapamil