title: Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection.
abstract: sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS.
authors.affiliation: Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Alvarez-Cermeño
authors.forename: C
authors.initials: C
authors.lastname: Casado
authors.forename: L M
authors.initials: LM
authors.lastname: Villar
authors.forename: A
authors.initials: A
authors.lastname: Ferreira
authors.forename: J M
authors.initials: JM
authors.lastname: Varela
authors.forename: M
authors.initials: M
authors.lastname: Dominguez
authors.forename: A
authors.initials: A
authors.lastname: Bootello
authors.forename: R
authors.initials: R
authors.lastname: Najera
authors.forename: P
authors.initials: P
authors.lastname: Gonzalez-Porque
mesh_terms: D015658:HIV Infections / Q000097:blood* / Q000134:cerebrospinal fluid / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D012995:Solubility
chemical_list: D015395:Histocompatibility Antigens Class I