title: Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.
abstract: Experimental infections with field isolates of Eimeria meleagrimitis, E. adenoeides, E. gallopavonis, and E. dispersa in turkey poults were used to test the efficacy of maduramicin ammonium at 2.5-10 ppm in laboratory experiments. Infection with single or mixed species of coccidia reduced the weight gain of unmedicated infected controls and caused 18.1-65% mortality in two experiments. Maduramicin ammonium given at 5-7 ppm prevented mortality, significantly reduced droppings scores and oocyst passage, and improved weight gain to near that of the unmedicated uninfected controls. Maduramicin ammonium was tested at 4-7 ppm in a floor-pen trial lasting 10 weeks. Mortality from coccidiosis averaged 11.9% in unmedicated controls, compared with 0.6% with 4 ppm of maduramicin or no mortality with 5-7 ppm. Average weight gain and feed conversion at 10 weeks were significantly improved over unmedicated infected controls when maduramicin ammonium was given at 5-7 ppm. These results suggest that maduramicin ammonium is highly efficacious against field isolates of Eimeria in turkeys, especially within the range of 5-7 ppm in the feed.
authors.affiliation: Department of Poultry Science, University of Georgia, Athens 30602.
authors.forename: L R
authors.initials: LR
authors.lastname: McDougald
authors.forename: A L
authors.initials: AL
authors.lastname: Fuller
authors.forename: G F
authors.initials: GF
authors.lastname: Mathis
authors.forename: G T
authors.initials: GT
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use; D005260:Female; D007783:Lactones / Q000627:therapeutic use; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy*; D011897:Random Allocation; D014422:Turkeys / Q000469:parasitology*
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D007783:Lactones; C018091:maduramicin