Effects of calcitonin gene-related peptide and vasoactive intestinal peptide on nicotine-induced sweating in man.
The effects of two neuropeptides, calcitonin gene-related peptide and vasoactive intestinal peptide on nicotine-induced sweating in human skin were investigated. Intradermal injection of nicotine induced local sweating and each peptide, administered together with nicotine, inhibited these responses in a concentration-dependent manner. The concentration of calcitonin gene-related peptide for threshold and half-maximum inhibition were about 10(-10) M and 10(-8) M, respectively, while those of vasoactive intestinal peptide were approximately 10(-9) M and 10(-7) M, respectively. The results suggest that calcitonin gene-related peptide and vasoactive intestinal peptide have inhibitory effects on the nicotinic action, and release of endogenous calcitonin gene-related peptide and/or vasoactive intestinal peptide may influence sweating in human skin under physiological conditions in vivo.
Tanaka
E
E
Department of Physiology, Tokai University School of Medicine, Isehara, Japan.
Uchiyama
S
S
Nakano
S
S
D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D013546:Sweating / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D009538:Nicotine; D015740:Calcitonin Gene-Related Peptide