[The analgesic activity of coordination compounds of methionine enkephalin with divalent metals].
Coordination compounds of methenkephalin with transition metals: copper, cobalt, nickel and zinc were shown to be superior to morphine by the analgesic activity and to morphine and methenkephalin by the duration of the analgesic effect. A more stable relationship between opiate receptors and copper-containing methenkephalin was shown in the experiments on the isolated neuronal membrane.
Gromov
L A
LA
Serdiuk
E A
EA
D000085:Acetates; D019342:Acetic Acid; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D003035:Cobalt / Q000627:therapeutic use; D003300:Copper / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004744:Enkephalin, Methionine / Q000627:therapeutic use*; D008670:Metals / Q000627:therapeutic use*; D051379:Mice; D009020:Morphine / Q000627:therapeutic use; D009532:Nickel / Q000627:therapeutic use; D011396:Promedol / Q000627:therapeutic use; D013035:Spasm / Q000139:chemically induced / Q000188:drug therapy; D015032:Zinc / Q000627:therapeutic use
D000085:Acetates; D000700:Analgesics; D008670:Metals; D003035:Cobalt; D004744:Enkephalin, Methionine; D011396:Promedol; D009020:Morphine; D003300:Copper; D009532:Nickel; D015032:Zinc; D019342:Acetic Acid
Anal'geticheskaia aktivnost' koordinatsionnykh soedineniĭ metionin-énkefalina s dvukhvalentnymi metallami.