[Comparative study of the hypotensive action of monotherapy using hydrochlorothiazide and its combination with triamterene and amiloride and their effect on hemodynamics at rest and during exercise therapy].
A comparative study was undertaken to examine antihypertensive effects and impact of hydrochlorothiazide (HCT) alone or in combination with triamterene or amiloride on the hemodynamics of 79 patients with Stage II hypertension. With small doses, the resting recumbent systolic blood pressure was decreased to a significantly greater extent when the combinations (HCT + triamterene, in particular HCT + amiloride) were used than when the agent alone was given; diastolic blood pressure became lower only with a combination of HCT + amiloride than its monotherapy. When double doses were used, no potentiating antihypertensive action of potassium-sparing diuretics was ascertained. It was concluded that it was more preferable to use HCT in combination with diuretics, amiloride in particular, than as monotherapy.
Glezer
G A
GA
Lipko
D S
DS
Levinzon
A M
AM
D000584:Amiloride / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D015444:Exercise / Q000502:physiology; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D012146:Rest / Q000502:physiology; D014223:Triamterene / Q000008:administration & dosage*
D006852:Hydrochlorothiazide; D000584:Amiloride; D014223:Triamterene
Sravnitel'noe izuchenie gipotenzivnogo éffekta i vliianiia na gemodinamiku v pokoe i pri nagruzochnykh testakh monoterapii gidro- khlorotiazidom i sochetani ego s triamterenom i amiloridom.