Pulsatile two-dimensional flow and plaque formation in a carotid artery bifurcation.
Velocity and pressure fields, streamlines and wall shear stress distributions were numerically obtained for two-dimensional, steady and pulsatile flow in a carotid artery segment. Distinct regions of reverse flow near the bifurcation and wavy flow patterns in the branching channels were observed during portions of the pulse. These phenomena disappear at the end of the systolic phase of the cardiac cycle. A previously validated plaque formation model predicts that plaque sites and the local extent of atherosclerotic lesions are similar for those present on human angiograms.
Nazemi
M
M
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695-7910.
Kleinstreuer
C
C
Archie
J P
JP
D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D002340:Carotid Artery Diseases / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D013314:Stress, Mechanical