[The induction of tolerance in mice for a human melanoma graft].
Mouse skin allografts and intramuscular BRO human melanoma xenografts were successfully established in phenotypically normal mice after inducing immunological tolerance in the recipients. Tolerance was achieved by inoculating allogenic embryonic liver cells after the whole-body irradiation. No immunological rejection was evident in BRO xenografts for 34 days after transplantation. During this period the BRO cells invaded neighboring tissues and formed distant micrometastases in the lungs.
Bogush
T A
TA
Lokshin
A
A
Smirnova
G B
GB
Iushkov
S F
SF
Karpov
I A
IA
Ovumian
G Sh
GSh
Kastrykina
V N
VN
Chimishkian
K L
KL
D000818:Animals; D004622:Embryo, Mammalian; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology* / Q000528:radiation effects; D016031:Liver Transplantation / Q000276:immunology; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D012878:Skin Neoplasms / Q000276:immunology*; D016038:Skin Transplantation / Q000276:immunology; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
Induktsiia tolerantnosti u mysheĭ k transplantatu melanomy cheloveka.