title: Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs.
abstract: The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4% at 1 microgram/kg) and the superior mesenteric artery (49.0 +/- 16.8% at 1 microgram/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4 +/- 1.2% at 1 microgram/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: R
authors.initials: R
authors.lastname: Hosotani
authors.forename: M
authors.initials: M
authors.lastname: Kogire
authors.forename: R
authors.initials: R
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Yun
authors.forename: S
authors.initials: S
authors.lastname: Higashide
authors.forename: H
authors.initials: H
authors.lastname: Minote
authors.forename: K
authors.initials: K
authors.lastname: Takaori
authors.forename: H
authors.initials: H
authors.lastname: Kaji
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008638:Mesenteric Arteries; D011169:Portal Vein; D011994:Recombinant Proteins / Q000494:pharmacology; D013152:Splanchnic Circulation / Q000187:drug effects*
chemical_list: D011994:Recombinant Proteins; D004815:Epidermal Growth Factor