title: Antioxidant activity of and interleukin production affected by honey bee venom.
abstract: Honey bee venom is found to inhibit significantly nonenzymatic lipid peroxidation. It also possesses a considerable hydroxyl radical scavenging activity, evaluated by its competition with dimethyl sulfoxide for HO.. These results, in relation to the in vitro suppression mainly of interleukin-1 production offered by honey bee venom, may further support that antioxidant activity is involved in the anti-inflammatory activity of honey bee venom.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Rekka
authors.forename: L
authors.initials: L
authors.lastname: Kourounakis
authors.forename: P
authors.initials: P
authors.lastname: Kourounakis
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000378:metabolism / Q000494:pharmacology; D005557:Formaldehyde / Q000378:metabolism; D016166:Free Radical Scavengers; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology
chemical_list: D000975:Antioxidants; D001514:Bee Venoms; D016166:Free Radical Scavengers; D007375:Interleukin-1; D007376:Interleukin-2; D005557:Formaldehyde; D004121:Dimethyl Sulfoxide