title: Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum.
abstract: 22-Hydroxytingenone was reisolated from a new source, Glyptopetalum sclerocarpum M. Laws and, for the first time, its unambiguous 13C-NMR assignments were accomplished through the use of APT, HETCOR, and selective INEPT spectroscopy. Intense, but nonspecific cytotoxic activity was observed when this substance was evaluated with a battery of cell lines comprised of the P-388 lymphocytic leukemia, KB carcinoma of the nasopharynx, and a number of human cancer cell types, i.e. HT-1080 fibrosarcoma, LU-1 lung cancer, COL-2 colon cancer, MEL-2 melanoma, and BC-1 breast cancer.
authors.affiliation: Department of Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand.
authors.forename: R
authors.initials: R
authors.lastname: Bavovada
authors.forename: G
authors.initials: G
authors.lastname: Blaskó
authors.forename: H L
authors.initials: HL
authors.lastname: Shieh
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; D014315:Triterpenes; C066185:tingenin B