Macromolecular adducts and related biomarkers in biomonitoring and epidemiology of complex exposures.
In order to evaluate the potential of biological markers in epidemiology and risk assessment of complex exposures, we review recent studies of macromolecular adducts and oncogene activation in human populations. Results are discussed in terms of the strengths and weaknesses of various study designs in order to identify the most promising approaches for future research.
Perera
F
F
Columbia University School of Public Health, New York, NY 10032.
Jeffrey
A
A
Santella
R M
RM
Brenner
D
D
Mayer
J
J
Latriano
L
L
Smith
S
S
Young
T L
TL
Tsai
W Y
WY
Hemminki
K
K
D014408:Biomarkers, Tumor / Q000032:analysis*; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D016022:Case-Control Studies; D004784:Environmental Monitoring; D006801:Humans; D008137:Longitudinal Studies; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control; D009857:Oncogenes / Q000187:drug effects*; D012307:Risk Factors
D014408:Biomarkers, Tumor; D002274:Carcinogens, Environmental