[Free amino acids of the liver and the characteristics of the amino acid metabolism in the liver and brain after cyanamide administration to rats].
A single administration to rats of cyanamide (60 mg/kg, for 1 hour) was found to decrease the contents of cysteate, serine, glutamate, glycine, alanine, valine, methionine, isoleucine, tyrosine, ethanolamine, ornithine and histidine that may be considered as a manifestation on the drug hepatotoxicity. The activities of transaminases, glutamate dehydrogenase, pyruvate dehydrogenase remained unchanged. Cyanamide effects were considerably abolished by the supplementary ethanol administration (0.5 g/kg). Cyanamide failed to affect vitamin-dependent enzymes reflecting thiamine pyrophosphate, pyridoxal phosphate and flavine adenine dinucleotide status of the rat organism.
Ostrovskiĭ
S Iu
SIu
Gorenshteĭn
B I
BI
Dosta
G A
GA
Karaedova
L M
LM
Nefedov
L I
LI
D000596:Amino Acids / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003484:Cyanamide / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats
D000596:Amino Acids; D000431:Ethanol; D003484:Cyanamide
Svobodnye aminokisloty pecheni i osobennosti obmena aminokislot pecheni i mozga pri vvedenii tsiamida krysam.