Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.
Karanewsky
D S
DS
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
Badia
M C
MC
Ciosek
C P
CP
Robl
J A
JA
Sofia
M J
MJ
Simpkins
L M
LM
DeLange
B
B
Harrity
T W
TW
Biller
S A
SA
Gordon
E M
EM
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000096:biosynthesis*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000924:Anticholesteremic Agents; D002087:Butyrates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D009943:Organophosphorus Compounds; C066279:SQ 33600; D002784:Cholesterol