title: Abnormal expression of dipeptidylpeptidase IV activity in enterocyte brush-border membranes of children suffering from coeliac disease.
abstract: Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compared with previous results showing coeliac disease to inhibit disaccharidase activities selectively.
authors.affiliation: Department of Cell Biology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge.
authors.forename: M W
authors.initials: MW
authors.lastname: Smith
authors.forename: A D
authors.initials: AD
authors.lastname: Phillips
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D002446:Celiac Disease / Q000201:enzymology*; D002462:Cell Membrane / Q000378:metabolism; D002648:Child; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000201:enzymology*; D008297:Male; D008871:Microvilli / Q000201:enzymology*
chemical_list: D000469:Alkaline Phosphatase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases