title: [The relationship between alveolar apertures and alveolar size and smoking history in humans, and experimental studies on air pollutants].
abstract: Using surgical specimens from patients with lung tumor, alveolar apertures and alveolar sizes were quantitatively assessed using scanning electron microscopy. Compared with smoking habits, increased apertures, defined as alveolar destruction were observed in patients smoking more than 35 years, whereas alveolar size was increased in patients, with a 15-year smoking history. Experimental studies with exposure to NO2, O3 and H2SO4 mist showed that exposure of NO2 and H2SO4 could induce epithelial injury such as disappearance of cilia in the central airways.
authors.affiliation: Department of Medicine 1, Tokyo Women's Medical College.
authors.forename: A
authors.initials: A
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Inano
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Takizawa
authors.forename: K
authors.initials: K
authors.lastname: Matsuba
authors.forename: S
authors.initials: S
authors.lastname: Morinobu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamano
authors.forename: N
authors.initials: N
authors.lastname: Nagao
authors.forename: Y
authors.initials: Y
authors.lastname: Ishihara
authors.forename: J
authors.initials: J
authors.lastname: Kagawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000633:toxicity; D010126:Ozone / Q000633:toxicity; D011650:Pulmonary Alveoli / Q000648:ultrastructure*; D012907:Smoking / Q000473:pathology*; D013464:Sulfuric Acids / Q000633:toxicity; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D013464:Sulfuric Acids; D010126:Ozone; C033158:sulfuric acid; D009585:Nitrogen Dioxide