Excremental studies in human neonates. Identification of zinc coproporphyrin as a marker for meconium.
Zinc coproporphyrin, isomers I and III (I:III ratio, approximately 8:1), was identified in human meconium using high-performance liquid chromatography, ultraviolet-visible absorbance spectroscopy, and emission fluorescence spectroscopy. The high levels of zinc coproporphyrin in the first stools of life decrease steadily as meconium is evacuated and reach a plateau at comparatively negligible levels after complete evacuation of meconium. Zinc coproporphyrin can be used as a marker for human meconium.
Gourley
G R
GR
Department of Pediatrics, University of Wisconsin School of Medicine, Madison.
Kreamer
B
B
Arend
R
R
D000375:Aging / Q000378:metabolism; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D003306:Coproporphyrins / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D005333:Fetus / Q000378:metabolism*; D005453:Fluorescence; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000378:metabolism*; D014466:Ultraviolet Rays; D015032:Zinc / Q000378:metabolism*
D003306:Coproporphyrins; D015032:Zinc