title: [Developments in the treatment of osteosarcoma since 1979. Report of the statistics at the Centre Léon-Bérard].
abstract: Seventy-two patients with a localized osteosarcoma were treated between September 1979 and December 1987 by neoadjuvant chemotherapy, local surgery and post-operative chemotherapy. Chemotherapy regimens varied throughout the years but always comprised high dose methotrexate with leucovorin rescue and adriamycin pre-operatively for children under the age of 15, and ifosfamid and cis platinum in adults. Post-operative chemotherapy for bad responders (greater than 10% of residual malignant cells), was at first an association of adriamycin and cis platinum, and later of holoxan and cis platinum. Surgery changed from amputation to local conservative surgery (graft or prosthesis) which is now the most frequent surgery--61% of the patients are alive and disease-free at 5 years. Good responders to pre-operative chemotherapy have a much better prognosis (81% at 5 years) than bad responders (45%). There is no significant difference according to age or pre-operative chemotherapy regimen.
authors.affiliation: Centre Léon-Bérard, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Brunat-Mentigny
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.forename: R
authors.initials: R
authors.lastname: Kohler
authors.forename: R
authors.initials: R
authors.lastname: Blondet
authors.forename: J
authors.initials: J
authors.lastname: Bérard
authors.forename: P
authors.initials: P
authors.lastname: Chauvot
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: J P
authors.initials: JP
authors.lastname: Carret
authors.forename: P
authors.initials: P
authors.lastname: Jonas
authors.forename: L M
authors.initials: LM
authors.lastname: Patricot
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D008297:Male; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D007069:Ifosfamide
vernacular_title: [Evolution du traitement de l'ostéosarcome depuis 1979. A propos de la statistique du Centre Léon-Bérard.