Membranous nephropathy associated with giant lymph node hyperplasia. A case report with histological and ultrastructural studies.
A young woman presented with nephrotic syndrome due to membranous nephropathy and a localized form of giant lymph node hyperplasia (Castleman's disease) occurring as a large intra-abdominal mass. Five months after surgical removal of the mass, only mild proteinuria persisted. Twenty months later a second kidney biopsy showed a near-normal morphology. Six years later the patient was free of symptoms and had normal urinalysis. Reviewing the pertinent literature, it seems to be the first case of a biopsy-proven cure of membranous nephropathy in a patient with membranous nephropathy and Castleman's disease.
Ruggieri
G
G
Servizio di Nefrologia e Dialisi, Ospedale San Giacomo, Roma, Italia.
Barsotti
P
P
Coppola
G
G
Spinelli
C
C
Balducci
A
A
Ventola
F R
FR
d'Adamo
G
G
Tata
M V
MV
Marinozzi
V
V
D000293:Adolescent; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008854:Microscopy, Electron