Enhanced antibody production in W/Wv mice exposed to ozone.
To investigate the modulation of defense mechanisms by ozone (O3) exposure, mast-cell-deficient WBB6F1-W/WV and normal WBB6F1(-)+/+ mice were continuously exposed to 0.8 ppm O3 for 7 days. Although no differences in weights of lung, thymus and spleen were shown between exposed and control W/WV mice, antibody response to sheep red blood cells (SRBC) in exposed W/WV mice was markedly enhanced compared to control W/WV mice. In normal +/+ mice O3 exposure induced an increase in lung weight but did not enhance antibody production. These studies suggest that the susceptibility of W/WV mice to O3 may be different from that of +/+ mice.
Fujimaki
H
H
Basic Medical Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan.
Kawagoe
A
A
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D008168:Lung / Q000033:anatomy & histology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010126:Ozone / Q000633:toxicity*; D012756:Sheep; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology
D010126:Ozone