title: Effect of electrical stimulation on middle latency response in the guinea pig.
abstract: A temporary threshold shift (TTS) has been demonstrated in the electrically evoked middle latency response (EMLR) following exposure to moderate levels of continuous electrical stimulation via a cochlear implant. The threshold at which the EMLR was elicited in chronically implanted guinea pigs was elevated by approximately 100% following 30 minutes of moderate intensity (200 microA or more) sinusoidal electrical stimulation of the cochlea. Results obtained under anesthesia varied unacceptably. In awake animals, EMLR thresholds were stable over time and consistent TTSs were observed. The threshold returned to prestimulation levels within 4 hours following termination of the stimulation. The possibility of histopathologic changes and the relevance of these findings in setting safe output levels for cochlear implant processors are discussed.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.
authors.forename: S C
authors.initials: SC
authors.lastname: Cannon
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Crowther
authors.forename: D
authors.initials: D
authors.lastname: Moscow
mesh_terms: D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology*; D003051:Cochlea / Q000502:physiology*; D003054:Cochlear Implants; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006168:Guinea Pigs