title: Imipenem/cilastatin treatment of acute infections in AIDS/ARC patients.
abstract: We studied the clinical efficacy and safety of imipenem, a broad spectrum beta-lactam antibiotic, in acute bacterial infections in 21 patients with AIDS or AIDS-related complex (ARC). Imipenem/cilastatin was administered as a 30-min intravenous infusion using a dose of 500 mg/8 h. Bacterial pathogens were isolated before treatment in 80% of cases; 87.5% of all strains were susceptible to imipenem in vitro. Treatment resulted in rapid control of the infections in 80% of patients. Clinical and laboratory adverse reactions probably related to imipenem treatment were noted in 8 patients.
authors.affiliation: Department of Infectious Diseases, University of Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giacometti
authors.forename: P
authors.initials: P
authors.lastname: Pongetti
authors.forename: E
authors.initials: E
authors.lastname: Petrelli
authors.forename: G
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000208:Acute Disease; D000328:Adult; D015377:Cilastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy*; D012307:Risk Factors; D018805:Sepsis / Q000150:complications / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination