title: [8-MOP serum level profile following administration of Geroxalen to patients with psoriasis and a control group].
abstract: After 8-MOP application (Geroxalen) the mean serum levels with 11 single values over 8 hours from 21 psoriatics with squamous infiltrative plaques do not differ from serum level curves of 46 healthy volunteers (Psoriatics: maximum plasma level cmax 189 nm 8 MOP/ml serum at the time tmax 1,2h; area under the curve AUC0-8 284 ng.ml-1.h.
  
  
  METHODS
  cmax 193 ng 8 MOP/ml serum; tmax 0.9h; AUC0-8 290 ng.ml-1.h). A malabsorption of 8-MOP in psoriatic patients could not be found in our study, although this is described for fat among other.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Karl-Marx-Universität Leipzig.
authors.forename: T
authors.initials: T
authors.lastname: Walther
authors.forename: U F
authors.initials: UF
authors.lastname: Haustein
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy
chemical_list: D008730:Methoxsalen
vernacular_title: 8-MOP-Serumspiegelprofile nach Einnahme von Geroxalen bei Psoriatikern und einer Kontrollgruppe.