title: Pediatric brainstem glioma. Post-radiation clinical and MR follow-up.
abstract: Thirty-four pediatric patients, twenty with presumed and fourteen with biopsy or autopsy proven brainstem gliomas were imaged by CT and MR before radiation therapy. Twenty-eight patients received radiotherapy. Of these, eighteen fit the protocol for combined clinical and MR post-treatment evaluation. No cases of radionecrosis were seen at autopsy. This study shows that MR can demonstrate tumor response to radiation therapy, tumor progression prior to clinical deterioration, post-treatment cyst formation and hemorrhage. Although MR clinical correlation was not optimal on six week post-treatment evaluation, 4-10 month post-treatment MR scanning correlated well with clinical evaluation. MR appears useful in post-therapeutic monitoring of tumor response.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia.
authors.forename: R R
authors.initials: RR
authors.lastname: Smith
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
authors.forename: R J
authors.initials: RJ
authors.lastname: Packer
authors.forename: D B
authors.initials: DB
authors.lastname: Hackney
authors.forename: L T
authors.initials: LT
authors.lastname: Bilaniuk
authors.forename: L N
authors.initials: LN
authors.lastname: Sutton
authors.forename: H I
authors.initials: HI
authors.lastname: Goldberg
authors.forename: R I
authors.initials: RI
authors.lastname: Grossman
authors.forename: L
authors.initials: L
authors.lastname: Schut
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D001933:Brain Stem; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects; D003560:Cysts / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests