[Personal experience with antibiotic prophylaxis in extensive otorhinolaryngologic procedures].
The authors compare the effectiveness of three types of antibiotic prophylaxis (1. cephazoline, 2. combination ampicillin + oxacillin, 3. clindamycin) in a group of 32 patients with resection of oropharyngeal carcinomas and in a group of 47 laryngectomies with cervical block resection. The criterium is the incidence of postoperative infections, which called for a change of antibiotic treatment. The authors evaluates favourably prophylaxis with cephazoline and clindamycin; the incidence of complications is within the range of 17-30%. In ampicillin + oxacillin therapy unsatisfactory results with a 46% incidence of inflammatory complications were recorded. A gram-negative flora causes 45% infectious complications; the author also draws attention to the danger of anaerobic infections. In a primarily contaminated oropharyngeal area there is an incidence of postoperative infections by 30% higher in all types of evaluated prophylaxis, as compared with the laryngocervical area.
Taudy
M
M
Otorinolaryngologická katedra FVL KU, Praha.
Betka
J
J
D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy; D002437:Cefazolin / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D006801:Humans; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*; D010068:Oxacillin / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy; D011292:Premedication
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D000667:Ampicillin; D002437:Cefazolin; D010068:Oxacillin
Nase zkusenosti s antibiotickou profylaxí pri rozsáhlých otolaryngologických výkonech.