Expression of cellular effector functions and production of reactive nitrogen intermediates: a comparative study including T lymphocytes, T-like cells, neutrophil granulocytes, and mononuclear phagocytes.
The ability of various cell types to secrete reactive nitrogen intermediates (RNI) upon functional activation was comparatively assessed. Neither in T lymphocyte clones mediating MHC class I or class II antigen-restricted killing via alpha/beta T cell receptor (TcR) or MHC-unrestricted killing via gamma/delta TcR, nor in peripheral blood mononuclear cells expressing natural killer or lymphokine-activated killer activity, target cell lysis was associated with detectable RNI production. Also, activated neutrophil granulocytes did not secrete RNI. In contrast, bone marrow-derived mononuclear phagocytes, activated to express tumoricidal activity, secreted marked RNI activity.
Keller
R
R
Institute for Immunology and Virology, University of Zurich, Switzerland.
Keist
R
R
Erb
P
P
Aebischer
T
T
De Libero
G
G
Balzer
M
M
Groscurth
P
P
Keller
H U
HU
D000818:Animals; D001120:Arginine / Q000378:metabolism; D002999:Clone Cells; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D051381:Rats; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*
D009573:Nitrites; D009569:Nitric Oxide; D001120:Arginine; D009584:Nitrogen