Predictive values of CA 125 antigen levels and CT scan in second-look procedures for ovarian cancer.
23 patients with ovarian cancer were investigated 10 days after their last regimen of chemotherapy by CT scan and CA 125 in comparison with 'second-look' findings. In 17 out of 23 cases the CT scan results correlated with the operative ones. There were 6 false-negative findings but no false-positives. In all cases serum CA 125 levels correlated with the second-look operation. Our data suggest that the upper limit of CA 125, especially for patients, with negative findings, is less than or equal to 20 U/ml which is much lower than that of 35 U/ml, which is generally accepted. They also indicate the value of CA 125 in the detection of persistent ovarian cancer and the value of the CT scan in the detection of liver metastases. According to the above findings we question the value of the second-look operation in certain cases of ovarian cancer.
Aravantinos
D
D
First Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Greece.
Michalas
S
S
Papazefkos
V
V
Christoforaki
M
M
Stypsaneli
A
A
Vlachos
G
G
Athanasiadis
P
P
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012086:Reoperation; D014057:Tomography, X-Ray Computed
D015295:Antigens, Tumor-Associated, Carbohydrate