title: Disintegrins: a family of integrin inhibitory proteins from viper venoms.
abstract: Disintegrins represent a new class of low molecular weight, RGD-containing, cysteine-rich peptides isolated from the venom of various snakes. They interact with the beta 1 and beta 3 families of integrins and their potency is at least 500-2000 times higher than short RGDX peptides. Analysis of the amino acid sequences of 14 different disintegrins suggests that the RGD sequence, in the spatial configuration determined by the appropriate pairing of the cysteine residues, functions as a cell recognition site. However, certain nonconserved amino acids appear to modify the activity of disintegrins, their specificity for various receptors, and their ability to compete specifically with various ligands.
authors.affiliation: Department of Biological Chemistry, Merck, Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gould
authors.forename: M A
authors.initials: MA
authors.lastname: Polokoff
authors.forename: P A
authors.initials: PA
authors.lastname: Friedman
authors.forename: T F
authors.initials: TF
authors.lastname: Huang
authors.forename: J C
authors.initials: JC
authors.lastname: Holt
authors.forename: J J
authors.initials: JJ
authors.lastname: Cook
authors.forename: S
authors.initials: S
authors.lastname: Niewiarowski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis*; D014757:Viper Venoms / Q000032:analysis*
chemical_list: D016023:Integrins; D009842:Oligopeptides; D014757:Viper Venoms; C047981:arginyl-glycyl-aspartic acid