title: [Platelet aggregation in patients with coronary disease treated with nifedipine].
abstract: The effect of nifedipine on the aggregation of blood platelets has been studied in patients with coronary heart disease. The study involved 78 males, aged between 36 and 64 years (mean age 51 years). The level of aggregation was evaluated before and after a single nifedipine dose of 10 mg (in 15 patients) and of 20 mg (in 34 patients) as well as before and after the treatment with nifedipine (of 29 patient) with a daily dose of 30 mg for two weeks. Aggregation of blood platelets induced by adenosine--diphosphate in of concentrations 1 microM/ml and of 5 microM/ml were estimated by the Born method. It was found that nifedipine reduces the aggregation of the blood platelets in patients with coronary heart disease following single and long-term treatment.
authors.affiliation: III Kliniki Chorób Wewnetrznych IMW w Lodzi.
authors.forename: W
authors.initials: W
authors.lastname: Tkaczewski
authors.forename: J H
authors.initials: JH
authors.lastname: Goch
authors.forename: G
authors.initials: G
authors.lastname: Kruszyński
authors.forename: A
authors.initials: A
authors.lastname: Ryniec
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D009543:Nifedipine
vernacular_title: Agregacja krwinek płytkowych u osób z choroba wieńcowa leczonych nifedypina.