Cell injury associated calcium oxalate crystalluria.
Renal tubular cell damage, resulting in membranuria, was induced by the administration of subcutaneous gentamicin to male Sprague-Dawley rats. One group of rats received gentamicin only, while a second group was given gentamicin plus ethylene glycol in drinking water at a concentration which increased urine oxalate but alone did not cause calcium oxalate crystalluria. Crystalluria occurred early in the combined treatment groups and persisted for the duration of the experiment. Crystalluria was not present in animals receiving gentamicin or ethylene glycol only. These results suggest that cellular fragments can serve as heterogeneous foci for the nucleation of calcium oxalate crystals.
Hackett
R L
RL
Department of Pathology, University of Florida, Gainesville 32610.
Shevock
P N
PN
Khan
S R
SR
D000818:Animals; D002129:Calcium Oxalate / Q000652:urine*; D002462:Cell Membrane / Q000187:drug effects; D003460:Crystallization; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000009:adverse effects; D005839:Gentamicins / Q000009:adverse effects*; D007669:Kidney Calculi / Q000139:chemically induced* / Q000652:urine; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000652:urine; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005026:Ethylene Glycols; D005839:Gentamicins; D002129:Calcium Oxalate; D019855:Ethylene Glycol