title: Nitrendipine-induced gingival hyperplasia. First case report.
abstract: Drug-induced gingival hyperplasia is well documented within the literature. It has been associated with phenytoin, cyclosporine, and calcium channel blocking agents. Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia. The clinical and histologic presentation of this side effect and possible biochemical mechanisms of pathogenesis are discussed.
authors.affiliation: Department of Oral Diagnostic Sciences, UTHSCH, Dental Branch, Houston.
authors.forename: R S
authors.initials: RS
authors.lastname: Brown
authors.forename: P
authors.initials: P
authors.lastname: Sein
authors.forename: R
authors.initials: R
authors.lastname: Corio
authors.forename: W K
authors.initials: WK
authors.lastname: Bottomley
mesh_terms: D000368:Aged; D004789:Enzyme Activation / Q000187:drug effects; D005494:Folic Acid Deficiency / Q000139:chemically induced; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009568:Nitrendipine / Q000009:adverse effects* / Q000494:pharmacology; D011506:Proteins / Q000037:antagonists & inhibitors
chemical_list: D011506:Proteins; D009568:Nitrendipine