Effects of endothelin on renal hemodynamics and renal function in anesthetized dogs.
Porcine endothelin was infused directly into the renal artery of anesthetized dogs to evaluate the renal action of endothelin. Endothelin (0.2 to 5.0 ng/kg/min) elicited a dose-dependent reduction in the renal blood blow with no changes in systemic blood pressure. Endothelin infusion (0.2 ng/kg/min) decreased the renal blood flow by 30% and urinary sodium excretion by 50% without any changes in the glomerular filtration rate. However, higher doses did reduce glomerular filtration rate. These data suggest that endothelin preferentially constricts efferent arterioles and that endothelin may enhance the renal reabsorption of sodium.
Miura
K
K
Department of Pharmacology, Osaka City University Medical School, Japan.
Yukimura
T
T
Yamashita
Y
Y
Shichino
K
K
Shimmen
T
T
Saito
M
M
Okumura
M
M
Imanishi
M
M
Yamanaka
S
S
Yamamoto
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000502:physiology*; D012964:Sodium / Q000652:urine
D016232:Endothelins; D012964:Sodium