Modulation of gut wall paf-acether and precursors by intestinal microflora.
Comparison between holoxenic and axenic mice led to the conclusion that the presence of an intestinal microflora produced a decrease in wall paf in conventional mouse caecum, whereas an increase in wall lyso-paf and alkyl-acyl-glycerophosphocholine (A-A-GPC) content was noticed. By contrast, the presence of flora had no significant incidence on wall paf, lyso-paf and A-A-GPC content of conventional mouse jejunum. Thus, the modulation of gut wall phospholipid composition by intestinal microflora is evidenced for the first time.
Denizot
Y
Y
INSERM U200, Clamart, France.
Raibaud
P
P
Ducluzeau
R
R
Ladiré
M
M
Thomas
Y
Y
Benveniste
J
J
D000818:Animals; D002432:Cecum / Q000378:metabolism* / Q000382:microbiology; D005856:Germ-Free Life; D007583:Jejunum / Q000378:metabolism* / Q000382:microbiology; D008244:Lysophosphatidylcholines / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000378:metabolism*
C014307:1-acylglycerylphosphorylcholine; D008244:Lysophosphatidylcholines; C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor