Cytotoxic and antitumor constituents in pericarps of Mallotus japonicus.
A variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved to be significantly cytotoxic in culture. One of them, 3-(3,3-dimethylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzyl )- phloracetophenone showed an excellent cytotoxicity against all target tumor cells and a marked prolongation of life-span in mice bearing L5178Y leukemia.
Arisawa
M
M
Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Fujita
A
A
Morita
N
N
Koshimura
S
S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D004359:Drug Therapy, Combination; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010844:Picibanil / Q000008:administration & dosage / Q000494:pharmacology; D010944:Plants / Q000032:analysis*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D007155:Immunologic Factors; D010844:Picibanil