title: A simple experimental technique for interstitial iridium-192 high dose-rate afterloading.
abstract: A simple experimental technique for interstitial iridium-192 high dose-rate afterloading is described which allows to perform experimental brachytherapy on a rat tumor model. To illustrate the possibilities and limitations of the technique, rhabdomyosarcoma R1H of the rat were subjected to a combined brachy- and teletherapy treatment applying a total dose of 60 Gy in fractions of 2 Gy. The results show that the surgical procedure had no influence on tumor response. However, would healing was considerably disturbed in animals which received afterloading treatment.
authors.affiliation: Institute of Biophysics and Radiobiology, University of Hamburg, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Milewsky
authors.forename: T
authors.initials: T
authors.lastname: Fassbender
authors.forename: F
authors.initials: F
authors.lastname: Würschmidt
authors.forename: H P
authors.initials: HP
authors.lastname: Beck-Bornholdt
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D012208:Rhabdomyosarcoma / Q000532:radiotherapy; D012513:Sarcoma, Experimental / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes