title: Complexes involving quercetin, DNA and Cu(II).
abstract: The genotoxic flavonoid, quercetin, was shown to bind to both double-stranded and single-stranded DNA with concomitant changes in absorption spectrum and fluorescence emission spectrum of quercetin. Quercetin and Cu(II) were shown to form a charge transfer complex that decayed in oxygen-dependent reaction(s) and this decay was accelerated by DNA. Analysis of the three component system, DNA--querectin--Cu(II), led to a discussion of the complexes likely to be involved in the initial reactions that lead, ultimately, to strand scission of DNA.
authors.affiliation: Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
authors.forename: A
authors.initials: A
authors.lastname: Rahman
authors.lastname: Shahabuddin
authors.forename: S M
authors.initials: SM
authors.lastname: Hadi
authors.forename: J H
authors.initials: JH
authors.lastname: Parish
mesh_terms: D003300:Copper / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism; D004347:Drug Interactions; D011794:Quercetin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D004277:DNA, Single-Stranded; D003300:Copper; D004247:DNA; D011794:Quercetin