[Electrophoretic studies of the composition of peripheral mononuclear cells during operations with extracorporeal circulation].
The increased incidence of infections after operations can be connected with changes of the immunocompetent cells. Mononuclear blood-cells were investigated by means of the cell electrophoresis during and after operations under the extracorporeal circulation, because electrophoretically different cells correlate with several immunological phenotypes. A heavy decrease of the electrophoretic quick mobility cell population was found out on the first postoperative day above all. This change allows itself the interpretation by decreasing the T-lymphocytes connected to a relative increase of monocytes, B-cells, and immature T-cells. Besides a lower quotient of the quick and low mobility T-cells refers to a lower immunoregulatory quotient CD4/CD8 after operation. Changes of the cell composition becomes evident also in dependence on the bypass length and the blood supply.
Rychly
J
J
Klinik für Innere Medizin, Bereichs Medizin, Universität Rostock, DDR.
Oldag
D
D
Krüger
A D
AD
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004586:Electrophoresis; D005112:Extracorporeal Circulation; D006801:Humans; D007108:Immune Tolerance; D007239:Infections / Q000209:etiology*; D007963:Leukocytes, Mononuclear / Q000737:chemistry*; D008875:Middle Aged
Elektrophoretische Untersuchungen zur Zusammensetzung peripherer mononukleärer Zellen bei Operationen im extrakorporalen Kreislauf.