Malleus head fixation: association with pseudohypoparathyroidism.
Pseudohypoparathyroidism (PHP) is a heterogenous syndrome resulting from bone and renal resistance to parathyroid hormone (PTH). Hypocalcemia and hyperphosphatemia occur despite elevated PTH levels. Head and neck manifestations of PHP include tetany, laryngeal spasm, and ectopic calcification in the eye, dentition, subcutaneous tissue and brain. The first case of malleus head fixation caused by ectopic calcification in a PHP patient is reported. Normalization of serum calcium and phosphate levels does not appear to retard or correct this abnormality. Ossiculoplasty or amplification is currently the recommended treatment in PHP patients with malleus head fixation.
LaRouere
M J
MJ
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Hospitals, Ann Arbor 48109.
Coleman
G
G
Telian
S A
SA
Kemink
J L
JL
D000328:Adult; D002114:Calcinosis / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006314:Hearing Loss, Conductive / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008307:Malleus / Q000503:physiopathology* / Q000601:surgery; D011379:Prognosis; D011547:Pseudohypoparathyroidism / Q000150:complications* / Q000503:physiopathology / Q000601:surgery