Some electrochemical characteristics of synthetic analogs of nucleic acid components. I. Derivatives of cytidine and arabinosylcytosine. An attempt to find correlation among some of their properties.
The polarographic reduction and parameter tg alpha of a series of natural and synthetic pyrimidine nucleosides, cytidine derivatives, and the cancerostatic agent arabinosylcytosine were studied. Correlations were found between these newly determined characteristics and capacity factor kappa from HPLC analysis, growth inhibition of E. coli B bacteria, deamination of nucleosides by cytidine deaminase, DNA synthesis, and rate of biotransformation and lipophilicity expressed as log P. It was confirmed that the molecule of nucleosides is complex to such an extent that no linear correlation could be revealed among the respective parameters. Linear correlation was found only in smaller, structurally similar groups of derivatives.
Novotný
L
L
Cancer Research Institute, Bratislava, Czechoslovakia.
Vachálková
A
A
D003561:Cytarabine / Q000737:chemistry*; D003562:Cytidine / Q000031:analogs & derivatives / Q000737:chemistry*; D004247:DNA / Q000096:biosynthesis; D010084:Oxidation-Reduction; D011048:Polarography; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D012995:Solubility
D011741:Pyrimidine Nucleosides; D003561:Cytarabine; D003562:Cytidine; D004247:DNA