[A case of hybrid acute leukemia in a a child].
Hybrid acute leukaemia is characterized by the presence of lymphoid and myeloid markers in a single cell or in different blast cell subpopulations of the same patient. Authors report on a case of a 14-yr-old girl with hybrid acute leukaemia. Immunofluorescent analysis revealed CD 14, CD 10, CD 19 and HLA-DR antigens in the cell suspension isolated from peripheral blood of the patient. Because of the excess of FAB M1 type blast cells, the patient was treated according to IGCI-1984 protocol. Remission was not achieved despite combined cytotoxic treatment and patient died within 4 weeks following admission. The poor outcome of the disease agrees well with literature data. Hybrid acute leukaemia represents a challenge for the clinical science.
Kiss
C
C
Gyermekgyógyászati Klinika, Debreceni Orvostudományi Egyetem.
Kiss
A
A
Kovács
I
I
Oláh
E
E
Balogh
E
E
Karmazsin
L
L
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D003582:Cytogenetics; D006801:Humans; D007150:Immunohistochemistry; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy
Hybrid acut leukaemias gyermek esete.