[Determination of functional "lipid age" on the basis of analysis of serum fatty acids].
The composition of total fatty acids was analyzed in the serum of subjects with normal lipid and glycide metabolism, aged 20 to 89 years. A mathematico-empirical procedure was applied and on using the method of multiple linear regression the formulas of biological function age, designated as lipid age, were established, with individual serum fatty acids and their ratios in relation to characteristic attributes of markers of aging as independent variable parameters. Further correction of lipid age to the chosen level of 60 years was described and the thus corrected lipid age was expressed in percentages. Application of the obtained formulas of lipid age in the series studied showed that the increase rate of lipid age was higher in men by an average of 5.5% compared to women, which represents a difference of 3.8 years. The obtained results demonstrate a significant relationship of fatty acids to the process of aging and their potential use in evaluating processes affecting lipid metabolism.
Bohov
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P
Výskumný ústav gerontológie, Zámocká ulica, Malacky.
Baláz
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V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D005227:Fatty Acids; D008055:Lipids
Urcovanie funkcného "lipidového veku" na základe analýzy mastných kyselín séra.