Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.
By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.
Kang
P J
PJ
Department of Physiological Chemistry, University of Wisconsin, Madison 53706.
Ostermann
J
J
Shilling
J
J
Neupert
W
W
Craig
E A
EA
Pfanner
N
N
D001692:Biological Transport; D002451:Cell Compartmentation; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D005656:Fungal Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D009154:Mutation; D011487:Protein Conformation; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins
D005656:Fungal Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D011498:Protein Precursors; D015800:Protozoan Proteins; C061945:mtp70 protein, Trypanosoma cruzi