title: [A case of mixed connective tissue disease associated with uncommon acute myopathy caused by isolated muscle epithelioid granuloma].
abstract: The patient is 48 year-old female who has been followed as MCTD with nonsteroidal therapies for 18 years. Sometimes she has been attached by focal severe muscle pain. One year ago, she had general myalgia associated with high fever and arthralgia. The results of the examination, aldolase, GOT, GPT, gamma-GTP, CRP and leucocyte were increased. Muscle biopsy showed noncaseating epithelioid granuloma being in contact with enlarged injected vessels. Out of tough with granuloma, a few fibre necroses, fibrosis of muscle, and degeneration of collagen fiber were recognized. After treatment of nonsteroidal antiinflammatory agents, her every complain was removed. Her muscle looks normal herself. MCTD has myopathy caused by inflammatory infiltrates and fibre necroses. But granulomatous myositis is very rare. It is difficult to differentiate our case from sarcoidosis, especially acute isolated muscle sarcoidosis.
authors.affiliation: Department of Dermatology, Yamato City Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: A
authors.initials: A
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
mesh_terms: D000328:Adult; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology