title: The histological and immunohistochemical evidence of squamous metaplasia from the myoepithelial cells in the breast.
abstract: Squamous metaplasia in the breast is well documented. However, the putative cell of origin for the squamous epithelium is not clear. This paper describes a case of fibroadenoma of the breast with myoepithelial hyperplasia and squamous metaplasia. The histological finding of transition between myoepithelial cells and squamous cells and the immunohistochemical expressions of actin and S-100 in the metaplastic squamous cells support the myoepithelial origin of squamous epithelium in the breast.
authors.affiliation: Department of Pathology, National University of Singapore.
authors.forename: G C
authors.initials: GC
authors.lastname: Raju
mesh_terms: D000199:Actins / Q000378:metabolism; D000232:Adenofibroma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D001940:Breast / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D000199:Actins; D009418:S100 Proteins; D014746:Vimentin