Behaviour of tricalcium phosphate and hydroxyapatite granules in sheep bone defects.
Granules of hydroxyapatite (HA) and tricalcium phosphate (TCP) were implanted in separate holes drilled in mandibular bone of sheep to check the bone growth and in vivo behaviour of the materials. The experiment was performed in three sheep, killed respectively at 4, 8, 12 month. Samples of bone with the materials were explanted, microradiographed and sectioned to evaluate the interface under optical and electron scanning electron microscope. The hole, left empty as a reference, showed no full repair; whereas 4 month after implantation the TCP granules induce total repair of the hole. HA granules crumbled and no new bone induction was seen even 12 month after implantation.
Gatti
A M
AM
Laboratory of Biomaterials, School of Dentistry, University of Modena, Italy.
Zaffe
D
D
Poli
G P
GP
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000601:surgery / Q000648:ultrastructure*; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D007568:Jaw / Q000000981:diagnostic imaging; D008422:Materials Testing; D008852:Microradiography; D056948:Orthognathic Surgical Procedures; D019736:Prostheses and Implants; D012756:Sheep; D014463:Ultrasonography
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous