The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus.
The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
Hentall
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ID
University of Illinois, College of Medicine, Rockford 61107-1897.
Budhrani
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VM
D000818:Animals; D004558:Electric Stimulation; D005260:Female; D008636:Mesencephalon / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D011903:Raphe Nuclei / Q000166:cytology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains