Reversal effects of topical retinoic acid on the skin of kidney transplant recipients under systemic corticotherapy.
The systemic long-term corticosteroid treatment administered to kidney graft recipients (KGR) within the framework of the required immunosuppressive therapy induces an atrophy of the skin, from the sixth month onwards. We studied the effect of topical all-trans retinoic acid (0.05%; Galderma Labs.) applied to the forearms of 27 KGR (14 men, 13 women) over a 6-month period. Twenty-four subjects completed the trial. The following results were obtained in the treated forearm versus the untreated forearm (excipient alone): clinically, an increase in skin thickness; by noninvasive techniques, an increase in skin thickness, skin elasticity, skin conductance, and TEWL, and a reduction in the size of the corneocytes. No change in stratum corneum lipid content was observed. A sex-related difference was noted in the response to treatment under our experimental conditions, the female patients responding better. A punch biopsy (4 mm) was performed on both forearms of four patients after the 6-month period. Histologic and ultrastructural examination revealed epidermal and dermal changes evoking increased cellular metabolism in the retinoic acid-treated forearms.
De Lacharriére
O
O
Research Laboratory, L'Oreal-Aulnay Sous Bois, Paris, France.
Escoffier
C
C
Gracia
A M
AM
Teillac
D
D
Saint Léger
D
D
Berrebi
C
C
Debure
A
A
Lévêque
J L
JL
Kreis
H
H
De Prost
Y
Y
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D014212:Tretinoin