An immunohistological study of condylomata acuminata.
Using an indirect immunoperoxidase method and a panel of monoclonal antibodies, anogenital warts removed from 86 individuals (28 heterosexual men, 47 homosexual men and 11 women) were studied. A constant feature was the presence of a stromal infiltrate of lymphocytes, in which CD4+ and CD8+ cells appeared in a ratio of about 5:1. Cells expressing interleukin-2 receptors were found in the stroma, amounting to 10% of the CD3+ cells. Leu 6+ epidermal dendritic cells (Langerhans' cells) were present in each wart; their density and morphology were similar to that in adjacent, apparently normal, skin. The mean number of Langerhans' cells that expressed HLA-DQ was lower than that of HLA-DR + cells. In 40 warts, HLA-DR was expressed on the surface of keratinocytes. Leu 7+ and Leu 11b+ cells were found in the epidermis of 17 and five warts, respectively. B-cells were noted in only five warts. These results are discussed in relation to persistence of wart virus infection.
McMillan
A
A
Department of Medicine, Edinburgh Royal Infirmary, UK.
Bishop
P E
PE
Fletcher
S
S
D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000276:immunology / Q000473:pathology*; D015342:DNA Probes; D005260:Female; D006716:Homosexuality; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000473:pathology; D007801:Langerhans Cells / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012867:Skin / Q000473:pathology
D015342:DNA Probes; D015375:Receptors, Interleukin-2