title: Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man.
abstract: Islet amyloid polypeptide (IAPP) or amylin is a pancreatic islet hormone which was first found in amyloid in insulinomas and in pancreases of patients with type 2 diabetes. In rat a similar polypeptide occurs; however, pancreatic amyloid in this species has not been described. Here we report the structure of the rat and human IAPP gene. Both consist of three exons and two introns which are very similar. The upstream sequence of the rat IAPP gene contains a TATA-box, a CCAAT-sequence and a GT-element, whereas the upstream sequence of the human IAPP gene contains a TATA-box and a rat insulin enhancer-like sequence. This suggests that the rat and human IAPP gene may be controlled differently at the transcriptional level.
authors.affiliation: Laboratory for Physiological Chemistry, University of Utrecht, The Netherlands.
authors.forename: A D
authors.initials: AD
authors.lastname: van Mansfeld
authors.forename: S
authors.initials: S
authors.lastname: Mosselman
authors.forename: J W
authors.initials: JW
authors.lastname: Höppener
authors.forename: J
authors.initials: J
authors.lastname: Zandberg
authors.forename: H A
authors.initials: HA
authors.lastname: van Teeffelen
authors.forename: P D
authors.initials: PD
authors.lastname: Baas
authors.forename: C J
authors.initials: CJ
authors.lastname: Lips
authors.forename: H S
authors.initials: HS
authors.lastname: Jansz
mesh_terms: D000682:Amyloid / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D004742:Enhancer Elements, Genetic; D005091:Exons; D005796:Genes; D006801:Humans; D007328:Insulin / Q000235:genetics; D007438:Introns; D058228:Islet Amyloid Polypeptide; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D016385:TATA Box; D014158:Transcription, Genetic
chemical_list: D000682:Amyloid; D007328:Insulin; D058228:Islet Amyloid Polypeptide