title: Synthetic sialyl glycolipids (sialo-cholesterol and sialo-diglyceride) induce granulocytic differentiation of human myelogenous leukemia cell line HL-60.
abstract: When HL-60 cells were cultivated with synthetic sialyl glycolipids, sialo-cholesterol and sialo-diglyceride, the cells were found to be differentiated into mature granulocytes on morphological and functional criteria. The differentiation of cells was accompanied by inhibition of cell proliferation. The differentiation-inducing activity of sialo-cholesterol was greater than that of sialo-diglyceride on a molar basis, and the alpha-anomer of each compound was more potent than the beta-anomer, suggesting that the stereospecific structure of the compounds is important for the differentiation-inducing activity.
authors.affiliation: Division of Hemopoiesis, Jichi Medical School, Tochigi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Nojiri
authors.forename: H
authors.initials: H
authors.lastname: Ogino
authors.forename: A
authors.initials: A
authors.lastname: Yuo
authors.forename: H
authors.initials: H
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Kitagawa
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004950:Esterases / Q000378:metabolism; D006017:Glycolipids / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D008657:Metabolic Clearance Rate; D010100:Oxygen / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D006017:Glycolipids; C009255:sialoglycolipids; D004950:Esterases; D010100:Oxygen