title: 1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity.
abstract: The structural analogy of paraquat with 1-methyl-4-phenylpyridinium (MPP+) has been implied in the aetiology of Parkinson's disease. The cross-reactivity of MPP+ to a specific antibody to paraquat was assessed by radioimmunoassay and was found to be very low. The results suggest that this polyclonal paraquat antibody does not mimic the MPP+ receptor.
authors.affiliation: INSERM U26, Hôpital Fernand Widal, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Houzé
authors.forename: O
authors.initials: O
authors.lastname: Chappey
authors.forename: H
authors.initials: H
authors.lastname: Gallons
authors.forename: J M
authors.initials: JM
authors.lastname: Scherrmann
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000276:immunology; D015655:1-Methyl-4-phenylpyridinium / Q000737:chemistry / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D003429:Cross Reactions; D006801:Humans; D008968:Molecular Conformation; D010269:Paraquat / Q000737:chemistry / Q000276:immunology*; D011863:Radioimmunoassay
chemical_list: D000906:Antibodies; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D010269:Paraquat; D015655:1-Methyl-4-phenylpyridinium