[Fetal survival after the corticosteroid and low-dose aspirin regimen in a case of anti-phospholipid antibody syndrome].
A 27-year-old woman with anti-phospholipid antibody syndrome, whose first pregnancy had ended in intrauterine fetal death, was treated with prednisolone 0.6 mg/kg/day before second pregnancy. Suppression of anti-cardiolipin antibody activity was rapidly achieved and maintained during the pregnancy. After conception, low-dose aspirin 81 mg/day was started and continued until delivery. She gave birth to a normal live infant with natural full-term delivery. It is strongly suggested that the corticosteroid and low-dose aspirin regimen can lead to successful pregnancy in cases with anti-phospholipid antibody syndrome like the present case.
Shimmyozu
K
K
Third Department of Internal Medicine, Kagoshima University, School of Medicine, Japan.
Okadome
T
T
Maruyama
Y
Y
Maruyama
I
I
Osame
M
M
Tara
M
M
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D001323:Autoantibodies / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D006801:Humans; D010743:Phospholipids / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000276:immunology; D013577:Syndrome
D001323:Autoantibodies; D010743:Phospholipids; D011239:Prednisolone; D001241:Aspirin