title: Macromolecular lactate dehydrogenase: an innocent bystander.
abstract: Lactate dehydrogenase (LD) activity is often increased in malignancy, and may occasionally be a useful tumor marker. In the case reported here, a persistently increased LD activity led to an extensive search for a neoplasm. Results of routine investigations were normal, but LD electrophoresis followed by gel filtration and immunofixation confirmed the presence of a circulating macromolecular LD, comprising IgAK bound to LD. Altogether it may provoke unnecessary investigations, the LD-IgA complex currently has no diagnostic significance.
authors.affiliation: Division of Clinical Chemistry, Institute of Medical and Veterinary Science, Adelaide, South Australia.
authors.forename: G A
authors.initials: GA
authors.lastname: Tallis
authors.forename: J
authors.initials: J
authors.lastname: Bahnisch
authors.forename: D W
authors.initials: DW
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Bais
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D046911:Macromolecular Substances; D008297:Male
chemical_list: D014408:Biomarkers, Tumor; D046911:Macromolecular Substances; D007770:L-Lactate Dehydrogenase