title: Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
abstract: A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.
authors.affiliation: Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: G R
authors.initials: GR
authors.lastname: Clark
authors.forename: D G
authors.initials: DG
authors.lastname: Brown
authors.forename: M R
authors.initials: MR
authors.lastname: Sanderson
authors.forename: T
authors.initials: T
authors.lastname: Chwalinski
authors.forename: S
authors.initials: S
authors.lastname: Neidle
authors.forename: J M
authors.initials: JM
authors.lastname: Veal
authors.forename: R L
authors.initials: RL
authors.lastname: Jones
authors.forename: W D
authors.initials: WD
authors.lastname: Wilson
authors.forename: G
authors.initials: G
authors.lastname: Zon
authors.forename: E
authors.initials: E
authors.lastname: Garman
mesh_terms: D001483:Base Sequence; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D012996:Solutions; D014961:X-Ray Diffraction
chemical_list: D009838:Oligodeoxyribonucleotides; D012996:Solutions