title: Management of superficial G2 (pTa and pT1) bladder cancer.
abstract: A total of 143 patients with superficial G2 (pTa, pT1) bladder cancer (48 G2pTa; 95 G2pT1) presenting between 1970 through 1987 were reviewed. Of 48 patients with G2pTa followed for up to eighteen years, G3 recurrence developed only in 1 (2.0%), and invasive cancer (greater than pT2) developed only in 2 (4.2%). They both received radiotherapy and have responded completely. There have been no cancer-related deaths. In contrast, in the 95 patients in whom the basement membrane had been breached (pT1), higher grade tumor (G3) developed in 11 (11.5%), and 15 (16%) had recurrences with invasion of muscle (greater than pT2). Among these there were 7 (7.3%) cancer-related deaths.
authors.affiliation: Department of Urology, London Hospital, Whitechapel, England.
authors.forename: A C
authors.initials: AC
authors.lastname: Thorpe
authors.forename: B J
authors.initials: BJ
authors.lastname: Jenkins
authors.forename: J E
authors.initials: JE
authors.lastname: Martin
mesh_terms: D002278:Carcinoma in Situ / Q000188:drug therapy / Q000556:secondary; D003131:Combined Modality Therapy; D015653:Cystectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008937:Mitomycins / Q000627:therapeutic use; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*
chemical_list: D008937:Mitomycins