Spermine-like functions of N1, N12-bis(ethyl)spermine: stimulation of protein synthesis and cell growth and inhibition of gastric ulceration.
The spermine analogue N1, N12-bis(ethyl)spermine (BESPM) could mimic the functions of spermine in the following aspects: 1) BESPM could stimulate globin and ornithine decarboxylase synthesis in a rabbit reticulocyte cell-free system; 2) the addition of BESPM to the culture medium could recover cell growth of polyamine-deficient bovine lymphocytes; 3) spermidine uptake by bovine lymphocytes was inhibited by BESPM and spermine to a comparable degree; and 4) stress-induced gastric ulceration was inhibited by subcutaneous administration of BESPM. Since BESPM was less toxic than spermine for mice, BESPM or its derivatives may be useful for diseases which can be cured by polyamines.
Igarashi
K
K
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Kashiwagi
K
K
Fukuchi
J
J
Isobe
Y
Y
Otomo
S
S
Shirahata
A
A
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000235:genetics*; D014176:Protein Biosynthesis; D011817:Rabbits; D051381:Rats; D012156:Reticulocytes / Q000378:metabolism; D013096:Spermine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D013276:Stomach Ulcer / Q000517:prevention & control*; D013315:Stress, Psychological
D000897:Anti-Ulcer Agents; D013096:Spermine; C052614:N(1), N(12)-diethylspermine; D005914:Globins; D009955:Ornithine Decarboxylase