title: Tumor-inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. V. Synthesis and evaluation of enantiomeric [1,2-bis-(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes.
abstract: The enantiomeric [1,2-bis(4-fluorophenyl)ethylenediamine]dichloroplatinum(II) complexes were synthesized and tested on the hormone-sensitive human MCF7 breast cancer cell line and on the P388 leukemia of the mouse. They showed a strong and comparable activity on both tumor models.
authors.affiliation: Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Sonderforschungsbereich 234 (SFB 234), Universität Regensburg, Federal Republic of Germany.
authors.forename: H D
authors.initials: HD
authors.lastname: vom Orde
authors.forename: H
authors.initials: H
authors.lastname: Reile
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Gust
authors.forename: G
authors.initials: G
authors.lastname: Bernhardt
authors.forename: T
authors.initials: T
authors.lastname: Spruss
authors.forename: H
authors.initials: H
authors.lastname: Schönenberger
authors.forename: T
authors.initials: T
authors.lastname: Burgemeister
authors.forename: A
authors.initials: A
authors.lastname: Mannschreck
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C064244:(1,2-bis(4-fluorophenyl)ethylenediamine)dichloroplatinum(II); D002945:Cisplatin