Endothelium-dependent relaxations and chronic vasospasm after subarachnoid hemorrhage.
Endothelium-dependent relaxations are abolished in the canine basilar artery after subarachnoid hemorrhage. However, the release of endothelium-derived relaxing factor (EDRF) toward the lumen is not reduced. These findings suggest that the responsiveness of the smooth muscle to EDRF is impaired during chronic vasospasm after subarachnoid hemorrhage.
Kim
P
P
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn.
Vanhoutte
P M
PM
D000818:Animals; D004195:Disease Models, Animal; D002546:Ischemic Attack, Transient / Q000150:complications*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*
D009569:Nitric Oxide