title: Comparison of a special class of epithelial cells in hyperplastic thyroids undergoing involution and in thyroids in hypophysectomized rats.
abstract: In male Fischer rats, a class of follicles with flat epithelium is present as a minor component of thyroid glands in which most of the follicles have cuboidal epithelium. These follicles occur in thyroids that have been made hyperplastic by feeding the rats thiouracil for 21 days and then allowing involution for 21 days or more. They also occur in older control rats. The follicles resemble in morphology, at the light-microscope level, the so-called "cold" follicles that occur in aged mice. We have examined the ultrastructure of the flat cells in these follicles and compared it with that of the flat cells occurring in the thyroid follicles of hypophysectomized rats. The cells in involution have abundant rough endoplasmic reticulum (RER) and few lysosomes and, in these respects, differ markedly from cells in hypophysectomized rats. The follicles with flat cells are surrounded by a normal incidence of blood capillaries, so that the cells do not appear to be deprived of access to an adequate supply of materials necessary to satisfy their metabolic requirements. Their abundant RER suggests that they have thyroid-stimulating hormone (TSH) receptors, so that the flat cell may be the result of some process occurring at a step distal to receptor coupling with TSH. Their occurrence in young rats after the induction of hyperplasia may be a consequence of cell multiplication producing a clone of neighboring abnormal cells that have an abnormally small cell height.
authors.affiliation: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: O
authors.initials: O
authors.lastname: Tachiwaki
authors.forename: S H
authors.initials: SH
authors.lastname: Wollman
mesh_terms: D000818:Animals; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D006965:Hyperplasia / Q000473:pathology; D007016:Hypophysectomy; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011916:Rats, Inbred F344; D013961:Thyroid Gland / Q000473:pathology* / Q000648:ultrastructure