[Hereditary polymorphism of glutathione-S-transferase in the human liver in normal conditions and in alcoholic hepatitis].
A total of 100 autopsy liver extracts from Russian individuals were examined for glutathione-S-transferase I (GST1) isozymes by means of starch gel electrophoresis. The gene frequencies of GST1* 1, GST1* 2 and GST1* 0 were 0.051, 0.251 and 0.697, respectively. Analysis of data obtained and those in literature for other populations revealed the difference between European and Mongoloid groups. The GST1 0 phenotype was found in samples of liver from individuals with alcoholic hepatitis at frequency 77.3%. The gene frequencies for GST1* 1, GST1* 2 and GST1* 0 were 0.020, 0.100 and 0.879, respectively.
Afanas'eva
I S
IS
Spitsyn
V A
VA
D005982:Glutathione Transferase / Q000235:genetics*; D006519:Hepatitis, Alcoholic / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D011110:Polymorphism, Genetic; D012016:Reference Values
D007527:Isoenzymes; D005982:Glutathione Transferase
Nasledstvennyĭ polimorfizm glutation-S-transferazy pecheni cheloveka v norme i pri alkogol'nom gepatite.