title: Depressant effect of raphe stimulation on inspiratory activity of the hypoglossal nerve: in vitro study in the newborn rat.
abstract: Respiratory activity was recorded from the hypoglossal nerve and cervical ventral roots of the superfused isolated brainstem and spinal cord of the newborn rat in order to investigate the effects of serotonin (5-HT). Three experimental procedures were used: (i) brainstem superfusion by exogenous 5-HT (previously reported), (ii) electrical stimulation of pontine midline structures, and (iii) pressure microejection of L-glutamate at the same sites. Each of the experimental procedure increased respiratory frequency and depressed the amplitude of the discharge of the hypoglossal nerve more than that of the cervical roots. These results indicate that 5-HT acts centrally to modulate the activity of the respiratory generator and inhibits the hypoglossal activity. A possible involvement of 5-HT mediated inhibition in obstructive apnea is discussed.
authors.affiliation: Département de Physiologie et Neurophysiologie, Faculté des Sciences et Techniques St Jérome, Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Morin
authors.forename: S
authors.initials: S
authors.lastname: Hennequin
authors.forename: R
authors.initials: R
authors.lastname: Monteau
authors.forename: G
authors.initials: G
authors.lastname: Hilaire
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004558:Electric Stimulation; D007002:Hypoglossal Nerve / Q000502:physiology*; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D011149:Pons; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012119:Respiration / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D012702:Serotonin Antagonists; D008784:Methysergide