Effect on human liver glycosidases and short syntheses of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine from D-glycero-D-gulo-heptono-1,4-lactone.
The synthesis of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine (1) from D-glycero-D-gulo-heptono-1,4-lactone (6) by two different routes is reported. The effects of 1 on the inhibition of 15 human liver glycosidases are described.
Collin
W F
WF
Dyson Perrins Laboratory, Oxford University, UK.
Fleet
G W
GW
Haraldsson
M
M
Cenci di Bello
I
I
Winchester
B
B
D055598:Chemical Phenomena; D002621:Chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*
D011758:Pyrroles; C065904:1,2,6,7-tetrahydroxypyrrolizidine; D006026:Glycoside Hydrolases