Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man.
The effect of long-term administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids was determined using the tauro 23 (75Se) selena-25 homotaurocholic acid test in a controlled double-blind study involving healthy subjects (n = 15). Subjects received placebo or 13 to 15 mg/kg/day ursodeoxycholic acid for 5 wk. In the placebo group (n = 7) there was no change in the composition of serum bile acids or in the mean percentage of retention of tauro 23(75Se) selena-25 homotaurocholic acid (36.1% +/- 6.0% vs. 38.7% +/- 6.7%). In contrast, in the ursodeoxycholic acid group, serum ursodeoxycholic acid conjugates increased and the percentage of retention of tauro 23 (75Se) selena-25 homotaurocholic acid fell from 45.8% +/- 6.8% to 20.5% +/- 5.7% (p less than 0.01). We conclude that ursodeoxycholic acid administration reduces ileal absorption of endogenous bile acids. These findings provide a rational explanation for the changes in the composition of the bile acid pool during ursodeoxycholic acid therapy and could have important therapeutic implications.
Marteau
P
P
Hôpital Saint-Antoine, Paris, France.
Chazouilléres
O
O
Myara
A
A
Jian
R
R
Rambaud
J C
JC
Poupon
R
R
D000042:Absorption; D000328:Adult; D001647:Bile Acids and Salts / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013656:Taurocholic Acid / Q000031:analogs & derivatives; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000097:blood / Q000494:pharmacology*
D001647:Bile Acids and Salts; D013656:Taurocholic Acid; D014580:Ursodeoxycholic Acid; C033638:23-seleno-25-homotaurocholic acid