[Anti-inflammatory effects of liposomes].
Studies of antiexudative, antialterative, and antibacterial effects of lecithin-cholesterol liposomes suggest their possible use as antiinflammatory agents. It is shown that incubation of liposomes with opportunistic microorganisms is attended with a pronounced antibacterial effect, while subcutaneous injection of liposomes significantly reduces the soft tissue edema caused by administration of formalin, and prevents pronounced alteration in response to acetic acid solution. A conclusion is derived on the possibility to use the membranotropic properties of liposomal membranes to alleviate manifestations of inflammation.
Kreĭnes
V M
VM
Mel'nikova
V M
VM
Margolin
Ia M
IaM
Mel'iantseva
L P
LP
Gladshteĭn
A I
AI
Andriasian
B A
BA
D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects; D005557:Formaldehyde; D006614:Hindlimb; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007279:Injections, Subcutaneous; D008081:Liposomes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013211:Staphylococcus aureus / Q000187:drug effects
D008081:Liposomes; D010713:Phosphatidylcholines; D005557:Formaldehyde; D002784:Cholesterol
Protivovospalitel'nye éffekty liposom.