title: Improved therapeutic index of cisplatin analogue: B-85-0040 by circadian timing.
abstract: 1. B-85-0040 is a new cisplatin analogue with dose limiting myelosuppression. 2. The maximum tolerated dose ranges between 300 and 525 mg/kg for single i.p. bolus injection in mice. 3. Its toxicity is circadian-stage dependent with optimal tolerance between 16 and 17 hours after lights on. 4. B-85-0040 is active in L1210 leukemia. Anti-tumor activity seems to be unrelated to the circadian stage of treatment. Optimal drug timing can therefore increase its therapeutic index.
authors.affiliation: Med. Oncology Div., Albany Medical College, NY.
authors.forename: R
authors.initials: R
authors.lastname: von Roemeling
authors.forename: E
authors.initials: E
authors.lastname: Portuese
authors.forename: M
authors.initials: M
authors.lastname: Salzer
authors.forename: O
authors.initials: O
authors.lastname: Solis
authors.forename: J
authors.initials: J
authors.lastname: Bennett
authors.forename: R
authors.initials: R
authors.lastname: Sothern
authors.forename: D
authors.initials: D
authors.lastname: Hoffmann
authors.forename: H
authors.initials: H
authors.lastname: Sedlacek
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002940:Circadian Rhythm; D002945:Cisplatin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA
chemical_list: C066002:B 85-0040; D002945:Cisplatin