title: Estimation of hepatic blood flow in branches of hepatic vessels utilizing a noninvasive, duplex Doppler method.
abstract: The measurement of hepatic blood flow by indirect methods such as indocyanine green clearance has several limitations. The duplex Doppler offers the potential for noninvasive, real-time measurement of blood flow and has been employed in the evaluation of arterial disease in a variety of vascular beds. We evaluated Doppler ultrasound estimation of blood flow in branches of the hepatic artery, hepatic vein, and portal vein in 12 healthy subjects on two separate days. In vitro accuracy of the scanner was assessed using phantom targets of known diameter and velocity. Blood velocity and vessel diameter measurements were obtained five times over a period of 2 hours. No significant differences were seen in velocity or blood flow measurements within or between days. The interday coefficients of variation, which include intrasubject variability, were 10-15% and 14-20% for velocity and blood flow measurements, respectively. This study demonstrates the potential utility of Doppler ultrasound to detect intrinsic, drug, or disease-induced changes in hepatic blood flow.
authors.affiliation: Department of Pharmacy Practice, School of Pharmacy, University of Washington, Seattle 98195.
authors.forename: J R
authors.initials: JR
authors.lastname: Horn
authors.forename: B
authors.initials: B
authors.lastname: Zierler
authors.forename: L A
authors.initials: LA
authors.lastname: Bauer
authors.forename: W
authors.initials: W
authors.lastname: Reiss
authors.forename: D E
authors.initials: DE
authors.lastname: Strandness
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D005260:Female; D006499:Hepatic Artery / Q000502:physiology*; D006503:Hepatic Veins / Q000502:physiology*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D011169:Portal Vein / Q000502:physiology*; D015203:Reproducibility of Results; D013997:Time Factors; D014465:Ultrasonics
chemical_list: D007208:Indocyanine Green