Long-term effect of ACTH treatment of relapse in multiple sclerosis.
A controlled, randomized study of the long-term effects of ACTH-treatment (100 units intramuscular, tapered over 12 weeks) of acute relapse in 29 MS patients was performed. Follow-up lasted one year. In some Kurtzke Functional System, the Ambulation Index and the Kurtzke Incapacity Scale a transient greater improvement in the ACTH-treated patients was observed. These superior results in the ACTH group were no longer present at 6 months. Significantly more side-effects were reported in the ACTH-group. After treatment with ACTH a higher, though not statistically significant, relapse rate in the following months was noticed.
Hoogstraten
M C
MC
Department of Neurology, University Hospital, Groningen, The Netherlands.
Minderhoud
J M
JM
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009420:Nervous System / Q000503:physiopathology; D009460:Neurologic Examination; D012008:Recurrence