title: [ADP-induced aggregation of human platelets in diabetes mellitus].
abstract: Dilution of thrombocyte-rich blood plasma (down to 2.5 x 10(8) thrombocytes/ml) enabled to avoid an irreversible phase of the ADP-induced thrombocyte aggregation; the reversible phase of aggregation was followed by deaggregation. The reversible aggregation of thrombocytes was studied in healthy persons and patients with diabetes mellitus within wide ranges of ADP concentrations (including 10 microM) using the diluted blood plasma. Thrombocytes of the patients with diabetes mellitus of the I and II types were found to be 1.6- and 2.33-fold more sensitive to the ADP aggregating effect as compared with thrombocytes of healthy persons. The elevated rate of thrombocytes aggregation in diabetes mellitus appears to be related to early decrease in activity of thrombocyte guanylate cyclase and to its ability to be activated.
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Chirkov
authors.forename: I A
authors.initials: IA
authors.lastname: Tyshchiuk
authors.forename: I S
authors.initials: IS
authors.lastname: Severina
authors.forename: L K
authors.initials: LK
authors.lastname: Starosel'tseva
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D000244:Adenosine Diphosphate
vernacular_title: ADF-indutsiruemaia agregatsiia trombotsitov cheloveka pri sakharnom diabete.