title: Efficacy against ovine enzootic abortion of an experimental vaccine containing purified elementary bodies of Chlamydia psittaci.
abstract: A vaccine prepared from purified, inactivated elementary bodies of Chlamydia psittaci protected sheep against abortion after subcutaneous challenge with live chlamydiae. Immunoblot analysis of serum samples revealed a consistently dominant antibody response against the chlamydial major outer membrane protein in all vaccinated sheep. Reactions to other chlamydial antigens were also detected but were less pronounced or inconsistent. Serological responses detected by complement fixation were variable and did not correlate with immunity.
authors.affiliation: Moredun Research Institute, Edinburgh, Great Britain.
authors.forename: I E
authors.initials: IE
authors.lastname: Anderson
authors.forename: T W
authors.initials: TW
authors.lastname: Tan
authors.forename: G E
authors.initials: GE
authors.lastname: Jones
authors.forename: A J
authors.initials: AJ
authors.lastname: Herring
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001428:Bacterial Vaccines; D002691:Chlamydophila psittaci / Q000276:immunology*; D003168:Complement Fixation Tests; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D015151:Immunoblotting; D011247:Pregnancy; D009956:Psittacosis / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines