title: [Hemodynamics and its control in patients with thyrotoxicosis and in healthy persons according to the data of anapriline and graded exercise tests].
abstract: The study was undertaken to examine effects of anapriline on bicycle ergometric and echocardiographic parameters and catecholamine excretion in 17 patients with thyrotoxicosis and 21 healthy subjects. A single dose of anapriline contributed to transition of hyperkinetic central hemodynamics to eukinetic one and a more saving regimen of heart performance at rest and submaximal exercise levels in the healthy subjects. In contrast, the patients maintained hyperkinetic hemodynamics and had a high energy demand during exercise and showed a reduction in left ventricular systolic and diastolic function and a significant decrease in catecholamine excretion. Disintegration of regulatory mechanisms in thyrotoxicosis was found to be due to the function interrelationship between thyroid hormones and catecholamines.
authors.forename: E I
authors.initials: EI
authors.lastname: Sokolov
authors.forename: A P
authors.initials: AP
authors.lastname: Zaev
authors.forename: R P
authors.initials: RP
authors.lastname: Ol'kha
authors.forename: S A
authors.initials: SA
authors.lastname: Zhizhina
authors.forename: T P
authors.initials: TP
authors.lastname: Khovanskaia
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000097:blood; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011433:Propranolol; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000097:blood / Q000503:physiopathology*
chemical_list: D002395:Catecholamines; D013963:Thyroid Hormones; D011433:Propranolol
vernacular_title: Gemodinamika i ee reguliatsiia u bol'nykh tireotoksikozom i zdorovykh lits po dannym prob s anaprilinom i dozirovannoĭ fizicheskoĭ nagruzkoĭ.