title: [The antitumor effect of an extract of human umbilical cord].
abstract: The study was concerned with the evaluation of effect of the extract of a human fetal organ, the umbilical cord, on development and growth of such transplantable tumors as Ehrlich's ascites tumor, sarcoma 37, sarcoma 180 and Zajdela's hepatoma as well as of dimethylbenzanthracene- and benzo(a)pyrene-induced cancer. In a subgroup of animals who had been vaccinated once or twice prior to inoculation of cells, a significant inhibition of growth of tumors of all the histologies except sarcoma 180 was observed alongside with a decrease in tumor incidence and partial resorption of ascitic fluid. Preliminary vaccination of rats interfered with dimethylbenzanthracene- and benzo(a)pyrene-induced carcinogenesis reducing tumor incidence and assuring longer latent period and slower progression of cancer.
authors.forename: L N
authors.initials: LN
authors.lastname: Mkrtchian
authors.forename: E R
authors.initials: ER
authors.lastname: Ter-Pogosian
authors.forename: A K
authors.initials: AK
authors.lastname: Nersesian
authors.forename: E V
authors.initials: EV
authors.lastname: Petanova
authors.forename: S O
authors.initials: SO
authors.lastname: Martirosian
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D014020:Tissue Extracts / Q000276:immunology*; D014470:Umbilical Cord; D014611:Vaccination
chemical_list: D014020:Tissue Extracts
vernacular_title: Protivoopukholevoe deĭstvie ékstrakta pupoviny chelovecheskogo ploda.