title: Ultrastructural aspects of the human peripheral vestibular system.
abstract: The sensory epithelia from the membranous labyrinths of 4 patients were examined by transmission electron microscopy. The distribution ratio of type 1 to type 2 cells was recorded, compared for each sensory area and correlated with age. An ultrastructural assessment confirmed generalized patterns consistent with autolytic and preparation artefact, viz. calyceal dilatation, cytoplasmic protrusions and some sensory hair loss. More specific features, i.e. lipofuscin accumulation, membrane-bound inclusions and neural degeneration were consistent with pre-mortem pathological change. In 2 patients, total nerve fibre counts of 15,766 and 19,741 were obtained. Total fibre counts correlated with the sensory cell density of the innervated areas. Differential counts of the superior and inferior vestibular nerves suggested that there was a reduced number of fibres in the superior division of both patients, in comparison with established normative data. Morphometric analysis of the constituent fibre diameters revealed a skewed distribution with a modal value of 6 microns for both patients.
authors.affiliation: Department of Surgery, Guy's Hospital, London.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gleeson
authors.forename: H
authors.initials: H
authors.lastname: Felix
authors.forename: L G
authors.initials: LG
authors.lastname: Johnsson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D012444:Saccule and Utricle / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000648:ultrastructure*