title: [Cultured epidermis in the treatment of leg ulcer: "edge effect" and correlation with keratinocyte proliferation index].
abstract: Cultured keratinocyte grafting (KG) of chronic leg ulcers produces an impressive stimulation of host epithelization by an effect on the edge of the ulcer, which starts to grow in rapidly ("edge effect"). In 5 patients with chronic leg ulcers treated by KG, we have studied the proliferation index of the epidermis of the edge and of the graft area and that of secondary culture keratinocytes. The aim of the study was to correlate this parameter with the clinical evolution of the treated lesions. We found a significant correlation between the proliferation index of the edge epidermis and the clinical evidence of "edge effect".
authors.affiliation: Chirurgia Plastica e Ricostruttiva, Università di Firenze.
authors.forename: V
authors.initials: V
authors.lastname: Giannotti
authors.forename: N
authors.initials: N
authors.lastname: Pimpinelli
authors.forename: V
authors.initials: V
authors.lastname: Mariotti
authors.forename: L
authors.initials: L
authors.lastname: Borgognoni
authors.forename: U M
authors.initials: UM
authors.lastname: Reali
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D002478:Cells, Cultured; D002908:Chronic Disease; D004817:Epidermis / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D007871:Leg Ulcer / Q000601:surgery*; D008875:Middle Aged; D013997:Time Factors
vernacular_title: L'epidermide espansa in coltura nel trattamento dell'ulcus cruris: "effetto bordo" e correlazione con l'indice di proliferazione dei cheratinociti.