Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1. The present paper describes further mapping of the AT locus by means of a panel of 10 markers that span approximately 60 cM in the 11q22-23 region centered around S144 and THY1. Location scores indicate that three contiguous subsegments within the [S144-THY1] segment, as well as three contiguous segments telomeric to THY1, are each unlikely to contain the AT locus, while the more centromeric [STMY-S144] segment is most likely to contain the AT locus. These data, together with recent refinements in the linkage and physical maps of 11q22-23, place the AT locus at 11q23.
Sanal
O
O
Department of Pathology, University of California, Los Angeles 90024.
Wei
S
S
Foroud
T
T
Malhotra
U
U
Concannon
P
P
Charmley
P
P
Salser
W
W
Lange
K
K
Gatti
R A
RA
D000483:Alleles; D001260:Ataxia Telangiectasia / Q000235:genetics*; D002503:Centromere / Q000648:ultrastructure; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree
D005819:Genetic Markers