The circadian rhythm of intact parathyroid hormone-(1-84): temporal correlation with prolactin secretion in normal men.
Serum PTH-(1-84), PRL, and adjusted calcium concentrations were determined at 30-min intervals for a 24-h period in six normal adult men. PTH-(1-84) and PRL both exhibited two peaks of increased secretion [1600-1900 and 0200-0600 h for PTH-(1-84); 2000-2200 and 0400-0800 h for PRL]. For each subject there was a striking similarity in the magnitude of secretion of the two hormones and a consistent temporal relationship. Thus, the maximum correlation coefficients of 0.62-0.83 were obtained for the six subjects when the PRL surge lagged that of PTH-(1-84) by 0.5-3.5 h. In contrast, the correlation between PTH-(1-84) and adjusted calcium was weaker (r = -0.36 to -0.66) and showed no consistent temporal relationship (0.0-10.5 h). These data support the concept of higher center control of PTH-(1-84) secretion with the possible involvement of factors common to the control of PRL secretion.
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F C
FC
Institute of Biochemistry, Royal Infirmary, Glasgow, United Kingdom.
Fraser
W D
WD
O'Reilly
D S
DS
Cameron
D A
DA
Kelly
A J
AJ
Beastall
G H
GH
D000328:Adult; D002118:Calcium / Q000097:blood; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012016:Reference Values
D010281:Parathyroid Hormone; D011388:Prolactin; D002118:Calcium