Minimal bactericidal and inhibitory concentrations of ofloxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications.
Mycobacterium fortuitum infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs in vitro of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under in vivo settings.
Yew
W W
WW
Tuberculosis and Chest Unit, Grantham Hospital, Aberdeen, Hong Kong.
Kwan
S Y
SY
Ma
W K
WK
Lui
K S
KS
D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests / Q000379:methods; D009170:Nontuberculous Mycobacteria / Q000187:drug effects* / Q000254:growth & development; D015242:Ofloxacin / Q000494:pharmacology*
D003470:Culture Media; D015242:Ofloxacin