An immunohistological study of the human enteric nervous system with microtubule-associated proteins.
Immunohistochemical study of normal intestines from six infants and children with monoclonal antibodies against microtubule-associated proteins showed that microtubule-associated proteins 5 and tau were excellent markers of the enteric nervous system. Compared with neuron-specific enolase, microtubule-associated proteins 5 and tau had similar distribution but gave more cellular details showing a cytoskeleton of microtubules in neuroplasm. Unlike S100 protein, microtubule-associated proteins 5 and tau were neuron specific and were absent from glial cells. More enteric neurons contained microtubule-associated proteins 5 and tau than neurofilament proteins. Of the other microtubule-associated proteins, microtubule-associated protein 2 was present in only a few enteric neurons and microtubule-associated protein 1 was entirely absent.
Tam
P K
PK
Institute of Child Health, University of Liverpool, Royal Liverpool Children's Hospital, England.
D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000294:innervation; D008856:Microscopy, Fluorescence; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000378:metabolism
D008869:Microtubule-Associated Proteins