title: Neural influence on the action of insulin in the adrenomedullary catecholamine content in the pigeon.
abstract: Insulin-induced (4 IU/100 g b.wt.) changes of adrenomedullary catecholamines (CA) were investigated in unilaterally splanchnic denervated pigeons 0.5, 4, 12, 24, 72, 144 and 216 h after injection. Insulin caused depletion of more norepinephrine (NE) from the denervated glands 0.5 h after treatment. This indicates that the splanchnic nerve prevents early phase of insulin-induced depletion of NE. Accelerated resynthesis of NE exceeding the control value was more in the innervated glands 24 h after administration. Insulin brought about augmented synthesis of epinephrine (E) surpassing the control value in the innervated glands 72 h after treatment. The findings point out that the splanchnic nerve stimulates resynthesis of NE and synthesis of E induced by insulin.
authors.affiliation: Department of Pharmacology, University of Innsbruck, Austria.
authors.forename: S K
authors.initials: SK
authors.lastname: Mahata
authors.forename: A
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000311:Adrenal Glands / Q000294:innervation; D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D010856:Columbidae / Q000378:metabolism*; D003714:Denervation; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009424:Nervous System Physiological Phenomena; D009638:Norepinephrine / Q000378:metabolism*
chemical_list: D007328:Insulin; D009638:Norepinephrine; D004837:Epinephrine