[Comparison of plasmatic and renal clearance of lithium].
The authors elaborated a method for assessment of the renal lithium clearance, CLr, the results of which correlate well with the plasmatic clearance (CLp] (r = 0.785, p less than 0.05). This correlation improved substantially after correction of CLr to the clearance of endogenous creatinine, CLcr (r = 0.945; p less than 0.05). The mean values of CLr of the investigated group--26.4 ml/min are in agreement with the results published by other authors. A significant correlation between CLr and CLcr (r = 0.826, p less than 0.05) along with comparison of the intraindividual variability of assessed results indicates that it is better to use as a parameter of sodium absorption from the proximal tubule the fractional lithium clearance rather than absolute values of CLr.
Pospísil
J
J
I. interní katedra 1. lékarské fakulty, Univerzity Karlovy, Praha.
Merta
M
M
Koubek
J
J
D000328:Adult; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics*
D008094:Lithium
Srovnání plazmatické a renálni clearance lithia.