title: [Intestinal perforation occurring at the beginning of treatment: a severe complication of bacillary tuberculosis].
abstract: We report 2 cases of intestinal perforation caused by tuberculosis and affecting the small intestine in one case and the colon in the other case. The patients were men aged 49 and 51 years respectively. Both were cachectic and presented with advanced open pulmonary tuberculosis. Perforation in free peritoneal cavity occurred 2 and 8 days respectively after an antituberculous treatment was initiated. The outcome was rapidly fatal in both cases. Tuberculous enteritis has become rare, but it can still be observed in patients with severe open pulmonary tuberculosis, where the gastro-intestinal tract is contaminated by the large number of virulent mycobacteria swallowed. In such patients clinicians must be alert to abdominal premonitory signs. Intestinal perforations in free peritoneal cavity are uncommon. Most perforation are small, single or multiple, and located on the antimesenteric side of the terminal ileum. They may occur at any time, and particularly just after an antituberculous therapy has been instituted. Clinical presentation is one of acute peritonitis requiring emergency laparotomy. Mortality has been reduced by technical improvements, notably temporary enterostomy, but perforation remains a serious and often fatal complication of tuberculosis in patients with severe malnutrition.
authors.affiliation: Service de Pneumologie, CHU de Poitiers.
authors.forename: P
authors.initials: P
authors.lastname: Doré
authors.forename: J C
authors.initials: JC
authors.lastname: Meurice
authors.forename: J
authors.initials: J
authors.lastname: Rouffineau
authors.forename: M
authors.initials: M
authors.lastname: Carretier
authors.forename: P
authors.initials: P
authors.lastname: Babin
authors.forename: J
authors.initials: J
authors.lastname: Barbier
authors.forename: F
authors.initials: F
authors.lastname: Patte
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D003106:Colon; D004766:Enterostomy; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D007421:Intestine, Small; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011859:Radiography; D014385:Tuberculosis, Gastrointestinal / Q000150:complications* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents
vernacular_title: Perforations intestinales survenant en début de traitement: une complication grave des tuberculoses bacillifères.