[A model of experimental acute pancreatitis in the conscious rat].
We describe an experimental model of acute pancreatitis in conscious rats, based on biliary reflux; sodium deoxycholate was injected while maintaining the common duct (biliary and pancreatic) temporally occluded. A progressive increase of serum amylase, cardiac rate and hematocrit value, as well as a decrease of plasma proteins are characteristic of this experimental model. Blood pressure was maintained until shortly before death, which occurred after 85 minutes. This is a simple model, reliable and reproducible, which requires minimal surgical manipulation.
Ais Conde
J G
JG
Servicio de Cirugía de Aparato Digestivo, Fundación Jiménez Díaz-CSIC, Universidad Autónoma de Madrid.
López Novoa
J M
JM
Novo Alonso
C
C
Romeo Martínez
J M
JM
D000208:Acute Disease; D000818:Animals; D003135:Common Bile Duct / Q000502:physiology; D003840:Deoxycholic Acid; D004195:Disease Models, Animal; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D003840:Deoxycholic Acid
Modelo de pancreatitis aguda experimental en la rata consciente.