Effects of low dose guar in non-insulin dependent diabetic patients.
Thirteen non-obese, non-insulin-dependent diabetic patients were given guar granulate in an average dose of 7.1 grams daily for 8 weeks. The mean fructosamine fell from 3.3 +/- 0.69 mmol/L (p less than 0.01). Mean glycosylated haemoglobin (HbA1c) fell from 8.17 +/- 2.2% preguar to 7.67 +/- 1.81% (1 = ns) and to 7.39 +/- 1.23% (p = ns) at 8 weeks and 12 weeks postguar respectively. Eight weeks after the discontinuation of guar fructosamine rose to 3.61 +/- 0.95 mmol/L (p less than 0.05) while HbA1c rose to 8.23 +/- 2.08% (p = 0.05). There were no significant changes in fasting blood glucose, lipids, and body weight. Mild gastrointestinal side-effects occurred in 11 patients during the treatment with guar. It is concluded that daily ingestion of low dose guar modestly improves glycaemic control, such improvement dissipating by 8 weeks following cessation of its use.
Lim
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HS
Department of Medicine, Singapore General Hospital.
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D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D005215:Fasting / Q000097:blood; D005260:Female; D019270:Fructosamine; D005685:Galactans / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008297:Male; D008351:Mannans / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D053149:Plant Gums; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D019270:Fructosamine; D005685:Galactans; D006442:Glycated Hemoglobin; D006595:Hexosamines; D008351:Mannans; D053149:Plant Gums; D014280:Triglycerides; C007894:guar gum