[The effects of various drugs and immune complexes on the function of alveolar macrophages from patients with collagen-vascular diseases with interstitial pneumonia].
Alveolar macrophages (AM) taken from sixteen patients with collagen-vascular diseases with interstitial pneumonia (CVD-IP+) were cultured with prednisolone (PSL), prostaglandin E2 (PGE2), colchicine (Colch), D-penicillamine or aggregated IgG (agg-IgG). The culture supernatants were tested on the fibroblast proliferation function and the amounts of fibronectin (Fn) and interleukin 1 (IL-1). The fibroblast proliferation was suppressed significantly by the supernatants of AM cultured with PGE2. The Fn production by AM was significantly suppressed by PGE2 and Colch. The IL-1 production by AM was not suppressed by these drugs, but was enhanced by Colch. In five patients with CVD-IP+, the fibroblast proliferation of AM supernatant was enhanced by agg-IgG. In these five patients, Fn and IL-1 production had a tendency to be increased by agg-IgG. The ratio of immune complexes (IC) in broncho alveolar lavage fluids to those in sera was significantly higher in patients with CVD-IP+ than in patients with CVD without IP suggesting a local production of IC in the lung in the patients with CVD-IP+.
Saito
Y
Y
Second Department of Internal Medicine, Fukushima Medical College.
D000328:Adult; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D003095:Collagen Diseases / Q000150:complications*; D005260:Female; D005346:Fibroblast Growth Factors / Q000096:biosynthesis; D005353:Fibronectins / Q000096:biosynthesis; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000166:cytology; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*
D005353:Fibronectins; D007074:Immunoglobulin G; D007375:Interleukin-1; D011458:Prostaglandins E; D005346:Fibroblast Growth Factors; D011239:Prednisolone; D003078:Colchicine