Chromosome 14: a breakpoint in non-Hodgkin's lymphomas.
In non-Hodgkin's lymphoma, chromosome abnormalities are found that are characteristic for the type of the lymphoma. These chromosomal abnormalities provide a tumour-specific marker and seem to play a role in the oncogenesis of the lymphoma. Chromosome 14 is involved in many lymphomas. The immunoglobulin heavy chain gene and the alpha and delta chain genes for the T cell receptor are located on this chromosome, genes which are essential for the function of B or T lymphocytes. These genes are involved in the specific translocations seen in non-Hodgkin's lymphoma. Their role and the role of oncogenes in the oncogenesis of non-Hodgkin's lymphoma are discussed. The oncogene tcl-1 is also located on chromosome 14.
van 't Veer
M B
MB
Dr. Daniel den Hoed Cancer Centre, Rotterdam.
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002883:Chromosomes, Human, Pair 14; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009857:Oncogenes / Q000235:genetics; D014178:Translocation, Genetic