title: [The use of pharmacological screening for characterizing the toxicity of pertussis vaccines].
abstract: The influence of pertussis preparations, introduced by oral and parenteral routes, on the detoxifying function of the liver and the state of the nervous system of the animals was studied by methods used in pharmacology and toxicology. The use of these methods made it possible to find out side effects produced by corpuscular pertussis vaccine, introduced parenterally, on the detoxifying function of the liver and the state of the nervous system of the animals. The negative influence on the nervous system was more pronounced after the injection of the commercial adsorbed diphtheria-pertussis-tetanus vaccine used in this investigation than after the injection of pertussis monovaccine. The oral administration of corpuscular pertussis vaccine exerted no negative influence on the above-mentioned body functions of the animals.
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Koval'skaia
authors.forename: N A
authors.initials: NA
authors.lastname: Ozeretskovskiĭ
authors.forename: I B
authors.initials: IB
authors.lastname: Shepeleva
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: A N
authors.initials: AN
authors.lastname: Lobanova
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine
vernacular_title: Ispol'zovanie farmakologicheskogo skrininga dlia kharakteristiki toksichnosti kokliushnykh vaktsin.