Effects of bestatin on the host immunity in patients treated for urogenital cancer.
To examine effects of bestatin on the host immunity of patients with urogenital cancer, 54 patients were randomized into 2 groups: bestatin treated and controls. In each group, the patients were divided into 2 subgroups: one which received basic treatment expected to greatly affect host immunity ('invasive treatment') while the other one received other types of basic treatment ('non-invasive treatment'). Peripheral lymphocyte, OKT 4/8 ratio and purified protein derivative (PPD) skin reaction were used as immunological markers. There were significant differences in the 'invasive' treatment group between bestatin treated patients and controls concerning lymphocyte counts and PPD skin reactions and in the 'non-invasive' group concerning lymphocyte counts and OKT 4/8 ratios. These results suggest that bestatin may potentiate host immunity in patients with urogenital cancer. Further studies on larger materials are, however, needed before more definite conclusions can be drawn.
Ozono
S
S
Department of Urology, Nara Medical University, Japan.
Iwai
A
A
Babaya
K
K
Hiramatsu
T
T
Yoshida
K
K
Yamada
K
K
Hirao
Y
Y
Aoyama
H
H
Ohara
S
S
Okajima
E
E
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D014373:Tuberculin / Q000276:immunology; D014565:Urogenital Neoplasms / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D014373:Tuberculin; D007930:Leucine; C012211:ubenimex