Lovastatin. Warfarin interaction.
Two patients who developed hypoprothrombinemia and bleeding due to lovastatin-warfarin drug interaction are described. Because of the wider use of lovastatin and warfarin, heightened clinical awareness of this potentially serious interaction must be publicized. Therefore, prothrombin time should be monitored diligently when warfarin is prescribed to patients receiving lovastatin.
Ahmad
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Cardio-Diagnostic Clinique, Fairmont, WVa 26554.
D001281:Atrial Fibrillation / Q000188:drug therapy; D004347:Drug Interactions; D004844:Epistaxis / Q000139:chemically induced*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006417:Hematuria / Q000139:chemically induced*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy; D008148:Lovastatin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014859:Warfarin / Q000494:pharmacology* / Q000627:therapeutic use
D014859:Warfarin; D008148:Lovastatin