Participation of granulocyte-macrophage colony stimulating factor, interleukin-1 and dendritic cells in concanavalin A-induced T cell responses in human.
The effects of IL-1 and GM-CSF on accessory function of macrophages and dendritic cells (DC) in Con A-induced T cell responses were investigated. The accessory cells were separated from adherent cells of human peripheral mononuclear cells. The accessory function of DC was found to be stronger than that of macrophages. IL-1 and GM-CSF significantly enhanced the T cell responses by augmenting the accessory function of DC in a dose-dependent manner (p less than 0.01), whereas these monokines produced no augmentative effects on macrophages, nor facilitated T cell responses without DC.
Akiyama
Y
Y
Second Department of Internal Medicine, Saitama Medical School.
D000328:Adult; D000938:Antigen-Presenting Cells / Q000502:physiology*; D003208:Concanavalin A / Q000494:pharmacology*; D003713:Dendritic Cells / Q000502:physiology*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology*; D008297:Male; D011994:Recombinant Proteins; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology
D007375:Interleukin-1; D011994:Recombinant Proteins; D003208:Concanavalin A; D016178:Granulocyte-Macrophage Colony-Stimulating Factor