Ph chromosome in a patient with non-leukemic non-Hodgkin B-cell lymphoma.
A standard Philadelphia translocation, t(9;22) (q34;q11), was found in lymph node cells from a patient with non-leukemic non-Hodgkin lymphoma at the time of diagnosis. The rearrangement of the breakpoint cluster region (bcr) was not detected with a bcr-3' probe. The neoplastic clone was of monoclonal B-cell character with E-, CD5-, CD10-, CD13-, CD19+, CD20+, CD21+, CD25-, HLA DR+, and positive surface Ig(kappa). The patient showed no evidence of chronic myelogenous leukemia.
Fujii
H
H
Third Department of Internal Medicine, Kyoto First Red Cross Hospital, Japan.
Yashige
H
H
Misawa
S
S
Tanaka
S
S
Urata
Y
Y
Matuyama
F
F
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007621:Karyotyping; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D015703:Antigens, CD; D006684:HLA-DR Antigens; D007136:Immunoglobulins