title: Cellular reactions on heparin surface-modified versus regular PMMA lenses during the first postoperative month. A double-masked and randomized study using specular microphotography.
abstract: Specular microscopy was used for investigation of cellular reactions on the intraocular lens (IOL) anterior surface of Heparin surface-modified (HSM) versus regular polymethylmethacrylate (PMMA) lenses (Pharmacia types 700C versus 700B, respectively). The double-masked randomized study included 53 patients investigated at 1 and 4 weeks postoperatively. Giant cells were only found on control lenses and more frequently at 4 weeks. Small cells were found on both lens types, but in a higher frequency on the control lenses. The number of small cells decreased during the first 4 weeks on both the control and HSM lenses. However, those control lenses that had giant cells on their surface showed an increase in the number of small cells during the same time. The results of the current study show that HSM lenses give rise to less postoperative inflammatory cellular reactions than regular PMMA lenses.
authors.affiliation: Department of Ophthalmology, Karolinska Institutet, Huddinge Hospital, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ygge
authors.forename: M
authors.initials: M
authors.lastname: Wenzel
authors.forename: B
authors.initials: B
authors.lastname: Philipson
authors.forename: P
authors.initials: P
authors.lastname: Fagerholm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D002477:Cells; D004311:Double-Blind Method; D015726:Giant Cells / Q000166:cytology*; D006493:Heparin; D006801:Humans; D007910:Lenses, Intraocular; D008768:Methylmethacrylates; D008875:Middle Aged; D010784:Photomicrography
chemical_list: D008768:Methylmethacrylates; D006493:Heparin