Royal Free Hospital protocol for 24-hour intragastric acidity and plasma gastrin concentration.
The Royal Free Hospital protocol for simultaneous measurement of 24-hour intragastric acidity and plasma gastrin concentration is described in detail. The methods of analysing such data are discussed, with recommendations for a standard four-way analysis: median hourly 24-hour intragastric acidity or pH, or plasma gastrin concentration; integrated 24-hour intragastric acidity, or plasma gastrin concentration; analysis of integrated values according to meal-related intervals; and quantification of the percentage of time in a 24-hour period that intragastric pH is greater than 3.
Pounder
R E
RE
Academic Department of Medicine, Royal Free Hospital, School of Medicine, London, UK.
Lanzon-Miller
S
S
Smith
J T
JT
Gavey
C
C
Nwokolo
C U
CU
Prewett
E J
EJ
Sercombe
J
J
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002985:Clinical Protocols; D005502:Food; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007441:Intubation, Gastrointestinal; D008991:Monitoring, Physiologic / Q000379:methods*; D013396:Suction / Q000379:methods*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D005755:Gastrins