title: Gag precursors of HIV and SIV are cleaved into six proteins found in the mature virions.
abstract: During retroviral maturation gag precursors are proteolytically cleaved to mature gag proteins. The number of mature gag proteins and their order in the gag precursors of HIV-I3B, SIVMne (captive macaque isolate), and SIVCat (wild mangabey isolate) has been determined by N-terminal amino acid sequence analysis of mature gag proteins and alignment with predicted sequences of homologous gag precursors. For HIV-1 and SIVs maturation proteolysis results in six gag proteins and the gag precursor cleavage pattern is distinctive and different from cleavage patterns for all other known retroviruses.
authors.affiliation: Program Resources, Inc., Frederick, MD.
authors.forename: L E
authors.initials: LE
authors.lastname: Henderson
authors.forename: R C
authors.initials: RC
authors.lastname: Sowder
authors.forename: T D
authors.initials: TD
authors.lastname: Copeland
authors.forename: S
authors.initials: S
authors.lastname: Oroszlan
authors.forename: R E
authors.initials: RE
authors.lastname: Benveniste
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002520:Cercopithecidae; D015683:Gene Products, gag / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012689:Sequence Homology, Nucleic Acid; D015302:Simian Immunodeficiency Virus / Q000378:metabolism*; D014771:Virion / Q000378:metabolism
chemical_list: D015683:Gene Products, gag; D011498:Protein Precursors