title: Isolation and characterization of infiltrates in the nerves of patients with neuritic leprosy.
abstract: A study was done on the characteristics of infiltrating cells in the nerves of 9 patients with pure neuritic leprosy, by preparing a single cell suspension. The patients had no skin lesion. Histopathological examination revealed that 2 of the 9 nerves showed granulomas characteristics of tuberculoid leprosy, while the remaining 7 had features of lepromatous granulomas. In the nerves showing tuberculoid granulomas, a high proportion of lymphocytes were T cells as they formed rosettes with sheep erythrocytes and only a few percent were EAC rosette forming cells. On the other hand, the nerves showing lepromatous granulomas contained only occasional lymphocytes which formed E and EAC rosettes. Macrophages from the granulomas of all the nerves were esterase positive, peroxidase negative, contained M. leprae and did not exhibit C3 surface receptors.
authors.affiliation: Central Jalma Institute for Leprosy, Agra, India.
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: R B
authors.initials: RB
authors.lastname: Narayanan
authors.forename: B K
authors.initials: BK
authors.lastname: Girdhar
authors.forename: G N
authors.initials: GN
authors.lastname: Malaviya
mesh_terms: D002478:Cells, Cultured; D005542:Forearm / Q000294:innervation; D006099:Granuloma / Q000473:pathology; D006801:Humans; D015440:Leprosy, Lepromatous / Q000473:pathology; D015441:Leprosy, Tuberculoid / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D010543:Peroneal Nerve / Q000473:pathology; D011826:Radial Nerve / Q000473:pathology; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology; D014459:Ulnar Nerve / Q000473:pathology