title: Nonsteroidal antiinflammatory agents. Part 20(3): Optically active thienyl-biphenylyl-hydroxypropionic acids.
abstract: The optically active diastereometric erythro- and threo-3-thienyl-analogues 6a-d of 3-aryl-2-biphenylyl-3-hydroxy-propionic acids have been prepared. Some stereoisomers of 3-(3-thienyl)derivative 6b showed inhibition around 40% in the carrageenan-induced rat paw edema test.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italia.
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: S
authors.initials: S
authors.lastname: Burnelli
authors.forename: A
authors.initials: A
authors.lastname: Guarnieri
authors.forename: G
authors.initials: G
authors.lastname: Scapini
authors.forename: V
authors.initials: V
authors.lastname: Andrisano
authors.forename: M
authors.initials: M
authors.lastname: Fantuz
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D007773:Lactates / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007773:Lactates; D013876:Thiophenes; D002351:Carrageenan