title: Lipid activators of protein kinase C.
abstract: Among the many reported lipid activators of protein kinase C only those of high affinity can be considered true physiological effectors, at present the tumor promoters, e.g., phorbol esters; 1,2-diacyl-sn-glycerols; and phosphatidylinositol 4,5-bisphosphate. Many other compounds (including arachidonic acid) are activators at high, unphysiological concentrations only, and they seem to be sterically unsuited for bonding to the enzyme. Such pseudo-activators possibly act by scrambling the structure of the regulatory moiety of the kinase.
authors.affiliation: New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
authors.forename: V P
authors.initials: VP
authors.lastname: Chauhan
authors.forename: A
authors.initials: A
authors.lastname: Chauhan
authors.forename: D S
authors.initials: DS
authors.lastname: Deshmukh
authors.forename: H
authors.initials: H
authors.lastname: Brockerhoff
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D008055:Lipids / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D008055:Lipids; D011493:Protein Kinase C