[Diagnostic changes in serum creatine kinase MM isoenzyme sub-bands after the onset of acute myocardial infarction].
The authors quantified the change of CK-MM isoforms in the first available serum sample from 16 patients each with acute myocardial infarction (AMI) and angina pectoris and 16 normal individuals as well. The average MM3/MM1 ratio in the normal group was 0.24 +/- 0.12, in angina group 0.21 +/- 0.13, and in AMI group 0.52 +/- 0.30 (P less than 0.001, as compare with the first two groups). The first blood sample of AMI was obtained in 3.0 +/- 1.9 hours after the onset of chest pain. Half of them (8/16) had a ratio of MM3/MM1 greater than 0.50 and the change occurred as early as 30 min after the attack. In contrast, the total CK and CK-MB in the three groups were within normal limits at the same time, they were 85.8 +/- 24.4 U/L for CK and 3.2 +/- 1.1% for CK-MB in patients with AMI, 66.7 +/- 18.0 U/L, 2.7 +/- 1.6% in angina pectoris and 71.4 +/- 24.5 U/L, 3.0 +/- 1.1% in normal subjects respectively. Accordingly, diagnostic change of CK-MM isoforms was the earliest among the enzymes after the onset of AMI.
Yang
X S
XS
Department of Cardiology, Chinese PLA General Hospital, Beijing.
Meng
Q Y
QY
Gong
W R
WR
D000368:Aged; D000369:Aged, 80 and over; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D013997:Time Factors
D007527:Isoenzymes; D003402:Creatine Kinase