Patterns of contact phase proteins indicating neuropathy in diabetic patients.
In 42 outpatients of the diabetology division, coagulation and fibrinolysis variables were determined in order to detect typical patterns of results with which it was possible to discriminate between three groups with different diabetic complications (17: no complication, 7: angiopathy alone, 18: neuropathy with or without other complications). There was a statistically significant discriminatory function involving C1-inhibitor concentration, high molecular weight kininogen coagulant activity and fibrinogen as the most decisive variables. The neuropathy group was appropriately separated from the others with an 81% correct reclassification. Heparin cofactor II, histidine-rich glycoprotein, alpha 2-macroglobulin, pre-kallikrein and factor XII had no discriminative power.
Meier
P
P
Coagulation and Fibrinolysis Laboratory, Kantonsspital, Basel, Switzerland.
Marbet
G A
GA
Berger
W
W
Duckert
F
F
Friedli
W
W
D000328:Adult; D000368:Aged; D003929:Diabetic Neuropathies / Q000097:blood*; D005260:Female; D015844:Heparin Cofactor II / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D000099053:Histidine-Rich Glycoprotein
D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; D015844:Heparin Cofactor II; D010958:Plasminogen