Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate.
A new methotrexate analog, 10-ethyl-10-deaza-aminopterin (10-EdAM), was found to induce a particular form of skin toxicity different than the skin rash reported to result from methotrexate. At histologic examination, it was found to be a toxic dermatitis that clinically most often first appears on the lower legs but can occur anywhere in the body, especially if treatment is continued. Nine cases are reported. A specific risk factor could not yet be identified. Discontinuation of 10-EdAM administration leads to complete healing; concomitant corticosteroid treatment also induces healing.
Verweij
J
J
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
Schornagel
J
J
de Mulder
P
P
Henzen-Logmans
S
S
Cognetti
F
F
Clavel
M
M
Vermorken
J
J
D000368:Aged; D000630:Aminopterin / Q000031:analogs & derivatives* / Q000633:toxicity; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D004341:Drug Evaluation; D005260:Female; D005493:Folic Acid Antagonists / Q000633:toxicity*; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects*
D005493:Folic Acid Antagonists; C040210:edatrexate; D000630:Aminopterin