title: [A clinical evaluation of the CA 72-4 serum level as a possible tumor marker].
abstract: The level of CA 72-4 in serum has been measured in various diseases by an immunoradiometric assay using CA 72-4 RIA Kit for an evaluation of its clinical significance as a possible tumor marker. CA 72-4 showed a high positive rate in patients with ovarian and bile duct cancers. In contrast, the false positive rate was low in benign gynecological and digestive diseases. Serum CA 72-4 was found to be increased in patients with a mucinous cystadenocarcinoma and in other histological types in the early stages of an ovarian cancer. Further, the serum CA 72-4 level changed in parallel with the clinical course of the ovarian cancer. Therefore, our results suggest that measurement of CA 72-4 be combined with measurement of CA 125, so as to provide a better sensitivity and specificity in monitoring an ovarian cancer.
authors.affiliation: Radioassay Center, Tokyo Women's Med. College.
authors.forename: K
authors.initials: K
authors.lastname: Jibiki
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: E
authors.initials: E
authors.lastname: Odagiri
authors.forename: R
authors.initials: R
authors.lastname: Demura
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: K
authors.initials: K
authors.lastname: Takizawa
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D013274:Stomach Neoplasms / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor