[Antigenicity test of mofezolac (N-22)].
Antigenicity studies of mofezolac (N-22) were examined in mice and guinea pigs and the following results were obtained. The findings of active systemic anaphylaxis, passive hemagglutination test, 4 hour passive cutaneous anaphylaxis (4-hr PCA) and 8-day PCA in guinea pigs revealed that N-22 possessed neither immunogenic nor eliciting potentiality. However, N-22 was shown to be eliciting antigenicity in mice when given N-22-ovalbumin conjugate plus Freund's complete adjuvant (FCA) as immunogen.
Takemoto
M
M
Daiichi Pure Chemicals Co., Ltd., Tokai Research Laboratories, Ibaraki, Japan.
Matsuo
K
K
Katoh
S
S
Yoshida
R
R
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D005260:Female; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007555:Isoxazoles / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000941:Antigens; D007555:Isoxazoles; D010047:Ovalbumin; D005620:Freund's Adjuvant; C054999:mofezolac