Contribution of pharmacokinetic computerized simulations in toxicological approach of ochratoxin A.
An open two-compartment model described the fate of ochratoxin A in the rat. Curves of toxin quantities contained in the two compartments and predicted plasma concentrations following 1-, 2-, or 3-daily administrations were simulated by use of mathematical expressions programmed for a digital computer. These studies clearly showed residues of ochratoxin A in deep compartment tissues such as muscle, fat, and skin. The pharmacokinetic profiles of ochratoxin A in pigs and broilers were also investigated and discussed.
Galtier
P
P
I.N.R.A. Laboratoire de Pharmacologie-Toxicologie, Toulouse, France.
Charpenteau
J L
JL
Alvinerie
M
M
D000818:Animals; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D009793:Ochratoxins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats
D009793:Ochratoxins; C025589:ochratoxin A