Estimation of the amount of alcohol ingested from a single blood alcohol concentration.
Capillary blood alcohol concentrations (BAL) measured in 22 young adult male volunteers each of whom received three different treatments of alcohol (total N = 66) have been related quantitatively to the dose of alcohol ingested. Linear regression with reasonably homogeneous variances have been found when the BAL at 2, 2.5 and 3 hr are divided by the person's body weight and plotted versus the g/kg (D/W) dose. Error analysis indicated that the least error in the predicted dose (D/W) was obtained for BAL measured at 2 hr post dosing. In the latter case the mean absolute error was 6.23%, 59% of the errors were within +/- 5% and 88% of the errors were within +/- 10%.
Wagner
J G
JG
College of Pharmacy, University of Michigan, Ann Arbor 48109.
Wilkinson
P K
PK
Ganes
D A
DA
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D000435:Alcoholic Intoxication / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005215:Fasting / Q000097:blood; D006801:Humans; D008297:Male; D012044:Regression Analysis; D013997:Time Factors
D000431:Ethanol