[Superoxide dismutases: significances in aging, diabetes, ischemia and cancer].
Superoxide dismutases (SOD) and their changes in diabetes, aging, ischemia and cancer were studied, Cu, Zn-SOD undergoes glycation reaction in vitro and in vivo and loses its activity by formation of Amadori compounds. Two lysine residues of Cu, Zn-SOD, Lys-122 and Lys-128 are primary glycated sites which are located on the surface of the molecule. The sites are also located on the active site liganding loop which plays a major role in the activity. The glycated Cu, Zn-SOD increased in the red cells of diabetic patients, especially those with diabetic complications. Mn-SOD appears in the serum of patients with acute myocardial infarction in a biphasic manner. The enzyme appears in sera 16 hr and 108 hr after the attack as determined by ELISA. The Mn-SOD levels are also increased in the serum of patients with epithelial ovarian cancer and it is a good marker for detecting and monitoring this cancer. Mn-SOD may play an important role in the ischemic and cancer tissues.
Taniguchi
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Department of Biochemistry, Osaka University Medical School.
D000375:Aging / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000201:enzymology*; D005260:Female; D006031:Glycosylation; D006801:Humans; D007511:Ischemia / Q000201:enzymology*; D008297:Male; D010051:Ovarian Neoplasms / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase