title: Rheoencephalographic and electroencephalographic studies on nicergoline.
abstract: The effect of nicergoline on the rheoencephalogram (REG) and on spontaneous electroencephalographic activity (EEG) was studied in acute experiments in cats. The following REG parameters were assayed: amplitude, anacrotic section of the curve and its relative part and dicrotic index. EEG spectra were derived from 10-sec samples of ECoG and the relative amplitude was estimated at 2 Hz-intervals from 0-44 Hz. The REG study showed that nicergoline (0.05 mg/kg i.v.) caused an increase of the amplitude, and a decrease of the anacrote, of the relative part of the anacrote and the dicrotic index - changes indicating a lowering of cerebrovascular resistance. EEG study showed a decrease of the slow activities (theta and delta), and an increase of the fast activities (alpha and beta-1).
authors.affiliation: Chemical Pharmaceutical Research Institute, Medical Academy, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Dikova
authors.forename: R
authors.initials: R
authors.lastname: Tsikalova
authors.forename: R
authors.initials: R
authors.lastname: Nikolov
authors.forename: M
authors.initials: M
authors.lastname: Nikolova
authors.forename: A
authors.initials: A
authors.lastname: Patroneva
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D008297:Male; D009530:Nicergoline / Q000494:pharmacology*; D012212:Rheology / Q000379:methods; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009530:Nicergoline