[18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies].
The authors review some current ideas concerning the role of 18-hydroxylated corticosteroids as mineralocorticoids themselves and as possible precursors of the principal mineralocorticoid, aldosterone. In particular, the physiological and pharmacological agents affecting their secretion are discussed together with a description of the methods used for their analysis in plasma in the department of Clinical Biochemistry Pitié-Salpétrière. Finally, the value of these assays in the differential diagnosis of mineralocorticoid hypertension and inborn errors of corticosteroid biosynthesis is assessed and the constraints on sampling technique listed.
Aupetit
B
B
Service Pr J.C. Legrand, CHU Pitié-Salpétrière, Paris.
Fraser
R
R
Vecsei
P
P
Zenatti
M
M
Lewicka
S
S
Corvol
P
P
Zaugg
N
N
Legrand
J C
JC
D015069:18-Hydroxycorticosterone / Q000097:blood* / Q000378:metabolism; D015070:18-Hydroxydesoxycorticosterone / Q000097:blood* / Q000378:metabolism; D000307:Adrenal Gland Diseases / Q000097:blood*; D000450:Aldosterone / Q000378:metabolism; D003900:Desoxycorticosterone / Q000378:metabolism; D006801:Humans
D015070:18-Hydroxydesoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone
18-Hydroxycorticostérone, 18-hydroxydésoxycorticostérone. Pourquoi, quand, comment en déterminer les taux plasmatiques dans certaines pathologies surrénaliennes.