[The similarity of the pathogenetic mechanisms of alcoholism and drug dependence and the means of searching for agents for treating these diseases].
The concept of the principal unity of the pivotal mechanisms underlying the formation of the syndrome of dependence on alcohol and various narcotic agents is presented. The central link of the mechanisms is the totality of the specific disturbances of neurochemical processes among which of particular importance are the specific changes in the functional state of catecholamine system. The theoretical approaches to the development of medicinal agents for treating alcoholism and drug addictions are considered. As an example there are discussed the results of using small doses of dopamine receptor stimulants (apomorphine and bromocriptine) and a neuropeptide cholecystokinin.
Anokhina
I P
IP
Kogan
B M
BM
Man'kovskaia
I V
IV
Reshchikova
E V
EV
Stanishevskaia
A V
AV
D000437:Alcoholism / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D000654:Amobarbital; D000818:Animals; D001058:Apomorphine / Q000627:therapeutic use; D001923:Brain Chemistry / Q000187:drug effects; D001971:Bromocriptine / Q000627:therapeutic use; D002395:Catecholamines / Q000378:metabolism; D002766:Cholecystokinin / Q000627:therapeutic use; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D009021:Morphine Dependence / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D001971:Bromocriptine; D002766:Cholecystokinin; D000654:Amobarbital; D001058:Apomorphine
Obshchnost' patogeneticheskikh mekhanizmov alkogolizma i narkomaniĭ i puti poiska sredstv dlia lecheniia étikh zabolevaniĭ.