title: Halothane reductive metabolism in an adult surgical population.
abstract: The reductive metabolism of halothane was studied in 34 adult patients undergoing routine surgery. Reductive biotransformation of halothane was more extensive in females than males and was also enhanced in two patients treated preoperatively with phenytoin, an enzyme-inducing drug. Tobacco, ethanol and the patient's age, body weight and previous exposure to halothane did not influence reductive metabolism of halothane.
authors.affiliation: Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Adelaide, South Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: Jenner
authors.forename: J L
authors.initials: JL
authors.lastname: Plummer
authors.forename: M J
authors.initials: MJ
authors.lastname: Cousins
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D001711:Biotransformation; D001944:Breath Tests; D005260:Female; D005459:Fluorides / Q000652:urine; D006221:Halothane / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000378:metabolism
chemical_list: D010672:Phenytoin; C016800:1,1,1-trifluoro-2-chloroethane; D005459:Fluorides; D006221:Halothane