title: Liver function tests in non-parenteral cocaine users.
abstract: To investigate the effect of cocaine on standard liver function tests (LFT), we studied 46 cocaine users with no history of parenteral drug use or homosexuality. LFT were similar in 21 users of cocaine only (Group A) and 25 users of cocaine and alcohol (Group B). Only three patients, two of whom were hepatitis B carriers, had an alanine aminotransferase level more than five units above normal limits. Group B patients were significantly more likely to complain of headaches, irritability, and loss of memory. We conclude that (1) non-parenteral cocaine use is rarely associated with significant LFT abnormalities and (2) alcohol may potentiate some adverse effects of cocaine.
authors.affiliation: Department of Medicine, Beth Israel Medical Center, New York, NY 10003.
authors.forename: J
authors.initials: J
authors.lastname: Tabasco-Minguillan
authors.forename: D M
authors.initials: DM
authors.lastname: Novick
authors.forename: M J
authors.initials: MJ
authors.lastname: Kreek
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D003042:Cocaine / Q000009:adverse effects*; D006509:Hepatitis B / Q000201:enzymology; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000201:enzymology; D008111:Liver Function Tests; D019966:Substance-Related Disorders / Q000201:enzymology*
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003042:Cocaine