title: Bretylium tosylate versus lidocaine in experimental cardiac arrest.
abstract: Bretylium tosylate has been shown effective in the treatment of ventricular fibrillation and in the prevention of its recurrence. However, lidocaine is generally preferred because bretylium could have adverse hemodynamic effects related to its antiadrenergic action. To explore further the differences between these two antiarrhythmic agents, the authors compared the effects of bretylium, lidocaine, and saline on a standardized dog model of ventricular fibrillation followed by electromechanical dissociation (EMD). The protocol included three successive episodes of cardiac arrest in each animal. Three minutes before each episode of ventricular fibrillation, 5 mg/kg of bretylium tosylate (n = 11), 1 mg/kg of lidocaine (n = 9) or saline (n = 12) were administered blindly. There was no difference in the duration of cardiac arrest (bretylium, 8 min 18 sec; lidocaine, 7 min 54 sec; saline, 8 min 20 sec) or the total doses of epinephrine required to resuscitate the animals. Both bretylium and lidocaine appeared to preserve cardiac function 5 minutes after recovery, as stroke volume increased from 17.8 +/- 6.7 to 18.7 +/- 6.7 mL (NS) after bretylium and from 17.7 +/- 7.7 to 19.0 +/- 7.0 mL (NS) after lidocaine, but decreased from 19.0 +/- 5.3 to 14.6 +/- 6.0 mL (P less than .05) after saline. During the first 10 minutes of EMD, ventricular fibrillation or ventricular tachycardia recurred in 4 dogs treated with lidocaine, 3 dogs treated with saline, but no dog treated with bretylium (P less than .05 between bretylium and saline).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
authors.forename: J L
authors.initials: JL
authors.lastname: Vachiery
authors.forename: C
authors.initials: C
authors.lastname: Reuse
authors.forename: S
authors.initials: S
authors.lastname: Blecic
authors.forename: B
authors.initials: B
authors.lastname: Contempré
authors.forename: J L
authors.initials: JL
authors.lastname: Vincent
mesh_terms: D000818:Animals; D001950:Bretylium Tosylate / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004554:Electric Countershock; D006323:Heart Arrest / Q000139:chemically induced / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D008012:Lidocaine / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000494:pharmacology; D013318:Stroke Volume / Q000187:drug effects; D014693:Ventricular Fibrillation / Q000188:drug therapy
chemical_list: D012965:Sodium Chloride; D001950:Bretylium Tosylate; D008012:Lidocaine