title: Methylphenidate in aggressive-hyperactive boys: I. Effects on peer aggression in public school settings.
abstract: One of the least documented "known" effects of methylphenidate in hyperactive children is the suppression of peer aggression. In this study, 11 aggressive-hyperactive children received a low (0.3 mg/kg) and moderate (0.6 mg/kg) dose of methylphenidate and placebo for 2 weeks each under double-blind conditions. Children were observed in public school settings during classroom seatwork activities, lunch, and recess. Results showed that methylphenidate suppressed nonphysical aggression (p = 0.06) in the classroom, and a moderate dose decreased physical aggression (p less than 0.01) and verbal aggression (p = 0.07) on the playground. The effect on the rate of appropriate social interaction was variable. The majority of subjects exhibited either the same or higher levels of appropriate social interaction on the 0.6 mg/kg dose compared with placebo. In the classroom, both doses of methylphenidate also resulted in reduced levels of motor movement, off-task behavior, noncompliance, and disruptiveness. Teacher ratings of hyperactivity and conduct problem symptoms revealed drug effects, whereas parallel parent instruments did not.
authors.affiliation: Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook, NY 11794-8790.
authors.forename: K D
authors.initials: KD
authors.lastname: Gadow
authors.forename: E E
authors.initials: EE
authors.lastname: Nolan
authors.forename: J
authors.initials: J
authors.lastname: Sverd
authors.forename: J
authors.initials: J
authors.lastname: Sprafkin
authors.forename: L
authors.initials: L
authors.lastname: Paolicelli
mesh_terms: D000374:Aggression / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage*; D010379:Peer Group; D012931:Social Environment
chemical_list: D008774:Methylphenidate