title: [Comparison of plasmatic and renal clearance of lithium].
abstract: The authors elaborated a method for assessment of the renal lithium clearance, CLr, the results of which correlate well with the plasmatic clearance (CLp] (r = 0.785, p less than 0.05). This correlation improved substantially after correction of CLr to the clearance of endogenous creatinine, CLcr (r = 0.945; p less than 0.05). The mean values of CLr of the investigated group--26.4 ml/min are in agreement with the results published by other authors. A significant correlation between CLr and CLcr (r = 0.826, p less than 0.05) along with comparison of the intraindividual variability of assessed results indicates that it is better to use as a parameter of sodium absorption from the proximal tubule the fractional lithium clearance rather than absolute values of CLr.
authors.affiliation: I. interní katedra 1. lékarské fakulty, Univerzity Karlovy, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Pospísil
authors.forename: M
authors.initials: M
authors.lastname: Merta
authors.forename: J
authors.initials: J
authors.lastname: Koubek
mesh_terms: D000328:Adult; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D008094:Lithium
vernacular_title: Srovnání plazmatické a renálni clearance lithia.