Studies on organ weights in naproxen treated rats after intermittent exposure to simulated high altitude.
Rats were exposed intermittently for 8 h per day over 6 days at simulated high altitude of 20,000 feet. One group of altitude-exposed animals was treated with naproxen, a prostaglandin inhibiting drug. Significant reduction in body weight gain was observed in both altitude-exposed and drug-treated altitude-exposed animals compared to the control group. Right and left ventricular weights and weights of the adrenal glands were increased significantly in altitude-exposed and altitude-exposed drug-treated animals. The weight of the spleen was increased significantly in altitude-exposed animals whereas no such increase of splenic weight was observed in drug-treated altitude-exposed group of animals. On the other hand, the weight of the liver was decreased significantly in both cases. In drug-treated altitude-exposed animals, the unaltered splenic weight was thought to be due to inhibition of the erythropoietic activity.
Saha
R C
RC
Department of Physiology, University College of Science and Technology, Calcutta, India.
Biswas
H M
HM
D000064:Acclimatization; D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000531:Altitude; D000818:Animals; D000860:Hypoxia / Q000473:pathology; D008297:Male; D009288:Naproxen / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects*; D051381:Rats; D013154:Spleen / Q000033:anatomy & histology / Q000187:drug effects
D009288:Naproxen