title: Studies on the effect of ascorbic acid and selenium on the genotoxicity of nitrofurans: nitrofurazone and furazolidone.
abstract: The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest.
authors.affiliation: Department of Biochemistry, Institute of Biopharmacy, Medical School, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Gajewska
authors.forename: M
authors.initials: M
authors.lastname: Szczypka
authors.forename: B
authors.initials: B
authors.lastname: Tudek
authors.forename: T
authors.initials: T
authors.lastname: Szymczyk
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics; D005664:Furazolidone / Q000037:antagonists & inhibitors* / Q000633:toxicity; D016296:Mutagenesis / Q000187:drug effects; D009153:Mutagens / Q000037:antagonists & inhibitors*; D009583:Nitrofurazone / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013014:SOS Response, Genetics / Q000187:drug effects; D012486:Salmonella typhimurium / Q000235:genetics; D012643:Selenium / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D009153:Mutagens; D005664:Furazolidone; D012643:Selenium; D001205:Ascorbic Acid; D009583:Nitrofurazone