title: Evidence against linkage of the gene for Usher's syndrome type 1 with group specific component (GC) on chromosome 4.
abstract: A linkage of the gene for Usher's syndrome with group specific component (GC) on the long arm of chromosome 4 has been suggested by Pelias et al., in 1988. A panel of 38 individuals from 7 kindreds with Usher's syndrome type 1 has been established to test this hypothesis. A negative lodscore was found and close linkage was excluded.
authors.affiliation: Service de Pédiatrie, Centre Hospitalier Régional Universitaire de Poitiers, France.
authors.forename: D
authors.initials: D
authors.lastname: Bonneau
authors.forename: J
authors.initials: J
authors.lastname: Kaplan
authors.forename: M
authors.initials: M
authors.lastname: Berthier
authors.forename: J
authors.initials: J
authors.lastname: Séger
authors.forename: J L
authors.initials: JL
authors.lastname: Dufier
authors.forename: J
authors.initials: J
authors.lastname: Frézal
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D002648:Child; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005808:Genes, Recessive; D006312:Hearing Loss, Bilateral / Q000235:genetics*; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D012174:Retinitis Pigmentosa / Q000235:genetics*; D013577:Syndrome; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D014809:Vitamin D-Binding Protein