Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage.
A considerable quantity of endothelin-like immunoreactivity was demonstrated as present in the CSF of patients with subarachnoid hemorrhage. The endothelin levels in the CSF raised from 0.4 +/- 0.2 (Mean +/- SD) pmol/L at Day 0-1 to 2.2 +/- 0.6 pmol/L at Day 6 and the levels decreased gradually. The result suggest that endothelin may contribute the generation of vasospasm often observed in subarachnoid hemorrhage.
Suzuki
H
H
Department of Endocrinology, Dokkyo University School of Medicine, Mibu, Japan.
Sato
S
S
Suzuki
Y
Y
Takekoshi
K
K
Ishihara
N
N
Shimoda
S
S
D016232:Endothelins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid*
D016232:Endothelins