In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) against Aspergillus and Candida species.
The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen against Candida albicans and Candida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates of Candida parapsilosis or three Aspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
Huang
A
A
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
Edwards
F
F
Bernard
E M
EM
Armstrong
D
D
Schmitt
H J
HJ
D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D054714:Echinocandins; D010455:Peptides / Q000494:pharmacology; D010456:Peptides, Cyclic
D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; C042101:cilofungin