Geriatric pharmacokinetics and the kidney.
The general population is aging and, as a result, drugs are increasingly prescribed for a variety of medical conditions in a group of patients with multiple physiologic and pharmacokinetic abnormalities. The present report summarizes principles of prescribing for the elderly, especially those related to the decline in renal function that frequently occurs.
Bennett
W M
WM
Department of Medicine, Oregon Health Sciences University, Portland 97201.
D000042:Absorption; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D011307:Drug Prescriptions; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology