title: [Correction of protease-protease inhibitor imbalance by intrapulmonary administration of contrical in the treatment of patients with chronic nonspecific lung diseases].
abstract: The ratio of proteinases and their inhibitors in bronchoalveolar washings was studied in 38 patients with chronic nonspecific diseases of the lungs. A decrease in the inhibitor potential was detected. Contrical, an inhibitor of proteolytic enzymes, was used in the treatment of the patients. A new procedure for trans-thoracic++ intrapulmonary administration of contrical with an ISI-1 needle jet injector was shown to be efficient. It provided delivery of the drug in optimal daily doses immediately into the inflammation focus.
authors.forename: V M
authors.initials: VM
authors.lastname: Provotorov
authors.forename: G G
authors.initials: GG
authors.lastname: Semenkova
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007277:Injections, Jet; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008171:Lung Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011480:Protease Inhibitors / Q000008:administration & dosage*
chemical_list: D011480:Protease Inhibitors; D010196:Pancreatic Elastase
vernacular_title: Korrektsiia disbalansa proteinazy-ingibitory vnutrilegochnym vvedeniem kontrikala pri lechenii bol'nykh khronicheskimi nespetsi- ficheskimi zabolevaniiami legkikh.