Sodium-activated potassium current in mouse diaphragm.
The mouse diaphragm muscle fiber was studied using the loose patch clamp technique. The voltage gated sodium currents were evoked by step pulses from a holding potential of about - 70 mV. Following the activation of the sodium current, a very large and fast outward current was evoked. The sensitivity of this current to 4-aminopyridine and tetraethylammonium indicates the potassium ion as the possible carrier for the channel. Furthermore, the sensitivity to tetrodotoxin and extracellular sodium demonstrated the sodium dependence of this current.
Re
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Department of Pharmacology--I.M.O., University Medical School, Ancona, Italy.
Moretti
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V
Rossini
L
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Giusti
P
P
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003964:Diaphragm / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels; D011188:Potassium