title: Long-term effects of intense sound on hair cells of Corti's organ and endocochlear DC potential.
abstract: Cochleograms of guinea pig ears were made 30-40 days after exposure to intense pure tones of 300 Hz, 500 Hz, 2 kHz, or 4 kHz at 130-150 dB SPL for 4-24 h. At 4 kHz, hair cells in the basal turn disappeared totally, in the second turn moderately, and were relatively undamaged in the third and apical turns. At 500 Hz, hair cells in the second and third turns were almost completely injured and at 300 Hz moderately damaged in the third and apical turns although the basal turn remained undamaged. At 2 kHz for 9 h, hair cells were almost completely injured in all turns. Negative endocochlear DC potential (negative EP) induced by furosemide was observed in the basal turn but not in the third turn of animals exposed to 300 Hz. Contrarily, negative EP was observed in the third turn but not in the basal turn of animals exposed to 4 kHz. We conclude that the hair cells of Corti's organ play an essential role in the production of negative EP.
authors.affiliation: Department of Otorhinolaryngology, Miyazaki Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ide
authors.forename: T
authors.initials: T
authors.lastname: Morimitsu
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000473:pathology / Q000502:physiology*; D009925:Organ of Corti / Q000473:pathology / Q000502:physiology*; D012022:Reflex, Acoustic / Q000502:physiology; D013018:Sound Spectrography; D013997:Time Factors