title: Parkinson's disease and cytochrome P450: a possible link?
abstract: The possibility that idiopathic Parkinson's disease may be linked to a deficiency of an important detoxifying enzyme such as the cytochrome P450 enzyme bufuralol hydroxylase is examined. A hypothetical model of how this might operate to produce early onset Parkinson's disease is suggested.
authors.affiliation: Department of Physiology, National University of Singapore.
authors.forename: G S
authors.initials: GS
authors.lastname: Shahi
authors.forename: N P
authors.initials: NP
authors.lastname: Das
authors.forename: S M
authors.initials: SM
authors.lastname: Moochhala
mesh_terms: D001921:Brain / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D020267:MPTP Poisoning; D006899:Mixed Function Oxygenases / Q000172:deficiency; D008954:Models, Biological; D010300:Parkinson Disease / Q000201:enzymology* / Q000209:etiology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced
chemical_list: D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C043872:bufuralol 1'-hydroxylase; D004298:Dopamine