Experimental studies on thallium toxicity in rats. II--The influence of several antidotal treatments on the tissue distribution and elimination of thallium, after subacute intoxication.
The influence of several antidotal treatments--e.g. Prussian Blue + Furosemide, Furosemide, activated Charcoal, Potassium Chloride and Potassium Iodide--on the tissue distribution and elimination of thallium after subacute intoxication is studied. From these experiments, the fate of electrolytes (Na+, K+, Cl-) may be evaluated. It was established that the efficacy of an antidotal treatment in thallium intoxication may be judged not only by the determination of its ability to interfere in the reabsorption and redistribution of thallium. Prussian Blue was the only antidotal that did not cause such a dangerous redistribution.
Leloux
M S
MS
Netherlands Institute for Drug and Doping Research, State University Utrecht, The Netherlands.
Nguyen
P L
PL
Claude
J R
JR
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013793:Thallium / Q000493:pharmacokinetics* / Q000633:toxicity; D014018:Tissue Distribution
D000931:Antidotes; D013793:Thallium