title: The natural history of Peyronie's disease.
abstract: The natural history of Peyronie's disease was evaluated in 97 men by means of a questionnaire. Disease duration ranged from 3 months to 8 years. Questions addressed pain, bending, ability for intercourse, over-all effect of the disease, psychological effects, treatments received and degree of disease progression. Approximately 40% of the patients found pain, bending, ability for intercourse and over-all effects to be unchanged during the course of the disease. Bending and ability for relations worsened in 40% of the patients during the same interval, while only 6% had worsening of pain. Of the patients 77% reported psychological effects due to Peyronie's disease, which improved in 28%, did not change in 36% and worsened in 36%. Over-all, 13% of the patients believed the disease to be one of gradual resolution, 47% believed there had been little or no change and 40% believed that the disease pattern was one of gradual progression. We found no statistically significant association between disease duration and spontaneous improvement in penile bending. A similar lack of statistical significance was found when improvement in a variety of categories was compared in patients who received no therapy versus those who received a variety of conventional medical therapies.
authors.affiliation: Division of Urology and Biostatistics, UCLA School of Medicine.
authors.forename: M K
authors.initials: MK
authors.lastname: Gelbard
authors.forename: F
authors.initials: F
authors.lastname: Dorey
authors.forename: K
authors.initials: K
authors.lastname: James
mesh_terms: D001294:Attitude to Health; D003075:Coitus / Q000502:physiology; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000502:physiology; D010411:Penile Induration / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D011795:Surveys and Questionnaires; D013997:Time Factors