Hyperlactatemia and increasing metabolic acidosis in hepatorenal failure treated by hemofiltration.
We report a case of increasing hyperlactatemia in the course of repeated treatment by machine hemofiltration (MHF) using a lactate-buffered replacement solution. The hyperlactatemia was associated with a reduction in mean arterial pressure, and in the majority of treatments a metabolic acidosis developed. Hyperlactatemia due to exogenous lactate may not be as benign as previously discussed.
Davenport
A
A
Department of Renal Medicine, St. Jame's University Hospital, Leeds, England.
Aulton
K
K
Payne
R B
RB
Will
E J
EJ
D000140:Acidosis, Lactic / Q000209:etiology*; D000368:Aged; D002021:Buffers; D015314:Dialysis Solutions; D005260:Female; D006440:Hemofiltration; D006530:Hepatorenal Syndrome / Q000628:therapy*; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid
D002021:Buffers; D015314:Dialysis Solutions; D007773:Lactates; D019344:Lactic Acid