[Acute meningitis without cutaneous manifestations caused by varicella zoster virus--intrathecal synthesis of specific antibodies].
The results of virusologic and cytobiochemical evaluation of CSF and serum samples of four patients with acute viral meningitis (AVM), most probably induced by varicella zoster virus (VZV), are reported. In no case VZV infection was not cutaneously manifested. Aetiologic diagnosis was established according to the presence of specific anti VZV AVM, in spite of their presence in the sera. On samples detected by indirect enzyme immunoassay (EIA). Four different antibody indexes were used to prove that the antibodies were intrathecally synthesized. Other viral antibodies (HSV, mumps) were not evident in the CSF samples of the patients with VZV avm, in spite of their presence in the sera. On the other hand, anti VZV antibodies could not be identified in the CSF samples of the controls (AVM of other aetiology, meningism) in spite of their presence in the sera. A possible aetiologic link between anti VZV antibodies presence in the CSF samples and some neurologic syndromes is discussed.
Nikolić
S
S
Vujosević
M
M
Zerajev
S
S
Dulović
O
O
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity; D006562:Herpes Zoster / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008587:Meningitis, Viral / Q000276:immunology* / Q000382:microbiology; D008875:Middle Aged; D012867:Skin / Q000473:pathology
D000914:Antibodies, Viral; D007136:Immunoglobulins
Akutni meningitis izazvan varicella zoster virusom bez kutanih manifestacija--intratekalna sinteza specificnih antitela.