Shared idiotype expression by chronic lymphocytic leukemia and B-cell lymphoma.
Antiidiotype (Id) antibodies identify unique determinants within the surface immunoglobulin (Ig) that are present on B-cell tumors. Anti-Ids have been used for diagnosis and therapy of B-cell lymphoma and leukemia. A panel of 29 anti-Id monoclonal antibodies (MoAbs) that recognize shared idiotypes (SIds) on B-cell lymphomas was tested for reactivity with both B-cell leukemias and lymphomas. Ten of 40 (25%) cases of chronic lymphocytic leukemia (CLL) reacted with at least one of the 29 anti-SId MoAbs. Three cases reacted with more than one anti-SId MoAb, but there was no repetitive pattern of a single anti-SId MoAb reacting with a large proportion of CLL cases. In contrast, for B-cell lymphoma, in which 11 of 31 (36%) cases reacted, one anti-SId (B4-1) reacted with five of the positive cases; all were diffuse histology. Restricted anti-SId reactivity may lead to important insights into the etiology of certain B-cell lymphomas. In addition, these anti-SIds may obviate the need to develop "tailor-made" antibodies for individual patients.
Chatterjee
M
M
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263.
Barcos
M
M
Han
T
T
Liu
X L
XL
Bernstein
Z
Z
Foon
K A
KA
D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D015870:Gene Expression; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D011947:Receptors, Antigen, B-Cell