Mechanism of the vasodilator action of pinacidil.
The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K+ permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K+ permeability. Lastly, the results suggest that the K+ channels involved are sensitive to glibenclamide.
Mulvany
M J
MJ
Danish Biomembrane Research Center, Aarhus University, Denmark.
Videbaek
L M
LM
Hughes
A D
AD
Aalkjaer
C
C
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology*; D008564:Membrane Potentials; D020110:Pinacidil; D015221:Potassium Channels / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D006146:Guanidines; D015221:Potassium Channels; D014665:Vasodilator Agents; D020110:Pinacidil