title: Behavioral effects of chronic imipramine treatment in genetically nervous pointer dogs.
abstract: The genetically nervous pointer dog has been proposed as a model for human anxiety disorders. In a double-blind placebo-controlled study, seventeen nervous pointer dogs were treated for four weeks with imipramine hydrochloride (10 mg/kg), a potent antipanic agent in humans. Although three of the dogs demonstrated marked improvement to imipramine but not placebo treatment after short-term administration, chronic imipramine failed to modify the aberrant behavior in any of the dogs. These findings are discussed in the context of the nervous pointer dog as a model for human anxiety disorders.
authors.affiliation: Section of Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892.
authors.forename: M E
authors.initials: ME
authors.lastname: Tancer
authors.forename: M B
authors.initials: MB
authors.lastname: Stein
authors.forename: B B
authors.initials: BB
authors.lastname: Bessette
authors.forename: T W
authors.initials: TW
authors.lastname: Uhde
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000235:genetics; D004285:Dogs / Q000235:genetics*; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D012931:Social Environment; D013045:Species Specificity
chemical_list: D007099:Imipramine