title: Generation of human endothelin by cathepsin E.
abstract: Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.
authors.affiliation: Department of Biochemistry, University of Wales College of Cardiff, UK.
authors.forename: W E
authors.initials: WE
authors.lastname: Lees
authors.forename: S
authors.initials: S
authors.lastname: Kalinka
authors.forename: J
authors.initials: J
authors.lastname: Meech
authors.forename: S J
authors.initials: SJ
authors.lastname: Capper
authors.forename: N D
authors.initials: ND
authors.lastname: Cook
authors.forename: J
authors.initials: J
authors.lastname: Kay
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002402:Cathepsin D / Q000378:metabolism; D020059:Cathepsin E; D002403:Cathepsins / Q000378:metabolism*; D016232:Endothelins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013379:Substrate Specificity
chemical_list: D016232:Endothelins; D002403:Cathepsins; D020059:Cathepsin E; D002402:Cathepsin D