title: [A comparative analysis of the effect of clofelin on gastric secretory function in man and dog].
abstract: It is established that clofelin suppresses the human and dog insulin gastric secretion as well as human basal and histamine secretion. Clofelin has no effect on the secretory function of the dog stomach, stimulated by pentagastrin, carbachol histamine. It is supposed that clofelin-induced suppression of the human histamine gastric secretion takes place due to the inhibition of basal secretory component being a part of the common secretory effect on histamine. Clofelin may be promising drug in the treatment of patients with hypertension and duodenum ulcer.
authors.forename: S D
authors.initials: SD
authors.lastname: Groĭsman
authors.forename: A A
authors.initials: AA
authors.lastname: Fisher
authors.forename: V I
authors.initials: VI
authors.lastname: Gel'vikh
authors.forename: S I
authors.initials: SI
authors.lastname: Shvydchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Shevchenko
authors.forename: S V
authors.initials: SV
authors.lastname: Kazakova
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004285:Dogs; D004347:Drug Interactions; D005215:Fasting / Q000502:physiology; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D013045:Species Specificity; D013997:Time Factors
chemical_list: D003000:Clonidine
vernacular_title: Sravnitel'nyĭ analiz éffekta klofelina na sekretornuiu funktsiiu zheludka u cheloveka i sobaki.