[Regulation mechanisms in prolactin secretion. Possible role of the hypophyseal renin-angiotensin system].
Recent studies have shown a possible role of different factors in the regulation of prolactin secretion. In fact many neurotransmitters (dopamine) and peptides can modulate prolactin release from anterior pituitary lactotrophs. In vitro and in vivo studies, Angiotensin II has been shown to increase prolactin release. On the basis of these data we have studied the effects of enalapril (ACE-Inhibitor) on baseline plasma prolactin in nine hypertensive post-menopausal women. The results indicate that 15-day inhibition of angiotensin-converting enzyme by enalapril significantly reduced serum prolactin levels. These data suggest that the Angiotensin II may play a role in the control of prolactin secretion in hypertensive women.
Lombardi
C
C
Divisione di Medicina Interna, Ospedale S. Orsola, Brescia, Italia.
Missale
C
C
Poli
M
M
De Cotiis
R
R
Memo
M
M
Spedini
C
C
Spano
P F
PF
D000368:Aged; D004311:Double-Blind Method; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008593:Menopause / Q000097:blood; D008875:Middle Aged; D010902:Pituitary Gland / Q000502:physiology; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
D004656:Enalapril; D011388:Prolactin
Meccanismi di regolazione della secrezione di prolattina. Possibile ruolo del sistema renina-angiotensina ipofisario.