Toxoplasmic chorioretinitis and hepatic granulomas.
A 71-yr-old male presented with a 2-month history of fever, malaise, and weight loss. Physical exam revealed chorioretinitis. Laboratory studies were notable for elevated levels of alkaline phosphatase, gamma-glutamyl transpeptidase, aspartate transaminase, and alanine transaminase. Immunoglobulin G antibody to Toxoplasma gondii was positive to a dilution of 1:4096, whereas serologic studies for hepatitis A virus, hepatitis B virus, cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus, Brucella, and Tularemia were negative. A percutaneous biopsy of the liver revealed hepatic granulomas. Culture of the biopsy specimen was negative for growth of mycobacteria or fungi. Spontaneous improvement in clinical and laboratory parameters occurred over a 4-month period.
Ortego
T J
TJ
Department of Gastroenterology, University of Arkansas for Medical Sciences, Little Rock.
Robey
B
B
Morrison
D
D
Chan
C
C
D000368:Aged; D002825:Chorioretinitis / Q000150:complications*; D006099:Granuloma / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D014126:Toxoplasmosis, Ocular / Q000150:complications*