Anti-inflammatory activity of some copper(II) complexes.
Anti-inflammatory activity of some copper(II) neutral complexes and complexated salts on different animal models of inflammation has been investigated. In a preliminary screening 5 complexes were selected for a more extensive study based on their capacity inhibiting the rat hind paw edema induced by carrageenin. These selected complexes showed inhibitory action on acute and subacute inflammation with an activity degree higher than that of indometacin. They were also effective inhibitors of primary and secondary lesions in the adjuvant-induced arthritis, with an activity similar to phenylbutazone. These complexes had no topical anti-inflammatory effect.
Frechilla
D
D
Departamento de Farmacología, Universidad de Navarra, Pamplona, Spain.
Lasheras
B
B
Ucelay
M
M
Parrondo
E
E
Craciunescu
G
G
Cenarruzabeitia
E
E
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000503:physiopathology; D002351:Carrageenan; D003300:Copper / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy / Q000503:physiopathology; D003368:Gossypium; D006099:Granuloma / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014221:Triamcinolone / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014221:Triamcinolone; D003300:Copper; D002351:Carrageenan; D010653:Phenylbutazone; D007213:Indomethacin