Fructosamine compared with a glucose load as a screening test for gestational diabetes.
Five hundred seven women were screened for gestational diabetes between 20-36 weeks' gestation. All received a 100-g glucose (polycose) load at 28 weeks with measurement of plasma glucose 1 hour later. Fructosamine levels were measured at 4-week intervals from 20-36 weeks. At 36 weeks, a full 100-g 3-hour glucose tolerance test was performed on all subjects. Eighteen women were diagnosed as having gestational diabetes. The glucose load had a sensitivity of 81% in detection of gestational diabetes, compared with 50% for fructosamine at 36 weeks. Fructosamine is not useful as a screening test for gestational diabetes as currently defined.
Roberts
A B
AB
Department of Obstetrics, National Women's Hospital, Auckland, New Zealand.
Baker
J R
JR
Metcalf
P
P
Mullard
C
C
D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000517:prevention & control; D005260:Female; D019270:Fructosamine; D005951:Glucose Tolerance Test; D006595:Hexosamines; D006801:Humans; D008403:Mass Screening; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000175:diagnosis* / Q000517:prevention & control; D012680:Sensitivity and Specificity
D006595:Hexosamines; D019270:Fructosamine