title: Metabolic reduction in hypothermia: pathophysiological problems and natural examples--Part 2.
abstract: As an example of spontaneous cooling in homeothermic organisms, hibernation of mammals is described. Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia. The observation that there is, in natural lethargic states, a certain independence between metabolic rate and body temperature, subsequently leads to considerations on the presumable modulating influence exerted by the acid-base balance. Finally, referring to the time limitations of such adaptation strategies, the cold-induced disintegration of metabolic processes with differing temperature dependence is illustrated which, however, will be more pronounced in the intermediate temperature range than in lower cooling. Thus, despite a limited cold tolerance, an extremely profound hypothermia of short duration seems not altogether impossible even for large homeotherms, provided some adequate conditions of rewarming are observed.
authors.affiliation: Department of Physiology and Pathophysiology, University of Göttingen, FRG.
authors.forename: D
authors.initials: D
authors.lastname: Singer
authors.forename: H J
authors.initials: HJ
authors.lastname: Bretschneider
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D001481:Basal Metabolism / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D003080:Cold Temperature; D004734:Energy Metabolism / Q000502:physiology; D006605:Hibernation / Q000502:physiology*; D006801:Humans; D007035:Hypothermia / Q000378:metabolism* / Q000503:physiopathology