Equal parental origin of chromosome 22 losses in human sporadic meningioma: no evidence for genomic imprinting.
Inactivation of tumor suppressor genes can occur either by mutation at the gene locus or by loss of part or all of the chromosome region containing the gene. The latter is most frequently detected by DNA markers as loss of heterozygosity in the tumor tissue. In several reports, the paternal homologue was preferentially retained in embryonal tumors associated with loss of particular chromosomal regions, suggesting genomic imprinting of the corresponding tumor suppressor loci. To explore the generality of these findings and the possible role of genomic imprinting in adult tumors of the nervous system, we have determined the parental origin of chromosome 22 loss in sporadic meningioma. Of nine cases studied, five tumors retained the maternally derived chromosome 22 homologue while four retained the paternally derived chromosome 22. Thus, in contrast to the embryonal tumors, the meningioma locus on chromosome 22 is inactivated by random mutation in sporadic adult meningiomas.
Fontaine
B
B
Molecular Neurogenetics Laboratory, Massachusetts General Hospital-East, Charlestown 02129.
Rouleau
G A
GA
Seizinger
B
B
Jewell
A F
AF
Hanson
M P
MP
Martuza
R L
RL
Gusella
J F
JF
D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D004247:DNA / Q000032:analysis*; D005260:Female; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D007962:Leukocytes / Q000737:chemistry; D008297:Male; D008579:Meningioma / Q000235:genetics*; D009154:Mutation; D010375:Pedigree
D005819:Genetic Markers; D004247:DNA