Complexes involving quercetin, DNA and Cu(II).
The genotoxic flavonoid, quercetin, was shown to bind to both double-stranded and single-stranded DNA with concomitant changes in absorption spectrum and fluorescence emission spectrum of quercetin. Quercetin and Cu(II) were shown to form a charge transfer complex that decayed in oxygen-dependent reaction(s) and this decay was accelerated by DNA. Analysis of the three component system, DNA--querectin--Cu(II), led to a discussion of the complexes likely to be involved in the initial reactions that lead, ultimately, to strand scission of DNA.
Rahman
A
A
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
Shahabuddin
Hadi
S M
SM
Parish
J H
JH
D003300:Copper / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism; D004347:Drug Interactions; D011794:Quercetin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D004277:DNA, Single-Stranded; D003300:Copper; D004247:DNA; D011794:Quercetin