title: Hyperkalemic periodic paralysis in horses.
abstract: Eleven horses (3 mares, 7 stallions, 1 gelding) with clinical and biochemical evidence of hyperkalemic periodic paralysis were studied. Each horse had history of episodic weakness, muscular tremors, or collapse, which lasted for periods of a few minutes to hours. Diagnosis was based on hyperkalemia in association with a spontaneous episode of paralysis or by precipitation of an episode by oral administration of potassium chloride. Clinical and biochemical events were documented during spontaneous and induced episodes of muscular weakness. During episodes, electrocardiographic findings were consistent with hyperkalemia. Electromyography performed between episodes revealed fibrillation potentials and positive sharp waves, complex repetitive discharges, and myotonic discharges. Histologic changes in muscle biopsy specimens varied from no overt changes in some horses to vacuolation in type-2B fibers with mild degenerative changes in other horses. Electron microscopy of myofibers revealed dilatations of the sarcoplasmic reticulum. Analysis of blood samples taken serially during induced attacks in 5 horses revealed marked hyperkalemia (5.5 to 9.0 mEq/L), with normal acid-base status, hemoconcentration, and modest changes in muscle-derived enzymes. Close correlation (r2 = 0.882) between total plasma protein and plasma potassium concentrations was observed and indicated a shift of fluid out of the extracellular fluid compartment. Treatment of either spontaneous or induced episodes by IV administration of calcium, glucose, or bicarbonate resulted in rapid recovery. Dietary management or daily administration of acetazolamide effectively controlled episodes. An affected mare was bred to an affected stallion, and 3 affected offspring were produced by embryo transfer. Blood samples from another extended family of affected horses were analyzed for identification of a genetic marker.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: S J
authors.initials: SJ
authors.lastname: Spier
authors.forename: G P
authors.initials: GP
authors.lastname: Carlson
authors.forename: T A
authors.initials: TA
authors.lastname: Holliday
authors.forename: G H
authors.initials: GH
authors.lastname: Cardinet
authors.forename: J G
authors.initials: JG
authors.lastname: Pickar
mesh_terms: D000818:Animals; D004562:Electrocardiography / Q000662:veterinary; D004576:Electromyography / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000235:genetics / Q000503:physiopathology*; D006736:Horses; D006947:Hyperkalemia / Q000150:complications / Q000235:genetics / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D010243:Paralysis / Q000150:complications / Q000235:genetics / Q000503:physiopathology / Q000662:veterinary*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013577:Syndrome
chemical_list: D012964:Sodium; D011188:Potassium