[Prolonged confusion syndrome in the course of cyclosporine treatment: a state of confusion?].
Cyclosporine is a potent immunosuppressant that is more and more widely used, particularly after organ transplantations. Many neurological side effects, including convulsions, that could be related to this drug, have been previously observed, most often with high blood concentrations. We report, for the first time, a case of prolonged confusion where a non convulsive status epilepticus may be discussed. It occurred in a 64-year-old woman, 17 days after a liver transplantation. The whole blood cyclosporine value was 230 micrograms/l (normal range: 100-200 micrograms/l) at the beginning of the status epilepticus. The cyclosporine imputability and the part of other factors that could have facilite are discussed.
Delpont
E
E
Laboratoire d'explorations fonctionnelles du système nerveux, hôpital Pasteur, Nice, France.
Thomas
P
P
Gugenheim
J
J
Chichmanian
R M
RM
Mahagne
M H
MH
Suisse
G
G
Dolisi
C
C
D002908:Chronic Disease; D003221:Confusion / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008875:Middle Aged; D011182:Postoperative Care; D013226:Status Epilepticus / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology
D003524:Cyclosporins
Syndrome confusionnel prolongé au cours d'un traitement par ciclosporine: état de mal à expression confusionnelle?