[The effect of alpha-ketoglutarate, malate and alpha-glycerophosphate on bioenergetic processes in ischemic myocardium].
Anti-ischemic action of exogenous natural metabolites and their effect on biological combustion processes indexes in cardiac muscle has been investigated on white rats with the experimental myocardial infarction. It has been established that the marked cardioprotective effect of malate and alpha-ketoglutarate is associated with the glycolysis and enzymes activation of creatine kinase system of energy transport. At the same time malate activates pentose-phosphate cycle and tissue respiration enzymes. alpha-glycerophosphate displays definite anti-ischemic properties not associated with the intervention into biological combustion processes.
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D000818:Animals; D003327:Coronary Disease / Q000378:metabolism* / Q000517:prevention & control; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005994:Glycerophosphates / Q000378:metabolism / Q000494:pharmacology*; D007656:Ketoglutaric Acids / Q000378:metabolism / Q000494:pharmacology*; D008293:Malates / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005994:Glycerophosphates; D007656:Ketoglutaric Acids; D008293:Malates; C030298:malic acid; C029620:alpha-glycerophosphoric acid
Vliianie alpha-ketoglutarata, malata i alpha-glitserofosfata na bioénergeticheskie protsessy v ishemizirovannom miokarde.