A prospective study on antiribosomal P proteins in two cases of familial lupus and recurrent psychosis.
In two siblings with systemic lupus erythematosus (SLE), who experienced two episodes of psychosis each, a longitudinal study of autoantibodies, including antibodies to ribosomal P proteins, is described. In two of three evaluable periods of 15 weeks antedating psychosis a rise followed by a spontaneous drop in anti-P levels was recorded. In the third period antibodies to ribosomal protein P were absent. It is concluded that results with single samples are not informative, and that frequent measurement of antibodies to ribosomal protein P in patients with SLE may have limited predictive value for psychosis.
Derksen
R H
RH
Division of Immunopathology, Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
van Dam
A P
AP
Gmelig Meyling
F H
FH
Bijlsma
J W
JW
Smeenk
R J
RJ
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology* / Q000523:psychology; D010750:Phosphoproteins / Q000276:immunology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015800:Protozoan Proteins; D011618:Psychotic Disorders / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D012008:Recurrence; D012269:Ribosomal Proteins / Q000276:immunology*
D001323:Autoantibodies; C064601:L12E protein, Trypanosoma cruzi; D010750:Phosphoproteins; D015800:Protozoan Proteins; D012269:Ribosomal Proteins