Hypoglycemic action of Salvia lavandulifolia Vahl. spp. oxyodon:a contribution to studies on the mechanism of action.
Having previously demonstrated the hypoglycemic action of Salvia lavandulifolia Vahl, subspecies oxyodon, the mechanism of action was further investigated. The hypoglycemic action may be the result of several synchronous mechanisms: a) potentiation of insulin release induced by glucose, b) increased peripheral uptake of glucose, c) decreased intestinal absorption of glucose and d) hyperplasia of the pancreatic islet beta cells (seen after chronic treatment).
Zarzuelo
A
A
Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Spain.
Risco
S
S
Gámez
M J
MJ
Jimenez
J
J
Cámara
M
M
Martinez
M A
MA
D000818:Animals; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D007515:Islets of Langerhans / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D013030:Spain
D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D005947:Glucose