[Initial experiences in diagnosis of graft rejection following clinical heart transplantation. Detection of graft-directed activated T-cells].
The binding of antigen-loaded carrier to mononuclear cells of heart transplant recipients has been investigated by means of an antigen-specific rosette technique. The increase of rosette forming cells and the inhibition of this reaction with monoclonal antibodies against activated T-cells is a sign of a beginning rejection. 3-6 days later infiltrating immunological competent cells are seen in biopsy.
Werner
M
M
Klinik für Chirurgie, Bereich Immunologie der Sektion Biowissenschaften, Karl-Marx-Universität Leipzig.
Otto
U
U
Keitel
R
R
Klötzer
B
B
Schürer
K D
KD
Walther
J
J
Vogt
S
S
Ambrosius
H
H
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD
Erste Erfahrungen zur Abstossungsdiagnostik nach klinischer Herztransplantation. Der Nachweis transplantatgerichteter aktivierter T-Zellen.