title: [Cyclosporin in dermatology].
abstract: Cyclosporin is a potent immunosuppressive agent with a selective and reversible inhibitory effect on helper T lymphocytes functions mainly interleukin-2 production. Cyclosporin has no myelotoxic, mutagenic or teratogenic effect. The drug is effective in preventing organ rejection, as well as in various auto-immune and inflammatory diseases. In dermatology the drug is extremely effective in psoriasis. Low doses (less than 5 mg/kg per day) have to be used to decrease the risk of nephrotoxicity and hypertension.
authors.affiliation: Clinique de dermatologie, Hôpital cantonal universitaire, Genève.
authors.forename: D
authors.initials: D
authors.lastname: Salomon
authors.forename: B
authors.initials: B
authors.lastname: Halioua
mesh_terms: D003524:Cyclosporins / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D003524:Cyclosporins
vernacular_title: La cyclosporine en dermatologie.