title: Influence of folate status and polyphenol intake on thiamin status of Irish women.
abstract: The relationship of folate status and polyphenol intake to thiamin status was studied in 80 randomly selected elderly and young Irish women, with key variables affecting thiamin nutrition controlled for. Folate, thiamin, and polyphenol intakes were measured during a 4-wk baseline (elderly and young) and 6-wk double-blind (elderly) supplementation period. Only elderly subjects were randomly assigned to placebo, folic acid (400 micrograms), thiamin (10 mg), or folic-acid-plus-thiamin groups. Thiamin status (TPP effect) was not affected by folate status (plasma and erythrocyte folate) during the baseline period or with folic acid supplementation alone. Polyphenol intake was not correlated with thiamin status. Only thiamin intake and thiamin supplementation significantly affected thiamin status. Because the majority of subjects (102 of 160) were initially thiamin deficient, enrichment of Irish grain products with thiamin is recommended.
authors.affiliation: Department of Nutrition, University of California, Davis 95616.
authors.forename: L J
authors.initials: LJ
authors.lastname: Smidt
authors.forename: F M
authors.initials: FM
authors.lastname: Cremin
authors.forename: L E
authors.initials: LE
authors.lastname: Grivetti
authors.forename: A J
authors.initials: AJ
authors.lastname: Clifford
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003069:Coffee; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007494:Ireland; D010636:Phenols / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D059808:Polyphenols; D013662:Tea; D013831:Thiamine / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D003069:Coffee; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D005492:Folic Acid; D013831:Thiamine