Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study.
Effects of a daily fish-oil supplement on serum lipids, apolipoproteins, and some platelet functions and hemorheologic variables were examined in 27 hyperlipidemic subjects in a randomized, controlled, double-blind, crossover fashion with an identically encapsulated vegetable oil serving as the control treatment. Despite the habitual high linoleic acid intake of the study population, significant incorporation of n-3 (omega-3) fatty acids into the serum, platelet, and erythrocyte lipids was observed after the fish-oil supplement. Ingestion of fish oil resulted in a 40% decrease in the triglyceride concentration, a 12% increase in HDL cholesterol, and a significant decrease in plasma viscosity, whereas the vegetable-oil placebo had no significant effect. We conclude that a moderate intake of fish oil (15 g/d) is a feasible treatment for hypertriglyceridemia even in patients with a background of high linoleic acid intake and that it may have a beneficial effect on several cardiovascular risk factors.
Green
P
P
Department of Internal Medicine A, Beilinson Medical Center, Petah Tikva, Israel.
Fuchs
J
J
Schoenfeld
N
N
Leibovici
L
L
Lurie
Y
Y
Beigel
Y
Y
Rotenberg
Z
Z
Mamet
R
R
Budowski
P
P
D001053:Apolipoproteins / Q000097:blood; D001792:Blood Platelets / Q000502:physiology; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D004907:Erythrocyte Deformability; D005227:Fatty Acids / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D007557:Israel; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage; D008055:Lipids / Q000097:blood; D010974:Platelet Aggregation; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D005227:Fatty Acids; D005395:Fish Oils; D008041:Linoleic Acids; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D019787:Linoleic Acid