Transitory models of experimentally induced intraocular pressure changes in the rabbit. A reappraisal.
The purpose of this study was to evaluate the relationship between inducer dosage, animal weight, and kinetics intraocular pressure (IOP) changes in three transitory-induced models for antiglaucoma drugs screening: oral water-loading, 5% glucose intravenous administration, and 20% NaCl infusion. For these models, a dose-dependent elevation of IOP was observed in three weight groups of rabbits (1, 2.2, and 3.8 kg). Dose-effect relationships were established, considering for each weight group two relevant parameters: maximal IOP changes and areas under or upper the kinetic curves of IOP changes. Among the three models studied, our results led us to consider water-loading as a weight-independent model, allowing us to compare results obtained by this model in New Zealand rabbits with different ages (40-150 days) or weights (0.9-3.8 kg).
Hariton
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Laboratoires Martinet, Paris, France.
Marce
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Debon
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D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000502:physiology*; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D012965:Sodium Chloride; D005947:Glucose