title: (D, L) polylactide microspheres as embolic agent. A preliminary study.
abstract: Owing to their shape, accurately calibrated microspheres appear to be very suitable material for distal embolization. Moreover, the biocompatible (D, L) polyactide (PLA) microspheres possess two other valuable advantages: easy adjustment of their biodegradation rate, and incorporation of chemotherapeutic agents during their production. The authors describe the preparation of these (D, L) PLA microspheres and their clinical applications as a preliminary step to arterial chemoembolization.
authors.affiliation: Department of Neuroradiology, University of Liège, Sart Tilman, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Flandroy
authors.forename: C
authors.initials: C
authors.lastname: Grandfils
authors.forename: J
authors.initials: J
authors.lastname: Collignon
authors.forename: A
authors.initials: A
authors.lastname: Thibaut
authors.forename: N
authors.initials: N
authors.lastname: Nihant
authors.forename: S
authors.initials: S
authors.lastname: Barbette
authors.forename: R
authors.initials: R
authors.lastname: Jerome
authors.forename: P
authors.initials: P
authors.lastname: Teyssie
mesh_terms: D000368:Aged; D001672:Biocompatible Materials; D002292:Carcinoma, Renal Cell / Q000556:secondary / Q000628:therapy; D004621:Embolization, Therapeutic / Q000379:methods; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000628:therapy; D008579:Meningioma / Q000628:therapy; D008863:Microspheres; D008875:Middle Aged; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000627:therapeutic use*; D013125:Spinal Neoplasms / Q000556:secondary / Q000628:therapy; D013242:Sterilization
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)