[The adenohypophyseal response and effect of GnRh (Dirigestran inj. Spofa) administration in cows in the postpartum period].
Radioimmunological investigation (RIA) of the level of pituitary FSH in the peripheral blood of cows after parturition demonstrated that this level increased successively. The FSH value of 32.93 +/- 3.71 ng per 1 ml, recorded the fourth to sixth day post partum, increased to as much as 57.78 +/- 40.98 ng per 1 ml 40 days after parturition. The LH level changed only slightly over the same period (from 1.12 +/- 0.21 ng per ml to 1.72 +/- 1.15 ng per ml). The concentration of progesterone in the blood of the cows was about 0.40 ng per ml during the first 15 days after parturition, but from the 25th day post partum it trebled, on an average (1.53 +/- 1.19 - 1.59 +/- 1.25 ng per ml). The response of the adenohypophysis of the cows to the administration of 200 micrograms of synthetic gonadoreline (spec. Dirigestran inj. Spofa) increased with increasing length of time from parturition. FSH concentration increased less markedly during the first 28 days p.p. and this increase was not uniform in time (the average increase was 1.5 to three times); in the later period the highest increase 300-500% was recorded, as a rule, 120 minutes after GnRH administration. The situation was similar in the increase in LH concentration in peripheral blood, but after the 26th day post partum the average increase in LH accounted for 500 to 600%. The concentration of progesterone in peripheral blood increased by more than 300%, on an average, from the 25th day after parturition. This testifies to the first post partum ovulation and to the formation of a new yellow body in the majority of cows under study.(ABSTRACT TRUNCATED AT 250 WORDS)
Kudlác
E
E
Vysoká skola veterinární, Brno.
Píchová
D
D
D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000517:prevention & control; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D010048:Ovarian Cysts / Q000517:prevention & control / Q000662:veterinary; D049590:Postpartum Period / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011644:Puerperal Disorders / Q000517:prevention & control / Q000662:veterinary
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone
Responze adenohypofýzy a úcinnost aplikace syntetického GnRH (Dirigestran inj. Spofa) u krav post partum.