title: Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
authors.forename: D S
authors.initials: DS
authors.lastname: Karanewsky
authors.forename: M C
authors.initials: MC
authors.lastname: Badia
authors.forename: C P
authors.initials: CP
authors.lastname: Ciosek
authors.forename: J A
authors.initials: JA
authors.lastname: Robl
authors.forename: M J
authors.initials: MJ
authors.lastname: Sofia
authors.forename: L M
authors.initials: LM
authors.lastname: Simpkins
authors.forename: B
authors.initials: B
authors.lastname: DeLange
authors.forename: T W
authors.initials: TW
authors.lastname: Harrity
authors.forename: S A
authors.initials: SA
authors.lastname: Biller
authors.forename: E M
authors.initials: EM
authors.lastname: Gordon
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000096:biosynthesis*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000924:Anticholesteremic Agents; D002087:Butyrates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D009943:Organophosphorus Compounds; C066279:SQ 33600; D002784:Cholesterol