title: Smooth muscle tumours of the alimentary tract.
abstract: Neoplasms arising from smooth muscle of the gastrointestinal (GI) tract are uncommon, comprising only 1% of gastrointestinal tumours. A total of 51 cases of smooth muscle tumour of the GI tract were analysed; 44 leiomyomas and 7 leiomyosarcomas. Lesions occurred in all areas from the oesophagus to the rectum, the stomach being the commonest site. Thirty-six patients had clinical features referable to the tumour. The tumour was detected during investigation or management of an unrelated disease process in 15 patients. The clinical presentation varied depending on tumour location, but abdominal pain and GI bleeding were the commonest presenting symptoms. The lesion was demonstrated preoperatively, mainly by endoscopy and barium studies, in 27 patients. Surgical excision was the treatment of choice, where possible. There was no recurrence in the leiomyoma group but four patients died in the leiomyosarcoma group. Although rare, smooth muscle tumours should be considered in situations where clinical presentation and investigations are not suggestive of any common GI disorder. The preoperative assessment and diagnosis is difficult because of the variability in clinical features and their inaccessibility to routine GI investigation. It is recommended that, where possible, the lesion, whether symptomatic or discovered incidentally, should be excised completely to achieve a cure and prevent future complications.
authors.affiliation: Department of Surgery, Queen's University of Belfast, Belfast City Hospital, Northern Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Diamond
authors.forename: M H
authors.initials: MH
authors.lastname: Danton
authors.forename: T G
authors.initials: TG
authors.lastname: Parks
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D004067:Digestive System Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery*; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors