Inoculation of Macaca fascicularis with simian immunodeficiency virus, SIVmne immunologic, serologic, and pathologic changes.
Previous studies had tested the susceptibility of two macaque species, Macaca nemestrina and M. mulatta, to infection with the primate lymphotropic lentivirus SIVmne. In this report we describe the results obtained after infecting eleven M. fascicularis with SIVmne. Six of the animals had previously been immunized with a recombinant vaccinia virus expressing the envelope gene of HIV-1. All eleven animals became seropositive. To date ten animals have died 43 to 155 weeks post infection of an AIDS-like disease.
Kuller
L
L
Regional Primate Research Center, University of Washington, Seattle.
Morton
W R
WR
Benveniste
R E
RE
Tsai
C C
CC
Clark
E A
EA
Gale
M J
MJ
Hu
S L
SL
Thouless
M E
ME
Katze
M G
MG
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D015151:Immunoblotting; D008252:Macaca fascicularis; D012703:Serotyping; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000302:isolation & purification; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014616:Vaccinia virus; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D014614:Vaccines, Synthetic; D014765:Viral Vaccines