Effects of loreclezole on metrazol-induced phenomena in developing rats.
A potential antiepileptic drug, loreclezole, was studied in rats of 7, 12, 18, 25 and 90 days old. Metrazol-induced motor phenomena served as a model. Loreclezole did not consistently influence isolated myoclonic jerks or minimal metrazol seizures (predominantly clonic with preserved righting ability). Major metrazol seizures, i.e., generalized tonic-clonic seizures, were suppressed by loreclezole in a dose-dependent manner in all age-groups, except in the 7 day old group where outlined changes did not reach statistical significance. Severity of seizures was significantly diminished at all developmental stages studied. Loreclezole exhibits nearly the same profile of action as phenytoin and carbamazepine in this model.
Pohl
M
M
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Mares
P
P
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D014230:Triazoles / Q000494:pharmacology*
D000927:Anticonvulsants; D014230:Triazoles; C066440:loreclezole; D010433:Pentylenetetrazole