[Stimulation of the synthesis of C-reactive protein using pyrogenal in non-neoplastic diseases and cancer of the lungs].
Method of immunodiffusion titration of rabbit monospecific antiserum (The I. M. Mechnikov Central Research Institute of Vaccines and Sera of the USSR Ministry of Health) in agar was used to measure blood C-reactive protein (C-RP) level in patients with acute pneumonia (32), protracted pneumonia or activation of chronic non-specific lung pathology (101) and lung cancer (153) after a 3-4-week course of complex antiinflammatory treatment and a 10-14-day course of immunostimulation with pyrogenal (The N. F. Gamaleya Research Institute of Epidemiology and Microbiology). A decrease in the incidence (from 81.2% to 14.2%) and level (from 1.4 +/- 0.3 to 0.3 +/- 0.03 mg%) of C-RP was observed in cases of non-tumor pathology whereas in patients with lung cancer those values rose in step with tumor progression (from 72.2% and 0.4 +/- 0.07 mg% at stage I to 96.3% and 1.2 +/- 0.12 mg% at stage IV). Treatment with pyrogenal allowed to identify C-RP in patients with false-negative reaction in all subgroups. Two-week dynamic C-RP curves characterizing non-tumor and tumor pathology of the lung were plotted.
Sukharev
A E
AE
Iliukhina
L E
LE
Vorob'ev
A I
AI
Talukder
N A
NA
Mustafin
D G
DG
Ermolaeva
T N
TN
Babenko
O A
OA
Trubnikov
G A
GA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000628:therapy*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D011014:Pneumonia / Q000188:drug therapy / Q000628:therapy*; D013268:Stimulation, Chemical
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; C009136:pyrogenal; D002097:C-Reactive Protein
Stimuliatsiia sinteza C-reaktivnogo proteina pirogenalom pri nezlokachestvennykh zabolevaniiakh i rake legkikh.