title: Early assessment of coronary reserve after bypass surgery by dipyridamole transesophageal echocardiographic stress test.
abstract: The evaluation of coronary reserve within a few hours of aortocoronary bypass surgery could be of extreme utility for the follow-up or therapeutical management of these patients. In 11 men patients who underwent aortocoronary bypass surgery, a dipyridamole echocardiography stress test was carried out before (1 to 3 days), early after (68 to 130 minutes), and 1 week after surgery. The first and third tests were performed using a standard transthoracic approach, while the second was performed by a transesophageal approach. Dipyridamole was administered intravenously at a dose of 0.56 mg/kg body weight (low dose) and eventually adding 0.28 mg/kg body weight (high dose), always in the absence of antiischemic therapy. An arbitrary wall motion score (0 = eukinesia; 1 = hypokinesia; 2 = akinesia; 3 = dyskinesia) was assigned to the seven different myocardial regions in which the left ventricle was divided in order to have a semiquantitative score. Under basal conditions wall motion score per patient in the three series of tests did not change significantly (1.6, 1.4, and 1.5, respectively), while the mean score during dipyridamole administration showed significant differences (3.6, 1.9, and 1.9, respectively), indicative of the results obtained by surgical repair. The test, positive in all patients before surgery, showed wall motion abnormalities and ischemic ECG changes in two patients immediately after surgery by the transesophageal approach. One patient who had a normal basal contraction pattern and an abnormal response after the test developed in the following days a perioperative myocardial infarction, while a second patient in the follow-up period developed low-level effort angina.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: C.N.R. Institute of Clinical Physiology, Cardiosurgical Department, University of Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Biagini
authors.forename: S
authors.initials: S
authors.lastname: Maffei
authors.forename: M
authors.initials: M
authors.lastname: Baroni
authors.forename: M
authors.initials: M
authors.lastname: Levantino
authors.forename: C
authors.initials: C
authors.lastname: Comite
authors.forename: V
authors.initials: V
authors.lastname: Russo
authors.forename: L
authors.initials: L
authors.lastname: Salerno
authors.forename: G
authors.initials: G
authors.lastname: Borzoni
authors.forename: M
authors.initials: M
authors.lastname: Piacenti
authors.forename: L
authors.initials: L
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology*; D004176:Dipyridamole; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D011184:Postoperative Period; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D004176:Dipyridamole