title: Treatment of psoriatic arthritis with oral 1,25-dihydroxyvitamin D3: a pilot study.
abstract: We conducted a 6-month open-label trial in which 10 patients with active psoriatic arthritis received 2 micrograms of oral 1,25-dihydroxyvitamin D3 daily. Statistically significant improvement was noted in the tender joint count and physician global impression. Of these 10 patients, 4 had substantial (greater than or equal to 50%) improvement, and 3 had moderate (greater than or equal to 25%) improvement in the tender joint count. Two patients were unable to receive therapeutic doses because of hypercalciuria. High-dose vitamin D may be a useful therapeutic agent for psoriatic arthritis.
authors.affiliation: Boston University Arthritis Center, Massachusetts.
authors.forename: D
authors.initials: D
authors.lastname: Huckins
authors.forename: D T
authors.initials: DT
authors.lastname: Felson
authors.forename: M
authors.initials: M
authors.lastname: Holick
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D002117:Calcitriol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002118:Calcium / Q000652:urine; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D002117:Calcitriol; D002118:Calcium