Kinetics of the trypsinogen activation by enterokinase and trypsin.
A global kinetic analysis of the mechanisms of the trypsinogen activation by enterokinase and trypsin is presented. The kinetic equations of both the transient-phase and the steady-state of these mechanisms are presented. In addition, we here derive the corresponding kinetic equations for the case in which the condition of rapid equilibrium prevails and we propose a kinetic data analysis. The significance of this approach to the treatment of other zymogen activation processes is discussed.
Varón
R
R
Biochemisches Institut, Christian Albrechts Universität zu Kiel, West Germany.
Havsteen
B H
BH
Vázquez
A
A
García
M
M
Valero
E
E
García Cánovas
F
F
D000818:Animals; D004765:Enteropeptidase / Q000378:metabolism*; D004789:Enzyme Activation; D007700:Kinetics; D008954:Models, Biological; D013223:Statistics as Topic; D014357:Trypsin / Q000378:metabolism*; D014362:Trypsinogen / Q000378:metabolism*
D014362:Trypsinogen; D014357:Trypsin; D004765:Enteropeptidase