IgE-positive epidermal Langerhans cells in allergic contact dermatitis lesions provoked in patients with atopic dermatitis.
To see whether or not IgE-bearing epidermal Langerhans cells are specific to skin lesions of atopic dermatitis (AD), we performed immunohistochemical and immunoelectron microscopic examinations of dinitro-chlorobenzene (DNCB) contact dermatitis lesions provoked in uninvolved skin of eight patients with AD. In all of the eight examined, IgE-positive epidermal Langerhans cells were observed in the DNCB dermatitis lesions. Typical staining of anti-IgE was absent in the epidermis of normal-appearing skin of five patients with AD. Thus, it is likely that IgE positive epidermal Langerhans cells non-specifically occur in different eczematous diseases provoked in patients with AD.
Sugiura
H
H
Department of Dermatology, Shiga University of Medical Science, Otsu, Japan.
Uehara
M
M
Maeda
T
T
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000150:complications*; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D004137:Dinitrochlorobenzene; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D016253:Microscopy, Immunoelectron
D004137:Dinitrochlorobenzene; D007073:Immunoglobulin E