title: Chronic recurrent aphthous stomatitis: oral treatment with low-dose interferon alpha.
abstract: Recombinant human interferon alfa-2a (HuIFN alpha) was administered orally once daily in a low concentration (1,200 IU/day) to nine patients with chronic recurrent aphthous stomatitis (RAS), and a placebo solution was given to 10 control chronic RAS patients in a double-blind study. All HuIFN alpha-treated patients had total remission of their aphthae within a 2-week period, while placebo control patients had no change in their condition. The 10 placebo control patients were then treated with HuIFN alpha in a manner identical to that used for the initial principal group. Within a 2-week period, all original placebo patients had complete remission of their aphthae. Eleven of the patients did not have a recurrence of RAS during a subsequent 6-month observation period. Eight patients had recurring aphthae; however, the lesions were resolved by retreating with oral HuIFN alpha for less than 1 week.
authors.affiliation: Amarillo Virology Research, Texas 79106.
authors.forename: V A
authors.initials: VA
authors.lastname: Hutchinson
authors.forename: J L
authors.initials: JL
authors.lastname: Angenend
authors.forename: W L
authors.initials: WL
authors.lastname: Mok
authors.forename: J M
authors.initials: JM
authors.lastname: Cummins
authors.forename: A B
authors.initials: AB
authors.lastname: Richards
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000628:therapy*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins