[Prevention of progression of coronary atherosclerosis by drug and diet therapy].
In 102 patients with ischemic heart disease the severity of stenosis was classified into 7 grades (0, 25, 50, 75, 90, 99, 100%) in accordance with the AHA reporting system. The coronary angiograms were compared at first and second catheterization (intervals 2-84 months) and progression was considered present if the stenosis in the second study showed more than one grade increase in comparison with the first study. Fifty six patients met criteria for progression. Risk factors were obtained within the first second catheterization. Drug and diet therapy were evaluated by interview. No significant difference could be found between the progression (P) group and the nonprogression (N) group in relation to family history and obesity. A history of hypertension was more common in the P group. In respect to blood sampling, the values of total cholesterol, Apo B, CII, E and Apo B/AI were significantly higher in the P group than those in the N group at first and second catheterization. The percentage of patients showing abnormal levels of blood sugar and lipid were higher in the P group than the N group although the percentage of patients with drug and diet therapy were higher in the P group than in the N group. The percentage of patients with diet therapy for hyperglycemia and hyperlipidemia were higher in the P group, however weight increase was more common in the P group. These data suggest that sufficient diet and drug therapy is necessary for patients with risk factors.
Satomura
K
K
First Department of Medicine, National Defense Medical College.
Mizuno
K
K
Shibuya
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy / Q000188:drug therapy; D006949:Hyperlipidemias / Q000178:diet therapy / Q000188:drug therapy; D006973:Hypertension / Q000178:diet therapy / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012307:Risk Factors