Lack of interaction between famotidine and warfarin.
In eight healthy male volunteers taking daily subtherapeutic doses of warfarin (mean daily dose = 4.0 mg), the addition of famotidine 40 mg once-a-day for seven days did not alter the prothrombin time profile, thrombotest coagulation time or total warfarin steady-state plasma concentration. Plasma peak concentration, time to peak concentration and area under curve for famotidine were not affected by the co-administration of warfarin. However the plasma half-life of famotidine was slightly, but statistically significantly longer (p less than 0.05) during maintenance treatment with warfarin (mean +/- s.e.m.: 2.58 +/- 0.14 h versus 2.96 +/- 0.16 h respectively).
De Lepeleire
I
I
Department of Pharmacology and Clinical Pharmacology, University of Leuven, School of Medicine, Belgium.
Van Hecken
A
A
Verbesselt
R
R
Tjandra-Maga
T B
TB
Buntinx
A
A
Distlerath
L
L
De Schepper
P J
PJ
D000328:Adult; D004347:Drug Interactions; D015738:Famotidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006706:Homeostasis; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D013997:Time Factors; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D014859:Warfarin; D015738:Famotidine