Steroid hormone receptors in pelvic muscles and ligaments in women.
Using monoclonal antibody assay techniques estrogen receptors (ER) and progesterone receptors (PgR) were quantitated in female pelvic floor muscles, urogenital ligaments and uterus (myometrium). Receptors were detected in all these structures. In addition qualitative assessment showed distinct nuclear staining in the same structures. ER and PgR were not found in the musculus rectus abdominis with either method. The findings provide a rationale for estrogen treatment in women with urogenital disorders.
Smith
P
P
Department of Obstetrics and Gynecology, Uppsala University, Akademiska Sjukhuset, Sweden.
Heimer
G
G
Norgren
A
A
Ulmsten
U
U
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009132:Muscles / Q000737:chemistry*; D009215:Myometrium / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012404:Round Ligament of Uterus / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone