title: [Bilateral adrenal pheochromocytoma. Diagnosis and follow-up using the clonidine test and measurement of plasma neuropeptide Y concentration].
abstract: The role of the clonidine suppression test and determination of the plasma concentration of noradrenaline and of neuropeptide Y (NPY) for the diagnosis and monitoring of bilateral pheochromocytoma was studied in a ten year old girl. Prior to tumor removal plasma concentration of noradrenaline (25.9 nmol/l) and NPY (14 pmol/l) were markedly elevated. Inhibition of central sympathetic activity by clonidine (150 micrograms orally) did not lower the plasma concentration of noradrenaline (70.4 nmol/l) and NPY (52.6 pmol/l). However in an adolescent boy with renal hypertension plasma concentration of noradrenaline and NPY fell following clonidine application (noradrenaline from 1.9 to 1.3 nmol/l, NPY from 3.6 to 2.4 pmol/l). After complete removal of the pheochromocytoma noradrenaline and NPY fell back to normal.
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin (GHS) Essen.
authors.forename: S
authors.initials: S
authors.lastname: Eisenhut
authors.forename: W
authors.initials: W
authors.lastname: Rascher
authors.forename: R E
authors.initials: RE
authors.lastname: Lang
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis*; D002648:Child; D003000:Clonidine; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000175:diagnosis*; D009478:Neuropeptide Y / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D010673:Pheochromocytoma / Q000097:blood / Q000175:diagnosis*
chemical_list: D009478:Neuropeptide Y; D003000:Clonidine; D009638:Norepinephrine
vernacular_title: Bilaterales adrenales Phäochromozytom. Diagnostik und Verlaufskontrolle mittels Clonidintest und Messung der Plasmakonzentration von Neuropeptid Y.