title: Attentional markers of vulnerability to schizophrenia: performance of medicated and unmedicated patients and normals.
abstract: Medicated and unmedicated schizophrenic patients (both n's = 14) were compared to a normal control sample (n = 15) on two attentional tasks hypothesized to be markers of vulnerability to schizophrenia. These tasks, the continuous performance test and the visual backward masking task, were found to be more deviant in schizophrenic patients than in normals. In addition, the group mean levels of performance did not differ consistently across medication status within the medicated patients. It was found, however, that the association between these tasks varied as a function of medication status, with unmedicated patients more similar to normals than to medicated patients. The implications of these results for the two tasks as markers are discussed, with special focus on those earlier studies that did not evaluate unmedicated patients.
authors.affiliation: Dept. of Psychiatry, Mt. Sinai School of Medicine, New York, NY 10029.
authors.forename: P D
authors.initials: PD
authors.lastname: Harvey
authors.forename: R S
authors.initials: RS
authors.lastname: Keefe
authors.forename: J
authors.initials: J
authors.lastname: Moskowitz
authors.forename: K M
authors.initials: KM
authors.lastname: Putnam
authors.forename: R C
authors.initials: RC
authors.lastname: Mohs
authors.forename: K L
authors.initials: KL
authors.lastname: Davis
mesh_terms: D001288:Attention / Q000187:drug effects*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D010364:Pattern Recognition, Visual / Q000187:drug effects*; D010470:Perceptual Masking; D011930:Reaction Time / Q000187:drug effects; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics; D012565:Schizophrenic Psychology
chemical_list: D005819:Genetic Markers