title: Alteration in density of eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis.
abstract: The density of eosinophils in the cerebrospinal fluid (CSF) and blood of male ddY mice infected with Angiostrongylus cantonensis was examined on days 14, 20 and 27 post-infection (p.i.) with discontinuous Percoll gradient centrifugation. Normal blood eosinophils had a density of between 1.070 and 1.080 g ml-1. No significant changes in density in blood eosinophils were noted during the course of the observations. CSF eosinophils began to become hypodense (defined as density less than 1.070 g ml-1) on day 20 p.i., and 88% of eosinophils were hypodense on day 27. Our results suggest therefore that eosinophils probably become hypodense in the CSF and brain tissues, but not in the blood.
authors.affiliation: Department of Parasitology, Akita University School of Medicine, Japan.
authors.forename: X X
authors.initials: XX
authors.lastname: Hua
authors.forename: H
authors.initials: H
authors.lastname: Sugaya
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
mesh_terms: D000801:Angiostrongylus; D000818:Animals; D002499:Centrifugation, Density Gradient; D002555:Cerebrospinal Fluid / Q000166:cytology*; D004804:Eosinophils / Q000502:physiology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009349:Nematode Infections / Q000134:cerebrospinal fluid*