The course of Giardia muris infection in immunocompetent and immunocompromised mice.
No significant sex-related difference was observed in immunocompetent mice. Sexually mature mice of both sexes excreted large numbers of Giardia cysts over a longer period than did immature ones. Cyclosporin A has compromised the immunological response of the primary Giardia infection. However, it does not affect the ability of the immune host to resist challenge infection. The use of this drug may cause fulmination of giardiasis.
Romia
S A
SA
Department of Parasitology, Faculty of Medicine, Mansoura University, Egypt.
Abu-Zakham
A A
AA
al-Naggar
H M
HM
Atia
R A
RA
Abu-Shady
A F
AF
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D005260:Female; D005873:Giardiasis / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012727:Sex Characteristics
D003524:Cyclosporins