Sampling strategy in linkage studies of affective disorders.
Evidence of linkage in families of bipolar patients has so far been identified with genetic markers on chromosome X and 11. However, replications of these data have not consistently been reported in either case, which favours the hypothesis of genetic heterogeneity. Therefore, we have tried to outline a sampling strategy for linkage replication in affective disorders. We estimated the average number of nuclear families required to replicate X or 11 linkage as a function of the degree of heterogeneity as well as the number to prove heterogeneity given that linkage exists. The results are presented and discussed.
Leboyer
M
M
INSERM U 155, Unité de Recherches d'Epidemiologie Génétique, Paris, France.
Babron
M C
MC
Clerget-Darpoux
F
F
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006580:Genetic Carrier Screening; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D014960:X Chromosome
D005819:Genetic Markers