Effect of N-acetylneuraminic acid on respiratory tract secretion and inflammation in the bronchitic rabbit.
Long-term exposure of rabbits to SO2 gas caused the following changes in the respiratory tract system: decreases in the respiratory rate and pO2 blood level; an increase in the viscosity of sputum associated with increases in protein, unsaturated phosphatidylethanolamine and sphingomyelin; subacute rhinitis, tracheitis and multiple bronchopneumonia. Pretreatment with repeated administrations (inhalations) of N-acetylneuraminic acid remarkably prevented these inflammatory changes. The significance of this finding is discussed.
Miyata
T
T
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Ishii
T
T
Sugiyama
N
N
Okano
Y
Y
Nishi
N
N
Takahama
K
K
Ogasawara
S
S
Oda
Y
Y
Yokoyama
K
K
Murata
Y
Y
D000818:Animals; D001784:Blood Gas Analysis; D001835:Body Weight / Q000187:drug effects; D001991:Bronchitis / Q000473:pathology / Q000503:physiopathology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005227:Fatty Acids / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D019158:N-Acetylneuraminic Acid; D009929:Organ Size / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D012794:Sialic Acids / Q000494:pharmacology*; D013183:Sputum / Q000187:drug effects / Q000502:physiology; D013458:Sulfur Dioxide / Q000494:pharmacology
D005227:Fatty Acids; D012794:Sialic Acids; D013458:Sulfur Dioxide; D019158:N-Acetylneuraminic Acid; D010100:Oxygen