title: [Extrapyramidal syndrome caused by moderate overdosage of domperidone. Description of a case].
abstract: Domperidone is useful in the treatment of vomiting and gastroesophageal reflux in children. Its efficaciousness is due to the antagonist effect on gastrointestinal dopaminergic receptors. Contrary to the initial expectations, domperidone is able to penetrate into the hematoencephalic barrier and to cause adverse neurologic reactions. We report a case of extrapyramidal reaction in a child after moderate overdosage of domperidone.
authors.affiliation: Divisione di Pediatria, Ospedale Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Pellegrino
authors.forename: M
authors.initials: M
authors.lastname: Sacco
authors.forename: F
authors.initials: F
authors.lastname: Lotti
mesh_terms: D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D004294:Domperidone / Q000506:poisoning*; D006801:Humans; D007223:Infant; D008297:Male; D013577:Syndrome
chemical_list: D004294:Domperidone
vernacular_title: Sindrome extrapiramidale da moderato iperdosaggio di Domperidone. Descrizione di un caso.