[Subrenal capsule assay for chemosensitivity test of urological malignancy].
We evaluated the subrenal capsule assay with a chemosensitivity test using 47 fresh surgical explants, including 16 renal cell carcinomas and 10 uroepithelial cancers. Forty-one explants were evaluable and 166 drug tests were performed. Forty-seven tests (28.3%) were found to be sensitive. Ten of 16 renal cell carcinomas involved a sensitive drug, 3 involved more than 2 sensitive drugs. VP-16, ADM, BLM and 5-FU were the most sensitive compared with the others. Concerning the uroepithelial cancers, 8 of 10 involved a sensitive drug, 5 involved more than 2 sensitive drugs. CDDP and VP-16 were more effective than the other drugs. This result showed a good correlation with the clinical therapeutic efficacy using CDDP. In the future, we hope to evaluate the clinical correlation between clinical efficacy and this assay.
Mitsui
H
H
Department of Urology, Yamaguchi University of Medicine.
Shimabukuro
T
T
Yamamoto
M
M
Yamamoto
N
N
Sakatoku
J
J
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000473:pathology; D005260:Female; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D013370:Subrenal Capsule Assay; D014571:Urologic Neoplasms / Q000473:pathology*
D000970:Antineoplastic Agents