title: Influence of gluten-derived fractions on chemiluminescence production by human neutrophils.
abstract: The effects of gliadin and glyc-gli on leukocyte chemiluminescence response were assessed in vitro. A dose-dependent increase in chemiluminescence response of neutrophils stimulated by zymosan was observed by using gliadin at concentrations ranging between 1 and 20 micrograms. By increasing glyc-gli concentration, a bimodal response was observed with an enhancement up to 50 micrograms/ml, followed by suppressive effects, which were again dose-dependent. The possible implications of these findings in human pathology are discussed.
authors.affiliation: Laboratorio Nefrologia e Immunoematologia NAM, Università di Torino, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Roccatello
authors.forename: M C
authors.initials: MC
authors.lastname: Amprimo
authors.forename: R
authors.initials: R
authors.lastname: Coppo
authors.forename: G
authors.initials: G
authors.lastname: Cavalli
authors.forename: G
authors.initials: G
authors.lastname: Quattrocchio
authors.forename: B
authors.initials: B
authors.lastname: Gianoglio
authors.forename: A
authors.initials: A
authors.lastname: Ferrero
authors.forename: C
authors.initials: C
authors.lastname: di Mauro
authors.forename: L M
authors.initials: LM
authors.lastname: Sena
authors.forename: G
authors.initials: G
authors.lastname: Piccoli
mesh_terms: D002446:Celiac Disease / Q000209:etiology; D005609:Free Radicals; D005903:Gliadin / Q000494:pharmacology; D005922:Glomerulonephritis, IGA / Q000209:etiology; D005983:Glutens / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism
chemical_list: D005609:Free Radicals; C066008:glyc-gli (gluten fraction); D005983:Glutens; D005903:Gliadin; D010100:Oxygen