title: Metabolism of beta-methyl-heptadecanoic acid in the perfused rat heart and liver.
abstract: The metabolism of beta-methyl-[1-14C]heptadecanoic acid, a potential myocardial imaging agent, was investigated in perfused hearts and livers from rats. Hepatic uptake is approximately 4.5 times greater than cardiac uptake. In the heart, 66% of beta-methyl-heptadecanoic acid metabolism occurs via omega-oxidation, 33% by esterification and less than 1% via alpha-oxidation. In contrast, 53% of hepatic metabolism of beta-methyl-heptadecanoic acid occurs via alpha-oxidation, 27% via omega-oxidation, and 20% via esterification. Perfusion of hearts and livers with concentrations of beta-methyl-heptadecanoic acid 100 to 1000 times greater than that used for myocardial imaging does not alter any of the physiological and biochemical parameters measured. In the perfused liver, 3-methyl-[1-14C]glutarate was identified as the principal hydrosoluble catabolite of beta-methyl-heptadecanoic acid.
authors.affiliation: Department of Biochemistry, University of Montreal, Canada.
authors.forename: G D
authors.initials: GD
authors.lastname: Fink
authors.forename: J A
authors.initials: JA
authors.lastname: Montgomery
authors.forename: F
authors.initials: F
authors.lastname: David
authors.forename: M
authors.initials: M
authors.lastname: Garneau
authors.forename: E
authors.initials: E
authors.lastname: Livni
authors.forename: D
authors.initials: D
authors.lastname: Elmaleh
authors.forename: H W
authors.initials: HW
authors.lastname: Strauss
authors.forename: H
authors.initials: H
authors.lastname: Brunengraber
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000009:adverse effects / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging; D066298:In Vitro Techniques; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005227:Fatty Acids; C033637:3-methylheptadecanoic acid