Differences in ischaemic myocardial potassium leakage after treatment with the calcium antagonist anipamil or the beta-blocker atenolol.
The abilities of the new calcium antagonist anipamil as well as the beta-blocker atenolol to reduce the amount of K+ released into the extracellular space during the first minutes of acute coronary artery occlusion were investigated in anaesthetized pigs. [K+]e was continuously measured epicardially with ion selective electrodes. Immediately after starting an occlusion [K+]e rose steeply from normal plasma levels of 3.5 mmol/l to values about three times as high at the end of the 6-min occlusion. This was reproducible in a second and third occlusion in the untreated control group. In the treatment groups either anipamil (0.5; 1.0 mg/kg) or atenolol (0.3 mg/kg) were injected intravenously 10 min before the second occlusion. Anipamil inhibited K+ loss into the extracellular space dose relatedly and significantly throughout the 6-min occlusion period, whereas atenolol showed no protection. The cardioprotective effect of anipamil was also demonstrated in a third occlusion 60 min post application. This different profile cannot be explained by differences in the ability of the two drugs to lower myocardial oxygen consumption; indeed this was only achieved after atenolol. It is concluded that anipamil exerted a direct protective effect on the cardiac myocyte level during ischaemia.
Kirchengast
M
M
Department of Cardiovascular Pharmacology, Knoll AG, Ludwigshafen/Rhein Fed. Rep. of Germany.
D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003327:Coronary Disease / Q000378:metabolism* / Q000503:physiopathology; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology*; D013552:Swine
D002121:Calcium Channel Blockers; D011437:Propylamines; D001262:Atenolol; C045313:anipamil; D011188:Potassium