Effects of multiple dose infections with Ascaris suum on blood gastrointestinal hormone levels in pigs.
Ten consecutive daily doses of infective Ascaris suum eggs were administered to pigs in two experiments and the levels of gastrointestinal hormones in their blood were measured. The piglets in each experiment were divided into low-dose (LDI) and high-dose (HDI) infections and control groups. Infected pigs had lower feed consumption, lower weight gains, and lower feed efficiency than control pigs. Serum gastrin levels in infected pigs were significantly lower than the controls from Days 7 to 17 post first inoculation (PFI), and so were their serum glucagon levels from Days 12 to 24 PFI. Serum insulin levels in infected animals were sometimes lower than those in controls. These differences were usually more intense in the LDI pigs than in HDI pigs. The plasma cholecystokinin (CCK) levels in the LDI group were significantly higher than those in controls from Day 10 PFI to the end of the experiment, while the CCK levels in the HDI group did not differ significantly from the controls. Increased plasma CCK levels could be a satiety factor in A. suum infection since the time of occurrence of high levels of CCK matched the period of reduced feed consumption.
Yang
S
S
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN.
Gaafar
S M
SM
Bottoms
G D
GD
D000818:Animals; D001196:Ascariasis / Q000097:blood / Q000469:parasitology / Q000662:veterinary*; D001200:Ascaris; D002766:Cholecystokinin / Q000097:blood; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D011863:Radioimmunoassay / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000097:blood* / Q000469:parasitology
D005755:Gastrins; D005768:Gastrointestinal Hormones; D007328:Insulin; D005934:Glucagon; D002766:Cholecystokinin