title: N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia.
abstract: The hippocampal lesion induced by cerebral ischemia has several excitotoxic features. Denervation of the ischemia-vulnerable pyramidal cells has a protective effect. Because most synapses are glutamatergic, administration of glutamate antagonists after ischemia also could be protective. Growing evidence now indicates that non-N-methyl-D-aspartate antagonists are more effective than N-methyl-D-aspartate antagonists in complete global ischemia. One explanation offered is that ischemia may sensitize pyramidal neurons so that "normal" postischemic synaptic activity induces lethal damage.
authors.affiliation: Institute of Neuropathology, University of Copenhagen, Denmark.
authors.forename: N H
authors.initials: NH
authors.lastname: Diemer
authors.forename: F F
authors.initials: FF
authors.lastname: Johansen
authors.forename: M B
authors.initials: MB
authors.lastname: Jørgensen
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D005971:Glutamates; D016202:N-Methylaspartate