[The antimicrobial action of the xanthine oxidase-xanthine system on the causative agent of cholera].
As revealed in experiments on V. cholerae, the enzymatic link xanthine oxidase-xanthine produces a vibriostatic effect at the concentration of xanthine oxidase equal to 0.0125 g/l and a vibriocidal effect at the concentration of xanthine oxidase equal to 0.025 g/l in a medium with pH 7.5-7.6. In the presence of protein the antivibrionic activity of the xanthine oxidase link is decreased. The introduction of bivalent iron into the enzymatic link xanthine oxidase-xanthine enhances its vibriocidal action on V. cholerae.
Adamov
A K
AK
Pavlova
Iu P
IuP
D000818:Animals; D000900:Anti-Bacterial Agents; D001798:Blood Proteins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D007501:Iron / Q000494:pharmacology; D011817:Rabbits; D012996:Solutions; D014734:Vibrio cholerae / Q000187:drug effects*; D019820:Xanthine; D014969:Xanthine Oxidase / Q000494:pharmacology*; D014970:Xanthines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D012996:Solutions; D014970:Xanthines; D019820:Xanthine; D007501:Iron; D014969:Xanthine Oxidase
Antimikrobnoe deĭstvie sistemy ksantinoksidaza--ksantin na vozbuditel' kholery.