title: Partial hepatectomy and mediators of inflammation decrease the expression of liver alpha 2-HS glycoprotein gene in rats.
abstract: Liver mRNA levels of two acute phase reactant (APR) proteins, alpha 2-HS glycoprotein (a major negative APR) and alpha 1-acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of alpha 2-HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of alpha 1-acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of alpha 2-HS glycoprotein induced by the acute-phase response following inflammatory mediators and partial hepatectomy are due to a down-regulation of the gene expression of this protein in rat liver.
authors.affiliation: INSERM Unité 78, BP 73, 76233 Bois-Guillaume, France.
authors.forename: M
authors.initials: M
authors.lastname: Daveau
authors.forename: C
authors.initials: C
authors.lastname: Davrinche
authors.forename: N
authors.initials: N
authors.lastname: Djelassi
authors.forename: J
authors.initials: J
authors.lastname: Lemetayer
authors.forename: N
authors.initials: N
authors.lastname: Julen
authors.forename: M
authors.initials: M
authors.lastname: Hiron
authors.forename: P
authors.initials: P
authors.lastname: Arnaud
authors.forename: J P
authors.initials: JP
authors.lastname: Lebreton
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D005353:Fibronectins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D005796:Genes / Q000187:drug effects; D006498:Hepatectomy; D007249:Inflammation; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014425:Turpentine
chemical_list: D005353:Fibronectins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D014425:Turpentine