Effect on breathing of raising end-expiratory lung volume in sleeping laryngectomized man.
In animals, tonic vagal activity from lung receptors provides a means by which changes in end-expiratory lung volume can influence respiratory timing. We wished to examine whether increasing the end-expiratory lung volume within the tidal volume range had a similar effect in man. In order to minimize behavioral influences on breathing, the study was performed in subjects during deep non-rapid eye movement sleep. Five laryngectomized subjects were chosen for the study since their permanent tracheal stomata allow simple, airtight connection to respiratory apparatus and avoided problems with glottic closure. During EEG-documented sleep, end-expiratory volume was increased by up to 350 ml with the addition of expiratory threshold loads of 1 to 10 cm H2O. End-expiratory volume increased linearly with expiratory pressure. Inspiratory and expiratory times (TI and TE) were not affected by increases in end-expiratory volume. Tidal volume (VT) was decreased such that end-inspiratory volume remained unchanged. The decrease in VT may result from a reduction in inspiratory muscle efficiency at a higher lung volume. The results of the study provide no evidence that tonic vagal afferent information from the lungs is important in controlling respiratory rhythm within the tidal volume range in man when behavioral control of breathing is minimized.
Hamilton
R D
RD
Department of Medicine, Charing Cross and Westminster Medical School, London, U.K.
Horner
R L
RL
Winning
A J
AJ
Guz
A
A
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D000368:Aged; D006801:Humans; D007825:Laryngectomy; D008168:Lung / Q000294:innervation / Q000502:physiology*; D008297:Male; D008722:Methods; D008875:Middle Aged; D012890:Sleep; D014109:Total Lung Capacity / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology