title: Adaptive hyperphagia in patients with postsurgical malabsorption.
abstract: The specific nutritional consequences of malabsorption after small-bowel surgery were studied in a consecutive series of 48 ambulatory patients who had had small-bowel resection (n = 43) or bypass (n = 5) and in 10 patients who had an ileal pouch (n = 10). The patients received a 3-day standardized oral regimen providing daily 30 kcal/kg of ideal body weight (IBW). Throughout the study, 41 patients had malabsorption (fecal fat greater than 5%); 17 had fecal fat less than 5% and served as controls. The malabsorption patients absorbed 70% of protein and 71% of fat. Twenty-one were normonourished and 20 had features of mild energy malnutrition, vs. 15 and 2 controls, respectively. Compared with controls, malabsorption patients had decreased body weight and triceps skin-fold but no features of protein malnutrition. their mean daily food intake at home was significantly enhanced (39.6 +/- 13.1 kcal/IBW kg) vs. controls (28.8 +/- 5.8 kcal/IBW kg, P less than 0.001). In the malabsorption group, caloric intake was higher in the normonourished patients than in those with mild malnutrition. This study shows that a chronic malabsorption has limited nutritional consequences. The patients compensate for their absorptive handicap by increasing their oral intake.
authors.affiliation: Service d'Hépatogastroentérologie, Hôpital Rothschild, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Cosnes
authors.forename: P
authors.initials: P
authors.lastname: Lamy
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: M
authors.initials: M
authors.lastname: Le Quintrec
authors.forename: J P
authors.initials: JP
authors.lastname: Gendre
authors.forename: Y
authors.initials: Y
authors.lastname: Le Quintrec
mesh_terms: D000042:Absorption; D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000493:pharmacokinetics; D004044:Dietary Proteins / Q000493:pharmacokinetics; D004435:Eating; D002149:Energy Intake; D005260:Female; D006801:Humans; D006963:Hyperphagia / Q000209:etiology*; D007421:Intestine, Small / Q000601:surgery*; D008286:Malabsorption Syndromes / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011183:Postoperative Complications; D011446:Prospective Studies
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins