title: [A case of syphilitic meningitis presenting the seventh nerve and the eighth nerve palsies].
abstract: Here we described a case of syphilitic meningitis presenting the seventh nerve and the eighth nerve palsies. A 56-year-old man was admitted because of left facial palsy and hearing loss of bilateral ears. He had a penile chancre five months before admission. Cerebrospinal fluid examination showed high pressure, pleocytosis predominantly with mononuclear cells and high protein content. STS and TPHA of serum and CSF were positive. High dose penicillin G was effective, and he was discharged with only mild hearing loss in the left. Considering the penetration of penicillin G into the CSF and the minimum fully treponemicidal concentration of penicillin, the administration of large doses of aqueous penicillin G intravenously or intramuscularly was effective in such a case to prevent permanent deafness, though CDC recommends relatively low dose.
authors.affiliation: Department of Internal Medicine, Asahi General Hospital, Chiba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Komachi
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: H
authors.initials: H
authors.lastname: Tsukagoshi
mesh_terms: D005158:Facial Paralysis / Q000209:etiology*; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D009494:Neurosyphilis / Q000150:complications* / Q000188:drug therapy; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D011379:Prognosis; D000160:Vestibulocochlear Nerve Diseases / Q000209:etiology*
chemical_list: D010400:Penicillin G