The zymodemes of Entamoeba histolytica in New Delhi, India.
The prevalence of various pathogenic and non-pathogenic zymodemes of Entamoeba histolytica in New Delhi, India was studied by characterising its isoenzyme patterns. Non-pathogenic zymodeme I was found to be most common and was detected in 39 of 49 infections. The other non-pathogenic zymodemes detected were XVII and XVIII in two cases each. The pathogenic zymodemes detected were II (four cases), II alpha- (alpha) (one case) and XIV (one case). Approximately 72% of those harbouring non-pathogenic zymodemes and 33% of those harbouring pathogenic zymodemes were asymptomatic. All the symptomatic individuals harbouring non-pathogenic zymodemes were seronegative for amoebiasis. However, subjects harbouring pathogenic zymodeme but asymptomatic were seropositive for amoebiasis at a titre of greater than 1:80, indicating a past infection or subclinical tissue invasion by the parasite. The new zymodeme isolated from a case of acute dysentery was designated II alpha- on the basis of the banding pattern of the enzyme glucose phosphate isomerase.
Baveja
U K
UK
Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
Francis
S
S
Kaur
M
M
Agarwal
S K
SK
D000562:Amebiasis / Q000201:enzymology* / Q000453:epidemiology; D000818:Animals; D004748:Entamoeba histolytica / Q000201:enzymology* / Q000472:pathogenicity; D006801:Humans; D007194:India / Q000453:epidemiology