title: [Nonproducing myeloma without evident bone lesion].
abstract: A 76-year-old female was admitted to our hospital because of anemia. Complete blood count was as follows: RBC 2.37 X 10(6)/microliters, Hb 7.7 g/dl, WBC 2,600/microliters, Plt 105 X 10(3)/microliters. A bone marrow aspirate revealed 40.8% plasmacytoid cells showing the characteristics of plasma cells by electron microscopy. Total serum protein was 5.4 g/dl. Monoclonal protein was not observed by electrophoresis. On immunoelectrophoresis, M-bow was not observed in the serum or in 50-fold concentrated urine. The plasma cells were negative for cytoplasmic IgG, M, A, E, D, kappa or lambda by immunoperoxidase studies. Although radiologic studies of the bones did not reveal destructive or punched out lesions, we diagnosed this case as a nonproducing myeloma and the patient responded to MP therapy. This case was considered interesting as regards the pathological entity of myeloma.
authors.affiliation: 2nd Department of Internal Medicine, Tottori University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kawatani
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: A
authors.initials: A
authors.lastname: Hosoda
authors.forename: H
authors.initials: H
authors.lastname: Agou
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D010950:Plasma Cells / Q000648:ultrastructure; D011239:Prednisolone / Q000008:administration & dosage
chemical_list: D011239:Prednisolone; D008558:Melphalan