title: [Drug-induced acute arterial occlusion].
abstract: An acute ischemia has almost its origin in a mechanical obstruction of the vessel caused by embolus, thrombose or dissection. An ischemia caused by medicament, excepted the erronated intraarterial injection of vasoconstrictive medicament, is very seldom encountered in the clinic. We describe the case of a young woman who was referred to our clinic for investigation and treatment of an acute ischemia of both limbs. In her past medical history she was treated because of a liver insufficiency occurring after a spontaneous abortion and received methylergometrine (Methergin) for uterine stimulation. Because of this unusual manifestation in a young patient with a complicated past medical history we considered the possibility of a drug induced ischemia caused by ergotamine-derivate. The rapid recovering after treatment with chlorpromazine and nifedipine confirmed the suspected diagnosis. A well defined therapy of this rare complication has not been described; vasodilatators, nitroglycerin, calcium-antagonists and even streptokinase and balloon dilatation are proposed.
authors.affiliation: Klinik für Thorax-, Herz- und Gefässchirurgie, Inselspital Bern.
authors.forename: T
authors.initials: T
authors.lastname: Carrel
authors.forename: B
authors.initials: B
authors.lastname: Carrel
authors.forename: H
authors.initials: H
authors.lastname: Jutzi
authors.forename: B
authors.initials: B
authors.lastname: Nachbur
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000139:chemically induced*; D007866:Leg / Q000098:blood supply*; D008111:Liver Function Tests; D008755:Methylergonovine / Q000008:administration & dosage / Q000009:adverse effects*; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy
chemical_list: D008755:Methylergonovine
vernacular_title: Occlusion artérielle aiguë d'origine médicamenteuse.