[An experimental study of the chemotherapeutic efficacy of flurenizid, a new antitubercular pharmaceutical].
The efficacy of a chemotherapeutic effect of flurenizid, a new antituberculous drug, was experimentally demonstrated. Flurenizid is an aromatic heterocyclic derivative. As estimated on the models of hematogenic disseminated and destructive pulmonary tuberculosis, a chemotherapeutic dose of the drug was 20 and 50 mg per kg body weight of an animal. Phagocytotic stimulation and fibrillogenetic intensification represent one of the mechanisms of its action. The most pronounced efficacy of flurenizid was noted when it was combined with isoniazid.
Khomenko
A G
AG
Golyshevskaia
V I
VI
Maslova
L I
LI
Kalmykova
G N
GN
Uvarova
O A
OA
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D007538:Isoniazid / Q000008:administration & dosage / Q000627:therapeutic use; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D006571:Heterocyclic Compounds; C065925:flurenizid; D007538:Isoniazid; D012293:Rifampin
Khimioterapevticheskaia éffektivnost' novogo protivotuberkuleznogo farmakologicheskogo sredstva flurenizida v éksperimente.