The effect of mycophenolic acid on the cell cycle of Candida albicans.
Mycophenolic acid inhibited the growth of Candida albicans. Cultures exposed to a concentration of 8.4 micrograms ml-1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.
Quinn
C M
CM
Biology Department, Maynooth College, Ireland.
Bugeja
V C
VC
Gallagher
J A
JA
Whittaker
P A
PA
D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D002453:Cell Cycle / Q000187:drug effects*; D015169:Colony Count, Microbial; D009173:Mycophenolic Acid / Q000494:pharmacology*
D009173:Mycophenolic Acid