[Effect of scopolia drugs on the gastric mucosal lesion in rats].
In the present paper, effects of scopolia drugs (scopolamine, anisodine, anisodamine) on experimental gastric mucosal lesion models in rats were investigated. Scopolia drugs were found to be effective anti-ulcer agents in three experimental gastric ulcer models (i.e. cold-restraint stress induced ulcer, indomethacin induced ulcer and acetic acid induced chronic ulcer) in rats in a dose dependent manner. Biochemical analysis of gastric juice and blood showed that scopolia drugs could inhibit gastric acid secretion and pepsin activity, increase gastric barrier mucus and concentration of serum gastrin, suggesting that these actions may contribute to its anti-ulcer effect.
Zhang
J F
JF
Department of Physiology, Xuzhou Medical College.
Yan
C D
CD
Zhang
Y Q
YQ
Gao
W Z
WZ
Zhai
X M
XM
D000818:Animals; D000897:Anti-Ulcer Agents; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology* / Q000627:therapeutic use; D012602:Scopolamine Derivatives / Q000494:pharmacology*; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000473:pathology*
D000897:Anti-Ulcer Agents; D012602:Scopolamine Derivatives; D012991:Solanaceous Alkaloids; C003922:anisodamine; D012601:Scopolamine; C012183:anisodine