title: Severe lidocaine intoxication by cutaneous absorption.
abstract: A severe lidocaine intoxication by cutaneous absorption is described. Data are presented to show a significant absorption of lidocaine through diseased skin when lidocaine cream is used as a local anesthetic. Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.
authors.affiliation: Department of Internal Medicine, University Hospital Leiden, The Netherlands.
authors.forename: R L
authors.initials: RL
authors.lastname: Lie
authors.forename: B J
authors.initials: BJ
authors.lastname: Vermeer
authors.forename: P M
authors.initials: PM
authors.lastname: Edelbroek
mesh_terms: D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D016410:Lymphoma, T-Cell, Cutaneous / Q000378:metabolism; D008875:Middle Aged; D009824:Ointments; D010146:Pain / Q000188:drug therapy; D012869:Skin Absorption
chemical_list: D009824:Ointments; D008012:Lidocaine