[Studies of the morphology of the thyroid gland and thyroid hormone levels in the blood of rats in experiments on "Kosmos-1667" and "Kosmos-1887"].
Using histological, electron microscopic, and biochemical (measurement of total thyroxine, free thyroxine and triiodothyronine in plasma) method, thyroid glands of 17 male rats of the Wistar SPF strain flown for 7 days on Cosmos-1667 and for 13 days on Cosmos-1887 were investigated. It was found that a longer exposure to space flight effects (for 13 days) led to a thyroid activity decline (significant reduction of thyrocyte size and nuclear area, accumulation of colloid drops in the cytoplasm, decrease of iodinated thyroglobulins in the colloid, etc.) together with a substantial decrease of T4 and T3 in plasma. The above structural and functional changes in the thyroid gland and hormonal status are characteristic of a moderate stress-reaction and reflect variations of the early and intermediate stages of adaptation to microgravity during 7- and 13-day space flights.
Plakhuta-Plakutina
G I
GI
Kabitskiĭ
E N
EN
Dmitrieva
N P
NP
Amirkhanian
E A
EA
D000337:Aerospace Medicine; D000818:Animals; D004195:Disease Models, Animal; D007037:Hypothyroidism / Q000097:blood / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013961:Thyroid Gland / Q000473:pathology* / Q000648:ultrastructure; D013963:Thyroid Hormones / Q000097:blood* / Q000172:deficiency; D013997:Time Factors; D014586:USSR; D014893:Weightlessness / Q000009:adverse effects*
D013963:Thyroid Hormones
Morfologiia shchitovidnoĭ zhelezy i soderzhanie tireoidnykh gormonov v krovi u krys v éksperimentakh na biosputnikakh "Kosmos-1667" i "Kosmos-1887".