Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine.
The authors report adverse interactions encountered when using low dose (25-75 mg) trazodone to treat insomnia associated with fluoxetine. Sixteen patients had good hypnotic responses to trazodone, but five needed to stop the medication due to excessive sedation. Three cases are described.
Metz
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A
Tufts University School of Medicine, Boston, MA.
Shader
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RI
D000328:Adult; D003863:Depression / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced / Q000188:drug therapy*; D014196:Trazodone / Q000009:adverse effects* / Q000627:therapeutic use
D005473:Fluoxetine; D014196:Trazodone