title: [Treatment of peritoneal carcinomatosis by intraperitoneal chemo-hyperthermia with mitomycin C. Initial experience].
abstract: Intra-peritoneal chemo-hyperthermia with mitomycin C was used to treat 9 patients with very advanced gastrointestinal cancers with peritoneal seedings. Resection of the primary tumor was possible in 3 cases. After temporary of closure of the abdominal wall, 90 to 120 minutes of intra-peritoneal chemo-hyperthermia was performed under general anaesthesia with 32 degrees C of systemic hypothermia, via 3 intra-peritoneal drains forming a closed circuit, using 10 mg/l of mitomycin C in 61 of peritoneal dialysate warmed at the inflow temperature of 46 to 49 degrees C. We observed no mortality or morbidity. There were only minor and temporary laboratory side effects and for 6 patients, no malignant cells could be found in the ascitic fluid after intra-peritoneal chemo-hyperthermia. In six patients, we conserved an improvement in the Karnofsky index 3 to 7 months after intra-peritoneal chemo-hyperthermia. These results show that intraperitoneal chemo-hyperthermia with mitomycin C is a safe and reliable treatment for peritoneal seedings in severely advanced gastrointestinal cancers and encourage us to proceed with this new therapeutic modality.
authors.affiliation: Service de Chirurgie Générale et Thoracique, Pierre-Bénite, France.
authors.forename: F N
authors.initials: FN
authors.lastname: Gilly
authors.forename: P Y
authors.initials: PY
authors.lastname: Carry
authors.forename: A C
authors.initials: AC
authors.lastname: Sayag
authors.forename: G B
authors.initials: GB
authors.lastname: Braillon
authors.forename: A A
authors.initials: AA
authors.lastname: Volloch
authors.forename: G G
authors.initials: GG
authors.lastname: Panteix
authors.forename: I M
authors.initials: IM
authors.lastname: James
authors.forename: P A
authors.initials: PA
authors.lastname: Chatelard
mesh_terms: D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000032:analysis / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D010976:Platelet Count
chemical_list: D001798:Blood Proteins; D008937:Mitomycins
vernacular_title: Traitement des carcinoses péritonéales par chimio-hyperthermie intra-péritonéale avec mitomycine C. Première expérience.