The role of fish oil in psoriasis. A randomized, double-blind, placebo-controlled study to evaluate the effect of fish oil and topical corticosteroid therapy in psoriasis.
In a randomized, double-blind, placebo-controlled study, patients received 10 fish or olive oil capsules three times daily for the whole study in addition to applying betamethasone diproprionate to their psoriatic plaques for the first 3 weeks. Most patients gradually worsened upon discontinuation of corticosteroids. Using survival analysis methods, no significant difference was found between the fish and olive oil groups. The authors attempt to put the role of fish oil in the therapy of psoriasis into perspective and discuss the efficacy of fish oil when used alone versus in combination therapy.
Gupta
A K
AK
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
Ellis
C N
CN
Goldfarb
M T
MT
Hamilton
T A
TA
Voorhees
J J
JJ
D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D001830:Body Surface Area; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use; D011565:Psoriasis / Q000178:diet therapy / Q000188:drug therapy*
D005395:Fish Oils; D010938:Plant Oils; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone