Activation of GD3 synthase by sex steroid hormones in cultured rat hepatocytes.
The influence of sex steroid hormones on the activities of GM3 and GD3 synthases in isolated hepatocytes was studied. Progesterone (0.1 - 2.0 microM), beta-estradiol (0.1 - 1 microM), and testosterone (0.1 - 1 microM) activate GD3 but not GM3 synthase when added directly to hepatocytes cultured in modified William's E medium.
Mesarić
M
M
Biochemical Institute, University of Freiburg, FRG.
Decker
K
K
D000818:Animals; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012799:Sialyltransferases / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D012799:Sialyltransferases; C043662:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase; C021343:haematoside synthetase; D004121:Dimethyl Sulfoxide