[Characteristics of brain gastrin/cholecystokinin-binding proteins].
Gastrin/cholecystokinin-binding proteins were purified using the column affinity chromatography on immobilized pig tetragastrin and cholecystokinin. Immunoblotting analysis of different human tissue extracts with specific antisera obtained against gastrin-binding proteins was performed. It was found that high molecular weight polypeptide zones of 120 kDa and 35 kDa were characteristic of the brain only. Autoantisera of patients with type A gastric disease reacted with some gastrin/cholecystokinin-binding proteins in human brain and mucosa including human brain polypeptide of 120 kDa. It is supposed that there are neurospecific gastrin-binding proteins (possibly gastrin/cholecystokinin receptors in the brain).
Rudenko
O A
OA
Gaĭdar
Iu A
IuA
Berezin
V A
VA
D000818:Animals; D001923:Brain Chemistry; D002846:Chromatography, Affinity; D006801:Humans; D015151:Immunoblotting; D008970:Molecular Weight; D009928:Organ Specificity; D011949:Receptors, Cholecystokinin / Q000302:isolation & purification*; D013552:Swine
D011949:Receptors, Cholecystokinin
Kharakteristika gastrin/kholetsistokininsviazyvaiushchikh belkov golovnogo mozga.