Radiation-induced graft copolymerization of methacrylic acid on to poly(vinyl chloride) films and their thrombogenicity.
Methacrylic acid (MAA) was radiation grafted on to poly(vinyl chloride) (PVC) films to improve the blood compatibility of PVC. The thromobogenicity of MAA grafted PVC was evaluated by thrombus formation, platelet adhesion and haemolytic activity in vitro. The hydrophilicity of grafted PVC films was investigated by contact angle measurement. Methacrylic acid grafted PVC film showed lower thrombogenicity than that of PVC. It was found that the weight of thrombus formed on grafted PVC was less than that of PVC and glass and decreased with the increase in the graft level. The adhesion of platelets on grafted PVC was retarded after grafting with MAA hydrogels.
Singh
J
J
Centre for Biomedical Engineering, Indian Institute of Technology, Delhi Hauz Khas New Delhi.
Ray
A R
AR
Singhal
J P
JP
Singh
H
H
D001672:Biocompatible Materials; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008689:Methacrylates; D010973:Platelet Adhesiveness / Q000502:physiology; D011108:Polymers; D011143:Polyvinyl Chloride; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology*
D001672:Biocompatible Materials; D008689:Methacrylates; D011108:Polymers; C008384:methacrylic acid; D011143:Polyvinyl Chloride