Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to beta-subunits of glycoprotein hormones.
The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type. In addition, the HUSI-II sequence shows a striking similarity to the middle part of glycoprotein hormone beta-subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal-type inhibitors and glycoprotein hormones.
Fink
E
E
Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, FRG.
Hehlein-Fink
C
C
Eulitz
M
M
D000176:Acrosin / Q000037:antagonists & inhibitors*; D000595:Amino Acid Sequence; D006023:Glycoproteins / Q000737:chemistry; D006728:Hormones / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D012661:Semen / Q000737:chemistry; D012689:Sequence Homology, Nucleic Acid; D000074162:Serine Peptidase Inhibitors, Kazal Type; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000737:chemistry*; D014361:Trypsin Inhibitors / Q000737:chemistry*
D006023:Glycoproteins; D006728:Hormones; C066238:SPINK2 protein, human; D000074162:Serine Peptidase Inhibitors, Kazal Type; D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic; D000176:Acrosin