Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.
Burk
R F
RF
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232.
Hill
K E
KE
Hunt
R W
RW
Martin
A E
AE
D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D000077604:Fomepizole; D005978:Glutathione / Q000378:metabolism; D007538:Isoniazid / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D011720:Pyrazoles; D000082:Acetaminophen; D000077604:Fomepizole; D000410:Alanine Transaminase; D005978:Glutathione; D007538:Isoniazid; D010634:Phenobarbital