Influence of gluten-derived fractions on chemiluminescence production by human neutrophils.
The effects of gliadin and glyc-gli on leukocyte chemiluminescence response were assessed in vitro. A dose-dependent increase in chemiluminescence response of neutrophils stimulated by zymosan was observed by using gliadin at concentrations ranging between 1 and 20 micrograms. By increasing glyc-gli concentration, a bimodal response was observed with an enhancement up to 50 micrograms/ml, followed by suppressive effects, which were again dose-dependent. The possible implications of these findings in human pathology are discussed.
Roccatello
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Laboratorio Nefrologia e Immunoematologia NAM, Università di Torino, Italy.
Amprimo
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MC
Coppo
R
R
Cavalli
G
G
Quattrocchio
G
G
Gianoglio
B
B
Ferrero
A
A
di Mauro
C
C
Sena
L M
LM
Piccoli
G
G
D002446:Celiac Disease / Q000209:etiology; D005609:Free Radicals; D005903:Gliadin / Q000494:pharmacology; D005922:Glomerulonephritis, IGA / Q000209:etiology; D005983:Glutens / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism
D005609:Free Radicals; C066008:glyc-gli (gluten fraction); D005983:Glutens; D005903:Gliadin; D010100:Oxygen