[A comparative study of the effects of propiverine, terodiline, oxybutynin on the lower urinary tract function in the decerebrate dog].
The effects of propiverine, terodiline, oxybutynin on the lower urinary tract function was studied by cystometry in 44 decerebrate dogs. Micturition was induced by bladder filling before and after the intravenous administration of each drug. The statistical analysis was carried out on the urodynamic parameters. Propiverine at a dose of 5, 10 mg/kg significantly increased the bladder volume. And, there was a substantial increase in the functional bladder volume at a dose of 10 mg/kg. Terodiline at a dose of 5 mg/kg also significantly increased the bladder volume and residual volume. Oxybutynin at a dose of 0.5 or 1 mg/kg produced a substantial increase in the bladder volume and residual volume, and produced a significant decrease in contraction pressure. Furthermore, there was a significant decrease in the functional bladder volume at a dose of 1 mg/kg. This study compared the three drugs under the same test conditions. Only propiverine increased the functional bladder volume, thus suggesting promise for the relief of pollakisuria in the clinical applications.
Tsuchida
S
S
Department of Urology, Akita University School of Medicine.
Nishizawa
O
O
Noto
H
H
Kaneko
S
S
D000818:Animals; D001561:Benzilates / Q000494:pharmacology*; D002082:Butylamines / Q000494:pharmacology*; D003655:Decerebrate State; D004285:Dogs; D008333:Mandelic Acids / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*; D014554:Urination / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects
D001561:Benzilates; D002082:Butylamines; D008333:Mandelic Acids; C015586:propiverine; C010637:terodiline; C005419:oxybutynin