title: Carnitine deficiency following massive intestinal resection: a morphological and biochemical study.
abstract: A 65-year-old man with progressive muscle weakness and liver dysfunction following massive small bowel resection showed myriad lipid-filled vacuoles in type I muscle fibers. Carnitine was significantly decreased in muscle, serum and urine. Carnitine supplementation was followed by clinical improvement and decreased lipid droplets in biopsied muscle. He had been receiving carnitine-deficient total parenteral nutrition. This form of carnitine deficiency may be due to a defect in carnitine biosynthesis, as well as dietary carnitine deficiency.
authors.affiliation: First Department of Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyajima
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Oikawa
authors.forename: H
authors.initials: H
authors.lastname: Honjou
authors.forename: S
authors.initials: S
authors.lastname: Kanaoka
authors.forename: N
authors.initials: N
authors.lastname: Honda
mesh_terms: D000368:Aged; D002331:Carnitine / Q000097:blood / Q000172:deficiency* / Q000652:urine; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008297:Male; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery
chemical_list: D002331:Carnitine