title: Plasma lidocaine levels and PaO2 with endobronchial administration: dilution with normal saline or distilled water?
abstract: OBJECTIVE
  To determine whether water or 0.9% saline should be used as diluent for endobronchial drug administration.
  
  
  METHODS
  Twelve adult patients.
  
  
  METHODS
  Patients were endobronchially administered 2 mg/kg lidocaine as marker substance in either 10 mL 0.9% saline or 10 mL distilled water during general anesthesia.
  
  
  RESULTS
  The differences in mean lidocaine plasma levels at five minutes (water vs saline, 2.35 vs 1.59 micrograms/mL) and ten minutes (water vs saline: 2.67 vs 1.88 micrograms/mL) were significant (P less than .05). With the initial mean PaO2 being almost (157 mm Hg; F1O2, 0.3) in the two groups, there was a mean drop of about 60 mm Hg in the saline-diluent group, but only about 40 mm Hg in the water-diluent group one minute after administration (P less than .05).
  
  
  CONCLUSIONS
  The use of water resulted in better absorption of lidocaine and less impairment of the PaO2.
authors.affiliation: Department of Anesthetics, University Hospital, Ulm, West Germany.
authors.forename: J H
authors.initials: JH
authors.lastname: Hähnel
authors.forename: K H
authors.initials: KH
authors.lastname: Lindner
authors.forename: C
authors.initials: C
authors.lastname: Schürmann
authors.forename: A
authors.initials: A
authors.lastname: Prengel
authors.forename: F W
authors.initials: FW
authors.lastname: Ahnefeld
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D007442:Intubation, Intratracheal; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D012965:Sodium Chloride / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D014867:Water; D012965:Sodium Chloride; D008012:Lidocaine; D010100:Oxygen