Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations.
A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg.
Genescà
A
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Departament de Biologia Cellular i Fisiologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Benet
J
J
Caballín
M R
MR
Miró
R
R
Germà
J R
JR
Egozcue
J
J
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002869:Chromosome Aberrations; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*
D000970:Antineoplastic Agents