[Clinical significance of DNA content of rectal cancer measured by flow cytometory].
DNA content of 369 rectal cancers was measured by flow cytometry. One hundred and four (28.2%) were diploid, 252 (68.3%) were aneuploid and 13 (3.5%) were tetraploid. Diploid cancers were associated with an improved 5 year survival (p less than 0.001) and were more likely to be diagnosed at an early stage. However DNA content did not confer independent prognostic information in a Cox model based on four discrete pathological variables. Patients were classified by a new system of prognostic grouping and those with a very good or a very poor outlook were removed leaving 137 prognostic group 3 patients. No further substratification of this group by DNA content or by four additional pathological variables could be achieved. As the new prognostic system is not improved by the additional of ploidy, routine adoption of flow cytometry in the assessment of rectal cancer can not be recommended.
Mukawa
K
K
Department of Surgery, Gunma Prefectural Maebashi Hospital, Maebashi, Japan.
D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011123:Polyploidy; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology; D012044:Regression Analysis
D004273:DNA, Neoplasm