Self-splicing group II and nuclear pre-mRNA introns: how similar are they?
The splicing pathway of pre-mRNA introns bears similarities to that of the group II introns, some members of which undergo self-splicing. The snRNAs may provide the pre-mRNA introns with RNA structures in trans comparable to those available in cis in group II introns. This article examines the available evidence for the hypothesis that the catalysis of these two splicing pathways is fundamentally equivalent.
Jacquier
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Département de Biologie, Moléculaire, Institut Pasteur, Paris, France.
D000818:Animals; D001483:Base Sequence; D006801:Humans; D007438:Introns / Q000502:physiology*; D008969:Molecular Sequence Data; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing / Q000502:physiology*; D015138:RNA, Nuclear / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics
D012322:RNA Precursors; D015138:RNA, Nuclear