Competing antagonists to energy production in space and their effect on calcium metabolism.
In microgravity, energy demand and its production are impressively decreased resulting in the clinical consequences of negative calcium balance and inhibited biosynthesis. Increased concentration of the underutilized ATP inhibits phosphorylation and decarboxylation resulting in increased tricarboxylates. Citrates mobilize calcium resulting in diseases mediated by the withdrawal of the citrate complexed calcium from hard and soft tissues. If man is to live in space for extended periods of time, he must dramatically reduce antagonists to energy production and substitute measures that enhance metabolic respiration.
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D000222:Adaptation, Physiological; D002118:Calcium / Q000378:metabolism*; D002951:Citrates / Q000008:administration & dosage; D004032:Diet; D004734:Energy Metabolism / Q000187:drug effects; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D013026:Space Flight; D014893:Weightlessness
D002951:Citrates; D002118:Calcium