Dipalmitoylphosphatidylcholine (L-alpha-lecithin) stimulates prostaglandin E production in human amnion.
The effect of dipalmitoylphosphatidylcholine (DPPC, L-alpha-lecithin), a substance not containing arachidonic acid, on prostaglandin E (PGE) production of amniotic membrane was studied. DPPC (3.125-800 micrograms/ml) stimulated PGE production of amniotic membrane (150-200%), suggesting that lecithin, the major surfactant component, is directly involved in the mechanism of human parturition as a stimulator of PGE production.
Ohtsuka
T
T
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
Lee
H C
HC
Yamaguchi
M
M
Mori
N
N
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000494:pharmacology*; D000650:Amnion / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis*; D013268:Stimulation, Chemical
D011458:Prostaglandins E; D015060:1,2-Dipalmitoylphosphatidylcholine