[Contractile properties of coronary artery bypass conduit--comparison between saphenous vein and internal mammary artery].
This study was designed to examine the response of coronary artery bypass conduit to serotonin, phenylephrine, and ergonovine as provocation agents of vasoconstriction. Saphenous veins (SV) and internal mammary arteries (IMA) were obtained during coronary artery bypass grafting (CABG), and their contractile properties were measured using isometric contraction recording apparatus. Both SV and IMA showed sigmoid contraction curves indicating dose dependence to ergonovine, serotonin, and phenylephrine. The concentration-response relations for phenylephrine showed a similar curve in both SV and IMA, however, those for ergonovine and serotonin showed a leftward shift in SV compared with IMA. Half maximum effective dose for ergonovine and serotonin were less in SV than IMA. From these results, it was suggested that "perioperative spasm" during CABG might occur not only in coronary arteries but also in the graft conduit itself. Graft spasm might be a possible mechanism for occlusion of the bypass graft. In conclusion, greater hyperreactivity of SV compared with IMA in response to ergonovine and serotonin was suggested, so it is concluded that, from this point of view, IMA is more suitable for use in CABG.
Koike
R
R
Department of Thoracic Surgery, Osaka Medical College.
Suma
H
H
Kondoh
K
K
Satoh
H
H
Oku
T
T
Sawada
Y
Y
Takeuchi
A
A
Hirata
K
K
Awano
K
K
Yokoyama
M
M
D001026:Coronary Artery Bypass; D004874:Ergonovine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008323:Mammary Arteries / Q000502:physiology* / Q000637:transplantation; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D012501:Saphenous Vein / Q000502:physiology* / Q000637:transplantation; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D010656:Phenylephrine; D012701:Serotonin; D004874:Ergonovine