Modifications of biological activities of heparin and fraxiparine induced by the size and the age of a thrombus. Experimental study.
Heparin and its fractions have often been tested on fresh experimental thrombosis. However in human clinic, drugs are administered not on fresh, but rather on old constituted thrombi. In order to evaluate the effects of antithrombotic agents in these conditions, both drugs (unfractionated heparin and Fraxiparine) were administered on 150 rats at different times and so, could take effect on thrombi with different ages. Heparin was more active as its fraction on fresh thrombi (2 hours old), but no more effects could be observed for all drugs when the thrombus was 52 hours old. Biological activities (A.P.T.T., anti-IIa and anti-Xa activities) decreased as the thrombi increased in weight and age.
Doutremepuich
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Laboratoire d'Hématologie, C.J.F. INSERM 88/13, Bordeaux, France.
Llido
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Lalanne
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MC
Doutremepuich
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F
D000818:Animals; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D065427:Factor Xa Inhibitors; D011516:Prothrombin; C025337:Factor IIa; D006493:Heparin