[Effects of dopamine on stress ulcer].
Preventive effect of dopamine on stress ulcer formation was investigated in rats. Dopamine 1-10 micrograms/kg/min suppressed the elevation of ulcer index significantly after water immersion and restraint stress in a dose-dependent fashion, however ulcer indices of 25 micrograms/kg/min of dopamine were higher than 10 micrograms/kg/min. Dopamine 1-10 micrograms/kg/min suppressed the decrease of gastric mucosal blood flow, gastric mucosal prostaglandin E2 content and gastric transmucosal potential difference during stress loading in a dose-dependent manner, although the suppression of them in 25 micrograms/kg/min of dopamine was smaller than in 10 micrograms/kg/min also. Dopamine suppressed the increase of gastric acid secretion and gastric motility during stress loading in a dose-dependent fashion up to 25 micrograms/kg/min. These results indicates that dopamine suppresses the formation of stress ulcer by increasing defensive factors and decreasing aggressive factors.
Nagahata
Y
Y
First Department of Surgery, Kobe University School of Medicine.
Urakawa
T
T
Moritomo
H
H
Ichihara
T
T
Itoh
A
A
Takeda
K
K
Kuroda
H
H
Idei
H
H
Tomonaga
K
K
Saitoh
Y
Y
D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007101:Immersion / Q000009:adverse effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy*; D013312:Stress, Physiological; D014867:Water
D014867:Water; D015232:Dinoprostone; D004298:Dopamine