[Platelet-activating factor in Japanese cedar pollinosis].
Japanese cedar pollinosis is a typical allergic disease and has recently become a big social problem. Many population are suffering from this disease every year from the end of February to the beginning of April. In this study, we planned to examine the role of platelet-activating factor (PAF) in this disease, because PAF has been known to be one of the potent chemical mediators in allergic and inflammatory reactions and many evidences indicate that PAF is deeply involved in the pathogenesis of bronchial asthma, a typical allergic disease. We measured the concentrations of the PAF derivative (lyso-PAF) in serum from patients with cedar pollinosis during the pollen season. The level of lyso-PAF in serum from untreated patients with cedar pollinosis (87.8 +/- 8.7 unit.) was significantly higher than that in healthy control (54.9 +/- 7.7 unit.). We also tested the effect of an anti-allergic drug on the level of serum lyso-PAF of cedar pollinosis. Eighteen pairs of serum samples from patients with cedar pollinosis were employed in this study. Lyso-PAF levels after two weeks' therapy with ketotifen (2 mg/day), an anti-allergic drug, decreased the levels significantly (from 82.6 unit to 41.3 unit). These results suggest that PAF could play some important role in cedar pollinosis and that the clinical effect of anti-allergic drug could be partially due to the anti-PAF action.
Nakamura
T
T
Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo.
Ishihara
K
K
Kuriyama
M
M
Miyamoto
T
T
Matsumura
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000378:metabolism; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000188:drug therapy; D014197:Trees
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D007665:Ketotifen