title: The influence of penbutolol and placebo on blood sugar levels and insulin consumption in the glucose-controlled insulin infusion system ("artificial endocrine pancreas").
abstract: The aim of the study was to investigate the influence of 40 mg of the beta-blocker penbutolol (Betapressin TM; Hoechst Ltd., Frankfurt/Main) in comparison to placebo on the insulin consumption on the blood sugar profile in twelve insulin-dependent diabetes (IDDM) patients. The patients were treated with penbutolol and placebo for a period of three days, and then were examined with the help of the glucose-controlled insulin infusion system. The blood sugar profile and insulin consumption over a 24 hour period was not affected by either penbutolol or placebo, nor could any changes be measured in these parameters when measured after food intake. After a submaximal exercise load on the bicycle ergometer (1 watt per kg body weight) following an evening meal, no difference could be observed between penbutolol and placebo in the above-mentioned parameters. The same was also true for hormonal parameters as STH, ACTH, cortisol, and catecholamines. These findings demonstrated that medication of penbutolol over a three-day period has no influence on the baseline blood sugar profile and insulin consumption or on insulin consumption after food intake during rest and physical exercise.
authors.affiliation: III. Medizinische Klinik und Poliklinik, Innere Medizin und Endokrinologie, Johannes Gutenberg-Universität Mainz.
authors.forename: T
authors.initials: T
authors.lastname: Weber
authors.forename: G
authors.initials: G
authors.lastname: Schulz
authors.forename: J
authors.initials: J
authors.lastname: Beyer
authors.forename: H
authors.initials: H
authors.lastname: Geiling
authors.forename: U
authors.initials: U
authors.lastname: Cordes
authors.forename: C
authors.initials: C
authors.lastname: Diederich
authors.forename: U
authors.initials: U
authors.lastname: Krause
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007332:Insulin Infusion Systems; D008297:Male; D010394:Penbutolol / Q000494:pharmacology*; D010919:Placebos
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D006728:Hormones; D007328:Insulin; D010919:Placebos; D010394:Penbutolol