title: [Ectericide as a dispersion medium for the preparation of prospective clinical liposomal drug forms].
abstract: The possibility of using ectericide, having antibacterial, detergent, antioxidative, and reparative effects, as a dispersion medium for liposome production has been studied. Its application allows for elaboration of a simplified liposome production technique simultaneously imparting them stability against oxidation, heating, and pH changes. A technology to produce multivesicular liposomes with ectericide++, containing rifampicin in the membranous envelope and gentamicin in the inner volume, has been developed. Liposomal antibiotics proved to be effective in clinical trials.
authors.forename: I L
authors.initials: IL
authors.lastname: Dikiĭ
authors.forename: L S
authors.initials: LS
authors.lastname: Strel'nikov
authors.forename: V I
authors.initials: VI
authors.lastname: Chueshov
authors.forename: V D
authors.initials: VD
authors.lastname: Iakovenko
authors.forename: A D
authors.initials: AD
authors.lastname: Bazavluk
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D008081:Liposomes / Q000138:chemical synthesis* / Q000627:therapeutic use; D013678:Technology, Pharmaceutical / Q000379:methods*; D014020:Tissue Extracts
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004337:Drug Carriers; D008081:Liposomes; D014020:Tissue Extracts; C014523:ectericide
vernacular_title: Ekteritsid kak dispersionnaia sreda dlia polucheniia klinicheski perspektivnykh liposomal'nykh lekarstvennykh form.