title: Delayed endolymphatic hydrops and its relationship to Meniére's disease.
abstract: Delayed endolymphatic hydrops (EH) can be characterized as having ipsilateral and contralateral types. They are similar in that both have early and late phases of otologic symptoms and that the early phase is a profound hearing loss in one ear. The late phases differ, however, in that the ipsilateral type develops the symptoms of EH (episodic vertigo) in the deaf ear and the contralateral type develops the symptoms of EH (fluctuating hearing loss and/or episodic vertigo) in the hearing ear. In more than half the cases of both types of delayed EH, the profound hearing losses in the early phase are simply discovered to be present in early childhood without a known time of onset. The temporal bones of two patients with contralateral delayed EH show pathologic changes in the deaf ears that are similar to those known to occur in mumps and measles labyrinthitis, whereas the pathologic changes in the hearing ears are similar to those known to occur in Meniere's disease. These observations support the proposition that Meniere's disease may occur as a delayed sequela of inner ear damage sustained during an attack of subclinical viral labyrinthitis occurring in childhood.
authors.affiliation: Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
authors.forename: H F
authors.initials: HF
authors.lastname: Schuknecht
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuka
authors.forename: C
authors.initials: C
authors.lastname: Zimmermann
mesh_terms: D000293:Adolescent; D000328:Adult; D001284:Atrophy / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003053:Cochlear Duct / Q000473:pathology; D004487:Edema / Q000150:complications* / Q000473:pathology; D004711:Endolymphatic Duct / Q000473:pathology; D006801:Humans; D007762:Labyrinthitis / Q000150:complications; D008575:Meniere Disease / Q000209:etiology*; D008875:Middle Aged; D013701:Temporal Bone / Q000473:pathology; D014777:Virus Diseases / Q000150:complications