title: [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
abstract: Authors examined the effect of D-penicillamin (Pw) on liver cirrhosis induced by chronic CCl4 and phenobarbital (Pb) treatment in Fischer 344 rats. Morphometric analysis of quantity of connective tissue fibres did not show decrease on the effect of Pe treatment. Quantity of hydroxiproline, which is one of the parameters of coll ahen decrease, did not change significantly on effect of drug, but only compared to CCl4 and Pb treated control. Quantity of glycosaminoglycan showed increase following Pe treatment. Lymphocyte stimulation by Con-A was different in CCl4 and Pb and Pe treated groups, respectively. According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful. It seems that Pe is effective only in forms of cirrhosis accompanied by significant copper accumulation, by decrease of toxic effects of copper.
authors.affiliation: Semmelweis Orvostudományi Egyetem I. sz. Pathologiai.
authors.forename: Z
authors.initials: Z
authors.lastname: Schaff
authors.forename: K
authors.initials: K
authors.lastname: Lapis
authors.forename: B
authors.initials: B
authors.lastname: Szende
authors.forename: A
authors.initials: A
authors.lastname: Jeney
authors.forename: R
authors.initials: R
authors.lastname: Gonzales Cabello
authors.forename: P
authors.initials: P
authors.lastname: Gergely
authors.forename: K
authors.initials: K
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: Divald
authors.forename: F
authors.initials: F
authors.lastname: Timár
authors.forename: J
authors.initials: J
authors.lastname: Major
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology / Q000517:prevention & control*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats
chemical_list: D002251:Carbon Tetrachloride; D010396:Penicillamine
vernacular_title: A D-penicillamin hatása a CCl4 kiváltotta kísérletes májcirrhosisra.