Preincubation with intravenous lipid emulsion reduces chemotactic motility of neutrophils in cord blood.
Neutrophils from cord blood of healthy term infants were isolated and incubated for 30 min with varying concentrations of intravenous lipid emulsion (ILE) solution (4, 8, 20 mg/ml). In vitro assay of chemotaxis was performed after incubation for 120 min with endotoxin-activated serum (EAS). Neutrophil random motility was unchanged after ILE incubation yet chemotactic factor (EAS)-stimulated motility was significantly reduced in a dose-related pattern.
Kohelet
D
D
Department of Neonatology, Assaf Harofeh Medical Center, Zerifin, Israel.
Peller
S
S
Arbel
E
E
Goldberg
M
M
D002465:Cell Movement / Q000187:drug effects* / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology
D005217:Fat Emulsions, Intravenous