Influence of high-energy shock waves and cisplatin on antitumor effect in murine bladder cancer.
The potential application of high-energy shock waves (HESW) for control of experimental bladder cancer was investigated. Subcutaneous 3-d murine bladder cancer (MBT-2) in C3H mice were exposed to HESW alone (250 to 1,500 shocks) or in combination with cisplatin (5 to 10 mg/kg, i.p.). Although HESW alone showed no influence on tumor growth, HESW/cisplatin combination therapy suppressed tumor growth more than cisplatin alone. Subsequent studies revealed that an air-fluid interface relative to tumor location played a pivotal role for the chemosensitizing effect of HESW. HESW treatment was able to enhance the cisplatin cytotoxicity only when the tumors were placed adjacent to the air-fluid interface.
Lee
K E
KE
Department of Urology, University of Rochester, School of Medicine, New York.
Smith
P
P
Cockett
A T
AT
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D008096:Lithotripsy; D051379:Mice; D008809:Mice, Inbred C3H; D014410:Tumor Stem Cell Assay; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D002945:Cisplatin