title: Central changes in hypothyroid myopathy: a case report.
abstract: A muscle biopsy from a patient with hypothyroid myopathy showed striking central changes. "Cores" were seen in most type 1 fibers with oxidative enzyme preparations. Electron microscopy of these areas revealed Z disc streaming, myofilament disruption, and absent mitochondria. The myopathy rapidly improved with thyroxine treatment. This biopsy is of interest, as numerous "cores" have not previously been reported in hypothyroid myopathy.
authors.affiliation: Neurology Service, Veterans Administration Medical Center, Kansas City, MO 64128.
authors.forename: R M
authors.initials: RM
authors.lastname: Evans
authors.forename: I
authors.initials: I
authors.lastname: Watanabe
authors.forename: P A
authors.initials: PA
authors.lastname: Singer
mesh_terms: D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology / Q000473:pathology*; D009135:Muscular Diseases / Q000201:enzymology / Q000209:etiology / Q000473:pathology*