title: The HSP70 multigene family of Caenorhabditis elegans.
abstract: 1. The heat shock response of the nematode Caenorhabditis elegans has been characterized. 2. There are at least nine genes in the hsp70 multigene family of C. elegans. 3. Five of the hsp70 genes have been characterized and assigned to one of at least three hsp70 gene subfamilies. One of the subfamilies consists of an hsp70 protein that has the potential to be translocated into the endoplasmic reticulum and another subfamily consists of a protein that has the potential to be translocated into the mitochondria. 4. The C. elegans hsp70 multigene family has several unique characteristics including introns in the heat inducible hsp70 genes, at least one trans-spliced hsp70 mRNA and two grp78 related genes, one of which is highly heat inducible. 5. The identification and characterization of C. elegans hsp70 multigene family is the basis for a genetic characterization of the regulation and function of a gene family during the development of a multicellular eukaryote.
authors.affiliation: Department of Physiological Chemistry, University of Wisconsin-Madison 53706.
authors.forename: M F
authors.initials: MF
authors.lastname: Heschl
authors.forename: D L
authors.initials: DL
authors.lastname: Baillie
mesh_terms: D000818:Animals; D002107:Caenorhabditis / Q000235:genetics*; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000235:genetics*; D006358:Hot Temperature; D005810:Multigene Family; D012326:RNA Splicing
chemical_list: D006360:Heat-Shock Proteins