Nitrendipine therapy in asthmatic subjects.
Nitrendipine was given to eight patients with chronic stable asthma prior to a histamine challenge study and compared in a double-blind cross-over fashion with placebo. There were no significant differences in either the bronchoconstrictor effects of histamine, or in oxygen saturation during the histamine challenges, suggesting that nitrendipine should be safely tolerated if used to treat hypertension in patients with airflow obstruction.
Mulloy
E M
EM
Ham Green Hospital, Pill, Bristol.
Cormie
P
P
Harvey
J
J
Marley
J E
JE
D000328:Adult; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008448:Maximal Expiratory Flow Rate / Q000187:drug effects; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use*; D010100:Oxygen / Q000378:metabolism
D006632:Histamine; D009568:Nitrendipine; D010100:Oxygen