title: Quantitative detection of brain aberrations in human immunodeficiency virus type 1-infected individuals by magnetic resonance imaging.
abstract: The brains of 65 individuals with antibodies to human immunodeficiency virus type 1 (HIV-1), 20 HIV-1 seronegative homosexual men, and 75 heterosexual controls were examined by a quantitative magnetic resonance imaging technique. A white matter aberration was detected most frequently in patients with AIDS-related complex (ARC) or AIDS, but also in asymptomatic HIV-1 seropositive persons and in HIV-1 seronegative homosexual men, of whom two of three tested were reactive for HIV-1 DNA by polymerase chain reaction. The aberration was not found in the control group. Brain atrophy was mainly confined to patients with ARC or AIDS. The brain lesions correlated with the presence of HIV-1 in cerebrospinal fluid and with elevated levels of beta 2-microglobulin and neopterin. The most pronounced brain aberrations were in patients with AIDS-dementia complex. These findings indicate that brain aberrations may occur in persons in the early stages of HIV-1 infection, although to no greater extent than in HIV-1 seronegative homosexual men. The occurrence of pronounced brain lesions seems to be associated with the presence of an advanced immunodeficiency.
authors.affiliation: Department of Infectious Diseases, Roslagstull Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sönnerborg
authors.forename: J
authors.initials: J
authors.lastname: Sääf
authors.forename: B
authors.initials: B
authors.lastname: Alexius
authors.forename: O
authors.initials: O
authors.lastname: Strannegård
authors.forename: L O
authors.initials: LO
authors.lastname: Wahlund
authors.forename: L
authors.initials: L
authors.lastname: Wetterberg
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid / Q000473:pathology; D000386:AIDS-Related Complex / Q000134:cerebrospinal fluid / Q000473:pathology; D000328:Adult; D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D001921:Brain / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000473:pathology*; D006679:HIV Seropositivity / Q000134:cerebrospinal fluid / Q000473:pathology; D015497:HIV-1 / Q000302:isolation & purification; D006716:Homosexuality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001613:beta 2-Microglobulin; D001708:Biopterins; D019798:Neopterin