Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro.
Myelin phagocytosis in Wallerian degeneration of peripheral nerves depends on invasion of nerves by non-resident macrophages. The present study was done to clarify the role of the macrophage complement receptor type 3 (CR3) in myelin removal. Myelin phagocytic capacity of invading macrophages was abolished by treatment of cultured nerves and macrophages with anti-CR3 antibody or by serum complement depletion with cobra venom factor. This indicates that myelin phagocytosis is mediated by the macrophage CR3.
Brück
W
W
Abteilung für Neuropathologie, Universität Göttingen, Federal Republic of Germany.
Friede
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RL
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D016177:Macrophage-1 Antigen / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000276:immunology / Q000648:ultrastructure*; D010525:Peripheral Nerves / Q000648:ultrastructure; D010587:Phagocytosis
D016177:Macrophage-1 Antigen