Distribution of liposomes in tuberculous mice.
The dynamics of the distribution of liposomes for use as drug carriers for the treatment of tuberculosis is studied. While the free radiolabel injected into mice was rapidly excreted by the kidneys, the same label trapped within liposomes was retained for longer periods in the liver, spleen and lung. There were variations in the distribution and retention times of liposomes of different composition. When the distribution of liposomes in healthy and tuberculous mice was compared, a greater accumulation in the liver, spleen and lungs of healthy mice was observed, although the retention time in tuberculous mice was longer. These findings merit consideration in the design of therapies based on liposome-entrapped drugs as the dynamics of distribution and retention differ between normal and infected animals.
Orozco
L C
LC
Group of Mycobacteria, Instituto Nacional de Salud, Bogota, Columbia.
Forero
M
M
Wasserman
M
M
Ahumada
J J
JJ
D000818:Animals; D004337:Drug Carriers; D007668:Kidney / Q000378:metabolism; D008081:Liposomes / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D013154:Spleen / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives; D014376:Tuberculosis / Q000378:metabolism*
D004337:Drug Carriers; D008081:Liposomes; C034230:technetium Tc 99m-Sn-DTPA; D016284:Technetium Tc 99m Pentetate