Carnitine deficiency following massive intestinal resection: a morphological and biochemical study.
A 65-year-old man with progressive muscle weakness and liver dysfunction following massive small bowel resection showed myriad lipid-filled vacuoles in type I muscle fibers. Carnitine was significantly decreased in muscle, serum and urine. Carnitine supplementation was followed by clinical improvement and decreased lipid droplets in biopsied muscle. He had been receiving carnitine-deficient total parenteral nutrition. This form of carnitine deficiency may be due to a defect in carnitine biosynthesis, as well as dietary carnitine deficiency.
Miyajima
H
H
First Department of Medicine, Hamamatsu University School of Medicine, Japan.
Sakamoto
M
M
Oikawa
T
T
Honjou
H
H
Kanaoka
S
S
Honda
N
N
D000368:Aged; D002331:Carnitine / Q000097:blood / Q000172:deficiency* / Q000652:urine; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008297:Male; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery
D002331:Carnitine