[The effect on gastric secretion and the anti-ulcer action of imidazo[1,2-A]benzimidazole derivatives].
The experiments on rats showed that of 16 studied imidazo [1,2-a]benzimidazole derivatives only the compounds with phenyl at the second carbon atom and nitrogen-containing radical of the ninth nitrogen atom inhibit the gastric acid secretion. The binding of oxymethyl group to phenyl, its substitution through adamantyl, displacement of nitrogen-containing substitute to the first nitrogen atom or its substitution were found to decrease or stop the inhibiting action of these substances on the gastric parietal cells. Dihydrochloride 2-phenyl-9 (beta-diethyl-aminoethyl)imidazo [1,2-a]denzimidazole was more potent than cimetidine and omeprazole in inhibiting the gastric acid secretion, pepsin output and antiulcer action.
Spasov
A A
AA
Kovalev
G V
GV
Bakumov
P A
PA
Reshetov
M E
ME
Anisimova
V A
VA
Avdiunina
N I
NI
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000897:Anti-Ulcer Agents; D007093:Imidazoles
Vliianie na zheludochnuiu sekretsiiu i protivoiazvennoe deĭstvie proizvodnykh imidazo[1,2-A]benzimidazola.