[A mixed infection of lymphoid cell lines by the human T-lymphotropic retrovirus type I (HTLV-I) and the measles vaccine virus].
Interaction of HTLV-1 and vaccine strain of measles virus (VM-L16) in different T and B cell lines was studied. VM-L16 replicated in T and B cells with a cytopathic effect. At a multiplicity of infection of 1 TCD50 per 10 cells, all the cells in cultures died within 4-13 days. No effect of HTLV-1 on cell sensitivity to VM-L16 was demonstrated. HTLV-1 produced in various T-cell lines had different syncytium-forming activity in XC cell cultures. Cocultivation of C91/pL cells with XC cells led to the formation of multiple syncytia. HUT-102 cells had no such activity. Infection of these cell lines with VM-L16 did not change their properties. Another HTLV-1-infected cell line, MT-2, caused insignificant aggregation of XC cells. Infection of the latter with VM-L16 increased the number of racemations 8-fold, and they consisted of numerous adhesive cells. The cell adhesion, however, which is the first stage of syncytium formation did nor terminate in cytoplasm confluence. MT-2 nad XC cell lines may be used as model systems for the study of various factors influencing HTLV-1 activation.
Iakovleva
L S
LS
Bogomolova
N N
NN
D001402:B-Lymphocytes / Q000382:microbiology*; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured / Q000382:microbiology; D003588:Cytopathogenic Effect, Viral; D015490:HTLV-I Infections / Q000382:microbiology*; D015368:Human T-lymphotropic virus 1 / Q000254:growth & development; D006801:Humans; D008457:Measles / Q000382:microbiology*; D008458:Measles Vaccine; D008459:Measles virus / Q000254:growth & development; D013601:T-Lymphocytes / Q000382:microbiology*; D013997:Time Factors; D014775:Virus Activation; D014779:Virus Replication
D008458:Measles Vaccine
Smeshannaia infektsiia limfoidnykh kletochnykh liniĭ T-limfotropnym retrovirusom cheloveka I tipa (HTLV-I) i vaktsinnym virusom kori.