title: Effect of small bowel resection on fecal bile acid excretion and on experimental colon tumour in rats.
abstract: Ileal and jejunal resections were carried out to investigate their effect on the faecal bile acid excretion and on the development of 1,2-dimethylhydrazine (DMH)-induced colonic cancer in rats. Both resection types raise the total daily faecal bile acid level compared to the control sham-operated group, whereas ileal resection has a more pronounced effect. The incidence of tumours was found higher in groups with enhanced faecal bile acid level. Our findings show a connection between the daily faecal bile acid excretion and the incidence of DMH-induced colonic cancer.
authors.affiliation: 2nd Department of Surgery, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: K
authors.initials: K
authors.lastname: Morvay
authors.forename: K
authors.initials: K
authors.lastname: Szentléleki
authors.forename: G
authors.initials: G
authors.lastname: Török
authors.forename: A
authors.initials: A
authors.lastname: Pintér
mesh_terms: D019813:1,2-Dimethylhydrazine; D000714:Anastomosis, Surgical; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism* / Q000502:physiology; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000503:physiopathology*; D004127:Dimethylhydrazines; D005243:Feces / Q000737:chemistry*; D007082:Ileum / Q000601:surgery; D007421:Intestine, Small / Q000601:surgery*; D007583:Jejunum / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001647:Bile Acids and Salts; D002273:Carcinogens; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine