[Cerebrospinal fluid transfer of cefbuperazone in the blood-brain barrier lesions of neurosurgical patients].
Cefbuperazone (CBPZ) was given in 15 patients after surgery. There was no infections except for 1 case in which signs of infections were suspected. As side effects, slight elevations in hepatic transaminase levels were observed in 3 patients during the CBPZ chemotherapy. CBPZ concentrations in 7 patients were studied. The subjects were divided into 3 groups according to CT finding during the chemotherapy to correlate CBPZ concentrations to degrees of blood-brain barrier lesions; Group I: no enhancement, Group II: mild or focal enhancement, Group III: diffuse and marked enhancement. It was interesting to note that the more marked enhancement were obtained, the higher levels of CSF concentration of CBPZ.
Nakata
M
M
Department of Neurosurgery, University of The Ryukyus.
Mukawa
J
J
Miyagi
K
K
Kinjou
T
T
Sakuta
O
O
Miyazato
H
H
Okuyama
K
K
Higa
Y
Y
Terada
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D001812:Blood-Brain Barrier; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000601:surgery; D002513:Cephamycins / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication
D002513:Cephamycins; C035978:cefbuperazone