Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P less than 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).
Smith
K R
KR
Department of Medicine, University of Alabama, Birmingham School of Medicine 35294.
Lank
K M
KM
Cobbs
C G
CG
Cloud
G A
GA
Dismukes
W E
WE
D000666:Amphotericin B / Q000097:blood / Q000627:therapeutic use*; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy*; D054714:Echinocandins; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D010455:Peptides / Q000097:blood / Q000627:therapeutic use; D010456:Peptides, Cyclic
D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; C042101:cilofungin