[Role of stromal microenvironment in the regulation of bone marrow hemopoiesis after curantyl administration].
Role of the stromal microenvironment in regulation of bone marrow hemopoiesis at the administration of the thrombocyte disaggregant curantyl was studied by the method of heterotopic transplantation of the mice bone marrow. It is shown that the action of curantyl on hemopoiesis is realised through the stem stromal cells of the bone marrow. It is noted that the inhibitory action of the preparation on proliferation of osteogenic precursor-cells is followed by activation of bone resorption processes in regenerating ectopic hemopoietic organ. Under the action of curantyl at low bone marrow cellularity in the focus of heterotopic hemopoiesis and femur an increase of mitotic activity in hemopoietic elements is noted. It is revealed that a phenomenon of ineffective megakaryocytopoiesis with intramedullary destruction of megakaryocytes leads to the local excretion of the thrombocyte released growth factor (TRGF) which has a compensatory character.
Ivasenko
I N
IN
Klestova
O V
OV
Arkad'eva
G E
GE
Almazov
V A
VA
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004176:Dipyridamole / Q000494:pharmacology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D008533:Megakaryocytes; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010982:Platelet-Derived Growth Factor / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D004176:Dipyridamole
Izuchenie roli stromal'nogo mikrookruzheniia v reguliatsii kostnomozgovogo gemopoéza pri vvedenii kurantila.