Hypoxic-ischemic damage and the neuroprotective effects of GM1 ganglioside.
In vitro studies have shown that monosialoganglioside GM1 reduces excitatory amino acid-related neurotoxicity by limiting the downstream consequences of abusive excitatory amino acid receptor stimulation. Systemic administration of GM1 appears to be efficacious in reducing acute neuronal damage and in facilitating medium- and long-term functional recovery after brain injury. We propose that GM1 protective effects in the acute injury phase results from attenuation of excitotoxicity, whereas the functional recovery seen at longer term could reflect GM1 potentiation of neuronotrophic factors. The potential therapeutic efficacy of GM1 administration in humans is suggested by clinical studies demonstrating improved neurologic outcome in stroke patients.
Leon
A
A
Fidia Research Laboratories, Abano Terme, Italy.
Lipartiti
M
M
Seren
M S
MS
Lazzaro
A
A
Mazzari
S
S
Koga
T
T
Toffano
G
G
Skaper
S D
SD
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002545:Brain Ischemia / Q000378:metabolism*; D002490:Central Nervous System / Q000503:physiopathology; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D002534:Hypoxia, Brain / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism
D000596:Amino Acids; D005677:G(M1) Ganglioside