title: A study of non-toxic goitre.
abstract: A population study showed a prevalence of 2.8% for nontoxic goitres. The clinical significance of non-toxic goitres were not previously defined. This study examined 64 patients with non-toxic goitres which were classified clinically as diffuse (gp1), lobular (gp2) and nodular (gp3). They were studied in terms of thyroid antibodies, radioisotope scanning, ultrasonography and fine-needle aspiration cytology. The goitres were mainly nodular (69%), the rest were diffuse and lobular in equal numbers. Seventy percent of the nodular goitres had 1 nodule. One case of diffuse goitre and half the lobular goitres had multinodularity demonstrated on imaging. Antithyroid antibodies were detected in 20% of gp2, 7% of gp3 and none in gp1. Malignancy was found in 2% of gp2, 11% of gp3 and nil in gp1. A management strategy for non-toxic goitre was discussed.
authors.affiliation: Department of Medicine I, Singapore General Hospital.
authors.forename: K W
authors.initials: KW
authors.lastname: Wang
authors.forename: C F
authors.initials: CF
authors.lastname: Sum
authors.forename: K T
authors.initials: KT
authors.lastname: Tan
authors.forename: W Y
authors.initials: WY
authors.lastname: Ng
authors.forename: J S
authors.initials: JS
authors.lastname: Cheah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002648:Child; D005260:Female; D006042:Goiter / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D006044:Goiter, Nodular / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence