Chronic stress and memory: implication of the central cholinergic system.
Restraint stress for ten days (two times two hours daily) induces a hypersensitivity of the central cholinergic system, reflected by antagonism to amnesia induced by scopolamine at 0.1 mg/kg in a passive avoidance test and by hypersensitivity to the hypothermic effect of oxotremorine at 1 mg/kg. A restraint stress for 30 days, on the other hand, diminishes animal retention in the passive avoidance test and causes a hyposensitivity to oxotremorine-induced hypothermia, reflecting a hypoactivity of the central cholinergic system. An acute 24-hour stress causes no change. The relationship between chronic stress and associated memory deficits is discussed.
Zerbib
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Laboratoire d'Eutonologie, Hôpital Boucicaut, Paris, France.
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D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D002908:Chronic Disease; D004597:Electroshock; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010095:Oxotremorine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology*
D010095:Oxotremorine; D012601:Scopolamine