title: Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin.
abstract: Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.
authors.affiliation: Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Naparstek
authors.forename: A
authors.initials: A
authors.lastname: Ben-Yehuda
authors.forename: M P
authors.initials: MP
authors.lastname: Madaio
authors.forename: R
authors.initials: R
authors.lastname: Bar-Tana
authors.forename: L
authors.initials: L
authors.lastname: Schuger
authors.forename: G
authors.initials: G
authors.lastname: Pizov
authors.forename: Z V
authors.initials: ZV
authors.lastname: Neeman
authors.forename: I R
authors.initials: IR
authors.lastname: Cohen
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D003429:Cross Reactions / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control*; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008181:Lupus Nephritis / Q000235:genetics / Q000517:prevention & control; D051379:Mice; D009394:Nephritis, Hereditary / Q000235:genetics / Q000517:prevention & control
chemical_list: D000974:Antibodies, Antinuclear; D006493:Heparin