[Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A].
The influence was studied of the type of immunosuppression on calciuria, phosphaturia, and on the levels of parathyroid hormone (PTH), calcitonin (CT), 25-hydroxycholecalciferol (25/OH/D), total calcium, magnesium, and alkaline phosphatase activity in 24 patients after renal transplantation. Twelve of these patients received cyclosporin with prednisone (group CyA) and other 12 were treated with azathioprine and prednisone (group Aza). Independently of the type of immunosuppression used, in both groups a significantly higher concentration of PTH, CT, 25/OH/D and greater activity of alkaline phosphatase were demonstrated in relation to healthy controls. In both studied groups the patients had also a significantly reduced calciuria and phosphatemia than controls. In group Aza the patients had a significantly lower phosphaturia and significantly higher magnesemia than in group CyA. The results of these investigations suggest a certain influence of the type of immunosuppression on the intensity of calcium-phosphate metabolism in renal graft recipients.
Nieszporek
T
T
Kliniki Nefrologii Sl. AM w Katowicach.
Kokot
F
F
Grzeszczak
W
W
Zukowska-Szczechowska
E
E
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001379:Azathioprine / Q000008:administration & dosage*; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D003524:Cyclosporins / Q000008:administration & dosage*; D005260:Female; D006082:Graft Enhancement, Immunologic; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000378:metabolism*
D003524:Cyclosporins; D010281:Parathyroid Hormone; D010710:Phosphates; D002116:Calcitonin; D000469:Alkaline Phosphatase; D001379:Azathioprine; D002118:Calcium
Zachowanie sie wybranych parametrów gospodarki wapniowo-fosforanowej u chorych po przeszczepieniu nerki leczonych azatiopryna lub cyklosporyna A.