Cordyceps Sinensis-I as an immunosuppressant in heterotopic heart allograft model in rats.
To investigate the inhibitory effects of Cordyceps Sinensis-I (CS-1) on the immune response responsible for the organ transplant rejection, we studied its effects of prolonging heterotopic heart allograft survival on rat model with heart graft; the effects of CS-1 were compared with those of cyclosporine A and glucocorticoid, and the possible pathological changes caused by CS-1 were observed. Our results showed that CS-1 can prolong the survival of grafted heart without causing infection, and it did not exert detrimental effects on vital organs. As a result, it proves to be a promising immunosuppressant in clinical organ transplantation in the future.
Zhang
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Institute of Organ Transplantation, Tongji Hospital, Tongji Medical University, Wuhan.
Xia
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D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis; D006084:Graft Rejection / Q000187:drug effects*; D016027:Heart Transplantation; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents