Polyclonal stimulation of lymphocytes induced by beta blockers in the mouse: influences of age, sex and strain.
The immune effects of acebutolol, a beta-blocker, are investigated in various strains of mice. In 6-12 weeks old C57Bl/6 female mice, an increase in the number of immunoglobulin secreting cells is observed only at the age of 9 weeks. At that age, such an effect is seen neither in C57Bl/6 male mice nor in female mice from 6 other strains including OF1 outbred mice. An increase in anti-trinitrophenol plaque forming cells is found in 9 week old C57Bl/6, Balb/c and CBA female mice.
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Laboratoire d'Immunopathologie Rénale et d'Immunopharmacologie, INSERM 88.01 CH LA GRAVE, Toulouse, France.
Lulé
J
J
Fournié
G J
GJ
D000070:Acebutolol / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity
D000070:Acebutolol