[The use of pharmacological screening for characterizing the toxicity of pertussis vaccines].
The influence of pertussis preparations, introduced by oral and parenteral routes, on the detoxifying function of the liver and the state of the nervous system of the animals was studied by methods used in pharmacology and toxicology. The use of these methods made it possible to find out side effects produced by corpuscular pertussis vaccine, introduced parenterally, on the detoxifying function of the liver and the state of the nervous system of the animals. The negative influence on the nervous system was more pronounced after the injection of the commercial adsorbed diphtheria-pertussis-tetanus vaccine used in this investigation than after the injection of pertussis monovaccine. The oral administration of corpuscular pertussis vaccine exerted no negative influence on the above-mentioned body functions of the animals.
Zakharova
N S
NS
Koval'skaia
S Ia
SIa
Ozeretskovskiĭ
N A
NA
Shepeleva
I B
IB
Britsina
M V
MV
Lobanova
A N
AN
Ozeretskovskaia
M N
MN
D000284:Administration, Oral; D000818:Animals; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine
Ispol'zovanie farmakologicheskogo skrininga dlia kharakteristiki toksichnosti kokliushnykh vaktsin.