title: Action of metronidazole on Entamoeba histolytica: an ultrastructural study.
abstract: Metronidazole (19 micrograms/ml) caused progressive increase in vacuolization in Entamoeba histolytica cells with disintegration of its plasma membrane leading to almost complete disappearance of the latter within 3 hours. The drug also induced formation of helical ribosomal aggregates in the cytoplasm and disappearance of button like structures inside the nucleus.
authors.affiliation: Central Drug Research Institute, Lucknow.
authors.forename: A
authors.initials: A
authors.lastname: Agrawal
authors.forename: S C
authors.initials: SC
authors.lastname: Maitra
authors.forename: A
authors.initials: A
authors.lastname: Arya
authors.forename: P
authors.initials: P
authors.lastname: Sagar
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D004748:Entamoeba histolytica / Q000187:drug effects* / Q000648:ultrastructure; D008795:Metronidazole / Q000494:pharmacology*; D008854:Microscopy, Electron; D014617:Vacuoles / Q000187:drug effects
chemical_list: D008795:Metronidazole