Leukocyte function-associated antigen 1 (LFA-1) is a signaling molecule for cytoskeletal changes in a human T cell line.
The HuT 78/2 clone is a human T cell clone which has an activated phenotype. When this line was stimulated with immobilized antibody to LFA-1, the majority of cells developed dendritic processes. These processes were demonstrated to contain cytoskeletal elements including microtubules and intermediate filaments. Phorbol myristate acetate synergized with and prolonged this effect. Thus, the LFA-1 molecule may function as a signaling molecule for cytoskeletal reorganization in a human T cell clone.
Kelleher
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Department of Clinical Medicine, Trinity College Dublin, St. James's Hospital, Ireland.
Murphy
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A
Cullen
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D
D000911:Antibodies, Monoclonal; D002460:Cell Line; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D007382:Intermediate Filaments / Q000502:physiology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000502:physiology*; D008870:Microtubules / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate
D000911:Antibodies, Monoclonal; D016169:Lymphocyte Function-Associated Antigen-1; D013755:Tetradecanoylphorbol Acetate