title: Case report 628: Low-grade central osteosarcoma.
abstract: In summary, low-grade central osteosarcoma is a clinically recognizable rare subtype of osteosarcoma, representing 1.9% of all osteosarcomas found at the Mayo Clinic. The lesion is locally aggressive but also has the potential for metastasis, particularly after local recurrence. The tumor may be difficult to distinguish radiographically and histologically from benign conditions, particularly fibrous dysplasia. This difficulty has led to inadequate treatment. In most cases, a wide surgical margin achieved by either local resection or amputation should result in a cure. Because of the low metastatic potential of the initial lesion, there seems to be no need for adjuvant chemotherapy.
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, MN 55905.
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
authors.forename: A M
authors.initials: AM
authors.lastname: Kurt
authors.forename: R A
authors.initials: RA
authors.lastname: McLeod
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging; D006801:Humans; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging* / Q000473:pathology