Lovastatin-acetaminophen subchronic toxicity in mice.
A subchronic, toxicity study of lovastatin-acetaminophen combination in s/w mice is reported. Oral administration of lovastatin in corn oil 30 mg/kg three times a week and acetaminophen 0.75% w/v in drinking water for 13 weeks resulted in significant increase in SGPT (ALT) in both male and female mice. Histopathology of the liver revealed centrilobular hepatocyte swelling. These results provide evidence of hepatic injury in s/w mice when concomitantly exposed to lovastatin and acetaminophen.
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Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York 11201.
Bhattacharya
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D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000473:pathology; D005260:Female; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008148:Lovastatin / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000082:Acetaminophen; D008148:Lovastatin; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase