[The modifying effect of ortho-cresol on benzo(a)pyrene-induced carcinogenesis in mice].
A modifying influence of ortho-cresol (o-cresol) on the carcinogenic effect of benzo(a)pyrene (B(a)P) in their combined peroral administration to CC57Br mice has been revealed. During the simultaneous administration of the o-cresol (1 mg) and B(a)P (1 mg) the rate of tumours, their multiplicity index, the degree of malignancy increased and the latent period shortened. In case of o-cresol administration before or after B(a)P (in the same doses) the decrease of carcinogenic effect has been revealed. In case of simultaneous administration of 10 mg of the o-cresol and 5 mg of the B(a)P the tumor incidence did not change in comparison with the animals of the control group which received only B(a)P. But their progression was hampered which was confirmed by a decrease of the malignancy rate, frequent occurrence and prolongation of the period of the malignization beginning.
Ianysheva
N Ia
NIa
Balenko
N V
NV
Chernichenko
I A
IA
Bakanova
G N
GN
Lemeshko
L P
LP
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D003408:Cresols / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D011092:Polyethylene Glycols / Q000633:toxicity; D013997:Time Factors
D003408:Cresols; D001564:Benzo(a)pyrene; C028914:triethylene glycol; D011092:Polyethylene Glycols; C034047:2-cresol
Modifitsiruiushchee vliianie orto-krezola na kantserogenez, indutsirovannyĭ benz(a)pirenom u mysheĭ.