title: Giant-cell reparative granuloma of the hand and foot bones.
abstract: Giant-cell reparative granuloma (GCRG) is an uncommon benign reactive intraosseous lesion. It occurs in the skull, jaw, hand, foot, and facial bones and rarely in other skeletal sites. It is a solitary, lytic, expanded lesion and infrequently may extend into the surrounding soft tissue. Histologically, it is composed of fibrous stroma with spindle-shaped fibroblasts, multinucleated giant cells, and inflammatory mononuclear cells. Areas of hemorrhage are uniformly present. It may be difficult to distinguish this entity from an aneurysmal bone cyst, giant-cell tumor, or brown tumor of hyperparathyroidism because of roentgenographic and histologic similarities. Accurate diagnosis is essential for appropriate treatment; serum calcium, phosphorus, and parathyroid hormone levels should be measured. Curettage and bone graft are effective treatments for both primary lesions and recurrences. Second recurrences are rare.
authors.affiliation: Department of Orthopaedic Surgery, Montefiore Medical Center, Bronx, New York 10467-2490.
authors.forename: V
authors.initials: V
authors.lastname: Ratner
authors.forename: H D
authors.initials: HD
authors.lastname: Dorfman
mesh_terms: D000293:Adolescent; D000368:Aged; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002648:Child; D005260:Female; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008663:Metacarpus; D008684:Metatarsus; D008875:Middle Aged; D011859:Radiography