[Biological effect of liposomes in hypoxic conditions of various etiologies].
The antihypoxic and antioxidative effects of phosphatidyl choline liposomes have been studied in hypoxic hypoxia, pneumonia, and acute blood loss. It was demonstrated that the body tolerance of persisting hypoxia increased on liposome administration due to elimination of lactate-acidosis, inhibition of lipid peroxidation and higher rate of oxygen diffusion through the biological barriers. The antihypoxic properties of the vesicles are determined by their remedial effect on the key mechanisms responsible for the development of hypoxic organ damage.
Stefanov
A V
AV
Pozharov
V P
VP
Miniaĭlenko
T D
TD
Bryginskiĭ
S A
SA
Seredenko
M M
MM
Lishko
V K
VK
D000818:Animals; D006470:Hemorrhage / Q000150:complications* / Q000378:metabolism; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008081:Liposomes / Q000627:therapeutic use*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D011014:Pneumonia / Q000150:complications* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D010713:Phosphatidylcholines
Biologicheskiĭ éffekt liposom pri gipoksicheskikh sostoianiiakh razlichnoĭ étiologii.