title: Can chlorpromazine prevent flap necrosis?
abstract: The influence of chlorpromazine hydrochloride on failing, cranially-based dorsal flaps of female rats (Uje:WIST) was studied. The drug was injected subcutaneously into the abdomen pre- and postoperatively. The dosage was 1.5 mg/100 g preoperatively and 0.75 mg/100 g body weight every 12 hours following flap replantation for 10 consecutive days. No improvement in the survival rate was achieved by administration of chlorpromazine hydrochloride in this rat strain.
authors.affiliation: Department of Maxillo-Facial Surgery and Plastic Surgery, Friedrich Schiller University, Jena, German Democratic Republic.
authors.forename: H D
authors.initials: HD
authors.lastname: Höft
authors.forename: P
authors.initials: P
authors.lastname: Oswald
authors.forename: A
authors.initials: A
authors.lastname: Tilgner
authors.forename: D
authors.initials: D
authors.lastname: Schumann
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D009336:Necrosis; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps / Q000473:pathology
chemical_list: D002746:Chlorpromazine