Some electrochemical characteristics of synthetic analogs of nucleic acid components. II. Derivatives of uridine and arabinosyluracil. An attempt to find correlation between some of their properties.
The relation between half-wave potentials E1/2, parameter tg alpha, and chemical structure of a series of natural and synthetic compounds of nucleic acids were studied. This series included the pyrimidine nucleobase uracil, the natural pyrimidine nucleoside uridine and its deoxy-derivatives, the synthetic analog arabinosyluracil, its deoxy- and thio-analogs, and some cyclonucleosides. It was confirmed that the value of tg alpha, which may suggest a potential carcinogenic activity of the compounds studied, is dependent upon lipophilicity and rate of biotransformation of these compounds. Generally, it was shown that the complexity of nucleoside molecules makes it impossible to find parameters showing correlation. Linear correlation was found only in small, structurally similar groups of derivatives.
Vachálková
A
A
Cancer Research Institute, Bratislava, Czechoslovakia.
Novotný
L
L
D001086:Arabinofuranosyluracil / Q000008:administration & dosage* / Q000737:chemistry; D004563:Electrochemistry; D011048:Polarography; D008063:Thioctic Acid / Q000494:pharmacology; D014498:Uracil / Q000737:chemistry; D014529:Uridine / Q000008:administration & dosage* / Q000737:chemistry
D001086:Arabinofuranosyluracil; D014498:Uracil; D008063:Thioctic Acid; D014529:Uridine