[Lung injuries and serial bronchoalveolar lavage findings in patients with summer-type hypersensitivity pneumonitis].
To evaluate acute lung injuries and their persistence in patients with summer-type hypersensitivity pneumonitis, repeated bronchoalveolar lavage (BAL) and pulmonary function tests were performed. BAL was performed on 36 occasions in 17 patients with hypersensitivity pneumonitis. Nineteen BAL procedures in 16 cases were done during the active phase within the three hospital day and BAL was repeated in 8 cases during inactive phase. Anti-Trichosporon cutaneum antibodies were detected in all of 15 cases examined using the Ouchterlony method and indirect immunofluorescent methods. The number of total BAL cells, lymphocyte and neutrophils were increased in the active phase, and OKT4/OKT8 was quite low (0.39). As the disease became inactive, the number of total BAL cells, lymphocytes and neutrophils decreased. On the other hand OKT4/OKT8 increased quickly. Significantly negative correlations were recognized between the number of BAL lymphocytes and %VC, and lymphocytes and %DLCO4. More improvements in BAL findings, %VC and %DLCO one year after acute episodes were seen in cases that moved house than cases that did not move, and these often relapsed. We concluded that complete clearing of the patient's house or moving out, if necessary, were needed to avoid relapse and persistent lung injuries.
Ishihara
K
K
Department of Respiratory Diseases, Kobe City General Hospital, Japan.
Tomioka
H
H
Hasegawa
T
T
Okazaki
M
M
Katakami
N
N
Sakamoto
H
H
Iwasaki
H
H
Umeda
B
B
Nakai
H
H
D000293:Adolescent; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis* / Q000276:immunology; D000908:Antibodies, Fungal / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009181:Mycoses; D012129:Respiratory Function Tests; D012621:Seasons; D014250:Trichosporon / Q000276:immunology*
D000908:Antibodies, Fungal