Effect of plasmapheresis on serum and CSF autoantibody levels in CNS paraneoplastic syndromes.
We compared the effect of plasmapheresis on antineuronal autoantibody titers in the serum and CSF of 3 patients with CNS paraneoplastic syndromes. Plasmapheresis reduced the serum autoantibody titer to 20% of the initial levels in the 3 patients, but the CSF autoantibody titer decreased only in the patient with severe damage of the blood-brain barrier.
Graus
F
F
Department of Neurology, Hospital Clinic Provincial, Spain.
Abos
J
J
Roquer
J
J
Mazzara
R
R
Pereira
A
A
D000368:Aged; D001323:Autoantibodies / Q000032:analysis* / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000276:immunology* / Q000628:therapy; D010956:Plasmapheresis; D013997:Time Factors
D001323:Autoantibodies