Impact of pretreatment (imprinting) with insulin on insulin-induced mitotic activity in Chang and CHO cell lines.
Primary interaction with insulin increased the mitotic activity of Chang liver and Chinese hamster ovary (CHO) cells. Re-exposure to insulin accounted for a significant increase of mitoses over the control, but for a considerable decrease thereof relative to the effect of primary exposure. The hormone had a more pronounced effect on its direct target cells (Chang liver cells) than on the CHO cells.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Török
O
O
D000818:Animals; D002460:Cell Line; D007328:Insulin / Q000502:physiology*; D008099:Liver / Q000166:cytology; D008938:Mitosis / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
D007328:Insulin