title: [A case report of mediastinal malignant lymphoma with long survival following combination chemotherapy using adriamycin, vincristine and cyclophosphamide].
abstract: Mediastinal B-cell malignant lymphoma of a 22-year-old female was successfully treated by combination chemotherapy including Adriamycin, Vincristine and Cyclophosphamide. She suffered from dyspnea and axillary tumor in September 1984. Roentgenological examination revealed a large anterior mediastinal tumor. Biopsy of the axillary tumor yielded a diagnosis of metastatic undifferentiated carcinoma from thymus by hematoxylin and eosin. Radiotherapy and chemotherapy including CDDP and ACNU resulted in a symptom-free period of only 2 months. Superior vena cava syndrome and massive pleural effusion recurred. Salvage chemotherapy including Adriamycin, Vincristine and Cyclophosphamide resulted in rapid therapeutic effect. Six courses of chemotherapy were administered, and she is alive and well 4 years after the first salvage chemotherapy. A definitive diagnosis of B-cell lymphoma was made after review of biopsy specimens using immunohistochemical procedures. To select adequate treatment for mediastinal malignant lymphoma, reliable diagnostic procedures including immunohistochemistry are needed. Intensive chemotherapy with appropriate drugs may obtain good response even in advanced cases, such as this.
authors.affiliation: Department of Surgery and Clinical Pathology, Tokyo Medical College Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Koshiishi
authors.forename: R
authors.initials: R
authors.lastname: Amemiya
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushima
authors.forename: O
authors.initials: O
authors.lastname: Taira
authors.forename: N
authors.initials: N
authors.lastname: Takizawa
authors.forename: K
authors.initials: K
authors.lastname: Oho
authors.forename: Y
authors.initials: Y
authors.lastname: Hayata
authors.forename: H
authors.initials: H
authors.lastname: Serizawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D011379:Prognosis; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide