title: Comparison of plain and Gd-DTPA-enhanced MR-imaging in children.
abstract: 40 children and adolescents (aged 1-16 years) were examined by MRI at 1.0 T. Gd-DTPA was given intravenously at a dose of 0.1 mmol/kg body weight. In all cases T1-weighted SE sequences were used to demonstrate contrast enhancement. No adverse effects were seen. 30 patients had one or more lesions; in 20 patients contrast enhancement was seen. In 4 cases lesions were not observed by plain MRI and could only be detected after Gd-DTPA. In addition, contrast enhancement provided additional information about the differentiation of lesion from edema or necrosis in 13 patients. Normal brain matter did not show any changes in signal intensity. However, an age-dependent signal increase was found in the normal vertebral bone marrow in all children. Gd-DTPA should be used as a supplementary examination whenever a tumor or an infectious disease of the CNS is suspected and plain MRI is normal, or when origin and extent of a lesion cannot be adequately defined with plain MRI.
authors.affiliation: Radiologische Klinik und Poliklinik, Klinikum Grosshadern, München, FRG.
authors.forename: P
authors.initials: P
authors.lastname: Baierl
authors.forename: A
authors.initials: A
authors.lastname: Mühlsteffen
authors.forename: J
authors.initials: J
authors.lastname: Haustein
authors.forename: W M
authors.initials: WM
authors.lastname: Bauer
authors.forename: C
authors.initials: C
authors.lastname: Förster
authors.forename: H
authors.initials: H
authors.lastname: Fendel
authors.forename: H P
authors.initials: HP
authors.lastname: Niendorf
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis*; D002493:Central Nervous System Diseases / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013120:Spinal Cord Neoplasms / Q000175:diagnosis*
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA