title: Dissociation between sympathetic purinergic response and ATP response in the mesenteric artery of the dog.
abstract: In the presence of prazosin and propranolol, electrical transmural stimulation of isolated dog mesenteric artery produced a sympathetic purinergic contraction, which was followed by a relaxation in PGF2 alpha-contracted arteries. Such purinergic responses were mimicked by brief exposure to alpha, beta-methylene ATP (alpha, beta-Me ATP) and were completely inhibited after desensitization of P2x-purinergic receptors. However, exogenous ATP predominantly evoked a relaxation in PGF2 alpha-contracted artery. These results suggest that the sympathetic purinergic response may be caused by a P2x-purinergic receptor-selective mechanism or substance, rather than ATP.
authors.affiliation: Department of Pharmacology, Fukui Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Muramatsu
authors.forename: S
authors.initials: S
authors.lastname: Kigoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011983:Receptors, Purinergic / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D011433:Propranolol; D015237:Dinoprost; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D011224:Prazosin