title: Hyperlactatemia and increasing metabolic acidosis in hepatorenal failure treated by hemofiltration.
abstract: We report a case of increasing hyperlactatemia in the course of repeated treatment by machine hemofiltration (MHF) using a lactate-buffered replacement solution. The hyperlactatemia was associated with a reduction in mean arterial pressure, and in the majority of treatments a metabolic acidosis developed. Hyperlactatemia due to exogenous lactate may not be as benign as previously discussed.
authors.affiliation: Department of Renal Medicine, St. Jame's University Hospital, Leeds, England.
authors.forename: A
authors.initials: A
authors.lastname: Davenport
authors.forename: K
authors.initials: K
authors.lastname: Aulton
authors.forename: R B
authors.initials: RB
authors.lastname: Payne
authors.forename: E J
authors.initials: EJ
authors.lastname: Will
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology*; D000368:Aged; D002021:Buffers; D015314:Dialysis Solutions; D005260:Female; D006440:Hemofiltration; D006530:Hepatorenal Syndrome / Q000628:therapy*; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid
chemical_list: D002021:Buffers; D015314:Dialysis Solutions; D007773:Lactates; D019344:Lactic Acid