The initial vasodilation and the later vasoconstriction of endothelin-1 are selective to specific vascular beds.
The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown.
Hoffman
A
A
Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892.
Grossman
E
E
Ohman
K P
KP
Marks
E
E
Keiser
H R
HR
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D016232:Endothelins / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011921:Rats, Inbred WKY; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D016232:Endothelins