title: Single-dose effects of ibopamine hydrochloride on renal function in patients with congestive heart failure.
abstract: To examine the renal effects of ibopamine HCl we evaluated 15 patients with New York Heart Association Class II-III congestive heart failure and mild renal insufficiency (creatinine clearance [CLcr] = 45-85 ml min-1). Diuretics and vasodilators were withheld and a sodium (Na+)-restricted diet was initiated. All patients exhibited positive Na+ balance at the time of evaluation. Hourly urine volumes, urine chemistries, serum chemistries, PAH and inulin/iothalamate clearances were determined 2 h pre and 4 h post a single 200 mg oral dose of ibopamine. Effective renal plasma flow, creatinine clearance, filtration fraction, and the fractional excretion of sodium and potassium were not significantly altered postdose. A significant increase in urine output and decrease in urine osmolality were seen at all time points postdose. A significant reduction in serum potassium (2 and 3 h) and blood urea nitrogen (1, 3 and 4 h) concentrations occurred. Measurements of glomerular filtration rate by inulin or [125I]-iothalamate produced differing results in the patient groups studied. We conclude that a single dose of ibopamine does not produce significant improvements in renal function in patients with congestive heart failure, mild renal insufficiency and positive sodium balance.
authors.affiliation: Department of Pharmacy, Wade Park Veterans Administration Medical Center, Cleveland, Ohio 44106.
authors.forename: R J
authors.initials: RJ
authors.lastname: Kasmer
authors.forename: R E
authors.initials: RE
authors.lastname: Cutler
authors.forename: M A
authors.initials: MA
authors.lastname: Munger
authors.forename: R C
authors.initials: RC
authors.lastname: Jarvis
authors.forename: D
authors.initials: D
authors.lastname: Hricik
authors.forename: A R
authors.initials: AR
authors.lastname: Nara
authors.forename: P
authors.initials: P
authors.lastname: Goldberg
authors.forename: J A
authors.initials: JA
authors.lastname: Green
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy*; D000284:Administration, Oral; D000368:Aged; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000652:urine
chemical_list: D004232:Diuretics; C023487:ibopamine; D012964:Sodium; D003846:Deoxyepinephrine; D011188:Potassium