New active analogues of vitamin D with low calcemic activity.
In conclusion, a number vitamin D analogues have been developed that have very low calcemic activity but retain several other properties of 1,25-(OH)2D3, including the ability to differentiate leukemia and skin cells, to enhance the immune response, and to suppress parathyroid hormone levels. Although the mechanism of this selective activity is not yet clear, these analogues may provide new insights into the differences in action of 1,25-(OH)2D3 in various target tissues. Most importantly, the selective action of these analogues may be exploited for the treatment of diseases such as leukemia, psoriasis and hyperparathyroidism.
Brown
A J
AJ
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Finch
J L
JL
Lopez-Hilker
S
S
Dusso
A
A
Ritter
C
C
Pernalete
N
N
Slatopolsky
E
E
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D006961:Hyperparathyroidism / Q000188:drug therapy; D007938:Leukemia / Q000188:drug therapy; D011565:Psoriasis / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; C055085:calcipotriene; D002117:Calcitriol; C051883:maxacalcitol