[Pharmacogenetics for the practicing physician].
An important source of interindividual differences in drug action are inherited differences in the pharmacokinetics and pharmacodynamics of many drugs. Besides some well-known but rarely occurring examples of unusual drug action, the inherited variations of drug metabolism are of particular clinical importance, as a relationship between the defect of metabolism and the effects and toxicity of the drugs involved has been observed. Recent investigations were able to elucidate many of the molecular mechanisms responsible for these genetic defects.
Bargetzi
M
M
Departement für Innere Medizin, Kantonsspital Basel.
D006801:Humans; D008661:Metabolism, Inborn Errors / Q000235:genetics*; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D010600:Pharmacology
Pharmakogenetik für den praktizierenden Arzt.