[Pollinosis and bronchial asthma: pathogenesis, immunology, clinical aspects].
Rhinoconjunctivitis induced by pollen exposure and bronchial asthma are generally easily recognizable clinically. In asthma a number of differential diagnoses such as ciliary dyskinesia, cystic fibrosis and gastro-oesophageal reflux must be considered. The predominant symptoms are coughing and wheezing. Investigations into the complex nature of mediator release and IgE synthesis have established a predominantly inflammatory pattern of reactions largely responsible for induction and maintenance of bronchial hyperresponsiveness due to both acute and chronic processes. Future therapeutic consequences may be derived from anti-inflammatory strategies. This has already lead to reassessment and upgrading of use of corticosteroids in paediatric asthma.
Götz
M
M
Universitäts-Kinderklinik Wien.
Sanz
K
K
D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D002925:Ciliary Motility Disorders / Q000175:diagnosis; D003550:Cystic Fibrosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005764:Gastroesophageal Reflux / Q000175:diagnosis; D006801:Humans; D008407:Mast Cells / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000276:immunology
D000485:Allergens
Pollinosis und Asthma bronchiale: Pathogenese, Immunologie, Klinik.