Depressive effect of a Taenia solium cysticercus factor on cultured human lymphocytes stimulated with phytohaemagglutinin.
Cysticercosis caused by Taenia solium is associated with immunodepression of T and B lymphocytes. In order to ascertain if this parasite affects lymphocyte activity, a factor isolated from the parasite was tested on (3H) thymidine uptake by cultured human lymphocytes stimulated by phytohaemagglutinin. This dialysable factor had a molecular weight of less than 3500 Da, and was isolated from an extract of Cysticercus cellulosae. It decreased phytohaemagglutinin-stimulated uptake of (3H) thymidine. After the material was treated with RNase 'A', the suppressive activity was destroyed. It thus appears that the factor could correspond to an RNA fraction.
Molinari
J L
JL
Departamento de Microbiología e Inmunología, Universidad Nacional Autónoma de México.
Tato
P
P
Reynoso
O A
OA
Cázares
J M
JM
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D002478:Cells, Cultured; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008970:Molecular Weight; D010835:Phytohemagglutinins; D012260:Ribonucleases / Q000378:metabolism; D013621:Taenia / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D001685:Biological Factors; D010835:Phytohemagglutinins; D014316:Tritium; D012260:Ribonucleases; D013936:Thymidine