title: [Effect of nitrendipine on the function of the upper gastrointestinal tract].
abstract: A double-blind crossover-trial comparing the influence of orally administered nitrendipine and placebo on the function of the upper gastrointestinal tract was carried out in ten healthy volunteers. Esophageal motility, intestinal transit time, size and motility of the gallbladder, serum gastrin levels and gastric secretion (basal and after stimulation with pentagastrin) were determined. No statistically significant differences between nitrendipine and placebo could be observed. Most parameters remained unchanged in both groups. Serum gastrin levels slightly increased after nitrendipine but did not exceed the normal range. The results demonstrate that nitrendipine given in an antihypertensive dosage, in contrast to other calcium antagonists, does not influence the function of the upper gastrointestinal tract.
authors.affiliation: Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Universitätsklinikum Rudolf-Virchow, Berlin-Charlottenburg.
authors.forename: H D
authors.initials: HD
authors.lastname: Janisch
authors.forename: S
authors.initials: S
authors.lastname: Trabhardt
authors.forename: D
authors.initials: D
authors.lastname: von Kleist
mesh_terms: D000328:Adult; D004947:Esophagus / Q000187:drug effects*; D005704:Gallbladder / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008365:Manometry; D009568:Nitrendipine / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D005755:Gastrins; D009568:Nitrendipine
vernacular_title: Einfluss von Nitrendipin auf die Funktion des oberen Gastrointestinaltrakts.