title: Efficacy of toltrazuril in broilers and development of a laboratory model for sensitivity testing of Eimeria field isolates.
abstract: (1) The efficacy of toltrazuril (Baycox) against coccidiosis was established on a broiler farm in an intermittent application during five consecutive growing periods. Treated birds were fed a broiler ration without anticoccidials. The efficacy of Baycox was compared with the nicarbazin-salinomycin shuttle. It was concluded that Baycox retarded the onset of Eimeria infection for several weeks. During the fifth rearing period coccidiosis problems emerged on the farm in all birds during medication, suggesting development of resistance. (2) During a laboratory experiment the efficacy of Baycox was studied in birds after inoculation with different numbers of oocysts at 7, 10 or 15 days of age. Baycox was applied at 10 and 11 days of age. In all cases medication with Baycox protected birds from coccidiosis during a period of at least 7 days. This effect of Baycox could be due to the long-existing tissue levels of the product and its metabolites as well as its specific effect on the second generation of schizonts. (3) In another laboratory experiment coccidia obtained from field trials were tested for sensitivity to Baycox in conjunction with two strains obtained from farms were coccidiosis emerged during application. The inoculation model developed in this study was used for sensitivity testing. One of the Eimeria strains tested was resistant to the product, one strain was tolerant and the remaining two strains, including the control strain, were fully sensitive to Baycox.
authors.affiliation: Poultry Health Institute, Doorn, The Netherlands.
authors.forename: M H
authors.initials: MH
authors.lastname: Vertommen
authors.forename: H W
authors.initials: HW
authors.lastname: Peek
authors.forename: A
authors.initials: A
authors.lastname: van der Laan
mesh_terms: D000818:Animals; D001835:Body Weight; D002432:Cecum / Q000469:parasitology; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects / Q000302:isolation & purification; D005243:Feces / Q000469:parasitology; D008297:Male; D009528:Nicarbazin / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy*; D011714:Pyrans / Q000627:therapeutic use; D014227:Triazines / Q000494:pharmacology / Q000627:therapeutic use*; D000095662:Polyether Polyketides
chemical_list: D003049:Coccidiostats; D009528:Nicarbazin; D011714:Pyrans; D014227:Triazines; C010327:salinomycin; D000095662:Polyether Polyketides; C036670:toltrazuril