The role of polyamines as a marker of tumor progression and regression in experimental tumors.
The pattern of changes in the polyamine spectrum has been studied under the stress of Sarcoma 180, a transplanted tumor growing in the peritoneal cavity of mice. Retinol, a known inhibitor of ornithine decarboxylase, was used to modulate tumor growth pattern and subsequent changes in the level of polyamines. The polyamine levels showed an increase during tumor proliferation. In the treated group, however, the enhanced levels exhibited a tendency to decrease, along with tumor inhibition, indicating that a positive correlation exists between the polyamine content in the red blood cells of mice and the tumor growth pattern.
Sen
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Chittaranjan National Cancer Research Centre, Calcutta, India.
Guha
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D000818:Animals; D014408:Biomarkers, Tumor; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D051379:Mice; D011073:Polyamines / Q000097:blood*; D011700:Putrescine / Q000097:blood; D013095:Spermidine / Q000097:blood; D013096:Spermine / Q000097:blood; D014801:Vitamin A / Q000494:pharmacology
D014408:Biomarkers, Tumor; D011073:Polyamines; D014801:Vitamin A; D013096:Spermine; D013095:Spermidine; D011700:Putrescine