title: Normeperidine-induced seizures in hereditary coproporphyria.
abstract: Seizures are common in acute exacerbations of hepatic porphyria, even though the etiology is not identified in most cases. We have reported a case of normeperidine-induced seizures in a patient with hereditary coproporphyria. Although meperidine is commonly used for pain control during acute attacks in these patients, this report suggests that meperidine is not a good analgesic choice in porphyria. Normeperidine-induced seizures in patients with porphyria may be treated by withdrawal of meperidine therapy and selective use of anticonvulsants.
authors.affiliation: Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: M A
authors.initials: MA
authors.lastname: Deeg
authors.forename: K
authors.initials: K
authors.lastname: Rajamani
mesh_terms: D000328:Adult; D002800:Cholinesterase Inhibitors / Q000009:adverse effects*; D003306:Coproporphyrins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D008614:Meperidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D011164:Porphyrias / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D002800:Cholinesterase Inhibitors; D003306:Coproporphyrins; D008614:Meperidine; C002752:normeperidine