Serum levels of glycated albumin in non-diabetic and insulin-dependent diabetic children.
The serum levels of glycated albumin (GA) in 83 non-diabetic children and 26 children with insulin-dependent diabetes mellitus (IDDM) were measured by high-performance liquid chromatography (HPLC). In non-diabetic children over one year, the GA levels were found to be uninfluenced by age, while the fructosamine (FRA) levels increased with age. The mean level of GA in IDDM children was 39.1 +/- 9.1%, which was significantly higher than in non-diabetic children with values of 16.1 +/- 1.1% (p less than 0.01). The GA levels of non-diabetic and IDDM children did not overlap, whereas their FRA levels did overlap. The GA levels correlated with HbAlc levels (r = 0.74, p less than 0.01) and FRA levels (r = 0.66, p less than 0.01) in IDDM children. The GA levels were more closely correlated than the FRA levels with the blood glucose two and three weeks previously. Thus, the GA level is a useful indicator of short-term control in diabetes mellitus.
Miyamoto
N
N
Department of Pediatrics and Laboratory Medicine, University of Tokushima, School of Medicine, Japan.
Shirakawa
N
N
Kuroda
Y
Y
Abe
F
F
Shima
K
K
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008297:Male; D012709:Serum Albumin / Q000032:analysis*; D000093423:Glycated Serum Albumin
D019270:Fructosamine; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006595:Hexosamines; D012709:Serum Albumin; D000093423:Glycated Serum Albumin