title: [The effect of mepacrine and propranolol on lipid level in the alveolar surfactant during anaphylactic shock].
abstract: It is shown that the development of anaphylactoid shock in rats is connected with a decrease of the surface activity of alveolar surfactant and liberation of arachidonic acid from pulmonary surfactant phospholipids. Preventive injection of lipomodulators--A2 phospholipase inhibitor (mepacrine) or triglycecolipase inhibitor (propranolol)--to animals normalizes the level of lipids in the surfactant and blocks liberation of arachidonate and palmitate from surfactant phospholipids in an anaphylactoid shock.
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Bashmakov
authors.forename: T S
authors.initials: TS
authors.lastname: Briuzgina
mesh_terms: D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000187:drug effects / Q000378:metabolism*; D011796:Quinacrine / Q000494:pharmacology*; D051381:Rats
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D011663:Pulmonary Surfactants; D011433:Propranolol; D011796:Quinacrine
vernacular_title: Vliianie mepakrina i propranolola na soderzhanie lipidov v al'veoliarnom surfaktante pri anafilaktoidnom shoke.