[Attenuation of the effect of imizin on the dynamics of forced swimming and the circadian rhythm of mobility in rats chronically administered melatonin].
Imizine (10 mg/kg, 14 days) was shown to change the temporal dynamics of forced swimming in rats and to decrease the biorhythmical index of depression. The antidepressant also produced reorganization of the circadian rest-activity rhythm with the acrophase shift for the late night hours. A pineal hormone melatonin (1 and 10 mg/kg, 7 days) administered in combination with imizine attenuated the main rhythmic indices of its action and precipitated the occurrence of tolerance.
Ovanesov
K B
KB
Baturin
V A
VA
Arushanian
E B
EB
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D013550:Swimming; D013997:Time Factors
D008550:Melatonin; D007099:Imipramine
Oslablenie vliianiia imizina na dinamiku prinuditel'nogo plavaniia i tsirkadiannogo ritma podvizhnosti u krys pri khronicheskom vvedenii melatonina.