[Changes in the activity of different classes of enzymes in the cerebral cortex of rats in ontogeny and after the transplantation of embryonic nerve tissue].
The activity of lactate dehydrogenase (LDH), indophenol oxidase, aspartate aminotransferase (AsAT), alkaline phosphatase, acid phosphatase and aldolase at different stages of rat development was measured. We have also determined changes in the activity of these enzymes resulting from transplantation of embryonic nerve tissue (ENT) into the brain of adult animals. During development from the embryo to the adult animal, LDH and AsAT activities increased, while alkaline phosphatase activity diminished. After ENT transplantation, the most prominent changes were in the alkaline phosphatase activity whereas the activity of LDH, AsAT and acid phosphatase remained unchanged and similar to that in the brain cortex of intact adult animals. Changes in the enzyme activity resulting from ENT transplantation changed in a manner characteristic of the transplant. Local brain damage did not change the activity of the studied enzymes fifty days after surgery.
Ivanov
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D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology* / Q000601:surgery; D004622:Embryo, Mammalian; D006128:Growth / Q000502:physiology*; D009417:Nerve Tissue / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
Izmenenie aktivnosti raznykh klassov fermentov v kore mozga krys v ontogeneze i posle transplantatsii émbrional'noĭ nervnoĭ tkani.