title: Calcitonin: chronotherapeutic effect on osteopenia in the ovariectomized rat.
abstract: This chronotherapeutic study has revealed no clear evidence to support the concept that calcitonin promotes bone formation in intact or OVX'd rats. Rather, the efficacy of CT-impaired bone resorption appeared to be optimal in OVX'd rats treated during the daytime, and least effective during the first half of the environmental dark span. These findings indicate a benefit for calcitonin chronotherapy in this animal model where the cellular kinetics resemble those documented in early development of postmenopausal osteoporosis.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, Galveston 77550.
authors.forename: D J
authors.initials: DJ
authors.lastname: Simmons
authors.forename: C
authors.initials: C
authors.lastname: Yang
authors.forename: C M
authors.initials: CM
authors.lastname: Gundberg
authors.forename: L
authors.initials: L
authors.lastname: Kidder
authors.forename: G
authors.initials: G
authors.lastname: Cornelissen
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Lozano
authors.forename: E
authors.initials: E
authors.lastname: Sandstead
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001862:Bone Resorption / Q000503:physiopathology; D002116:Calcitonin / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology*; D004334:Drug Administration Schedule; D005260:Female; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D010758:Phosphorus / Q000097:blood; D051381:Rats
chemical_list: D010758:Phosphorus; D002116:Calcitonin; D002118:Calcium