title: Effect of gelatin infusions on blood serum lipid pattern.
abstract: The effect of gelatin infusions in rat on the various serum lipid constituents was studied by measuring the mean values of total lipids, lipoprotein lipase, triglycerides, phospholipids, cholesterol, non-esterified fatty acids, and lipoproteins. These measurements were made immediately following a single intravenous infusion of gelatin solution (1 ml/100 g body wt) and at different time intervals post-infusion. Repeated intravenous infusions of gelatin were also given to another group of rats and the above mentioned lipid constituents were measured 24 h after each dose. The results obtained showed that gelatin infusions have a definite hypolipemic effect. There was a significant reduction in the levels of total lipids, triglycerides, cholesterol, and B + preB/alpha ratios immediately following infusion and at 5, 24 and 48 h postinfusion. This reduction was transient and the values were gradually normalized at the end of the first week postinfusion. In rats receiving repeated i.v. infusions, the results obtained showed a significant decrease in the same lipid constituents during the whole month of gelatin administration. Values of lipoprotein lipase, lipid phosphorous and non-esterified fatty acids showed insignificant changes from baseline values at all time intervals following single and repeated i.v. infusions of gelatin solution.
authors.affiliation: Medical Research Institute, Alexandria University, Egypt.
authors.forename: Y
authors.initials: Y
authors.lastname: Gabr
authors.forename: A
authors.initials: A
authors.lastname: Michael
authors.forename: S
authors.initials: S
authors.lastname: Dawoud
authors.forename: L
authors.initials: L
authors.lastname: Fahmy
authors.forename: N
authors.initials: N
authors.lastname: Assem
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005780:Gelatin / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides; D005780:Gelatin; D002784:Cholesterol