[Disulfiram-like effect of cefonicid: first observation].
The disulfiram-like reaction is linked to the assumption of ethyl alcohol during therapy with the cephalosporin latamoxef, cefamandole and cefoperazone. The reaction is commonly ascribed to the methyl-thiotetrazole group, resembling part of the disulfiram molecule. We describe the case of a patient who experienced on two different occasions a disulfiram-like effect during therapy with cefonicid. This cephalosporin contains the methylsulphothiotetrazole group in place of the methylthiotetrazole group. Our observation is the first related to cefonicid.
Marcon
G
G
Divisione di Medicina generale, ULSS 17 Veneto, Ospedale, Mirano.
Spolaor
A
A
Scevola
M
M
Zolli
M
M
Carlassara
G B
GB
D000368:Aged; D000428:Alcohol Drinking; D015790:Cefonicid / Q000009:adverse effects*; D004221:Disulfiram; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male
D000431:Ethanol; D015790:Cefonicid; D004221:Disulfiram
Effetto disulfiram-simile da Cefonicid: prima segnalazione.