[Reversible ophthalmoplegia, cerebellar syndrome and vigilance disorders following phenytoin poisoning].
A 20-year-old man developed marked ophthalmoplegia and cerebellar symptoms after suicidal intoxication with phenytoin (maximal plasmatic level 73.6 mg/l). Symptoms of toxicity completely resolved with supportive care and with activated charcoal. The clinical picture of acute phenytoin intoxication is reviewed. The most common disorders are ataxia, nystagmus and mental status changes, but ophthalmoplegia is rare.
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Service de neurologie, Centre hospitalier universitaire vaudois, Lausanne.
Uldry
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Regli
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D000328:Adult; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D002606:Charcoal / Q000627:therapeutic use; D003072:Cognition Disorders / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009886:Ophthalmoplegia / Q000139:chemically induced*; D010672:Phenytoin / Q000097:blood / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D013406:Suicide, Attempted
D002606:Charcoal; D010672:Phenytoin
Ophtalmoplégie, syndrome cérébelleux et troubles de la vigilance réversibles après intoxication à la phénytoïne.