title: [Growth catch-up in the case of congenital hypothyroidism after delayed treatment--a case report].
abstract: We report a case of congenital hypothyroidism, presenting with growth and mental retardation since childhood, but in which the diagnosis was not made until he was 17 years old. Because of such an unusually long delay in treatment, we focussed on the growth catch-up. This included the change of skeletal growth, puberty and mentality after a 4-year treatment period. He was 114 cm in height (height age 5.5 years) with the upper segment measuring 60 cm and lower segment 54 cm (U/L ratio 1.1). His bone age was that of a six year old and he had no secondary sexual characteristics. IQ testing showed a full scale IQ of 68, verbal IQ 74 and performance IQ 64. After 4 years of treatment, his height caught up to 152 cm (height age 12.5 years), with the upper segment 77.2 cm, and that of lower segment 74.8 cm (U/L ratio 1.03). The bone age had advanced to that of a 17 year old. His pubic hair emerged after 18 months of therapy (at a chronologic age of 18.5 years), accompanied by a normalization of testosterone and a normal response to a GnRH test. His IQ test was rechecked after 2 years of treatment. His full scale IQ was 78, verbal IQ 77 and performance IQ 83. In the mean time, the patient got a job being more alert, active and self-confident following his growth catch-up.
authors.affiliation: Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
authors.forename: G W
authors.initials: GW
authors.lastname: Chen
authors.forename: H S
authors.initials: HS
authors.lastname: Huang
authors.forename: P W
authors.initials: PW
authors.lastname: Wang
authors.forename: J D
authors.initials: JD
authors.lastname: Lin
authors.forename: B Y
authors.initials: BY
authors.lastname: Huang
authors.forename: M J
authors.initials: MJ
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D003409:Congenital Hypothyroidism; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine