title: The history and rationale of hormone replacement therapy.
abstract: Robert Wilson rendered women aged over 45 a great service. He provoked a line of research which has in 25 years resulted in a sensible approach towards the use of medication in treating the climacteric and post-menopausal oestrogen deficiency. The history of hormone replacement therapy (HRT) is described, as is the current approach to rational HRT. Some ideas are outlined for future development.
authors.affiliation: International Menopause Society, Brussels, Belgium.
authors.forename: P A
authors.initials: PA
authors.lastname: van Keep
mesh_terms: D002979:Climacteric / Q000187:drug effects; D015914:Estrogen Replacement Therapy / Q000266:history; D005260:Female; D049673:History, 20th Century; D006801:Humans; D008875:Middle Aged