title: Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.
abstract: Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates.
authors.affiliation: Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN.
authors.forename: D C
authors.initials: DC
authors.lastname: Montefiori
authors.forename: W E
authors.initials: WE
authors.lastname: Robinson
authors.forename: V M
authors.initials: VM
authors.lastname: Hirsch
authors.forename: A
authors.initials: A
authors.lastname: Modliszewski
authors.forename: W M
authors.initials: WM
authors.lastname: Mitchell
authors.forename: P R
authors.initials: PR
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D002520:Cercopithecidae; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology*; D003429:Cross Reactions; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D015704:CD4 Antigens; D003165:Complement System Proteins