Variation of alpha 1-antitrypsin glycoprotein microheterogeneity in hepatic postresuscitation disease.
Microheterogeneity of the glycoprotein alpha 1-antitrypsin has been investigated sequentially by high resolution isoelectric focusing in a child with the proteinase inhibitor MS phenotype after near-drowning. A band-splitting with additional cathodal fractions exhibited migration from the most cathodic to the anodic positions of the glycoprotein isoforms in the course of post-resuscitation disease. The pattern may reflect the time- and stage-dependent hypoxic and post-hypoxic effects on hepatocellular metabolic zonation.
Heyne
K
K
Klinik für Pädiatrie, Medizinische Universität zu Lübeck, Federal Republic of Germany.
Tegtmeyer
F K
FK
Weidinger
S
S
D006801:Humans; D007223:Infant; D007511:Ischemia / Q000378:metabolism*; D007525:Isoelectric Focusing; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D015701:Near Drowning; D010641:Phenotype; D012151:Resuscitation; D000515:alpha 1-Antitrypsin / Q000737:chemistry* / Q000235:genetics
D000515:alpha 1-Antitrypsin