The effect of pitressin and glypressin in variceal bleeding--a preliminary clinical trial.
Effects of hemostatic and various side effects were compared between glypressin and pitressin. Fifty-five episodes of esophageal variceal bleeding in 29 patients were studied. Although the glypressin group included more patients in Pugh's classification C than the pitressin group, the result of hemostasis was not influenced. The effect of hemostasis was evaluated in 24 episodes receiving either glypressin or pitressin. The hemostatic effects of glypressin and pitressin were 6/11, 54.5% and 7/13, 53.8% respectively. Eighteen episodes in six patients, with multiple episodes, were used to observe the effect of these two drugs in the same person. No difference was observed. The number of side effects in the glypressin group and the pitressin group were 5 and 10 respectively. Although the side effects of glypressin might be fewer than those of pitressin, chest pain was observed in patients receiving glypressin treatment. The use of glypressin in the patients with cardiac diseases should be studied further. Glypressin is more convenient in clinical use. However, pitressin doses is easily modified. Both drugs might be selected in the control of variceal bleeding.
Chen
S C
SC
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Lin
Z Y
ZY
Lu
S N
SN
Chuang
W L
WL
Hsieh
M Y
MY
Wang
L Y
LY
Tsai
J F
JF
Chang
W Y
WY
D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000188:drug therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077585:Terlipressin; D014667:Vasopressins / Q000627:therapeutic use*
D006490:Hemostatics; D014667:Vasopressins; D008236:Lypressin; D000077585:Terlipressin