Characteristics of chronic insomniacs examined in a multicenter 14-day study of flurazepam and midazolam.
One hundred seven chronic insomniacs (41 men, 66 women; mean age, 37.9 years) with a history of use of benzodiazepines were recruited for a multicenter study testing the relative efficacy of flurazepam 15 mg or 30 mg, midazolam 15 mg, or placebo during a 14-day treatment period. Average duration of the complaint of insomnia was 13.5 years. Most (74%) of the patients met criteria for a diagnosis of persistent psychophysiological sleep disorder for both initiating and maintaining sleep.
Roth
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Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan 48202.
Roehrs
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Linnoila
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Judd
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D000328:Adult; D000339:Affect / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D005479:Flurazepam / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects
D005479:Flurazepam; D008874:Midazolam