title: Relationship of oxygen dose to angiogenesis induction in irradiated tissue.
abstract: This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.
authors.affiliation: Division of Oral and Maxillofacial Surgery, University of Miami School of Medicine/Jackson Memorial Medical Center, Florida.
authors.forename: R E
authors.initials: RE
authors.lastname: Marx
authors.forename: W J
authors.initials: WJ
authors.lastname: Ehler
authors.forename: P
authors.initials: P
authors.lastname: Tayapongsak
authors.forename: L W
authors.initials: LW
authors.lastname: Pierce
mesh_terms: D000388:Air; D000818:Animals; D001274:Atmospheric Pressure; D003097:Collateral Circulation / Q000187:drug effects; D006931:Hyperbaric Oxygenation; D008297:Male; D010100:Oxygen / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D010100:Oxygen