title: Lack of expression of antigens for islet cell antibodies in rat fetal pancreas.
abstract: It is not clear yet when pancreatic islet cells begin to express antigens for islet cell antibodies (ICA). Therefore, we studied whether human ICA-positive sera, crossreacting with adult rat islet cells, react with fetal and neonatal rat islet cells immunohistologically. The ICA did not react with fetal islet cells. On the other hand, neonatal islet cells over 2-3 weeks of age expressed the reactivities almost similar to those of the adult. It was suspected that pancreatic islet cells started to express their antigens to induce ICA gradually after birth.
authors.affiliation: Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashiro
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Aono
authors.forename: G
authors.initials: G
authors.lastname: Isshiki
authors.forename: T
authors.initials: T
authors.lastname: Jinnouchi
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D005333:Fetus / Q000276:immunology; D010179:Pancreas / Q000737:chemistry* / Q000196:embryology / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000941:Antigens; D001323:Autoantibodies; D001798:Blood Proteins; C024211:islet cell antibody