Influence of feeding on the bioavailability of ronidazole prolonged-release formulations in pigeons.
The influence of feeding on the bioavailability of ronidazole (5 mg per animal) formulated as a hydrophilic-matrix tablet or as lipophilic pellets, was evaluated in pigeons. Administered to fed pigeons, prolonged drug absorption was obtained for both formulations. In non-fed pigeons an immediate grinding of the formulations in the gizzard resulted in rapid drug absorption. This indicates that prolonged residence of the prolonged-release formulations in the crop obtained in the fed condition seemed the only possible means of obtaining prolonged drug release in pigeons.
Baert
L
L
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
Herman
J
J
Remon
J P
JP
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D010856:Columbidae / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004435:Eating / Q000502:physiology*; D005260:Female; D005895:Gizzard, Avian / Q000502:physiology; D008297:Male; D012385:Ronidazole / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D012385:Ronidazole