title: Left ventricular wall stress distribution in chronic pressure and volume overload: effect of normal and depressed contractility on regional stress-velocity relations.
abstract: Regional stress-velocity relations were determined in a first group of patients (n = 15) with normal (five controls, five patients with aortic stenosis, and five patients with aortic insufficiency) and a second group of patients (n = 10) with depressed contractility (five patients with aortic stenosis and five with aortic insufficiency). LV circumferential wall stress was calculated from high-fidelity pressure and frame-by-frame angiocardiographic data using the Wong thick-wall model. Regional wall stress and shortening velocity were calculated from the endo- to the epicardium, and from the equator to the apex at 35 points. Regional LV wall stress was in all patients lower at the epi- than the endocardium, and lower at the apex than the equator. Regional stress-velocity relations were downward shifted from the endo- to the epicardium and from the equator to the apex (family of curves) in both groups. At corresponding LV regions stress-velocity relations showed significantly smaller slopes and intercepts (downward depression) in group 2 than in group 1. Thus, wall stress distribution is inhomogeneous in the normal, as well as in the pressure and volume overloaded left ventricle. Regional differences in stress-velocity relations within groups (family of curves) are probably related to changes in preload rather than to changes in regional contractility. Downward depression of the regional stress-velocity relations in group 2 is caused by depressed myocardial contractility.
authors.affiliation: Division of Cardiology, University Hospital, Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Büchi
authors.forename: O M
authors.initials: OM
authors.lastname: Hess
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: H P
authors.initials: HP
authors.lastname: Krayenbuehl
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012016:Reference Values; D013314:Stress, Mechanical; D013997:Time Factors