A novel lanosterol isomer produced in response to azole antifungals.
Gas chromatography-mass spectrometry has revealed the existence of a novel lanosterol-like sterol which is produced by fungi in response to treatment with azole drugs. The significance of this finding may be related to the changes in fungal sterol synthesis as a consequence to prolonged exposure to azoles and consequent development of resistance to these agents.
Howell
S A
SA
Institute of Dermatology, UMDS, St Thomas' Hospital, London, England.
Mallet
A I
AI
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D007536:Isomerism; D007810:Lanosterol / Q000096:biosynthesis* / Q000302:isolation & purification; D013261:Sterols / Q000096:biosynthesis* / Q000302:isolation & purification
D000935:Antifungal Agents; D001393:Azoles; D013261:Sterols; D007810:Lanosterol