title: Human leptospirosis in a slum area in the city of Rio de Janeiro, Brazil--a serological and epidemiological study.
abstract: A serologic survey was carried out on slum dwellers in the city of Rio de Janeiro. A total of 259 serum samples from male and female individuals of different age groups were tested for the presence of antileptospire antibodies by microagglutination. Prevalence data were analyzed in relation to the major risk factors present at the site, mainly represented by the presence of carrier animals and the occurrence of frequent floods. Of the samples tested, 25% reacted with antigens of different serogroups at titres ranging from 1:100 to 1:6400, with a predominance of titres less than or equal to 1:400; 35% of positive sera reacted with leptospirae of the Icterohaemorrhagiae serogroup. Reactions with Djasiman, Panama, Javanica, Canicola, Pyrogenes, Australis, Ballum, Sejroe, Bataviae, Grippotyphosa, Autumnalis and Cynopteri were also detected, though at lower frequencies. There was no statistically significant difference between sexes, but higher prevalence rates were found to be associated with increasing age. A focus of infection was characterized, in which social and economic factors contribute to the persistence of leptospirae by favoring the proliferation of the main reservoir.
authors.affiliation: Instituto Oswaldo Cruz, Departamento de Bacteriologia, Rio de Janeiro, RJ, Brasil.
authors.forename: M M
authors.initials: MM
authors.lastname: Pereira
authors.forename: J
authors.initials: J
authors.lastname: Andrade
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007919:Leptospira / Q000276:immunology*; D007921:Leptospira interrogans / Q000276:immunology; D007922:Leptospirosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011204:Poverty Areas; D051381:Rats; D016036:Seroepidemiologic Studies; D013552:Swine; D014895:Weil Disease / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial