The influences of dexamethasone and indomethacin on 67Ga uptake by normal tissues.
Dexamethasone (DEX) increased 67Ga uptake by the liver and spleen at 4, 8, and even 24 h after the injection of 67Ga. These results showed that DEX influenced 67Ga accumulation as well as the initial entry of 67Ga in the liver and spleen. On the other hand, indomethacin (IM) decreased 67Ga uptake by the liver and spleen at 4 h after the injection of 67Ga but did not influence the uptake at 8 or 24 h after the injection of 67Ga. Moreover, DEX or IM little influenced 67Ga uptake by the kidney and muscle. These results suggest that the influence of DEX or IM on 67Ga uptake or accumulation is specific for the liver and spleen.
Ohkubo
Y
Y
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
Satake
H
H
Koga
H
H
Katoh
S
S
Sasayama
A
A
Kohno
H
H
Kubodera
A
A
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics*; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013268:Stimulation, Chemical
D005710:Gallium Radioisotopes; D003907:Dexamethasone; D007213:Indomethacin