The effect of phenobarbital on the impairment of drug metabolism by carrageenan-induced inflammation in male rat.
Treatment of male rats with phenobarbital markedly stimulated, the activity of the hepatic microsomal monooxygenase system while in rats bearing carrageenan-induced inflammation the activity of this system was lowered. When both agents were administered together, the stimulatory effect of phenobarbital and the inhibitory effect of carrageenan-induced inflammation cancelled each other.
Sasaki
K
K
Department of Pharmacology & Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ishikawa
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002351:Carrageenan; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006591:Hexobarbital / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002351:Carrageenan; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D010634:Phenobarbital