title: [Clinico-hematological evaluation of 57 patients undergoing antiaggregant treatment with indobufen].
abstract: A long-term administration of Indobufen, 400 mg daily, was evaluated in 57 patients with cardiovascular diseases. Aggregation waves induced by ADP, collagen and epinephrine showed a significant and persistent inhibition of platelet function. Minor side effects were observed and in 6 patients the drug was withdrawn: 4 patients began to experience gastric troubles, 1 patient had positive occult test for blood, 1 patient developed an allergic rush. Clinical evaluation and platelet aggregation study before starting indobufen and during the follow up period seem to be useful in the evaluation of effectiveness, safety, compliance and suitable daily dose.
authors.affiliation: Ospedale San Giacomo, USL RM 1, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Andriani
authors.forename: G
authors.initials: G
authors.lastname: Mosiello
authors.forename: M G
authors.initials: MG
authors.lastname: Chiappetta
authors.forename: G
authors.initials: G
authors.lastname: Gregori
authors.forename: P
authors.initials: P
authors.lastname: Rinaldi
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; C020371:indobufen
vernacular_title: Valutazione clinico-ematologica di 57 pazienti in trattamento antiaggregante con indobufene.