[Nuclear DNA content in the cells of squamous cell carcinoma and Bowen's disease. I. Relationship between nuclear DNA content and grade of clinical and histological malignancy].
Nuclear DNA content of squamous cell carcinoma (SCC) was assayed by use of microfluorometry in an attempt to know the relationship between the content and grade of malignancy. As the results, we found that polyploid cell (greater than 4C) population tends to increase with advancing histological malignancy. However, the population of polyploid cells of grade 1, 2 and 3 SCC was almost the same. The number of polyploid cell of recurred lesion of SCC was increased than that of primary lesion. And polyploid cell (greater than GC) population in the primary lesion of the recurred case was higher than that in the tumor of non-recurred case. From these findings, it may be concluded that the polyploid cell population in SCC was proportional to clinical and histopathological malignancy in some extend.
Toyoshima
H
H
Department of Dermatology, Nagasaki University School of Medicine.
D000368:Aged; D000369:Aged, 80 and over; D001913:Bowen's Disease / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D011123:Polyploidy; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology
D004273:DNA, Neoplasm