title: Neisseria mucosa endocarditis.
abstract: A case of Neisseria mucosa tricuspid valve endocarditis in an intravenous drug abuser is described. The patient was treated initially with intravenous penicillin G followed by oral penicillin VK but relapsed. He was cured after 4 weeks of combined therapy with penicillin G and gentamicin. In vitro synergy studies performed on the patient's and two other isolates revealed synergy in all three. Thus, combination therapy is recommended for treatment of recalcitrant cases of bacterial endocarditis caused by N. mucosa.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
authors.forename: A E
authors.initials: AE
authors.lastname: Bacon
authors.forename: P G
authors.initials: PG
authors.lastname: Pal
authors.forename: D R
authors.initials: DR
authors.lastname: Schaberg
mesh_terms: D000328:Adult; D000668:Ampicillin Resistance; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009343:Neisseria / Q000187:drug effects / Q000302:isolation & purification*; D010400:Penicillin G / Q000494:pharmacology / Q000627:therapeutic use*; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D005839:Gentamicins; D010400:Penicillin G