[The effect of mepacrine and propranolol on lipid level in the alveolar surfactant during anaphylactic shock].
It is shown that the development of anaphylactoid shock in rats is connected with a decrease of the surface activity of alveolar surfactant and liberation of arachidonic acid from pulmonary surfactant phospholipids. Preventive injection of lipomodulators--A2 phospholipase inhibitor (mepacrine) or triglycecolipase inhibitor (propranolol)--to animals normalizes the level of lipids in the surfactant and blocks liberation of arachidonate and palmitate from surfactant phospholipids in an anaphylactoid shock.
Bashmakov
Iu K
IuK
Briuzgina
T S
TS
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000187:drug effects / Q000378:metabolism*; D011796:Quinacrine / Q000494:pharmacology*; D051381:Rats
D005227:Fatty Acids; D010743:Phospholipids; D011663:Pulmonary Surfactants; D011433:Propranolol; D011796:Quinacrine
Vliianie mepakrina i propranolola na soderzhanie lipidov v al'veoliarnom surfaktante pri anafilaktoidnom shoke.