Familial tetralogy of Fallot and glaucoma.
All 3 daughters of a mother with glaucoma had a conotruncal abnormality of the heart and glaucoma. The presence of heart and eye anomaly may be coincidental; however, both may be related to abnormal development of neural crest. The pedigree suggests autosomal dominant inheritance in this family.
Chen
S C
SC
Department of Pediatrics, St. Louis University School of Medicine, Missouri.
D'Souza
N
N
D000328:Adult; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D005901:Glaucoma / Q000150:complications / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D010375:Pedigree; D013771:Tetralogy of Fallot / Q000150:complications / Q000235:genetics*