[BCG-induced inflammation during childhood and in pregnancy. Additionally a contribution to BCG-induced necrotising cerebral arteritis].
In the third year of life of a girl vaccinated neonatally against tuberculosis an abscess of the associated lymph nodes appeared which contained acid-fast bacilli. After extirpation of the lymph nodes weeks later an intestinal BCG-dissemination was observed which seemed to be cured under a brief tuberculostatic therapy. At the age of 22 years a left sided hemiplegia due to aneurysms and thrombosis of 2 cerebral arteries was seen. At autopsy in the adventitia of the arteria basilaris macrophages were discovered which showed intracellular acid-fast bacilli. A paralysis of the oculomotor nerve appearing later was also caused by this brain lesion. Towards the end of a pregnancy a serious BCG-dissemination in the intestines relapsed. A healthy premature child was born. Massive tuberculostatic therapy was inefficient. The woman died in her 27th year of life. A defective function of the macrophages is suggested for the immunological abnormality.
Ehrengut
W
W
Institut für Impfwesen und Virologie, Hamburg.
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001167:Arteritis / Q000209:etiology; D001500:BCG Vaccine / Q000009:adverse effects*; D002536:Cerebral Arteries; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D014385:Tuberculosis, Gastrointestinal / Q000150:complications* / Q000188:drug therapy; D014388:Tuberculosis, Lymph Node / Q000209:etiology* / Q000382:microbiology / Q000601:surgery
D000995:Antitubercular Agents; D001500:BCG Vaccine
BCG-itis während der Kindheit und in der Schwangerschaft. Zugleich ein Beitrag zu einer BCG-bedingten nekrotisierenden zerebralen Arteriitis.