Soluble interleukin 2 receptor and tissue polypeptide antigen serum concentrations in end-stage renal failure.
Serum concentrations of soluble interleukin 2 receptor (IL-2R) were measured in 65 hemodialysis patients and compared with serum levels of beta 2-microglobulin and tissue polypeptide antigen (TPA). Elevated IL-2R levels, found in 85% of examined patients, correlated with elevated TPA serum concentrations (p less than 0.05). Patients with high IL-2R levels were significantly younger (p less than 0.05) than patients with low levels. Primary renal disease and residual renal function had no significant influence on TPA or IL-2R serum concentrations. In 16 patients with carpal tunnel syndrome, increased serum concentrations of IL-2R (p less than 0.005) and TPA (p less than 0.001) were found. We conclude that a non-specific dialysis-induced activation of epithelial and lymphoid cells rather than a specific immune response could explain the concomitant elevation of IL-2R and TPA serum concentrations in hemodialyzed patients. Patients with pronounced cell turnover, reflected by elevated IL-2R and TPA levels, may show an increased susceptibility to dialysis-associated amyloidosis.
Walz
G
G
Medizinische Abteilung, Freie Universität, Berlin.
Kunzendorf
U
U
Josimovic-Alasevic
O
O
Preuschoff
L
L
Schwarz
A
A
Keller
F
F
Asmus
G
G
Offermann
G
G
Diamantstein
T
T
Distler
A
A
D000368:Aged; D000686:Amyloidosis / Q000209:etiology; D000941:Antigens / Q000097:blood; D002349:Carpal Tunnel Syndrome / Q000097:blood / Q000209:etiology / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects; D012995:Solubility; D019396:Tissue Polypeptide Antigen; D001613:beta 2-Microglobulin / Q000378:metabolism
D000941:Antigens; D010455:Peptides; D015375:Receptors, Interleukin-2; D019396:Tissue Polypeptide Antigen; D001613:beta 2-Microglobulin