[The immunological properties of the main outer membrane protein of Legionella].
The immunogenic properties of Legionella outer membrane main protein (OMMP) were studied by its effect on the proliferative activity of lymphocytes in guinea pigs. Preliminary immunization with OMMP activated only the specific and nonspecific proliferation of spleen cells. After infection with Legionella, secondary immune response developed in the spleen and lungs of previously immunized animals, in contrast to intact ones, and the nonspecific proliferative activity of lymphocytes in the spleen and lungs of previously immunized animals considerably increased. These results are indicative of the fact that Legionella OMMP, similarly to other Legionella antigens and immunomodulators, may be used for the formation of protective immunity.
Zubashev
I K
IK
Pronin
A V
AV
Tartakovskiĭ
I S
IS
Rodionov
A V
AV
Koniukhov
V F
VF
Petrosov
V V
VV
Dmitriev
B A
BA
Molokova
E V
EV
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002455:Cell Division / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D007875:Legionella / Q000276:immunology* / Q000472:pathogenicity; D007877:Legionnaires' Disease / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000276:immunology; D012692:Serial Passage; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014774:Virulence / Q000276:immunology
D001425:Bacterial Outer Membrane Proteins
Immunologicheskie svoĭstva glavnogo belka vneshneĭ membrany legionell.