title: Susceptibility of Mongolian gerbils (Meriones unguiculatus) to leptospires and the protective effect of vaccination.
abstract: Mongolian gerbils, Meriones unguiculatus, were shown to be highly susceptible to Leptospira interrogans serovars such as icterohaemorrhagiae, copenhageni, canicola, autumnalis, javanica, pyrogenes and hebdomadis as compared to guinea pigs and hamsters. Mortality with signs of haemorrhage and jaundice was recorded in all experimental rodents after intraperitoneal inoculation with all strains of the serovars indicated. However, Mongolian gerbils were comparatively susceptible to strains which were of low virulence to guinea pigs and hamsters. Use of leptospiral vaccination proved effective in protecting the animals against inoculum challenges. The Mongolian gerbil is a species that may be selectively and preferentially useful for assays on the protective effects of leptospiral vaccination.
authors.affiliation: Laboratory of Biomedical Science, College of Agriculture and Veterinary Medicine, Nihon University, Fujisawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yukawa
authors.forename: K
authors.initials: K
authors.lastname: Mochizuki
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D015169:Colony Count, Microbial; D006224:Cricetinae; D004198:Disease Susceptibility; D005849:Gerbillinae; D006168:Guinea Pigs; D007919:Leptospira / Q000254:growth & development / Q000276:immunology*; D007922:Leptospirosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D012376:Rodent Diseases / Q000276:immunology* / Q000517:prevention & control
chemical_list: D001428:Bacterial Vaccines