Pediatric brainstem glioma. Post-radiation clinical and MR follow-up.
Thirty-four pediatric patients, twenty with presumed and fourteen with biopsy or autopsy proven brainstem gliomas were imaged by CT and MR before radiation therapy. Twenty-eight patients received radiotherapy. Of these, eighteen fit the protocol for combined clinical and MR post-treatment evaluation. No cases of radionecrosis were seen at autopsy. This study shows that MR can demonstrate tumor response to radiation therapy, tumor progression prior to clinical deterioration, post-treatment cyst formation and hemorrhage. Although MR clinical correlation was not optimal on six week post-treatment evaluation, 4-10 month post-treatment MR scanning correlated well with clinical evaluation. MR appears useful in post-therapeutic monitoring of tumor response.
Smith
R R
RR
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia.
Zimmerman
R A
RA
Packer
R J
RJ
Hackney
D B
DB
Bilaniuk
L T
LT
Sutton
L N
LN
Goldberg
H I
HI
Grossman
R I
RI
Schut
L
L
D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D001933:Brain Stem; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects; D003560:Cysts / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests