[The effect of antidepressants on the experimental anticonvulsant activity and acute toxicity of anticonvulsants].
In the experiments on white mice there was studied the anticonvulsant activity by the test of the maximal electric shock and acute toxicity of anticonvulsants and antidepressants at separate and combined administration. The combined use of anticonvulsants and antidepressants showed the increase of the anticonvulsant activity of phenobarbital with amitriptyline, levomepromazine and lithium oxybutyrate; diphenine and carbamazepine with amitriptyline as well as hexamidine with all antidepressants. The combination of phenobarbital with amitriptyline, levomepromazine and lithium oxybutyrate, diphenine with amitriptyline, hexamidine with amitriptyline and imizine proved to be the safest.
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D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use* / Q000633:toxicity; D000928:Antidepressive Agents / Q000627:therapeutic use* / Q000633:toxicity; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004597:Electroshock; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D000928:Antidepressive Agents
Vliianie antidepressantov na protivosudorozhniu aktivnost' i ostruiu toksichnost' antikonvul'santov v éksperimente.