[Increase of serum acidic isoferritins in patients with hemophagocytic histiocytosis].
We investigated serum isoferritin patterns in 2 patients with reactive hemophagocytic histiocytosis (HH) and 1 patient with neoplastic HH (malignant histiocytosis) whose serum ferritin levels were extraordinarily high. Serum ferritins in 2 patients with reactive HH were composed of mildly (pI 5.55 to 5.10) to intermediately (pI 4.81 to 4.82) acidic isoferritins, while those in patient with neoplastic HH were composed of more acidic (pI 4.70 to 4.45) isoferritins. These results indicate that the main constituents of the increased serum ferritins in HH would be acidic isoferritins, and that more acidic isoferritins would be increased in neoplastic HH than reactive HH.
Shimmyozu
K
K
Third Department of Internal Medicine, School of Medicine, Kagoshima University.
Kadokura
N
N
Itoyama
T
T
Tara
M
M
Maruyama
I
I
Osame
M
M
D000328:Adult; D005293:Ferritins / Q000097:blood*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
C020391:acidic isoferritin; D005293:Ferritins