Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms.
Concentrations of three anti-infective agents in tear film were monitored after one topical application in rabbits. Ofloxacin concentrations exceeded the MIC for 90% of the organisms tested (MIC90) (gram-negative and gram-positive organisms) for 240 min. Tobramycin concentrations exceeded the MIC90 for 10 min. Gentamicin concentrations exceeded the MIC90 for 20 min for gram-positive organisms and 120 min for gram-negative organisms.
Richman
J
J
Allergan Pharmaceuticals, Irvine, California 92715.
Zolezio
H
H
Tang-Liu
D
D
D000818:Animals; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000494:pharmacology; D011817:Rabbits; D011863:Radioimmunoassay; D013050:Spectrometry, Fluorescence; D013666:Tears / Q000378:metabolism*; D014031:Tobramycin / Q000493:pharmacokinetics* / Q000494:pharmacology
D005839:Gentamicins; D015242:Ofloxacin; D014031:Tobramycin