Chemical carcinogenesis: too many rodent carcinogens.
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. We conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.
Ames
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BN
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
Gold
L S
LS
D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens; D002455:Cell Division; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D008934:Mitogens; D009152:Mutagenicity Tests; D009154:Mutation; D009369:Neoplasms / Q000209:etiology; D051381:Rats; D012307:Risk Factors
D002273:Carcinogens; D008934:Mitogens