title: [Gastritis: immunohistochemical detection of specific and nonspecific immune response to Helicobacter pylori].
abstract: Granulocyte infiltration was studied in 88 biopsies of antrum mucosa from patients with B-gastritis. Evidence of IgA-, IgG- and IgM-antibodies as well as of lysozyme in the mucosa was demonstrated by immunohistochemical methods. Helicobacter pylori (Hp) is coated by antibodies and a significant correlation between extent of opsonisation and number of plasma cells in the connective tissue of the lamina propria could be stated. Thus, the infiltration of plasma cells is a specific immune response against Hp. In the depths of gastric pits the antibody-coating of bacteria is faint. Instead, lysozyme and lactoferrin are produced there. By means of a Cross-sectional study a model is developed which characterizes B-gastritis as a dynamic process. Lagging behind, the inflammation follows the motile bacteria resulting in a patchy distribution of inflamed areas in the mucosa. At the peak of these local inflammation-waves the production of antibodies and lysozyme is intensified. Coating the bacteria with IgG and IgM results in complement activation liberating chemotaxin C5a. Consequently, there is a massive granulocyte infiltration leading to local reduction or eradication of Hp.
authors.affiliation: Pathologisches Institut, Universität Erlangen-Nürnberg.
authors.forename: C
authors.initials: C
authors.lastname: Mollenkopf
authors.forename: H
authors.initials: H
authors.lastname: Steininger
authors.forename: G
authors.initials: G
authors.lastname: Weineck
authors.forename: M
authors.initials: M
authors.lastname: Meyer
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D000918:Antibody Specificity / Q000276:immunology*; D001706:Biopsy; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000473:pathology; D016481:Helicobacter Infections / Q000276:immunology* / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D009113:Muramidase / Q000032:analysis
chemical_list: D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D009113:Muramidase
vernacular_title: Gastritis: Immunhistochemischer Nachweis der spezifischen und unspezifischen Immunabwehr gegen Helicobacter pylori.