Effects of anesthesia on efferent phrenic activity in neonatal swine.
The effects of two levels of Saffan anesthesia (standard recording level: 2-4 mg/kg/min, and 10X recording level) and a single level of pentobarbital (5 mg/kg) on the power spectral density of efferent phrenic discharge were investigated in piglets aged from less than 1 day to 50 days. The phrenic high frequency oscillation (HFO) was present in decerebrate, unanesthetized piglets and in piglets anesthetized with Saffan, albeit reduced at 10 times recording level, but was absent under pentobarbital. The results indicate that Saffan does not have a significantly depressant effect on the phrenic HFO in developing swine.
Gootman
P M
PM
Department of Physiology, SUNY-Health Science Center, Brooklyn 11203.
Cohen
H L
HL
Steele
A M
AM
Sica
A L
AL
Condemi
G
G
Gandhi
M R
MR
Eberle
L P
LP
D000530:Alfaxalone Alfadolone Mixture; D000758:Anesthesia; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D003655:Decerebrate State; D004562:Electrocardiography; D006221:Halothane; D007649:Ketamine; D009476:Neurons, Efferent / Q000187:drug effects* / Q000502:physiology; D009609:Nitrous Oxide; D010424:Pentobarbital / Q000494:pharmacology; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology*; D013552:Swine
D007649:Ketamine; D000530:Alfaxalone Alfadolone Mixture; D010424:Pentobarbital; D009609:Nitrous Oxide; D006221:Halothane