title: [Clinical significance of Tl-201/Tc-99m subtraction scintigraphy as a parameter for surgical indication of cold struma nodules].
abstract: In a retrospective study Tl-201/Tc-99m subtraction scintigraphy (method acco. to Ferlin et al.) was performed in addition to Tc-99m scintigraphy, sonography and fine needle puncture in 400 patients. Postoperative histological evidence was available of all patients (carcinomas [n = 31], follicular and oncocytic adenomas [n = 235], nodular hyperplasia, Hashimoto's thyroiditis, Riedel's struma and de Quervain's thyroiditis [n = 134]). With regard to possible malignancy the sensitivity, in case of positive Tl-201 uptake was 85%. As however, adenomas also have a high tendency towards isolated Tl-201 uptake, the specificity for malignant growth was 62%. Thus Tl-201/Tc-99m subtraction scintigraphy is well suited as a criterion to exclude thyroid carcinomas; on the other hand, a positive Tl-201 uptake is not a fail-safe indication of malignant processes. At best it suggests the occurrence of autonomous growth and can thus, in addition to sonography and fine needle biopsy, serve as an aid in the decision as to whether surgical intervention is indicated.
authors.affiliation: Krankenhaus der Barmherzigen Brüder, Graz-Eggenberg.
authors.forename: G
authors.initials: G
authors.lastname: Binter
authors.forename: P
authors.initials: P
authors.lastname: Lind
authors.forename: W
authors.initials: W
authors.lastname: Langsteger
authors.forename: G
authors.initials: G
authors.lastname: Klima
authors.forename: P
authors.initials: P
authors.lastname: Költringer
authors.forename: A
authors.initials: A
authors.lastname: Beham
authors.forename: O
authors.initials: O
authors.lastname: Eber
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006044:Goiter, Nodular / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013382:Subtraction Technique; D013667:Technetium; D013794:Thallium Radioisotopes; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D013966:Thyroiditis / Q000000981:diagnostic imaging
chemical_list: D013794:Thallium Radioisotopes; D013667:Technetium
vernacular_title: Klinische Bedeutung der Tl-201/Tc-99m-Subtraktionsszintigraphie als Parameter für die Operationsindikation kalter Strumaknoten.