[Cytogenetic effects of attenuated live measles vaccine on male mice].
The cytogenetic effects of attenuated live measles vaccine on somatic and germinal cells of C57BL/6J mice were studied. The frequencies of micronuclei of polychromatic erythrocytes, nucleated cells, chromatid breaks, fragments in bone marrow cells, and micronuclei of spermatids in testes were increased, which have dose- and time-dependent relationship. However, there were no statistical difference between the treated and control mice in chromosomal breaks and fragments of spermatogonia primary and secondary spermatocytes. The results and their possible biological significance were also discussed.
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Kunming Institute of Zoology, Academia Sinica, Yunnan.
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D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D008297:Male; D008458:Measles Vaccine / Q000009:adverse effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D013094:Spermatozoa / Q000473:pathology; D014613:Vaccines, Attenuated / Q000009:adverse effects
D008458:Measles Vaccine; D014613:Vaccines, Attenuated