title: The effect of mycophenolic acid on the cell cycle of Candida albicans.
abstract: Mycophenolic acid inhibited the growth of Candida albicans. Cultures exposed to a concentration of 8.4 micrograms ml-1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.
authors.affiliation: Biology Department, Maynooth College, Ireland.
authors.forename: C M
authors.initials: CM
authors.lastname: Quinn
authors.forename: V C
authors.initials: VC
authors.lastname: Bugeja
authors.forename: J A
authors.initials: JA
authors.lastname: Gallagher
authors.forename: P A
authors.initials: PA
authors.lastname: Whittaker
mesh_terms: D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D002453:Cell Cycle / Q000187:drug effects*; D015169:Colony Count, Microbial; D009173:Mycophenolic Acid / Q000494:pharmacology*
chemical_list: D009173:Mycophenolic Acid