"CORT-EX:" a program for quantitative analysis of brain SPECT data.
A program was developed to extract from brain SPECT data global as well as regional concentrations of a radiopharmaceutical while allowing for improved subjective evaluation of its distribution. This program was used to process the data obtained from 17 normal subjects, 20 min, 2 hr, and 4 hr after the injection of iodine-labeled iodoamphetamines. The mean absolute cortical uptake at these three time periods was 0.921 (+/- 0.185), 0.803 (+/- 0.107), and 0.748 (+/- 0.103) in arbitrary units (+/- s.d.), respectively. The regional distribution of the tracer became more uniform with time due to an uneven washout rate. The cerebellum was noted to have a very high variability in its uptake and a high washout rate, making it unsuitable as an internal standard for relative quantification. Finally, a repeat study was performed on 10 subjects. No significant difference could be demonstrated in the mean uptake of the group at 2 and 4 hr, however the difference observed in the 20 min uptake values was significant at the p = 0.05 level.
Lamoureux
G
G
Département de Médecine Nucléaire et Radiobiologie, Université de Sherbrooke, Québec, Canada.
Dupont
R M
RM
Ashburn
W L
WL
Halpern
S E
SE
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D003627:Data Interpretation, Statistical; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000706:statistics & numerical data*