[Spectral-fluorescent characteristics of rat transcortin in normal conditions and during experimental circulatory insufficiency].
Spectral-fluorescent parameters of rat transcortin isolated from blood plasma of intact rats and rats with circulatory insufficiency were studied. The differences in the Schtern Folmer constants and the dissociation constants for the transcortin-corticosterone complex obtained during the protein titration by corticosterone may be due to different tryptophanyl surroundings in the molecules of the studied proteins. This may be a consequence of the conformational rearrangements of the corticosteroid-binding globulin molecules.
Nadol'nik
L I
LI
Chaĭkovskaia
N A
NA
Beluga
V B
VB
Vinogradov
V V
VV
D000818:Animals; D002850:Chromatography, Gel; D003345:Corticosterone / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D051381:Rats; D013050:Spectrometry, Fluorescence; D014156:Transcortin / Q000737:chemistry*; D014364:Tryptophan; D014652:Vascular Diseases / Q000097:blood*
D014364:Tryptophan; D014156:Transcortin; D003345:Corticosterone
Spektral'no-fluorestsentnye kharakteristiki transkortina krys v norme i pri éksperimental'noĭ nedostatochnosti krovoobrashcheniia.