Attenuation of effects of phenylethylamine on social and individual behaviour in mice by ethanol pretreatment.
Beta-phenylethylamine (PEA, 10 mg/kg, intraperitoneally) exerts the following behavioural effects in mice: (1) a decrease in the rate and duration of contacts (sniffings), typical of anxiogens, in albino SHR (bred from Swiss) male mice and a decrease in the duration of contacts in C57l/6 mice; (2) a decrease in the duration of grooming in both strains; (3) an increase in locomotion and rearings in long-sleeping C57Bl/6 mice. Pretreatment with ethanol (100 mg/kg, orally) diminished these effects of PEA. It is suggested that the anxiolytic action of ethanol may be related to its antagonism of PEA.
Mutovkina
L G
LG
Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, Leningrad, U.S.S.R.
Lapin
I P
IP
D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D006120:Grooming / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D010627:Phenethylamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012919:Social Behavior; D013045:Species Specificity
D010627:Phenethylamines; C029261:phenethylamine; D000431:Ethanol