Radioimmunoscintigraphy using iodine-131-anti-CEA monoclonal antibodies and thallium-201 scintigraphy in medullary thyroid carcinoma: a case report.
This case report demonstrates the use of thallium-201 (201Tl) scans versus iodine-131- (131l) anti-CEA F(ab')2 scans in a patient with high serum CEA levels due to metastases of medullary thyroid carcinoma in the suprarenal region and sacroiliacal region. Scintigraphy using monoclonal antibodies directed against CEA showed a higher tumor uptake (0.26% dose and 0.64% dose, respectively) than a thallium scan and is believed to be promising for future radiotherapeutic applications.
Zanin
D E
DE
Department of Nuclear Medicine, Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam.
van Dongen
A
A
Hoefnagel
C A
CA
Bruning
P F
PF
D000328:Adult; D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000276:immunology*; D002277:Carcinoma / Q000097:blood / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes; D013964:Thyroid Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes; D013794:Thallium Radioisotopes