title: [Lysosomal hydrolases of various rat organs in the process of cell nutrition].
abstract: Activity of lysosomal proteinases cathepsins A, B, C, D, H and L was studied in liver, kidney, spleen, thymus, heart, skeletal muscle and brain tissues of rats, maintained on full value diet, on a diet free of proteins and on the diet enriched with methionine. Distinctly dissimilar reactions of thiol-dependent proteinases was detected in liver, heart tissues and skeletal muscles as compared with the reaction of cathepsins A and D; activity of cathepsins B, H and L was decreased 1.5-2-fold in the animal groups maintained on diets both free of proteins and enriched with methionine. The data obtained suggest that concentration of endogenous inhibitors of lysosomal thiol-dependent proteinases rather than content of SH-groups in tissues was responsible for alterations of their activity under conditions of protein starvation.
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
authors.forename: N S
authors.initials: NS
authors.lastname: Bregvadze
authors.forename: V A
authors.initials: VA
authors.lastname: Tutel'ian
mesh_terms: D000818:Animals; D006867:Hydrolases / Q000378:metabolism*; D006868:Hydrolysis; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D009928:Organ Specificity; D011488:Protein Deficiency / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D013438:Sulfhydryl Compounds; D008715:Methionine; D006867:Hydrolases
vernacular_title: Lizosomal'nye gidrolazy razlichnykh organov krys v protsessakh kletochnogo pitaniia.