[Trimetazidine and degenerative deafness. Effect on hearing and integration].
This study was conducted in order to assess the activity of trimetazidine dosed at 60 mg/day in patients presenting degenerative loss of hearing. Ten centers participated in this multicenter double-blind placebo-controlled trial which spanned 6 months. Included were 251 patients (118 women, 133 men) presenting with pure perception bilateral symmetrical deafness concerning predominantly the acute frequency range. 228 patients terminated the study, including 115 in the trimetazidine group and 113 in the placebo group. The evolution over a 6-month treatment period was significantly better with trimetazidine as regards the following parameters: audibility as assessed by pure-tone audiometry, namely at the acute frequency range (p = 0.002), intelligibility as assessed by speech audiometry (p = 0.008), subjective evaluation of hearing loss and its impact on the patient's social life. Results confirm the value of trimetazidine hearing loss management, based on clinical, subjective criteria as well as audiometric ones. Parameters reflecting best trimetazidine's efficacy were intelligibility and the psychological/behavioral impact of the impairment, allowing for better social integration of the subject.
Haguenauer
J P
JP
Service d'Oto-Rhino-Laryngologie, Hôpital de la Croix-Rousse, Lyon.
Bebear
J P
JP
Bordes
L R
LR
Jacquot
M
M
Mercier
J
J
Morgon
A
A
Pech
A
A
Romanet
P
P
Thomassin
J M
JM
Wayoff
M
M
D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry; D004311:Double-Blind Method; D005260:Female; D006309:Hearing / Q000187:drug effects*; D034381:Hearing Loss / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011897:Random Allocation; D013067:Speech Perception / Q000187:drug effects; D013997:Time Factors; D014292:Trimetazidine / Q000627:therapeutic use*
D010919:Placebos; D014292:Trimetazidine
Trimétazidine et surdités dégénératives. Effets sur l'audition et l'intégration.