[The effect of tefestrol on the secretion of luteinizing hormone from the hypophysis].
The effect of tefestrol on the content of luteinising hormone in blood and hypophysis in female and male rats was studied on the basis of the radioimmunological assays. It was shown that administration of tefestrol to the female rats depending on the preparation dose and the time of administration during the estrous cycle can produce an increase and a decrease of luteinising hormone content in the material under study. In the male rats tefestrol induced a stable elevation of blood gonadotropine level. The results obtained suggest that tefestrol may be used as a stimulant of the reproductive function and also as a contraceptive depending on the dose and the functional state of the reproductive system during the treatment.
Ignatkov
V Ia
VIa
Akhmedkhodzhaeva
Kh S
KhS
Babichev
V N
VN
D000818:Animals; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D005309:Ferula; D007986:Luteinizing Hormone / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010947:Plants, Toxic; D051381:Rats; D013997:Time Factors
D010936:Plant Extracts; C066296:tefestrol; D007986:Luteinizing Hormone
Vliianie teféstrola na sekretsiiu liuteiniziruiushchego gormona iz gipofiza.