Recent developments in the biosynthesis of the tropane alkaloids.
Recent work on the biosynthesis of the tropane moiety of cocaine, hyoscamine, scopolamine, and related alkaloids is reviewed. Revision of the generally accepted biosynthetic pathway to these alkaloids is now proposed in the light of new discoveries. New information on the biosynthesis of some of the acid moieties (benzoic, tiglic and tropic acid) of the tropane ester alkaloids is also discussed.
Leete
E
E
Department of Chemistry, University of Minnesota, Minneapolis 55455.
D000143:Acids / Q000378:metabolism; D001285:Atropine / Q000378:metabolism; D004952:Esters; D015394:Molecular Structure; D010944:Plants / Q000378:metabolism*; D011758:Pyrroles / Q000378:metabolism; D012196:Review Literature as Topic; D012601:Scopolamine / Q000378:metabolism; D014326:Tropanes / Q000378:metabolism*
D000143:Acids; D004952:Esters; D011758:Pyrroles; D014326:Tropanes; C066184:1-methyl-delta(1)-pyrrolinium; C016808:3-tropinone; D001285:Atropine; D012601:Scopolamine