title: Can the chronobiological approach better evaluate the relationship between diabetes mellitus and arterial hypertension?
abstract: This work evaluates by a chronobiological approach the relationship between arterial hypertension and diabetes mellitus. Sixteen type II (non-insulin-dependent) diabetic hypertensive males (age 50-60 years, BMI 26 +/- 1, without nephropathy) were selected for the study. Blood pressure (BP) was considered borderline, mild or moderate, systolic and/or diastolic by a single measurement (occasional measurement) according to the Report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (1984). Then both dynamic ambulatory BP through a 24-hr span (5300 ABPS Spacelabs) and an oral glucose-tolerance test (100 gm) with serum glucose and insulin measures were carried out. Total insulin area (TIA) and total glucose area (TGA) were computed. Blood-pressure values were analyzed by the Cosinor method, and then percent time of elevation (PTE) and the hyperbaric impact (HBI) were calculated. A statistically significant positive correlation was found between TIA and the mesors of both systolic BP/diastolic BP (p less than 0.05) and HBI (p less than 0.05 and p less than 0.01, respectively).
authors.affiliation: Institute of Internal Medicine, University of Chieti, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Capani
authors.forename: S
authors.initials: S
authors.lastname: Basile
authors.forename: M T
authors.initials: MT
authors.lastname: Guagnano
authors.forename: L
authors.initials: L
authors.lastname: Ramoni
authors.forename: S
authors.initials: S
authors.lastname: Sensi
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002909:Chronobiology Phenomena / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
chemical_list: D007328:Insulin