title: Mechanisms of eosinophil accumulation around eggs of Schistosoma japonicum: role of two purified components, allergen and eosinophil chemotactic factor, from soluble egg antigens measured on sensitized guinea pig skin.
abstract: Mechanisms of eosinophil response induced by soluble egg antigen (SEA) in Schistosoma japonicum-infected guinea pig tissues were analyzed using two purified components of SEA: major allergenic components (JEAL) and a major eosinophil chemotactic component (ECF-SjE). Eosinophil response to the crude SEA of S. japonicum was detected at the injection site mainly at 2-8 h after the antigenic challenge; this response consisted of two different phases of eosinophil attraction. An early phase (2 h) was mediated by an immediate-type hypersensitivity reaction; JEAL played an important role in mediating this phase of eosinophil response. A late phase (8 h) was mediated by ECF-SjE. Therefore, this phase of eosinophil response was caused by direct eosinophilotactic activity of SEA. These two types of eosinophil response must be important processes in the formation of S. japonicum egg-associated eosinophilic granuloma.
authors.affiliation: Department of Medical Zoology, Nagasaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Horii
authors.forename: M
authors.initials: M
authors.lastname: Owhashi
authors.forename: A
authors.initials: A
authors.lastname: Ishii
mesh_terms: D000485:Allergens / Q000502:physiology; D000818:Animals; D000947:Antigens, Helminth / Q000502:physiology*; D002630:Chemotactic Factors / Q000502:physiology; D004804:Eosinophils / Q000502:physiology*; D006168:Guinea Pigs; D015801:Helminth Proteins; D007700:Kinetics; D008222:Lymphokines / Q000502:physiology; D010063:Ovum / Q000276:immunology / Q000502:physiology*; D012549:Schistosoma japonicum / Q000502:physiology*; D012867:Skin / Q000469:parasitology / Q000473:pathology; D012882:Skin Tests
chemical_list: D000485:Allergens; D000947:Antigens, Helminth; D002630:Chemotactic Factors; D015801:Helminth Proteins; D008222:Lymphokines; C022227:eosinophil stimulating promoter; C055560:p40 egg antigen, Schistosoma