[Heparin-histamine complex, its physico-chemical and biological properties].
Complexes between heparin and histamine at various ratio exhibited various physiological activity. The complex containing heparin-histamine at the ratio of 6:1, 10:1 or 15:1 showed anticoagulation, antipolymerization and nonenzymatic fibrinolytic effects. The complex dissociated in circulation within 90 min after its administration. This complex effected also the rheologic properties of blood.
Kudriashov
B A
BA
Liapina
L A
LA
Azieva
L D
LD
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000737:chemistry* / Q000494:pharmacology / Q000502:physiology; D006632:Histamine / Q000737:chemistry* / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D011108:Polymers; D051381:Rats
D046911:Macromolecular Substances; D011108:Polymers; D006632:Histamine; D006493:Heparin
Kompleksnoe soedinenie geparina s gistaminom, ego fiziko-khimicheskie i biologicheskie svoĭstva.