[Sulfur dioxide-induced bronchial constriction in asthmatics and its prophylaxis by salbutamol].
Patients with bronchial asthma often develop acute attack in kitchen while burning honeycomb briquet which is widely used for cooking in southern China. Burning of a honeycomb briquet produces 0.6-4.3 ppm sulphur dioxide (SO2) in the kitchen air. To assess whether the above concentration of SO2 can induce bronchial constriction, we performed SO2 bronchial provocation test on 21 asthmatics (male 11, female 10, average age 28.8 +/- 2.0 years), 10 patients with allergic rhinitis (male 3, female 7.28 +/- 1.6 years) and 20 healthy non-smokers (male 13, female 7, 28.1 +/- 1.5 years). FEV1 showed no significant change in both healthy and rhinitis group even a maximal amount of SO2 (10 ppm) was given. The calculated PC20 FEV1 and PC35 SGaW in asthmatics were 3.7 +/- 0.22 ppm and 2.5 +/- 0.18 ppm respectively, which fell into the SO2 range yielded by a burning honeycomb briquet. Orally administered slow release salbutamol created protective effect in 5 out of 8 patients. Salbutamol inhalation, however, completely blocked SO2 induced bronchial constriction. We suggest that patient with bronchial asthma should receive salbutamol aerosol inhalation before cooking with burning honeycomb briquet.
Luo
Z Y
ZY
Guangzhuo Institute of Respiratory Diseases.
Zheng
J P
JP
Luo
D F
DF
D000280:Administration, Inhalation; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests / Q000379:methods; D001986:Bronchial Spasm / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D013458:Sulfur Dioxide / Q000009:adverse effects*
D013458:Sulfur Dioxide; D000420:Albuterol