[Relation between localization of gastric mucosal lesions and microvascular disturbance].
Acute gastric mucosal lesions in the rats were produced by intermittent electrical stimuli to a main trunk of the left gastric artery (LGA), right gastroepiploic artery (RGEA) or a posterior branch of the left gastric artery (PLGA). The image processing analysis was applied to determine the relation between distribution of the lesions and perfusion area of the supplying artery to which electrical stimuli were given. Electrical stimuli of 50 Hz, 5 msec, 100 microA was supplied to the artery for 30 sc three times with 10 sec interval. A series of these stimuli was repeated three times. The mucosal blood flow measured with the laser doppler method in each perfusion area was reduced to less than 35% of the control value during the electrical stimuli for 30 sec. After the repeated electrical stimuli to LGA, 85.8 and 95.4% of the mucosal lesions were found in the mean and maximum perfusion area of LGA, respectively. Electrical stimuli to PLGA caused 84.5% and 95.3 of the lesions in the mean and maximum area of PLGA, respectively. Stimuli to RGEA caused 53.4% and 74.1% of the lesions in the mean and maximum perfusion area of RGEA. In the antrum, electrical stimuli to LGA, PLGA or RGEA produced 0%, 5.4% or 5.0% of the mucosal lesions. It is concluded that the corpus mucosal lesions induced by regional ischemia are distributed in the ischemic area.
Nagata
H
H
Department of Internal Medicine, Saiseikai Central Hospital.
Morishita
T
T
Minamitani
H
H
Suzuki
M
M
Suematsu
M
M
Miura
S
S
Houzawa
S
S
Oda
M
M
Tsuchiya
M
M
D000818:Animals; D004558:Electric Stimulation; D005753:Gastric Mucosa / Q000098:blood supply* / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains