title: Interaction of cimetidine with human serum albumin.
abstract: Ultrafiltration studies have detected the existence of a weak interaction between cimetidine and human serum albumin, a finding supported by corresponding studies with this xenobiotic and bovine serum albumin. Furthermore, the binding characteristics of the interaction with human serum albumin (4 sites, K = 630 M-1) more than suffice to account for the proportion of protein-bound drug in the serum of patients subjected to cimetidine therapy. Thus, although alpha 1-acid glycoprotein is usually regarded as the specific transporter of basic drugs, the present evidence implicates albumin as the likely binding protein for cimetidine in serum.
authors.affiliation: Department of Biochemistry, University of Queensland, St Lucia, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Wilson
authors.forename: M A
authors.initials: MA
authors.lastname: Bogoyevitch
authors.forename: D J
authors.initials: DJ
authors.lastname: Winzor
mesh_terms: D001665:Binding Sites; D002021:Buffers; D002927:Cimetidine / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D014462:Ultrafiltration
chemical_list: D002021:Buffers; D012709:Serum Albumin; D002927:Cimetidine