title: Synchronous Hodgkin's disease and myelofibrosis terminating with granulocytic sarcoma and acute megakaryocytic leukemia.
abstract: Our patient had stage IIIAI Hodgkin's disease with synchronous myelofibrosis and myeloid metaplasia. A slowly progressive myeloproliferative disease developed over 9 1/2 years and terminated in a painful osteolytic bone disease, spinal extradural granulocytic sarcoma and acute megakaryocytic leukemia. It is likely that this was a result of the myeloproliferative disease rather than a late complication from combination chemotherapy. Our case demonstrates the importance of a curative approach to Hodgkin's disease even in the face of a coexistent disease with a long or unknown natural history.
authors.affiliation: Hematology-Oncology Service, Walter Reed Army Medical Center, Washington, DC.
authors.forename: S J
authors.initials: SJ
authors.lastname: Vukelja
authors.forename: J
authors.initials: J
authors.lastname: Krishnan
authors.forename: F T
authors.initials: FT
authors.lastname: Ward
authors.forename: J
authors.initials: J
authors.lastname: Redmond
mesh_terms: D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology; D012509:Sarcoma / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000473:pathology*; D013997:Time Factors