Human intestinal tissue antibiotic concentrations. Clindamycin, gentamicin, and mezlocillin.
An antibiotic, to be effective for prophylaxis in abdominal trauma, should quickly achieve high concentrations in the intestinal wall and at enough inhibitory levels to kill most aerobic and anaerobic bacteria that are potential contaminants at the site of surgical incision. Therefore, we studied the intestinal tissue levels of clindamycin, gentamicin, and mezlocillin to see whether the tissue levels achieved by these antibiotics in the intestinal tissue were adequate. A single dose of mezlocillin, 4 grams; clindamycin, 600 mg and gentamicin, 80 mg; quickly reached the desired concentrations, i.e., 52.3, 9.69 and 6.1 micrograms/gram of intestinal tissue respectively. These levels were high enough to inhibit the growth of most isolates of E. coli and B. fragilis, common pathogens involved in intra-abdominal abscess.
Thadepalli
H
H
Department of Medicine, Martin Luther King, Jr. General Hospital, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Lou
M A
MA
Prabhala
R H
RH
Mandal
A K
AK
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry; D001424:Bacterial Infections / Q000517:prevention & control*; D002981:Clindamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D013997:Time Factors; D014948:Wounds, Gunshot / Q000188:drug therapy* / Q000382:microbiology
D005839:Gentamicins; D002981:Clindamycin; D008802:Mezlocillin