Dose effects on heart rate conditioning when pentobarbital is the CS and amphetamine is the US.
If sodium pentobarbital is injected into rats 30 min prior to d-amphetamine sulphate on four or five occasions, there is a learned effect of pentobarbital on heart rate. The conditioned response is a higher heart rate than found in rats with a control history of exposure to the same drugs. In Experiment 1, when the pentobarbital dose was 32 mg/kg throughout, this effect was obtained with amphetamine doses of 2, 4, 8, or 16 mg/kg. In Experiment 2, when the amphetamine dose was 12 mg/kg throughout, pentobarbital doses of 16 and 32 mg/kg yielded conditioning, while 8 mg/kg yielded equivocal results.
Revusky
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Department of Psychology, Memorial University, St. John's, Newfoundland, Canada.
Reilly
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D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010424:Pentobarbital; D003913:Dextroamphetamine