Extrageniculate vision in hemianopic humans: saccade inhibition by signals in the blind field.
The functional competence of extrageniculate visual pathways in hemianopic humans was demonstrated by showing that distractor signals in the blind half of the visual field could inhibit saccades toward targets in the intact visual field. This inhibitory effect of unseen distractors in patients occurred only when distractors were presented in the temporal half of the visual field, was specific to oculomotor responses, and did not occur in normal subjects. These results show that a peripheral visual signal activates retinotectal pathways to prime the oculomotor system and that these pathways can mediate orienting behavior in hemianopic humans.
Rafal
R
R
Department of Clinical Neurosciences, Brown University, Providence, RI 02908.
Smith
J
J
Krantz
J
J
Cohen
A
A
Brennan
C
C
D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006423:Hemianopsia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D012016:Reference Values; D012438:Saccades; D012607:Scotoma / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014785:Vision, Ocular; D014794:Visual Fields