[A case report of high plasma renin activity in chronic pulmonary disease and the effect of angiotensin-II-analogue (1-sarcosine, 8-isoleucine-angiotensin-II)].
Five patients with chronic pulmonary diseases (3 pulmonary emphysema, 1 chronic respiratory failure caused by old tuberculosis, 1 diffuse panbronchiolitis) showed a marked increase of plasma angiotensin-I and PRA level, which was accompanied by an increase of angiotensin-II level, however, whose systemic blood pressure was not elevated. The intravenous infusion of angiotensin-II-analogue (1-Sarcosine, 8-Isoleucine-Angiotensin-II) elicited an antagonistic blood pressure response resembling Bartter's syndrome.
Nakano
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Yamamoto
T
T
Fujioka
H
H
Maeda
J
J
Iwahashi
N
N
Tamura
S
S
Hada
T
T
Higashino
K
K
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology*; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D012083:Renin / Q000097:blood*
D000804:Angiotensin II; D000803:Angiotensin I; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012083:Renin