Vitamin B6 in the treatment of the premenstrual syndrome--a review.
A search of the literature yielded 12 controlled trials on vitamin B6 in the treatment of the premenstrual syndrome. These are discussed with emphasis on methodological aspects. A major drawback of the trials is the limited number of patients included. The existing evidence of positive effects of vitamin B6 is weak, and some well-designed trials with positive results would be needed to change this view.
Kleijnen
J
J
Department of Epidemiology/Health Care Research, University of Limburg, Maastricht, The Netherlands.
Ter Riet
G
G
Knipschild
P
P
D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D011293:Premenstrual Syndrome / Q000188:drug therapy*; D011736:Pyridoxine / Q000627:therapeutic use*; D012107:Research Design
D011736:Pyridoxine