Uremic serum inhibits monocyte-dependent, but not interleukin-2-dependent steps of T cell proliferation.
We examined the influence of uremic serum on antigen receptor triggered T cell proliferation in dialysis patients with impaired immune function, i.e., 12 nonresponders to hepatitis B vaccination. The dialysis patients showed a monocyte dysfunction and an increased responsiveness to interleukin 2 (IL-2) according to our previous findings. In vitro the addition of IL-2 completely reconstituted the defect. Uremic serum inhibited monocyte-dependent T cell proliferation of patients and of healthy controls. Contrary, monocyte-independent steps of T cell proliferation were not impaired by uremic serum. When IL-2 was added to cultures, the T cell proliferation in the presence of uremic serum was even enhanced. We conclude that uremic immunodeficiency may be enhanced by soluble factors present in uremic serum which inhibit monocyte-dependent steps of T cell proliferation.
Dumann
H
H
I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität, Mainz, FRG.
Meuer
S C
SC
Köhler
H
H
D000328:Adult; D000368:Aged; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology; D014511:Uremia / Q000097:blood / Q000276:immunology*
D007376:Interleukin-2; D013491:Suppressor Factors, Immunologic