Potential contribution of lysosomal proteases to cyclosporine-A-induced nephrotoxicity.
Olbricht
C J
CJ
Division of Nephrology, Hannover Medical School, F.R.G.
Gröne
H J
HJ
Gutjahr
E
E
Bossaller
C
C
D000818:Animals; D002401:Cathepsin B / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000378:metabolism; D003524:Cyclosporins / Q000008:administration & dosage / Q000633:toxicity*; D003546:Cysteine Endopeptidases; D004334:Drug Administration Schedule; D010450:Endopeptidases / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects
D003524:Cyclosporins; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534280:Ctsl protein, rat