title: [Reversal of high-dose fentanyl anesthesia by naloxone].
abstract: The EEG, respiratory and hemodynamic responses to postoperative reversal by naloxone of high-dose fentanyl anesthesia were studied in 20 patients (17 cardiac and 3 non-cardiac surgeries). In power spectrum analysis of EEG, power of delta band markedly decreased after naloxone drip infusion. Respiratory and hemodynamic responses were minimum, but increase in HR by 6.4 +/- 9.2 bpm, increase in diastolic BP by 5.3 +/- 9.6 mmHg, and decrease in CVP by 1.9 +/- 2.9 mmHg were statistically significant. Emergence of pain was also minimum and severe side effect was not observed. Reversal of high-dose fentanyl anesthesia by naloxone can reduce the incidence of postoperative respiratory depression and enables early extubation.
authors.affiliation: Department of Anesthesia and Critical Care, Hiroshima City Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Takatori
mesh_terms: D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D005283:Fentanyl / Q000037:antagonists & inhibitors*; D006801:Humans; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*
chemical_list: D009270:Naloxone; D005283:Fentanyl