Tissue spaces during development and regression of the decidual cell reaction in ovariectomized, steroid-treated mice.
Changes in the extracellular and blood spaces of the uterus were assessed from the distribution volumes of 51Cr-EDTA and 51Cr-labelled red blood cells during the development and regression of the artificially induced decidual cell reaction in ovariectomized, steroid-treated mice. The normally high values for uterine extracellular space (0.35-0.40 microliter/mg) fell to less than 0.20 microliter/mg in association with decidual growth. Uterine blood space increased from around 0.02 microliter/mg to 0.03-0.05 microliter/mg with decidual development. Induction of decidual regression by removal of s.c. progesterone implants caused a rapid decline in tissue blood volume to reach control values (0.01-0.02 microliter/mg) within 24 h and preceded any reduction in uterine weight. Uterine vascular permeability, as determined from the tissue accumulation of 125I-labelled human serum albumin, fell with a similar time course. Tissue extracellular space returned to the higher control values within 48 h of initiating decidual regression.
Milligan
S R
SR
Department of Physiology, King's College, Strand, London, UK.
Edwards
C
C
D000818:Animals; D001810:Blood Volume / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D005110:Extracellular Space / Q000502:physiology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*
D011374:Progesterone