Increased lipid peroxidation in kidney of vitamin B-6 deficient rats.
Lipid peroxidation in kidney of rats fed with vitamin B-6 deficient diet for a period of 12 weeks was studied with pair-fed controls. The basal lipid peroxide level as well as the degree of susceptibility to lipid peroxidation in presence of promotors such as NADPH, ascorbate, t-butyl hydroperoxide, Fe2+, Cu2+ and oxalate, were increased in vitamin B-6 deficient kidney. The observed increased lipid peroxidation in vitamin B-6 deficient kidney was correlated with high levels of lipids, copper, iron, calcium and oxalate, low levels of antioxidants and antioxidant enzymes and increased levels of hydroperoxides and hydroxyl radicals.
Ravichandran
V
V
Department of Medical Biochemistry, University of Madras, India.
Selvam
R
R
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007669:Kidney Calculi / Q000209:etiology; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010070:Oxalates / Q000378:metabolism; D019815:Oxalic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D026681:Vitamin B 6 Deficiency / Q000150:complications / Q000378:metabolism*
D000975:Antioxidants; D010070:Oxalates; D019815:Oxalic Acid; D002118:Calcium