Autoradiographic localization of receptor sites of 3H-spiroperidol in the CNS of rat.
Our study presents macroautoradiographic maps of the distribution of 3H-spiroperidol in the CNS of rat. The radioactively labeled butyrophenone neurolepticum enables in vivo after brain intraventriculo-cisternal perfusion an exacter autoradiographic localization of dopamine receptors in various regions of the brain. For the first time 3H-spiroperidol has been administered by intraventriculo-cisternal perfusion. Also original are the finding of receptor labelling by means of 3H-spiroperidol on astroglia and in the spinal grey matter.
Parízek
J
J
Institute of Biology, Anatomy, Histology and Embryology, Department of Anatomy, Hradec Králové.
D000818:Animals; D001345:Autoradiography; D002490:Central Nervous System / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis*
D011954:Receptors, Dopamine; C031611:spiroperidol receptor