title: Effect on human liver glycosidases and short syntheses of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine from D-glycero-D-gulo-heptono-1,4-lactone.
abstract: The synthesis of 1 alpha,2 alpha,6 alpha,7 alpha,7a beta-1,2,6,7-tetrahydroxypyrrolizidine (1) from D-glycero-D-gulo-heptono-1,4-lactone (6) by two different routes is reported. The effects of 1 on the inhibition of 15 human liver glycosidases are described.
authors.affiliation: Dyson Perrins Laboratory, Oxford University, UK.
authors.forename: W F
authors.initials: WF
authors.lastname: Collin
authors.forename: G W
authors.initials: GW
authors.lastname: Fleet
authors.forename: M
authors.initials: M
authors.lastname: Haraldsson
authors.forename: I
authors.initials: I
authors.lastname: Cenci di Bello
authors.forename: B
authors.initials: B
authors.lastname: Winchester
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011758:Pyrroles; C065904:1,2,6,7-tetrahydroxypyrrolizidine; D006026:Glycoside Hydrolases