Identification of human immunodeficiency virus hybridizing sequences in the peripheral blood of a patient with systemic lupus erythematosus.
Systemic lupus erythematosus, a multisystemic disorder, is considered a prototype of the autoimmune diseases. Although its cause remains unknown, a viral etiology has been proposed. We report that a rapid and sensitive messenger RNA in situ hybridization technique detected hybridizing sequences to the human immunodeficiency virus type in the peripheral blood cells of a woman with systemic lupus erythematosus in whom the presence of acquired immuno-deficiency syndrome was reasonably excluded.
Blick
M
M
Department of Clinical Immunology and Biological Therapy, University of Texas M. D. Anderson Cancer Center, Houston.
Bresser
J
J
Lepe-Zuniga
J L
JL
Goodacre
A
A
Luethke
D
D
Holder
W R
WR
Duvic
M
M
D000328:Adult; D015153:Blotting, Western; D004279:DNA, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005784:Gene Amplification; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics*
D004279:DNA, Viral; D012367:RNA, Viral