Successful use of rifampicin in the treatment of tuberculosis in renal transplant patients immunosuppressed with cyclosporine.
Cyclosporine and rifampicin were used simultaneously in 6 renal transplant patients with tuberculosis. The total daily dose of cyclosporine had to be increased 3-5 fold, with the frequency of administration increased from twice to thrice daily. With this regimen, satisfactory cyclosporine levels were attained and there was no adverse affect on graft function.
al-Sulaiman
M H
MH
Department of Nephrology, Riyadh Armed Forces Hospital, Saudi Arabia.
Dhar
J M
JM
al-Khader
A A
AA
D000328:Adult; D003524:Cyclosporins / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012293:Rifampin / Q000008:administration & dosage* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D003524:Cyclosporins; D012293:Rifampin