Is radical hysterectomy always necessary in early cervical cancer?
A semiquantitative histopathologic grading system was used in combination with flow cytometric measurements of tumor cell DNA content to predict the risk of lymph node metastases in early cervical cancer. A retrospective study of 126 stage IB patients showed that a group with no risk of lymph node involvement could be identified by the use of both the histopathologic score and the DNA index. The results were confirmed in a prospective investigation of 59 new patients. Simple hysterectomy may be advised in low-risk patients.
Jakobsen
A
A
Department of Oncology, Aarhus University Hospital, Denmark.
Bichel
P
P
Ahrons
S
S
Nyland
M
M
Knudsen
J
J
D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*
D004273:DNA, Neoplasm