Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen.
Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.
Hamsíková
E
E
Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia.
Závadová
H
H
Kutinová
L
L
Ludvíková
V
V
Krchnák
V
V
Némecková
S
S
Vonka
V
V
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology*
D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; C050807:presurface protein 2, hepatitis B surface antigen