title: Is radical hysterectomy always necessary in early cervical cancer?
abstract: A semiquantitative histopathologic grading system was used in combination with flow cytometric measurements of tumor cell DNA content to predict the risk of lymph node metastases in early cervical cancer. A retrospective study of 126 stage IB patients showed that a group with no risk of lymph node involvement could be identified by the use of both the histopathologic score and the DNA index. The results were confirmed in a prospective investigation of 59 new patients. Simple hysterectomy may be advised in low-risk patients.
authors.affiliation: Department of Oncology, Aarhus University Hospital, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Jakobsen
authors.forename: P
authors.initials: P
authors.lastname: Bichel
authors.forename: S
authors.initials: S
authors.lastname: Ahrons
authors.forename: M
authors.initials: M
authors.lastname: Nyland
authors.forename: J
authors.initials: J
authors.lastname: Knudsen
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D004273:DNA, Neoplasm