Prevention of acetaminophen-induced hepatotoxicity by endotoxin in mice.
A preliminary trial was conducted to determine if endotoxin would prevent acetaminophen (APAP)-induced hepatic toxicity. When mice were pretreated with endotoxin (1, 2 and 4 mg/kg, i.p.), the clinical chemistry profile and pathological alterations caused by APAP were reduced with a dose dependent manner. The efficacy of endotoxin in preventing APAP-induced hepatic necrosis should be further studied.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Tanno
K
K
Takayanagi
Y
Y
Sasaki
K
K
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009336:Necrosis / Q000473:pathology
D004731:Endotoxins; D008070:Lipopolysaccharides; D000082:Acetaminophen; D000410:Alanine Transaminase