Methyl vinyl sulphone: a new class of Michael-type genotoxin.
Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.
Warr
T J
TJ
School of Biological Sciences, University College of Swansea, Singleton Park, Great Britain.
Parry
J M
JM
Callander
R D
RD
Ashby
J
J
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005796:Genes / Q000187:drug effects*; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D013450:Sulfones / Q000633:toxicity*
D000178:Acrylamides; D013450:Sulfones; D020106:Acrylamide; C060916:methyl vinyl sulfone