Effects of insulin-like growth factor I in man.
A 6-day period of subcutaneous infusion with recombinant human insulin-like growth factor I in three healthy male volunteers resulted in an increase in the ratio of insulin to C-peptide levels and significant decreases in triglyceride levels and the ratio of total to high density lipoprotein-cholesterol in serum. Increased renal plasma flow and glomerular filtration rates were also observed.
Guler
H P
HP
Department of Medicine, University Hospital, Zürich, Switzerland.
Schmid
C
C
Zapf
J
J
Froesch
E R
ER
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D013006:Growth Hormone / Q000494:pharmacology; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood / Q000493:pharmacokinetics; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D011994:Recombinant Proteins; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone