Hormonal changes after parabolic flight: implications on the development of motion sickness.
Twenty-two different humoral parameters including stress-, gastrointestinal- and volume-regulating hormones were measured before and within 45 min after parabolic flight maneuvers of twenty healthy adult subjects. We compared hormonal data of motion sickness-affected participants with those unaffected. Changes in cortisol and vasoactive intestinal peptide plasma levels were significantly different (p less than 0.002 and p less than 0.004) between the two groups with increasing plasma levels of both hormones during motion sickness but decreasing levels within the control group. Growth hormone and prolactin plasma levels increased by 400% and 115% within the motion sickness-affected group and to a smaller degree (120% and 40% increases, respectively) within the control group, while ACTH levels were almost unchanged within both groups. Pancreatic polypeptide and gastrin plasma levels as well as plasma levels of insulin and C-peptide were significantly decreased within both groups after the parabolic flight. Plasma renin, aldosterone, atrial natriuretic peptide and cyclic GMP levels were unchanged within the control group. Within the motion sickness-affected group, plasma renin and aldosterone levels were decreased and atrial natriuretic peptide levels increased after the flight. Humoral parameters of the thyroid gland were neither changed within the groups nor different between the groups. The present data confirm previous results that increases in plasma levels of certain stress hormones participate in motion sickness. Furthermore, increases in vasoactive intestinal peptide levels participate in motion sickness. These increases could explain some of the gastrointestinal symptoms in motion sickness and might serve as markers for a discrimination between regular stress and motion sickness.
Drummer
C
C
Medizinische Klinik Innenstadt, Universität München, FRG.
Stromeyer
H
H
Riepl
R L
RL
König
A
A
Strollo
F
F
Lang
R E
RE
Maass
H
H
Röcker
L
L
Gerzer
R
R
D005260:Female; D006112:Gravitation; D006728:Hormones / Q000097:blood* / Q000502:physiology; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D009325:Nausea / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D013026:Space Flight; D013312:Stress, Physiological / Q000097:blood*
D006728:Hormones