title: Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.
abstract: Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). Nine patients were evaluable for either a tumour or clinical response. Six of these demonstrated an event-free response that was maintained for periods of between 7 and 26 months.
authors.affiliation: Department of Neurosurgery, Frenchay Hospital, Bristol, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Moseley
authors.forename: A G
authors.initials: AG
authors.lastname: Davies
authors.forename: R B
authors.initials: RB
authors.lastname: Richardson
authors.forename: M
authors.initials: M
authors.lastname: Zalutsky
authors.forename: S
authors.initials: S
authors.lastname: Carrell
authors.forename: J
authors.initials: J
authors.lastname: Fabre
authors.forename: N
authors.initials: N
authors.lastname: Slack
authors.forename: J
authors.initials: J
authors.lastname: Bullimore
authors.forename: B
authors.initials: B
authors.lastname: Pizer
authors.forename: V
authors.initials: V
authors.lastname: Papanastassiou
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000528:radiation effects; D002423:Cause of Death; D006801:Humans; D007278:Injections, Spinal; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008577:Meningeal Neoplasms / Q000401:mortality / Q000628:therapy*; D008581:Meningitis / Q000401:mortality / Q000628:therapy*; D010865:Pilot Projects; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes