title: Hierarchical models for multicentre binary response studies.
abstract: A three-stage hierarchical model is proposed for two treatment, binary response studies conducted in a number of centres. The approach adopted is Bayesian. Marginal densities for second stage parameters are shown to provide useful summaries both of comparative efficacy and of the heterogeneity of treatment effects across centres. Sensitivity studies of model assumptions are illustrated.
authors.affiliation: British Heart Foundation Cardiovascular Statistics Group, University of Nottingham, University Park, U.K.
authors.forename: A M
authors.initials: AM
authors.lastname: Skene
authors.forename: J C
authors.initials: JC
authors.lastname: Wakefield
mesh_terms: D001499:Bayes Theorem; D002986:Clinical Trials as Topic; D006801:Humans; D016015:Logistic Models; D015233:Models, Statistical; D009010:Monte Carlo Method; D015337:Multicenter Studies as Topic / Q000379:methods; D016017:Odds Ratio; D010919:Placebos; D011336:Probability; D012680:Sensitivity and Specificity; D013812:Therapeutics / Q000706:statistics & numerical data
chemical_list: D010919:Placebos