title: Learning abilities of rats in multiple T-mazes of two degrees of complexity under the influence of d-amphetamine.
abstract: The effect of d-amphetamine on the learning capacity of male Wistar rats was investigated in multiple T-mazes in two experiments of increasing or decreasing degree of difficulty. Running speed, distance covered and the number of errors were scored to indicate proficiency and success of learning. These parameters, as well as the distribution of errors (goal-directed orientation), correction of errors (situational orientation) and latency at the decision points (discrimination time) were considered to represent cognitive components. The results demonstrated an experiment effect in that the rats showed more difficulty in learning, as exhibited by a slower running speed and more errors, in the maze with successively increasing demands than in the one with decreasing demands. Oral self-administered d-amphetamine in a dosage of 3-4 mg/kg/day or 7-8 mg/kg/day significantly increased the running speed in a dose-dependent manner. By contrast, success of learning and goal-directed orientation decreased. Situational orientation was, however, dose-dependently improved, at least in the experiment with the increasing demand.
authors.affiliation: Institute of Neuropsychopharmacology, Free University of Berlin, FRG.
authors.forename: U A
authors.initials: UA
authors.lastname: Jänicke
authors.forename: B
authors.initials: B
authors.lastname: Jänicke
authors.forename: G
authors.initials: G
authors.lastname: Schulze
authors.forename: H
authors.initials: H
authors.lastname: Coper
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003913:Dextroamphetamine