Nocturnal asthma, its pathogenesis and treatment.
Many chronobiologic and cyclic environmental factors are implicated in the pathophysiology of nocturnal asthma. A better understanding of these interrelating processes is essential for an optimization of medications for asthma. A reasonable therapeutic approach for the management of nocturnal asthma is the use of inhaled beta-agonists routinely, on a daily basis, and if symptoms persist, the use of an appropriate SR theophylline scheduled once-daily in the evening. Inhaled cromolyn sodium and corticosteroid therapy, properly timed to rhythms, may be warranted to control inflammation and stabilize the airways.
D'Alonzo
G E
GE
University of Texas Health Science Center, School of Medicine, Department of Internal Medicine, Houston.
Smolensky
M H
MH
D000403:Airway Resistance / Q000502:physiology; D001249:Asthma / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002940:Circadian Rhythm / Q000502:physiology*; D004334:Drug Administration Schedule; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006728:Hormones / Q000097:blood; D006801:Humans; D009079:Mucociliary Clearance / Q000502:physiology; D011187:Posture; D012890:Sleep / Q000502:physiology
D001993:Bronchodilator Agents; D006728:Hormones