[Astrocyte death in organotypic cultures of fetal spinal cord from rats with unilateral micromelia].
Growth and differentiation of neurons and glia in spinal cord explants of 16 days old rat fetuses with teratogen-induced left-sided micromelia were studied. Progressive destruction of astrocytes that differentiate in interstitial zone of cultures was observed in 37% of explants of the left side, while the development was normal in cultures of the right side. Possible mechanisms leading to destruction of astrocytes in cultures of spinal cord regions that innervate anomalous limbs are discussed.
Bobryshev
Iu V
IuV
Balabanov
Iu V
IuV
Chebotar'
N A
NA
Konopistseva
L A
LA
D015082:2,2'-Dipyridyl / Q000633:toxicity; D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000648:ultrastructure; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005121:Extremities / Q000294:innervation; D005260:Female; D005333:Fetus; D017880:Limb Deformities, Congenital; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009024:Morphogenesis / Q000187:drug effects; D009924:Organ Culture Techniques; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000648:ultrastructure
D015082:2,2'-Dipyridyl
Gibel' astrotsitov v organotipicheskikh kul'turakh spinnogo mozga plodov krys s odnostoronneĭ mikromelieĭ.