title: [Malignant histiocytosis in children].
abstract: The analysis of peculiarities of clinical course and morphology of malignant (acute) histiocytosis in 50 pediatric patients made a case for identification of the disease as separate pathology of histiocytic sarcoma type. Clinical course features include: lymphadenopathy, involvement of bones and--less frequently--lungs, skin and subcutaneous fat, marked fever and weight loss. Cytologic and histologic examination show polymorphic tumor cells of varying degree of differentiation, with blasts predominating. Well-developed Golgi complex, presence of lysosomes, phagosomes and erythrophagocytosis are among the characteristic ultrastructural features of the disease.
authors.forename: L A
authors.initials: LA
authors.lastname: Makhonova
authors.forename: I S
authors.initials: IS
authors.lastname: Peterson
authors.forename: V I
authors.initials: VI
authors.lastname: Zemskova
authors.forename: A I
authors.initials: AI
authors.lastname: Pavlovskaia
authors.forename: P V
authors.initials: PV
authors.lastname: Koposov
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D054747:Histiocytic Sarcoma / Q000175:diagnosis* / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D011859:Radiography; D012867:Skin / Q000473:pathology
vernacular_title: Zlokachestvennyĭ gistiotsitoz u deteĭ.