Comparison of flurbiprofen and alprazolam in the management of chronic pain syndrome.
A three-process model of chronic pain comprising tissue damage, anxiety, and depression is hypothesized. Within this model, the effectiveness of flurbiprofen (for analgesia) plus either alprazolam (for anxiety and depression) or placebo was evaluated in a randomized, double-blind trial with a single crossover. Flurbiprofen was found to have a significant analgesic effect but this was not enhanced by combining it with alprazolam.
Wilson
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Addiction Services, Royal Ottawa Hospital, Ontario, Canada.
D000328:Adult; D000368:Aged; D000525:Alprazolam / Q000008:administration & dosage*; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement
D005480:Flurbiprofen; D000525:Alprazolam