Choroid plexus cysts and chromosomal defects.
During a 4-year period, 83 pregnant women with fetal choroid plexus cysts were investigated in our unit. Abnormal karyotypes were found in 20 fetuses, including trisomy 18 (n = 16), trisomy 13 (n = 1), triploidy (n = 1) and translocation Down's syndrome (n = 2). All fetuses with chromosomal defects had structural malformations in addition to the choroid plexus cysts.
Thorpe-Beeston
J G
JG
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital of Medicine and Dentistry, Denmark Hill, London.
Gosden
C M
CM
Nicolaides
K H
KH
D000015:Abnormalities, Multiple / Q000235:genetics*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D002831:Choroid Plexus; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D003560:Cysts / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D014314:Trisomy; D014463:Ultrasonography