[Adverse reactions of antituberculous agents, especially about its onset and duration].
We examined the adverse reactions of the antituberculous agents in 225 hospitalized patients (150: male, 75: female, average age: 45.4 years old) and the results were summarized as follows: 1) The side effects were seen in 53 patients (23.6%), and the abnormal laboratory findings were observed in 94 patients (41.8%). 2) The incidence of adverse reactions in patients treated with three drugs (INH, RFP, EB) and four drugs (plus SM) were 45.9% and 82.4%, respectively. 3) Adverse reaction appeared within one month after starting treatment in 67.9% of eligible patients, and it disappeared within one month from its onset in 76.8% of patients. There results suggested the importance of careful clinical observation especially soon after starting antituberculous therapy.
Yamada
H
H
2nd Department of Internal Medicine, Nagasaki University, School of Medicine, Japan.
Yasuoka
A
A
Sasayama
K
K
Doutsu
Y
Y
Hayashi
T
T
Kohno
S
S
Yamaguchi
K
K
Hirota
M
M
Hara
K
K
D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004064:Digestive System / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology
D000995:Antitubercular Agents