[Hourly serum cortisol assay over 24hr by immunoenzymology in depression].
Enzymoimmunoassays have been developed as alternatives to radioimmunoassays because they obviate the need for labelled compounds yet offering comparable specificity. The authors used an enzymoimmunoassay to investigate hourly serum cortisol levels over 24 hours in 6 patients (aged over 40 years) with endogenous depression (4 unipolar depressions, under antidepressor treatment and 2 bipolar depressions, without medication) and in 2 controls, aged 20 and 47 years. In agreement with literature data, a clear circadian rhythm was observed in controls and in the depressed patients, and hypercorticism was noted in one depressed patient. A trend towards phase advance in depression was seen in both the treated and untreated patients.
Candito
M
M
Laboratoire de Biochimie, Hôpital Pasteur, Nice, France.
Souetre
E
E
Pringuey
D
D
Krebs
B
B
Chambon
P
P
Darcourt
G
G
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood*; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D006854:Hydrocortisone
Dosage du cortisol sérique horaire pendant 24 h par enzymoimmunologie dans la dépression.