title: Renal and hemodynamic effects of endothelin in anesthetized dogs.
abstract: The effects of endothelin on systemic hemodynamics and renal functions were investigated in anesthetized dogs. Infusion of endothelin at a dose of 1 ng/kg/min decreased renal blood flow and increased renal vascular resistance and filtration fraction. Endothelin at doses higher than 10 ng/kg/min significantly decreased cardiac output, glomerular filtration rate, renal plasma flow, urine volume, and urinary sodium excretion. Mean arterial pressure showed a transient decrease at doses higher than 50 ng/kg/min. These results showed that endothelin in systemic administration has effects on renal functions as well as on systemic hemodynamics.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Naruse
authors.forename: T
authors.initials: T
authors.lastname: Sanaka
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: Z P
authors.initials: ZP
authors.lastname: Zeng
authors.forename: K
authors.initials: K
authors.lastname: Nitta
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: K
authors.initials: K
authors.lastname: Shizume
authors.forename: N
authors.initials: N
authors.lastname: Sugino
mesh_terms: D000758:Anesthesia; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004334:Drug Administration Schedule; D016232:Endothelins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D016232:Endothelins