[The effect of translation inhibitor cycloheximide on expression of mammalian genes].
The data concerning the cycloheximide influence on individual mRNA content, transcription rate and chromatin structure in mammalian cells are reviewed. The putative mechanism of cycloheximide effect is explained as being due to the existence of short-living regulatory proteins. It is concluded that cycloheximide is a helpful tool in the study of regulation of gene expression in mammalian cells.
Chesnokov
V N
VN
Mertvetsov
N P
NP
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D008322:Mammals / Q000235:genetics*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*
D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide
Vliianie ingibitora transliatsii tsiklogeksimida na ékspressiiu genov mlekopitaiushchikh.