Different levels of cardiovascular risk factors in type-2 diabetic patients with lower limb proximal and distal vessel macroangiopathy.
The levels of some cardiovascular risk factors (lipids, apolipoproteins and fibrinogen) were measured in groups of Type-2 diabetic patients with lower limb proximal (ileofemoral) and distal (trifurcational) artery macroangiopathy, diagnosed by Doppler ultrasound, and in a group of diabetics without macroangiopathy. The highest mean levels of total and LDL-cholesterol, apolipoprotein B and triacylglycerols were observed in patients with proximal vessel involvement. Significant correlations were found between the thigh/arm index and total cholesterol, LDL-cholesterol, apolipoprotein B and stroke prevalence. On the other hand, a significant correlation was found between ankle/thigh index and fibrinogen. The results of the study suggest that different pathogenetic mechanisms may play a role in the development of ileofemoral and trifurcational vessel disease.
Tkác
I
I
IVth Clinic of Medicine, School of Medicine, Safárik University, Kosice, Czechoslovakia.
Moscovic
F
F
Molcányová
A
A
Lazúr
J
J
Takác
M
M
D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007866:Leg / Q000098:blood supply*; D012307:Risk Factors; D014463:Ultrasonography
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D005340:Fibrinogen; D002784:Cholesterol