title: Autoregulation of the glomerular filtration rate and the single-nephron glomerular filtration rate despite inhibition of tubuloglomerular feedback in rats chronically volume-expanded by deoxycorticosterone acetate.
abstract: Tubuloglomerular feedback (TGF) function and autoregulation (renal blood flow RBF; glomerular filtration rate, GFR; single-nephron glomerular filtration rate, SNGFR) were examined in rats chronically treated with deoxycorticosterone acetate (DOCA) and given isotonic saline to drink. DOCA treatment depressed arterial plasma renin activity, expanded plasma volume by 25% and increased arterial blood pressure. Autoregulation of RBF and GFR was maintained in the DOCA animals above 90 mm Hg and 110 mm Hg respectively, whereby both GFR and RBF were lower than in controls. Micropuncture experiments demonstrated the absence of TGF in the DOCA animals. There was no difference between SNGFR values measured in the distal and proximal tubules, nor was there a significant response of SNGFR when loops of Henle were perfused with Ringer's solution at 20 nl/min. Loop perfusion in control rats with tubular fluid collected in DOCA rats elicited a normal TGF response, showing that TGF inhibition in the DOCA animals is due to changes in the function of the juxtaglomerular apparatus. In contrast to control rats, proximal SNGFR was perfectly autoregulated. These results suggest that TGF is not primarily responsible for autoregulation and that the vasodilatation normally resulting from acute TGF interruption is therefore compensated by some other mechanism such that RBF and GFR are lower than in controls.
authors.affiliation: Physiologisches Institut, Universität München, Federal Republic of Germany.
authors.forename: D A
authors.initials: DA
authors.lastname: Häberle
authors.forename: B
authors.initials: B
authors.lastname: Königbauer
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: T
authors.initials: T
authors.lastname: Kawata
authors.forename: C
authors.initials: C
authors.lastname: Mast
authors.forename: C
authors.initials: C
authors.lastname: Metz
authors.forename: H
authors.initials: H
authors.lastname: Dahlheim
mesh_terms: D000818:Animals; D001158:Arteries; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology; D005246:Feedback; D005919:Glomerular Filtration Rate; D006706:Homeostasis; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*; D008297:Male; D009399:Nephrons / Q000502:physiology*; D010953:Plasma Volume / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000502:physiology; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D003900:Desoxycorticosterone; D012965:Sodium Chloride; D012083:Renin