title: [Changes in lymphocyte subpopulations induced by the administration of thymopentin].
abstract: Modifications of the levels of T-helper (T4) and T-suppressor (T8) lymphocytes were assessed, together with their ratio, in 17 subjects who had received thymopentine as an adjuvant to Hevac-B vaccination. Two months after treatment with the immunomodulating drug, T4 lymphocytes were considerably increased whereas absolute levels of T8 lymphocytes were decreased in the majority of patients: this led to a net increase in the T4/T8 ratio. This finding leads to the conclusion that all subjects produced anti-HBs antibodies as a means of protection.
authors.affiliation: Divisione di Malattie Infettive, Ospedale Civile, Alessandria.
authors.forename: P L
authors.initials: PL
authors.lastname: Garavelli
authors.forename: M
authors.initials: M
authors.lastname: Ciriello
mesh_terms: D000328:Adult; D005260:Female; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D016305:Thymopentin / Q000494:pharmacology*; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
chemical_list: D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines; D016305:Thymopentin
vernacular_title: Modificazioni delle sottopopolazioni linfocitarie indotte dalla somministrazione di timopentina.