Pulmonary infiltrates and fever induced by isoniazid.
An 88 year old woman with bacteriologically confirmed pulmonary tuberculosis was first treated with isoniazid, rifampicin and pyrazinamide. Two weeks later she developed pulmonary infiltrates with fever. A drug-induced reaction was suspected but the reaction recurred three times until isoniazid was identified as the cause. The reaction became worse each time, finally being nearly fatal.
Salomaa
E R
ER
Department of Diseases of the Chest, University Central Hospital of Turku, Preitilä, Finland.
Ruokonen
E L
EL
Tevola
K
K
Tala
E
E
D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000175:diagnosis; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D007538:Isoniazid