title: Quantitative electroencephalographic correlates of cognitive decline in normal elderly subjects.
abstract: We obtained a topographic computer analysis of the electroencephalogram in 53 normal elderly subjects. Normal aging was not associated with an increase in slow (delta) activity. However, cognitive performance correlated positively with fast (beta) activity particularly in frontal leads, even after controlling for age, education, occupation, and medication. Five subjects who showed early signs of cognitive decline, had all a marked reduction in beta activity suggesting that this may be an early indication of intellectual loss.
authors.affiliation: London Psychiatric Hospital, Ontario, Canada.
authors.forename: P C
authors.initials: PC
authors.lastname: Williamson
authors.forename: H
authors.initials: H
authors.lastname: Merskey
authors.forename: S
authors.initials: S
authors.lastname: Morrison
authors.forename: K
authors.initials: K
authors.lastname: Rabheru
authors.forename: H
authors.initials: H
authors.lastname: Fox
authors.forename: K
authors.initials: K
authors.lastname: Wands
authors.forename: C
authors.initials: C
authors.lastname: Wong
authors.forename: V
authors.initials: V
authors.lastname: Hachinski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D001611:Beta Rhythm; D003071:Cognition; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D011581:Psychological Tests; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted