title: Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS).
abstract: The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (beta blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) doxazosin (alpha 1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55455.
authors.forename: S R
authors.initials: SR
authors.lastname: Mascioli
authors.forename: R H
authors.initials: RH
authors.lastname: Grimm
authors.forename: J D
authors.initials: JD
authors.lastname: Neaton
authors.forename: J
authors.initials: J
authors.lastname: Stamler
authors.forename: R J
authors.initials: RJ
authors.lastname: Prineas
authors.forename: J A
authors.initials: JA
authors.lastname: Cutler
authors.forename: P J
authors.initials: PJ
authors.lastname: Elmer
authors.forename: R
authors.initials: R
authors.lastname: McDonald
authors.forename: H
authors.initials: H
authors.lastname: Schnaper
authors.forename: J
authors.initials: J
authors.lastname: Schoenberger
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use; D001794:Blood Pressure; D004039:Diet, Sodium-Restricted; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
chemical_list: D000959:Antihypertensive Agents