title: [Myocardial adrenergic derangement due to myocardial ischemia: decreased myocardial uptake of I-123 metaiodobenzylguanidine after PTCA in a patient with effort angina].
abstract: Regional denervation of adrenergic nerves has been clinically demonstrated in patients with myocardial infarction using I-123 metaiodobenzylguanidine (MIBG) scintigraphy. However, it is not clarified whether adrenergic denervation can be induced by prolonged myocardial ischemia as well as by myocardial infarction. This case with effort angina had 99% stenosis of right coronary artery and showed perfusion defects at inferior myocardial regions in the exercise thallium-201 study. However, inferior wall motion estimated by echocardiography and left ventriculography was normal indicating the absence of myocardial infarction. After percutaneous transluminal coronary angioplasty for the stenosis, I-123 metaiodobenzylguanidine (MIBG) and thallium-201 (Tl-201) myocardial scintigraphies were done to estimate the therapeutic effect of PTCA. Although the Tl-201 study during exercise showed normal findings indicating the success of PTCA, marked defects was detected at inferior myocardial regions in the I-123 MIBG studies just after and 4 hours after an intravenous injection of I-123 MIBG. These results suggest that adrenergic derangement may be induced by prolonged myocardial ischemia and may persist for periods even though myocardial perfusion is normalized.
authors.affiliation: First Department of Medicine, Osaka University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Morozumi
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: A
authors.initials: A
authors.lastname: Tani
authors.forename: J
authors.initials: J
authors.lastname: Tanouchi
authors.forename: M
authors.initials: M
authors.lastname: Hori
authors.forename: A
authors.initials: A
authors.lastname: Kitabatake
authors.forename: T
authors.initials: T
authors.lastname: Kamada
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Kozuka
mesh_terms: D019797:3-Iodobenzylguanidine; D000787:Angina Pectoris / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine