title: Neoadjuvant Cis-DDP in esophageal cancers: an experience at a regional cancer centre, India.
abstract: We are analysing the results of 80 patients who underwent surgery during 1983-84 for esophageal cancer. Forty patients who received pre-operative single agent Cis-DDP were grouped under "A" and 40 patients who went for surgery directly were grouped under "B". Twenty-two patients (55%) of Group A showed tumor necrosis. Both groups underwent resection and hand-sewn anastamosis of the esophagus. There were 10 post-operative deaths among 80 resected cases, 9 of them being from anastomatic leak. Cis-DDP has induced negligible side effects. A comparatively high survival rate during early years in patients who responded to Cis-DDP suggests that neoadjuvant chemotherapy might be of value.
authors.affiliation: Department of Surgery, Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Murthy
authors.forename: P S
authors.initials: PS
authors.lastname: Prabhakaran
authors.forename: M
authors.initials: M
authors.lastname: Chandrashekar
authors.forename: R
authors.initials: R
authors.lastname: Deshpande
authors.forename: D C
authors.initials: DC
authors.lastname: Doval
authors.forename: K S
authors.initials: KS
authors.lastname: Gopinath
mesh_terms: D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D002945:Cisplatin