title: Uneventful delivery following series of successive treatments for virilized Cushing syndrome due to adrenocortical carcinoma.
abstract: A twenty-one-year-old virilized woman with Cushing syndrome due to a huge adrenocortical carcinoma was successively treated with trilostane (3 beta-hydroxysteroid dehydrogenase inhibitor), subsequent adrenalectomy, and postoperative cis-platinum. Clinical or biochemical abnormalities peculiar to Cushing syndrome gradually subsided, and three and one-half years after the adrenal surgery, the patient delivered a normal female infant. This study points out some of the clinical and biochemical responses of each treatment.
authors.affiliation: Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakada
authors.forename: H
authors.initials: H
authors.lastname: Koike
authors.forename: T
authors.initials: T
authors.lastname: Katayama
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000628:therapy*; D000315:Adrenalectomy; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000209:etiology / Q000628:therapy*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: D000970:Antineoplastic Agents; D013196:Dihydrotestosterone; C009954:trilostane; D002945:Cisplatin