Soluble class 1 antigens (sHLA) in CSF and serum of patients with HIV infection.
sHLA are secreted by B and T lymphocytes upon activation. These antigens are present in serum and cerebrospinal fluid (CSF). The establishment of a sHLA index, IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin) helped us to define that values above 9.7 reflect an intrathecal synthesis of these proteins. IH was significantly increased in a group of patients with intrathecal production of IgG against HIV-1 (HIV) and directly correlated with the synthesis of such antibodies. Therefore, IH seems to be an index of lymphocyte activation in CNS.
Alvarez-Cermeño
J C
JC
Department of Neurology, Hospital Ramon y Cajal, Madrid, Spain.
Casado
C
C
Villar
L M
LM
Ferreira
A
A
Varela
J M
JM
Dominguez
M
M
Bootello
A
A
Najera
R
R
Gonzalez-Porque
P
P
D015658:HIV Infections / Q000097:blood* / Q000134:cerebrospinal fluid / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D012995:Solubility
D015395:Histocompatibility Antigens Class I