title: [Experience with long-term outpatient use of cordarone in the prevention of paroxysms of atrial fibrillation (flutter)].
abstract: In a group of 250 patients suffering from frequent paroxysms of atrial fibrillations (flutters), the application of cordarone for 1 to 5 years prevented the occurrence of arrhythmic paroxysms in 23.6%, contributed to a reduction of their numbers up to 1 a year in 35.6%, up to 2-3 a year in 20.4%. Good and satisfactory results were obtained nearly in 80% of the patients. Cordarone failed to act in 10.4%. In 12.8%, the "escape" phenomenon was observed, i.e. loss of the agents' action following its long-acting effect when the patients were on a maintenance dosage. The results of the preventive usage of cordarone were not clearly related to the degree of atrial dilatation and the pattern of cardiac disease.
authors.forename: M S
authors.initials: MS
authors.lastname: Kushakovskiĭ
authors.forename: G A
authors.initials: GA
authors.lastname: Rebrova
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000517:prevention & control*; D001282:Atrial Flutter / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000638:Amiodarone
vernacular_title: Opyt dlitel'nogo ambulatornogo primeneniia kordarona dlia profilaktiki paroksizmov fibrilliatsii (trepetaniia) predserdiĭ.