Meropenem pharmacokinetics and penetration into an inflammatory exudate.
The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem in plasma was 1.1 h, with the concentration in plasma declining from a mean of 23.6 micrograms/ml at 1 h to 0.7 micrograms/ml at 6 h. The inflammatory fluid penetration was rapid (time to maximum concentration of drug in serum, 0.75 h), and the penetration was 111%. The recovery of meropenem in urine at 24 h was 65.4% of the administered dose.
Wise
R
R
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, England.
Logan
M
M
Cooper
M
M
Ashby
J P
JP
Andrews
J M
JM
D000328:Adult; D005122:Exudates and Transudates / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D000077731:Meropenem; D013845:Thienamycins / Q000009:adverse effects / Q000493:pharmacokinetics*
D013845:Thienamycins; D000077731:Meropenem