title: Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm.
abstract: The magnitudes of pulmonary responses we previously observed (1) following 6.6-h exposures to 0.12 ppm ozone (O3) suggested that responses would also occur with similar exposures at lower O3 concentrations. The objective of this study was to determine the extent of pulmonary function decrements, respiratory discomfort, and increased airway reactivity to methacholine induced by exposure to O3 below 0.12 ppm. Separate 6.6-h chamber exposures to 0.00, 0.08, 0.10, and 0.12 ppm O3 included six 50-min periods of moderate exercise (VE approximately equal to 39 L/min, HR approximately equal to 115 bpm, and VO2 approximately equal to 1.5 L/min). Each exercise period was followed by 10 min of rest. A 35-min lunch break was included midway through the exposure. Although not intended as an exact simulation, the overall duration, intensity, and metabolic requirements of the exercise performed were representative of a day of moderate to heavy work or play. Preexposure FEV1 averaged 4.39 L, and essentially no change (+0.03 L) occurred with exposure to 0.00 ppm O3. Significant decreases (p less than 0.01) of -0.31, -0.30, and -0.54 L were observed with exposures to 0.08, 0.10, and 0.12 ppm, respectively. The provocative dose of methacholine required to increase airway resistance by 100% (PD100) was 58 cumulative inhalation units (CIU) following exposure to 0.00 ppm and was significantly reduced (p less than 0.01) to 37 CIU at 0.08, 31 CIU at 0.10, and 26 CIU at 0.12 ppm O3; reductions in PD100 are considered indicative of increases in nonspecific airway responsiveness.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: United States Environmental Protection Agency Health Effects Research Laboratory, Research Triangle Park, North Carolina 27711.
authors.forename: D H
authors.initials: DH
authors.lastname: Horstman
authors.forename: L J
authors.initials: LJ
authors.lastname: Folinsbee
authors.forename: P J
authors.initials: PJ
authors.lastname: Ives
authors.forename: S
authors.initials: S
authors.lastname: Abdul-Salaam
authors.forename: W F
authors.initials: WF
authors.lastname: McDonnell
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D001985:Bronchial Provocation Tests; D015444:Exercise; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008448:Maximal Expiratory Flow Rate; D016210:Methacholine Chloride; D010126:Ozone / Q000008:administration & dosage / Q000633:toxicity*; D015656:Respiratory Mechanics; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D016210:Methacholine Chloride; D010126:Ozone