title: Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients.
abstract: Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients were identified by either single or two color analysis with fluorescence activated cell sorter-IV (FACS-IV) using monoclonal antibodies. The absolute and percentages of CD3+ (mature T) cells and CD4+ (helper/inducer T) cells in peripheral blood from the advanced cancer patients were significantly lower than those from normal healthy controls. In peripheral blood, a significant decrease of CD4+ cells was due to the decrease of CD4+ CD45RA+ (suppressor inducer T) cells, while CD8+ CD11b+ (suppressor T) cells tended to increase with progress of the disease. CD4+ CD45RA+ cells located more predominantly in peripheral blood and spleen than in the splenic vein, while CD8+ CD11b+ cells were more predominant in the splenic vein.
authors.affiliation: Department of Surgery, Hiroshima University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kuroi
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Takayama
authors.forename: N
authors.initials: N
authors.lastname: Baba
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Toge
mesh_terms: D000911:Antibodies, Monoclonal; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal