Yeuhchukene--an indole derivative interacting with guinea pig reproduction.
Natural yuehchukene in doses of 10 mg/kg/day induced a 40% reduction of pregnancies in the guinea pig as compared with controls (p less than 0.05). Yuehchukene also caused a reduction in litter size which, however, was not significant indicating limited toxicity of the drug. An inhibition of ovum fertilization and/or implantation is suggested as the mechanism of action.
Hammarström
M
M
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
Venemalm
L
L
Bergman
J
J
Eneroth
P
P
D000818:Animals; D003270:Contraceptive Agents / Q000494:pharmacology; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology*; D010946:Plants, Medicinal; D012098:Reproduction / Q000187:drug effects*; D013997:Time Factors
D003270:Contraceptive Agents; D007213:Indomethacin