title: Auto-PEEP in the multisystem injured patient: an elusive complication.
abstract: Auto-PEEP (A-PEEP), unrecognized alveolar positive and expiratory pressure during mechanical ventilation, is an acknowledged hazard in patients with chronic obstructive lung disease. We evaluated 50 consecutive trauma patients for the presence of A-PEEP and its effect on hemodynamic stability. Injury Severity Scores (ISS) were 8 to 41 (21 +/- 1); Revised Trauma Scores (RTS) ranged from 2.0 to 7.8 (6.2 +/- 0.2). Mode of ventilation was assist control, inspiratory flow rates were 40 to 120 L/M (78 +/- 2). A-PEEP, determined in the non-assisting patient by occluding the expiratory port at end exhalation, was present in 28 patients (56%) and ranged from 1 to 12 cm H2O (5.3 +/- 0.4 cm H2O). Data segregated by A-PEEP versus no A-PEEP were as follows (Mean +/- SEM): [table: see text] *P less than 0.05, VE = minute ventilation, Paw = mean airway pressure. Upon reversal of A-PEEP in the eight patients with levels greater than 5 cm H2O, mean blood pressure rose from 90 +/- 17 to 102 +/- 22 mm Hg and central venous pressure fell from 13 +/- 5 to 7 +/- 5 mm Hg. A-PEEP was successfully treated in these eight patients by increasing peak flows, minimizing VE requirements and selective use of bronchodilators. In sum, the hypermetabolic ventilated trauma patient should be monitored routinely for this common phenomenon which may have profound cardiopulmonary effects in the setting of acute resuscitation.
authors.affiliation: Department of Surgery, Denver General Hospital, CO 80204-4507.
authors.forename: F A
authors.initials: FA
authors.lastname: Moore
authors.forename: J B
authors.initials: JB
authors.lastname: Haenel
authors.forename: E E
authors.initials: EE
authors.lastname: Moore
authors.forename: C M
authors.initials: CM
authors.lastname: Abernathy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000403:Airway Resistance; D002496:Central Venous Pressure; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000628:therapy*; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure; D012120:Respiration Disorders / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012307:Risk Factors