Antioxidant activity of and interleukin production affected by honey bee venom.
Honey bee venom is found to inhibit significantly nonenzymatic lipid peroxidation. It also possesses a considerable hydroxyl radical scavenging activity, evaluated by its competition with dimethyl sulfoxide for HO.. These results, in relation to the in vitro suppression mainly of interleukin-1 production offered by honey bee venom, may further support that antioxidant activity is involved in the anti-inflammatory activity of honey bee venom.
Rekka
E
E
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
Kourounakis
L
L
Kourounakis
P
P
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000378:metabolism / Q000494:pharmacology; D005557:Formaldehyde / Q000378:metabolism; D016166:Free Radical Scavengers; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology
D000975:Antioxidants; D001514:Bee Venoms; D016166:Free Radical Scavengers; D007375:Interleukin-1; D007376:Interleukin-2; D005557:Formaldehyde; D004121:Dimethyl Sulfoxide