The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity.
Markwell
M A
MA
Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892.
Berger
S P
SP
Paul
S M
SM
D000818:Animals; D015317:Biogenic Polyamines / Q000096:biosynthesis*; D002478:Cells, Cultured; D000518:Eflornithine / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors* / Q000633:toxicity; D009422:Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D009474:Neurons / Q000187:drug effects; D010622:Phencyclidine / Q000633:toxicity; D011247:Pregnancy; D051381:Rats
D015317:Biogenic Polyamines; D016202:N-Methylaspartate; D010622:Phencyclidine; D000518:Eflornithine