title: Major effects on teratogen-induced facial clefting in mice determined by a single genetic region.
abstract: A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% of the genome, was transferred from one strain to the other by the construction of congenic strains. 6-Aminonicotinamide-induced cleft palate and phenytoin-induced cleft lip with or without cleft palate are also influenced by this genetic region but not as strongly. In both cases the susceptible strain became quite resistant to the teratogen-induced clefting when the N-acetyl transferase region of chromosome 8 was transferred. However, this chromosomal region does not make the resistant strain susceptible to these two teratogens.
authors.affiliation: Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
authors.forename: J
authors.initials: J
authors.lastname: Karolyi
authors.forename: R P
authors.initials: RP
authors.lastname: Erickson
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Killewald
mesh_terms: D015120:6-Aminonicotinamide / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000235:genetics*; D000818:Animals; D002875:Chromosomes; D002971:Cleft Lip / Q000139:chemically induced / Q000235:genetics*; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics*; D005796:Genes; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D010672:Phenytoin / Q000633:toxicity; D013723:Teratogens
chemical_list: D013723:Teratogens; D015120:6-Aminonicotinamide; D010672:Phenytoin