title: Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep.
abstract: We have examined the effects on the cardiovascular system and on regional blood flow of propofol and thiopentone when administered with IPPV (FIO2 0.4). A longitudinal study design was used in which 16 studies were performed in eight sheep for 30 min before, during the last 30 min of 70 min anaesthesia, and for 6 h after anaesthesia. During anaesthesia with propofol and thiopentone, mean total body oxygen consumption decreased, respectively, by 47% (P less than 0.001) and 24% (P less than 0.01) of pre-anaesthesia baseline values, mean heart rate increased by approximately 50% (P less than 0.05) with both agents, mean arterial pressures increased by approximately 50% (P less than 0.05) with both agents and the mean cardiac output was unaltered with propofol anaesthesia but was decreased by 20% (P less than 0.05) with thiopentone anaesthesia. The changes in arterial pressure and heart rate were unexpected and may have been a result of a species-specific effect. Mean hepatic blood flow decreased consistently by a mean of 17% (P less than 0.01) during propofol anaesthesia, and inconsistently during thiopentone anaesthesia so that it was not significantly different from baseline values. Mean renal blood flow decreased during propofol anaesthesia by 7% (P less than 0.05) and by 27% (P less than 0.001) during thiopentone anaesthesia. Whereas most variables returned to baseline values within 2 h after propofol anaesthesia, this took 5 h after thiopentone anaesthesia.
authors.affiliation: Department of Anaesthesia and Intensive Care, Flinders University of South Australia, Adelaide.
authors.forename: W B
authors.initials: WB
authors.lastname: Runciman
authors.forename: L E
authors.initials: LE
authors.lastname: Mather
authors.forename: D G
authors.initials: DG
authors.lastname: Selby
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008102:Liver Circulation / Q000187:drug effects; D008137:Longitudinal Studies; D010101:Oxygen Consumption; D015742:Propofol; D012079:Renal Circulation / Q000187:drug effects; D012756:Sheep; D013874:Thiopental; D013997:Time Factors
chemical_list: D013874:Thiopental; D015742:Propofol