Preferential activation and genotoxicity of food derived heterocyclic amine mutagens by recombinant cytochrome P4501A2.
Battula
N
N
Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892.
Townsend
G K
GK
Snyderwine
E G
EG
Schut
H A
HA
Thorgeirsson
S S
SS
D000588:Amines / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D005506:Food Contamination; D005822:Genetic Vectors; D006571:Heterocyclic Compounds / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics; D014616:Vaccinia virus / Q000235:genetics
D000588:Amines; D006571:Heterocyclic Compounds; D009153:Mutagens; D011994:Recombinant Proteins; D003577:Cytochrome P-450 Enzyme System