[The question of the transmissibility of the results of subcutaneous tests of biomaterials from animals to humans].
The histologic estimation of the subcutaneous connective-tissue reaction at implants forms an important part of the biocompatibility test. The connective-tissue capsulae around titanium implants in man, guinea-pig, and Wistar-rat were analysed by a special test system because of the question concerning the transmission of results of animal experiments on the man. The subsidence process of the thickness of the connective-tissue capsule and of the cell count per measuring fields were represented in dependence on the time. The findings showed the fundamental similar course of wound healing in man, guinea-pig, and Wistar-rat by the influence of an implant.
Schreiber
H
H
Institut für Gerichtliche Medizin, Bezirkskrankenhaus Gera, DDR.
Keller
F
F
Kinzl
H P
HP
Hunger
H
H
Knöfler
W
W
Rübling
U
U
Merten
W
W
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D002452:Cell Count; D003238:Connective Tissue / Q000473:pathology*; D005549:Foreign-Body Reaction / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D008422:Materials Testing; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D014025:Titanium / Q000009:adverse effects*
D001672:Biocompatible Materials; D014025:Titanium
Zur Frage der Ubertragbarkeit der Ergebnisse des Subkutantestes von Biomaterialien vom Tier auf den Menschen.