Effect of human epidermal growth factor (hEGF) on splanchnic circulation in dogs.
The effect of intravenous administration of human epidermal growth factor on the splanchnic blood flows was examined in anesthetized dogs, using an ultrasonic transit-time volume flow meter. Human epidermal growth factor (0.1, 0.5 and 1 microgram/kg) significantly increased blood flows in the portal vein (36.9 +/- 7.4% at 1 microgram/kg) and the superior mesenteric artery (49.0 +/- 16.8% at 1 microgram/kg). Systemic blood pressure monitored simultaneously was significantly decreased (8.4 +/- 1.2% at 1 microgram/kg). This study is the first to demonstrate that intravenous administration of epidermal growth factor increases the portal venous blood flow.
Sumi
S
S
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Inoue
K
K
Hosotani
R
R
Kogire
M
M
Doi
R
R
Yun
M
M
Higashide
S
S
Minote
H
H
Takaori
K
K
Kaji
H
H
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008638:Mesenteric Arteries; D011169:Portal Vein; D011994:Recombinant Proteins / Q000494:pharmacology; D013152:Splanchnic Circulation / Q000187:drug effects*
D011994:Recombinant Proteins; D004815:Epidermal Growth Factor