Effects of a new cholecystokinin antagonist (GE 410) on the smooth muscle of the guinea pig ileum.
Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-beta-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2 = 7.6, n = 0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons.
Rakovska
A
A
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Milenov
K
K
Henklein
P
P
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D002799:Cholinergic Fibers / Q000187:drug effects / Q000378:metabolism; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D012844:Sincalide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
C054261:succinyl-tyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenethylamide; D002766:Cholecystokinin; D012844:Sincalide; D000109:Acetylcholine