Extranodal T-cell lymphoma mimicking malignant histiocytosis.
We report a case of extranodal T-cell lymphoma with fever, hepatosplenomegaly, pancytopenia, and diffuse sinusoidal infiltration of the spleen, liver, and bone marrow by the tumor cells, mimicking malignant histiocytosis. This is the second case of T-gamma (T-cell suppressor) lymphoma resembling the case reported by Kadin et al. [N Engl J Med 304:648, 1981]. The lack of lymph node involvement in this case supports the theory that this type of lymphoma arises in the spleen. This paper draws attention to the extranodal T-cell lymphoma groups that mimic malignant histiocytosis and the need of immunophenotyping for a correct diagnosis. The causes for the absence of T-cell receptor gene rearrangement in T-cell tumors are discussed.
Sun
T
T
Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Brody
J
J
Susin
M
M
Lichtman
S
S
Boss
E
E
Moskowitz
L
L
D000328:Adult; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000276:immunology; D005434:Flow Cytometry; D005838:Genotype; D054747:Histiocytic Sarcoma / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000175:diagnosis*; D008297:Male; D010587:Phagocytosis; D013154:Spleen / Q000473:pathology / Q000648:ultrastructure