title: Atelectasis causes gas exchange impairment in the anaesthetised horse.
abstract: The anatomical basis of gas exchange impairment in the anaesthetised horse was studied by computerised tomography (CT; three shetland ponies) and morphological analysis (one pony and three horses). By means of CT, densities were seen in dependent lung regions early during anaesthesia, both with spontaneous breathing and with mechanical ventilation. The densities remained for some time where they had initially been created when the animal was turned from dorsal to sternal recumbency. Deep insufflation of the lungs reduced the dense area. Gas exchange was impaired roughly in proportion to the dense area. On histological analysis, the densities were atelectatic and congested with blood. Gravimetry showed no more extravascular water per unit lung tissue in the atelectatic than in the 'normal' regions, and the blood content was increased only slightly. It is concluded that the horse develops atelectasis in dependent lung regions early during anaesthesia in dorsal recumbency, and that atelectasis is the most likely explanation for the large shunt and impaired arterial oxygenation regularly seen during anaesthesia.
authors.affiliation: Department of Medicine, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
authors.forename: G
authors.initials: G
authors.lastname: Nyman
authors.forename: B
authors.initials: B
authors.lastname: Funkquist
authors.forename: C
authors.initials: C
authors.lastname: Kvart
authors.forename: C
authors.initials: C
authors.lastname: Frostell
authors.forename: L
authors.initials: L
authors.lastname: Tokics
authors.forename: A
authors.initials: A
authors.lastname: Strandberg
authors.forename: H
authors.initials: H
authors.lastname: Lundquist
authors.forename: B
authors.initials: B
authors.lastname: Lundh
authors.forename: B
authors.initials: B
authors.lastname: Brismar
authors.forename: G
authors.initials: G
authors.lastname: Hedenstierna
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary; D000818:Animals; D015633:Extravascular Lung Water / Q000737:chemistry; D005260:Female; D006734:Horse Diseases / Q000473:pathology / Q000503:physiopathology*; D006736:Horses; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood; D001261:Pulmonary Atelectasis / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D011659:Pulmonary Gas Exchange; D012119:Respiration; D012121:Respiration, Artificial / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D010100:Oxygen