[Effect of adrenergic beta receptor blockaders and thiazide diuretics on gastric acid and gastrin secretion in patients with essential hypertension].
The purpose of the study was to evaluate the effect of 6 weeks treatment with hydrochlorothiazide or propranolol on gastric acid and gastrin secretion in essential hypertension. The study was carried out in 10 patients receiving propranolol and 10 treated with hydrochlorothiazide. Acid and gastrin secretion were determined during histamine stimulation tests (Kay's test). Before the treatment the patients with essential hypertension were not significantly different from healthy controls with respect to acid secretion and gastrinemia profile after histamine stimulus. In both groups of patients no significant effect was observed of hypotensive treatment on basal acid output, but a significant inhibitory effect on gastrin secretion was noted. This effect was significantly greater in patients treated with propranolol than in the hydrochlorothiazide group. Moreover, in propranolol-treated patients a significant fall of histamine-induced acid secretion was found.
Zukowska-Szczechowska
E
E
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej w Katowicach.
Grzeszczak
W
W
Kokot
F
F
D000328:Adult; D000863:Antacids; D003864:Depression, Chemical; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*
D000863:Antacids; D005755:Gastrins; D006852:Hydrochlorothiazide; D011433:Propranolol
Wpływ leków blokujacych zakończenia beta-adrenergiczne oraz tiazydowych leków moczopednych na wydzielanie zoładkowe i sekrecje gastryny u chorych na samoistne nadciśnienie tetnicze.