[Morphological characteristics of the thymus gland of albino rats after prenatal administration of indomethacin].
By means of histological, histochemical and electron microscopical methods the thymus of white rat fetuses and offspring has been investigated during various age periods after indomethacin++ influence (2.5 mg/kg). In the fetuses retardation in separation of the gland parenchyma into lobules has been revealed. During the first two weeks of life the section area of the medulla decreases. Amount of lymphoid cells decreases; small and degenerating lymphocytes decrease in their number, while the part of lymphoblasts, middle lymphocytes and figures of mitosis increases. Enzymatic activity in the nervous structures of the organ is inhibited. Some essential disturbances of the intracellular structures are revealed; they demonstrate certain destructive changes. The data obtained show a decreasing function of the thymus after the prenatal influence of indomethacin++ during the first month of life, which is especially manifested during the first two weeks.
Morozova
E V
EV
Moiseeva
M L
ML
D000320:Adrenergic Fibers / Q000187:drug effects* / Q000648:ultrastructure; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology*; D002452:Cell Count / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000166:cytology / Q000187:drug effects* / Q000294:innervation / Q000648:ultrastructure; D007213:Indomethacin / Q000008:administration & dosage*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000294:innervation / Q000648:ultrastructure
D007213:Indomethacin
Morfologicheskie osobennosti timusa belykh krys v usloviiakh prenatal'nogo vozdeĭstviia indometatsina.