title: Development of a new inflow valve for a 20cc semisoft ventricle: preliminary results.
abstract: We remodeled and tested our semisoft 20cc ventricle and made a new bileaflet flap inflow valve. Housings, bases, outflow valve, and a newly designed diaphragm were all made by vacuum forming and put together by radiofrequency welding or glue. In vitro, the ventricle produced a cardiac output of 2.5 to 3.0 L/min and showed reliable durability results. Hematological testing showed no important thrombogenicity of the new valve. Cardiac output was higher than expected for the volume of the ventricle, perhaps because of stretching or flow through. Animal experiments with the left ventricular assist device (LVAD) version was done at Ohio State University. Earlier in Utah, we did 20 cc total artificial heart (TAH) implantations and LVAD experiments in lambs and recently in calves with the 60cc TAH version. A soft ventricle is easy to implant and low in production costs.
authors.affiliation: Willem J. Kolff's Laboratory, Department of Surgery, University of Utah, Salt Lake City.
authors.forename: E G
authors.initials: EG
authors.lastname: Wijsmuller
authors.forename: L S
authors.initials: LS
authors.lastname: Yu
authors.forename: B
authors.initials: B
authors.lastname: Yuan
authors.forename: N D
authors.initials: ND
authors.lastname: Bishop
authors.forename: W J
authors.initials: WJ
authors.lastname: Kolff
mesh_terms: D000818:Animals; D002417:Cattle; D004867:Equipment Design; D006350:Heart Valve Prosthesis; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D011140:Polyurethanes; D012756:Sheep
chemical_list: D011140:Polyurethanes