Susceptibility of Mastomys natalensis to Brugia malayi following pretreatment with antifilarials.
Mastomys natalensis pretreated with diethylcarbamazine (DEC), levamisole or centperazine were exposed to the standard inoculum of infective larvae of Brugia malayi. Percentage 'take' of infection, duration of prepatent period, course of microfilaraemia and number of adult worms recovered were compared with those of untreated infected Mastomys (control). DEC and centperazine did not alter the 'take' (DEC/centperazine: 100%; control: 88.24%) and the average prepatent period (DEC: 105.44 days; centperazine: 105.18 days, control: 109.20 days). In levamisole pretreated animals on the other hand, the 'take' was much lower (68.18%) with extended prepatent period (125.87 days). However, unlike centperazine and control, the course of microfilaraemia was identical in DEC and levamisole pretreated animals. The average adult worm recovery was significantly high in centperazine pretreated animals being 14.09 as against 8.12, 7.46 and 8.42 in DEC, levamisole pretreated and control animals, respectively.
Tyagi
K
K
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Murthy
P K
PK
Sen
A B
AB
D000818:Animals; D002009:Brugia / Q000254:growth & development / Q000276:immunology*; D004049:Diethylcarbamazine / Q000494:pharmacology / Q000627:therapeutic use; D004198:Disease Susceptibility; D004605:Elephantiasis, Filarial / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D005260:Female; D005369:Filaricides / Q000494:pharmacology / Q000627:therapeutic use*; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009115:Muridae; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use
D005369:Filaricides; D010879:Piperazines; C033224:centperazine; D007978:Levamisole; D004049:Diethylcarbamazine