[Ectericide as a dispersion medium for the preparation of prospective clinical liposomal drug forms].
The possibility of using ectericide, having antibacterial, detergent, antioxidative, and reparative effects, as a dispersion medium for liposome production has been studied. Its application allows for elaboration of a simplified liposome production technique simultaneously imparting them stability against oxidation, heating, and pH changes. A technology to produce multivesicular liposomes with ectericide++, containing rifampicin in the membranous envelope and gentamicin in the inner volume, has been developed. Liposomal antibiotics proved to be effective in clinical trials.
Dikiĭ
I L
IL
Strel'nikov
L S
LS
Chueshov
V I
VI
Iakovenko
V D
VD
Bazavluk
A D
AD
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006801:Humans; D066298:In Vitro Techniques; D008081:Liposomes / Q000138:chemical synthesis* / Q000627:therapeutic use; D013678:Technology, Pharmaceutical / Q000379:methods*; D014020:Tissue Extracts
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004337:Drug Carriers; D008081:Liposomes; D014020:Tissue Extracts; C014523:ectericide
Ekteritsid kak dispersionnaia sreda dlia polucheniia klinicheski perspektivnykh liposomal'nykh lekarstvennykh form.