title: [A possible molecular mechanism of the impairment of the stability of the genome in cells capable of replicating DNA in acute and chronic forms of radiation sickness].
abstract: On the basis of the experimentally grounded concept concerning the functional antagonism of various domains of chromosomal SSB-proteins, that play a major role in the implementation of the contrary processes which either provide stability of DNA macromolecules or bear the responsibility for their degradation, a possible molecular mechanism of the disturbance of cell genome stability upon acute and chronic radiation sickness is discussed.
authors.forename: G E
authors.initials: GE
authors.lastname: Fradkin
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004261:DNA Replication / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D008967:Molecular Biology; D011833:Radiation Injuries, Experimental / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins
vernacular_title: O vozmozhnom molekuliarnom mekhanizme narusheniia stabil'nosti genoma kletok, sposobnykh k replikatsii DNK pri ostroĭ i khronicheskoĭ formakh luchevoĭ bolezni