Correlates of rapid neuroleptic response in male patients with schizophrenia.
Correlates of neuroleptic response latency were assessed in 16 male schizophrenic inpatients during 4 weeks of fixed dose (20 mg/day) haloperidol treatment. Rapid responders showed a mean 40% reduction in Brief Psychiatric Rating Scale (BPRS) positive symptom scores by day 10 of treatment. Rapid responders had significantly lower plasma homovanillic acid (pHVA) concentrations compared to non-rapid responders during week 4 of haloperidol treatment. However, rapid versus non-rapid responders did not differ with respect to demographics, baseline positive or negative BPRS symptom scores, performance on tests of neuropsychological function, or mean plasma haloperidol concentrations.
Petrie
E C
EC
Schizophrenia Biologic Research Center, Department of Veterans Affairs Medical Center, Palo Alto, CA.
Faustman
W O
WO
Moses
J A
JA
Lombrozo
L
L
Csernansky
J G
JG
D000328:Adult; D006220:Haloperidol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D006220:Haloperidol; D006719:Homovanillic Acid