title: Biochemical evidence for the need of long-term mineral supplementation in an extremely low birth weight infant fed own mother's milk exclusively during the first 6 months of life.
abstract: In an extremely low birth weight infant fed expressed own mother's milk exclusively during the first 6 months of life, introduction of a human milk fortifier resulted in improvement of biochemical alterations consistent with metabolic bone disease of prematurity. Attempts to discontinue fortification at 9 weeks (discharge) and 21 weeks of age induced deterioration of biochemical parameters, demonstrating a persistent need for mineral supplementation during the whole period of breast-feeding. The effects of long-term human milk fortification are discussed.
authors.affiliation: Department of Neonatology, Children's Hospital, University of Düsseldorf, Federal Republic of Germany.
authors.forename: P
authors.initials: P
authors.lastname: Raupp
authors.forename: R
authors.initials: R
authors.lastname: von Kries
authors.forename: D
authors.initials: D
authors.lastname: Schmiedlau
authors.forename: F
authors.initials: F
authors.lastname: Manz
mesh_terms: D001851:Bone Diseases, Metabolic / Q000517:prevention & control*; D001942:Breast Feeding; D002136:Calcium, Dietary / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000097:blood / Q000378:metabolism*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood / Q000378:metabolism; D008297:Male; D008895:Milk, Human / Q000378:metabolism; D010758:Phosphorus / Q000008:administration & dosage / Q000097:blood* / Q000652:urine
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D010758:Phosphorus