title: Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins.
abstract: By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.
authors.affiliation: Department of Physiological Chemistry, University of Wisconsin, Madison 53706.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kang
authors.forename: J
authors.initials: J
authors.lastname: Ostermann
authors.forename: J
authors.initials: J
authors.lastname: Shilling
authors.forename: W
authors.initials: W
authors.lastname: Neupert
authors.forename: E A
authors.initials: EA
authors.lastname: Craig
authors.forename: N
authors.initials: N
authors.lastname: Pfanner
mesh_terms: D001692:Biological Transport; D002451:Cell Compartmentation; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D005656:Fungal Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D009154:Mutation; D011487:Protein Conformation; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins
chemical_list: D005656:Fungal Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D011498:Protein Precursors; D015800:Protozoan Proteins; C061945:mtp70 protein, Trypanosoma cruzi