[Influence of alcohol ingestion on plasma gastrin and CCK levels in human beings].
We investigated the time courses of the plasma ethanol, acetaldehyde, gastrin and cholecystokinin (CCK) levels after the ingestion of ethanol (1g/kg, 21.5%, whisky) in healthy male adult volunteers. The ethanol level reached a peak at 15 to 45 minutes after the ingestion and then decreased almost linearly. The acetaldehyde level of the group who became flushed after drinking (the F group) peaked earlier than that of the other group whose faces became only slightly flushed (the N group). The gastrin level increased significantly and remained elevated for about 3 hours. In three of the nine subjects, the CCK level increased 75 minutes after drinking. As a result, the absorption of the ingested ethanol is more rapid than 15 minutes, followed by a quick catabolism of the absorbed ethanol to acetaldehyde, but the catabolic action of acetaldehyde in the F group is later than that in the N group. The plasma gastrin level is certified to increase after the ingestion of ethanol and this is not mediated by acetaldehyde because the intra-venous infusion of acetaldehyde was not increased the plasma gastrin level in dogs. CCK which stimulate the pancreatic enzymes may be considered to have a possibility relating to the development of alcoholic acute pancreatitis but the ingestion of ethanol showed no increase of the plasma CCK level. But we cannot deny the possibility of the individual differences in the hormonal reaction in these experiments.
Yamaki
K
K
First Department of Surgery, Faculty of Medicine, Kyoto University.
Manabe
T
T
Tamura
K
K
Ando
K
K
Tobe
T
T
Kuwahara
C
C
Fukui
Y
Y
D000208:Acute Disease; D000328:Adult; D000428:Alcohol Drinking; D000818:Animals; D002766:Cholecystokinin / Q000097:blood*; D004285:Dogs; D000431:Ethanol / Q000493:pharmacokinetics; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D010195:Pancreatitis / Q000209:etiology
D005755:Gastrins; D000431:Ethanol; D002766:Cholecystokinin