[The effect of anti-arrhythmia agents on ventricular arrhythmias arising as a consequence of disorders in the myocardial blood supply].
The protective and therapeutic effects of some antiarrhythmic drugs of classes I-IV were studied in the experiments on 103 cats and 75 dogs. The antiarrhythmic drugs of classes 1a (N-propylaimaline bromide, aimaline, ethacizine), 1b (trimecaine) and IV (finoptine) were shown to prevent with various effectiveness the occurrence of early occlusion and reperfusion ventricular arrhythmias. The antiarrhythmic drugs of classes II (anapriline) and III (cordaron) proved to be ineffective in these cases. Ventricular arrhythmia in dogs occurring at the late stage of experimental infarction is reliably relieved in all cases with the antiarrhythmic drugs of class 1a, in most cases--those of classes 1b and III. The antiarrhythmic drugs of classes II and III are ineffective on this model. The experimental results analysed with regard to modern concepts of the genesis of modelled arrhythmias may be used as the experimental basis for a rational choice of antiarrhythmic drugs.
Gendenshteĭn
E I
EI
Kostin
Ia V
IaV
Markelova
N N
NN
Balashov
V P
VP
Oleĭnikov
V E
VE
Perevarin
A V
AV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents
Vliianie nekotorykh antiaritmicheskikh sredstv na zheludochkovye aritmii, voznikshie vsledstvie narusheniĭ krovosnabzheniia miokarda.