title: Expression of epidermal growth factor receptor in laryngeal dysplasia and carcinoma.
abstract: The immunoreactivity of epidermal growth factor receptor (EGFR) was studied in laryngeal biopsy specimens from 24 patients. The study comprised 5 cases of normal laryngeal mucosa, 5 cases of dysplasia, 7 cases of well differentiated squamous cell carcinoma, and 7 cases of poorly to moderately differentiated squamous cell carcinoma. EGFR was in general not expressed in normal and dysplastic epithelia, whilst all carcinomas showed a rather strong positive immunoreactivity. There was no significant difference in staining patterns between the well and poorly to moderately differentiated carcinomas. The results suggest that EGFR constitutes a component of neoplastic, but probably not preneoplastic, laryngeal disease. The study failed to reveal any difference in staining pattern between different types of laryngeal squamous cell carcinoma.
authors.affiliation: Department of Otolaryngology, Kagawa Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyaguchi
authors.forename: J
authors.initials: J
authors.lastname: Olofsson
authors.forename: H B
authors.initials: HB
authors.lastname: Hellquist
mesh_terms: D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007820:Laryngeal Mucosa / Q000378:metabolism / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D066246:ErbB Receptors