title: Antilipidemic agents, III: Synthesis of some heterocyclic derivatives of beta-sitosterol.
abstract: Four novel series of heterocyclic derivatives of beta-sitosterol were prepared by the reaction of 3-beta-sitosterol hemisuccinate with SOCl2 then with thiols, amines or phenols. These series are: 3 beta-[(3-substituted-4(3H)-quinazolinon-2- yl)thiocarbonylproprionyloxy]stigmast-5-ene; 3 beta- ([4-substituted-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl] thiocarbonylpropionyloxy)stigmast-5-ene; 3 beta- [(5-substituted-1,3,4-thiadiazol-2-yl)carbamoylpropionyloxy] stigmast-5-ene and 3 beta-(substituted carbamoyl or oxycarbonylpropionyloxy)stigmast-5-ene. The antilipidemic activity of representative compounds was studied.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
authors.forename: N S
authors.initials: NS
authors.lastname: Habib
authors.forename: M A
authors.initials: MA
authors.lastname: Khalil
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D051379:Mice; D012855:Sitosterols / Q000138:chemical synthesis*
chemical_list: D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D012855:Sitosterols