Biologically based models for risk assessment.
The modelling problems associated with the estimation of risks from long-term chemical exposures at low dose levels represent a statistical and mathematical challenge with special relevance to environmental research. Determining an adequate model for estimating the relationship between dose and response is critical to reducing potential bias in the risk estimation process. This paper discusses the various assumptions and models used in carcinogenic risk assessment. The emphasis is on our ability to accurately determine the magnitude of the carcinogenic risk, the shape of the dose-response relationship and the overall variability of the risk estimates.
Portier
C J
CJ
Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Hoel
D G
DG
Kaplan
N L
NL
Kopp
A
A
D000818:Animals; D002274:Carcinogens, Environmental; D004260:DNA Repair; D006801:Humans; D008452:Maximum Allowable Concentration; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced*; D012306:Risk
D002274:Carcinogens, Environmental