[Immunohistology of polyps of the nose and paranasal sinuses. Physiopathologic value].
The pathophysiology of nasal polyposis is yet unclear, but chronic disturbances of the inflammatory pathways may be suspected. Immunological investigations were performed in 3 series of patients: 37 with nasal polyps, 22 with chronic sinusitis, and 15 controls with healthy nasal and sinusal mucosa. Patients with nasal polyps had up to ten times more eosinophil density than patients with sinusitis or healthy mucosa. The average of mast cells and IgE or IgA, M, G plasma cells were not different in the various group. Deposited immune complexes were always absent. These results gave us the opportunity to discuss recent pathogenic theories.
Jankowski
R
R
Service ORL, CHR, Nancy.
Wayoff
M
M
Faure
G
G
Moneret-Vautrin
D A
DA
Bene
M C
MC
Simon
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D004804:Eosinophils / Q000737:chemistry / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008407:Mast Cells / Q000737:chemistry / Q000276:immunology; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis* / Q000503:physiopathology; D010254:Paranasal Sinus Diseases / Q000175:diagnosis* / Q000503:physiopathology; D010950:Plasma Cells / Q000737:chemistry / Q000276:immunology; D012852:Sinusitis / Q000175:diagnosis*
D007136:Immunoglobulins
Etude immuno-histologique de la polypose nasosinusienne. Intérêt physio-pathologique.