title: [Free amino acids of the liver and the characteristics of the amino acid metabolism in the liver and brain after cyanamide administration to rats].
abstract: A single administration to rats of cyanamide (60 mg/kg, for 1 hour) was found to decrease the contents of cysteate, serine, glutamate, glycine, alanine, valine, methionine, isoleucine, tyrosine, ethanolamine, ornithine and histidine that may be considered as a manifestation on the drug hepatotoxicity. The activities of transaminases, glutamate dehydrogenase, pyruvate dehydrogenase remained unchanged. Cyanamide effects were considerably abolished by the supplementary ethanol administration (0.5 g/kg). Cyanamide failed to affect vitamin-dependent enzymes reflecting thiamine pyrophosphate, pyridoxal phosphate and flavine adenine dinucleotide status of the rat organism.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Ostrovskiĭ
authors.forename: B I
authors.initials: BI
authors.lastname: Gorenshteĭn
authors.forename: G A
authors.initials: GA
authors.lastname: Dosta
authors.forename: L M
authors.initials: LM
authors.lastname: Karaedova
authors.forename: L I
authors.initials: LI
authors.lastname: Nefedov
mesh_terms: D000596:Amino Acids / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003484:Cyanamide / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats
chemical_list: D000596:Amino Acids; D000431:Ethanol; D003484:Cyanamide
vernacular_title: Svobodnye aminokisloty pecheni i osobennosti obmena aminokislot pecheni i mozga pri vvedenii tsiamida krysam.