title: Glucose utilization by skeletal muscles in vivo in experimental hyperthyroidism in the rat.
abstract: In the fed state, hyperthyroidism increased glucose utilization indices (GUIs) of skeletal muscles containing a lower proportion of oxidative fibres. Glycogen concentrations were unchanged, but active pyruvate dehydrogenase (PDHa) activities were decreased. Hyperthyroidism attenuated the effects of 48 h of starvation to decrease muscle GUI. Glycogen concentrations and PDHa activities after 48 h of starvation were low and similar in euthyroid and hyperthyroid rats. The increase in glucose uptake and phosphorylation relative to oxidation and storage in skeletal muscle induced by hyperthyroidism may contribute to increased glucose re-cycling in the fed hyperthyroid state and to glucose turnover in the starved hyperthyroid state.
authors.affiliation: Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London, U.K.
authors.forename: M C
authors.initials: MC
authors.lastname: Sugden
authors.forename: Y L
authors.initials: YL
authors.lastname: Liu
authors.forename: M J
authors.initials: MJ
authors.lastname: Holness
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005502:Food; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006980:Hyperthyroidism / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D009132:Muscles / Q000378:metabolism*; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000150:complications / Q000378:metabolism; D014284:Triiodothyronine
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D014284:Triiodothyronine; D019289:Pyruvic Acid; D006003:Glycogen; D005947:Glucose