Function of kidney grafts from brain-dead donor pigs. The influence of dopamine and triiodothyronine.
There are conflicting reports about the effects of administration of dopamine to brain-dead donors upon posttransplant organ function. This study compared the survival and serum creatinine levels in pigs that received renal grafts from untreated controls, from controls in which either the donor or donor and recipient received dopamine or from animals rendered brain dead for 16 hr by acute elevation of intracranial pressure, and given standard supportive treatment. In two additional groups, brain-dead donors were given dopamine or dopamine with triiodothyronine. Recipients of grafts from control animals or from brain-dead donors survived the 7-day period of study and showed minimal changes in serum creatinine. Recipients of grafts from brain-dead donors given dopamine however showed reduced survival and progressive increase in serum creatinine. This did not occur in the group given triiodothyronine concurrently with dopamine. It is suggested that if administration of dopamine is essential to treat donor hypotension, concurrent use of triiodothyronine may preserve posttransplant renal function.
Pienaar
H
H
Department of Surgery, University of Cape Town, Observatory, South Africa.
Schwartz
I
I
Roncone
A
A
Lotz
Z
Z
Hickman
R
R
D000818:Animals; D001926:Brain Death / Q000503:physiopathology*; D003404:Creatinine / Q000097:blood; D004298:Dopamine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D016030:Kidney Transplantation; D013552:Swine; D014019:Tissue Donors; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D003404:Creatinine; D004298:Dopamine