title: [Triclabendazole (Fasinex) residue in milk: determination and excretion kinetics].
abstract: The determination of triclabendazole (Fasinex) in milk is described. The excretion of triclabendazole and its two main metabolites was measured under field conditions in twenty-five cows. Triclabendazole was administered to cows in a dosage of approximately 12 mg kg-1. The maximum concentration of the main metabolites of triclabendazole (triclabendzole sulphone) measured in milk was 1.415 mg/l. Metabolites could be detected in milk during a ten-day-period. Only 1.5% (maximum) of the triclabendazole administered was eliminated as triclabendazole sulphone by way of milk.
authors.affiliation: Gezondheidsdienst voor Dieren in Overijssel en Flevoland, Zwolle.
authors.forename: G H
authors.initials: GH
authors.lastname: Counotte
authors.forename: A
authors.initials: A
authors.lastname: Reimink
authors.forename: B
authors.initials: B
authors.lastname: Redder
authors.forename: H
authors.initials: H
authors.lastname: Hasselt
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000032:analysis*; D001562:Benzimidazoles / Q000032:analysis* / Q000493:pharmacokinetics / Q000652:urine; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D008892:Milk / Q000737:chemistry*; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole
vernacular_title: Triclabendazol (Fasinex)-residuen in melk: bepaling en uitscheidingskinetiek.