[Mechanisms of organic drug electrophoresis].
Riboflavin, riboflavin mononucleotide, and fluorescein penetration from the ocular bath without electric current (control), from the anode, from the cathode, and without current after preliminary galvanization was studied in rabbit eyes. Penetration of organic drugs into intraocular fluid in electrophoresis was found to be increased not only from the adequate pole of the active electrode, but from the contrary pole as well. Galvanic current sharply abated the barrier function of the cornea. Therapeutic electrophoresis of the eyeball permits the use of many-component solutions with drug ions of different charge.
Nuritdinov
V A
VA
D000818:Animals; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005486:Flavin Mononucleotide / Q000008:administration & dosage / Q000378:metabolism; D005452:Fluoresceins / Q000008:administration & dosage / Q000378:metabolism; D007478:Iontophoresis; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D011817:Rabbits; D012256:Riboflavin / Q000008:administration & dosage / Q000378:metabolism
D005452:Fluoresceins; D004364:Pharmaceutical Preparations; D005486:Flavin Mononucleotide; D012256:Riboflavin
Nekotorye zakonomernosti élektroforeza organicheskikh lekarstvennykh veshchestv.