title: A mixed Australian fish diet and fish-oil supplementation: impact on the plasma lipid profile of healthy men.
abstract: Twelve healthy men were fed in turn three diets for 6 wk each in a 3 x 3 randomized block design: a control diet (essentially fish free), a fish diet (200 g lean Australian fish flesh/d), and the same fish-based meal but supplemented with 5 g fish oil/d. Dietary eicosapentaenoic acid [EPA, 20: 5n-3 (omega-3)] was strongly associated with erythrocyte membrane EPA (r = 0.908 at 6 wk), strengthening its value as a measure of compliance in fish and fish-oil feeding trials. On the fish diet, subjects had increased incorporation of n-3 polyunsaturated fatty acids (PUFAs) at the expense of n-6 PUFAs in their erythrocyte membranes. When the fish-based diet was supplemented with fish oil (5 g/d), there was a significant lowering of plasma triacylglycerol (-0.16 +/- 0.24 mmol/L; mean +/- SD). No change in plasma total cholesterol was detected although the fish + oil diet produced a reduction in very-low-density-lipoprotein cholesterol (-0.24 +/- 0.26 mmol/L).
authors.affiliation: Department of Biochemistry, University of Sydney, NSW, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Brown
authors.forename: D C
authors.initials: DC
authors.lastname: Roberts
authors.forename: J E
authors.initials: JE
authors.lastname: Pritchard
authors.forename: A S
authors.initials: AS
authors.lastname: Truswell
mesh_terms: D000328:Adult; D000818:Animals; D000886:Anthropometry; D001315:Australia; D004032:Diet; D015930:Diet Records; D005395:Fish Oils / Q000494:pharmacology*; D005399:Fishes; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides