title: Must clinical trials be large? The interpretation of P-values and the combination of test results.
abstract: The notion that small, well planned clinical trials may not be worth undertaking is shown to arise from an overemphasis on just one way of interpreting P-values. Alternative forms of P and other interpretations are put forward. Attention is drawn to some aspects of the theory of hypothesis testing which seem less well known than they should be.
authors.affiliation: University of Essex, Wivenhoe Park, Colchester, U.K.
authors.forename: G A
authors.initials: GA
authors.lastname: Barnard
mesh_terms: D016010:Binomial Distribution; D002986:Clinical Trials as Topic / Q000379:methods*; D011336:Probability; D012107:Research Design; D013223:Statistics as Topic