[The immunomodulation of the natural killer activity of the splenocytes in C3HA mice during hepatoma 22a growth].
A single injection of C3HA mice with various immunomodulators-ds-RNA, thymogene (TM) and cyclophosphamide (CY)--performed one day before transplantation of syngeneic hepatoma 22a cells led to a decrease in the tumor growth rate. The most prominent effect was found following the CY treatment. The NK cell activity estimated per spleen of mice treated with ds-RNA and TM was seen increased in comparison with the control mice not given the modulators. The rate of tumor growth was due probably to this fact. The protective effect of CY may be accounted for by a direct action of this agent on tumor cells.
Filatova
N A
NA
Malygin
A M
AM
Goriunova
L B
LB
Fel'
V Ia
VIa
Khavinson
V Kh
VKh
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D003601:Cytotoxicity Tests, Immunologic; D004151:Dipeptides; D004354:Drug Screening Assays, Antitumor; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D009368:Neoplasm Transplantation; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D012330:RNA, Double-Stranded / Q000494:pharmacology / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; D012330:RNA, Double-Stranded; C060736:thymogen; D003520:Cyclophosphamide
Immunomoduliatsiia estestvennoĭ killernoĭ aktivnosti splenotsitov mysheĭ C3HA v usloviiakh rosta gepatomy 22a.