[The prodigiozan and pyrogenal stimulation of the humoral response to influenza virus antigens in mice].
The adjuvant properties of prodigiosan and pyrogenal, lipopolysaccharides of medical importance, were studied. Prodigiosan inoculated to mice together with influenza virus was found, on the one hand, to increase 10-fold the titer of specific antibodies and, on the other, to allow to reduce the antigen dose 50-fold or more. No adjuvant properties of pyrogenal were observed under the experimental conditions.
Khromov
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IS
Isaeva
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EI
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D011354:Prodigiozan / Q000494:pharmacology*; D011749:Pyrogens / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000914:Antibodies, Viral; D000956:Antigens, Viral; D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D011354:Prodigiozan
Stimuliatsiia prodigiozanom i pirogenalom gumoral'nogo otveta na antigeny virusa grippa u mysheĭ.