title: Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations.
abstract: A significant increase in the incidence of structural chromosome anomalies has been observed in the sperm of patients treated with radio and/or chemotherapy for different types of cancer when analyzed by the interspecific fertilization of hamster eggs. The analysis of these aberrations shows that while in controls only 9.4% of structural abnormalities are of the stable type, in treated patients this figure increases to 39.3%, thus indicating that the anomalies have not been produced during the fertilization of the hamster egg. However, it is possible that part, or even most, of the breaks appear as a result of a reduced repair capacity of sperm chromosomes in the cytoplasm of the hamster egg.
authors.affiliation: Departament de Biologia Cellular i Fisiologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Genescà
authors.forename: J
authors.initials: J
authors.lastname: Benet
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: J R
authors.initials: JR
authors.lastname: Germà
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002869:Chromosome Aberrations; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*
chemical_list: D000970:Antineoplastic Agents