title: [Relation of tumor number to clinical course of superficial papillary bladder tumors].
abstract: Clinical courses of 293 patients with superficial papillary bladder tumors were analysed on the basis of tumor number at the first presentation. The follow-up period ranged from 6 to 266 months with a median of 59 months. 171 patients (58%) had a single tumor, while 122 (42%) had multiple tumors. Those older than 60 years occupied 68% in the latter group and 51% in the former (p less than 0.01). High grade tumors were more frequent in the latter than the former (p less than 0.05). The five-year recurrence rate was 68% for the latter and 39% for the former single tumor group (p less than 0.01). Malignant progression was observed in 3.6% of patients with a single tumor and 13.4% of those with multiple tumors (p less than 0.01). The results would offer a theoretical background to the finding of a poor ten-year actuarial survival rate of 54% for multiple tumor group compared with 76% for the single tumor group (p less than 0.05). However, the rate of primary cancer death was similar in both groups.
authors.affiliation: Department of Urology, Tokyo Medical and Dental University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Sumi
authors.forename: I
authors.initials: I
authors.lastname: Fukui
authors.forename: H
authors.initials: H
authors.lastname: Sekine
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Kihara
authors.forename: A
authors.initials: A
authors.lastname: Noro
authors.forename: H
authors.initials: H
authors.lastname: Oshima
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery