Influence of general anaesthesia (thiopental sodium) on progesterone and cortisol levels in pregnant goat serum.
6 pregnant Baladi goats underwent general anaesthesia, using thiopental sodium. Intravenous application of 10-15 mg/kg body weight of thiopental sodium in 2.5% solution produced light anaesthesia for about 20 minutes. The effect of general anaesthesia on progesterone and cortisol levels was studied before and during the application of anaesthesia as well as 1/2, 1, 4, and 24 hours after anaesthesia. Progesterone was determined by RIA and cortisol by competitive protein binding reaction. Decrease in progesterone and rise in cortisol were noticed during and after anaesthesia. 4 of 13 foetuses were aborted 1-2 weeks after the application of anaesthesia. 6 were born dead. 2 died few hours after birth, and 1 stayed alive.
Eissa
H M
HM
Faculty of Veterinary Medicine, Department of Surgery and Theriogenology, Cairo University, Giza, Egypt.
Ahmed
A S
AS
Serur
B H
BH
el-Sayed
M A
MA
D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D005260:Female; D006041:Goats / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011374:Progesterone / Q000097:blood*; D013874:Thiopental
D011374:Progesterone; D013874:Thiopental; D006854:Hydrocortisone