title: Activity of compound G2 isolated from alfalfa roots in experimental dermatophyte infection.
abstract: Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of the untreated lesions which healed spontaneously (P less than 0.01).
authors.affiliation: Department of Dermatology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Evron
authors.forename: M
authors.initials: M
authors.lastname: Guizie
authors.forename: U
authors.initials: U
authors.lastname: Zehavi
authors.forename: I
authors.initials: I
authors.lastname: Polacheck
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D008253:Macaca mulatta; D000455:Medicago sativa / Q000032:analysis*; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014315:Triterpenes; C049077:medicagenic acid-3-O-glucopyranoside