Prednisolone and danazol for treatment of immune-mediated anemia, thrombocytopenia, and ineffective erythroid regeneration in a dog.
Immune-mediated anemia and thrombocytopenia were diagnosed in an 8-year-old spayed Miniature Schnauzer. The initial CBC indicated poor erythroid regeneration and concurrent leukopenia. The results of a Coombs test and ANA titer were strongly positive. Examination of a bone marrow specimen revealed erythrophagocytosis and a maturation arrest in the RBC series. Treatment with transfusion plus prednisolone and an attenuated androgen (danazol) resulted in stabilization of the PCV and the development of reticulocytosis.
Holloway
S A
SA
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Meyer
D J
DJ
Mannella
C
C
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D003613:Danazol / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D015672:Erythroid Precursor Cells / Q000502:physiology; D005260:Female; D011239:Prednisolone / Q000627:therapeutic use*; D012156:Reticulocytes / Q000502:physiology; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
D011239:Prednisolone; D003613:Danazol