Urinary organic acid excretion during feeding of medium-chain or long-chain triglyceride diets in patients with non-insulin-dependent diabetes mellitus.
Medium-chain triglycerides (MCTs) are absorbed and metabolized differently from long-chain triglycerides (LCTs). Recent data indicate that MCTs may be useful as a dietary substitute in a variety of clinical disorders. The current studies were undertaken to characterize urinary organic acid excretion in patients with non-insulin-dependent diabetes mellitus during 4 d of an LCT or MCT diet. Urinary excretion of the dicarboxylic acids adipic, suberic, and 3-hydroxysebacic and the (omega-1) hydroxylation products 5-hydroxyhexanoic acid and 7-hydroxyoctanoic acid, was increased during MCT feeding as compared with LCT feeding. Urinary suberic and 7-hydroxyoctanoic acid excretions were increased 55- and 30-fold, respectively, during the MCT-substituted diet. Urinary organic acid profiles provide information on the fate of lipids during MCT feeding and may also be useful in assessing complicance during clinical trials employing MCT-substituted diets.
Brass
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Department of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Tserng
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Eckel
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D002208:Caproates / Q000652:urine; D002210:Caprylates / Q000652:urine; D002264:Carboxylic Acids / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003998:Dicarboxylic Acids / Q000652:urine; D005260:Female; D005526:Food, Formulated / Q000032:analysis; D006801:Humans; D006880:Hydroxy Acids; D008297:Male; D014280:Triglycerides / Q000008:administration & dosage* / Q000032:analysis / Q000145:classification / Q000378:metabolism
D002208:Caproates; D002210:Caprylates; D002264:Carboxylic Acids; D003998:Dicarboxylic Acids; D006880:Hydroxy Acids; D014280:Triglycerides; C016502:5-hydroxyhexanoic acid