[The effect of moderate oxygen deficiency on volume regulation in man].
In acute hypoxia or at pharmacological stimulation of the peripheral arterial chemoreceptors by almitrine, a transient natriuresis and diuresis occurs. Depending on the starting level, e.g. on the state of water diuresis or the osmotic diuresis, the renal excretion responded differently in our examinations. In water diuresis the water excretion increased isolatedly. In the opposite to the osmotic diuresis, the natriuresis did not increase. This response might be based on the proximal inhibition of the sodium and water reabsorption at following augmented distal sodium reabsorption and suppressed distal water reabsorption. In this way the organism is able to respond with increased water excretion at sodium excretion kept constant or with diuresis and natriuresis when arterial chemoreceptors are stimulated.
Quies
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W
Institut für Physiologie des Bereiches Medizin Ernst-Moritz-Arndt-Universität, Greifswald.
Ledderhos
C
C
D000328:Adult; D015765:Almitrine / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects; D004231:Diuresis / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D009318:Natriuresis / Q000502:physiology*; D009994:Osmolar Concentration
D015765:Almitrine
Zur Wirkung eines moderaten Sauerstoffmangels auf die Volumenregulation des Menschen.