title: Isolation of urinary p-hydroxylated metabolites of mephentermine and phentermine in male Wistar rats.
abstract: 1. p-Hydroxymephentermine (p-hydroxy-MP) and p-hydroxyphentermine (p-hydroxy-Ph) were isolated as hydrochlorides from urine of male Wistar rats repeatedly dosed with mephentermine (MP). In addition, p-hydroxy-Ph was isolated as the hydrochloride from urine of the rats dosed with phentermine (Ph). 2. These results substantiate previous indications that p-hydroxylation of MP and Ph was a primary metabolic reaction in the rat.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: M A
authors.initials: MA
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Uy-Yu
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Miyahara
authors.forename: H
authors.initials: H
authors.lastname: Kozuka
mesh_terms: D000814:Aniline Compounds / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008616:Mephentermine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000652:urine*; D010645:Phentermine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000814:Aniline Compounds; C066111:4-hydroxymephentermine; C066212:2-fluoroaniline; C066112:4-hydroxyphentermine; D010645:Phentermine; D008616:Mephentermine