[Intraocular penetration of topical norfloxacin in humans. Preliminary study].
The aim of this bicentric study was to assess the intraocular penetration of topical Norfloxacin. Herein, are only reported the results from one center. Topically applied Norfloxacin 0.3% was given to patients who underwent cataract surgery. The first group received 5 drops between 7.55 A.M. to 8 A.M. and after each hour until cataract surgery. The second one received one drop each quarter from 7 A.M. until the surgery. Aqueous and sera samples were dosed using HPLC. In the first group, the aqueous average was 0.066 mg/l and 0.112 mg/l in the second group. Using a T test and Mann Whitney test, we could not find a significant difference between the two groups.
Bron
A
A
Service d'Ophtalmologie de Dijon, Hôpital Général.
Pechinot
M
M
Chirpaz
L
L
Razakarivony
H
H
Kamcierkzak
A
A
Adenis
J P
JP
D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions
D009883:Ophthalmic Solutions; D009643:Norfloxacin
Pénétration intra-camérulaire de la norfloxacine locale chez l'homme. Etude préliminaire.