title: Orofacial granulomatosis associated with delayed hypersensitivity to cobalt.
abstract: Orofacial granulomatosis is a distinct clinical and pathological entity characterized by swelling of the lips and lower half of the face. Ulceration of the oral mucosa may also occur. Granulomas are seen histologically. Orofacial granulomatosis may occur in the Melkersson-Rosenthal syndrome, granulomatous cheilitis of Miescher, oral Crohn's disease, sarcoidosis and focal dental sepsis. The increased prevalence of atopy in patients with orofacial granulomatosis and the association with food intolerance suggests the possibility of a role for allergy in at least some cases.
authors.affiliation: Department of Dermatology, Royal Liverpool Hospital, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Pryce
authors.forename: C M
authors.initials: CM
authors.lastname: King
mesh_terms: D002648:Child; D003035:Cobalt / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D005881:Gingiva / Q000293:injuries*; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006184:Habits; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000473:pathology; D008046:Lip / Q000473:pathology; D008047:Lip Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
chemical_list: D003035:Cobalt