Metabolic effects induced by L-carnitine and propionyl-L-carnitine in human hypoxic muscle tissue during exercise.
An experimental model was developed to investigate some metabolic effects of strenuous exercise in hypoxic muscle tissue of human volunteers. The incidence of carnitine supplementation was studied, assuming as marker the thiobarbituric acid reaction products analysed in plasma samples collected during the course of the protocol programme. Propionyl-L-carnitine appears to antagonize in a significant degree the damaging effects of muscle fatigue combined with hypoxic status. Under these conditions the detoxifying role played by propionyl-L-carnitine, previously reported in various tissues and in other pathological conditions, appears to be relevant, although further studies are needed to elucidate the pharmacodynamics of this molecule.
Corbucci
G G
GG
Institute of Anaesthesia/Resuscitation, University of Cagliari, Italy.
Montanari
G
G
Mancinelli
G
G
D'Iddio
S
S
D002331:Carnitine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000209:etiology; D008054:Lipid Peroxides / Q000097:blood; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D005082:Physical Exertion; D013997:Time Factors
D008054:Lipid Peroxides; C003223:propionylcarnitine; D002331:Carnitine