title: Prednisolone and danazol for treatment of immune-mediated anemia, thrombocytopenia, and ineffective erythroid regeneration in a dog.
abstract: Immune-mediated anemia and thrombocytopenia were diagnosed in an 8-year-old spayed Miniature Schnauzer. The initial CBC indicated poor erythroid regeneration and concurrent leukopenia. The results of a Coombs test and ANA titer were strongly positive. Examination of a bone marrow specimen revealed erythrophagocytosis and a maturation arrest in the RBC series. Treatment with transfusion plus prednisolone and an attenuated androgen (danazol) resulted in stabilization of the PCV and the development of reticulocytosis.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
authors.forename: S A
authors.initials: SA
authors.lastname: Holloway
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyer
authors.forename: C
authors.initials: C
authors.lastname: Mannella
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D003613:Danazol / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D015672:Erythroid Precursor Cells / Q000502:physiology; D005260:Female; D011239:Prednisolone / Q000627:therapeutic use*; D012156:Reticulocytes / Q000502:physiology; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D011239:Prednisolone; D003613:Danazol