Topical antiinflammatory effects of Euphorbia prostrata on carrageenan-induced footpad oedema in mice.
The ethyl acetate extract and a fraction, KSE-23, isolated chromatographically from the ethyl acetate extract of Euphorbia prostrata, showed significant antiinflammatory activity when topically applied in a murine model of carrageenan footpad oedema. KSE-23 was found to be more potent than indomethacin given in the same manner.
Singla
A K
AK
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Pathak
K
K
D000085:Acetates; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; C007650:ethyl acetate; D002351:Carrageenan; D007213:Indomethacin