title: Early complications after surgery for Crohn's disease.
abstract: A group of 212 patients operated upon for Crohn's disease were studied and the early postoperative complications with related problems were assessed. The morbidity was 28.3 per cent, 60 patients had at least one complication, mainly of septic nature. The mortality was 3.3 per cent (7 patients), sepsis and deep vein thrombosis with pulmonary embolism were the most common causes of death. Postoperative complications were significantly higher (39.7%) (p less than 0.001) in patients with a pre-operative nutritional deficit and in those who had urgent surgery (44.4%) (p less than 0.001). Among patients with pre-operative sepsis, the morbidity was also higher (34.6%), but was not significant. Peri-anastomotic complications (dehiscence, abscess, fistula, bleeding) were apparently more frequent (45.4%) in patients with histological residual Crohn's disease at macroscopically free resection margins although this contrasts with previous series. A proper pre-operative diagnostic approach, adequate peri-operative protein-caloric repletion, antibiotic therapy, prevention of thromboembolism and elective surgery, are still the primary tools in reducing the morbidity and mortality after surgery for Crohn's disease.
authors.affiliation: Surgical Clinic, University of L'Aquila, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Simi
authors.forename: S
authors.initials: S
authors.lastname: Leardi
authors.forename: S
authors.initials: S
authors.lastname: Minervini
authors.forename: R
authors.initials: R
authors.lastname: Pietroletti
authors.forename: M
authors.initials: M
authors.lastname: Schietroma
authors.forename: V
authors.initials: V
authors.lastname: Speranza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016009:Chi-Square Distribution; D002648:Child; D003092:Colitis / Q000401:mortality / Q000601:surgery; D003424:Crohn Disease / Q000401:mortality / Q000601:surgery*; D004630:Emergencies; D005260:Female; D006801:Humans; D007079:Ileitis / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents