title: [Normogenesis of the cornea and its modification by cyclophosphamide in the animal experiment].
abstract: Animal experiments serving as models have hitherto been indispensable in order to explain pathogenetic processes in the development of malformations. The results presented here are contribution to studies on the normogenesis of the cornea in defined animal material (albino mice of Agnes Bluhm Jena-Halle stock). A single application of cyclophosphamide during embryogenesis caused inhibition malformations. Of these, different degrees of corneal hypoplasia and Peters' malformation are discussed in detail.
authors.affiliation: Klinik und Poliklinik für Augenkrankheiten des Bereiches Medizin, Martin-Luther-Universität Halle-Wittenberg.
authors.forename: M
authors.initials: M
authors.lastname: Tost
authors.forename: F
authors.initials: F
authors.lastname: Tost
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D003315:Cornea / Q000166:cytology*; D003319:Corneal Stroma / Q000166:cytology; D003520:Cyclophosphamide / Q000633:toxicity*; D004728:Endothelium, Corneal / Q000166:cytology; D004847:Epithelial Cells; D005260:Female; D005865:Gestational Age; D007908:Lens, Crystalline / Q000166:cytology; D051379:Mice; D011247:Pregnancy
chemical_list: D003520:Cyclophosphamide
vernacular_title: Zur Normogenese der Hornhaut und ihrer Beeinflussung durch Cyclophosphamid im Tierexperiment.