[Clinical studies on hyperuricemia and gout after transplantation].
We performed renal transplantation on 67 patients (living 37, cadaver 30) between November 1975 and December 1987. Twenty-seven of the 67 patients had hyperuricemia (serum uric acid: male greater than or equal to 8.0 mg/dl, female greater than or equal to 7.0 mg/dl) and 2 of them had episodes of gout. However, there was no correlation between serum creatinine and uric acid in 27 hyperuricemic patients. Twelve of 27 hyperuricemic patients were treated with either allopurinol or benzbromarone. These therapies were effective for 9 of them and serum uric acid level controlled well. One of 2 gouty patients developed gout 4 years after cadaveric renal transplantation. She was treated with anodyne and benzbromarone for gout. These treatments were effective and she has been in good condition. We consider it necessary to treat hyperuricemia after renal transplantation and to control serum uric acid well.
Imanishi
M
M
Department of Urology, Kinki University School of Medicine.
Ikegami
M
M
Ishii
T
T
Nishioka
T
T
Uemura
T
T
Kunikata
S
S
Kanda
H
H
Matsuura
T
T
Akiyama
T
T
Kurita
T
T
D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D001553:Benzbromarone / Q000627:therapeutic use; D005260:Female; D006073:Gout / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D014527:Uric Acid / Q000097:blood*
D000700:Analgesics; D007166:Immunosuppressive Agents; D014527:Uric Acid; D001553:Benzbromarone; D000493:Allopurinol