Characteristics of participants at baseline in the Treatment of Mild Hypertension Study (TOMHS).
The Treatment of Mild Hypertension Study (TOMHS) is a randomized, double-blind clinical trial currently being conducted to compare the effects of nonpharmacologic therapy alone with those of 1 of 5 active drug regimens combined with nonpharmacologic therapy, for long-term management of patients with mild hypertension. Six classes of drugs were studied: (1) acebutolol (beta blocker), (2) amlodipine (calcium antagonist), (3) chlorthalidone (diuretic), (4) doxazosin (alpha 1 antagonist), (5) enalapril (angiotensin-converting enzyme inhibitor) and (6) placebo. All participants received nutritional-hygienic advice to reduce weight and sodium and alcohol intakes and to increase physical activity. End points include blood pressure change, side effects and quality-of-life indices; incidence of electrocardiographic and echocardiographic abnormalities; and incidence of cardiovascular clinical events, including death, among participants receiving drugs as first-step treatment as well as nonpharmacologic treatment compared with incidence among those participants randomized to nonpharmacologic treatment only as the initial step.
Mascioli
S R
SR
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55455.
Grimm
R H
RH
Neaton
J D
JD
Stamler
J
J
Prineas
R J
RJ
Cutler
J A
JA
Elmer
P J
PJ
McDonald
R
R
Schnaper
H
H
Schoenberger
J
J
D000368:Aged; D000428:Alcohol Drinking; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use; D001794:Blood Pressure; D004039:Diet, Sodium-Restricted; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
D000959:Antihypertensive Agents