The theoretical implications and experimental and clinical results of radiolabeled antiferritin.
Ferritin is produced in malignant and normal tissues. It acts both as an immunosuppressant and as an iron storage protein. As a tumor associated protein, it is related to virally induced tumors, and selective tumor targeting by radiolabeled antiferritin antibodies has led to its use in clinical trials. In patients with advanced Hodgkin's disease who have failed conventional therapy, 131I antiferritin produced partial remissions, while 90Y antiferritin led to complete remissions and a demonstrable dose-response relationship. Combining the variable low-dose radiation patterns produced by radiolabeled antibody therapy with chemotherapy in the treatment of hepatocellular cancer has led to enhanced tumor cytotoxicity and, in some cases, the conversion of non-resectable hepatoma to resectable. Further, the potential for clinical and laboratory investigation of radiolabeled antibody therapy is discussed in light of new findings.
Order
S E
SE
Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, Maryland.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods; D003131:Combined Modality Therapy; D005293:Ferritins / Q000276:immunology*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D015021:Yttrium Radioisotopes; D005293:Ferritins