[Cardiac effects of prostacyclin infusion].
The purpose of this investigation is the evaluation of cardiac effects of short-term prostacyclin intravenous infusion. Prostaglandin I2 has been administered at rate of 5 ng/kg/min. Systolic blood pressure (mmHg) remains unchanged, heart rate (beats/min) significantly increases (p less than 0.01). Diastolic blood pressure (mmHg) significantly decreases (p less than 0.01) during the first hour: this decrease is not significant during the second and third hour. The QTc shortens during the first and third hour and returns to normal values during 60-90 minutes of infusion. This preliminary study suggests that cardiac effects of prostacyclin infusion are indirect.
Camici
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Clinica Medica II, Università degli Studi di Pisa.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004562:Electrocardiography / Q000187:drug effects; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013997:Time Factors
D011464:Epoprostenol
Effetti cardiaci della infusione di prostaciclina.