Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation.
We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p less than 0.01) or at 15 min (p less than 0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p less than 0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.
Miyagawa
H
H
Allergic Disease Center, Creighton University School of Medicine, Omaha, Nebr.
Nabe
M
M
Hopp
R J
RJ
Agrawal
D K
DK
Bewtra
A K
AK
Townley
R G
RG
D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*; D010972:Platelet Activating Factor / Q000008:administration & dosage*
D010972:Platelet Activating Factor