Oral administration of Chlorella vulgaris augments concomitant antitumor immunity.
Chlorella vulgaris, an unicellular green algae, or its acetone-extract (Ac-Ex) were administered orally to Meth A tumor bearing BALB/c or (BALB/c x DBA/2)F1 (CDF1) mice. When CDF1 mice were fed daily with 10% dried powder of Chlorella vulgaris (CVP) containing diet before and after Meth A tumor inoculation, the growth of rechallenged Meth A tumor was significantly suppressed in an antigen-specific manner. Augmentation of antitumor resistance was exhibited also by Winn assay using lymph node cells of tumor-bearing mice orally administered with CVP or Ac-Ex. Antigen-specific concomitant immunity in these mice were mediated by cytostatic T cells but not by cytotoxic T cells. Natural killer cells seemed not to contribute in antitumor resistance in this system.
Tanaka
K
K
Department of Parasitology, University of Tokushima School of Medicine, Japan.
Tomita
Y
Y
Tsuruta
M
M
Konishi
F
F
Okuda
M
M
Himeno
K
K
Nomoto
K
K
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000302:isolation & purification; D000284:Administration, Oral; D000818:Animals; D000951:Antigens, Neoplasm; D002708:Chlorella / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology / Q000628:therapy*; D007108:Immune Tolerance; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm