Proportion cured and mean log survival time as functions of tumour size.
We obtained maximum likelihood estimates (MLEs) of the proportion cured pi c and mean log survival time mu t for a sample of 4355 patients with intraocular melanoma whose survival times subsequent to treatment were assumed to follow a log-normal distribution. Following stratification by tumour size, MLEs of pi c and mu t derived for each stratum correlate inversely with tumour size. We then expressed pi c and mu t as continuous functions of tumour size and calculated MLEs for the parameters of these functions from the entire sample. This investigation documents for ocular melanoma a significant relationship of tumour size to both cured fraction and mean log survival time.
Gamel
J W
JW
Department of Ophthalmology, University of Louisville, KY.
McLean
I W
IW
Rosenberg
S H
SH
D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D008545:Melanoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015233:Models, Statistical; D011336:Probability; D011379:Prognosis; D016019:Survival Analysis; D013997:Time Factors; D014604:Uveal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery