Parkinson's disease and cytochrome P450: a possible link?
The possibility that idiopathic Parkinson's disease may be linked to a deficiency of an important detoxifying enzyme such as the cytochrome P450 enzyme bufuralol hydroxylase is examined. A hypothetical model of how this might operate to produce early onset Parkinson's disease is suggested.
Shahi
G S
GS
Department of Physiology, National University of Singapore.
Das
N P
NP
Moochhala
S M
SM
D001921:Brain / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D020267:MPTP Poisoning; D006899:Mixed Function Oxygenases / Q000172:deficiency; D008954:Models, Biological; D010300:Parkinson Disease / Q000201:enzymology* / Q000209:etiology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C043872:bufuralol 1'-hydroxylase; D004298:Dopamine