[Effect of an angiogenesis-promoting dipeptide on microcirculation in experimental chronic stomach ulcer in the rat].
The influence of an angiogenesis stimulating dipeptide (Lys-Pro-derivative) on the blood flow rate of the stomach was tested in rats suffering from ulcus ventriculi by microspheres technique. 21 days after operation (acetic acid model by Takagi) the ulcers in the group treated with the dipeptide were healed completely, but not in the control group. The higher blood flow in the ulcer area of the dipeptide group radiometrically gained, was not changed significantly (U-test by Man-Whitney). These results demonstrate, that the process of rapid wound healing promoted by the dipeptide cannot entirely be explained by a higher blood flow of the stomach.
Brandt
W
W
Humboldt-Universität Berlin-Bereich Medizin Charité.
Modersohn
D
D
Buntrock
P
P
Johannsen
B
B
Berndt
H
H
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects
D043925:Angiogenesis Inducing Agents; D004151:Dipeptides
Die Wirkung eines die Angiogenese fördernden Dipeptids auf die Mikrozirkulation beim experimentellen chronischen Ulcus ventriculi der Ratte.