Pancytopenia in a patient given pyrimethamine and sulphamethoxidiazine during pregnancy.
This is a report of a pregnant woman who became pancytopenic in the second trimester following pyrimethamine administration. The patient recovered on steroid, antibiotics, transfusion, folic acid and folinic acid therapy, and the pregnancy was uneventful afterwards. The patient was delivered of a healthy term-infant.
Pajor
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2nd Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000139:chemically induced*; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000009:adverse effects*; D013417:Sulfameter / Q000008:administration & dosage / Q000009:adverse effects*; D014123:Toxoplasmosis / Q000188:drug therapy*
D013417:Sulfameter; D011739:Pyrimethamine