Alterations of glomerular filtration rate during cold exposure in progressive systemic sclerosis: measurement with technetium-99m DTPA.
We investigated the changes of the glomerular filtration rate (GFR) that occurred when the right hand was soaked in 7 degrees C water. The subjects were 5 patients with progressive systemic sclerosis who did not have clinical evidence of renal involvement. The clearance rate constant of 99mTc-DTPA, which is excreted by glomerular filtration, was measured with a cadmium telluride detector placed over the chest wall. In response to the cold exposure, the constant rose in 2 patients and remained unchanged in the remaining 3 patients. After termination of cold exposure, the constant fell in all 5 patients, suggesting renal Raynaud's phenomenon. These findings suggest that the renal vasculature in these patients has an abnormal response to cold exposure.
Yamauchi
K
K
Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Arimori
S
S
D000328:Adult; D000368:Aged; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D011928:Raynaud Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D012079:Renal Circulation / Q000502:physiology; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics
D016284:Technetium Tc 99m Pentetate