Sphingomyelin synthesis in Fasciola hepatica.
Whole worms and/or homogenates of F. hepatica incorporate label from cytidine-5-diphospho[methyl-14C]choline,[1-14C]palmitoylCoA,[U- 14C]serine,[2-14C]methionine, [U-14C]glycine, [U-14C]threonine and [U-14C]aspartate into the various intermediates of sphingomyelin synthesis (ketosphinganine, sphinganine, sphingosine, ceramide and sphingomyelin). This suggests that sphingomyelin synthesis in F. hepatica occurs by a pathway similar to that found in mammals. However, there is some evidence that in F. hepatica 3-ketosphinganine may be N-acylated prior to reduction and dehydrogenation.
Bankov
I
I
Central Laboratory of Helminthology, Bulgarian Academy of Sciences, Sofia.
Barrett
J
J
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002518:Ceramides / Q000096:biosynthesis; D005210:Fasciola hepatica / Q000378:metabolism*; D013109:Sphingomyelins / Q000096:biosynthesis*; D013110:Sphingosine / Q000378:metabolism
D000596:Amino Acids; D002518:Ceramides; D013109:Sphingomyelins; D013110:Sphingosine