title: Effect of vitamin E on the oxidative state of glutathione in plasma.
abstract: Reduced and oxidized glutathione levels in red blood cells and plasma from humans were determined after oral vitamin E treatment. The experiments confirmed that vitamin E enhances reduced glutathione levels in red blood cells. Moreover, vitamin E supplement resulted in a significant reduction of the plasma oxidized glutathione content. Thus, it seems that the effect of vitamin E on the reduced glutathione content is not exerted via direct modulation of the glutathione-synthesizing enzymes, but rather by a more general mechanism of preserving reduced glutathione consumption by reducing the burden of the glutathione system.
authors.affiliation: Eye Clinic, 1st School of Medicine, University of Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Costagliola
authors.forename: M
authors.initials: M
authors.lastname: Menzione
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D005978:Glutathione