Evaluation of the mutagenic potential of endosulfan using the Salmonella/mammalian microsome assay.
The mutagenic potential of endosulfan, a polychlorinated insecticide, was assessed using the highly sensitive Salmonella tester strains TA97(a), TA98, TA100 and TA102. It exhibited a toxic effect at dose levels of 50 micrograms/plate and higher. Plate incorporation studies did not show mutagenic response with any of the tester strains used. A modification of the assay using a preincubation procedure showed mutagenic activity with and without metabolic activation with TA97(a) only. Increased toxicity was observed after addition of phenobarbital-induced S9 mix.
Pandey
N
N
Environmental Microbiology Section, Industrial Toxicology Research Centre, Lucknow, India.
Gundevia
F
F
Ray
P K
PK
D000818:Animals; D001711:Biotransformation; D004726:Endosulfan / Q000378:metabolism / Q000633:toxicity*; D008862:Microsomes, Liver; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium
D009153:Mutagens; D004726:Endosulfan