title: Effects of zeranol implants on post-castration response in calves.
abstract: Suckling and yearling calves were surgically castrated and one half of each group implanted with 36 mg zeranol at time of castration. Both treated and control cattle of each class were maintained as a group and evaluated for swelling of the scrotum, inflammation and healing, plasma prostaglandin levels and weight gain. Swelling and inflammation of the scrotum were less in treated suckling calves than in controls at both 7 and 14 d after castration, though this difference was not statistically significant. In yearlings at 7 d after castration, treated cattle had more swelling than controls; however at 14 d, treated cattle had less swelling and inflammation with only one treated yearling having an open scrotal wound versus 6 (P less than .03) in the control group. Plasma prostaglandin levels as indicated by plasma malondialdehyde increased from d 0 to 14; however no significant treatment differences were observed for either age group. Suckling calves treated with zeranol gained 9.79 kg more (P less than .03) than non-treated calves during the 97 d of trial while the yearlings treated with zeranol gained 16.78 kg more (P less than .01) than controls during 102 d. It is concluded from the increased growth and reduced scrotal swelling and inflammation in treated cattle that zeranol implantation could possibly have a beneficial effect in improving the healing process after castration.
authors.affiliation: Pitman-Moore, Inc., Terre Haute, IN 47808.
authors.forename: T W
authors.initials: TW
authors.lastname: Robb
authors.forename: A D
authors.initials: AD
authors.lastname: Wood
mesh_terms: D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development*; D001831:Body Temperature / Q000187:drug effects; D002417:Cattle / Q000254:growth & development*; D004343:Drug Implants; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D009919:Orchiectomy / Q000662:veterinary*; D011453:Prostaglandins / Q000097:blood; D011897:Random Allocation; D012611:Scrotum / Q000187:drug effects / Q000473:pathology; D015430:Weight Gain / Q000187:drug effects*; D015029:Zeranol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004343:Drug Implants; D011453:Prostaglandins; D015029:Zeranol