title: Testicular obstruction: clinicopathological studies.
abstract: Genital tract reconstruction has been attempted in subfertile men with obstructive azoospermia (370 patients) or unilateral testicular obstruction (80 patients), and in vasectomised men undergoing reversal for the first (130 patients) or subsequent (32 patients) time. Histopathological changes in the obstructed testes and epididymes, and immunological responses to the sequestered spermatozoa have been studied to gain insight into possible causes of failure of surgical treatment. The results of surgery have been assessed by follow-up sperm counts and occurrence of pregnancies in the female partners. The best results were obtained with vasectomy reversal (patency 90%, pregnancy 45%), even after failed previous attempts (patency 87%, pregnancy 37%). Epididymovasostomy gave good results with postinfective caudal blocks (patency 52%, pregnancy 38%), while postinfective vasal blocks were better corrected by total anatomical reconstruction (patency 73%, pregnancy 27%) than by transvasovasostomy (patency 9%, no pregnancies). Poor results were obtained with capital blocks (patency 12%, pregnancy 3%), in which substantial lipid accumulation was demonstrated in the ductuli efferentes; three-quarters of these patients had sinusitis, bronchitis or bronchiectasis (Young's syndrome). There is circumstantial evidence to suggest that this syndrome may be a late complication of mercury intoxication in childhood. After successful reconstruction, fertility was relatively reduced in those men who had antibodies to spermatozoa, particularly amongst the postinfective cases. Similarly, impaired fertility was found in men with unilateral testicular obstruction and antibodies to spermatozoa. Mononuclear cell infiltration of seminiferous tubules and rete testis was noted occasionally, supporting a diagnosis of autoimmune orchitis; although rare, this was an important observation as the sperm output became normal with adjuvant prednisolone therapy.
authors.affiliation: St Bartholomew's Hospital, London.
authors.forename: W F
authors.initials: WF
authors.lastname: Hendry
authors.forename: D A
authors.initials: DA
authors.lastname: Levison
authors.forename: M C
authors.initials: MC
authors.lastname: Parkinson
authors.forename: J M
authors.initials: JM
authors.lastname: Parslow
authors.forename: M G
authors.initials: MG
authors.lastname: Royle
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D004822:Epididymis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000209:etiology; D013094:Spermatozoa / Q000276:immunology; D013733:Testicular Diseases / Q000276:immunology / Q000473:pathology / Q000601:surgery; D014649:Vas Deferens / Q000473:pathology / Q000601:surgery*; D014659:Vasectomy
chemical_list: D001323:Autoantibodies