Antibodies to synthetic peptide (125-148) of the alpha-subunit of human nicotinic acetylcholine receptor in sera from patients with myasthenia gravis.
We measured the amount of antibodies to a synthetic peptide that corresponds to the alpha-subunit residues Lys125-Thr148 of human acetylcholine receptor (AChR) in myasthenic sera. We detected anti-peptide antibodies in 52% (89/171) of the patients with myasthenia gravis (MG), but none in any of the healthy controls. Anti-peptide antibodies should provide a valuable immunologic parameter for the clinical evaluation of MG, but no apparent correlation was observed between the titers of anti-peptide and anti-AChR antibodies.
Ohta
M
M
Clinical Research Center, Utano National Hospital, Faculty of Pharmaceutical Science, Kyoto, Japan.
Ohta
K
K
Itoh
N
N
Nishitani
H
H
Hara
H
H
Hayashi
K
K
D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology*; D011978:Receptors, Nicotinic / Q000276:immunology*; D013945:Thymoma / Q000150:complications; D013953:Thymus Neoplasms / Q000150:complications
D001323:Autoantibodies; D010446:Peptide Fragments; D011978:Receptors, Nicotinic; C066297:acetylcholine receptor alpha-subunit (125-148)