title: [Mechanism of action and therapeutic use of cyclosporin A. Experimental and clinical experiences in dermatology].
abstract: The clinical application of cyclosporine A caused many success in transplantation surgery as well as in the treatment of (auto-) immune disorders. The biological highly active substance differs from conventional immunosuppressive drugs (i.e. steroids, azathioprine) by it's selective action on T-lymphocytes. However, current experimental findings indicate a direct influence on epidermal keratinocytes, too. First therapeutical experiences, concerning systemic and topical application in different skin diseases are summarized.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten Bereichs Medizin der Martin-Luther-Universität Halle-Wittenberg.
authors.forename: R
authors.initials: R
authors.lastname: Laub
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D003524:Cyclosporins / Q000627:therapeutic use*; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D003524:Cyclosporins
vernacular_title: Wirkungsweise und therapeutische Anwendung von Cyclosporin A. Experimentelle und klinische Erfahrungen in der Dermatologie.