Aging and cognition: facilitation of recent memory in aged nonhuman primates by nimodipine.
Impairments of recent memory are a common complaint associated with aging and especially with respect to certain neural pathological conditions that may accompany aging. While this is well recognized, there is little clear evidence for a viable therapeutic treatment. Recently, however, certain investigations have suggested that blocking neuronal calcium channels may be an effective treatment for the memory impairments that are associated with brain injury as well as the memory failures that may occur during aging. The present research supports this suggestion by demonstrating that the dihydropyridine calcium channel blocker, nimodipine, will significantly improve the stabilized performance of 28-29-year-old rhesus monkeys when they are tested on a delayed-response task which depends upon trial-specific, or recent, memory.
Sandin
M
M
Behavioral Neurobiology Laboratory, North Carolina State University, Raleigh 27695-7801.
Jasmin
S
S
Levere
T E
TE
D000375:Aging / Q000187:drug effects*; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D005260:Female; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000187:drug effects*; D009553:Nimodipine / Q000494:pharmacology*
D009553:Nimodipine