[The effect of biocarbazine on the indices of humoral and cellular immunity in mice].
Biocarbazin (5-3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide) when administered in different doses and schedules depressed the primary immune response of mice to erythrocytes (SE). A dose-dependent effect on the immunosuppression degree is revealed. Both the inductive and productive stages of antibody formation are sensitive to the immunosuppressive action of the agent. Under certain conditions biocarbazin induced a sharp suppression of humoral immune response. At the same time, it enhanced significantly the delayed-type hypersensitivity (DTH) response to SE.
Ancheva
M N
MN
Boeva
M N
MN
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D003606:Dacarbazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects* / Q000276:immunology; D007114:Immunization; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation; D013997:Time Factors
D003606:Dacarbazine
Vliianie biokarbazina na pokazateli gumoral'nogo i kletochnogo immuniteta mysheĭ.