Haemostatic changes during continuous oestradiol-progestogen treatment of postmenopausal women.
To identify changes in haemostatic balance during continuous oestradiol-progestogen treatment, 60 postmenopausal women with climacteric complaints, mean age 55.4 years (range 44-68) were randomly allocated to receive one of four hormone replacement regimens for one year. All four formulations were administered daily and continuously, each contained 2 mg of 17 beta-oestradiol in combination with either norethisterone acetate, 1 mg (group A) or 0.5 mg (group B) or megestrol acetate, 5 mg (group C) or 2.5 mg (group D). No significant changes occurred during treatment within or between the groups in platelet count, fibrinogen and 2-antiplasmin. Activated partial thromboplastin time was shortened (P less than 0.05) in group D and a decline in factor VII activity and antigen (P less than 0.001) and in ATIII activity (P less than 0.05) was noted in group A. Protein C tended to decline in all treatment groups but statistically significant changes were noted only in groups A and C. Two women developed crural thrombosis during the observation period.
Sporrong
T
T
Department of Obstetrics and Gynecology, University of Göteborg.
Mattsson
L A
LA
Samsioe
G
G
Stigendal
L
L
Hellgren
M
M
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D002979:Climacteric / Q000187:drug effects; D004311:Double-Blind Method; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods*; D005167:Factor VII / Q000032:analysis; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D015849:Plasminogen Inactivators / Q000032:analysis; D011486:Protein C / Q000032:analysis; D013927:Thrombosis / Q000209:etiology; D014841:von Willebrand Factor / Q000032:analysis
D015849:Plasminogen Inactivators; D011486:Protein C; D014841:von Willebrand Factor; D004958:Estradiol; D000990:Antithrombin III; D005167:Factor VII; D010958:Plasminogen