[Population pharmacokinetic analysis of indocyanine green retention rate at 15 minutes].
Using the population pharmacokinetic (Bayesian) method, we investigated the indocyanine green (ICG) retention rate at 15 minutes (R 15) in patients with liver disease. For the Bayesian analysis, the mean and variance of parameters, the disappearance rate (K) and the distribution volume, were calculated by the one compartment analysis with data of inpatients. The mean value of the disappearance rate (K) was shown to be smaller and the variances of parameters of the patients were larger than normal values reported, so that it was suggested that the studied group included patients with various kinds of liver diseases. Accordingly, the Bayesian analysis was performed using above statistical results. The distribution volumes, calculated from three points measurements by Bayesian method, were estimated smaller and the initial concentrations higher than those obtained by the one compartment analysis. However, the retention rate (R 15) were well correlated the results of one compartment analysis. The Bayesian analysis using one point measurement at 15 minutes, resulted that the values of retention rate (R 15) were shown about 17% lower, but well correlated with the coefficient gamma = +0.9972 to those obtained by usual method. The disappearance rate (K), which calculated simultaneously from the one point analysis, showed the lowest value on liver cirrhosis. So that, the application of Bayesian analysis to the one point measurement of ICG test was useful to clinical evaluation of liver disease.
Kinoshita
K
K
Laboratory of Clinical Research, Toyooka Hospital.
Maruo
S
S
D001499:Bayes Theorem; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests
D007208:Indocyanine Green