title: Sonography in the evaluation of treatment of differentiated thyroid cancer. First results in 158 patients.
abstract: Sonographic examination of soft tissues of the neck was used to search for recurrent thyroid cancer in 158 patients. Two hundred and thirty-six sonographic findings were evaluated. Specificity of the method, regardless of the type of recurrence, was 0.96, sensitivity 0.66, precision 0.81, predictive value of negative finding 0.72. This compares favorably with the results of examination by palpation (sensitivity 0.32 to 0.52, according to the type of recurrence), or with those of palpation combined with thyroglobulin estimation (sensitivity 0.50 to 0.60). Most important was the possibility of early detection of unpalpable recurrent lesions showing no radioiodine uptake, or relapses with low thyroglobulin production. Systematic evaluation of out-patients using sonography could lower the need for radioiodine scans that are necessarily connected with thyroid hormone therapy withdrawal and that are usually performed in in-patients.
authors.affiliation: Research Institute of Endocrinology, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Fexa
authors.forename: J
authors.initials: J
authors.lastname: Nĕmec
authors.forename: Z
authors.initials: Z
authors.lastname: Novák
authors.forename: J
authors.initials: J
authors.lastname: Zimák
authors.forename: J
authors.initials: J
authors.lastname: Bednár
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D014463:Ultrasonography
chemical_list: D013954:Thyroglobulin