title: [Long-term therapy of tumor pain using morphine-retard tablets].
abstract: We analysed the effect of sustained-release morphine tablets in 174 patients with severe cancer pain. A good relief of pain could be obtained in 65% of the patients within the first week and in 80% of the patients at the end of therapy. The mean daily dose was at 178 mg morphine, six patients needed more than 1000 mg per day. The sustained-release morphine was given at fixed intervals, in 80% of the cases every eight hours. No severe side-effects were associated with long-term morphine therapy. We often saw nausea and vomiting, constipation and drowsiness, but these side-effects decreased after the first weeks of treatment. Only in ten patients we had to stop therapy because of side-effects. Morphine can be used successfully in the treatment of cancer pain for long periods without concern about tolerance.
authors.affiliation: Abteilung IV-KH Oststadt, Zentrum für Anästhesiologie, Medizinischen Hochschule Hannover.
authors.forename: J
authors.initials: J
authors.lastname: Sorge
authors.forename: C
authors.initials: C
authors.lastname: Lehmkuhl
authors.forename: K
authors.initials: K
authors.lastname: Lohse
authors.forename: H
authors.initials: H
authors.lastname: Herrmann
authors.forename: I
authors.initials: I
authors.lastname: Pichlmayr
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003692:Delayed-Action Preparations; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009369:Neoplasms / Q000503:physiopathology; D010146:Pain / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D009020:Morphine
vernacular_title: Langzeittherapie von Tumorschmerzen mit Morphin-retard-Tabletten.