title: Bone mineral content of Gambian and British children aged 0-36 months.
abstract: The influence of age, sex and body size on the bone mineral content of the radius (BMC) measured by single-photon absorptiometry has been studied in 134 British and 243 rural Gambian children aged 0-36 months. Growth rates and childhood nutrition, including calcium intakes, were markedly different in the two communities. In both groups BMC increased with age and was higher in boys (8%, P less than 0.001). Adjustment for body size (height, weight, bone width), using multiple regression analysis, removed the age effect and reduced the sex difference to 4% (P less than 0.01). Gambian children had significantly lower BMCs than British children of the same age (P less than 0.001), averaging 11% close to birth and diverging to a calculated difference of 31% at 36 months. The differential was reduced after adjustment for body size but remained significant (P less than 0.01) with BMC values diverging from birth to a predicted difference of 12% at 15 kg body weight. The extent to which these results reflect the low calcium intakes of Gambian children requires further study.
authors.affiliation: Medical Research Council Dunn Nutrition Unit, Cambridge, England.
authors.forename: A
authors.initials: A
authors.lastname: Prentice
authors.forename: M A
authors.initials: MA
authors.lastname: Laskey
authors.forename: J
authors.initials: J
authors.lastname: Shaw
authors.forename: T J
authors.initials: TJ
authors.lastname: Cole
authors.forename: D R
authors.initials: DR
authors.lastname: Fraser
mesh_terms: D000375:Aging / Q000502:physiology; D001827:Body Height; D001835:Body Weight; D015519:Bone Density; D001842:Bone and Bones / Q000033:anatomy & histology; D002675:Child, Preschool; D005260:Female; D005714:Gambia; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011884:Radius; D012727:Sex Characteristics; D006113:United Kingdom