Penetration of [3H]T-2 mycotoxin through abraded and intact skin and methods to decontaminate [3H]T-2 mycotoxin from abrasions.
Penetration of 50 muCi of [3H]T-2 mycotoxin through abraded and intact skin was studied in anesthetized rats sacrificed at 5, 15, 30, 45, 60 and 90 min post-exposure. The greatest penetration was through abraded skin (49 +/- 7%) at 90 min post-exposure, whereas penetration through intact skin (2 +/- 3%) was substantially less (P less than 0.0015). Methods to decontaminate [3H]T-2 mycotoxin from abraded skin over time were studied. Treatment of [3H]T-2 contaminated abrasions by applying Trau + Medic dressing, applying Charcoal Cloth-Anti-bacterial Field Dressing (Charcoal Dressing), or swabbing with povidone-iodine 30 min post-exposure removed 17-32% of the applied [3H]T-2. Immediate blotting with immediate removal of the dressings absorbed 103 +/- 4% (Trau + Medic) and 87 +/- 4% (Charcoal Dressing) of the applied [3H]T-2, while immediate blotting and leaving the dressing in place for 30 min removed 91 +/- 5% (Trau + Medic) and 76 +/- 3% (Charcoal Dressing). It appears that immediate blotting with either dressing followed by immediate removal before application of a clean dressing is an effective method for decontaminating [3H]T-2 from abrasions.
Solberg
V B
VB
U.S. Army Biomedical Research and Development Laboratory, Fort Detrick, Frederick, MD 21702-5010.
Broski
F H
FH
Dinterman
R E
RE
George
D T
DT
D000327:Adsorption; D000818:Animals; D001458:Bandages; D003666:Decontamination; D008297:Male; D011206:Povidone-Iodine / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000293:injuries*; D012869:Skin Absorption; D013605:T-2 Toxin / Q000493:pharmacokinetics*
D011206:Povidone-Iodine; D013605:T-2 Toxin