[Study on the usefulness of haptoglobin used on endoscopic injection sclerotherapy].
The effect of haptoglobin (Hp) used on endoscopic injection sclerotherapy (EIS) was evaluated by examining the increase of serum free hemoglobin (FHb) and the changes of renal function. In control group, the increase of serum FHb (delta FHb) was paralleled with the volume of 5% ethanolamine Oleate (EO) injected intravariceally, and free Hp (FHp) was disappered in this group soon after EIS. On the contrary, in the group treated with Hp, neither the increase of FHb nor decrease of FHp were recognized. The significant increase of urine beta 2 microglobulin and NAG was recognized in control group. Therefore, if Hp is used at initial EIS, it would be prevented that serum FHb due to intravascular hemolysis increases, consequently the possibility of renal dysfunction.
Matsumoto
A
A
Second Department of Internal Medicine, Osaka Medical College.
Miyoshi
H
H
Takada
K
K
Hayashi
K
K
Asada
S
S
Hirata
I
I
Ohshiba
S
S
D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D005260:Female; D006242:Haptoglobins / Q000008:administration & dosage / Q000627:therapeutic use*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000009:adverse effects*; D012597:Sclerosing Solutions / Q000009:adverse effects*; D015911:Sclerotherapy
D006242:Haptoglobins; D006454:Hemoglobins; D009829:Oleic Acids; D012597:Sclerosing Solutions; C033343:ethanolamine oleate