[Preparation of theophylline-sodium salicylate suppositories and determination of factors influencing the in vitro dissolution of the active agents].
Suppositories of theophylline-sodium salicylate were prepared with 10 different vehicles and also with tensids and softeners. With the dynamic diffusion method the drug dissolution and the in vitro diffusion were measured. It was established that proper choice of the vehicle is very important. The highest relative in vitro availability was measured in the case of glyceride base with low hydroxyl value. The diffusion of the active agent can be described by an exponential function.
Regdon
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Pharmazeutisch-Technologisches Institut der Medizinischen Universität Albert Szent-Györgyi, Szeged, Ungarn.
Takarò
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Regdon
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D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005079:Excipients; D012459:Salicylates / Q000008:administration & dosage* / Q000032:analysis; D020156:Salicylic Acid; D012995:Solubility; D013488:Suppositories; D013806:Theophylline / Q000008:administration & dosage* / Q000032:analysis
D005079:Excipients; D012459:Salicylates; D013488:Suppositories; D013806:Theophylline; D020156:Salicylic Acid
Herstellung von Theophyllin-Natriumsalicylat-haltigen Suppositorien und Untersuchung der Einflussfaktoren auf die in vitro Wirkstoffabgabe.