[Flumazenil and volatile anesthetics. Study of possible interferences in rats].
Many works suggest contradictory experimental or clinical results of flumazenil effects during inhalation anaesthesia. In ten rats anaesthesia was induced with 5% isoflurane or halothane during one minute and maintained during 5 minutes with 1% the same halogene anaesthetic in 50% N2O and O2. Then 0.2 mg of flumazenil or a same volume of placebo were administered intraperitoneally and during the last 5 minutes, the rats were exposed in 1% volatile anesthetic gas flow. Sleep times were measured in terms of reestablishment of the righting reflex. Each rat was anesthetized four time: halothane and isoflurane, with flumazenil or placebo. In those conditions, there were no significant changes in sleep times either the anaesthesia were associated, with flumazenil or with placebo.
Costes
Y
Y
Département d'anesthésie-réanimation, Centre hospitalier et universitaire de Besançon.
Bachour
K
K
Flicoteaux
H
H
Neidhardt
A
A
D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000379:methods*; D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous; D002940:Circadian Rhythm; D005442:Flumazenil / Q000494:pharmacology*; D006221:Halothane; D007530:Isoflurane; D051381:Rats; D011919:Rats, Inbred Strains
D005442:Flumazenil; D007530:Isoflurane; D006221:Halothane
Le flumazénil et les anesthésiques volatils. Etude des interférences éventuelles chez le rat.