[Prolongation of transplantation survival time by a PUVA treatment. Experimental and clinical results].
The treatment of transplants by a combination of 8-methoxypsoralen and longwave ultraviolet radiation (PUVA) leads to prolongation of the transplants in allogeneic receivers without immunosuppression. The rejection of skin grafts in the mice could be delayed significantly. The rejection of kidney and heart allografts could be prevented completely. A significant diminution of the acute rejection crises and a raising of the one-year survival rate showed a first clinical study by means of PUVA treatment in human kidney grafts.
Gruner
S
S
Instiut für Medizinische Immunologie, Bereichs Medizin (Charité), Humboldt-Universität, Berlin, DDR.
Oesterwitz
H
H
Kaden
J
J
Meffert
H
H
D000818:Animals; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D011701:PUVA Therapy; D016038:Skin Transplantation; D014184:Transplantation, Homologous
Verlängerung der Transplantatüberlebenszeit durch eine PUVA-Behandlung. Experimentelle und klinische Resultate.