Antimalarial activity of Tanzanian medicinal plants.
Tanzanian medicinal plants were extracted and tested for in vitro antimalarial activity, using the multidrug resistant K1 strain of Plasmodium falciparum. Of 49 plants investigated, extracts of three plants were found to have an IC50 between 5-10 micrograms/ml, extracts of 18 other plants showed an IC50 between 10 and 50 micrograms/ml, all others were less active. The three most active extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Hoslundia opposita Vahl. (Labiatae), and the rootbark of Lantana camara L. (Verbenaceae).
Weenen
H
H
Department of Chemistry, Unversity of Dar es Salaam, Tanzania.
Nkunya
M H
MH
Bray
D H
DH
Mwasumbi
L B
LB
Kinabo
L S
LS
Kilimali
V A
VA
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000032:analysis*; D010963:Plasmodium falciparum / Q000187:drug effects; D013636:Tanzania
D000962:Antimalarials