Unusual reaction to chlorambucil: a case report.
In this brief report we describe a case of cutaneous reaction during treatment of chronic lymphatic leukemia (CLL) with chlorambucil. The patient developed a confluent maculopapular erythema and large flaccid bullae of trunk, legs, feet and mucous membranes, with fever up to 38 degrees C. Toxic epidermal necrolisis (TEN) was supposed and the diagnosis was confirmed by a skin patch test followed by cutaneous biopsy. TEN by chlorambucil is a rare syndrome that may be considered in presence of cutaneous reaction to this drug.
Pietrantonio
F
F
Istituto di Clinica Medica, Universita Cattolica del Sacro Cuore, Roma, Italia.
Moriconi
L
L
Torino
F
F
Romano
A
A
Gargovich
A
A
D002699:Chlorambucil / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D002699:Chlorambucil