title: Thiobarbituric acid-reactive material content and enzymatic protection against peroxidative damage during the course of cryogenic rabbit brain edema.
abstract: The relationship between free radicals reactions and the cell detoxifying system was investigated during the development of brain edema following a cryogenic lesion in the rabbit cerebral cortex. The amount of TBA-reactive material present six hours after freezing was less than in the controls, then increased at 48 and 96 hours. The activity of superoxide dismutase (SOD) decreased 6 hours post-injury; at the same time, we observed a stimulation of catalase activity. The glutathione peroxidase activity (GSH-Px) rose 96 hours post-lesion. The decrease of TBA-reactive products could result from an elimination rate that exceeds generation.
authors.affiliation: Laboratoire de Neurochirurgie Expérimentale et Neurobiologie C.N.R.S. 040603, Université de Bordeaux II, France.
authors.forename: N
authors.initials: N
authors.lastname: Avéret
authors.forename: M
authors.initials: M
authors.lastname: Coussemacq
authors.forename: F
authors.initials: F
authors.lastname: Cohadon
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D003080:Cold Temperature; D004798:Enzymes / Q000502:physiology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D009994:Osmolar Concentration; D010545:Peroxides / Q000378:metabolism*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism; D013858:Thiobarbiturates / Q000494:pharmacology*
chemical_list: D004798:Enzymes; D010545:Peroxides; D013858:Thiobarbiturates; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid