title: Meropenem pharmacokinetics and penetration into an inflammatory exudate.
abstract: The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem in plasma was 1.1 h, with the concentration in plasma declining from a mean of 23.6 micrograms/ml at 1 h to 0.7 micrograms/ml at 6 h. The inflammatory fluid penetration was rapid (time to maximum concentration of drug in serum, 0.75 h), and the penetration was 111%. The recovery of meropenem in urine at 24 h was 65.4% of the administered dose.
authors.affiliation: Department of Medical Microbiology, Dudley Road Hospital, Birmingham, England.
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: M
authors.initials: M
authors.lastname: Logan
authors.forename: M
authors.initials: M
authors.lastname: Cooper
authors.forename: J P
authors.initials: JP
authors.lastname: Ashby
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
mesh_terms: D000328:Adult; D005122:Exudates and Transudates / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D000077731:Meropenem; D013845:Thienamycins / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D013845:Thienamycins; D000077731:Meropenem