title: [Two cases of budgerigar breeder's lung].
abstract: We report 2 patients with Bird breeder's lung associated with keeping budgerigars. Patient 1 kept a budgerigar indoors for 13 years. Histological examination revealed fibrosis and granulomatous changes in the alveolar septa. Among T lymphocyte subsets in BALF, helper T cell were increased. In the serum, precipitating antibodies to budgerigar dropping extract were observed. Patient 2 had kept Budgerigar for 7 months. Histologically, alveolitis was the primary finding, and suppressor T cell in the BALF were increased. Precipitating antibodies to budgerigar dropping extract was observed only in the BALF but not in serum. In patient 1 who showed a chronic course and granuloma formation, helper T cell in the BALF were increased while in patient 2 who showed an acute course and alveolitis, suppressor T cell in the BALF were increased, and precipitating antibody was observed only in the BALF. These findings suggest that T lymphocyte subsets in the BALF differ depending on the stage of hypersensitivity pneumonitis, and specific local antibody production precedes systemic antibody production.
authors.affiliation: First Department of Internal Medicine, Nihon University, School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Majima
authors.forename: F
authors.initials: F
authors.lastname: Kohara
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: N
authors.initials: N
authors.lastname: Ooshima
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: H
authors.initials: H
authors.lastname: Aihara
authors.forename: Y
authors.initials: Y
authors.lastname: Hosokawa
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Horie
mesh_terms: D000917:Antibody Formation; D001716:Bird Fancier's Lung / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology