title: Inhibitory effect of bestatin on the growth of human leukemic cells.
abstract: We examined the effect of bestatin (Ubenimex) on the growth of human leukemic cells (i.e, HL-60, K562, MT-1, MT-2, Molt-4, and Raji cells). The growth of each cell line was inhibited by the cocultivation with bestatin at higher concentrations than employed for clinical use in Japan. [3H]TdR incorporation was also inhibited in MT-1 and MT-2 cells by treatment with bestatin. Degenerated cell-to-cell adhesion was observed among the treated cells. These findings suggest that the inhibitory effect on some leukemic cells, especially on MT-1 cells, results from the inhibition of DNA synthesis.
authors.affiliation: Third Department of Internal Medicine, Hokkaido University, School of Medicine, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakurada
authors.forename: M
authors.initials: M
authors.lastname: Imamura
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Tachibana
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Okabe
authors.forename: M
authors.initials: M
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Sugiura
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007938:Leukemia / Q000473:pathology*; D008855:Microscopy, Electron, Scanning; D013601:T-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex