title: [Clinical study on bronchial asthma patients whose bronchial hypersensitivity has been improved].
abstract: In order to determine which factors would affect the improvement of bronchial hypersensitivity in asthmatic patients, a clinical investigation was performed on 42 cases whose bronchial hypersensitivity had been tested more than two times. The following results were obtained. 1) The numbers of bronchial hypersensitivity-improved cases was 16 while there were 26 unimproved cases. There was no statistical difference in age, sex, type of asthma, severity of disease at first visit or type of therapy between the two groups. FEV1.0% in the bronchial hypersensitivity-improved group was significantly higher than that in the unimproved group (p less than 0.01). 2) In the improved group, all cases (16/16) were shown to have become free of symptoms, but this applied to only 38% (10/26) in the unimproved group. 3) In the 26 cases who had become free of symptoms, the improvement index in histamine test and the ratio of improved cases showed a tendency to increase as the period during which the patient showed no symptoms extended. It was suggested that bronchial hypersensitivity in cases with higher FEV1.0% would improve more easily, and that the induction and maintenance of a symptom free state is important for the improvement of bronchial hypersensitivity.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University.
authors.forename: A
authors.initials: A
authors.lastname: Kawasaki
authors.forename: K
authors.initials: K
authors.lastname: Hoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D001980:Bronchi / Q000276:immunology*; D004804:Eosinophils; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D007073:Immunoglobulin E