title: Hemodialysis does not always protect against recurrence of Wegener's granulomatosis.
abstract: Hemodialysis may protect against disease activity in Wegener's granulomatosis. We report here a 41-year-old woman with Wegener's granulomatosis, in whom renal transplantation was performed after a 10-month period of hemodialysis during which no signs of disease activity were detected. Recurrence of disease did, however, take place 2 years after renal allograft transplantation despite immunosuppressive therapy with cyclosporine A and prednisone. Reinstitution of hemodialysis and graftectomy did not improve the patient's condition but plasmapheresis and treatment with cyclophosphamide and prednisone eliminated all signs of disease within a fortnight. A proposal for better maintenance of these patients is made.
authors.affiliation: First University Clinic of Internal Medicine, Aarhus Municipal Hospital, Denmark.
authors.forename: R S
authors.initials: RS
authors.lastname: Pedersen
authors.forename: N A
authors.initials: NA
authors.lastname: Aunsholt
mesh_terms: D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D014890:Granulomatosis with Polyangiitis / Q000628:therapy*; D006801:Humans; D007674:Kidney Diseases / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000628:therapy; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D006435:Renal Dialysis
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone