Halophilic proteins and the influence of solvent on protein stabilization.
Competition between protein-solvent and protein-protein interactions is arguably the most important contributing factor to polypeptide folding in general. A study of halophilic proteins, correlating their stability and solution structures in different conditions, focuses on the effects of a high salt solvent. A mechanism is proposed to explain how these proteins have adapted to such an extreme environment.
Zaccai
G
G
Institut Laue Langevin, (CNRS URA 1333), Grenoble, France.
Eisenberg
H
H
D001426:Bacterial Proteins / Q000378:metabolism*; D006217:Halobacterium / Q000378:metabolism*; D011487:Protein Conformation; D012492:Salts / Q000378:metabolism; D012997:Solvents / Q000378:metabolism*
D001426:Bacterial Proteins; D012492:Salts; D012997:Solvents