title: Followup of adolescents initially treated for prepubertal-onset major depressive disorder with imipramine.
abstract: This preliminary followup of adolescents (n = 16) with prepubertal-onset major depressive disorder (MDD) suggests that a significant number continue to be depressed or possibly depressed (62%) and have moderate to severe ongoing psychosocial adjustment problems. A concomitant diagnosis of conduct or oppositional disorder at index assessment was a risk factor for an increased incidence of interim depressive episodes and more severe psychosocial adjustment problems including alcohol and drug abuse.
authors.affiliation: Psychiatric Research Institute, St. Francis Regional Medical Center, Wichita, KS.
authors.forename: C W
authors.initials: CW
authors.lastname: Hughes
authors.forename: S H
authors.initials: SH
authors.lastname: Preskorn
authors.forename: M
authors.initials: M
authors.lastname: Wrona
authors.forename: R
authors.initials: R
authors.lastname: Hassanein
authors.forename: S
authors.initials: S
authors.lastname: Tucker
mesh_terms: D000293:Adolescent; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male
chemical_list: D007099:Imipramine