title: Clinical presentation of suspected malignant hyperthermia during anaesthesia in 402 probands.
abstract: As anaesthetists have become more aware of malignant hyperthermia the mortality rate has fallen, but concommitantly the number of dubious and aborted cases has increased. All probands who developed a suspected malignant hyperthermia reaction during anaesthesia and subsequently underwent muscle biopsy were classified according to the clinical presentation. A probability for malignant hyperthermia can be calculated, using the classification, for each type of clinical presentation; this varied from 0.96 to 0.07. Certain clinical features were found to be of more value as predictors than others; these included a high creative kinase and myoglobinuria. The accuracy of prediction depends on a clear contemporaneous description of the clinical events.
authors.affiliation: University Department of Anaesthesia, St. James's University Hospital, Leeds.
authors.forename: F R
authors.initials: FR
authors.lastname: Ellis
authors.forename: P J
authors.initials: PJ
authors.lastname: Halsall
authors.forename: A S
authors.initials: AS
authors.lastname: Christian
mesh_terms: D000293:Adolescent; D003402:Creatine Kinase / Q000378:metabolism; D004198:Disease Susceptibility; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D008406:Masseter Muscle / Q000503:physiopathology; D009132:Muscles / Q000473:pathology*; D009212:Myoglobinuria / Q000209:etiology; D011336:Probability; D012206:Rhabdomyolysis / Q000378:metabolism; D013035:Spasm / Q000503:physiopathology
chemical_list: D003402:Creatine Kinase