Growth hormone response to growth hormone releasing hormone in depression and schizophrenia.
Growth hormone releasing hormone, a 44-amino acid peptide (GHRH-44), was administered (1 micrograms/kg i.v.) to 6 normal controls, 10 schizophrenic subjects, and 7 depressed subjects. A significantly lower growth hormone (GH) response was found in the schizophrenic and depressed groups. Two molecular forms of GH, 22K GH and 20K GH, were also measured but did not further differentiate the three groups of subjects.
Peabody
C A
CA
Department of Psychiatry, University of Texas, Houston.
Warner
M D
MD
Markoff
E
E
Hoffman
A R
AR
Wilson
D M
DM
Csernansky
J G
JG
D000328:Adult; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis; D012565:Schizophrenic Psychology
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone