Behavioral effects of chronic imipramine treatment in genetically nervous pointer dogs.
The genetically nervous pointer dog has been proposed as a model for human anxiety disorders. In a double-blind placebo-controlled study, seventeen nervous pointer dogs were treated for four weeks with imipramine hydrochloride (10 mg/kg), a potent antipanic agent in humans. Although three of the dogs demonstrated marked improvement to imipramine but not placebo treatment after short-term administration, chronic imipramine failed to modify the aberrant behavior in any of the dogs. These findings are discussed in the context of the nervous pointer dog as a model for human anxiety disorders.
Tancer
M E
ME
Section of Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892.
Stein
M B
MB
Bessette
B B
BB
Uhde
T W
TW
D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000235:genetics; D004285:Dogs / Q000235:genetics*; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D012931:Social Environment; D013045:Species Specificity
D007099:Imipramine