Sensitivity of EEG in young rats to toluene exposure.
Effects of toluene on the electroencephalogram (EEG) and its power spectra were measured during a 2-hr exposure in a dynamic inhalational chamber in young rats (30-53 days old) and compared to those in adult rats (63-77 days old). Rats were exposed to one of the three concentrations [low (108-111 ppm), medium (160-163 ppm), and high (407-432 ppm)] of toluene on different days. In tests on sleep-wake cycle, in the young animals the duration of the wake stage (W) was increased with decreases of rapid eye movement (REM) and non-REM (NREM) sleep during hr 1 and hr 2 of exposure to the low concentration. These effects were marked at the medium and the high concentrations. In adult rats, at the low concentration the increase of W and the decrease of REM were observed only at hr 1; however, at medium and high concentrations these changes of W and REM sleep were marked along with a decrease of NREM. Comparison of the changes of duration of different states in rats of two age groups showed that there was a significant difference in the increase of W and the decrease of NREM sleep in young rats at hr 2 of exposure to low concentrations only compared to those in adult rats. Tested on power spectrum in young rats during REM sleep recorded from the visual cortex, the power of delta waves increased at the medium and high concentrations and that of theta wave decreased at the high concentration during hr 2 of exposure compared to the controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Ghosh
T K
TK
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059.
Copeland
R L
RL
Pradhan
S N
SN
D000375:Aging / Q000502:physiology*; D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012890:Sleep / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects; D014050:Toluene / Q000633:toxicity*; D014851:Wakefulness / Q000187:drug effects
D014050:Toluene