title: Binovular human ovarian follicles associated with in vitro fertilization: incidence and outcome.
abstract: Binovular follicles were found in 15 (0.3%) of 4,695 follicles containing oocytes. These binovular follicles were either with adjacent cumulus complexes (9 cases), or separate corona radiata and common cumulus mass (1 case), or two oocytes within a single zona pellucida (5 cases). In each of the latter form, there was a smaller and a larger oocyte. All the smaller oocytes and two larger ones possessed a germinal vesicle, whereas the remaining three larger oocytes were mature and developed normally. Though being exposed to the same intrafollicular milieu, there can be a difference in the maturity of the nucleus and characteristics of the cytoplasm of both oocytes.
authors.affiliation: Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Affiliated with the Sackler School of Medicine, Tel-Aviv University, Zerifin, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Ron-El
authors.forename: H
authors.initials: H
authors.lastname: Nachum
authors.forename: A
authors.initials: A
authors.lastname: Golan
authors.forename: A
authors.initials: A
authors.lastname: Herman
authors.forename: S
authors.initials: S
authors.lastname: Yigal
authors.forename: E
authors.initials: E
authors.lastname: Caspi
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000002:abnormalities* / Q000166:cytology; D010053:Ovary / Q000002:abnormalities / Q000166:cytology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology