title: Endothelin-like immunoreactivity in human breast cyst fluid.
abstract: Immunoreactive endothelin has been detected in 21 of 43 samples of breast cyst fluid (21 cases; 3.5 +/- 0.6 pmol/l, mean +/- SEM. Other 22 cases; not detectable, less than 0.5 pmol/l). Fast protein liquid chromatographic analysis of the immunoreactive endothelin of pooled breast cyst fluid showed two immunoreactive peaks; one in the void volume and the other in the position of endothelin-1. It is probable that endothelin-1 is produced by the epithelial cells lining breast cysts, but significance of the presence of endothelin-1 in breast cyst fluid remains to be elucidated.
authors.affiliation: Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: L C
authors.initials: LC
authors.lastname: Lai
authors.forename: M A
authors.initials: MA
authors.lastname: Ghatei
authors.forename: V H
authors.initials: VH
authors.lastname: James
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D002851:Chromatography, High Pressure Liquid; D016232:Endothelins / Q000032:analysis*; D005122:Exudates and Transudates / Q000737:chemistry*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry*; D006801:Humans; D011863:Radioimmunoassay
chemical_list: D016232:Endothelins