title: Choroid plexus cysts and chromosomal defects.
abstract: During a 4-year period, 83 pregnant women with fetal choroid plexus cysts were investigated in our unit. Abnormal karyotypes were found in 20 fetuses, including trisomy 18 (n = 16), trisomy 13 (n = 1), triploidy (n = 1) and translocation Down's syndrome (n = 2). All fetuses with chromosomal defects had structural malformations in addition to the choroid plexus cysts.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital of Medicine and Dentistry, Denmark Hill, London.
authors.forename: J G
authors.initials: JG
authors.lastname: Thorpe-Beeston
authors.forename: C M
authors.initials: CM
authors.lastname: Gosden
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D002831:Choroid Plexus; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D003560:Cysts / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D014314:Trisomy; D014463:Ultrasonography