title: Effect of saline cathartics on the adsorption of sulphamethoxazole to activated charcoal.
abstract: The effect of added saline cathartics (sodium sulfate and magnesium sulfate) on the in vitro adsorption of sulphamethoxazole to activated charcoal was determined. Sulphamethoxazole, at 0.00125, 0.0025 and 0.005 mg/ml, had a 56.77 to 91.70 per cent adsorption to 50 mg and 200 mg activated charcoal. As the concentration of the activated charcoal was increased from 50 mg to 1000 mg, there was an increase in the amount of sulphamethoxazole adsorbed at 0.125, 0.25 and 0.5 mg/ml. The amount of sulphamethoxazole (0.125-0.5 mg/ml) adsorbed ranged from 10.33 to 83.67 per cent with a B50 value of 472.33 mg. At 7.5 mg/ml, the common saline cathartics sodium sulfate and magnesium sulfate decrease the B50 values to 274.65 and 41.20 mg, respectively. Both saline cathartics enhanced adsorption of sulphamethoxazole to activated charcoal.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
authors.forename: A
authors.initials: A
authors.lastname: Akintonwa
authors.forename: O E
authors.initials: OE
authors.lastname: Orisakwe
mesh_terms: D000327:Adsorption; D002400:Cathartics; D002606:Charcoal / Q000032:analysis*; D008278:Magnesium Sulfate; D010316:Particle Size; D013420:Sulfamethoxazole / Q000032:analysis*; D013431:Sulfates
chemical_list: D002400:Cathartics; D013431:Sulfates; C012036:sodium sulfate; D002606:Charcoal; D008278:Magnesium Sulfate; D013420:Sulfamethoxazole