title: Expression of cellular effector functions and production of reactive nitrogen intermediates: a comparative study including T lymphocytes, T-like cells, neutrophil granulocytes, and mononuclear phagocytes.
abstract: The ability of various cell types to secrete reactive nitrogen intermediates (RNI) upon functional activation was comparatively assessed. Neither in T lymphocyte clones mediating MHC class I or class II antigen-restricted killing via alpha/beta T cell receptor (TcR) or MHC-unrestricted killing via gamma/delta TcR, nor in peripheral blood mononuclear cells expressing natural killer or lymphokine-activated killer activity, target cell lysis was associated with detectable RNI production. Also, activated neutrophil granulocytes did not secrete RNI. In contrast, bone marrow-derived mononuclear phagocytes, activated to express tumoricidal activity, secreted marked RNI activity.
authors.affiliation: Institute for Immunology and Virology, University of Zurich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Keller
authors.forename: R
authors.initials: R
authors.lastname: Keist
authors.forename: P
authors.initials: P
authors.lastname: Erb
authors.forename: T
authors.initials: T
authors.lastname: Aebischer
authors.forename: G
authors.initials: G
authors.lastname: De Libero
authors.forename: M
authors.initials: M
authors.lastname: Balzer
authors.forename: P
authors.initials: P
authors.lastname: Groscurth
authors.forename: H U
authors.initials: HU
authors.lastname: Keller
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism; D002999:Clone Cells; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D051381:Rats; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*
chemical_list: D009573:Nitrites; D009569:Nitric Oxide; D001120:Arginine; D009584:Nitrogen