title: [Continuous veno-venous hemofiltration in acute renal insufficiency].
abstract: A fully pump-assisted continuous veno-venous hemodiafiltration system (CVVHDF) was studied in 10 acute renal failure patients. A counter current pump system ensured slow dialysis at a mean flow rate of 24.6 +/- 0.6 ml/min (single pass) and guaranteed recovery of 97% of dialysate. Ultrafiltration rates were controlled by a separate occlusive pump, connected to the dialysate compartment. Blood was circulated by mean of a third pump at flow rates ranging form 100 to 150 ml/min. Mean duration of CVVHDF was 197 +/- 32 h (range 96-336). Mean serum creatinine and urea before initiation of CVVHDF were 525 +/- 52 mumol/l and 36 +/- 14 mmol/l and stabilized after 4-7 days of CVVHDF at 280 +/- 27 mumol/l and 14 +/- 3 mmol/l. Hemodynamic parameters remained stable. Glucose and phosphate removal by CVVHDF was 296 +/- 42 mmol/day and 33 +/- 6 mmol/day respectively. Fractional losses of aminoacids given by parenteral nutriton averaged 8 +/- 1%. An 69 filters induced no significant changes in leucocyte and thrombocyte counts and only a slight decrease in pO2 (-0.78 +/- 0.30 K Pa at 60 min). We conclude that CVVHDF is a safe, efficient and reliable treatment modality, allowing a good control of the fluid balance.
authors.affiliation: Division de Néphrologie, Hôpital Cantonal Universitaire de Genéve.
authors.forename: H
authors.initials: H
authors.lastname: Freudiger
authors.forename: M
authors.initials: M
authors.lastname: Lévy
authors.forename: P
authors.initials: P
authors.lastname: Suter
authors.forename: H
authors.initials: H
authors.lastname: Favre
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D014882:Water-Electrolyte Balance
chemical_list: D000596:Amino Acids; D005947:Glucose
vernacular_title: Hémodiafiltration continue veino-veineuse dans l'insuffisance rénale aiguë.