title: Histopathological changes in simian immunodeficiency virus infection.
abstract: The histological lesions were studied in seven rhesus and three cynomolgus monkeys infected with simian immunodeficiency virus for periods ranging from nine weeks to 18 months. Lymphoreticular changes included hyperplasia, follicular involution and depletion, and one animal had amyloidosis of the spleen. Hyperplastic changes also took place in mucosa-associated lymphoid tissue and infiltrations occurred in the vaginal mucosa of one animal, which could be significant in sexual transmission of the infection. The range of opportunistic infections was small compared with that in human AIDS patients, although two monkeys had Pneumocystis carinii pneumonia. Enterocolitis was a common finding and brown adipose tissue was transformed into a large vacuolated type. Lesions of the central nervous system were found in five of nine monkeys, and consisted of foci of glial activity and perivascular and meningeal lymphocytic infiltration. A lymphoma involving the lumbar spinal cord developed in one animal.
authors.affiliation: Public Health Laboratory Service, Centre for Applied Microbiology and Research, Division of Pathology, Salisbury, Wiltshire, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Baskerville
authors.forename: A
authors.initials: A
authors.lastname: Ramsay
authors.forename: M P
authors.initials: MP
authors.lastname: Cranage
authors.forename: N
authors.initials: N
authors.lastname: Cook
authors.forename: R W
authors.initials: RW
authors.lastname: Cook
authors.forename: M J
authors.initials: MJ
authors.lastname: Dennis
authors.forename: P J
authors.initials: PJ
authors.lastname: Greenaway
authors.forename: P A
authors.initials: PA
authors.lastname: Kitchin
authors.forename: E J
authors.initials: EJ
authors.lastname: Stott
mesh_terms: D002001:Adipose Tissue, Brown / Q000473:pathology; D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D007668:Kidney / Q000473:pathology; D008208:Lymphatic System / Q000473:pathology; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009894:Opportunistic Infections / Q000150:complications; D011020:Pneumonia, Pneumocystis / Q000150:complications; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D015302:Simian Immunodeficiency Virus