Short-term tests and long-term prospects for colon cancer prevention.
Five assay systems that have been used for identifying possible carcinogenic factors responsible for human colon cancer are described. These are: Salmonella, colonic micronuclei, colonic epithelial proliferation and aberrant crypt assays, and polyp recurrence trials. The assays have led to the development and testing of 7 hypotheses. A review of this process points to the importance of specificity in the assay system.
Bruce
W R
WR
Ontario Cancer Institute, Toronto, Canada.
D000818:Animals; D001681:Biological Assay; D002136:Calcium, Dietary / Q000009:adverse effects; D003106:Colon / Q000382:microbiology / Q000469:parasitology / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000209:etiology / Q000517:prevention & control*; D006801:Humans
D002136:Calcium, Dietary