[The antitumor effect of an extract of human umbilical cord].
The study was concerned with the evaluation of effect of the extract of a human fetal organ, the umbilical cord, on development and growth of such transplantable tumors as Ehrlich's ascites tumor, sarcoma 37, sarcoma 180 and Zajdela's hepatoma as well as of dimethylbenzanthracene- and benzo(a)pyrene-induced cancer. In a subgroup of animals who had been vaccinated once or twice prior to inoculation of cells, a significant inhibition of growth of tumors of all the histologies except sarcoma 180 was observed alongside with a decrease in tumor incidence and partial resorption of ascitic fluid. Preliminary vaccination of rats interfered with dimethylbenzanthracene- and benzo(a)pyrene-induced carcinogenesis reducing tumor incidence and assuring longer latent period and slower progression of cancer.
Mkrtchian
L N
LN
Ter-Pogosian
E R
ER
Nersesian
A K
AK
Petanova
E V
EV
Martirosian
S O
SO
D000818:Animals; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D014020:Tissue Extracts / Q000276:immunology*; D014470:Umbilical Cord; D014611:Vaccination
D014020:Tissue Extracts
Protivoopukholevoe deĭstvie ékstrakta pupoviny chelovecheskogo ploda.