[The possibilities for enhancing the immunogenicity of adenovirus hexon].
Synthetic polyelectrolytes and muramyldipeptide derivatives are tested as immunostimulators. It is established that the level of antibody-forming cells and specific (virus-neutralizing and precipitating) antibodies considerably rises during the immunization of human adenovirus I hexon in the combination with N-acetylglucosaminyl-muramyldipeptide and conjugation with a copolymer including acrylic acid and N-vinylpyrrolidone. A more expressed intensification of the antibody-formation is observed with the use of polyelectrolytes.
Tarasishin
L A
LA
Diachenko
N S
NS
Nekrasov
A V
AV
Lel'chuk
S V
SV
Andronova
T M
TM
D000260:Adenoviruses, Human / Q000276:immunology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002213:Capsid / Q000276:immunology* / Q000302:isolation & purification; D036022:Capsid Proteins; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus
Vozmozhnosti povysheniia immunogennosti geksona adenovirusov.