Mojave rattlesnake (Crotalus scutulatus scutulatus) venom: in vitro effect on platelets, fibrinolysis, and fibrinogen clotting.
Rattlesnake envenomation commonly produce defects in the hemostatic mechanism. However, Mojave rattlesnake (Crotalus scutulatus scutulatus) envenomation has been reported not to cause a systemic bleeding diathesis. In this study, whole venom from the Mojave rattlesnake was tested in vitro for fibrinogen clotting activity, ability to induce platelet aggregation, and for fibrinolytic activity. The Mojave venom caused no fibrinogen clotting and it displayed very weak ability to cause platelet aggregation and fibrinolytic activity. These in vitro studies support the clinical observation that Mojave envenomation does not cause a coagulopathy.
Corrigan
J J
JJ
Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724.
Jeter
M A
MA
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D003435:Crotalid Venoms / Q000097:blood / Q000633:toxicity*; D005340:Fibrinogen / Q000502:physiology; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects
D003435:Crotalid Venoms; D005340:Fibrinogen