[Effect of subcutaneous administration of liposomes on the functional state of the organs and systems in experimental animals].
Based on the study of subcutaneous injection of lecithin-cholesterol liposomes, its possible toxic effect is discussed and the effect threshold is determined. It is shown, that long-term subcutaneous liposome administration is attended with hepatic cell damage. One or two injections of the preparation does not cause a toxic lesion of the viscera and may be used for therapeutic purposes. A considerable threshold-subthreshold dosage range allows for vast variability of administered liposome amounts.
Sergeev
S G
SG
Gilev
A F
AF
Ust'iantseva
I M
IM
Golubchikova
N A
NA
D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D011817:Rabbits; D051381:Rats
D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol
Vliianie podkozhnogo vvedeniia liposom na funktsional'noe sostoianie organov i sistem éksperimental'nykh zhivotnykh.