title: Lack of interaction between famotidine and warfarin.
abstract: In eight healthy male volunteers taking daily subtherapeutic doses of warfarin (mean daily dose = 4.0 mg), the addition of famotidine 40 mg once-a-day for seven days did not alter the prothrombin time profile, thrombotest coagulation time or total warfarin steady-state plasma concentration. Plasma peak concentration, time to peak concentration and area under curve for famotidine were not affected by the co-administration of warfarin. However the plasma half-life of famotidine was slightly, but statistically significantly longer (p less than 0.05) during maintenance treatment with warfarin (mean +/- s.e.m.: 2.58 +/- 0.14 h versus 2.96 +/- 0.16 h respectively).
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, University of Leuven, School of Medicine, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: De Lepeleire
authors.forename: A
authors.initials: A
authors.lastname: Van Hecken
authors.forename: R
authors.initials: R
authors.lastname: Verbesselt
authors.forename: T B
authors.initials: TB
authors.lastname: Tjandra-Maga
authors.forename: A
authors.initials: A
authors.lastname: Buntinx
authors.forename: L
authors.initials: L
authors.lastname: Distlerath
authors.forename: P J
authors.initials: PJ
authors.lastname: De Schepper
mesh_terms: D000328:Adult; D004347:Drug Interactions; D015738:Famotidine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006706:Homeostasis; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D013997:Time Factors; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D014859:Warfarin; D015738:Famotidine