Effect of clindamycin on adherence of coagulase-negative Staphylococcus to surgical nets.
The authors studied the effect that a subinhibitory concentration of Clindamycin has on adherence of coagulase negative S. epidermidis to surgical nets. Clindamycin, as expected, interferes with the adhesivity to the nets of coagulase-negative S. epidermidis slime producing when sub-MICs are used. The documentation obtained by scanning electron microscope, after treatment of the strains with doses of Clindamycin equal to 1/6 of the MIC after 3 and 6 hours, confirms the anti-adherent effect of the antibiotic.
Gismondo
M R
MR
Institute of Microbiology, University of Catania, Italy.
Chisari
G
G
Lo Bue
A M
AM
Lupo
G
G
D001422:Bacterial Adhesion / Q000187:drug effects*; D002981:Clindamycin / Q000494:pharmacology*; D003030:Coagulase; D015169:Colony Count, Microbial; D004866:Equipment Contamination; D008855:Microscopy, Electron, Scanning; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000472:pathogenicity; D013499:Surface Properties; D013526:Surgical Mesh; D013997:Time Factors
D003030:Coagulase; D002981:Clindamycin