title: Hürthle cell medullary carcinomas of the thyroid gland.
abstract: Two medullary carcinomas of the thyroid (MCTs) composed entirely of Hürthle (oncocytic or oxyphilic) cells and containing follicular structures are described. Immunocytochemical analysis showed these tumours to be calcitonin-, carcino-embryonic antigen- and neuron-specific enolase-positive. The essence of this communication is twofold. Firstly, it highlights and draws attention to this unusual variant of MCT, which may be encountered at frozen section and misdiagnosed as a Hürthle cell tumour of follicular cell origin. Secondly, it undertakes a concise overview of the immunocytochemistry of Hürthle cell thyroid neoplasms and MCT.
authors.affiliation: Department of Anatomical Pathology, University of Cape Town and Groote Schuur Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Chetty
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*