title: Film dosimetry analyses on the effect of gold shielding for iodine-125 eye plaque therapy for choroidal melanoma.
abstract: One of the methods currently being used to treat choroidal melanoma employs an episcleral plaque containing I-125 radioactive seeds. However, comprehensive dosimetry studies on the plaque are scarce and controversial. For this work, we use film to study the dosimetry outside the lip of the gold shield of the eye plaque. This lip around the gold shield was made to protect the critical structures behind and adjacent to the lesion. Since the changes of energy spectrum of I-125 in tissue are negligible, film dosimetry seems to be a logical choice because of high spatial resolution required around the lip of the gold plaque. For this study, we first established an H and D curve with dose expressed in a unit of specific dose rate constant. This avoids absolute dose measurements. All film density measurements are made with a 1-mm aperture scan, normalized to the density at the prescription point for tumor of 3-5-mm apical height, i.e., 5 mm from the interior surface of sclera, and converted to percentage isodose curves. With a gold shield, it is found that when the plaque is placed against the optical nerve, the optical disk and macula, located at 2 mm outside the lip, on the exterior surface of sclera, may receive 85% of the prescription dose for a 12-mm plaque and 58% for a 16-mm plaque. For tumors of 8-mm apical height, the optical nerve would receive more than the prescription dose.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh, School of Medicine, Pennsylvania.
authors.forename: A
authors.initials: A
authors.lastname: Wu
authors.forename: F
authors.initials: F
authors.lastname: Krasin
mesh_terms: D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000532:radiotherapy*; D005373:Film Dosimetry; D006046:Gold; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008545:Melanoma / Q000532:radiotherapy*; D011835:Radiation Protection
chemical_list: D007457:Iodine Radioisotopes; D006046:Gold