title: [Adverse reactions of antituberculous agents, especially about its onset and duration].
abstract: We examined the adverse reactions of the antituberculous agents in 225 hospitalized patients (150: male, 75: female, average age: 45.4 years old) and the results were summarized as follows: 1) The side effects were seen in 53 patients (23.6%), and the abnormal laboratory findings were observed in 94 patients (41.8%). 2) The incidence of adverse reactions in patients treated with three drugs (INH, RFP, EB) and four drugs (plus SM) were 45.9% and 82.4%, respectively. 3) Adverse reaction appeared within one month after starting treatment in 67.9% of eligible patients, and it disappeared within one month from its onset in 76.8% of patients. There results suggested the importance of careful clinical observation especially soon after starting antituberculous therapy.
authors.affiliation: 2nd Department of Internal Medicine, Nagasaki University, School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Yasuoka
authors.forename: K
authors.initials: K
authors.lastname: Sasayama
authors.forename: Y
authors.initials: Y
authors.lastname: Doutsu
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Kohno
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Hirota
authors.forename: K
authors.initials: K
authors.lastname: Hara
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004064:Digestive System / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000995:Antitubercular Agents