title: Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen.
abstract: Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.
authors.affiliation: Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia.
authors.forename: E
authors.initials: E
authors.lastname: Hamsíková
authors.forename: H
authors.initials: H
authors.lastname: Závadová
authors.forename: L
authors.initials: L
authors.lastname: Kutinová
authors.forename: V
authors.initials: V
authors.lastname: Ludvíková
authors.forename: V
authors.initials: V
authors.lastname: Krchnák
authors.forename: S
authors.initials: S
authors.lastname: Némecková
authors.forename: V
authors.initials: V
authors.lastname: Vonka
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; C050807:presurface protein 2, hepatitis B surface antigen