Airways hyperreactivity, bronchial inflammation and obstructive lung disease.
Understanding the mechanisms responsible for the development of chronic airflow obstruction is very important since this disease is the fifth leading cause of death in the United States and it produces a significant economic and social burden for society. Since reversal of established airflow obstruction is not possible, it would appear that the best prognosis and therapeutic results can be obtained by early diagnosis and prevention of irreversible disease. Understanding the underlying pathophysiologic mechanisms is necessary to detect susceptible individuals and develop effective interventions.
Bleecker
E R
ER
Department of Pulmonary and Critical Care Medicine, University of Maryland, School of Medicine, Baltimore.
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D001991:Bronchitis / Q000503:physiopathology*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D012137:Respiratory System / Q000503:physiopathology*