Effects of the new centrally acting muscle relaxant 7-chloro-N,N,3-trimethylbenzo[b]furan-2-carboxamide on motor and central nervous systems in rats.
Effects of KW-6629 (7-chloro-N,N,3-trimethylbenzo[b]furan-2-carboxamide) were studied with special reference to the effect on motor and central nervous systems using rats. The drug effectively reduced the motor coordination (rotarod), the anemic decerebrate rigidity, the crossed extensor reflex, and the gamma-activity indirectly recorded from muscle afferent discharges without showing the direct inhibitory effect on muscle spindles. KW-6629 depressed the polysynaptic and dorsal root reflexes without showing marked effect on the monosynaptic reflex in intact spinal cord rats. KW-6629 produced high-amplitude slow wave in the cerebral cortex in electroencephalogram (EEG). KW-6629 did not reduce the EEG after-discharges and behavioral convulsion (amygdaloid kindling). KW-6629 had no effect on the neuromuscular junction. These results suggest that KW-6629 is a centrally acting muscle relaxant which has a site of action in supraspinal structures.
Ono
H
H
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Saito
K
K
Kondo
M
M
Morishita
S
S
Kato
K
K
Hasebe
Y
Y
Nakayama
M
M
Kato
F
F
Nakamura
T
T
Satoh
M
M
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D003655:Decerebrate State; D004569:Electroencephalography; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009127:Muscle Rigidity / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects
D001572:Benzofurans; D009125:Muscle Relaxants, Central; C065882:7-chloro-N,N-3-trimethylbenzo(b)furan-2-carboxamide