[Polyanions inhibit the binding of autoantibodies with some cellular proteins].
Effect of polyanions on reaction of the Ig from sera of patients with systemic lupus erythematosus and scleroderma with cellular proteins was studied by immunoblotting. It has been shown that dextran sulfate, heparin, denatured DNA and poly I inhibited the binding of autoantibodies with some polypeptides. The molecular weight of these antigens was determined. The molecular mechanism of immunological reactions studied and it's role in pathogenesis of autoimmune diseases is discussed.
Griaznova
Iu B
IuB
Kabakov
A E
AE
Brovkina
L N
LN
Saenko
V A
VA
Nasonov
E L
EL
Poverennyĭ
A M
AM
D001323:Autoantibodies / Q000032:analysis*; D004247:DNA / Q000494:pharmacology*; D016264:Dextran Sulfate / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D015151:Immunoblotting; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000276:immunology; D009691:Nucleic Acid Denaturation; D010455:Peptides / Q000378:metabolism; D011069:Poly I / Q000494:pharmacology*; D011485:Protein Binding; D012595:Scleroderma, Systemic / Q000209:etiology / Q000276:immunology
D001323:Autoantibodies; D010455:Peptides; D011069:Poly I; D006493:Heparin; D004247:DNA; D016264:Dextran Sulfate
Polianiony ingibiruiut sviazyvanie autoantitel s nekotorymi kletochnymi belkami.