3H-imipramine binding to previously frozen platelet membranes from depressed patients, before and after treatment.
3H-imipramine binding in 39 drug-free patients with major depression and 44 healthy controls did not differ significantly between the two groups, in male or female subjects or in subgroups of depressed patients divided by endogenicity or dexamethasone suppression test result. 3H-imipramine binding in depressed patients drug-free for less than three weeks did not differ from those drug-free for longer intervals or from controls. A significant seasonal variation of 3H-imipramine Bmax was found, with lower values in summer and autumn. Treatment of depressed patients with imipramine or lofepramine for six weeks increased KD and Bmax. Methodological modification (in preparation and storage of platelets) does not explain the major differences in results between this study (using frozen platelets), a previous one (using freshly prepared platelets) and others in general, although it might contribute to the range of values reported.
Healy
D
D
Department of Psychiatry, University of Cambridge.
Theodorou
A E
AE
Whitehouse
A M
AM
Lawrence
K M
KM
White
W
W
Wilton-Cox
H
H
Kerry
S M
SM
Horton
R W
RW
Paykel
E S
ES
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D015331:Cohort Studies; D003866:Depressive Disorder / Q000097:blood* / Q000628:therapy; D003907:Dexamethasone; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007099:Imipramine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008127:Lofepramine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D012621:Seasons
D003907:Dexamethasone; D008127:Lofepramine; D007099:Imipramine; D006854:Hydrocortisone