In vivo recruitment of GM-CSF-response myelopoietic progenitor cells by interleukin-3 in aplastic anemia.
Previous studies have indicated that colony-stimulating factors may stimulate myelopoiesis and thus increase the number of circulating white blood cells in patients with hematopoietic failure including aplastic anemia. However, long-term administration of the factor was required to maintain its response. In the present article we report on a patient with severe aplastic anemia undergoing treatment with recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-CSF). After an initial response, the patient became refractory to GM-CSF. However, treatment with interleukin (IL)-3 restored responsiveness to GM-CSF, suggesting that IL-3 may have replenished the bone marrow with myelopoietic progenitor cells sensitive to the action of GM-CSF. This observation suggests the value of application of sequentially acting hematopoietic growth factors in aplastic anemia patients.
Herrmann
F
F
Department of Internal Medicine I, University of Freiburg, F.R.G.
Lindemann
A
A
Raghavachar
A
A
Heimpel
H
H
Mertelsmann
R
R
D000741:Anemia, Aplastic / Q000097:blood / Q000473:pathology / Q000628:therapy*; D001853:Bone Marrow / Q000473:pathology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use*; D007958:Leukocyte Count; D008875:Middle Aged; D009504:Neutrophils; D010865:Pilot Projects; D011994:Recombinant Proteins / Q000627:therapeutic use
D007377:Interleukin-3; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor