Insulin-like growth factor 1 supports embryonic nerve cell survival.
Insulin-like growth factor 1 (IGF-1) is shown to support the long term survival of embryonic chicken central nervous system neurons cultured in a defined medium. This trophic activity for IGF-1 was discovered as the result of its presence as a contaminant in bovine serum albumin, a reagent frequently used in primary cultures of neuronal tissue. The observation that IGF-1 has cell survival activity may explain the high level of IGF-1 receptors found in embryonic brain.
Svrzic
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Salk Institute for Biological Studies, San Diego, CA 92138-9216.
Schubert
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D000818:Animals; D001921:Brain / Q000166:cytology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D002642:Chick Embryo; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology
D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D012710:Serum Albumin, Bovine; D007334:Insulin-Like Growth Factor I