Chromosome aberrations induced by etoposide (VP-16) are not random.
The clastogenic effect of etoposide, an anti-cancer chemotherapeutic drug, was investigated in vitro on lymphocytes of 5 healthy donors. The analysis of the first division metaphases arising after mutagenesis in G1 phase shows that chromosome-type aberrations are much more frequent than chromatid-type lesions. The distribution in relation to chromosome lengths of the 439 breakpoints that were accurately identified is not random: chromosomes 1, 11 and 17 are most frequently involved, while chromosomes 4, 5 and X are seldom affected. This non-random distribution may be related to chromosome structure, since R-band-rich chromosomes are significantly more affected than G-band-rich chromosomes.
Maraschin
J
J
C.N.R.S. URA 620, Institut Curie, Section de Biologie, Paris, France.
Dutrillaux
B
B
Aurias
A
A
D000328:Adult; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002878:Chromosomes, Human, Pair 1 / Q000187:drug effects; D002880:Chromosomes, Human, Pair 11 / Q000187:drug effects; D002886:Chromosomes, Human, Pair 17 / Q000187:drug effects; D002894:Chromosomes, Human, Pair 4 / Q000187:drug effects; D002895:Chromosomes, Human, Pair 5 / Q000187:drug effects; D005047:Etoposide / Q000097:blood / Q000633:toxicity*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D014960:X Chromosome / Q000187:drug effects
D005047:Etoposide