Steady state plasma [3H]-noradrenaline kinetics in quadriplegic chronic spinal cord injury patients.
1. Steady state plasma noradrenaline kinetics were measured in eight male quadriplegic patients and in eight age and sex matched controls. 2. Plasma noradrenaline levels were significantly lower in quadriplegic patients compared to controls. Noradrenaline spillover rate was markedly reduced in quadriplegics compared to controls while noradrenaline clearance was similar in both groups. 3. Noradrenaline kinetics in quadriplegic patients differ from peripheral autonomic neuropathy patients where reductions in both the spillover and clearance of noradrenaline are present.
Krum
H
H
Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Brown
D J
DJ
Rowe
P R
PR
Louis
W J
WJ
Howes
L G
LG
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole; D006801:Humans; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D011782:Quadriplegia / Q000097:blood* / Q000209:etiology; D013119:Spinal Cord Injuries / Q000097:blood* / Q000150:complications; D013599:Systole; D014316:Tritium
D014316:Tritium; D009638:Norepinephrine