title: Electron microscopic immunogold cytochemistry reveals chromogranin A confined to secretory granules of porcine Merkel cells.
abstract: By ultrastructural immunohistochemistry using the immunogold technique, immunoreactive (ir) Chromogranin A (CGA) was found to be confined to the secretory vesicles of porcine Merkel cells. CGA was present predominantly in the periphery of the electron-dense core and on the clear halo. These findings indicate that CGA is a regular constituent of Merkel cell secretory granules but probably not exclusively responsible for their electron opacity.
authors.affiliation: Universitäts-Hautklinik, Heidelberg, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Hartschuh
authors.forename: E
authors.initials: E
authors.lastname: Weihe
authors.forename: U
authors.initials: U
authors.lastname: Egner
mesh_terms: D000818:Animals; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006046:Gold; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009490:Neurosecretory Systems / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D012867:Skin / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D013552:Swine
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D006046:Gold