title: [Effectiveness of depin-E in patients with chronic bronchitis].
abstract: Acute course and long-term regimens of depin-E administration were evaluated clinically and pharmacologically in 50 patients with chronic obstructive bronchitis (COB) and chronic cor pulmonale (CCP). The drug has three mechanisms of action: arteriolovenodilating, bronchodilating, direct pulmonary vascular. Therapeutic effect was achieved in 80% and 60% of COB and CCP patients, respectively. No response was demonstrated for patients with severe cardiac failure. Depin-E can be recommended for prophylaxis and treatment of CCP, to arrest hypertension crises in lesser circulation, to improve pulmonary circulation, central hemodynamics, exercise tolerance.
authors.forename: V A
authors.initials: VA
authors.lastname: Orlov
authors.forename: L I
authors.initials: LI
authors.lastname: Zavolovskaia
authors.forename: I P
authors.initials: IP
authors.lastname: Zamotaev
authors.forename: M G
authors.initials: MG
authors.lastname: Venediktova
authors.forename: V I
authors.initials: VI
authors.lastname: Sokolova
mesh_terms: D000328:Adult; D001980:Bronchi / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; C066007:Depin-E; D009543:Nifedipine
vernacular_title: Effektivnost' depina-E u bol'nykh khronicheskim bronkhitom.