Long-term toxicity/carcinogenicity of musk xylol in B6C3F1 mice.
The long-term toxicity/carcinogenicity of musk xylol, a synthetic nitro musk, was examined in B6C3F1 mice of both sexes. Musk xylol was administered at dietary levels of 0 (control), 0.075 or 0.15% for 80 wk. The overall tumour incidences in all treated groups of both sexes were significantly higher than those in the corresponding controls. Combined malignant and benign liver cell tumours were clearly increased in both sexes, and in males a positive significant trend was also noted for the occurrence of hepatocellular carcinomas. In males the incidence of Harderian gland tumours was also significantly greater in treated groups than in controls. Some other neoplasms, such as lung tumours in both sexes and Harderian gland tumours and lymphomas in females, occurred in greater numbers in the treated groups, although the differences were not statistically significant in comparison with the controls. In addition, the incidences and total numbers of malignant tumours were significantly increased in treated groups of both sexes, although the increases were not dose dependent. The results demonstrated that musk xylol is carcinogenic in B6C3F1 mice when given at dose levels of 0.075 or 0.15% in the diet for 80 wk.
Maekawa
A
A
Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Matsushima
Y
Y
Onodera
H
H
Shibutani
M
M
Ogasawara
H
H
Kodama
Y
Y
Kurokawa
Y
Y
Hayashi
Y
Y
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014992:Xylenes / Q000633:toxicity*
D002273:Carcinogens; D014992:Xylenes; C031447:musk xylene