title: Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection.
abstract: BACKGROUND
  Peliosis hepatis is characterized by cystic, blood-filled spaces in the liver and is seen in patients with chronic infections or advanced cancer and as a consequence of therapy with anabolic steroids. Cutaneous bacillary angiomatosis is a bacterial infection that occurs in patients with human immunodeficiency virus (HIV) infection; its histologic appearance is that of a pseudoneoplastic vascular proliferation.
  
  
  METHODS
  We studied liver tissue from eight HIV-infected patients with peliosis hepatis, two of whom also had cutaneous bacillary angiomatosis. For comparison we examined tissue from four patients who had peliosis hepatis without HIV infection. Tissues were examined histologically on routine sections and with special stains and electron microscopy.
  
  
  RESULTS
  The histologic features seen in peliosis hepatis associated with HIV infection, but not in the four cases unrelated to HIV infection, were myxoid stroma and clumps of a granular purple material that on Warthin-Starry staining and electron microscopy proved to be bacilli. The bacilli, which could not be cultured, were morphologically identical to those found in the skin lesions of cutaneous bacillary angiomatosis. The clinical courses of two of the patients with this "bacillary peliosis hepatis" indicate that it responds to antibiotic treatment.
  
  
  CONCLUSIONS
  HIV-associated bacillary peliosis hepatis is an unusual, treatable opportunistic infection, probably caused by the same organism that causes cutaneous bacillary angiomatosis. Our failure to find bacilli in non-HIV-associated cases implies that other pathogenetic mechanisms may also be responsible for peliosis hepatis.
authors.affiliation: Department of Pathology, University of California, San Francisco.
authors.forename: L A
authors.initials: LA
authors.lastname: Perkocha
authors.forename: S M
authors.initials: SM
authors.lastname: Geaghan
authors.forename: T S
authors.initials: TS
authors.lastname: Yen
authors.forename: S L
authors.initials: SL
authors.lastname: Nishimura
authors.forename: S P
authors.initials: SP
authors.lastname: Chan
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Kennedy
authors.forename: G
authors.initials: G
authors.lastname: Honda
authors.forename: A C
authors.initials: AC
authors.lastname: Stoloff
authors.forename: H Z
authors.initials: HZ
authors.lastname: Klein
authors.forename: R L
authors.initials: RL
authors.lastname: Goldman
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000798:Angiomatosis / Q000150:complications; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents