title: Expression of the ganglioside GD3 in human meningiomas is associated with monosomy of chromosome 22.
abstract: The ganglioside composition of 59 meningiomas has been compared with a molecular genetic analysis of chromosome 22 in the same specimens. Major gangliosides were GM3 (II3NeuAc-LacCer) and/or GD3 [II3(NeuAc)2-LacCer]. In specimens with no or partial deletions of chromosome 22, the GM3 ganglioside predominated, and the mean value for GM3, 61% of total sialic acid, was around four times higher than that for GD3. A loss of chromosome 22, found in 56% of the specimens, was shown to be associated with an increase in the proportion of ganglioside GD3, with the ratio between mean values of GM3 and GD3 being approximately 1:1. Logistic regression revealed that the probability of predicting monosomy of chromosome 22 by the GD3 proportion was 66%.
authors.affiliation: Department of Psychiatry and Neurochemistry, St. Jörgen Hospital, Hisings Backa, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Fredman
authors.forename: J
authors.initials: J
authors.lastname: Dumanski
authors.forename: P
authors.initials: P
authors.lastname: Davidsson
authors.forename: L
authors.initials: L
authors.lastname: Svennerholm
authors.forename: V P
authors.initials: VP
authors.lastname: Collins
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005679:G(M3) Ganglioside / Q000378:metabolism; D005732:Gangliosides / Q000378:metabolism*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008579:Meningioma / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009006:Monosomy; D009994:Osmolar Concentration; D012044:Regression Analysis
chemical_list: D005679:G(M3) Ganglioside; D005732:Gangliosides; C026226:ganglioside, GD3