title: Bone mineral mass associated with postmenopausal vertebral deformities.
abstract: Vertebral morphometry on thoracic and lumbar spine radiographs and bone mass measurements were carried out on 215 patients investigated for postmenopausal osteoporosis. Bone mineral mass was measured on the central third of the skeleton by neutron activation analysis and the result, normalized for body size, expressed as a calcium bone index (CaBI). The normal CaBI value for females (20-40 years) is 0.97 (0.11) with a lower limit for these young, normal women, of 0.75. Vertebral compression deformity was defined as a mean height more than 15% lower than adjacent normal vertebrae. Thoracic and lumbar anterior wedge deformities and central compression were defined as anterior/posterior (A/P) or mid/posterior (M/P) height ratios of less than 0.75. For the 129 patients without vertebral deformities, the mean CaBI was 0.80 (0.12) (1 SD) and 32% of these patients had CaBI values below the normal young adult range (CaBI less than 0.75). In 20 patients, vertebral deformities were limited to 1 or 2 mid-thoracic vertebrae, and the mean CaBI values for these 20 patients was 0.81 (0.15), equal to that for patients without any vertebral deformity. For the remaining 67 patients, (i.e., patients with one or more vertebral deformities involving at least one distal thoracic or one lumbar vertebra) the mean CaBI value was 0.66 (0.10), 17% below the value for patients without vertebral deformities. Low CaBI values (CaBI less than 0.75) were observed in 87% of these patients, consistent with the diagnosis of osteoporotic fractures. Based on our CaBI results, however, mid-thoracic deformity was not associated with significant osteopenia and is not, therefore, diagnostic of osteoporotic fracture.
authors.affiliation: Department of Medicine, University of Toronto, Ontario, Canada.
authors.forename: J E
authors.initials: JE
authors.lastname: Harrison
authors.forename: N
authors.initials: N
authors.lastname: Patt
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: T A
authors.initials: TA
authors.lastname: Bayley
authors.forename: F H
authors.initials: FH
authors.lastname: Budden
authors.forename: R G
authors.initials: RG
authors.lastname: Josse
authors.forename: T M
authors.initials: TM
authors.lastname: Murray
authors.forename: W C
authors.initials: WC
authors.lastname: Sturtridge
authors.forename: A
authors.initials: A
authors.lastname: Strauss
authors.forename: S
authors.initials: S
authors.lastname: Goodwin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001842:Bone and Bones / Q000293:injuries; D002114:Calcinosis / Q000473:pathology; D002127:Calcium Isotopes; D002132:Calcium Radioisotopes; D005260:Female; D050723:Fractures, Bone / Q000209:etiology / Q000473:pathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008875:Middle Aged; D009501:Neutron Activation Analysis; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology*; D013904:Thoracic Vertebrae / Q000473:pathology
chemical_list: D002127:Calcium Isotopes; D002132:Calcium Radioisotopes