Evidence of a local immune activation in cystic brain tumors.
The fluid of cystic brain tumors was characterized with regard to the protein content. In most malignant tumors, the concentrations of immunoglobulins G and M (IgG and IgM) were higher relative to other proteins in the cyst fluid than in the serum of the same patient. A markedly elevated ratio of monomeric to pentameric IgM was detected in the cyst fluid of two patients with glioblastomas. The results indicate a local immunoglobulin synthesis in malignant cystic brain tumors. It is hypothesized that higher-than-expected concentrations of IgG and IgM in cyst fluid as compared to plasma are a sign of an ongoing immune response triggered by the tumor.
Boethius
J
J
Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden.
Lefvert
A K
AK
Sidén
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D001927:Brain Diseases / Q000276:immunology* / Q000378:metabolism; D001932:Brain Neoplasms / Q000276:immunology* / Q000378:metabolism; D003560:Cysts / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis
D001798:Blood Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009363:Neoplasm Proteins