title: Long-term effects of cerebellar pathology on cognitive functions.
abstract: Twelve patients with circumscribed chronic neocerebellar lesions but without CT-evidence of forebrain damage (other than the effects of shunting) were investigated for deficits of cognitive functions. Two different mechanisms were considered as possible causes of cognitive impairment: (1) Damage to the dentato-thalamo-cortical projection leading to impairments of cortical functions, and (2) prolonged intracranial pressure resulting in diffuse forebrain damage and subcortical dementia. Patients with lesions in the left neocerebellum showed deficits in cognitive operations in three dimensional space, consistent with the right forebrain dominance for spatial functions. Prolonged intracranial pressure, on the other hand, resulted in a mild overall cognitive impairment.
authors.affiliation: Department of Neurology, Freiburg University, Federal Republic of Germany.
authors.forename: C W
authors.initials: CW
authors.lastname: Wallesch
authors.forename: A
authors.initials: A
authors.lastname: Horn
mesh_terms: D001925:Brain Damage, Chronic / Q000503:physiopathology*; D002526:Cerebellar Diseases / Q000503:physiopathology*; D002528:Cerebellar Neoplasms / Q000601:surgery; D002531:Cerebellum / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology; D006391:Hemangioma / Q000601:surgery; D006394:Hemangiosarcoma / Q000601:surgery; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008527:Medulloblastoma / Q000601:surgery; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D013787:Thalamic Nuclei / Q000503:physiopathology*; D014888:Wechsler Scales