title: Activation of GD3 synthase by sex steroid hormones in cultured rat hepatocytes.
abstract: The influence of sex steroid hormones on the activities of GM3 and GD3 synthases in isolated hepatocytes was studied. Progesterone (0.1 - 2.0 microM), beta-estradiol (0.1 - 1 microM), and testosterone (0.1 - 1 microM) activate GD3 but not GM3 synthase when added directly to hepatocytes cultured in modified William's E medium.
authors.affiliation: Biochemical Institute, University of Freiburg, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Mesarić
authors.forename: K
authors.initials: K
authors.lastname: Decker
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012799:Sialyltransferases / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D012799:Sialyltransferases; C043662:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase; C021343:haematoside synthetase; D004121:Dimethyl Sulfoxide