[Prostatic cancer and growth factors].
Advanced prostatic cancer (PC) involves a serious prognosis. PC cells form growth factors, which affect growth in autocrine or paracrine manner. PC cell lines, hormone dependency, and growth modalities are mentioned. Interference with these model systems by TGF-alpha, TGF-beta and EGF is described. The presence of less characterized growth factors in homogenates and conditioned media from PC cells is mentioned. An abundance of EGF and EGF-receptors has been found in PC compared to BPH samples. New strategies for treatment are outlined.
Roosen
J U
JU
Bispebjerg Hospital, Urologisk afdeling D, København.
D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
D006133:Growth Substances
Prostatacancer og vaekstfaktorer.