[Cyclosporin in dermatology].
Cyclosporin is a potent immunosuppressive agent with a selective and reversible inhibitory effect on helper T lymphocytes functions mainly interleukin-2 production. Cyclosporin has no myelotoxic, mutagenic or teratogenic effect. The drug is effective in preventing organ rejection, as well as in various auto-immune and inflammatory diseases. In dermatology the drug is extremely effective in psoriasis. Low doses (less than 5 mg/kg per day) have to be used to decrease the risk of nephrotoxicity and hypertension.
Salomon
D
D
Clinique de dermatologie, Hôpital cantonal universitaire, Genève.
Halioua
B
B
D003524:Cyclosporins / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*; D012871:Skin Diseases / Q000188:drug therapy*
D003524:Cyclosporins
La cyclosporine en dermatologie.