title: Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein.
abstract: Perfusion in situ of the placenta of intact or previously parathyroidectomized fetal lambs has been used to assess the ability of three mid-molecule fragments of the human parathyroid hormone-related protein (PTHrP) molecule to stimulate the placental transport of calcium and magnesium. PTHrP(67-86 amide) was most effective but some activity was also shown by PTHrP(75-86 amide) and by PTHrP (75-84) in decreasing order. This placental action of PTHrP(67-86 amide) was rapid and could be observed using the placenta from an intact fetus, whereas it was necessary to use the placenta from a previously parathyroidectomized fetus to demonstrate stimulation of placental calcium transport by PTHrP(1-84). PTHrP(67-86 amide) may resemble the molecule that activates the placental calcium pump.
authors.affiliation: Department of Animal Physiology & Nutrition, University of Leeds, Australia.
authors.forename: A D
authors.initials: AD
authors.lastname: Care
authors.forename: S K
authors.initials: SK
authors.lastname: Abbas
authors.forename: D W
authors.initials: DW
authors.lastname: Pickard
authors.forename: M
authors.initials: M
authors.lastname: Barri
authors.forename: M
authors.initials: M
authors.lastname: Drinkhill
authors.forename: J B
authors.initials: JB
authors.lastname: Findlay
authors.forename: I R
authors.initials: IR
authors.lastname: White
authors.forename: I W
authors.initials: IW
authors.lastname: Caple
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D005260:Female; D008274:Magnesium / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D016105:Parathyroidectomy; D010446:Peptide Fragments / Q000494:pharmacology*; D010477:Perfusion; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011506:Proteins / Q000494:pharmacology*; D012756:Sheep
chemical_list: D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; D008274:Magnesium; D002118:Calcium