The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42.
We have used a cDNA encoding the core region of the human glutaminyl-tRNA synthetase to determine the chromosomal localization of the corresponding gene. Southern blots of restricted DNA from a panel of rodent-human cell lines and in situ chromosome hybridization gave identical results showing that the human gene locus for glutaminyl-tRNA synthetase resides on the distal long arm of chromosome 1. There are now nine mapped aminoacyl-tRNA synthetase genes in the human genome.
Kunze
N
N
Fakultät für Biologie der Universität, Konstanz, Federal Republic of Germany.
Bittler
E
E
Fett
R
R
Schray
B
B
Hameister
H
H
Wiedorn
K H
KH
Knippers
R
R
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D015342:DNA Probes / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D008040:Genetic Linkage; D005975:Glutamate-tRNA Ligase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D009693:Nucleic Acid Hybridization / Q000235:genetics
D015342:DNA Probes; D005975:Glutamate-tRNA Ligase