[Natural antibodies, homoreactants and R-proteins in patients with tuberculosis after effective and insufficiently effective chemotherapy].
The cellular receptor decay products R proteins and resultant product-immunoglobulin complexes, homoreactants showing the properties of natural antibodies and natural anti-sheep erythrocyte antibodies were analysed in their dynamics in 116 patients with infiltrative pulmonary tuberculosis. It was found that small homoreactant levels and relatively low titers of R proteins and natural sheep anti-erythrocyte antibodies were typical of patients with a limited process and favorable course due to effective treatment, the parameters being gradually normalized in their dynamics. In patients with a disseminated destructive process running an unfavorable course, all the values were much higher before the treatment and slightly changed during an ineffective therapy. It is suggested that the findings may be useful in the clinical management of pulmonary tuberculosis to predict its course and outcomes and to evaluate the efficacy of chemotherapy.
Vakhidova
G A
GA
Kul'berg
A Ia
AIa
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000276:immunology; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000187:drug effects / Q000276:immunology; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000032:analysis* / Q000187:drug effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000995:Antitubercular Agents; D007074:Immunoglobulin G; D011971:Receptors, Immunologic
Estestvennye antitela, gomoreaktanty i R-belki u bol'nykh tuberkulezom s éffektivnoĭ i nedostatochno éffektivnoĭ khimioterapieĭ.