[Vasopressin effect and pathophysiological analysis on postprandial hypotension].
In order to clarify the effect of arginine vasopressin (AVP) on postprandial hypotension (PPH) in patients with multiple system atrophy, a loading test of 75 g glucose in 225 ml water was performed during infusion of AVP (0.3 U/min). AVP (0.3 U/min) infusion prior to the loading was significantly effective for PPH in all patients: PPH following to oral intake of glucose was completely prevented. We conclude that infusion of AVP maintained circulating systemic blood volumes by reduced portal venous flow (after a reduction of portal venous inflow) as a result of vasoconstrictive effect of AVP on the splanchnic vessels in patients with PPH.
Hakusui
S
S
Department of Neurology, Nagoya University School of Medicine.
Takahashi
A
A
Sugiyama
Y
Y
Koike
Y
Y
Hasegawa
Y
Y
D000328:Adult; D000368:Aged; D001127:Arginine Vasopressin / Q000008:administration & dosage* / Q000494:pharmacology; D004435:Eating; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013152:Splanchnic Circulation / Q000187:drug effects
D001127:Arginine Vasopressin