Binding of anti-DNA antibodies and inhibition of glomerulonephritis in MRL-lpr/lpr mice by heparin.
Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL-lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL-lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low-dose heparin might be useful in preventing renal damage in patients with lupus nephritis.
Naparstek
Y
Y
Hadassah University Hospital, Jerusalem, Israel.
Ben-Yehuda
A
A
Madaio
M P
MP
Bar-Tana
R
R
Schuger
L
L
Pizov
G
G
Neeman
Z V
ZV
Cohen
I R
IR
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D003429:Cross Reactions / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000235:genetics / Q000517:prevention & control*; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008181:Lupus Nephritis / Q000235:genetics / Q000517:prevention & control; D051379:Mice; D009394:Nephritis, Hereditary / Q000235:genetics / Q000517:prevention & control
D000974:Antibodies, Antinuclear; D006493:Heparin