[Immunohistochemical study on epidermal growth factor and its receptor in human pancreatic carcinoma].
We investigated immunohistochemical expressions of the epidermal growth factor (EGF) and the epidermal growth factor receptor (EGFR) in 25 cases of pancreatic carcinoma, including 13 cases of metastatic lymph nodes. EGF and EGFR were stained mainly in the cytoplasm and on the surface of some pancreatic carcinoma cells, with positive rates of 18/25 (72%) and 9/25 (36%) respectively. In all cases EGFR was noted only when EGF was also detected. EGF and EGFR were stained frequently in differentiated types. In metastatic lymph nodes, EGF and EGFR were found in 54% and 15% respectively, and they were detected only when they were also noted in the same patient's primary lesions. EGF and EGFR were found more frequently in Stages III and IV than in Stage II. These results emphasize that EGF and EGFR may promote both the proliferation and the differentiation of human pancreatic carcinoma cells, as in other sites.
Yamanaka
Y
Y
First Department of Surgery, Nippon Medical School, Tokyo, Japan.
Onda
M
M
Uchida
E
E
Kobayashi
T
T
Sasajima
K
K
Tokunaga
A
A
Tajiri
T
T
Egami
K
K
Asano
G
G
D000328:Adult; D000368:Aged; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism*
D004815:Epidermal Growth Factor; D066246:ErbB Receptors