D-penicillamine-induced lupus erythematosus.
We describe a patient who presented with polyarthritis, pleurisy, rash, and a positive antinuclear antibody result after 5 years of D-penicillamine therapy. D-penicillamine-induced antinuclear antibodies were mainly high-titer IgG directed against the (H2A-H2B)-DNA complex. Weak IgM activity with H1 and H2B was also observed. Withdrawal of D-penicillamine therapy resulted in improvement in clinical symptoms and gradual resolution of serologic abnormalities.
Enzenauer
R J
RJ
Rheumatology Service, Fitzsimons Army Medical Center, Aurora, Colorado 80045.
West
S G
SG
Rubin
R L
RL
D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
D001323:Autoantibodies; D010396:Penicillamine