Effective therapy with low dose of oral cyclosporine A and prednisolone for alopecia universalis.
Although alopecia universalis is an incurable disease, we have obtained favorable results using a low dose of 2.5 mg/kg of cyclosporine A and 5 mg/day of prednisolone without adverse effects. We report our clinical experience of the treatment of two cases of alopecia universalis. Immunological examinations showed marked changes in the ratio of T cell subsets in peripheral blood. There was an increase of OKT8 positive cells and NK cells, reduction of IL-2R positive cells. These immunological changes following recovery from alopecia suggest a correlation between immunological disorders and the pathogenesis of this disease (alopecia universalis).
Teshima
H
H
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University.
Kihara
H
H
Nakagawa
T
T
Hori
Y
Y
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D003524:Cyclosporins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*
D003524:Cyclosporins; D011239:Prednisolone