title: Percutaneous excimer laser coronary angioplasty.
abstract: To determine the efficacy of percutaneous excimer laser coronary angioplasty as an adjunct or alternative to conventional balloon angioplasty, 55 patients were studied in a multicenter trial. These patients underwent the procedure using a modification of conventional balloon angioplasty technique. A first-generation, 1.6-mm diameter catheter constructed of 12 individual silica fibers concentrically arranged around a guidewire lumen was used. Catheter tip energy density varied from 35 to 50 mJ/mm2. The mean number of pulses delivered at 20 Hz was 1,272 +/- 1,345. Acute success was defined as a greater than or equal to 20% increase in stenotic diameter and a lumen of greater than or equal to 1 mm in diameter after laser treatment. Acute success was achieved in 46 of 55 (84%) patients. Adjunctive balloon angioplasty was performed on 41 patients (75%). The percent diameter stenosis as determined by quantitative angiography decreased from a baseline of 83 +/- 14 to 49 +/- 11% after laser treatment and to 38 +/- 12% in patients undergoing adjunctive balloon angioplasty. The mean minimal stenotic diameter increased from a baseline of 0.5 +/- 0.4 to 1.6 +/- 0.5 mm after laser treatment and to 2.1 +/- 0.5 mm after balloon angioplasty. There were no deaths and no vascular perforations. One patient (1.8%) required emergency coronary bypass surgery. These data suggest that excimer laser energy delivered percutaneously by specially constructed catheters can safely ablate atheroma and reduce coronary stenoses.
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.
authors.forename: F
authors.initials: F
authors.lastname: Litvack
authors.forename: N L
authors.initials: NL
authors.lastname: Eigler
authors.forename: J R
authors.initials: JR
authors.lastname: Margolis
authors.forename: W S
authors.initials: WS
authors.lastname: Grundfest
authors.forename: D
authors.initials: D
authors.lastname: Rothbaum
authors.forename: T
authors.initials: T
authors.lastname: Linnemeier
authors.forename: L B
authors.initials: LB
authors.lastname: Hestrin
authors.forename: D
authors.initials: D
authors.lastname: Tsoi
authors.forename: S L
authors.initials: SL
authors.lastname: Cook
authors.forename: D
authors.initials: D
authors.lastname: Krauthamer
mesh_terms: D016342:Angioplasty, Laser / Q000009:adverse effects; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000601:surgery; D003331:Coronary Vessels / Q000601:surgery*; D006801:Humans; D011446:Prospective Studies