Influence of patient-related variables on clozapine plasma levels.
The authors investigated the clozapine plasma levels of 148 psychiatric inpatients. Multiple regression analysis revealed a linear relationship between dose of clozapine and plasma concentrations. The analysis showed a significant influence of dose, sex, smoking, weight, and age on the plasma concentrations of clozapine under clinical conditions. These results remained significant when clozapine doses below 150 mg/day and above 500 mg/day were excluded from the analysis.
Haring
C
C
Department of Psychiatry, Innsbruck University Hospital, Austria.
Fleischhacker
W W
WW
Schett
P
P
Humpel
C
C
Barnas
C
C
Saria
A
A
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001835:Body Weight; D003024:Clozapine / Q000008:administration & dosage / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000097:blood* / Q000188:drug therapy; D012737:Sex Factors; D012907:Smoking / Q000523:psychology
D003024:Clozapine