Changes in muscle proteins following different neural lesions.
The influence of various nerve lesions on the relative concentrations of proteins in the extensor digitorum longus (EDL), plantaris (PLN), and soleus (SOL) muscles from adult female rats was examined by electrophoresis on polyacrylamide gels. After cordotomy, levels of myosin light chains Lcs1 and -2 decreased with concomitant increases in Lcf1, -2, and -3 in SOL but not in EDL and PLN. The relative levels of several other proteins in all three muscle types were changed also. Following section of the sciatic nerve, corticospinal tract and removal of the motor cortex, the relative levels of distinct sets of protein bands in all three muscle types were altered. Only a 14,000-dalton protein band appeared to be affected by all four types of lesions. This experimental evidence supports the view that neural influences upon muscle properties are exceedingly complex. Some of these influences may be exerted via separate, central pathways to the motor neurons.
Lee
J C
JC
Department of Biochemistry, University of Texas Health Science Center, San Antonio.
Braun
A M
AM
D000818:Animals; D003714:Denervation; D005260:Female; D006614:Hindlimb; D009044:Motor Cortex / Q000502:physiology; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000294:innervation* / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D011712:Pyramidal Tracts / Q000502:physiology / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology / Q000601:surgery
D009124:Muscle Proteins; D009218:Myosins