[Effect of ethyl ether of apovincaminic acid (Cavinton) on the ototoxic action of sisomicin in guinea pigs].
The aim of this work was to evaluate the protective effect of etyl ether of apovincaminic acid (Cavinton) against the ototoxic effect of sisomycin in the experimental condition. The first group of guinea pigs were given 14 days sisomycin. The second sisomycin and cavinton. The third was the control group. Hearing acuity was tested by the shivering audiometry. The spiral ganglion function was tested by the microphonic potentials and the integrity of cochlea was diagnosed by scanning microscopy. The results pointed out the ototoxicity of sisomycin. There were the deterioration of hearing acuity, lowering of microphonic potentials and degenerative changes in spiral ganglion. The damages were lowered by use of cavinton before the administration of sisomycin.
Kosztyła-Hojna
B
B
Kliniki Otolaryngologicznej AM w Białymstoku.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D009925:Organ of Corti / Q000187:drug effects*; D012853:Sisomicin / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D014748:Vinca Alkaloids / Q000494:pharmacology*
D000927:Anticonvulsants; D014748:Vinca Alkaloids; C013983:vinpocetine; D012853:Sisomicin
Wpływ estru etylowego kwasu apowinkaminowego (cavintonu) na efekt ototoksyczny sisomycyny u świnek morskich.