title: Radiation necrosis of the optic chiasm, optic tract, hypothalamus, and upper pons after radiotherapy for pituitary adenoma, detected by gadolinium-enhanced, T1-weighted magnetic resonance imaging: case report.
abstract: A 26-year-old woman was treated for a prolactin secreting pituitary adenoma by surgery and radiotherapy (5860 rads). Fourteen months later, she developed right hemiparesis and dysarthria. A T1-weighted magnetic resonance imaging scan using gadolinium contrast showed a small, enhanced lesion in the upper pons. Seven months later, she had a sudden onset of loss of vision, and radiation optic neuropathy was diagnosed. A T1-weighted magnetic resonance imaging scan showed widespread gadolinium-enhanced lesions in the optic chiasm, optic tract, and hypothalamus. Magnetic resonance imaging is indispensable for the early diagnosis of radiation necrosis, which is not visualized by radiography or computed tomography.
authors.affiliation: Department of Neurosurgery, University of Kanazawa School of Medicine, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Tachibana
authors.forename: N
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Yamashima
authors.forename: J
authors.initials: J
authors.lastname: Yamashita
mesh_terms: D000236:Adenoma / Q000532:radiotherapy*; D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D005682:Gadolinium; D006801:Humans; D007031:Hypothalamus / Q000473:pathology; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009897:Optic Chiasm / Q000473:pathology; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011149:Pons / Q000473:pathology; D011832:Radiation Injuries / Q000175:diagnosis*; D014795:Visual Pathways / Q000473:pathology*
chemical_list: D005682:Gadolinium