title: Quantification of the reversibility of stress-induced thallium-201 myocardial perfusion defects: a multicenter trial using bull's-eye polar maps and standard normal limits.
abstract: A multicenter trial was performed on 140 patients from four centers to determine the accuracy of quantitative analysis of stress/delayed thallium-201 myocardial tomograms using normal limits to assess the relative amount of reversibility of stress-induced defects. The patients were found to have 85 fixed and 124 reversible defects, as determined by visual interpretation. Reversibility bull's-eye polar maps were compared to gender-matched normal limits from 36 normals. Regions were identified as reversible if their normalized difference between stress and 4 hr greater than 1.5 s.d.s. from the mean normal limits. Overall agreement between experts at multicenter sites and reversibility maps was 73% for reversible defects and 80% of fixed defects. Sensitivity in detecting reversibility was highest for the left circumflex (88%) and lowest for the right coronary (60%). These results indicate that reversibility polar maps and normal limits offer an objective, accurate technique for determining the reversibility of stress-induced perfusion defects.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: E V
authors.initials: EV
authors.lastname: Garcia
authors.forename: E G
authors.initials: EG
authors.lastname: DePuey
authors.forename: R E
authors.initials: RE
authors.lastname: Sonnemaker
authors.forename: H R
authors.initials: HR
authors.lastname: Neely
authors.forename: E E
authors.initials: EE
authors.lastname: DePasquale
authors.forename: W L
authors.initials: WL
authors.lastname: Robbins
authors.forename: W H
authors.initials: WH
authors.lastname: Moore
authors.forename: J
authors.initials: J
authors.lastname: Heo
authors.forename: A S
authors.initials: AS
authors.lastname: Iskandrian
authors.forename: J
authors.initials: J
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed / Q000379:methods; D014481:United States
chemical_list: D013794:Thallium Radioisotopes