[The effect of the antigen-induced splenic suppressor factor on the immune response to different antigens].
Quick-frozen spleen of mice immunized with sheep red blood cells was homogenized and centrifuged. Supernatant was used as a source of suppressor factor (SF). It was shown that SF inhibited antibody immune response to thymus-dependent antigens and delayed hypersensitivity reaction. SF did not inhibit antibody formation to thymus-independent antigen. SF activity disappeared after its treatment with anti-Ig immunosorbent.
Borisov
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VA
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization / Q000379:methods; D007163:Immunosorbent Techniques; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*
D000941:Antigens; D008070:Lipopolysaccharides; D013491:Suppressor Factors, Immunologic
Vliianie antigenindutsirovannogo supressornogo faktora selezenki na immunnyĭ otvet k razlichnym antigenam.