Metabolism of beta-methyl-heptadecanoic acid in the perfused rat heart and liver.
The metabolism of beta-methyl-[1-14C]heptadecanoic acid, a potential myocardial imaging agent, was investigated in perfused hearts and livers from rats. Hepatic uptake is approximately 4.5 times greater than cardiac uptake. In the heart, 66% of beta-methyl-heptadecanoic acid metabolism occurs via omega-oxidation, 33% by esterification and less than 1% via alpha-oxidation. In contrast, 53% of hepatic metabolism of beta-methyl-heptadecanoic acid occurs via alpha-oxidation, 27% via omega-oxidation, and 20% via esterification. Perfusion of hearts and livers with concentrations of beta-methyl-heptadecanoic acid 100 to 1000 times greater than that used for myocardial imaging does not alter any of the physiological and biochemical parameters measured. In the perfused liver, 3-methyl-[1-14C]glutarate was identified as the principal hydrosoluble catabolite of beta-methyl-heptadecanoic acid.
Fink
G D
GD
Department of Biochemistry, University of Montreal, Canada.
Montgomery
J A
JA
David
F
F
Garneau
M
M
Livni
E
E
Elmaleh
D
D
Strauss
H W
HW
Brunengraber
H
H
D000818:Animals; D005227:Fatty Acids / Q000009:adverse effects / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging; D066298:In Vitro Techniques; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; C033637:3-methylheptadecanoic acid