title: [Intensive growth of human melanoma cells in a fibrin clot implanted in immunosuppressed mice].
abstract: BRO human melanoma cells encapsulated within a fibrin clot grew rapidly in mice immunosuppressed (IS) by wholebody irradiation (5.5 or 6.5 Gy). After 8 days growth under the sub-renal capsule (SRC) of IS mice, the tumor volume increased 40-fold on the average, and histological and cytological examination showed that the growth consisted almost entirely of viable tumor cells. Marked tumor growth in IS mice also was observed after intraperitoneal implantation of fibrin clots containing BRO cells. SRC implantation of encapsulated BRO cells in pre-irradiated mice offers a practical and reproducible method for evaluating the growth of human tumors in vivo.
authors.forename: A
authors.initials: A
authors.lastname: Lokshin
authors.forename: N I
authors.initials: NI
authors.lastname: Polianskaia
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mashkovtsev
authors.forename: I V
authors.initials: IV
authors.lastname: Merkulova
authors.forename: V K
authors.initials: VK
authors.lastname: Sokolova
authors.forename: T N
authors.initials: TN
authors.lastname: Gavrilova
mesh_terms: D000818:Animals; D005337:Fibrin; D006801:Humans; D007165:Immunosuppression Therapy; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D013370:Subrenal Capsule Assay; D014407:Tumor Cells, Cultured; D014916:Whole-Body Irradiation
chemical_list: D005337:Fibrin
vernacular_title: Intensivnyĭ rost kletok melanomy cheloveka, implantirovannykh immunodepressirovannym mysham v fibrinovom sgustke.