Salsalate cross-sensitivity in aspirin-sensitive patients with asthma.
Ten aspirin (ASA)-sensitive patients with asthma underwent double-blind, placebo-controlled oral challenges with salsalate followed by ASA-sensitive confirmatory challenges. All 10 patients sustained asthmatic reactions to ASA, but only two developed respiratory reactions to 2 gm of salsalate. In these two patients, repeat confirmatory challenges with 2 gm of salsalate reproduced the same asthmatic reactions. Both patients were desensitized to ASA, and cross-desensitization with 2 gm of salsalate was then achieved. We conclude that salsalate, a weak inhibitor of cyclooxygenase in vitro, is less likely than ASA to induce asthma in known ASA-sensitive patients with asthma but may occasionally cross-react in these patients. Such reactions were mild and easily treated with beta 2-agonists.
Stevenson
D D
DD
Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, Calif. 92037.
Hougham
A J
AJ
Schrank
P J
PJ
Goldlust
M B
MB
Wilson
R R
RR
D000082:Acetaminophen / Q000008:administration & dosage; D000284:Administration, Oral; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000150:complications*; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000150:complications*; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D012459:Salicylates / Q000008:administration & dosage / Q000009:adverse effects*; D013223:Statistics as Topic
D012459:Salicylates; D000082:Acetaminophen; D001241:Aspirin; C014182:salicylsalicylic acid; D006854:Hydrocortisone