Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.
The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.
Widdop
R E
RE
University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Krstew
E
E
Jarrott
B
B
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009467:Neuromuscular Depolarizing Agents; D009620:Nodose Ganglion / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013696:Temperature
D009467:Neuromuscular Depolarizing Agents; D000804:Angiotensin II; D012701:Serotonin; D012504:Saralasin