[Valproic acid and stupor].
A patient treated with valproic acid and phenytoin for complex partial epilepsy developed a stupor at therapeutic serum levels of the anti-epileptic agents. A few days after discontinuation of valproic acid, complete recovery occurred. The pathogenic mechanism involved is still obscure.
Jongsma
M J
MJ
Sint Lucas Ziekenhuis, Afd. Neurologie, Amsterdam.
Snijders
C J
CJ
D004359:Drug Therapy, Combination; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use*; D014474:Unconsciousness / Q000139:chemically induced*; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D014635:Valproic Acid; D010672:Phenytoin
Valproïnezuur en stupor.