Effects of prostaglandins F2 alpha, A2, and their esters in glaucomatous monkey eyes.
The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) of each PG was topically applied twice daily for 5 days. The IOP was measured at 30- or 60-minute intervals for 6 hours after the morning dose each day. A significant (P less than 0.05) reduction of IOP peaked at 5-9 mm Hg below baseline values on the 5th day of treatment for each PG. The ocular hypotensive effect of these PGs progressively became more pronounced during the course of twice-daily dosing, with a significant reduction maintained at least 17 hours after some doses. No more than trace aqueous flare and no cells were observed in any eye during the course of treatment. These findings demonstrate that PGs other than F2 alpha are potent ocular hypotensive agents in primates.
Wang
R F
RF
Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029.
Camras
C B
CB
Lee
P Y
PY
Podos
S M
SM
Bito
L Z
LZ
D000287:Administration, Topical; D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005901:Glaucoma / Q000188:drug therapy*; D007429:Intraocular Pressure / Q000187:drug effects; D008252:Macaca fascicularis; D011454:Prostaglandins A / Q000627:therapeutic use* / Q000633:toxicity
D011454:Prostaglandins A; C064125:prostaglandin A2 isopropyl ester; C041158:prostaglandin F2 isopropyl ester; D015237:Dinoprost; C100008:prostaglandin A2