Effects of antihypertensive drugs on experimental cerebral ischemia in spontaneously hypertensive rats.
The effects of antihypertensive drugs on ischemic cerebral damage were investigated using the bilateral carotid artery occlusion (BCAO) model in SHR. Oral budralazine and nifedipine, at doses that increased cerebral blood flow (CBF) in SHR in our previous study (Tanaka, S. et al., Folia Pharmacol, Japan, 87, 1986), significantly improved cerebral energy failure after the BCAO, but prazosin which does not increase CBF had no effect on the energy failure. These results suggest that the amelioration by these antihypertensive drugs of the energy failure after the BCAO results from its CBF-increasing effects in SHR.
Tanaka
S
S
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Ashida
S
S
Akashi
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002545:Brain Ischemia / Q000503:physiopathology*; D002339:Carotid Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D006830:Hydralazine / Q000031:analogs & derivatives / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D007773:Lactates; D011773:Pyruvates; D006830:Hydralazine; D000255:Adenosine Triphosphate; D009543:Nifedipine; C006153:budralazine