Renal and hemodynamic effects of endothelin in anesthetized dogs.
The effects of endothelin on systemic hemodynamics and renal functions were investigated in anesthetized dogs. Infusion of endothelin at a dose of 1 ng/kg/min decreased renal blood flow and increased renal vascular resistance and filtration fraction. Endothelin at doses higher than 10 ng/kg/min significantly decreased cardiac output, glomerular filtration rate, renal plasma flow, urine volume, and urinary sodium excretion. Mean arterial pressure showed a transient decrease at doses higher than 50 ng/kg/min. These results showed that endothelin in systemic administration has effects on renal functions as well as on systemic hemodynamics.
Tsuchiya
K
K
Department of Medicine, Kidney Center, Tokyo Women's Medical College, Japan.
Naruse
M
M
Sanaka
T
T
Naruse
K
K
Zeng
Z P
ZP
Nitta
K
K
Demura
H
H
Shizume
K
K
Sugino
N
N
D000758:Anesthesia; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004334:Drug Administration Schedule; D016232:Endothelins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D016232:Endothelins