Pivotal role of early and sustained infarct vessel patency in patients with acute myocardial infarction.
Thrombolytic therapy in acute myocardial infarction unequivocally has improved short- and long-term mortality. The fundamental goal of therapy for evolving myocardial infarction is early and sustained infarct vessel recanalization. The mechanisms linking an open artery with improved long-term survival and other clinical outcomes are presented with use of data from extensive clinical trials.
Topol
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EJ
Department of Internal Medicine, University of Michigan Medical School.
Wilson
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VE
D015906:Angioplasty, Balloon, Coronary / Q000592:standards; D003331:Coronary Vessels; D004502:Education, Medical, Continuing; D006801:Humans; D015994:Incidence; D009203:Myocardial Infarction / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013318:Stroke Volume; D015996:Survival Rate; D015912:Thrombolytic Therapy / Q000379:methods / Q000592:standards*; D014654:Vascular Patency