Visual-evoked potentials and electroretinograms in ruminants with thiamine-responsive polioencephalomalacia or suspected listeriosis.
Electrodiagnostic visual testing (electroretinogram [ERG] and visual-evoked potential [VEP]) was performed on 5 ruminants (3 lambs, 1 kid, and 1 steer) with thiamine-responsive polioencephalomalacia (PEM) and on 2 sheep with listeriosis. The lambs and kid had typical clinical signs of PEM, especially blindness. In these animals, the ERG was normal but the VEP was abnormal. Follow-up recordings in the kid and 1 lamb indicated an improvement in VEP recordings accompanying a gradual return of vision after thiamine treatment. Possible subtle changes in VEP peak latencies could not be assessed because of lack of normative VEP data for sheep and goats. All animals had complete return of vision (owner-assessed). The steer did not have signs of blindness, and the ERG and VEP were normal. Changes in VEP accompanying permanent PEM blindness are not known. One sheep with suspected listeriosis had lack of menace response and palpebral and corneal reflexes, but had intact vision. The ERG and VEP were normal. The second sheep with suspected listeriosis had intact menace response and vision, but became acutely blind and died; the ERG was normal, but VEP amplitudes were depressed.
Strain
G M
GM
Department of Veterinary Physiology, Pharmacology, and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803-8420.
Claxton
M S
MS
Olcott
B M
BM
Turnquist
S E
SE
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000503:physiopathology*; D004596:Electroretinography / Q000662:veterinary*; D004678:Encephalomalacia / Q000503:physiopathology / Q000662:veterinary*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy / Q000503:physiopathology*; D006041:Goats; D008088:Listeriosis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000503:physiopathology*; D013831:Thiamine / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
D013831:Thiamine