[Effect of atypical mycobacterial infection on the cell-mediated immunity induced by Mycobacterium bovis BCG in mice. I. Suppression of delayed-type hypersensitivity].
Mycobacterium avium Mino grows well in the lung, spleen or liver of susceptible mice, such as C57BL/6, C57BL/10, and B10 congenics. Infection with Mino inhibited the induction of delayed-type hypersensitivity (DTH) to BCG in the mouse receiving subcutaneous injection of BCG 2 weeks later. Post-infection with Mino did not affect DTH to BCG already established. Preceding infection with avirulent strains of atypical mycobacteria weakly suppressed the induction of DTH by BCG. On the other hand, Mino infection did not affect DTH to SRBC. DTH to Mino and DTH to BCG detected by PPD-I and PPDs hardly showed cross-reactivity. These results suggest that tuberculin skin reaction after BCG vaccination could be suppressed by the infection with atypical mycobacteria in humans, especially where these bacterial infections are prevailing.
Nakamura
R M
RM
Department of Cellular Immunology, National Institute of Health, Tokyo, Japan.
Goto
Y
Y
Kinomoto
M
M
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D008810:Mice, Inbred C57BL; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology*; D009162:Mycobacterium avium / Q000276:immunology*; D009170:Nontuberculous Mycobacteria
D001500:BCG Vaccine