[The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine].
It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.
Bershteĭn
L M
LM
Zabezhinskiĭ
M A
MA
Stukov
A N
AN
Kalikhevich
V N
VN
Mikheev
A M
AM
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D005934:Glucagon / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D007414:Intestinal Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D007420:Intestine, Large; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010418:Pentagastrin / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D006728:Hormones; D014660:Vasoactive Intestinal Peptide; D005934:Glucagon; D000262:Adenylyl Cyclases; D010418:Pentagastrin; D011377:Proglumide
Gormonochuvstvitel'nost' perevivnoĭ adenokartsinomy tolstoĭ kishki.