Chromosomal translocation t(14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin's lymphoma and chronic lymphocytic leukemia: a molecular genetic analysis of 176 cases.
Using a probe for the newly described bcl-3 gene near the breakpoint of the t(14;19), 176 cases of non-Hodgkin lymphoma and B cell chronic lymphocytic leukemia were analyzed. Rearrangement of the bcl-3 gene was found in only one case; a follicular lymphoma involving the salivary gland that had progressed to a diffuse large cell lymphoma. We conclude that rearrangement of the bcl-3 gene as detected by our method occurs rarely in mature B or T cell neoplasms.
van Krieken
J H
JH
Department of Pathology, University Hospital, Leiden, The Netherlands.
McKeithan
T W
TW
Raghoebier
S
S
Medeiros
L J
LJ
Kluin
P M
PM
Raffeld
M
M
D000081242:B-Cell Lymphoma 3 Protein; D002888:Chromosomes, Human, Pair 19; D004273:DNA, Neoplasm / Q000302:isolation & purification; D015321:Gene Rearrangement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D015183:Restriction Mapping; D014157:Transcription Factors; D014178:Translocation, Genetic
D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors