title: [Plasma clearance of cholic acid in patients with chronic diseases of the liver].
abstract: The diagnostic value of 14C-cholic acid plasma clearance following oral administration was evaluated. 14C-cholic acid clearance was 1223 +/- 267 mL/min. per 1 square meter in the control group without liver disease. Significantly lower values (p less than 0.001) were obtained in the patients with chronic hepatitis (694 +/- 137 mL/min. per 1 square meter) and liver cirrhosis (332 +/- 156 mL/min. per 1 square meter). Sensitivity of the 14C-cholic acid clearance test was 100% while specificity--80%. A 3-year follow-up has shown that this test is of high prognostic value in patients with liver cirrhosis.
authors.affiliation: Kliniki Gastroenterologii i Przemiany Materii CMKP w Warszawie.
authors.forename: W
authors.initials: W
authors.lastname: Medrzejewski
authors.forename: A
authors.initials: A
authors.lastname: Habior
authors.forename: B
authors.initials: B
authors.lastname: Samociuk-Medrzejewska
authors.forename: M
authors.initials: M
authors.lastname: Cwikła
mesh_terms: D000328:Adult; D019826:Cholic Acid; D002793:Cholic Acids / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006509:Hepatitis B / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged
chemical_list: D002793:Cholic Acids; D019826:Cholic Acid
vernacular_title: Klirens osoczowy kwasu cholowego u chorych na przewlekłe choroby watroby.