[A method of modeling of occlusion-reperfusion induced myocardial infarction and quantitative evaluation of the effectiveness of limitation of its size].
An experimental mathematical model was proposed to assess the efficiency of experimental myocardial infarction (MI) size limitation. A canine model of occlusion-reperfusion myocardial lesion was used in an acute experiment with an open chest. 90-minute occlusion and 4-hour reperfusion were performed by carotid coronary bypass surgery. The necrotic zone and the risk area were visualized by double perfusion with tetrazolium staining. Retrograde coronary blood flow was used as a measure of collateral blood flow. The multiple linear regression equation with values of the risk zone and retrograde blood flow/risk area ratio used as independent variables enabled the size of myocardial infarction to be highly accurately predicted. Comparison of the true size of MI with the "expected" one provided methods for quantitative assessment of pharmacological limitation of MI sizes. Calculating an individual value for each animal made it possible to examine its relation to coronary circulation parameters and facilitated comparison of benefits from various agents.
Shvilkin
A V
AV
Levitskiĭ
D O
DO
Serebriakova
L I
LI
Tskitishvili
O V
OV
Sadretdinov
S M
SM
D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003331:Coronary Vessels / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D008433:Mathematics; D009203:Myocardial Infarction / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000517:prevention & control; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D011189:Potassium Chloride / Q000008:administration & dosage*; D012044:Regression Analysis
D011189:Potassium Chloride
Metod modelirovaniia okkliuzionno-reperfuzionnogo infarkta miokarda i kolichestvennoĭ otsenki éffektivnosti ogranicheniia ego razmerov.