title: Factors predicting mortality in idiopathic dilated cardiomyopathy.
abstract: A study of factors predicting mortality was performed in 201 patients with dilated cardiomyopathy (163 men, 38 women, mean age: 48 +/- 11 years) by multivariate analysis (Cox Model) of 51 clinical, electrocardiographic, echocardiographic and haemodynamic parameters, 56 patients died during follow-up (mean follow-up: 57.1 +/- 29.9 months). 5 year survival was 77 +/- 3%. The following parameters were independent predictors of mortality: first symptom: pulmonary oedema, peripheral oedema, syncope; duration of symptoms at the time of inclusion; end systolic left ventricular volume; end diastolic left ventricular diameter; pulmonary artery systolic pressure; and their combination had the most accurate predictive value for death. A quantitative score (s) was calculated and used to define three subgroups: A:s less than or equal to 4.5; B: 4.5 less than s less than 6; C:s greater than or equal to 6. Five-year survival was 90 +/- 5% in group A; 84 +/- 4% in B and only 53 +/- 7% in C. In conclusion, overall survival was good in this population of all stage dilated cardiomyopathy; factors related to clinical severity, left ventricular dilation, systolic pulmonary artery pressure and duration of symptoms defined a subgroup of patients with poor prognosis.
authors.affiliation: Department of Cardiology, Pitie Salpetriere Hospital, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Komajda
authors.forename: J P
authors.initials: JP
authors.lastname: Jais
authors.forename: F
authors.initials: F
authors.lastname: Reeves
authors.forename: B
authors.initials: B
authors.lastname: Goldfarb
authors.forename: J B
authors.initials: JB
authors.lastname: Bouhour
authors.forename: Y
authors.initials: Y
authors.lastname: Juillieres
authors.forename: J
authors.initials: J
authors.lastname: Lanfranchi
authors.forename: P
authors.initials: P
authors.lastname: Peycelon
authors.forename: P
authors.initials: P
authors.lastname: Geslin
authors.forename: D
authors.initials: D
authors.lastname: Carrie
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000235:genetics / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate