title: Brain abscess in the 1980s.
abstract: Brain abscess was reviewed in 24 patients admitted to University Hospital, Nottingham over a period of 3 years. Chronic ear infection was the most common predisposing factor, but in 11 patients the focus of infection remained unknown. CT scanning, carried out in all patients, was negative in one patient with clinical signs of meningitis. Polymicrobial and anaerobic infections were common. Actinomyces species were isolated in mixed culture from seven patients; in five the abscess was located in the cerebellum. Therapy was most often a combination of surgical drainage and antimicrobial therapy with beta-lactam agents and metronidazole. Evidence suggests that cefotaxime may offer a suitable alternative to chloramphenicol and benzylpenicillin in the treatment of brain abscess.
authors.affiliation: Department of Neurosurgery, University Hospital, Nottingham, United Kingdom.
authors.forename: F E
authors.initials: FE
authors.lastname: Donald
authors.forename: J L
authors.initials: JL
authors.lastname: Firth
authors.forename: I M
authors.initials: IM
authors.lastname: Holland
authors.forename: D T
authors.initials: DT
authors.lastname: Hope
authors.forename: P
authors.initials: P
authors.lastname: Ispahani
authors.forename: J A
authors.initials: JA
authors.lastname: Punt
mesh_terms: D000196:Actinomycosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003399:Craniotomy; D004322:Drainage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007769:Lactams; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D008795:Metronidazole