title: Madopar HBS in nocturnal symptoms of Parkinson's disease.
abstract: Madopar Hydrodynamically Balanced System (HBS), a new sustained-release levodopa preparation, was used to control severe nightly disabilities in 15 outpatients suffering from Parkinson's disease in an advanced state and with long-term levodopa therapy. This medication was given ante noctem in addition to an otherwise unchanged daily regimen of levodopa administration. In 13 patients a considerable diminution in nocturnal akinesia and in the frequency of waking up was reached with a mean dosage of 308 mg of Madopar HBS. Early morning akinesia was only slightly alleviated in four patients. The nocturnal off-period pain disappeared in one patient. Adverse effects consisted of nocturnal dyskinesia in two patients and early morning dystonia in another two patients. The regular use of sleeping pills was clearly reduced after Madopar HBS therapy.
authors.affiliation: Department of Neurology, Ziekenzorg Hospital, Enschede, The Netherlands.
authors.forename: E N
authors.initials: EN
authors.lastname: Jansen
authors.forename: J D
authors.initials: JD
authors.lastname: Meerwaldtt
mesh_terms: D000328:Adult; D000368:Aged; D001545:Benserazide / Q000008:administration & dosage*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002940:Circadian Rhythm / Q000187:drug effects*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; C005177:benserazide, levodopa drug combination; D007980:Levodopa; D001545:Benserazide; D002262:Carboxy-Lyases