title: Lower oesophageal contractility and detection of awareness during anaesthesia.
abstract: We have investigated the value of lower oesophageal contractility (LOC) in detecting awareness during anaesthesia in 20 human volunteer patients. LOC was measured either with subjects awake or after induction with propofol, during induction with propofol, and then as consciousness returned. Statistically significant changes were observed in the frequency of spontaneous contractions, peak and mean amplitude of spontaneous and provoked contractions, and the oesophageal contractility index as subjects lost consciousness and also as it was regained. The differences in LOC which occurred when subjects were conscious and unconscious support the view that LOC is related to the depth of anaesthesia, but its unreliability at the interface between consciousness and unconsciousness prevents selective detection of awareness, although the response in the presence of painful stimuli has not been tested.
authors.affiliation: Department of Anaesthetics, University Hospital of Wales, Heath Park, Cardiff.
authors.forename: P A
authors.initials: PA
authors.lastname: Isaac
authors.forename: M
authors.initials: M
authors.lastname: Rosen
mesh_terms: D000768:Anesthesia, General / Q000523:psychology*; D001364:Awareness / Q000502:physiology*; D003243:Consciousness / Q000502:physiology; D004947:Esophagus / Q000502:physiology*; D006801:Humans; D007432:Intraoperative Period; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology; D015742:Propofol; D013997:Time Factors
chemical_list: D015742:Propofol