[Use of perfluorocarbon emulsion in kidney transplantation].
Intravenous infusion of perfluorocarbon emulsion (PFCE) during autotransplantation of kidneys which had been stored for 24 hours led to a rapid normalization of intraorganic hemodynamics in dogs, and restoration of ionic homeostasis, energy potential, and functional activity of the transplants. It was shown that the protective effect of PFCE is associated with inhibition of free-radical lipid peroxidation, and the establishment of a stable protein-lipid conformation of the membrane structures of the cells of ischemic organs. It was established that the use of PFCE in the stage of stored kidney transplantation may be an effective method for the prevention of reperfusion damage to the transplant.
Onishchenko
N A
NA
Serniak
P S
PS
Kovalenko
N V
NV
Kalinin
D I
DI
Chernobrivtsev
P A
PA
Berko
E M
EM
D000818:Animals; D015925:Cryopreservation / Q000379:methods*; D004285:Dogs; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods* / Q000502:physiology; D009926:Organ Preservation / Q000379:methods*; D015427:Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors; D014182:Transplantation, Autologous
D004655:Emulsions; D005466:Fluorocarbons
Ispol'zovanie perftoruglerodnoĭ émul'sii pri transplantatsii pochek.