In vivo toxicity of 3'-azido-3'-deoxythymidine (AZT) on CBA/Ca mice.
CBA/Ca male mice were given 3'-azido-3'-deoxythymidine (AZT) in drinking water (1 mg/ml) for up to 7 weeks. Water consumption and body weight decreased significantly. Neutropenia and lymphopenia were observed during and after exposure. Significant macrocytic anemia developed and disappeared as a function of red cell life span after stopping AZT intake. A microthrombocytosis was seen. Bone marrow cellularity and spleen colony-forming unit (CFU-s) content fell, but recovered completely and quickly after terminating AZT intake. Hemopoietic stem cell function measured by 2 different methods of rescuing fatally irradiated mice was normal 4 weeks after AZT exposure, suggesting that AZT treatment does not induce a long-lasting effect in genetic control of mitotic potential of stem cells. This is in marked contrast to exposure of CBA/Ca mice to benzene and ionizing radiation.
Cronkite
E P
EP
Medical Department, Brookhaven National Laboratory, Upton, New York 11973.
Bullis
J
J
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002452:Cell Count / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000139:chemically induced; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D013997:Time Factors; D014867:Water; D015215:Zidovudine / Q000008:administration & dosage / Q000633:toxicity*
D014867:Water; D015215:Zidovudine