title: [Lactic acidosis and hyperlactatemia].
abstract: Lactic acidosis is a relatively frequent acid-base disorder in a hospital setting. It is defined by the association of an arterial pH inferior to 7.35 and an arterial lactate level superior to 5 mmol/l. Classically, 2 types of acidosis are distinguished on the basis of their mechanisms of onset: the type A, with evident clinical signs of tissue hypoperfusion and the type B, more are, without apparent hypoxia. This last category is observed in various circumstances such as diabetes, acute liver failure, poisoning and, more rarely, inborn errors of carbohydrate metabolism. Treatment aims primarily at the correction of the cause. The efficacy of sodium bicarbonate is presently debated, considering the risk to worsen hyperlactatemia and to induce hyperosmolarity or rebound alkalosis. The administration of dichloroacetate, an activator of pyruvate dehydrogenase, permits to correct partially the lactic acidosis but is not harmless especially in case of prolonged administration. Other therapeutic modalities are evoked. Arterial lactate level is a reliable prognostic index of shock, because blood values do not depend only of the oxygen debt but also of the efficacy of hepatic and renal lactate uptake. Sequential measurements are recommended.
authors.affiliation: Département de médecine, Centre hospitalier universitaire vaudois, Lausanne, Suisse.
authors.forename: M
authors.initials: M
authors.lastname: Potin
authors.forename: C
authors.initials: C
authors.lastname: Perret
mesh_terms: D000140:Acidosis, Lactic / Q000145:classification / Q000188:drug therapy / Q000378:metabolism; D001639:Bicarbonates / Q000627:therapeutic use; D003999:Dichloroacetic Acid / Q000627:therapeutic use; D006801:Humans; D007773:Lactates / Q000097:blood* / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D007773:Lactates; D003999:Dichloroacetic Acid
vernacular_title: Acidose lactique et hyperlactatémie.