Effect of dl-fenfluramine on thermic effect of food in humans.
To determine whether dl-fenfluramine increased metabolic rate in humans, hourly indirect calorimetry measurements were made on 16 nonobese males over a 5 h period under each of four conditions: placebo/no meal, placebo/meal, 60 mg dl-fenfluramine/no meal, and 60 mg dl-fenfluramine/meal. Drug administration was double-blind and a Latin square design was used with treatments separated by 7 days. To confirm that active drug was administered when assigned, subjective sensations were measured by questionnaires administered three times during each treatment. Metabolic rate (kcal/min) during the four treatments was compared by analysis of variance over the entire 5 h and at the end of the measurement period. The 750 kcal (3140 kJ) meal increased metabolic rate over the fasting conditions (0.160 +/- 0.035 kcal/min, P less than 0.0005) and the combination of fenfluramine and meal caused a further significant increase beyond that found with placebo and meal (0.072 +/- 0.035 kcal/min, P less than 0.025). At the end of the measurement period, metabolic rate during the placebo/meal treatment had returned to the level of the fasting treatments. In contrast, during the fenfluramine/meal condition, metabolic rate was still elevated (0.173 +/- 0.04 kcal/min, P less than 0.003). The results of this study suggested that fenfluramine increased metabolic rate by potentiating the thermic effect of food.
Troiano
R P
RP
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853.
Levitsky
D A
DA
Kalkwarf
H J
HJ
D000284:Administration, Oral; D000328:Adult; D001481:Basal Metabolism / Q000187:drug effects; D002153:Calorimetry, Indirect; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects*; D005069:Evaluation Studies as Topic; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013997:Time Factors
D005277:Fenfluramine