[Aqueous humor flow measured by fluorophotometry. A comparative study of the effect of various beta-blocker eyedrops in patients with ocular hypertension].
A randomized double-blind study of aqueous humor flow and intraocular pressure measurements before and four hours after instillation of placebo and beta-blocker eyedrops, was carried out in 40 hypertensive patients. The treated and non-treated patients either did or didn't show an optic disc excavation and a visual field defect. Hypertensive patients with a previous tension treatment will stop therapy on a 3-week period up to an increase of their own ocular tension value greater than or equal to 3 mmHg. The intraocular pressure statistically decreased of 20.8% four hours after topical placebo, the aqueous humor flow remaining unchanged. In this study, timolol eyedrops induced a greater decrease of the aqueous humor flow (39%), followed equally by betaxolol (23.8%) and carteolol (20.42%). Timolol and betaxolol eyedrops equally induced a significant decrease of the intraocular pressure. There was no effect of carteolol on the intraocular pressure. The outflow facility was independent of the instilled beta-blocker eyedrop.
Coulangeon
L M
LM
Service d'Ophtalmologie, CHRU, Hôpital Saint-Jacques, Clermont-Ferrand.
Sole
M
M
Menerath
J M
JM
Sole
P
P
D000328:Adult; D000704:Analysis of Variance; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002354:Carteolol / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D015590:Fluorophotometry; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009883:Ophthalmic Solutions; D010919:Placebos; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*
D009883:Ophthalmic Solutions; D010919:Placebos; D013999:Timolol; D002354:Carteolol; D015784:Betaxolol
Débit de l'humeur aqueuse mesuré par fluorophotométrie. Etude comparative de l'effet de différents collyres bêta-bloquants chez des patients ayant une hypertonie oculaire.