title: [A model of experimental acute pancreatitis in the conscious rat].
abstract: We describe an experimental model of acute pancreatitis in conscious rats, based on biliary reflux; sodium deoxycholate was injected while maintaining the common duct (biliary and pancreatic) temporally occluded. A progressive increase of serum amylase, cardiac rate and hematocrit value, as well as a decrease of plasma proteins are characteristic of this experimental model. Blood pressure was maintained until shortly before death, which occurred after 85 minutes. This is a simple model, reliable and reproducible, which requires minimal surgical manipulation.
authors.affiliation: Servicio de Cirugía de Aparato Digestivo, Fundación Jiménez Díaz-CSIC, Universidad Autónoma de Madrid.
authors.forename: J G
authors.initials: JG
authors.lastname: Ais Conde
authors.forename: J M
authors.initials: JM
authors.lastname: López Novoa
authors.forename: C
authors.initials: C
authors.lastname: Novo Alonso
authors.forename: J M
authors.initials: JM
authors.lastname: Romeo Martínez
mesh_terms: D000208:Acute Disease; D000818:Animals; D003135:Common Bile Duct / Q000502:physiology; D003840:Deoxycholic Acid; D004195:Disease Models, Animal; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003840:Deoxycholic Acid
vernacular_title: Modelo de pancreatitis aguda experimental en la rata consciente.