[The effect of a fluorocarbon emulsion--an enzyme inducer of the cytochrome P-450-dependent monooxygenase system of the liver--on the acute toxicity of CCl4 and on the efficacy of the prophylactic use of antidotes in organophosphate pesticide poisoning].
The effect of intraperitoneal administration of perfluorocarbon emulsion, an inducer of cytochrome P-450-dependent monoxygenase system of the liver, on the resistance of rodents to the action of CCl4 and organophosphorus pesticides was studied. Perfluorocarbon emulsion potentiated CCl4 toxicity decreasing LD50 from 4.5 to 3.7 mg/kg mouse body weight without changing susceptibility of rats to organophosphorus pesticides. A preliminary administration of perfluorocarbon emulsion effectively increased the protective action of antidotes (atropine + dipyroxime) providing the resistance of the animals to 12-fold, 20-fold and 20-fold LD50 of dichlophos, methaphos and butiphos, respectively.
Mikhaĭlov
G M
GM
Varykhanov
A A
AA
Omarova
L A
LA
Verovskiĭ
V E
VE
Obraztsov
V V
VV
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000401:mortality; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005466:Fluorocarbons / Q000627:therapeutic use*; D007306:Insecticides / Q000506:poisoning* / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D009943:Organophosphorus Compounds; D010105:Oxygenases / Q000096:biosynthesis*; D011041:Poisoning / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control; D051381:Rats
D000931:Antidotes; D005466:Fluorocarbons; D007306:Insecticides; D009943:Organophosphorus Compounds; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D010105:Oxygenases
Vliianie ftoruglerodnoĭ émul'sii--induktora fermentov tsitokhrom P-450-zavisimosti monooksigenaznoĭ sistemy pecheni--na ostruiu toksichnost' CCl4 i na éffektivnost' profilakticheskogo primeneniia antidotov pri intoksikatsii fosfororganicheskimi pestitsidami.