[Changes in lymphocyte subpopulations induced by the administration of thymopentin].
Modifications of the levels of T-helper (T4) and T-suppressor (T8) lymphocytes were assessed, together with their ratio, in 17 subjects who had received thymopentine as an adjuvant to Hevac-B vaccination. Two months after treatment with the immunomodulating drug, T4 lymphocytes were considerably increased whereas absolute levels of T8 lymphocytes were decreased in the majority of patients: this led to a net increase in the T4/T8 ratio. This finding leads to the conclusion that all subjects produced anti-HBs antibodies as a means of protection.
Garavelli
P L
PL
Divisione di Malattie Infettive, Ospedale Civile, Alessandria.
Ciriello
M
M
D000328:Adult; D005260:Female; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D016305:Thymopentin / Q000494:pharmacology*; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines; D016305:Thymopentin
Modificazioni delle sottopopolazioni linfocitarie indotte dalla somministrazione di timopentina.