title: [Disulfiram-like effect of cefonicid: first observation].
abstract: The disulfiram-like reaction is linked to the assumption of ethyl alcohol during therapy with the cephalosporin latamoxef, cefamandole and cefoperazone. The reaction is commonly ascribed to the methyl-thiotetrazole group, resembling part of the disulfiram molecule. We describe the case of a patient who experienced on two different occasions a disulfiram-like effect during therapy with cefonicid. This cephalosporin contains the methylsulphothiotetrazole group in place of the methylthiotetrazole group. Our observation is the first related to cefonicid.
authors.affiliation: Divisione di Medicina generale, ULSS 17 Veneto, Ospedale, Mirano.
authors.forename: G
authors.initials: G
authors.lastname: Marcon
authors.forename: A
authors.initials: A
authors.lastname: Spolaor
authors.forename: M
authors.initials: M
authors.lastname: Scevola
authors.forename: M
authors.initials: M
authors.lastname: Zolli
authors.forename: G B
authors.initials: GB
authors.lastname: Carlassara
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D015790:Cefonicid / Q000009:adverse effects*; D004221:Disulfiram; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male
chemical_list: D000431:Ethanol; D015790:Cefonicid; D004221:Disulfiram
vernacular_title: Effetto disulfiram-simile da Cefonicid: prima segnalazione.