An experimental model for advanced ovarian cancer.
Intraperitoneally transplanted tumors implanted and began developing with ascites in about 62% of the female rats within 4 to 6 weeks after transplantation. The tumor used in this study was an adenocarcinoma and which originated from a primary ovarian cancer in rats of the same strain (Wistar). The morphology and biological behavior of the tumor were very similar to the tumor in humans. Moreover, the preliminary results with cisplatin therapy indicate that intraperitoneal cancer corresponding to stage III or IV in the FIGO classification is a promising model for experimental therapeutic studies of common epithelial carcinoma at an advanced stage.
Sugiyama
T
T
Department of Obstetrics and Gynecology, Kurume University, School of Medicine, Japan.
Nishida
T
T
Yokota
D
D
Ushijima
K
K
Imaishi
K
K
Hirakawa
N
N
Nakanami
M
M
Oda
T
T
Yakushiji
M
M
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D002945:Cisplatin