[Antioxidant emoxipin: its effect on the formation of a necrotic focus and reparative processes in myocardial infarction].
The effect of the water soluble antioxidant emoxipin given intravenously in a dose of 10 mg/kg for 5 days, then intramuscularly 1 mg/kg for 15 days. Comparison with the values found in the control group of patients with myocardial infarction revealed that emoxipin contributed to limitation of the size of a necrotic focus and accelerated reparative processes, whose result was a lower incidence of circulatory failure. One of the main mechanisms responsible for beneficial effects of emoxipin on the clinical course of myocardial infarction consists in normalization of lipid peroxidation and parameters of the antioxidative status.
Golikov
A P
AP
Ovchinnikov
V L
VL
Polumiskov
V Iu
VIu
Davydov
B V
BV
Karev
V A
VA
Konorev
L A
LA
Shvedova
A A
AA
D000328:Adult; D000975:Antioxidants; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D000975:Antioxidants
Antioksidant émoksipin: vliianie na formirovanie ochaga nekroza i reparativnye protsessy pri infarkte miokarda.