[Toxicity of ethylene oxide on the crystalline lense in an occupational milieu. Difficulty of epidemiologic surveys of cataract].
Ethylene oxide is a sterilizing gas for heat-sensitive materials. Eight cases of subcapsular cataract were attributed to this compound from 1982 to 1985. This epidemiological study was conducted in 55 persons to determine the prevalence of lens opacities and cataracts in workers exposed to this gas. The 21 persons of more than 45 years of age were then compared to 16 non-exposed persons matched for age and gender. Lens opacities (independently of visual acuity) were observed in 19 of the 55 exposed. Among exposed and non-exposed persons of more than 45 years of age, there were no significantly differences with regard to the following characteristics of lens opacities: prevalence (13 in the 21 exposed; 10 in the 16 non-exposed), distribution of the localisations, morphology and importance of the cortical opacities. No link was found between the characteristics of the lens opacities and the characteristics of the exposure: habitual exposure and accidental overexposures. For cataracts, defined by the association of lens opacities and a visual acuity less than 20/25 (this loss not being attributable to another cause), their prevalence differed significantly (p less than 0.05) between the exposed (6 of 21) and the non-exposed (0 of 16). There was no relation between their existence and accidental overexposures. The risk of lens opacification by ethylene oxide, established in cases of massive exposures as previously described, could also exist during chronic exposure to low concentrations, but is to be confirmed by other studies. It could be explained by saturation of the protective mechanisms against alkylating action of this product. This study prompted us to discuss the epidemiological difficulties in studies of cataracts.
Deschamps
D
D
Service de pathologie professionnelle, Hôpital Cochin, Paris.
Leport
M
M
Cordier
S
S
Laurent
A M
AM
Festy
B
B
Hamard
H
H
Renard
G
G
Pouliquen
Y
Y
Conso
F
F
D000818:Animals; D002386:Cataract / Q000139:chemically induced* / Q000453:epidemiology; D003201:Computers; D005027:Ethylene Oxide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors
D005027:Ethylene Oxide
Etude en milieu professionnel de la toxicité de l'oxyde d'éthylène sur le cristallin. Difficulté des enquêtes épidémiologiques sur la cataracte.