Chromosome and SCE analysis in peripheral lymphocytes of persons occupationally exposed to cytostatic drugs handled with and without use of safety covers.
The frequency of structural chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of nurses handling cytostatic drugs without a safety cover is compared with that of individuals doing this work exclusively under a safety cover and with that of nurses working under similar conditions but not handling cytostatics. The mean yield of dicentric chromosomes, (4.3 +/- 0.7)/1000 cells, and acentric fragments, (15.4 +/- 1.4)/1000 cells, in the occupationally exposed group is significantly increased in comparison to individuals working with protection (dic: (1.1 +/- 0.4)/1000 cells, ace: (11.2 +/- 1.2)/1000 cells) and nurses not handling cytostatics (dic: (2.1 +/- 0.5)/1000 cells, ace: (9.9 +/- 1.1)/1000 cells). The frequency of chromatid breaks and SCE is not significantly different between these groups (p greater than 0.05).
Oestreicher
U
U
Institute for Radiation Hygiene of the Federal Health Office, Neuherberg, F.R.G.
Stephan
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G
Glatzel
M
M
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002875:Chromosomes / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009726:Nurses; D016273:Occupational Exposure; D010564:Personnel, Hospital; D010595:Pharmacists; D011482:Protective Devices; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents