Increased 6-hydroxycortisol excretion in pregnant women: implication of drug-metabolizing enzyme induction.
The effect of pregnancy on hepatic drug-metabolizing enzyme activity was investigated in nine healthy pregnant women using the ratio of 6-hydroxycortisol (6-OHF), to total 17-hydroxycorticosteroid (17-OHCS) in 24-hour urine as an index of the hepatic monooxygenase activity. The values of 6-OHF and the ratio (713 +/- 250 micrograms/d and 0.323 +/- 0.242; mean +/- SD) before delivery were significantly higher than they were during early puerperium (395 +/- 145 micrograms/d and 0.114 +/- 0.055) and approximately three months after delivery (237 +/- 67 micrograms/d and 0.066 +/- 0.034). Although the values three months after delivery were comparable to those found in the nonpregnant group (n = 10; 228 +/- 48 micrograms/d and 0.081 +/- 0.031), 6-OHF values one week after delivery were significantly higher than those observed in the control group. These observations suggest that drug-metabolizing enzyme induction may occur during pregnancy.
Ohkita
C
C
Department of Hospital Pharmacy, Tenri Hospital, Japan.
Goto
M
M
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000293:Adolescent; D000328:Adult; D004721:Endoplasmic Reticulum / Q000201:enzymology; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008099:Liver / Q000166:cytology / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D011247:Pregnancy / Q000652:urine*
D015065:17-Hydroxycorticosteroids; C001380:6 beta-hydroxycortisol; D006899:Mixed Function Oxygenases; D006854:Hydrocortisone