Ivermectin and coagulation: an in vitro study.
The prothrombin time, partial thromboplastin time with kaolin, and thrombin clotting time of plasma derived from healthy human volunteers were unaltered after in vitro addition of therapeutic concentrations (20-90 ng ml-1) of ivermectin. No difference in these coagulation tests, relative to untreated controls, was observed after 12 hours' incubation with the drug.
Hay
J
J
School of Pharmacy, Leicester Polytechnic.
Arnott
M A
MA
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007559:Ivermectin / Q000494:pharmacology*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013918:Thrombin Time; D013997:Time Factors
D007559:Ivermectin