[Pharmacological and clinical profile of tiaprofenic acid].
Tiaprofenic acid is a new generation anti-inflammatory drug synthesized to be a valid alternative to both cortisone preparations and other NSADs since it is less toxic yet equally effective. Its anti-inflammatory, analgesic, antipyretic activity is due to a particular interference mechanism active in the early phases of the inflammatory process (PG synthesis inhibition, stabilization of lysosomal membranes). Thanks to its good trophism toward tissues in the otolaryngological area and its tolerability this drug would appear particularly suited for the treatment of inflammatory E.N.T. pathologies.
Coppi
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Centro Ricerche, Poli Industria Chimica SpA MI.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D011298:Feprazone / Q000627:therapeutic use; D005480:Flurbiprofen / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy; D011422:Propionates / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013449:Sulfonamides / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D013449:Sulfonamides; C021270:tiaprofenic acid; D005480:Flurbiprofen; D011298:Feprazone; C012655:nimesulide
Profilo farmacologico e clinico dell'acido tiaprofenico.