Anti-idiotypic antibodies directed against anti-HBs among the patients with chronic hepatitis B.
Anti-idiotypic antibodies (anti-Id) against anti-HBs were found in the sera of patients with chronic hepatitis type B. Anti-idiotypic antibodies were detected by an enzyme-linked immunosorbent assay using horseradish peroxidase conjugated mouse monoclonal anti-HBs. Ten of 72 HBsAg positive sera contained anti-Id (13.9%). The prevalence of anti-Id did not appear to correlate with HBeAg/anti-HBe system. However, HB virus specific DNA polymerase activity was significantly higher in anti-Id positive sera. In the sera obtained from the patients treated with predonisolone before, anti-Id positive rate was higher than that in the patients without a history of predonisolone therapy. These results suggest that anti-Id may be related to the immunoregulatory mechanism of HB virus replication.
Kobayashi
K
K
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Suzuki
H
H
Ueno
Y
Y
Nagatomi
R
R
Kanno
A
A
Otsuki
M
M
Toyota
T
T
D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D002353:Carrier State / Q000276:immunology / Q000382:microbiology; D006509:Hepatitis B / Q000276:immunology* / Q000382:microbiology; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000502:physiology; D006521:Hepatitis, Chronic / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D014779:Virus Replication
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens