title: Expression of the thymus leukemia antigen in mouse intestinal epithelium.
abstract: The Qa and Tla regions of the mouse major histocompatibility complex contain a series of genes encoding proteins with structural similarity to the class I transplantation antigens of the same complex. In contrast to the genes encoding the transplantation antigens, the Qa and Tla genes show very little polymorphism. Function(s) of the proteins encoded by the Qa and Tla loci remain an enigma. Recently, the protein products of the Qa and Tla loci, often referred to as class Ib major histocompatibility complex molecules, have been proposed to present antigen to gamma delta T cells. In mice, gamma delta T cells have been found concentrated in several epithelial barriers and in the skin; yet, expression of serologically detectable Tla antigens is believed restricted to thymocytes, activated T lymphocytes, and some T-cell leukemias. Here we report that luminal epithelial cells of the mouse small intestine express the thymus leukemia antigen (TLA). We also find that, unlike T cells in Peyer's patches, a significant fraction of intestinal epithelial lymphocytes also express TLA. RNA prepared from intestinal cells contains transcripts of the T18d gene, which encodes TLA. These data extend the known expression profile of TLA molecules to mature lymphocytes and to nonhematopoietic cells. These data also demonstrate the specific expression of TLA on antigen-presenting cells in a site enriched for T cells that express gamma delta T-cell antigen receptor.
authors: Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine 90024.
authors: R
authors: R
authors: Hershberg
authors: P
authors: P
authors: Eghtesady
authors: B
authors: B
authors: Sydora
authors: K
authors: K
authors: Brorson
authors: H
authors: H
authors: Cheroutre
authors: R
authors: R
authors: Modlin
authors: M
authors: M
authors: Kronenberg
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000235:genetics*; D004848:Epithelium / Q000276:immunology; D005434:Flow Cytometry; D015870:Gene Expression; D007421:Intestine, Small / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010641:Phenotype; D016133:Polymerase Chain Reaction; D013950:Thymus Gland / Q000276:immunology*; D014158:Transcription, Genetic
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens