[Sensitivity and specificity of the determination of urinary catecholamines and their acid metabolites in the diagnosis of neuroblastoma in children].
A retrospective comparison of urinary excretion of norepinephrine, epinephrine, dopamine and/or their acidic metabolites, HVA and VMA, in 36 children with neuroblastoma versus 360 hospitalized children without neuroblastoma showed a sensibility of 72% and a specificity of 98% for HVA and 80% and 97% for VMA respectively. Consequently, the sensibilities and specificities of these 2 determinations confirm their useful purpose for the biochemical diagnosis of neuroblastoma in preference to the determinations of norepinephrine, epinephrine and dopamine.
Horsmans
Y
Y
Laboratoire de pharmacothérapie, université catholique de Louvain, Bruxelles, Belgique.
Desager
J P
JP
Harvengt
C
C
D000293:Adolescent; D002395:Catecholamines / Q000378:metabolism / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004298:Dopamine / Q000378:metabolism / Q000652:urine; D004837:Epinephrine / Q000378:metabolism / Q000652:urine; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D009638:Norepinephrine / Q000378:metabolism / Q000652:urine; D012189:Retrospective Studies; D014642:Vanilmandelic Acid / Q000652:urine
D002395:Catecholamines; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine
Sensibilité et spécificité du dosage des catécholamines urinaires et de leurs métabolites acides dans le diagnostic du neuroblastome chez l'enfant.