Presymptomatic exclusion of myotonic dystrophy in a one-generation pedigree of half-siblings.
An unusual one-generation family with myotonic dystrophy is presented, in which genetic counseling was successfully carried out. The probability of an informative result, before marker typing, is analytically derived and amounts to at least 40%.
Ott
J
J
Department of Psychiatry, Columbia University, New York, NY.
Caesar
J
J
Mächler
M
M
Schinzel
A
A
Schmid
W
W
D005260:Female; D005817:Genetic Counseling; D005819:Genetic Markers; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009223:Myotonic Dystrophy / Q000175:diagnosis* / Q000235:genetics; D010375:Pedigree
D005819:Genetic Markers