Hereditary tyrosinemia of chronic course without rickets and renal tubular dysfunction.
Three patients with hereditary tyrosinemia type 1, two brothers and one girl, studied at the age of 5, 12 and 15 years, respectively, had neither generalized hyperaminoaciduria, glucosuria nor clinical symptoms of rickets. Untreated the elder brother had only slightly elevated plasma tyrosine level (141 mumol/l, normal less than 80), and low excretion of p-hydroxyphenyllactate. He presented with pronounced thrombocytopenia (3 X 10(9)/l). At 13 years of age he contracted hepatocellular carcinoma. The younger brother presented with serum tyrosine of 318 mumol/l and thrombocyte count 48 X 10(9)/l. Succinylacetone in urine was elevated in both, 30 and 79 mumol/mmol creatinine, respectively. The female patient was investigated for hepatomegaly in infancy, atypical tyrosinemia being considered, but afterwards developed normally without diet or any other treatment until she contracted hepatoma at the age of 15 years. Her plasma tyrosine level was 600-700 mumol/l, and she excreted large amounts of p-hydroxyphenyllactate. Succinylacetone in urine was low but elevated (8 mumol/mmol creatinine). The fumarylacetoacetase activity in fibroblasts from the brothers and in lymphocytes from the girl was less than 5% and 10% of control levels, respectively. In conclusion, the chronic form of hereditary tyrosinemia may occur without evidence of renal tubular dysfunction.
Søvik
O
O
Department of Paediatrics, University of Bergen, Norway.
Kvittingen
E A
EA
Steen-Johnsen
J
J
Halvorsen
S
S
D000293:Adolescent; D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism*; D000596:Amino Acids / Q000652:urine; D002648:Child; D002675:Child, Preschool; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications; D005260:Female; D006418:Heme / Q000037:antagonists & inhibitors; D006537:Heptanoates / Q000652:urine; D006801:Humans; D006867:Hydrolases / Q000032:analysis; D008297:Male; D000623:Porphobilinogen Synthase / Q000032:analysis; D013921:Thrombocytopenia / Q000150:complications; D014443:Tyrosine / Q000097:blood*
D000596:Amino Acids; D006537:Heptanoates; D014443:Tyrosine; D006418:Heme; C020804:succinylacetone; D006867:Hydrolases; C020156:fumarylacetoacetase; D000623:Porphobilinogen Synthase