Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries.
The effects of endothelin on the vascular renin-angiotensin system were examined in isolated perfused rat mesenteric arteries by measuring vascular renin activity and angiotensin II released into the perfusate. Infusion of endothelin (10(-9)M and 10(-11)M) increased the vascular renin activity and angiotensin II release. Pretreatment with nicardipine (10(-6)M), a calcium channel blocker, significantly suppressed these effects of endothelin. These results suggest that endothelin activates the vascular renin-angiotensin system via intracellular calcium metabolism. Vascular angiotensin II produced by endothelin may modulate the local effect of endothelin on the resistance vessels.
Rakugi
H
H
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Tabuchi
Y
Y
Nakamaru
M
M
Nagano
M
M
Higashimori
K
K
Mikami
H
H
Ogihara
T
T
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D016232:Endothelins / Q000378:metabolism*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D009529:Nicardipine / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000187:drug effects*
D016232:Endothelins; D000804:Angiotensin II; D009529:Nicardipine; D012083:Renin