title: Distribution of airway narrowing during hyperpnea-induced bronchoconstriction in guinea pigs.
abstract: Increasing minute ventilation of dry gas shifts the principal burden of respiratory heat and water losses from more proximal airway to airways farther into the lung. If these local thermal transfers determine the local stimulus for bronchoconstriction, then increasing minute ventilation of dry gas might also extend the zone of airway narrowing farther into the lung during hyperpnea-induced bronchoconstriction (HIB). We tested this hypothesis by comparing tantalum bronchograms in tracheostomized guinea pigs before and during bronchoconstriction induced by dry gas hyperpnea, intravenous methacholine, and intravenous capsaicin. In eight animals subjected to 5 min of dry gas isocapnic hyperpnea [tidal volume (VT) = 2-5 ml, 150 breaths/min], there was little change in the diameter of the trachea or the main stem bronchi up to 0.75 cm past the main carina (zone 1). In contrast, bronchi from 0.75 to 1.50 cm past the main carina (zone 2) narrowed progressively at all minute ventilations greater than or equal to 300 ml/min (VT = 2 ml). More distal bronchi (1.50-3.10 cm past the main carina; zone 3) did not narrow significantly until minute ventilation was raised to 450 ml/min (VT = 3 ml). The estimated VT during hyperpnea needed to elicit a 50% reduction in airway diameter was significantly higher in zone 3 bronchi [4.3 +/- 0.8 (SD) ml] than in zone 2 bronchi (3.5 +/- 1.1 ml, P less than 0.012).(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Medicine, University of Chicago, Illinois 60637.
authors: D W
authors: DW
authors: Ray
authors: S
authors: S
authors: Eappen
authors: C
authors: C
authors: Hernandez
authors: M
authors: M
authors: Jackson
authors: L E
authors: LE
authors: Alger
authors: A R
authors: AR
authors: Leff
authors: J
authors: J
authors: Solway
mesh_terms: D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology*; D001995:Bronchography; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D013635:Tantalum; D014132:Trachea / Q000502:physiology
chemical_list: D008688:Methacholine Compounds; D013635:Tantalum; D002211:Capsaicin