[The radiation modifying properties of carnosine].
The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated. Carnosine (50-200 mg/kg/day) administered per os during a period of 20 days before irradiation (5.0 Gy) increased the survival rate by 45-65%, whereas the administration of carnosine within 30 days after irradiation (5.5 Gy) produced an insignificant protective effect and caused inhibition of the postirradiation histamine accumulation in the spleen.
Severin
S E
SE
Boldyrev
A A
AA
Stvolinskiĭ
S L
SL
Bordiukov
M M
MM
Goncharenko
E N
EN
Deev
L I
LI
Malinina
I E
IE
Kudriashov
Iu B
IuB
D000284:Administration, Oral; D000818:Animals; D002336:Carnosine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000517:prevention & control; D014916:Whole-Body Irradiation
D002336:Carnosine
O radiomodifitsiruiushchikh svoĭstvakh karnozina.