Aminophylline activation of adrenaline mediated transmembrane K transfer in hyperkalemic dogs.
Ureter ligated control dogs that are K loaded by infusion with 2 mEq KCl/kg.h until prelethal electrocardiographic changes of hyperkalemic cardiotoxicity appear, transfer somewhat more than half the K load to intracellular fluid. The proportion is not significantly changed by adrenalectomy, but increased by treatment with aminophylline; the treatment has no effect on K transfer in adrenalectomized animals. Insulin is not involved; in dogs with adrenalectomy and pancreatectomy treatment with pharmacological dosages of adrenaline (Abbot), beta agonist activity is as effective as that with aminophylline. We conclude that aminophylline improves K transfer, by investifying beta agonist activity of endogenous adrenaline; it is known that increased beta agonist activity enhances beta receptor mediated K transfer in K loaded ureter ligated, intact and adrenalectomized dogs.
Hiatt
N
N
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Hiatt
J
J
D000315:Adrenalectomy; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D006947:Hyperkalemia / Q000378:metabolism*; D008026:Ligation; D008297:Male; D010180:Pancreatectomy; D011188:Potassium / Q000378:metabolism*; D014513:Ureter / Q000601:surgery
D000628:Aminophylline; D011188:Potassium; D004837:Epinephrine