Diurnal variation in total plasma tryptophan in controls and in depression.
Circadian rhythms of total tryptophan were investigated by assays of hourly blood samples over 25 h. The study population consisted of four endogenously depressed patients investigated in the absence of any treatment and six healthy controls. The abnormalities detected by statistical analyses in untreated depression consisted mainly of amplitude reduction; the phase positions of the depressed patients were similar to those of the controls.
Candito
M
M
Laboratoire de Biochimie, Service du Docteur Chambon, Hôpital Pasteur, Nice, France.
Souêtre
E
E
Iordache
A
A
Pringuey
D
D
Ardisson
J L
JL
Chambon
P
P
Darcourt
G
G
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D002940:Circadian Rhythm / Q000502:physiology*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014364:Tryptophan / Q000097:blood*
D014364:Tryptophan