[Human alfa-2b in rabbit's eyes].
The toxicity of human interferon alpha 2b in rabbit's vitreous and conjonctiva is studied through electroretinography, echography, angiography and histological examination. Interferon was injected in increasing doses 150,000 UI, 500,000 UI and 1,000,000 UI. The results from examinations in the rabbits are presented and the conclusion is drawn, that good tolerance is achieved, even at higher doses.
Prata
L
L
Instituto de Oftalmologia, Universidade de Lisboa, Portugal.
Folgado
A
A
Maia-Seco
J
J
Carvalho
A
A
Mendonça
E
E
Mâncio-Santos
A
A
D000818:Animals; D003228:Conjunctiva / Q000187:drug effects*; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D007267:Injections; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000633:toxicity*; D011994:Recombinant Proteins; D013997:Time Factors; D014822:Vitreous Body / Q000187:drug effects*
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Interféron alfa 2b humain dans les yeux du lapin.