Suppression of ethanol intake in ethanol-preferring rats by 1,4-butanediol.
The oral administration of 1,4-butanediol (1,4-BD) at doses ranging from 100 to 300 mg/kg, twice daily, produced a dose-dependent reduction (40 to 85%) in the voluntary ethanol intake in rats selectively bred for high preference for ethanol. Treatment with 1,4-BD did not reduce total fluid intake. Repeated 1,4-BD administration (300 mg/kg twice daily for 7 days) suppressed ethanol intake almost completely. After suspension of 1,4-BD treatment, the inhibitory effect on ethanol intake remained significantly low for 2 days. 1,4-BD failed to inhibit aldehyde dehydrogenase to a concentration of 10 mM in rat liver homogenate.
Colombo
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Department of Neurosciences, University of Cagliari, Italy.
Mosca
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Gessa
G L
GL
Fadda
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F
D000428:Alcohol Drinking; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors; D000818:Animals; D002072:Butylene Glycols / Q000494:pharmacology*; D003864:Depression, Chemical; D051381:Rats; D011919:Rats, Inbred Strains
D002072:Butylene Glycols; C039681:1,4-butanediol; D000444:Aldehyde Dehydrogenase