title: [Changes in systemic and intracardiac hemodynamics during bicycle ergometry in patients with fibrillation arrhythmia treated with allapinin before and after sinus rhythm recovery].
abstract: In atrial fibrillation, allapinine was shown to enhance rhythm by 7% and to increase cardiac output (p less than 0.05), as well as to slightly lower mean blood pressure and peripheral vascular resistance at rest. With exercise, both in atrial fibrillation, and sinus rhythm, there was a decrease in end-diastolic and end-systolic volumes of the left ventricle (p less than 0.05), a slight drop in ventricular ejection, that was statistically significant only with sinus rhythm (p less than 0.05). Physical exercise was not followed by an apparent additional aggravation of myocardial contractility, which makes allapinine preferable for long-term application to preserve sinus rhythm in patients without evident signs of heart failure.
authors: A S
authors: AS
authors: Smetnev
authors: M M
authors: MM
authors: Kadyrova
authors: Iu S
authors: IuS
authors: Sobol'
authors: S F
authors: SF
authors: Sokolov
authors: F T
authors: FT
authors: Ageev
authors: A N
authors: AN
authors: Rogoza
authors: A Sh
authors: ASh
authors: Gorshkov
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004452:Echocardiography; D005080:Exercise Test; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000889:Anti-Arrhythmia Agents; C051402:allapinin; D000157:Aconitine
vernacular_title: Izmenenie sistemnoĭ i vnutriserdechnoĭ gemodinamiki vo vremia veloérgometrii u bol'nykh s mertsiatel'noĭ aritmieĭ na fone priema allapinina do i posle vosstanovleniia sinusovogo ritma.