[Immediate and long-term results of the use of plasmapheresis in obliterating atherosclerosis of the vessels of the lower limbs].
Plasmapheresis was applied to treat 67 patients with lower extremity vessel atherosclerosis obliterans. A total of 92 therapy courses were performed, which involved 250 sessions of plasmapheresis (205 with a PF-0.5 apparatus and 45 with plastic bags and centrifuge). During the course, an average of 160% volume of circulating plasma were removed to be replaced with crystalloids and dextrans. A positive effect shown by a 6.9-fold increase in the distance covered by patients who experienced no pains and by resting pain relief was achieved in 93.8% with Stage II circulatory failure and 75% with Stage III, regardless of the severity of vascular lesions. It was shown that it was necessary to make a "programmed" plasmapheresis when the patient received 2 plasmapheresis courses a year. The mechanism of a positive effect of plasmapheresis remains unclear. A significant plasmapheresis-induced decrease was observed in the concentration of "acute phase proteins" (plasma fibrinogen and globulins), which plays the leading role in improving blood rheology, which seems to affect clinical outcomes.
Kliachkin
M L
ML
Marchenko
V B
VB
D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000097:blood / Q000628:therapy*; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D012712:Serum Globulins / Q000032:analysis; D013997:Time Factors
D012712:Serum Globulins; D005340:Fibrinogen
Blizhaĭshie i otdalennye rezul'taty primeneniia plazmafereza pri obliteriruiushchem ateroskleroze sosudov nizhnikh konechnosteĭ.