title: Susceptibility of inbred mice to Leishmania major infection: genetic analysis of macrophage activation and innate resistance to disease in individual progeny of P/J (susceptible) and C3H/HeN (resistant) mice.
abstract: We tested the possibility that two phenotypic traits, defective activation of macrophage antileishmanial activities and susceptibility to infection with Leishmania major, were controlled by the same gene. We used P/J (susceptible) and C3H/HeN (resistant) mice to breed F1, backcross (Bx), and F2 mice that were tested individually for both traits, each of which is known to be controlled by a single autosomal gene. We found no correlation between the macrophage defect and cutaneous disease. There was a correlation between development of systemic disease and defective macrophage activation in Bx mice; this correlation, however, was not confirmed in the F2 population.
authors: Department of Cellular Immunology, Walter Reed Army Institute of Research, Washington, D.C. 20307.
authors: A H
authors: AH
authors: Fortier
authors: A
authors: A
authors: Tong
authors: C A
authors: CA
authors: Nacy
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D007895:Leishmania tropica; D007896:Leishmaniasis / Q000235:genetics / Q000276:immunology*; D008222:Lymphokines / Q000494:pharmacology; D008262:Macrophage Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H
chemical_list: D008222:Lymphokines