Changes in lipid profiles of brain of albino rats following envenomation.
Effect of high doses of cobra venom (150 micrograms/120 +/- 20 g body weight) and viper venom (300 micrograms/120 +/- 20 g body weight) on total lipid, triglyceride, phospholipid, cholesterol, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of brain of albino rats was studied. Total lipid (TL) triglyceride (TG) and phospholipid (PL) are decreased in both viper and cobra venom treated groups while cholesterol (C), and LDL-C are increased in both the groups in relation to controlled ones. HDL-C content was almost unaltered. Decrease in triglyceride and phospholipid may be due to effect of lipases and phospholipases whereas increased cholesterol and LDL-C may be attributed to lysis of cell membrane.
Sahu
J K
JK
Department of Biochemistry, Burdwan Medical College, India.
Majumdar
G
G
Maity
C R
CR
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004546:Elapid Venoms / Q000494:pharmacology*; D005260:Female; D008055:Lipids / Q000032:analysis*; D008297:Male; D008563:Membrane Lipids / Q000032:analysis; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D014757:Viper Venoms / Q000494:pharmacology*
D004546:Elapid Venoms; D008055:Lipids; D008563:Membrane Lipids; D014757:Viper Venoms; D010741:Phospholipases A