Platelet monoamine oxidase B activity in parkinsonian patients.
Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.
Bonuccelli
U
U
Institute of Clinical Neurology, University of Pisa, Italy.
Piccini
P
P
Del Dotto
P
P
Pacifici
G M
GM
Corsini
G U
GU
Muratorio
A
A
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010300:Parkinson Disease / Q000201:enzymology*; D012737:Sex Factors
D007527:Isoenzymes; D008995:Monoamine Oxidase