title: Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity.
abstract: Autoantibodies that reacted with cell bodies and axon terminals of gamma-aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff-man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L-glutamic acid decarboxylase. While L-glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.
authors: Department of Neurology, University of California, Davis 95616.
authors: F
authors: F
authors: Gorin
authors: B
authors: B
authors: Baldwin
authors: R
authors: R
authors: Tait
authors: R
authors: R
authors: Pathak
authors: M
authors: M
authors: Seyal
authors: E
authors: E
authors: Mugnaini
mesh_terms: D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D002415:Cats; D002999:Clone Cells; D005188:False Negative Reactions; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013577:Syndrome
chemical_list: D001323:Autoantibodies; D005968:Glutamate Decarboxylase