title: Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus.
abstract: Bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices. A concentration of 1 microM muscarine did not affect the evoked population spike or excitatory postsynaptic potential (EPSP), but facilitated the induction of LTP. In contrast, a concentration of 10 microM muscarine depressed both the population spike and EPSP, but had no effect on LTP induction. The M1 muscarinic receptor antagonist pirenzepine (1 microM) blocked the muscarine-induced facilitation of LTP, but had no effect on the depression of evoked responses. These data suggest that activation of M1 receptors can facilitate the induction of LTP.
authors: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
authors: E C
authors: EC
authors: Burgard
authors: J M
authors: JM
authors: Sarvey
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D009116:Muscarine / Q000494:pharmacology*; D010890:Pirenzepine / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*
chemical_list: D011976:Receptors, Muscarinic; D010890:Pirenzepine; D009116:Muscarine