Reduction of toxicity and increase of antitumor effect of adriamycin by N-acyl dehydroalanines, a new family of free radical scavengers.
Buc-Calderon
P
P
Unité de Biochimie Cancérologique et Toxicologie, Univ. Catholique de Louvain, Belgium.
Praet
M
M
Ruysschaert
J M
JM
Roberfroid
M
M
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004317:Doxorubicin / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D016166:Free Radical Scavengers; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy / Q000503:physiopathology; D007942:Leukemia, Experimental / Q000188:drug therapy; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000187:drug effects; D010084:Oxidation-Reduction; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
D016166:Free Radical Scavengers; D008563:Membrane Lipids; D011837:Radiation-Protective Agents; C053274:AD 20; D004317:Doxorubicin; D000409:Alanine