Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons.
The SJMNs made accessible in the in vitro juxtamedullary nephron preparation possess an arteriolar renin and Ang II distribution similar to other nephron populations; renin-rich cells prevail in the JAA. Physiological studies have documented that exogenous Ang II constricts both pre- and postglomerular vessels of SJMNs. However, Ang II predominantly increases afferent resistance along the JAA. A functional interaction between Ang II and prostaglandins is likely to occur in preglomerular vessels and deserves further assessment. An additive, functional interaction was demonstrated between Ang II and autoregulation in afferent arterioles. Calcium channel blockers interfere with Ang II-induced constriction only in preglomerular vessels of SJMNs.
Casellas
D
D
Groupe Rein et Hypertension, Montpellier, France.
Carmines
P K
PK
Dupont
M
M
Redon
P
P
Moore
L C
LC
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D009399:Nephrons / Q000098:blood supply / Q000737:chemistry*; D012083:Renin / Q000378:metabolism*
D002121:Calcium Channel Blockers; D000804:Angiotensin II; D012083:Renin