Pharmacokinetics and toxic effects of nifedipine in massive overdose.
A 57-year-old man took 30 x 20 mg nifedipine retarded release tablets. He developed hypotension, tachycardia and flushing, but remained in sinus rhythm. The concentration of nifedipine 10 h after overdose was 604 micrograms 1-1, and of the M-I metabolite 110 micrograms 1-1. Log concentration time curves were linear from 10-72 h for nifedipine, with a half-life of 7.5 h; and for M-I with a half-life of 8.2 h. On this evidence, oral absorption of nifedipine retarded release is complete by 10 h. There was no evidence of saturation of nifedipine or M-I metabolism, even at concentrations ten times above the therapeutic concentration.
Ferner
R E
RE
Freeman Hospital, Newcastle-upon-Tyne, UK.
Monkman
S
S
Riley
J
J
Cholerton
S
S
Idle
J R
JR
Bateman
D N
DN
D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000493:pharmacokinetics / Q000506:poisoning*
D009543:Nifedipine