[Early detection of successful reperfusion by analysis of serum myoglobin in patients with acute myocardial infarction].
We examined the changes of serum myoglobin (Mb) levels after reperfusion therapy (PTCR, PTCA) in 24 patients with acute myocardial infarction by latex agglutination turbidimetry. In the cases of 13 patients successfully reperfused, significantly higher Mb levels was observed and they disappeared rapidly from blood after the therapy. On the other hand, serum Mb levels disappeared slowly in the cases of patients unsuccessfully reperfused. The disappearance rate of Mb (23.4 +/- 6.7%) in successful reperfused patients was higher than that in unsuccessful reperfusion (5.3 +/- 6.8%) (p less than 0.001), the cut-off value of serum Mb levels in the decision regarding success or failure of reperfusion was set at 17% of disappearance rate, the predictive values for successful and unsuccessful reperfusion were 92% and 91% respectively. The maximum peak time of CK, CK-MB activities and Mb levels after onset of chest pain were also observed. Only the maximum peak time of CK-MB was significantly fasten than others in the cases of patients sera with successful reperfusion (p less than 0.05). We conclude that the measurement of serum Mb levels was useful and suitable for rapid judging on success or failure of reperfusion therapy by use of the disappearance rate of it.
Kawata
Y
Y
Department of Clinical Laboratory, National Cardiovascular Center, Suita.
Moriwaki
K
K
Yoneda
K
K
Fujita
S
S
Katayama
Y
Y
Matsuyama
T
T
D005069:Evaluation Studies as Topic; D006801:Humans; D007841:Latex Fixation Tests; D009203:Myocardial Infarction / Q000628:therapy*; D015425:Myocardial Reperfusion; D009211:Myoglobin / Q000097:blood*
D009211:Myoglobin