Structure of class-I MHC molecules: HLA-B27 and disease.
In this introductory article, the structure and function of HLA class-I molecules is discussed. The differences between HLA-B27 and the other class-I molecules are described. It is suggested that HLA-B27 contributes to autoimmune phenomena, but little is known about the actual autoimmune mechanisms that cause the B27-associated disease.
Parham
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Department of Cell Biology, Stanford University, CA.
D000595:Amino Acid Sequence; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity; D015796:HLA-B27 Antigen / Q000737:chemistry* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D015796:HLA-B27 Antigen; D015395:Histocompatibility Antigens Class I