[A giant struma histologically confirmed as a medullary carcinoma with multiple systemic bone metastasis].
Reported is the case of a 46 year old woman with no significant family medical history, who presented a neck tumor that she had had for about ten years. This large tumor was noted on her admittance to hospital due to a bone fracture. She subsequently underwent a resection of this giant neck tumor. A histologic examination of the specimen revealed a medullary carcinoma of the follicular variety. Silver impregnation by the Grimelius method caused a positive reaction, and an electron-microscopic examination revealed round, electron-dense, endocrine granules about 195 nm in diameter, Immunohistochemically, the carcinoembryonic antigen (CEA) and the presence of calcitonin proved the cells to be cancerous.
Saito
M
M
Dept. of Second Surgery, Toyama Med. and Pharmaceutical Univ.
Karaki
Y
Y
Kasagi
T
T
Kushibuchi
T
T
Tajika
S
S
Tazawa
K
K
Fujimaki
M
M
D001859:Bone Neoplasms / Q000556:secondary*; D002116:Calcitonin / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure
D002272:Carcinoembryonic Antigen; D002116:Calcitonin