title: Prolactin and propranolol prevent the suckling-induced inhibition of lactation in rabbits.
abstract: The normal once-a-day frequency of suckling in the rabbit was increased on day 31 (late lactation) by the addition of two extra sucklings (8 and 16 hr after) the daily suckling. In confirmation of previous data, two additional sucklings significantly decreased milk yield acutely on day 31 in comparison with the average 4-day milk yield before and after day 31. The decrease in milk secretion after the two additional sucklings was prevented by a single injection of 3 mg prolactin (given 24 hr before the two extra sucklings) and/or by injections of the beta-adrenergic-blocking drug, propranolol (100 micrograms/kg b. wt. given 30 min before each additional suckling). Since prolactin secretion is decreased in these species and the mammary gland is less responsive to the hormone during late lactation, the present results suggest that in addition to these factors, suckling-induced activation of sympathetic influences may contribute to the decline in milk production at this stage of lactation. Taken together, these results suggest that suckling may regulate lactation in the rabbit through antagonistic mechanisms at different stages of lactation.
authors: Departamento de Fisiología, Universidad Nacional Autónoma de México, D.F.
authors: F
authors: F
authors: Mena
authors: C
authors: C
authors: Clapp
authors: D
authors: D
authors: Aguayo
authors: G
authors: G
authors: Martínez de la Escalera
mesh_terms: D000818:Animals; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000294:innervation; D008893:Milk Ejection / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects*; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D013391:Sucking Behavior / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D011388:Prolactin; D011433:Propranolol