title: [Fetal complete heart block with myocarditis and maternal SS-A-/AA-B/antibodies].
abstract: We report on a newborn with fetal acquired heart block (CHB). CHB is a rare, irreversible defect, commonly occurring in conjunction with myocarditis in the neonatal lupus syndrome. Development of CHB is strongly associated with maternal anti-SS-A(Ro)/SS-B(La) antibodies. Intrauterine therapy of CHB is not possible. Concomitant myocarditis, however, can be treated effectively with dexamethasone. Mothers with an elevated risk of fetal CHB can be identified by their history (underlying systemic connective tissue disease, previous pregnancies with CHB), an immunogenetic predisposition (HLA-DR3) and analysis of the SS-A/SS-B antibody pattern. In these pregnancies prevention of CHB with plasmapheresis plus dexamethasone during pregnancy may be possible.
authors: Medizinische Universitätsklinik, Abteilung Rheumatologie und Klinische Immunologie, Freiburg.
authors: B
authors: B
authors: Lang
authors: C
authors: C
authors: Wilhelm
authors: P
authors: P
authors: Gildein
authors: P
authors: P
authors: Vaith
authors: H
authors: H
authors: Schillinger
authors: H H
authors: HH
authors: Peter
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000302:isolation & purification*; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control; D006327:Heart Block / Q000151:congenital* / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009205:Myocarditis / Q000151:congenital* / Q000209:etiology; D010956:Plasmapheresis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies
vernacular_title: Fetaler kompletter Herzblock und Myokarditis bei mütterlichen SS-A-/SS-B-Antikörpern.