[Studies on toxicokinetics of 14C-fenvalerate in animals].
Using tracer technique of 14C isotope, toxicokinetics of fenvalerate was studied in rats and mice. The results strongly suggested the existence of distinct differences between species in mammals in the metabolism of 14C-fenvalerate. The absorption and elimination of 14C-fenvalerate in the blood of mice following single intragastric administration was faster than that of the rats. The plasma and brain of animal have greater affinity for 14C-fenvalerate. The absorption of fenvalerate was faster and the biological half-time was longer in brain. 14C-fenvalerate and its metabolites were mainly eliminated through urine and fenvalerate can partially be stored in the skin and the hair of animal.
Gong
Z C
ZC
Department of Occupational Health, Shanghai Medical University.
D000818:Animals; D002250:Carbon Radioisotopes; D007306:Insecticides; D008297:Male; D051379:Mice; D009570:Nitriles; D011722:Pyrethrins / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D013045:Species Specificity
D002250:Carbon Radioisotopes; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017690:fenvalerate