Tolerance to ethanol-induced hypothermia in adult rats following postnatal ethanol exposure.
Rat pups of both genders were treated during the entire postnatal brain growth spurt (postnatal days 1-20) with ethanol (EE) utilizing an intragastric intubation technique. Two other groups of pups included isocaloric vehicle and handled control pups. Beginning on postnatal day 43 (TD1), and every seventh day subsequently (TD's 2, 3 and 4), the rats received an intraperitoneal dose of 2.2 g/kg ethanol. Their body temperatures were recorded at 0, 30, 60 and 90 minutes postinjection by use of a rectal probe. On the six days between measurements of ethanol-induced hypothermia, all rats were administered a daily dose of ethanol by intragastric intubation. Body growth of male and female pups was inhibited throughout the early treatment period. Body growth of adult females, but not males, was also depressed on TD's 1 and 2. Basal body temperature of EE male rats was selectively depressed at TD2, compared to the other groups. Although all groups showed tolerance to ethanol-induced hypothermia by TD2, there was a significant difference between males and females. Specifically, EE female rats showed a greater degree of tolerance when compared to EE males or control females.
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Center for Addiction Studies, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock 72205.
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Fletcher
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Serbus
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D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000431:Ethanol