title: Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.
abstract: Since epithelial downgrowth involves an actively proliferating intraocular tissue, it is possible that the antimetabolite 5-fluorouracil may inhibit it. We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil. On cessation of the injections, the retrocorneal membrane grew rapidly to involve the entire posterior cornea. The eye eventually became blind and painful and was enucleated. The use of 5-fluorouracil given in the usual manner appears to have been a failure.
authors: Department of Ophthalmology, University of California, San Diego.
authors: M E
authors: ME
authors: Loane
authors: R N
authors: RN
authors: Weinreb
mesh_terms: D000867:Anterior Chamber / Q000473:pathology; D002387:Cataract Extraction / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects; D003316:Corneal Diseases / Q000150:complications / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D015353:Eye Enucleation; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D014130:Trabeculectomy
chemical_list: D005472:Fluorouracil