Theoretical isoelectric points and electric charges of mutated human hemoglobin subunits.
Isoelectric point values have been determined from a theoretical standpoint for alpha, beta, gamma and delta human abnormal subunits bearing elimination or addition of 1-2 different aminoacids with acid-base residues. The charge distribution, in relation to pH values, of the four types of subunits are also reported. These values may be of interest both to predict the electrophoretic behaviour and to characterize human abnormal hemoglobins.
Ribeiro
J M
JM
Departamento de Bioquímica, C.S.I.C., Facultad de Medicina, Universidad Autónoma de Madrid, Spain.
Ruiz
A
A
Sillero
M A
MA
Sillero
A
A
D000595:Amino Acid Sequence; D004563:Electrochemistry; D005914:Globins / Q000737:chemistry; D006455:Hemoglobins, Abnormal / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007526:Isoelectric Point; D009154:Mutation
D006455:Hemoglobins, Abnormal; D005914:Globins