[Effect of beta-adrenergic blockade on cortisol secretion in insulin-induced hypoglycemia in animals with experimental diabetes mellitus].
An effect of the selective beta-adrenergic block with metoprolol and non-selective beta-adrenergic block with propranolol on the hypoglycaemia was investigated in 30 dogs of the control group and 30 dogs with alloxan diabetes. A significant increase in cortisol secretion was seen in the insulin-induced hypoglycaemia in both groups without beta-adrenergic block. It suggests an important role of cortisol in the normalization of glycaemia following an administration of the exogenous insulin. Beta-adrenergic block, especially with metoprolol, produces a significant increase in cortisol secretion confirming the report on direct effect of this beta-adrenolytic agent on cortisol secretion.
Szelachowska
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Kliniki Endokrynologii AM w Białymstoku.
Kinalska
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D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology*; D008790:Metoprolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D007328:Insulin; D011433:Propranolol; D008790:Metoprolol; D006854:Hydrocortisone
Wpływ blokady beta-adrenergicznej na wydzielanie kortyzolu w hipoglikemii poinsulinowej u zwierzat z cukrzyca doświadczalna.