title: Randomised comparative efficacy of clindamycin, metronidazole, and lincomycin, plus gentamicin in chronic suppurative otitis media.
abstract: Chronic suppurative otitis media is major health problem seen frequently in the ENT clinics in Nigeria and the outcome of most medical management in the past have been disappointing. A comparative randomised clinical trial involving combination therapies with systemic clindamycin, metronidazole, lincomycin, each with gentamicin, was conducted on a total of 14 patients. At the end of one week, and three-week, follow-up end points the clinical response with bacteriological cure were, for clindamycin and gentamicin 21%, metronidazole and gentamicin 33%, lincomycin and gentamicin 22%, and the control (aural toilet alone) 14%. However, when the clinical response was measured only by the ceasation of discharge, the outcome was more impressive. By this assessment the clinical response with clindamycin and gentamicin was 52% of the 140 patients, metronidazole and gentamicin 69%, lincomycin and gentamicin 47%, and the control 24%. The metronidazole and gentamicin regime was significantly more effective than the other regimes and it is suggested for use in prophylactic treatment of CSOM patients undergoing surgical procedures.
authors: Department of Medical Microbiology & Parasitology, College of Medicine, Lagos University Teaching Hospital, Nigeria.
authors: V O
authors: VO
authors: Rotimi
authors: D A
authors: DA
authors: Olabiyi
authors: T O
authors: TO
authors: Banjo
authors: P A
authors: PA
authors: Okeowo
mesh_terms: D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008034:Lincomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010035:Otitis Media, Suppurative / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D005839:Gentamicins; D008795:Metronidazole; D002981:Clindamycin; D008034:Lincomycin