Penetration of aminoglycosides into human peritoneal tissue.
Each of 30 patients underwent elective laparotomy following administration of a single intravenous dose of amikacin, netilmicin or tobramycin. Therapeutic concentrations of amikacin were achieved in peritoneal tissue in 10/10 patients. Only 13/20 samples from patients receiving the other two antibiotics showed antibacterial activity. Our data suggest that the penetrability of tobramycin (53%) and amikacin (39%) into the uninflamed peritoneal tissue is superior to that of netilmicin (16%).
Serour
F
F
Department of Surgery A, E. Wolfson Medical Center, Holon.
Dan
M
M
Gorea
A
A
Gilad
A
A
Krispin
M
M
Berger
S A
SA
D000583:Amikacin / Q000008:administration & dosage / Q000032:analysis*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009428:Netilmicin / Q000008:administration & dosage / Q000032:analysis*; D010537:Peritoneum; D011897:Random Allocation; D014031:Tobramycin / Q000008:administration & dosage / Q000032:analysis*
D009428:Netilmicin; D000583:Amikacin; D014031:Tobramycin