Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity.
Paraherquamide and six novel analogs were isolated from the fermentation of Penicillium charlesii (ATCC 20841). All seven natural products displayed potent antinematodal activity against Caenorhabditis elegans. None of the novel analogs were more potent than paraherquamide.
Ondeyka
J G
JG
Merck & Co., Inc., Rahway, New Jersey 07065-0900.
Goegelman
R T
RT
Schaeffer
J M
JM
Kelemen
L
L
Zitano
L
L
D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002107:Caenorhabditis / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003470:Culture Media; D005285:Fermentation; D007212:Indolizines / Q000302:isolation & purification* / Q000494:pharmacology; D010407:Penicillium / Q000378:metabolism*; D012988:Soil Microbiology; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology
D000871:Anthelmintics; D000969:Antinematodal Agents; D003470:Culture Media; D007212:Indolizines; D013141:Spiro Compounds; C063985:paraherquamide