Antibody targeted therapy in cancer: comparison of murine and clinical studies.
Antibody targeted therapy can be effective in animal models of cancer. Treatment has been less successful in man, though some responses are reported. Understanding the distribution of antibody in man and animals shows how toxicity may be minimized and patients selected for therapy on the basis of efficient antibody localization in the tumour.
Begent
R H
RH
Cancer Research Campaign Laboratories, Charing Cross and Westminster Medical School, London, U.K.
Pedley
R B
RB
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000276:immunology; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D009374:Neoplasms, Experimental / Q000276:immunology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes