[Elimination of viscoelastic substances from the vitreous cavity. Comparative study of sodium hyaluronate and hydroxypropylmethylcellulose].
We study the elimination of two viscoelastic substances from the vitreous cavity: the Hydroxypropyl Methylcellulose and the Sodium Hyaluronate that are potentially vitreous substitutes. We performed gas-vitrectomy in 116 eyes of 58 rabbits. Three days after surgery we performed gas-viscoelastic substance exchange. We analyzed the concentration of Hydroxypropyl Methylcellulose and Sodium Hyaluronate with diphenylamine reaction at different periods: zero, 1 week, 2 weeks, 1 month till 6 months. In both cases the elimination is fast so that 1 week after the intravitreal injection remains only 60.1% of the Hydroxypropyl Methylcellulose and 100% of Sodium Hyaluronate, and two weeks after 38.5% of Hydroxypropyl Methylcellulose and 62.5% of Sodium Hyaluronate. We conclude that both substances have a short half life-time specially in the case of the Hydroxypropyl Methylcellulose.
Fernandez-Vigo
J
J
Departamento de Oftalmologia, Universidad de Santiago de Compostela, España.
Sabugal
J F
JF
Diaz
J A
JA
Concheiro
A
A
Martinez
R
R
D000818:Animals; D006820:Hyaluronic Acid / Q000493:pharmacokinetics*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011817:Rabbits; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose
Elimination de substances visco-élastiques hors de la cavité vitréenne. Etude comparative entre l'hyaluronate sodique et l'hydroxy-propyl-méthyl-cellulose.