Effect of ponsinomycin on cyclosporin pharmacokinetics.
The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin. On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption. Ponsinomycin should be use very carefully in patients treated with cyclosporin A.
Couet
W
W
Service de Néphrologie, Hopital Pellegrin-Tripode, Bordeaux, France.
Istin
B
B
Seniuta
P
P
Morel
D
D
Potaux
L
L
Fourtillan
J B
JB
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D018942:Macrolides; D008297:Male; D008875:Middle Aged; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D018942:Macrolides