[The effect of noradrenaline on the neuronal reactions of the motor cortex evoked by conditional stimulation].
In chronic experiments on cats the influence of iontophoretic application of adrenomimetic ephedrin and beta-adrenoblocker obsidan (propranolol) on motor cortex neuron reactions following conditional stimuli was investigated under instrumental placing reaction. It was shown for a majority of neurons that the background impulse activity and reactions following conditional stimulation were suppressed by the influence of ephedrin and on the contrary were increased by obsidan application. It is concluded that there exists a consistent tonic suppressing influence of the noradrenergic system on background and evoked cortical neurons impulse activity in the natural state. It is supposed that noradrenergic influence temporal increase may serve as an important link in mechanisms of external inhibition during stress situations, aversive effects, and distractive external excitations.
Storozhuk
V M
VM
Stezhka
V V
VV
Ivanova
S F
SF
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000161:Acoustic Stimulation; D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004809:Ephedrine / Q000008:administration & dosage / Q000494:pharmacology; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology
D012701:Serotonin; D011433:Propranolol; D004809:Ephedrine; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie noradrenalina na reaktsii neĭronov dvigatel'noĭ kory, vyzvannye uslovnoĭ stimuliatsieĭ.