Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.
The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.
Takao
F
F
Laboratoire de Physiologie du Développement, CNRS UA 307, Université Paris VII, France.
Laury
M C
MC
Ktorza
A
A
Picon
L
L
Pénicaud
L
L
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D015309:Glucose Clamp Technique; D006019:Glycolysis; D006943:Hyperglycemia / Q000378:metabolism*; D006946:Hyperinsulinism / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007332:Insulin Infusion Systems; D009132:Muscles / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D003847:Deoxyglucose