Postmortem diagnosis of acute megakaryocytic leukemia. Usefulness of immunohistochemistry and tissue hemogram.
An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)-positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa-positive blasts and megakaryoblasts were deposited massively in lymph nodes. Immunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultrastructural platelet peroxidase in autopsy materials is difficult.
Umezawa
A
A
Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Yamada
T
T
Ogawa
Y
Y
Kuramochi
S
S
Watanabe
Y
Y
D000368:Aged; D001344:Autopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism
D010980:Platelet Membrane Glycoproteins