title: Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.
abstract: Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS.
authors: Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
authors: T L
authors: TL
authors: Perry
authors: C
authors: C
authors: Bergeron
authors: J C
authors: JC
authors: Steele
authors: D R
authors: DR
authors: McLachlan
authors: S
authors: S
authors: Hansen
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000378:metabolism; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005971:Glutamates; D013654:Taurine; D005680:gamma-Aminobutyric Acid