Leukocyte chemoattractant cytokines of the epidermis.
The constitutive production of interleukin-1 alpha-like material in normal human epidermis, its inflammatory properties, and the mechanism of its inflammatory action are briefly reviewed. The isolation of interleukin-8 from psoriatic lesions, its in vitro production, and leukocyte chemoattractant properties are also described. Available evidence suggests that interleukins-1 and -8 are inflammatory cytokines of major potential importance in the induction of leukocyte infiltrates in human skin.
Camp
R D
RD
Institute of Dermatology, St. Thomas's Hospital, London, United Kingdom.
Fincham
N J
NJ
Ross
J S
JS
Bacon
K B
KB
Gearing
A J
AJ
D002630:Chemotactic Factors / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism; D012867:Skin / Q000378:metabolism
D002630:Chemotactic Factors; D007375:Interleukin-1; D016209:Interleukin-8