Influence of the length of the small bowel graft on the severity of graft versus host disease.
The influence of the length and origin of a small bowel graft on graft versus host disease (GVHD) was studied in 33 (Lewis x brown Norway) F1 hybrids transplanted with different types of Lewis small bowel grafts. Recipients of an entire small bowel graft (N = 9), a jejunal graft (N = 6), or an ileal graft (N = 6) displayed a similar acute lethal GVHD, with 100% mortality rate and equivalent survival time (15 +/- 0.7, 16.8 +/- 0.9, and 16 +/- 0.6 days, respectively) (P greater than 0.01). On the other hand, 80% of the recipients of a segmental jejunal graft (N = 10) recovered from a transitory form of GVHD and regained weight similarly to the isografted rats (N = 4). It was concluded that the entire small bowel, jejunum, and ileum can provoke an equivalent GVHD after transplantation, whereas a segment of jejunum decreases the intensity of GVHD, probably by reducing the amount of transplanted lymphoid tissue.
Pirenne
J
J
Department of Surgery, University of Liege, Belgium.
D'Silva
M
M
Hamoir
E
E
Lardinois
F
F
Fridman
V
V
Mahieu
P
P
Honore
P
P
Meurisse
M
M
Jacquet
N
N
D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D000818:Animals; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D007082:Ileum / Q000473:pathology / Q000637:transplantation; D015994:Incidence; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D007583:Jejunum / Q000473:pathology / Q000637:transplantation; D008297:Male; D008866:Microsurgery / Q000379:methods; D051381:Rats; D011917:Rats, Inbred Lew; D015996:Survival Rate