Interleukin-1 affects the behavioral despair response in rats by an indirect mechanism which requires endogenous CRF.
Interleukin-1 (IL-1) administered intracerebroventricularly (i.c.v.) to rats significantly reduces the level of immobility in animals forced to swim in a confined space. Immunoneutralization of endogenous CRF (corticotropin-releasing factor) by i.c.v. administration of CRF-antiserum prevents the IL-1-induced sinking in rats. This shows that the release of cerebral CRF, probably from the hypothalamus, may mediate the behavioral effect promoted by IL-1. Taken together our results suggest the existence of a complex interface between immune, neuroendocrine and behavioral regulation.
del Cerro
S
S
Department of Psychobiology, CAJAL Institute, CSIC, Madrid, Spain.
Borrell
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming; D013997:Time Factors
D007375:Interleukin-1; D003346:Corticotropin-Releasing Hormone