Interleukin-4 as a potent inhibitor of bone resorption.
A possible role of interleukin-4 (IL-4) in the regulation of bone turnover was assessed by employing a 45Ca prelabeled-fetal mouse long bone culture system. IL-4 inhibited the bone resorption stimulated by parathyroid hormone (PTH), PTH related protein (PTHrP), 1 alpha, 25, dihydroxy-vitamin D3 [1 alpha, 25 (OH)2 D3], interleukin-1 alpha and - 1 beta (IL-1 alpha, IL-1 beta) and prostaglandin E2 (PGE2). Anti-IL-4 on monoclonal antibody abolished the inhibitory effect of IL-4 on the bone resorption. These results suggest that IL-4 may play an important role on the inhibitory regulation of bone resorption.
Watanabe
K
K
First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan.
Tanaka
Y
Y
Morimoto
I
I
Yahata
K
K
Zeki
K
K
Fujihira
T
T
Yamashita
U
U
Eto
S
S
D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects* / Q000196:embryology; D002117:Calcitriol / Q000494:pharmacology; D002478:Cells, Cultured; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D015847:Interleukin-4 / Q000494:pharmacology*; D051379:Mice; D011247:Pregnancy
D015847:Interleukin-4; D002117:Calcitriol; D015232:Dinoprostone