Chronic antihypertensive drug treatment decreases protein kinase C activity in platelets from SHR.
There is evidence that protein kinase C activity in platelets from adult SHR is significantly higher than this activity in age-matched WKY. In the present study, protein kinase C activity in the SHR was measured following antihypertensive drug treatment. Chronic administration of enalapril to SHR for 2 weeks decreased both systolic blood pressure and protein kinase C activity to the levels seen in the WKY. Similar results were obtained in case of chronic treatment of SHR with hydralazine or nifedipine. These results suggest that enhanced protein kinase C activity of SHR can be suppressed by lowering blood pressure by antihypertensive drugs.
Takaori
K
K
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Inariba
H
H
Itoh
S
S
Inoue
T
T
Kanayama
Y
Y
Takeda
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000201:enzymology*; D004656:Enalapril / Q000494:pharmacology; D006830:Hydralazine / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D011493:Protein Kinase C / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011921:Rats, Inbred WKY / Q000097:blood; D013997:Time Factors
D000959:Antihypertensive Agents; D006830:Hydralazine; D004656:Enalapril; D011493:Protein Kinase C; D009543:Nifedipine