Characterization of inflammatory cells in a patient with chronic periaortitis.
During repair of an inflammatory abdominal aortic aneurysm, fresh samples of the aneurysm wall were obtained. Histology confirmed the diagnosis of chronic periaortitis,- advanced atherosclerosis with medial attenuation, and periaortic inflammation. Monoclonal antibodies were used to identify the cells of the inflammatory infiltrate. The majority of the adventitial lymphocytes were B cells. No B cells were present in the atheroma. The majority of mature plasma cells contained IgG with a few plasma cells containing IgM. T cells, predominantly T helper cells, were found in the atheroma and adventitia. Positive DR staining was shown by the majority of lymphocytes, by macrophage-like cells in germinal centers of lymphoid follicles in the adventitia, by some vascular endothelial cells, and by some smooth muscle cells. The implications of these findings are discussed.
Parums
D V
DV
Nuffield Department of Pathology, John Radcliffe Hospital, Headington, Oxford, U.K.
Dunn
D C
DC
Dixon
A K
AK
Mitchinson
M J
MJ
D000911:Antibodies, Monoclonal; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D012185:Retroperitoneal Fibrosis / Q000276:immunology / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens