Dose-response characteristics of pancuronium in neonates, infants and children.
This paper presents pharmacodynamic data for pancuronium in neonates, infants, children and adolescents during N2O-O2-fentanyl anaesthesia. Neuromuscular block (NMB) was evaluated by the adductor pollicis electromyogram. Dose-response curves of pancuronium were parallel in all age-groups. ED95 was greatest in children and least in infants (93 vs. 66 micrograms/kg, P less than 0.05). The rate of spontaneous recovery following 95% NMB was comparable in all age-groups, as was the maintenance requirement of pancuronium when related to ED-values. The hourly requirement to maintain NMB greater than 85% was 60-68% of the individual ED95 dose. When administered on this basis, pancuronium is an equally long-acting neuromuscular blocking agent in patients of all ages.
Meretoja
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OA
Department of Anaesthesiology, Children's Hospital, University of Helsinki, Finland.
Luosto
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D000293:Adolescent; D000375:Aging / Q000502:physiology*; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000008:administration & dosage* / Q000494:pharmacology; D012044:Regression Analysis; D013874:Thiopental; D013997:Time Factors
D010197:Pancuronium; D013874:Thiopental; D005283:Fentanyl