The effect of the alpha-particle emitter astatine-211 in the mouse at the minimum toxic dose.
The radioactive halogen astatine-211 was injected into mice in an amount producing minimal toxicity. Histopathological examination of tissues at intervals between 3 d and 16 weeks showed the following changes: 1. Radiation-induced necrosis and progressive fibrosis of the thyroid gland. The gland was reduced to 25% of its original mass with only a few relatively normal follicles persisting. 2. A small, temporary, reduction in peripheral blood lymphocytes, platelets and red cells and a significant persistant increase in polymorphs. 3. Severe reduction in reproductive cells in the testis with some signs of recovery at 16 weeks.
Cobb
L M
LM
Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Didcot, Oxon, UK.
Butler
S A
SA
Harrison
A
A
D000818:Animals; D001246:Astatine / Q000633:toxicity*; D001345:Autoradiography; D001772:Blood Cell Count / Q000528:radiation effects; D004064:Digestive System / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013076:Sperm Count / Q000528:radiation effects; D013737:Testis / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects / Q000648:ultrastructure
D001246:Astatine