Osteopenia and phenylketonuria.
Trabecular bone mineral content was assessed by quantitative computed tomography in eleven young adults with phenylketonuria who had been treated from early childhood with a diet restricted in natural protein and supplemented with amino acids, minerals and vitamins. There was a significant reduction in the bone mineral content of patients compared with the normal population. Prospective studies are indicated in younger patients to ensure optimum bone mineralisation is achieved by adulthood.
Carson
D J
DJ
Department of Child Health, Queens University, Belfast, Northern Ireland.
Greeves
L G
LG
Sweeney
L E
LE
Crone
M D
MD
D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D004032:Diet / Q000009:adverse effects; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010661:Phenylketonurias / Q000000981:diagnostic imaging* / Q000178:diet therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed