title: Thrombogenicity and long-term patency in autologous vein, polytetrafluoroethylene (PTFE) and silk grafts in a sheep model: evaluated through the use of indium-III-labeled platelets.
abstract: Vascular conduits have different thrombogenicity and since platelet sequestration onto a graft surface is a contributing factor for subsequent graft occlusion, this constitutes an important feature. Most studies on thrombogenicity have been done as short-term experiments. In the present communication we have evaluated graft thrombogenicity for autologous vein, polytetrafluoroethylene (PTFE), and pure chinese silk grafts, immediately after graft implantation, 1, and 2 months thereafter, using Indium-111-labelled platelets, evaluated platelet consumption, and studied patency up to 4 months after graft implantation in a sheep model. The least thrombogenic graft material was found to be the autologous vein, followed by the silk graft and the PTFE graft. Already 1 month after graft implantation healing of the grafts seems to have occurred, resulting in a minimal detectable platelet sequestration. Platelet consumption by the graft can be seen as a decrease in platelet count in the peripheral blood. Four months after graft implantation the autologous vein grafts showed a patency rate of 71%, the silk grafts 55%, and the PTFE grafts 38%. The pure silk prosthesis revealed though at harvest of the grafts, a high incidence of aneurysmal graft dilatation.
authors: Department of Surgery, Faculty of Medicine, Kuwait University.
authors: J T
authors: JT
authors: Christenson
authors: A
authors: A
authors: Owunwanne
authors: M
authors: M
authors: Nazzal
mesh_terms: D000818:Animals; D001792:Blood Platelets; D001807:Blood Vessel Prosthesis; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000517:prevention & control; D007205:Indium Radioisotopes; D019476:Insect Proteins; D007601:Jugular Veins / Q000637:transplantation*; D008297:Male; D011138:Polytetrafluoroethylene; D011506:Proteins; D011877:Radionuclide Imaging; D012756:Sheep; D047011:Silk; D013784:Textiles; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D013997:Time Factors; D014654:Vascular Patency
chemical_list: D007205:Indium Radioisotopes; D019476:Insect Proteins; D011506:Proteins; D047011:Silk; D011138:Polytetrafluoroethylene