Existence of carcinine, a histamine-related compound, in mammalian tissues.
Carcinine (beta-alanylhistamine) was synthesized in vitro from histamine and beta-alanine. It was detected quantitatively using an HPLC method previously described for the quantification of the related compounds histamine, histidine, carnosine and 3-methylhistamine. Carcinine was identified in several tissue of the rat, guinea pig, mouse and human, and was then shown to be metabolically related in vivo to histamine, histidine, carnosine and 3-methylhistamine through radioisotopic labeling. The results demonstrate that carcinine may be concurrently quantitated using the same HPLC method as that used to measure histamine, histidine, carnosine and 3-methylhistamine. These findings suggest a role for carcinine in the carnosine-histidine-histamine metabolic pathway and in the mammalian physiologic response to stress.
Flancbaum
L
L
Dept. of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Brotman
D N
DN
Fitzpatrick
J C
JC
Van Es
T
T
Kasziba
E
E
Fisher
H
H
D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000737:chemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D009206:Myocardium / Q000737:chemistry; D010902:Pituitary Gland / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains
D006639:Histidine; D006632:Histamine; D002336:Carnosine; C015055:carcinine