Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells.
Fucoxanthin, a natural carotenoid prepared from brown algae, inhibited the growth of GOTO cells, a human neuroblastoma cell line. Fucoxanthin at 10 micrograms/ml reduced the growth rate of GOTO cells to 38% of the control at day 3 after drug treatment. Flowcytometric analysis revealed that fucoxanthin caused the arrest in the G0-G1 phase of cell cycle. Expression of N-myc gene was proved to be decreased by fucoxanthin as early as 4 h after treatment at 10 micrograms/ml and that may be important for the mechanism of anti-proliferative action of the carotenoid.
Okuzumi
J
J
1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Nishino
H
H
Murakoshi
M
M
Iwashima
A
A
Tanaka
Y
Y
Yamane
T
T
Fujita
Y
Y
Takahashi
T
T
D002338:Carotenoids / Q000031:analogs & derivatives* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004273:DNA, Neoplasm / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D016259:Genes, myc / Q000187:drug effects*; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology; D012334:RNA, Neoplasm / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects; D024341:Xanthophylls
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D024341:Xanthophylls; C025164:fucoxanthin; D002338:Carotenoids