L-cystein protects the pigment epithelium from acute sodium iodate toxicity.
Intravenous sodium iodate damages the retinal pigment epithelium, causing immediate loss of the electroretinogram c-wave and eventual pigmentary retinopathy. L-cystein, an agent that enhances the c-wave, has been reported to prevent the late development of pigmentary degeneration. We found in rabbits that L-cystein given 30 min before, or simultaneously with (but not 30 min after) sodium iodate also blocks the loss of the c-wave. This result occurred at doses of L-cystein lower than those needed to produce enhancement of the c-wave, suggesting that these two actions of L-cystein may be independent. The iodate-blocking action of L-cystein may depend on chemical interaction.
Heike
M
M
Department of Ophthamology, Stanford University School of Medicine, California.
Marmor
M F
MF
D000818:Animals; D003545:Cysteine / Q000494:pharmacology*; D004596:Electroretinography / Q000187:drug effects; D007452:Iodates / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010857:Pigment Epithelium of Eye / Q000187:drug effects*; D011817:Rabbits; D012162:Retinal Degeneration / Q000139:chemically induced / Q000517:prevention & control
D007452:Iodates; D003545:Cysteine; C032285:sodium iodate