Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2.
Il-2, the gene coding for the cytokine IL2 in the mouse, has been localized by in situ hybridization to bands 3B or 3C on Chromosome 3, where it joins five other genes that also map to 4q in humans. The Il-2 probe also produces a small, secondary grain peak on Chromosome 11, in the vicinity of band 11A5, the significance of which has not yet been determined. The gene for the alpha chain of the IL2 receptor in the mouse, Il-2ra, localizes to bands 2A2 or 2A3 on Chromosome 2. This is the first assignment of a gene located on chromosome 10 in humans to Chromosome 2 in the mouse.
Webb
G C
GC
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra.
Campbell
H D
HD
Lee
J S
JS
Young
I G
IG
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005796:Genes; D007376:Interleukin-2 / Q000235:genetics*; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000235:genetics*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2