Sub-femtomole quantitation of proteins with Threshold, for the biopharmaceutical industry.
The Threshold system provides for rapid quantitation of a variety of analytes at sub-femtomole levels, which is fewer than 6 x 10(8) molecules. The operating principles of the measurement system will be described, including the means for chemical modulation of the signal and the subsequent signal detection utilizing a proprietary silicon sensor. The Immuno-Ligand Assay is a universal ligand-binding assay system which provides quantitative measurement of proteins (including antibodies) in a variety of biological media. Assay performance will be described, along with data demonstrating sensitivity, precision and accuracy, for a variety of analytes of interest to the biopharmaceutical industry.
Briggs
J
J
Molecular Devices, Menlo Oaks Corporate Center, Menlo Park, CA.
Kung
V T
VT
Gomez
B
B
Kasper
K C
KC
Nagainis
P A
PA
Masino
R S
RS
Rice
L S
LS
Zuk
R F
RF
Ghazarossian
V E
VE
D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis; D004247:DNA / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation* / Q000379:methods; D007136:Immunoglobulins / Q000032:analysis; D051379:Mice; D011506:Proteins / Q000032:analysis*; D013997:Time Factors
D001426:Bacterial Proteins; D007136:Immunoglobulins; D011506:Proteins; D004247:DNA