[State of the organ of vision and behavior of rats after action on the eye of increased doses of UV-irradiation].
Male Wistar rats, weighing on the average 200 g, were used to investigate the clinical picture of photokerato-conjunctivitis and behavioral responses to the open field test after exposing their eyes to UV-radiation with an emission maximum at 302 nm. The development threshold for conjunctivitis was 0.6 kJ/m2 and that for keratitis was 0.8 kJ/m2. The corneal lesions such as perforation and formation of persistent (up to 60 days) changes emerged beginning with the dose 3 kJ/m2 (in 50% of animals). This dose is a minimally acting dose in terms of behavior. At the dose of 10 kJ/m2 the decrease of the horizontal motor activity, which was significant from day 14, became irreversible. Thus when the organ of vision is exposed to UV-radiation, it is important to take into consideration not only structural changes but also potential functional disorders, which are associated with enhancement of inhibitory processes in the CNS.
Lobacheva
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Galaktionova
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D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D003228:Conjunctiva / Q000528:radiation effects; D003231:Conjunctivitis / Q000209:etiology*; D003315:Cornea / Q000528:radiation effects; D005123:Eye / Q000528:radiation effects*; D007634:Keratitis / Q000209:etiology*; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
Sostoianie organa zreniia i povedenie krys posle vozdeĭstviia na glaza povyshennykh doz UF-izlucheniia.