Cancer occurring after radiotherapy and chemotherapy.
Radiotherapy and chemotherapy can effectively control cancer but can also cause new cancers to develop as long-term complications. Almost all types of cancer have been associated with radiotherapy. The breast, thyroid, and bone marrow are the organs most susceptible to radiation carcinogenesis. The bone marrow is also most frequently involved by chemotherapy and the leukemia risk is much higher than after radiotherapy. The combination of intensive radiotherapy and chemotherapy is particularly leukemogenic. The latent period between radiotherapy/chemotherapy and the appearance of a second primary cancer ranges from a few years to several decades. The risk for a second primary cancer following radiotherapy or chemotherapy emphasizes the need for life long follow-up of patients receiving such treatments. This is particularly the case in individuals with long life expectancy, for example, patients treated for childhood neoplasms. The benefits of radiotherapy and chemotherapy in oncology exceed the risks for second primary cancers. Efforts should be directed towards identifying those patients who will benefit from the treatments so that only they are exposed to the risk.
Holm
L E
LE
Department of Cancer Prevention, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology* / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D012306:Risk
D000970:Antineoplastic Agents