title: A muscle powered cardiac assist device for right ventricular support: total assist or partial assist?
abstract: A muscle powered cardiac assist device (MCAD) for right ventricular support requires optimized diastolic filling to obtain full stroke and acceptable fluid dynamics. A valved and spring-assembled skeletal muscle ventricle (SMV) was designed as a prototype MCAD, regardless of fluid dynamics. The present study addresses the optimal bypass method for right ventricular support, and predicts the future design for an implantable MCAD. Latissimus dorsi muscle (LDM) of 11 dogs were conditioned electrically for a one year maximum, and transformed into fatigue-resistant muscles (Type I fibers). Superior and inferior vena cavae were anastomosed using one arm of a Y-shaped vascular graft, as an inflow conduit, and the outflow conduit was placed on the main pulmonary artery. SMV was wrapped with transformed LDM and the bypass method was varied by SVC and/or IVC ligation. SMV demonstrated sufficient right ventricular support on total bypass (70% compared with control output), and the maximum pump off-to-on flow ratio (200%) was obtained. Maximum SMV power output was 0.27 X 10(6) erg, which was equivalent to that of canine right ventricle. Right atrial-to-pulmonary artery bypass was also constructed by using SMV in another 14 dogs, and also showed that total bypass was preferable for optimal SMV diastolic filling. In conclusion, specific requirements for a future MCAD include a subsystem assembly such as a spring, magnet, or alternative auxiliary muscle pump assembly for MCAD filling, and total bypass with optimized fluid dynamics and anatomic fitting.
authors: Department of Surgery (1), Kanazawa University School of Medicine, Ishikawa, Japan.
authors: N
authors: N
authors: Sakakibara
authors: G
authors: G
authors: Watanabe
authors: T
authors: T
authors: Misaki
authors: A
authors: A
authors: Mukai
authors: M
authors: M
authors: Tsubota
authors: H
authors: H
authors: Takemura
authors: Y
authors: Y
authors: Ohtake
authors: T
authors: T
authors: Iwa
mesh_terms: D000818:Animals; D001674:Bioelectric Energy Sources; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D004867:Equipment Design; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*