Early HIV-related neuropsychological impairment: relationship to stage of viral infection.
Sixty male outpatients with no past neuropsychiatric history were examined for evidence of early HIV-related neuropsychological impairment. Significant cognitive deficit, as measured by the RAVLT and WAIS-R Digit Symbol Substitution tests, and moderate correlation with indices of immune function, were observed in a group of patients with AIDS-Related Complex [ARC]. Patients with asymptomatic HIV-infection demonstrated no significant differences in performance compared to a group of HIV-seronegative controls. No significant group differences in age, education, predicted-IQ or self-rated depression and anxiety were observed. These results support the hypothesis that HIV-related cognitive disturbance occurs within the context of immunosuppression.
Gibbs
A
A
Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia.
Andrewes
D G
DG
Szmukler
G
G
Mulhall
B
B
Bowden
S C
SC
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D015492:AIDS Serodiagnosis / Q000523:psychology; D000386:AIDS-Related Complex / Q000175:diagnosis; D000328:Adult; D015331:Cohort Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000523:psychology; D006679:HIV Seropositivity / Q000175:diagnosis; D006716:Homosexuality / Q000523:psychology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011594:Psychometrics; D012803:Sick Role; D014888:Wechsler Scales