Anti-inflammatory effects of onions: inhibition of chemotaxis of human polymorphonuclear leukocytes by thiosulfinates and cepaenes.
Seven different synthetic thiosulfinates, and cepaene- and/or thiosulfinate-rich onion extracts were found to inhibit in vitro the chemotaxis of human granulocytes induced by formyl-methionine-leucine-phenylalanine in a dose-dependent manner and at a concentration range of 0.1-100 microM. Diphenylthiosulfinate showed the highest activity and was found to be more active than prednisolone. The anti-inflammatory properties of onion extracts are related, at least in part, to the inhibition of inflammatory cell influx by thiosulfinates and cepaenes.
Dorsch
W
W
Children's Hospital, Johannes-Gutenberg University, Mainz, FRG.
Schneider
E
E
Bayer
T
T
Breu
W
W
Wagner
H
H
D000328:Adult; D000490:Allium; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004220:Disulfides / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology*; D010936:Plant Extracts / Q000494:pharmacology; D013454:Sulfoxides / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004220:Disulfides; D010936:Plant Extracts; D013454:Sulfoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine