Development of chronic secondary epileptic foci following intrahippocampal injection of tetanus toxin in the rat.
It is known that injecting a minute dose of tetanus toxin into rat hippocampus leads to a chronic epileptic syndrome. Here we describe the development of secondary, 'mirror' epileptic foci in the hippocampus contralateral to a single injection of the toxin (12 mouse LD50). This was detected in slices in vitro prepared 6 to 56 days after injection, both as evoked after-discharges and as spontaneous synchronous bursts that were mainly restricted to subregions CA3b and c.
Jefferys
J G
JG
Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College, University of London.
Empson
R M
RM
D000818:Animals; D002908:Chronic Disease; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D006624:Hippocampus / Q000502:physiology*; D007267:Injections; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013744:Tetanus Toxin
D013744:Tetanus Toxin