[Diagnostic predictive value of C-reactive protein and expectant management of patients with premature rupture of the membranes].
To evaluate the predictive diagnostic value of CRP in a wait-and-see management of PROM 110 courses of labour and childbed with 114 babies were investigated with respect to both complications of mother and newborn. Complications during childbed could only be seen in 2.7%, 3.4% of the newborns suffered from septic disease. With regard to complications of newborns and mothers mediated by infection, CRP was demonstrated to have a prepartum sensitivity of 79% in combination with a specificity of 80%. The absolute highest sensitivity and specificity of CRP were found at a cut-off point of about 14 mg/l, which is clearly above the normal level of 6 mg/l serum. In almost 50% of the cases with maternal antepartum CRP levels up to 20 mg/l no pathogenic bacterial invasion could be revealed in the newborn. CRP therefore can be taken as an additional parameter in the management of PROM even in cases treated with corticosteroids due to its specificity and indicates better than WBC and polys when to terminate the wait-and-see attitude.
Krohn
M
M
Frauenklinik II, Bremen.
Pahnke
V G
VG
Albrecht
K
K
Trams
G
G
D000328:Adult; D001034:Apgar Score; D002097:C-Reactive Protein / Q000032:analysis*; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000209:etiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D012680:Sensitivity and Specificity
D002097:C-Reactive Protein
Diagnostische Aussagekraft von C-reaktivem Protein und exspektatives Management bei Patientinnen mit vorzeitigem Blasensprung.