[Factor VII and cardiovascular risk in obese subjects].
We investigated whether or not obesity is related to increased factor VII activity. We studied 70 obese subjects (aged 25 to 50 years, 25 males and 45 females, body mass index (BMI): mean +/- SD = 32.44 +/- 5.44) and 33 non-obese subjects (aged 25 to 50 years, 12 males and 21 females, BMI: mean +/- SD = 21.80 +/- 1.70). None of them were smokers or affected by hyperlipidemia, diabetes mellitus, impaired glucose tolerance or arterial hypertension. Factor VII activity was measured by the coagulometric method. We found higher factor VII activity in obese subjects (115.74 +/- 26.10%) than in healthy subjects (98.55 +/- 23.49%, p less than 0.005). Increased factor VII levels could determine a thrombophilic state involved in the genesis of cardiovascular accidents in obesity.
Craveri
A
A
Corsa Pareggiato di Semeiotica Medica dell'Università degli Studi di Milano.
Tornaghi
G
G
Ranieri
R
R
Paganardi
L
L
Torti
P
P
Marelli
F
F
Moroni
G A
GA
D000328:Adult; D001780:Blood Coagulation Tests; D002318:Cardiovascular Diseases / Q000209:etiology*; D005167:Factor VII / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors
D005167:Factor VII
Fattore VII e rischio cardiovascolare negli obesi.