Endothelin-1 levels are not influenced by tokishakuyakusan and keishibukuryogan treatment in women.
The effect of Tokishakuyakusan (TS) or Keishibukuryogan (KB) on endothelin-1 (ET-1), a newly identified peptide, in plasma and amniotic fluid from TS- or KB-treated women or normal pregnant women following TS or KB treatment was studied during the menstrual cycle, gestation, delivery and the post-partum period. ET-1 levels during and/or after TS or KB treatment had no significant changes when compared with those in TS- or KB-untreated women. These results suggest that TS or KB has no effects on the ET-1 level during the menstrual cycle, gestation and the post-partum period.
Usuki
S
S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood / Q000737:chemistry / Q000187:drug effects*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D016232:Endothelins; C054593:keishibukuryogan