title: [Activation of "silent" antibodies and their interaction with antigens].
abstract: Animal and human blood serum contains great amount of blocked (or "silent") immunoglobulins which, being activated by heating to 60 degrees C, pH decrease to 2.0-2.5 or treatment with 5M KSCN acquire a capacity to interact with different antigens. This interaction may be equally prevented or weakened by both identical and serologically non-related antigen, i.e. activated immunoglobulins are polyspecific. Polyspecific immunoglobulins show less affinity in comparison with monospecific antibodies, their interaction with antigens depends considerably on temperature.
authors: S A
authors: SA
authors: Bobrovnik
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D006433:Hemocyanins / Q000276:immunology; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007136:Immunoglobulins / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D013208:Staphylococcal Toxoid / Q000276:immunology
chemical_list: D000906:Antibodies; D007136:Immunoglobulins; D013208:Staphylococcal Toxoid; D010047:Ovalbumin; D006433:Hemocyanins
vernacular_title: Aktivatsiia "molchashchikh" antitel i ikh vzaimodeĭstvie s antigenami.