Synapse-to-neuron ratios in rat cerebellar cortex following lengthy periods of undernutrition.
Black and white hooded Lister rats were undernourished for various times up to 150 days of age; some of them were nutritionally rehabilitated from 75 days. Undernourished rats weighed significantly less than well-fed controls at all ages studied. After embedding in resin, sections of cerebellar cortex were cut and examined at the light and electron microscopical levels using traditional morphometric methods. Undernourished rats showed significant deficits in synapse-to-neuron ratio, compared with controls, at 21 days of age. This deficit disappeared by 75 days despite continued undernutrition. Indeed, there was no alteration in this ratio even when undernutrition was extended up to 150 days even though the ratio for the controls decreased after that period. Rats undernourished from birth to 75 days and subsequently rehabilitated to 150 days had significantly more synapses per neuron than controls. The functional sequelae of these morphological changes remain unknown.
Warren
M A
MA
Department of Biomedical Science, University of Sheffield, England.
Bedi
K S
KS
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D002525:Cerebellar Cortex / Q000648:ultrastructure*; D002531:Cerebellum / Q000473:pathology; D003677:Deficiency Diseases / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000648:ultrastructure*