[Possible mechanisms of hematoma formation in the urinary tracts in a patient with idiopathic thrombocytopenic purpura].
A 30-year-old female was admitted to our hospital complaining of hematuria and right flank pain in September, 1987. She had been diagnosed idiopathic thrombocytopenic purpura in 1980, and had similar symptoms before. Hematoma in the right ureter was demonstrated by retrograde pyelography and CT-scanning, and these symptoms improved within one month. Each activity of plasma clotting factors was within normal limits. Enzymatic studies of the urine revealed low values of plasmin-, urokinase-, and kallikrein-like activities in both excerbation and remission. These hemorrhagic tendencies might have been the result of marked thrombocytopenia: After bleeding into the urinary tracts began, the bleeding would tend to form hematoma because of elevated clotting activity; then hematoma would grow due to decreased urine fibrinolytic activities. This suggested that a decline of fibrinolysis in urine might have a promoting effect on the process of hematoma formation.
Nakamura
T
T
Department of Internal Medicine, Imamura Hospital, Kagoshima.
Homan
N
N
Kodama
C
C
Ohtubo
H
H
Hidaka
S
S
Kajiwara
Y
Y
Daitoku
Y
Y
Arima
N
N
Matsushita
K
K
Fukumori
J
J
D000328:Adult; D005260:Female; D005342:Fibrinolysis; D006406:Hematoma / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000652:urine; D014515:Ureteral Diseases / Q000209:etiology* / Q000503:physiopathology