title: Adrenal medullary hyperplasia. Hyperplasia-pheochromocytoma sequence.
abstract: We present a case of unilateral adrenal medullary hyperplasia in a 63-year-old woman with clinical signs and symptoms of pheochromocytoma unassociated with multiple endocrine neoplasia. The surgically removed adrenal gland revealed diffuse medullary hyperplasia with multiple micronodules measuring up to 2 mm. The micronodules were composed of enlarged chromaffin cells with atypia, histologically similar to those of pheochromocytoma, forming small solid alveolar patterns separated by a fibrovascular stroma. Removal of the hyperplastic adrenal gland resulted in disappearance of paroxysmal nocturnal hypertension and palpitation. These results suggest that diffuse and nodular medullary hyperplasia is the precursor of pheochromocytoma.
authors: Department of Pathology, Uwajima City Hospital, Japan.
authors: K
authors: K
authors: Kurihara
authors: K
authors: K
authors: Mizuseki
authors: T
authors: T
authors: Kondo
authors: H
authors: H
authors: Ohoka
authors: M
authors: M
authors: Mannami
authors: K
authors: K
authors: Kawai
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000209:etiology / Q000473:pathology; D000313:Adrenal Medulla / Q000378:metabolism / Q000473:pathology*; D002395:Catecholamines / Q000097:blood; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010673:Pheochromocytoma / Q000209:etiology / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D002395:Catecholamines; D010751:Phosphopyruvate Hydratase