[The modelling of the multiple drug resistance of the malarial parasites. 1. The combined resistance of Plasmodium berghei to chloroquine and fansidar].
Using a recurrent technique, P. berghei isolate resistant to chloroquine-fansidar combination is formed in golden hamsters. The isolate resistant to chloroquine-fansidar combination was 4 times less sensitive to chloroquine, 2 times less sensitive to fansidar and its combinations, 2 times less sensitive to sulfadoxine, 31 times less sensitive to pyrimethamine, as compared to the baseline isolate LNK65 P. berghei characterized by naturally reduced sensitivity to chloroquine.
Khanmirzoev
F I
FI
Kulikovskaia
I M
IM
Dadasheva
N R
NR
Rabinovich
S A
SA
D000818:Animals; D000962:Antimalarials / Q000037:antagonists & inhibitors*; D002738:Chloroquine / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D005260:Female; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008647:Mesocricetus; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects*; D011739:Pyrimethamine / Q000037:antagonists & inhibitors*; D013413:Sulfadoxine / Q000037:antagonists & inhibitors*
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine
Modelirovanie mnozhestvennoĭ lekarstvennoĭ ustoĭchivosti maliariĭnykh parazitov. Soobshchenie 1. Sochetannaia ustoĭchivost' Plasmodium berghei k khlorokhinu i fansidaru.