Decreased peripheral insulin sensitivity in acromegalic patients.
In 13 nondiabetic acromegalic patients glucose homeostasis was studied by use of the hyperglycaemic clamp technique and compared to a group of sex and age matched and a group of sex, age and weight matched controls. When compared to a control group of normal weight glucose stimulated insulin release (I) was significantly increased and tissue sensitivity to insulin (M/I) significantly decreased. However, no significant differences were observed when the parameters were compared with a weight matched group. Glucose stimulated insulin release correlated positively with growth hormone (GH) and somatomedin-C levels, whereas no such a correlation could be obtained for M/I. Thus, chronic growth hormone excess seems to induce hyperinsulinaemia which in turn leads to obesity and metabolic changes comparable to those of obesity.
Luger
A
A
Department of Medicine II, University of Vienna, Austria.
Prager
R
R
Gaube
S
S
Graf
H
H
Klauser
R
R
Schernthaner
G
G
D000172:Acromegaly / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism / Q000502:physiology; D013006:Growth Hormone / Q000097:blood; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D005947:Glucose