Thrombocytopenia following treatment with low doses of aminoglutethimide.
The authors report a case of severe thrombocytopenia during treatment with low doses of aminoglutethimide in a woman with advanced breast cancer. Hematologic toxicity secondary to aminoglutethimide did not seem to be dose-related, and an immunologic mechanism may be postulated. Although the incidence of the side effect is probably low, monitoring of blood counts during the first months of therapy is necessary.
Di Costanzo
F
F
Medical Oncology Service of Internal Medicine Institute, General Hospital S. Maria, Terni, Italy.
Brugia
M
M
Parriani
D
D
Bartolucci
R
R
D000616:Aminoglutethimide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced*
D000616:Aminoglutethimide