Anticonvulsant action of an arylamine-containing fraction from Agelenopsis spider venom.
A low molecular weight fraction (AG2) containing arylamine compounds has been isolated from venom of the spider Agelenopsis aperta. When administered intravenously or intracerebroventricularly, AG2 produces dose-dependent suppression of behavioral convulsions induced in rats by kainic acid, picrotoxin, or bicuculline. The low molecular weight compounds in spider venoms may provide novel tools for anticonvulsant research and therapy.
Jackson
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Department of Anatomy, University of Utah School of Medicine, Salt Lake City 84132.
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D000818:Animals; D000927:Anticonvulsants; D001640:Bicuculline / Q000037:antagonists & inhibitors; D001679:Biogenic Amines / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000037:antagonists & inhibitors; D008297:Male; D008970:Molecular Weight; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013111:Spider Venoms / Q000032:analysis*
D000927:Anticonvulsants; D001640:Bicuculline; D001679:Biogenic Amines; D007608:Kainic Acid; D010852:Picrotoxin; D013111:Spider Venoms