Polarographic study of nifurtimox.
Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4e process and subsequently the amine being formed in a 2e process at a pH value below 4. The C = N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond. The differential pulse polarographic peaks for the reduction of the nitro group to the hydroxylamine group at pH 6 were used in developing a new polarographic method for the determination of nifurtimox in pharmaceutical forms.
Squella
J A
JA
Electrochemistry Laboratory, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
Muñoz
W
W
Paulos
C
C
Nuñez-Vergara
L J
LJ
D002851:Chromatography, High Pressure Liquid; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D009547:Nifurtimox / Q000737:chemistry*; D011048:Polarography; D013607:Tablets
D013607:Tablets; D009547:Nifurtimox