[Relationship between molecular structure of halogenated methane compounds and their hypotensive effect in rats].
In this study gases of twelve halogenated methane compounds were administered by inspiration to Wistar rats in order to elucidate the relationship between molecular structure of the compounds and their hypotensive effect, and to develop new inhalational circulatory control agents. The correlation between the hypotensive effect of the compounds evaluated from the experimental data and computed van der Waals volume as well as surface area following molecular mechanics calculations of structure and energy, was investigated. The results showed that the compounds with van der Waals volume and surface area more than 73 A3 and 100 A2, respectively, had the hypotensive effect. In conclusion, our data suggest that the hypotensive effect of inhalational agents requires greater molecular sizes than regular ones.
Okuda
H
H
Department of Anesthesiology, Kansai Medical University, Moriguchi.
Hosoi
H
H
Mima
M
M
Uchida
M
M
Imanishi
T
T
Hachisuka
H
H
Ishiwari
K
K
D000280:Administration, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains
D006846:Hydrocarbons, Halogenated