The renal functions following a profound hypothermia in rats.
The aftereffects of renal function were studied in rats exposed to profound hypothermia and 5 min of cardiac arrest. All experimental rats were reanimated and survived at least 1 week. It was observed that the water intake and the basal renal excretion of urine, potassium and urea were decreased 24 hr after cooling, but did return to normal within 1 week. The renal handling of a large volume of infused saline was retarded 4 hr but recovered by the end of 24 hr after hypothermia. At both 4 and 24 hr after deep cooling, clearance of inulin and p-aminohippuric acid showed there were no change in glomerular filtration rate and effective renal plasma flow. It was concluded that the renal function was altered shortly after deep cooling and 5 min of cardiac arrest, however, this alteration could be completely recovered thereafter.
Chen
C F
CF
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Fang
H S
HS
D000818:Animals; D006400:Hematocrit; D007035:Hypothermia / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D011188:Potassium / Q000652:urine; D051381:Rats; D012121:Respiration, Artificial; D012964:Sodium / Q000652:urine; D014508:Urea / Q000652:urine; D014563:Urodynamics / Q000187:drug effects
D014508:Urea; D012964:Sodium; D011188:Potassium