Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation.
We demonstrated that thymocytes have significantly lower AChE activity, no mAChR binding capacity and the same nAChR binding value, that we can measure on PBLs. The expression of all these structures was changed due to mitogenic stimulation. There is a strong evidence that cholinergic modulation may play a role in T-cell differentiation.
Páldi-Haris
P
P
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Szelényi
J G
JG
Nguyen
T H
TH
Hollán
S R
SR
D000110:Acetylcholinesterase / Q000032:analysis*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000032:analysis*; D011978:Receptors, Nicotinic / Q000032:analysis*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D010835:Phytohemagglutinins; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D000110:Acetylcholinesterase