title: Isolation, synthesis, and evaluation of a series of indencarbazates as hypotensive agents.
abstract: Two indencarbazates, 1 and 2, were isolated from the sponge Cliona caribboea. These compounds were found to possess mild hypotensive activity. A series of analogues of 1 was synthesized in order to study the structure-activity relationship of this unique class of compounds. A variety of structural changes did not result in a consistent pattern of biological activity.
authors: Department of Medicinal Chemistry and Pharmacognosy, University of Houston, College of Pharmacy, TX 77204-5515.
authors: T L
authors: TL
authors: Lemke
authors: R
authors: R
authors: Sanduja
authors: M M
authors: MM
authors: Mroue
authors: S
authors: S
authors: Iyer
authors: M
authors: M
authors: Alam
authors: M B
authors: MB
authors: Hossain
authors: D
authors: D
authors: van der Helm
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000959:Antihypertensive Agents; D006834:Hydrazines; D007192:Indenes; C066937:caribbazoin A; C066938:caribbazoin B