Gall-bladder perforation after long-term dapsone therapy.
A 65-year-old man on maintenance dapsone therapy for dermatitis herpetiformis for 30 years was admitted to hospital with acute abdominal pain and vomiting. Investigations revealed a Heinz body haemolytic anaemia. Worsening symptoms prompted an emergency laparotomy that revealed a perforated gall bladder with pigmented biliary calculi. In previous reviews of the haematological abnormalities associated with dapsone therapy, life-threatening cholecystitis has not been described.
Choy
A M
AM
Department of Surgery, Ninewells Hospital, Medical School, Dundee, Scotland, UK.
Lang
C C
CC
D000006:Abdomen, Acute / Q000209:etiology; D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced; D002764:Cholecystitis / Q000139:chemically induced*; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D003874:Dermatitis Herpetiformis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013997:Time Factors
D003622:Dapsone