Retrograde transneuronal transport of wheat-germ agglutinin to the retina from visual cortex in the cat.
Injections of peroxidase-conjugated wheat-germ agglutinin (WGA-HRP) were made into areas 17 or 18 of cats. After survivals of 3-7 days, foci of HRP-labeled ganglion cells were found at the appropriate topographic locations in the retinas. The labeling was interpreted as resulting from retrograde transneuronal transport through the lateral geniculate nucleus. This phenomenon offers a new and simple technique for the study of retinotopic maps in visual cortex.
LeVay
S
S
Robert Bosch Vision Research Center, Salk Institute for Biological Studies, San Diego, CA 92138.
Voigt
T
T
D000818:Animals; D001693:Biological Transport, Active; D001931:Brain Mapping; D002415:Cats; D005724:Ganglia / Q000166:cytology / Q000378:metabolism; D006735:Horseradish Peroxidase; D009474:Neurons / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism*; D014909:Wheat Germ Agglutinins / Q000378:metabolism*
D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase