title: [tctN-mutation causing taillessness in mice heterozygous for gene T].
abstract: Screening of wild male mice trapped in Turkmenistan (Middle Asia) revealed a mouse with a mutation causing strong increase in expressivity of T mutation (Brachyury). A novel mutation was designated tctN-t complex tail interaction Novosibirsk. Compound heterozygotes T/tctN have tailless of extremely short tailed phenotype. Homozygotes tctN/tctN were completely viable and fertile. It was shown that the novel mutation was closely linked to T locus. Further genetic analysis showed that the chromosome with tct had no properties of t haplotypes: no lethal factors or the factors influencing fertility and segregation of homologoues; there was no effect on recombination frequency in the proximal part of chromosome 17 in tctN/+mice. The problems of t haplotype evolution are discussed.
authors: A I
authors: AI
authors: Agul'nik
authors: A O
authors: AO
authors: Ruvinskiĭ
authors: A V
authors: AV
authors: Poliakov
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D006239:Haplotypes; D006579:Heterozygote; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D011995:Recombination, Genetic; D013623:Tail
vernacular_title: tctN-mutatsiia, vyzyvaiushchaia beskhvostost' u mysheĭ, geterozigotnykh po genu T.