Mathematical model to analyse urea synthesis following alanine infusion in control subjects and in patients with liver cirrhosis.
A three-compartment model was used to analyse the urea response to an alanine infusion in control subjects and patients with liver cirrhosis. Discriminant analysis showed a good separation between model coefficients of the two groups. A single parameter was derived, able to quantify the liver functional capacity. The method provides a useful diagnostic tool in patients with liver disease.
Bolzani
R
R
Istituto di Clinica Oculistica, Università di Modena, Italy.
Bianchi
G P
GP
Marchesini
G
G
Sarti
E
E
D000409:Alanine / Q000378:metabolism*; D016002:Discriminant Analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000652:urine*; D008433:Mathematics; D008954:Models, Biological; D014508:Urea / Q000652:urine*
D014508:Urea; D000409:Alanine