Rheumatic fever susceptibility in four ascertainments: regressive segregation on a geometric ascertainment pattern.
On resolving the ascertainment biases of the observed data in the geometric continuum vaffected-1 x P(sibship), where 0 less than v----infinity, four published ascertainments of rheumatic fever show excellent conformation with Mendelian recessive segregation, even in multiplex sibships. In two surveys in which ascertainment bias is near or a little above random sampling (v = 1), this conclusion is further corroborated by classical segregation analysis. The other two surveys have bias trends declining (v less than 1) very much below random sampling. Such levels of ascertainment bias, if defined through the ascertainment probability parameter pi, would be out of range because the range is from single ascertainment, where pi----0 to random sampling where pi = 1 and probability cannot exceed unity. Highly successful antimicrobial measures that would reduce the number of diseased sibs independent of the distribution of susceptible sibs could produce a dissociation of the gene-to-"rheumatic" relationship and thus explains the declining ascertainment bias.
Sit
K H
KH
Department of Anatomy, National University of Singapore, Kent Ridge.
D000328:Adult; D002648:Child; D005808:Genes, Recessive; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008433:Mathematics; D012213:Rheumatic Fever / Q000235:genetics* / Q000276:immunology