Keratinocyte cytokines and growth factors. Functions in skin immunity and homeostasis.
Evidence has been presented to support the theory that the KC, by virtue of its production of cytokines and growth factors, is an integral component of the immune system. The production of cytokines by the KC is normally carefully regulated in order to maintain normal body homeostasis. Malfunction of the regulatory processes controlling cytokine release may result in the development of skin disease.
McKenzie
R C
RC
Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Sauder
D N
DN
D002455:Cell Division; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D006133:Growth Substances / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D015603:Keratinocytes / Q000276:immunology*; D012867:Skin / Q000166:cytology / Q000276:immunology* / Q000528:radiation effects
D016207:Cytokines; D006133:Growth Substances