[Clinical evaluation of serum S100ao protein in patients with urogenital diseases and healthy volunteers].
We investigated the clinical significance of the serum S100ao protein in patients with urogenital diseases. The serum levels of S100ao protein were measured in 179 patients with urogenital diseases and 180 healthy volunteers. The mean value of S100ao protein in serum from healthy volunteers was 203 +/- 107 pg/ml (Mean +/- SD). Therefore, the cut-off level was set to 524 pg/ml (Mean +/- 3SD). The levels of S100ao protein in serum were significantly higher in men than in women (P less than 0.05). The levels of S100ao protein in serum were significantly high in the patients in their fifties and sixties compared with the other patients (P less than 0.01). When serum levels exceeding the cut-off level were considered to be positive, the percentages of positivity in each disease were as follows: renal cell carcinoma; 38.7%, bladder tumor; 9.1%, prostatic carcinoma; 12.5%, testicular tumor; 0%, benign prostatic hypertrophy; 7.4%, urolithiasis; 7.1% and chronic renal failure; 100%. The levels of S100ao protein in serum were significantly correlated with those of BUN, serum creatinine and endogenous creatinine clearance, respectively. S100ao protein in serum was increased immediately after operation and returned to the normal range within one to two weeks after operation. As described above, the level of S100ao protein in serum was affected by renal function, operative procedures and age. However, the positive rate of S100ao protein was so high in patients with renal cell carcinoma that serum S100ao protein might be a valuable tumor marker in those patients.
Kikuchi
T
T
Department of Urology, Jichi Medical School.
Morita
T
T
Hashimoto
S
S
Hara
Y
Y
Moriguchi
H
H
Ishikawa
S
S
Kobayashi
Y
Y
Ishiyama
S
S
Goto
K
K
Tozuka
K
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000175:diagnosis; D005260:Female; D052776:Female Urogenital Diseases / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000175:diagnosis; D008297:Male; D052801:Male Urogenital Diseases; D008875:Middle Aged; D012016:Reference Values; D009418:S100 Proteins / Q000097:blood*; D012737:Sex Factors
D015415:Biomarkers; D014408:Biomarkers, Tumor; C030564:S-100 calcium-binding protein alpha subunit; D009418:S100 Proteins