Bone marrow cyto-morphological changes in multibacillary leprosy.
Seventy-two cases of multibacillary leprosy were investigated for cytomorphological changes and presence of lepra bacilli in bone marrow. These patients were divided in two groups. Group A (28) comprised of new cases and group B (44) of those receiving treatment. Myeloid hyperplasia was mostly seen in patients of group B who had erythema nodosum leprosum. Megaloblastic change in erythroblasts was seen frequently in both the groups. While average number of plasma cells and macrophages was on the higher side of normal range, detection of large number of plasma cells underlined enhanced humoral response and created diagnostic problem with multiple myeloma. Morphological changes in the macrophages, their collections and epithelioid cell granulomas were observed in bone marrow. Their nature and significance is discussed.
Sen
R
R
Department of Dermatology, Venerealogy and Leprosy, Medical College and Hospital, Rohtak.
Chaudhary
S D
SD
Dixit
V B
VB
Jain
V K
VK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology*; D004893:Erythema Nodosum / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D015440:Leprosy, Lepromatous / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology