Structural influences on intracellular cadmium mobilization by dithiols.
An examination of 5 dithiols, N-(2,3-dimercaptopropyl)phthalamidic acid (DMPA), benzene-1,2-dithiol (BDT), toluene-3,4-dithiol (TDT), alpha, alpha'-dimercapto-o-xylene (DOX), and 4,5-dimethyl-alpha,alpha'-dimercapto-o-xylene (DDOX), reveals that these compounds are all inferior to previously reported compounds as agents for the in vivo mobilization of cadmium from its intracellular sites, although all possess sulfhydryl groups capable of reacting with cadmium. The results demonstrate the considerable importance of those parts of the molecule which do not participate directly in the formation of chelate rings in the determination of the ultimate behavior of such compounds in vivo.
Jones
M M
MM
Department of Chemistry, Vanderbilt University, Nashville, TN 37235.
Gale
G R
GR
Singh
P K
PK
Atkins
L M
LM
Smith
A B
AB
D000818:Animals; D001822:Body Burden; D002104:Cadmium / Q000493:pharmacokinetics; D002105:Cadmium Poisoning / Q000188:drug therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D014018:Tissue Distribution
D002614:Chelating Agents; D013438:Sulfhydryl Compounds; D002104:Cadmium