[Pseudohypoparathyroidism and adrenal cortex insufficiency. A case of multiple endocrinopathy due to peripheral hormone resistance].
Since his childhood a now 31-year-old male showed typical symptoms of parathyroid hormone deficiency with hypocalcemia and hyperphosphatemia. We found a target organ resistance to parathyroid hormone and diagnosed pseudohypoparathyroidism. In addition adrenal insufficiency with hypocortisolism was seen. Both hormone systems act by stimulating adenylate cyclase. A defective receptor-adenylate cyclase complex may cause this--for the first time described--combination of endocrine insufficiency.
Ridderskamp
P
P
Heinrich-Heine-Universität, Abteilung Endokrinologie und Rheumatologie, Düsseldorf.
Schlaghecke
R
R
D000309:Adrenal Insufficiency / Q000150:complications*; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D002118:Calcium / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000172:deficiency / Q000627:therapeutic use; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D011547:Pseudohypoparathyroidism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D006728:Hormones; D010281:Parathyroid Hormone; D002118:Calcium; D006854:Hydrocortisone
Pseudohypoparathyreoidismus und Nebennierenrindeninsuffizienz. Ein Fall von Multipler Endokrinopathie bei peripherer Hormonresistenz.