[The immunomodulating action of interferon preparations. The effect of medicinal alpha-interferon preparations on the rosette-forming activity of human blood lymphocytes].
Effects of alpha-interferon (alpha-IF) medical preparations on human blood lymphocyte rosette-forming activity was under study. Blood samples from 40 donors and 81 patients with chronic pyoderma, lupus erythematosus, and pemphigus were examined. Interferon preparations alpha-IF for nasal administration and IN-1 and IN-2 (or leukinterferon) for injections were used. The results evidence that IF preparations activities depend on the methods of the preparation synthesis and purification. alpha-IF and leukinterferon most effectively enhanced the lymphocyte ability to spontaneous, early, and active rosette formation. IN-1 was found less active and enhanced only the ability to spontaneous E-rosette formation, but had no effect on early active E-RFC subpopulations. IF preparations elevated the counts of E-RFC anf active RFC only if these levels were lowered; if these values were normal the agents had no effect.
Avdeeva
Zh I
ZhI
Mazina
N M
NM
Lukasheva
T V
TV
Krylov
O R
OR
Kuznetsov
V P
VP
Medunitsyn
N V
NV
D000276:Adjuvants, Immunologic; D002908:Chronic Disease; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D010392:Pemphigus / Q000276:immunology; D011711:Pyoderma / Q000276:immunology; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D007370:Interferon Type I
K immunomoduliruiushchemu deĭstviiu preparatov interferona. Vliianie meditsinskikh preparatov al'fa-interferona na rozetkoobrazuiushchuiu aktivnost' limfotsitov krovi cheloveka.