[Manifestations of adaptive processes in the epithelium of the renal glomerular filter].
Fifteen kidney biopsy samples+, obtained from children suffering from the primary nephrotic syndrome, characterized with a high selective proteinuria and non-inflammatory character of changes in the renal corpuscles have been investigated after hormonotherapy (11 cases before and 4 cases 2-3 weeks after it). In podocytes certain disturbances in the lysosomal-vascular apparatus develop with a successive appearance of degeneration, desquamation and even necrosis of these cells. After prednisolone++ treatment edema of cytoplasm of the cells and their processes disappears, amount and size of the filtration slits are partly restored.
Val'kovich
E I
EI
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D002648:Child; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009402:Nephrosis, Lipoid / Q000188:drug therapy / Q000473:pathology* / Q000652:urine; D011239:Prednisolone / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy / Q000473:pathology*
D011239:Prednisolone
Proiavleniia adaptatsionno-prisposobitel'nykh protsessov v épitelii klubochkovogo fil'tra pochek.