title: Elevation of skeletal muscle isoform of serum creatine kinase in heterozygous familial hypercholesterolaemia.
abstract: Serum creatine kinase (CK) is an important adjunct in the diagnosis of myocardial infarction or in monitoring for the side-effects of drugs. We report elevation of CK in patients with untreated heterozygous familial hypercholesterolaemia (FH) with no evidence of myocardial infarction. Of a group of 30 patients, 60% had elevated CK values on one occasion. In 40% of patients elevated CK activity was observed on most occasions. This was not related to exercise or previous lipid-lowering therapy. These observations are of importance in view of the potential for misdiagnosis of myocardial infarction or premature withdrawal of lipid-lowering therapy.
authors: University Department of Medicine, Manchester Royal Infirmary, UK.
authors: D
authors: D
authors: Bhatnagar
authors: P N
authors: PN
authors: Durrington
authors: R
authors: R
authors: Neary
authors: J P
authors: JP
authors: Miller
mesh_terms: D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000201:enzymology*; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase