title: In vivo neurochemical effects of tail pinch.
abstract: Tail pinch in the rat gives rise to a well characterised pattern of behaviour which includes gnawing, licking and eating. We have used both in vivo voltammetry and microdialysis to monitor neurochemical changes which accompany the behavioural response to a 5-min tail pinch. Tail pinch resulted in a increase of extracellular 5-hydroxytryptamine and a smaller and more delayed increase of 5-hydroxyindole acetic acid in the hippocampus. In the striatum there was a rise of both extracellular dopamine and ascorbate. With a recently developed constant potential voltammetric technique we can continuously monitor changes in extracellular ascorbate. Using this technique we found a very rapid rise in ascorbate current during a 5-min tail pinch; the current began to decline as soon as the clip was removed. The high time resolution of the technique also allowed us to record similar ascorbate changes during a 0.5-s tail pinch.
authors: University Laboratory of Physiology, Oxford, U.K.
authors: M G
authors: MG
authors: Boutelle
authors: T
authors: T
authors: Zetterström
authors: Q
authors: Q
authors: Pei
authors: L
authors: L
authors: Svensson
authors: M
authors: M
authors: Fillenz
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000737:chemistry / Q000378:metabolism; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D010146:Pain / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism; D013623:Tail / Q000502:physiology
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D001205:Ascorbic Acid; D004298:Dopamine; D006719:Homovanillic Acid