[Antioxidative properties of glycyrrhyzic acid salts and their effect on the liver monooxygenase system].
Antioxidative activity of potassium- and sodium glycyrrhizins was detected by means of chemoluminescence procedure. As shown by the spectral studies the glycyrrhizin salts formed complex of the I type with cytochrome P-450 from rat liver microsomes, inhibited inactivation of isolated cytochrome P-450LM2 and induced hemoprotein formation after administration into rats. The preparations of glycyrrhizic acid appear to be useful for treatment of toxic impairment of liver tissue.
Abdugafurova
M A
MA
Li
V S
VS
Sherstnev
M P
MP
Atanaev
T B
TB
Isamukhamedov
A Sh
ASh
Bachmanova
G I
GI
D000818:Animals; D000975:Antioxidants; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D004790:Enzyme Induction; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D008163:Luminescent Measurements; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D065607:Cytochrome P-450 Enzyme Inhibitors; D019695:Glycyrrhizic Acid; D003577:Cytochrome P-450 Enzyme System; D006034:Glycyrrhetinic Acid
Issledovanie antiokislitel'nykh svoĭstv soleĭ glitsirrizinovoĭ kisloty i ikh vliianiia na mikrosomal'nuiu monooksigenaznuiu sistemu pecheni.