Exploration of the atherosclerotic plaque.
During the past 3 decades we have achieved a better understanding of the atherosclerotic process. It has been described as a series of changes in the intima of arteries consisting of the focal accumulation of lipids, complex carbohydrates, blood and blood products, fibrous tissues, and calcium that are also associated with changes in the media. The process begins with a vascular injury that is complicated by the deposition of cholesterol esters and cholesterol. It is followed by the accumulation of lipid ladened monocytes as well as the initiation of immune mechanisms. The proliferation of smooth muscle cells into the lesion assures its permanence by the synthesis of fibrous tissue. Platelet aggregation, thrombosis and hemorrhage are all key components of plaque progression, that ultimately are associated with vascular occlusion and focal vascular spasm. Calcium plays an important role in the development of hard, ulcerated lesions. Atherosclerotic risk factors are believed to accelerate the progression of atherosclerotic plaques and the control of these risk factors may retard their proliferation and progression.
Ip
J H
JH
Department of Medicine, Mount Sinai Medical Center, New York, NY.
Fuster
V
V
Chesebro
J H
JH
D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology*; D001792:Blood Platelets / Q000502:physiology; D001808:Blood Vessels / Q000293:injuries; D002118:Calcium / Q000502:physiology; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology; D009000:Monocytes / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D012307:Risk Factors
D008074:Lipoproteins; D002118:Calcium