Magnetic resonance imaging of experimental rat brain tumors: histopathological evaluation.
Using RG-C6 glioma-transplanted rats, we studied precontrast and postcontrast magnetic resonance imaging, extravasation of Evans blue, and histology. In all rats, tumor was enhanced with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). The necrotic portion in the tumor, however, was not enhanced. Hemorrhage and hydrocephalus were clearly visualized on both the precontrast and postcontrast images. Blood-brain barrier-disrupted areas stained with Evans blue and areas enhanced with Gd-DTPA on magnetic resonance imaging were nearly consistent. It is suggested that the mechanism of brain tumor enhancement with Gd-DTPA on magnetic resonance imaging is simply related to the degree of alteration of the blood-brain barrier. The Gd-DTPA-enhanced magnetic resonance imaging, even with low magnetic field, is useful for the evaluation of size, shape, and location of experimental rat brain tumors.
Baba
T
T
Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Moriguchi
M
M
Natori
Y
Y
Katsuki
C
C
Inoue
T
T
Fukui
M
M
D000818:Animals; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D003287:Contrast Media; D004195:Disease Models, Animal; D005070:Evans Blue; D019786:Gadolinium DTPA; D005910:Glioma / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003287:Contrast Media; D009942:Organometallic Compounds; D005070:Evans Blue; D004369:Pentetic Acid; D019786:Gadolinium DTPA