Phytohaemagglutinin-induced neutrophil aggregation in patients affected by chronic myeloproliferative diseases.
The aim of this work was to evaluate the phytohaemagglutinin-induced aggregation of circulating neutrophils isolated from 25 patients affected by chronic myeloproliferative syndromes (polycythaemia vera, chronic myeloid leukaemia in chronic phase, and essential thrombocythaemia). The results showed a lesser aggregating capacity in chronic myeloid leukaemia (CML) and an opposite behaviour in polycythaemia vera and essential thrombocythaemia. Patients with polycythaemia vera whose neutrophils showed a greater aggregating capacity were shown to have had various vascular complications.
Carulli
G
G
Clinica Medica I, Universitá di Pisa, Italy.
Baicchi
U
U
Marini
A
A
Vaglini
F
F
Grassi
B
B
Ambrogi
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002449:Cell Aggregation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*
D010835:Phytohemagglutinins