Replacement of L-T4 suppository in MMI treated rabbits.
L-T4 suppositories containing 50, 100 or 200 micrograms of L-T4 were given to rabbits treated with MMI. The serum T4 gradually increased within 3.5 and 6.5 hours following the use of 100 and 200 micrograms of L-T4 suppositories, respectively, without an acute increase in serum T3. The increase in serum T4 continued up to 48 hours. The area under the curve (AUC) for serum T4 was evidently dose-dependent. It is concluded from these results that the T4 suppository will be useful as a replacement therapy for patients with hypothyroidism.
Yamamoto
M
M
Hospital of East Japan Railway Company, Miyagi.
Yonezawa
K
K
Mizugaki
M
M
Toda
H
H
Kikuchi
H
H
Sakurada
T
T
Saito
S
S
Yoshinaga
K
K
D000818:Animals; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy*; D008713:Methimazole; D011817:Rabbits; D013488:Suppositories; D013974:Thyroxine / Q000008:administration & dosage* / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013488:Suppositories; D014284:Triiodothyronine; D008713:Methimazole; D013974:Thyroxine