Gametocytocidal activity of the antimalarial alpha/beta arteether against Plasmodium cynomolgi B.
A new sesquiterpene lactone alpha/beta arteether (a 30:70 mixture of enantiomers), which possesses very high blood schizontocidal activity, has been evaluated for gametocytocidal/sporontocidal action against Plasmodium cynomolgi B infection in the rhesus monkey. This paper reports gametocytocidal action of this new antimalarial drug at 2.5-5 mg/kg (single im dose) against P. cynomologi B as shown by the complete absence of mosquito infectivity. No sporontocidal action was demonstrable in the vector at a dose of up to 20-50 mg/kg im.
Tripathi
R
R
Central Drug Research Institute, Lucknow, India.
Dutta
G P
GP
Vishwakarma
R A
RA
D000818:Animals; D000852:Anopheles / Q000472:pathogenicity; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D008253:Macaca mulatta; D010270:Parasite Egg Count; D010961:Plasmodium / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013170:Spores / Q000187:drug effects*; D015053:Zygote / Q000187:drug effects*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil