Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein.
Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Protein Z is synthesized with a prepro-leader sequence of 40 amino acids. The mature protein is composed of 360 residues including a Gla domain of 13 carboxyglutamic acid residues, two epidermal growth factor domains, and a carboxyl terminal region which is highly homologous to the catalytic domain of serine proteases. Human protein Z, however, contains an Asp instead of Ser and a Lys instead of His in the catalytic triad of the active site.
Ichinose
A
A
Department of Biochemistry, University of Washington, Seattle 98195.
Takeya
H
H
Espling
E
E
Iwanaga
S
S
Kisiel
W
W
Davie
E W
EW
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D001798:Blood Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry*; D015698:Genomic Library; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000737:chemistry*; D008969:Molecular Sequence Data; D021382:Protein Sorting Signals / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D001798:Blood Proteins; D006023:Glycoproteins; D021382:Protein Sorting Signals; C026080:plasma protein Z; D004247:DNA