Xeroderma pigmentosum: clonal chromosomal rearrangements in a pre-cancerous skin lesion.
In cells from a papulonodular formation of a patient with the clinical and cellular phenotype of the variant form of xeroderma pigmentosum (XP-V), clonal rearrangements involving different chromosomes were observed. This finding confirms the literature data suggesting that multiple non-specific chromosome anomalies are typical of pre-malignant and malignant skin lesions.
Chessa
L
L
Cattedra di Genetica Medica, Università La Sapienza, Roma, Italy.
Nuzzo
F
F
Stefanini
M
M
Lagomarsini
P
P
del Porto
G
G
D000328:Adult; D002280:Basal Cell Carcinoma / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000648:ultrastructure; D003241:Consanguinity; D004260:DNA Repair; D005153:Facial Neoplasms / Q000209:etiology; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects / Q000648:ultrastructure; D005819:Genetic Markers; D006801:Humans; D008545:Melanoma / Q000209:etiology; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D010375:Pedigree; D011230:Precancerous Conditions / Q000209:etiology / Q000235:genetics*; D011836:Radiation Tolerance; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000150:complications / Q000235:genetics*
D005819:Genetic Markers