title: Methapyrilene: DNA as a possible target.
abstract: The structural features contributing to the potential carcinogenicity, DNA-reactivity and genotoxicity of methapyrilene and its non-carcinogenic congener pyrilamine were examined. The analyses suggest that the former has the potential for DNA-reactivity, a property which is absent from the latter.
authors: Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
authors: H S
authors: HS
authors: Rosenkranz
authors: G
authors: G
authors: Klopman
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004249:DNA Damage; D008701:Methapyrilene / Q000633:toxicity*; D051379:Mice; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens; D011738:Pyrilamine / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D002273:Carcinogens; D009153:Mutagens; D008701:Methapyrilene; D011738:Pyrilamine