[Radiation enteritis: mucosal regeneration and stromal reaction of the small intestine after irradiation].
D-glucose absorption in vivo in mice decreased as a function of dose and time after irradiation returning to normal within a week after irradiation. The lamina propria is seen full of polymorphonuclear leukocytes, other infiltrative cells, capillary and lymphatic network, which seem closely related to chronic enteritis. Since acute and chronic diarrhea after irradiation can be reduced by cholestyramine or acetylsalicylate, malabsorption of bile salts or prostaglandin E of the luminal content has been regarded as a cause of radiation-induced diarrhea. LD 50 of irradiated mice was increased by SOD. From the clinical data, thin physique, previous operation, and total dose of more than 50 Gy could be predisposing factors of radiation-related enteritis.
Matsui
M
M
Dept. of Radiotherapy, Tochigi Cancer Center.
Jingu
K
K
Masuda
K
K
Kamura
T
T
Tsukamoto
N
N
Matsuyama
T
T
Overgaard
J
J
D000328:Adult; D000368:Aged; D004751:Enteritis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000503:physiopathology*; D007415:Intestinal Obstruction / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000503:physiopathology / Q000532:radiotherapy; D011832:Radiation Injuries / Q000473:pathology / Q000503:physiopathology*; D012038:Regeneration; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*