Initial evaluation of variable graft lengths and lesion lengths in the repair of nerve gaps.
This experiment evaluated the electrical and histologic differences between two groups of rats, one of which underwent same-length bilateral resection of posterior tibial nerves prior to being repaired with grafts of different lengths, while the other group underwent different-length resections with same-length graft repair. In this rat model, 18 animals were used and divided into two groups. The first group of animals underwent bilateral resection of 8-mm segments of posterior tibial nerve. To repair these nerves, one leg received two 8-mm sural nerve grafts (Group A), while the other leg received two 16-mm sural nerve grafts (Group B). The second group of rats underwent posterior tibial nerve resections of 8 mm and 16 mm, respectively. The leg with the 8 mm of posterior tibial nerve resected, received two side-by-side 16-mm sural nerve grafts (Group C); the other leg with 16 mm resected, received two 16-mm sural nerve grafts (Group D). Electrophysiologic comparison of nerve conduction velocity for Groups A and B showed a significant difference (p less than 0.05), as did the same comparison for Groups C and D (p less than 0.05). Histologic studies showed that Groups A and D had marked extrafascicular escape of the regenerating nerve axons, disorganizational growth of minifascicles, and loss of integrity of the donor fascicles, while Groups B and C had very minimal extrafascicular escape of regenerating axons.(ABSTRACT TRUNCATED AT 250 WORDS)
Kim
D H
DH
Department of Neurosurgery, Ochsner Clinic, New Orleans, LA 70121.
Connolly
S E
SE
Voorhies
R M
RM
Beuerman
R W
RW
Kline
D G
DG
D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000473:pathology / Q000502:physiology; D004576:Electromyography; D005071:Evoked Potentials; D009132:Muscles / Q000294:innervation / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009431:Neural Conduction; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D012584:Sciatic Nerve / Q000473:pathology / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology / Q000637:transplantation*; D013979:Tibial Nerve / Q000473:pathology / Q000601:surgery*