Intracellular transport of class II MHC molecules directed by invariant chain.
Three structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endoplasmic reticulum retention signal in the full-length li suggests a role for li in the alpha-beta heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds alpha-beta dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.
Lotteau
V
V
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
Teyton
L
L
Peleraux
A
A
Nilsson
T
T
Karlsson
L
L
Schmid
S L
SL
Quaranta
V
V
Peterson
P A
PA
D000911:Antibodies, Monoclonal; D001483:Base Sequence; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D015345:Oligonucleotide Probes; D015398:Signal Transduction; D014162:Transfection
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes