[Proliferative and differentiation properties of bone marrow hematopoietic stem cells in CBA mice of various ages].
Hemopoietic bone marrow stem cells (CFCs) of young (3-5 months) and old (23-24 months) were studied according to their ability to form colonies in spleens of the lethally irradiated animals. The number, morphology and volume of CFCs were microscopically examined. The content of CFCs remained unchanged during aging. The number of erythroid colonies decreased in old mice, while that of granulocyte-macrophage and mixed colonies did not change. The megakaryocyte colonies showed even an increase with age. Volumes of all the colony types, except megakaryocyte, reduced. The results obtained thus reflect some age-related features of early stages of the stem-cell differentiation.
Andrianova
L F
LF
Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev.
D000375:Aging / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000166:cytology; D005260:Female; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008264:Macrophages / Q000166:cytology; D008533:Megakaryocytes / Q000166:cytology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology
Proliferativnye i differentsirovochnye svoĭstva stvolovykh krovetvornykh kletok kostnogo mozga u mysheĭ linii CBA razlichnogo vozrasta.