Regulation of proliferation, invasion and growth factor synthesis in breast cancer by steroids.
Endogenous ovarian estrogens and progestins appear to play a critical role in the development and progression of breast cancer. Local productions of growth factors probably also contribute to malignant proliferation, while production and activation of collagenolytic enzymes may be equally critical for local invasive processes. The current review focuses on characterization of growth factor-receptor systems operant in normal and malignant breast epithelium. In addition, the determinants of local invasion are reviewed: attachment, modality, and proteose secretion. Finally, data are discussed concerning the regulation of both proliferation and invasion by hormones and antihormonal agents in hormone-dependent breast cancer. The results suggest new potential pharmacologic targets to explore to suppress onset and progression of breast cancer.
Dickson
R B
RB
Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC 20007.
Thompson
E W
EW
Lippman
M E
ME
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000502:physiology*; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D013256:Steroids / Q000494:pharmacology / Q000502:physiology*
D004965:Estrogen Antagonists; D004967:Estrogens; D006133:Growth Substances; D013256:Steroids