[Effectiveness of synthetic opioid peptide dalargin in acute myocardial infarction].
The synthetic opioid peptide dalargin was examined for its potency in 86 patients with primary transmural myocardial infarction. The agent was shown to contribute to a decrease in initially elevated plasma cortisol levels and an increase in beta-endorphine and leucine-enkephaline concentrations. Myocardial contractility became normal by reducing the hyperfunction of its intact segments. This was evidenced by antistressor effects of the drug. However, no substantial effect was found on the clinical course of the disease, evolution of myocardial infarction, plasma CPK MB. The left ventricular contractility showed severe depression.
Golikov
A P
AP
Riabinin
V A
VA
Zholudev
A A
AA
Luk'ianov
M M
MM
Avilova
O A
OA
D000328:Adult; D000368:Aged; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D013565:Sympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D001615:beta-Endorphin / Q000097:blood
D007527:Isoenzymes; D013565:Sympatholytics; D001615:beta-Endorphin; D016308:Enkephalin, Leucine-2-Alanine; D003402:Creatine Kinase; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D006854:Hydrocortisone
Effektivnost' sinteticheskogo opioidnogo peptida dalargina pri ostrom infarkte miokarda.