title: Frequency of administration of growth hormone--an important factor in determining growth response to exogenous growth hormone.
abstract: Growth hormone (GH) secretion in man occurs in a pulsatile manner with a dominant periodicity of 200 min. Animal studies and growth hormone-releasing hormone therapeutic studies in man demonstrate the importance of the frequency of GH pulses on the growth response observed. Daily injections of GH produce effective growth. More frequent regimens may be beneficial to prevent waining of the growth spurt induced by GH therapy.
authors: Endocrine Unit, Middlesex Hospital, London, UK.
authors: P C
authors: PC
authors: Hindmarsh
authors: R
authors: R
authors: Stanhope
authors: M A
authors: MA
authors: Preece
authors: C G
authors: CG
authors: Brook
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage; D051381:Rats
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D013006:Growth Hormone