Pharmacokinetics of an infusion of propofol during cardiac surgery.
We have measured whole blood concentrations and pharmacokinetics of propofol administered as a constant rate infusion during cardiac surgery. Ten patients undergoing elective cardiac surgery involving cardiopulmonary bypass (seven myocardial revascularization and three aortic valve surgery) received a continuous infusion of propofol 4 mg kg-1 h-1 to supplement alfentanil analgesia. Whole blood propofol concentrations were measured by high pressure liquid chromatography. A concentration greater than 1 microgram ml-1 was achieved within 15 min of starting the infusion and remained constant throughout surgery. Volume of distribution, clearance and terminal half-life were similar to those found in non-cardiac patients.
Massey
N J
NJ
Department of Anaesthesia, Northern General Hospital, Sheffield.
Sherry
K M
KM
Oldroyd
S
S
Peacock
J E
JE
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D001021:Aortic Valve / Q000601:surgery; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009204:Myocardial Revascularization; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics*
D015742:Propofol