Nonlinear estimation of kinetic parameters for solid-state hydrolysis of water-soluble drugs. II: Rational presentation mode below the critical moisture content.
A logical presentation mode for accelerated data obtained at low relative humidities has been developed. A model is proposed leading to an equation relating the percent decomposition, x, at time t, to the temperature (T, K), and the water vapor (P, mmHg) in an open system. The data presented support the equation.
Yoshioka
S
S
National Institute of Hygienic Sciences, Tokyo, Japan.
Carstensen
J T
JT
D006813:Humidity; D006868:Hydrolysis; D007700:Kinetics; D002504:Meclofenoxate / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000032:analysis
D004364:Pharmaceutical Preparations; D014867:Water; D002504:Meclofenoxate