title: The influence of clinical and pharmacological factors on enuresis treatment with imipramine.
abstract: 1. The aim of this study has been to evaluate the response to imipramine treatment in enuretic children through the use of a series of clinical and pharmacological variables and by applying a multivariate (principal components) analysis technique. 2. The study was carried out on 146 children whose ages ranged from 5 to 14 years, and who received variable doses of imipramine (12.5 to 100 mg day-1). 3. The quantitative variables analyzed were: drug dosage, serum levels of imipramine and its metabolite desipramine, the relationship between them both, the duration of treatment, age and weight. 4. The qualitative variables were: compliance, presence of side-effects, enuretic and/or psychiatric antecedents, intelligence quotient (I.Q.), the existence (or absence) of related pathologies, sex, and the type of enuresis. 5. The response to treatment was quantified by means of the percentage of decrease in frequency of enuresis as compared with the initial frequency. 6. The results obtained show that the variables which are most associated with the reduction of enuresis are, in decreasing order: the dosage of imipramine administered, the duration of treatment, compliance and the level/dose ratio for the sum of the drug and metabolite levels.
authors: Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.
authors: M M
authors: MM
authors: Fernández de Gatta
authors: P
authors: P
authors: Galindo
authors: F
authors: F
authors: Rey
authors: J
authors: J
authors: Gutierrez
authors: M
authors: M
authors: Tamayo
authors: M J
authors: MJ
authors: García
authors: A
authors: A
authors: Domínguez-Gil
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003891:Desipramine / Q000097:blood; D004775:Enuresis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D007099:Imipramine; D003891:Desipramine