title: Bactericidal activity of magainin 2: use of lipopolysaccharide mutants.
abstract: Salmonella typhimurium and a series of rough lipopolysaccharide mutants derived from it were used as target bacteria to examine the antimicrobial capacity of magainin 2. Magainin 2 demonstrated a dose-related bactericidal activity against the smooth parent strain and the series of lipopolysaccharide mutants. The lipopolysaccharide mutant series showed an ordered increase in sensitivity to the magainin 2 as the depth of the rough lesion in the lipopolysaccharide increased.
authors: Department of Zoological and Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens 45701.
authors: E A
authors: EA
authors: Macias
authors: F
authors: F
authors: Rana
authors: J
authors: J
authors: Blazyk
authors: M C
authors: MC
authors: Modrzakowski
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D002240:Carbohydrate Sequence; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides / Q000235:genetics; D054806:Magainins; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D029867:Xenopus Proteins
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D054806:Magainins; D010455:Peptides; D029867:Xenopus Proteins; C053301:magainin 2 peptide, Xenopus