Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects.
Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n = 27) had a lower prolactin response to haloperidol than did the controls (n = 28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n = 7), and those with other psychoses (n = 12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia.
Copolov
D L
DL
National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria.
Keks
N A
NA
Kulkarni
J
J
Singh
B S
BS
McKenzie
D
D
McGorry
P
P
Hill
C
C
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000097:blood; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood*; D012559:Schizophrenia / Q000097:blood*
D011388:Prolactin; D006220:Haloperidol