[The characteristics of the enzyme status of the antioxidant protection and the level of lipid peroxidation in the brain tissue and blood of rats with differing preferences for ethanol].
The ethanol-preferring (EP) rats have a higher level of lipid peroxidation in the brain and blood serum than the water-preferring rats. At the same time it was found that EP rats have a decreased antioxidant enzyme activity in the brain tissue (catalase and superoxide dismutase) and blood serum (ceruloplasmin and superoxide dismutase). This antioxidant status can lead to a greater sensitivity of the EP rat brain to ethanol toxicity. The increased catalase activity in blood of EP rats reflects the elevated metabolic tolerance of this group of animals to ethanol.
Burmistrov
S O
SO
Borodkin
Iu S
IuS
D000428:Alcohol Drinking / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin
Osobennosti sostoianiia fermentov antioksidantnoĭ zashchity i urovnia perekisnogo okisleniia lipidov tkani mozga i krovi krys s raznym predpochteniem k étanolu.