The value of repeated renal retransplantations.
The outcome of 64 repeated renal retransplantations (50 third, 13 fourth, and 1 fifth) during a period of 25 years was retrospectively evaluated. The prognosis of third and subsequent grafting was greatly improved if cyclosporine was included in the induction immunosuppressive regimen (one-year graft survival 79.9%, compared with 32.4% if CsA was not used). The onset of graft function was not delayed by CsA and the proportion of never functioning grafts was significantly lower (5.3%) in patients treated with CsA than in those treated without it (43.2%). Survival of the previous grafts for longer than one year favorably influenced the outcome of the subsequent grafts.
Salmela
K
K
4th Department of Surgery, Helsinki University Central Hospital, Finland.
Kyllönen
L
L
Eklund
B
B
Isoniemi
H
H
Höckerstedt
K
K
Ahonen
J
J
D000328:Adult; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006085:Graft Survival; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D015996:Survival Rate
D003524:Cyclosporins; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens