Relationship between high density lipoprotein subfractions and coronary risk factors in a rural white population.
The relationship of serum high density lipoprotein cholesterol (HDL-C) levels and of the HDL2-C and HDL3-C subfractions to several factors associated with coronary risk was examined in a cross-sectional study, which included 655 men and 731 women ages 20 to 64 years. Participants with coronary heart disease (CHD) had lower levels of HDL-C, HDL2-C, and HDL3-C; however, only HDL-C in women was significant. Maleness, body mass index, triglyceride levels, tobacco use, and carbohydrate intake (in men) were significantly inversely related to total HDL-C, while alcohol intake was significantly positively related to HDL-C. The associations were stronger for HDL2-C than for HDL3-C, except that alcohol intake in men was more strongly related to HDL3-C. The findings of this study suggest that several factors that influence CHD risk do so in part through modifying HDL2-C levels.
Steenkamp
H J
HJ
Research Institute for Nutritional Diseases, South African Medical Research Council, Tygerberg.
Jooste
P L
PL
Benadé
A J
AJ
Langenhoven
M L
ML
Rossouw
J E
JE
D000328:Adult; D000428:Alcohol Drinking; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012424:Rural Population; D012737:Sex Factors; D012907:Smoking; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D004040:Dietary Carbohydrates; D014280:Triglycerides