[Prognostic value of thymidine kinase in cancer of the breast].
We have measured by a radioenzymatic assay the thymidine kinase in the cytosol of 182 primary infiltrating breast cancers. Maximal follow-up is 95 months. Thymidine kinase was found to be related to SBR grade, tumour size and absence of oestradiol receptors (RE). Univariate analysis has pointed out a significant linkage between overall or metastase free survival and thymidine kinase, using a cut-off level of 80 mU/mg protein which is the most discriminating value. Thymidine kinase appeared to be particularly useful in lymph-node-positive, RE-negative and grade 3 patients. Multivariate analysis of the overall survival and of the metastase free survival (Cox model) revealed that they were strongly related to thymidine kinase status.
Romain
S
S
Laboratoire d'oncologie biologique-biopathologie tissulaire, faculté de médecine de Marseille-secteur nord, France.
Javre
J L
JL
Samperez
S
S
Jouan
P
P
Bressac
C
C
Varette
I
I
Brandone
H
H
Martin
P M
PM
D001365:Axilla; D001943:Breast Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D003600:Cytosol / Q000201:enzymology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D016019:Survival Analysis; D013937:Thymidine Kinase / Q000032:analysis / Q000378:metabolism*
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D013937:Thymidine Kinase
Valeur pronostique de la thymidine kinase dans le cancer du sein.