[Medico-biological evaluation of sodium salt of nitrofurylacrylic acid as a food additive].
Nitrofurylacrylic acid sodium salt is a substance of moderate toxicity. Its LD50 for male rats after oral administration comprises 1220 mg/kg, for female rats--1400 mg/kg. The minimal toxic dose, in case of long-term administration comprises 14 mg/kg. At the level of doses from 0.04 to 4.0 mg/kg no mutagenic effect was detected. Oral and subcutaneous administration of minimal tolerance doses of the agent induced formation of malignant neoplasms developing, predominantly, from the epithelial tissue, with localization depending on the route of the agent administration. A conclusion has been made on impossibility of using this substance as a food additive.
Priputina
L S
LS
Ingre
V G
VG
Boĭko
N L
NL
Pecheniuk
E E
EE
Gulich
M P
MP
Zhil'skaia
Zh Ia
ZhIa
Opol'skiĭ
A F
AF
D000179:Acrylates / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000633:toxicity*; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D009581:Nitrofurans / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D000179:Acrylates; D005503:Food Additives; D009581:Nitrofurans; C222012:nitrofurylacrylic acid
Mediko-biologicheskaia otsenka natrievoĭ soli 5-nitrofurilakrilovoĭ kisloty kak pishchevoĭ dobavki.