Selective photoreceptor cell loss in hypoxic ischemia.
We studied the histopathologic changes in the brain and eye of a 5 1/2-month-old infant who suffered a profound hypotensive episode three days antemortem. Nuclear pyknosis and other histologic changes characteristic of ischemic cell necrosis were found throughout the brain and in the retina's photoreceptor-cell layer. These findings suggest that hypoxic ischemia may produce preferential damage to the photoreceptor-cell layer.
Holman
R E
RE
Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27599-7040.
Peiffer
R L
RL
Bouldin
T W
TW
Grimson
B S
BS
D001344:Autopsy; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D010786:Photoreceptor Cells / Q000648:ultrastructure*; D012171:Retinal Vessels / Q000648:ultrastructure*; D014057:Tomography, X-Ray Computed