title: Impact of maternal HIV infection on obstetrical and early neonatal outcome.
abstract: In a case-control study of 177 HIV-seropositive and 326 seronegative women and their newborns in Nairobi, Kenya, maternal HIV infection at term was independently associated with travel to other African countries [odds ratio (OR) 4.9, P less than 0.0001], history of a blood transfusion since 1980 (OR 3.5, P = 0.01), history of more than one sexual partner in the previous 5 years (OR 1.8, P = 0.02) and unmarried status (OR 1.8, P = 0.02). Neonates of HIV-positive and HIV-negative women differed little with respect to occurrence of congenital malformations, stillbirths, in-hospital mortality, sex, APGAR score, or gestational age. However, the mean birth weight of singleton neonates of HIV-positive women was significantly lower than that of controls (3090 versus 3220 g, P = 0.005), and birth weight was less than 2500 g in 9% of cases and 3% of controls (OR 3.0, P = 0.007). Among neonates of HIV-seropositive women, birth weight was less than 2500 g in 17% if mothers were symptomatic and 6% if mothers were asymptomatic (OR 3.4, P = 0.08).
authors: Department of Medical Microbiology, University of Nairobi, Kenya.
authors: M R
authors: MR
authors: Braddick
authors: J K
authors: JK
authors: Kreiss
authors: J B
authors: JB
authors: Embree
authors: P
authors: P
authors: Datta
authors: J O
authors: JO
authors: Ndinya-Achola
authors: H
authors: H
authors: Pamba
authors: G
authors: G
authors: Maitha
authors: P L
authors: PL
authors: Roberts
authors: T C
authors: TC
authors: Quinn
authors: K K
authors: KK
authors: Holmes
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D000013:Congenital Abnormalities; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D015658:HIV Infections / Q000503:physiopathology* / Q000635:transmission; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007630:Kenya; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology*; D011256:Pregnancy Outcome; D012307:Risk Factors