title: What's new in the mechanisms of host resistance to Candida albicans infection?
abstract: Despite extensive investigation, the mechanisms of host resistance against C. albicans infection remain poorly understood. Granulocytes and macrophages are the major effector cell types; however, their intrinsic candidacidal activity is rather limited, and its full expression requires augmentation by components of the T cell-initiated lymphokine cascade. Consequently, susceptibility to recurrent mucocutaneous infections may be associated with aberrant T cell function. In contrast, protection from systemic infection appears to be mediated by candida-specific antibodies.
authors: Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
authors: R B
authors: RB
authors: Ashman
authors: J M
authors: JM
authors: Papadimitriou
mesh_terms: D002176:Candida albicans / Q000472:pathogenicity / Q000502:physiology; D002177:Candidiasis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D012008:Recurrence; D013559:Symbiosis / Q000276:immunology