[Changes in the effects of verapamil in sensitized dogs].
The cardiovascular effects of verapamil were studied on anesthetized dogs with the intact chest, control ones and those sensitized with horse serum. Verapamil dose inducing the minimal cardio- and hemodynamic effects in the sensitized dogs was 2-3 times less that used in the controls. In addition, in contrast to the control dogs, the sensitized dogs exhibited the cardiotoxic effects of verapamil-a disorder of atrioventricular conductivity and a deterioration of the cardiac muscle relaxation. The cardiovascular effects of verapamil are modified by sensitization of the organism by heterologous serum proteins.
Shablovskaia
O V
OV
Sagach
V F
VF
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000276:immunology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D007106:Immune Sera / Q000008:administration & dosage; D007114:Immunization; D014700:Verapamil / Q000494:pharmacology*
D007106:Immune Sera; D005620:Freund's Adjuvant; D014700:Verapamil
Izmenenie éffektov verapamila u sensibilizirovannykh sobak.