[The behavior of 125I microspheres of serum albumin in the body of rabbits administered the preparation selectively into the renal artery].
Intraarterial selective injection of serum albumin microspheres into the kidney resulted in embolization of the vessels with microspheres of different sizes. In vivo radiometry made it possible to improve the localization of microspheres and their distribution in the animals' bodies at varying time of observation. Pathomorphological investigations showed optimum sizes of microspheres causing prolonged retention of microparticles at the site of injection without considerable morphological changes of body tissues. The method of using microspheres as a radionuclide carrier was shown to hold promise for therapeutic purposes.
Drozdovskiĭ
B Ia
BIa
Roziev
R A
RA
Goncharova
A Ia
AIa
Dedenkov
A N
AN
Brodskiĭ
R A
RA
Petriev
V M
VM
D000818:Animals; D004337:Drug Carriers; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D005260:Female; D007269:Injections, Intra-Arterial / Q000295:instrumentation / Q000379:methods; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007668:Kidney / Q000473:pathology / Q000528:radiation effects; D008297:Male; D008863:Microspheres; D010316:Particle Size; D011817:Rabbits; D012077:Renal Artery; D012709:Serum Albumin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D004337:Drug Carriers; D007457:Iodine Radioisotopes; D012709:Serum Albumin
Povedenie 125I-mikrosfer syvorotochnogo al'bumina v organizme krolikovv pri selektivnom vvedenii preparata v pochechnuiu arteriiu.