[Reproductive death of the apoptosis type in irradiated cells of the BW5147 thymoma].
The method of flow cytofluorometry and biochemical analysis were used to study the pattern and kinetics of the postirradiation death of proliferating BW5147 lymphoid cells. Irradiation with a dose of 10 Gy was shown to induce thymoma cell death by apoptosis. Radiation-induced synchronous transfer of part of cells from G1 to S-stage and blocking of all cells at G2/M stages of the cell cycle preceded the cell death. Decreasing of the growth factor content in a medium through its depletion or cultivation in conditions of low serum content accelerated cell death. A possible relationship between cell death and proliferation is discussed.
Kruman
I I
II
Matylevich
N P
NP
Afanas'ev
V N
VN
Umanskiĭ
S R
SR
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects*; D002588:Cesium Radioisotopes; D004273:DNA, Neoplasm / Q000528:radiation effects; D005720:Gamma Rays; D066298:In Vitro Techniques; D051379:Mice; D013945:Thymoma / Q000473:pathology*; D013953:Thymus Neoplasms / Q000473:pathology*
D002588:Cesium Radioisotopes; D004273:DNA, Neoplasm
Reproduktivnaia gibel' obluchennykh kletok timomy BW5147 po tipu apoptoza.