Excess vitamin A injures the liver.
Chronic vitamin A intoxication in a 56-year-old female is reported. Some abnormal blood chemistries included elevated transaminase and alkaline phosphatase, increased cerebrospinal fluid and portal pressure, and elevated vitamin A in blood and liver. A liver biopsy indicated histologic evidence of perisinusoidal collagen deposition and noncoalescent fat droplets in Ito cells. Caution against the misdiagnosis of alcoholic cirrhosis for vitamin A intoxication is recommended.
Baker
H
H
Department of Medicine, New Jersey Medical School, Newark.
ten Hove
W
W
Kanagasundaram
N
N
Zaki
G
G
Leevy
C B
CB
Frank
O
O
Leevy
C M
CM
D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis; D008875:Middle Aged