title: [The role of serotonin and histamine in the neurohumoral mechanisms of postirradiation diarrhea in rats].
abstract: In experiments with rats exposed to 200 Gy radiation it was shown that the diarrhea effect of serotonin under the effect of radiation is implemented via D- and M-type receptors, and that of histamine via H1 and H2 receptors. Serotonin and histamine, that were released under the effect of radiation from endocrine and mast cells of the digestive tract, stimulated the propulsion activity of the intestine whereas histamine, in addition, inhibited the absorption process. It is suggested that serotonin and histamine antagonists should be used as means of preventing of radiation-induced diarrhea.
authors: V I
authors: VI
authors: Legeza
authors: M G
authors: MG
authors: Shagoian
authors: I V
authors: IV
authors: Markovskaia
authors: T P
authors: TP
authors: Vasil'eva
authors: T D
authors: TD
authors: Pozharisskaia
authors: I I
authors: II
authors: Alekseeva
authors: O I
authors: OI
authors: Lokteva
mesh_terms: D000818:Animals; D002588:Cesium Radioisotopes; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D005720:Gamma Rays; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000627:therapeutic use; D008297:Male; D011833:Radiation Injuries, Experimental / Q000150:complications*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use
chemical_list: D002588:Cesium Radioisotopes; D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine
vernacular_title: O roli serotonina i gistamina v neĭrogumoral'nykh mekhanizmakh postluchevoĭ diarei u krys.