title: Maternal and foetal outcome of pregnant patients with sickle cell anaemia at Kenyatta National Hospital Nairobi. A retrospective study.
abstract: In a retrospective study we assessed pregnancy outcome in relation to sickle haemoglobin (HbS) and anaemia at Kenyatta National Hospital, Nairobi (KNH) from 1981-1986. There were 36% maternal and 45% foetal losses in sickle cell disease (SCD) pregnants and 7% foetal losses in sickle cell trait (HbAS) from 26 HbS-related pregnancies. 11 had homozygous sickle cell (SS) disease and 15 had HbAS. Age ranges for both groups were comparable. Mean haemoglobin-level for SS disease patients was 7.8 gm/dl (SD +/- 1.68), for AS patients 7.8 gm/dl (SD +/- 2.1). These maternal and foetal losses are quite high. Anaemia alone does not satisfactorily account for the higher losses in SS pregnancies. Other contributory factors need elucidation and intervention.
authors: Department of Internal Medicine, College of Health Sciences, University of Nairobi, Kenya.
authors: J R
authors: JR
authors: Aluoch
authors: K
authors: K
authors: Rogo
authors: M B
authors: MB
authors: Otieno
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000401:mortality / Q000628:therapy*; D005260:Female; D005313:Fetal Death; D006451:Hemoglobin, Sickle / Q000032:analysis; D006801:Humans; D007630:Kenya; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000401:mortality / Q000628:therapy*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012805:Sickle Cell Trait / Q000628:therapy
chemical_list: D006451:Hemoglobin, Sickle