title: Bay U 3405 inhibits cerebral vasospasm induced by authentic thromboxane A2.
abstract: Platelet activation results in the formation of various vasoactive mediators such as thromboxane A2 and serotonin. We investigated the effects of Bay U 3405 [(3R)-3- (4-fluorophenyl-sulfonamido)-1,2,3,4,-tetrahydro-9-carbazolepro panoic acid] on vasocontractions of isolated bovine cerebral arteries induced by U 46.619, a stable thromboxane/prostaglandin-endoperoxide analogue, and authentic thromboxane A2 released from thrombin-stimulated human platelets. Bay U 3405 (0.001-10 mumol/l) potently inhibited the contraction induced by U 46.619 and demonstrated a reduction of the thromboxane-mediated component of platelet-induced contractile response at higher concentrations (0.1-10 mumol).
authors: Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
authors: M
authors: M
authors: Braun
authors: K
authors: K
authors: Schrör
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D002227:Carbazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D002536:Cerebral Arteries / Q000187:drug effects; D006801:Humans; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000517:prevention & control*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D012701:Serotonin / Q000097:blood; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D013928:Thromboxane A2; D013931:Thromboxanes / Q000037:antagonists & inhibitors*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D002227:Carbazoles; D011450:Prostaglandin Endoperoxides, Synthetic; D013449:Sulfonamides; D013931:Thromboxanes; D012701:Serotonin; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; C063119:ramatroban