[Clinical and biochemical characterization of isoniazid-induced auto-antibodies].
Isoniazid (INH) is one among many drugs capable of inducing autoantibodies and, in some cases, a lupus-like syndrome (LE). A longitudinal study was performed in 24 tuberculosis patients treated with INH to detect antibodies (A-AH) to total histones and fractions. Antinuclear antibodies were observed in two patients after treatment. Higher frequency of IgM-AH was also observed. IgM-AH binding to all fractions were observed in those serum samples exhibiting stronger ELISA reactivity. Conversely, binding to only H1 occurred when lower IgM-AH activity was tested. Correlations with clinical expressions of LE were not observed in the present study.
Granja
C de B
Cde B
Faculdade de Medicina, Universidade de São Paulo.
Santiago
M B
MB
Viana
V S
VS
Bueno
C
C
Kumeda
C A
CA
de Oliveira
R M
RM
Cossermelli
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D015153:Blotting, Western; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006657:Histones / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007538:Isoniazid / Q000276:immunology* / Q000627:therapeutic use; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D000974:Antibodies, Antinuclear; D006657:Histones; D007075:Immunoglobulin M; D007538:Isoniazid
Caracterização clínico-laboratorial de auto-anticorpos induzidos por isoniazida.