Effect of chlorpromazine (CPZ) on the course of LCM virus infection in mice with developed and undeveloped immune system.
The cellular immune response to lymphocytic choriomeningitis (LCM) virus in germfree adult and conventional (Cv) suckling mice with undeveloped immune systems and in Cv adult mice with developed immune systems was suppressed by a single large, sublethal dose of the calmodulin antagonistic chlorpromazine and stimulated by a 100-times smaller dose administered intraperitoneally one day before the intracerebral virus infection. CPZ thus exerted a two-directional dose-dependent immunomodulatory effect in mice with both undeveloped and developed immune system.
Szeri
I
I
Institute of Microbiology, Semmelweis University Medical School, Budapest, Hungary.
Anderlik
P
P
Bános
Z
Z
Csatáry
L K
LK
Nász
I
I
Barna
Z
Z
D000818:Animals; D000833:Animals, Suckling; D002746:Chlorpromazine / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005856:Germ-Free Life; D007107:Immune System / Q000187:drug effects / Q000254:growth & development; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity; D007928:Lethal Dose 50; D008216:Lymphocytic Choriomeningitis / Q000209:etiology / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
D007166:Immunosuppressive Agents; D002746:Chlorpromazine