title: [Non-Hodgkin's malignant lymphomas in primates (immunodiagnostic principles in T-cell lymphomas)].
abstract: Morphological and immunological phenotyping was carried out on 20 cases of peripheral baboon T-cell non-Hodgkin's malignant lymphomas (NHL) observed in a Sukhumi monkey colony. Morphologically, the lymphomas were prolymphocytic, immunoblastic, or rarely lymphoblastic types. For immunophenotyping studies, the panel of 29 monoclonal antibodies (MAb) to human or mouse leukocytic antigens were used (18 CD clusters). Three polyclonal sera to human IgG and light chains kappa and lambda were also taken in experiments. The investigated NHLs and CD4+CD8- (12 cases) or CD4-CB8+ (5 cases) phenotypes. In some cases loss of pan T-cell antigens or unusual antigen expression--loss (one case) or coexpression (two cases) of T-subset antigens--or the presence of abnormal lymphoid antigens have been revealed. In most studies, baboon T-cell NHLs tumor cells belonged to activated T-cells because they expressed Ia-like antigens and IL2R at high levels. There was no correlation between the discovered immunophenotype and the morphological pattern of malignant lymphomas.
authors: L V
authors: LV
authors: Indzhiia
authors: L A
authors: LA
authors: Iakovleva
authors: M G
authors: MG
authors: Chikobava
authors: M
authors: M
authors: Valentaĭn
authors: B A
authors: BA
authors: Lapin
authors: E
authors: E
authors: Klark
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007159:Immunologic Tests; D016130:Immunophenotyping; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D010215:Papio; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II
vernacular_title: Nekhodzhkinskie zlokachestvennye limformy v otriade primatov (printsipy immunodiagnostiki T-kletochnykh limfom).