Decreased uptake and binding of 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography.
Positron emission tomography of the brain following intravenous injection of (+) (R) and (-) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of 11C-nicotine in Azheimer brains may be of diagnostic value.
Nordberg
A
A
Department of Pharmacology, University of Uppsala, Sweden.
Hartvig
P
P
Lilja
A
A
Viitanen
M
M
Amberla
K
K
Lundqvist
H
H
Andersson
Y
Y
Ulin
J
J
Winblad
B
B
Långström
B
B
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D006801:Humans; D008875:Middle Aged; D009538:Nicotine / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D009538:Nicotine