Potential toxicity of presumably insoluble aluminum salts in presence of common dietary acids.
It has recently been shown that aluminum absorption may occur following the administration of oral aluminium-containing phosphate-binders and antacids. Computer simulations based on relevant aluminium complex equilibria have been used in the present work to investigate the potential influence of the simultaneous ingestion of common dietary acids on this phenomenon. It results from these studies that aluminium absorption may be favoured to various extents in the presence of citric, malic, oxalic, succinic and tartric acids.
Dayde
S
S
INSERM U305, Université Paul Sabatier, Toulouse, France.
Berthon
G
G
D000284:Administration, Oral; D000535:Aluminum / Q000009:adverse effects* / Q000493:pharmacokinetics; D000863:Antacids / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D008954:Models, Biological
D000863:Antacids; D000535:Aluminum