[Acute diltiazem poisoning: kinetic and hemodynamics study].
The authors report three cases of diltiazem overdose with hypotension and atrio-ventricular conduction disturbances. Hemodynamic study in 2 cases showed a hyperkinetic state with a decrease of systemic vascular resistances. Diltiazem kinetics studied in 2 cases showed a plasma half life of 5.4 and 8.3 hours, a prolonged absorption until the 28th hours in one case. Treatment included gastric lavage, oral activated charcoal (2 cases), plasma expanders and in 2 cases vasopressors with alpha effects. All three patients recovered.
Jaeger
A
A
Service de Réanimation médicale et Centre Anti-Poisons, Pav. Pasteur, C.H.U., Strasbourg.
Sauder
P
P
Bianchetti
G
G
Kopferschmitt
J
J
Dahlet
M
M
Tritsch
L
L
Flesch
F
F
D000208:Acute Disease; D000328:Adult; D000368:Aged; D004110:Diltiazem / Q000493:pharmacokinetics / Q000506:poisoning*; D005260:Female; D006207:Half-Life; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D011041:Poisoning / Q000378:metabolism / Q000503:physiopathology
D004110:Diltiazem
Intoxications aiguës par le diltiazem: étude cinétique et hémodynamique.