[Efficacy and tolerance of tiaprofenic acid in acute inflammatory ORL diseases: a multicenter study of 4231 patients].
In order to evaluate effectiveness and safety of tiaprofenic acid (TA), a multicenter study involving outpatients followed by ENT specialists was carried out. Since October 1988, the trials have prospectively enrolled 4231 patients. The demography of the study's population was: 2165 male and 2066 female, mean age 39.6 +/- 15.8 years. The patients were divided into the following groups by pathology: 1281 (30.4%) otitis, 654 (15.5%) rhinosinusitis, 2178 (51.6%) pharyngo-laryngo-tonsillitis, and 112 (2.6%) flue syndrome, 300 mg b.i.d. of TA was orally administered for seven consecutive days. At T0 and T7 parameters ranged from 75-90% for symptoms related to inflammation of the oral tract, 80% for nasal edema and 100% for otalgia. The physician's judgement about the drug's effectiveness was 90.6% excellent or good. Side effects were reported in 409 cases (9.6%) mainly related to the gastrointestinal tract. There were 72 drop-out (1.7%): 38 (0.9%) for drug intolerance. In conclusion, TA showed excellent safety and effectiveness in improving the recovery of ENT's outpatients.
Pintucci
J P
JP
Divisione Otorinolaringoiatrica, Ospedale di Vimercate Milano.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy*; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid
Efficacia e tollerabilità dell'acido tiaprofenico nella patologia infiammatoria acuta ORL: studio multicentrico su 4231 pazienti.