[Effects of inmecarb on alcohol intake and the state of hepatic cytochrome P-450 system during various stages of experimental alcoholism in rats].
The influence of the new anti-alcohol drug Inmecarb on the alcohol consumption as well as on activity of the liver cytochrome P-450 system was studied in rats during chronic alcohol intoxication in the free choice situation between water and 15% ethanol solution. It was shown that voluntary alcohol consumption of different duration (10 days to 8 months) does not change the activity of liver cytochrome P-450 system. Inmecarb treatment (40 mg/kg, i.p. twice a day) during 14 days resulted in decrease of alcohol consumption in rats. This effect was most pronounced in late stages of experimental alcoholism. Inmecarb decreases the cytochrome P-450 content and suppresses the activity of aniline hydroxylase in rats with different duration of voluntary alcohol intoxication, but most pronounced effect was observed during the late stages of experimental alcoholism.
Khlopushina
G T
GT
Kashevskaia
O P
OP
Kampov-Polevoĭ
A B
AB
D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013997:Time Factors
D001593:Benzyl Compounds; D007211:Indoles; C055071:inmecarb; D003577:Cytochrome P-450 Enzyme System
Vliianie inmekarba na potreblenie alkogolia i na sostoianie sistemy tsitokhroma P-450 pecheni na raznykh stadiiakh éksperimental'nogo alkogolizma u krys.