Screening of antibiotics preferentially active against ras oncogene-expressed cells.
During the course of in vitro screening of agents which are preferentially active against ras oncogene-expressed cells, a new anthracycline (identified as 2-demethylsteffimycin D) and a heptaene (possibly a new member of partricins) were isolated from microbial fermentation broths. Among known compounds tested, 5-fluorouracil, 5-fluorodeoxyuridine and oxanosine showed high selectivity towards ras oncogene-expressed cells.
Suzukake-Tsuchiya
K
K
Showa College of Pharmaceutical Sciences, Machida city, Tokyo, Japan.
Moriya
Y
Y
Yamazaki
K
K
Hori
M
M
Hosokawa
N
N
Sawa
T
T
Iinuma
H
H
Naganawa
H
H
Imada
C
C
Hamada
M
M
D000818:Animals; D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002461:Cell Line, Transformed; D002851:Chromatography, High Pressure Liquid; D015972:Gene Expression Regulation, Neoplastic; D011905:Genes, ras; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D011090:Polyenes; C100293:partricin; C066805:2-demethylsteffimycin D; C009944:steffimycin