Cerebellar syndrome caused by isoniazid.
Treatment of tuberculosis in a hemodialysis patient with isoniazid, rifampin, and pyrazinamide resulted in the development of acute cerebellar dysfunction. This resolved rapidly following the discontinuation of isoniazid and pyrazinamide, reinstitution of isoniazid at a lower dose, and addition of pyridoxine. We discuss why we believe this syndrome was caused by isoniazid. Patients with renal failure who undergo antituberculous therapy with isoniazid should receive supplemental pyridoxine to reduce the likelihood of isoniazid-related neurotoxicity.
Blumberg
E A
EA
School of Medicine, Hahnemann University, Philadelphia, PA 19102.
Gil
R A
RA
D000368:Aged; D002526:Cerebellar Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000628:therapy; D011718:Pyrazinamide / Q000009:adverse effects / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use; D006435:Renal Dialysis; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy
D011718:Pyrazinamide; D011736:Pyridoxine; D007538:Isoniazid