The effect of cholestyramine and activated charcoal on glipizide absorption.
1. The interference of cholestyramine and activated charcoal with the absorption of glipizide was studied. 2. In a cross-over study comprising three phases, single doses of cholestyramine (8 g), activated charcoal (8 g) or water only were given to six healthy volunteers together with a single dose of glipizide. 3. The absorption of glipizide was moderately (29%, P less than 0.01) reduced by cholestyramine and greatly reduced (81%, P less than 0.01) by activated charcoal. 4. If cholestyramine and glipizide are used concomitantly, glipizide should be taken 1-2 h beforehand. In acute glipizide overdosage, activated charcoal can be used to reduce absorption.
Kivistö
K T
KT
Department of Pharmacology, University of Turku, Finland.
Neuvonen
P J
PJ
D000042:Absorption / Q000187:drug effects; D000328:Adult; D002606:Charcoal / Q000494:pharmacology*; D002792:Cholestyramine Resin / Q000494:pharmacology*; D005913:Glipizide / Q000097:blood / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D008297:Male
D002792:Cholestyramine Resin; D002606:Charcoal; D005913:Glipizide