Isolation, synthesis, and evaluation of a series of indencarbazates as hypotensive agents.
Two indencarbazates, 1 and 2, were isolated from the sponge Cliona caribboea. These compounds were found to possess mild hypotensive activity. A series of analogues of 1 was synthesized in order to study the structure-activity relationship of this unique class of compounds. A variety of structural changes did not result in a consistent pattern of biological activity.
Lemke
T L
TL
Department of Medicinal Chemistry and Pharmacognosy, University of Houston, College of Pharmacy, TX 77204-5515.
Sanduja
R
R
Mroue
M M
MM
Iyer
S
S
Alam
M
M
Hossain
M B
MB
van der Helm
D
D
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D051381:Rats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D006834:Hydrazines; D007192:Indenes; C066937:caribbazoin A; C066938:caribbazoin B