[Mitotic effect of the pigment epithelium].
The authors suggest the production by the cultured RPE cell of one or more angiogenic substances. This activity is highly increased when RPE are cultured in poor conditions, either due to a poor medium or after having been challenged by a high number of rod outer segments. The mitotic factor appears heat-labile and trypsine sensitive, but not dialysable which suggest their biochemical nature to be a protein.
Smets
R M
RM
Institut d'Ophthalmologie Expérimentale de l'Université d'Anvers, UIA, Wilrijk, Belgique.
Yang
Q R
QR
Neetens
A
A
Vanden Berghe
D
D
D000368:Aged; D002450:Cell Communication / Q000502:physiology; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D008938:Mitosis / Q000502:physiology*; D010857:Pigment Epithelium of Eye / Q000378:metabolism*
D006133:Growth Substances
Effet mitotique de l'épithélium pigmentaire.