title: Monte Carlo methods of neutron beam design for neutron capture therapy at the MIT Research Reactor (MITR-II).
abstract: Monte Carlo methods of coupled neutron/photon transport are being used in the design of filtered beams for Neutron Capture Therapy (NCT). This method of beam analysis provides segregation of each individual dose component, and thereby facilitates beam optimization. The Monte Carlo method is discussed in some detail in relation to NCT epithermal beam design. Ideal neutron beams (i.e., plane-wave monoenergetic neutron beams with no primary gamma-ray contamination) have been modeled both for comparison and to establish target conditions for a practical NCT epithermal beam design. Detailed models of the 5 MWt Massachusetts Institute of Technology Research Reactor (MITR-II) together with a polyethylene head phantom have been used to characterize approximately 100 beam filter and moderator configurations. Using the Monte Carlo methodology of beam design and benchmarking/calibrating our computations with measurements, has resulted in an epithermal beam design which is useful for therapy of deep-seated brain tumors. This beam is predicted to be capable of delivering a dose of 2000 RBE-cGy (cJ/kg) to a therapeutic advantage depth of 5.7 cm in polyethylene assuming 30 micrograms/g 10B in tumor with a ten-to-one tumor-to-blood ratio, and a beam diameter of 18.4 cm. The advantage ratio (AR) is predicted to be 2.2 with a total irradiation time of approximately 80 minutes. Further optimization work on the MITR-II epithermal beams is expected to improve the available beams.
authors: Nuclear Reactor Laboratory, Massachusetts Institute of Technology, Cambridge.
authors: S D
authors: SD
authors: Clement
authors: J R
authors: JR
authors: Choi
authors: R G
authors: RG
authors: Zamenhof
authors: J C
authors: JC
authors: Yanch
authors: O K
authors: OK
authors: Harling
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy; D005160:Facility Design and Construction; D006801:Humans; D008961:Models, Structural; D009010:Monte Carlo Method; D009502:Neutrons / Q000627:therapeutic use*; D009688:Nuclear Reactors / Q000295:instrumentation*; D011827:Radiation