Enhanced lung colonization and tumorigenicity of fused cells isolated from primary MCA tumors.
Cells derived from cell-cell fusion events were clonally isolated from primary methylcholanthrene (MCA)-induced tumors in allophenic mice. Compared with non-fused cells isolated from the same cultures, the fused cells had markedly greater experimental metastasizing (lung colonizing) activity, but only slightly greater tumorigenicity and the same cloning efficiency in soft agar. Cell-cell fusion may thus contribute to the generation of tumor heterogeneity that underlies the process of tumor progression.
Fortuna
M B
MB
Laboratory of Cell Biology, AMC Cancer Research Center, Denver, CO 80214.
Dewey
M J
MJ
Furmanski
P
P
D000818:Animals; D002459:Cell Fusion / Q000502:physiology; D002999:Clone Cells / Q000166:cytology; D005956:Glucose-6-Phosphate Isomerase / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary*; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis / Q000235:genetics*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured
D008748:Methylcholanthrene; D005956:Glucose-6-Phosphate Isomerase