title: Electrophysiological properties of frog spinal dorsal horn neurons and their responses to serotonin: an intracellular study in the isolated hemisected spinal cord.
abstract: Frog dorsal horn neurons and their responses to serotonin (5-HT) were studied in intracellular recordings from isolated hemisected spinal cords. Electrophysiological properties were comparable to those of mammals. Bath application of 5-HT (10-50 microM) increased the excitability and caused membrane depolarizations in 7/14 cells, reduced or abolished activity and caused hyperpolarizations in 4 neurons, exerted a biphasic effect in two cells, and produced no detectable change in one neuron. The multiple effects of 5-HT may be mediated through different 5-HT receptor subtypes.
authors: Department of Comparative Biosciences, University of Wisconsin, Madison 53706.
authors: H J
authors: HJ
authors: Tan
authors: V
authors: V
authors: Miletic
mesh_terms: D000818:Animals; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011894:Rana pipiens; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*
chemical_list: D012701:Serotonin