title: Moclobemide versus placebo in the treatment of depression: a multicentre study in Belgium.
abstract: Moclobemide was compared with placebo for antidepressant activity, tolerance and safety in 2 parallel groups of 23 and 24 depressed patients. At the end of treatment (4 weeks or longer), 9 patients on moclobemide (41%) showed an improvement greater than or equal to 50% on the Hamilton Rating Scale for Depression, compared with only 4 (17%) of those on placebo. The overall assessment of efficacy was significantly better for moclobemide (good or very good results in 50% of patients) than for placebo (80% poor results). Moclobemide was well or very well tolerated by 85% of patients and placebo by 100%. Moclobemide was thus shown to be clearly more effective than placebo and only slightly less well tolerated.
authors: Centre Hospitalier de Tivoli, La Louvière, Belgium.
authors: L
authors: L
authors: Botte
authors: C
authors: C
authors: Gilles
authors: J L
authors: JL
authors: Evrard
authors: P
authors: P
authors: Mesters
authors: C
authors: C
authors: Wolfrum
authors: M
authors: M
authors: Berger
authors: K
authors: K
authors: Hellstern
authors: J
authors: J
authors: Ward
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001530:Belgium; D001549:Benzamides / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide