title: Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome.
abstract: Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (MO) functions, depressed immune functions, and poor clinical outcome. The trauma patients' FcRI+ MO subpopulation produced the majority of their elevated IL-6, TNF alpha, TGF beta, and PGE2. IgG stimulation of patients' MO through FcRI not only stimulated TNF alpha, IL-6, and PGE2 levels, but also greatly augmented the levels of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal B-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FcRI on the increased numbers of FcRI+ MO leading to ever-increasing monokine levels. IL-4 was found to downregulate patients' FcRI+ MO production of mediators. The cycle of altered cytokine levels, increased FcRI+ MO numbers, elevated IgG, and augmented triggering of FcRI+ MO may be broken by addition of IL-4.
authors: Department of Surgery, Univ. of Massachusetts Medical Center, Worcester 01655.
authors: C L
authors: CL
authors: Miller-Graziano
authors: G
authors: G
authors: Szabo
authors: K
authors: K
authors: Kodys
authors: K
authors: K
authors: Griffey
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000276:immunology* / Q000378:metabolism; D002469:Cell Separation; D006801:Humans; D007108:Immune Tolerance; D007213:Indomethacin / Q000276:immunology; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D012397:Rosette Formation; D012772:Shock, Septic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D011458:Prostaglandins E; D014409:Tumor Necrosis Factor-alpha; D007213:Indomethacin