[Genetic variants of haptoglobin in patients with destructive pulmonary tuberculosis].
Haptoglobin (Hb) phenotyping was carried out in 143 patients with tuberculosis and 221 practically healthy persons. Three phenotypes were distinguished: two homozygotic Hp. 1:1 and Hp. 2:2 and one heterozygotic Hp. 2:1. An analysis of the frequency of distribution of the above-mentioned phenotypes indicates that patients with tuberculosis as compared with the healthy showed a significant reduction of the number of Hp. 2:1 carriers while the number of Hp. 2:2 increased. There was a definite dependence between the haptoglobin phenotype and course of the disease. In carriers of the Hp. 2:1 abacillation of the sputum and closure of destructions occurred earlier than in carriers of Hp 1:1 and, in particular, Hp. 2:2.
Kharakter
Zh Z
ZhZ
Mazhak
K D
KD
Pavlenko
A V
AV
Kapral'AIa
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006242:Haptoglobins / Q000032:analysis / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000382:microbiology; D014455:Ukraine
D006242:Haptoglobins
Geneticheskie varianty gaptoglobina u bol'nykh destruktivnym tuberkulezom legkikh.