Inhibition of [3H]glutamate release by Zn2+ in rat hippocampal slices.
Zn2+ at the concentration of 10 microM inhibited the depolarization-induced [3H]glutamate release from the preloaded rat hippocampal slices both in the presence and absence of Ca2+ without affecting [3H]GABA and [3H]ACh release. Of divalent cations tested, Zn2+ and Fe2+ had an inhibitory effect on the release of glutamate.
Kihara
T
T
Laboratory of Molecular pharmacology, Suntory Institute for Biomedical Research, Osaka Japan.
Baba
A
A
Koyama
Y
Y
Ishihara
T
T
Iwata
H
H
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D009532:Nickel / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium; D015032:Zinc / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D002413:Cations, Divalent; D005971:Glutamates; D014316:Tritium; D003035:Cobalt; D005680:gamma-Aminobutyric Acid; D009532:Nickel; D015032:Zinc; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium