title: Antiallergic and anti-inflammatory action of tioxamast in rats. II. Anti-inflammatory action in vivo.
abstract: Tioxamast is an antiallergic drug that inhibits anaphylaxis in various models in rats, and it inhibits the release and synthesis of certain mediators of inflammation [see Tarayre et al., this issue]. Here we report that the drug also has an anti-inflammatory effect in vivo in various nonimmunological models in rats. It reduces zymosan-induced inflammation in the paw and pleural cavity, starting at doses from 1.5625 to 3.125 mg/kg given intraperitoneally. In pleurisy, tioxamast lowers the concentration of leukotriene B4 (LTB4) in the exudate, at doses from 50 mg/kg i.p. Also, at doses from 12.5 mg/kg i.p., the compound reduced PAF-acether-induced pleurisy and the concentrations of LTB4 and peptidoleukotrienes in the exudate. An anti-inflammatory action against carrageenin-induced edema of the paw was seen only at doses of 50 mg/kg i.p. or more. The anti-inflammatory and antiallergic effect of tioxamast makes it a potentially useful drug in the treatment of allergies in humans.
authors: Department of Pharmacology A, P. Fabre Research Center, Castres, France.
authors: J P
authors: JP
authors: Tarayre
authors: M
authors: M
authors: Aliaga
authors: M
authors: M
authors: Barbara
authors: N
authors: N
authors: Tisseyre
authors: V
authors: V
authors: Caillol
authors: A
authors: A
authors: Delhon
authors: F
authors: F
authors: Bruniquel
authors: X
authors: X
authors: N'Guyen
authors: L
authors: L
authors: Puech
authors: J
authors: J
authors: Tisné-Versailles
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy; D006633:Histamine Antagonists / Q000494:pharmacology*; D008297:Male; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D010998:Pleurisy / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D015054:Zymosan / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D010972:Platelet Activating Factor; D015054:Zymosan; C037054:tioxamast; D010072:Oxamic Acid