title: Spermatocytic seminoma associated with rhabdomyosarcoma.
abstract: A case of spermatocytic seminoma intimately associated with rhabdomyosarcoma is reported. The patient, a 51-year-old man, presented with a two-year history of right-sided testicular enlargement. Orchiectomy was performed, and a large testicular tumor was excised. Further investigations during hospitalization revealed lung, liver, and retroperitoneal lymph node metastases. Further therapy was refused, and the patient died at home two months after orchiectomy. Autopsy was not permitted. Although the great majority of spermatocytic seminomas occur in pure form, do not metastasize, and have very good prognosis, in addition to the present case, seven cases of spermatocytic seminoma associated either with rhabdomyosarcoma or undifferentiated sarcoma have been reported. Presence of the sarcomatous element is associated with aggressive behavior, metastatic disease, and very poor prognosis. It is considered that the sarcomatous element develops from the spermatocytic seminoma by anaplastic transformation.
authors: Department of Pathology, Cancer Research Institute, Bratislava, Czechoslovakia.
authors: J
authors: J
authors: Matoska
authors: A
authors: A
authors: Talerman
mesh_terms: D004407:Dysgerminoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000648:ultrastructure; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000648:ultrastructure; D013736:Testicular Neoplasms / Q000473:pathology* / Q000648:ultrastructure