title: Pathogenesis and treatment of intra-abdominal infection.
abstract: Intra-abdominal infection is considered potentially life-threatening. Such infection is frequently secondary to perforated viscera, trauma or inflammatory disease. Simple abscesses may be drained percutaneously with roentgenologic guidance; complex abscesses often require open surgical drainage. Secondary peritonitis is usually polymicrobial; broad-spectrum antimicrobial therapy effective against aerobic and anaerobic gram-negative bacteria, as well as gram-positive organisms, is essential. Newer antibiotics, administered either singly or in combination, have been used successfully to treat intra-abdominal infection while avoiding the toxicity of aminoglycosides.
authors: Department of Surgery, Metro Health Medical Center, Case Western Reserve University, Cleveland, Ohio 14109.
authors: M A
authors: MA
authors: Malangoni
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004322:Drainage; D004359:Drug Therapy, Combination; D006801:Humans; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents