[Histocompatibility antigens and acute vascular purpura].
BACKGROUND
Some kidney diseases are associated to HLA antigens. Nyulassy found an increase in HLA-B35 in patients with Henoch-Schönlein's purpura suffering nephritis (HSP-N). Our study searched for associations of HLA antigens and anaphylactoid purpura nephritis in Mexican mestizo patients.


METHODS
HLA-A,B, and C antigens were detected by two-step microcytotoxicity in 22 patients with HSP-N and compared to those of 665 healthy subjects of the same ethnic background.


RESULTS
A significant association was found between HSP-N and HLA-Aw19 single (pc less than 0.05) or in haplotype form (Aw19-B35) (pc less than 0.005). HLA B35 alone was associated to HSP-N but only at non corrected level (pc less than 0.05).


CONCLUSIONS
The significant association between HLA-Aw19 and Aw19-B35 and HSP-N may indicate a risk factor in Mexican mestizo patients to develop this case.
Arellano
J
J
División de Inmunología, Unidad de Investigación Biomédica, Centro Médico Nacional, Instituto Mexicano del Seguro Social, D.F.
Ojeda
S
S
Vargas
R
R
Zavala
C
C
Santos
D
D
López
A
A
Kretschmer
R
R
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000208:ethnology; D008297:Male; D008800:Mexico
D006680:HLA Antigens
Antígenos de histocompatibilidad y púrpura vascular aguda.