Brain amino acid contents are dissimilar in sporadic and Guamanian amyotrophic lateral sclerosis.
Amino acid contents were measured in autopsied brains of five Guamanian patients with amyotrophic lateral sclerosis (ALS) or parkinsonism-dementia. Absence of the glutamate deficiency and taurine excess characteristic of sporadic ALS suggest that, despite clinical similarities, Guamanian ALS is a different disorder from sporadic ALS.
Perry
T L
TL
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
Bergeron
C
C
Steele
J C
JC
McLachlan
D R
DR
Hansen
S
S
D000368:Aged; D000596:Amino Acids / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000378:metabolism; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D013654:Taurine; D005680:gamma-Aminobutyric Acid