[Genoregulatory mechanisms of aging as a basis for the development of age-related pathology].
The development of age pathology has been studied in relation to changes occurring in the activity of various genes and in the synthesis of various proteins as well as in relation to the topography of those changes. The relationship between age-related changes in the activity of various genes and the onset of atherosclerosis, cancer, diabetes, Parkinson's disease and Alzheimer's disease has been studied. The appearance of gene regulatory age-related changes in cells of the nervous, endocrine and immune systems determines their involvement in the age pathology development. The prospects of gene regulatory therapy aimed at selective activation and suppression of various gene groups are outlined.
Frol'kis
V V
VV
Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev.
D000222:Adaptation, Physiological / Q000502:physiology; D000375:Aging / Q000235:genetics* / Q000473:pathology; D000818:Animals; D004700:Endocrine System Diseases / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000473:pathology; D009422:Nervous System Diseases / Q000235:genetics; D014176:Protein Biosynthesis
Genoreguliatornye mekhanizmy stareniia--osnova razvitiia vozrastnoĭ patologii.