Short-term therapy of atherosclerosis with low dose indomethacin: an experimental study.
The effects of low dose indomethacin therapy in primary prevention of diet-induced atherosclerosis of rhesus monkeys was studied. The parameters studied were serum cholesterol concentration, thromboxane A2 (T x B2), prostacyclin (6-keto-PGF1 alpha) in serum/plasma, and the extent and intensity of coronary atherosclerosis. Although indomethacin did not affect serum cholesterol, it reduced serum T x B2 significantly (P less than 0.01). Plasma 6-keto-PGF1 alpha was not restored to the pretreatment level. A significant protective role of the drug was noted as far as coronary atherosclerosis is concerned (P less than 0.01).
Dhawan
V
V
Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ganguly
N K
NK
Majumdar
S
S
Chakravarti
R N
RN
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D007213:Indomethacin / Q000627:therapeutic use*; D008253:Macaca mulatta; D008297:Male; D013928:Thromboxane A2 / Q000097:blood
D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D002784:Cholesterol; D007213:Indomethacin