Pivampicillin/pivmecillinam in the treatment of shigella carriers.
24 patients (4-65 years old; median age 29 years) excreting shigella bacteria greater than 8 weeks were treated with the combination pivampicillin (0.25 g)/pivmecillinam (0.20 g), 2 tablets 3 times a day for 14 days. 23/24 patients (96%) were culture negative after treatment. The one patient that did not respond to treatment carried a strain with intermediate sensitivity to mecillinam and resistance to ampicillin. It is concluded that pivampicillin/pivmecillinam is effective for patients excreting shigella bacteria.
Ekwall
E
E
Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institute, Stockholm, Sweden.
Svenungsson
B
B
D000293:Adolescent; D000328:Adult; D000560:Amdinocillin / Q000494:pharmacology; D000561:Amdinocillin Pivoxil / Q000494:pharmacology / Q000627:therapeutic use*; D000667:Ampicillin / Q000494:pharmacology; D000668:Ampicillin Resistance; D002353:Carrier State / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010917:Pivampicillin / Q000494:pharmacology / Q000627:therapeutic use*; D012760:Shigella / Q000187:drug effects
D004338:Drug Combinations; D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D000560:Amdinocillin