title: Secretory patterns of growth hormone according to sex and age.
abstract: Gender and age have distinct and interrelated effects on GH secretion in adults. GH secretion falls significantly with aging, particularly in women. The fall in GH release is amplitude- rather than frequency-modulated and appears to be related to estrogen status. Oral estrogen administration is unphysiological and causes a marked perturbation of the GH/insulin-like growth factor I axis. A nonparenteral route of administration is required for further investigations of the physiological role of estrogen in GH secretion.
authors: Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia.
authors: K Y
authors: KY
authors: Ho
authors: A J
authors: AJ
authors: Weissberger
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002940:Circadian Rhythm; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008099:Liver / Q000187:drug effects; D008297:Male; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D012737:Sex Factors; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004997:Ethinyl Estradiol; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone