A randomized trial comparing whole abdominal radiotherapy with chemotherapy following cisplatinum cytoreduction in epithelial ovarian cancer. West Midlands Ovarian Cancer Group Trial II.
The potential role of consolidation therapy has been tested in a randomized trial in ovarian cancer. Patients were randomized to receive either whole abdominal radiotherapy using the moving strip technique (n = 56) or one year of chlorambucil (n = 53) following primary surgery, five courses of cisplatinum 100 mg/m2, and second look laparotomy. Overall survival at two years was 35%. There was no significant difference in survival between the two groups, and in spite of the observation that approximately 50% of the patients were optimally debulked prior to consolidation, no subgroups in either arm could be identified who might benefit from consolidation therapy. Toxicity was considerable in both arms, and almost 50% of patients were unable to complete the planned treatment in both arms. These results suggest that after primary surgery and cisplatinum chemotherapy, there is no indication for consolidation therapy with either radiotherapy or alkylating agents.
Lawton
F
F
West Midlands Ovarian Cancer Group, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, UK.
Luesley
D
D
Blackledge
G
G
Hilton
C
C
Kelly
K
K
Latief
T
T
Mould
J
J
Spooner
D
D
Rollason
T
T
Wade-Evans
T
T
D000005:Abdomen / Q000528:radiation effects; D002699:Chlorambucil / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008722:Methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D011446:Prospective Studies; D012086:Reoperation; D015996:Survival Rate
D002699:Chlorambucil; D002945:Cisplatin