Suxamethonium--electromyographic studies in children.
Suxamethonium was administered to 225 children aged from one to sixteen years, in doses varying from 0.1 to 0.5 mg/kg. Dose responses were determined. ED95 was 445 micrograms/kg in one to four year olds, 454 micrograms/kg in the five to ten years group and 270 micrograms/kg in eleven to fifteen year olds (P less than 0.05). There is a wider variability in patient responses to 0.1 and 0.2 mg/kg than to the higher doses. Sixty-two children in the three age groups were given suxamethonium 1 mg/kg. The time from injection to maximum block and to 50% recovery increased with increasing age (P less than 0.05).
Brown
T C
TC
Department of Anaesthesia, Royal Children's Hospital, Melbourne, Victoria, Australia.
Meretoja
O A
OA
Bell
B
B
Clare
D
D
D000293:Adolescent; D000375:Aging; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D006801:Humans; D007223:Infant; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D012044:Regression Analysis; D013390:Succinylcholine / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D013390:Succinylcholine