title: Effect of perinatal lead exposure on morphine tolerance in the neonatal rat.
abstract: Administration of lead (at 300 and 1000 ppm) in the maternal drinking water from conception to postnatal day 10 increased the sensitivity of 10-day rat pups to noxious stimuli and disrupted the dose-response relationship to morphine antinociception. Lead-exposed rats could be made tolerant to morphine over a 5-day period (twice daily injections of 5 mg/kg morphine, postnatal days 5-10) and antinociceptive responses in tolerant rats were also disrupted by lead exposure.
authors: Department of Biochemistry, University of Surrey, Guildford, U.K.
authors: I
authors: I
authors: Kitchen
authors: J A
authors: JA
authors: Boswell
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008431:Maternal-Fetal Exchange; D009021:Morphine Dependence / Q000209:etiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007854:Lead