title: The ontogeny of feline temporal lobe epilepsy: kindling a spontaneous seizure disorder in kittens.
abstract: We describe the ontogeny of feline temporal lobe epilepsy after amygdala kindling in 24 cats, aged 2.5 months to over 1 year. In so doing, we report the first experimental model of spontaneous epilepsy in immature animals. Preadolescent kittens (n = 12 less than or equal to 6.5 months) are far more likely to develop epilepsy, indexed by spontaneous seizures, than are adult cats (n = 12 greater than 1 year). Moreover, youth accelerated the development of epilepsy. The younger the kitten at the beginning of kindling, the more probable and rapid the onset of spontaneous seizures. Failed postictal depression was the most reliable precursor of spontaneous seizures in immature cats. However, spontaneous epilepsy continued after postictal refractory periods stabilized and was still present when kittens matured to adulthood. Collectively, the results suggest that failed inhibition contributes to the onset of spontaneous epilepsy in immature animals but that other morphologic, physiological and/or chemical changes might sustain epilepsy afterwards.
authors: Department of Anatomy and Cell Biology, UCLA School of Medicine 90024.
authors: M N
authors: MN
authors: Shouse
authors: A
authors: A
authors: King
authors: J
authors: J
authors: Langer
authors: T
authors: T
authors: Vreeken
authors: K
authors: K
authors: King
authors: M
authors: M
authors: Richkind
mesh_terms: D000375:Aging; D000679:Amygdala / Q000254:growth & development / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002415:Cats; D004558:Electric Stimulation; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D012890:Sleep; D014851:Wakefulness