Gastrointestinal tumours after stapler vs vicryl anastomoses in carcinogen-treated rats.
Since nickel is a potent carcinogen the influence of nickel-containing staples on the frequency of gastrointestinal tumour formation was tested in caecum-resected and carcinogen-treated rats. Tumour formation was elevated after stapling compared with simple laparotomy or vicryl sutures. This demonstrates a potential hazard of stapling techniques. In the vicryl group there was only one suture line carcinoma.
Buhr
H J
HJ
Department of Surgery, University of Heidelberg, FRG.
Hupp
T
T
Beck
N
N
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced / Q000601:surgery*; D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000601:surgery*; D004127:Dimethylhydrazines; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009532:Nickel / Q000009:adverse effects*; D011098:Polyglactin 910; D051381:Rats; D013528:Surgical Staplers; D013536:Suture Techniques; D013537:Sutures
D002273:Carcinogens; D004127:Dimethylhydrazines; D011098:Polyglactin 910; D009532:Nickel; D019813:1,2-Dimethylhydrazine