In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.
Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/Salmonella assay both with and without S9 did not show an increase in the His+ revertants.
Bali
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Department of Human Biology and Human Genetics, Guru Nanak Dev University, Amritsar, India.
Singh
J R
JR
Singh
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Sandhu
D
D
D000328:Adult; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D006854:Hydrocortisone / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange
D009153:Mutagens; D006854:Hydrocortisone