Calbindin D28k-containing splanchnic and cutaneous dorsal root ganglion neurons of the rat.
Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanchnic sensory neurons were immunoreactive to CaBP, while only 3% of the cutaneous sensory neurons were. The diameters of the splanchnic and cutaneous sensory neurons containing CaBP were 23.4 +/- 6.3 microns and 38.4 +/- 8.8 microns, respectively. Splanchnic sensory neurons containing CaBP were sensitive to capsaicin while cutaneous ones were not. These findings suggest that CaBP-containing splanchnic and cutaneous sensory neurons constitute different subgroups among the DRG neurons at the lower thoracic level.
Kashiba
H
H
Department of Physiology, Kansai College of Acupuncture Medicine, Osaka, Japan.
Senba
E
E
Ueda
Y
Y
Tohyama
M
M
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D005727:Ganglia, Spinal / Q000737:chemistry* / Q000166:cytology; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009475:Neurons, Afferent / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D012867:Skin / Q000294:innervation*; D013153:Splanchnic Nerves / Q000737:chemistry*
C576500:Calb1 protein, rat; D064092:Calbindin 1; D064026:Calbindins; D009419:Nerve Tissue Proteins; D064030:S100 Calcium Binding Protein G