Congenital ptosis in monozygotic twins.
A case of concordance for unilateral congenital ptosis in monozygotic twins is presented. The literature on genetics and congenital ptosis is reviewed. A heritability index is calculated for congenital ptosis, based on all current twin data including the present report. A value for the heritability index of 0.75 is found, suggesting a strong hereditary influence for congenital ptosis. We conclude that twin data strongly support a transmissable genetic defect as contributing to the development of congenital ptosis.
Vestal
K P
KP
Department of Ophthalmology, University of California, San Francisco.
Seiff
S R
SR
Lahey
J M
JM
D000328:Adult; D001763:Blepharoptosis / Q000151:congenital / Q000235:genetics* / Q000601:surgery; D004200:Diseases in Twins; D006801:Humans; D008297:Male; D008722:Methods; D014430:Twins, Monozygotic