[Therapeutic high-doses of digoxin with blood level determinations in 31 out of 150 elderly hospitalized patients treated over a year].
The assay by immunoenzymatic method of the blood level of digoxine in 150 old people, (m = 79 years), hospitalized during one year shows a level of more than 2 ng/ml in 31 of them, (m = 2.91 ng/ml). However, the dosage is normal or low, m = 0.206 mg/j. A renal impairment often discussed is not the mechanism: 17 patients with a blood creatinine over 135 mumol/l have a mean blood level of digoxine of 2.98 ng/ml for 2.91 in the 14 another ones without renal impairment. Physicians should be still more cautious when prescribing digoxin.
Bellamy
C
C
Centre Anti-Poisons, Hôpital Fernand Widal, Paris.
Castot
A
A
Arsac
P
P
Efthymiou
M L
ML
D000368:Aged; D000369:Aged, 80 and over; D004077:Digoxin / Q000009:adverse effects / Q000097:blood*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D004077:Digoxin
Surdosages thérapeutiques en digoxine contrôlés biologiquement chez 31 malades âgés sur 150 sujets traités en un an.