Interactions of selenium and fluoride on growth, glycolysis and survival of Streptococcus mutans GS-5.
The effects of low concentrations (1.0 mmol/l of selenite and seleno-dl-cystine were tested alone, or in combination with NaF, on growth, glycolysis, and survival of Streptococcus mutans GS-5. In batch culture, both selenium-containing compounds (1.0 mmol/l) inhibited the growth rate and final cell yield by 92% or greater; glycolysis, however, was not affected. The observed bactericidal action of selenite at 0.1 mmol/l was pH-dependent. Fluoride reduced the killing effect of SeO3 in the culture medium and in a lactate-acetate buffer system at pH 6.5, 5.0 and 4.0. These data indicate that selenium-containing compounds exert an antibacterial action on cells of S. mutans in a manner which leaves glycolysis unaffected.
Eisenberg
A D
AD
Eastman Dental Center, Rochester, NY.
Curzon
M E
ME
Izaguirre-Fernàndez
E J
EJ
D000818:Animals; D015169:Colony Count, Microbial; D003553:Cystine / Q000031:analogs & derivatives / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology; D004347:Drug Interactions; D005459:Fluorides / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D016566:Organoselenium Compounds; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000378:metabolism
D016566:Organoselenium Compounds; C009226:selenocystine; D003553:Cystine; D020887:Selenious Acid; D012643:Selenium; D005459:Fluorides