P300 and smooth eye pursuit: concordance of abnormalities and relation to clinical features in DSM-III schizophrenia.
Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group differences were found for P300 amplitudes, latencies and eye-tracking. A family history of psychiatric illness was associated with normal eye-tracking in patients. Small P300 amplitudes alone and in combination with long P300 latencies were associated with a family history in controls.
Ebmeier
K P
KP
Department of Mental Health, University of Aberdeen, United Kingdom.
Potter
D D
DD
Cochrane
R H
RH
Mackenzie
A R
AR
MacAllister
H
H
Besson
J A
JA
Salzen
E A
EA
D000328:Adult; D001143:Arousal / Q000235:genetics; D001288:Attention / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation; D005072:Evoked Potentials, Auditory / Q000235:genetics; D005073:Evoked Potentials, Somatosensory / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011698:Pursuit, Smooth / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation
D005819:Genetic Markers