The magnetocardiogram as derived from electrocardiographic data.
Magnetocardiographic signals, as present outside the thorax and generated by the depolarization process within the ventricles of the human heart, have been computed by using a model that incorporates the uniform double layer as the exclusive primary source. The volume conductor effects are treated by using an inhomogeneous, multicompartmental model of the thorax, based on "tailored" geometry derived from magnetic resonance imaging. The required activation function, specifying the timing of the ventricular depolarization process, was derived from an inverse procedure that uses as input data electric signals measured at the body surface. Next, the magnetic signals from the same subjects were measured. A close correspondence between computed and measured magnetic signals was observed (relative root mean square residual difference of 0.37). These results demonstrate that magnetocardiograms and electrocardiograms have a common basis and that it is unlikely that prominent sources exist that are electrically silent and yet active in the genesis of the magnetic fields associated with the depolarization process of the heart. Moreover, fresh support is implied for the usefulness of the classical uniform double layer as the electrical source model during ventricular depolarization. The contributions of the secondary sources have previously been found to be a major component of the electric signals; they are now also shown to be a major component of the magnetic signals.
van Oosterom
A
A
Laboratory of Medical Physics and Biophysics, University of Nijmegen, The Netherlands.
Oostendorp
T F
TF
Huiskamp
G J
GJ
ter Brake
H J
HJ
D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006801:Humans; D008280:Magnetics; D008954:Models, Biological