Responses to small doses of suxamethonium in four children with abnormal cholinesterase--a case report.
Four patients with genetic cholinesterase abnormalities were studied with electromyography after being given suxamethonium 0.1 mg/kg. An abnormal homozygous patient was paralysed for 17 minutes. The duration of response in heterozygous patients was 2-4 minutes, being shorter when cholinesterase activity levels were near normal.
Brown
T C
TC
Department of Anaesthesia, Royal Children's Hospital, Melbourne, Victoria, Australia.
Meretoja
O A
OA
Bell
B
B
Clare
D
D
D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D004576:Electromyography; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D002802:Cholinesterases; D013390:Succinylcholine