[Changes in systemic circulation and organ blood flow during induced total spinal block].
Total spinal block with lidocaine was performed in adult mongrel dogs, and circulatory changes or changes in organ blood flow were investigated. Dogs were divided into group A (5.1 mg.kg-1) and group B (10.0 mg.kg-1) according to the dose of lidocaine. During total spinal block, HR (79% and 78%), MAP (64% and 69%), LV dp/dt max (58% and 49%) and CI (67% and 67%) decreased significantly compared with the control values in groups A and B respectively. However, SVR was unchanged. The circulatory change occurred more rapidly in group B. Organ blood flow was measured in group A. Blood flow was measured in four areas during total spinal block. It was significantly decreased at liver and slightly decreased at cerebral cortex and medullary substance. However, renal cortex blood flow was not altered.
Kobori
M
M
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Negishi
H
H
Masuda
Y
Y
Hosoyamada
A
A
D000775:Anesthesia, Spinal; D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D004285:Dogs; D008012:Lidocaine; D012039:Regional Blood Flow / Q000502:physiology*
D008012:Lidocaine