[Establishment of standard strains of serotypes (groups) of Streptococcus pneumoniae in China].
Streptococcus pneumoniae is an important human pathogen which is responsible for life-threatening infections such as pneumonia, bacteremia and meningitis as well as for less severe but highly prevalent diseases such as otitis media and sinusitis. The number of serogroups (types) of Streptococcus pneumoniae found in the world is total 46 groups or 83 types according to typing system of Statens Serum Institute, Copenhagen, Denmark. The standard strains established in our lab of 42 groups or 67 types distributed in 17 different regions in China. The significance of this study is that two of the new serotypes (10C, 16A) are first reported in the literature in which the microbes were the agents causing pneumococcal infections. Our standard strains also include some serotypes on rare occasions such as 19C and 22A and 33C which have been found only in Asia. Our findings not only increase the total number of known types of pneumococci from 83 to 85, but also indicate that China has made progress in the field of pneumococcal research. It is the first time to report establishing a series of standard strains of pneumococci involving many serotypes (groups) in China. The work is necessary as a preliminary for pneumococcal disease prevention and treatment. The standard strains listed here with providing the resource of strain and scientific basis for developing vaccine and biological products.
Zhang
L
L
National Institute for the Control of Pharmaceutical and Biological Products, Beijing.
Yuan
Z
Z
Du
Z
Z
Xiao
Y
Y
Ding
S
S
D002681:China; D012015:Reference Standards; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*