[Effects of tiaprofenic acid on nasal mucociliary transport time].
Mucociliary activity is a fundamental aspect of the clearance function of the respiratory tract; mucociliary transport time being the easiest parameter to record in regard to the overall, more complex function of nasal clearance. A double blind, multicenter randomized study was carried out on 40 rhinopathy patients divided into two groups and treated with tiaprofenic acid 300 mg or a placebo twice a day for seven consecutive days. Before and after treatment the following were recorded: subjective and objective nasal MCT time, using an original composition of vegetable charcoal powder and saccharin powder at 3%; nasal obstruction. The authors conclude that the treatment of rhinitis with tiaprofenic acid improved not only the clinical symptomatology but also the mucociliary transport time and rhinomanometric examination.
Catalano
G B
GB
Clinica Otorinolaringoiatrica dell'Università di Catania.
Serra
A
A
Salami
A
A
Tinelli
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology* / Q000627:therapeutic use; D012220:Rhinitis / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid
Effetti dell'acido tiaprofenico sul tempo di transporto muco-ciliare nasale.