A clinical trial of Gingkco Biloba Extract in patients with intermittent claudication.
Thirty-seven patients with stage 2 peripheral vascular disease were randomised to receive a six month course of Gingkco Biloba Extract (Tanakan) or matching placebo. Assessment, by claudication distance, A/B ratio, Doppler ankle pressure response to exercise together with recovery time, and a 10 cm analogue scale (LAS) estimation of maximal pain severity, was performed before treatment, and at 6, 12 and 24 weeks. LAS scores were significantly improved after 24 weeks in patients receiving EgB, but not placebo. Claudication distance was significantly increased by Egb. Although claudication distance also increased in the placebo group, this was not significant. A/B ratio and Doppler ankle responses to exercise did not show any significant change in either group at any time interval, nor did the post exercise recovery time. Gingkco Biloba Extract is a safe and effective method of improving walking distance and reducing pain severity in patients with intermittent claudication, although Doppler studies have failed to suggest any gross improvement in the perfusion of the ischaemic leg.
Thomson
G J
GJ
Department of Vascular Surgery, Manchester Royal Infirmary, G.B.
Vohra
R K
RK
Carr
M H
MH
Walker
M G
MG
D004311:Double-Blind Method; D020441:Ginkgo biloba; D006801:Humans; D007383:Intermittent Claudication / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D013997:Time Factors; D014463:Ultrasonography; D000096983:Ginkgo Extract
D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract