Growth control in mammalian cells by cell-cell contacts.
Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.
Wieser
R J
RJ
Institute of Toxicology, Johannes Gutenberg University, Mainz, Federal Republic of Germany.
Renauer
D
D
Schäfer
A
A
Heck
R
R
Engel
R
R
Schütz
S
S
Oesch
F
F
D002448:Cell Adhesion / Q000502:physiology; D002449:Cell Aggregation / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D003260:Contact Inhibition / Q000502:physiology; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*
D010980:Platelet Membrane Glycoproteins