[Heat shock proteins and proliferative activity of cultured hepatocytes after hyperthermia].
Hepatocytes in cell culture have been studied for their sensitivity to mitogenic effect of the epidermal growth factor, epidermal growth factor and insulin, 10% of cattle blood serum after hyperthermia. It is established that heat shock (43 degrees C, 90 min) induces hypersensitivity of hepatocytes to the mentioned mitogens, its maximum being observed 20-24 h after hyperthermia and coinciding in time with the development of thermotolerance and intensification of protein biosynthesis after the heat shock 68, 70, 94 kD.
Osipova
L A
LA
Mukvich
A N
AN
Nemliĭ
N I
NI
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006979:Hyperthermia, Induced; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000166:cytology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D006360:Heat-Shock Proteins; D007328:Insulin; D008934:Mitogens; D004815:Epidermal Growth Factor
Belki teplovogo shoka i proliferativnaia aktivnost' gepatotsitov v kul'ture posle gipertermii.