Increased serum selenium levels in patients under corticosteroid treatment.
The normal serum and tissue levels of many micronutrients are remarkably affected by the therapeutical administration of several substances. In the present study, we have evaluated the modifications of serum selenium levels in different groups of patients under corticosteroid treatment. Such therapy was significantly associated with increased serum selenium levels, with a dose-dependent relationship in subjects treated with methylprednisolone. The reasons for this association are unknown. However, a reduced renal excretion of selenium, due to the mineralcorticoid activity of the corticosteroids, can be inferred.
Marano
G
G
Laboratory of Pharmacology, Institute of Health, Rome, Italy.
Fischioni
P
P
Graziano
C
C
Iannone
M
M
Morisi
G
G
D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy; D009422:Nervous System Diseases / Q000097:blood / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use*; D012643:Selenium / Q000097:blood*; D013224:Status Asthmaticus / Q000097:blood / Q000188:drug therapy
D003907:Dexamethasone; D012643:Selenium; D011241:Prednisone; D008775:Methylprednisolone