[Familial acute leukemia. Report of 7 cases in 3 families].
Seven members of 3 families developed acute leukemia (AL) between 1969 and 1988. The clinical presentation, course and response to treatment were no different to non-familial cases of AL. The morphology subtypes were identical in every family: myeloblastic in 3 and lymphoblastic in 4. Leukemogenic factors (radiation, drugs use or benzene exposure) were excluded in these patients. Genetical and environmental factors might have a role in the pathogenesis but no clear evidence has been established.
Sinco
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Departamento de Hematología, Hospital General de Zona, I.M.S.S., Pachuca, Hidalgo.
Avilés
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García
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D000328:Adult; D002648:Child; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*
Leucemia aguda familiar. Informe de siete casos en tres familias.