title: Lymphocytic infiltrates of the skin in association with cyclosporine therapy.
abstract: Three patients, one of whom has been previously reported, had erythematous papules and nodules of the face and upper part of the chest during cyclosporine therapy for inflammatory skin diseases. Histologic examination and DNA analysis (performed in two cases) revealed benign dermal lymphocytic infiltrates. In two cases proliferation of only T cells occurred. In the third case, both T and B cell populations were expanded and there was vacuolar degeneration of the basal layer of the epidermis and IgG, IgM, and C3 deposition along the dermoepidermal junction. These findings may be the result of cyclosporine-induced immune dysregulation. The lesions resolved in all patients after therapy was stopped.
authors: Department of Dermatology, Univ. of Michigan Medical Center, Ann Arbor 48109-0314.
authors: A K
authors: AK
authors: Gupta
authors: K D
authors: KD
authors: Cooper
authors: C N
authors: CN
authors: Ellis
authors: B J
authors: BJ
authors: Nickoloff
authors: C A
authors: CA
authors: Hanson
authors: M D
authors: MD
authors: Brown
authors: J J
authors: JJ
authors: Voorhees
mesh_terms: D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D003524:Cyclosporins