The osteoclast, which derives from a haemopoietic stem cell, is not depleted in aplastic anaemia.
The osteoclast derives from the haemopoietic stem cell but its relationship with the other progeny of the haemopoietic system is unknown. Osteoclast numbers were assessed in patients with aplastic anaemia and were found not to be depleted compared with a control population. This suggests that the osteoclast may develop along a separate lineage which is independent of the colony forming unit granulocyte, erythroid cell, monocyte, and megakaryocyte (CFU GEMM).
Flanagan
A M
AM
Department of Histopathology, St George's Hospital Medical School, London, U.K.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000473:pathology*; D001772:Blood Cell Count; D002452:Cell Count; D002454:Cell Differentiation; D002648:Child; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000473:pathology*