[Effect of daunomycin on epithelial cells of the crystalline lens. Experimental and clinical study].
Daunomycin action on human lens epithelial cells has been tested in vitro, with different exposure times. A clinical study on 30 eyes, operated on by the same surgeon, has been carried out according to the Cologne protocol. Cell cultures, with different techniques were grown. This demonstrates that Daunomycin can destroy the lens epithelial cells. We can not currently say what dosage and protocols are necessary to achieve a prevention of secondary cataract.
Sourdille
P
P
Clinique Sourdille, Nantes.
Ducournau
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000517:prevention & control; D002387:Cataract Extraction; D002478:Cells, Cultured; D003630:Daunorubicin / Q000494:pharmacology* / Q000627:therapeutic use; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000166:cytology / Q000187:drug effects*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control
D003630:Daunorubicin
Action de la daunomycine sur les cellules epithéliales du cristallin. Etude expérimentale et clinique.