Beta-2-microglobulin concentrations in pediatric human immunodeficiency virus infection.
Serum concentrations of beta-2-microglobulin (B2-M) were correlated with disease outcome in 40 children infected by the human immunodeficiency virus. Serum B2-M serum concentrations below 3.0 mg/100 ml or decreasing concentrations were indicative of a stable disease course but were also noted preterminally in lymphopenic children. Of 20 patients with B2-M concentrations above 3.0 mg/liter, 12 had a progressive disease course and 8 remained stable. In the latter 8 patients the B2-M values decreased with time. Elevated B2-M concentrations were also noted in infants younger than 1 year of age and denoted active human immunodeficiency virus infection. B2-M serum concentrations are a useful prognostic marker in human immunodeficiency virus-infected children.
Ellaurie
M
M
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Rubinstein
A
A
D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D011379:Prognosis; D011446:Prospective Studies; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin