title: Comparative study of secretion by vagotomized and isotransplanted stomachs in the rat.
abstract: An acute observation of gastric secretion by syngeneic stomach transplants in Lewis male rats was compared to the gastric secretory fate of normal, pylorus-ligated, vagotomized, and combined pylorus ligation and vagotomized Lewis rats. A 5 day observation was sufficient before sympathetic fibers and vagal channels could be regenerated. A total of 36 rats were divided into five groups of which group I (ten normals), group II (five vagotomized), group III (pylorus-ligated), group IV (six vagotomized and pylorus-ligated), and group V (five syngeneic stomach-transplanted, five animals served as donors), and those stomachs were intubated to collect gastric juice by housing animals in Bollman cages. Whereas group V animals secreted a mean 24 hr gastric juice volume of 12.5 +/- 6.4 ml with free acid secretion of 0.15 +/- 0.01 mEq/24 hr, animals in groups I, II, III, and IV secreted 24.4 +/- 2.9 ml, 23.3 +/- 1.1 ml, 25.5 +/- 3.4 ml, 22.4 +/- 0.5 ml, respectively, for 24 hr periods with free acid secretions of varying rates. From these observations, the transplanted stomach mean secretory rate averaged half that of the normal stomach.
authors: Third Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors: T
authors: T
authors: Ueda
authors: T
authors: T
authors: Kunitaka
authors: T
authors: T
authors: Tanaka
authors: T
authors: T
authors: Sakabe
mesh_terms: D000818:Animals; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007441:Intubation, Gastrointestinal; D008026:Ligation; D008297:Male; D011706:Pyloric Antrum / Q000601:surgery; D051381:Rats; D011917:Rats, Inbred Lew; D013270:Stomach / Q000294:innervation / Q000473:pathology / Q000637:transplantation*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology