Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?
The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.
Chopra
M
M
Dept. of Medicine, Clinical Pharmacology, Strathclyde University, Glasgow, Scotland.
McMurray
J
J
McLay
J
J
Bridges
A
A
Scott
N
N
Smith
W E
WE
Belch
J J
JJ
D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D016166:Free Radical Scavengers; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction
D016166:Free Radical Scavengers; D008315:Malondialdehyde; D002216:Captopril