[Effects of baicalin and liquid extract of licorice on sorbitol level in red blood cells of diabetic rats].
10 streptozotocin-induced diabetic rats were treated with baicalin 150 mg/kg.d and liquid extract of licorice (LEL) 7.5 ml/kg.d (5 by each medicine) for a week. The results indicated that orally baicalin and LEL could dramatically reduce the sorbitol levels in red blood cells (123.7 +/- 28.6 to 72.5 +/- 21.8 and 116.9 +/- 25.2 to 80.5 +/- 23.8 nmol/g.Hb, respectively) without affecting blood glucose levels significantly. It is suggested that both medicines act by inhibiting aldose reductase.
Zhou
Y
Y
Changhai Hospital, Second Military Medical University, Shanghai.
Zhang
J
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism; D005419:Flavonoids / Q000627:therapeutic use*; D006035:Glycyrrhiza; D010946:Plants, Medicinal; D013012:Sorbitol / Q000097:blood*
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C038044:baicalin; D013012:Sorbitol