Cytogenetic effect of the thiocarbamate herbicides butylate, molinate and vernolate in the mouse bone marrow micronucleus test.
Three thiocarbamate herbicides, butylate (S-ethyl-diisobutylthiocarbamate), vernolate (S-propyl dipropylthiocarbamate) and molinate (S-ethyl-N,N-hexamethylenethiocarbamate) were assayed for cytogenetic effect in the mouse bone marrow micronucleus test. Butylate was inactive in bone marrow, vernolate caused a marginal increase in the incidence of micronucleated polychromatic erythrocytes only at a high toxic dose level. Molinate, the N,N-hexamethylene derivative was, however, strongly active in the bone marrow, causing a high frequency of micronucleated erythrocytes, even at subtoxic concentrations.
Pintér
A
A
Department of Morphology, National Institute of Hygiene, Budapest, Hungary.
Csík
M
M
Török
G
G
Surján
A
A
Kelecsényi
Z
Z
Kocsis
Z
Z
D000818:Animals; D001381:Azepines / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D002875:Chromosomes / Q000187:drug effects*; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D015394:Molecular Structure; D009153:Mutagens; D013859:Thiocarbamates / Q000633:toxicity*
D001381:Azepines; D006540:Herbicides; D009153:Mutagens; D013859:Thiocarbamates; C039758:S,N,N'-tripropylthiocarbamate; C023898:butylate; C009821:molinate