[The importance of benziodarone in the treatment of gout and hyperuricemic syndrome].
The authors pay attention to benziodarone, a representative of the category of benzofurans. They test its effect on the uric acid serum level in normouraemic subjects as well as in hyperuricaemic syndrome and gouty arthritis. The hypouricaemic action of benziodarone (Amplivex-Labaz) is prompt. The maximum drop of uricaemia after Amplivex administration (2 tablets/day) occurs during the first three days. The uric acid level declines by as much as 80% of the baseline value. For long-term treatment 1 tablet per day is sufficient, in some instances even 1 tablet twice a week. The tolerance of the preparation is satisfactory. The authors deal also with the mechanism of action of benziodarone. Amplivex is not only a uricostatic but also a uricosuric agent.
Lindusková
M
M
Výzkumný ústav chorob revmatických, Praha.
Vykydal
M
M
D015210:Arthritis, Gouty / Q000097:blood / Q000188:drug therapy*; D001572:Benzofurans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000097:blood*; D014528:Uricosuric Agents / Q000627:therapeutic use*
D001572:Benzofurans; D014528:Uricosuric Agents; D014527:Uric Acid; C058702:benziodarone
Význam benziodaronu v lécbĕ dny a hyperurikemického syndromu.