Histiocytic cytophagic panniculitis.
A 33 year old man developed fever, malaise, jaundice, pancytopenia, coagulation abnormalities, hepatomegaly, pleural effusions and a subcutaneous lump. Biopsies revealed a lobular panniculitis with the presence of cytophagic histiocytes; erythrophagocytosis was also demonstrated in the liver and bone marrow. Despite the use of chemotherapy (CHOP) his clinical condition deteriorated and he died 5 months after presentation. This illness is consistent with the recently described syndrome of histiocytic cytophagic panniculitis.
Hilton
D A
DA
Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, UK.
O'Malley
B P
BP
Durrant
S T
ST
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D008297:Male; D015434:Panniculitis / Q000473:pathology*