[The role of serotonin and histamine in the neurohumoral mechanisms of postirradiation diarrhea in rats].
In experiments with rats exposed to 200 Gy radiation it was shown that the diarrhea effect of serotonin under the effect of radiation is implemented via D- and M-type receptors, and that of histamine via H1 and H2 receptors. Serotonin and histamine, that were released under the effect of radiation from endocrine and mast cells of the digestive tract, stimulated the propulsion activity of the intestine whereas histamine, in addition, inhibited the absorption process. It is suggested that serotonin and histamine antagonists should be used as means of preventing of radiation-induced diarrhea.
Legeza
V I
VI
Shagoian
M G
MG
Markovskaia
I V
IV
Vasil'eva
T P
TP
Pozharisskaia
T D
TD
Alekseeva
I I
II
Lokteva
O I
OI
D000818:Animals; D002588:Cesium Radioisotopes; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D005720:Gamma Rays; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000627:therapeutic use; D008297:Male; D011833:Radiation Injuries, Experimental / Q000150:complications*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000627:therapeutic use
D002588:Cesium Radioisotopes; D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine
O roli serotonina i gistamina v neĭrogumoral'nykh mekhanizmakh postluchevoĭ diarei u krys.