title: A hydrogel pericardial patch.
abstract: Patients undergoing repeat cardiac operations are higher operative risks than those undergoing an initial cardiac procedure because adhesion formation can occur if the native pericardium is not closed. A unique composite patch that may be used to augment the pericardial tissue when primary closure is not possible has been developed. The patch is made of a hydrogel, poly (2-hydroxyethyl methacrylate), reinforced with an ethylene tetrafluoroethylene (ETFE) mesh. The mesh provides the needed mechanical properties, whereas the patch's surface properties are comparable to the hydrogel. Two types of patches were fabricated: one with the mesh weave at a perpendicular orientation and one at 45 degrees to the principle loading direction. The patches were mechanically tested and compared with canine pericardium. Ultimate tensile strength of the patches is not significantly different from canine pericardium (p less than 0.05), are the patch suture strength is nearly twice that of canine pericardium. The perpendicular patch is stiffer than canine pericardium, whereas the 45 degree patch is not (p less than 0.05). The 45 degree patch shows considerable promise as a pericardial substitute because it closely matches the properties native canine pericardium.
authors: Department of Chemical, Bio, and Materials Engineering, Arizona State University, Tempe 85287-6006.
authors: M A
authors: MA
authors: Allder
authors: E J
authors: EJ
authors: Guilbeau
authors: T A
authors: TA
authors: Brandon
authors: A S
authors: AS
authors: Walker
authors: J B
authors: JB
authors: Koeneman
authors: R L
authors: RL
authors: Fisk
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D004285:Dogs; D006801:Humans; D008689:Methacrylates; D010496:Pericardium / Q000601:surgery*; D011102:Polyhydroxyethyl Methacrylate; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; C059480:poly(hydroxyethyl methacrylate-methacrylic acid)hydrogel