[Uptake and K+-evoked release of 3H-norepinephrine in the mesodiencephalic synaptosomes of albino rats during aging. Role of N-acetyl-L-aspartic acid].
The uptake and K(+)-evoked (40 mM) release of 3H-norepinephrine (3H-NE) in mesodiencephalic synaptosomes of adult and senescent rats and the effect of N-acetylaspartic acid (NAA) on these processes have been studied. It has been shown that the uptake of 3H-NE by old rats is reduced considerably. The K(+)-evoked release of 3H-NE from rats synaptosomes is significantly decreased in aged rats. In the presence of 10(-4)-3.10(-3) M NAA the uptake of 3H-NE by adult and senescent rats synaptosomes remains unchanged. In these concentrations NAA inhibits the K(+)-evoked release of 3H-NE from synaptosomes of adult rats, but it exerts no effect on this process in senescent rats.
Armenian
A R
AR
Institute of Biochemistry, Academy of Sciences of the Armenian SSR, Yerevan.
Arakelian
L N
LN
Aprikian
G V
GV
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000502:physiology; D004027:Diencephalon / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D001224:Aspartic Acid; C000179:N-acetylaspartate; D011188:Potassium; D009638:Norepinephrine
Zakhvat i K+-vyzvannoe vysvobozhdenie 3H-noradrenalina v mezodiéntsefal'nykh sinaptosomakh belykh krys pri starenii. Rol' N-atsetil-L-asparaginovoĭ kisloty.