Cadherin-mediated cell-cell adhesion and neurogenesis.
Cadherins constitute a molecular family which confers adhesive specificities on cells. Their expression is spatio-temporally regulated in embryos and the multiple types of cadherins are expressed in the nervous system. The inhibition of cadherin action with antibodies resulted in the perturbation of the histogenesis of neural tissues. The sites for determining the binding specificities of cadherins reside in their amino terminal 113 amino acid region. Possible roles of cadherins associated with these properties in neurogenesis are discussed.
Takeichi
M
M
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
Inuzuka
H
H
Shimamura
K
K
Matsunaga
M
M
Nose
A
A
D000818:Animals; D001666:Binding Sites, Antibody; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002448:Cell Adhesion; D009417:Nerve Tissue / Q000196:embryology* / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D009474:Neurons / Q000502:physiology*
D015820:Cadherins