N-acetylcysteine in the treatment of human arsenic poisoning.
A 32-year-old man was brought to the emergency department 5 1/2 hours after ingesting a potentially lethal dose (900 mg) of sodium arsenate ant poison in a suicide attempt. The patient deteriorated progressively for 27 hours. After intramuscular dimercaprol and supportive measures failed to improve his condition, he was given N-acetylcysteine intravenously. The patient showed remarkable clinical improvement during the following 24 hours and was discharged from the hospital several days later.
Martin
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DS
Department of Family Medicine, East Carolina University, School of Medicine, Greenville, NC.
Willis
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SE
Cline
D M
DM
D000111:Acetylcysteine / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D001149:Arsenates / Q000037:antagonists & inhibitors / Q000506:poisoning*; D003422:Critical Care; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013406:Suicide, Attempted; D013997:Time Factors
D000931:Antidotes; D001149:Arsenates; C009277:sodium arsenate; D000111:Acetylcysteine