[Morphological observation of destruction and phagocytosis of the target organs by human lung adenocarcinoma cell line in organ culture].
In a co-culture system of human lung adenocarcinoma cells (LTEP-a2) with tissue fragments of human heart and liver, it was found that the target organs were destroyed with cancer cells invading. The destruction shown as cell swelling, atrophy, fatty degeneration and disappearance of the cardiac muscle streak, myocomma and local cell membrane, always occurred at sites immediately in contact with the invading cancer cells. However, cell changes could develop not in direct contact with tumor cells. The farther invasion by the tumor cells, the more serious destruction was seen. It was also observed that the tumor cytoplasmic processes could surround debris derived from the target tissue and the debris could be found inside cancer cells. The rapidly invading cells contained more phagosomes than the slowly invading ones.
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Haerbin Medical College.
D000230:Adenocarcinoma / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D009361:Neoplasm Invasiveness; D009924:Organ Culture Techniques; D010587:Phagocytosis; D010588:Phagosomes; D014407:Tumor Cells, Cultured