[The effect of adenosine on the distribution of glucocorticoid receptor complexes in rat thymocytes].
In presence of adenosine (10(-7)-10(-6) M) content of nuclear 3H-hydrocortisone-receptor complexes was increased in rat thymus lymphocytes, while amount of these complexes was decreased in cytosol of these cells. DEAE-cellulose chromatography of the 3H-hydrocortisone-receptor complexes demonstrated that adenosine 1.10(-6) M altered the ratio between active and non-active forms of the hormone-receptor complex. Adenosine appears to regulate transformation and translocation of the glucocorticoid-receptor complexes into the cell-target nuclei cAMP-dependent apparatus.
Dukhanin
A S
AS
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D006854:Hydrocortisone / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D000241:Adenosine; D006854:Hydrocortisone
Vliianie adenozina na raspredelenie gliukokortikoidretseptornykh kompleksov v timotsitakh krys.