In vitro replication of Bovid herpesvirus-1 in macrophages derived from peripheral blood leucocytes of calves.
Macrophages derived from peripheral blood leucocytes of calves from 1 to 100 days of age supported the replication of Bovid herpesvirus-1 (BHV-1) without apparent cytopathic effects. The replication of the virus was abortive, replication being restricted to limited numbers of passages. The abilities of macrophages to support replication of BHV-1 were similar for calves from 1 day to 100 days of age (P greater than 0.05). The replication of BHV-1 in macrophages did not significantly affect the capacity of macrophages to phagocytose and kill Staphylococcus aureus (P greater than 0.05).
Woldehiwet
Z
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Department of Veterinary Pathology, University of Liverpool, Leahurst, Neston, Wirral, U.K.
Rowan
T G
TG
D000818:Animals; D000831:Animals, Newborn / Q000097:blood* / Q000254:growth & development; D001770:Blood Bactericidal Activity; D002417:Cattle / Q000097:blood*; D002460:Cell Line; D006564:Herpesviridae / Q000502:physiology*; D007962:Leukocytes / Q000166:cytology*; D008264:Macrophages / Q000382:microbiology*; D014779:Virus Replication