[Effects of the decrease of hydrodynamic resistance of a solution on response of cerebral arteries in perfusion].
Acute experiments on isolated segments of carotid arteries of cats and on human middle cerebral arteries have demonstrated the narrowing effect (15-18%) during the perfusion with solution of polymer with extraordinary lengthy (WSR-301, USA) in concentration of 2.10(-6) g/ml. Effects were doze- and endothelial dependent. It has been established that arteries responded to minor changes in experiments with the increase of the fluid flow (from 15 to 40 ml/min). It may be concluded that the diminishing of arteries reaction in the presence of polymer solution depended on the drug reduction polymer influence on shear stress, and changing of angio-hemo relationships.
Gannushkina
I V
IV
Gabrielian
E S
ES
Akopov
S E
SE
D000818:Animals; D002339:Carotid Arteries / Q000502:physiology*; D002415:Cats; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D011092:Polyethylene Glycols; D012996:Solutions
D012996:Solutions; D011092:Polyethylene Glycols
Vliianie snizheniia gidrodinamicheskogo soprotivleniia zhidkosti na reaktsii mozogovykh arteriĭ pri perfuzii.