title: [Elimination of viscoelastic substances from the vitreous cavity. Comparative study of sodium hyaluronate and hydroxypropylmethylcellulose].
abstract: We study the elimination of two viscoelastic substances from the vitreous cavity: the Hydroxypropyl Methylcellulose and the Sodium Hyaluronate that are potentially vitreous substitutes. We performed gas-vitrectomy in 116 eyes of 58 rabbits. Three days after surgery we performed gas-viscoelastic substance exchange. We analyzed the concentration of Hydroxypropyl Methylcellulose and Sodium Hyaluronate with diphenylamine reaction at different periods: zero, 1 week, 2 weeks, 1 month till 6 months. In both cases the elimination is fast so that 1 week after the intravitreal injection remains only 60.1% of the Hydroxypropyl Methylcellulose and 100% of Sodium Hyaluronate, and two weeks after 38.5% of Hydroxypropyl Methylcellulose and 62.5% of Sodium Hyaluronate. We conclude that both substances have a short half life-time specially in the case of the Hydroxypropyl Methylcellulose.
authors: Departamento de Oftalmologia, Universidad de Santiago de Compostela, España.
authors: J
authors: J
authors: Fernandez-Vigo
authors: J F
authors: JF
authors: Sabugal
authors: J A
authors: JA
authors: Diaz
authors: A
authors: A
authors: Concheiro
authors: R
authors: R
authors: Martinez
mesh_terms: D000818:Animals; D006820:Hyaluronic Acid / Q000493:pharmacokinetics*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011817:Rabbits; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid; D008747:Methylcellulose
vernacular_title: Elimination de substances visco-élastiques hors de la cavité vitréenne. Etude comparative entre l'hyaluronate sodique et l'hydroxy-propyl-méthyl-cellulose.