[A microangiographic study of the damaged liver in acute radiation sickness].
Microangiographic investigation with intravital filling up of the vessels was used to study a course and regeneration of a liver lesion in rats irradiated at a dose of 6 Gy. A traumatic liver lesion is characterized by severe local disorders of blood circulation, sharp vasoconstriction and depletion of the entire liver microcirculatory network. Combined radiation injuries result in phase changes: parenchymal edema, liver microcirculatory depletion in the early posttraumatic period change into relative normalization of the blood circulation of uninjured liver tissue in the latent period. Parenchymal edema, vasodilation and hypostasis reappear at the height of a lesion, followed by rarefaction of the network and vasoconstriction of the microcirculatory bed. Necrotic mass resorption in the period of combined radiation injury is as active as that in unirradiated animals. However at the height of a radiation injury capillary regeneration and necrotic mass resorption cease resulting in retarded regeneration of injured tissues.
Mamadzhanov
T M
TM
D000208:Acute Disease; D000818:Animals; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000293:injuries / Q000473:pathology / Q000528:radiation effects*; D008852:Microradiography / Q000379:methods; D009104:Multiple Trauma / Q000000981:diagnostic imaging / Q000473:pathology; D009336:Necrosis / Q000000981:diagnostic imaging / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014916:Whole-Body Irradiation
Mikroangiograficheskoe issledovanie povrezhdennoĭ pecheni pri ostroĭ luchevoĭ bolezni.