[The persistence of the causative agent of amyotrophic leukospongiosis and the astrocyte reaction in monolayer cultures of brain cells].
The amyotrophic leukospongiosis (AL) agent which is considered to be an unconventional virus was shown to replicate and amplify in non-neuronal monolayer brain cell cultures. The AL agent persistence was accompanied by complicated morphofunctional changes in astrocytes, some of them developing a specific cytodystrophic process. Phagocytosis in the infected astrocytes came to its end. The dose-dependent effect and selective sensitivity of these cells to the cytodestructive activity of AL was demonstrated. Astrocytes are regarded to be target cells serving as a reservoir for agent amplification.
Poleshchuk
N N
NN
Kvacheva
Z B
ZB
Il'kevich
Iu G
IuG
Kolomiets
N D
ND
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000382:microbiology* / Q000648:ultrastructure; D001927:Brain Diseases / Q000382:microbiology* / Q000473:pathology; D002472:Cell Transformation, Viral; D002478:Cells, Cultured / Q000382:microbiology; D006168:Guinea Pigs; D006801:Humans; D008854:Microscopy, Electron; D009046:Motor Neurons; D009468:Neuromuscular Diseases / Q000382:microbiology* / Q000473:pathology; D010587:Phagocytosis; D012897:Slow Virus Diseases / Q000382:microbiology* / Q000473:pathology
Persistentsiia vozbuditelia amiotroficheskogo leĭkospongioza i reaktsiia astrotsitov v monosloĭnykh kul'turakh kletok mozga.