Allele losses on chromosome 17 in human epithelial ovarian carcinoma.
16 epithelial ovarian carcinomas (12 serous, 2 mucinous and 2 endometrioid) and 2 benign ovarian adenomas were studied using recombinant DNA technology to compare loci on chromosome 17 in germ-line and tumour DNA. Four polymorphic probes mapping to 17p and one mapping to 17q were used. There was a high frequency of allele loss on 17q/(77%) and a slightly lower frequency on 17p (69%). These findings probably indicate loss of tumour suppressor genes which are of fundamental importance in the genesis or progression of epithelial ovarian carcinomas.
Eccles
D M
DM
ICRF, Edinburgh Medical Oncology Unit, Western General Hospital, UK.
Cranston
G
G
Steel
C M
CM
Nakamura
Y
Y
Leonard
R C
RC
D000236:Adenoma / Q000235:genetics*; D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D002460:Cell Line; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D015183:Restriction Mapping
D004273:DNA, Neoplasm