[The relationship between antipyrine kinetics and the change in the seromucoid content of rat plasma under the influence of the immunomodulator levamisole].
The relationship between levamisole-induced changes in seromucoid levels and drug metabolism was studied. In the single dose study rats received levamisole hydrochloride (25 mg/kg by gastric intubation 24 hours before antipyrine administration in a dose of 10 mg/rat intravenously). This resulted in a decrease of antipyrine clearance and an increase of half-life. In contrast, the multiple administrations (5 mg/kg for 2 days in a week for 3 weeks) had no significant effect on the pharmacokinetics of antipyrine. However, in both cases seromucoid levels were elevated. It is concluded that the research on the effect of levamisole on drug metabolism and drug binding to plasma proteins in man is needed.
Kupchikov
V V
VV
Bender
K I
KI
Lutsevich
A N
AN
Gangnus
V S
VS
D000276:Adjuvants, Immunologic; D000818:Animals; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics*; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D009961:Orosomucoid / Q000032:analysis*; D051381:Rats; D013997:Time Factors
D000276:Adjuvants, Immunologic; D001798:Blood Proteins; D009961:Orosomucoid; D007978:Levamisole; D002784:Cholesterol; D000983:Antipyrine
Sviaz' mezhdu kinetikoĭ antipirina i izmeneniia soderzhaniia seromukoida v plazme krys pod vliianiem immunomoduliatora levamizola.