Teratological assessment of the antiprotozoal, diminazene diaceturate, in rats.
Diminazene diaceturate was dissolved in deionized water and administered to pregnant rats by oral gavage once daily on days 8-15 of pregnancy at dose levels of 0, 100, 250, 500 and 1000 mg/kg. On day 21 of pregnancy, the dams were killed and the number of implants, resorptions and live fetuses counted. All fetuses were examined by routine teratological method. A significant increase in fetal resorptions and decrease in fetal body weights were found at the 1000 mg/kg dose. No significant increase in the incidence of anomalous fetuses was observed in external, skeletal and internal examinations even at the maternally toxic dose of 1000 mg/kg. Thus, these data indicate that diminazene diaceturate is not teratogenic in rats.
Yoshimura
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National Veterinary Assay Laboratory, Tokyo, Japan.
D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004133:Diminazene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens
D000981:Antiprotozoal Agents; D013723:Teratogens; C003915:diminazene aceturate; D004133:Diminazene