title: Fatty acid binding protein in flight muscle of the locust, Schistocerca gregaria.
abstract: The cytosol of flight muscle from the adult desert locust, Schistocerca gregaria, contains a fatty acid binding protein (FABP). Locust FABP has a molecular weight of 15,000 and an isoelectric point of 5.2. It binds fatty acids stoichiometrically in a 1:1 ratio. Its molecular characteristics, tissue specificity and electrophoretic behavior are reminiscent of mammalian M-FABP. Compared to its mammalian counterpart, the cytosolic concentration is much higher, reflecting the high rate of fatty acid oxidation observed during locust flight. Our discovery, showing for the first time an FABP in an invertebrate species, supports the proposed function of muscle FABP as intracellular fatty acid receptor or transport protein.
authors: Department of Biological Sciences, Simon Fraser University, Burnaby, Canada.
authors: N H
authors: NH
authors: Haunerland
authors: J M
authors: JM
authors: Chisholm
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005426:Flight, Animal; D006110:Grasshoppers / Q000378:metabolism*; D007525:Isoelectric Focusing; D008970:Molecular Weight; D009132:Muscles / Q000378:metabolism*; D009363:Neoplasm Proteins
chemical_list: D000596:Amino Acids; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins