Indomethacin attenuation of celiac blood flow hyperemia following glutathione depletion.
The effect of glutathione (GSH) depletion on mean celiac blood flow (MCBF) was determined in domestic fowl. Diethyl maleate (DEM, 1 mL/kg body wt) decreased hepatic and duodenal GSH to approximately 15% of control. This GSH depletion was associated with an increase in MCBF and decreases in mean arterial blood pressure (MABP) and celiac vascular resistance (CVR). While indomethacin attenuated the rise in MCBF, this cyclooxygenase inhibitor had no effect on the decrease of MABP or CVR which occurred following DEM treatment. The results indicate that GSH depletion may increase vasodilatory prostaglandin synthesis since elevations in MCBF were attenuated by cyclooxygenase inhibition.
Beers
K
K
Department of Animal and Poultry Sciences, University of Arkansas, Fayettesville 72701.
Nejad
H
H
Bottje
W
W
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002445:Celiac Artery / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects
D005978:Glutathione; D007213:Indomethacin