title: [The role of cholesterol and phosphatidylcholine on very low density lipoprotein secretion from rat hepatocytes].
abstract: The role of cholesterol and phosphatidylcholine on hepatic very low density lipoprotein secretion was investigated with rat hepatocytes. Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidylcholine content. However, cholesterol loading into hepatocytes did not affect hepatic very low density lipoprotein secretion. Hepatic apolipoprotein contents were constant and were not influenced by a change of hepatic cholesterol and phosphatidylcholine contents. These results suggest that lipids, which are constituents of lipoproteins, play different roles on hepatic very low density lipoprotein secretion.
authors: First Department of Internal Medicine, Hiroshima University School of Medicine.
authors: K
authors: K
authors: Hayashi
authors: K
authors: K
authors: Nakashima
authors: S
authors: S
authors: Dojo
authors: Y
authors: Y
authors: Hirata
authors: H
authors: H
authors: Ohtani
authors: M
authors: M
authors: Saeki
authors: H
authors: H
authors: Kurushima
authors: E
authors: E
authors: Nishio
authors: M
authors: M
authors: Hiraoka
authors: M
authors: M
authors: Ito
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000502:physiology*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D010713:Phosphatidylcholines / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008079:Lipoproteins, VLDL; D010713:Phosphatidylcholines; D002784:Cholesterol