Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.
NF-kappa B and H2TF1 are transcription factors that bind to related DNA sequence motifs. NF-kappa B is a constitutive factor in mature B lymphocytes and is inducible in immature B cells and nonlymphoid cells. H2TF1 is a constitutive ubiquitous transcription factor that activates expression of major histocompatibility complex class I genes. We report here the isolation of two zinc finger genes. One, named MBP-2 (major histocompatibility complex-binding protein 2), encodes a factor that has DNA-binding properties similar, if not identical, to the H2TF1 transcription factor. The second, named KBP-1 (kappa-enhancer binding protein 1), encodes a factor that is similar to, but distinct from, NF-kappa B in its DNA-binding properties and methylation interference pattern, suggesting that at least two proteins can bind to the immunoglobulin kappa gene enhancer.
Rustgi
A K
AK
Laboratory of Molecular Genetics, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129.
Van 't Veer
L J
LJ
Bernards
R
R
D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D004742:Enhancer Elements, Genetic; D005796:Genes; D008285:Major Histocompatibility Complex; D008745:Methylation; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000235:genetics*; D052002:NF-kappa B p50 Subunit; D009841:Oligonucleotides; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D009841:Oligonucleotides; D014157:Transcription Factors