HLA-associated susceptibility to acquired immune deficiency syndrome in HIV-1-seropositive subjects.
No difference in HLA-A, B or DR gene frequencies could be observed between 172 control subjects and 180 HIV-1-seropositive subjects of European ancestry diagnosed through the systematic screening of blood donations. In contrast, progression to acquired immune deficiency syndrome (AIDS; 21 patients) or CD4 lymphocyte loss equal or more than 20% over a 6-month period (37 subjects) was found to be associated with the B8DR3 haplotype (relative risk = 10.64, p less than 0.003, and 2.23, p less than 0.092, respectively). Other independently significant associations assessed through the multivariate Cox proportional-hazards model were B16, BW21 and B35 alleles as factors of bad prognosis. Conversely, A11 and DR4 alleles were factors favouring longer survival.
Kaplan
C
C
Institut National de Transfusion Sanguine, Paris, France.
Muller
J Y
JY
Doinel
C
C
Lefrère
J J
JJ
Paquez
F
F
Rouger
P
P
Salmon
D
D
Salmon
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D015704:CD4 Antigens / Q000235:genetics; D015331:Cohort Studies; D004198:Disease Susceptibility; D005260:Female; D006679:HIV Seropositivity / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D016019:Survival Analysis
D015704:CD4 Antigens; D006680:HLA Antigens