title: Meibomian therapy in problematic contact lens wear.
abstract: Utilizing the principal diagnostic criterion of an absent or cloudy Meibomian gland secretion upon repeated expression, patients with Meibomian gland dysfunction (MGD) were selected to participate in a study of the efficacy of lid scrubs and massage in the treatment of MGD. Twenty-one patients with contact lens intolerance unrelated to lens, care system, or health factors were randomly assigned to treatment of one eye with common clinical therapy for MGD. After 2 weeks of treatment, gland expression, biomicroscopy, staining, comfort, and fluorescein breakup time were assessed in a masked manner. Analyzed using a paired-data t-test, the results indicated a significant increase in mean tear film breakup time (BUT) in the treated eye at follow-up compared to baseline (mean increase = 4.0 s, p = 0.0001). The control eye demonstrated no significant change (mean increase = 0.2 s, p = 0.5955). These objective results were corroborated by reports of improved subjective comfort with contact lens wear after therapy.
authors: Allergan Optical, Irvine, California.
authors: J R
authors: JR
authors: Paugh
authors: L L
authors: LL
authors: Knapp
authors: J R
authors: JR
authors: Martinson
authors: M M
authors: MM
authors: Hom
mesh_terms: D000328:Adult; D003261:Contact Lenses; D015352:Dry Eye Syndromes / Q000209:etiology; D005141:Eyelid Diseases / Q000150:complications / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D008405:Massage; D008537:Meibomian Glands / Q000378:metabolism; D013666:Tears / Q000378:metabolism