title: Revision of the amino acid sequence of human heart fatty acid-binding protein.
abstract: Cardiac-type fatty acid-binding protein (cFABP) from human heart muscle of three individuals was isolated and characterized as pI 5.3-cFABP. The proteins were structurally analyzed by tryptic peptide mapping, application of plasma desorption time-of-flight mass spectrometry and amino acid sequencing. All three preparations of human heart FABP, having 132 amino acids, differed from the published sequence [Offner et al. Biochem J 251: 191-198, 1988] in position 104, where Leu is found instead of Lys, and in position 124, where Cys is found instead of Ser.
authors: Department of Biochemistry, University of Münster, FRG.
authors: T
authors: T
authors: Börchers
authors: P
authors: P
authors: Højrup
authors: S U
authors: SU
authors: Nielsen
authors: P
authors: P
authors: Roepstorff
authors: F
authors: F
authors: Spener
authors: J
authors: J
authors: Knudsen
mesh_terms: D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000737:chemistry*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D007526:Isoelectric Point; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009206:Myocardium / Q000737:chemistry*; D009363:Neoplasm Proteins; D010449:Peptide Mapping; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins