[Analysis of the indicators of central and peripheral hemodynamics in families with arterial hypertension].
Arterial pressure was studied by ++tacho-oscillography, and the central and peripheral hemodynamics were examined by tetrapolar rheography in members of 62 families with essential arterial hypertension. A geneticodispersion analysis was made of phenotypic dispersion of the parameters under study. The genetic determinant with an X-chromosome effect was established for minimal and lateral systolic pressure; that with a maternal effect for mean pressure. A high degree of the inheritance of the varieties of the central hemodynamics was discovered. Analysis of the peripheral hemodynamics points to an important role played by venoconstriction in the establishment of arterial hypertension. A high level of genetic determination with an X-chromosome effect was found for the readings of the leg rheogram (beta, alpha + alpha, alpha + beta/RR), responsible for the blood content and venous outflow. The data obtained provide evidence in favour of the prospective + search for genetic markers among the parameters of arterial pressure, the central and peripheral hemodynamics.
Beliaeva
L M
LM
Rostovtsev
V N
VN
Novik
I I
II
D000293:Adolescent; D000328:Adult; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply*; D008297:Male; D010641:Phenotype; D014960:X Chromosome
Analiz pokazateleĭ tsentral'noĭ i perifericheskoĭ gemodinamiki v sem'iakh s arterial'noĭ gipertenzieĭ.