[Iatrogenic fluorosis. 2 cases].
Two new cases of osteofluorosis are presented. They are attested by the existence of a bone X-ray densification, by histological lesions of hyperosteoidosis and a large increase in the fluorine content. One is a 61 year-old man who consumed 2.5 l a day of Vichy St-Yorre (a mineral water containing 8 mg of fluorine ions per litre) during 11 years; the other, an 86 year-old man who during 20 years took 500 mg of niflumic acid a day, a non-steroidal anti-inflammatory drug containing 3 fluorine atoms per molecule (i.e., 50 mg fluorine per 250 mg gellule). Both these hypertensive patients had severe renal insufficiency. These two observations serve as a reminder of the indispensable precautions to be observed when prescribing fluorine salts in the treatment of post-menopausal osteoporosis: at least the plasma creatinine level should be available in order to calculate the endogenous creatinine clearance and any possible supplementary intake of fluorine salts should be checked.
Welsch
M
M
Centre Régional de Pharmacovigilance Alsace et Service d'Hypertension et Maladies vasculaires, Hôpital Civil, Strasbourg.
Bloch
J G
JG
Stephan
D
D
Bloch
R
R
Imbs
J L
JL
D000368:Aged; D000369:Aged, 80 and over; D001847:Bone Diseases / Q000139:chemically induced*; D005461:Fluorine / Q000506:poisoning*; D006801:Humans; D007049:Iatrogenic Disease; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008900:Mineral Waters / Q000009:adverse effects; D009544:Niflumic Acid / Q000009:adverse effects; D012307:Risk Factors
D008900:Mineral Waters; D005461:Fluorine; D009544:Niflumic Acid
Fluorose iatrogène. Deux observations.