[Autoantibodies against histones and actin determined by western blotting in patients with rheumatic diseases].
Using the Western blot method, the authors analyzed 85 sera obtained from patients with rheumatic diseases, focused on the presence of antihistones and antiactin autoantibodies. The authors detected a 32% incidence of the two investigated autoantibody specificities. In a group of 42 patients with systemic lupus erythematosus in 22 sera (52%) positive antihistone antibodies were present, whereby autoantibodies anti-H1 and anti-H2B were most frequent. In 15 sera in this group of patients (36%) antiactin autoantibodies were present.
Raska
I
I
Ustav experimentální medicíny, CSAV, Praha.
Petrasovicová
V
V
Jarník
M
M
Cebecauer
L
L
Lukacovicová
L
L
Lejnar
J
J
Viklický
V
V
Mácha
J
J
Jíra
M
M
Trnavský
K
K
D000199:Actins / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D006657:Histones / Q000276:immunology*; D006801:Humans; D012216:Rheumatic Diseases / Q000276:immunology*
D000199:Actins; D001323:Autoantibodies; D006657:Histones
Autoprotilátky proti histonům a aktinu u nemocných s revmatickými onemocnĕními urcené metodou western blotu.