[Hetero-oligoproteins containing pancreatic ribonuclease--enzyme conjugates of prolonged action].
Conjugates containing blood serum albumin and pancreatic ribonuclease, produced by means of polycondensation reaction, exhibited higher half-life in rabbit circulation as compared with non-modified enzyme. Presence of the protein-carrier contributed to elevation of the ribonuclease therapeutic efficiency and enabled to decrease the quantity of injections.
Goriacheva
L K
LK
Medvedev
M L
ML
Samsonov
G V
GV
Ponomareva
R B
RB
D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006207:Half-Life; D011817:Rabbits; D012259:Ribonuclease, Pancreatic / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D012709:Serum Albumin / Q000138:chemical synthesis / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012709:Serum Albumin; D012259:Ribonuclease, Pancreatic
Geterooligoproteiny, vkliuchaiushchie pankreaticheskuiu ribonukleazu,--fermentnye kon''iugaty prolongirovannogo deĭstviia.