[Eosinophil colony stimulating activity induced by administration of interleukin-2 into the pleural cavity of patients with malignant pleurisy].
Systemic administration of interleukin-2 (IL-2) in patients with malignant diseases induces peripheral eosinophilia. In the present study, to clarify the mechanisms of eosinophilia induced by IL-2, we examined the changes in the number of eosinophils and in eosinophil colony stimulating activity (Eo-CSA) in the pleural fluid of six patients with malignant pleurisy caused by lung cancer or malignant mesothelioma, during and after intrapleural administration of IL-2. Results showed that intrapleural administration of IL-2 induced marked eosinophilia in the pleural fluid and mild eosinophilia in the peripheral blood, and that during IL-2 administration, marked Eo-CSA appeared in the pleural fluid before increase in the number of eosinophils. The Eo-CSA seemed to be a polypeptide or protein because it was trypsin-sensitive and had a molecular weight of 40-60 kDa.
Nakamura
Y
Y
Third Department of Internal Medicine, Tokushima University, School of Medicine, Japan.
Ozaki
T
T
Kamei
T
T
Kawaji
K
K
Fujisawa
K
K
Nii
A
A
Yanagawa
H
H
Nishioka
Y
Y
Shimizu
E
E
Sone
S
S
D000368:Aged; D003115:Colony-Stimulating Factors / Q000032:analysis*; D004802:Eosinophilia; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D016066:Pleural Effusion, Malignant / Q000276:immunology / Q000628:therapy*
D003115:Colony-Stimulating Factors; D007376:Interleukin-2