Pharmacokinetic comparison of two carbamazepine slow-release formulations.
In a single-blind pharmacokinetic study patients being treated with conventional carbamazepine (CBZ) in a t.i.d. regimen were randomly allocated to identical doses of two CBZ slow-release formulations (Trimonil Retard and Tegretol Retard) administered once daily. Statistical analysis involved the following parameters: AUC, Cmin, Cmax and Fluctuation Index (FI). With regard to Cmin and FI statistically significant differences in favour of Tegretol Retard were observed.
Jensen
P K
PK
University Clinic of Neurology, Hvidovre Hospital, Denmark.
Møller
A
A
Gram
L
L
Jensen
N O
NO
Dam
M
M
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D016037:Single-Blind Method
D003692:Delayed-Action Preparations; D002220:Carbamazepine