title: Bacterial vaginosis and the effect of intermittent prophylactic treatment with an acid lactate gel.
abstract: Intermittent treatment with an acid lactate gel (Lactal, ACO, Sweden) reduced symptoms of bacterial vaginosis (BV) and promoted the reestablishment of the normal vaginal flora of lactobacilli. Forty-two women seriously affected by recurrent BV were initially given acid gel (lactate gel, pH 3.8, 5 ml) to be inserted into the vagina daily for 7 consecutive days. Thereafter they entered into a double blind clinical trial and were treated prophylactically 3 days monthly for 6 months with either lactate gel or a placebo gel. Women treated with the lactate gel were clinically improved, i.e. no signs of BV in 88% compared to 10% in the placebo group (p less than 0.001). The vaginal lactobacilli flora was reestablished in 83% of the lactate group and in 16% of the placebo group. Local intermittent application of lactate gel was found to be free of side effects and is a preferable alternative to repeated treatments with antibiotics in patients with recurrent BV.
authors: Department of Obstetrics and Gynecology, Ostra Sjukhuset, Göteborg, Sweden.
authors: B
authors: B
authors: Andersch
authors: D
authors: D
authors: Lindell
authors: I
authors: I
authors: Dahlén
authors: A
authors: A
authors: Brandberg
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000008:administration & dosage / Q000627:therapeutic use*; D019344:Lactic Acid; D014621:Vagina / Q000382:microbiology / Q000503:physiopathology; D014627:Vaginitis / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D005782:Gels; D007773:Lactates; D019344:Lactic Acid