[Role of cathepsin D in the appearance of micronuclei in lung cells of mice immunized with influenza vaccine].
The positive correlation of micronuclei quantity appearance and catepsin D activation in mice cells after immunization by alive influenza vaccine was demonstrated. Activation of proteinase precedes chromosomal aberrations. Catepsin D activation is supposed to lead to proteolysis in achromatic apparatus which results in micronuclei formation.
Kliment'eva
T K
TK
Samoĭlova
O N
ON
Il'inskikh
N N
NN
D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D002402:Cathepsin D / Q000032:analysis*; D002869:Chromosome Aberrations; D004789:Enzyme Activation; D006854:Hydrocortisone / Q000494:pharmacology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D008168:Lung / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective
D007252:Influenza Vaccines; D000643:Ammonium Chloride; D002402:Cathepsin D; D006854:Hydrocortisone
Rol' katepsina D v induktsii mikroiader v kletkakh legkikh mysheĭ, immunizirovannykh vaktsinnym shtammom virusa grippa.