title: Regional cerebral blood flow in chronic alcoholics measured by single photon emission computerized tomography.
abstract: Regional cerebral blood flow (CBF) was measured by single photon emission computerized tomography of inhaled 133-Xe in 20 chronic alcoholic men. Mean CBF was 51 ml/(100 g x min) compared with 53 ml/(100 g x min) in 20 normals. Reduced cerebellar blood flow correlated both to structural abnormalities seen on CT scan and to cognitive dysfunction. Slight abnormalities of the regional CBF was observed in the alcoholics. They had a higher incidence of regional low flow areas than a control group. Low flow areas were found in frontal and posterior parts of the brain not only in patients with atrophia, but also in patients without CT abnormalities, suggesting neuronal dysfunction. The occurrence of regional low flow areas was associated with the severity of alcoholism, cerebral atrophy and intellectual impairment.
authors: Department of Neurology, Gentofte Hospital, Hellerup, Denmark.
authors: B
authors: B
authors: Melgaard
authors: L
authors: L
authors: Henriksen
authors: P
authors: P
authors: Ahlgren
authors: U T
authors: UT
authors: Danielsen
authors: H
authors: H
authors: Sørensen
authors: O B
authors: OB
authors: Paulson
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001284:Atrophy; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011581:Psychological Tests; D011897:Random Allocation; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D000431:Ethanol