Treatment of traumatic optic neuropathy with corticosteroids.
We treated 21 patients (22 eyes) with traumatic optic neuropathy by using intravenous megadose methylprednisolone (13 patients) or high-dose dexamethasone (eight patients). Of 13 patients treated with megadose methylprednisolone, 12 had improved visual function, as did seven of nine eyes treated with intravenous dexamethasone. This difference was not significant (P = .3). Initial total blindness, mechanism of injury, or time from injury to treatment did not correlate with visual improvement.
Spoor
T C
TC
Kresge Eye Institute, Wayne State University, Detroit, MI 48201.
Hartel
W C
WC
Lensink
D B
DB
Wilkinson
M J
MJ
D000293:Adolescent; D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D020221:Optic Nerve Injuries; D013997:Time Factors; D014792:Visual Acuity; D014794:Visual Fields
D003907:Dexamethasone; D008775:Methylprednisolone