[The free amino acid content of the blood serum in bladder cancer patients].
The content of 18 amino acids in the blood serum was studied in 57 patients with T2-4 carcinoma of the bladder according to the stage of the process and the functional condition of the kidneys. Dysaminoacidemia was found in patients with T2 bladder carcinoma, which did not need correction; marked hypoaminoacidemia was encountered in stage T3-4 tumors. Chronic renal insufficiency (intermittent and terminal stages) is conductive to significant decrease of the blood amino acid level. The content of amino acids is lower in the postoperative than in the preoperative period. The degree of reduction of the amino acid content in blood was found to be dependent on the volume of the operation. The reduction of the amino acid content is more intense after cystectomy than after resection of the bladder. Correction of the blood amino acid content in the preoperative period in patients with T3-4 carcinoma of the bladder reduces the incidence of postoperative complications. Correction of hypoaminoacidemia with polyamine proves effective in patients with maintained renal nitrogen excreting function. In development of azotemia in patients with bladder carcinoma, substitution transfusion therapy for correction of hypoaminoacidemia becomes effective only after restoration of the nitrogen excreting function of the kidneys.
Nechiporenko
N A
NA
Nefedov
L I
LI
Klimovich
I I
II
D000368:Aged; D000596:Amino Acids / Q000097:blood*; D015653:Cystectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
D000596:Amino Acids
Soderzhanie svobodnykh aminokislot v syvorotke krovi bol'nykh rakom mochevogo puzyria.