Evidence of heterogeneous mechanisms in lipoprotein lipid alterations in hyperandrogenic women.
Fifty-one hyperandrogenic women had their lipoprotein lipid profiles determined. Free and albumin-bound testosterone was associated with triglycerides and with high-density lipoprotein cholesterol independent of fasting insulin levels, percent ideal body weight, and waist/hip ratio. To gain insight into mechanisms of these lipid alterations, the women were subgrouped according to apparent source of androgen excess. Whereas all groups had low levels of high-density lipoprotein-2 cholesterol and high triglyceride concentrations, only in those with high luteinizing hormone-to-follicle-stimulating hormone ratios was free and albumin-bound testosterone associated with triglycerides and high-density lipoprotein cholesterol independent of fasting insulin levels. Relationships between percent ideal body weight and waist/hip ratios, free and albumin-bound testosterone, sex hormone binding globulin, fasting insulin and 2-hour insulin levels and blood pressure are not significant in all subgroups, suggesting differing endocrinological influences and differing mechanisms for lipoprotein lipid alterations.
Wild
R A
RA
Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
Bartholomew
M
M
Applebaum-Bowden
D
D
Demers
L M
LM
Hazzard
W
W
Santen
R J
RJ
D000328:Adult; D000728:Androgens / Q000097:blood*; D005260:Female; D006628:Hirsutism / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000728:Androgens; D007328:Insulin; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D013739:Testosterone