Hyponatremia in spinal cord injury.
Hypoosmolar hyponatremia (serum Na+ less than 130 mmol/L) has proven a common and incompletely explained phenomenon in the spinal cord injured patient. When present, it has generally been preceded by excessive fluid intake and environmental/dietary factors which reversibly restrict free water excretion. We have attempted to more fully characterize the determinants of SCI-associated hyponatremia by retrospectively analyzing its features and treatment response in a series of 14 hyponatremic SCI patients. In most instances, hyponatremia could be attributed to uncontrolled fluid intake in the presence of an acute or semiacute illness and thus stimuli for non-osmotic releases of arginine vasopressin. Treatment measures generally included administration of 3% saline, with all patients recovering uneventfully from their episode of hyponatremia.
Sica
D A
DA
Department of Medicine, Medical College of VA, Richmond 23298-0160.
Midha
M
M
Zawada
E
E
Stacy
W
W
Hussey
R
R
D000328:Adult; D000368:Aged; D004326:Drinking / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007010:Hyponatremia / Q000503:physiopathology* / Q000628:therapy; D007671:Kidney Concentrating Ability / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012964:Sodium / Q000097:blood; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D012462:Saline Solution, Hypertonic; D012964:Sodium