[Plasma histamine and exercise-induced bronchospasm].
The pathogenesis of bronchospasm of effort is not yet elucidated and it is probable that is determined by multiple factors. In this study we have tested the role of mastocytes in taking as an index of their activation the fluctuation of plasma histamine levels during repeated exercise tests. We will show that asthmatic subjects who develop bronchospasm on effort have a significant rise (times 3) in their level of serum histamine whilst normal subjects don't show much change. Furthermore in a repeated effort test we have observed a strict parallelism between the occurrence of bronchospasm of effort and a rise in plasma histamine levels. These different observations enable us to consider that the activation of mastocytes and the liberation of mediators which follow play an important role in the pathogenesis of bronchospasm of effort.
Bury
T
T
Service de Pneumologie, CHU Liège, Sart Tilman, Belgique.
Pirnay
F
F
Corhay
J L
JL
Bartsch
P
P
Radermecker
M F
MF
D000293:Adolescent; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000097:blood* / Q000209:etiology / Q000276:immunology; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test; D006632:Histamine / Q000097:blood*; D006801:Humans; D008407:Mast Cells / Q000276:immunology; D008448:Maximal Expiratory Flow Rate
D006632:Histamine; D004837:Epinephrine
Histamine plasmatique et bronchospasme d'effort.