A double-blind comparison of intranasal budesonide with placebo for nasal polyposis.
Intranasal budesonide, 400 micrograms two times a day, was evaluated in 36 patients referred for treatment of nasal polyposis. The age range was 20 to 68 years. Polypectomy was done 5.6 (mean) times previously. After a 5-week, treatment-free, baseline period, patients were treated in a double-blind fashion with either budesonide or placebo during 4 weeks. After this treatment period, placebo-treated patients started receiving budesonide in an open trial for an additional 4 weeks. The patients rated their nasal symptoms daily. Nasal examinations and nasal inspiratory flow rate (IFR) measurements were done at clinic visits. After 3 and 4 weeks of treatment, the response to budesonide was significantly greater than response to placebo. The greater reduction in nasal blockage caused by polyps, observed on physical examination, p = 0.005, was mirrored by an increase in nasal IFR (p = 0.0001). Patient rating of the severity and frequency of nasal blockage were reduced more by budesonide than by placebo (p less than or equal to 0.0005). Switching placebo-treated patients to budesonide treatment resulted in a reduction of nasal blockage (p less than 0.001) and an increase in nasal IFR (p less than 0.001). The results demonstrate that topical nasal budesonide, 400 micrograms two times a day, is an effective treatment of nasal polyps.
Ruhno
J
J
Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Andersson
B
B
Denburg
J
J
Anderson
M
M
Hitch
D
D
Lapp
P
P
Vanzieleghem
M
M
Dolovich
J
J
D000281:Administration, Intranasal; D019819:Budesonide; D004311:Double-Blind Method; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D009298:Nasal Polyps / Q000188:drug therapy* / Q000503:physiopathology; D010349:Patient Compliance; D010919:Placebos; D011282:Pregnenediones / Q000009:adverse effects / Q000627:therapeutic use*; D012123:Pulmonary Ventilation
D005938:Glucocorticoids; D010919:Placebos; D011282:Pregnenediones; D019819:Budesonide