Moclobemide versus clomipramine in the treatment of depression: a single-centre study, Federal Republic of Germany.
Moclobemide was compared with clomipramine for safety and efficacy in 2 groups of 15 patients each with endogenous depression. The drugs were given under double-blind conditions in increasing doses; 1 patient in the moclobemide group dropped out because of lack of efficacy. Mean final improvement on the Hamilton Rating Scale for Depression was 51% in the moclobemide group and 54% in the clomipramine group. Efficacy and tolerance were rated good or very good by 47% (moclobemide) and 53% (clomipramine) (NS). The results indicate that moclobemide is as effective as clomipramine in treating endogenous depression.
Funke
H J
HJ
Alsterdorfer Anstalt, Hamburg, Federal Republic of Germany.
Moritz
E
E
Hellstern
K
K
Malanowski
H
H
D000928:Antidepressive Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005858:Germany; D006801:Humans; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
D000928:Antidepressive Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D002997:Clomipramine; D020912:Moclobemide