Appendicitis in children: current therapeutic recommendations.
Wound infection is the most common source of morbidity in appendicitis. Most recent pediatric series use protocols of preoperative antibiotics with aerobic and anaerobic coverage, intraoperative lavage, no peritoneal or wound drains, and continuation of antibiotics postoperatively with complicated appendicitis. There still remains controversy concerning skin closure and the duration of antibiotic therapy. We report the results of a prospective protocol followed over 2 years with 420 children. The protocol was designed to determine whether the skin could be closed primarily in all patients undergoing appendectomy. Preoperatively all patients received triple antibiotics (ampicillin, gentamicin, and clindamycin) that were continued postoperatively for two doses if there was a normal appendix or simple acute appendicitis, for at least 3 days with gangrenous appendicitis, and at least 5 days with perforated appendicitis. Antibiotics were continued if the patient remained febrile or had a white count greater than 10,000. No drains were used and the skin was closed primarily. The overall infectious complication rate was 1.0% (4/420). Among those with a normal appendix or simple acute appendicitis there were no infectious complications. Among those with gangrenous or perforated appendicitis there were 1.7% wound infections (2/117) and 1.7% intraabdominal abscesses (2/117). Duration of hospitalization was 2.1 days (range, 1 to 5 days) after simple acute appendicitis and 6.9 days (range, 3 to 40 days) after gangrenous or perforated appendicitis. These results set new standards in terms of wound management, infectious complications, and length of hospital stay.
Neilson
I R
IR
Department of Pediatric Surgery, Montreal Children's Hospital, Quebec, Canada.
Laberge
J M
JM
Nguyen
L T
LT
Moir
C
C
Doody
D
D
Sonnino
R E
RE
Youssef
S
S
Guttman
F M
FM
D000293:Adolescent; D000900:Anti-Bacterial Agents; D001062:Appendectomy; D001064:Appendicitis / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004322:Drainage; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004630:Emergencies; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007902:Length of Stay; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents