[Morpho-functional characteristics of lymph nodes in mice of different strains after administration of immunomodulators].
Using certain histological and morphometrical methods, cytoarchitectonics of T- and B-zones in the iliac lymph nodes have been studied with a simultaneous embryometry at a physiological pregnancy and under conditions of immunomodulators (IM) administration. The degree of influence of IM changes in the raw polysaccharide++-conjugate-polyelectrolite. Mass of the lymph nodes studied under effect of polyelectrolite becomes greater. Polyelectrolite and conjugate stimulate essentially the hormonal link of immunity and activate the system of mononuclear phagocytes. Morphofunctional state of the iliac lymph node changes more considerably at polyelectrolite administration and somewhat less--at conjugate, with the greatest degree in pregnant mice, in comparison with nonpregnant ones. The IM produce hypertrophy of the lymph node, making a stimulating effect in lymphatic nodules++, paracortical zone cortical plateau, medullary cords, medullary intermediate sinus, as well as in cellular reactions (blast transformation++, amount of macrophages and plasma cells having various degree of differentiation, bi- and multinuclearity). Parallelizm between rearrangement degree of the iliac lymph node, administration of the synthetic IM and growth of the fetus mass has been revealed. This stresses the volume of reserved plastic properties of the lymph node and possibility to make longer the period of its greatest activity up to termination of pregnancy when IM are introduced. Pregnancy is a sensibilizing factor, which intensifies (or prolongates) the reaction of T- and B-zones in the lymph node and its cell composition. IM, altering the maternal immunological status, produce certain changes in the fetus mass.
Borodin
Iu I
IuI
Sklianova
N A
NA
Sklianov
Iu I
IuI
Patrusheva
S V
SV
D000180:Acrylic Resins / Q000008:administration & dosage*; D000276:Adjuvants, Immunologic; D000818:Animals; D005260:Female; D005333:Fetus / Q000166:cytology* / Q000276:immunology; D007114:Immunization; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D011205:Povidone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D011247:Pregnancy / Q000276:immunology*; D012486:Salmonella typhimurium
D000180:Acrylic Resins; D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; C043348:acrylic acid-N-vinylpyrrolidone copolymer; D011205:Povidone
Morfofunktsional'naia kharakteristika limfaticheskikh uzlov u mysheĭ raznykh liniĭ pri vvedenii immunomoduliatorov.