title: Effect of digitalis on clinical symptoms and conduction variables in patients with multiple sclerosis.
abstract: Digitalis has been shown to reverse conduction block in demyelinated nerve fibers in experimental animals. In the search for a symptomatic treatment of multiple sclerosis, digoxin (0.02 mg per kilogram of body weight) was given intravenously to 7 patients with probable or clinically definite multiple sclerosis. All of these patients had temperature-dependent symptoms. In 3 patients, improvement of clinical deficits was observed concurrent with significant changes in evoked potential findings. Digitalis derivatives may be useful in ameliorating symptoms in selected patients with multiple sclerosis.
authors: Department of Neurology, Kyoto University Hospital, Japan.
authors: R
authors: R
authors: Kaji
authors: L
authors: L
authors: Happel
authors: A J
authors: AJ
authors: Sumner
mesh_terms: D000328:Adult; D004077:Digoxin / Q000494:pharmacology / Q000627:therapeutic use*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects*; D013696:Temperature
chemical_list: D004077:Digoxin