[The antiviral activity of a number of Soviet chemical preparations and the interferon inducer larifan and their combinations in a model of experimental genital herpes in guinea pigs].
Chemical drugs and the Soviet interferon inducer larifan as well as their combinations were evaluated in genital herpes in male guinea pigs. Among the chemical drugs tested, the highest efficacy was observed with 2% phosphonoformic acid trisodiate ointment (its therapeutic effect 62%). The efficacy of 2% cycloguanosine ointment and 0.5% phosphonoacetic ointment did not exceed 43% and 36%, respectively. Topical and systemic use of the interferon inducer larifan produced a marked therapeutic effect (63%). Combined use of purophosphate and cycloguanosine analogues was more effective than the agents alone, yet the effect of the combinations being nothing more than additive.
L'vov
N D
ND
Samoĭlovich
E O
EO
Tikhonchuk
I A
IA
Vanag
A I
AI
Lidak
M Iu
MIu
Chepaĭkina
T A
TA
Tsvetkov
E N
EN
Barinskiĭ
I F
IF
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D013997:Time Factors
D000998:Antiviral Agents; D007369:Interferon Inducers; D012330:RNA, Double-Stranded
Protivovirusnaia aktivnost' riada otechestvennykh khimiopreparatov: induktora interferona larifana i ikh komboinatsiĭ na modeli éksperimental'nogo genital'nogo gerpesa morskikh svinok.