Mutagenicity of vinyl chloride in man: comparison of chromosome aberrations with micronucleus and sister-chromatid exchange frequencies.
The mutagenic effects of vinyl chloride monomer in man were studied in the lymphocyte culture with 3 methods: the chromosome aberration assay, the micronucleus assay and the sister-chromatid exchange method. Compared with control, values obtained by these tests are increased in workers occupationally exposed to vinyl chloride. In relation to non-smokers, smokers exposed to vinyl chloride show significant increases in sister-chromatid exchange frequencies. The problem of correlating the results of the chromosome aberration assay with micronucleus and sister-chromatid exchange frequencies is discussed.
Fucić
A
A
Institute for Medical Research and Occupational Health, Zagreb, Yugoslavia.
Horvat
D
D
Dimitrović
B
B
D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D008875:Middle Aged; D009153:Mutagens; D016273:Occupational Exposure; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012907:Smoking / Q000235:genetics; D014752:Vinyl Chloride / Q000633:toxicity*
D009153:Mutagens; D014752:Vinyl Chloride