Cytokines and anticytokines.
The inflammation in the rheumatoid synovial membrane may be characterised by the concomitant presence of proinflammatory and anti-inflammatory mechanisms and mediators. These events may be spacially distributed within the tissue and may be visualised as waves of inflammation followed by waves of repair. The aim of therapy must be to enhance the anti-cytokine and reoperative processes over the inflammatory ones.
Panayi
G S
GS
United Medical School, Guy's Hospital, London, UK.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000503:physiopathology*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000502:physiology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D008233:Lymphotoxin-alpha / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D016207:Cytokines; D007375:Interleukin-1; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha