[Comparative ability of three aniline derivatives to alter biotransformation enzymes in rat liver].
The effect of 4,4'-methylene bis (2-chloroaniline) (MOCA), 4,4'-methylene dianiline (MDA) and 4,4'-sulfonyl dianiline (Dapsone) on xenobiotic biotransformation in vivo was studied in male rat liver. Treatment with MOCA and MDA caused a dose dependent increase in ethoxyresorufin O-deethylase activity and concomitant decrease in aldrin epoxidase activity. Treatment with MOCA and MDA also resulted in increases in ethoxycoumarin O-deethylation and epoxide hydrolation while only MOCA induced cytosolic glutathione S-transferase activity. Treatment with Dapsone resulted in no changes in xenobiotic biotransformation except for the induction of aniline hydroxylation. The results are consistent with the contention that there is a relationship between carcinogenic chemicals and particular alteration in the activities of biotransformation enzymes.
Wu
K
K
School of Public Health, Haerbin Medical University.
D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003622:Dapsone / Q000633:toxicity*; D005982:Glutathione Transferase / Q000378:metabolism*; D008297:Male; D008753:Methylenebis(chloroaniline) / Q000633:toxicity*; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D001559:Benzhydryl Compounds
D000814:Aniline Compounds; D003577:Cytochrome P-450 Enzyme System; D003622:Dapsone; D005982:Glutathione Transferase; D008753:Methylenebis(chloroaniline); C009505:4,4'-diaminodiphenylmethane; D001559:Benzhydryl Compounds