[Exudative enteropathy and interstitial cystitis due to systemic lupus erythematosus].
A 33-year-old woman presented with chronic diarrhea, vomiting and anasarca due to systemic lupus erythematosus with protein-losing enteropathy, interstitial cystitis and glomerulonephritis. Methylprednisolone could not prevent aggravation of diarrhea, obstructive uropathy, and nephrotic syndrome, and prolonged intestinal ileus developed. Because of this steroid-resistance, bolus injections of cyclophosphamide (1 g i.v. monthly) were decided. Protein-losing enteropathy and ileus both disappeared rapidly following the first injection. Protein-losing enteropathy, intestinal ileus and interstitial cystitis are exceptional manifestations of systemic lupus erythematosus; steroid-resistance of the digestive manifestations has only been reported in one case and our observation is the first reporting the efficacy of cyclophosphamide.
Marteau
P
P
Cliique d'Hépato-Gastroentérologie, Hôpital Saint-Antoine, Paris.
Grange
J D
JD
Michel
C
C
Mosnier
J F
JF
Islam
S
S
Najman
A
A
Mignon
F
F
Bodin
F
F
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003556:Cystitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000209:etiology*; D014567:Urography
D003520:Cyclophosphamide
Entéropathie exsudative et cystite interstitielle au cours d'un lupus érythémateux disséminé.