Inhibition of rat hepatic glutathione S-transferase placental form positive foci development by concomitant administration of antioxidants to carcinogen-treated rats.
Inhibition potential of concomitant butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), catechol or sodium ascorbate (Na-AsA) administration on development of diethylnitrosamine (DEN) initiated glutathione S-transferase placental form (GST-P) positive foci in rat liver under the influence of 2-acetylaminofluorene (2-AAF) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) plus partial hepatectomy (PH) was investigated. Whereas BHA, BHT and catechol exerted marked inhibitory effects, Na-AsA lacked any modifying potential. The compounds that demonstrated inhibition also induced GST-P in the hepatic periportal areas, suggesting that development of GST-P positive foci is negatively influenced by extra-focal increase in this enzyme form observed with BHA, BHT or catechol.
Asamoto
M
M
First Department of Pathology, Nagoya City University Medical School, Japan.
Shichino
Y
Y
Tsuda
H
H
Ito
N
N
D015073:2-Acetylaminofluorene; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D002396:Catechols / Q000494:pharmacology*; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D005982:Glutathione Transferase / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D051381:Rats; D011916:Rats, Inbred F344
D002396:Catechols; D002083:Butylated Hydroxyanisole; D004052:Diethylnitrosamine; D008749:Methyldimethylaminoazobenzene; D015073:2-Acetylaminofluorene; D005982:Glutathione Transferase; C034221:catechol; D001205:Ascorbic Acid