Antifertility effects of leaf extracts of some plants in male rats.
Ethanolic leaf extracts of different local folklore plants (Azadirachta indica, Beaumontia grandiflora, Chordia dichotoma, Casiarea tomentosa, Diospyros embryopteris, Milletia auriculata and Melia azedarach) were investigated for antifertility effects on male rats in oral doses of 100 mg/kg daily for 21 days. Though, none of these extracts interfered with spermatogenesis, anti-implantational and abortifacient effects were observed in females mated by the males fed with leaf extracts of A. indica and C. dichotoma. Leaf extract of B. grandiflora besides having anti-implantational and abortifacient effects, had luteolytic effects. Abolition of libido in 100% males by leaf extracts of D. embryopteris and M. azedarach and in 60% of males by extract of C. tomentosa preclude these plants for antifertility use.
Choudhary
D N
DN
University Department of Botany, Bhagalpur University, India.
Singh
J N
JN
Verma
S K
SK
Singh
B P
BP
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007989:Libido / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects
D003272:Contraceptive Agents, Male; D010936:Plant Extracts