The syndrome of Möbius sequence, peripheral neuropathy, and hypogonadotropic hypogonadism.
We report on a 17-year-old Japanese boy with Möbius sequence, peripheral neuropathy, and hypogonadotropic hypogonadism, the fourth such case known to us. The association of peripheral neuropathy and hypogonadotropic hypogonadism in Möbius sequence seems to be more than coincidence. Pulsatile gonadotropin-releasing hormone administration for 3 months showed the effectiveness of this treatment for this patient.
Kawai
M
M
Department of Pediatrics, Kyoto University Faculty of Medicine, Japan.
Momoi
T
T
Fujii
T
T
Nakano
S
S
Itagaki
Y
Y
Mikawa
H
H
D000293:Adolescent; D003389:Cranial Nerve Diseases / Q000150:complications / Q000151:congenital*; D005158:Facial Paralysis / Q000150:complications / Q000151:congenital*; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000151:congenital* / Q000188:drug therapy; D008297:Male; D009886:Ophthalmoplegia / Q000150:complications / Q000151:congenital*; D013739:Testosterone / Q000097:blood
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone