Coagulation impact on chemotactic activity generation for polymorphonuclear leukocytes.
Chemotactic technique in agarose gel has exposed the attractive properties of human alpha thrombin with respect to human polymorphonuclear leukocytes. The observed chemotaxis is maximal between 1.4.10-5 M and 1.6.10-5 M but extends from 2.8.10-6 M to 2.2.10-5 M. Human prothrombin, in an identical concentration zone as that studied for thrombin shows no chemotactic activity on the polymorphonuclear leukocytes. During coagulation the formed alpha thrombin attracts the polymorphonuclear leukocytes to it's formation site.
Morin
A
A
Centre de Transfusion Sanguine, Vandoeuvre, France.
Arvier
M M
MM
Doutremepuich
F
F
Vigneron
C
C
D002630:Chemotactic Factors / Q000096:biosynthesis*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D006801:Humans; D009504:Neutrophils / Q000502:physiology; D011516:Prothrombin / Q000502:physiology*; D013917:Thrombin / Q000502:physiology*
D002630:Chemotactic Factors; D011516:Prothrombin; D013917:Thrombin