[Transplacental administration of diethylstilbestrol in the rat. II. Effect on the hormonal receptors of the endometrium].
Transplacental exposure to diethylstilboestrol (DES) strongly decreases the fertility of the offsprings. Progesterone receptors concentrations are significantly decreased for treated group (0.40 and 0.44 pmol/mg cytosol proteins) versus control group (0.74 pmol/mg cytosol proteins) Estradiol receptor concentrations are significantly higher for long time treated groups (0.26 pmol/mg cytosol proteins) versus control or short time treated groups (0.15 and 0.13 pmol/mg cytosol proteins).
Cognat
M
M
Service de Gynécologie-Andrologie, Hôpital Saint-Joseph, Lyon.
Rachail
M
M
Terpou
A
A
Deschanel
J P
JP
D000818:Animals; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000494:pharmacology*; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D004054:Diethylstilbestrol
Administration transplacentaire de diéthylstilboestrol chez le rat. II. Effets sur les récepteurs hormonaux de l'endomètre.