[Age-dependent characteristics of metabolism of DNA precursors in healthy women, patients with mastopathy and breast cancer].
Activities of thymidine kinase, thymidine phosphorylase, adenosine deaminase and 5'-nucleotidase of AMP were studied in blood serum and lymphocytes of healthy women, patients with mastopathy and with mammary gland cancer of 23-70 years old. Age-dependent alterations in the enzymatic activity were detected in blood serum of healthy women. Activity of thymidine kinase was increased simultaneously with a decrease in thymidine phosphorylase activity in 36-70 years old oncological patients, while adenosine deaminase activity was increased in patients with mastopathy and with mammary gland cancer of all the age groups. Dynamics of the enzymatic activity studied before and during chemotherapeutic treatment may be used as one of biochemical tests for evaluation of the therapy efficiency in oncological patients.
Borzenko
B G
BG
D015720:5'-Nucleotidase / Q000097:blood / Q000378:metabolism; D000243:Adenosine Deaminase / Q000097:blood / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D004247:DNA / Q000097:blood / Q000378:metabolism*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009694:Nucleic Acid Precursors / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D013937:Thymidine Kinase / Q000097:blood / Q000378:metabolism; D013939:Thymidine Phosphorylase / Q000097:blood / Q000378:metabolism
D009694:Nucleic Acid Precursors; D004247:DNA; D013939:Thymidine Phosphorylase; D013937:Thymidine Kinase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase
Vozrastnye osobennosti metabolizma predshestvennikov DNK v organizme zdorovykh zhenshchin, bol'nykh mastopatieĭ i rakom molochnoĭ zhelezy.