Reversible oedema and necrosis after irradiation of the brain. Diagnostic procedures and clinical manifestations.
One hundred and twelve patients with primary brain tumour were followed every 3 months during and after brain irradiation and chemotherapy with brain scanning, EEG and neurological examination. Early delayed radiation reactions were seen in 6 patients. The symptoms developed 2-8 months after irradiation and lasted for 2-3 months. Two types of reactions were observed. One mild form appeared after 2-3 months and was characterized by low-attenuated expansive areas within the irradiated volume, without contrast enhancement on CT scan. Severe reactions appeared in some patients after 6 months, with exacerbation of earlier clinical signs and contrast enhancing lesions on CT. Regression of the CT finding was seen after 3 months. Recognition of this syndrome is important, as a new neurosurgical procedure might cause lasting neurological sequelae in patients who otherwise would recover without treatment.
Watne
K
K
Department of Oncology, Norwegian Radium Hospital, Oslo.
Hager
B
B
Heier
M
M
Hirschberg
H
H
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology*; D001932:Brain Neoplasms / Q000532:radiotherapy; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011878:Radiotherapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed