The migration of tobacco-specific nitrosamines into the saliva of chewers of nicotine-containing chewing gum.
In many countries nicotine-containing chewing gum (Nicorette) is used to help to break the habit of smoking. Saliva was collected every 5 min from chewers of nicotine chewing gum and analysed for tobacco-specific nitrosamines. Detectable levels of tobacco-specific nitrosamines were found in all samples collected between 5 and 15 min after chewing had started. The levels of N'-nitrosonornicotine ranged from 0.4 to 19 ng/g of saliva and those for the sum of N'-nitrosoanatabine plus N'-nitrosoanabasine from 1.3 to 46 ng/g. 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone was not detected in the saliva. The nicotine chewing gum was found to contain up to 380 ng tobacco-specific nitrosamines/g of chewing gum.
Osterdahl
B G
BG
Swedish National Food Administration, Uppsala.
D000328:Adult; D002273:Carcinogens / Q000032:analysis*; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D009602:Nitrosamines / Q000032:analysis*; D011109:Polymethacrylic Acids / Q000032:analysis / Q000378:metabolism*; D011145:Polyvinyls / Q000032:analysis / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D061485:Tobacco Use Cessation Devices
D002273:Carcinogens; D009602:Nitrosamines; D011109:Polymethacrylic Acids; D011145:Polyvinyls; C010257:N'-nitrosoanabasine; D009538:Nicotine; C032978:N'-nitrosoanatabine; C008655:N'-nitrosonornicotine