[Anti-arrhythmic effect of adaptative activation of the vagus nerve system and a new synthetic acetylcholine analog].
A higher vagal tone or its stimulation under certain conditions is known to increase the threshold of cardiac fibrillation and even to arrest developing arrhythmias. This effect is usually evaluated as a result of limiting the excessive adrenergic effect on the heart, which is observed in stress and ischemia. The following two facts have been first identified: 1) adaptation to moderate continuous stress may induce tonic excitation of parasympathetic regulation of the heart and enhance its resistance to ischemic and reperfusion arrhythmias; 2) this antiarrhythmic effect is completely reproducible by the recently synthesized acetylcholine analogue EDIHYP, ethyl-3/2-ethyl-2,2-dimethylhydrazinium/propionate iodate.
Meerson
F Z
FZ
Abdikaliev
N A
NA
Kuznetsov
V I
VI
Kalvin'sh
I Ia
IIa
D000109:Acetylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000220:Adaptation, Biological; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D000109:Acetylcholine
Antiaritmicheskiĭ éffekt adaptatsionnoĭ aktivatsii sistemy bluzhdaiushchego nerva i novogo sinteticheskogo analoga atsetilkholina.