Effect of bis(bilato)-1,2-cyclohexanediammineplatinum(II) complexes on lung metastasis of B16-F10 melanoma cells in mice.
New platinum(II) complexes, bis(bilato)-1,2-cyclohexanediammineplatinum(II) which were lipophilic and water-miscible, were tested for antitumor activity against lung nodules from intravenously injected B16-F10 melanoma cells in C57BL/6 mice by intravenous administration of the complexes in water suspension form. Among them, DACHP(litho)2 and DACHP(urso)2 had high antitumor activity but others had no activity. The antitumor activity of DACHP(urso)2 was increased significantly by injecting it three times; T/C was over 280% with 100-day survivors of 3 of 6 mice tested. Large amounts of total platinum were found in lung and liver tissues by atomic absorption spectroscopy after single intravenous injection of DACHP(urso)2 suspension in ICR mice.
Maeda
M
M
Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
Suga
T
T
Takasuka
N
N
Hoshi
A
A
Sasaki
T
T
D000818:Animals; D003514:Cyclohexylamines / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010984:Platinum / Q000493:pharmacokinetics; D012996:Solutions; D014018:Tissue Distribution
D003514:Cyclohexylamines; D009944:Organoplatinum Compounds; D012996:Solutions; D010984:Platinum