[Early diagnosis of nephropathy in type I diabetics].
In 68 type I diabetics without permanent proteinuria, mean age 28 +/- 9 years, where diabetes was detected at the age of 14 +/- 7 years and persists for 14 +/- 8 years the urinary excretion of albumin and beta-2-microglobulin was assessed. The results were evaluated in relation to the persistence of diabetes, the blood pressure reading, family-history of diabetes and type of insulin therapy. In addition to microalbuminuria in 29% of the subjects which is a manifestation of glomerular damage, the authors detected in 58% elevated beta-2-microglobulin excretion indicating early changes of the proximal tubule. There was a relationship between microalbuminuria and "relative hypertension" which enhances albumin excretion and increases the risk of diabetic nephropathy. The relationship between microalbuminuria and a positive family-history of diabetes supports the hypothesis of a genetic background for the possible development of nephropathy. There was also a relationship with the duration of diabetes and the favourable effect of prolonged intensive insulin treatment. The clinical impact of beta-2-microglobulinuria in the diagnosis of the incipient stage of diabetic nephropathy must be tested in future investigations.
Polácková
H
H
Interní klinika fakulty dĕtského lékarství Univerzity Karlovy, Praha.
Platilová
H
H
Dvoráková
L
L
Hájková
E
E
Nedvídková
J
J
Stolba
P
P
D000328:Adult; D000419:Albuminuria; D003922:Diabetes Mellitus, Type 1 / Q000652:urine; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin
Casná diagnostika nefropatie u diabetiků I. typu.