title: In vitro kinetics of the oxidative reactivity of nitrate and nitrite in the rat erythrocyte.
abstract: Isolated rat erythrocytes were incubated in the presence of nitrate and nitrite. Glucose, lactate, reduced glutathione, methaemoglobin, malondialdehyde and Na+/K+ membrane exchange were investigated. Nitrite induced a strong methaemoglobinaemia and a net depletion of reduced glutathione in the intracellular medium associated with membrane lipid peroxidation. This oxidative reactivity induced by nitrate and nitrite altered the cell's ionic flux.
authors: Université P. Sabatier, Institut de Physiologie, INSERM U-87, Toulouse, France.
authors: P
authors: P
authors: Batina
authors: P
authors: P
authors: Fritsch
authors: G
authors: G
authors: de Saint Blanquat
authors: M T
authors: MT
authors: Mitjavila
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D007773:Lactates / Q000096:biosynthesis; D008297:Male; D009566:Nitrates / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
chemical_list: D007773:Lactates; D009566:Nitrates; D009573:Nitrites; D012964:Sodium; D005947:Glucose; D011188:Potassium