title: Elevated hepatic mitochondrial oxidative capacities in cold exposed rats.
abstract: 1. Hepatic mitochondrial oxidative capacities were studied in rats exposed to cold for periods ranging from 5 to 15 days. The mitochondria obtained in this study were well coupled as shown by RCR and ADP/O ratios. 2. The liver mitochondria of cold exposed rats showed significantly increased respiratory rates (ng atoms of oxygen consumed min-1 mg prot-1), starting from day 10 of cold exposure, using lipid and non-lipid substrates. 3. For non-lipid substrates, the elevated respiratory rates found in the mitochondria could indicate an increased capacity to oxidize these substrates. For the lipid substrate, on the other hand, an enhanced oxidation through Krebs-cycle of a part of acetyl-CoA otherwise utilized to form ketone bodies, could also occur. 4. Taken together the results suggest that, during cold exposure, liver mitochondria could participate in cold adaptation mechanisms, by improving ATP production.
authors: Department of General and Environmental Physiology, University of Naples, Italy.
authors: G
authors: G
authors: Liverini
authors: F
authors: F
authors: Goglia
authors: A
authors: A
authors: Lanni
authors: S
authors: S
authors: Iossa
authors: A
authors: A
authors: Barletta
mesh_terms: D000064:Acclimatization / Q000502:physiology; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D003080:Cold Temperature; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000255:Adenosine Triphosphate