Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal fluid S-adenosylmethionine declines with age in humans.
Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate were measured in 80 children and young adults in whom there was no disturbance of the methyl transfer pathway. Cerebrospinal fluid was collected under standardized conditions and analyzed by high-performance liquid chromatography. S-Adenosylmethionine, but not methionine nor 5-methyltetrahydrofolate, concentrations declined sharply during the first year of life. There was no correlation between concentrations of S-adenosylmethionine and methionine or 5-methyltetrahydrofolate. Reference ranges for the three metabolites are given.
Surtees
R
R
Department of Child Health, Institute of Child Health, London, United Kingdom.
Hyland
K
K
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008715:Methionine / Q000134:cerebrospinal fluid*; D012436:S-Adenosylmethionine / Q000134:cerebrospinal fluid*; D013763:Tetrahydrofolates / Q000134:cerebrospinal fluid*
D013763:Tetrahydrofolates; D012436:S-Adenosylmethionine; D008715:Methionine; C005984:5-methyltetrahydrofolate