Impairment of ATP-linked reactions in mitochondria isolated from skeletal muscle of halothane-sensitive pigs.
Oxygen consumption was depressed in mitochondria isolated from halothane sensitive pig (HP) muscle. The calculation of the respiratory control ratio (RCR) indicated that mitochondria were more affected at the site-I level of the respiratory chain. Calcium accumulation in these mitochondria was not altered when driven by the oxidation of succinate. This process was abolished when linked to ATP as a source of energy. ATP transport was completely inhibited in (HP) mitochondria.
Ayoub
S
S
Institut National de Recherche Agronomique (INRA), Ceyrat, France.
Monin
G
G
Rock
E
E
Younes
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006221:Halothane / Q000009:adverse effects*; D066298:In Vitro Techniques; D008931:Mitochondria, Muscle / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D013552:Swine
D000255:Adenosine Triphosphate; D006221:Halothane