title: Clinical results and the Essen concept of TBI.
abstract: Total body irradiation (TBI) prior to bone marrow transplantation (BMT) is applied for treatment of 230 patients in the period 1975-1988. The clinical results of 169 patients treated by four different TBI dosage and treatment techniques are analysed. The risk of leukemic relapse is low after fractionated TBI (9%) as well as after single dose TBI (14%). The lowest frequency of interstitial pneumonitis (21%) occurred when the patient translation technique was used for fractionated homogeneous pa/ap TBI with 10 Gy (8 Gy lung dose) in 4 fractions in 4 days. Prophylaxis of GVHD and the modus of protective environment were two other factors which influence the risk of IP.
authors: Department of Radiotherapy, West German Tumour Centre, University Hospital, Essen.
authors: M
authors: M
authors: Molls
authors: U
authors: U
authors: Quast
authors: U W
authors: UW
authors: Schaefer
authors: D
authors: D
authors: Szy
authors: D W
authors: DW
authors: Beelen
authors: K
authors: K
authors: Quabeck
authors: U
authors: U
authors: Graeven
authors: H G
authors: HG
authors: Sayer
authors: M
authors: M
authors: Bamberg
authors: H
authors: H
authors: Sack
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000532:radiotherapy* / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000453:epidemiology; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*