title: [Pump function of the left ventricle during the stages of cor pulmonale development].
abstract: Cluster analysis was used to examine the nature and magnitude of changes in left ventricular pump function in relation to the severity of primary bronchial obstruction in patients with non-atopic bronchial asthma (n = 45) and chronic obstructive bronchitis (n = 45). In the patients with obstructive lung disease, central hemodynamic changes were found to be determined by the bronchial patency and independent of the pathogenesis of the obstruction. During a remission there was a significant reduction in total peripheral resistance as compared to the values seen in healthy subjects, whereas in moderate or severe obstruction there was a marked increase in total peripheral resistance and a decrease in stroke volume and cardiac output. A drastic bronchial obstruction was followed not only by central hemodynamic changes, but a fall in ejection fraction and a rise in left ventricular end-systolic and end-diastolic volumes.
authors: S A
authors: SA
authors: Pavlishchuk
authors: Iu S
authors: IuS
authors: Kokarev
authors: T Iu
authors: TIu
authors: Lushpaĭ
authors: Al'-Farra Riad Mokhammed
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001991:Bronchitis / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D009200:Myocardial Contraction; D011660:Pulmonary Heart Disease / Q000209:etiology*
vernacular_title: [Nasosnaia funktsiia levogo zheludochka na étapakh formirovaniia legochnogo serdtsa]