[Treatment of tuberculosis. Drug combinations, therapeutic problems and results in a 10-year case load].
The article describes the treatment of tuberculosis in 426 patients over a period of ten years. The length of treatment decreased during the period. The standard treatment was isoniazide and rifampicin, usually with initial administration of pyrazinamide. In pulmonary tuberculosis (n = 334) the median bacteriologic conversion time was five weeks. In 69 patients the medical regimen had to be changed because of side effects. Of the primary antituberculous drugs, isoniazide was the one producing the highest frequency of side effects. 31 patients showed lowered sensitivity to the usual antituberculous drugs and were treated with varying combinations of second line drugs. In two cases surgery was necessary in order to achieve bacteriologic conversion. Ten patients died of tuberculosis in spite of treatment. Five patients with pulmonary tuberculosis suffered a relapse after treatment. No relapse was noted among patients with extrapulmonary tuberculosis. There were large differences between the different pulmonary treatment centres in Eastern Norway as regards how they practised the Norwegian control routines.
Morland
L
L
Glittre Sanatorium.
D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D011718:Pyrazinamide / Q000008:administration & dosage / Q000009:adverse effects; D012008:Recurrence; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin
Behandling av tuberkulose. Medisinkombinasjoner, behandlingsproblemer og resultater i et tiårsmateriale.