[Comparative study of the effectiveness of amikacin and streptomycin in experimental tularemia].
In vitro study on antibacterial activity of amikacin in comparison to that of streptomycin revealed a high sensitivity of tularemia microbes of three geographical races to it. Amikacin showed a high therapeutic activity in treatment of albino mice infected with tularemia. The prospects of amikacin use in prophylaxis and treatment of tularemia are defined by its antibiotic activity against streptomycin-resistant forms of the tularemia causative agent.
Tynkevich
N K
NK
Pavlovich
N V
NV
Ryzhko
I V
IV
D000583:Amikacin / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003470:Culture Media; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D005604:Francisella tularensis / Q000187:drug effects*; D066298:In Vitro Techniques; D051379:Mice; D013307:Streptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D014406:Tularemia / Q000188:drug therapy* / Q000382:microbiology
D003470:Culture Media; D000583:Amikacin; D013307:Streptomycin
Sravnitel'noe izuchenie éffektivnosti amikatsina i streptomitsina pri éksperimental'noĭ tuliaremii.