[Assessment of the efficacy of treating infections in hematopoietic proliferative diseases: Monotherapy with ceftazidime and tobramycin combined with amoxycillin/ampicillin].
Efficacy of the ceftazidime monotherapy in 120 febrile children with neoplastic diseases and granulocytopenia was compared with that of tobramycin combined with amoxycillin/ampicillin. The obtained results were similar in both types of antibiotic therapy. However, granulocytopenia was higher and septicemia was more frequent in children treated with ceftazidime. Isolated bacteria were more sensitive to ceftazidime than to tobramycin with amoxycillin/ampicillin. Both regimens were tolerated well. Despite a low number of patients in both groups, one may conclude that ceftazidime is more efficient in patients with granulocytopenia. Less adverse reactions, lower number of infections, less frequent medical procedures, elimination of the potentially toxic aminoglycosides and lower cost of therapy advocate the use of ceftazidime monotherapy.
Koehler
M
M
I Katedry Pediatrii Sl. AM w Zabrzu.
Bubała
H
H
Sońta-Jakimczyk
D
D
Wieczorek
M
M
Janik-Moszant
A
A
Kuder
K
K
D000658:Amoxicillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002442:Ceftazidime / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications*; D014031:Tobramycin / Q000627:therapeutic use*
D000667:Ampicillin; D000658:Amoxicillin; D002442:Ceftazidime; D014031:Tobramycin
Ocena skuteczności leczenia zakazeń w przebiegu chorób rozrostowych układu krwiotwórczego: Monoterapia ceftazydymem i skojarzenie tobramycyny z amoksycylina/ampicylina.