[Genotoxicity of fried fish extract, MeIQ and inhibition by green tea antioxidant].
Fried fish extract (FFE) and its related compound MeIQ showed potent genotoxicity to mammalian cells. FFE and MeIQ induced an increase in SCE or micronuclei in V79 cells in the presence of S9mix and an increase in SCE in IAR20 cells without S9mix UDS of rat primary hepatocytes was also significantly increased after treatment by FFE or MeIQ. Green tea antioxidant strongly inhibited the increase in SCE and micronuclei induced by FFE or MeIQ in V79 or IAR20 cells. The inhibitory effect of antioxidant on UDS was also observed in rat primary hepatocytes treated with FFE or MeIQ. The results indicate that mutagens and/or carcinogens might be produced during cooking of meat under high temperature. Frequent intake of green tea might be beneficial to human health.
Liu
X L
XL
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D005399:Fishes; D006358:Hot Temperature; D008099:Liver / Q000166:cytology; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology; D011804:Quinolines / Q000633:toxicity*; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013662:Tea
D000975:Antioxidants; D009153:Mutagens; D010936:Plant Extracts; D011804:Quinolines; D013662:Tea; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline