Hematopoiesis on cellulose ester membranes (CEM). XII. Effect of membrane enrichment by purified matrix proteins.
Cellulose ester membranes (CEM) were enriched with the following purified matrix proteins: collagen I, II, IV, proteoglycan and laminin. Fifteen milligrams of each were placed on CEM which were then folded into open-ended tubes implanted i.p. and s.c. CEM were removed after 3, 6 and 12 months and examined histologically. There was no evidence of hematopoiesis or new bone formation on the implanted, enriched CEM at any of the intervals examined. Collagen I and proteoglycan-enriched CEM showed evidence of increased sinusoid-like vascular structures.
Knospe
W H
WH
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Husseini
S G
SG
Schwartz
D
D
D000818:Animals; D002482:Cellulose; D003094:Collagen / Q000494:pharmacology*; D004952:Esters; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D007797:Laminin / Q000494:pharmacology*; D008567:Membranes, Artificial; D051379:Mice; D008815:Mice, Inbred Strains; D011509:Proteoglycans / Q000494:pharmacology*
D004952:Esters; D007797:Laminin; D008567:Membranes, Artificial; D011509:Proteoglycans; D002482:Cellulose; D003094:Collagen