title: Quantitative variations in A, B, Ht1 and Ht2 antigens on erythrocytes in leukemia and lymphoma.
abstract: Using an immunoradiometric assay, A, B, Ht1 and Ht2 antigens on erythrocyte membranes were quantitated in 192 leukemia and 23 lymphoma patients. A and B antigens were reduced in 37% and 50% of leukemia cases respectively. A wide range of antigenic reduction was observed for A antigen, while B antigenic reduction was generally 16-20%. Passive absorption of Ht1 antigen from plasma onto erythrocytes was greater in leukemic compared to normal subjects. Among patients with reduced A and B antigens, 27% had increased and 37% decreased Ht2 antigens. Incidence of reduction in antigens was significantly higher (p less than 0.001) in untreated compared to treated patients.
authors: Institute of Immunohaematology (Indian Council of Medical Research), K.E.M. Hospital Parel, Bombay, India.
authors: A
authors: A
authors: Dumasia
authors: S
authors: S
authors: Gupte
authors: A
authors: A
authors: Dasgupta
authors: S
authors: S
authors: Advani
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004910:Erythrocyte Membrane / Q000276:immunology*; D006801:Humans; D015592:Immunoradiometric Assay; D007938:Leukemia / Q000097:blood*; D008223:Lymphoma / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values
chemical_list: D000017:ABO Blood-Group System; D001789:Blood Group Antigens