Beta-endorphin decline in late luteal phase dysphoric disorder.
The beta-endorphin hypothesis of late luteal phase dysphoric disorder (premenstrual syndrome or L2D2) was tested. Twenty-two PMS patients were compared to twenty-two controls. Levels of beta-endorphin, ACTH, FSH, LH, cortisol, prolactin and TRH were measured on the first and twentieth days after menses. PMS subjects exhibited a significantly greater drop in the opiate, beta-endorphin, (p less than .001) than controls. No relationship or significant e was seen with the other hormones/transmitters tested. The symptoms of PMS may be due to noradrenergic rebound following beta-endorphin decline. Symptomatic and pharmacological morphine withdrawal and manic phase of bipolar disorder are discussed as possible models for L2D2.
Giannini
A J
AJ
Ohio State University.
Martin
D M
DM
Turner
C E
CE
D000328:Adult; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D011293:Premenstrual Syndrome / Q000097:blood* / Q000523:psychology; D012016:Reference Values; D001615:beta-Endorphin / Q000097:blood*
D001615:beta-Endorphin