Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine.
The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems.
Wozniak
K M
KM
LCS/NIAAA, NIH Clinical Center, Bethesda, MD 20892.
Pert
A
A
Linnoila
M
M
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013238:Stereotaxic Techniques; D000077526:Tropisetron
D007211:Indoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D000431:Ethanol; D000077526:Tropisetron; D004298:Dopamine