title: Chronokinetic study of netilmicin in man.
abstract: Netilmicin 1.5 mg/kg body weight was administered intravenously every 8 h for 2 days to 8 patients with normal renal function. Significant elevation of mean and trough plasma concentrations was found at 05.00 h and 09.00 h. This was considered to be due to circadian variation, with possible accumulation during the night. The clinical importance of this phenomenon in relation to the development of aminoglycoside toxicity awaits further investigation.
authors: Department of Infectious Diseases, Lyon, France.
authors: F
authors: F
authors: Lucht
authors: S
authors: S
authors: Tigaud
authors: G
authors: G
authors: Esposito
authors: J
authors: J
authors: Cougnard
authors: M P
authors: MP
authors: Fargier
authors: D
authors: D
authors: Peyramond
authors: J L
authors: JL
authors: Bertrand
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013223:Statistics as Topic
chemical_list: D009428:Netilmicin