Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer.
The isopenicillin N synthase genes from three fungal species, three Gram-positive species, and one Gram-negative bacterial species share an unusually high sequence similarity. A phylogenetic analysis was carried out to determine which type of evolutionary scenario best accounts for this similarity. The most plausible scenario is one in which a horizontal gene-transfer event, from the prokaryotes to the eukaryotes, occurred at a time close to the divergence between the Gram-positive and the Gram-negative bacteria.
Landan
G
G
Interdisciplinary Program for Fostering Excellence, Tel Aviv University, Ramat Aviv, Israel.
Cohen
G
G
Aharonowitz
Y
Y
Shuali
Y
Y
Graur
D
D
Shiffman
D
D
D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology / Q000235:genetics*; D005075:Biological Evolution; D005658:Fungi / Q000201:enzymology / Q000235:genetics*; D005798:Genes, Bacterial; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000235:genetics*; D014162:Transfection
D010088:Oxidoreductases; C038370:isopenicillin N synthetase