Stereoselective reactions. XVIII. Synthesis and cytotoxicity of the demethyl derivatives of steganes.
Demethyl derivatives of steganes and deoxypodorhizon, 3, 4, 6, 7, 9, 10, 12, 13, 18, 23, were prepared by the selective demethylation of the methoxy group of steganes and deoxypodorhizon, 2, 5, 8, 11, 22. The cytotoxicity of these derivatives was evaluated against KB cell and was found not to exceed that of the parent steganes. 4-Demethyldeoxypodorhizon (18) was found to show more potent cytotoxicity than deoxypodorhizon.
Tomioka
K
K
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Kawasaki
H
H
Koga
K
K
D015107:4-Butyrolactone / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007624:KB Cells; D011033:Podophyllin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D011033:Podophyllin; D015107:4-Butyrolactone