title: Relationship between carcinogenicity in rodents and the induction of sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells.
abstract: Two independent analyses were carried out to compare the induction of sister chromatid exchanges and of chromosomal aberrations as predictors of carcinogenicity. Using both a classical and a Bayesian approach, as well as by analysis of the structural fragments generated by CASE, an artificial intelligence system, it is included that individually neither of these tests is a satisfactory predictor of carcinogenicity. However, because the analysis revealed that each of the cytogenetic assays responds to a different set of structural features associated with carcinogenicity, it can be concluded that the assays can be included in a battery of tests to improve predictivity.
authors: Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
authors: H S
authors: HS
authors: Rosenkranz
authors: F K
authors: FK
authors: Ennever
authors: G
authors: G
authors: Klopman
mesh_terms: D000818:Animals; D001185:Artificial Intelligence; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000494:pharmacology / Q000633:toxicity*; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D002273:Carcinogens