Familial essential thrombocythemia.
We report three siblings (2 F, 1 M) aged 9, 12, and 15 years with a thrombocytosis, above 650 X 10(9)/l for at least 18 months and a leukocyte alkaline phosphatase score below 37. The diagnosis of essential thrombocythemia was based upon the exclusion of a reactive thrombocytosis or another myeloproliferative disease. Cytogenetic examination of marrow cells was normal.
Fernandez-Robles
E
E
Department of Haematology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Brussels, Belgium.
Vermylen
C
C
Martiat
P
P
Ninane
J
J
Cornu
G
G
D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000235:genetics; D010976:Platelet Count; D013920:Thrombocythemia, Essential / Q000097:blood* / Q000235:genetics* / Q000473:pathology