Comparison of the effects of intra-arterial and intravenous cisplatin on both limb tumor and lung metastases of transitional cell carcinoma RBT-1 in rats.
The effects of intra-arterial (i.a.) and intravenous (i.v.) cisplatin on both limb tumor and lung metastases of transitional cell carcinoma RBT-1 in rats were compared. Tumor weights of limb tumors and the amount of lung nodules were evaluated on the eighth day after chemotherapy experiments. Both cisplatin 5 mg/kg i.a. and 5 mg/kg i.v. were administered to rats, but the intra-arterial method showed a significantly better effect on the limb tumor, whereas the intravenous method tended to be more effective on the lung metastases. Using the same dosage (5 mg/kg), the intra-arterial cisplatin group demonstrated a weaker level of nephrotoxicity and a smaller loss of body weight than seen in the intravenous cisplatin group. When a higher dose of cisplatin (6 mg/kg) was administered in the intra-arterial group, the antitumor effect on lung metastases and nephrotoxicity were similar to those of the group given cisplatin 5 mg/kg i.v. These data suggest that the dose of intra-arterial cisplatin can be slightly higher than that of intravenous cisplatin. Subsequently, a similar antitumor effect on lung metastases and a significantly better antitumor effect on primary tumor may be obtained at the equitoxic level.
Iwamoto
Y
Y
Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sugioka
Y
Y
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006614:Hindlimb; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D009368:Neoplasm Transplantation; D010984:Platinum / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains
D010984:Platinum; D002945:Cisplatin