Mechanisms and clinical significance of resistance to new beta-lactam antibiotics.
The newer beta-lactam antibiotics, including various ureidopenicillins, second- and third-generation cephalosporins, carbapenems and monobactams, are active against many bacteria that are resistant to older penicillins, such as ampicillin and ticarcillin. Nonetheless, resistance to the newer agents can arise, and in this article the mechanisms whereby it does so are reviewed and their clinical significance is discussed.
Livermore
D M
DM
Department of Medical Microbiology, London Hospital Medical College.
Wood
M J
MJ
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000187:drug effects; D002876:Chromosomes, Bacterial; D003429:Cross Reactions; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000201:enzymology; D006602:Hexosyltransferases; D006801:Humans; D002267:Muramoylpentapeptide Carboxypeptidase / Q000187:drug effects; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D047090:beta-Lactams; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases