Heat production rate in blood lymphocytes as a prognostic factor in non-Hodgkin's lymphoma.
The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non-Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade lymphomas (p = 0.01). Median survival was 39 months for patients with normal values and 8.5 months for those with elevated values (p = 0.005). In a subgroup of 38 patients with high or intermediate grade NHL stage III-IV, 17 patients with abnormally high lymphocyte heat production rates had a significantly shorter survival than 21 patients with normal values (p = 0.01). In a multivariate analysis the prognostic impact of lymphocyte heat production was superior to histologic malignancy grade, clinical stage and age.
Monti
M
M
Department of Internal Medicine, University Hospital, Lund, Sweden.
Brandt
L
L
Ikomi-Kumm
J
J
Olsson
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002151:Calorimetry; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D013816:Thermodynamics