The effect of completely purine-free diet of low sodium content on purine intermediates and end-product.
Intake of completely purine-free foods of low sodium content increased the plasma concentrations of both hypoxanthine and inosine and the urinary excretion of hypoxanthine, while it decreased the urinary excretion of uric acid and the fractional clearance of uric acid. However, this diet affects neither nucleotides (inosine monophosphate, adenosine monophosphate, adenosine diphosphate and adenosine triphosphate) in red blood cells, enzymes (purine nucleoside phosphorylase, adenosine deaminase and hypoxanthine guanine phosphoribosyl transferase) in red blood cells nor the fractional clearance of oxypurines. These results suggest that the salvage of purines becomes more effective by limiting the conversion of hypoxanthine to xanthine and limiting the loss of uric acid during intake of completely purine-free foods of low sodium content; also that a decrease in the fractional clearance of uric acid due to completely purine-free foods of low sodium content may be an additional mechanism associated with the conservation of purines but is more likely to be a response to the low sodium diet on the renal handling of uric acid.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Yokoyama
H
H
Moriwaki
Y
Y
Takahashi
S
S
Suda
M
M
Hada
T
T
Higashino
K
K
D000328:Adult; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007042:Hypoxanthines / Q000097:blood / Q000652:urine; D007288:Inosine / Q000097:blood; D008297:Male; D009705:Nucleosides / Q000097:blood*; D009711:Nucleotides / Q000097:blood*; D011687:Purines / Q000008:administration & dosage*; D012982:Sodium, Dietary / Q000008:administration & dosage*; D014527:Uric Acid / Q000652:urine
D007042:Hypoxanthines; D009705:Nucleosides; D009711:Nucleotides; D011687:Purines; D012982:Sodium, Dietary; D014527:Uric Acid; D007288:Inosine