Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis.
We report 2 patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni enteritis. Electrophysiologic studies indicated that the predominant process was axonal degeneration of motor nerves, and clinical recovery was poor. Serum testing by thin-layer chromatography and enzyme-linked immunosorbent assay revealed that the sera from both patients contained high titers of IgG antibody against GM1 ganglioside. These cases may represent a subgroup of GBS as acute axonal polyneuropathy following C jejuni enteritis associated with anti-GM1 antibodies.
Yuki
N
N
Department of Neurology, Niigata University, Japan.
Yoshino
H
H
Sato
S
S
Miyatake
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D002169:Campylobacter Infections / Q000150:complications*; D016123:Campylobacter jejuni; D004751:Enteritis / Q000150:complications*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D011129:Polyradiculoneuropathy / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D013497:Sural Nerve / Q000503:physiopathology; D013979:Tibial Nerve / Q000503:physiopathology; D014459:Ulnar Nerve / Q000503:physiopathology
D001323:Autoantibodies; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside