62Cu-labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate for regional plasma volume measurement: application of new 62Zn/62Cu generator system.
62Cu-Labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate was performed using a newly developed 62Zn/62Cu generator system. HSA-DTS was easily labeled with 62Cu, by simple mixing with 62Cu-generator eluate. In vivo blood clearance of 62Cu-HSA-DTS was similar to 131I-HSA, indicating the high applicability of 62Cu-HSA-DTS as a method for plasma volume measurement. In a positron emission tomography study of a dog, a clear plasma pool image of the head region was obtained.
Fujibayashi
Y
Y
Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
Matsumoto
K
K
Arano
Y
Y
Yonekura
Y
Y
Konishi
J
J
Yokoyama
A
A
D000818:Animals; D001811:Blood Volume Determination / Q000379:methods*; D003301:Copper Radioisotopes; D004285:Dogs; D006801:Humans; D008297:Male; D011817:Rabbits; D012709:Serum Albumin / Q000032:analysis*; D013882:Thiosemicarbazones / Q000097:blood*; D014055:Tomography, Emission-Computed; D015037:Zinc Radioisotopes
D003301:Copper Radioisotopes; D012709:Serum Albumin; D013882:Thiosemicarbazones; D015037:Zinc Radioisotopes