title: Polarographic study of nifurtimox.
abstract: Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4e process and subsequently the amine being formed in a 2e process at a pH value below 4. The C = N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond. The differential pulse polarographic peaks for the reduction of the nitro group to the hydroxylamine group at pH 6 were used in developing a new polarographic method for the determination of nifurtimox in pharmaceutical forms.
authors: Electrochemistry Laboratory, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
authors: J A
authors: JA
authors: Squella
authors: W
authors: W
authors: Muñoz
authors: C
authors: C
authors: Paulos
authors: L J
authors: LJ
authors: Nuñez-Vergara
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D009547:Nifurtimox / Q000737:chemistry*; D011048:Polarography; D013607:Tablets
chemical_list: D013607:Tablets; D009547:Nifurtimox