Dose dependent enzyme induction by oxcarbazepine?
Antipyrine half life and clearance was compared in four patients with classical idiopathic trigeminal neuralgia during carbamazepine (CBZ) or CBZ/phenytoin (PHT) and after substitution with oxcarbazepine (OXC) monotherapy. OXC is observed to be less of a hepatic enzyme inducer than CBZ or CBZ/PHT in combination, however induction by OXC may be dose related.
Patsalos
P N
PN
Institute of Neurology, National Hospital for Nervous Diseases, London, UK.
Zakrzewska
J M
JM
Elyas
A A
AA
D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D000983:Antipyrine / Q000493:pharmacokinetics; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D010672:Phenytoin / Q000493:pharmacokinetics; D014277:Trigeminal Neuralgia / Q000188:drug therapy / Q000378:metabolism
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D000983:Antipyrine; D000078330:Oxcarbazepine