Effects of food intake and meal size on the bioavailability of sulpiride in two dosage forms.
This study examined the influences of food intake on sulpiride (100 mg) bioavailability from a commercial film-coated tablet and of the meal size (small, medium or large) on sulpiride bioavailability from an aqueous solution in three healthy male volunteers. The cumulative urinary excretions of sulpiride for 48 h (Du48) from two dosage forms following oral administration were decreased approximately 30% by food intake. Also, a good correlation was found between the bioavailability of sulpiride from the solution and size of meals with the same dietary components. These results suggest that food intake and meal size before dosing significantly affect the gastrointestinal absorption of sulpiride.
Shinkuma
D
D
Department of Pharmacy, Hyogo College of Medicine, Japan.
Hamaguchi
T
T
Kobayashi
M
M
Yamanaka
Y
Y
Mizuno
N
N
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013469:Sulpiride / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013469:Sulpiride