Angiotensin-converting enzyme inhibitors in pregnancy may result in neonatal renal failure.
Oligohydramnios and neonatal renal failure is reported in a premature infant whose mother had used enalapril in weeks 32-35 of her pregnancy. The infant recovered adequate renal function after peritoneal dialysis. Review of the literature supports our view that angiotensin-converting enzyme inhibitors should not be used in pregnancy; if they are, both mother and fetus should be monitored with extreme care.
Hulton
S A
SA
Department of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg Hospital.
Thomson
P D
PD
Cooper
P A
PA
Rothberg
A D
AD
D058186:Acute Kidney Injury / Q000139:chemically induced*; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*
D004656:Enalapril