Is systemic treatment of osteoporosis and mandibular resorption possible?
It is argued that mandibular resorption can be considered as osteoporotic in nature. This calls for a systemic approach in its treatment. One aspect mostly neglected is the tendency of bone to bind calcium and phosphate ions. A direct measure for this tendency is the difference in pH between the bone extracellular fluid and blood plasma with octocalcium phosphate. Calculation of these degrees of saturation of about 2000 data of blood plasma compositions given in the literature learned that calcitonin injections, estrogen replacement and magnesium supplementation increase the tendency of bone to bind calcium and phosphate ions and, hence, should be used in the therapy of mandibular resorption and of bone resorption in general.
Driessens
F C
FC
Department of Oral Biomaterials, Catbolic University, Nijmegen, The Netherlands.
Verbeeck
R M
RM
Van Dijk
J W
JW
D001862:Bone Resorption / Q000188:drug therapy* / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy*; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism
D002116:Calcitonin; D008274:Magnesium; D002118:Calcium