[Effects of purine-rich nutrition on the renal and extrarenal excretion of purine catabolites in Dalmatian dogs].
In eight Dalmatian dogs exogenous effects (dietary purine, xylit infusion) on plasma uric acid were examined and relationships between purine intake and excretion were established. Increasing purine intake resulted in a linear increase in renal excretion of urate (r = 0.952) and a less steep increase of allantoin (r = 0.901). In pairs of two animals with low and high purine intakes the metabolic fluxes in steady state were measured by continuous infusion of (2-14C) urate. The extrarenal excretion rates of urate + allantoin during high-purine and low purine feeding averaged 2.9% and 8.5% of entry rates. The results are discussed in comparison with human data and a remarkably good agreement is observed.
Giesecke
D
D
Institut für Physiologie, Physiologische Chemie und Ernährungsphysiologie, Universität München.
Stangassinger
M
M
D000481:Allantoin / Q000652:urine; D000818:Animals; D004032:Diet; D004285:Dogs / Q000378:metabolism* / Q000652:urine; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D011687:Purines / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D014527:Uric Acid / Q000097:blood
D011687:Purines; D014527:Uric Acid; D000481:Allantoin
Einflüsse purinreicher Ernährung auf die renale und extrarenale Exkretion von Purinkataboliten bei Dalmatiner-Hunden.