Pachyonychia congenita: a four generation pedigree.
Pachyonychia congenita is a rare genodermatosis characterized by symmetrical thickening and discoloration of the nails with a wedge-shaped, pinched-up, or claw-like appearance. Subungual hyperkeratosis results in a lifting up of the free edge of the nail. Nail changes may be seen alone or in combination with a variety of other cutaneous findings. The authors present a kindred with fifteen cases of pachyonychia congenita in four generations, in Lebanon County, Pennsylvania.
Fitzgerald
B J
BJ
Department of Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042.
Sanders
L J
LJ
D000328:Adult; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000151:congenital / Q000235:genetics*; D010375:Pedigree