Amelioration by menadione of the experimental chronic immune arthritis in the rabbit.
The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose 6-phosphate dehydrogenase in the synovial lining cells since the fourfold elevation of this activity was shown to be fundamental in the human condition. An equal elevation of this activity has now been demonstrated in the rabbit model. Furthermore, it has been shown that the oral administration of menadione decreases this activity towards normality with a concomitant decrease in the degree of inflammation.
Pitsillides
A A
AA
Division of Cellular Biology, Kennedy Institute of Rheumatology, London, U.K.
Blake
S M
SM
Glynn
L E
LE
Bitensky
L
L
Chayen
J
J
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D011817:Rabbits; D013583:Synovial Membrane / Q000201:enzymology; D014812:Vitamin K / Q000627:therapeutic use*
D014812:Vitamin K; D005954:Glucosephosphate Dehydrogenase