title: Egg albumin microspheres containing paracetamol for oral administration. II. In vivo investigation.
abstract: Egg albumin microspheres containing paracetamol for oral administration were prepared and their in vivo characteristics evaluated. The egg albumin microspheres were able to improve the organoleptic characteristics of paracetamol formulations. The pharmacokinetic characteristics of three different formulations of paracetamol were evaluated in six volunteers. The formulations administered orally were: (1) Paracetamol granulated with lactose (reference), (2) Egg albumin microspheres and (3) Egg albumin microspheres coated with polymethacrylate. The pharmacokinetic characteristics for formulations 1 and 2 were similar but formulation 3 gave significant differences (p less than 0.05) in Ka, Cmax and tmax. No significant differences in relative bioavailability were observed.
authors: Departamento de Farmacia y Technologia Farmaceutica, Facultad de Farmacia, Universidad Complutense, Ciudad Universitaria, Madrid, Spain.
authors: J J
authors: JJ
authors: Torrado
authors: L
authors: L
authors: Illum
authors: R
authors: R
authors: Cadorniga
authors: S S
authors: SS
authors: Davis
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D006801:Humans; D007700:Kinetics; D007785:Lactose; D010047:Ovalbumin; D011109:Polymethacrylic Acids
chemical_list: D002214:Capsules; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D000082:Acetaminophen; D010047:Ovalbumin; D007785:Lactose