[Effect of carbohydrate-enriched diet and subsequent food restriction on life prolongation in Fischer 344 male rats].
Increased proportion of carbohydrates (dextrin) in the diet has a life prolonging effect upon male Fischer 344 rats; however, the effect of this diet appears only when the rats aged from 6 weeks to 6 months are on diet, after this treatment median survival of experimental animals increases by 96 days and the 10th percentile increases on the average by 10 days (n-60). Further maintenance of animals on the same diet has minimum effect: animals being on this diet throughout the whole life exhibit a median lifespan increase by 120 days and an increase in the 10th percentile by 41 days. However, if such animals aged 6 months are transferred to a restricted (60%) food intake regimen (control diet, not enriched with carbohydrate) a further increase in median and 10th percentile lifespan prolongation can be observed reaching 328 and 396 days, respectively as compared to controls. The effects of this early feeding (from 6 weeks to 6 months) with a carbohydrate-enriched diet available ad libitum and food restricted (60% controls) regimen fed from the age of 6 months onwards are additive, the final results being identical as if the animals are kept on the 60% food restricted intake throughout the whole life.
Khorakova
M
M
Institute of Physiology, Czechoslovakian Academy of Sciences, Prague.
Deĭl
Z
Z
Khausman Dzh
Matsek
K
K
D000818:Animals; D003912:Dextrins / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005508:Food Deprivation / Q000502:physiology*; D008017:Life Expectancy; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D003912:Dextrins; D004040:Dietary Carbohydrates
Vliianie diety, obogashchennoĭ uglevodami, i posleduiushchego ogranicheniia kolichestva potrebliaemoĭ pishchi na uvelichenie prodolzhitel'nosti zhizni samtsov krys linii Fisher 344.