[Effect of indomethacin on the vital prognosis and homeostasis of rats with kidney insufficiency].
The medicamentous-therapeutic modulation of pathogenic hyperfiltration of residual nephrons by the prostaglandin synthesis inhibitor indomethacin was evaluated again. The experimental study of inbred wistar rats including a low indomethacin dosage of 1.5 mg/kg BW, a strong reduction of renal parenchyma (80%) and an increased food protein content of 40% did show the known results: indomethacin may impair the vital prognosis of severe renal injury.
Hortian
B
B
Klinik für Innere Medizin, Universität Rostock.
Wüstenberg
P W
PW
Wenk
R
R
D000818:Animals; D005260:Female; D007213:Indomethacin / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects*; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains
D007213:Indomethacin
Indometacineffekt auf Vitalprognose und Homöostaselage niereninsuffizienter Ratten.