[The urinary excretion of renal prostanoids in children with chronic obstructive pyelonephritis in vesicoureteral reflux before and after antireflux operations].
The excretion of renal prostaglandins (PGE, PGF2 alpha, 6-keto-PGE1 alpha and TKB2) was studied in 45 children with chronic obstructive pyelonephritis in the presence of vesicoureteral reflux with account for the disease stage (partial remission--group I; total clinical and laboratory remission--group II) in various periods of surgical corrections of the impaired urodynamics in the area of vesicoureteral segments (in the early postoperative period of 12-14 days after the surgery; in the follow-up period of 6-12 months after the surgery). Preoperative observation of Group I children revealed a significant decrease in urinary PGF2 alpha excretion in the presence of an increase in the circadian TKB2 and 6-keto-PGF1 alpha excretion, whereas the patients from Group II who had normal levels of TKB2 and 6-keto-PGF1 alpha excretion, the levels of PGE and PGF2 alpha were lowered. The retention of sodium was documented in both groups. There was a total recovery of renal sodium and water excretion 6-12 months after the surgery. Children without the urinary syndrome (group II) demonstrated normalization of all secreted prostanoids, whereas in those with pronounced severity of pyelonephritis (group I), the excretion of sodium and diuresis were likely to be provided by hyperproduction of vasodilating sodium and diuretic PGE.
Kucherenko
A G
AG
Iatsyk
P K
PK
Markov
Kh M
KhM
Isakov
A
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D011184:Postoperative Period; D011453:Prostaglandins / Q000652:urine*; D011704:Pyelonephritis / Q000209:etiology / Q000601:surgery / Q000652:urine*; D012074:Remission Induction; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000601:surgery / Q000652:urine*
D011453:Prostaglandins
Ekskretsiia pochechnykh prostanoidov s mochoĭ u deteĭ s khronicheskim obstruktivnym pielonefritom pri puzyrno-mochetochnikovom refliukse do i posle antirefliuksnykh operatsiĭ.