Sickle haemoglobin, G-6PD deficiency and malaria in western Orissa.
Sixty cases of malaria were screened for sickle haemoglobin and G-6PD deficiency. Plasmodium vivax was detected in 40 (66%) and Plasmodium falciparum in 21 (35%) cases, with six of the latter having cerebral manifestation. Sickle Hb was found in 7 (11.5%) patients and G-6PD deficiency in 3 (5%) cases. Both patients with SS disease had vivax malaria, while of 5 with sickle cell trait 3 had only vivax, one only falciparum and one mixed infection. Amongst G-6PD deficient patients one had vivax and two falciparum malaria. One of the latter had both SC trait and G-6PD deficiency. Thus, adult persons with SS disease or SC trait were not found to be resistant to either vivax or falciparum malaria. A high frequency (5%) of G-6PD deficiency amongst malaria patients warrants a caution against indiscriminate use of 8-aminoquinoline drugs.
Kar
B C
BC
VSS Medical College, Sambalpur, Orissa.
Agrawal
K C
KC
Panda
A
A
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D005953:Glycogen Storage Disease Type I / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008288:Malaria / Q000150:complications* / Q000453:epidemiology / Q000469:parasitology; D010963:Plasmodium falciparum / Q000302:isolation & purification; D010966:Plasmodium vivax / Q000302:isolation & purification; D012805:Sickle Cell Trait / Q000150:complications* / Q000453:epidemiology