Oocyte donation: the role of endometrial receptivity.
Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants delivered and one early pregnancy loss). All patients had endometrial biopsies taken in a preceding cycle of hormone replacement therapy. The majority (61%) showed delayed maturation compared with the expected appearances for the day of the cycle as assessed on light microscopy. Patients who conceived had a significantly better endometrial response than those who did not. Five out of seven patients (71%) conceived when the endometrium was 'in phase' (less than 2 days' delay). This suggests that endometrial receptivity is a key factor in conception. The implications for improving outcome from in-vitro fertilization treatment are discussed.
Davies
M C
MC
Department of Reproductive Endocrinology, Cobbold Laboratories, University College and Middlesex School of Medicine, London, UK.
Anderson
M C
MC
Mason
B A
BA
Jacobs
H S
HS
D000328:Adult; D015925:Cryopreservation; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use; D014019:Tissue Donors; D014021:Tissue Preservation
D011374:Progesterone