[Changes in the contents of epidermal growth factor and EGF-like polypeptides in the liver tissue of rats in N-nitrosodiethylamine-induced hepatocarcinogenesis].
It has been determined that concentration of EGF-like substances in the liver of rats with N-diethylnitrosamine-induced hepatocarcinogenesis increases and reaches its maximum in tumours (50-150 ng/mg protein). In the regenerating liver the amount of these peptides does not exceed 10 ng/mg protein. High pressure gel-filtration of appropriate extracts has revealed EGF-competing substances with m. w. about 20-30 kD in the liver carcinomas. The presented data confirm that registered EGF-like substances belong to TGF-alpha peptides.
Ivashchenko
Iu D
IuD
Garmanchuk
L V
LV
Fil'chenkov
A A
AA
Kulik
G A
GA
Kononenko
L I
LI
Bykorez
A I
AI
D000818:Animals; D002850:Chromatography, Gel; D004052:Diethylnitrosamine; D004815:Epidermal Growth Factor / Q000032:analysis*; D008099:Liver / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008115:Liver Regeneration; D051379:Mice; D051381:Rats; D016211:Transforming Growth Factor alpha / Q000032:analysis*; D014407:Tumor Cells, Cultured
D016211:Transforming Growth Factor alpha; D004052:Diethylnitrosamine; D004815:Epidermal Growth Factor
Izmenenie soderzhaniia épidermal'nogo faktora rosta i podobnykh emu polipeptidov v tkani pecheni krys pri gepatokantserogeneze, indutsirovannom N-nitrozodiétilaminom.