title: Absorption of 308-nm excimer laser radiation by balanced salt solution, sodium hyaluronate, and human cadaver eyes.
abstract: Absorption of the excimer laser radiations of 193-nm argon fluorine and 308-nm xenon chloride in balanced salt solution, sodium hyaluronate, and human cadaver eyes was measured. The absorption of these materials as considerably different for the two wavelengths; we found that 308-nm light experienced much less absorption than the 193-nm light. The extinction coefficient (k) for 308 nm was k = 0.19/cm for balanced salt solution and k = 0.22/cm for sodium hyaluronate. In contrast to this, the extinction coefficient for 193 nm was k = 140/cm for balanced salt solution and k = 540/cm for sodium hyaluronate. Two 1-day-old human phakic cadaver eyes showed complete absorption with both wavelengths. Using aphakic eyes, incomplete absorption was noted at the posterior pole with 308 nm and complete absorption was noted with 193 nm. The extinction in the anterior part of aphakic eyes (the first 6 mm) was 4.2/cm for 308 nm, meaning that the intensity of the light is reduced by a factor of 10 after traveling the first 5.5 mm. However, we observed that the material in the eye fluoresces, meaning the 308 nm is transformed into other (longer) wavelengths that travel through the total eye with minimal absorption. Conclusions drawn from this experiment are that the use of the 308-nm wavelength may have undesirable side effects, while the use of the 193-nm wavelength should be consistent with ophthalmic use on both the cornea and the lens.
authors: Department of Ophthalmology, University of California, Irvine 92717.
authors: R H
authors: RH
authors: Keates
authors: R T
authors: RT
authors: Bloom
authors: R T
authors: RT
authors: Schneider
authors: Q
authors: Q
authors: Ren
authors: J
authors: J
authors: Sohl
authors: J J
authors: JJ
authors: Viscardi
mesh_terms: D000042:Absorption; D000085:Acetates / Q000528:radiation effects*; D004338:Drug Combinations; D005123:Eye / Q000528:radiation effects*; D006801:Humans; D006820:Hyaluronic Acid / Q000528:radiation effects*; D007231:Infant, Newborn; D007834:Lasers; D008903:Minerals / Q000528:radiation effects*; D012542:Scattering, Radiation; D012965:Sodium Chloride
chemical_list: D000085:Acetates; C030660:BSS solution; D004338:Drug Combinations; D008903:Minerals; D012965:Sodium Chloride; D006820:Hyaluronic Acid