title: Gut-associated immune effector responses in immunocompetent and immunocompromised mice with Giardia lamblia.
abstract: Significantly higher Giardia lamblia trophozoites load in the intestine of infected mice accompanied pronounced influx of suppressor/cytotoxic T cells (Lyt 2.2+), T cells (Thy 1.2+) and significant reduction in IgA-containing cells in the gut during the establishment and peak phases of infection. The induction of helper/inducer T cells (Lyt 1.1+) and significant enhancement of IgA-containing cells in gut resulted in the decline of the trophozoite loads. However, the prior treatment of animals with dexamethasone alone resulted in significant reduction in helper/inducer T cells (Lyt 1.1+) and the IgA-containing cells in the gut; the percents of suppressor/cytotoxic T cells (Lyt 2.2+) and IgM-containing cells remained unaltered. Although the G. lamblia infection in such animals further significantly increased the influx of suppressor/cytotoxic T cells, the late response of helper/inducer T cells and IgA-containing cells was abrogated during the decline phase of infection. The significant reduction in the trophozoite load - despite immuno-suppressive therapy - appeared to be due to unaltered IgM response in such animals which probably took over the function of IgA in defense against G. lamblia. The data of the investigation thus suggested a role of helper/inducer T cells and antibodies producing cells in gut as important effector cells resulting in the termination of primary G. lamblia infection.
authors: Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: R
authors: R
authors: Khanna
authors: K
authors: K
authors: Kum
authors: V K
authors: VK
authors: Vinayak
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000378:metabolism; D000921:Antibody-Producing Cells / Q000276:immunology; D005260:Female; D005873:Giardiasis / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D007121:Immunocompetence; D007421:Intestine, Small / Q000276:immunology* / Q000469:parasitology / Q000473:pathology; D007583:Jejunum / Q000469:parasitology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan