[The pro-fibrotic and pro-oxidant action of isoniazid].
As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue. Two mechanisms of isoniazid's pro-fibrotic action are presented.
Andrzheiuk
N I
NI
Smirnova
N A
NA
Narovlianskaia
S E
SE
Novoselova
V P
VP
Kruglova
E G
EG
D000818:Animals; D007538:Isoniazid / Q000627:therapeutic use* / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D007538:Isoniazid
Profibroticheskoe i prooksidantnoe deĭstvie izoniazida.