[Malignant primary non-Hodgkin's lymphoma of the central nervous system. Anatomo-clinical analysis of 35 cases].
We have recorded 35 primary central nervous system (C.N.S.) lymphomas from 1982 to 1988 in Bordeaux in order to show their increasing frequency, and clinicopathological features. Mean age was 57 (15-81). Only one patient was immunocompromised. Clinical symptoms consisted mostly of focal neurologic deficits (23 cases) and mental disturbance (16 cases). Diagnosis was made on bioptic material (20 cases mostly stereotaxic), surgery (13 cases) or autopsy (2 cases). Lymphoma was localised in the brain with unifocal (50%), multifocal (30%) or diffuse (20%) involvement at computed tomographic scans. Histopathological features were diffuse infiltration of the cerebral tissue with perivascular clustering. Two particular cases were observed: one with mostly a perivascular pattern affecting the white matter of both cerebral hemisphere; another with amyloidosis deposits. According to Working Formulation, histologic types were of intermediate or high grade of malignancy (66%), with 35% large, non cleaved-cell (centroblastic) subtype. Immunochemistry on paraffin sections with UCHL-1, MB-2, LN-1, L-26 showed that 94% were of B-cell nature and only one probably of T-cell origin.
Vergier
B
B
Service d'Anatomopathologie, Hôpital Pellegrin, Bordeaux.
Rivel
J
J
de Mascarel
A
A
Vital
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
Lymphomes malins non hodgkiniens primitifs du système nerveux central. Analyse anatomo-clinique de 35 cas.