Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis.
L-Methionine and DL-ethionine decreased production of thiolutin and aureothricin in Streptomyces kasugaensis. In the presence of L-methionine the culture also produced 3-methylthioacrylic acid, 3-methylthiopropionic acid and 3,6-bis-(2-methylthioethyl)-2,5-dioxopiperazine. Production of the metabolites depended on the concentration of L-methionine in the medium.
Sturdíková
M
M
Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Czechoslovakia.
Proksa
B
B
Uhrín
D
D
Fuska
J
J
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D003545:Cysteine / Q000378:metabolism; D005001:Ethionine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*; D013438:Sulfhydryl Compounds
D000900:Anti-Bacterial Agents; D003470:Culture Media; D011758:Pyrroles; D011760:Pyrrolidinones; D013438:Sulfhydryl Compounds; C006361:acetopyrrothine; C010684:aureothricin; D008715:Methionine; D003545:Cysteine; D005001:Ethionine