title: Proinsulin autoantibodies: association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type.
abstract: Antibodies reacting with proinsulin but not with insulin determinants have been observed recently in Type I diabetes. We describe here that ELISA-determined proinsulin autoantibodies (IgG-PAA) also occur in first-degree relatives of IDDM patients (38/513, 7.4% vs 1.9% in controls, P less than 0.025). In contrast to insulin autoantibodies (IgG-IAA) and islet cell antibodies (ICA) no association with HLA type was found. Furthermore, IgG-PAA occur independently of IgG-IAA and ICA. We conclude that the humoral autoimmune response to proinsulin determinants is under separate genetic control.
authors: Diabetes Research Institute, University of Düsseldorf, FRG.
authors: B
authors: B
authors: Kuglin
authors: B
authors: B
authors: Halder
authors: J
authors: J
authors: Bertrams
authors: D
authors: D
authors: Grüneklee
authors: F A
authors: FA
authors: Gries
authors: H
authors: H
authors: Kolb
mesh_terms: D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007328:Insulin / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D010375:Pedigree; D015995:Prevalence; D011384:Proinsulin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D006684:HLA-DR Antigens; D007070:Immunoglobulin A; D007328:Insulin; D011384:Proinsulin