Contraception with a vaginal ring releasing 3-keto desogestrel and ethinylestradiol.
Eleven healthy women used a contraceptive vaginal ring for three cycles. The rings released 15 micrograms of ethinylestradiol and 150 micrograms of 3-keto desogestrel per 24 hours. The rings were used for 21 days and then removed, rinsed in clean water and stored. After a 7-day ring-free period, the rings were reinserted. Totally, each ring was used for 3 cycles. The rings were well tolerated. The bleeding pattern was excellent. No woman showed any signs of ovulation when using the ring. Estradiol levels were suppressed, but showed an increase during the ring-free period as can be found during the pill-free period of an oral contraceptive regimen. When the ring was reinserted, the estradiol levels were rapidly suppressed again. SHBG capacity increased during use of the ring.
Olsson
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SE
Department of Obstetrics and Gynecology, University of Uppsala, Sweden.
Odlind
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D000328:Adult; D003274:Contraceptive Devices, Female; D017135:Desogestrel; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D009652:Norpregnenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D045167:Progesterone Congeners / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D009652:Norpregnenes; D045167:Progesterone Congeners; D012738:Sex Hormone-Binding Globulin; C044815:etonogestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D017135:Desogestrel