Antibiotic SB22484: a novel complex of the aurodox group. I. Taxonomy of the producing organism, isolation of the antibiotics and chemical and biological characterization.
Antibiotic SB22484 is a novel member of the aurodox type antibiotic group produced in submerged-fermentation cultures of Streptomyces sp. NRRL 15496. The antibiotic complex is composed of two pairs of isomers with MW's of 752 and 766. The individual isomers, which were separated by preparative HPLC, equilibrate to a mixture of the isomer pair when left in aqueous solution. In vitro, SB22484 antibiotics strongly inhibited neisseriae and were also active against Streptococci, Ureaplasma urealyticum and Haemophilus influenzae.
Selva
E
E
Merrell Dow Research Institute, Lepetit Research Center, Gerenzano (Varese), Italy.
Beretta
G
G
Pallanza
R
R
Goldstein
B P
BP
Berti
M
M
Edwards
D M
DM
Denaro
M
M
D000818:Animals; D000899:Aurodox / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006193:Haemophilus influenzae / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009343:Neisseria / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy; D012988:Soil Microbiology; D013291:Streptococcus / Q000187:drug effects; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism; D014509:Ureaplasma / Q000187:drug effects
D000899:Aurodox; C066792:SB 22484