[Interactions of radiation and biological response modifiers (BRMs) in the treatment of malignant tumor].
This article reports on attempt to characterize the interactions of radiation and BRMs in the treatment of malignant tumor on the basis of our some experimental results. BRMs have a high possibility to enhance radiation effects on tumor cells with in a radiation field and bring some benefits to host tumor immune system with minimizing deleterious effects of irradiation to the immune responses. But it is very difficult to determine the rational design of administration of BRMs to induce the most effective interactions on relevant immune system and other host responses in the combination with radiotherapy. We should make it clear how radiation can be useful to potentiate the tumor antigenecity or antitumor immune responses.
Mitsuhashi
N
N
Dept. of Radiology, Gunma Univ. School of Med.
Takahashi
M
M
Okazaki
A
A
Niibe
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002455:Cell Division; D003131:Combined Modality Therapy; D007155:Immunologic Factors / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D011509:Proteoglycans / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D007376:Interleukin-2; D011509:Proteoglycans; C010770:polysaccharide-K