title: Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats.
abstract: Sprague-Dawley rats were maintained on a daily regimen of nicotine, morphine or saline administration for 28 days. Following the discontinuation of the daily drug regimen, rats were given a choice of tap water or a saccharin-water solution. The rats previously receiving morphine drank significantly less saccharin-water solution than did the rats receiving nicotine or saline injections. The failure of the nicotine rats to display a conditioned aversion to the novel saccharin flavor suggests that nicotine did not produce a physiological withdrawal syndrome analogous to morphine withdrawal in this paradigm.
authors: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298.
authors: H F
authors: HF
authors: Villanueva
authors: S
authors: S
authors: Arezo
authors: J R
authors: JR
authors: James
authors: J A
authors: JA
authors: Rosecrans
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin; D013375:Substance Withdrawal Syndrome / Q000523:psychology*; D013649:Taste / Q000187:drug effects; D013997:Time Factors
chemical_list: D009538:Nicotine; D012439:Saccharin