Effects of a Japanese medicinal plant on the rat subtotal nephrectomy model: evaluation of its effect by microvascular casts.
Effects of a Japanese medicinal plant named Sairei-To, were examined in a rat experimental renal disease. Thirteen weeks after subtotal nephrectomy, the blood pressures in rats given Sairei-To (Sairei-To rats) were lower than those without Sairei-To. The urinary protein excretions and glomerular sclerosis were markedly decreased in the Sairei-To treated rats. Arteriolar diameters were measured using microvascular casts. The afferent and efferent arterioles were both significantly dilatated. The efferent arterioles in Sairei-To rats were dilated to a greater extent than that of the afferent. These results indicated that Sairei-To lessened renal damages in the rat subtotal nephrectomy model, possibly through the blood pressure reduction and the efferent arteriolar dilatation.
Kimura
K
K
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Ogawa
S
S
Tojo
A
A
Nanba
S
S
Matsuoka
H
H
Sugimoto
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007564:Japan; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria / Q000209:etiology / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal