Defective CSA-dependent granulopoiesis in patients with chronic drug-induced neutropenia.
Colony stimulating activity (CSA) and granulocyte-macrophage progenitor cells (GM-CFC) were assayed in the bone marrow and peripheral blood of 17 patients with drug-induced chronic neutropenia. Leukocyte-derived and monocyte/macrophage-derived CSA from the neutropenic patients was found to be significantly decreased compared to normal control. However, bone marrow and peripheral blood GM-CFC were within normal limits. These data suggest that in neutropenic patients monocyte/macrophages exhibit most likely a qualitative defect in CSA production, which may account at least in part, for the impaired granulopoiesis observed in drug-induced neutropenia.
Eliopoulos
G
G
Dept. of Medicine, University of Crete, School of Medicine, Greece.
Meletis
J
J
Fessas
P
P
Anagnou
N P
NP
D000293:Adolescent; D000328:Adult; D000368:Aged; D003114:Colony-Forming Units Assay; D003470:Culture Media; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology; D009503:Neutropenia / Q000097:blood* / Q000139:chemically induced
D003470:Culture Media