Competing risk analysis of life table data: application to lifetime risk computation.
In this pedagogic note we propose to assess the safety of treatment in a clinical trial, or the effect of risk exposure in a chronic animal study, in terms of two lifetime risks. These risks are computable from life table type data and take into account the effects of competing risks. We first describe their computational procedures in detail to demonstrate the need for their implementation in a computer program. We then illustrate their practical application through use of the data obtained from an actual clinical study.
Dong
M H
MH
Division of Biometrics, U.S. Food and Drug Administration, Rockville, MD 20857.
Dubey
S D
SD
O'Neill
R T
RT
Tsong
Y
Y
D006305:Health Status Indicators; D006801:Humans; D015993:Life Tables; D008838:Microcomputers / Q000706:statistics & numerical data; D010043:Outcome and Process Assessment, Health Care / Q000379:methods*; D010352:Patient Dropouts / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D015983:Selection Bias; D012984:Software; D016019:Survival Analysis