title: Alterations of hepatocellular peroxisomes in viral hepatitis in the mouse.
abstract: In addition to being found in peroxisomal diseases, peroxisomal alterations are also seen in viral hepatitis, though quantitative data are lacking. Experiments were performed on BALB/c mice. These mice were infected with Mouse Hepatitis Virus type 3 or were starved. The peroxisomes were cytochemically stained for catalase. Light microscopic, ultrastructural and morphometric analysis were performed. Several peroxisomal changes were observed 24 h after infection, and these changes became more pronounced after 40 h. There was a decrease in catalase activity, which was more pronounced in some regions, in some cells and in individual organelles; and there was also the onset of a progressive decrease in the number of organelles. It is believed that peroxisomes disappear by lysis. Proliferation probably occurs simultaneously up to 40 h after infection. At 48 h, necrotic foci are found to have swollen peroxisomes, and thus destruction is enhanced. Although peroxisomes seem to be sensitive markers of hepatic injury, they show a heterogeneous reaction pattern. Our results are discussed in relation to human viral hepatitis.
authors: Department of Human Anatomy, Vrije Universiteit Brussel, Belgium.
authors: D
authors: D
authors: De Craemer
authors: A
authors: A
authors: Bingen
authors: M
authors: M
authors: Langendries
authors: J P
authors: JP
authors: Martin
authors: F
authors: F
authors: Roels
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D006524:Hepatitis, Viral, Animal / Q000201:enzymology / Q000473:pathology*; D008099:Liver / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008830:Microbodies / Q000201:enzymology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D015388:Organelles / Q000201:enzymology / Q000648:ultrastructure
chemical_list: D002374:Catalase