Validation of a method for determination of tetracycline antibiotics in salmon muscle tissue.
A method was validated for analysis of oxytetracycline (OTC), tetracycline (TC), and chlortetracycline (CTC) in fortified salmon muscle tissue. Recoveries of OTC were 100 +/- 6, 86 +/- 6, and 82 +/- 5% (n = 6) at fortification levels of 1.0, 0.5, and 0.2 ppm, respectively. Recoveries of TC were 68 +/- 4, 65 +/- 6, and 66 +/- 7%; recoveries of CTC were 45 +/- 9, 48 +/- 8, and 0%, respectively. Detection limits for OTC and TC were 0.08 and 0.09 ppm, respectively.
Reimer
G J
GJ
CanTest Ltd., Vancouver, British Columbia, Canada.
Young
L M
LM
D000818:Animals; D002751:Chlortetracycline / Q000032:analysis; D002853:Chromatography, Liquid; D004350:Drug Residues / Q000032:analysis*; D005374:Filtration; D007202:Indicators and Reagents; D009132:Muscles / Q000737:chemistry*; D010118:Oxytetracycline / Q000032:analysis; D012474:Salmon / Q000378:metabolism*; D013752:Tetracycline / Q000032:analysis; D013754:Tetracyclines / Q000032:analysis*
D007202:Indicators and Reagents; D013754:Tetracyclines; D013752:Tetracycline; D002751:Chlortetracycline; D010118:Oxytetracycline