[The research of filaricides for the control of african onchocerciasis].
Amongst several other chemical series, the epoxi and ethylenesulfonamides (which are more stable) have been selected after that we have shown good filaricidal activities on the Filaria Molinema dessetae. This has been confirmed on other models. Good activity was observed with O. gutturosa adult male in vitro, while microfilariae of O. lienalis were insusceptible to the selected compounds. The future of these products was discussed, in the prospect of their development and in relation with their mode of action and the other available pharmacological data.
Gayral
P
P
Laboratoire de parasitologie, Faculté de pharmacie, Châtenay-Malabry.
D004353:Drug Evaluation, Preclinical; D005369:Filaricides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009855:Onchocerciasis / Q000188:drug therapy* / Q000517:prevention & control
D005369:Filaricides
La recherche de macrofilaricides dans le cadre de la lutte contre l'onchocercose africaine.