Increased multiplicity of lung adenomas in five generations of mice treated with benz(a)pyrene when pregnant.
The effect of benz(a)pyrene (BP) given to female mice of A strain on the 18 and 19th days of pregnancy was studied in 5 consecutive generations. As expected there was a high incidence of lung tumours (TBA%) in the F1-generation of mice treated with BP (53.9 vs. 15.4% in control in females and 77.6 vs. 8.0% in control in males). The percentage of TBA was not increased (with one exception) in both males and females of F2-F5 generations which were not directly exposed to carcinogen. Tumor multiplicity increase occurred not only in the F1 generation of BP-treated mice but in both males and females of F2-F5 generations of mice which were not in direct contact with the carcinogen. This increase was statistically significant. There was a slight negative trend within F2-F5 generation of BP-treated mice which however was not significant. Thus the transgenerational carcinogenic effect manifested in a greater tumour multiplicity persisted for four unexposed generations.
Turusov
V S
VS
Cancer Research Centre, USSR Academy of Medical Sciences, Moscow.
Nikonova
T V
TV
Parfenov YuD
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000453:epidemiology; D015994:Incidence; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D008297:Male; D051379:Mice; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D001564:Benzo(a)pyrene