title: [Variant angina which interacts with two phenomena: local hypersensitivity and abnormal response in the coronary tree to vasoconstrictor stimuli].
abstract: The aim of the present study was to evaluate the vasomotion of the entire coronary tree in variant angina, particularly focusing the attention on the behaviour of the "non spastic" epicardial vessels, using a quantitative coronary technique. Two different groups of patients served as controls. The first group consisted of 10 patients with accessory nodal pathway but without any sign of myocardial ischemia (Group I). The second group included 8 patients with stable exertional angina pectoris and coronary artery disease (Group II). The third group (Group III) consisted of 16 patients presenting with variant angina and spontaneous or hyperventilation-induced (HV: 30 cycles/min for 5 min) ST segment elevation. All patients underwent coronary angiography before and 2 min after HV testing; the evaluation of the coronary diameters was performed on baseline and after HV. In Group III, the HV testing caused a 26 +/- 12% reduction of the "non spastic" coronary vessels, with the mean control diameter of 2.00 +/- 0.61 mm that decreased to 1.48 +/- 0.55 mm. The patients of Group I showed only a mild degree of vasoconstriction (9 +/- 6%) of the epicardial coronary vessels; the Group II patients, also, showed a moderate response to vasoactive stimulus (11 +/- 8%), with the mean control diameter of 2.36 +/- 0.69 mm that decreased to 2.09 +/- 0.65 mm. The greater amount of vasoconstriction showed by patients with variant angina was statistically significant compared to both control groups (p less than 0.001). A further analysis of the coronary vasomotion, in Group III patients, showed that the 6 patients with normal or near normal coronary angiograms exhibited a 34% reduction in the vessel diameter. The remaining 10 patients who presented with a diffuse atherosclerotic involvement of the epicardial vessels (organic stenosis greater than or equal to 50% at the site of spasm) showed a lesser (20%) but yet significant extent of vasoconstriction compared to both control groups (p less than 0.001). In conclusion, our data indicate that: patients with variant angina exhibit a marked and diffuse coronary narrowing of the coronary vessels during vasoconstrictor stimuli; focal spasm occurs more frequently at the level of atherosclerotic coronary segments, whether they are critical or not. An interaction between these 2 phenomena, ie atherosclerosis and abnormal vasoconstriction, is supposed to be a cause of the occurrence of focal coronary spasm in variant angina.
authors: Istituto di Patologia Medica e Unità Coronarica, Università degli Studi, Bologna.
authors: F
authors: F
authors: Ottani
authors: R
authors: R
authors: Bugiardini
authors: G L
authors: GL
authors: Morgagni
authors: A
authors: A
authors: Pozzati
authors: A
authors: A
authors: Borghi
authors: P
authors: P
authors: Puddu
mesh_terms: D000328:Adult; D000788:Angina Pectoris, Variant / Q000503:physiopathology*; D000790:Angiocardiography; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D014661:Vasoconstriction / Q000502:physiology
vernacular_title: L'angina variante quale interazione tra 2 fenomeni: ipersensibilità locale ed abnorme risposta dell'albero coronarico agli stimoli vasocostrittori.