Assignment of the gene for central core disease to chromosome 19.
In a large kindred in which the gene for central core disease is segregating, we have demonstrated linkage between the disorder and a marker on chromosome 19q. Marker D19S9 (p1J2) was linked to central core disease with a lod score of 6.4 at theta = 0.03 (support interval 0.01-0.14) thus localizing the gene for this disorder in or very close to 19q12-q13.2.
Haan
E A
EA
Department of Medical Genetics, Adelaide Children's Hospital, Australia.
Freemantle
C J
CJ
McCure
J A
JA
Friend
K L
KL
Mulley
J C
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000235:genetics*; D010375:Pedigree; D015183:Restriction Mapping
D005819:Genetic Markers