Neutropenic enterocolitis in a patient with ovarian cancer after treatment with high-dose carboplatin and granulocyte macrophage-colony stimulating factor (GM-CSF).
A 50-yr-old women is described with relapsed ovarian cancer. She developed neutropenic enterocolitis after treatment with high-dose carboplatin (1000 mg/m2) and granulocyte macrophage-colony stimulating factor (GM-CSF). The clinical features and the pathogenesis of neutropenic enterocolitis are discussed. This case is the first report of neutropenic enterocolitis associated with the treatment of carboplatin.
Vlasveld
L T
LT
Department of Internal Medicine, The Netherlands Cancer Institute, Amsterdam.
Ten Bokkel Huinink
W W
WW
Rodenhuis
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004760:Enterocolitis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000008:administration & dosage; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy*
D016173:Macrophage Colony-Stimulating Factor; D016190:Carboplatin