Pentoxifylline attenuates edema formation in proteolytic enzyme-induced lung injury.
Ex vivo canine lung lobes were exposed to a pancreatic proteolytic enzyme (chymotrypsin) alone or chymotrypsin after pretreatment with a continuous infusion with pentoxifylline. The lobes exposed to chymotrypsin gained 133 g, while the pentoxifylline-treated lobes gained only 65 g (p less than .05) over the 3-h experimental period. These results suggest that pentoxifylline significantly attenuates the lung weight gain associated with chymotrypsin.
Rosenfeld
B A
BA
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD.
Toung
T J
TJ
Sendak
M J
MJ
Breslow
M J
MJ
Hutchins
G M
GM
Traystman
R J
RJ
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002918:Chymotrypsin / Q000009:adverse effects*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects
D002918:Chymotrypsin; D010431:Pentoxifylline