[Regulation of coronary circulation].
In the submitted review the author deals with specific features of the coronary circulation, coronary reserve and importance of regulation of the tonus of the coronary arteries at their epicardiac course and the tonus at the arteriolar level. In the subsequent part the author deals systematically first with the nervous regulation incl. the basic importance of the alpha-adrenergic (vasoconstrictor) and beta-adrenergic (vaso-dilating) sympathomimetic component. He mentions also the importance of neuropeptides (neuropeptide Y and substance P). Attention is devoted to the importance of the endothelium and endothelial vasoactive substances in the control of circulation. The main representatives of substances with a vasodilatating action are the endothelial relaxation factor and prostacycline, as to vasoconstrictor substances it is endothelin, thromboxan A2 and some growth factors. The authors discuss also the mechanical component, i. e. the influence of the blood flow and viscosity on the tonus of the coronary arteries. Finally the author draws attention to the clinical importance of disorders of regulatory mechanism in atherosclerosis and some clinical entities.
Bultas
J
J
II. interní katedra 1. lékarské fakulty Univerzity Karlovy, Praha.
D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D009479:Neuropeptides / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D009479:Neuropeptides
Regulace koronární cirkulace.