Monozygotic twins discordant for the Russell-Silver syndrome.
Russell-Silver syndrome is a disorder of unknown cause. A number of familial cases have suggested autosomal dominant inheritance. We report on monozygotic twins discordant for the Russell-Silver syndrome. Our findings suggest that the cause of Russell-Silver syndrome is not explained entirely by genetic factors. The possible role of the intrauterine environment as an etiologic component of Russell-Silver syndrome is discussed.
Samn
M
M
Department of Pediatrics, Children's Hospital of San Francisco, California 94118.
Lewis
K
K
Blumberg
B
B
D000015:Abnormalities, Multiple / Q000235:genetics*; D004200:Diseases in Twins / Q000235:genetics*; D004392:Dwarfism / Q000235:genetics*; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012886:Skull / Q000002:abnormalities; D013577:Syndrome; D014430:Twins, Monozygotic