Experimental study of radial ray deficiency.
The teratogenic mechanisms of radial ray deficiency were investigated. Radial ray deficiencies were induced in WKAH/Hkm rat foetuses by maternal administration of myleran on day 10, 10.5, or 11 of pregnancy. The skeletal anomalies in rats were similar to those in human beings, suggesting that exposure to some environmental factors at a sensitive period of embryogenesis may cause radial ray deficiency in humans. Ulnar ray deficiency has also been induced in rat foetuses by maternal administration of myleran, so it is suggested that radial deficiency and ulnar deficiency are caused by a common teratogenic mechanism in humans. However, the critical period for radial deficiency is one day later than that for ulnar deficiency in rats, which may contribute to the greater frequency of radial deficiency than ulnar deficiency in clinical cases.
Kato
H
H
Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Japan.
Ogino
T
T
Minami
A
A
Ohshio
I
I
D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D000818:Animals; D002066:Busulfan; D005552:Forelimb; D006801:Humans; D011884:Radius / Q000002:abnormalities*; D051381:Rats; D011919:Rats, Inbred Strains; D014034:Toes / Q000002:abnormalities*
D002066:Busulfan