Recurrence of anti-glomerular basement membrane antibody glomerulonephritis.
Recurrence of anti-glomerular membrane antibody glomerulonephritis seems to be an unusual clinical phenomenon. We report a 57-year-old man with recurrence of anti-glomerular basement membrane antibody glomerulonephritis. He developed a rapidly progressive glomerulonephritis with anti-glomerular basement membrane antibody (anti-GBM Ab), and recovered with a combined treatment of prednisolone, anticoagulant and antiplatelet agents. After a 2-year remission, hematuria and proteinuria followed by renal functional deterioration occurred without any obvious cause. The second renal biopsy revealed cellular crescents with linear IgG deposition along GBM, a finding similar to the first one. The aforementioned combined treatment resulted in a gradual recovery from proteinuria and renal functional derangement.
Kato
A
A
First Department of Medicine, Hamamatsu University School of Medicine, Japan.
Hishida
A
A
Kimura
M
M
Yoneyama
T
T
Arai
T
T
Honda
N
N
D000906:Antibodies; D001323:Autoantibodies; D003404:Creatinine / Q000097:blood; D004176:Dipyridamole / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011507:Proteinuria; D012008:Recurrence
D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D004176:Dipyridamole; D006493:Heparin; D011239:Prednisolone; D003404:Creatinine