The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells.
Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca2(+)-evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca2(+)-evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.
Bansal
M K
MK
Department of Biochemistry, University of Edinburgh, UK.
Phillips
J H
JH
van Heyningen
S
S
D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002478:Cells, Cultured; D007700:Kinetics; D009538:Nicotine / Q000494:pharmacology; D037342:Pertussis Toxin; D011189:Potassium Chloride / Q000494:pharmacology; D013744:Tetanus Toxin / Q000494:pharmacology*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D002395:Catecholamines; D013744:Tetanus Toxin; D010566:Virulence Factors, Bordetella; D011189:Potassium Chloride; D009538:Nicotine; D037342:Pertussis Toxin; D002118:Calcium