Hepatic metabolism of meal-fed rats: studies in vivo and in the isolated perfused liver.
Hepatic metabolic fluxes (glycolysis, glucose release, glycogenolysis, oxygen consumption, ketogenesis and gluconeogenesis), hepatic glycogen and food ingestion in meal-fed rats were measured and compared to appropriate controls. The following results were obtained: 1) in livers from meal-fed rats a higher fraction of glucosyl units derived from glycogen is used in glycolysis instead of being released in the form of glucose; 2) the rate of glycogen catabolism in livers from meal-fed rats is less than expected when one compares their glycogen levels with those of the appropriate controls; 3) the livers from meal-fed rats become much less ketotic than the livers from rats which were not trained to eat a single meal daily. It was concluded that the liver of meal-fed rats is well adapted to the main characteristics of those animals, e.g., increased lipogenesis from glycolysis products and a reduced need for carbon units from the liver (glucose and ketone bodies) as a consequence of enhanced food intake.
Bazotte
R B
RB
Laboratory of Liver Metabolism, University of Maringá, Paraná, Brazil.
Constantin
J
J
Hell
N S
NS
Bracht
A
A
D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D005943:Gluconeogenesis / Q000502:physiology; D006019:Glycolysis / Q000502:physiology; D008099:Liver / Q000502:physiology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011768:Pyruvate Dehydrogenase Complex / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D008112:Liver Glycogen; D011768:Pyruvate Dehydrogenase Complex