title: Inactivation of brown adipose tissue thermogenesis by oestradiol treatment in cold-acclimated rats.
abstract: Both cold-acclimated female rats and rats at thermoneutrality received 0.15-0.20 mg daily of 17 beta-oestradiol over 15 days via a Silastic capsule implanted subcutaneously. Controls received empty implants. Comparison between the oestradiol-treated animals and the untreated controls revealed that at thermoneutrality, oestradiol treatment decreased food intake and body weight gain, but did not affect brown adipose tissue (BAT) thermogenesis and composition. By contrast, in cold-acclimated rats, oestradiol treatment did not modify food intake or body weight gain, but it decreased BAT thermogenesis. It is concluded that the effects of oestradiol treatment on BAT depend on the activity of the tissue, i.e. it has no effect on BAT when the tissue is thermogenically inactive, but it decreases cold-induced BAT thermogenesis. It is suggested that oestradiol could be the hormonal factor responsible for the previously observed inactivation of BAT thermogenesis during pregnancy in cold-acclimated rats.
authors: Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Spain.
authors: M L
authors: ML
authors: Puerta
authors: M P
authors: MP
authors: Nava
authors: M
authors: M
authors: Abelenda
authors: A
authors: A
authors: Fernández
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003080:Cold Temperature; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004958:Estradiol