[The action of neural transplantation on the brain of rats with a damaged temporal cortex].
Possibilities of transplantation of embryonic brain tissue into the left temporal cortex of the host brain damaged by kainic acid (KA) were investigated. In the group of rats with KA-damaged temporal cortex tissue necrosis and considerable destructions in some structures far from the temporal cortex were revealed. The contralateral hemisphere also had greater area of sections than ipsilateral hemisphere in this group. In the group of rats with viable transplants (T) from E-21 in the temporal cortex damaged by KA the destructions in the same structures and hemisphere asymmetry were negligible, that evidenced for a positive effect of neural transplantation. T from E-15 after its implantation into the cortex of the host brain were pushed out from the cortex on the surface of the brain. These T caused intensification of the negative effect of the KA influence. It was supposed that viable T in the area of the damaged cortex inactivated exciting mediators in this region and also perhaps substituted partly damaged cortex after T had formed connections with the host brain.
Loseva
E V
EV
Ermakova
I V
IV
Tarasova
L Iu
LIu
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D016380:Brain Tissue Transplantation / Q000379:methods / Q000473:pathology; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000473:pathology*; D006085:Graft Survival / Q000187:drug effects; D007608:Kainic Acid / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D008845:Microinjections; D051381:Rats; D013702:Temporal Lobe / Q000187:drug effects / Q000196:embryology / Q000648:ultrastructure*
D007608:Kainic Acid
Deĭstvie neĭrotransplantatsii na mozg krys s povrezhdennoĭ visochnoĭ koroĭ.