title: The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.
abstract: Human corticosteroid binding globulin (CBG) cDNA fragments were radiolabeled and hybridized in situ to metaphase chromosome preparations. The results localized the CBG gene to the q31-q32.1 region of human chromosome 14. This location also contains the genes for two closely related serine protease inhibitors: alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin. It is therefore likely that these genes evolved by duplication events, and it would appear that this region contains a series of functionally related genes.
authors: Department of Obstetrics and Gynecology, University of Western Ontario, London, Canada.
authors: G E
authors: GE
authors: Seralini
authors: D
authors: D
authors: Bérubé
authors: R
authors: R
authors: Gagné
authors: G L
authors: GL
authors: Hammond
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007621:Karyotyping; D014156:Transcortin / Q000235:genetics*; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D014156:Transcortin