Use of amphotericin B in immunosuppressed patients with cancer. Part One: Pharmacology and toxicities.
Potentially fatal fungal infections account for most of the prolonged fevers found in immunosuppressed patients with cancer. Amphotericin B (AmB) is the most effective drug available to treat these infections. This article, Part One of two parts, reviews the biochemical properties of AmB and its dosage and administration. Major toxicities and common side effects are discussed. Part Two uses the pharmacodynamics addressed in Part One as a basis for planning nursing interventions to prevent or suppress adverse reactions.
Rutledge
D N
DN
Vanderbilt University School of Nursing, Nashville, TN.
Holtzclaw
B J
BJ
D000666:Amphotericin B / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D006224:Cricetinae; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology / Q000451:nursing; D009369:Neoplasms / Q000150:complications*; D009730:Nursing Assessment
D000666:Amphotericin B