title: The effect of topical cysteamine drops on reducing crystal formation within the cornea of patients affected by nephropathic cystinosis.
abstract: We studied the usefulness of topical cysteamine ophthalmic drops in reducing crystal formation within the corneas of patients affected by nephropathic cystinosis. A dosage of 0.3% cysteamine given four times daily was chosen as a more manageable method than a previously reported protocol of hourly administration of 0.11% drops. No reduction in crystal formation was observed in our patients; they were followed for seven months.
authors: Department of Biochemistry, University of Ottawa, Ontario, Canada.
authors: I M
authors: IM
authors: MacDonald
authors: L P
authors: LP
authors: Noel
authors: G
authors: G
authors: Mintsioulis
authors: W N
authors: WN
authors: Clarke
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology; D003460:Crystallization; D003543:Cysteamine / Q000008:administration & dosage / Q000627:therapeutic use*; D003554:Cystinosis / Q000150:complications*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D011379:Prognosis; D014792:Visual Acuity
chemical_list: D003543:Cysteamine