[Treatment of ectopic pregnancy using methotrexate].
The authors applied the conservative treatment of ectopic pregnancy with methotrexate in a prospective study comprising 22 patients. Out of this number, 14 patients had intact ectopic pregnancy and 8 showed the signs of initial tubal abortion (as proved by the hematocele finding). This group of 8 patients insisted to be given the same therapy, although they were informed of the possible failure in cases of initial tubal abortion. In all these cases methotrexate was administered locally, injected into the gestational sac under ultrasonic monitoring. In addition to the local application, 13 patients systemically received the same drug in pills (2.5 mg). At the same time, all the patients were given the antidote (Citrovorum factor). This method of treatment appeared to be successful in 16 patients (72.7%), four of them also having hematocele. Surgical treatment was applied afterwards in six patients (27.3%).
Pilić
Z
Z
Ginekolosko akuserska Klinika klinickog centra, Beogradu.
Juznić
N
N
Radosavljević
A
A
Pantović
D
D
D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D011446:Prospective Studies; D014463:Ultrasonography
D008727:Methotrexate
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