Pharmacokinetic drug interactions with cyclosporin (Part II).
Part I of this article, which appeared in the previous issue of the Journal, considered the potential mechanisms of drug interactions with cyclosporin, and divided the interacting drugs into 2 categories. Drugs that decrease cyclosporin concentrations (e.g. anti-convulsants, rifampicin, etc.) were dealt with first; the authors then moved on to consider the second category, those that increase cyclosporin concentration (macrolide antibiotics, azole antifungal drugs). Part II continues the survey of this category.
Yee
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GC
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville.
McGuire
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TR
D002121:Calcium Channel Blockers / Q000493:pharmacokinetics; D003524:Cyclosporins / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans
D002121:Calcium Channel Blockers; D003524:Cyclosporins