title: [Histocompatibility antigens and acute vascular purpura].
abstract: BACKGROUND
  Some kidney diseases are associated to HLA antigens. Nyulassy found an increase in HLA-B35 in patients with Henoch-Schönlein's purpura suffering nephritis (HSP-N). Our study searched for associations of HLA antigens and anaphylactoid purpura nephritis in Mexican mestizo patients.
  
  
  METHODS
  HLA-A,B, and C antigens were detected by two-step microcytotoxicity in 22 patients with HSP-N and compared to those of 665 healthy subjects of the same ethnic background.
  
  
  RESULTS
  A significant association was found between HSP-N and HLA-Aw19 single (pc less than 0.05) or in haplotype form (Aw19-B35) (pc less than 0.005). HLA B35 alone was associated to HSP-N but only at non corrected level (pc less than 0.05).
  
  
  CONCLUSIONS
  The significant association between HLA-Aw19 and Aw19-B35 and HSP-N may indicate a risk factor in Mexican mestizo patients to develop this case.
authors: División de Inmunología, Unidad de Investigación Biomédica, Centro Médico Nacional, Instituto Mexicano del Seguro Social, D.F.
authors: J
authors: J
authors: Arellano
authors: S
authors: S
authors: Ojeda
authors: R
authors: R
authors: Vargas
authors: C
authors: C
authors: Zavala
authors: D
authors: D
authors: Santos
authors: A
authors: A
authors: López
authors: R
authors: R
authors: Kretschmer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000208:ethnology; D008297:Male; D008800:Mexico
chemical_list: D006680:HLA Antigens
vernacular_title: Antígenos de histocompatibilidad y púrpura vascular aguda.