[Changes in the functional properties of NK-cells and the cytostatic activity of granulocytes in acute leukemia patients].
Effector activity of natural killers (NK) was studied, and functional state of NK and granulocytes was evaluated in 23 normal subjects and 28 acute leukemia patients (12 of them being in clinico-hematological remission up to 2 years). In acute leukemia significant disorders are observed in the system of nonspecific antitumor defence that is evidenced by a drastic decrease of NK activity due to changes in the functional properties of NK--their capacity for producing conjugates and blast cell lysis, low sensitivity to exogenous interferon, and lowered spontaneous cytostatic of granulocytes.
Vartanian
N L
NL
Luganova
I S
IS
Blinov
M N
MN
D000208:Acute Disease; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000276:immunology*
Izmenenie funktsional'nykh svoĭstv NK-kletok i tsitostaticheskoĭ aktivnosti granulotsitov u bol'nykh ostrym leĭkozom.