Introduction: B27-associated diseases.
As an introduction, a hypothesis for the causation of ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and rheumatoid arthritis is outlined. It comprises ten basic mechanisms. With that hypothesis as a background, a further ten issues based on clinical evidence are presented for discussion. Finally, four questions are presented on behalf of the clinicians.
Brewerton
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Department of Therapeutics, Charing Cross and Westminster Medical School, London, U.K.
D001170:Arthritis, Infectious / Q000276:immunology; D015535:Arthritis, Psoriatic / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000276:immunology
D015796:HLA-B27 Antigen