A tribute to the late Dr. Ryo Shimazu: a chronic bowel allograft model in the rat.
A chronic model of bowel allotransplantation is described. End-to-end microvascular anastomosis between superior mesenteric vessels was utilized. The recipient splenic vein was preserved to avoid postoperative pancreatitis. Euro-Collins solution was used to flush the vasculature in the lumen of the transplant. Low-dose cyclosporine was used for immunosuppression. With experience, 89% long-term survival was achieved.
Shimazu
R
R
Department of Surgery/Transplantation, University of Mississippi Medical Center, Jackson 39216-4505.
Raju
S
S
Grogan
J B
JB
D000714:Anastomosis, Surgical; D000818:Animals; D002432:Cecum / Q000601:surgery; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004386:Duodenum / Q000637:transplantation; D006085:Graft Survival; D049673:History, 20th Century; D007421:Intestine, Small / Q000637:transplantation*; D008638:Mesenteric Arteries / Q000601:surgery; D008642:Mesenteric Veins / Q000601:surgery; D008866:Microsurgery / Q000266:history / Q000379:methods*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D003524:Cyclosporins