Chronic testosterone propionate treatment decreases the concentration of [3H]quipazine binding at 5-HT3 receptors in the amygdala of the castrated male rat.
Chronic administration of testosterone propionate (TP) was found to decrease the concentration of [3H]quipazine binding at 5-HT3 receptors in the lateral and basal amygdaloid nuclei of the brains of castrated male rats. TP had no effect on the binding of [3H]quipazine at 5-HT3 receptors in the posterolateral or posteromedial cortical amygdaloid nuclei, or in the amygdalohippocampal areas. It is suggested that the effects of testosterone on sexual and other social behaviors in male rats may be mediated, at least in part, by decreases in the activation of 5-HT3 receptors in the amygdala.
Mendelson
S D
SD
Department of Neuroendocrinology, Rockefeller University, New York, NY 10021.
McEwen
B S
BS
D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D008297:Male; D009919:Orchiectomy; D011814:Quipazine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors; D014316:Tritium
D011985:Receptors, Serotonin; D014316:Tritium; D013739:Testosterone; D011814:Quipazine