[Significance of the circulating antibodies in patients with interstitial lung disease].
Indirect immunofluorescent study was proceeded in 86 cases of interstitial lung disease by using human fetal lung as the target organ. 2 kinds of antibodies were found. One was type I or III anticollagen antibody, the positive rate in IPF was the highest, 63%. The other was antinuclear antibody (ANA). 8 cases were positive. Both of the antibodies may play active role in the pathogenesis of IPF. The authors suggest that assessment of the antibodies to college type L & III by immunofluorescent method might be helpful in the diagnosis of IPF.
Jiang
X F
XF
Peking Union Medical College Hospital, Beijing.
D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D003094:Collagen / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008171:Lung Diseases / Q000276:immunology; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D003094:Collagen