[The cytotoxic activity of natural killer cells exposed to the joint and separate actions on the body of 239Pu, hexachlorobutadiene and tributyl phosphate].
Wistar rats were subjected to a single exposure to 239Pu nitrate through inhalation with the subsequent procedure of imitation of inhalation or without it (the amount of 239Pu deposited in the lungs in 24 hr was 8.9 +/- 1.9 kBq/lung) and inhalation of hexachlorobutadiene and tributyl phosphate within one month in a combination with the radionuclide or without it. There was a 1.5-fold increase, above additive, in the harmful effect of 239Pu and chemical agents on the function of natural killers as observed 15--30 days after the combined exposure as compared to individual inhalation. On days 120 to 240 cell cytotoxic activity in rats of all groups was normalized to reach or to exceed the intact control.
Kirillova
E N
EN
Chudin
V A
VA
Okatenko
M A
MA
D000280:Administration, Inhalation; D000818:Animals; D002070:Butadienes / Q000008:administration & dosage*; D003602:Cytotoxicity, Immunologic; D007202:Indicators and Reagents / Q000008:administration & dosage; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D009566:Nitrates; D010755:Organophosphates / Q000008:administration & dosage*; D011005:Plutonium / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D002070:Butadienes; D007202:Indicators and Reagents; D009566:Nitrates; D010755:Organophosphates; C015459:plutonium nitrate; D011005:Plutonium; C009524:tributyl phosphate; C001335:hexachlorobutadiene
Tsitotoksicheskaia aktivnost' natural'nykh killerov pri sovmestom i razdel'nom deĭstvii na organizm 239Pu, geksakhlorbutadiena i tributilfosfata.