Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide.
Nagasawa
H T
HT
Medical Research Laboratories VA Medical Center, Minneapolis, Minnesota 55417.
DeMaster
E G
EG
Redfern
B
B
Shirota
F N
FN
Goon
D J
DJ
D000079:Acetaldehyde / Q000097:blood; D000427:Alcohol Deterrents / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors; D001711:Biotransformation; D002374:Catalase / Q000378:metabolism*; D003484:Cyanamide / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008930:Mitochondria, Liver / Q000201:enzymology; D009589:Nitrogen Oxides / Q000378:metabolism*
D000427:Alcohol Deterrents; D009589:Nitrogen Oxides; D003484:Cyanamide; D002374:Catalase; D000444:Aldehyde Dehydrogenase; C039900:nitroxyl; D000079:Acetaldehyde