[The cultivation and physicochemical properties of the Josiah strain of the Lassa virus].
Data on the stability of Lassa virus, Josia strain, isolated from man to the effect of physicochemical factors (heating at 50 degrees C, solutions of urea and formalin of various concentrations, UV irradiation) as well as on the time course of this strain reproduction in cell lines of different origins are presented. Recommendations for lowering of reactogenicity of the virus-containing material are given. The experimental results must be taken into consideration in the development and manufacture of diagnostic and therapeutic-prophylactic preparations for Lassa fever.
Fidarov
F M
FM
Surikova
L E
LE
Erofeeva
N I
NI
Klimashevskaia
L M
LM
Petkevich
A S
AS
Lukashevich
I S
IS
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000494:pharmacology; D007836:Lassa virus / Q000187:drug effects / Q000254:growth & development* / Q000528:radiation effects; D051379:Mice; D012692:Serial Passage; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication
D003470:Culture Media; D005557:Formaldehyde
Kul'tivirovanie i fiziko-khimicheskie svoĭstva virusa Lassa shtamm Dzhoziia.