[Synthesis and biological activity of aminophenylphosphonic derivatives of levorin].
Reactions of levorin, a polyenic macrolide antibiotic, with aromatic aldehydes and hypophosphorous acid resulted in formation of its amino phenylphosphonium derivatives. Physicochemical and biological properties of the derivatives were studied. The levorin amino phenylphosphonium derivatives were shown to be low toxic and have antifungal and antiviral activities.
Belakhov
V V
VV
Levina
A A
AA
Shenin
Iu D
IuD
Ionin
B I
BI
Shatik
L I
LI
Zaĭtseva
M B
MB
Grinberg
G E
GE
Shtil'bans
E B
EB
Rachkovskaia
L A
LA
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D002174:Candicidin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005658:Fungi / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D014777:Virus Diseases / Q000188:drug therapy* / Q000382:microbiology; D014780:Viruses / Q000187:drug effects*
D000447:Aldehydes; D000588:Amines; D063065:Organophosphonates; D002174:Candicidin
Poluchenie i biologicheskaia aktivnost' aminofenilfosfonistykh proizvodnykh levorina.