Influence of aging on ethanol and acetaldehyde oxidation in female rat liver.
Rates of ethanol metabolism by alcohol dehydrogenase, the microsomal ethanol oxidizing system (MEOS), and catalase were similar in liver preparations from young (4-5 months) and old (24-27 months) female Fischer 344 rats. On the other hand, rates of acetaldehyde metabolism by mitochondrial aldehyde dehydrogenase (ALDH) were 15-20% lower in livers of old rats than in those of younger ones. Results with the ALDH inhibitor cyanamide indicated that a decline in ALDH activity of this magnitude would not increase acute ethanol hepatotoxicity.
Rikans
L E
LE
Department of Pharmacology, University of Oklahoma College of Medicine, Oklahoma City.
Snowden
C D
CD
Moore
D R
DR
D000079:Acetaldehyde / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003484:Cyanamide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D051381:Rats; D011916:Rats, Inbred F344
D000431:Ethanol; D003484:Cyanamide; D003577:Cytochrome P-450 Enzyme System; D000429:Alcohol Oxidoreductases; C092153:microsomal ethanol-oxidizing system; D000426:Alcohol Dehydrogenase; C019642:alcohol dehydrogenase (NADP+); D002374:Catalase; D000444:Aldehyde Dehydrogenase; D005969:Glutamate Dehydrogenase; D000079:Acetaldehyde