Studies on non-steroidal anti-inflammatory and related biological activities of 5-(indan-1'-yl)tetrazoles and their intermediates.
Anti-inflammatory, analgesic and anti-pyretic activities of three new 5-(Indan-1'-yl)tetrazoles and anti-inflammatory activity of corresponding carboxamides were compared to those of standard drugs, phenylbutazone and aspirin. The results indicated 5-(Indan-1'-yl)tetrazole as the most promising compound in chronic anti-inflammatory and anti-pyretic tests.
Ray
S M
SM
Department of Pharmaceutical Technology, Jadavpur University, Calcutta.
Roy
A
A
Lahiri
S C
SC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000503:physiopathology; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy / Q000503:physiopathology; D007189:Indans / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D013777:Tetrazoles / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans; D013777:Tetrazoles; D002351:Carrageenan; D010653:Phenylbutazone; D001241:Aspirin