title: Subrepeats result from regional DNA sequence conservation in tandem repeats in Chironomus telomeres.
abstract: Repeat units, widespread in eukaryotic genomes, are often partially or entirely built up of subrepeats. Homogenization between whole repeat units arranged in tandem usually can best be understood as a result of unequal crossing over. Such a mechanism is less plausible for maintaining similarities between subrepeats within a repeat unit when present in a regular array. In Chironomus telomeres, large blocks of tandemly repeated approximately 350 base-pair units contain two or three pairs of subrepeats with high mutual identities, embedded in linker DNA, non-repetitive within the repeat unit. Measurements of evolutionary base changes in two closely related species, Chironomus tentans and Chironomus pallidivittatus, permit us to conclude that the subrepeat arrangement is best explained as a consequence of regional sequence conservation after an earlier duplication of an ancestral half-unit.
authors: Department of Genetics, Lund, Sweden.
authors: L
authors: L
authors: Nielsen
authors: E R
authors: ER
authors: Schmidt
authors: J E
authors: JE
authors: Edström
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002683:Chironomidae / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D015698:Genomic Library; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004247:DNA