title: Percutaneous transhepatic gallstone dissolution with methyl tert-butyl ether in complicated stone diagnosis and gallbladder anomalies.
abstract: In a total of 117 successfully punctured patients with gallbladder stones that were to be treated with methyl tert-butyl ether, 11 showed shell-like structured concrements on the CT scan. In 2 patients, pigment stones and very old concrements were suspected. In these 13 patients solitary stones dissolved in 2.9 hours, multiple stones in 10.8 hours, which corresponds to the treatment time of the total group. In 4 patients we diagnosed cholesterol stones, but dissolution was very slow, suggesting that the stones were covered with pigment. In 21 patients we found marked gallbladder anomalies, such as extreme septation, two-chamber gallbladders, gallbladder diverticula with a wedged stone, or gallbladders in which the fundus was positioned cranially. In these patients puncture time was prolonged by 25%. However, since in all patients the stones dissolved in the same time as in the total group (solitary stones; 3.1 hours: multiple stones: 10.4 hours) and since in 33% there was also sludge in the gallbladder, shape variants of the gallbladder obviously have no influence on the stone type. Whether they induce recurrent stones more often than normal gallbladders cannot be assessed at present. Shape variants of the gallbladder and layered stones on CT scan, however, do not represent a contraindication to MTBE therapy.
authors: Department of Gastroenterology, Johann Wolfgang Goethe University, Frankfurt/Main, FRG.
authors: A
authors: A
authors: Hellstern
authors: D
authors: D
authors: Rübesam
authors: M
authors: M
authors: Leuschner
authors: T
authors: T
authors: Wendt
authors: H
authors: H
authors: Fuchs
authors: U
authors: U
authors: Leuschner
mesh_terms: D002765:Cholecystography; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000628:therapy*; D000075202:Contraindications; D004987:Ethers / Q000627:therapeutic use*; D005704:Gallbladder / Q000002:abnormalities* / Q000000981:diagnostic imaging; D006801:Humans; D008738:Methyl Ethers; D011677:Punctures; D012997:Solvents / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D004987:Ethers; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether