Comparison of the effect of topical corticosteroids and nonsteroidals on postoperative corneal astigmatism.
A controlled study compared the effects of a topical steroid (1% prednisolone acetate) and a topical nonsteroidal anti-inflammatory agent (0.03% flurbiprofen) on postoperative changes in corneal astigmatism in a series of patients having phacoemulsification and posterior chamber lens implantation through a 6.5 mm scleral pocket incision. The incisions were closed with a continuous running 10-0 monofilament nylon suture under tonometric and keratometric control. The results of the study showed that both agents demonstrated similar postsurgical astigmatic decay curves; however, the group receiving the nonsteroidal agent had an earlier decay of iatrogenically induced astigmatism. Approximately 80% of cases receiving the nonsteroidal agent completed the postoperative course without the use of topical steroids, indicating that in some cases steroids may be avoided after cataract removal.
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D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001251:Astigmatism / Q000188:drug therapy* / Q000209:etiology; D002387:Cataract Extraction; D003315:Cornea / Q000187:drug effects*; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D011182:Postoperative Care; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005480:Flurbiprofen; C009935:prednisolone acetate; D011239:Prednisolone