[Cardiovascular pharmacology. An example of the need of clinically relevant pharmacological research].
Like all other scientific disciplines, preclinical pharmacological research is subject to permanent changes. New measuring devices and the possibility of continuous on line data acquisition have markedly influenced basic research in this field. Another aim of modern cardiovascular pharmacology is the testing of promising drugs in clinically relevant animal models of disease, particularly under conditions, referring to the everyday situation in patients, e.g. physical activity. Investigations carried out in this way allow an exact assessment of the clinical efficacy of new drugs, and are, thus, clearly indispensable, also from the ethical point of view, before primary evaluation of the drug in man.
Raberger
G
G
Pharmakologisches Institut, Universität Wien.
Krumpl
G
G
Fischer
G
G
Grohs
J G
JG
Todt
H
H
Krejcy
K
K
Huber
S
S
Brugger
G
G
Karel
A
A
Krivanek
P
P
D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001317:Austria; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002415:Cats; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004554:Electric Countershock; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy; D010600:Pharmacology; D051381:Rats; D012106:Research
D002317:Cardiovascular Agents
Herz- und Kreislaufpharmakologie. Ein Beispiel der Notwendigkeit kliniknaher pharmakologischer Forschung.