title: Prevention of coccidiosis in the chukar partridge (Alectoris chukar) by medication with sulfadimethoxine and ormetoprim (Rofenaid).
abstract: Rofenaid (a 5:3 mixture of sulfadimethoxine and ormetoprim) was effective in preventing coccidiosis of chukar partridges. Levels of .0100 or .0125% sulfadimethoxine, with the corresponding level of ormetoprim in the ration, gave the best results. These levels markedly reduced mortality in severe infections (over 75% mortality in unmedicated chukars) and eliminated mortality in medicated groups when infections produced 52% mortality or less in unmedicated controls. In the latter infections, Rofenaid also protected against the depression in weight gain seen 6 days postinoculation in unmedicated chukars. Studies in uninoculated chukars showed that Rofenaid has a wide safety margin and did not produce adverse effects even at levels of .0300% sulfadimethoxine. Rofenaid should, therefore, be an effective medication for the prevention of coccidiosis in chukars in the field. Data from the present studies are being submitted to the IR-4 Program of the Food and Drug Administration for consideration of approval for the use of Rofenaid in chukar partridges.
authors: Livestock and Poultry Sciences Institute, USDA, Beltsville, Maryland 20705.
authors: M D
authors: MD
authors: Ruff
authors: G C
authors: GC
authors: Wilkins
mesh_terms: D000821:Animal Feed; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D004338:Drug Combinations; D011200:Poultry; D011201:Poultry Diseases / Q000517:prevention & control*; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D013412:Sulfadimethoxine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D011743:Pyrimidines; C003275:ormetoprim, sulfadimethoxine drug combination; D013412:Sulfadimethoxine