Haemolytic crises due to glucose-6-phosphate dehydrogenase deficiency in the mid-southern region of Turkey.
Clinical and laboratory evaluation of 60 boys with hemizygous, 12 girls with homozygous, and 11 girls with heterozygous erythrocyte glucose-6-phosphate dehydrogenase deficiency was made during haemolytic crisis. The main clinical symptoms were paleness, dark urine and oliguria. Only one patient needed peritoneal dialysis. Coexistence of glucose-6-phosphate dehydrogenase deficiency associated with haemoglobinopathy was found to be higher than expected (32 out of 83 cases). Also, the high prevalence of glucose-6-phosphate dehydrogenase deficiency among females with homozygous and heterozygous disease was surprising. The precipitating factors of haemolysis were variable. Rather than antimalarial and antipyretic-analgesic drugs, infections seemed to be the main haemolytic factor.
Kilinç
Y
Y
Department of Paediatrics, Medical Faculty of Cukurova University, Adana, Turkey.
Kümi
M
M
D000208:Acute Disease; D000293:Adolescent; D000743:Anemia, Hemolytic / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D006453:Hemoglobinopathies / Q000150:complications; D006801:Humans; D007223:Infant; D008297:Male; D014421:Turkey / Q000453:epidemiology