Migraine, serum serotonin and platelet 5-HT2 receptors.
In spite of recent theories about the aetiopathogenesis of migraine, serotonin continues to play a central role, explaining the efficacy of almost all migraine prophylactic drugs. In migraineurs with and without aura we measured (by HPLC-EC) the serum serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels between as well as during headache attacks. Between attacks of migraine with aura and at the beginning of attacks of both types of migraine the serum 5-HT and 5-HIAA concentration was significantly increased. These results were corroborated by 3H-spiperone binding to platelet membranes: in migraineurs with aura in the attack-free interval, there was a significant decrease in its Bmax, which suggests down-regulation of 5-HT2 receptors. In conclusion, we have verified that migraine with aura differs biochemically from migraine without aura.
Ribeiro
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CA
Instituto de Farmacologia e Terapêutica Experimental, Faculdade de Medicina, Universidade de Coimbra.
Cotrim
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MD
Morgadinho
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Ramos
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Santos
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de Macedo
T dos R
Tdos R
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D002648:Child; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D010974:Platelet Aggregation; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000097:blood*; D012701:Serotonin / Q000097:blood*
D011985:Receptors, Serotonin; D012701:Serotonin