[Effects of low doses of activated protein C in experimental arterial thrombosis in rats].
Activated C protein (ACP) is a physiological anticoagulant enzyme that is capable to inactivate factors Va and VIIIa, thereby having a wide spectrum of antithrombotic effects. Low-dose ACP was tested for its ability to affect anodic current-induced arterial thrombosis in the rat. ACP given in low doses (15 micrograms/kg, 7% of total C protein in the rat) was found to produce a marked antithrombotic effect. With this, the activated partial thromboplastin time remained virtually unchanged, and its antithrombotic action was equal to that of heparin administered in a dose of 125 U/kg. In the authors' opinion, ACP may form the basis for designing a highly effective antithrombotic agent.
Pyzh
M V
MV
Smirnov
M D
MD
Borovikov
D V
DV
Dobrovol'skiĭ
A B
AB
Storozhilova
A N
AN
Golubykh
V L
VL
Gratsianskiĭ
N A
NA
D000818:Animals; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000008:administration & dosage*; D051381:Rats; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D011486:Protein C; D006493:Heparin
Vliianie malykh doz aktivirovannogo proteina C na éksperimental'nyĭ arterial'nyĭ thromboz u krys.