[The heterogeneity of an influenza virus A population in its capacity to induce the synthesis of avid antibodies].
Influenza A virus variants were found to be capable of inducing synthesis of avid antibodies when different species and lines of animals were immunized. CBA mice were the most convenient model permitting differentiation of "avidogenic" from "nonavidogenic" virus variants with a high degree of certainty. Recombinants may differ from parental viruses in their capacity to induce synthesis of avid antibody; with this, the transmission of only one gene (HA) from the "avidogenic" parent into the system of genes of A/PR/8/34 st in ensured a high "avidogenicity" of the recombinant. The "avidogenic" virus variants had a more marked protective effect than "nonavidogenic" ones.
Kolotvinov
S V
SV
Akhmetova
L I
LI
Manova
I P
IP
Galitarov
S S
SS
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D000915:Antibody Affinity / Q000276:immunology*; D014644:Genetic Variation / Q000276:immunology; D007114:Immunization / Q000379:methods; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D011919:Rats, Inbred Strains; D012692:Serial Passage; D013045:Species Specificity
D000914:Antibodies, Viral
Geterogennost' populiatsii virusa grippa A po sposobnosti indutsirovat' sintez avidnykh antitel.