Clinical results and the Essen concept of TBI.
Total body irradiation (TBI) prior to bone marrow transplantation (BMT) is applied for treatment of 230 patients in the period 1975-1988. The clinical results of 169 patients treated by four different TBI dosage and treatment techniques are analysed. The risk of leukemic relapse is low after fractionated TBI (9%) as well as after single dose TBI (14%). The lowest frequency of interstitial pneumonitis (21%) occurred when the patient translation technique was used for fractionated homogeneous pa/ap TBI with 10 Gy (8 Gy lung dose) in 4 fractions in 4 days. Prophylaxis of GVHD and the modus of protective environment were two other factors which influence the risk of IP.
Molls
M
M
Department of Radiotherapy, West German Tumour Centre, University Hospital, Essen.
Quast
U
U
Schaefer
U W
UW
Szy
D
D
Beelen
D W
DW
Quabeck
K
K
Graeven
U
U
Sayer
H G
HG
Bamberg
M
M
Sack
H
H
D000328:Adult; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000532:radiotherapy* / Q000601:surgery; D011658:Pulmonary Fibrosis / Q000453:epidemiology; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*