title: Lactic acidosis with hypoglycemia and hyperammonemia observed in two uremic patients during calcium hopantenate treatment.
abstract: Calcium hopantenate (HOPA), a drug for treating symptoms of cerebrovascular disease, is a derivative of gamma-amino butyric acid and is also an analog of pantothenic acid. It is speculated that calcium hopantenate may affect lactate generation, glucose metabolism, and ammonia disposal through the inhibition of pantothenic acid metabolism. We report two uremic patients with complaints of consciousness disturbance with lactic acidosis, hypoglycemia and hyperammonemia. HOPA is mainly excreted with urine. Severe accumulation of HOPA, documented at the onset of unconsciousness in our uremic cases, might be responsible for marked inhibition of pantothenic acid metabolism.
authors: Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors: M
authors: M
authors: Otsuka
authors: T
authors: T
authors: Akiba
authors: Y
authors: Y
authors: Okita
authors: K
authors: K
authors: Tomita
authors: N
authors: N
authors: Yoshiyama
authors: T
authors: T
authors: Sasaoka
authors: M
authors: M
authors: Kanayama
authors: F
authors: F
authors: Marumo
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D000641:Ammonia / Q000097:blood*; D002331:Carnitine / Q000097:blood; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D014511:Uremia / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
chemical_list: C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D000641:Ammonia; D002331:Carnitine