Infertility in human males with autosomal translocations: meiotic study of a 14;22 Robertsonian translocation.
Pachytene analysis was undertaken in a male patient heterozygous for a 14q22q Robertsonian translocation. The relatively low rate of XY autosome association led us to examine the relationships existing between the chromosomes involved in the translocation, the rate of XY-autosome association and the degree of spermatogenic failure. Cytogenetic investigations in infertile men and the results of the meiotic studies suggest a direct correlation between the frequency of XY-autosome association at pachytene and the degree of spermatogenic failure. Whether associations arise as a consequence or cause of germ cell failure is still not certain.
Guichaoua
M R
MR
Département d'Embryologie et de Cytogénétique, Faculté de Médecine, Marseille, France.
Quack
B
B
Speed
R M
RM
Noel
B
B
Chandley
A C
AC
Luciani
J M
JM
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008540:Meiosis; D013094:Spermatozoa / Q000473:pathology / Q000648:ultrastructure; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome