title: An immunohistochemical study of the distribution of matrical proteins in the mandibular condyle of neonatal mice. I. Collagens.
abstract: This study provides new information concerning the distribution of cartilage collagens in neonatal mammalian condylar cartilage. It became apparent that young cartilage cells contain pro-Type I collagen as well as pro-Type II collagen. The mature molecule of Type I collagen appears only in the extracellular matrix of the mineralisation zone close to the ossification front. Type II collagen, on the other hand, is apparent throughout the extracellular matrix as soon as the chondroprogenitor cells have differentiated into chondroblasts. In addition, Type II collagen is noticed in the core of the newly formed bone trabeculae within the primary spongiosa. Type IX collagen was found to be co-distributed with Type II collagen in cartilage and bone. Hypertrophic chondrocytes within the mineralisation zone, but in no other zone, demonstrate an intense reactivity for Type X collagen. Mild reactivity throughout the condylar process is encountered with regard to Type VI collagen. Perichondrium but not cartilage reacts positively for Type III collagen.
authors: Laboratory for Musculoskeletal Research, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel.
authors: M
authors: M
authors: Silbermann
authors: K
authors: K
authors: von der Mark
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D000906:Antibodies; D003094:Collagen / Q000032:analysis* / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D008335:Mandibular Condyle / Q000033:anatomy & histology / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR / Q000033:anatomy & histology / Q000378:metabolism
chemical_list: D000906:Antibodies; D003094:Collagen