Orosomucoid (ORM) typing by isoelectric focusing: an analysis of ORM haplotypes.
A new separator isoelectric focusing method for typing of orosomucoid (ORM) was developed. This method provided a superior resolution of ORM patterns: two close bands of ORM1*5.2 products were clearly separated. A total of 364 subjects from Okinawa (Japan) were classified into 21 ORM phenotypes determined by 6 ORM1 and 7 ORM2 alleles including a polymorphic silent allele, ORM2*QO, and 2 new rare variants, ORM2*18 and ORM2*19. These phenotypes were also explained by 12 ORM haplotypes, half of which were polymorphic.
Yuasa
I
I
Department of Legal Medicine, Tottori University School of Medicine, Yonago, Japan.
Umetsu
K
K
Suenaga
K
K
Iha
M
M
Hirata
H
H
Ikebuchi
J
J
D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007525:Isoelectric Focusing; D007564:Japan; D009961:Orosomucoid / Q000235:genetics*; D011110:Polymorphism, Genetic
D009961:Orosomucoid