The parental origin of de novo X-autosome translocations in females with Duchenne muscular dystrophy revealed by M27 beta methylation analysis.
The parental origin of 3 de novo X-autosome translocations in females with Duchenne Muscular Dystrophy (DMD) was studied by means of methylation analysis using the X-linked probe M27 beta. In all three the translocation was found to be paternal in origin. The parental origin of X-autosome translocations in females with and without DMD is compared with other structural abnormalities of the X and with autosomal translocations.
Robinson
D O
DO
Wessex Regional Genetics Laboratory, General Hospital, Salisbury.
Boyd
Y
Y
Cockburn
D
D
Collinson
M N
MN
Craig
I
I
Jacobs
P A
PA
D000818:Animals; D015139:Blotting, Southern; D002460:Cell Line; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D008745:Methylation; D051379:Mice; D009136:Muscular Dystrophies / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome