Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons.
Wallerian degeneration is delayed following sciatic nerve crush in C57BL/Ola mice. Compared to C57BL/6J mice, regeneration of sensory axons is significantly slowed in the Ola mice, but reinnervation does eventually occur. We conclude that Wallerian degeneration is a prerequisite for normal sensory axon regeneration following a crush injury to peripheral nerve.
Bisby
M A
MA
Department of Physiology, Queen's University, Kingston, Ontario, Canada.
Chen
S
S
D000818:Animals; D001369:Axons / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology*; D013045:Species Specificity; D014855:Wallerian Degeneration / Q000502:physiology*