[Effect of verapamil, a calcium antagonist, on the gastric secretion stimulated by histamine or sham-feeding].
While "in vitro" studies suggest that cholinergic but not histamine stimulation of the parietal cell is closely related to the flow of extracellular Ca++ into the cell, human studies show a great deal of discrepancy. We evaluated the effects of verapamil, a Ca++ channel antagonist, on gastric secretion stimulated by histamine and sham feeding in 19 patients with duodenal ulcers. Verapamil (200 mcg/kg/h in continuous perfusion) had no effect either on acid production or the volume of secretion in 10 duodenal ulcer patients during simultaneous perfusion of three progressive doses of histamine. However, it significantly inhibited both SAO (51.83%; p less than 0.01) and the volume of secretion in the sham feeding period (28.39%; p less than 600.05), in a group of nine duodenal ulcer patients. These findings suggest that the Ca++ acts as an intracellular mediator in the stimulation/secretion relationship for cholinergic but not histaminergic stimulation in humans.
Hinojosa
J
J
Servicio de Medicina Interna, Hospital de Sagunto, Valencia.
Primo
J
J
D000109:Acetylcholine / Q000502:physiology; D000328:Adult; D002118:Calcium / Q000502:physiology*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology; D004435:Eating / Q000502:physiology*; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology*; D015290:Second Messenger Systems / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D006632:Histamine; D014700:Verapamil; D010418:Pentagastrin; D000109:Acetylcholine; D002118:Calcium
Efecto del verapamil, un antagonista del calcio, sobre la secreción gástrica estimulada por histamina o comida ficticia.