Comparative bioavailability study of two brands of prazosin-containing tablets in healthy volunteers.
The bioavailability of two prazosin formulations was studied in 12 healthy volunteers. 1 Subject left the study. Based on the statistical tests of the pharmacokinetic parameters of prazosin in 11 volunteers, such as t 1/2, Cmax, tmax and AUC, it could be concluded that both preparations had comparable bioavailabilities.
Guelen
P J
PJ
Farma Research BV, Ravenstein, The Netherlands.
Janssen
T J
TJ
Lam
M H
MH
Vree
T B
TB
Exler
P S
PS
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D011224:Prazosin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets
D013607:Tablets; D011224:Prazosin