title: [Splenectomy in the treatment of severe generalized myasthenia gravis (first experience)].
abstract: The authors discuss the results of splenectomy carried out on 20 patients with generalized myasthenia in whom previous complex treatment including thymectomy, corticosteroid and azathioprine therapy, repeated courses of plasmapheresis during medication with anticholinesterase agents, did not cause any essential improvement. Different values of homeostasis and immunological status were studied before and in different periods after splenectomy. The condition improved in 65% of patients, which was confirmed by the results of myography; the doses of corticosteroids and anticholinesterase agents were reduced. Bearing in mind the severe condition of patients selected for splenectomy, it is recommended to treat them only in medical centers possessing sufficient experience in treatment of myasthenia. The indications and contraindications for splenectomy in complex treatment of myasthenia must be specified further.
authors: M I
authors: MI
authors: Kuzin
authors: O S
authors: OS
authors: Shkrob
authors: B M
authors: BM
authors: Gekht
authors: P S
authors: PS
authors: Vetshev
authors: D I
authors: DI
authors: Shagal
authors: O V
authors: OV
authors: Zaĭrat'iants
authors: Z Sh
authors: ZSh
authors: Khodzhaev
authors: I Kh
authors: IKh
authors: Ippolitov
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery / Q000628:therapy*; D013156:Splenectomy; D013934:Thymectomy
chemical_list: D000305:Adrenal Cortex Hormones; D002800:Cholinesterase Inhibitors
vernacular_title: Splenektomiia v lechenii tiazheloĭ generalizovannoĭ miastenii (pervyĭ opyt).