Effects of bile acids on development of pepsinogen-altered pyloric glands in rats.
The effects of dietary bile acids on the development of pepsinogenaltered pyloric glands (PAPG) were examined. Male WKY/NCrj rats were given a single dose of 160 mg/kg body wt. of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by gastric intubation and fed basal diet containing 0.3% sodium taurocholate (Na-TC), 0.3% sodium cholate (Na-C), 0.3% sodium glycocholate (Na-GC), 0.3% sodium tauroglycocholate, 0.3% sodium deoxycholate, 0.1% chenodeoxycholic acid or 0.5% lithocholic acid for 14 weeks. All rats also received 1 ml of saturated NaCl solution 4 times by i.g. intubation. At the end of week 16, the animals were killed, and the number of PAPG per cm of mucosal length was determined immunohistochemically. Na-TC, Na-C and Na-GC significantly increased the number of PAPG over the control value, suggesting that they may have activity to promote gastric carcinogenesis.
Yamaguchi
S
S
First Department of Pathology, Nagoya City University Medical School, Japan.
Tatematsu
M
M
Furihata
C
C
Takaba
K
K
Ito
N
N
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008769:Methylnitronitrosoguanidine; D010435:Pepsinogens / Q000378:metabolism / Q000494:pharmacology*; D011708:Pylorus / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000033:anatomy & histology; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000378:metabolism
D001647:Bile Acids and Salts; D010435:Pepsinogens; D008769:Methylnitronitrosoguanidine