title: [The pro-fibrotic and pro-oxidant action of isoniazid].
abstract: As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue. Two mechanisms of isoniazid's pro-fibrotic action are presented.
authors: N I
authors: NI
authors: Andrzheiuk
authors: N A
authors: NA
authors: Smirnova
authors: S E
authors: SE
authors: Narovlianskaia
authors: V P
authors: VP
authors: Novoselova
authors: E G
authors: EG
authors: Kruglova
mesh_terms: D000818:Animals; D007538:Isoniazid / Q000627:therapeutic use* / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D007538:Isoniazid
vernacular_title: Profibroticheskoe i prooksidantnoe deĭstvie izoniazida.