title: [The effect of different Yersinia pestis antigens on the cellular link in immunity].
abstract: Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y. pestis antigens (fraction I) the functional and morphological activation of thymocytes and macrophages is observed, more pronounced in C57BL/6 mice and less pronounced in CBA mice. Y. pestis antigenic preparations (fractions I and II, pesticin) act as T-cell mitogens and are thus capable of inducing the in vitro proliferation of thymocytes. At the same time the in vivo action of fraction II induces a decrease in the level of lymphocytes in the peripheral blood of mice and the destruction of lymphocytes in their thymus and spleen.
authors: I V
authors: IV
authors: Isupov
authors: L S
authors: LS
authors: Nazarova
authors: L P
authors: LP
authors: Pavlova
authors: A V
authors: AV
authors: Gor'kova
authors: E S
authors: ES
authors: Revazova
authors: V A
authors: VA
authors: Dushkin
authors: S Iu
authors: SIu
authors: Zadumina
authors: N N
authors: NN
authors: Surikov
authors: T M
authors: TM
authors: Taranenko
authors: M N
authors: MN
authors: Dzhaparidze
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000633:toxicity; D001428:Bacterial Vaccines / Q000276:immunology / Q000633:toxicity; D006239:Haplotypes / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D010586:Phagocytes / Q000276:immunology; D010930:Plague / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines
vernacular_title: Izuchenie vliianiia razlichnykh antigenov Yersinia pestis na kletochnoe zveno immuniteta.