Hepatic antipyrine metabolism in athletes.
The aim of the present study was to investigate the influence of prolonged physical exercise on hepatic metabolism. An oral antipyrine loading test (15 mg/kg body weight) was carried out on 24 healthy male subjects: 8 controls, 8 sprinters (anaerobic activity), 8 long distance runners (aerobic activity). Antipyrine clearance resulted to be significantly higher in athletes vs. controls, without a significant difference between the two groups of athletes. These results put forward the importance of the degree of physical activity (1) for the evaluation of antipyrine-loading-test results as expression of liver function and (2) whenever drugs with a low therapeutic index are used in athletes.
Orioli
S
S
Sport Medicine Unit, U.S.L., Florence, Italy.
Bandinelli
I
I
Birardi
A
A
Chieca
R
R
Buzzelli
G
G
Chiarantini
E
E
D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male
D000983:Antipyrine