title: Intracellular transport of class II MHC molecules directed by invariant chain.
abstract: Three structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endoplasmic reticulum retention signal in the full-length li suggests a role for li in the alpha-beta heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds alpha-beta dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.
authors: Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
authors: V
authors: V
authors: Lotteau
authors: L
authors: L
authors: Teyton
authors: A
authors: A
authors: Peleraux
authors: T
authors: T
authors: Nilsson
authors: L
authors: L
authors: Karlsson
authors: S L
authors: SL
authors: Schmid
authors: V
authors: V
authors: Quaranta
authors: P A
authors: PA
authors: Peterson
mesh_terms: D000911:Antibodies, Monoclonal; D001483:Base Sequence; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D015345:Oligonucleotide Probes; D015398:Signal Transduction; D014162:Transfection
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes