title: Pathology of excessive iron storage in the Afghan pika (Ochotona rufescens rufescens).
abstract: Iron deposition in the tissues of 30 Afghan pikas (Ochotona rufescens rufescens) was examined histopathologically. In all cases, iron deposits were present in the liver and in two-thirds of cases, there was portal fibrosis with tissue injury. In animals, in general, tissue injury induced by iron overload is usually mild and only in a few exceptional species does hepatic haemochromatosis occur. Thus, Afghan pikas are a rare example of reaction to iron overloading.
authors: Department of Experimental Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.
authors: H
authors: H
authors: Madarame
authors: M
authors: M
authors: Kumagai
authors: J
authors: J
authors: Suzuki
authors: A
authors: A
authors: Watanabe
authors: S
authors: S
authors: Konno
mesh_terms: D000818:Animals; D005260:Female; D007501:Iron / Q000378:metabolism*; D007793:Lagomorpha / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male
chemical_list: D007501:Iron