The effect of ivermectin on some haematological indices in rabbits: influence of vitamin K treatment.
1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, the drug reduced significantly the erythrocyte counts, haemoglobin concentration, haematocrit, mean corpuscular haemoglobin concentration and mean corpuscular haemoglobin on weeks 1, 2, 3 and 4. Platelet counts were not significantly affected. 2. In another trial, ivermectin was injected subcutaneously at a dose of 2.5 mg/kg, after pre-treatment with either saline or vitamin K (30 micrograms/kg for 30 days), and prothrombin time, bleeding time and platelet counts measured at weekly intervals for 4 weeks. Bleeding time and thrombin time were significantly increased 1 week after treatment, and remained higher than the control for 4 weeks.
Ali
B H
BH
Department of Pharmacology, Al-Arab Medical University, Benghazi, Libya.
D000818:Animals; D001760:Bleeding Time; D004906:Erythrocyte Count / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects; D007559:Ivermectin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011292:Premedication; D011817:Rabbits; D013997:Time Factors; D014812:Vitamin K / Q000097:blood / Q000494:pharmacology*
D006454:Hemoglobins; D014812:Vitamin K; D007559:Ivermectin