Total body irradiation before allogeneic and autologous bone marrow transplantation: a ten year Genoa experience.
Since 1976 in Genoa, 291 TBI treatments were performed. Before allogeneic BMT, 1000 cGy/1 fx were prescribed in the first 22 patients, and then 990 cGy/3 fx/3 d in AML and CML, and the same or 1200 cGy/6 fx/3 d in ALL. Survival (S) and probability of remaining in remission (PRR) were 54% and 69% at 80 months in 80 AML; in 62 CML 45% and 60% at 60 months; in 69 ALL, 32% and 45% at 82 months. Differences in favour of higher doses and dose rates were observed and are presented. Before autologous BMT, 1000 cGy/1 fx were prescribed to AML and NHL, and 1200 cGy/3 fx/3 d to ALL patients. Disease free survival (DFS) was 71% and 13% at 82 months in 21 AML treated in first R and 9 ALL, respectively; 81% at 32 months in 11 NHL treated in R.
Scarpati
D
D
Istituto di Radiologia, Universitá di Genova, Italy.
Corvó
R
R
Frassoni
F
F
Guenzi
M
M
Carella
A
A
Santini
G
G
Vitale
V
V
Franzone
P
P
D002985:Clinical Protocols; D003131:Combined Modality Therapy; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D008223:Lymphoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D011879:Radiotherapy Dosage; D014916:Whole-Body Irradiation / Q000379:methods