Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium.
Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 micrograms/ml) negative inotropic effect on a human in vitro atrial trabecular isometric preparation with an IC50 of 85 micrograms/ml. When atropine (22-32 micrograms/ml) was included in the atrial preparation the IC50 was shifted to greater than 120 micrograms/ml, suggesting that MEHP acts in part through the cholinergic receptors.
Barry
Y A
YA
Department of Surgery, University of Ottawa Heart Institute, Ontario, Canada.
Labow
R S
RS
Keon
W J
WJ
Tocchi
M
M
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D003864:Depression, Chemical; D004051:Diethylhexyl Phthalate / Q000633:toxicity* / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D001285:Atropine; D004051:Diethylhexyl Phthalate; C016599:mono-(2-ethylhexyl)phthalate