title: Neither age nor sex influence the expression of folate sensitive common fragile sites on human chromosomes.
abstract: The expression of folate sensitive common fragile sites was investigated in 82 normal healthy males and females of various ages. In 100 studied metaphases of each of these controls, between 0 and 56 lesions were detected (mean 18.3 +/- 10.3 SD). No significant difference was found between the mean number of expressed lesions in females and males. No age-effects were observed. Two "new" common fragile sites were discovered at 6p21 and 17q21. Their fragile site status, however, needs to be confirmed.
authors: Department of Human Genetics, University of Nijmegen, The Netherlands.
authors: D F
authors: DF
authors: Smeets
authors: G
authors: G
authors: Merkx
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D005492:Folic Acid