title: Diagnostic value of Tc-99m MAA radionuclide venography of lower extremity: as a simultaneous procedure of ventilation-perfusion scan for pulmonary embolism.
abstract: A total of 336 cases received a ventilation-perfusion(V/Q) scan for the detection of pulmonary embolism (PE). Among these, 155 cases simultaneously underwent a successful radionuclide venography study (RNV) of the lower limbs using Tc-99m macro-aggregated albumin (MAA). Concomitant pulmonary arteriography (PA) was performed in 120 cases. Fifty-four of these 120 cases successfully completed the RNV scan. There was a statistical significance in the V/Q scan for the detection of PE as confirmed by the PA (p less than 0.0001). The positive predictive value (PPV) of the RNV for PE was 75% (3/4). The negative predictive value (NPV) was 48% (24/50). The sensitivity and specificity were 10% (3/29) and 96% (24/25) for the 54 patients who had both the RNV scan and PA. For the 155 patients who had simultaneous V/Q and RNV scans, there was no statistically significant correlation between these two scans. The PPV, NPV, specificity and sensitivity were 42%(8/19), 75%(103/136), 90%(103/114) and 20%(8/41), respectively. Despite the low sensitivity and no significance of positive RNV for diagnosis of PE, RNV is still recommendable because it is a simple, non-invasive, simultaneous procedure during perfusion lung scan and has high specificity.
authors: Department of Radiology, Kaohsiung Medical College, Taiwan, Republic of China.
authors: G C
authors: GC
authors: Liu
authors: E J
authors: EJ
authors: Ferris
authors: C M
authors: CM
authors: Boyd
mesh_terms: D005268:Femoral Vein / Q000000981:diagnostic imaging*; D006801:Humans; D007866:Leg / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011859:Radiography; D011875:Radionuclide Angiography; D013668:Technetium Tc 99m Aggregated Albumin; D014692:Ventilation-Perfusion Ratio
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin