[Formation of biologically active substances during cholesterol oxidation on the surface of fluorocarbon emulsions].
Oxidative modification of cholesterol on the surface of fluorocarbon emulsions was studied. The oxidation yielded one primary product--7-peroxycholesterol. It was shown that the obtained cholesterol C7 derivatives possess a high biological activity. It was concluded that the possibility of oxidative modification of plasma substances on the surface of fluorocarbon emulsion particles with the formation of highly active compounds must be taken into account when using the fluorocarbon particles in medicine.
Berezov
A T
AT
Ivanov
A S
AS
Ivkov
V G
VG
Obraztsov
V V
VV
Khalilov
E M
EM
Archakov
A I
AI
D002784:Cholesterol / Q000031:analogs & derivatives; D002855:Chromatography, Thin Layer; D005466:Fluorocarbons / Q000627:therapeutic use; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D012397:Rosette Formation
D005466:Fluorocarbons; D002784:Cholesterol
Poiavlenie biologicheski aktivnykh veshchestv pri okislenii cholesterina na poverkhnosti ftoruglerodnykh émulsiĭ.