In vitro studies on lymphocyte Fc gamma receptor blocking factors in human renal transplantation.
In this study we have confirmed our earlier observation that the presence in pre-transplant serum of a high-molecular-weight lymphocyte Fc gamma receptor blocking factor correlates with improved human renal allograft survival. This factor was found to bind preferentially to B cells and to impair B cell function in vitro.
Sandilands
G P
GP
University Department of Pathology, Western Infirmary, Glasgow, U.K.
Highet
J
J
Degiannis
D
D
McMillan
M A
MA
Junor
B J
BJ
Briggs
J D
JD
MacSween
R N
RN
D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000378:metabolism; D001685:Biological Factors / Q000097:blood* / Q000276:immunology; D001798:Blood Proteins / Q000494:pharmacology*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D066298:In Vitro Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008934:Mitogens / Q000037:antagonists & inhibitors; D011961:Receptors, Fc / Q000378:metabolism*; D012397:Rosette Formation
D000911:Antibodies, Monoclonal; D001685:Biological Factors; D001798:Blood Proteins; D007074:Immunoglobulin G; D008934:Mitogens; D011961:Receptors, Fc