The effect of acute trichloroethylene exposure on electroretinogram components.
The effects of acute exposure to trichloroethylene (TCE) on the electroretinogram (ERG) and oscillatory potentials (OPs) were studied on adult New Zealand rabbits anesthetized with urethane. The ERG and OPs were recorded under photopic conditions with a speculum electrode, with pupils fully dilated and the cornea anesthetized. Emulsified (Intralipid) TCE was given intravenously in three consecutive injections of equal volume for a total dose varying between 24 and 85 mg/kg. Averaged ERG and OPs (50 sweeps) were taken up to 250 minutes after the last TCE injection. Our results indicated that, irrespective of the dose used, there was a significant (p less than 0.001) reduction (average: 50%) in the amplitude of the b-wave of the ERG following TCE injection. In contrast, the OPs showed a differential effect. At low doses, OP4 showed a significant (p less than 0.001) reduction resulting in some cases to its complete extinction, while at higher dose there is a marked increase in amplitude. Our results would suggest that the OPs are a better retinal potential to assess the level of TCE toxicity than is the b-wave of the ERG.
Blain
L
L
Département des Sciences Biologiques, Université de Montréal, Québec, Canada.
Lachapelle
P
P
Molotchnikoff
S
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D009498:Neurotoxins; D010775:Photic Stimulation; D011817:Rabbits; D012016:Reference Values; D012160:Retina / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014241:Trichloroethylene / Q000633:toxicity*
D009498:Neurotoxins; D014241:Trichloroethylene