[Proteus peritonitis-bacteremia in mice--a model for studying postvaccinal Proteus immunity].
The dynamics of the formation of postvaccinal immunity after immunization with preparations obtained with the use of hydroxylamine (HA) preparations from Proteus strains of different O serogroups, Salmonella minnesota Re-mutant and the common antimicrobial antigen isolated from Escherichia coli 14 has been studied on mice with Proteus peritonitis-bacteremia used as a model. The study has revealed that intraperitoneal immunization with Proteus HA preparations stimulates the phagocytic activity of peritoneal mononuclear cells in mice and induces an increase in the titers of specific O antibodies. Proteus antigens ensure the formation of anti-Proteus immunity, preventing the death of the animals from peritonitis-bacteremia. The protection of mice from such infection resulting from the injection of the common antigens of gram-negative bacteria is considerably less. These data are indicative of the possibility of using Proteus peritonitis-bacteremia as a model for the study of the protective potency of Proteus vaccines.
Zaĭtsev
E V
EV
Levina
L A
LA
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000276:immunology; D007109:Immunity; D007114:Immunization; D051379:Mice; D010538:Peritonitis / Q000276:immunology*; D011512:Proteus Infections / Q000276:immunology*; D011513:Proteus mirabilis / Q000276:immunology*; D011514:Proteus vulgaris / Q000276:immunology*; D012475:Salmonella / Q000276:immunology; D018805:Sepsis / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
Proteĭnyĭ peritonit-bakteriemiia mysheĭ--model' dlia izucheniia postvaktsinal'nogo antiproteĭnogo immuniteta.