Venostasis but not DDAVP infusion provokes the plasma fibronectin increase.
Plasma fibronectin (pFN), von Willebrand factor antigen (vWf:Ag), factor VIII procoagulant activity, fibrinogen, euglobulin lysis time (ELT) and hematocrit were determined in healthy blood donors before and after venostasis as well as after intravenous infusion of 1-deamino-8-D-arginine vasopressin (DDAVP). Both venostasis and DDAVP provoked an increase in vWf:Ag and shortening in the ELT. In contrast, venostasis only but not DDAVP induced an increase in pFN levels which was statistically significant with and without correction for a concomitant hematocrit increment. The results indicate that there is a distinct difference in the patterns of venostasis and DDAVP mediated release of proteins from the vessel wall.
Letowska
M
M
Department of Blood Storage and Preparation, Institute of Hematology, Warsaw, Poland.
Bykowska
K
K
Sablinski
J
J
Lopaciuk
S
S
Kopeć
M
M
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis / Q000097:blood*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D014111:Tourniquets
D005353:Fibronectins; D003894:Deamino Arginine Vasopressin