Association of hypercholesterolemia and apolipoprotein E4 in school children.
To investigate the association of apolipoprotein (APO) E4 and hypercholesterolemia in children, we studied the APOE phenotypes of 51 school-age children with hypercholesterolemia and of 51 age, sex and obesity index-matched controls with normocholesterolemia by two-dimensional gel electrophoresis APOE4 was present in 21 of 51 hypercholesterolemic children (41.2%), and in nine of 51 control subjects (17.6%). The difference was significant (p less than 0.01). This finding indicates that APOE4 is associated with hypercholesterolemia in children.
Yanagi
H
H
Department of Human Genetics, University of Tsukuba, Japan.
Shimakura
Y
Y
Yamanouchi
Y
Y
Watanabe
Y
Y
Tsuchiya
S
S
Hamaguchi
H
H
D000293:Adolescent; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D007564:Japan; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E