The fats of life: the importance and function of protein acylation.
Interest in the study of the direct attachment of fatty acids to cellular proteins, termed protein acylation, has been greatly stimulated by recent experimentation that has increased our understanding of the function of the attached lipid. These developments are described, and the possibility that inhibitors of protein acylation might provide new drugs is discussed.
McIlhinney
R A
RA
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, UK.
D000215:Acylation; D000818:Animals; D015195:Drug Design; D005227:Fatty Acids / Q000378:metabolism*; D050356:Lipid Metabolism; D019814:Myristic Acid; D009227:Myristic Acids / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*
D005227:Fatty Acids; D009227:Myristic Acids; D010169:Palmitic Acids; D011506:Proteins; D019814:Myristic Acid; D019308:Palmitic Acid