Increased number of chromosome aberrations in the peripheral blood culture of a retinoblastoma patient.
Chromosome studies were performed on blood lymphocytes from an eight-year-old patient whose left eye had been enucleated earlier because of retinoblastoma. GTG-banded karyotypes showed both numerical and structural chromosome aberrations, and the number of the patient's lymphocytes with chromosome aberration increased. It was concluded that retinoblastoma survivors need continuous control because of the increased risk of second primary tumors.
Selypes
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Department of Hygiene and Epidemiology, Albert Szent-Györgyi, Medical University, Szeged, Hungary.
László
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D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D005134:Eye Neoplasms / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007958:Leukocyte Count; D008214:Lymphocytes / Q000648:ultrastructure*; D012175:Retinoblastoma / Q000097:blood* / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics