Interstitial chemotherapy of experimental gliomas.
Two new approaches of interstitial (intratumoral) chemotherapy of gliomas are presented. Using s.c.-transplanted rat gliomas (G616) the therapeutic activity of biologically degradable polylactide rods as carriers for methotrexate was investigated. Carrier-mediated intratumoral chemotherapy was superior both to a systemic treatment and an intratumoral treatment with the free drug. The activity of the alkyllysophospholipids Et-18-OCH3 and BM 41.440 and of the alkylphosphocholine He-PC was investigated in a human glioma xenograft (T 406). All three compounds were highly active following intratumoral administration.
Zeller
W J
WJ
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Bauer
S
S
Remmele
T
T
Wowra
B
B
Sturm
V
V
Stricker
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D004337:Drug Carriers; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010742:Phospholipid Ethers / Q000008:administration & dosage / Q000627:therapeutic use; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D011091:Polyesters / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D004337:Drug Carriers; D010742:Phospholipid Ethers; D011091:Polyesters; D010767:Phosphorylcholine; C026659:edelfosine; C033616:poly(lactide); C039128:miltefosine; C043297:ilmofosine; D008727:Methotrexate