title: On the health status of subjects employed at factories manufacturing enzyme preparations.
abstract: Intensive exposure to the antigens of industrial strains of microorganisms and their metabolites resulted in the suppression of cellular immunity and the activation of some components of humoral immunity (IgM) and neutrophil bacterial activity in workers employed in the manufacture of enzymes. Industrial microflora (Bac. Subtilis and Asp. awamori) utilized in the technological process of microbiological synthesis of enzyme preparations was isolated from the skin in 34.25% and 16.44% and nasal and pharyngeal mucosa in 39.73% and 28.77% workers respectively. On clinical examination, most frequently affected were the skin (70.4% tested subjects), nasopharynx (64.4%), bronchopulmonary apparatus, oesophagus and GIT. Endoscopic tests confirmed the diagnoses in detecting producing strains on bronchial and oesophageal mucosa in 23.08% workers. In view of the low efficacy of employed individual protective equipment, the prevention of occupational pathology should be directed towards development or improvement of existing technological processes which would rule out intensive exposure of the human organisms to producing strains.
authors: Kiyev Research Institute of Labour Hygiene and Occupational Diseases, USSR.
authors: I L
authors: IL
authors: Savchenko
authors: A A
authors: AA
authors: Kuchuk
authors: N N
authors: NN
authors: Dmitrukha
authors: Chudnovets AYa
authors: N I
authors: NI
authors: Savchenko
authors: G V
authors: GV
authors: Prokopets
mesh_terms: D000328:Adult; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D001434:Bacteriophage Typing; D001709:Biotechnology; D004798:Enzymes / Q000096:biosynthesis; D005260:Female; D006304:Health Status; D006801:Humans; D007158:Immunologic Techniques; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016272:Occupational Health
chemical_list: D000942:Antigens, Bacterial; D004798:Enzymes