Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency.
Chloroform, monochlorodifluoromethane and nitrous oxide produced dose-related decreases in the rectal temperatures of mice allowed to choose between a warm and a cool environment. The doses used were subanaesthetic, respectively 0.0013-0.004, 0.028-0.085 and 0.25-0.5 atm. The hypothermia (up to 3.6 degrees C) was usually associated with significant reductions in time spent in the warm. The log dose-hypothermic response plots were approximately parallel and there was a marked correlation between anaesthetic potency, as measured by the abolition of the righting response, and hypothermic potency.
Pertwee
R G
RG
Department of Pharmacology, Marischal College, University of Aberdeen, Scotland.
Marshall
N R
NR
Macdonald
A G
AG
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D005617:Chlorofluorocarbons, Methane / Q000494:pharmacology; D002725:Chloroform / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009609:Nitrous Oxide / Q000494:pharmacology; D012007:Rectum
D000777:Anesthetics; D005617:Chlorofluorocarbons, Methane; C009755:fluorocarbon 22; D002725:Chloroform; D009609:Nitrous Oxide