Pradimicins M, N, O and P, new dihydrobenzo[a]naphthacenequinones produced by blocked mutants of Actinomadura hibisca P157-2.
Four blocked mutants which accumulated new dihydrobenzo[a]naphthacenequinone metabolites, designated pradimicins M, N, O and P, have been isolated from cultures of mutants of Actinomadura hibisca P157-2 resulting from treatment with N-methyl-N'-nitro-N-nitrosoguanidine. The structures of the four compounds were determined by spectral analysis. Pradimicins N, O and P contain D-alanine, while pradimicin M does not. The conformations at C-5 and C-6 of these compounds are different from those of the original pradimicins.
Sawada
Y
Y
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Tsuno
T
T
Yamamoto
H
H
Nishio
M
M
Konishi
M
M
Oki
T
T
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009154:Mutation; D009618:Nocardiaceae / Q000235:genetics / Q000378:metabolism*; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D011083:Polycyclic Compounds; C066995:pradimicin N; D000095643:Pradimicins and Benanomicins; C066994:pradimicin M; C066996:pradimicin O; C066997:pradimicin P