The etiology of multiple sclerosis: a new and extended vascular-ischemic model.
It is hypothesized that multiple sclerosis is a disease of the cerebro-vascular system. The basic defect is visualized as a wound in the CNS due to a focal hypertension of genetically susceptible vessels which results in vascular injury and the initiation of a series of biochemical and physiological events culminating in an ischemic hypoxia leading to demyelination and a secondary damaging process associated with the immune system.
Gottlieb
S F
SF
Department of Biological Sciences, University of South Alabama, Mobile 36688.
Smith
J E
JE
Neubauer
R A
RA
D002545:Brain Ischemia / Q000150:complications*; D002561:Cerebrovascular Disorders / Q000150:complications*; D006801:Humans; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000209:etiology*; D014661:Vasoconstriction / Q000502:physiology