Hypoglycemic activity of Swertia chirayita (Roxb ex Flem) Karst.
Hexane fraction of S. chirayita (250 mg/kg body wt.) induced significant fall in blood sugar and significant increase in plasma IRI simultaneously after single oral administration without influencing liver glycogen concentration in albino rats. On the other hand, daily administration for 28 days resulted in significant lowering of blood sugar and increase in plasma IRI along with a significant rise in liver glycogen. Intestinal absorption of glucose was not inhibited by hexane fraction. It is suggested that hexane fraction of S. chirayita possibly acts through its insulin releasing effect.
Chandrasekar
B
B
Central Drug Research Institute, Lucknow, India.
Bajpai
M B
MB
Mukherjee
S K
SK
D000818:Animals; D005947:Glucose / Q000493:pharmacokinetics; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007408:Intestinal Absorption / Q000187:drug effects; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D007328:Insulin; D008112:Liver Glycogen; D010936:Plant Extracts; D005947:Glucose