title: [Effects of low doses of activated protein C in experimental arterial thrombosis in rats].
abstract: Activated C protein (ACP) is a physiological anticoagulant enzyme that is capable to inactivate factors Va and VIIIa, thereby having a wide spectrum of antithrombotic effects. Low-dose ACP was tested for its ability to affect anodic current-induced arterial thrombosis in the rat. ACP given in low doses (15 micrograms/kg, 7% of total C protein in the rat) was found to produce a marked antithrombotic effect. With this, the activated partial thromboplastin time remained virtually unchanged, and its antithrombotic action was equal to that of heparin administered in a dose of 125 U/kg. In the authors' opinion, ACP may form the basis for designing a highly effective antithrombotic agent.
authors: M V
authors: MV
authors: Pyzh
authors: M D
authors: MD
authors: Smirnov
authors: D V
authors: DV
authors: Borovikov
authors: A B
authors: AB
authors: Dobrovol'skiĭ
authors: A N
authors: AN
authors: Storozhilova
authors: V L
authors: VL
authors: Golubykh
authors: N A
authors: NA
authors: Gratsianskiĭ
mesh_terms: D000818:Animals; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000008:administration & dosage*; D051381:Rats; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D011486:Protein C; D006493:Heparin
vernacular_title: Vliianie malykh doz aktivirovannogo proteina C na éksperimental'nyĭ arterial'nyĭ thromboz u krys.