Influence of phosphatidylcholine on ultrafiltration and solute transfer in CAPD patients.
Fifteen patients (mean age 59.9 +/- 16.1 years) treated by CAPD for a mean of 21.6 +/- 14 months, underwent peritoneal clearances before and after 15 days of intraperitoneal phosphatidylcholine (PC) treatment (50 mg/L). No difference was observed in urea, creatinine, uric acid, and reverse dextrose clearances. A statistically significant increase in phosphate clearances (4 and 6 hr dwell times) (1.36%) and a reduction in drainage volume (2 hr dwell time) (1.36%) were observed after treatment. Urine output and percent dextrose reabsorption were unchanged. The ultrafiltration (UF) showed a tendency to increase, which lasted for 15 days after discontinuation of treatment. This tendency allowed the patients to reduce, during the same period, the amount of hypertonic solution (23.8 L vs. 21.3 L) required. The tendency to increase UF over time deserves further study.
Querques
M
M
Division of Nephrology, Regional Hospital, Foggia, Italy.
Procaccini
D A
DA
Pappani
A
A
Strippoli
P
P
Passione
A
A
D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010710:Phosphates / Q000097:blood; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D014527:Uric Acid / Q000097:blood
D010710:Phosphates; D010713:Phosphatidylcholines; D014527:Uric Acid; D003404:Creatinine