[Synergistic effect of antioxidants and phospholipids during oxidation of natural lipids].
The effect of mixtures of phospholipids (PL) and natural antioxidants (AO)--tocopherol (TP), ubiquinone, ubichromenol, vitamin K, on the value of induction periods and on the rate of initiated oxidation of model substrates (++methyl oleate, mixtures of fatty acid methyl ethers, ethylbenzene) was studied at 60 degrees C. The possibility of synergism of different AO in the presence of PL has been established. It has been shown that the action of bioantioxidants in lipids may be increased 2.5-3.5 times. The dependences of TP and PL synergistic effect values on the concentration of the mixture components were studied. It has been shown that the synergistic++ effect grows proportionally to the amount of TP (in the interval studied up to 5 X 10(-3)M). At a constant concentration of TP the dependence of the value of induction periods increases linearly with the growth of PL concentration at the interval of 0.0-0.2%, and further it does not depend on the amount of PL. It has been shown that the synergism value does not depend on oxidation conditions and the nature of the oxidized substrate.
Burlakova
E B
EB
Storozhok
N M
NM
Khrapova
N G
NG
D000818:Animals; D000975:Antioxidants; D004041:Dietary Fats / Q000378:metabolism*; D004357:Drug Synergism; D005399:Fishes; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008954:Models, Biological; D009829:Oleic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000494:pharmacology*; D013997:Time Factors; D014451:Ubiquinone / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D004041:Dietary Fats; D009829:Oleic Acids; D010743:Phospholipids; D014451:Ubiquinone; D014810:Vitamin E; C005576:methyl oleate
Sinergicheskiĭ éffekt antioksidantov i fosfolipidov pri okislenii prirodnykh lipidov.