title: Preparation and evaluation of 99mTc-t-butylisonitrile (99mTc-TBI) for myocardial imaging: a kit for hospital radiopharmacy.
abstract: A previous method was modified to obtain [99mTc(TBI)6]+ by reacting Zn(TBI)2Br2 directly with 99mTcO4- in the presence of Sn2+ ions. [Cu(TBI)4]Cl was next used as a source of TBI. On reaction with 99mTcO4- and Sn2+ ions for 3 min at 100 degrees C, [99mTc(TBI)6]+ product of radiochemical purity greater than 90% and yield greater than 70% was obtained. Data of biodistribution in rats (2-2.5% in heart) and biokinetics in rabbits were satisfactory. The kit formulation was found to be stable and also safe for administration.
authors: Isopharm, Radiopharmaceuticals Operations, Board of Radiation and Isotope Technology, BARC Vashi Complex, New Bombay, India.
authors: S S
authors: SS
authors: Sachdev
authors: N
authors: N
authors: Ramamoorthy
authors: U N
authors: UN
authors: Nayak
authors: R B
authors: RB
authors: Patel
authors: P
authors: P
authors: Ramanathan
authors: S
authors: S
authors: Srivastava
authors: R
authors: R
authors: Lal
authors: S V
authors: SV
authors: Raghavan
authors: K B
authors: KB
authors: Shah
authors: C N
authors: CN
authors: Desai
mesh_terms: D000818:Animals; D005069:Evaluation Studies as Topic; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009570:Nitriles / Q000493:pharmacokinetics / Q000633:toxicity; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D010607:Pharmacy Service, Hospital; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D011933:Reagent Kits, Diagnostic; D014018:Tissue Distribution
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; C043714:technetium Tc 99m hexakis(tert-butylisonitrile)