[Use of monoclonal antibodies in clinical oncology].
Clinical possibilities of using monoclonal antibodies (MCA) in the immunodiagnosis of malignant neoplasms have been analysed. Certain Soviet and foreign MCA to tumor-associated antigens have been characterized, and their clinical importance has been estimated. A special attention has been paid to MCA against "cross", i.e. leukemia-associated, antigens. Basing on the data obtained it has been established that the use of even two MCA series (ICO-10 and ICO-20) makes available sufficiently accurate information on the tumor histogenesis. Besides that, MCA ICO-63, HNK-1, ICO-10, ICO-46 can be used for immunophenotyping of some solid tumors, particularly, for the immunophenotyping of human neuroblastoma cells.
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D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
Ispol'zovanie monoklonal'nykh antitel v klinicheskoĭ onkologii.