Schizophrenia and Marfan syndrome.
Five index patients and three of their first-degree relatives were affected both by schizophrenia and Marfan syndrome. Since the association appears statistically significant, the possibility of linkage disequilibrium between adjacent genes or a cytogenetic abnormality causing both disorders is suggested. These hypotheses are testable and hold promise in attempting to map the 'schizophrenia susceptibility gene' by the candidate-gene approach.
Sirota
P
P
Department of Psychiatry, Yehuda Arbarbanel Mental Health Center, Bat Yam, Israel.
Frydman
M
M
Sirota
L
L
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012803:Sick Role