Reflex co-ordination of corporal and antral contractions in the conscious dog.
This study characterizes the role of extrinsic nerves in the co-ordination of corporal and antral contractions in the dog. Fasting motor activity was recorded in conscious dogs with stomachs previously divided into separate corporal and antral pouches. Both corpus and antrum showed synchronized phases of activity and quiescence recognizable as migrating motor complexes (MMCs, duration 81.2 +/- 9.6 min, n = 4). Moreover, individual contractions were temporally linked such that corpus contractions, occurring at 76 +/- 4 s intervals, were each followed by a burst of one to three antral contractions at a frequency of 4-5 min-1. The mean latency between the onset of individual contractions in the corpus and antrum was 10.9 +/- 2.6 s (n = 4). Denervation of the antral pouch in two additional dogs did not affect the MMC cycle (mean durations 106.6 and 82.1 min) and the onset of activity in the corpus and antrum was generally co-ordinated but less precise. However, individual antral contractions were no longer linked to corporal contractions, occurring randomly throughout the corpus contraction cycle. This was associated with a lower contraction frequency in the denervated antral pouches than in the corpus (0.3 +/- 0.1 min-1 compared to 0.6 +/- 0.08 min-1). It is proposed that a vagal reflex, excited by corporal tension receptors, provides phasic excitation facilitating the generation of antral contractions. Such a reflex is likely to reinforce the myogenic mechanisms which occur in the intact stomach and thus plays a role in co-ordinating gastric peristalsis.
Rudge
L
L
Department of Biomedical Science, University of Sheffield.
Grundy
D
D
Hutson
D
D
Scratcherd
T
T
Kerrigan
D
D
D000818:Animals; D003714:Denervation; D004285:Dogs; D004594:Electrophysiology; D005215:Fasting; D005769:Gastrointestinal Motility / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D011706:Pyloric Antrum / Q000294:innervation / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D013270:Stomach / Q000294:innervation / Q000502:physiology*