[Viral retrograde-like pattern of neuronal degeneration in experimental amyotrophic leukospongiosis].
The pattern of destructive alterations of neurons and their processes at different spinal cord levels in guinea pigs with experimental amyotrophic leukospongiosis (AL) was studied by light and electron microscopy. The destruction of a portion of neurons was found to be of retrograde degeneration type. Electron microscopy of spinal conduction pathways showed that degenerative alterations occurred not only in the neuronal soma or processes but also in synaptic structures. The results indicate primary involvement of nerve cell processes, particularly axons, in experimental AL. It is suggested that AL pathogenesis is pathomorphologically based on the uptake of the agent by axonal terminals.
Votiakov
V I
VI
Erokhina
I R
IR
Arkatov
Iu M
IuM
Protas
I I
II
D000818:Animals; D001927:Brain Diseases / Q000473:pathology*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000648:ultrastructure*; D009468:Neuromuscular Diseases / Q000473:pathology*; D012183:Retrograde Degeneration; D012897:Slow Virus Diseases / Q000473:pathology*; D013116:Spinal Cord / Q000648:ultrastructure; D013997:Time Factors
O virusnom retrogradnopodobnom tipe degeneratsii neĭronov pri éksperimental'nom amiotroficheskom leĭkospongioze.