Prolonged preservation of cadaver heart with Belzer UW solution: 24-hour storage system for asphyxiated canine hearts.
The efficacy of Belzer UW solution was compared to Collins' solution in the preservation of asphyxiated cadaver hearts in a canine model. Donor hearts were stored for 24 h: 2 h of in situ hypothermic (15 degrees C) coronary perfusion plus 22 h of simple immersion in ice-cold solution. Verapamil, propranolol and prostacyclin were used for myocytoprotection in both groups. After orthotopic transplantation, all animals were weaned off bypass without inotropic support. After 1 h, however, the cardiac output was significantly higher in the Belzer UW solution group (128 +/- 28 vs. 67 +/- 13 ml/kg/min, p less than 0.01).
Shirakura
R
R
First Department of Surgery, Osaka University Medical School, Japan.
Matsuda
H
H
Nakata
S
S
Kaneko
M
M
Kawaguchi
A
A
Miyagawa
S
S
Fukushima
N
N
Kitagawa
S
S
Naka
Y
Y
Kawashima
Y
Y
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D001237:Asphyxia; D002102:Cadaver; D004285:Dogs; D005978:Glutathione; D006321:Heart; D016027:Heart Transplantation; D007328:Insulin; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011184:Postoperative Period; D011887:Raffinose; D012996:Solutions; D013997:Time Factors
D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose