title: Solitary sclerotic fibroma.
abstract: A 63-year-old Chinese man with a solitary sclerotic fibroma on the abdomen is described. Skin biopsy showed a well-demarcated dermal nodule composed of hypocellular, eosinophilic collagen bundles separated by prominent clefts. Retrospective electron microscopic study revealed wide collagen bundles containing tightly packed collagen fibrils, only 50 nm in diameter. There were no signs of Cowden's disease. To our knowledge, this is the first report of electron microscopic study of sclerotic fibroma. A brief review of the literature is included.
authors: Department of Dermatology, National Yang-Ming Medical College, Taiwan, R.O.C.
authors: W L
authors: WL
authors: Lo
authors: C K
authors: CK
authors: Wong
mesh_terms: D003094:Collagen / Q000648:ultrastructure; D005350:Fibroma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012598:Sclerosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D003094:Collagen