[Effects of adaptation to exposure to short-term stress on indices of resistance of energy metabolism and contractile function of the myocardium to acute hypoxic hypoxia and reoxygenation].
Effect of preliminary adaptation to immobilization stress with progressive duration from 15 min. to 1 h (every second day, 8 sessions) on the resistance of indices of myocardial energy metabolism and contractile function to acute hypoxic hypoxia and subsequent reoxygenation was studied. It was shown, that adaptation to short-term stress exposure by some way provided the retention of activities of important enzymes like creatine-phosphokinase and phosphorylase under the harmful action of acute hypoxia and subsequent reoxygenation. At the same time, the ATP restoration and the CP super-restoration were observed during reoxygenation. This effect, in its turn, was accompanied by a more pronounced super-restoration of the heart contractile function than in control.
Kopylov
O N
ON
Golubeva
L Iu
LIu
Saltykova
V A
VA
Meerson
F Z
FZ
D000208:Acute Disease; D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D007103:Immobilization; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D000255:Adenosine Triphosphate; D003402:Creatine Kinase
Vliianie adaptatsii k kratkovremennym stressornym vozdeĭstviiam na ustoĭchivost' pokazateleĭ énergeticheskogo metabolizma i sokratitel'noĭ funktsii miokarda k ostroĭ gipoksicheskoĭ gipoksii i reoksigenatsii.