[Rapid evaluation of the effectiveness of antibacterial drugs in experimental tularemia].
Rapid estimation of the protective effect of antibacterial drugs on Fransiella tularensis for not more than 2 days was shown possible in experiments on albino mice infected with tularemia. High efficacy of aminoglycosides (kanamycin, gentamicin, streptomycin, amikacin, netilmicin, tobramycin, sagamycin, ribostamycin and sisomicin), tetracyclines (tetracycline, doxycycline, minocycline and methacycline), rifampicin, phosphomycin and oxolinic acid was determined with the recommended rapid method. Amoxycillin, ampicillin, piperacillin, carbenicillin, erythromycin, levomycetin, cefradine, cefmetazole, cefatrizine, cefoxitin, cefsulodin and bactrim (biseptol) proved to be inefficient against the tularemia causative agent.
Oborin
V A
VA
Vasil'ev
N T
NT
Vasil'ev
P G
PG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D051379:Mice; D013997:Time Factors; D014406:Tularemia / Q000188:drug therapy* / Q000401:mortality
D000900:Anti-Bacterial Agents
Uskorennaia otsenka éffektivnosti antibakterial'nykh preparatov pri éksperimental'noĭ tuliaremii.