[Incidence of HBs-antigen in diabetics. III. Results of examination after 5 years].
By examination of a group of 617 diabetics treated by oral antidiabetics (PAD) and 263 treated with insulin for HBs-antigen carriership (HBsAg) by counter immunoelectrophoresis (CIEP) a total of 34 HBsAg carriers were detected (3.84%). This number comprised 9 treated with PAD (1.5%) and 25 insulin-treated ones (9.5%). Only six were younger than 60 years, the remaining 28 were older. Comparison with results assembled in 1984 revealed that in both groups during the five-year interval a marked decline of the prevalence of carriership had occurred--in the PAD treated group from 4.9% to 1.5% and in the insulin treated group from 29.1% to 9.5%. The decline is above all due to the high mortality of diabetics who are HBsAg carriers. In the course of five years a total of 50% died. Formerly positive patients were, if CIEP was negative, examined also by the ELISA method. On examination by both methods 13 were negative (19.7%). Of the newly detected 14 carriers 7 suffered from cirrhosis of the liver, incl. five where examination of HBsAg revealed the disease. In eight patients the carriership was confirmed only by examination by the ELISA method. Of the latter five had previously alternately positive and negative results when examined by CIEP which indicates variations of the serum concentration of the antigen.
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Interní oddĕlení nemocnice s poliklinikou, Kadan.
D000368:Aged; D002353:Carrier State / Q000175:diagnosis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000382:microbiology*; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008875:Middle Aged
D006514:Hepatitis B Surface Antigens
Výskyt HBs-antigenu u diabetiků. III. Výsledky vysetrení po 5 letech.