[Temporal dynamics of forced swimming in rats as an adequate criterion for assessing the specific effects of antidepressants].
Rats with different rhythmical structure of forced swimming had different susceptibility to antidepressant drugs. The drugs equally changed only the rhythmical index of depression but not other swimming parameters in sensible animals. As suggested, the assessment of swimming time-course can be used for antidepressant screening and preliminary selection of drug-resistant animals.
Arushanian
E B
EB
Shchetinin
E V
EV
Baturin
V A
VA
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002909:Chronobiology Phenomena / Q000187:drug effects; D003863:Depression / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D012149:Restraint, Physical; D013550:Swimming; D013997:Time Factors
D000928:Antidepressive Agents
Vremennáia dinamika prinuditel'nogo plavaniia krys kak adekvatnyĭ kriteriĭ otsenki spetsificheskoĭ aktivnosti antidepressantov.