Serial cytogenetic studies showing persistence of original clone in Hodgkin's disease.
A case of Hodgkin's disease is described in which cytogenetic studies were performed at intervals for 5 years. Clonally related chromosomally rearranged cells persisted during that time, with emergence of more complex karyotypes in the terminal phase of the disease. The chromosome findings are discussed in relation to the limited data available on banded karyotypes in Hodgkin's disease.
Reeves
B R
BR
Institute of Cancer Research, Chester Beatty Laboratories, London, England.
Nash
R
R
Lawler
S D
SD
Fisher
C
C
Treleaven
J G
JG
Wiltshaw
E
E
D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002885:Chromosomes, Human, Pair 16; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D002896:Chromosomes, Human, Pair 6; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged