[Optimization of protective properties of interferons in human cells exposed to mutagens estimated by the DNA repair activity].
Protective properties of human interferons against physical and chemical mutagens have been described earlier. This work was aimed at detecting an optimum of protective action of interferons in human fibroblasts using two criteria: the number of single-strand DNA breaks formed and the index of DNA repair synthesis. The protective ability of interferon was shown to be expressed starting after 4 h of cells' pretreatment and proceeding through 40 h in experiments with N-methyl-N-nitro-N-nitrosoquanidin. The phenomenon of stimulation of DNA repair synthesis in human cells pretreated with interferon proceeded even after replating cells during 8 h in the experiments with UV irradiation.
Gubitskaia
E G
EG
Sinel'shchikova
T A
TA
Akhmatullina
N B
NB
Zasukhina
G D
GD
D002478:Cells, Cultured; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects; D005347:Fibroblasts; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009153:Mutagens; D014466:Ultraviolet Rays
D004277:DNA, Single-Stranded; D007370:Interferon Type I; D009153:Mutagens
Optimizatsiia zashchitnykh svoĭstv interferonov v kletkakh cheloveka pri vozdeĭstvii mutagenami po kriteriiam otsenki reparativnoĭ aktivnosti DNK.