title: Antifertility efficacy of the plant Striga lutea (Scrophulariacae) on rats.
abstract: Acacetin and luteolin, the flavones isolated from the whole plant S. lutea, have been investigated for endocrine and contraceptive properties in the pre-implantation stage of pregnancy. Graded doses of these compounds, in gum acacia suspension, by oral administration from day 1 to day 4 of pregnancy showed dose-dependent anti-implantation activity (5-25 mg/kg body weight/day). MED100 was found to be 25 mg/kg body weight in the day 1-4 regimen in rats for both the compounds. In another study, a single oral dose of these compounds (10 mg/kg body weight) on day 1, 2 or 3 of pregnancy prevented 100% implantation. The compounds exhibited estrogenic property at their contraceptive dose level but failed to show antiestrogenic activity.
authors: Department of Chemistry, Gulbarga University, India.
authors: S P
authors: SP
authors: Hiremath
authors: S H
authors: SH
authors: Rao
mesh_terms: D000818:Animals; D003270:Contraceptive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004958:Estradiol / Q000378:metabolism; D005260:Female; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology; D047311:Luteolin; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003270:Contraceptive Agents; D047309:Flavones; D005419:Flavonoids; D010936:Plant Extracts; D004958:Estradiol; D047311:Luteolin; C023717:acacetin