Cerebrovascular reactivities to N-methylated catecholamines in humans, monkeys and dogs.
A comparison was made of the cerebrovascular responses of humans, monkeys and dogs to noradrenaline (NAd) and dopamine (DA) as well as to their N-methylated derivatives, adrenaline (Ad) and N-methyl dopamine (methyl DA). The present experiments demonstrated that N-methylation of both NAd and DA enhanced the contractile responses of these agents in human cerebral arteries, while only N-methylation of DA enhanced the contraction of monkey cerebral arteries, and such an enhancement was not seen in dog cerebral arteries.
Usui
H
H
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
Shirahase
H
H
Kurahashi
K
K
D000328:Adult; D000368:Aged; D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects*; D003846:Deoxyepinephrine / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008251:Macaca; D008297:Male; D008745:Methylation; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology*
D003846:Deoxyepinephrine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine