The binding of radioiodinated thrombin to rat promegakaryoblasts.
Rat promegakaryoblasts have recently been shown to possess a number of properties of mature platelets. We have studied the binding of 125I-thrombin to these cells grown in culture. The binding was found to be saturable, specific, reversible, and of high affinity. Such cell lines may be useful models for the study of platelet-agonist interactions.
Karp
G I
GI
Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
Pinnamenneni
G
G
D000818:Animals; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008533:Megakaryocytes / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013696:Temperature; D013917:Thrombin / Q000378:metabolism* / Q000494:pharmacology
D007457:Iodine Radioisotopes; D013917:Thrombin