title: Brainstem auditory evoked response and subcortical abnormalities in autism.
abstract: Previous studies of the neurobiology of autism that have used the brainstem auditory evoked response have given contradictory results. The authors of this study considered two supplementary aspects; they added an ipsilateral masking procedure, and they compared the results for every subject to the values (corrected for age and sex) of a large number of normal children. Twenty autistic (according to DSM-III-R criteria) and 13 mentally retarded (nonverbal IQ less than 75) subjects were assessed. Eighty percent of the autistic subjects had abnormal interpeak latencies, compared to 15% of the mentally retarded subjects. The I-V and III-V prolonged interpeak latency values were seen only in the autistic subjects. The ipsilateral masking procedure doubled the rate of detection of higher-brainstem abnormalities in the autistic children.
authors: Department of Psychiatry, Laval University, Quebec, Canada.
authors: J
authors: J
authors: Thivierge
authors: C
authors: C
authors: Bédard
authors: R
authors: R
authors: Côté
authors: M
authors: M
authors: Maziade
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001307:Auditory Perception / Q000502:physiology; D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology*; D001933:Brain Stem / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D010470:Perceptual Masking / Q000502:physiology; D012737:Sex Factors