Pathology of excessive iron storage in the Afghan pika (Ochotona rufescens rufescens).
Iron deposition in the tissues of 30 Afghan pikas (Ochotona rufescens rufescens) was examined histopathologically. In all cases, iron deposits were present in the liver and in two-thirds of cases, there was portal fibrosis with tissue injury. In animals, in general, tissue injury induced by iron overload is usually mild and only in a few exceptional species does hepatic haemochromatosis occur. Thus, Afghan pikas are a rare example of reaction to iron overloading.
Madarame
H
H
Department of Experimental Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.
Kumagai
M
M
Suzuki
J
J
Watanabe
A
A
Konno
S
S
D000818:Animals; D005260:Female; D007501:Iron / Q000378:metabolism*; D007793:Lagomorpha / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male
D007501:Iron