[Protective action of Salvia miltiorrhiza aqueous extract on chemically induced acute myocardial ischemia in rats].
Aqueous extract of Salvia miltiorrhiza (SM-H) can protect the acute myocardial ischemia and arrhythmia of Sprague-Dawley rats induced by isoproterenol (ISO) or BaCl2 with the following results: (1) intraperitoneal injection (i.p.) of SM-H for 3 to 5 days or intravenously (i.v.) just once significantly reduced the death rate of the animals, (2) i.v. SM-H pretreatment significantly increased the lethal dose of BaCl2 infusion, (3) i.p. SM-H significantly decreased premature ventricular contraction, ventricular fibrillation, bradycardia and mortality rate induced by bolus i.v. of BaCl2, and (4) i.p. SM-H also significantly reduced ECG J-point displacement of rats induced by ISO.
Cheng
Y Y
YY
Chinese Medicinal Material Research Centre, Chinese University of Hong Kong.
Fong
S M
SM
Chang
H M
HM
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001464:Barium; D017609:Barium Compounds; D002712:Chlorides; D003327:Coronary Disease / Q000139:chemically induced / Q000188:drug therapy*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007545:Isoproterenol; D008297:Male; D010618:Phenanthrolines / Q000627:therapeutic use*; D010936:Plant Extracts; D051381:Rats; D011919:Rats, Inbred Strains; D027561:Salvia miltiorrhiza
D017609:Barium Compounds; D002712:Chlorides; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; C024986:barium chloride; C028972:dan-shen root extract; D001464:Barium; D007545:Isoproterenol