Disseminated Trichosporon capitatum infection in a patient with acute leukemia undergoing bone marrow transplantation.
A case of disseminated infection with Trichosporon capitatum is reported in a 23-year-old patient with acute myeloid leukemia undergoing HLA-mismatched bone marrow transplantation. He was receiving immunosuppressive therapy with cyclosporine and corticosteroids for acute graft-versus-host disease and he was severely neutropenic. While being treated with fluconazole for 28 days for an oropharyngeal candidiasis the patient developed a T. capitatum septicemia. He died despite receiving amphotericin B therapy. Autopsy revealed widespread infection with T. capitatum. The portal of entry was probably the digestive tract in this patient as T. capitatum had been first isolated in the stools.
Liu
K L
KL
Service d'Onco-Hématologie, CHU de Hautepierre, Strasbourg, France.
Herbrecht
R
R
Bergerat
J P
JP
Koenig
H
H
Waller
J
J
Oberling
F
F
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications; D000935:Antifungal Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000628:therapy*; D008297:Male; D009181:Mycoses / Q000188:drug therapy / Q000209:etiology*; D009503:Neutropenia / Q000150:complications*; D009894:Opportunistic Infections / Q000209:etiology*; D018805:Sepsis / Q000209:etiology; D014250:Trichosporon
D000935:Antifungal Agents