Dialysis and renal transplantation in children: long term and recent experience.
The outcome of 38 children with endstage renal failure who entered a dialysis and renal transplant programme over a period of 16 years is reported. The initial care was given in an adult programme but in 1985 this was changed to a comprehensive and specifically paediatric programme. Patient survival was 97, 86 and 80% at 1, 5 and 10 years respectively. Thirty-four of the patients spent a mean period of 19 months (range 1-160 months) on dialysis with the preferred form of dialytic therapy being continuous ambulatory peritoneal dialysis. Primary cadaveric graft survival was 72 and 42% at 1 and 3 years respectively; although since 1985 1 year graft survival has risen to 90%. The major long term problems have been growth failure and poor social development. Eighty-seven per cent of children have been able to continue normal schooling, and of the 18 who have left school 14 (78%) are employed or undertaking tertiary education. Thus dialysis and transplantation has allowed not only excellent patient survival but also the achievement of satisfactory educational standards and subsequent employment for the majority of patients.
Lewis
D J
DJ
Victorian Paediatric Dialysis and Transplant Unit, Monash Medical Centre, Clayton, Victoria, Australia.
McIver
M
M
Scott
D F
DF
Thomson
N M
NM
D000293:Adolescent; D001379:Azathioprine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy*; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D010043:Outcome and Process Assessment, Health Care; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011239:Prednisolone / Q000008:administration & dosage; D006435:Renal Dialysis
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine