Immunogenicity of yeast-derived hepatitis B vaccine in Pakistani adults.
A study of the immunogenicity and safety of 20 micrograms recombinant DNA yeast derived hepatitis B vaccine was conducted in 153 Pakistani adults. All participants were in good physical condition, had negative hepatitis B serological markers (HBsAg, anti-HBs, anti-HBc) and normal ALT. Anti-HBs developed in 33%, 81% and 98% of subjects one month after the first, second and third dose respectively. Minor systemic and local side-effects were observed in 39% of individuals. We conclude that yeast derived hepatitis B vaccine is safe, effective and immunogenic in Pakistani adults.
Zuberi
S J
SJ
Pakistan Medical Research Council, Research Centre, Jinnah Postgraduate Medical Centre, Karachi.
Lodi
T Z
TZ
Hassan
R
R
Alam
S E
SE
D000293:Adolescent; D000328:Adult; D004274:DNA, Recombinant; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000276:immunology*; D015003:Yeasts / Q000276:immunology
D004274:DNA, Recombinant; D006510:Hepatitis B Antibodies; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines