Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice.
To explore the role of interleukins in development of arthritis, we induced collagen-induced arthritis in mice and examined interleukin activities in the inflamed joints. Arthritis developed in 90% of mice 4-5 weeks after primary immunization with type II collagen. Joint extracts from mice with collagen-induced arthritis contained high levels of interleukin 1 (IL-1)-like activity but not interleukin 2 (IL-2) or interleukin 4 (IL-4) activity. IL-1-like activities in the lesions were correlated with development of arthritis assessed by joint swelling and erythema. These results suggest that IL-1-like factor(s) may participate in the etiopathogenesis of collagen-induced arthritis in mice.
Kasama
T
T
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Kobayashi
K
K
Kanemitsu
H
H
Nakatani
K
K
Kaga
S
S
Yamagata
N
N
Negishi
M
M
Ide
H
H
Takahashi
T
T
Niwa
Y
Y
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000276:immunology*; D003094:Collagen; D004195:Disease Models, Animal; D006614:Hindlimb / Q000276:immunology; D007114:Immunization; D007375:Interleukin-1 / Q000096:biosynthesis / Q000502:physiology*; D007596:Joints / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA
D007375:Interleukin-1; D003094:Collagen