Clinical experience with a multi-element ultrasonic hyperthermia system: analysis of treatment temperatures.
A summary of tumour temperature data obtained from 31 patients who underwent 147 hyperthermia treatments with the Sonotherm 1000 ultrasonic system is presented. The treatment goal was to achieve a minimum of 42.0 degrees C in tumour for 60 min duration with normal tissues remaining below 43.0 degrees C. In 83% of treatments at least one measured tumour temperature reached or exceeded 42.0 degrees C at some time during the treatment. Nineteen per cent of these treatments had a time- and spatial-averaged temperature (measured in tumour) greater than or equal to 42.0 degrees C. A variety of anatomical sites were treated and these were grouped into four categories: groin/trunk, axilla, breast/chest wall and head/neck. Measured temperatures in tumours located in the groin and trunk sites were significantly higher (22% greater than or equal to 42 degrees C) than other locations. The head and neck treatment temperatures were significantly lower (8% of measured points greater than or equal to 42 degrees C.
Samulski
T V
TV
Duke University Medical Center, Durham, NC 27710.
Grant
W J
WJ
Oleson
J R
JR
Leopold
K A
KA
Dewhirst
M W
MW
Vallario
P
P
Blivin
J
J
D001831:Body Temperature; D005069:Evaluation Studies as Topic; D006801:Humans; D006979:Hyperthermia, Induced; D009369:Neoplasms / Q000628:therapy*; D013821:Thermometers; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*