title: [Syndrome of multiple organ failure].
abstract: The multiple organ failure syndrome (MOF) is a relatively new entity defined as the successive occurrence of respiratory (ARDS), hepatic, renal, myocardial, gastro-intestinal or neurological failure in patients with hyperkinetic haemodynamic and hypermetabolic states. The etiologies are: infection, septic and non-septic shock, burns and multiple injuries. The MOF syndrome is considered to be a generalised "inflammatory reaction" to tissue aggression involving a cascade of mediatory factors (TNF, interleukines...) of macrophagic, lymphocytic origin, causing multiple organ failure. The treatment depends on early correction of cellular hypoxia related to circulatory disturbances, nutritional support, anti-infective therapy and, in the near future, "control of mediator activity" (immunotherapy).
authors: Service de réanimation médicale, CHU Côte de Nacre, Caen.
authors: P
authors: P
authors: Charbonneau
authors: A
authors: A
authors: Suisse
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015777:Eicosanoids / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D010101:Oxygen Consumption; D010972:Platelet Activating Factor / Q000502:physiology; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D015777:Eicosanoids; D007375:Interleukin-1; D010972:Platelet Activating Factor; D014409:Tumor Necrosis Factor-alpha
vernacular_title: Le syndrome de défaillance multiviscérale.