Three years experience with local hydrocortisone treatment in women with immunological cause of infertility.
Two high selected groups of infertile women with proved cervical spermagglutinating antibodies by ficin, sucrose gradient ultracentrifugation, ELISA and microagglutinating test, by indirect MAR-test had been chosen for local hydrocortisone treatment. In the first group being composed of 20 infertile women we registered 16 decreasing or total disappearance of antisperm activity in cervical ovulatory mucus. Ten of them delivered healthy child. New 27 selected patients have treated in their immunological failure of reproduction by local hydrocortisone application, too, two of them are pregnant now. During the local hydrocortisone immunosuppression no side effects were registered. Hydrocortisone treatment seems to be a very perspective method in regulation of cervical immunological cause of infertility.
Ulcová-Gallová
Z
Z
Department of Obstetrics and Gynecology, Charles University, Pilsen.
Mráz
L
L
Plánicková
E
E
Macků
F
F
Ulc
I
I
D000328:Adult; D000906:Antibodies / Q000032:analysis; D002582:Cervix Mucus / Q000276:immunology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007247:Infertility, Female / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D010570:Pessaries; D011247:Pregnancy; D013073:Sperm Agglutination / Q000187:drug effects* / Q000276:immunology; D013084:Sperm-Ovum Interactions / Q000187:drug effects; D013094:Spermatozoa / Q000276:immunology*
D000906:Antibodies; D006854:Hydrocortisone