title: A phase II study of idarubicin and prednisone in multiple myeloma.
abstract: Twenty-one patients with multiple myeloma were treated with idarubicin 45 mg/m2 orally day 1 and prednisone 60 mg/m2 day 1-4 every three weeks. Moderate to severe gastrointestinal and hematopoietic toxicity were observed. Twelve of the twenty-one patients had relapsed on prior treatment. Of these, 2 patients responded. Two patients had primary resistant disease, neither responded. Seven patients had received no prior treatment, three responded. Idarubicin and prednisone have modest activity in refractory myeloma, with short duration of response and severe toxicity.
authors: Department of Medical Oncology, University of Pretoria, Rep. of South Africa.
authors: A S
authors: AS
authors: Alberts
authors: G
authors: G
authors: Falkson
authors: B L
authors: BL
authors: Rapoport
authors: A
authors: A
authors: Uys
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000401:mortality; D011241:Prednisone / Q000008:administration & dosage* / Q000009:adverse effects; D015996:Survival Rate
chemical_list: D011241:Prednisone; D015255:Idarubicin