[Sensitivity of tumor cells to cytostatic action of NK cells and their capacity of releasing prostaglandin E].
The studies of twelve tumor cell strains revealed the correlation between the degree of their malignancy and their capacity to secrete PGE following in vitro contact with NK cells. Actively secreting PGE tumor cells were shown to be highly resistant to CTA of NK cells. Apparently, the ability of tumor cells to secrete PGE following the contact with NK cells and inhibition of their CTA are one of the mechanisms of tumor cell defence against NK cytotoxicity.
Kliuchareva
G E
GE
Matveeva
V A
VA
Uvarova
E N
EN
D000818:Animals; D006224:Cricetinae; D007694:Killer Cells, Natural / Q000276:immunology*; D008647:Mesocricetus; D011458:Prostaglandins E / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D011458:Prostaglandins E
Chuvstvitel'nost' opukholevykh kletok k tsitostaticheskomu deĭstviiu NK-kletok i ikh sposobnost' k vybrosu prostaglandinov E-tipa.