Preliminary X-ray analysis of crystals of fasciculin 1, a potent acetylcholinesterase inhibitor from green mamba venom.
Fasciculin 1 from Dendroaspis angusticeps has been crystallized by vapour diffusion, in sodium acetate using sodium thiocyanate as precipitant. Tetragonal crystals (space group P4(1)2(1)2 or P4(3)2(1)2) diffract to 1.8 A resolution. The unit cell parameters are a = 40.4 A and c = 81.1 A. We estimated the presence of one molecule in the asymmetric unit.
Ménez
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Institut de Chimie des Substances Naturelles, CNRS 91198, Gif-sur-Yvette, France.
Ducruix
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D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D004546:Elapid Venoms / Q000737:chemistry* / Q000302:isolation & purification; D011487:Protein Conformation; D014961:X-Ray Diffraction
D002800:Cholinesterase Inhibitors; D004546:Elapid Venoms; C044937:fasciculin