title: Effects of altered dietary sodium intake on hormonal profiles in salt-sensitive hypertensive rats.
abstract: Blood pressure and selected putatively influential hormones were measured in Brattleboro rats which were without diabetes insipidus and which were subjected to various manipulations in dietary sodium intake. Rats fed a control diet from weaning to 16 weeks of age showed a slow increase in blood pressure whereas rats fed a sodium-enriched diet for the same period exhibited sustained hypertension (115 +/- 3 versus 169 +/- 5 (S.E.M.) mmHg). In animals fed a sodium-enriched diet plasma concentrations of antidiuretic hormone (ADH) were significantly increased from 55 +/- 8 to 108 +/- 5 fmol/l. Rats fed the control diet from weaning (group A) and subsequently maintained on that diet or changed to a sodium-enriched diet or sodium-deficient diet showed no differences in their blood pressure. Plasma hormone concentrations were similar in these groups, with the exception of aldosterone suppression in rats switched from control to a sodium-enriched diet (0.26 +/- 0.04 versus 0.08 +/- 0.03 nmol/l; P less than 0.001). Animals fed the sodium-enriched diet from weaning to 16 weeks of age (group b) and either maintained on that diet or changed to a control diet showed little change in their established hypertension. Transfer to the control diet was associated with increased plasma renin concentrations (PRC) (13.8 +/- 2.1 to 122.6 +/- 6.2 nmol/l) and plasma aldosterone concentrations (0.04 +/- 0.01 to 0.08 +/- 0.01 nmol/l; P less than 0.001) but corticosteroids and ADH concentrations were unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Animal and Plant Sciences, University of Sheffield.
authors: N
authors: N
authors: Hazon
authors: I W
authors: IW
authors: Henderson
mesh_terms: D000450:Aldosterone / Q000097:blood; D000818:Animals; D003348:Cortisone / Q000097:blood; D003900:Desoxycorticosterone / Q000031:analogs & derivatives / Q000097:blood; D004032:Diet; D006889:Hydroxycorticosteroids / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D051381:Rats; D011910:Rats, Brattleboro; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D012982:Sodium, Dietary / Q000008:administration & dosage*; D014667:Vasopressins / Q000097:blood*
chemical_list: D006889:Hydroxycorticosteroids; D012982:Sodium, Dietary; D014667:Vasopressins; C042509:18-hydroxydeoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D012083:Renin; D003348:Cortisone