Effects of ranitidine and metoclopramide on gastric fluid pH and volume in children.
To determine the effects of ranitidine and metoclopramide on gastric fluid in children, 40 healthy children (aged 2-8 yr) were allocated randomly to groups of 10 to receive one of four oral premedications 4 h before surgery: no premedication, metoclopramide 0.1 mg kg-1, ranitidine 2 mg kg-1 and metoclopramide 0.1 mg kg-1 with ranitidine 2 mg kg-1. After tracheal intubation, gastric fluid was aspirated and analysed for pH and total fluid volume. Ranitidine, with or without metoclopramide, increased gastric fluid pH significantly compared with control (P less than 0.05). Gastric fluid volume did not change significantly.
Christensen
S
S
Department of Anaesthesia, Hospital for Sick Children, Toronto, Ontario, Canada.
Farrow-Gillespie
A
A
Lerman
J
J
D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008787:Metoclopramide / Q000494:pharmacology*; D011229:Preanesthetic Medication; D011899:Ranitidine / Q000494:pharmacology*
D011899:Ranitidine; D008787:Metoclopramide