title: Effect of calcium entry blocker nitrendipine on renal function after renal vascular occlusion.
abstract: The ability of the Ca entry blocker nitrendipine to improve postischemic renal function was studied in nine groups (n = 70) of rats. After anesthesia, nitrendipine was administered for 15 min through the femoral vein. The dose administered depended on the group. Group 1 (n = 7), the control, received only 0.9% NaCl, group 2 (n = 12) 0.25 mg/kg; group 3 (n = 10) 0.50 mg/kg; group 4 (n = 8) 0.75 mg/kg; group 5 (n = 6) 1.00 mg/kg; group 6 (n = 7) 1.50 mg/kg; group 7 (n = 7) 2.00 mg/kg; group 8 (n = 6) 2.50 mg/kg; and group 9 (n = 7) 3.00 mg/kg. After the administration of nitrendipine, the kidneys were rendered ischemic for one hour by cross-clamping the renal vessels. Comparison of 24-h creatinine clearances for 72 h after reversal of ischemia demonstrated that nitrendipine was capable of providing a degree of protection against renal ischemia and the protective effect was dose dependent (p less than .05).
authors: Department of Anesthesiology/Critical Care Medicine, Loma Linda University School of Medicine, CA 92354.
authors: W K
authors: WK
authors: Jacobsen
authors: D J
authors: DJ
authors: Cole
authors: S C
authors: SC
authors: Stewart
authors: R D
authors: RD
authors: Martin
authors: B L
authors: BL
authors: Fandrich
authors: R E
authors: RE
authors: Hertzog
authors: B A
authors: BA
authors: Briggs
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D000818:Animals; D003404:Creatinine / Q000652:urine; D004305:Dose-Response Relationship, Drug; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012078:Renal Artery Obstruction / Q000150:complications*
chemical_list: D009568:Nitrendipine; D003404:Creatinine