Severe intravascular haemolysis in a renal transplant recipient due to anti-B of donor origin.
A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.
Orchard
J
J
Blood Bank, Cardiff Royal Infirmary, UK.
Young
N T
NT
Smith
C
C
Thomas
S
S
Darke
C
C
D000017:ABO Blood-Group System / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D003298:Coombs Test; D006461:Hemolysis; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction
D000017:ABO Blood-Group System; D000906:Antibodies