title: Antibiotics from basidiomycetes. XXXVII. New inhibitors of cholesterol biosynthesis from cultures of Xerula melanotricha Dörfelt.
abstract: Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of 14C- acetate into cholesterol in HeLa cells while the incorporation of 14C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.
authors: Lehrbereich Biotechnologie der Universität, Kaiserslautern, FRG.
authors: D
authors: D
authors: Kuhnt
authors: T
authors: T
authors: Anke
authors: H
authors: H
authors: Besl
authors: M
authors: M
authors: Bross
authors: R
authors: R
authors: Herrmann
authors: U
authors: U
authors: Mocek
authors: B
authors: B
authors: Steffan
authors: W
authors: W
authors: Steglich
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D053280:Diynes; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D053280:Diynes; D007783:Lactones; C066798:dihydroxerulin; C066799:xerulin; C066800:xerulinic acid