[Comparison between the therapeutic effects of ginseng-aconitum-bupleurum injection and dexamethasone on septic shock complicated with disseminated intravascular coagulation induced by E. coli in dogs].
In this paper, the authors report the therapeutic effects of Ginseng-Aconitum-Bupleurum (GAB) injection on septic shock complicated with DIC induced by intravenous injection of live E. Coli in dogs. The experimental results indicated that the survival rate at 48 h after intravenous injection of live E. Coli was 30% in saline group, 80% in GAB, 90% in dexamethasone (Dex) group. The BPC, WBC, FG, AT-III, beta-GC, PHb were 82 +/- 28, 9.1 +/- 5.9, 1.85 +/- 0.41, 112 +/- 43, 0.37 +/- 0.17, 0.11 +/- 0.07 respectively for GAB, 70 +/- 37, 6.7 +/- 3.7, 1.55 +/- 0.36, 59 +/- 29, 0.91 +/- 0.28, 0.12 +/- 0.06 respectively for the saline group, 58 +/- 33, 6.3 +/- 2.9, 1.95 +/- 0.21, 103 +/- 43, 0.50 +/- 0.16, 0.13 +/- 0.06 respectively for Dex. The BPC, WBC, FG, AT-III levels of the GAB group were significantly higher than those in saline group and were not significantly difference from the Dex group. The beta-GC and PHb levels of the GAB group were significantly reductive than the saline group and were not significantly different from the Dex group. The results showed that the survival rate was higher, the DIC was inhibited and normal biomembranes were maintained in the GAB group.
Liu
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Central Laboratory, Hunan College of TCM, Changsha.
D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D005894:Panax; D010946:Plants, Medicinal; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D003907:Dexamethasone