Chromosomal changes in thyroid tumors. Relation with DNA content, karyotypic features, and clinical data.
A cytogenetic study was performed in 63 thyroid tumors after a monolayer short-term culture. Clonal chromosomal changes were found in 47% of carcinomas and 31% of adenomas. Chromosome 7 was altered in 40% of cytogenetically abnormal tumors. The modal DNA index measured in 26 tumors was consistent with the chromosomal mode in 88% of cases. A quantitative morphometric analysis of nuclear features differentiated between diploid thyroid adenomas with or without a single translocation, which suggests that they have different biological properties. Clonal chromosomal changes were observed in 78% of carcinomas with an aggressive behavior, but only 28% of those had no risk factors. The two patients who died early had abnormalities of chromosome 7.
Teyssier
J R
JR
Laboratories of Histology-Embryology-Cytogenetics (INSERM U314), Reims, France.
Liautaud-Roger
F
F
Ferre
D
D
Patey
M
M
Dufer
J
J
D000236:Adenoma / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm