title: Sodium bromide treatment influences the plasticity of somatosensory responses in the rat cortex as induced by enucleation.
abstract: Effects of sodium bromide were studied on central neuroplasticity induced by early binocular enucleation. It has previously been found that enucleation on the day of birth, but not later than the first postnatal week, resulted in changes in the occipital cortex, such as the invasion of somatosensory evoked activity into the visual cortex areas. The present results showed that sodium bromide treatment extended at least up to 15 days after birth, the critical period during which somatosensory projections could be modified by visual deafferentation. Together with observations of Frost [J. comp. Neurol. (1981) 203, 227-256; Devl Brain Res. (1982) 3, 627-636], the present results suggest a mutual dependency of visual and somatosensory projection development. The present study is the first demonstration that the critical period of development, during which a specific type of neural plasticity can be induced, may be prolonged by pharmacological means, i.e. by chronic treatment with sodium bromide.
authors: Department of Anatomy, University of Goettingen, F.R.G.
authors: J
authors: J
authors: Toldi
authors: O
authors: O
authors: Feher
authors: F
authors: F
authors: Joo
authors: A
authors: A
authors: Antal
authors: J R
authors: JR
authors: Wolff
mesh_terms: D000818:Animals; D001965:Bromides / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000502:physiology; D004327:Drinking Behavior / Q000502:physiology; D004558:Electric Stimulation; D004597:Electroshock; D015353:Eye Enucleation / Q000009:adverse effects*; D005260:Female; D008297:Male; D009778:Occipital Lobe / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*; D017670:Sodium Compounds; D013003:Somatosensory Cortex / Q000033:anatomy & histology* / Q000187:drug effects; D013238:Stereotaxic Techniques; D014732:Vibration
chemical_list: D001965:Bromides; D017670:Sodium Compounds; D012964:Sodium; C027938:sodium bromide