Clinical and physical aspects of total body irradiation for bone marrow transplantation in Nijmegen.
Eighty-nine patients were transplanted with allogeneic bone marrow after a standard conditioning regimen consisting of cyclophosphamide and fractionated total body irradiation (2 x 4.5 Gy) with average dose rates of 4.1 and 12.3 cGy/min, respectively. The average rectum and lung dose was 9.2 +/- 0.45 and 7.5 +/- 0.78 Gy. In vivo dosimetry was performed in 71 patients irradiated with 18 MV X-rays from left and right lateral. Forty-three patients (48%) died. After increasing the dose rate the incidence of interstitial pneumonitis increased, but the number of relapses decreased.
Hoogenhout
J
J
Department of Radiotherapy, St. Radboud University Hospital, Nijmegen, The Netherlands.
Brouwer
W F
WF
van Gasteren
J J
JJ
Schattenberg
A
A
de Witte
T
T
van Daal
W A
WA
Haanen
C A
CA
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D009426:Netherlands; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D011379:Prognosis; D011879:Radiotherapy Dosage; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*
D003520:Cyclophosphamide