title: Immediate hypersensitivity to Parthenium hysterophorus. I. Association of HLA antigens and Parthenium rhinitis.
abstract: Lymphocytes collected from rhinitis subjects with strong positive skin reactions to the pollen allergens of Parthenium hysterophorus (American feverfew) having moderate to high titres of Parthenium-specific serum IgE were analysed for association of HLA-antigens covering 13 specificities of HLA-A, 17 specificities of HLA-B and eight specificities of HLA-DR loci by the NIH two-stage microlymphocytotoxicity assay. Comparison of the phenotypic frequencies of HLA-A and B antigens between Parthenium rhinitis subjects (n = 22) and control subjects (n = 137) did not suggest any significant association when tested for these antigen specificities. A significant correlation in the association of HLA-DR3 antigen with a relative risk of 11.33, however, was observed in Parthenium rhinitis subjects (n = 30) when compared to controls (n = 50).
authors: Department of Biochemistry, Indian Institute of Science, Bangalore.
authors: P
authors: P
authors: Sriramarao
authors: B
authors: B
authors: Selvakumar
authors: C
authors: C
authors: Damodaran
authors: B S
authors: BS
authors: Rao
authors: O
authors: O
authors: Prakash
authors: P V
authors: PV
authors: Rao
mesh_terms: D003429:Cross Reactions / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D007194:India; D010944:Plants / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D012882:Skin Tests
chemical_list: D006680:HLA Antigens; D007073:Immunoglobulin E