[The effect of dexamethasone on the orientation and exploratory activity and the amino acid composition in different CNS structures of rats in experimental neurosis].
The effect of dexamethasone (50 mg/kg, intraperitoneally, 24 hours before the experiment) on the orientation activity of the rats in the "open field" was studied in experimental neurosis. The formation of neurosis was accompanied by changes in the locomotor and orientation activities, amino acid concentrations in the brain structures. This manifested itself in an increase of GABA amounts in the frontal cortex, hippocampus and striatum by 56, 29 and 27%, respectively (p less than 0.001, 0.05 and 0.001). In the subcortical structures the contents of glutamic acid increased and the amounts of phenylalanine decreased. Dexamethasone was found to enhance the orientation activity and to change the neurochemical organization of the brain structures, to a greater extent in the hippocampus, that manifested itself in a sharp decrease of the contents of neuroactive amino acids.
Nerush
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PA
D000596:Amino Acids / Q000032:analysis / Q000187:drug effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002490:Central Nervous System / Q000737:chemistry / Q000187:drug effects; D003220:Conflict, Psychological; D003907:Dexamethasone / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D009497:Neurotic Disorders / Q000378:metabolism*; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D000596:Amino Acids; D003907:Dexamethasone
Vliianie deksametazona na orientirovochno-issledovatel'skuiu aktivnost' i aminokislotnyĭ sostav v razlichnykh strukturakh TsNS krys pri éksperimental'nom nevroze.