title: Bioinequivalence of marketed diltiazem preparations.
abstract: A bioequivalence study of three brands of regular diltiazem--Angizem (A), Dilzem (B) and Herbesser (C) has been carried out in 5 healthy, male volunteers. After a single oral dose of 60 mg of each preparation, the mean AUC (0-8 h) and Cmax of preparation B was significantly higher than of brands A and C. The tmax of A and B was significantly lower than of C. B had a higher dissolution rate in vitro (98.8% dissolved in 45 min) than A and C. Thus, there was bioinequivalence of the three brands of diltiazem, due partly to differences in dissolution and perhaps in part to a first pass effect.
authors: Department of Pharmacology, Seth GS Medical College, Parel, Bombay, India.
authors: M V
authors: MV
authors: Joshi
authors: P C
authors: PC
authors: Gokhale
authors: S M
authors: SM
authors: Pohujani
authors: S S
authors: SS
authors: Dalvi
authors: S M
authors: SM
authors: Karandikar
authors: N A
authors: NA
authors: Kshirsagar
mesh_terms: D000328:Adult; D001682:Biological Availability; D004110:Diltiazem / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007194:India; D008297:Male; D012995:Solubility; D013810:Therapeutic Equivalency
chemical_list: D004110:Diltiazem