title: Effect of distension on adrenergic innervation of the rat urinary bladder.
abstract: The effect of distension on adrenergic innervation was investigated in the rat urinary bladder. Bladders were distended for 3 h by forced diuresis and balloon obstruction, and specimens were taken from the bladder dome, body and neck for the demonstration of glyoxylic acid-induced fluorescence of catecholamines. Depletion of catecholamines started after 10 h and was almost complete after 2 days. The fluorescence had recovered part way after 5-7 days and was practically normal after 21 days. Small, intensely fluorescent (SIF) cells in the ganglia continued to leak catecholamines throughout the 21-day study period. The primary clinical success of distension therapy for the treatment of unstable bladder may be at least partly due to a reversible disturbance in the function of the adrenergic nerves, which have an excitatory alpha-adrenergic dominance in such cases, but the persistent leakage from SIF cells raises the question of whether distension causes prolonged disturbances in bladder function.
authors: Department of Surgery, Oulu University Central Hospital, Finland.
authors: T
authors: T
authors: Tammela
authors: L
authors: L
authors: Lasanen
authors: T
authors: T
authors: Waris
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000032:analysis; D004232:Diuretics; D005260:Female; D006038:Glyoxylates; D008856:Microscopy, Fluorescence; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation* / Q000503:physiopathology; D016055:Urinary Retention / Q000503:physiopathology
chemical_list: D002395:Catecholamines; D004232:Diuretics; D006038:Glyoxylates; C031150:glyoxylic acid