title: Mixed connective tissue disease with arterial thrombosis, antiphospholipid antibodies and heparin induced thrombocytopenia.
abstract: We report a patient with mixed connective tissue disease (MCTD) who presented with thrombosis of the right femoral artery in association with antiphospholipid antibodies (aPL). When treated surgically and with heparin prophylaxis, she developed heparin induced thrombocytopenia and thrombosis which necessitated amputation of a lower limb. Thus our patient developed 2 separate groups of autoantibodies associated with thrombotic events. Our case highlights an association between thrombosis, aPL and MCTD. Furthermore, it emphasizes a need for intensive monitoring when hypercoaguable individuals with connective tissue disorders are treated with heparin.
authors: Dept. of Immunology/Pathology, St. James's Hospital, Dublin, Ireland.
authors: J
authors: J
authors: Jackson
authors: M
authors: M
authors: McDonald
authors: E
authors: E
authors: Casey
authors: S
authors: S
authors: Kelleher
authors: A
authors: A
authors: Murray
authors: I
authors: I
authors: Temperley
authors: G
authors: G
authors: Shanik
authors: C
authors: C
authors: Feighery
authors: F
authors: F
authors: Jackson
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D005260:Female; D005263:Femoral Artery; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D010743:Phospholipids / Q000276:immunology*; D013921:Thrombocytopenia / Q000139:chemically induced; D013927:Thrombosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology
chemical_list: D000906:Antibodies; D010743:Phospholipids; D006493:Heparin