[The morphological heterogeneity of mesangioproliferative glomerulonephritis].
Three variants of mesangioproliferative glomerulonephritis (MPGN) are distinguished on the basis of quantitative and qualitative morphological study of 172 kidney biopsies. The first variant is characterized by subendothelial and mesangial deposits of IgA and C3 in the glomeruli, the lack of fibroplastically transformed (FT) glomeruli and small tubulointerstitial component (TIC), the predominance of the phagocytizing mesangial cells; the second variant by the subendothelial deposits in the glomeruli of IgM or IgM and C3, the absence of FT glomeruli and TIC, the presence of an equal number of phagocytizing and synthetizing mesangial cells. Glomerular deposition of IgG or the absence in the glomeruli of all immunoglobulins and C3, the presence of FT glomeruli and TIC, pronounced accumulation of mesangial matrix and moderate proliferation of predominantly synthetizing and fibrosing mesangial cells are characteristic of the third variant. Recognition of the MPGN variants allows one to understand the variety of its clinical manifestations and differing prognosis.
Gasanov
A B
AB
Varshavskiĭ
V A
VA
Serov
V V
VV
D001706:Biopsy; D005920:Glomerular Mesangium / Q000378:metabolism / Q000648:ultrastructure; D015432:Glomerulonephritis, Membranoproliferative / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism / Q000648:ultrastructure; D007684:Kidney Tubules / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron
Morfologicheskaia geterogennost' mezangioproliferativnogo glomerulonefrita.