[Serum 1,25-dihydroxyvitamin D in insulin-dependent diabetes mellitus].
To evaluate the relationship between insulin and hormonal vitamin D system we compared the serum concentrations of 1.25 dihydroxyvitamin D (1.25 D) in a group of 56 patients with insulin dependent diabetes mellitus (IDDM) with those from a control population of 26 healthy individuals. We did not find overall significant differences in 1.25 D levels between diabetic patients and control individuals (32.6 +/- 12 vs 35.4 +/- 9 pg/ml), but there were differences between the different patient subgroups depending on the duration of the disease. The dose of insulin and the 1.25 D levels were linearly correlated (r = 0.3693, p = 0.0051). The patients with IDDM had normal 1.25 D levels. Exogenous insulin administration may have relevance for the interpretation of these results.
Muñoz-Torres
M
M
Unidad Metabólica, Hospital Universitario, Granada.
de Madrid
J D
JD
Escobar-Jiménez
F
F
Ortego Centeno
N
N
D000293:Adolescent; D000328:Adult; D002117:Calcitriol / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007328:Insulin; D002117:Calcitriol
1,25 dihidroxivitamina D sérica en la diabetes mellitus insulinodependiente.