Age dependency of triiodothyronine-induced thermogenesis in young chicks: inhibition by propylthiouracil.
Age dependency of triiodothyronine (T3)-induced thermogenesis of young chicks at 1 and 2 wk of age was investigated by dietary administration of .5% propylthiouracil (PTU), an inhibitor of thyroid hormone synthesis. Heat production measured by indirect calorimetry was increased by an intraperitoneal injection of T3, but the thermogenic effect was larger at 2 wk than at 1 wk of age. Heat production at 2 wk of age was decreased by PTU when the T3 was not administered, whereas the inhibitory effect of PTU was not found at 1 wk of age. It would appear, therefore, that little or no thermogenesis is responsive to exogenous T3 in young chicks at 1 wk of age even though the suppression of endogenous T3 is likely to occur by the PTU treatment.
Hwang-Bo
J
J
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
Muramatsu
T
T
Okumura
J
J
D000367:Age Factors; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D002151:Calorimetry; D002645:Chickens / Q000378:metabolism*; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology*; D014284:Triiodothyronine / Q000037:antagonists & inhibitors / Q000502:physiology*; D015430:Weight Gain
D014284:Triiodothyronine; D011441:Propylthiouracil