title: Analysis of antiepileptic drugs.
abstract: This review discussed various analytical methods for the determination of antiepileptic drugs and their metabolites in biological tissues. The emphasis was on the reports published since their last review [J. T. Burke and J. P. Thenot, J. Chromatogr., 340 (1985) 199]. Both chromatographic and immunological procedure were cited and compared. Methods for individual and simultaneous quantitation of standard antiepileptic drugs and their metabolites were considered. In addition, a discussion of free drug determination and procedures for new candidate antiepileptic drugs were included.
authors: Preclinical Pharmacology Section, NINDS, NIH, Bethesda, MD 20892.
authors: I M
authors: IM
authors: Kapetanovic
mesh_terms: D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans
chemical_list: D000927:Anticonvulsants