title: Gametocytocidal activity of the antimalarial alpha/beta arteether against Plasmodium cynomolgi B.
abstract: A new sesquiterpene lactone alpha/beta arteether (a 30:70 mixture of enantiomers), which possesses very high blood schizontocidal activity, has been evaluated for gametocytocidal/sporontocidal action against Plasmodium cynomolgi B infection in the rhesus monkey. This paper reports gametocytocidal action of this new antimalarial drug at 2.5-5 mg/kg (single im dose) against P. cynomologi B as shown by the complete absence of mosquito infectivity. No sporontocidal action was demonstrable in the vector at a dose of up to 20-50 mg/kg im.
authors: Central Drug Research Institute, Lucknow, India.
authors: R
authors: R
authors: Tripathi
authors: G P
authors: GP
authors: Dutta
authors: R A
authors: RA
authors: Vishwakarma
mesh_terms: D000818:Animals; D000852:Anopheles / Q000472:pathogenicity; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D008253:Macaca mulatta; D010270:Parasite Egg Count; D010961:Plasmodium / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013170:Spores / Q000187:drug effects*; D015053:Zygote / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055141:artemotil