A prospective comparison of rubidium-82 PET and thallium-201 SPECT myocardial perfusion imaging utilizing a single dipyridamole stress in the diagnosis of coronary artery disease.
The purpose of the present study is to prospectively compare myocardial perfusion imaging with rubidium-82 (82Rb) by positron emission tomography (PET) with thallium-201 (201Tl) imaging by single-photon emission tomography (SPECT) by recording both studies with a single dipyridamole handgrip stress, and reading both sets of images with the same display technique. In a series of 202 patients with previous coronary arteriography, the sensitivity, specificity, and accuracy of 82Rb PET were 93%, 78%, and 90% and for 201Tl SPECT 76%, 80%, and 77%, respectively. When 70 patients with previous therapeutic interventions were excluded, the remaining 132 patients showed a sensitivity, specificity, and accuracy of 95%, 82% and 92% for 82Rb PET and 79%, 76%, and 78% for 201Tl SPECT. The improved contrast resolution of PET resulted in markedly superior images and a more confident identification of defects.
Go
R T
RT
Department of Nuclear Medicine and Cardiology, Cleveland Clinic Foundation, Ohio 44195-5074.
Marwick
T H
TH
MacIntyre
W J
WJ
Saha
G B
GB
Neumann
D R
DR
Underwood
D A
DA
Simpfendorfer
C C
CC
D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D004176:Dipyridamole; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007091:Image Processing, Computer-Assisted; D011446:Prospective Studies; D012414:Rubidium Radioisotopes; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D012414:Rubidium Radioisotopes; D013794:Thallium Radioisotopes; D004176:Dipyridamole