Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses.
Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented.
Pazzaglia
U E
UE
Clinica Ortopedica, Università di Pavia, I.R.C.C.S. Policlinico San Matteo, Italy.
Pedrotti
L
L
Beluffi
G
G
Monafò
V
V
Savasta
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005096:Exostoses / Q000503:physiopathology; D005097:Exostoses, Multiple Hereditary / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011859:Radiography