Spontaneous primary astrocytoma in the spinal cord of a mouse and a rat.
A spontaneous astrocytoma was observed as an incidental finding in the thoracic spinal cord of a control Charles Rivers CD-1 female mouse from a 2 yr oncogenicity study. An astrocytoma was also observed in the lumbar spinal cord of a Charles Rivers Sprague-Dawley control, female rat from a 2 yr oncogenicity study. The mouse was clinically normal and was sacrificed at the end of the 2 yr study. The rat was killed at 512 days of age because of posterior paralysis.
Frith
C H
CH
Toxicology Pathology Associates, Little Rock, Arkansas 72211.
Chandra
M
M
D000818:Animals; D001254:Astrocytoma / Q000473:pathology / Q000662:veterinary*; D005260:Female; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000662:veterinary*