title: [Nitrates and nitrites and the utilization of beta-carotene. I. The effect of different amounts of dietary nitrates and nitrites on the utilization of beta-carotene in rats].
abstract: The subject of the study was demonstration whether and in what extent different amounts of nitrates and nitrites in the diet affect the utilization of beta-carotene by rat organism. The level of vitamin A in the liver was accepted as an indicator of this utilization in accordance with the method of combined balance studies and liver test; additionally the plasma vitamin A level was determined. Two biological experiments lasting 30 days were carried out on male Wistar rats standardized with respect to hepatic vitamin A content. The animals were given orally 30 mcg daily an oil solution of beta-carotene and diets with varying amounts of potassium nitrate (0.5; 1.0; 2.0; 4.0; 6.0%) and sodium nitrite (0.05; 0.1; 0.5; 1.0%). Nitrates and nitrites in the diets reduced the utilization of beta-carotene in a dose-dependent way. The nitrate reduced the utilization of the provitamins by from about 50% to over 60%, and the nitrite reduced it by from over 60% to about 80%. The studied compounds exerted also a negative effect on the consumption of diet and weight gain.
authors: Zakładu Oceny Zywienia Instytutu Zywienia Człowieka SGGW-AR w Warszawie.
authors: D
authors: D
authors: Majchrzak
authors: A
authors: A
authors: Gronowska-Senger
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002338:Carotenoids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009566:Nitrates / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000378:metabolism; D019207:beta Carotene
chemical_list: D009566:Nitrates; D009573:Nitrites; D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids
vernacular_title: Azotany i azotyny a wykorzystanie beta-karotenu. CZ. I. Wpływ zróznicowanch ilości azotanów i azotynów zawartych w diecie na wykorzystanie beta-karotenu przez organizm szczura.