title: Postmortem diagnosis of acute megakaryocytic leukemia. Usefulness of immunohistochemistry and tissue hemogram.
abstract: An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)-positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa-positive blasts and megakaryoblasts were deposited massively in lymph nodes. Immunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultrastructural platelet peroxidase in autopsy materials is difficult.
authors: Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
authors: A
authors: A
authors: Umezawa
authors: T
authors: T
authors: Yamada
authors: Y
authors: Y
authors: Ogawa
authors: S
authors: S
authors: Kuramochi
authors: Y
authors: Y
authors: Watanabe
mesh_terms: D000368:Aged; D001344:Autopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism
chemical_list: D010980:Platelet Membrane Glycoproteins