HLA class II and T cell receptor gene polymorphisms in psoriatic arthritis and psoriasis.
HLA-DRB, DQA and DQB genes as well as the T cell receptor (TcR) alpha, beta, and gamma genes were studied by Southern blot analysis of genomic DNA from patients with psoriatic arthritis (PsA) and psoriasis alone (Ps). A subtype of DR7, DR7a, was found in 38.8% of patients with PsA, 41.5% of patients with Ps, and in 8% of healthy individuals (N) (PsA vs N: pc = 0.0002, RR = 7.1; Ps vs N: pc = 0.0002, RR = 7.9). No association with TcR genes was found. Our findings suggest either that the DR7a allele may be in linkage disequilibrium with HLA-Cw6 or that it may be an important susceptibility factor for PsA and Ps.
Sakkas
L I
LI
Division of Medicine, UMDS, Guy's Hospital, London, UK.
Loqueman
N
N
Bird
H
H
Vaughan
R W
RW
Welsh
K I
KI
Panayi
G S
GS
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000235:genetics / Q000276:immunology*; D015139:Blotting, Southern; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism*
D000949:Histocompatibility Antigens Class II; D011971:Receptors, Immunologic