The transient increase of urinary digitalis-like substance excreted during excess sodium intake in reduced renal mass rats.
Urinary immunoreactive endogenous digitalis-like substance (EDLS) excretion was studied in gradually reduced renal mass rats (RRM). Urinary EDLS increased immediately after the start of 1% NaCl ingestion, then it returned to the basal level 2 weeks later. Both urinary sodium excretion and urinary EDLS were significantly higher in 3/6 and 4/6 RRM than in control until 2 weeks after starting 1% NaCl. However, there was no difference in blood pressure between the groups. Transient EDLS increase may play an important role in maintaining sodium and water homeostasis, but its transient increase apparently does not contribute to blood pressure elevation.
Nakagawa
M
M
Second Department of Internal Medicine, Sapporo Medical College, Japan.
Shimamoto
K
K
Matsuda
K
K
Saitoh
S
S
Nakagawa
H
H
Ura
N
N
Iimura
O
O
D000818:Animals; D001794:Blood Pressure; D001798:Blood Proteins / Q000652:urine*; D001835:Body Weight; D002298:Cardenolides; D004077:Digoxin; D008297:Male; D009392:Nephrectomy / Q000379:methods; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000652:urine; D013997:Time Factors
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D012965:Sodium Chloride; D004077:Digoxin