[The individual characteristics of the excretion of benzo(a)pyrene metabolites in rats].
Assessment of individual peculiarities of carcinogen metabolism in the body opens up new vistas in predicting individual sensitivity to these agents. The authors developed a spectrofluorometric [correction of spectrofluorescence] technique to assay concentrations of carcinogenic benzo(a)-pyrene (BP) metabolite (7,8-BP) and a product of its detoxication (3-BP) in excreta of male rats who had been given a single dose of 200 mg/kg of benzo(a)pyrene intraperitoneally. Ten-thirty times daily variations in individual levels of both metabolites were accompanied by less variation in their total amount. Parameters of BP metabolism perhaps can be used for predicting individual risk of BP-induced tumor development.
Savochkina
I V
IV
Dikun
P P
PP
Zabezhinskiĭ
M A
MA
Iamshanov
V A
VA
Likhachev
A Ia
AIa
D000818:Animals; D001564:Benzo(a)pyrene / Q000032:analysis / Q000493:pharmacokinetics*; D001580:Benzopyrenes / Q000032:analysis; D001711:Biotransformation; D004101:Dihydroxydihydrobenzopyrenes / Q000032:analysis; D005243:Feces / Q000737:chemistry; D008297:Male; D051381:Rats; D013050:Spectrometry, Fluorescence / Q000379:methods; D013997:Time Factors
D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; C017228:benzo(a)pyrene 7,8-dihydrodiol; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene
Individual'nye osobennosti ékskretsii metabolitov benz(a)pirena u krys.