Anti-stress activity in a muramyl-dipeptide.
N-Acetylmuramyl-L-alanyl-D-isoglutamine and some of its derivatives have been examined for anti-stress activity. Amongst these, N-palmitoylmuramyl-L-alanyl-D-isoglutamine is shown to considerably enhance the capacity of animals to endure various types of stress. This indicates that besides acting as immunomodulators and sleep regulators, muramyl dipeptides may also act as anti-stress agents.
Singh
N
N
Upgraded Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Jain
R K
RK
Gupta
C M
CM
Anand
N
N
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000818:Animals; D028001:Eleutherococcus; D005260:Female; D000860:Hypoxia / Q000150:complications; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010807:Physical Endurance / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology; D013315:Stress, Psychological / Q000150:complications / Q000628:therapy*
D007155:Immunologic Factors; D010936:Plant Extracts; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C060520:N-palmitoylmuramyl-alanyl-isoglutamine