[In vitro growth of periodontal ligament fibroblasts between bone and root slices].
In a first experiment the proliferation and growth kinetics of periodontal ligament fibroblast monolayers generated from human healthy (HPDL) and diseased (DPDL) periodontia were compared. In a second experimental series a periodontal ligament-like space was developed by laying a root slice inside a bony ring slice on the bottom of a tissue culture petri dish and leaving a space of about 0.5 mm between both structures. HPDL cells showed a higher proliferation rate than DPDL cells. Growing into the space between the slices, the PDL cells built up a matrix which was composed of cells and fibrils. HPDL cells built up the matrix more rapidly than DPDL cells.
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Poliklinik für Zahnerhaltung und Parodontologie der Universität Regensburg.
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D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D005260:Female; D005347:Fibroblasts; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D010510:Periodontal Diseases / Q000503:physiopathology; D010513:Periodontal Ligament / Q000254:growth & development* / Q000648:ultrastructure
In-vitro-Wachstum von Desmodontalfibroblasten zwischen Knochen- und Zahnwurzel-Scheiben.