[Tag 72: a new tumor-associated antigen identified by a monoclonal antibody].
In order to evaluate the usefulness of Tag 72--tumor associated antigen assay--in gastroenterology, we have studied with Ca 72-4 radioimmunoassay (Centocor) 551 patients suffering benign (233) and neoplastic (318) gastrointestinal diseases and 205 normal controls. The cut-off point was fixed at 6 U/ml. Only in gastric cancers, the Tag 72 assay, with the proposed method, provide additional information in this pathology (sensitivity 30%, specificity 98.7%). The most striking observation to be made from the current study is a poor sensitivity of the test for gastrointestinal cancers, but rather the excellent specificity of the Ca 72-4 IRMA with respect to benign gastrointestinal diseases. The sensitivity of Ca 72-4 assay, vs Ca 19-9 and CEA, for the same diseases, is less, but specificity is better.
Piantino
P
P
Divisione di Gastroenterologia, U.S.L. VIII, Ospedale Molinette, Torino.
Fusaro
A
A
Daziano
E
E
Polloni
R
R
Mosso
R
R
Cacace
G
G
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000276:immunology; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000276:immunology; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D011933:Reagent Kits, Diagnostic; C047052:tumor-associated antigen 72
Tag 72: un nuovo antigene tumore associato riconosciuto da un anticorpo monoclonale.