Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma.
Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0 +/- 7.1 U/10(11) platelets, which is significantly lower than that of 56.4 +/- 12 U/10(11) platelets in the controls (P less than 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.
Hasselmark
L
L
Dept. of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden.
Malmgren
R
R
Unge
G
G
Zetterström
O
O
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001249:Asthma / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005979:Glutathione Peroxidase; D012643:Selenium