[Cerebral disseminated lupus erythematosus; brain-racking for patient and physician].
A 30-year-old woman, who in the past was diagnosed as having systemic lupus erythematosus (SLE) and had been treated accordingly, consulted us with neuropsychiatric symptoms, including mutism and catatonia. ANA and anti-dsDNA in serum were negative, and she did not fulfill the ARA criteria for a diagnosis of SLE. However, in view of her history and the fact that she developed convulsions and a transient, unexplained period of leukopenia during admission, her current illness could be interpreted as a cerebral manifestation of SLE. After increasing the dosage of prednisone, she recovered almost completely from this episode. The literature concerning possible procedures to diagnose neuropsychiatric manifestations of SLE is reviewed; it turns out that especially the primary form of cerebral SLE often causes diagnostic problems.
Prins
J M
JM
Academisch Medisch Centrum, afd. Interne Geneeskunde, Amsterdam.
de Glas-Vos
J W
JW
D000328:Adult; D002389:Catatonia / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D009155:Mutism / Q000209:etiology*; D019965:Neurocognitive Disorders / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage
D006220:Haloperidol; D011241:Prednisone
Cerebrale lupus erythematosus disseminatus: hoofdbrekens voor patiënt en arts.