[Increased proteolytic activity of cathepsin D in the skin of rats after administration of various anti-inflammatory drugs].
Cathepsin D activity and type I and III collagens content in the skin of rats treated with some antiinflammatory drugs (acetylsalicylic acid, phenylbutazone, indomethacin, colchicine and prednisone) were evaluated. It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue. The correlation between type I collagen content and proteolytic activity was noticed.
Pałka
J A
JA
Zakładu Biochemii Akademii Medycznej w Białymstoku.
Galewska
Z
Z
Wróbel
K
K
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002402:Cathepsin D / Q000378:metabolism*; D003078:Colchicine / Q000494:pharmacology; D003094:Collagen / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D003094:Collagen; D002402:Cathepsin D; D010653:Phenylbutazone; D001241:Aspirin; D003078:Colchicine; D011241:Prednisone; D007213:Indomethacin
Wzrost aktywności proteolitycznej katepsyny D w skórze szczurów traktowanych niektórymi lekami przeciwzapalnymi.