Inhibition of protein kinase C by oxidation products of retinol.
Retinol has little effect on the activity of protein kinase C. However, air oxidation of retinol produces products which are inhibitory to this enzyme. These results are consistent with a suggestion that the activity of protein kinase C is modulated by the bulk biophysical properties of its environment. The facile susceptibility of retinol to oxidation, as demonstrated by HPLC analysis, explains some of the discrepant reports of its effects on the activity of protein kinase C.
Epand
R M
RM
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
McCallum
C
C
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D010084:Oxidation-Reduction; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D051381:Rats; D014801:Vitamin A / Q000737:chemistry / Q000494:pharmacology*
D014801:Vitamin A; D011493:Protein Kinase C