Accumulation of carbon disulphide metabolites.
Biological monitoring for carbon disulphide (CS2) exposure performed using the iodine-azide test (IAT) and 2-thiothiazolidine-4-carboxylic acid (TTCA) test in urinalysis of workers with high exposure to CS2 (112-142 mg/m3, n = 34), workers with low exposure (4-7 mg/m3, n = 16), and non-exposed university workers (n = 10). Pre-shift and post-shift urine specimens were collected on three consecutive days in the exposed and for only one day in the non-exposed. According to the findings the specificity and the sensitivity seem to be low for the IAT and high for the TTCA test. Contrary to a previous report all pre-shift urine samples showed negative IATs. The TTCA test was positive in pre-shift urine even after 32 to 63.5 h without exposure, and values tended to increase during consecutive days of exposure in highly exposed workers. The possible health implications of these findings should be further investigated.
van Poucke
L
L
Faculty of Pharmaceutical Sciences, State University of Gent, Belgium.
van Peteghem
C
C
Vanhoorne
M
M
D000395:Air Pollutants, Occupational / Q000032:analysis*; D001386:Azides; D002246:Carbon Disulfide / Q000009:adverse effects / Q000032:analysis*; D003404:Creatinine / Q000652:urine; D004784:Environmental Monitoring; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D013844:Thiazoles / Q000652:urine*; D053778:Thiazolidines
D000395:Air Pollutants, Occupational; D001386:Azides; D013844:Thiazoles; D053778:Thiazolidines; C031677:2-thioxo-4-thiazolidinecarboxylic acid; D003404:Creatinine; D002246:Carbon Disulfide