title: [Turnover of microsomal hemeproteins in the guinea pig liver during food sensitization].
abstract: A phase-dependent type of microsomal hemoproteins turnover in liver tissue, estimated by incorporation of 14C-amino-levulinic acid, was detected in guinea pig males in dynamics of alimentary sensitization (1, 7, 14 and 21 days) with ovalbumin and bovine blood serum albumin (BSA). The first phase was expressed as elevated catabolism of microsomal cytochromes simultaneously with a decrease in their turnover; the second phase involved an increase in the hemoproteins biosynthesis. Less distinct sensitization with BSA exhibited the shortened period of the first phase, while activation of aminopyrine N-demethylase and aniline p-hydroxylase as well as considerably increased rate of microsomal cytochromes turnover were found during the second phase in liver tissue.
authors: I N
authors: IN
authors: Marokko
authors: G Iu
authors: GIu
authors: Mal'tsev
authors: V V
authors: VV
authors: Krzhechkovskaia
authors: M M
authors: MM
authors: Gapparov
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D005512:Food Hypersensitivity / Q000378:metabolism*; D006168:Guinea Pigs; D006420:Hemeproteins / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006420:Hemeproteins; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Osobennosti obnovleniia mikrosomal'nykh gemoproteinov pecheni morskikh svinok v dinamike pishchevoĭ sensibilizatsii.