Study of various immunological parameters in the diagnosis of allergy to penicillin G and its derivatives.
The objective of this paper was to draw up an efficient and safe study protocol to diagnose allergy to beta-lactam antibiotics. Seven hundred and fifty patients with clinical histories suggesting penicillin allergy were studied. RAST to penicilloyl G/V, skin tests with PPL, MDM, penicillin G and ampicillin, epicutaneous tests with differed type reactions and a provocation test (in case of the negative results of the other tests) were performed on the patients. The incidence of this pathology is very low (6.5%) and atopic patients do not present greater predisposition to suffer from it than the general population. By carrying out RAST and skin tests with PPL, MDM, penicillin G and ampicillin we arrived at the diagnosis, in the anaphylactic type charts, in 97.5% of the cases. In reactions of a differed type, by performing patch tests we arrived at the diagnosis in 50% of the cases.
Prieto López
C
C
Servicio de Alergologia, Santo Hospital Civil de Bilbao, Spain.
Gamboa
P M
PM
Zugazaga Prieto
M
M
Fernández Martínez
J C
JC
Miguel de la Villa
F
F
Antépara Ercoreca
I
I
D000658:Amoxicillin; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005189:False Positive Reactions; D006801:Humans; D007156:Immunologic Memory; D010400:Penicillin G / Q000009:adverse effects / Q000276:immunology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011852:Radioallergosorbent Test; D012882:Skin Tests
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D010400:Penicillin G