title: Biochemical aspects of the hormonal therapy of endometrial adenocarcinoma.
abstract: This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, polyamine concentration, and the activity of ornithine decarboxylase (ODC), i.e. the first enzyme in polyamine synthesis, were compared before and after the 30/day treatment. The modifications induced by MPA are discussed and related to the pathological picture in an attempt to determine the characteristics of responding tumors.
authors: Dept. B of Obstetrics and Gynaecologic Institute, Univ. of Torino, Italy.
authors: A
authors: A
authors: Lanza
authors: S
authors: S
authors: Colombatto
authors: R
authors: R
authors: Bellino
authors: A
authors: A
authors: Re
authors: T
authors: T
authors: Tessarolo
authors: G
authors: G
authors: Ferraris
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D005958:Glucosephosphates; D011073:Polyamines; D019298:Glucose-6-Phosphate; D009955:Ornithine Decarboxylase; D008525:Medroxyprogesterone