title: [Adenosquamous carcinoma of the skin--ultrastructural and immunohistochemical studies].
abstract: Adenosquamous carcinoma, which arose on the face of a 83-year-old woman was studied ultrastructurally and immunohistochemically. The tumor was composed of squamoid cells and mucinous cells including signet-ring cells. Electron microscopically, the tumor cells developed numerous microvilli on the cell surface, and had tonofilaments, well-developed rough endoplasmic reticulum and secretory granules of a mucinous type in the cytoplasm. The signet-ring cells had a large intracytoplasmic cavity containing fine fibrillar, mucin-like substance. Occasionally observed were intercellular masses, around which the tumor cells formed hemidesmosome-like and basal lamina-like structures. Immunohistochemical staining revealed foci of positive reaction for laminin surrounding the tumor cells. The tumor cells displayed positive stainings for stratified-epithelial keratins, but not for simple-epithelial keratins. From these findings, it was concluded that the present tumor might be a carcinoma of squamous cell origin, showing a mucinous metaplasia.
authors: Department of Dermatology, Niigata University School of Medicine.
authors: F
authors: F
authors: Sakamoto
authors: M
authors: M
authors: Ito
authors: K
authors: K
authors: Oguro
authors: T
authors: T
authors: Kazama
authors: H
authors: H
authors: Fiziwara
authors: M
authors: M
authors: Tezuka
authors: Y
authors: Y
authors: Sato
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D008679:Metaplasia; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000648:ultrastructure*
chemical_list: D007797:Laminin; D003094:Collagen