[Lymphocyte-macrophage regulation of reparative erythropoiesis].
Experiments on mice have shown that the peritoneal cells and splenocytes transferred from anemic animals to normal syngenic recipients cause the appearance of signs of blood formation by the reserve erythropoiesis type, i.e. a decrease of the mitotic index in basophilic erythroblasts and appearance of mitotic oxyphilic erythroblasts. The capacity of peritoneal cells (PC) to transfer this type of the cell differentiation becomes manifest at 30 minutes, achieves its maximum at 2-4 hours, and becomes somewhat reduced at 48 hours after the blood loss. The transfer effect depends on the dose of introduced cells. The PC transfer capacity is higher than that of splenocytes. The lymphocyte inactivation by monoclonal anti-Thy-1,2 antibodies reduces the PC transfer capacity, which is indicative of the role played by the cell cooperation in promoting the transfer effect. Stimulation of erythropoiesis under the effect of macrophages and lymphocytes taken from anemic donors is significant and is accompanied by increased numbers of erythroid cells in the bone marrow and of reticulocytes in the peripheral blood.
Babaeva
A G
AG
Belan
E I
EI
D000740:Anemia / Q000097:blood / Q000503:physiopathology; D000818:Animals; D002454:Cell Differentiation; D004920:Erythropoiesis; D008214:Lymphocytes / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D010537:Peritoneum / Q000502:physiology; D012156:Reticulocytes / Q000502:physiology; D013154:Spleen / Q000166:cytology / Q000502:physiology; D013997:Time Factors
Limfotsitarno-makrofagal'naia reguliatsiia reparativnogo éritropoéza.