title: Response of placental vasculature to high glucose levels in the isolated human placental cotyledon.
abstract: We report the effect of high glucose infusion on vascular resistance in isolated human placental cotyledons perfused with Krebs-Ringer-bicarbonate solution containing 80 mg/dl (4.4 mmol/L), 160 mg/dl (8.8 mmol/L), or 320 mg/dl (17.6 mmol/L) D-glucose (n = 6). Placental vascular resistance remained constant during 25-minute perfusion periods with 80 mg/dl followed by 160 mg/dl glucose solution. Subsequent perfusion with 320 mg/dl glucose produced a significant increase in placental vascular resistance. Placentas were also studied in which the placental cotyledon was sequentially perfused for 25-minute periods with solutions containing glucose at 80 mg/dl followed immediately by 320 mg/dl (n = 5). Placental vascular resistance remained constant throughout perfusion with 80 mg/dl glucose solution but increased significantly after beginning perfusion with 320 mg/dl glucose. We conclude that the increase in placental vascular resistance appears to be a function of the high glucose level rather than the duration of glucose perfusion.
authors: Department of Pediatrics, University of Texas Medical School, Houston.
authors: J B
authors: JB
authors: Roth
authors: J A
authors: JA
authors: Thorp
authors: S M
authors: SM
authors: Palmer
authors: P C
authors: PC
authors: Brath
authors: S W
authors: SW
authors: Walsh
authors: S S
authors: SS
authors: Crandell
mesh_terms: D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects; D011247:Pregnancy; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005947:Glucose