Plasma cortisol distribution in the pig from birth to six weeks of age.
Plasma levels of cortisol and percent distribution of cortisol among protein-bound (corticosteroid-binding globulin (CBG) and albumin) and unbound forms were measured in naturally born/conventionally reared pigs from birth to 6 weeks of age. Total cortisol and percent unbound cortisol were highest in pigs at birth and decreased (p less than 0.01) in a linear fashion over the sampling period. Percent CBG-bound cortisol was lowest on days 3-21 relative to the peak value seen on day 42. However, actual CBG-bound cortisol was not different after day 1. Percent albumin-bound cortisol was highly correlated with percent CBG-bound cortisol (r = -0.90; p less than 0.001). These results suggest that a rapid shift in cortisol distribution from unbound and albumin-bound forms to that which is bound to CBG occurs by approximately day 28 of age in the neonatal pig.
Kattesh
H G
HG
Department of Animal Science, University of Tennessee, Knoxville.
Charles
S F
SF
Baumbach
G A
GA
Gillespie
B E
BE
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D006400:Hematocrit; D006854:Hydrocortisone / Q000097:blood*; D012709:Serum Albumin / Q000378:metabolism; D013552:Swine / Q000254:growth & development*; D014156:Transcortin / Q000378:metabolism
D012709:Serum Albumin; D014156:Transcortin; D006854:Hydrocortisone