[The effect of the complex platinum (IV) compound oxoplatinum on the immune system].
The effect of a Pt (IV) complex compound--oxoplatinum on the humoral and cell immunity in mice was studied. It was established that the drug produced dose-dependent inhibition of T-dependent humoral response to ram erythrocytes. Oxoplatinum appeared to be a costimulator of a mitogen phytohemagglutinin in lymphocyte proliferation slightly influencing allogen-induced proliferation. The stimulation of T-lymphocyte cytotoxicity by small doses of oxoplatinum was also found.
Brin
E V
EV
Rytenko
A N
AN
Uteshev
B S
BS
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007114:Immunization; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV
Nekotorye aspekty vliianiia kompleksnogo soedineniia platiny (IV)-oksoplatiny na immunnuiu sistemu.