Reflex modification and the detection of toxicant-induced auditory dysfunction.
There are numerous environmental chemicals that adversely impact sensory functioning in exposed populations. Test methods are needed that can rapidly and efficiently assess the potential of chemicals to induce sensory toxicity. Reflex modification of the startle response is a technique that provides rapid, objective and quantitative assessments of sensorimotor function. This procedure has been shown to be sensitive to a variety of neurotoxic compounds. Reflex modification can also provide independent estimates of chemical-induced alterations in both sensory and motor function. Future efforts should focus on expanding the use of this procedure in both the identification and characterization of neurotoxic chemicals.
Crofton
K M
KM
Neurotoxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D003216:Conditioning, Operant / Q000502:physiology; D011597:Psychomotor Performance / Q000187:drug effects; D012022:Reflex, Acoustic / Q000187:drug effects*; D014116:Toxicology / Q000379:methods*