title: The effects of talc pleurodesis on growing swine.
abstract: Talc pleurodesis is an effective means of preventing recurrent pneumothorax. We have successfully applied talc pleurodesis with thoracoscopy in children with cystic fibrosis presenting with pneumothorax. However, little is known about the effects of talc pleurodesis on lung compliance in growing children. Therefore, six young pigs (10 weeks old, weighing 15 +/- 1 kg) were prepared for study. In each pig, one hemithorax underwent thoracoscopy and talc pleurodesis (TALC). The other hemithorax underwent either thoracoscopy alone or no procedure (CONTROL). Dynamic and static respiratory mechanics were studied 5 and 10 weeks later. Air flow and airway pressure were measured to calculate dynamic transpulmonary and transrespiratory compliance, and static transpulmonary compliance. At 5 weeks, dynamic transpulmonary and transrespiratory compliance were less in the TALC lungs when compared with CONTROL lungs. At 10 weeks, the differences in dynamic transpulmonary and transrespiratory compliance between the TALC and CONTROL lungs had resolved. Static compliance was lower in the TALC lungs than in the CONTROL lungs at both 5 and 10 weeks, but this was significant only at 10 weeks. There was an improvement in static compliance in the TALC lungs between 5 and 10 weeks, but this only approached significance. At autopsy, there were marked adhesions and pleural thickening in the talc lungs. Histological examination demonstrated no differences in lung parenchyma between the TALC lungs and the CONTROL lungs. Talc pleurodesis causes a temporary impairment in dynamic transpulmonary and transrespiratory compliance that resolves with time and growth. Static compliance is more persistently compromised, but a trend toward improvement with time and growth exists.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
authors: E D
authors: ED
authors: McGahren
authors: W G
authors: WG
authors: Teague
authors: T
authors: T
authors: Flanagan
authors: B
authors: B
authors: White
authors: B M
authors: BM
authors: Rodgers
mesh_terms: D000818:Animals; D008168:Lung / Q000254:growth & development* / Q000503:physiopathology; D008170:Lung Compliance; D010994:Pleura / Q000254:growth & development; D010995:Pleural Diseases / Q000209:etiology* / Q000503:physiopathology; D011030:Pneumothorax / Q000503:physiopathology / Q000628:therapy*; D013552:Swine; D013627:Talc / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D013627:Talc