Hypoxyradiotherapy of uterine cervix cancer to decrease of acute side-effects and treatment complications.
The authors have reported on preliminary results of hypoxyradiotherapy in the course of external irradiation in patients with uterine cervix cancer from a view-point of the occurrence of acute reactions and treatment complications. A mixture of nitrogen and oxygen containing 8.0 to 8.5% of O2 was used to provoke acute hypoxia during irradiation. The applied doses of external irradiation was simultaneously increased by 40%. On the basis of a randomized study with 120 patients, acute hypoxia was found to protect healthy tissues against post-radiation damage. When the doses of 96 Gy in the paracervical space and that of 75 Gy in the pelvic wall were applied, acute side-effects decreased significantly if compared with a conventional radiotherapeutic procedure (p less than 0.01). Radiological preconditions for using acute hypoxia in radiotherapy are discussed.
Tacev
T
T
Research Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.
Vacek
A
A
Strnad
V
V
Rasovska
O
O
Krystof
V
V
Ptácková
B
B
D001918:Brachytherapy; D002142:Californium / Q000627:therapeutic use; D015687:Cell Hypoxia / Q000528:radiation effects; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D009584:Nitrogen / Q000627:therapeutic use*; D010100:Oxygen / Q000627:therapeutic use*; D010315:Particle Accelerators; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011883:Radium / Q000627:therapeutic use; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*
D011837:Radiation-Protective Agents; C041364:nitrox; D002142:Californium; D009584:Nitrogen; D010100:Oxygen; D011883:Radium