Growth hormone response to a bolus injection of 1-44 growth-hormone-releasing hormone in very short children with intrauterine onset of growth failure.
The release of growth hormone (GH) during the 120 min following a bolus venous injection of 1-44 GH-releasing hormone (GHRH) 2 micrograms/kg was studied in 52 prepubertal children aged 8.4 +/- 2.1 years, having a nonfamilial growth deficiency of prenatal onset (-3.26 +/- 1.13 SDS at birth, -3.22 +/- 0.88 SDS at the time of study) and a normal response to conventional GH stimulation tests. GH release reached a peak level of 96.1 +/- 60.2 microU/ml, being significantly higher than that found in 68 non-GH-deficient very short children whose growth failure had a postnatal onset, and not significantly correlated with the response to conventional tests. 26 of the 52 intrauterine growth retardation (IUGR) patients were re-tested with GHRH in similar conditions after 6-12 months of daily subcutaneous injections of GH and 2 days without. They reached at the second test a peak plasma GH level of 91.7 +/- 56.1 microU/ml, not different from their response to the first test. These data could be taken into consideration for long-term studies of the clinical effects of GH in IUGR children with persisting severe growth deficiency.
Job
J C
JC
Hôpital Saint Vincent de Paul, Paris, France.
Chatelain
P
P
Rochiccioli
P
P
Ponte
C
C
Olivier
M
M
Sagnard
L
L
D002648:Child; D002675:Child, Preschool; D005260:Female; D005317:Fetal Growth Retardation / Q000188:drug therapy / Q000378:metabolism*; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000378:metabolism* / Q000627:therapeutic use; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone