Bacterial vaginosis and the effect of intermittent prophylactic treatment with an acid lactate gel.
Intermittent treatment with an acid lactate gel (Lactal, ACO, Sweden) reduced symptoms of bacterial vaginosis (BV) and promoted the reestablishment of the normal vaginal flora of lactobacilli. Forty-two women seriously affected by recurrent BV were initially given acid gel (lactate gel, pH 3.8, 5 ml) to be inserted into the vagina daily for 7 consecutive days. Thereafter they entered into a double blind clinical trial and were treated prophylactically 3 days monthly for 6 months with either lactate gel or a placebo gel. Women treated with the lactate gel were clinically improved, i.e. no signs of BV in 88% compared to 10% in the placebo group (p less than 0.001). The vaginal lactobacilli flora was reestablished in 83% of the lactate group and in 16% of the placebo group. Local intermittent application of lactate gel was found to be free of side effects and is a preferable alternative to repeated treatments with antibiotics in patients with recurrent BV.
Andersch
B
B
Department of Obstetrics and Gynecology, Ostra Sjukhuset, Göteborg, Sweden.
Lindell
D
D
Dahlén
I
I
Brandberg
A
A
D000328:Adult; D000818:Animals; D005260:Female; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000008:administration & dosage / Q000627:therapeutic use*; D019344:Lactic Acid; D014621:Vagina / Q000382:microbiology / Q000503:physiopathology; D014627:Vaginitis / Q000188:drug therapy / Q000517:prevention & control*
D005782:Gels; D007773:Lactates; D019344:Lactic Acid