Indomethacin responsive hypercalcaemia associated with a renal sarcoma.
An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin. There was in vivo and in vitro evidence that hypercalcaemia was mediated by circulatory prostaglandins.
Gibbs
J
J
Hospital for Sick Children, Department of Haematology and Oncology, London.
Dillon
M J
MJ
Lang
S
S
Meghji
S
S
Pritchard
J
J
D003131:Combined Modality Therapy; D015232:Dinoprostone / Q000378:metabolism / Q000652:urine; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D007213:Indomethacin / Q000627:therapeutic use*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000628:therapy / Q000652:urine; D008297:Male; D009392:Nephrectomy; D012509:Sarcoma / Q000150:complications* / Q000628:therapy / Q000652:urine; D014407:Tumor Cells, Cultured
D015232:Dinoprostone; D007213:Indomethacin