[Changes in the lipid composition of mitochondrial membranes during succinate oxidase reaction].
Content of lipids, free cholesterol, cholesterol esters, phospholipids and fatty acid composition were studied in mitochondria incubated in samples containing succinate. Induction of lipid peroxidation, production of malonic dialdehyde and alterations in membranes fluidity were not detected in the preparations of mitochondria within 3 hrs of succinate oxidation. Self-inactivation of mitochondria appears to occur due to an increased uncoupling of oxidative phosphorylation.
Kapitanov
A B
AB
Gribanov
G A
GA
Askarova
E A
EA
Bondareva
E V
EV
Kulakova
S N
SN
D000818:Animals; D007425:Intracellular Membranes / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity; D013386:Succinates / Q000378:metabolism*
D008563:Membrane Lipids; D013386:Succinates; D010088:Oxidoreductases; C022691:succinate oxidase
Izmenenie lipidnogo sostava membran mitokhondriĭ v khode suktsinat-oksidaznoĭ reaktsii.