[Increasing the concentration of free calcium in thymocytes during gamma-irradiation may induce their death].
Free Ca2+ concentration in thymocytes increased 0.5-1.5h after gamma-irradiation (10 Gy) as was measured by Quin-2AM fluorescent probe. Cycloheximide, a protein synthesis inhibitor, suppressed Ca2+ increase and inhibited radiation-induced thymocyte death. EL-4 thymoma cells did not exhibit any changes in free Ca2+ concentration and interphase death after gamma-irradiation. It is believed that the radiation-induced increase of free Ca2+ concentration in thymocytes may induce their death.
Gabaĭ
V L
VL
Mosin
A F
AF
Poverennyĭ
A M
AM
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000166:cytology* / Q000528:radiation effects
D003037:Cobalt Radioisotopes; D002118:Calcium
Povyshenie kontsentratsii svobodnogo kal'tsiia v timotsitakh pri gamma-obluchenii mozhet byt' induktorom ikh gibeli.