[Management with antithrombin III concentrate in a pregnant woman with hereditary antithrombin III deficiency].
Pregnant women with hereditary antithrombin III (AT-III) deficiency are frequently associated with thromboembolic disorders. We have treated a pregnant woman with hereditary AT-III deficiency, who had suffered from thromboembolic disorders at her past three gestations, with AT-III concentrate. Dosage of AT-III concentrate to maintain plasma AT-III activity over 80% was 3,500 units per week during second and third trimesters, but more frequent administration was necessary around delivery. In recent reports, pregnant women with hereditary AT-III deficiency had been treated with heparin or warfarin except for during abortion and delivery, in which time AT-III concentrate was widely utilized. But the use of heparin or warfarin during gestation is occasionally harmful, AT-III concentrate should be chosen for management in pregnancy in women with hereditary AT-III deficiency.
Higuchi
M
M
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya.
Konya
H
H
Tanaka
H
H
Masuda
H
H
Nishida
Y
Y
Koyama
T
T
Suehiro
A
A
Kakishita
E
E
Ishita
K
K
D000328:Adult; D000990:Antithrombin III / Q000627:therapeutic use; D020152:Antithrombin III Deficiency; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000517:prevention & control*; D013923:Thromboembolism / Q000517:prevention & control*
D000990:Antithrombin III