[Influence of the recipient's age on the effect of transplanting lymphoid organs from newborn donors].
The development of immunological capacity of newborn thymus and spleen grafted under the kidney capsule of different-age recipients was investigated. The grafts functions appear to depend strongly upon the macroenvironment of the organism where their development occurs. Therefore+ the favourable influence of young environmental factors, gradually decreasing with the recipient age to become immunosuppressive in old animals is obtained. These data indicate a predominant significance of the macroenvironmental factors both in maturation of the immune system and its alteration during aging.
Butenko
G M
GM
Institute of Gerontology, Academy of Medical Sciences of the USSR, Kiev.
Kharazi
A I
AI
Pishel'
I N
IN
D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000917:Antibody Formation; D002467:Cell Nucleus / Q000473:pathology; D007108:Immune Tolerance / Q000502:physiology; D007668:Kidney; D051379:Mice; D008808:Mice, Inbred CBA; D012038:Regeneration / Q000276:immunology; D013154:Spleen / Q000637:transplantation*; D013950:Thymus Gland / Q000637:transplantation*; D016042:Transplantation, Heterotopic / Q000276:immunology*
Vliianie vozrasta retsipienta na éffekt transplantatsii limfoidnykh organov novorozhdennykh donorov.