Verapamil versus nifedipine in slow-release preparations for the treatment of mild to moderate hypertension.
A crossover study with 24-hour ambulatory blood pressure monitoring was conducted on 30 hypertensive patients, using slow-release preparations of verapamil and nifedipine. Both drugs proved effective hypotensive agents. Nifedipine was slightly, but not significantly, more potent. Fewer side effects were observed with verapamil, but both drugs were well tolerated.
Shamiss
A
A
Hypertension Unit, Chaim Sheba Medical Centre, Tel Hashomer, Israel.
Meisel
S
S
Nussinovitch
N
N
Rosenthal
T
T
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage* / Q000009:adverse effects; D014700:Verapamil / Q000008:administration & dosage* / Q000009:adverse effects
D003692:Delayed-Action Preparations; D014700:Verapamil; D009543:Nifedipine