Reproductive failure in mink and ferrets after intravenous or oral inoculation of Campylobacter jejuni.
Four pregnant mink and seven pregnant ferrets, including five with previous exposure and specific antibody, were injected intravenously with 10(8)-10(10) colony-forming units of Campylobacter jejuni. All 11 pregnancies failed 1-16 days after infection, with results ranging from fetal resorption to expulsion of dead or premature living kits. In every case, uterine contents (placenta, uterine fluid and/or kits) were culture-positive for C. jejuni. Three pregnant mink and nine pregnant ferrets, including four with previous exposure and antibody, were fed 10(9)-10(11) C. jejuni. Two of the mink aborted; kits of all three were culture-positive, but those of one female survived. Seven of the nine ferrets aborted, with two having culture-positive uterine contents. None of 28 uninfected ferret control pregnancies ended in abortion. The most prominent histological feature observed was severe placentitis, which appears to be a more likely cause of Campylobacter-induced abortion than direct pathogenic effects on infected kits. These results suggest that infection of mink or ferrets with C. jejuni during pregnancy poses a serious risk of reproductive failure, even for previously exposed females.
Bell
J A
JA
Department of Veterinary Science, University of Wisconsin, Madison 53706.
Manning
D D
DD
D000034:Abortion, Veterinary / Q000209:etiology; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002169:Campylobacter Infections / Q000150:complications / Q000382:microbiology / Q000662:veterinary*; D016123:Campylobacter jejuni / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification*; D015169:Colony Count, Microbial; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary; D005243:Feces / Q000382:microbiology; D005260:Female; D005289:Ferrets; D005313:Fetal Death / Q000209:etiology / Q000662:veterinary; D005327:Fetal Resorption / Q000209:etiology / Q000662:veterinary; D008907:Mink; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000662:veterinary*
D000907:Antibodies, Bacterial