title: Centrifugal intensity and duration as countermeasures to soleus muscle atrophy.
abstract: Mechanical acceleration is a countermeasure that may be employed to prevent atrophy of slow-twitch muscle during non-weight bearing. In the present study, daily centrifugation of rats for different durations (1 or 2 h) and at different gravitational intensities (1.5 or 2.6 G) was used to test whether mechanical acceleration could ameliorate the atrophy of the soleus muscle induced by non-weight bearing (tail-traction model). The soleus muscle atrophied 32% during 7 days of non-weight bearing without countermeasures. Centrifugation treatment did not completely prevent atrophy relative to precontrol wet weight of the soleus muscle. Non-weight-bearing groups receiving 2-h daily treatments of 1, 1.5, or 2.6 G had 48, 56, and 65%, respectively, of the atrophy observed in the non-weight-bearing-only group compared with the precontrol group. No evidence was obtained that centrifugation at 2.6 G was more effective than exposure to 1 or 1.5 G as a countermeasure to non-weight-bearing-induced atrophy of the soleus muscle.
authors: Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.
authors: D S
authors: DS
authors: D'Aunno
authors: D B
authors: DB
authors: Thomason
authors: F W
authors: FW
authors: Booth
mesh_terms: D000818:Animals; D001835:Body Weight; D002498:Centrifugation; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D006112:Gravitation; D009124:Muscle Proteins / Q000378:metabolism; D009133:Muscular Atrophy / Q000209:etiology / Q000517:prevention & control*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D009124:Muscle Proteins