title: A comparison of ibuprofen and ibuprofen-codeine combination in the relief of post-operative oral surgery pain.
abstract: Non-steroidal anti-inflammatory analgesics are commonly prescribed to out-patients who have undergone oral surgical procedures, since they are said to provide excellent pain relief for mild to moderate pain, allied with minimal side-effects. One hundred patients were entered into a randomised clinical trial to compare the efficacy of a simple non-steroidal analgesic with that of a combination analgesic compound following the removal of lower third molars under local anaesthesia. Pain scores were measured for patients post-operatively by means of a verbal rating scale for 3 days and data were analysed using the Mann-Whitney U-test. Results suggest that this combination product offers no advantages (but shows definite disadvantages) when compared to an effective non-steroidal anti-inflammatory product.
authors: Department of Oral and Maxillofacial Surgery, Turner Dental School, Manchester.
authors: G M
authors: GM
authors: Walton
authors: J P
authors: JP
authors: Rood
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003061:Codeine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D004338:Drug Combinations; D003061:Codeine; D007052:Ibuprofen