[Clinical study of male patients with primary biliary cirrhosis (PBC)].
We studied 10 male and 23 female patients with PBC to determine whether the clinical and histological features of this disease differed in male and female patients. There were no significant difference between men and women in age distribution and biochemical examinations. In female patients, autoimmune associated conditions such as sicca syndrome, Raynaud syndrome and arthritis were observed 22%, 13% and 36%, respectively. By contrast, no male patients developed those conditions. 80% of the male patients and 70% of the female patients belonged to asymptomatic PBC, and early histological stage, such as Scheuer's I and II were observed 90% of the male patients and 78% of the female patients, respectively. No male patients showed clinical or histological progression during follow-up period (median was 64 months). Nevertheless, not a few female patients showed progression including 3 cases who died during the follow-up period (median was 47 months). We concluded that male patients with PBC tend to have favorable prognosis comparing to female patients.
Shibata
M
M
Department of Internal Medicine, Kawasaki Central Hospital.
Ueno
Y
Y
Yoshida
N
N
Yamamuro
W
W
Kubo
S
S
Shimada
N
N
Okada
T
T
Sato
G
G
Hatori
T
T
Onozuka
Y
Y
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006403:Hematologic Tests; D006801:Humans; D008099:Liver / Q000473:pathology*; D008105:Liver Cirrhosis, Biliary / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors