[Comparison of the reactivity of pulmonary tissue and pulmonary vessels in ontogenesis].
Reactivity of the lung tissue and of a. pulmonalis has been followed by means of isometric contraction of isolated strips. Histamine, acetylcholine and prostaglandin F2 alfa (PGF2 alfa) contracted the lung strips, the amplitude of histamine and acetylcholine induced contraction being significantly higher in grown guinea pigs than in foetuses. Strips of a. pulmonalis reacted with contraction in response to histamine and PGF2 alfa, they were non-reactive against acetylcholine. Magnitude of response of the strips of a. pulmonalis obtained from grown animals was significantly greater only after administration of PGF2 alfa in concentration of 10(-4) mol.l-1. Values of EC50 were significantly changed only by influence of acetylcholine on the lung strips. Isolated preparations of lung and vessel strips allow to characterize pharmacodynamic properties of the lung tissue. They represent a contribution to the evaluation of lung reactivity to xenobiotics.
Bobák
L
L
Katedry farmakológie LFUK v Bratislave a Ustavu experimentálnej farmakológie SAV v Bratislave.
Kristová
V
V
Bilcíková
L
L
Kriska
M
M
D000109:Acetylcholine / Q000494:pharmacology; D000375:Aging / Q000502:physiology*; D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D011651:Pulmonary Artery / Q000502:physiology*
D006632:Histamine; D015237:Dinoprost; D000109:Acetylcholine
Porovnanie reaktivity pl'úcneho tkaniva a pl'úcnych ciev v ontogenéze.