title: A Veterans Administration Cooperative Study of biphasic calcium phosphate ceramic in periodontal osseous defects.
abstract: One hundred thirty-seven V.A. patients were randomized to one of three treatment groups to evaluate the efficacy of biphasic calcium phosphate (BCP) ceramic in the treatment of periodontal osseous defects. This material was tested against both autogenous bone implant and open flap curettage procedures. Baseline probing attachment level, Navy plaque index, and gingival index were recorded for all patients. These parameters were monitored for 3 years. At the end of this period, 101 patients had completed the study. Although the plaque and gingival indices steadily increased with time, there were no statistically significant differences among the treatment groups. Patients in the ceramic group had a gain in attachment level of 1.0 mm; those in the curettage group, 0.9 mm; and 0.4 mm for those in the bone implant group. Although the BCP patients had a greater gain, the difference was not statistically significant. In this veteran population, not only did BCP patients fail to outperform those in the control groups, all three treatment groups were similarly ineffective.
authors: V.A. Medical Center, Milwaukee, WI.
authors: E B
authors: EB
authors: Nery
authors: K K
authors: KK
authors: Lee
authors: S
authors: S
authors: Czajkowski
authors: J J
authors: JJ
authors: Dooner
authors: M
authors: M
authors: Duggan
authors: R F
authors: RF
authors: Ellinger
authors: J M
authors: JM
authors: Henkin
authors: R
authors: R
authors: Hines
authors: M
authors: M
authors: Miller
authors: J W
authors: JW
authors: Olson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation; D002130:Calcium Phosphates; D002516:Ceramics; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000000981:diagnostic imaging / Q000473:pathology; D019736:Prostheses and Implants; D011859:Radiography; D013357:Subgingival Curettage; D013524:Surgical Flaps; D014481:United States; D014493:United States Department of Veterans Affairs
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous