Glucose utilization and disposal in cardiothoracic and skeletal muscles during the starved-to-fed transition in the rat.
Glucose utilization indices (GUI) increased to fed values in diaphragm and oxidative skeletal muscles and exceeded fed values in non-oxidative muscles within 2 h of re-feeding chow to 48 h-starved rats. Cardiac GUI reached fed values only after 7 h. Glycogen deposition accounted for most of the glucose phosphorylated in skeletal muscle over the first 2 h in oxidative muscles and over the first 4 h in non-oxidative muscles. In oxidative muscles, the contribution of glycogen deposition to total glucose 6-phosphate disposal diminished as re-feeding was extended from 2 to 6 h.
Sugden
M C
MC
Department of Biochemistry, Queen Mary and Westfield College, London, U.K.
Liu
Y L
YL
Holness
M J
MJ
D000818:Animals; D003964:Diaphragm / Q000378:metabolism; D004435:Eating; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006019:Glycolysis; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007700:Kinetics; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies