[EEG analysis of the effectiveness of the benzodiazepine antagonist RO 15-1788 after diazepam sedation].
In ten volunteers given diazepam, a new diazepam antagonist RO 15-1788 was administered and the effectiveness of this drug was analyzed on EEG. EEG electrodes were attached at C3 and C4 taking right and left ear lobes as indifferent electrodes. EEG trend monitor used by us was equipped with a Fourier analyzer as well as a conventional EEG recorder. EEG was recorded first for about 15 minutes at rest with eyes closed, followed by intravenous injection of 10 mg diazepam. At the end of the test, the antagonist, RO 15-1788 0.5-0.8 mg was administered. Slow waves and alpha waves were frequently found at rest with eyes closed. After diazepam administration, however, power spectrum percent in rapid waves (13-17.5 Hz) mainly consisting of beta waves increased from 8.0 +/- 1.3% (mean +/- SE) to 19.9 +/- 2.2%. These changes were statistically significant (P less than 0.05). At the end of procedures RO 15-1788 was administered and percent of power spectrum in beta waves decreased from 17.4 +/- 2.8% to 9.5 +/- 1.5%. These changes were also statistically significant (P less than 0.05). The sedative effect of diazepam may be evaluated by monitoring these rapid waves since the antagonizing effect of RO 15-1788 is demonstrated on EEG.
Amaki
Y
Y
Department of Anesthesia, Jikei University School of Medicine, Tokyo.
Horiguchi
T
T
Takinami
M
M
Kobayashi
K
K
D000328:Adult; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005442:Flumazenil / Q000494:pharmacology*; D006801:Humans; D008297:Male
D005442:Flumazenil; D003975:Diazepam