title: Calcitonin secretion rate in elderly normal subjects.
abstract: The aim of the study was to investigate the metabolic clearance rate (MCR) and the secretion rate (SR) of calcitonin (CT) in elderly men and women (mean age +/- SE: 75 +/- 3 and 78 +/- 3 yr, respectively). The basal levels of CT were higher in men than in women (9.6 +/- 3.2 vs 6.0 +/- 1.5 pg/ml; p less than 0.05). The MCR was not significantly different between sexes (905 +/- 54.2 vs 810 +/- 165.1 l/day). In contrast, CT SR was significantly higher in male subjects compared to women (8.7 +/- 3.1 vs 4.8 +/- 1.5 micrograms/day; p less than 0.05). These findings suggest that only a few units of CT are secreted daily by elderly subjects and that the lower basal values of the hormone in women are probably the result of a lower production rate.
authors: Istituto di Clinica Medica Generale e Terapia Medica, Università di Parma, Italy.
authors: M
authors: M
authors: Pedrazzoni
authors: G
authors: G
authors: Ciotti
authors: L
authors: L
authors: Davoli
authors: G
authors: G
authors: Pioli
authors: G
authors: G
authors: Girasole
authors: T
authors: T
authors: Santini
authors: M
authors: M
authors: Michelini
authors: P P
authors: PP
authors: Vescovi
authors: M
authors: M
authors: Passeri
mesh_terms: D000368:Aged; D002116:Calcitonin / Q000378:metabolism* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D012737:Sex Factors
chemical_list: D002116:Calcitonin