title: [The role of microsomal oxidation processes in the development of haloperidol tolerance during melatonin administration and epiphysectomy in rats].
abstract: A pineal hormone melatonin (1 mg/kg, 24 days) facilitated the formation of tolerance to haloperidol and eliminated the changes produced by it in the processes of microsomal oxidation in rats. Pinealectomy yielded the opposite result. After pinealectomy the normalizing effect of the hormone on the condition of the liver monoxygenase system and the effects of haloperidol weakened.
authors: E B
authors: EB
authors: Arushanian
authors: V V
authors: VV
authors: Zarubin
authors: A V
authors: AV
authors: Popov
authors: T M
authors: TM
authors: Luneva
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010105:Oxygenases / Q000187:drug effects / Q000378:metabolism; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D051381:Rats
chemical_list: D010105:Oxygenases; D006220:Haloperidol; D008550:Melatonin
vernacular_title: Uchastie protsessov mikrosomal'nogo okisleniia v formirovanii tolerantnosti v galoperidolu pri vvedenii melatonina i épifizéktomii u krys.