[Experimental and clinical study of nitazol as an antibacterial drug in the complex treatment of peritonitis].
Antibacterial properties of the Soviet drug nitazol which is a derivative of imidazole were studied. It was shown that nitazol in a dose of 4-8 micrograms/ml was highly active against gram-negative nonsporulating anaerobes, gram-positive anaerobic cocci and spore-forming Clostridia spp. Unlike metronidazole, it was efficient against both standard and clinical strains of facultative anaerobes such as E. coli, S. aureus and Klebsiella spp. isolated from patients with peritonitis and being poly-resistant to antibiotics. It was found in vitro that the antibacterial effect of nitazol was higher when it was used in combination with some antibiotics. It was demonstrated on experimental models of peritonitis caused by Staphylococcus spp. and E. coli in mice that nitazol used alone or in combination with gentamicin had a favourable effect on the animal survival and lifespan. The combination of nitazol with gentamicin was applied in the combined treatment of appendicular peritonitis in 80 children and its high therapeutic efficacy was stated. Nitazol is useful as an antibacterial drug in the combined treatment of children with purulent peritonitis.
Tsyganenko
A Ia
AIa
Topuzov
V S
VS
Kalinichenko
N F
NF
Kovalenko
N I
NI
Davidenko
V B
VB
Gabysheva
L S
LS
Liapunov
N A
NA
Starobinets
Z G
ZG
Osolodchenko
T P
TP
Vasil'chenko
V N
VN
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002648:Child; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D005839:Gentamicins; D007093:Imidazoles
Eksperimental'no-klinicheskoe izuchenie nitazola kak antibakterial'nogopreparata v kompleksnom lechenii peritonitov.