title: Chemotherapy in metastatic nonanaplastic thyroid cancer: experience at the Institut Gustave-Roussy.
abstract: Forty-nine patients with metastatic nonanaplastic thyroid carcinoma were treated over a 10-year period. Five successive chemotherapeutic protocols were used: a combination of doxorubicin, etoposide, 5-fluorouracil and cyclophosphamide; elliptinium acetate; doxorubicin; cisplatin; and the combination of doxorubicin and cisplatin. Results obtained with the different protocols were very disappointing, with only two objective responses (3%). Phase II trials with new chemotherapeutic agents are warranted in selected cases of nonanaplastic metastatic thyroid carcinoma.
authors: Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
authors: J P
authors: JP
authors: Droz
authors: M
authors: M
authors: Schlumberger
authors: P
authors: P
authors: Rougier
authors: M
authors: M
authors: Ghosn
authors: P
authors: P
authors: Gardet
authors: C
authors: C
authors: Parmentier
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013964:Thyroid Neoplasms / Q000188:drug therapy*