HLA-antigens in a Tunisian familial chondrocalcinosis.
Thirty members of a Tunisian family with hereditary chondrocalcinosis were typed for HLA-A, B, and DR antigens: 7 affected and 23 unaffected subjects in three consecutive generations. The haplotype A1 B12 DR3 was found in all affected subjects and in 8 unaffected members. Chondrocalcinosis in this family may be associated with the haplotype A1 B12 DR3. The mode of transmission was autosomal dominant with incomplete penetrance.
Hamza
M
M
Service de Rhumatologie, Hôpital Le Rabta Tunis, Tunisie.
Ayed
K
K
Bardi
R
R
Gebuhrer
L
L
Betuel
H
H
Bardin
T
T
Plaetke
R
R
Lathrop
M
M
D002805:Chondrocalcinosis / Q000208:ethnology / Q000235:genetics*; D003241:Consanguinity; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D005819:Genetic Markers; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree; D014416:Tunisia
D005819:Genetic Markers; D006680:HLA Antigens