Gene mapping of mouse laminin A and B2 subunits using mouse-Chinese hamster somatic cell hybrids.
Laminin is a multichain extracellular matrix glycoprotein found primarily in basement membranes. The molecule is made up of three subunits, designated as A, B1, and B2. Using an 850-base cDNA probe for the mouse laminin A-chain and a 1000-base cDNA probe for the mouse laminin B2 chain, we have screened mouse-Chinese hamster somatic cell hybrids in order to assign the genes for each of these polypeptides to their respective mouse chromosome. We have determined that the mouse laminin B2-chain gene is located on chromosome 1 (confirming this assignment) and the laminin A-chain gene is located on chromosome 17.
Kaye
N W
NW
Department of Anatomy, Cell Biology and Neurobiology, Albany Medical College, New York.
Chung
A E
AE
Lalley
P A
PA
Durkin
M E
ME
Phillips
S L
SL
Church
R L
RL
D000818:Animals; D015139:Blotting, Southern; D006822:Hybrid Cells; D007797:Laminin / Q000235:genetics*; D051379:Mice
D007797:Laminin