Blood pressure in minimal change and other types of nephrotic syndrome.
Blood pressure was evaluated in adult patients (n = 9) and children (n = 57) with nephrotic syndrome and minimal change glomerulonephritis (GN). Prior to steroid treatment in the edematous phase, hypertension was found in 78% of adults (BP greater than or equal to 140/90 mm Hg or antihypertensive treatment other than diuretics) and 95% of children (BP greater than 95 percentile of age). After complete remission, the prevalence of hypertension decreased to 33% in adults and 19% in children. In 21 children with early focal segmental glomerulosclerosis, the prevalence of hypertension (BP greater than 95th percentile) was 91% and 24% after complete remission. In 20 adult patients with membranous GN, the prevalence of hypertension in the edematous phase was 89% and 30% after complete or partial remission. It is concluded that, irrespective of age, hypertension is a common feature of the nephrotic syndrome unrelated to steroid therapy or renal failure.
Küster
S
S
Department of Internal Medicine and Pediatrics, Ruprecht Karl University, Heidelberg, FRG.
Mehls
O
O
Seidel
C
C
Ritz
E
E
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000503:physiopathology; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications / Q000503:physiopathology*; D015995:Prevalence
D000959:Antihypertensive Agents