Sulfur containing compounds as antioxidants.
Several sulfur containing antioxidants have been used for therapeutic use as hepatoprotectors and radioprotectors. In particular the dithiolthione SULFARLEM, used as anticholestatic drug for more than 40 years, is shown to be antioxidant; preliminary pharmacokinetic data in man are presented, and hepatoprotective and radioprotective effect in mice are demonstrated.
Dansette
P M
PM
Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, UA 400 CNRS, Université René Descartes, Paris, France.
Sassi
A
A
Deschamps
C
C
Mansuy
D
D
D000818:Animals; D000975:Antioxidants; D006801:Humans; D013438:Sulfhydryl Compounds / Q000378:metabolism / Q000494:pharmacology*
D000975:Antioxidants; D013438:Sulfhydryl Compounds