Tolerance to lead-induced porphyrin metabolic disorders following lead pretreatment in mice.
The protective effect of pretreatment with lead on lead-induced toxicity was investigated in mice, using some biological parameters such as urinary excretion of delta-aminolevulinic acid (ALA) and coproporphyrin, accumulation of erythrocyte protoporphyrin and inhibition of erythrocyte delta-aminolevulinic acid dehydratase; these are useful indicators for evaluating the effects on health of lead. It was demonstrated that pretreatment with a single intraperitoneal dose of 2 mg Pb/kg, 7 days prior to the challenge dose, prevents in part the increasing excretion of urinary ALA induced by a challenge exposure to lead (200 ppm) in the drinking water for 7 days.
Tomokuni
K
K
Department of Community Health Science, Saga Medical School, Japan.
Ichiba
M
M
D000284:Administration, Oral; D000622:Aminolevulinic Acid / Q000652:urine*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003306:Coproporphyrins / Q000652:urine*; D004361:Drug Tolerance; D007274:Injections, Intraperitoneal; D007854:Lead / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D008297:Male; D051379:Mice; D000623:Porphobilinogen Synthase / Q000097:blood; D011166:Porphyrins / Q000378:metabolism*
D003306:Coproporphyrins; D011166:Porphyrins; D007854:Lead; D000622:Aminolevulinic Acid; D000623:Porphobilinogen Synthase