Plasma oxypurines in gastric and colorectal cancer.
Reverse phase high performance liquid chromatography has been used for the determination of plasma hypoxanthine, xanthine, and uric acid in normal subjects and in patients with gastric and colorectal cancer. Plasma oxypurines are significantly elevated in either type of cancer, while uric acid concentration is only higher in gastric cancer. The variations are related to the stage of the tumors, and the physiopathology of their occurrence is discussed.
Lorenzi
M
M
Istituto di Chimica Biologica, Università di Siena, Italy.
Porcelli
B
B
Vannoni
D
D
Leoncini
R
R
Pizzichini
M
M
Di Stefano
A
A
Pagani
R
R
Marinello
E
E
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D007042:Hypoxanthines / Q000097:blood; D009367:Neoplasm Staging; D011687:Purines / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology; D014527:Uric Acid / Q000097:blood; D014970:Xanthines / Q000097:blood
D007042:Hypoxanthines; D011687:Purines; D014970:Xanthines; D014527:Uric Acid