[Atropine resistance and its significance in the selection of the method of surgical treatment of duodenal ulcer].
Medical vagotomy with atropine allows two types of patients with duodenal ulcer to be distinguished--atropine-resistant and atropine-sensitive. A complicated course of the disease, high values of nocturnal gastric secretion before the operation, and positive Hollander's insulin test after vagotomy are encountered most frequently in atropine-resistant patients. The values of gastrin are significantly higher in these patients than in atropine sensitive patients. In 3-year follow-up periods, recurrence of the ulcer after vagotomy was revealed in 6.5% of atropine-resistant patients but in none of the atropine sensitive patients. Medical vagotomy with consideration for atropine sensitivity may be a reliable prognostic criterion in the choice of the operative intervention in patients with duodenal ulcer.
Nechaĭ
A I
AI
Karachunov
A V
AV
Movchan
K N
KN
Zuev
V K
VK
Ivanov
G N
GN
Fokin
Iu N
IuN
D001285:Atropine / Q000494:pharmacology*; D004351:Drug Resistance; D004381:Duodenal Ulcer / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D011706:Pyloric Antrum / Q000294:innervation / Q000601:surgery*; D013268:Stimulation, Chemical; D014628:Vagotomy / Q000379:methods*
D001285:Atropine
Atropinorezistentnost'i ee znachenie v vybore metoda khirurgicheskogo lecheniia bol'nykh iazvoĭ dvenadtsatiperstnoĭ kishki.