Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats.
Sprague-Dawley rats were maintained on a daily regimen of nicotine, morphine or saline administration for 28 days. Following the discontinuation of the daily drug regimen, rats were given a choice of tap water or a saccharin-water solution. The rats previously receiving morphine drank significantly less saccharin-water solution than did the rats receiving nicotine or saline injections. The failure of the nicotine rats to display a conditioned aversion to the novel saccharin flavor suggests that nicotine did not produce a physiological withdrawal syndrome analogous to morphine withdrawal in this paradigm.
Villanueva
H F
HF
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298.
Arezo
S
S
James
J R
JR
Rosecrans
J A
JA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin; D013375:Substance Withdrawal Syndrome / Q000523:psychology*; D013649:Taste / Q000187:drug effects; D013997:Time Factors
D009538:Nicotine; D012439:Saccharin