title: Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
abstract: The current studies were designed to determine whether chronic overexpression of low density lipoprotein (LDL) receptors in the liver would protect mice from the increase in plasma LDL-cholesterol that is induced by high-fat diets. A line of transgenic mice was studied that express the human LDL receptor gene in the liver under control of the transferrin promoter. When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL. The current data indicate that unregulated overexpression of LDL receptors can protect against diet-induced hypercholesterolemia in mice.
authors: Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas 75235.
authors: M
authors: M
authors: Yokode
authors: R E
authors: RE
authors: Hammer
authors: S
authors: S
authors: Ishibashi
authors: M S
authors: MS
authors: Brown
authors: J L
authors: JL
authors: Goldstein
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000009:adverse effects; D008078:Cholesterol, LDL / Q000097:blood*; D004041:Dietary Fats / Q000009:adverse effects*; D005091:Exons; D015870:Gene Expression; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000517:prevention & control*; D007438:Introns; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D053419:Lipoproteins, IDL; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009693:Nucleic Acid Hybridization; D011401:Promoter Regions, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics*; D014168:Transferrin / Q000235:genetics
chemical_list: D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D004041:Dietary Fats; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D053419:Lipoproteins, IDL; D008079:Lipoproteins, VLDL; D012333:RNA, Messenger; D011973:Receptors, LDL; D014168:Transferrin