Volatile fraction of neem oil as a spermicide.
The volatile, odorous fraction of neem oil coded as NIM-76 obtained by steam distillation was investigated for in vitro spermicidal activity. The data showed that the minimum concentration which inhibited spermatozoal motility was 0.25 mg/ml for rat and 25 mg/ml for human spermatozoa. The effect of the drug on spermatozoal motility was found to be dose-dependent. The activity of this drug was not altered in the presence of vaginal or cervical mucus. Intra-vaginal application of NIM-76 in rabbits showed no irritation to the vaginal mucosa.
Riar
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Ss
Defence Institute of Physiology and Allied Sciences, Delhi Cantt, India.
Devakumar
C
C
Ilavazhagan
G
G
Bardhan
J
J
Kain
A K
AK
Thomas
P
P
Singh
R
R
Singh
B
B
D000818:Animals; D002584:Cervix Uteri / Q000378:metabolism; D002849:Chromatography, Gas; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005989:Glycerides / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009093:Mucus / Q000187:drug effects; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects*; D013729:Terpenes / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology*; D014621:Vagina / Q000187:drug effects
D005989:Glycerides; D010938:Plant Oils; D013089:Spermatocidal Agents; D013729:Terpenes; C002443:neem oil