Effect of H-2 genes on expression of HLA-B27 and Yersinia-induced arthritis.
HLA-B*2705 transgenic mice were continuously backcrossed to mice of the B10 background with various haplotypes. A high level of expression of the HLA-B27 protein was detected on peripheral blood lymphocytes (PBLs) from mice homozygous for H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes by FACS analysis with the ME-1 antibody. A lower level of expression of B27 was observed on PBLs from H-2v mice. Little or no expression of B27 was detected on PBLs from H-2 or H-2d mice. We hypothesize that the HLA-B27 heavy chain is analogous to and competes with endogenous class I heavy chains in the H-2d, H-2q and H-2v haplotypes. Interestingly, other studies in our laboratory have demonstrated that mice with the H-2d and H-2q haplotypes with deletions of certain T cell receptor subsets are more prone to Yersinia-induced arthritis (YIA). Therefore, the mouse model of YIA may provide insights into the mechanisms of HLA-B27-linked spondyloarthropathies in man.
Nickerson
C L
CL
Department of Immunology, Mayo Clinic, Rochester.
Hogen
K L
KL
Luthra
H S
HS
David
C S
CS
D000818:Animals; D001170:Arthritis, Infectious / Q000235:genetics / Q000276:immunology*; D002872:Chromosome Deletion; D015870:Gene Expression; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics*; D006239:Haplotypes; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D015009:Yersinia Infections / Q000235:genetics / Q000276:immunology*
D015796:HLA-B27 Antigen; D011948:Receptors, Antigen, T-Cell