Analysis of antiepileptic drugs.
This review discussed various analytical methods for the determination of antiepileptic drugs and their metabolites in biological tissues. The emphasis was on the reports published since their last review [J. T. Burke and J. P. Thenot, J. Chromatogr., 340 (1985) 199]. Both chromatographic and immunological procedure were cited and compared. Methods for individual and simultaneous quantitation of standard antiepileptic drugs and their metabolites were considered. In addition, a discussion of free drug determination and procedures for new candidate antiepileptic drugs were included.
Kapetanovic
I M
IM
Preclinical Pharmacology Section, NINDS, NIH, Bethesda, MD 20892.
D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans
D000927:Anticonvulsants