title: Released glycoconjugate of indigenous Leishmania major enhances survival of a foreign L. major in Phlebotomus papatasi.
abstract: The effect of Leishmania glycoconjugate in the vector was investigated using Phlebotomus papatasi artificially infected with a Leishmania major strain that this vector does not transmit in nature. Glycoconjugate of the vector-specific strain of L. major was added to the infective meals of some fly groups and the success of infections with or without this substance was compared 4 d later. In the absence of glycoconjugate the parasites survived in 15.6% of the flies, while the addition of 0.5 mg/ml and 2 mg/ml raised the rate of infection to 34.3% and 63.0% respectively. Undigested blood was found in the stomach of 7.8% of the infected flies, whereas following meals with parasites and 2 mg/ml glycoconjugate it was present in 37% of the flies. The results demonstrated that this glycoconjugate increased the viability of the parasites in the unsuitable vector and delayed digestion of the infective meals. In a parallel experiment the glycoconjugate of L. donovani did not affect the survival of the parasites.
authors: Department of Parasitology, Hadassah Medical School, Jerusalem, Israel.
authors: Y
authors: Y
authors: Schlein
authors: L F
authors: LF
authors: Schnur
authors: R L
authors: RL
authors: Jacobson
mesh_terms: D000818:Animals; D002470:Cell Survival; D006001:Glycoconjugates / Q000378:metabolism; D007303:Insect Vectors / Q000502:physiology*; D007895:Leishmania tropica / Q000378:metabolism*; D007896:Leishmaniasis / Q000635:transmission; D010691:Phlebotomus / Q000502:physiology*
chemical_list: D006001:Glycoconjugates