[The advisability of modifying the current outline of blood coagulation].
The necessity of modifying the scheme of blood coagulation employed in the practice of clinicians is determined by the fact that the schemes offered before were short of the following important moments: 1) the whole totality of the mechanisms of factor VII activation (by factors III, XIIa, IXa, Xa, IIa, phospholipids and lipoproteins) and importance of its activation and increase of the level to reveal the risk of the development of the DIC syndrome, thromboses, sudden cardiac death; 2) formation during transformation of fibrinogen to fibrin of high molecular weight complexes of fibrin monomers (stabilized and not stabilized by factor XIIIa), whose presence in the blood plasma and serum provides important evidence for intravascular coagulation; 3) peptide splitting from prothrombin (fragments 1, 2) and fibrinogen (peptides A and B, 1-42, 15-42) the determination of which is also used for revealing activation of the blood and fibrinolytic system. Those and a number of other characteristic features are taken into account in the scheme of blood coagulation offered by the authors. A scheme of the functioning of the main anticoagulant mechanisms (antithrombin III and heparinoids; thrombomodulin, the system of proteins C and S) is also provided.
Barkagan
Z S
ZS
Kuznik
B I
BI
D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology; D015942:Factor VIIa / Q000502:physiology; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D011516:Prothrombin / Q000502:physiology
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; D011516:Prothrombin; D005340:Fibrinogen; D015942:Factor VIIa
O tselesoobraznosti modifikatsii sovremennoĭ skhemy svertyvaniia krovi.