Novel versus familiar ethanol: a comparison of aversive and rewarding properties.
Rats were given a series of the conditioning trials during which sucrose solution was paired with ethanol which had previously been experienced on 0, 3, or 9 occasions. On each conditioning trial, the rats received a Taste Reactivity Trial, a Taste Avoidance Trial, and a Place-Conditioning Trial. After the rats had received 4 conditioning trials, they were given a Conditioned Place Preference Test, a Taste Reactivity (TR) Test, and a Conditioned Aversion Extinction Test. Only the group conditioned with novel ethanol demonstrated aversive TR responses, although all CS + groups eventually demonstrated suppressed ingestive TR responses and enhanced neutral TR responses. Familiarization attenuated, but did not eliminate, ethanol-induced CTAs. There was no evidence of place conditioning.
Davies
B T
BT
Texas A&M University.
Parker
L A
LA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006185:Habituation, Psychophysiologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D013649:Taste
D000431:Ethanol