Plasma and urinary growth hormone and insulin-like growth factor I in children with chronic renal insufficiency.
We investigated the plasma and urinary growth hormone (GH) levels, and plasma insulin-like growth factor (IGF-I) in 15 (8 prepubertal and 7 pubertal) subjects with chronic renal insufficiency. Four of our 7 pubertal patients had a short stature (standard deviation score from -2.7 to -4.0). Significantly increased plasma GH and IGF-I levels were found in pubertal subjects alone (p less than 0.05). The urinary GH levels was significantly increased in prepubertal and pubertal subjects (p less than 0.001 and 0.05, respectively). A significantly inverse correlation between urinary GH excretion and creatinine clearance was found (r = -0.55; p less than 0.05). Increased plasma GH, IGF-I and urinary GH levels seem to suggest a complex alteration of GH and somatomedin metabolism in central and peripheral (receptor) cells.
Perrone
L
L
Department of Paediatrics, University of Naples, Italy.
Sinisi
A A
AA
Criscuolo
T
T
Manzo
T
T
Maresca
G
G
Bellastella
A
A
del Gado
R
R
D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D015592:Immunoradiometric Assay; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D011627:Puberty / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone