title: [Radiation injury of the normal brain tissue after external radiotherapy of brain tumor].
abstract: The calculated dose expressed by neuNSD (or neuret) shows a significant relationship between a therapeutic dose and a post-radiation time in the normal brain injury. An aged patient and a patient with the vulnerable brain in the irradiated field had the high risk of radiation injury. Radiotherapy needs to consider the cost-benefit balance for those risk patients. The hyalinization of the vessels and demyelination were observed even in low-dose radiation areas in non-aged patients, and in aged patients fibrinoid necrosis was observed in low-dose radiation areas. The combination of intraarterial chemotherapy and radiotherapy increased the injury of the brain. If the low-density area existed within the irradiated field on CT, it could be a cause of radiation injury. Steroid and anticoagulant drugs should be given to recover from the condition before radionecrosis.
authors: Dept. of Neurosurgery, Univ. of Tsukuba.
authors: Y
authors: Y
authors: Yoshii
mesh_terms: D000368:Aged; D000375:Aging; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D015376:Nimustine / Q000008:administration & dosage; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D015376:Nimustine