Morphine pharmacokinetics during anesthesia and surgery in patients with burns.
The plasma clearance, plasma half-life, and apparent volume of distribution of morphine during anesthesia and surgery were determined in seven patients with burns and compared with seven age-matched control subjects. The burn group had a significantly lower clearance, longer terminal half-life, and smaller volume of distribution than the control group. The clearance was 12 +/- 2 ml/min/kg, the half-life was 123 +/- 24 minutes, and the volume of distribution was 2.2 +/- 0.4 L/kg for the subjects with burns compared with 25 +/- 3 ml/min/kg, 89 +/- 18 minutes, and 3.2 +/- 0.8 L/kg for the control subjects (p less than 0.001, less than 0.02, and less than 0.02, respectively). These data contrast with the theory that patients with burns have a tolerance to narcotics and suggest the need for further study of the pharmacologic effects of burn injury and surgery.
Furman
W R
WR
Johns Hopkins University School Medicine, Baltimore, Maryland.
Munster
A M
AM
Cone
E J
EJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia; D002056:Burns / Q000378:metabolism / Q000601:surgery*; D002302:Cardiac Output; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000503:physiopathology; D008875:Middle Aged; D009020:Morphine / Q000493:pharmacokinetics*
D009020:Morphine