[Ascitic fluid: the value of various biological tests in the differential diagnosis between cirrhotic and neoplastic ascites].
The authors have analyzed sixty cases of ascites including twenty of neoplastic origin and thirty-six of cirrhotic origin in order to evaluate the usefulness of several laboratory tests for the differential diagnosis of ascites. The tests which gave more than 85% diagnostic accuracy were ascitic fluid concentrations of fibronectin and total protein, serum-ascites gradients of albumin and total protein concentrations, ascitic fluid concentrations of albumin and cholesterol. The last three tests gave a diagnostic accuracy of more than 92% at discriminant levels of 3.8 gr/dl, 1.6 gr/dl and 60 mg/dl, respectively. For these six tests, neoplastic ascites due to liver metastasis had values intermediate between cirrhotic ascites and neoplastic ascites due to peritoneal carcinomatosis. A serum-ascites albumin gradient of more than 1.1 gr/dl was indicative of portal hypertension in cirrhotic patients; the total protein serum-ascites gradient had a better diagnostic accuracy. Flow cytometry had less diagnostic accuracy than cytology; moreover, all cases with abnormal flow cytometry were already recognized by cytology.
Ghilain
J M
JM
Services de Médecine Interne et d'Oncologie, Hopital de Jolimont.
Henrion
J
J
Schapira
M
M
Majois
F
F
Beauduin
M
M
Heller
F R
FR
D000951:Antigens, Neoplasm / Q000032:analysis; D001201:Ascites / Q000209:etiology* / Q000378:metabolism; D001202:Ascitic Fluid / Q000737:chemistry* / Q000166:cytology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D010534:Peritoneal Neoplasms / Q000150:complications*; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity
D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins; D011506:Proteins
Le liquide d'ascite: intérêt de divers tests biologiques dans le diagnostic différentiel entre ascite cirrhotique et néoplasique.