[The determination of the D-arabinitol content of the blood serum--a method for the diagnosis and monitoring of an invasive candidal infection in cytopenia patients (preliminary data)].
Gas chromatography was used to identify D-arabinitol over time (5-6 times on the average) in the blood serum of 24 patients with fever of unclear etiology. The patients were in a state of cytostatic and/or cytostatic and radiation cytopenia. In 20 donors, D-arabinitol was identified once. In the majority of the donors, that indicator did not exceed 1 microgram/ml, amounting on the average to 0.7 +/- 0.3. In patients with invasive candidiasis, the concentration of D-arabinitol surpassed 1 microgram/ml, reaching 4.0-5.5 micrograms/ml in some patients. In patients colonized with Candida, that indicator also exceeded 1 microgram/ml, not reaching, however, such high values as those seen in invasive candidiasis. Identification of the D-arabinitol level reflects the total activity of the fungi of the Candida genus contaminating the patients' mucous membranes at the moment of investigation irrespective of the process site, whereas monitoring allows one to follow tendencies of that activity and to correct therapy.
Shishkova
T V
TV
Demina
A M
AM
Baranov
A E
AE
Minaev
V A
VA
Ivanova
T A
TA
Tarakanova
M P
MP
Semenova
O I
OI
Protasova
T G
TG
Davydovskaia
T I
TI
Buianov
V V
VV
D002177:Candidiasis / Q000097:blood* / Q000175:diagnosis; D002353:Carrier State / Q000097:blood / Q000175:diagnosis; D002849:Chromatography, Gas; D005335:Fever of Unknown Origin / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D010198:Pancytopenia / Q000097:blood* / Q000150:complications; D013402:Sugar Alcohols / Q000097:blood*
D013402:Sugar Alcohols; C014999:arabitol
Opredelenie soderzhaniia D-arabinitola v syvorotke krovi--metod diagnostiki i monitoringa invazivnoĭ kandidoznoĭ infektsii u bol'nykh s tsitopeniiami (predvaritel'nye dannye).