[A comparative study of the toxic and therapeutic effects of digoxin and its immobilized form].
It was shown on different species of laboratory animals (frogs, mice, rats) that digoxin immobilized on the copolymer was 8-15 times less toxic that its usual preparation. In this case glycoside fixed on the copolymer preserves completely its specific cardiotonic effect, i.e., possesses a wider range of the therapeutic action.
Markova
I V
IV
Mikhaĭlov
I B
IB
Baranovskiĭ
A V
AV
Sukhov
R R
RR
D000818:Animals; D003692:Delayed-Action Preparations; D004077:Digoxin / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004837:Epinephrine; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D009205:Myocarditis / Q000139:chemically induced / Q000188:drug therapy; D005082:Physical Exertion / Q000187:drug effects; D011896:Rana temporaria; D051381:Rats; D013268:Stimulation, Chemical
D003692:Delayed-Action Preparations; D004077:Digoxin; D004837:Epinephrine
Sravnitel'noe izuchenie toksicheskogo i lechebnogo éffektov digoksina i ego immobilizovannoĭ formy.