Radioimmunoguided surgery in primary colon cancer.
Radioimmunoguided surgery (RIGS), the intraoperative use of a hand-held gamma detecting probe (GDP) to identify tissue containing radiolabeled monoclonal antibody (MAb), was performed upon 30 patients with primary colon carcinoma. Each patient received an intravenous injection of MAb B72.3 (1.0 to 0.25 mg) radiolabeled with 125I (5.0 to 1.0 mCi) 8 to 34 days before exploration. The GDP was used to measure radioactivity in colon tissue, tumor bed, nodal drainage areas, and areas of suspected metastases. Antibody localized to histologically documented tumor in 23 of 30 patients (77%). Tumor margins were more clearly defined in 20 of 30 patients (67%). GDP counts led to major alterations in surgical resection in five patients (17%) and changes in adjuvant therapy in four (14%). GDP counts identified occult liver metastases in two patients (7%) and correctly indicated the benign nature of liver masses in three (10%). In four patients (13%), occult nodal metastases were identified. RIGS can precisely delineate tumor margins, define the extent of nodal involvement, and localize occult tumor, providing a method of immediate intraoperative staging that may lessen recurrences and produce higher survival rates.
Nieroda
C A
CA
National Institutes of Health, National Cancer Institute, Bethesda, MD 20892.
Mojzisik
C
C
Sardi
A
A
Ferrara
P J
PJ
Hinkle
G
G
Thurston
M O
MO
Martin
E W
EW
D000911:Antibodies, Monoclonal; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000556:secondary
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes