The role of indium-labelled leukocyte imaging in pyrexia of unknown origin.
Indium-111-labeled white blood cell scanning is often used in the investigation of pyrexia of unknown origin (PUO) to locate an otherwise occult source of sepsis. From a series of 166 white blood cell studies performed for sepsis, 28 cases of true PUO were identified and reviewed. The sensitivity was 60% and specificity 70%, with a positive predictive value of 38% and negative predictive value of 90%. Only 11% of studies revealed a pyogenic cause for PUO. These results are discussed and the potential role of gallium scanning in PUO is raised.
Davies
S G
SG
Radioisotope Department, London Hospital, Whitechapel.
Garvie
N W
NW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004238:Diverticulitis / Q000150:complications; D005260:Female; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008100:Liver Abscess / Q000150:complications; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014334:Tropolone / Q000031:analogs & derivatives*; D014397:Tuberculosis, Pulmonary / Q000150:complications
D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C043895:indium tris(tropolonate); D014334:Tropolone