[The reparative regeneration of the endothelium of the mouse aorta during microsurgical interventions following local gamma irradiation (based on scanning electron microscopic data)].
In experiments with rats, abdominal aorta was subjected to microsurgical anastomosis after local irradiation with doses of 40 and 50 Gy. Irrespective of the time interval between the operation and irradiation the iatrogenic defect was restored completely. With the operation performed 24 h after irradiation the platelet adhesion decreased, the proliferation was inhibited depending on radiation dose, and the pattern of the endotheliocyte migration changed. The above effects were absent with the operation performed one month after irradiation.
Rekhter
M D
MD
Bauman
O A
OA
Sidorov
V B
VB
Mironov
A A
AA
Anisimov
V M
VM
Vialov
S L
SL
Pshenisnov
K P
KP
D000818:Animals; D001012:Aorta, Abdominal / Q000528:radiation effects* / Q000601:surgery*; D003037:Cobalt Radioisotopes; D004730:Endothelium, Vascular / Q000502:physiology* / Q000528:radiation effects / Q000601:surgery; D005720:Gamma Rays; D008297:Male; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000502:physiology*
D003037:Cobalt Radioisotopes
Reparativnaia regeneratsiia éndoteliia aorty krysy pri mikrokhirurgicheskikh vmeshatel'stvakh na fone lokal'nogo gamma-oblucheniia (po dannym skaniruiushcheĭ élektronnoĭ mikroskopii.