[Long-term experiences with moxonidine, a new antihypertensive agent].
Monoxidine is a new antihypertensive agent that, as pharmacological studies show, reduces blood pressure by stimulating central presynaptic alpha-2-receptors. In this open multicenter trial, 141 ambulatory hypertensives were treated for 12 months with monoxidine. After a run-in placebo period the mean supine blood pressure was 172.7 +/- 15.0/103.2 +/- 6.0 mmHg. After an individual dose-adjustment phase of 3 weeks starting from a daily dose of 0.2 mg monoxidine, the mean blood pressure decreased to 150.7 +/- 13.4/87.5 +/- 5.5 mmHg. In 96 patients, the blood pressure reduction was achieved within 3 weeks at a dose of 0.2 mg, while 52 patients required a dose of 0.4 mg. Over the 12-month treatment period, no tolerance to the drug developed. In 137/141 cases (97%), the drug was well or very well tolerated. At the state of treatment dryness of mouth was observed in 12.9% and lassitude in 4.8%. On discontinuation of monoxidine, blood pressure gradually increased. All in all, monoxidine proved to be well tolerated, reliable and safe in the long-term treatment of hypertension.
Schwarz
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W
Kandziora
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007093:Imidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D007093:Imidazoles; C043482:moxonidine
Langzeiterfahrungen mit Moxonidin, einem neuen Antihypertensivum.