A recombination map of the human X-chromosome.
A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-overs that have occurred in the p and q arms; (c) not shown any cross-overs in the centromeric region and (d) enabled the calculation of the genetic length of the X-chromosome.
Del Mastro
R G
RG
Department of Clinical Genetics, Birmingham Maternity Hospital, University of Birmingham, UK.
Farndon
P A
PA
Kilpatrick
M W
MW
D002871:Chromosome Banding; D002874:Chromosome Mapping; D015342:DNA Probes; D005260:Female; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D014960:X Chromosome
D015342:DNA Probes