Does combined kidney and pancreas transplantation reverse functional diabetic microangiopathy?
Using videophotometric capillaroscopy and laser Doppler fluxmetry, we have investigated skin microvascular reactivity in the fingers of 14 diabetic patients with severe, late complications 20 months after combined kidney and pancreas transplantation. The results were compared with those obtained in 20 diabetic patients awaiting pancreas transplantation and in 19 healthy subjects. The capillary blood cell velocity at rest (P less than 0.01) and during postocclusive reactive hyperemia (P less than 0.05) was significantly lower in both patient groups than in the healthy controls. However, the time to peak capillary blood cell velocity during hyperemia was normal in the post-transplantation group (NS) but significantly prolonged in the pretransplantation group (P less than 0.01). The ability to decrease flow during venous stasis-the so called venoarte-riolar reflex--was strongly impaired in the pretransplantation group (P less than 0.001) but less so in the post-transplantation group (P less than 0.05) as compared to healthy controls. It may be concluded that diabetic patients, after combined kidney and pancreas transplantation, show a tendency towards better microvascular reactivity than those awaiting transplantation.
Jörneskog
G
G
Department of Internal Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Ostergren
J
J
Tydén
G
G
Bolinder
J
J
Fagrell
B
B
D000328:Adult; D001783:Blood Flow Velocity; D002196:Capillaries / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D016030:Kidney Transplantation; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D016035:Pancreas Transplantation; D012867:Skin / Q000098:blood supply*