[The effect of estradiol and reserpine on cortisol formation in sexually immature rats].
The studies were carried out on immature female rats. The animals were divided into 4 groups: 1) treated with saline, 2) treated with reserpine, 3) treated with estradiol and 4) treated with estradiol and reserpine. Administration of drugs were made on 35, 36 and 37 day after delivery. There was statistically significant difference between the control group, treated with saline, and the group of rats, treated with estradiol. This is a new original fact for the presence of estrogen receptors in adrenal cells. Significant difference was found between the groups, treated with reserpine, and those, treated with saline and estradiol. The presented new data support the concept on the role of the adrenergic system in inhibiting hypothalamo-hypophysial-adrenal axis.
Vlasova
D
D
Borisova
I
I
Kŭnchev
L
L
D000375:Aging / Q000097:blood / Q000187:drug effects; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D012741:Sexual Maturation / Q000187:drug effects*
D004958:Estradiol; D012110:Reserpine; D006854:Hydrocortisone
Efekt na estradiol i rezerpin vŭrkhu obrazuvaneto na kortizol u polovo nezreli plŭkhove.