title: Bleeding time is prolonged during oral anticoagulant therapy.
abstract: We have performed the BT test in 55 patients undergoing oral anticoagulant therapy monitored by means of Thrombotest (TT). Patients in steady state of anticoagulation showed longer BT than normal controls; patients in overdose phase had longer BT values than either controls or patients in steady state. After recovery the overdose phase patients showed BT values not different from those of the controls. Moreover we were able to find in our patients a significant linear correlation between BT and TT. Impairment in primary haemostasis could be due either to a scarce fibrin deposition in the haemostatic plug or to deficiency of a possible vitamin K dependent vascular "bleeding factor".
authors: Istituto di Medicina Interna, Università di Cagliari, Italy.
authors: F
authors: F
authors: Marongiu
authors: G
authors: G
authors: Biondi
authors: G G
authors: GG
authors: Sorano
authors: G
authors: G
authors: Mameli
authors: M
authors: M
authors: Conti
authors: A M
authors: AM
authors: Mamusa
authors: M C
authors: MC
authors: Cadoni
authors: A
authors: A
authors: Balestrieri
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D001760:Bleeding Time; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D000925:Anticoagulants