[Bone complications from chronic etretinate intoxication in children].
Clinical, roentgenographic and biologic features of etretinate bone toxicity in a 13-year-old girl with pachyonychia congenita syndrome are reported. Etretinate is a synthetic derivative of vitamin A that infrequently induces bone and joint abnormalities in children. The following manifestations can be observed: cortical hyperostosis, pain, calcification of tendons, thinning of long bones, demineralization, premature closure of epiphyses, or abnormal remodelling. Onset of these anomalies is often delayed since etretinate has a long half-life. Mechanisms are unknown. We advocate use of the minimum effective dosage and regular monitoring of patients.
Cointin
M
M
Centre de Convalescence Pédiatrique St Lambert-Lioux, Gordes.
Sommelet-Olive
D
D
Cuny
J F
JF
Bretagne
M C
MC
D000293:Adolescent; D001847:Bone Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D005050:Etretinate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009260:Nail Diseases / Q000151:congenital / Q000188:drug therapy*; D011859:Radiography
D005050:Etretinate
Complications osseuses de l'intoxication chronique par l'étrétinate chez l'enfant.