Application of structural model of glucose-insulin relations to assess beta-cell function and insulin sensitivity.
A structural mathematical model of glucose-insulin relationships based on known quantitative responses of the major organs involved with glucose metabolism has been computed. Different degrees of beta-cell function and insulin sensitivity can be included, and the effect of their interaction assessed (i) in a steady state, basal homeostasis after an overnight fast and (ii) in response to a glucose infusion. By comparing a patient's basal plasma glucose and insulin (or C-peptide) concentrations with the predictions of a basal homeostatic model, the degree of impairment of beta-cell function and insulin sensitivity can be assessed. Similarly, the plasma glucose and insulin (or C-peptide) concentrations after a continuous glucose infusion can also be compared with predictions from the model to estimate beta-cell function and insulin sensitivity. These assessments of pathophysiology can be applied to data from individual patients or to patient populations.
Turner
R C
RC
Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, United Kingdom.
Rudenski
A S
AS
Matthews
D R
DR
Levy
J C
JC
O'Rahilly
S P
SP
Hosker
J P
JP
D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005947:Glucose