The lack of relationship between acetylator phenotype and idiopathic systemic lupus erythematosus in a South-east Asian population: a study of Indians, Malays and Malaysian Chinese.
An association of idiopathic systemic lupus erythematosus (ISLE) with genetically determined N-acetylation polymorphism has been suspected from previous studies, mainly on Caucasian populations in which there is an approximate incidence of 50% of slow and rapid acetylators. The present study is of the incidence of ISLE and acetylator status in a mixed population of Malaysia. The results did not support an association between ISLE and acetylator status: the frequencies of slow acetylators in the ISLE patients who were Malaysian Chinese and Malay were 13 and 38% respectively. This did not differ significantly from the respective healthy groups (20 and 29%). The small number of Indians in the survey did not allow a valid comparison, but the figures did suggest a lack of association between ISLE and acetylator status.
Ong
M L
ML
Guy's Hospital, London.
Mant
T G
TG
Veerapen
K
K
Fitzgerald
D
D
Wang
F
F
Manivasagar
M
M
Bosco
J J
JJ
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D001210:Asia, Southeastern / Q000453:epidemiology; D002681:China / Q000208:ethnology; D003622:Dapsone; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics* / Q000382:microbiology; D008296:Malaysia / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013997:Time Factors
D003622:Dapsone