[Correlation between IGA from colostrum and serum and IGA is closer than between salivary IGA and total IGA].
Colostrum, serum and saliva were simultaneously obtained from 50 normal mothers. 19-45 years old, 36-72 hours post-delivery. Total IgA level and class-IgA antibodies against 3 common food antigens (lactoglobulin, gliadin and ovalbumin) and 4 types of salmonella (typhi, paratyphi A, B and C) were determined in all samples. The 7 antibodies (Ab) were detected in colostrum, by ELISA, in a higher percentage of samples (88-62%), than in serum (82-34%) and saliva (77-27%). These percentages were higher for food-Ab than for anti-salmonella Ab. The total colostral IgA was close correlated with food-Ab in colostrum (p less than 0.001) and quite poorer with anti-salmonella Ab (p less than 0.05-p less than 0.01). A good correlation was generally also present between Ab from colostrum/serum, but was worse between both secretions (colostrum/saliva). The present results suggest that colostrum specific Ab levels can be predicted, depending on total IgA and the specific Ab from serum.
Tallería Orriols
J J
JJ
Cátedra de Pediatría, Facultad de Medicina de Valladolid.
Blanco Quirós
A
A
Gómez Carrasco
J A
JA
Díez Fernández
T
T
Garrido
M
M
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D003126:Colostrum / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D049590:Postpartum Period / Q000276:immunology*; D011247:Pregnancy; D012463:Saliva / Q000276:immunology*; D012475:Salmonella / Q000276:immunology
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A
Mejor relación de los anticuerpos-IgA calostrales con la IgA total y con los anticuerpos séricos que con los salivares.