title: [Endodermal sinus tumor. Histological changes induced by chemotherapy].
abstract: The case of a child affected at birth sacrococcygeal teratoma is reported. Twenty-eight months following surgical resection, the tumor relapsed locally and liver metastases occurred. A biopsy of the sacrococcygeal mass was performed and histologic examination proved it to be an endodermal sinus (yolk sac) tumor. Chemotherapy consisting of etoposide and high-dose carboplatin was started. When a second operation was performed the mass had disappeared and the macroscopically involved areas of liver were removed. Histologic examination demonstrated that the complete necrosis of the tumor was partially replaced by a fibrous scar tissue. The child underwent adjuvant chemotherapy and now is in complete remission fourteen months after the last operation.
authors: Istituto di Clinica Pediatrica, Università degli Studi La Sapienza, Roma.
authors: C
authors: C
authors: Dominici
authors: C
authors: C
authors: Bosman
authors: S
authors: S
authors: De Sanctis
authors: A
authors: A
authors: Clerico
authors: M F
authors: MF
authors: Thorel
authors: A
authors: A
authors: Ceccamea
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage*; D005047:Etoposide / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008649:Mesonephroma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D012445:Sacrococcygeal Region; D013724:Teratoma / Q000556:secondary / Q000601:surgery; D013997:Time Factors
chemical_list: D005047:Etoposide; D016190:Carboplatin
vernacular_title: Tumore del seno entodermico. Modificazioni istologiche indotte dalla chemioterapia.