title: Prolactin response to low-dose haloperidol challenge in schizophrenic, non-schizophrenic psychotic, and control subjects.
abstract: Haloperidol was administered IV to 46 male psychotic inpatients and 28 male control subjects. A two-way analysis of covariance, with age as the covariate, revealed that DSM-III schizophrenics (n = 27) had a lower prolactin response to haloperidol than did the controls (n = 28). There were no significant differences between the prolactin responses in schizophrenics, patients with affective disorders (n = 7), and those with other psychoses (n = 12), which included patients with paranoia, schizophreniform, schizoaffective disorder, and atypical psychoses. These findings support the proposition that tuberoinfundibular dopaminergic dysfunction may occur in certain patients with DSM-III schizophrenia.
authors: National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria.
authors: D L
authors: DL
authors: Copolov
authors: N A
authors: NA
authors: Keks
authors: J
authors: J
authors: Kulkarni
authors: B S
authors: BS
authors: Singh
authors: D
authors: D
authors: McKenzie
authors: P
authors: P
authors: McGorry
authors: C
authors: C
authors: Hill
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000097:blood; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood*; D012559:Schizophrenia / Q000097:blood*
chemical_list: D011388:Prolactin; D006220:Haloperidol