title: Post heparin lipoprotein lipase activity in patients of ischaemic heart disease and in controls.
abstract: A single high fat meal diet (66 gm fat) was given to 30 healthy males and 20 male patients of ischaemic heart disease (IHD). Ten minutes prior to the 4th postprandial hour, 500 units of heparin--a lipoprotein lipase (LPL) activator--was given, and its effect seen on serum triglyceride (STG) levels observed. Besides higher fasting STG levels, the decline in 4 hour post-prandial STG level was significantly lower in patients of IHD. One explanation for higher fasting STG values and prolonged postprandial lipaemia in these subjects could be deficient LPL activity.
authors: Dept. of Medicine, MLB Medical College, Jhansi, India.
authors: R C
authors: RC
authors: Arora
authors: N
authors: N
authors: Agarwal
authors: S
authors: S
authors: Arora
authors: N
authors: N
authors: Kumar
authors: S
authors: S
authors: Lakhtakia
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000097:blood*; D004041:Dietary Fats / Q000008:administration & dosage; D004789:Enzyme Activation / Q000187:drug effects; D005069:Evaluation Studies as Topic; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D014280:Triglycerides; D006493:Heparin; D008071:Lipoprotein Lipase