title: Scleroderma esophagus.
abstract: Scleroderma (systemic sclerosis) is a connective tissue disorder characterized by thickening and fibrosis of the skin and visceral involvement that may include the heart, lungs, kidneys, and gastrointestinal tract. At least 40-50% of patients with scleroderma experience esophageal symptoms such as heartburn and dysphagia, while up to 90% of patients have esophageal dysfunction on objective testing at some point in their disease. The disease results in smooth muscle dysfunction that causes esophageal aperistalsis and reduced lower esophageal sphincter pressures. Gastroesophageal reflux with poor acid clearance results with an increased incidence of complications such as peptic stricture and Barrett's esophagus. Aggressive medical therapy is necessary to prevent these and other complications of gastroesophageal reflux.
authors: Bowman Gray School of Medicine, Winston-Salem, North Carolina.
authors: S R
authors: SR
authors: Fulp
authors: D O
authors: DO
authors: Castell
mesh_terms: D004935:Esophageal Diseases / Q000175:diagnosis; D004940:Esophageal Stenosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D010528:Peristalsis; D012595:Scleroderma, Systemic / Q000175:diagnosis