title: [Synthesis and biological activity of aminophenylphosphonic derivatives of levorin].
abstract: Reactions of levorin, a polyenic macrolide antibiotic, with aromatic aldehydes and hypophosphorous acid resulted in formation of its amino phenylphosphonium derivatives. Physicochemical and biological properties of the derivatives were studied. The levorin amino phenylphosphonium derivatives were shown to be low toxic and have antifungal and antiviral activities.
authors: V V
authors: VV
authors: Belakhov
authors: A A
authors: AA
authors: Levina
authors: Iu D
authors: IuD
authors: Shenin
authors: B I
authors: BI
authors: Ionin
authors: L I
authors: LI
authors: Shatik
authors: M B
authors: MB
authors: Zaĭtseva
authors: G E
authors: GE
authors: Grinberg
authors: E B
authors: EB
authors: Shtil'bans
authors: L A
authors: LA
authors: Rachkovskaia
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D002174:Candicidin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005658:Fungi / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D014777:Virus Diseases / Q000188:drug therapy* / Q000382:microbiology; D014780:Viruses / Q000187:drug effects*
chemical_list: D000447:Aldehydes; D000588:Amines; D063065:Organophosphonates; D002174:Candicidin
vernacular_title: Poluchenie i biologicheskaia aktivnost' aminofenilfosfonistykh proizvodnykh levorina.