title: Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.
abstract: Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).
authors: CNRS-URA 1332, Neurobiologie des fonctions rythmiques et saisonnières, Université Louis Pasteur, Strasbourg, France.
authors: D J
authors: DJ
authors: Skene
authors: B
authors: B
authors: Vivien-Roels
authors: D L
authors: DL
authors: Sparks
authors: J C
authors: JC
authors: Hunsaker
authors: P
authors: P
authors: Pévet
authors: D
authors: D
authors: Ravid
authors: D F
authors: DF
authors: Swaab
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008875:Middle Aged; D009994:Osmolar Concentration; D010870:Pineal Gland / Q000378:metabolism*; D011863:Radioimmunoassay; D012727:Sex Characteristics
chemical_list: D007211:Indoles; C002465:methoxytryptophol; D008550:Melatonin