[Application of 13C label-nuclear magnetic resonance (NMR) tracer techniques to clinical chemistry. Metabolic rate of benzoic acid to hippuric acid].
A new tracer technique, in which a 13C-labeled compound as a biological tracer and 13C nuclear magnetic resonance (NMR) as an analytical tool are used, is proposed. In order to verify the applicability of the method to clinical chemistry. [1-13C]benzoic acid was administered and [1'-13C]hippuric acid excreted in the urine was quantitated by NMR, by using [1-13C]hippuric acid as an internal standard.
Baba
S
S
Tokyo College of Pharmacy, Japan.
Akira
K
K
Sakuma
C
C
D001565:Benzoates / Q000493:pharmacokinetics*; D019817:Benzoic Acid; D002247:Carbon Isotopes; D006626:Hippurates / Q000652:urine*; D006801:Humans; D008658:Inactivation, Metabolic; D009682:Magnetic Resonance Spectroscopy
D001565:Benzoates; D002247:Carbon Isotopes; D006626:Hippurates; D019817:Benzoic Acid; C030514:hippuric acid