title: [Familial cases of cutaneous myxomas and spotty pigmentation (Carney's complex)].
abstract: In 1985, Carney et al reported a complex of myxomas, spotty pigmentation, and endocrine overactivity and subsequently demonstrated dominant inheritance of the condition. The criteria for diagnosis of the complex is the presence of two or more of the following conditions: (1) cardiac myxoma, (2) cutaneous myxoma, (3) mammary myxoma, (4) spotty mucocutaneous pigmentation, (5) primary pigmented nodular adrenocortical disease (Cushing's syndrome), (6) testicular tumors (sexual precocity), (7) pituitary adenoma secreting growth hormone (acromegaly or gigantism). We encountered a family with an affected mother and daughter. Case 1 was a 43-year-old woman with multiple cutaneous myxomas, mammary myxomas and spotty mucocutaneous pigmentation. Case 2, the 19-year-old daughter of case 1 had multiple cutaneous myxomas and spotty cutaneous pigmentation. These two cases both met the criteria for the diagnosis of the complex. Our report is believed to be the first report on the complex in Japan.
authors: Department of Dermatology, School of Medicine, Tokyo Medical and Dental University.
authors: T
authors: T
authors: Koyano
authors: T
authors: T
authors: Satoh
authors: N
authors: N
authors: Ohtaki
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D003480:Cushing Syndrome / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D009232:Myxoma / Q000235:genetics* / Q000473:pathology; D010859:Pigmentation Disorders / Q000235:genetics / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology