[The role of oxygen in the inhibition of Escherichia coli respiration by copper ions].
Effect of Cu2+ on E. coli respiration and the role of oxygen in toxic action of copper has been studied. Stimulation of respiration is observed at initial time after introduction of Cu2+. It is based on a nonspecific cell response to membrane damage. After finishing of transitory processes, Cu2+ influenced respiration by noncompetitive inhibition, i.e. copper-sensitive enzyme can be oxygenated or nonoxygenated, and only the latter form of the enzyme is inhibited.
Lebedev
V S
VS
Veselovskiĭ
A V
AV
Fedorov
Iu I
IuI
D003300:Copper / Q000633:toxicity*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000493:pharmacokinetics*; D010313:Partial Pressure
D003300:Copper; C029892:cupric chloride; D010100:Oxygen
Rol' kisloroda v ingibirovanii dykhaniia Escherichia coli ionami medi.