Abnormalities of central motor conduction in asymptomatic HIV-positive patients. Significance and prognostic value.
Percutaneous magnetic stimulation of the brain and spinal cord is a technique developed to demonstrate early and subclinical abnormalities in corticomotoneuron pathways. Central motor conduction time (CMCT) was evaluated in 58 HIV-seropositive patients neurologically asymptomatic (CDC groups II and III) and in two control groups. CMCT was abnormal in about 50% of HIV-seropositive patients. These electrophysiological abnormalities seem to have a negative prognostic value since about 64% of the patients with abnormal parameters seem to progress more rapidly to AIDS stages.
Zandrini
C
C
Dept. of Clinical Neurophysiology, IRCCS C. Mondino, Italy.
Ciano
C
C
Alfonsi
E
E
Sandrini
G
G
Minoli
L
L
Moglia
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D000200:Action Potentials; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009431:Neural Conduction