Deletion analysis of male sterility effects of t-haplotypes in the mouse.
We present data on the effects of three chromosome 17 deletions on transmission ratio distortion (TRD) and sterility of several t-haplotypes. All three deletions have similar effects on male TRD: that is, Tdel/tcomplete genotypes all transmit their t-haplotype in very high proportion. However, each deletion has different effects on sterility of heterozygous males, with TOr/t being fertile, Thp/t less fertile, and TOrl/t still less fertile. These data suggest that wild-type genes on chromosomes homologous to t-haplotypes can be important regulators of both TRD and fertility in males, and that the wild-type genes concerned with TRD and fertility are at least to some extent different. The data also provide a rough map of the positions of these genes.
Bennett
D
D
Department of Zoology, University of Texas, Austin 78712-1064.
Artzt
K
K
D000818:Animals; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D005260:Female; D005838:Genotype; D006239:Haplotypes; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D051379:Mice