Insulin-mimicking anti-idiotypic antibodies in development of spontaneous autoimmune diabetes in BB/E rats.
BB/E rats spontaneously develop a form of autoimmune diabetes resembling insulin-dependent diabetes mellitus (IDDM) in humans. IDDM results from central destruction of the insulin-producing beta-cells of the pancreatic islets. Herein, we report that the outbreak of IDDM in BB/E rats is preceded by the spontaneous development of an anti-idiotypic antibody to a particular antibody to insulin made by the rats. This anti-idiotype, designated anti-DM-id, behaves as an antibody to the insulin-hormone receptor. Thus, a spontaneous anti-idiotypic antibody network whose products can affect the peripheral utilization of insulin seems to accompany the central destruction of beta-cells in developing IDDM.
Elias
D
D
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Bone
A J
AJ
Baird
J D
JD
Cooke
A
A
Cohen
I R
IR
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology / Q000502:physiology*; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D007328:Insulin / Q000097:blood / Q000276:immunology / Q000502:physiology*; D007330:Insulin Antibodies / Q000276:immunology; D051381:Rats; D011913:Rats, Inbred BB / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007328:Insulin; D007330:Insulin Antibodies