Pharmacokinetics of midazolam in critically ill neonates.
Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children. An IV bolus of midazolam 0.2 mg.kg-1 was administered to 10 critically ill neonates receiving intensive care who required sedation. The plasma clearance was 6.85 ml.min-1 and the elimination half-life was 6.52 h. Midazolam was well tolerated during and after administration. Because of its short half-life compared to diazepam, midazolam could be used during the neonatal period to produce brief rapid sedation.
Jacqz-Aigrain
E
E
Unité de Pharmacologie Clinique Hôpital Robert Debré, Paris, France.
Wood
C
C
Robieux
I
I
D002851:Chromatography, High Pressure Liquid; D003422:Critical Care; D003975:Diazepam / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000378:metabolism*; D008874:Midazolam / Q000493:pharmacokinetics*; D012127:Respiratory Distress Syndrome, Newborn / Q000378:metabolism
D003975:Diazepam; D008874:Midazolam