title: The pharmacological and pathological studies on Taiwan folk medicine (III): The effects of bupleurum kaoi and cultivated bupleurum falcatum var. komarowi.
abstract: The protective effects of water extract from roots of Bupleurum kaoi Liu, Chao et Chuang and Bupleurum flacatum L. var. Komarowi Koso-Polj on CCl4-induced hepatoxicity have been investigated. Both B. kaoi (p less than 0.05) and B. falcatum var. komarowi (p less than 0.01) possessed more marked anti-hepatotoxic pharmacological effects than Bupleurum chinense DC., the typical strain widely used in Taiwan. The pathological improvement from treatment by means of the three drugs to alleviate CCl4-induced hepatic toxicity was estimated using morphological changes of hepatocytes, reduction of inflammatory cells infiltration and liver function tests.
authors: School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
authors: C C
authors: CC
authors: Lin
authors: H F
authors: HF
authors: Chiu
authors: M H
authors: MH
authors: Yen
authors: C C
authors: CC
authors: Wu
authors: M F
authors: MF
authors: Chen
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008107:Liver Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013624:Taiwan
chemical_list: D001798:Blood Proteins; D004365:Drugs, Chinese Herbal; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin