Late effects of total body irradiation and cytostatic preparative regimen for bone marrow transplantation in children with hematological malignancies.
Twenty-seven children, surviving disease-free for more than 1 year after allogeneic bone marrow transplantation (BMT) for hematological malignancy were evaluated for the long-term effects on endocrine function, sexual development, physical growth, appearance of ocular cataract and psychological sequelae. The growth rate was not decelerated in the prepubertal period in children not affected by chronic graft-versus-host (GVH) disease and without previous cranial irradiation. Development of sexual characteristics was delayed in 4 relevant cases. Thyroid function was not adversely affected, gonadal function was impaired in girls, transplanted after menarche, ocular cataract developed in all cases, irradiated without shielding of the eyes after 4 years. Psychologically, children after BMT had an advantageous social development.
van Weel-Sipman
M H
MH
Department of Pediatrics, University Hospital Leiden, The Netherlands.
van't Veer-Korthof
E T
ET
van den Berg
H
H
Gerritsen
E J
EJ
Noordijk
E M
EM
Kamphuis
R P
RP
Vossen
J M
JM
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D011627:Puberty / Q000528:radiation effects; D012917:Social Adjustment; D013959:Thyroid Diseases / Q000209:etiology; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects*