Methapyrilene: DNA as a possible target.
The structural features contributing to the potential carcinogenicity, DNA-reactivity and genotoxicity of methapyrilene and its non-carcinogenic congener pyrilamine were examined. The analyses suggest that the former has the potential for DNA-reactivity, a property which is absent from the latter.
Rosenkranz
H S
HS
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Klopman
G
G
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004249:DNA Damage; D008701:Methapyrilene / Q000633:toxicity*; D051379:Mice; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens; D011738:Pyrilamine / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009153:Mutagens; D008701:Methapyrilene; D011738:Pyrilamine