Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein.
Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.
Borton
M
M
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
Neligan
M
M
Wood
F
F
Dervan
P
P
Goggins
K
K
Docherty
J R
JR
D003331:Coronary Vessels / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007537:Isometric Contraction; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012501:Saphenous Vein / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin