[Cytogenetic study in multiple myeloma. II. Clinical significance of chromosomal changes].
The authors evaluated in a group of 56 patients with multiple myeloma the clinical impact of assessed chromosomal changes. They found a close relationship between the frequency of chromosomal deviations and the extent and activity of the disease. The authors did not detect a relationship between the frequency of karyotypic changes and the number of plasmocytes in bone marrow nor a significant difference in the incidence of hypodiploidy in different immunochemical types of multiple myeloma. Patients with chromosomal changes had a reduced response to cytostatic treatment. The authors revealed a prognostic importance of chromosomal changes, in particular of hyperdiploidy and the concurrent incidence of numerical and structural deviations. The authors discuss the relationship of monosomia of the X chromosome and the Y chromosome to the clinical picture of the disease and chromosomal findings in secondary myeloblastic leukaemia, myelodysplastic syndrome and secondary plasmocellular leukaemia.
Scudla
V
V
III Vnitrní klinika lékarské fakulty Univerzity Palackého, Olomouc.
Jarosová
M
M
Kapustová
M
M
Indrák
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011379:Prognosis
Cytogenetické vysetrení u mnohotného myelomu. II. Klinický význam chromozomálních zmĕn.