Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization.
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of catarrhines, platyrrhines, and prosimians. By this approach rearrangements of chromosomes that occurred during hominoid evolution are visualized directly at the level of DNA sequences, even in primate species with pronounced chromosomal shuffles.
Wienberg
J
J
Institut für Anthropologie und Humangenetik, Universität München, Federal Republic of Germany.
Jauch
A
A
Stanyon
R
R
Cremer
T
T
D000818:Animals; D002877:Chromosomes, Human; D004247:DNA / Q000235:genetics; D015698:Genomic Library; D015186:Hominidae / Q000235:genetics; D006801:Humans; D009693:Nucleic Acid Hybridization; D010802:Phylogeny; D011323:Primates / Q000145:classification* / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D004247:DNA