[Concentrations of A. actinomycetemcomitans in subgingival plaque following short-term minocycline therapy].
In the present study we examined alterations in the proportions of cultivable flora of A. actinomycetemcomitans (A.a.) in subgingival plaque of 25 patients with different forms of periodontitis, 7 days after systemic administration of 200 mg/d Minocycline-HCl. Remarkable shifts in the flora were apparent. Sites with low or extremely low initial levels of A.a. (less than 10%) showed an increase in mean proportions from 2.7% to 15.7% (p less than 0.01). A.a. was eliminated in only 18% of sites after 1 week of minocycline therapy. Subgingival scaling resulted in 80% of sites without detectable A.a. However, if present, the organism accounted for 51% of the cultivable microflora, on average. Our data emphasize the importance of a sufficiently extended period of antibiotic therapy and efficient mechanical debridement of all tooth surfaces to eliminate the organism.
Müller
H P
HP
Zentrum für Zahn-, Mund- und Kieferkrankheiten der Westfalischen Wilhelms-Universität Munster.
Lange
D E
DE
Müller
R F
RF
D000188:Actinobacillus / Q000302:isolation & purification*; D000704:Analysis of Variance; D003773:Dental Plaque / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology*
D008911:Minocycline
Konzentrierung von A. actinomycetemcomitans in subgingivaler Plaque nach kurzfirstiger Minocyclin-Therapie.