Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells.
pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.
Charles
C H
CH
Department of Genetics, University of Illinois College of Medicine, Chicago 60612.
Simske
J S
JS
O'Brien
T P
TP
Lau
L F
LF
D000310:Adrenal Gland Neoplasms; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000235:genetics; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D015723:Gene Library; D006133:Growth Substances / Q000494:pharmacology*; D006207:Half-Life; D017874:Immediate-Early Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010452:Peptide Biosynthesis; D010455:Peptides / Q000235:genetics* / Q000378:metabolism; D010673:Pheochromocytoma; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D055232:Proline-Rich Protein Domains; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D006133:Growth Substances; D017874:Immediate-Early Proteins; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D012333:RNA, Messenger; C484022:pip92 protein, rat; C066505:Ier2 protein, mouse; D005346:Fibroblast Growth Factors; D004247:DNA; D013755:Tetradecanoylphorbol Acetate