[5-Fluorouracil and trabeculectomy. A trial of low doses].
Postoperative subconjonctival 5-Fluorouracil (5 FU) may enhance the surgical outcome of trabeculectomies in eyes at high risk of operative failure. 23 patients who received postoperative low doses of subconjonctival 5 Fluorouracil (5 FU) have been studied with a mean follow-up of 10 months. Our indications were: risk factors for a trabeculectomy; postoperative pressure remaining high or absence of filtering bleb. The results were: 42% of complete success (IOP less than 21 mmHg without addition therapy); 29% of qualified success (IOP less than 25 mmHg with additional therapy, or 21 mmHg less than IOP less than 25 mmHg without therapy); 29% of failure. The most frequent complications are corneal, but healed within a short period. The efficacity of the drug remains even with low doses, and with less complications.
Adenis
J P
JP
Service d'ophtalmologie, CHU Dupuytren, Limoges.
Duprat
F
F
D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D014130:Trabeculectomy / Q000009:adverse effects
D005472:Fluorouracil
5 Fluoro-uracile et trabéculectomies: essai d'utilisation à doses faibles.