Embedded or not? Hydrophobic sequences and membranes.
The same translocation machinery appears to be responsible for both the translocation of soluble proteins across membranes and the insertion of integral membrane proteins into the bilayer. A single mechanism is proposed to accommodate these two functions. This model is also extended to explain the paradoxical translocation of mitochondrial and chloroplastic membrane proteins across one or more membranes before they are finally inserted into their target membranes.
Singer
S J
SJ
Department of Biology, University of California, San Diego, La Jolla 92093.
Yaffe
M P
MP
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000378:metabolism; D002736:Chloroplasts / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D012995:Solubility
D002352:Carrier Proteins; D008565:Membrane Proteins