Amniotic fluid catecholamine metabolites in maternal smoking.
The concentration of dopamine (DA), norepinephrine (NE), and its metabolites 3-methoxy-4-hydroxy-phenylethylene glycol (MHPG) and vanillyl mandelic acid (VMA), and prostaglandins E2, and F2a in amniotic fluid were measured at labor (1-3 cm of cervical dilatation), in uncomplicated and complicated pregnancies. The amniotic fluid concentration (mean +/- SD) of MHPG in maternal smoking (S) (30.6 +/- 11.9 nmol.mg creatinine-1) and intrauterine growth retardation (IUGR) (36.7 +/- 15.2 nmol.mg creatinine-1) groups is significantly higher than in uncomplicated pregnancies (C) (22.9 +/- 8.8 nmol.mg creatinine-1), or diabetes mellitus groups (D) (26.1 +/- 10.9 nmol.mg creatinine-1) groups; VMA presents similar differences between groups S (145.8 +/- 84.4 nmol.mg creatinine-1) and IUGR (173.0 +/- 135.4 nmol.mg creatinine-1) higher than C (58.3 +/- 26.1 nmol.mg creatinine-1) and D (76.8 +/- 49.0 nmol.mg creatinine-1) groups. NE levels differ between groups in a similar way, but DA does not present significant differences between groups. Prostaglandin levels are higher in the S than in the C group. Nicotine action and/or hypoxia are proposed as a possible cause of NE, MHPG, and VMA rise in amniotic fluid of S, and IUGR versus C or D groups.
Suarez
A
A
Departamento de Cirugía y Medicina Experimental, Hospital General Gregorio Marañón, Madrid, España.
Rico
F
F
Clavero-Nuñez
J A
JA
Garcia-Barreno
P
P
D000653:Amniotic Fluid / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D036861:Delivery, Obstetric; D004298:Dopamine / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis; D011247:Pregnancy / Q000378:metabolism*; D011248:Pregnancy Complications / Q000378:metabolism*; D011254:Pregnancy in Diabetics / Q000378:metabolism; D012907:Smoking / Q000378:metabolism*; D014642:Vanilmandelic Acid / Q000032:analysis*
D008734:Methoxyhydroxyphenylglycol; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine