Recovery of morphine from a controlled-release preparation. A source of opioid abuse.
MS-Contin (Purdue-Fredrick, Norwalk, CT) is a controlled-release preparation of morphine sulfate that has demonstrated efficacy in the management of chronic cancer pain problems. It has recently come to the attention of the authors that MS-Contin represents a potential source of opioid abuse through the extraction and intravenous injection of the morphine from this preparation. The authors describe a simple aqueous extraction method that was used to quantitatively determine the extent to which morphine could be obtained from MS-Contin tablets.
Crews
J C
JC
Department of Anesthesia, University of Cincinnati College of Medicine, Ohio.
Denson
D D
DD
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D008722:Methods; D009020:Morphine / Q000008:administration & dosage* / Q000302:isolation & purification*; D015819:Substance Abuse, Intravenous
D003692:Delayed-Action Preparations; D009020:Morphine