Antianoxic action and active constituents of atractylodis lanceae rhizoma.
The screening test was carried out to identify new drugs from natural products for the KCN-induced anoxia model in mice. Acetone extract of Atractylodis Lanceae Rhizoma (Atractylodes lancea DC. var. Chinensis Kitamura) had a significant effect in the KCN-induced anoxia model and therefore the extract was selected for further study in order to identify the active principles. The result showed that beta-eudesmol was the active component in Atractylodis Lanceae Rhizoma.
Yamahara
J
J
Kyoto Pharmaceutical University, Japan.
Matsuda
H
H
Naitoh
Y
Y
Fujimura
H
H
Tamai
Y
Y
D000818:Animals; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology*; D011190:Potassium Cyanide
D010936:Plant Extracts; D011190:Potassium Cyanide