Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
Omeprazole, a gastric mucosal proton pump inhibitor, significantly and dose-dependently prevented the delayed healing of acetic acid-induced gastric ulcers in response to repeatedly administered indomethacin to rats. Both basal and histamine-stimulated gastric acid secretions in rats with acetic acid-induced ulcers that were given indomethacin were markedly and persistently (greater than 24 hr) inhibited after 4 weeks treatment with omeprazole. The prevention of delayed ulcer healing by omeprazole appears to be due to its long-lasting antisecretory activity.
Wang
J Y
JY
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Nagai
H
H
Okabe
S
S
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D004359:Drug Therapy, Combination; D005744:Gastric Acid / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000085:Acetates; D006632:Histamine; D009853:Omeprazole; D019342:Acetic Acid; D007213:Indomethacin