title: Kynurenic acid synthesis by human glioma.
abstract: Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 microM L-kynurenine, the immediate bioprecursor of KYNA, freshly prepared tissue slices in a dose-dependent fashion produced KYNA which was detected in the incubation medium. De novo synthesized KYNA was identified by several chromatographic procedures. Astrocytomas produced significantly more KYNA than glioblastomas.
authors: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors: A
authors: A
authors: Vezzani
authors: J B
authors: JB
authors: Gramsbergen
authors: P
authors: P
authors: Versari
authors: M A
authors: MA
authors: Stasi
authors: F
authors: F
authors: Procaccio
authors: R
authors: R
authors: Schwarcz
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007736:Kynurenic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D007736:Kynurenic Acid