LDL-cholesterol as a determinant of coronary heart disease.
The Adult Treatment Panel of the National Cholesterol Education Program identified high levels of LDL-cholesterol as a major risk factor in developing CHD and as the primary target for cholesterol-lowering therapy. Low levels of HDL were recognized as a contributing risk factor for CHD, and the panel recommended that low HDL-cholesterol levels be raised by changes in diet and lifestyle. When drug therapy is required for high LDL-cholesterol levels in the presence of low HDL levels, it would appear reasonable to choose one that both markedly reduces LDL-cholesterol and raises HDL-cholesterol.
Hunninghake
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Heart Disease Prevention Clinic, University of Minnesota.
D000818:Animals; D008076:Cholesterol, HDL / Q000009:adverse effects / Q000097:blood*; D008078:Cholesterol, LDL / Q000009:adverse effects / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D012307:Risk Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL