title: Pilot study of nicardipine for acute ischemic stroke.
abstract: The author performed a pilot study of nicardipine (NC), a Ca(+)+ channel blocker, to study its dosing, toxicity, and possible efficacy for hemispheric cerebral infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability of proceeding with a multi-centered controlled trial. NC was administered IV (3 to 7 mg/hr) X 72 hours by titrating dose to mean arterial blood pressure (MABP not less than 10% of baseline), then orally X 30 days. Forty-three patients have been entered; mean age 63 (range 34-89), 25 male and 18 female. Only 3 had CT evidence of infarct on entry. Results have shown improvement in a 100-point (pt) graded exam (40 pts at entry, 68 pts at 3 months). Of 20 patients completing 3 months' evaluation, 17 improved and none worsened. Sixteen out of 20 were at home and 8 had minimal or no impairment. Mean Barthel's index was 72. Mean maximal serum NC level was 75 ng/mL. MABP decreased from 103 (entry) to 83 (72 hours). A larger controlled study is warranted to determine the efficacy of NC for acute cerebral infarct.
authors: Department of Neurology, University of Texas Medical School, Houston.
authors: D M
authors: DM
authors: Rosenbaum
authors: J C
authors: JC
authors: Grotta
authors: F M
authors: FM
authors: Yatsu
authors: C M
authors: CM
authors: Picone
authors: L C
authors: LC
authors: Pettigrew
authors: P
authors: P
authors: Bratina
authors: J
authors: J
authors: Zabramski
authors: R
authors: R
authors: Spetzler
authors: L
authors: L
authors: Lopez
authors: J
authors: J
authors: Marler
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D010865:Pilot Projects
chemical_list: D009529:Nicardipine