title: [Acute diltiazem poisoning: kinetic and hemodynamics study].
abstract: The authors report three cases of diltiazem overdose with hypotension and atrio-ventricular conduction disturbances. Hemodynamic study in 2 cases showed a hyperkinetic state with a decrease of systemic vascular resistances. Diltiazem kinetics studied in 2 cases showed a plasma half life of 5.4 and 8.3 hours, a prolonged absorption until the 28th hours in one case. Treatment included gastric lavage, oral activated charcoal (2 cases), plasma expanders and in 2 cases vasopressors with alpha effects. All three patients recovered.
authors: Service de Réanimation médicale et Centre Anti-Poisons, Pav. Pasteur, C.H.U., Strasbourg.
authors: A
authors: A
authors: Jaeger
authors: P
authors: P
authors: Sauder
authors: G
authors: G
authors: Bianchetti
authors: J
authors: J
authors: Kopferschmitt
authors: M
authors: M
authors: Dahlet
authors: L
authors: L
authors: Tritsch
authors: F
authors: F
authors: Flesch
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D004110:Diltiazem / Q000493:pharmacokinetics / Q000506:poisoning*; D005260:Female; D006207:Half-Life; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D011041:Poisoning / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004110:Diltiazem
vernacular_title: Intoxications aiguës par le diltiazem: étude cinétique et hémodynamique.