The influence of isosorbide dinitrate and molsidomine on migration of polymorphonuclear neutrophils in vivo.
There is evidence that accumulation of polymorphonuclear neutrophils exacerbates injury to the tissues during acute myocardial infarction. To evaluate the influence of the vasodilator drugs, isosorbide dinitrate and molsidomine on migration of polymorphonuclear neutrophils, the "skin chamber" method was used. The number of neutrophils harvested from the chamber after oral treatment with isosorbide dinitrate increased from 27.65 +/- 9.02 X 10(6)/cm2 to 69.08 +/- 11.41 X 10(6)/cm2. Migration of neutrophils after molsidomine did not change significantly. Both drugs exert a similar effect on vascular smooth muscle cells. The difference in the influence on migration of granulocytes might be the result of an additional effect of molsidomine on formation of thromboxane and/or effects on the lipoxygenic pathway of arachidonic acid.
Siminiak
T
T
Academy of Medicine, Department of Intensive Therapy, Poznań, Poland.
Wysocki
H
H
Szczepanik
A
A
D000208:Acute Disease; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology*; D008981:Molsidomine / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009203:Myocardial Infarction / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*
D008981:Molsidomine; D007548:Isosorbide Dinitrate