Distributions of perfusion and lung water.
We investigated the feasibility of using 123I-iodoantipyrine (123I-IAP) and 99mTc-labeled macroaggregated albumin (99mTc-MAA) to describe and compare the distributions of perfusion and water content in lung injuries. These radiopharmaceuticals were administered to 9 rabbits, 5 control and 4 with lung injuries. Isolated lungs were imaged by a scintillation gamma camera. The distribution of 123I-IAP outlined the entire lung mass whereas perfusion defect in the distribution of 99mTc-MAA was seen clearly in the case of severe lung injury.
Ekeh
S U
SU
Department of Radiological Sciences, Veterans Affairs Medical Center, Oklahoma City, OK 73104.
Chu
R Y
RY
Ficken
V J
VJ
Allen
E W
EW
Ryals
C J
CJ
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives; D015633:Extravascular Lung Water / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
D007457:Iodine Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D000983:Antipyrine; C008135:iodoantipyrine