title: Familial hyperuricemia and renal insufficiency.
abstract: A kindred is described in which hyperuricemia and renal insufficiency were observed in three generations. The hyperuricemia appeared to precede the renal diseases. Lowering the serum uric acid level to normal did not decrease the progression of renal insufficiency. This suggested that the hyperuricemia was a marker of a familial nephropathy and possibly not the cause.
authors: Department of Pediatrics, Children's Medical Center, Medical College of Virginia, Richmond.
authors: J W
authors: JW
authors: Foreman
authors: M
authors: M
authors: Yudkoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000235:genetics*; D008297:Male; D010375:Pedigree; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D000493:Allopurinol