title: [Exudative enteropathy and interstitial cystitis due to systemic lupus erythematosus].
abstract: A 33-year-old woman presented with chronic diarrhea, vomiting and anasarca due to systemic lupus erythematosus with protein-losing enteropathy, interstitial cystitis and glomerulonephritis. Methylprednisolone could not prevent aggravation of diarrhea, obstructive uropathy, and nephrotic syndrome, and prolonged intestinal ileus developed. Because of this steroid-resistance, bolus injections of cyclophosphamide (1 g i.v. monthly) were decided. Protein-losing enteropathy and ileus both disappeared rapidly following the first injection. Protein-losing enteropathy, intestinal ileus and interstitial cystitis are exceptional manifestations of systemic lupus erythematosus; steroid-resistance of the digestive manifestations has only been reported in one case and our observation is the first reporting the efficacy of cyclophosphamide.
authors: Cliique d'Hépato-Gastroentérologie, Hôpital Saint-Antoine, Paris.
authors: P
authors: P
authors: Marteau
authors: J D
authors: JD
authors: Grange
authors: C
authors: C
authors: Michel
authors: J F
authors: JF
authors: Mosnier
authors: S
authors: S
authors: Islam
authors: A
authors: A
authors: Najman
authors: F
authors: F
authors: Mignon
authors: F
authors: F
authors: Bodin
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use*; D003556:Cystitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000209:etiology*; D014567:Urography
chemical_list: D003520:Cyclophosphamide
vernacular_title: Entéropathie exsudative et cystite interstitielle au cours d'un lupus érythémateux disséminé.