title: [A comprehensive evaluation of the biological properties of the causative agents of typhoid fever isolated from patients and carriers].
abstract: The biological properties of 106 S. typhi cultures were studied; of these, 59 cultures were isolated from 45 chronic carriers and 47 cultures, from 23 typhoid fever patients. According to the degree of their virulence (CPD50 in the continuous cell-line culture Hep-2), the strains isolated from the patients were more virulent than those isolated from the chronic carriers. The mean value of lg CPD50 was 5.76 +/- 0.04 for the patients and 6.86 +/- 0.03 for the chronic carriers. The strains isolated from the patients showed greater variability in the degree of their virulence. The study of the plasmid spectrum showed that 9.4 +/- 5.6% of the strains contained plasmids. From the patients plasmid-containing strains were isolated more frequently than from the carriers (14.9 +/- 2.5% and 5.1 +/- 2.9%). Multiresistance to antibiotics in combination with the presence of plasmids was detected in 6 strains isolated from the typhoid patients with morbidity having the character of outbreaks.
authors: S L
authors: SL
authors: Kolpakov
authors: T F
authors: TF
authors: Semenova
authors: E I
authors: EI
authors: Vostrova
authors: N I
authors: NI
authors: Kashanova
authors: G I
authors: GI
authors: Golovenko
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001434:Bacteriophage Typing; D001437:Bacteriuria / Q000382:microbiology; D002353:Carrier State / Q000382:microbiology*; D002478:Cells, Cultured / Q000382:microbiology; D002908:Chronic Disease; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D012485:Salmonella typhi / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity; D018805:Sepsis / Q000382:microbiology; D014435:Typhoid Fever / Q000382:microbiology*; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Kompleksnaia otsenka biologicheskikh svoĭstv vozbuditeleĭ briushnogo tifa, vydelennykh ot bol'nykh i nositeleĭ.