Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice.
Senescence accelerated mice (SAM-P) were used for the study of the possible aging of hemopoiesis. The number of peripheral leukocytes decreased significantly with age, whereas hematocrit showed only a slight decrease. Although the number of total nucleated cells in the bone marrow increased, the number of hemopoietic stem cells (CFU-S) as well as that of granulocyte-macrophage colony forming cells (GM-CFC) showed a decrease in old mice. A significant decrease in the number of GM-CFC was observed in the spleen of old SAM-P mice, whereas no decrease was found in the number of CFU-S. Such a profound reduction of the recruitment of GM-CFC from CFU-S in the spleen together with a reduction of bone marrow hemopoiesis may be responsible for the decrease in the number of peripheral leukocytes in the old mice. SAM-P mice could provide a good model for the study of the aging of hemopoietic system.
Izumi-Hisha
H
H
Department of Hygiene, Aichi Medical University, Japan.
Ito
Y
Y
Sugimoto
K
K
Oshima
H
H
Mori
K J
KJ
D000375:Aging / Q000473:pathology*; D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells; D002452:Cell Count; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D013154:Spleen / Q000166:cytology