title: Does suxamethonium influence the subsequent dose requirements of alcuronium and its reversibility in children?
abstract: Suxamethonium is often used for intubation prior to the use of a nondepolarizing muscle relaxant. This study was performed to determine whether suxamethonium altered the dose of alcuronium required to produce neuromuscular block. The findings were that suxamethonium 1.0 mg/kg did not alter the depth, duration or reversibility of block if given before alcuronium 0.3 mg/kg. Reversal with neostigmine was more rapid following 50 micrograms/kg than after 25 micrograms/kg. If recovery from neuromuscular block was greater than 25 per cent, the lower dose produced satisfactory reversal, whether or not suxamethonium had been given previously.
authors: Royal Children's Hospital, Parkville, Victoria, Australia.
authors: T C
authors: TC
authors: Brown
authors: O A
authors: OA
authors: Meretoja
authors: D
authors: D
authors: Clare
authors: B
authors: B
authors: Bell
mesh_terms: D000293:Adolescent; D000443:Alcuronium / Q000008:administration & dosage* / Q000494:pharmacology; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D009388:Neostigmine; D013390:Succinylcholine; D000443:Alcuronium