title: [Immunogenetic approaches to the study of leukemia in humans].
abstract: One hundred and ten families having one child suffering from acute leukemia were included in HLA studies. These families were found to have unequal distribution of the parent HLA-haplotypes among the sibs. Three groups of families were conditionally distinguished. The first group showed the predominance of one parental, the second group of one maternal, and the third group of one maternal and one paternal HLA haplotypes. This suggests that impairment of the evolutionally derived principle of equal participation of both gamete types of each parent in the zygote formation is deleterious for the progeny.
authors: E A
authors: EA
authors: Zotikov
authors: N A
authors: NA
authors: Krasnikova
authors: R M
authors: RM
authors: Kut'ina
authors: A I
authors: AI
authors: Udovichenko
authors: L S
authors: LS
authors: Liubimova
mesh_terms: D000208:Acute Disease; D000328:Adult; D002648:Child; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006801:Humans; D007125:Immunogenetics; D007938:Leukemia / Q000235:genetics*; D015053:Zygote
chemical_list: D006680:HLA Antigens
vernacular_title: Immunogeneticheskie podkhody k izucheniiu leĭkozov cheloveka.