Renal hypertension in rats with hereditary polycystic kidney disease.
Hereditary polycystic kidney disease (PKD) was observed in a Han:SPRD rat mutant. Cysts were of tubular origin and occurrence was more pronounced in males than in females. In male rats polycystic kidney disease was associated with a marked elevation of systolic blood pressure. Therefore this rat mutant can be considered as a laboratory animal model for renal hypertension associated with adult polycystic kidney disease in man.
Kaspareit-Rittinghausen
J
J
Central Institute for Laboratory Animal Breeding, Hannover, F.R.G.
Deerberg
F
F
Rapp
K G
KG
Wcislo
A
A
D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D005260:Female; D006977:Hypertension, Renal / Q000209:etiology*; D007668:Kidney / Q000473:pathology; D008297:Male; D007690:Polycystic Kidney Diseases / Q000150:complications* / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains