[The predictability of inspiratory and endexpiratory concentrations of isoflurane and enflurane using pharmacokinetic models and interindividual variability].
The predictability of the inspiratory and endexpiratory concentrations of the volatile anaesthetics isoflurane and enflurane by pharmacokinetic models was investigated. 67 patients of ASA-classes 1-2 that underwent minor surgical procedures were studied. The pharmacokinetic model consisted of two parts, a model of the anaesthesia machine and a model of the patient. The mean values of the predicted/measured concentrations of isoflurane had an amount of 1.01 +/- 0.13 (inspiratory) and 0.97 +/- 0.13 (endexpiratory), the mean values of enflurane showed a value of 1.00 +/- 0.11 (inspiratory) and 0.97 +/- 0.13 (endexpiratory). The interindividual variances amounted to between 10% and 40% of the variance of all patients. This corresponded to a standard deviation of about 6% (inspiratory) while the endexpiratory concentrations showed a standard deviation about 8% for the average values of every patient.
Schwilden
H
H
Institut für Anästhesiologie, Rheinische Friedrich-Wilhelms-Universität Bonn.
Tonner
P H
PH
Röpcke
H
H
D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D004737:Enflurane / Q000493:pharmacokinetics*; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D007530:Isoflurane / Q000493:pharmacokinetics*; D008875:Middle Aged; D008954:Models, Biological; D010599:Pharmacokinetics
D004737:Enflurane; D007530:Isoflurane
Voraussagbarkeit in- und endexspiratorischer Isofluran- und Enflurankonzentrationen durch pharmakokinetische Modelle und interindividuelle Variabilität.