Plasma levels of chloroquine in healthy Nigerian children: clinical and toxicological implications.
1. Sixteen healthy children attending the Well Baby Clinic of the University of Nigeria Teaching Hospital, Enugu were studied. 2. Upon obtaining a medication history that was negative for chloroquine over a three week period, a single random sample of venous blood was taken from each child for chloroquine analysis. 3. Analysis of plasma for chloroquine was done using an h.p.l.c. method. 4. Plasma levels of chloroquine in the children ranged from 77.8-224.7 ng/ml with a mean of 156.5 +/- 67.8 s.d. 5. In view of the danger of acute toxicity as well as the long-term effects, further studies are needed to determine the harmful effects such perennial presence of chloroquine, albeit in low levels, may have on our children.
Ogbuokiri
J E
JE
Department of Pharmacology & Therapeutics, University of Nigeria Teaching Hospital, Enugu.
D002662:Child Health Services; D002675:Child, Preschool; D002738:Chloroquine / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D006784:Hospitals, Teaching; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008297:Male; D009549:Nigeria; D010044:Outpatient Clinics, Hospital; D012651:Self Medication / Q000009:adverse effects
D002738:Chloroquine