Effect of nutritional status on mutagenicity of urine excreted by rats treated with standard/experimental carcinogens.
Urine samples, collected from Sprague Dawley rats treated with extracts of tobacco/masheri, benzo (a) pyrene, N'-nitrosonornicotine, N'-nitrosodiethylamine and maintained on semi-synthetic diets sufficient or deficient in Vitamin A, B and protein were tested for mutagenicity using Salmonella/microsome assay. The mutagenic activity of urine or various treated groups was in the order deficient diet greater than standard laboratory diet greater than nutritionally sufficient diet. Present results confirmed the earlier observations that nutritionally deficient animals are likely to have more exposure to mutagenic metabolites that are generated by increased phase I enzymes and decreased detoxification system.
Ammigan
N
N
Carcinogenesis Division, Cancer Research Institute, Bombay, India.
Nagabhushan
M
M
Nair
U J
UJ
Amonkar
A J
AJ
Bhide
S V
SV
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics*; D008658:Inactivation, Metabolic; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000652:urine*; D009748:Nutrition Disorders / Q000378:metabolism*; D011488:Protein Deficiency / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D014802:Vitamin A Deficiency / Q000378:metabolism; D014804:Vitamin B Deficiency / Q000378:metabolism
D002273:Carcinogens; D009153:Mutagens