Effects of cerulenin, an inhibitor of fatty acid synthesis on reconstitution of the dental basement membrane.
When trypsin-dissociated enamel organs and dental papillae were recombined in the presence of cerulenin--an antibiotic which is a potent inhibitor of fatty acid synthesis--the newly synthesized basement membrane seemed defective in a dose-dependent manner. The three-dimensional relationship between the basement membrane components and the plasma membrane appears to be regulated in part by lipids.
Goldberg
M
M
Laboratoire d'Histologie, Faculté de Chirurgie Dentaire, Université René Descartes, Montrouge, France.
Lecolle
S
S
Lesot
H
H
Ruch
J V
JV
D000818:Animals; D001345:Autoradiography; D001485:Basement Membrane / Q000187:drug effects / Q000648:ultrastructure; D002569:Cerulenin / Q000494:pharmacology*; D003771:Dental Papilla / Q000187:drug effects* / Q000648:ultrastructure; D004658:Enamel Organ / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D014316:Tritium; D014357:Trypsin
D009829:Oleic Acids; D014316:Tritium; D002569:Cerulenin; D019301:Oleic Acid; D014357:Trypsin