title: Expression of the calcitonin gene during migration of the Pacific salmon, Oncorhynchus gorbuscha.
abstract: Plasma calcitonin levels increase during reproduction in female salmon. Whether these changes in circulating levels of the hormone are due to increased secretion and or increased biosynthesis is not established. We measured total and poly A+ RNAs and calcitonin content of ultimobranchial bodies of male and female pink salmon during the different stages of the reproductive cycle. Calcitonin mRNAs were analysed by hybridization of northern and dot blots with a specific probe for salmon calcitonin. Dot blot autoradiography indicated that female animals had higher levels of CT mRNA than males and these values were correlated with plasma calcitonin levels. In conclusion, sexual hormones still to be identified, are probably implicated in the expression of the calcitonin gene in females during the reproductive cycle.
authors: U. 113 INSERM, CHU Saint-Antoine, Paris, France.
authors: L
authors: L
authors: Maubras
authors: M
authors: M
authors: Cressent
authors: S
authors: S
authors: Minvielle
authors: J
authors: J
authors: Taboulet
authors: A
authors: A
authors: Jullienne
authors: G
authors: G
authors: Milhaud
authors: M S
authors: MS
authors: Moukhtar
mesh_terms: D000818:Animals; D001345:Autoradiography; D002116:Calcitonin / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D014644:Genetic Variation; D008297:Male; D011061:Poly A / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D012098:Reproduction / Q000235:genetics*; D012474:Salmon / Q000235:genetics*; D014460:Ultimobranchial Body / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D011061:Poly A; D002116:Calcitonin