title: Safety evaluation of a potent tetanus vaccine (250 Lf) in guinea pigs (Cavia procellus).
abstract: A subacute toxicity study of a potent tetanus toxoid (250 Lf) was carried out in guinea pigs. The toxoid was injected subcutaneously at the nape of the neck at dose levels of 1.0, 1.5, and 2.0 ml in Groups II, III, and IV, respectively. In the controls (Group I) 2.0 ml of aluminum phosphate suspension was given in each injection. Periodic evaluations of body weight, food/water intake, general observable behavior, hematology, and blood chemistry in toxoid-injected guinea pigs were similar to those in control guinea pigs. Thus, the toxoid did not cause any side effects up to four times the dose proposed for humans.
authors: Division of Toxicology, Central Drug Research Institute, Lucknow, India.
authors: N
authors: N
authors: Sethi
authors: R K
authors: RK
authors: Srivastava
authors: R K
authors: RK
authors: Singh
authors: S
authors: S
authors: Srivastava
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006403:Hematologic Tests; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013745:Tetanus Toxoid / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D013745:Tetanus Toxoid