[Physiological and pharmacological actions of a neuroactive dipeptide, kyotorphin, and its precursor, L-arginine, and clinical application].
This review describes: 1. Recent findings about the physiological and pharmacological actions of kyotorphin that was isolated from the brain. 2. Biosynthesis, distribution, release, uptake, enzymatic destruction of this peptide in the body. 3. L-Arginine was found to be a precursor of kyotorphin. 4. Clinical application of the precursor to the treatment of chronic pain.
Takagi
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Japan.
D000700:Analgesics; D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism; D002908:Chronic Disease; D004723:Endorphins / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D010146:Pain / Q000188:drug therapy*
D000700:Analgesics; D004723:Endorphins; C019448:kyotorphin; D001120:Arginine