Platelet aggregation of migraineurs during and between attacks.
Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks. The EC50* values for ADP and platelet-activating factor were significantly higher, whilst that for collagen was significantly lower in classical migraine patients during headache-free intervals compared to healthy volunteers. The EC50 values obtained for common migraine sufferers during symptom-free periods were similar to those of controls. During attacks, the EC50 value for ADP, but not for collagen and platelet-activating factor, was significantly higher than that of the controls. In healthy subjects a positive correlation was found between ADP and collagen-induced aggregation. In contrast, there was a U-shaped correlation matrix in classical migraine patients. The present observations show that platelet aggregation is altered in migraine patients and this raises the possibility that platelet-activating factor may be involved in the pathogenesis of migraine.
Kovács
K
K
Institute of Neurology, Semmelweis Medical University, Budapest, Hungary.
Hermán
F
F
Filep
J
J
Jelencsik
I
I
Magyar
K
K
Csanda
E
E
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000209:etiology; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors
D001779:Blood Coagulation Factors; D010972:Platelet Activating Factor; D000244:Adenosine Diphosphate; D003094:Collagen