[Study on the fibrin fibrinogen degradation products levels and it's significance in the phlegm of the patients with chronic cor pulmonale through monoclonal antibodies].
For the first time, we determined the levels of FDP in phlegm of the patients with chronic cor pulmonale and normal subjects by the TRCHII with the McAbs. Antihuman FDP McAb was applied the clinic, hence, the specificity and sensitivity of TRCHII method for detecting FDP was increased, facilitating clinical application. The results showed that the FDP level of the patients was significantly higher than that of normal subjects (P less than 0.05), but there was no significant difference between the levels of the patients of acute stage and those of remission stage. (P greater than 0.05). The main reason for the increased FDP levels in the phlegm of the patients with chronic cor pulmonale is probably due to the pathological change of the disease-recurrent infections, anoxemia, hypercoagulability and so on. The detection of FDP is helpful for the diagnosis, treatment, evaluation of prognosis of the disease. It provides an index for the observation of tissue damage of lung, especially the damage of capillary endothelia of the lung.
He
G Z
GZ
Institute of Respiratory Disease of Ji Lin Province, Changchun.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000378:metabolism*; D013183:Sputum / Q000737:chemistry*
D000911:Antibodies, Monoclonal; D005338:Fibrin Fibrinogen Degradation Products