[Pharmacological availability of erythromycin granules for children's use].
Pharmaceutical availability of erythromycin granules with polymeric coating of different composition+ was studied. With an account of the ++anatomo-physiological features of a child organism and the properties of the antibiotic, acetylphthalyl cellulose in combination with hydroxypropyl methylcellulose or methyl cellulose was used as a film forming agent. The coated granules were estimated by such parameters as the time of disintegration and the rate of dissolution in various media. The results of the study showed that coating of the erythromycin granules with the film composed of acetylphthalyl cellulose and hydroxypropyl methylcellulose in the ratio of 8 to 2 provided the required protection of the antibiotic in acid media and high pharmaceutical availability of the drug.
Korenev
S V
SV
Garsheva
G B
GB
Nesterova
L Ia
LIa
Grakovskaia
L K
LK
Tentsova
A I
AI
D004353:Drug Evaluation, Preclinical; D004917:Erythromycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology; D012995:Solubility; D013608:Tablets, Enteric-Coated
D013608:Tablets, Enteric-Coated; D004917:Erythromycin
Farmatsevticheskaia dostupnost' detskoĭ lekarstvennoĭ formy éritromitsina v vide granul.