title: [The individual characteristics of the excretion of benzo(a)pyrene metabolites in rats].
abstract: Assessment of individual peculiarities of carcinogen metabolism in the body opens up new vistas in predicting individual sensitivity to these agents. The authors developed a spectrofluorometric [correction of spectrofluorescence] technique to assay concentrations of carcinogenic benzo(a)-pyrene (BP) metabolite (7,8-BP) and a product of its detoxication (3-BP) in excreta of male rats who had been given a single dose of 200 mg/kg of benzo(a)pyrene intraperitoneally. Ten-thirty times daily variations in individual levels of both metabolites were accompanied by less variation in their total amount. Parameters of BP metabolism perhaps can be used for predicting individual risk of BP-induced tumor development.
authors: I V
authors: IV
authors: Savochkina
authors: P P
authors: PP
authors: Dikun
authors: M A
authors: MA
authors: Zabezhinskiĭ
authors: V A
authors: VA
authors: Iamshanov
authors: A Ia
authors: AIa
authors: Likhachev
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000032:analysis / Q000493:pharmacokinetics*; D001580:Benzopyrenes / Q000032:analysis; D001711:Biotransformation; D004101:Dihydroxydihydrobenzopyrenes / Q000032:analysis; D005243:Feces / Q000737:chemistry; D008297:Male; D051381:Rats; D013050:Spectrometry, Fluorescence / Q000379:methods; D013997:Time Factors
chemical_list: D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; C017228:benzo(a)pyrene 7,8-dihydrodiol; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene
vernacular_title: Individual'nye osobennosti ékskretsii metabolitov benz(a)pirena u krys.