title: A case of methimazole-induced acute hepatic failure in a patient with chronic hepatitis B carrier.
abstract: We report a case of methimazole-induced acute hepatic failure, which occurred 17 weeks after initiation of the drug in a 43-year-old man with hyperthyroidism and hepatitis B surface antigenemia. Postmortem needle autopsy of the liver revealed an established micronodular cirrhosis secondary to hepatitis B with moderate septal/portal inflammation, marked cholestasis and scattered acidophilic bodies. The serum hepatitis B surface antigen (HBsAg) was positive, but reactivation of hepatitis B was unlikely in view of the absence of a serum hepatitis B e antigen (HBeAg) and hepatitis B virus deoxyribonucleic acid (HBV-DNA) and negative stain for HBsAg and hepatitis B core antigen (HBcAg) in the liver tissue.
authors: Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea.
authors: H
authors: H
authors: Kang
authors: J D
authors: JD
authors: Choi
authors: I G
authors: IG
authors: Jung
authors: D W
authors: DW
authors: Kim
authors: T B
authors: TB
authors: Kim
authors: H K
authors: HK
authors: Shin
authors: B T
authors: BT
authors: Kim
authors: C K
authors: CK
authors: Park
authors: J Y
authors: JY
authors: Yoo
mesh_terms: D000208:Acute Disease; D000328:Adult; D002353:Carrier State; D056486:Chemical and Drug Induced Liver Injury; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008297:Male; D008713:Methimazole / Q000009:adverse effects*
chemical_list: D008713:Methimazole