title: Endogenous angiotensin II regulates hepatic angiotensinogen production.
abstract: We have investigated the effects of endogenous angiotensin II (ANG II) on hepatic angiotensinogen mRNA levels in rats. Changes in endogenous ANG II were induced by various sodium intakes (standard-, low-, and high-sodium) or by enalapril treatment. In a low sodium state for 2 weeks, angiotensinogen mRNA levels and plasma ANG II concentration increased 1.3-fold and 1.6-fold compared to those in standard sodium state, respectively. In a high sodium state, angiotensinogen mRNA levels and plasma ANG II concentration decreased by 42% and 56% compared to the standard sodierm state, respectively. Four hours after treatment with enalapril (3 mg/kg), angiotensinogen mRNA level and plasma ANG II concentration decreased by 25% and 12% compared to the standard sodium state, respectively. There was a close correlation between angiotensinogen mRNA level and plasma ANG II concentration (r = 0.79, P less than 0.01). These results suggest that endogenous ANG II may play an important role in the regulation of hepatic angiotensinogen synthesis.
authors: Department of Pharmacology, Kagawa Medical School, Japan.
authors: H
authors: H
authors: Iwao
authors: A
authors: A
authors: Nakamura
authors: K
authors: K
authors: Fukui
authors: S
authors: S
authors: Kimura
authors: T
authors: T
authors: Tamaki
authors: Y
authors: Y
authors: Abe
mesh_terms: D000804:Angiotensin II / Q000097:blood*; D000808:Angiotensinogen / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D004656:Enalapril / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D012333:RNA, Messenger; D000808:Angiotensinogen; D000804:Angiotensin II; D004656:Enalapril; D012964:Sodium