Establishment of functional T cells in SCID mice does not lead to termination of pregnancy.
Syngeneic (CB20) thymus and spleen T cells transferred to SCID mice, and shown to be present by flow cytometric analysis and functional by their ability to reject third-party skin grafts, do not lead to a detectable failure of syngeneic or allogeneic pregnancy. Unless the small number of B cells contaminating the T-cell innocula are capable of mounting a blocking antibody response, it is concluded that these results show that a humoral ('blocking antibody') response is not essential for successful pregnancy.
Hetherington
C M
CM
National Institute for Medical Research, London U.K.
Dresser
D W
DW
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001667:Binding, Competitive / Q000276:immunology; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013950:Thymus Gland / Q000276:immunology
D000906:Antibodies