[Blood pressure monitoring in aged hypertensive patients treated with sustained-release nicardipine or nifedipine].
In a double-blind parallel study, 20 elderly hypertensive subjects (mean age 85 years) were treated either by nicardipine or by nifedipine in slow-release form for 7 days. Blood pressure was measured by ambulatory, non-invasive daytime monitoring. Efficacy of both drugs was similar on the seventh day of treatment. However, the hypotensive effect induced by nifedipine was maximal on the first day of treatment, in contrast to the progressive effect induced by nicardipine. In 2 cases, marked hypotension was observed after the first tablet of nifedipine.
Loew
F
F
Institutions universitaires de gériatrie, Hôpital cantonal universitaire de Genève.
Gauthey
L
L
Donath
R
R
Petitot
C
C
Herrmann
F
F
Jacot Des Combes
B
B
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009529:Nicardipine / Q000627:therapeutic use*; D009543:Nifedipine / Q000627:therapeutic use*
D009529:Nicardipine; D009543:Nifedipine
Monitoring tensionnel chez des hypertendus âgés traités par nicardipine ou nifédipine à libération prolongée.