Cloning and sequencing of human LH/hCG receptor cDNA.
We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).
Minegishi
T
T
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
Nakamura
K
K
Takakura
Y
Y
Miyamoto
K
K
Hasegawa
Y
Y
Ibuki
Y
Y
Igarashi
M
M
Minegish T [corrected to Minegishi
T ]
T]
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D011974:Receptors, LH / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
D011974:Receptors, LH; D004247:DNA