[The role of microsomal oxidation processes in the development of haloperidol tolerance during melatonin administration and epiphysectomy in rats].
A pineal hormone melatonin (1 mg/kg, 24 days) facilitated the formation of tolerance to haloperidol and eliminated the changes produced by it in the processes of microsomal oxidation in rats. Pinealectomy yielded the opposite result. After pinealectomy the normalizing effect of the hormone on the condition of the liver monoxygenase system and the effects of haloperidol weakened.
Arushanian
E B
EB
Zarubin
V V
VV
Popov
A V
AV
Luneva
T M
TM
D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010105:Oxygenases / Q000187:drug effects / Q000378:metabolism; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D051381:Rats
D010105:Oxygenases; D006220:Haloperidol; D008550:Melatonin
Uchastie protsessov mikrosomal'nogo okisleniia v formirovanii tolerantnosti v galoperidolu pri vvedenii melatonina i épifizéktomii u krys.