Immunologic protection against VX intoxication in experimental animals.
Rabbits immunized with an artificial VX-antigen could survive 1 x LD95 of VX challenge on the 7th day and the 31st day after the last immunization. One hundred microliters of rabbit anti-VX antiserum given intravenously immediately before 1 x LD95 of VX or 200 microliters of antiserum intraperitoneally 1-10 days before 1 x LD95 VX protected all the tested mice from death. The antiserum could prevent the in vitro inhibition of Torpedo AChE activity by VX and reduced its effect on brain AChE activity in vivo. No protective effect of the antiserum was observed on the Torpedo AChE activity inhibited by sarin and soman.
Rong
K T
KT
Institute of Pharmacology and Toxicology, Beijing, China.
Zhang
L J
LJ
D000110:Acetylcholinesterase / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000276:immunology / Q000506:poisoning*; D005260:Female; D007110:Immunity, Active / Q000276:immunology*; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000276:immunology / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D011817:Rabbits; D013997:Time Factors; D014612:Vaccines / Q000276:immunology*
D000110:Acetylcholinesterase; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D014612:Vaccines; C009680:VX-agent