[Alterations of c-myc and c-Ha-ras-1 oncogenes in human ovarian cancer].
Fourteen cases of the ovarian carcinoma (OC) were studied for alterations of c-myc and c-Ha-ras-1 oncogens. Amplification of c-myc was found in four aggressive and widespread OC. An increased frequency of one of the four common alleles of c-Ha-ras-1-allele A4-was determined in OC patients. Rearrangements of c-Ha-ras-1-allelic deletions and change in the allele fragment length-were found in all OC with A4 allele. In contrast, no alterations were detected in tumours without allele A4. Thus allele A4 of c-Ha-ras-1 may be viewed as a genetic marker of predisposition to OC in combination with other clinical parameters. Alterations of c-myc and c-Ha-ras-1 oncogens were observed in 8 out of 14 OC samples suggesting that the development of this type of human neoplasm is due to rearrangements of these genes.
Serova
O M
OM
Nikiforova
I F
IF
Iurkova
L E
LE
Vinokurov
V L
VL
Kniazev
P G
PG
D000483:Alleles; D002874:Chromosome Mapping; D005260:Female; D016259:Genes, myc; D011905:Genes, ras; D005819:Genetic Markers; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis
D005819:Genetic Markers; D016271:Proto-Oncogene Proteins c-myc; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Povrezhdenie lokusov onkogenov c-myc i c-Ha-ras-1 v rake iaichnika cheloveka.