title: Epimerization of erythromycin derivatives.
abstract: Dirithromycin (3) isomerizes upon dissolution in different solvents. From X-ray analysis of V-T 108, an analogue of dirithromycin, and comparative 1H and 13C NMR, and MS data, the isomer of dirithromycin was confirmed to be the C-16-(S)-epimer. The ratio of the two epimers at equilibrium conditions was approximately 8:2 (R/S) in methanol at room temperature.
authors: Organisch-chemisches Institut, Technische Universität München, Garching, FRG.
authors: J
authors: J
authors: Firl
authors: A
authors: A
authors: Prox
authors: P
authors: P
authors: Luger
authors: R
authors: R
authors: Maier
authors: E
authors: E
authors: Woitun
authors: K
authors: K
authors: Daneck
mesh_terms: D000900:Anti-Bacterial Agents; D002855:Chromatography, Thin Layer; D003460:Crystallization; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C053853:dirithromycin; D004917:Erythromycin