[Effects of BY-1949 on three kinds of experimental amnesia in rodents].
The possible anti-amnesic effects of a dibenzoxazepine derivative, BY-1949 (3-methoxy-11-methyldibenz[b,f] [1, 4] oxazepine-8-carboxylate), were examined using the three learning paradigms. In the one-trial passive avoidance task in mice, BY-1949 (1-30 mg/kg, po) and aniracetam (3-30 mg/kg, po) reversed the shortening of the response latency in the retention test produced by exposure to 100% CO2 immediately after the acquisition trial. In the two-way active avoidance task in rats, BY-1949 (10, 30 mg/kg, po) reversed the decreased avoidance rate produced by the hypoxia treatment (5% O2:95% N2). In the radial-arm maze task in rats, BY-1949 (10 mg/kg, po) and aniracetam (10, 30 mg/kg, po) improved the impaired correct choices induced by scopolamine (0.25 mg/kg, ip). These results suggest that BY-1949, as well as aniracetam, exerts some improvement effects on experimental amnesia.
Tanabe
S
S
Exploratory Research Laboratories, Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan.
Ikeda
Y
Y
Sugawa
M
M
Iwasaki
T
T
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003989:Dibenzoxazepines / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D011760:Pyrrolidinones / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D003989:Dibenzoxazepines; D011760:Pyrrolidinones; C036466:aniracetam; C058844:3-methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate