The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro.
Ten renal carcinomas were established in culture and their sensitivity to mitozantrone +/- verapamil, as measured by (75Se) selenomethionine incorporation, was studied. The 5 tumours with spread beyond the kidney were those in which sensitivity to mitozantrone was enhanced by verapamil. With 4 of the 10 tumours and 1 further carcinoma, similar experiments were performed using doxorubicin. This drug was more active, its anti-tumour action being related to concentration. Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added.
Lai
T
T
Department of Surgery, Royal Infirmary, Bristol.
Morgan
A P
AP
Smith
P J
PJ
Symes
M O
MO
D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008942:Mitoxantrone / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012645:Selenomethionine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014700:Verapamil / Q000494:pharmacology*
D009363:Neoplasm Proteins; D004317:Doxorubicin; D012645:Selenomethionine; D008942:Mitoxantrone; D014700:Verapamil