title: Impairment of ATP-linked reactions in mitochondria isolated from skeletal muscle of halothane-sensitive pigs.
abstract: Oxygen consumption was depressed in mitochondria isolated from halothane sensitive pig (HP) muscle. The calculation of the respiratory control ratio (RCR) indicated that mitochondria were more affected at the site-I level of the respiratory chain. Calcium accumulation in these mitochondria was not altered when driven by the oxidation of succinate. This process was abolished when linked to ATP as a source of energy. ATP transport was completely inhibited in (HP) mitochondria.
authors: Institut National de Recherche Agronomique (INRA), Ceyrat, France.
authors: S
authors: S
authors: Ayoub
authors: G
authors: G
authors: Monin
authors: E
authors: E
authors: Rock
authors: A
authors: A
authors: Younes
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006221:Halothane / Q000009:adverse effects*; D066298:In Vitro Techniques; D008931:Mitochondria, Muscle / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D013552:Swine
chemical_list: D000255:Adenosine Triphosphate; D006221:Halothane