[Protective effect of selenium in acute T-2 mycotoxicosis].
Male Wistar rats were fed diets supplemented with selenium (0.5 and 2.5 mg/kg) for 6 weeks. When T-2 toxin was administered at 3.8 mg/kg body weight; sings of intoxication were less distinct in rats fed selenium-supplemented diets. Mortality caused by T-2 toxin was two times lower if selenium content amounted to 2.5 mg/kg. The level of cytochrome P-450 and the rate of deethylation of 7-ethoxycoumarin were considerably decreased in the liver of rats that received T-2 toxin and fed a diet with high selenium content. At the same time the activity of epoxide hydrolase and UDP-glucuronosyltransferase was significantly higher (1.6 and 1.7 times more) as compared with unsupplemented group. The results obtained allow to assume that there is a relationship between the decrease of T-2 toxin toxicity and the change in its metabolism in rats fed selenium-supplemented diets.
Kravchenko
L V
LV
Kuz'mina
E E
EE
Avren'eva
L I
LI
Tutel'ian
V A
VA
D000818:Animals; D004032:Diet; D005517:Foodborne Diseases / Q000378:metabolism / Q000517:prevention & control*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000627:therapeutic use*; D013605:T-2 Toxin / Q000378:metabolism / Q000506:poisoning*
D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium; D013605:T-2 Toxin
Zashchitnoe deĭstvie selena pri ostrom T-2-mikotoksikoze.