title: True hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, 46,XX/46,XY karyotype, and a successful pregnancy.
abstract: The first case (to the authors' knowledge) is reported of a true hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, a 46, XX/46,XY karyotype, and a successful pregnancy. The true hermaphroditism was diagnosed during infancy. The patient was subsequently found to have a gonadoblastoma and a microscopic dysgerminoma in the gonad diagnosed as an ovotestis and excised during infancy. The successful pregnancy occurred when the patient was 29 years old. A year later a large gonadal tumor affecting the remaining gonad was excised. The gonad was found to be an ovotestis, and the tumor was a dysgerminoma arising from a gonadoblastoma. This case further emphasizes the malignant potential of the Y chromosome in patients with abnormal gonads.
authors: Department of Pathology, University of Chicago, Illinois.
authors: A
authors: A
authors: Talerman
authors: M S
authors: MS
authors: Verp
authors: E
authors: E
authors: Senekjian
authors: T
authors: T
authors: Gilewski
authors: N
authors: N
authors: Vogelzang
mesh_terms: D012734:Disorders of Sex Development / Q000150:complications* / Q000235:genetics / Q000473:pathology; D004407:Dysgerminoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006066:Gonads / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011247:Pregnancy