Pyretic action of low doses of gamma-hydroxybutyrate in rats.
gamma-Hydroxybutyrate (GHB) has been found to have a biphasic effect on body temperature with increased body temperature after low doses (5-10 mg/kg) and decreased body temperature after high doses (300-500 mg/kg). Brain levels of GHB between 30 and 60 min post-injection of GHB were not altered by the low doses (5-10 mg/kg), although a dose of 200 mg/kg produced a large increase in the brain concentration.
Kaufman
E E
EE
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
Porrino
L J
LJ
Nelson
T
T
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
D012978:Sodium Oxybate