title: Aging-related alterations in human upper esophageal sphincter function.
abstract: Recent improvements in manometric catheters have made measurement of pharyngeal (P) and upper esophageal sphincter (UES) swallowing mechanics more reliable. Few studies have attempted to evaluate the effect of normal aging on P and UES mechanics. Pharyngeal and upper esophageal sphincter dynamics were studied in 10 healthy elderly adults (age greater than 60; range 62-79 yr) and 10 younger adults (age less than 60; range 24-59 yr). A solid-state intraluminal transducer system was used with a proximal unidirectional Konigsberg microtransducer and a circumferential (sphincter) transducer located 5 cm distally. Mean resting UES pressure was significantly (p less than 0.05) lower in the elderly than in the younger subjects (52 +/- 5 vs 72 +/- 6 (SE)) mm Hg. A significant inverse relation (R = -0.54; p less than 0.02) was found between age and resting UES pressure. Time from peak of pharyngeal contraction to UES nadir was significantly (p less than 0.05) shortened in the healthy elderly vs younger controls (10 +/- 30 vs 90 +/- 20 ms) during dry swallows. Our studies indicate that aging is associated with lower resting UES pressure and delayed UES relaxation, relative to the pharyngeal peak.
authors: Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors: S R
authors: SR
authors: Fulp
authors: C B
authors: CB
authors: Dalton
authors: J A
authors: JA
authors: Castell
authors: D O
authors: DO
authors: Castell
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003679:Deglutition / Q000502:physiology*; D004947:Esophagus / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010614:Pharynx / Q000502:physiology*; D011312:Pressure; D012016:Reference Values