title: [Infection of repair-deficient human cells by the vaccinia virus decreases the formation of gamma-induced DNA breaks].
abstract: The alkaline elution method was used to study DNA breaks induced by the different mutagens in human cells. Normal fibroblasts and fibroblasts from patients with homocystinuria, deficient in gamma-type repair were shown to be resistant to gamma-radiation after the vaccinia virus infection. In both cell lines there was a decrease in the number of the mutagen-induced DNA breaks.
authors: T A
authors: TA
authors: Sinel'shchikova
authors: E G
authors: EG
authors: Gubitskaia
authors: N B
authors: NB
authors: Akhmatullina
authors: G D
authors: GD
authors: Zasukhina
mesh_terms: D004247:DNA / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D005347:Fibroblasts / Q000187:drug effects / Q000382:microbiology / Q000528:radiation effects; D006712:Homocystinuria / Q000235:genetics / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D009153:Mutagens; D014616:Vaccinia virus
chemical_list: D009153:Mutagens; D004247:DNA
vernacular_title: Infitsirovanie reparativno-defektnykh kletok cheloveka virusom ospovaktsiny snizhaet formirovanie gamma-indutsirovannykh razryvov DNK.