Effect of inositol hexaphosphate on retention of zinc and calcium from the human colon.
Colonic retention of zinc and calcium was studied after installation during colonoscopy in 11 patients of a solution of 30 mumol zinc, 6.4 mmol calcium and 500 mumol inositol hexaphosphate (phytic acid) labelled with 65Zn and 47Ca. Whole-body retention of the radionuclide at day 13 was 1.0 +/- 1.0 per cent (mean +/- s.d.) for zinc and 4.0 +/- 2.9 per cent for calcium. The retention of zinc but not of calcium was lower than observed earlier under similar conditions from a solution not containing phytic acid and indicates formation of an indigestible complex between phytic acid and zinc. Addition of amino acids to the solution in 3 subjects did not seem to affect the retention of zinc and calcium.
Sandström
B
B
Research Department of Human Nutrition, Copenhagen, Denmark.
Cederblad
A
A
Stenquist
B
B
Andersson
H
H
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D003106:Colon / Q000378:metabolism*; D003113:Colonoscopy; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010833:Phytic Acid / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism*; D015037:Zinc Radioisotopes
D000596:Amino Acids; D002132:Calcium Radioisotopes; D015037:Zinc Radioisotopes; D010833:Phytic Acid; D015032:Zinc; D002118:Calcium