Epidermal growth factor receptor mRNA in livers from newborn, adult and partially hepatectomized rats.
Epidermal growth factor (EGF) receptor mRNA expression in livers of newborn, adult control and partially hepatectomized rats 1 and 3 days post-operation was examined by Northern blot analysis. A human EGF receptor cDNA (P 64-1, Ullrich et al., 1984) was hybridized to RNA species of 10, 6 and 3 kb. These mRNAs were profoundly decreased in livers from newborn rats and relatively decreased in regenerating rat livers. beta-Actin mRNA in these tissues showed a tendency to increase over that of the adult controls.
Satoh
Y
Y
Division of Physiology, Tottori University School of Medicine, Yonago, Japan.
Hoshikawa
Y
Y
Ichii
S
S
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D015152:Blotting, Northern; D066246:ErbB Receptors / Q000235:genetics*; D006498:Hepatectomy; D008099:Liver / Q000737:chemistry* / Q000254:growth & development / Q000502:physiology; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D012333:RNA, Messenger; D066246:ErbB Receptors