title: The interleukin-2 receptor on cord blood and nulliparous mononuclear cells is downregulated by maternal and cord blood serum.
abstract: The concentration of interleukin-2 receptor (IL-2R) on maternal, cord blood and unrelated nulliparous mononuclear cells has been studied after a previous phytohaemagglutinin (PHA) stimulation. Furthermore, the inhibitive action of maternal and cord blood serum on the IL-2R expression of stimulated nulliparous and cord blood lymphocytes has been shown. A downregulation of the [3H]-thymidine uptake by these PHA treated cells previously incubated in maternal and cord blood serum has been observed. Retroplacental serum was the most inhibitive experimental medium. The IL-2R modulation property of maternal serum has been studied during the pregnancy. Appearing quite early (in the sixth week), the maternal serum dependent inhibitive factor vanished, 2 to 3 weeks after delivery. After a study of the different serum components, it is suggested that the IL-2R downregulating molecule is included in the maternal immunoglobulin (IgG) fraction. Further experiments suggest that the addition of recombinant IL-2 during the action of low doses of maternal IgG allows a partial re-expression of the IL-2R. However, at physiological concentrations of IgG, the IL-2R downregulation becomes irreversible.
authors: Department of Immunology, Hospital St. Pierre, Rue Haute-Brussels, Belgium.
authors: Y E
authors: YE
authors: Vanderbeeken
authors: J
authors: J
authors: Duchateau
authors: L
authors: L
authors: Van Boogaert
authors: P
authors: P
authors: Desseilles
authors: H
authors: H
authors: Collet
authors: A
authors: A
authors: Lucas
mesh_terms: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood / Q000378:metabolism* / Q000502:physiology; D005434:Flow Cytometry; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011458:Prostaglandins E / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007074:Immunoglobulin G; D007376:Interleukin-2; D010835:Phytohemagglutinins; D011458:Prostaglandins E; D015375:Receptors, Interleukin-2; D013936:Thymidine