Systemic, pulmonary and renal haemodynamic and renal morphologic effects of intravenously infused iodixanol. A study in the pig of a new iso-osmolar contrast medium.
The systemic, pulmonary and renal haemodynamic effects following an intravenous infusion (1 ml/s, 4 ml/kg) of a non-ionic isoosmolar contrast medium (iodixanol) were investigated in 8 pigs. Histopathologic changes occurring after infusion of iodixanol were studied by repeated renal biopsies. Iodixanol caused a significant increase of cardiac output, mean right atrial pressure, mean pulmonary arterial pressure, mean pulmonary arterial occlusion pressure and mean arterial pressure. There was a decrease of the systemic and pulmonary vascular resistances. Most renal biopsies showed no pathologic findings after infusion of iodixanol but in 3 specimens proteinaceous content was observed 15 min after infusion.
Sunnegårdh
O
O
Department of Diagnostic Radiology, University Hospital of Umeå, Sweden.
Hietala
S O
SO
Holtz
E
E
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D009994:Osmolar Concentration; D011651:Pulmonary Artery / Q000502:physiology; D013552:Swine; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D014283:Triiodobenzoic Acids; C044834:iodixanol