title: [A neuron-specific enolase (NSE) positive leiomyosarcoma].
abstract: A 40-year-old woman with multiple skin tumors was admitted to our hospital on September 5, 1989. Extensive studies by means of light and electron-microscopic examination and immunohistochemical analysis revealed a neuron-specific enolase (NSE) positive leiomyosarcoma. The level of her elevated serum NSE decreased after receiving her initial chemotherapy, but after the fourth session of chemotherapy, the NSE began to elevate again and she died on December 25, 1989. NSE appears to be a useful marker for determining if the neuronal and neuroendocrine cells are normal. This rare case, however, seems to demonstrate that abnormal, nonneuronal cells like a sarcoma also open metabolic pathways to synthesize NSE.
authors: Dept. of Internal Med., Kakogawa Municipal Hospital.
authors: H
authors: H
authors: Ueno
authors: M
authors: M
authors: Asami
authors: R
authors: R
authors: Yoneda
authors: M
authors: M
authors: Ogura
authors: A
authors: A
authors: Muraoka
authors: T
authors: T
authors: Oribe
authors: K
authors: K
authors: Suzuki
authors: M
authors: M
authors: Maeda
authors: T
authors: T
authors: Chinzei
authors: K
authors: K
authors: Yamashiro
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000201:enzymology* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase