Secondary metabolites by chemical screening: II. Amycins A and B two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin.
Two novel natural niphimycin analogs, amycins A (5) and B (3) were isolated from the culture broth of the Streptomyces sp. DSM 3816 by chemical screening methods. In addition this strain produces the antibiotics niphimycin (4), elaiophylin (2) and nigericin (1). Fermentation, isolation, structure elucidation and biological activity of the amycins are described.
Grabley
S
S
Hoechst Aktiengesellschaft, Frankfurt a.M., FRG.
Hammann
P
P
Raether
W
W
Wink
J
J
Zeeck
A
A
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006146:Guanidines / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D009550:Nigericin / Q000096:biosynthesis; D013302:Streptomyces / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006146:Guanidines; D018942:Macrolides; C065212:amycin A; C010492:niphimycin; C065213:amycin B; C033279:elaiophylin; D009550:Nigericin