Evidence that use of Triton WR1339 underestimates the triacylglycerol entry rate into the plasma of lactating rats owing to continued accumulation of lipid in the mammary gland.
Measurement of the entry rate of an intragastric load of [14C]triolein into the plasma in the presence of Triton WR1339 gave similar values for virgin and weaned rats, but significantly lower values for lactating rats. This decreased entry rate (65%) in lactating compared with virgin rats was due to a failure of Triton WR1339 to inhibit the accumulation of [14C]lipid in the mammary gland. This is further evidence that mammary-gland lipoprotein lipase behaves differently from that in white adipose tissue or muscle.
Tedstone
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Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
Ilic
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Williamson
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D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D007774:Lactation / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014304:Triolein / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003902:Detergents; D014304:Triolein; D011092:Polyethylene Glycols; C016811:tyloxapol