[The effect of granulocyte-macrophage colony-stimulating factor on hemopoiesis recovery and the survival of irradiated mice].
A human recombinant granulocytic-and-macrophagic colony-stimulating factor (rGM-CSF) administered repeatedly to irradiated (10 Gy) CBA mice increased CFUs and CFU-GM content, the number of bone marrow granulocytes and erythronormoblasts, and spleen and peripheral blood cellularity. The survival rate of exposed (9.7 Gy) mice repeatedly injected with rGM-CSF increased from 25% (control) to 90%.
Rogacheva
S A
SA
Luzanov
V M
VM
Kirillova
E N
EN
Baranov
A E
AE
Muksinova
K N
KN
D000818:Animals; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011994:Recombinant Proteins; D013268:Stimulation, Chemical
D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
Vliianie rekombinantnogo granulotsitarno-makrofagal'nogo koloniestimuliruiushchego faktora na vosstanovlenie krovetvoreniia i vyzhivaemost' obluchennykh mysheĭ.