A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.
A current generated by the Na-activated K channel has been identified in whole cell currents recorded from isolated guinea-pig ventricular myocytes. A partial activation of this current can be achieved near to the physiological range of intracellular sodium concentration [( Na+]i) when it contributes significantly to the global outward current. The decline of the Na-activated K current, the lengthening of the action potential duration and the recovery of [Na+]i occur with a similar time course during recovery from Na loading.
Rodrigo
G C
GC
Department of Physiology, School of Veterinary Science, Bristol.
Chapman
R A
RA
D000200:Action Potentials; D000818:Animals; D052160:Benzothiazoles; D002118:Calcium / Q000502:physiology; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*; D066298:In Vitro Techniques; D008274:Magnesium; D010880:Piperidines; D015221:Potassium Channels / Q000502:physiology*; D012964:Sodium / Q000502:physiology*; D013844:Thiazoles
D052160:Benzothiazoles; D010880:Piperidines; D015221:Potassium Channels; D013844:Thiazoles; C054551:R 56865; D012964:Sodium; D008274:Magnesium; D002118:Calcium