[Urine excretion of PGE2, PGF2 alpha in patients with deficiency-cold syndrome and deficiency-heat syndrome].
The 3 hours' urine excretion of PGE2 and PGF2 alpha in 32 patients and 19 healthy persons were determined by RIA. According to TCM, the patients were divided into two groups: 17 cases of deficiency-cold syndrome and 15 cases of deficiency-heat syndrome. The result showed that in patients with deficiency-cold syndrome, the excretion of urine PGE2 was lower than that of the normal control (P less than 0.05), while the excretion of urine PGF2 alpha higher than that of the normal control (P less than 0.01) and hence the PGE2/PGF2 alpha ratio was much lower (P less than 0.01); in those with deficiency-heat syndrome, the excretion of urine PGE2 was higher (P less than 0.01), the excretion of urine PGF2 alpha had no significant change (P greater than 0.05) from the normal, and the PGE2/PGF2 alpha ratio was higher (P less than 0.01). The above result indicates a close relationship between prostaglandins and the cold and heat nature of syndromes in TCM. In connection with our previous studies that showed decreased functioning of the sympathetic-adrenomedullary system and/or increased functioning of the parasympathetic nervous system with diminished catecholamines and reduced cAMP/cGMP ratio in deficiency-cold syndrome while increased functioning of the sympathetic-adrenomedullary system with augmented catecholamines and cAMP in deficiency-heat syndrome, the change of prostaglandins level can be considered as an intermediate link in the pathogenesis of syndromes different in cold and heat nature.
Guo
Y G
YG
Institute of Integration of Traditional and Western Medicine, First Hospital of Beijing Medical University.
Xie
Z F
ZF
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000652:urine*; D003080:Cold Temperature; D015237:Dinoprost / Q000652:urine*; D015232:Dinoprostone / Q000652:urine*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D013577:Syndrome
D015237:Dinoprost; D015232:Dinoprostone