[Fever caused by fipexide. Evaluation of the national pharmacovigilance survey].
Fourteen cases of drug fever due to fipexide were reported by a retrospective survey of a National Network of French Pharmacovigilance. 8 women, 6 men (mean age, 52 years), presented a sudden fever with a mean onset delay of 7 days after the first cure (range 2-12 days). In five cases, drug fever was the only manifestation; in other cases, it was associated with systemic or cutaneous signs. Eosinophilia was frequent (8 cases) and once, a chest picture showed an interstitial pneumonitis. Fever disappeared promptly after discontinuation of the drug and for ten patients, the rechallenge was positive within a short time. The clinical picture and laboratory tests are discussed and suggest an hypersensitivity reaction.
Guy
C
C
Centre Régional de Pharmacovigilance, Hôpital de Bellevue, Saint-Etienne.
Blay
N
N
Rousset
H
H
Fardeau
V
V
Ollagnier
M
M
D000328:Adult; D000368:Aged; D005260:Female; D005334:Fever / Q000139:chemically induced*; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects*; D011358:Product Surveillance, Postmarketing; D012189:Retrospective Studies
D010879:Piperazines; C038628:fipexide
Les fièvres au fipexide. Bilan de l'enquête nationale de pharmacovigilance.