ski can cause selective growth of skeletal muscle in transgenic mice.
We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line.
Sutrave
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National Cancer Institute-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Maryland 21701-1013.
Kelly
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Hughes
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D000818:Animals; D002645:Chickens; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D006128:Growth / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008980:Moloney murine sarcoma virus / Q000235:genetics; D024510:Muscle Development; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; C512653:Ski protein, mouse