title: Clinical and laboratory features of a severe form of von Willebrand disease in Shetland sheepdogs.
abstract: Ten clinically affected Shetland Sheepdogs were evaluated to define their severe bleeding diathesis and were determined to have von Willebrand factor antigen (vWF:Ag) values less than 0.1% by ELISA assay. The virtual absence of vWF protein by ELISA assay and on multimeric analysis was diagnostic of either homozygosity or probable double heterozygosity for the canine von Willebrand disease (vWD) gene. Clinically affected dogs have type-III vWD and are the offspring of 2 heterozygous parents carrying type-I vWD. Twenty-three percent (1,428 dogs) of the more than 6,000 Shetland Sheepdogs screened for vWD at our facility since 1982 tested within the heterozygous carrier range for the common type-I form of this inherited disorder. Veterinarians and breeders should be aware of the potential for bleeding associated with elective and medical procedures in Shetland Sheepdogs and should use caution when breeding carriers of vWD because of the risk of producing clinically affected offspring with severe type-III vWD.
authors: Wadsworth Center for Laboratories & Research, New York State Department of Health, Albany 12201-0509.
authors: S L
authors: SL
authors: Raymond
authors: D W
authors: DW
authors: Jones
authors: M B
authors: MB
authors: Brooks
authors: W J
authors: WJ
authors: Dodds
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests; D001947:Breeding; D004283:Dog Diseases / Q000097:blood* / Q000235:genetics; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008297:Male; D010375:Pedigree; D010974:Platelet Aggregation; D014842:von Willebrand Diseases / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor