[The neurochemical characteristics of the effect of morphine and pentapeptide FK 33-824 on cerebral cortical excitability].
GABA-stimulating agents (muscimol, depakine, aminohydroxyacetic acid), serotonin stimulants (5-hydroxytryptophan, fluoxetine), catecholaminergic stimulants (L-DOPA, apomorphine) and a cholinergic inhibitor (hemicholinium-3) of the brain were found to enhance the inhibitory effect of morphine and pentapeptide FK 33-824 on the cortical excitability of free-moving cats. GABA-negative agents (thiosemicarbazide, bicuculline, picrotoxin), serotonin-negative agents (p-chlorophenylalanine, methysergide), catecholaminergic inhibitors (6-hydroxydopamine, alpha-methyl-p-tyrosine) and cholinergic stimulant (physostigmine) of the brain appeared to decrease the effects of morphine and pentapeptide FK 33-824 on the excitability of the cortex. beta-adrenoceptor blocker propranolol decreased the effects of morphine and pentapeptide FK 33-824 on the cortical excitability, whereas alpha-adrenoblockers (phentolamine, phenoxybenzamine and yochimbine) exerted no effect on their action.
Fisenko
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D000818:Animals; D002415:Cats; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D009020:Morphine / Q000494:pharmacology*; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D009020:Morphine
Ob neĭrokhimicheskikh osobennostiakh deĭstviia morfina i pentapeptida FK 33-824 na vozbudimost' kory golovnogo mozga.