[Infection of repair-deficient human cells by the vaccinia virus decreases the formation of gamma-induced DNA breaks].
The alkaline elution method was used to study DNA breaks induced by the different mutagens in human cells. Normal fibroblasts and fibroblasts from patients with homocystinuria, deficient in gamma-type repair were shown to be resistant to gamma-radiation after the vaccinia virus infection. In both cell lines there was a decrease in the number of the mutagen-induced DNA breaks.
Sinel'shchikova
T A
TA
Gubitskaia
E G
EG
Akhmatullina
N B
NB
Zasukhina
G D
GD
D004247:DNA / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D005347:Fibroblasts / Q000187:drug effects / Q000382:microbiology / Q000528:radiation effects; D006712:Homocystinuria / Q000235:genetics / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D009153:Mutagens; D014616:Vaccinia virus
D009153:Mutagens; D004247:DNA
Infitsirovanie reparativno-defektnykh kletok cheloveka virusom ospovaktsiny snizhaet formirovanie gamma-indutsirovannykh razryvov DNK.