Preformulation studies on suppositories by thermal methods.
The application of differential scanning calorimetry (DSC) is described for investigating the interaction between trimethoprim and sulfamethoxypyridazine in suppository formulations containing fat bases (Suppocire, Novata, Witepsol). The thermal behavior of suppositories at various storage times is deeply influenced by the fat base and by interaction between active ingredients. Liquefaction time and dropping temperature were also evaluated for comparison and control purposes.
Giordano
F
F
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italia.
La Manna
A
A
Bettinetti
G P
GP
Zamparutti
M
M
D002152:Calorimetry, Differential Scanning; D013421:Sulfamethoxypyridazine / Q000032:analysis; D013488:Suppositories / Q000032:analysis*; D014295:Trimethoprim / Q000032:analysis
D013488:Suppositories; D014295:Trimethoprim; D013421:Sulfamethoxypyridazine