title: Low threshold calcium spikes in medial vestibular nuclei neurones in vitro: a role in the generation of the vestibular nystagmus quick phase in vivo?
abstract: Intracellular recordings were obtained from medial vestibular nuclei neurones in guinea-pig brainstem slices. A subpopulation of neurones in this nucleus was found to have burst firing properties. Using ionic channel blockers the underlying mechanism was shown to be a low threshold calcium spike. It is speculated that this property could be implicated in the generation of the quick phase of the vestibular nystagmus in the behaving guinea-pig.
authors: Département de Physiologie, CMU, Genève, Switzerland.
authors: M
authors: M
authors: Serafin
authors: A
authors: A
authors: Khateb
authors: C
authors: C
authors: de Waele
authors: P P
authors: PP
authors: Vidal
authors: M
authors: M
authors: Mühlethaler
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000502:physiology; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009760:Nystagmus, Physiologic / Q000502:physiology*; D009799:Ocular Physiological Phenomena; D012018:Reflex / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology; D013788:Thalamus / Q000166:cytology / Q000502:physiology; D014726:Vestibular Nuclei / Q000166:cytology / Q000502:physiology*
chemical_list: D002121:Calcium Channel Blockers; D013779:Tetrodotoxin; D002118:Calcium