The role of periaqueductal gray in mediation of analgesia produced by different frequencies electroacupuncture stimulation in rats.
The marked suppression of noxious heat-evoked tail flick reflex was produced in conscious rats by low (2 Hz) or high (100 Hz) frequency electroacupuncture (EA) stimulation at acupoints S36 and Sp6. Electrolytic and kainate lesions in the ventral periaqueductal gray (vPAG) led to significant attenuation of the low and high frequency EA analgesia as measured 4 and 6 days following the lesion. In sham-operated animals, analgesia induced by either low or high frequency EA remained intact. The role of vPAG in organization of different EA analgesia is discussed in detail.
Wang
Q A
QA
Department of Physiology, Beijing Medical University, People's Republic of China.
Mao
L M
LM
Han
J S
JS
D000698:Analgesia; D000818:Animals; D004558:Electric Stimulation; D015671:Electroacupuncture; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology; D010147:Pain Measurement; D010487:Periaqueductal Gray / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D007608:Kainic Acid