Oral senile amyloidosis in senescence accelerated mouse (SAM).
Oral senile amyloidosis in senescence accelerated mouse (SAM) was examined for two SAM sublines (P/2/Iw and R/1/Iw) and for various ages by light microscopy, immunohistochemistry, and electron microscopy. The amyloid deposition, identified by green birefrigence following Congo red stain, was observed only in P/2/Iw. In P/2/Iw, no amyloid deposition was found at age 6 months; however, frequency and extent of such deposits increased with advancing age. Distribution of amyloid deposition was as follows: along papillary layers of mucous epithelium in the tongue, the gingiva, the palate, and the buccal mucosa; foci in connective tissues; along vessels, muscles, and minor salivary glands. Immunohistochemically, the amyloid deposition was positive with anti-ASSAM serum being raised against a unique amyloid protein ASSAM which probably induced "senile systemic amyloidosis". P/2/Iw is useful as an animal model of oral senile amyloidosis.
Sashima
M
M
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.
Satoh
M
M
Suzuki
A
A
D000375:Aging / Q000502:physiology; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005881:Gingiva / Q000737:chemistry / Q000648:ultrastructure; D007150:Immunohistochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000737:chemistry / Q000648:ultrastructure; D010159:Palate / Q000737:chemistry / Q000648:ultrastructure; D014059:Tongue / Q000737:chemistry / Q000648:ultrastructure
D000682:Amyloid