title: Molecular epidemiology and cancer prevention.
abstract: A review of recent studies of biologic markers in populations with model exposures to carcinogens (cigarette smoke and polycyclic aromatic hydrocarbons) illustrates their potential role in cancer prevention. Data on macromolecular adducts and oncogene activation from cross-sectional, serial sampling and case-control studies demonstrate the usefulness of biologic markers in signalling a potential carcinogenic risk and in estimating the magnitude of interindividual variation within exposed groups. Recommendations for future research include nested case-control studies to establish the relationship between markers of biologic dose and effect (e.g., adducts, gene mutation, oncogene activation) and cancer risk.
authors: Columbia University School of Public Health, Division of Environmental Sciences, New York, NY 10032.
authors: F P
authors: FP
authors: Perera
authors: A M
authors: AM
authors: Jeffrey
authors: P W
authors: PW
authors: Brandt-Rauf
authors: D
authors: D
authors: Brenner
authors: J L
authors: JL
authors: Mayer
authors: S J
authors: SJ
authors: Smith
authors: L
authors: L
authors: Latriano
authors: K
authors: K
authors: Hemminki
authors: R M
authors: RM
authors: Santella
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D015415:Biomarkers / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D004812:Epidemiologic Methods; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm