[Apolipoprotein E phenotypes and psoriasis].
Using gel isoelectric focusing method, we determine the frequencies of  apoE isoform and gene of 32 patiens with psoriasis vulgaris. The patients showed higher frequencies of E3/3 and the allele epsilon 2 and lower frequencies of E3/3 and the allele epsilon 3 than the healthy Japanese control. The tendency to have higher frequencies of E3/2 and epsilon 2 was more apparent in the patients of early onset than of late onset, with severe type than with mild or moderate type, and of universal form of plaque type eruption and guttate form than of localized form of plaque type eruption. These differences fell short of statistical significance. These findings suggest us an important role of apoE2 (allele epsilon 2) over the onset and the clinical severity of psoriasis vulgaris.
Imamura
T
T
Department of Dermatology, Yamaguchi University School of Medicine.
Takata
I
I
Tominaga
K
K
Yamamoto
T
T
Ogasawara
M
M
Asagami
C
C
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011565:Psoriasis / Q000235:genetics*
D001057:Apolipoproteins E