Elevated serum concentrations of IgE antibodies to environmental antigens in HIV-seropositive male homosexuals.
Forty-five homosexual male subjects with human immunodeficiency virus (HIV) infection, who received care during a 4-month period in an ambulatory center for acquired immunodeficiency syndrome (AIDS), were classified according to their principal presentation with characteristic secondary infections (CDC group IV C, N = 28), cancers (IV D, N = 10), or limited or no symptoms (groups II, III, IV A, or IV B, N = 7). The incidence of allergic rhinitis and conjunctivitis increased after HIV seroconversion by approximately twofold in patients of groups IV C and IV D. The mean serum concentration of IgE was significantly higher for group IV C than for the other HIV-seropositive groups and for a control group of 45 HIV-seronegative homosexual male subjects from the same community who were studied concurrently. More patients in groups IV C and IV D had positive RASTs for a panel of environmental antigens than patients in the other HIV-seropositive groups and the HIV-seronegative control group. Patients with AIDS presenting with typical secondary infections thus have a high frequency of some clinical and laboratory manifestations of allergic diseases.
Sample
S
S
Department of Medicine, University of California Medical Center, San Francisco.
Chernoff
D N
DN
Lenahan
G A
GA
Serwonska
M H
MH
Rangi
S
S
Sherman
J W
JW
Sooy
C D
CD
Hollander
H
H
Goetzl
E J
EJ
D000386:AIDS-Related Complex / Q000150:complications; D000906:Antibodies / Q000032:analysis*; D003233:Conjunctivitis, Allergic / Q000150:complications; D004777:Environment; D006679:HIV Seropositivity / Q000097:blood / Q000145:classification / Q000150:complications / Q000276:immunology*; D006716:Homosexuality; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D009369:Neoplasms / Q000150:complications; D009422:Nervous System Diseases / Q000150:complications; D009994:Osmolar Concentration; D012220:Rhinitis / Q000150:complications
D000906:Antibodies; D007073:Immunoglobulin E