Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function.
The human neuroblastoma cell line, SH-SY5Y, differentiates into neuron-like cells according to morphological, biochemical and functional criteria when treated with biologically active phorbol-esters. The differentiated phenotype is described and alterations in proto-oncogene expression in connection with growth control and differentiation are presented and discussed.
Påhlman
S
S
Department of Pathology, University Hospital, University of Uppsala, Sweden.
Mamaeva
S
S
Meyerson
G
G
Mattsson
M E
ME
Bjelfman
C
C
Ortoft
E
E
Hammerling
U
U
D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009447:Neuroblastoma / Q000473:pathology*; D009474:Neurons / Q000502:physiology*; D000090063:Proto-Oncogene Mas; D014407:Tumor Cells, Cultured / Q000473:pathology*