Study of the gametocytocidal/sporontocidal action of qinghaosu (artemisinin) by electron microscopy.
The gametocytocidal efficacy of artemisinin (qinghaosu) was evaluated and scanning electron microscopical evidence is given for gametocytocidal action of a single 5-10-mg/kg dose of artemisinin against simian malarial parasite (Plasmodium cynomolgi B). No sporontocidal effect of artemisinin was observed.
Dutta
G P
GP
Division of Microbiology, Central Drug Research Institute, Lucknow, India.
Mohan
A
A
Tripathi
R
R
D000818:Animals; D000852:Anopheles; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008855:Microscopy, Electron, Scanning; D010961:Plasmodium / Q000187:drug effects* / Q000648:ultrastructure; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*
D000962:Antimalarials; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C031327:artemisinin