title: Influence of aging on ethanol and acetaldehyde oxidation in female rat liver.
abstract: Rates of ethanol metabolism by alcohol dehydrogenase, the microsomal ethanol oxidizing system (MEOS), and catalase were similar in liver preparations from young (4-5 months) and old (24-27 months) female Fischer 344 rats. On the other hand, rates of acetaldehyde metabolism by mitochondrial aldehyde dehydrogenase (ALDH) were 15-20% lower in livers of old rats than in those of younger ones. Results with the ALDH inhibitor cyanamide indicated that a decline in ALDH activity of this magnitude would not increase acute ethanol hepatotoxicity.
authors: Department of Pharmacology, University of Oklahoma College of Medicine, Oklahoma City.
authors: L E
authors: LE
authors: Rikans
authors: C D
authors: CD
authors: Snowden
authors: D R
authors: DR
authors: Moore
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003484:Cyanamide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000431:Ethanol; D003484:Cyanamide; D003577:Cytochrome P-450 Enzyme System; D000429:Alcohol Oxidoreductases; C092153:microsomal ethanol-oxidizing system; D000426:Alcohol Dehydrogenase; C019642:alcohol dehydrogenase (NADP+); D002374:Catalase; D000444:Aldehyde Dehydrogenase; D005969:Glutamate Dehydrogenase; D000079:Acetaldehyde