Localization of human cardiac beta-myosin heavy chain gene (MYH7) to chromosome 14q12 by in situ hybridization.
The genes coding for each human cardiac myosin heavy chain (alpha-MHC and beta-MHC, MYH6 and MYH7, respectively) are tightly linked and the alpha-MHC gene has been assigned to chromosome 14. In order to provide a more precise regional localization, in situ hybridization experiments were carried out using a 3H-labeled probe derived from a beta-MHC genomic clone. The results demonstrated that the human cardiac MHC genes are located within the q12 band of chromosome 14.
Qin
H
H
Department of Physiology, University of Sydney, N.S.W., Australia.
Kemp
J
J
Yip
M Y
MY
Lam-Po-Tang
P R
PR
Hoh
J F
JF
Morris
B J
BJ
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D009206:Myocardium / Q000737:chemistry*; D009218:Myosins / Q000235:genetics*
D009218:Myosins