Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection.
We evaluated cerebrospinal fluid (CSF) concentrations of neopterin, a putative marker of activated macrophages, in 97 subjects infected with human immunodeficiency virus type 1 who had a spectrum of neurological complications. The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS) dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood-brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. These results suggest that CSF neopterin, although not disease-specific, may be useful as a surrogate marker for the presence of AIDS dementia complex and its response to antiviral therapy.
Brew
B J
BJ
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.
Bhalla
R B
RB
Paul
M
M
Gallardo
H
H
McArthur
J C
JC
Schwartz
M K
MK
Price
R W
RW
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001708:Biopterins / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000209:etiology; D015331:Cohort Studies; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000150:complications; D015497:HIV-1; D006261:Headache / Q000134:cerebrospinal fluid / Q000150:complications; D006801:Humans; D007111:Immunity, Cellular; D008223:Lymphoma / Q000134:cerebrospinal fluid / Q000209:etiology; D019798:Neopterin; D009894:Opportunistic Infections / Q000134:cerebrospinal fluid / Q000150:complications
D015415:Biomarkers; D001708:Biopterins; D019798:Neopterin