Physical and chemical factors influencing the release of drugs from acrylic resin films.
An investigation was conducted to evaluate the factors influencing the release of salicylic acid and chlorpheniramine maleate from polymethacrylate amino-ester copolymer films (Eudragits RL PM and RS PM). Differential scanning calorimetry was performed on the films to study the solubility of drug in the polymer and to determine the effect of added drug on the thermal properties of the film. Incorporation of drug into the polymers decreased the glass transition temperature of the polymers. Dissolution of drug from monolithic slabs was followed as a function of temperature, drug concentration in the films, and ionic strength of the release media. In addition, adsorption studies were conducted with each drug:polymer combination to help explain release results and further characterize the drug:polymer interactions that occurred. The rate of drug release increased with increasing temperature. Adsorption of salicylic acid by the polymers was believed to influence the drug release profiles observed for different drug loadings and ionic strengths. Eudragit RL was found to adsorb salicylic acid to a greater extent than the Eudragit RS. Chlorpheniramine maleate was not found to be adsorbed by either polymer.
Jenquin
M R
MR
College of Pharmacy, University of Texas, Austin 78712.
Liebowitz
S M
SM
Sarabia
R E
RE
McGinity
J W
JW
D000179:Acrylates; D000327:Adsorption; D002626:Chemistry, Pharmaceutical; D002744:Chlorpheniramine / Q000737:chemistry; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers; D011109:Polymethacrylic Acids; D012116:Resins, Plant; D012459:Salicylates / Q000737:chemistry; D020156:Salicylic Acid; D013696:Temperature
D000179:Acrylates; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D011108:Polymers; D011109:Polymethacrylic Acids; D012116:Resins, Plant; D012459:Salicylates; C038300:methylmethacrylate-methacrylic acid copolymer; D002744:Chlorpheniramine; D020156:Salicylic Acid