Genetics of 51D-52A, a region containing several maternal-effect genes and two maternal-specific transcripts in Drosophila.
Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-sterile and lethal mutations isolated. A total of twelve complementation groups have been identified, four of which are defined exclusively by female-sterile alleles. Only one visible mutation was isolated, a recessive temperature-sensitive allele of Thickened-arista (Tarts). Several of the seven lethal loci display an embryonic lethal phase. Three of the four female-sterile loci affect chorion structure with one resulting in underamplification of the chorion genes, and two (possibly three) of the four female-steriles affect nuclear division/DNA replication. Thus it appears that this is a "developmentally important" region, possibly representing a clustering of genes involved in either DNA replication or nuclear division.
Underwood
E M
EM
Department of Biological Sciences, Bowling Green State University, Ohio 43403.
Briot
A S
AS
Doll
K Z
KZ
Ludwiczak
R L
RL
Otteson
D C
DC
Tower
J
J
Vessey
K B
KB
Yu
K
K
D000483:Alleles; D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004330:Drosophila / Q000235:genetics*; D005260:Female; D005796:Genes; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D008297:Male; D016296:Mutagenesis; D009154:Mutation; D012098:Reproduction / Q000235:genetics; D013696:Temperature; D014158:Transcription, Genetic