Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats.
The oral hypoglycaemic activity of Momordica charantia fruit juice was investigated in rats with streptozotocin-induced diabetes. Oral administration of the juice (10 ml/kg for 30 days) did not show a significant effect, either acute or cumulative, on the ability to tolerate an external glucose load. The glycosylated haemoglobin concentrations were significantly elevated in both juice-treated and untreated diabetic rats and there was no significant difference between the two groups. Viable beta-cells capable of secreting insulin upon stimulation appear to be required for M. charantia to exert its oral hypoglycaemic activity.
Karunanayake
E H
EH
Department of Biochemistry, Faculty of Medicine, University of Colombo, Sri Lanka.
Jeevathayaparan
S
S
Tennekoon
K H
KH
D000284:Administration, Oral; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005638:Fruit; D005951:Glucose Tolerance Test; D006031:Glycosylation; D006454:Hemoglobins / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006454:Hemoglobins; D007328:Insulin; D010936:Plant Extracts