title: Population pharmacokinetics of phenytoin in Singapore Chinese.
abstract: The pharmacokinetics of phenytoin was studied in 66 epileptic Chinese children and adults. The data were analysed by the population approach, using the non-linear mixed effect model, in the MULTI (ELS) program. There was no age or gender-related effect on either the apparent maximum elimination rate (kmax) or Michaelis-Menten constant (KM). Kmax was related to body weight 0.656. The population pharmacokinetics was similar in children and adults. Kmax and KM were estimated to be 30.72 mg.kg-0.656 day-1 and 2.307 mg.l-1, respectively. Kmax was higher than reported values, and KM was comparable to that reported in a study in Japanese, but was much lower than that reported in studies of European patients. The inter-individual variability of KM (CV 65.58%) was substantially higher than that of kmax (CV 28.49%), and the residual (intra-individual) variability was found 21.33% (CV).
authors: Department of Pharmacy, National University of Singapore.
authors: E
authors: E
authors: Chan
authors: T Y
authors: TY
authors: Ti
authors: H S
authors: HS
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D001499:Bayes Theorem; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000493:pharmacokinetics*; D012044:Regression Analysis; D012737:Sex Factors; D012846:Singapore
chemical_list: D010672:Phenytoin