Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor (BMRR).
NCT is a binary system, in which 10B is physiologically targeted to tumor and then allowed to interact with thermal neutrons generated in the treatment volume by an externally applied neutron beam. Consequently, an unusually large number of parameters are obtained, which bear on the resultant Therapeutic Gain (TG). However, a perusal of these data, as illustrated in Figure 7, indicates that the TG would increase significantly beyond values projected in this paper if the absolute amount of 10B could be increased above 30 ppm. For example, increasing 10B concentration in tumor to 45 ppm would increase TG by approximately 33% (with a T/N of 5). A similar increase in TG would follow an increase in T/N from 5 to 10. Those associated with the development of boron compounds for NCT feel that such developments are within reach.
Fairchild
R G
RG
Medical Department, Brookhaven National Laboratory, Upton, NY.
Kalef-Ezra
J
J
Saraf
S K
SK
Fiarman
S
S
Ramsey
E
E
Wielopolski
L
L
Laster
B H
BH
Wheeler
F J
FJ
D001896:Boron Compounds / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy; D005160:Facility Design and Construction; D006801:Humans; D008961:Models, Structural; D009502:Neutrons / Q000627:therapeutic use*; D009688:Nuclear Reactors / Q000295:instrumentation*; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage
D001896:Boron Compounds; D011838:Radiation-Sensitizing Agents