[Effect of si jun zi tang on the macrophage cytotoxic activity in mice].
The effect of Si Jun Zi Tang (SJZT) on the activities of peritoneal macrophage (M phi) mediated MTC and ADCC in normal and immunosuppressed mice were examined by isotope releasing assay (51Cr, 125I-UdR). The results showed the SJZT no significantly increased peritoneal M phi-mediated cytotoxic activity (MTC, ADCC) in normal mice. After the injection of immuno-depressive cyclophosphamide (Cy) alone (ip), the cytotoxic activities were decreased, but by treatment with Cy and SJZT, the cytotoxic activities were significantly increased compared with Cy group, the enhancing rates amounted to 74.40% (M phi-MTC) and 121.03% (M phi-ADCC) respectively. It was demonstrated that the SJZT could protest against the effect that the Cy inhibited the activities of MTC and ADCC of peritoneal M phi in mice, but there was no significant effect on normal mice. It indicated that the function of SJZT's immunoregulation was related to the state of immune in body.
Dou
J
J
Dept. of Microbiology, Wannan Medical College, Wuhu.
Wu
M Y
MY
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D003520:Cyclophosphamide / Q000009:adverse effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology*
D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide