title: Evidence that use of Triton WR1339 underestimates the triacylglycerol entry rate into the plasma of lactating rats owing to continued accumulation of lipid in the mammary gland.
abstract: Measurement of the entry rate of an intragastric load of [14C]triolein into the plasma in the presence of Triton WR1339 gave similar values for virgin and weaned rats, but significantly lower values for lactating rats. This decreased entry rate (65%) in lactating compared with virgin rats was due to a failure of Triton WR1339 to inhibit the accumulation of [14C]lipid in the mammary gland. This is further evidence that mammary-gland lipoprotein lipase behaves differently from that in white adipose tissue or muscle.
authors: Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
authors: A E
authors: AE
authors: Tedstone
authors: V
authors: V
authors: Ilic
authors: D H
authors: DH
authors: Williamson
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D007774:Lactation / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014304:Triolein / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D003902:Detergents; D014304:Triolein; D011092:Polyethylene Glycols; C016811:tyloxapol