[Hemolytic disease of the newborn caused by maternal irregular antibody anti-E: report of one case].
A 3390 gm male baby was born smoothly at 41 weeks' gestation to a 35-year-old, gravida 3, para 3, mother by spontaneous vaginal delivery at this hospital. The mother denied ever having received a blood transfusion. Her first two uneventful pregnancies had resulted in two healthy fullterm infants. Physical examination of the baby showed normal, until 15 hours of age, when apparent jaundice with serum total bilirubin concentration up to 21 mg/dl was noted. The blood types of both baby and mother were group A, Rh(D) positive. Compatibility testing for exchange blood transfusion with group A whole blood showed positive reaction due to the presence of an irregular antibody. Two exchange blood transfusions were performed in the same day with compatible blood. Thereafter, the patient's condition was much improved, he was discharged one week later. The irregular antibody--anti-E was identified in both baby and mother. The maternal RBC phenotyping was CCDee (R1R1), and the baby, CcDEe (R1R2).
Liu
Y J
YJ
Department of Pediatrics, Taipei Municipal Chung-Hsiao Hospital, Taiwan, R.O.C.
Lee
B F
BF
Lin
Y Z
YZ
Chen
W
W
Wu
K W
KW
Lin
M C
MC
D001789:Blood Group Antigens / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000378:metabolism*; D008297:Male; D009035:Mothers
D001789:Blood Group Antigens; D007518:Isoantibodies