title: Therapeutic possibilities of 131I-MIBG in metastatic carcinoid tumors--preliminary report.
abstract: The poor results of traditional therapy in advanced carcinoid tumors and the well-proven uptake of 131I-MIBG shown by some of these tumors induced us to attempt a radiometabolic approach. We selected for the treatment 5 patients (3 men and 2 women) who showed progression of disease, a fairly good uptake of 131I-MIBG with severe related symptoms, and a poor response to traditional therapy. A cumulative radioactivity of 5.5-29.6 GBq was given. Acute side effects after 131I-MIBG administration or late radiation-induced damages were not observed. Symptoms increased during the first 2-4 weeks in 2 patients: in one of these relief was achieved with drugs. Results concerning objective remission of the disease were unsatisfactory. In contrast, definite improvement of symptoms was shown in 2 of 5 patients, resulting in a better quality of life.
authors: Servizio Medicina Nucleare, Spedali Civili, Brescia, Italy.
authors: P
authors: P
authors: Guerra
authors: L
authors: L
authors: Colombo
authors: G
authors: G
authors: Maira
authors: R
authors: R
authors: Pagliaini
authors: A
authors: A
authors: Terzi
authors: C
authors: C
authors: Pizzocaro
authors: M E
authors: ME
authors: Dottorini
authors: G
authors: G
authors: Lomuscio
authors: M
authors: M
authors: Bestagno
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D002276:Carcinoid Tumor / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine