Polyglucosan bodies in sural nerve biopsies.
The presence of polyglucosan bodies in sural nerves collected over a 16-year period was studied in relation to age, sex, presence of polyneuropathy, and concomitant presence of central nervous system disorder. Polyglucosan bodies have been seen in only one patient without a polyneuropathy. This patient was suffering from Lafora's disease. In all other sural nerves positive for polyglucosan bodies a polyneuropathy was present. Within this group the prevalence of polyglucosan bodies was positively correlated with age, and if a central nervous system disorder was associated, this prevalence was more distinct. With semiquantitative measurements of the surface of polyglucosan bodies a significant correlation was found between age and percentage of large bodies.
Busard
H L
HL
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
Gabreëls-Festen
A A
AA
van 't Hof
M A
MA
Renier
W O
WO
Gabreëls
F J
FJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005936:Glucans / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000473:pathology*; D012189:Retrospective Studies; D013497:Sural Nerve / Q000473:pathology*
D005936:Glucans