title: Prediction of water vapor transport rates across polyvinylchloride packaging systems using a novel radiotracer method.
abstract: A radiotracer method is used to study the transport properties of water vapor in polyvinylchloride (PVC), a plastic commonly used in the packaging of parenteral solutions. Water vapor transport across a PVC film appears to be Fickian in nature. Using the steady-state solution of Fick's second law and the permeability coefficient of water vapor across the PVC film obtained using the described method, the predicted water vapor transport rate (WVTR) for a parenteral solution packaged in PVC is in reasonable agreement with actual WVTR as determined by weight loss under precisely controlled conditions.
authors: Pharmaceutical R & D, Baxter Healthcare Corporation, Round Lake, Illinois.
authors: R W
authors: RW
authors: Wood
authors: M J
authors: MJ
authors: Mulski
authors: W Y
authors: WY
authors: Kuu
mesh_terms: D003903:Deuterium / Q000032:analysis*; D004058:Diffusion; D004349:Drug Packaging / Q000379:methods*; D004356:Drug Storage; D011143:Polyvinyl Chloride; D014867:Water / Q000032:analysis*
chemical_list: D014867:Water; D011143:Polyvinyl Chloride; D003903:Deuterium