title: Effect of captopril on glucose concentration. Possible role of augmented postprandial forearm blood flow.
abstract: The goal of this study was to evaluate the effects of captopril on plasma glucose concentration. The daily profiles of the plasma glucose levels were determined in 12 non-insulin-dependent diabetic normotensive subjects, treated with or without captopril at a dose of 25 mg 3 times/day. Forearm blood flow was also measured by strain-gauge plethysmography. Administration of captopril improved the daily profile of the plasma glucose level. Postprandial forearm blood flow was also augmented 2 h after a meal. These results suggest that angiotensin-converting enzyme inhibitors may improve glucose metabolism in diabetic subjects, possibly through enhancement of blood flow to skeletal muscle.
authors: Fourth Department of Medicine, Saitama Medical School, Japan.
authors: J
authors: J
authors: Kodama
authors: S
authors: S
authors: Katayama
authors: K
authors: K
authors: Tanaka
authors: A
authors: A
authors: Itabashi
authors: S
authors: S
authors: Kawazu
authors: J
authors: J
authors: Ishii
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004435:Eating; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D002216:Captopril