[Ectopic production of human chorionic gonadotropin by poorly differentiated transitional cell carcinoma of the renal pelvis].
Herein we report a case of ectopic production of hCG by poorly differentiated transitional cell tumor of the renal pelvis. The patient was a 55-year-old male who had been diagnosed at another hospital as having giant hydronephrosis and renal stones and was referred to our hospital. The plain abdominal CT showed a low-density mass at the lower pole of the right kidney. His serum hCG level was as high as 120 mIU/ml. Transperitoneal nephrectomy was performed on July 7, 1987. Histopathological examinations showed the presence of squamous metaplasia within a high-grade transitional cell carcinoma, and immunohistochemical studies revealed the presence of chorionic gonadotropin in some giant cells. Two courses of combination chemotherapy with methotrexate, vinblastine, adriamycin and cisplatin (M-VAC regimen) were given to him from the third week after the operation. However, he died of debility with distant metastasis 6 months after the operation. As far as we know, this is the third reported case in Japan.
Izumi
H
H
Department of Urology, Yokohama Dai-chi Hospital.
Kajiya
M
M
Chiba
T
T
Uchida
T
T
Hidai
H
H
Yukio
N
N
Ohaki
Y
Y
Misugi
K
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006729:Hormones, Ectopic / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006869:Hydronephrosis / Q000150:complications; D007124:Immunoenzyme Techniques; D007669:Kidney Calculi / Q000150:complications; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D007682:Kidney Pelvis; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009392:Nephrectomy; D014747:Vinblastine / Q000008:administration & dosage
D006063:Chorionic Gonadotropin; D006729:Hormones, Ectopic; D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate