title: Guided tissue regeneration following treatment of recession-type defects in the monkey.
abstract: Recent studies have demonstrated extensive amounts of new attachment formation following reconstructive surgery based on the biological principle of guided tissue regeneration (GTR). The aim of the present investigation was to evaluate the effect of using a polytetrafluorethylene (PTFE) membrane in GTR-treatment of recession-type defects and to examine the interrelationship between the PTFE membrane and surrounding periodontal tissues. Full-thickness flaps were raised around 24 maxillary premolar and molar teeth in 6 monkeys. The buccal alveolar bone was surgically removed to a level corresponding to the apical third of the roots. The exposed root surfaces were scaled and planed. In 12 teeth, PTFE membranes were adjusted to cover the exposed root surfaces from a level 1 to 2 mm apical to the CEJ, to a level 3 to 4 mm apical to the alveolar crest. The coronal border of the membranes was tightly adapted to the root surfaces by sling sutures. Twelve teeth served as control teeth without placement of membranes. The flaps were placed with the margin coronal to the CEJ and sutured. The animals were sacrificed after 3 months of healing and all experimental teeth were subjected to histological analysis. The membranes were found to be incorporated with the surrounding connective tissue, and the apical extension of the junctional epithelium terminated at the coronal border of the membranes. The amount of new attachment formation was on the average 74.3% of the defect height in the test teeth, which corresponded to 100% of the membrane covered root portion. Newly formed connective tissue attachment in the controls amounted to an average of 36.9% of the defect height.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Periodontology, University of Gothenburg, Sweden.
authors: J
authors: J
authors: Gottlow
authors: T
authors: T
authors: Karring
authors: S
authors: S
authors: Nyman
mesh_terms: D016301:Alveolar Bone Loss / Q000503:physiopathology; D000818:Animals; D001861:Bone Regeneration; D003094:Collagen; D003238:Connective Tissue / Q000502:physiology; D003739:Dental Cementum / Q000033:anatomy & histology / Q000502:physiology; D012534:Dental Scaling; D004846:Epithelial Attachment / Q000502:physiology; D005881:Gingiva / Q000033:anatomy & histology / Q000502:physiology; D005889:Gingival Recession / Q000503:physiopathology; D008252:Macaca fascicularis; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000601:surgery*; D010513:Periodontal Ligament / Q000033:anatomy & histology / Q000502:physiology*; D011138:Polytetrafluoroethylene; D012038:Regeneration; D013524:Surgical Flaps; D014092:Tooth Root / Q000601:surgery
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D003094:Collagen