Effects of fig latex on lipid peroxidation and CCl4-induced lipid peroxidation in rat liver.
The oral and intraperitoneal effects of fig milk latex on lipid peroxidation and CCl4-induced lipid peroxidation in liver homogenates of female rats were investigated. Oral treatment had no effect, while i.p. administration produced a significant increase in hepatic lipid peroxidation. When the latex was given before CCl4 treatment; it produced no protective effect against CCL4-induced hepatotoxicity. Addition of the latex to the incubation mixture produced a dose-dependent increase in lipid autoxidation, while the chloroform and ether extracts of the latex, as well as heated latex, had no effect on hepatic lipid autoxidation.
al-Bayati
Z A
ZA
Pharmacognosy and Pharmacology Department, Scientific Research Council, Jadiriyah, Baghdad, Iraq.
Alwan
A H
AH
D000284:Administration, Oral; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007840:Latex / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007840:Latex; D008315:Malondialdehyde; D002251:Carbon Tetrachloride