Effects of sympathetic stimulation on C-fibre response after peripheral nerve compression: an experimental study in the rabbit common peroneal nerve.
Non-myelinated C-fibre responses during sympathetic trunk stimulation were studied in rabbit common peroneal nerve 2 weeks after the nerve had been subjected to compression at 400 mmHg for 30 min. Our previous studies have demonstrated that during sympathetic trunk stimulation the compound action potential of uninjured somatic C-fibres is characterized by a reduced amplitude and an increased latency. In the present study, nerve compression changed the C-fibre response to sympathetic stimulation. Three out of eight nerves reacted to nerve compression by increased C-fibre compound action potential amplitude in response to sympathetic stimulation. In three other rabbits with compressed nerves the C-fibre action potential amplitude was unchanged, and in the remaining two rabbits the action potential amplitude was decreased during sympathetic stimulation. The action potential latency increased in all tested compressed C-fibres. The phenomenon of increased C-fibre amplitude during sympathetic activation has not been observed in uninjured nerves. As in uninjured nerves, noradrenaline infusion produced an increased C-fibre action potential amplitude and latency in six animals. Sympathetic stimulation did not affect the A-fibre response. These results indicate that sympathetic activity influences the conduction properties in C-fibres of somatic origin and that the response can be changed after a nerve injury. The findings may be of importance for the understanding of pain aggravation in different types of nerve injuries during increased sympathetic activity.
Shyu
B C
BC
Department of Physiology, University of Gothenburg, Sweden.
Danielsen
N
N
Andersson
S A
SA
Dahlin
L B
LB
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D008297:Male; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009412:Nerve Fibers / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010543:Peroneal Nerve / Q000502:physiology*; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000502:physiology*
D009638:Norepinephrine