title: Unilateral striatal grafts induce behavioral and electrophysiological asymmetry in rats with bilateral kainate lesions of the caudate nucleus.
abstract: Rats (n = 11) with bilateral kainate lesions of the caudate nucleus and subsequent unilateral transplantation of embryonic striatal tissue into the damaged area preferred 4 months later to reach for food with the forepaw contralateral to the graft. No such asymmetry was observed in lesioned, nontransplanted (n = 8) or unoperated (n = 5) control rats. Good integration of the graft with the host brain was indicated by the finding that cortical spreading depression did not enter the lesioned caudate nucleus but did penetrate into the lesioned caudate with the graft almost as regularly as in intact rats. Behavioral asymmetry produced by unilateral grafts in bilaterally lesioned animals reveals the effects of transplantation with more sensitivity than the graft-induced compensation of the asymmetries caused by unilateral lesions.
authors: Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
authors: V
authors: V
authors: Valousková
authors: V
authors: V
authors: Brácha
authors: J
authors: J
authors: Bures
authors: N
authors: N
authors: Hernandez-Mesa
authors: R
authors: R
authors: Macias-Gonzales
authors: Y
authors: Y
authors: Mazurová
authors: S
authors: S
authors: Nĕmecek
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D001931:Brain Mapping; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002421:Caudate Nucleus / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000196:embryology / Q000637:transplantation*; D013181:Cortical Spreading Depression / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology*; D004924:Escape Reaction / Q000502:physiology; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D007608:Kainic Acid; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology*; D009949:Orientation / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats
chemical_list: D007608:Kainic Acid