Context-specific morphine withdrawal in rats: duration and effects of clonidine.
Rats previously injected with morphine in a particular environment (paired rats) emitted more withdrawal symptoms in that environment than did rats previously injected with morphine in another environment (unpaired rats) after both 1 day and 5 days of morphine abstinence. Thus, reexposure to an environment previously associated with morphine can elicit context-specific withdrawal even after several days of morphine abstinence. Clonidine (0.06 mg/kg) reduced most of the withdrawal symptoms seen 5 days after morphine abstinence in both the paired and unpaired rats. However, clonidine enhanced many of the withdrawal symptoms in both groups of rats during naltrexone-precipitated withdrawal 1 day after morphine abstinence.
Kelsey
J E
JE
Department of Psychology, Bates College, Lewiston, Maine 04240.
Aranow
J S
JS
Matthews
R T
RT
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001245:Association Learning / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000523:psychology*; D009043:Motor Activity / Q000187:drug effects; D009271:Naltrexone / Q000494:pharmacology; D051381:Rats; D012931:Social Environment; D013375:Substance Withdrawal Syndrome / Q000523:psychology*; D015431:Weight Loss / Q000187:drug effects
D009271:Naltrexone; D009020:Morphine; D003000:Clonidine