Evaluation of 13C-urea breath test in the detection of Helicobacter pylori and in monitoring the effect of tripotassium dicitratobismuthate in non-ulcer dyspepsia.
Sixty nine patients with non-ulcer dyspepsia have been studied with endoscopy, biopsy, quick urease (CLO) test, Helicobacter pylori culture, and the 13C-urea breath test before and after treatment with tripotassium dicitratobismuthane (DeNol) two tablets twice daily for four weeks. Symptoms of non-ulcer dyspepsia were recorded using a standard questionnaire. Using H pylori culture as the gold standard, the sensitivity of the 13C-urea breath test was 90%, the specificity 98.6%, and the accuracy 94.8% with a positive predictive value of 98.2% and a negative predictive value of 92.5%. Conversion rate from H pylori positive to negative status after treatment with tripotassium dicitratobismuthate was 17.9%. Symptoms of non-ulcer dyspepsia improved appreciably after treatment irrespective of H pylori status. The 13C-urea breath test is an accurate research tool suitable for serial testing and population surveys.
Dill
S
S
Department of Gastroenterology, Central Middlesex Hospital, London.
Payne-James
J J
JJ
Misiewicz
J J
JJ
Grimble
G K
GK
McSwiggan
D
D
Pathak
K
K
Wood
A J
AJ
Scrimgeour
C M
CM
Rennie
M J
MJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D001431:Bacteriological Techniques; D001729:Bismuth / Q000627:therapeutic use; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes; D004415:Dyspepsia / Q000188:drug therapy* / Q000382:microbiology; D005069:Evaluation Studies as Topic; D005260:Female; D005773:Gastroscopy; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011706:Pyloric Antrum / Q000382:microbiology; D012680:Sensitivity and Specificity
D000863:Antacids; D002247:Carbon Isotopes; D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate; D001729:Bismuth