Microangiographic changes of the pancreatic ducts in experimental chronic pancreatitis.
Chronic pancreatitis was induced in eight piglets by dividing all pancreatic attachments to the duodenum. Five piglets served as controls. The animals which were operated on were autopsied six weeks thereafter. Ductography and microangiography were performed. Histological preparations of pancreatic tissue were made. All of the animals which underwent operation developed histologically verified chronic pancreatitis. Ductography revealed the main ducts and the side branches to be considerably dilated. They also exhibited variations in calibre and sudden obstructions. Two animals had a large non-infected pseudocyst. No communication between the cyst and the main duct could be demonstrated by ductography. No pancreatic calcifications were seen. The vasculature of the ductal plexuses seems to be derived from interlobular arteries. The animals with chronic pancreatitis had marked diminution of the vascular supply of the ducts. The changes in ductal vascularity correlated with the severity of the histological changes to the pancreas and may, thus, in part explain the progress of pancreatitis.
Pitkäranta
P
P
Department of Diagnostic Radiology, University Central Hospital, Helsinki, Finland.
D000792:Angiography; D000818:Animals; D002908:Chronic Disease; D005260:Female; D008297:Male; D008833:Microcirculation; D010179:Pancreas / Q000473:pathology; D010181:Pancreatic Cyst / Q000000981:diagnostic imaging / Q000473:pathology; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging* / Q000473:pathology; D010195:Pancreatitis / Q000000981:diagnostic imaging* / Q000473:pathology; D013552:Swine