Influence of parathyroidectomy on liver glycogen in rats treated with carbon tetrachloride.
Carbon tetrachloride (CCl4) brings about a rise in cytosolic free calcium which may lead to glycogen mobilization. Therefore, glycogen and glucose-6-phosphatase (G-6-pase) levels in the liver of parathyroidectomized (PTX) rats following CCl4 treatment have been estimated. CCl4 depletes both glycogen and G-6-pase levels in the liver. PTX followed by CCl4 administration, however, fails to restore liver glycogen and G-6-pase levels. The results suggest that neither cytosolic Ca2+ nor phospholipase A2 mediation is needed for glycogen mobilization, however, glucocorticoid intervention might have a role in such mechanisms.
Rastogi
S
S
Department of Zoology, Meerut University, India.
Rana
S V
SV
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000378:metabolism*; D005943:Gluconeogenesis; D006996:Hypocalcemia / Q000150:complications / Q000378:metabolism; D008112:Liver Glycogen / Q000032:analysis*; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D008112:Liver Glycogen