Basic relations among lesion laterality, lesion volume and neuropsychological performance.
Although it is widely accepted that lesion size is an important determinant of severity of deficit, difficulties in the quantification of lesion size and the absence of a theoretical model of how lesion volume combines with lesion locus to produce deficits have inhibited the development of methodological and statistical procedures for studying naturally occurring lesions in humans. We propose such a unified model and apply it to the analysis of neuropsychological performance in a sample of patients with naturally occurring unilateral lesions. The analysis suggests that a statistical interaction between lesion size and laterality may be an important determinant of neuropsychological deficit.
Turkheimer
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Department of Psychology, University of Virginia, Charlottesville 22903.
Yeo
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Bigler
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D000328:Adult; D001922:Brain Abscess / Q000503:physiopathology / Q000523:psychology; D001925:Brain Damage, Chronic / Q000503:physiopathology* / Q000523:psychology; D001930:Brain Injuries / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000503:physiopathology / Q000523:psychology; D002540:Cerebral Cortex / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed