title: Circadian profile of serum melatonin in Cushing's disease and acromegaly.
abstract: We evaluated the circadian profiles of serum melatonin (MT) and cortisol in 6 patients with Cushing's disease while those of serum MT and GH were evaluated in 8 patients with acromegaly. The control group consisted of 15 healthy subjects in whom MT, cortisol and GH were determined. The presence of a circadian rhythmicity was validated by the cosinor method, while the diurnal and nocturnal amount of MT secretion were expressed in terms of area under the curve. Gross alterations of MT rhythm were not apparent in Cushing's patients. In acromegalics, we observed a blunted day-night oscillation of MT accounted for by a significant increase of its secretion during the day-time period.
authors: Dipartimento di Scienze Cliniche e Biologiche, Università di Torini, Italy.
authors: A
authors: A
authors: Piovesan
authors: M
authors: M
authors: Terzolo
authors: G
authors: G
authors: Borretta
authors: M
authors: M
authors: Torta
authors: T
authors: T
authors: Buniva
authors: G
authors: G
authors: Osella
authors: P
authors: P
authors: Paccotti
authors: A
authors: A
authors: Angeli
mesh_terms: D000172:Acromegaly / Q000097:blood*; D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D003480:Cushing Syndrome / Q000097:blood*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged
chemical_list: D013006:Growth Hormone; D008550:Melatonin; D006854:Hydrocortisone