[Effects of phospholipase A2 on the etiology of pulmonary edema hemodynamics of lesser circulation in intact and vagotomized animals].
In experiments on white rats, guinea pigs and cats it was shown that intravenous infusion of phospholipase A2 (FLA2) caused the development of pulmonary edema (PE) in guinea pigs, but did not cause it in rats and cats. Bilateral vagotomy on the neck led to the appearance of the expressed edemogenous effect of FLA2 on the lungs. Pentobarbital anesthesia decreased the effect of vagotomy. This effect is not connected with the turn off of the efferent impulsation in vagus nerves as the infusion of atropine did not repeat the influence of vagotomy. Authors assume that the action of FLA2 is realized across the secretion of humoral factor in vagotomized animals and the increase of the permeability of the aero-hematic barrier.
Sanotskaia
N V
NV
Mikhaĭlov
V P
VP
Matsievskiĭ
D D
DD
D000818:Animals; D002415:Cats; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D010741:Phospholipases A / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D054467:Phospholipases A2; D011652:Pulmonary Circulation / Q000187:drug effects*; D011654:Pulmonary Edema / Q000139:chemically induced*; D051381:Rats; D014628:Vagotomy
D010741:Phospholipases A; D054467:Phospholipases A2
Vliianie fosfolipazy A2 na razvitie oteka legkikh i gemodinamiki malogo kruga u intaktnykh i vagotomirovannykh zhivotnykh.