Effects of tokishakuyakusan and keishibukuryogan on steroidogenesis by rat preovulatory follicles in vivo.
The effect of Tokishakuyakusan (TS) and Keishibukuryogan (KB) on estradiol-17 beta, progesterone and testosterone in serum and ovarian tissue from PMS-treated immature rats was examined in vivo. The in vivo intravenous administration of 20 micrograms of TS or KB increased the concentrations of estradiol-17 beta, progesterone and testosterone. These results suggest that TS and KB stimulate in vivo the production of estradiol-17 beta, progesterone and testosterone by preovulatory follicles, and that TS stimulation is more effective than KB.
Usuki
S
S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004958:Estradiol / Q000096:biosynthesis / Q000097:blood* / Q000737:chemistry; D005260:Female; D005498:Follicular Phase / Q000187:drug effects*; D010053:Ovary / Q000737:chemistry / Q000187:drug effects*; D011374:Progesterone / Q000096:biosynthesis / Q000097:blood* / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood* / Q000737:chemistry; D014018:Tissue Distribution
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C413220:toki-shakuyaku-san; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol