Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology.
Stimulation of astroglial 5-HT1A receptors causes astroglial cells to acquire a more mature morphology and to release a factor (or factors) which promotes growth of serotonergic neurons. By using an antibody-blocking approach, we have shown that at least one of the growth-promoting factors thus released is the astroglial-specific protein S-100. This may be a particularly important observation, in view of studies implicating S-100 in both Down's syndrome and Alzheimer's disease.
Whitaker-Azmitia
P M
PM
Department of Psychiatry, State University of New York, Stony Brook 11794.
Murphy
R
R
Azmitia
E C
EC
D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000648:ultrastructure; D002478:Cells, Cultured; D003470:Culture Media; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology*; D009418:S100 Proteins / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*
D003470:Culture Media; D006133:Growth Substances; D011985:Receptors, Serotonin; D009418:S100 Proteins; D012701:Serotonin