title: Trisomy 7 may be a primary change in noninvasive transitional cell carcinoma of the bladder.
abstract: We describe two cases of transitional cell carcinoma of the bladder associated with trisomy 7. In one of them, trisomy 7 was the only chromosome abnormality observed. In the second case, trisomy 7 was found in 25 (80.6%) of the metaphases; in two of them this was the only anomaly, while in three metaphases trisomy 8 was also present, and in other two trisomy 10 was also observed. Our results suggest that trisomy 7 could be a primary change in TCC, and a review of the literature indicates that when it is present as the sole karyotypic abnormality is may be associated with a non-invasive behavior of the tumor.
authors: Institut de Biologia Fonamental Vincent Villar Palasí, Universitat Autònoma de Barcelona, Spain.
authors: G
authors: G
authors: Berrozpe
authors: R
authors: R
authors: Miró
authors: M R
authors: MR
authors: Caballin
authors: J
authors: J
authors: Salvador
authors: J
authors: J
authors: Egozcue
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D014314:Trisomy; D001749:Urinary Bladder Neoplasms / Q000235:genetics*