[ Anticataleptic effect of delta sleep-inducing peptide and its action on brain monoamine oxidase in rats genetically predisposed to catalepsy].
Rats with genetic susceptibility to catalepsy (GC strain) were compared with Wistar rats (W). After an intraperitoneal administration of 120 micrograms/100 g delta sleep-inducing peptide (DSIP) in GC rats the duration of cataleptic freezing was shortened (13.8 +/- 9.5 sec against 27.2 +/- 7.5 sec in control). MAO-B activity decreased due to DSIP administration both in GC and W rats. It is hypothesized that the DSIP effect MAO-B in GC rats may correct the lost MAO-A function in deamination of dopamine, a common MAO-A and MAO-B substrate, and the dopaminergic neurotransmission in catalepsy.
Voĭtenko
N N
NN
Kolpakov
V G
VG
Alekhina
T A
TA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002375:Catalepsy / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase
Antikataleptogennyĭ éffekt peptida del'ta-sna i ego vliianie na monoaminoksidazy mozga geneticheski predraspolozhennykh k katalepsii krys.