Dose response of alcuronium and d-tubocurarine in infants, children and adolescents.
Seventy neonatal to adolescent general surgical patients were studied to create an individual dose-response curve for the long-acting neuromuscular blocking agents, alcuronium and d-tubocurarine. The mean (SEM) ED95 of alcuronium was 196 (9), 271 (13) and 243 (8) micrograms/kg in infants, children and adolescents, respectively (P less than 0.01). d-tubocurarine showed a similar age dependent dose-response relationship. ED95 doses were 414 (40), 499 (41) and 445 (31) micrograms/kg, respectively. The onset time (time from intravenous administration to maximal effect) following equipotent dosages was 40-50% shorter in infants than in children or adolescents (1.5 vs 2.7 minutes, P less than 0.05).
Meretoja
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Department of Anaesthesia, Royal Children's Hospital, Melbourne.
Brown
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Clare
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D000293:Adolescent; D000375:Aging / Q000502:physiology*; D000443:Alcuronium / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D006801:Humans; D007223:Infant; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D012044:Regression Analysis; D014403:Tubocurarine / Q000008:administration & dosage* / Q000494:pharmacology
D000443:Alcuronium; D014403:Tubocurarine