title: Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals.
abstract: We determined plasma methocarbamol concentrations over 24 h following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic haemodialysis patients and compared these results to those from 17 healthy male volunteers. The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 h, respectively. tmax and the weight-adjusted Cmax were 1.1 h and 27.0 mg.m-1 for haemodialysis patients and 1.1 and 23.1 mg.l-1 for normals. Relative systemic availability was assessed by comparing weight-normalized AUC x k10 products. These results indicate no significant differences with respect to methocarbamol absorption, with the relative systemic availability in patients being 113%. These data suggest that absorption and elimination of methocarbamol is similar between normal subjects and patients undergoing maintenance haemodialysis.
authors: Division of Nephrology, Medical College of Virginia, Richmond.
authors: D A
authors: DA
authors: Sica
authors: T J
authors: TJ
authors: Comstock
authors: J
authors: J
authors: Davis
authors: L
authors: L
authors: Manning
authors: R
authors: R
authors: Powell
authors: A
authors: A
authors: Melikian
authors: G
authors: G
authors: Wright
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008721:Methocarbamol / Q000493:pharmacokinetics*; D011485:Protein Binding; D006435:Renal Dialysis
chemical_list: D008721:Methocarbamol