Effects of prolonged administration of anti-cumulus oophorus antibody on reproduction in mice.
Mice were passively immunized over 6 weeks with contraceptive doses of an anti-cumulus oophorus antibody preparation. The persistence of oestrus, accompanied by complete inhibition of conception, was observed throughout treatment. After cessation of treatment, fertility was restored within 2 weeks. Histological examination did not reveal any depletion of the ovarian oocyte stock. These results warrant further research into the nature of cumulus antigens and their use in active immunization studies.
Tesarik
J
J
INSERM Unité 187, Hôpital Antoine-Béclère, Clamart, France.
Testart
J
J
Nomé
F
F
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D003269:Contraception, Immunologic / Q000379:methods*; D004971:Estrus; D005260:Female; D005306:Fertilization; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D009865:Oocytes / Q000276:immunology*; D010053:Ovary / Q000033:anatomy & histology; D012098:Reproduction / Q000502:physiology*; D013997:Time Factors
D000906:Antibodies