Effect of perinatal lead exposure on morphine tolerance in the neonatal rat.
Administration of lead (at 300 and 1000 ppm) in the maternal drinking water from conception to postnatal day 10 increased the sensitivity of 10-day rat pups to noxious stimuli and disrupted the dose-response relationship to morphine antinociception. Lead-exposed rats could be made tolerant to morphine over a 5-day period (twice daily injections of 5 mg/kg morphine, postnatal days 5-10) and antinociceptive responses in tolerant rats were also disrupted by lead exposure.
Kitchen
I
I
Department of Biochemistry, University of Surrey, Guildford, U.K.
Boswell
J A
JA
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008431:Maternal-Fetal Exchange; D009021:Morphine Dependence / Q000209:etiology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D007854:Lead