Antibodies to fibronectin bind to plaques and other structures in Alzheimer's disease and control brain.
Antibodies to fibronectin (Fn) bind not only the basal lamina in Alzheimer's disease brain, but also crystal-like formations in the grey matter, senile plaques, a subset of neuronal perikarya, and large highly processed stellate formations which were both neurofilament and glial fibrillary acidic protein (GFAP) negative and which were identified at a lower frequency in non-demented control brains.
Howard
J
J
Department of Neuropathology, Institute of Psychiatry, London, U.K.
Pilkington
G J
GJ
D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001921:Brain / Q000276:immunology* / Q000473:pathology; D003094:Collagen / Q000276:immunology; D005353:Fibronectins / Q000276:immunology*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000276:immunology; D013233:Stellate Ganglion / Q000473:pathology
D000906:Antibodies; D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein; D007797:Laminin; D003094:Collagen