Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes.
The effect of oral administration of endosulfan (12.5 mg/kg body weight), daily for 4 days was investigated on erythrocytes of female rats of 4 different age groups i.e. 15, 30, 70 and 365 days old. Erythrocyte membrane Na+, K(+)-ATPase and Mg2(+)-ATPase activities were significantly inhibited in all the age groups of rats. However, percent inhibition was maximum in the youngest animals. A significant decrease in the activity of erythrocyte glutathione reductase was observed in 30 and 70 days old rats whereas a significant increase in the activity of glucose-6-phosphate dehydrogenase (G-6-PD) was observed in these groups. The increase in G-6-PD activity may be a physiological response to compensate for decrease in the reduced glutathione level which results from decrease in the activity of glutathione reductase.
Kiran
R
R
Department of Biochemistry, Panjab University, Chandigarh, India.
Varma
M N
MN
D000367:Age Factors; D000375:Aging / Q000097:blood*; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004351:Drug Resistance; D004726:Endosulfan / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005978:Glutathione / Q000097:blood; D051381:Rats
D005978:Glutathione; D004726:Endosulfan