[Functional-metabolic activity of the mononuclear phagocyte system of the blood, liver, spleen and skin in children with hepatitis B].
A total of 102 children aged 5 to 14 years with virus hepatitis B were examined for the status of the mononuclear phagocytic system in accordance with the absolute monocyte count in the circulating blood, esterase and acid phosphatase activity in the monocytes, for function of organ macrophages of the liver and spleen using dynamic scintigraphy with TC-colloid and for macrophages of the skin by the "skin window" method. The rise of the absolute count and lowering of the functional and metabolic activity of blood monocytes were directly proportional to the gravity of virus hepatitis B. The changes persisted for a long time, namely up to 1.5 to 3 months since the disease onset. There was a progressive drop of the functional activity of Kupffer cells in the liver with a maximum decrease seen within 4 to 6 weeks since the disease onset, followed by returning to normal in cyclic disease and preservation of the changes in lingering and chronic virus hepatitis B. Spleen macrophages play an active compensatory role, maintaining normal "purifying" function of the mononuclear phagocytic system. That compensatory response tension appeared high in lingering and especially in chronic virus hepatitis and may serve as a criterion for process chronicity. The changes in the mononuclear phagocytic system observed in cyclic course of mild and medium-gravity virus hepatitis B may be regarded as normal adaptive reaction and do not require any drug correction. The latter one may only be indicated in patients with grave, lingering or chronic disease patterns associated with break down or depletion of the adaptive mechanisms of the system in question.
Reĭzis
A R
AR
Nikitina
T S
TS
Shalygina
N B
NB
Serebrovskaia
L V
LV
Mironov
S N
SN
D000135:Acid Phosphatase / Q000378:metabolism; D000293:Adolescent; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004950:Esterases / Q000378:metabolism; D006509:Hepatitis B / Q000097:blood / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D009000:Monocytes / Q000201:enzymology / Q000276:immunology*; D012867:Skin / Q000473:pathology*; D013154:Spleen / Q000473:pathology*
D004950:Esterases; D000135:Acid Phosphatase
Funktsional'no-metabolicheskaia aktivnost' sistemy mononuklearnykh fagotsitov krovi, pecheni i selezenki, dermy pri virusnom gepatite B u dete'i.