Occurrence of cerebrohepatorenal (Zellweger) syndrome in the Karaite community in Israel: a genetic hypothesis.
Two infants with the cerebrohepatorenal (Zellweger) syndrome in Karaite families are described. This syndrome has an autosomal recessive mode of inheritance with an estimated incidence of between 1:25,000 and 1:100,000 live births. In addition to a previous report of the syndrome in a Karaite family, this report raises the possibility of a high incidence of Zellweger Syndrome among the Karaites in Israel.
Zung
A
A
Department of Pediatrics A, Kaplan Hospital, Rehovot, Israel.
Mogilner
B M
BM
Nissani
R
R
Appelman
Z
Z
Gelman de Kohan
Z
Z
D000328:Adult; D003466:Cultural Characteristics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007231:Infant, Newborn; D007557:Israel; D007599:Judaism; D008297:Male; D010375:Pedigree; D015211:Zellweger Syndrome / Q000208:ethnology / Q000235:genetics*