title: The effects of single dose oral hydralazine on blood flow through human lung tumours.
abstract: Hydralazine has been shown to reduce tumour blood flow and to potentiate the cytotoxicity of melphalan and bioreductive agents in mice. In order to determine whether such a strategy might have clinical potential, a study was undertaken to investigate the effects of hydralazine on blood flow through human tumours. Twenty-two patients with carcinoma of the bronchus received a single oral dose of hydralazine in the range 25 to 150 mg (0.37-2.86 mg/kg) according to age and acetylator status. Tumour blood flow was assessed by single photon emission computed tomography (SPECT) performed 10 min following intravenous 99Tcm-HMPAO on two occasions 2-8 days apart, the second being performed 60 min after hydralazine administration. In 20 evaluable patients, hydralazine caused a 38% increase in blood flow through the whole tumour (p = 0.007) and a 28% increase in flow through the tumour centre (p = 0.03) with greater increases occurring in patients sustaining greater falls in peripheral resistance. Tumour vascular resistance fell indicating active vasodilation in arterioles supplying tumours. Side-effects due to hydralazine were reported by eight patients.
authors: Department of Radiotherapy, Royal Marsden Hospital, Sutton, Surrey, U.K.
authors: N P
authors: NP
authors: Rowell
authors: M A
authors: MA
authors: Flower
authors: V R
authors: VR
authors: McCready
authors: B
authors: B
authors: Cronin
authors: A
authors: A
authors: Horwich
mesh_terms: D000284:Administration, Oral; D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000098:blood supply* / Q000000981:diagnostic imaging; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D014664:Vasodilation / Q000187:drug effects
chemical_list: D006830:Hydralazine