title: Excretion of urinary protein induced by extracorporeal piezoelectric lithotripsy.
abstract: An investigation was carried out into renal injury caused by extracorporeal piezoelectric lithotripsy (EPL) using an EDAP lithotriptor. Four urinary proteins, with a molecular weight range of 160000-14500, immunoglobulin G (IgG), N-acetyl-beta-glucosaminidase (NAG), albumin and lysozyme, were monitored in 27 patients 1 day before and 1, 7, 30, 90 and 180 days after unilateral EPL treatment. All patients had non-obstructive renal stones, previously untreated. Apart from 5 patients with stablised hypertension and 6 with persistent urinary infections due to the infected stones, all patients appeared healthy, as confirmed by clinical, haematological and biochemical investigations. Only albumin levels increased significantly 1 day after treatment; statistically nonsignificant increases and decreases were recorded in the levels of NAG and lysozome respectively. IgG was beyond the limit of detection (less than 0.5 mg%) in all patients. The albumin level returned to normal 7 days after treatment. The EPL-induced increase in albumin was recorded in 88% of patients, compared with increased levels of NAG in 46% and lysozyme in 64%, mainly in those with infected stones. These findings indicated a transient glomerular injury after EPL treatment.
authors: Department of Biochemistry, Carmel Hospital, Haifa, Israel.
authors: M
authors: M
authors: Barak
authors: Y
authors: Y
authors: Ginesin
authors: L
authors: L
authors: Hornstein
authors: D R
authors: DR
authors: Levin
authors: N
authors: N
authors: Gruener
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000209:etiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007668:Kidney / Q000293:injuries* / Q000503:physiopathology; D007669:Kidney Calculi / Q000503:physiopathology / Q000628:therapy; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000652:urine; D011507:Proteinuria / Q000209:etiology*; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D009113:Muramidase; D000118:Acetylglucosaminidase