title: The influence of repeated oral administration of dichlorvos on circulating esterases in buffalo calves (Bubalus bubalis).
abstract: Alterations in circulating esterases induced by dichlorvos and their reversibility were investigated in male buffalo calves. Changes in blood glucose and total plasma proteins were also monitored. Animals received 4 or 8 mg dichlorvos/kg/day po for 28 consecutive d. Dichlorvos caused dose- and time- dependent significant (P less than 0.01) inactivation of blood esterases. Maximal inhibition of plasma cholinesterase (87-94%) and serum carboxylesterase (51-67%) was observed on the 28th day. An increase in blood glucose and total plasma proteins occurred during the dosing period; these parameters returned to control values in surviving animals within 7 d after the final dose. Activities of esterases returned to 45-70% of normal the 14th d after cessation of dichlorvos dosing.
authors: Department of Pharmacology, Punjab Agricultural University, Ludhiana, India.
authors: R
authors: R
authors: Raina
authors: A K
authors: AK
authors: Srivastava
authors: J K
authors: JK
authors: Malik
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001798:Blood Proteins / Q000187:drug effects; D002020:Buffaloes / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D004006:Dichlorvos / Q000008:administration & dosage* / Q000097:blood; D004334:Drug Administration Schedule; D008297:Male
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004006:Dichlorvos; D002802:Cholinesterases