Effect of thymic hormones on induction of experimental allergic encephalomyelitis in old mice.
This study was aimed at restoring decreased T-cell functions and reduced susceptibility to proteolipid apoprotein (PLP) induced-experimental allergic encephalomyelitis (EAE) in old mice with thymic hormones. Thymosin fraction 5 (TF-5) and serum thymic factor (FTS) had no significant in vitro and in vivo effect on proliferative responses to PLP and concanavalin A (Con A), and on EAE induction in young and old mice. These results suggest that decreased T-cell functions cannot be restored by these thymic hormones tested.
Endoh
M
M
Division of Demyelinating Disease and Aging, National Center of Neurology and Psychiatry, Tokyo.
Tabira
T
T
D000375:Aging / Q000276:immunology; D000818:Animals; D001059:Apoproteins / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D005260:Female; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009185:Myelin Proteins / Q000276:immunology; D018991:Myelin Proteolipid Protein; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013935:Thymic Factor, Circulating / Q000494:pharmacology; D013947:Thymosin / Q000031:analogs & derivatives / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology*
D001059:Apoproteins; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D013951:Thymus Hormones; C033782:thymosin fraction 5; D013947:Thymosin; D013935:Thymic Factor, Circulating