Memory deficits following nucleus basalis magnocellularis lesions may be mediated through limbic, but not neocortical, targets.
In order to test the contribution of the target areas of the nucleus basalis magnocellularis to the mediation of item and order recognition memory for spatial locations, one set of rats received lesions of the dorsolateral frontal cortex, parietal cortex, or basolateral amygdala after training in an order recognition memory task, whereas another set of animals received lesions of the nucleus basalis magnocellularis or basolateral amygdala in an item recognition memory task. Animals with basolateral amygdala lesions displayed a deficit for order recognition memory, but no deficit for item recognition memory, a pattern equivalent to that found for animals with nucleus basalis magnocellularis lesions. In contrast, animals with dorsolateral frontal cortex displayed no deficit, and animals with parietal cortex lesions displayed only a partial deficit for order recognition memory, results that differ from those found for animals with nucleus basalis magnocellularis lesions. It appears that the nucleus basalis magnocellularis influences item and order recognition memory for lists of spatial locations primarily through projections to limbic but not neocortical targets.
Kesner
R P
RP
Department of Psychology, University of Utah, Salt Lake City 84112.
Crutcher
K A
KA
Omana
H
H
D000679:Amygdala / Q000473:pathology / Q000502:physiology; D000818:Animals; D001479:Basal Ganglia / Q000473:pathology / Q000502:physiology*; D005625:Frontal Lobe / Q000473:pathology / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013028:Space Perception / Q000502:physiology