Prediction of water vapor transport rates across polyvinylchloride packaging systems using a novel radiotracer method.
A radiotracer method is used to study the transport properties of water vapor in polyvinylchloride (PVC), a plastic commonly used in the packaging of parenteral solutions. Water vapor transport across a PVC film appears to be Fickian in nature. Using the steady-state solution of Fick's second law and the permeability coefficient of water vapor across the PVC film obtained using the described method, the predicted water vapor transport rate (WVTR) for a parenteral solution packaged in PVC is in reasonable agreement with actual WVTR as determined by weight loss under precisely controlled conditions.
Wood
R W
RW
Pharmaceutical R & D, Baxter Healthcare Corporation, Round Lake, Illinois.
Mulski
M J
MJ
Kuu
W Y
WY
D003903:Deuterium / Q000032:analysis*; D004058:Diffusion; D004349:Drug Packaging / Q000379:methods*; D004356:Drug Storage; D011143:Polyvinyl Chloride; D014867:Water / Q000032:analysis*
D014867:Water; D011143:Polyvinyl Chloride; D003903:Deuterium