A further study on the membrane currents related to Ba-induced pacemaker in the bullfrog atrium.
In the SR-poor frog atrial muscle, the presence of transient inward current (ITI) was demonstrated in Ba (0.2-0.3 mM) Ringer after treatment with isoproterenol. A peculiar slow inward current (IU) superposing on the tail of the delayed outward current (IX) was also elucidated at the maximum diastolic potential level, which may enhance the pacemaker depolarization.
Goto
M
M
Division of Food and Nutrition, Nakamura Gakuen College, Fukuoka, Japan.
Tsujisaki
E
E
D000818:Animals; D016275:Atrial Function; D001464:Barium / Q000494:pharmacology*; D001683:Biological Clocks / Q000187:drug effects* / Q000502:physiology; D004553:Electric Conductivity / Q000187:drug effects* / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008564:Membrane Potentials / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D011892:Rana catesbeiana / Q000502:physiology*
D001464:Barium; D007545:Isoproterenol