Insulin immunoreactivity in the fetal and neonatal rat retina.
The ganglion cell layer of pre- and postnatal rat retina is positive for insulin immunoreactivity. At birth the inner nuclear layer also stains for insulin. By 5 days after birth the layers characteristic of the mature retina are demonstrable. At this time the outer nuclear layer and both limiting membranes show insulin reactivity. The lens is positive for insulin at all stages studied and the retinal pigment and choroid layers are positive after birth. These observations suggest that insulin may be important in differentiation and/or maturation of the retina.
Meimaridis
D G
DG
Department of Anatomy, Medical College of Ohio, Toledo 43699.
Morse
D E
DE
Pansky
B
B
Budd
G C
GC
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007150:Immunohistochemistry; D007328:Insulin / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000254:growth & development / Q000378:metabolism*
D007328:Insulin