[Gonadal function after cancer treatments in childhood].
Treatments given for childhood malignancies can alter gonadal function by several mechanisms: (1) cranial irradiation may cause either gonadotrophin deficiency or premature puberty. (2) Irradiation of the testes can induce germinal epithelium dysfunction even if the dose delivered is very low; Leydig cell failure occurs beyond 5-6 Gy and ovarian insufficiency beyond 6-7 Gy. (3) Chemotherapy is considerably more toxic for the germinal epithelium of the testes than for the ovaries; alkylating agents are especially toxic. Analysis of the consequences of preparation for bone marrow transplantation by chemotherapy or total body irradiation will be required when longer follow-up are available.
Brauner
R
R
Unité d'Endocrinologie et Diabétologie de l'enfant, Hôpital des Enfants Malades, Paris.
Thibaud
E
E
Rappaport
R
R
D000970:Antineoplastic Agents / Q000009:adverse effects*; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006066:Gonads; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010049:Ovarian Diseases / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D013733:Testicular Diseases / Q000209:etiology
D000970:Antineoplastic Agents
Fonction gonadique après traitement des cancers de l'enfant.