title: Influence of phosphatidylcholine on ultrafiltration and solute transfer in CAPD patients.
abstract: Fifteen patients (mean age 59.9 +/- 16.1 years) treated by CAPD for a mean of 21.6 +/- 14 months, underwent peritoneal clearances before and after 15 days of intraperitoneal phosphatidylcholine (PC) treatment (50 mg/L). No difference was observed in urea, creatinine, uric acid, and reverse dextrose clearances. A statistically significant increase in phosphate clearances (4 and 6 hr dwell times) (1.36%) and a reduction in drainage volume (2 hr dwell time) (1.36%) were observed after treatment. Urine output and percent dextrose reabsorption were unchanged. The ultrafiltration (UF) showed a tendency to increase, which lasted for 15 days after discontinuation of treatment. This tendency allowed the patients to reduce, during the same period, the amount of hypertonic solution (23.8 L vs. 21.3 L) required. The tendency to increase UF over time deserves further study.
authors: Division of Nephrology, Regional Hospital, Foggia, Italy.
authors: M
authors: M
authors: Querques
authors: D A
authors: DA
authors: Procaccini
authors: A
authors: A
authors: Pappani
authors: P
authors: P
authors: Strippoli
authors: A
authors: A
authors: Passione
mesh_terms: D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D003131:Combined Modality Therapy; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010710:Phosphates / Q000097:blood; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D014527:Uric Acid / Q000097:blood
chemical_list: D010710:Phosphates; D010713:Phosphatidylcholines; D014527:Uric Acid; D003404:Creatinine