Fractionated total body irradiation for bone marrow transplantation: clinical results on 66 patients.
Short term clinical results of bone marrow transplantation on 66 patients conditioned with fractionated total body irradiation (12 Gy in 6 fractions and 3 days) are presented here. An acute toxic effects incident, similar to that obtained previously, a 27.6% interstitial pneumonitis associated with acute severe graft versus host disease in 77% of cases, 19.2% relapses, and 41% total crude survival with an actuarial probability of surviving for more than two years of 46% for ALL, 64% for AML and 28% for CML, are the results obtained since now.
Valls
A
A
Servicio de Radioterapia, Hospital de la Esperanza, Barcelona, Spain.
Ferrer
E
E
Algara
M
M
Rubio
A
A
Grañena
A
A
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology*; D006801:Humans; D007938:Leukemia / Q000532:radiotherapy* / Q000601:surgery; D008223:Lymphoma / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000453:epidemiology*; D011836:Radiation Tolerance; D012189:Retrospective Studies; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000379:methods