Lack of effect of pinacidil on theophylline pharmacokinetics and metabolism in man.
Pinacidil, a pyridyl cyanoguanidine derivative, is a new antihypertensive vasodilator drug. It shares structural similarities with the histamine H2-receptor blocker cimetidine, an imidazole cyanoguanidine derivative, which is a potent inhibitor of cytochrome P-450 and of theophylline metabolism. In the present study the pharmacokinetics and metabolism of theophylline were determined in six healthy volunteers before and on the last day of oral pinacidil administration for two weeks. The dosage of pinacidil was 12.5 mg twice a day in the first week and 25 mg in the second. There were no significant changes in theophylline plasma clearance, terminal half-life or volume of distribution during pinacidil administration. Also the renal and metabolic clearance of theophylline and the formation clearances of the major theophylline metabolites in the urine (DMU, 1MU, 3MX) did not change significantly during administration of therapeutic doses of pinacidil.
Nielsen-Kudsk
J E
JE
Department of Internal Medicine, Silkeborg General Hospital, Denmark.
Nielsen
C B
CB
Mellemkjaer
S
S
Siggaard
C
C
D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D020110:Pinacidil; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D006146:Guanidines; D014665:Vasodilator Agents; D020110:Pinacidil; D013806:Theophylline