title: Coronary artery disease in Chinese males without hypercholesterolaemia.
abstract: The aim of this study was to determine the frequency of various metabolic risk factors for coronary artery disease (CAD) in 246 male patients studied over a 2-year period. CAD was diagnosed on the basis of a history indicative of angina pectoris, an electrocardiogram diagnostic of myocardial ischaemia, and a positive coronary angiogram. Thirty-eight per cent of this population had diabetes, hypertension or both. Of the remaining individuals, 39% had a plasma cholesterol concentration greater than 5.2 mmol l-1, whereas 23% had a cholesterol concentration less than 5.2 mmol l-1. Plasma lipid and lipoprotein levels of a non-smoking subset of those subjects with a total cholesterol concentration less than 5.2 mmol l-1 were compared with values of a matched group of individuals who did not have significant vessel disease as revealed by angiography. The results of these investigations indicated that patients with CAD and a plasma cholesterol concentration less than 5.2 mmol l-1 exhibited an increase in plasma triglyceride concentration and a decrease in plasma HDL-cholesterol concentration. Since these subjects were not diabetic, hypertensive or hypercholesterolaemic, it is suggested that the observed changes in triglyceride and HDL metabolism made a major contribution to the CAD in these individuals.
authors: Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan.
authors: S M
authors: SM
authors: Shieh
authors: M M
authors: MM
authors: Fuh
authors: D C
authors: DC
authors: Shen
authors: Y D
authors: YD
authors: Chen
authors: G M
authors: GM
authors: Reaven
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology* / Q000209:etiology; D048909:Diabetes Complications; D004562:Electrocardiography; D006801:Humans; D006937:Hypercholesterolemia; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013624:Taiwan / Q000453:epidemiology
chemical_list: D002784:Cholesterol