Disseminated mycobacterial infection in a hemophilia B patient with acquired immunodeficiency syndrome.
Disseminated mycobacterial infection was found at autopsy in a male patient with hemophilia B and acquired immunodeficiency syndrome (AIDS). In May 1986, 23 months before death, the patient had encephalitis for one month and in July he developed a fever, malaise and generalized lymphoadenopathy. Human immunosuppressive virus (HIV) was positive and the CD 4/8 ratio of lymphocyte surface markers was 0.1, but mycobacterium was not detected. In September 1986, he had severe dyspnea due to interstitial pneumonia and he was treated with high-dose methylprednisolone. He died after a 23-month course of fever, severe weight loss and terminal progressive deterioration, although he was treated with antibiotics, antifungal agents, gamma-globulin, steroid and a Azidothymidine.
Wada
H
H
Second Department of Internal Medicine, Faculty of Medicine, Mie University, Tsu, Japan.
Ohiwa
M
M
Mori
Y
Y
Tanigawa
M
M
Tamaki
S
S
Kobayashi
T
T
Minami
N
N
Deguchi
K
K
Shirakawa
S
S
Kusano
I
I
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D001772:Blood Cell Count; D015153:Blotting, Western; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D008297:Male; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000473:pathology; D011859:Radiography; D013154:Spleen / Q000473:pathology