title: The adsorption of quinine and quinidine to activated charcoal with and without magnesium sulfate.
abstract: The effect of magnesium sulfate on the in vitro adsorption of quinine and quinidine to activated charcoal (AC) was studied. Solutions of quinine and quinidine were prepared at concentrations of 5 and 10 micrograms/ml and at simulated toxic concentrations of 62.5, 125 and 250 micrograms/ml in distilled water. Drug-charcoal slurries were vortex mixed, centrifuged and analysed for free drug in the supernatant. Quinine had adsorption capacities of 78.2 to 100% with 12.5 or 50 mg AC; 12.5 or 50 mg AC adsorbed 29.5-87.2% of the quinidine. Quinine (250 micrograms/ml) had adsorption capacities of 0.0, 21.1, 52.4, 78.3 or 93.8% to 12.5, 50, 125, 250 or 500 mg AC, respectively. There was a corresponding increase quinine and quinidine adsorption at increasing concentrations of AC. The adsorption of quinine and quinidine seemed dose dependent. Magnesium sulfate (7.5 mg/ml) enhanced the adsorption of quinine to AC, but increased the amount of AC required for quinidine-charcoal adsorption.
authors: Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
authors: A
authors: A
authors: Akintonwa
authors: O E
authors: OE
authors: Orisakwe
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000931:Antidotes / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use*; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology*; D011041:Poisoning / Q000628:therapy; D011802:Quinidine / Q000493:pharmacokinetics / Q000506:poisoning*; D011803:Quinine / Q000493:pharmacokinetics / Q000506:poisoning*
chemical_list: D000931:Antidotes; D002606:Charcoal; D008278:Magnesium Sulfate; D011803:Quinine; D011802:Quinidine