Short term anti-tubercular drug therapy and hepatic microsomal enzyme activity. Antipyrine metabolism as an index.
The effect of short course chemotherapy on the drug metabolising capacity of the liver was studied in 7 newly diagnosed pulmonary tuberculosis patients, using antipyrine as a model drug. Antipyrine elimination half-life and plasma clearance rate were not significantly altered by 3 weeks of therapy. It is concluded that short course chemotherapy does not affect antipyrine metabolising enzyme activity.
Hamide
A
A
Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
Sivagnanam
G
G
Raveendran
R
R
Adithan
C
C
Sivaraman
V
V
Chandrasekar
S
S
D000328:Adult; D000983:Antipyrine / Q000032:analysis* / Q000378:metabolism; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D012463:Saliva / Q000737:chemistry; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism
D000995:Antitubercular Agents; D000983:Antipyrine