title: The effect of arsenic trioxide on brain monoamine metabolism and locomotor activity of mice.
abstract: The arsenic trioxide (AsT) content, and monoamine levels in the cerebral cortex, hippocampus, hypothalamus and corpus striatum were determined in mice administered AsT (3 and 10 mg/kg) for 14 days. The vertical and horizontal motor activity was also examined. The AsT content in discrete brain areas differed but was clearly dose-dependent. Metabolites of norepinephrine and dopamine increased in the cerebral cortex, hippocampus and hypothalamus and decreased in the corpus striatum in AsT-treated mice. Metabolites of 5-hydroxytryptamine increased in all the discrete brain areas. The vertical and horizontal motor activity was increased by AsT at 3 mg/kg and decreased by AsT at 10 mg/kg. These results show that AsT modifies CNS metabolism and function at low doses. AsT penetrates the blood-brain barrier to cause these effects.
authors: Department of Pharmacology, School of Dentistry, Iwate Medical University, Morioka, Japan.
authors: T
authors: T
authors: Itoh
authors: Y F
authors: YF
authors: Zhang
authors: S
authors: S
authors: Murai
authors: H
authors: H
authors: Saito
authors: H
authors: H
authors: Nagahama
authors: H
authors: H
authors: Miyate
authors: Y
authors: Y
authors: Saito
authors: E
authors: E
authors: Abe
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010087:Oxides
chemical_list: D001152:Arsenicals; D010087:Oxides; D001151:Arsenic; D000077237:Arsenic Trioxide