title: Cardiac asthma presenting as status asthmaticus: deleterious effect of epinephrine therapy.
abstract: Epinephrine is a potent bronchodilator currently used to treat severe asthma, although there is no proven advantage of this drug over beta 2 adrenergic agonists. By contrast, as demonstrated here, the use of such a potent vasoconstrictor can worsen hemodynamic status when left ventricular dysfunction is associated with asthma or is the cause for dyspnea. We describe the case of a 60-year-old man with an history of chronic asthmatic bronchitis admitted for status asthmaticus. Bronchodilator therapy, including high dosages of intravenous epinephrine, failed to improve the patient and he was intubated and mechanically ventilated. Several hours later, a right heart catheterization revealed severe unexpected left heart dysfunction with a capillary wedge pressure of 45 mmHg and a cardiac index of 1.7 l/min/m2. Epinephrine was gradually stopped which resulted in a decrease in mean arterial blood pressure and an improvement of hemodynamic status. He was discharged on home mechanical ventilation. In this patient, ischemic left heart failure was revealed by a clinical picture mimicking status asthmaticus. Epinephrine, given as bronchodilator therapy on an empiric basis precipitated the patient into cardiogenic shock. Therefore this drug should not be recommended in face of the possibility of cardiac asthma or associated cardiac dysfunction.
authors: Medical Intensive Care Unit, Paris XII Université, Hôpital Henri-Mondor, Créteil, France.
authors: D
authors: D
authors: Fletcher
authors: J L
authors: JL
authors: Mainardi
authors: C
authors: C
authors: Brun-Buisson
authors: F
authors: F
authors: Lemaire
authors: L
authors: L
authors: Brochard
mesh_terms: D003937:Diagnosis, Differential; D004418:Dyspnea, Paroxysmal / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013224:Status Asthmaticus / Q000175:diagnosis* / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D004837:Epinephrine