Proinsulin autoantibodies: association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type.
Antibodies reacting with proinsulin but not with insulin determinants have been observed recently in Type I diabetes. We describe here that ELISA-determined proinsulin autoantibodies (IgG-PAA) also occur in first-degree relatives of IDDM patients (38/513, 7.4% vs 1.9% in controls, P less than 0.025). In contrast to insulin autoantibodies (IgG-IAA) and islet cell antibodies (ICA) no association with HLA type was found. Furthermore, IgG-PAA occur independently of IgG-IAA and ICA. We conclude that the humoral autoimmune response to proinsulin determinants is under separate genetic control.
Kuglin
B
B
Diabetes Research Institute, University of Düsseldorf, FRG.
Halder
B
B
Bertrams
J
J
Grüneklee
D
D
Gries
F A
FA
Kolb
H
H
D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007328:Insulin / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D010375:Pedigree; D015995:Prevalence; D011384:Proinsulin / Q000276:immunology*
D001323:Autoantibodies; D006684:HLA-DR Antigens; D007070:Immunoglobulin A; D007328:Insulin; D011384:Proinsulin