title: [A giant struma histologically confirmed as a medullary carcinoma with multiple systemic bone metastasis].
abstract: Reported is the case of a 46 year old woman with no significant family medical history, who presented a neck tumor that she had had for about ten years. This large tumor was noted on her admittance to hospital due to a bone fracture. She subsequently underwent a resection of this giant neck tumor. A histologic examination of the specimen revealed a medullary carcinoma of the follicular variety. Silver impregnation by the Grimelius method caused a positive reaction, and an electron-microscopic examination revealed round, electron-dense, endocrine granules about 195 nm in diameter, Immunohistochemically, the carcinoembryonic antigen (CEA) and the presence of calcitonin proved the cells to be cancerous.
authors: Dept. of Second Surgery, Toyama Med. and Pharmaceutical Univ.
authors: M
authors: M
authors: Saito
authors: Y
authors: Y
authors: Karaki
authors: T
authors: T
authors: Kasagi
authors: T
authors: T
authors: Kushibuchi
authors: S
authors: S
authors: Tajika
authors: K
authors: K
authors: Tazawa
authors: M
authors: M
authors: Fujimaki
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D002116:Calcitonin / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D002272:Carcinoembryonic Antigen; D002116:Calcitonin