Biochemical aspects of the hormonal therapy of endometrial adenocarcinoma.
This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, polyamine concentration, and the activity of ornithine decarboxylase (ODC), i.e. the first enzyme in polyamine synthesis, were compared before and after the 30/day treatment. The modifications induced by MPA are discussed and related to the pathological picture in an attempt to determine the characteristics of responding tumors.
Lanza
A
A
Dept. B of Obstetrics and Gynaecologic Institute, Univ. of Torino, Italy.
Colombatto
S
S
Bellino
R
R
Re
A
A
Tessarolo
T
T
Ferraris
G
G
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D005958:Glucosephosphates; D011073:Polyamines; D019298:Glucose-6-Phosphate; D009955:Ornithine Decarboxylase; D008525:Medroxyprogesterone