[Ultrastructure of the parietal region of the brain after selective damage of the serotoninergic system].
The selective lesion of the afferent serotoninergic system by means of intracisternal administration of 5,7-dihydroxytryptamine produces certain structural rearrangements in a part of cellular elements and in various parts of the neuropil of the neocortical parietal area. The deficiency of serotoninergic innervation influences the metabolic processes. This is evident from the change in the structure of protein synthesizing apparatus in a number of postsynaptic neurons. It is possible that the structural rearrangements observed in the serotoninergic and in the conjugated to it mediatory systems make the base of functional disorders in the neocortex and are accompanied with certain changes in the integrative activity of the brain.
Kucherenko
R P
RP
Otellin
V A
VA
D015116:5,7-Dihydroxytryptamine / Q000506:poisoning*; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D002799:Cholinergic Fibers / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D003712:Dendrites / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D010296:Parietal Lobe / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin
Ul'trastruktura kory temennoĭ oblasti bol'shogo mozga v usloviiakh selectivnogo povrezhdeniia serotoninergicheskoĭ sistemy.