[Tumor control-significance of the stem cell number].
The stem cell number is one of the important factor determining tumor control radiation dose. It is now clear that 50% tumor cell doses in various rodent tumors inversely related to their tumor control radiation doses. Roles of radiation-sterilized cells on the clonogenicity of survived stem cells are controversial, and should be explored by future research. Methodological innovations are also desirable to measure the stem cell number in human tumors.
Ando
K
K
Division of Clinical Research, Hospital, National Institute of Radiological Sciences.
Fukuda
H
H
Arai
T
T
Nakano
T
T
D000818:Animals; D002452:Cell Count; D002455:Cell Division; D002470:Cell Survival / Q000528:radiation effects*; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000528:radiation effects*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy