Debridement of experimental full-thickness skin burns of rats with enzyme fractions derived from pineapple stem.
A limited in vivo study using 12 rats with full-thickness skin burns injuries was carried out. The animals were treated 24 h postburn with two newly discovered enzyme fractions derived from the stem of the pineapple (Ananas comosus). The results indicated that even debridement of the injury could be effected rapidly (within 4 h). Although the details of enzyme formulation and clinical application have yet to be established, these findings clearly suggest that two enzyme fractions from pineapple stem have potential as non-surgical debriding agents.
Rowan
A D
AD
Biochemistry Department, Strangeways Research Laboratory, Cambridge, UK.
Christopher
C W
CW
Kelley
S F
SF
Buttle
D J
DJ
Ehrlich
H P
HP
D000818:Animals; D002056:Burns / Q000628:therapy*; D003546:Cysteine Endopeptidases / Q000008:administration & dosage / Q000627:therapeutic use; D003646:Debridement / Q000379:methods*; D005638:Fruit / Q000201:enzymology*; D008297:Male; D010865:Pilot Projects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology*
D003546:Cysteine Endopeptidases; C066609:comosain; C057808:ananain