Pervasive developmental disorder in monozygotic twins.
Monozygotic twin brothers were diagnosed as having pervasive developmental disorder, not otherwise specified (DSM-III-R). They show different levels of cognitive and behavioral impairment, consistent with a greater number of suboptimal pre-, peri-, and postnatal factors present in one of the twins. This case study lends support to the hypothesis that genetic factors are of importance in the expression of a pervasive developmental disorder, but that degree of developmental delay, its severity, and certain clinical features may be determined by nongenetic suboptimal pre-, peri-, and postnatal events.
Vukicevic
J
J
Department of Pediatrics, Stanford University School of Medicine, California.
Siegel
B
B
D001321:Autistic Disorder / Q000175:diagnosis / Q000523:psychology; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002675:Child, Preschool; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005838:Genotype; D006801:Humans; D008297:Male; D012307:Risk Factors; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology