title: Evolution of isopenicillin N synthase genes may have involved horizontal gene transfer.
abstract: The isopenicillin N synthase genes from three fungal species, three Gram-positive species, and one Gram-negative bacterial species share an unusually high sequence similarity. A phylogenetic analysis was carried out to determine which type of evolutionary scenario best accounts for this similarity. The most plausible scenario is one in which a horizontal gene-transfer event, from the prokaryotes to the eukaryotes, occurred at a time close to the divergence between the Gram-positive and the Gram-negative bacteria.
authors: Interdisciplinary Program for Fostering Excellence, Tel Aviv University, Ramat Aviv, Israel.
authors: G
authors: G
authors: Landan
authors: G
authors: G
authors: Cohen
authors: Y
authors: Y
authors: Aharonowitz
authors: Y
authors: Y
authors: Shuali
authors: D
authors: D
authors: Graur
authors: D
authors: D
authors: Shiffman
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology / Q000235:genetics*; D005075:Biological Evolution; D005658:Fungi / Q000201:enzymology / Q000235:genetics*; D005798:Genes, Bacterial; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000235:genetics*; D014162:Transfection
chemical_list: D010088:Oxidoreductases; C038370:isopenicillin N synthetase