Accessibility and possibility of elimination of breast epithelium: the theoretical possibility of preventing breast carcinoma through destruction of the epithelium of origin.
Two characteristics of breast biology appear to constitute weak points in the fight against breast carcinoma. First, the epithelium from which breast carcinoma arises is of relatively easy accessibility, as it lines cavities which are in close communication with the outside. Second, the elimination of breast epithelium can be tolerated by the organism. Theoretically, breast carcinoma may be prevented by destroying breast epithelium through the injection of an agent into the ductal orifices at the nipple. This strategy appears relatively easy to perform in comparison with conventional strategies, which have not given reliable results. Therefore the possibility presented here should not be neglected.
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D001940:Breast / Q000033:anatomy & histology* / Q000254:growth & development / Q000502:physiology; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004848:Epithelium / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008954:Models, Biological