[New results with delayed progression in the cell cycle of solid squamous cell carcinomas of the head-neck area after single and fractionated irradiation with cobalt-60 and neutrons].
Cell-kinetic changes of xenograft tumors have been investigated after radiation therapy at different times. The growth-locking lasted clearly longer compared with the one of cell cultures. Against this was there were no cell-kinetic changes between centrum and borders of the xenograft tumors. Adding hypoxic sensitizers a further prolongation of the G2M block could be attained. Fractionated irradiation did not adduce qualitative or quantitative changes of the cell kinetics. There was also no difference between low LET and high LET radiation.
Wagner
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Klinik und Poliklink für Strahlentherapie, Universität-Münster.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002453:Cell Cycle / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D009502:Neutrons / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D013997:Time Factors; D014183:Transplantation, Heterologous
D003037:Cobalt Radioisotopes; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; C033815:pimonidazole
Neue Ergebnisse der Progressionsverzögerung im Generationszyklus von soliden Plattenepithelkarzinomen der Kopf-Hals-Region nach Einzel- und fraktionierter Bestrahlung mit Kobalt 60 und Neutronen.