Iron, radiation, and cancer.
Increased iron content of cells and tissue may increase the risk of cancer. In particular, high available iron status may increase the risk of a radiation-induced cancer. There are two possible mechanisms for this effect: iron can catalyze the production of oxygen radicals, and it may be a limiting nutrient to the growth and development of a transformed cell in vivo. Given the high available iron content of the western diet and the fact that the world is changing to the western model, it is important to determine if high iron increases the risk of cancer.
Stevens
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Pacific Northwest Laboratory, Richland, WA 99352.
Kalkwarf
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D000818:Animals; D001682:Biological Availability; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D004032:Diet / Q000009:adverse effects; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007501:Iron / Q000009:adverse effects* / Q000493:pharmacokinetics; D000090463:Iron Deficiencies; D007953:Leukemia, Radiation-Induced / Q000209:etiology / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D011836:Radiation Tolerance; D012307:Risk Factors
D005609:Free Radicals; D006861:Hydrogen Peroxide; D007501:Iron; D010100:Oxygen