title: [Development of the concept of antidotes: the contribution of clinical toxicology].
abstract: The clinical study of antidotes has been limited until the recent development of Clinical Toxicology Centers where rare but demonstrative observations were collected and a critical approach for the validation of therapy organized. After the period of setting of respiratory assistance in coma due to acute intoxication by psychotropic drugs, the knowledge of biochemical receptors for toxic molecules and the production of antagonistic molecules allows the setting of drugs with unquestionable efficacity according to the accumulation of data in CTC and to an international collaboration and consensus program. Some pharmacological research considered as necessary have permitted the discovery of new situations as frequent cyanhydric intoxications due to plastic furniture during home fires. The progress in antibodies-antidotes bioformation and pharmaceutical production is necessary to antagonize some acute and often lethal intoxications like these due to colchicine and paraquat.
authors: Hôpital Fernand Widal, Paris.
authors: E
authors: E
authors: Fournier
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D006801:Humans; D011041:Poisoning; D014116:Toxicology
chemical_list: D000931:Antidotes
vernacular_title: Evolution de la conception des antidotes: l'apport de la toxicologie clinique.