title: Capsaicin inhibits responses of fine afferents from the knee joint of the cat to mechanical and chemical stimuli.
abstract: In adult anaesthetized cats we studied the effects of capsaicin on the responses of single slowly conducting afferents of the knee joint to mechanical and chemical stimuli (bradykinin). An intra-arterial bolus injection of capsaicin into the joint reduced or abolished the responses to passive movements of the joint in 8 of 19 afferents and the responses to intra-arterially administered bradykinin in 10 of 11 units. Capsaicin was usually effective at 10(-4) to 10(-3) M. The inhibition was predominantly observed in nociceptive afferents, whereas most low threshold units were not desensitized.
authors: Physiologisches Institut, Universität Würzburg, F.R.G.
authors: X
authors: X
authors: He
authors: K
authors: K
authors: Schepelmann
authors: H G
authors: HG
authors: Schaible
authors: R F
authors: RF
authors: Schmidt
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors; D002211:Capsaicin / Q000494:pharmacology*; D002415:Cats; D006614:Hindlimb; D007269:Injections, Intra-Arterial; D007596:Joints / Q000294:innervation; D009475:Neurons, Afferent / Q000187:drug effects*; D013314:Stress, Mechanical
chemical_list: D002211:Capsaicin; D001920:Bradykinin