[Small intestine transplantation--a causal therapy in short bowel syndrome].
The problems of surgical technique, graft physiology and immunological reactions in small-bowel transplantation have been investigated in extended animal experiments. In these experiments, the fundamentals of a successful clinical application of small-bowel transplantation could be laid. A successful human small-bowel transplantation could be carried out by the Kiel Group for the first time in 1988. A graft which had been removed from a related donor showed a complete adaptation after 22 months, so that the patient became completely independent from parenteral nutrition. After that, in several cases small-bowel and combined liver and small-bowel transplantation have been carried out. Thus, the clinical small-bowel transplantation represents the causal therapy of short-bowel syndrome and should be developed in further clinical trials.
Deltz
E
E
Klinikum der Christian-Albrecht-Universität zu Kiel.
Schroeder
P
P
Schweizer
E
E
Gundlach
M
M
Gebhardt
H
H
Hansmann
M L
ML
D000328:Adult; D000818:Animals; D005260:Female; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents; D007421:Intestine, Small / Q000637:transplantation*; D051381:Rats; D012778:Short Bowel Syndrome / Q000601:surgery*; D014181:Transplantation Immunology
D007166:Immunosuppressive Agents
Die Dünndarmtransplantation--eine kausale Therapie des Kurzdarmsyndroms.