[Obesity, body fat distribution and the incidence of breast, cervical, endometrial and ovarian carcinomas].
The connection of body fat distribution (BFD) and the risk of developing mammary, cervical, endometrial or ovarian carcinoma was ascertained for 163 patients with carcinoma (mean age 49.9 [19-78] years) and 489 controls of comparable age and body-mass index. BFD was expressed as the ratio of waist and hip circumference (T/H ratio of 0.822 vs 0.781 and 0.826 vs 0.789, respectively; P less than 0.01). In premenopausal women with mammary or cervical carcinoma and in all postmenopausal women BFD was similar to that in the control subjects. A common cause of android obesity and ovarian or endometrial carcinoma may be a reduction of sex-hormone-binding globulins with an elevated serum level of free androgens and oestrogens.
Sönnichsen
A C
AC
Medizinische Klinik II, Klinikum Grosshadern, Universität München.
Lindlacher
U
U
Richter
W O
WO
Schwandt
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008593:Menopause; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology*; D014594:Uterine Neoplasms / Q000453:epidemiology*
Adipositas, Körperfettverteilung und Inzidenz von Mamma-, Zervix-, Endometrium- und Ovarialkarzinomen.