In vivo activity of orally administered antibiotics and chemotherapeutics against acute septicaemic pasteurellosis in rabbits.
Different antibiotics and chemotherapeutics were tested for therapeutic efficacy in rabbits, in an experimental model using a Pasteurella multocida strain which causes hyperacute septicaemia in this animal species. Only enrofloxacin, administered in the drinking water at a concentration of 50-100 mg/l cured the rabbits, provided that a daily intake of 5 mg/kg body weight was achieved. The other drugs tested (tetracycline, spiramycin, erythromycin and a combination of sulfamerazine with trimethoprim), at doses recommended for rabbits, showed little or no activity at all, with the exception of chloramphenicol, which was only partially effective.
Okerman
L
L
Faculty of Veterinary Medicine, Gent, Belgium.
Devriese
L A
LA
Gevaert
D
D
Uyttebroek
E
E
Haesebrouck
F
F
D042462:4-Quinolones; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D010326:Pasteurella Infections / Q000188:drug therapy / Q000662:veterinary*; D015363:Quinolones; D011817:Rabbits; D018805:Sepsis / Q000188:drug therapy / Q000662:veterinary*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D002701:Chloramphenicol