title: Variation of benzbromarone elimination in man--a population study.
abstract: The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals (97%) in a population study were found to eliminate benzbromarone rapidly. In one subject the 24 h benzbromarone plasma concentration was very similar to that observed in the individual who had been more fully characterized. Four participants gave intermediate results. The data are compatible with a bimodal or trimodal distribution of different benzbromarone elimination phenotypes.
authors: Abteilung Klinische Pharmakologie, Medizinischen Klinik, Universität Heidelberg, FRG.
authors: I
authors: I
authors: Walter-Sack
authors: U
authors: U
authors: Gresser
authors: M
authors: M
authors: Adjan
authors: I
authors: I
authors: Kamilli
authors: A
authors: A
authors: Ittensohn
authors: J X
authors: JX
authors: de Vries
authors: E
authors: E
authors: Weber
authors: N
authors: N
authors: Zöllner
mesh_terms: D000328:Adult; D001553:Benzbromarone / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype
chemical_list: D001553:Benzbromarone