A variant Philadelphia chromosome (Ph1) positive chronic myelocytic leukemia.
A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs.
Haruta
Y
Y
Department of Internal Medicine, Kochi Municipal Central Hospital, Japan.
Takahashi
I
I
Sekito
N
N
Miyamoto
K
K
Shimamoto
M
M
Wakita
Y
Y
Kikkawa
K
K
Nakamura
T
T
Seto
T
T
Yamashita
J
J
D000368:Aged; D005260:Female; D015321:Gene Rearrangement; D014644:Genetic Variation; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic