Postoperative recovery of mitochondrial function of the human liver graft procured and preserved with University of Wisconsin (UW) solution.
Changes in arterial blood ketone body ratio (KBR) were investigated in 47 human liver transplantations. Of the 20 grafts preserved with University of Wisconsin (UW) solution, 10 had a cold preservation period of less than 10 h (UWS group) and 10 of more than 10 h (UWL group). In 27 other cases, grafts were preserved with EuroCollins (EC) solution for less than 10 h (EC group). In the EC group, KBR increased over 0.7 within 6 h after reperfusion of the graft in 17 cases (63%) and within 24 h in 7 cases (26%). In the 3 other cases, KBR failed to recover, and these patients underwent retransplantation. In the UW group, KBR recovered within 6 h in 13 cases (65%) and within 24 h in 7 cases (35%). There were no significant differences between the UWS and UWL groups. It is shown that the mitochondrial function of liver grafts preserved with UW solution can be well maintained even after extended preservation periods of more than 10 h.
Osaki
N
N
Clinic for Abdominal and Transplantation Surgery, Medizinische Hochschule Hannover, Federal Republic of Germany.
Ringe
B
B
Bunzendahl
H
H
Taki
Y
Y
Gubernatis
G
G
Oellerich
M
M
Kuse
E R
ER
Burdelski
M
M
Uemoto
S
S
Kimoto
M
M
D000241:Adenosine; D000493:Allopurinol; D005978:Glutathione; D006801:Humans; D006982:Hypertonic Solutions; D007328:Insulin; D007657:Ketone Bodies / Q000097:blood*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008930:Mitochondria, Liver / Q000502:physiology*; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011184:Postoperative Period; D011887:Raffinose; D012996:Solutions; D013997:Time Factors
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D007328:Insulin; D007657:Ketone Bodies; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose