[Serial change of perilymphatic potassium ion concentration in the scala tympani after introducing KCl-solution into the guinea pigs' tympanic cavity].
Characteristic nystagmus similar to the Meniere's attack could be observed after introducing KCl solution into the tympanic cavity of guinea pigs. To confirm the fact that this nystagmus was provoked by the high perilymphatic potassium ion concentration, the K+ activity of perilymph was recorded serially through the K+ specific microelectrode inserted into the scala tympani. The rapid increment of K+ activity reached maximum at 120 minutes after introducing KCl solution, and then it decreased gradually to a half of the maximum activity. However, such change of perilymphatic potassium ion concentration was not observed by introducing sucrose solution as control.
Ikeno
K
K
Department of Otolaryngology, Hirosaki University School of Medicine.
D000818:Animals; D004432:Ear, Middle; D006168:Guinea Pigs; D007477:Ions; D010498:Perilymph / Q000378:metabolism*; D011188:Potassium / Q000493:pharmacokinetics*; D011189:Potassium Chloride / Q000008:administration & dosage*; D012533:Scala Tympani / Q000378:metabolism*
D007477:Ions; D011189:Potassium Chloride; D011188:Potassium