title: Whole blood quality assurance control samples for forensic toxicology.
abstract: Pilot studies were undertaken to examine the feasibility of preparing freeze-dried whole blood samples containing drugs of interest to be used as assay controls. The availability of such samples will enable analysts and laboratory managers to monitor analytical performance. A pilot batch of freeze-dried blood containing five compounds of forensic significance and a blank blood sample were prepared for reconstitution to 2.5-mL aliquots. Samples of each of these preparations were distributed to 55 laboratories in the USA and UK for analysis. A summary of the results is presented along with comments on the feasibility of producing freeze-dried whole blood samples for use in forensic toxicology.
authors: Central Research and Support Establishment, Home Office Forensic Science Service, Reading, Berkshire, United Kingdom.
authors: M D
authors: MD
authors: Osselton
authors: M
authors: M
authors: Japp
authors: S I
authors: SI
authors: Weston
authors: E A
authors: EA
authors: Mather
authors: V
authors: V
authors: Spiehler
authors: R
authors: R
authors: Barlow
authors: A
authors: A
authors: Moore
mesh_terms: D000818:Animals; D003975:Diazepam / Q000097:blood; D005554:Forensic Medicine; D005612:Freeze Drying; D006736:Horses; D006801:Humans; D008691:Methadone / Q000097:blood; D008694:Methamphetamine / Q000097:blood; D009020:Morphine / Q000097:blood; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011786:Quality Control; D013048:Specimen Handling; D014116:Toxicology
chemical_list: D004364:Pharmaceutical Preparations; D008694:Methamphetamine; D009020:Morphine; D003975:Diazepam; D008691:Methadone