Glottic cancer: results of treatment with radiotherapy in air and hyperbaric oxygen.
This paper is a retrospective analysis of 397 patients with glottic cancer, in which 240 patients were treated in air, and 157 patients in a hyperbaric oxygen chamber (HBO). The three principal dose/time schedules in air and HBO are contrasted, and shown to be iso-effective. The local tumour control rates show a significant improvement in favor of HBO: Stage I, 10%; Stage II, 37%; Stage III, 73%. Morbidity rates are explored, and suggest that the increased local control rate is not attained at the cost of an increased morbidity rate. The planning of the treatment, the preparation of the patient, and any subsequent complications are described. Treatment in the HBO chamber in a busy department has been shown to be a safe and routine procedure.
Whittle
R J
RJ
Department of Radiotherapy, St. Bartholomew's Hospital, UK.
Fuller
A P
AP
Foley
R R
RR
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005931:Glottis; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000628:therapy; D008722:Methods; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate