Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome.
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan N alpha-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1'-ethylidenebis[tryptophan]. This novel amino acid may be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.
Mayeno
A N
AN
Lin
F
F
Foote
C S
CS
Loegering
D A
DA
Ames
M M
MM
Hedberg
C W
CW
Gleich
G J
GJ
D002851:Chromatography, High Pressure Liquid; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009132:Muscles; D010146:Pain / Q000139:chemically induced*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013577:Syndrome; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity*
C070372:1,1'-ethylidene bis(tryptophan); D014364:Tryptophan