[Caused of intensified lipid peroxidation in the blood of patients with viral hepatitis B].
The tissue oxygen concentration, the serum antioxidant system state and the serum malondialdehyde (MDA) concentration were studied in patients with hepatitis B. The good correlations were studied in patients with hepatitis B. The good correlations between MDA concentration in patients serum and the oxygen concentration in tissues (R-0.79), and the cytoplasmic enzymes activity (R-0.75 for lactate dehydrogenase; R-0.75 for alanine transferase) were found. On the other hand, it was shown an antioxidant activity decrease of ceruloplasmin-transferrin system in patients serum. It is proposed, that the tissue hypoxia and the decrease of the serum antioxidant activity are the general factors leading to the MDA accumulation in the serum of patients with hepatitis B.
Boldyrev
N A
NA
Kozlov
A V
AV
Zmyzgova
A V
AV
Azizova
O A
OA
Roslyĭ
I M
IM
Musarov
A L
AL
Vladimirov
Iu A
IuA
D000293:Adolescent; D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis; D003593:Cytoplasm / Q000201:enzymology; D006509:Hepatitis B / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D010101:Oxygen Consumption; D014168:Transferrin / Q000032:analysis
D014168:Transferrin; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D002570:Ceruloplasmin
Prichiny intensifikatsii perekisnogo okisleniia lipidov v syvorotke krovi u bol'nykh virusnym gepatitom B.