title: The effect of verapamil on the anti-tumour action of mitozantrone and doxorubicin against renal carcinoma cells in vitro.
abstract: Ten renal carcinomas were established in culture and their sensitivity to mitozantrone +/- verapamil, as measured by (75Se) selenomethionine incorporation, was studied. The 5 tumours with spread beyond the kidney were those in which sensitivity to mitozantrone was enhanced by verapamil. With 4 of the 10 tumours and 1 further carcinoma, similar experiments were performed using doxorubicin. This drug was more active, its anti-tumour action being related to concentration. Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added.
authors: Department of Surgery, Royal Infirmary, Bristol.
authors: T
authors: T
authors: Lai
authors: A P
authors: AP
authors: Morgan
authors: P J
authors: PJ
authors: Smith
authors: M O
authors: MO
authors: Symes
mesh_terms: D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008942:Mitoxantrone / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012645:Selenomethionine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D009363:Neoplasm Proteins; D004317:Doxorubicin; D012645:Selenomethionine; D008942:Mitoxantrone; D014700:Verapamil