[Enhancers, DNA loops and stable complexes: a mechanism of transcription activation].
A recurrent theme in molecular biology is that of "action at a distance" along DNA. We consider various mechanisms of action of transcriptional enhancers as a well-characterised example of interaction between widely separated DNA-bound proteins. The role of promoter- and enhancer-binding proteins in the formation of a stable promoter complex, and the mechanisms of interaction between multiple activatory DNA sequences is also discussed.
Studitskiĭ
V M
VM
Khrapko
K R
KR
D000494:Allosteric Regulation; D000818:Animals; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005057:Eukaryotic Cells; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D015534:Trans-Activators / Q000235:genetics*; D014158:Transcription, Genetic
D015534:Trans-Activators
Enkhansery, petli DNK i stabil'nye kompleksy: mekhanizm aktivatsii transkriptsii.