Urine methylhistamine concentrations before and after chloroquine in healthy black subjects.
Urine concentrations of methylhistamine were measured in 11 subjects who experienced itching with chloroquine ('itchers') and in 14 who did not itch ('non-itchers'). In each group, urine methylhistamine concentrations were significantly greater at 12, 24 and 36 h after ingestion of 1 g chloroquine phosphate than before. There was no significant difference between itchers and non-itchers as regards urine methylhistamine concentrations at any time-point. Furthermore, there was no correlation between urine methylhistamine concentration and degree of pruritus in itchers. The findings suggest that histamine may be released by chloroquine, but it is unlikely to be the main cause of chloroquine-induced pruritus.
Ezeamuzie
C I
CI
Department of Pharmacology, College of Medicine, University of Port Harcourt, Nigeria.
Igbigbi
P S
PS
Asomugha
L
L
Ambakederemo
A W
AW
Abila
B
B
Assem
E S
ES
D000328:Adult; D000704:Analysis of Variance; D044383:Black People; D002738:Chloroquine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008761:Methylhistamines / Q000652:urine*; D011537:Pruritus / Q000139:chemically induced*
D008761:Methylhistamines; D002738:Chloroquine