title: Radiochromatography in pharmaceutical and biomedical analysis.
abstract: Recent advances in the chromatographic analysis of radiolabelled compounds are discussed, with emphasis on the optimization of radioactivity detection in modern chromatographic techniques. Applications are mentioned only infrequently. The state-of-the-art of common radioactivity detection methods is reviewed, as well as promising new detection principles. The latter include flow-through liquid scintillation counting of reversed-phase column eluates based on post-column extraction and solvent segmentation, flow-through heterogeneous counting using a flow cell constructed from axially aligned scintillation fibres, flow cells especially constructed for the detection of beta-emitting radioisotopes in capillary zone electrophoresis, position-sensitive analysers employed in radio planar chromatography and, finally 14C atom counting (as opposed to 14C decay counting) by accelerator mass spectrometry.
authors: Netherlands Energy Research Foundation, Petten.
authors: A C
authors: AC
authors: Veltkamp
mesh_terms: D001345:Autoradiography / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004586:Electrophoresis; D006801:Humans; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011868:Radioisotopes; D012588:Scintillation Counting
chemical_list: D004364:Pharmaceutical Preparations; D011868:Radioisotopes