title: Decreased uptake and binding of 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography.
abstract: Positron emission tomography of the brain following intravenous injection of (+) (R) and (-) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of 11C-nicotine in Azheimer brains may be of diagnostic value.
authors: Department of Pharmacology, University of Uppsala, Sweden.
authors: A
authors: A
authors: Nordberg
authors: P
authors: P
authors: Hartvig
authors: A
authors: A
authors: Lilja
authors: M
authors: M
authors: Viitanen
authors: K
authors: K
authors: Amberla
authors: H
authors: H
authors: Lundqvist
authors: Y
authors: Y
authors: Andersson
authors: J
authors: J
authors: Ulin
authors: B
authors: B
authors: Winblad
authors: B
authors: B
authors: Långström
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D006801:Humans; D008875:Middle Aged; D009538:Nicotine / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D009538:Nicotine