Computer simulation of a cytosolic calcium oscillator.
A new interpretation of existing data permits us to define a model capable of accounting for agonist-induced Ca2+ oscillations in the cytosol of electrically non-excitable cells. The model only requires one Ca2+ store, which contains Ca2+ channels controlled by inositol 1,4,5-trisphosphate and Ca2+. Computer simulations may generate different experimentally observed patterns of Ca2+ oscillations.
Swillens
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Institut de Recherche Interdisciplinaire, Université Libre de Bruxelles, Belgium.
Mercan
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D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D003198:Computer Simulation; D003600:Cytosol / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D005246:Feedback; D015544:Inositol 1,4,5-Trisphosphate / Q000494:pharmacology; D008954:Models, Biological
D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium