[Stability of metronidazole, prednisolone and dexamethasone in urea-containing Elacutan W dermatologic agent].
Metronidazole was investigated in the basic dermatologic agent Elacutan W to improve the topical therapy of rosacea. The suitability of that basic dermatologic agent was verified for metronidazole, prednisolone and dexamethasone by stability tests (UV-spectroscopy, pH) and by in-vitro-liberation-measurements (membrane method). The drugs are stable for a period of 100 days.
Heyde
R
R
Zentralapotheke, Bereichs Medizin, Martin-Luther-Universität Halle-Wittenberg.
Dorsch
S
S
Heidenreich
S
S
Illig
G
G
D003907:Dexamethasone / Q000032:analysis*; D004338:Drug Combinations; D004355:Drug Stability; D008795:Metronidazole / Q000032:analysis*; D009824:Ointments / Q000032:analysis; D011239:Prednisolone / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D014508:Urea / Q000032:analysis*
D004338:Drug Combinations; D009824:Ointments; C053467:elacutan; D008795:Metronidazole; D003907:Dexamethasone; D014508:Urea; D011239:Prednisolone
Zur Stabilität von Metronidazol, Prednisolon und Dexsamethason im harnstoffhaltigen Dermatikum Elacutan W.