Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.
Parathyroid hormone-related protein (PTHrP) is known to be a causative factor in humoral hypercalcemia of malignancy. A polyclonal rabbit antiserum directed against the amino-terminal region of the protein and immunoperoxidase methods have been used to locate the presence of PTHrP in a series of 102 consecutive invasive breast tumors removed surgically from normocalcemic women. Positive PTHrP staining was detected in 60% of the tumors but not in the accompanying normal breast tissue. Positive staining was related to the progesterone receptor status of the tumor (P = 0.039) and to the prognostic index of the patient (P = 0.046) and not to estrogen receptor status, patient age, tumor size, histological grade, or nodal status.
Southby
J
J
St. Vincent's Institute of Medical Research, St. Vincent's Hospital, Victoria.
Kissin
M W
MW
Danks
J A
JA
Hayman
J A
JA
Moseley
J M
JM
Henderson
M A
MA
Bennett
R C
RC
Martin
T J
TJ
D000367:Age Factors; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D044162:Parathyroid Hormone-Related Protein; D011379:Prognosis; D014176:Protein Biosynthesis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone