Stimulation of cell division by argon and Nd:YAG laser trabeculoplasty in cynomolgus monkeys.
Although laser treatment of the trabecular meshwork is the most common form of surgery for glaucoma, the tissue response to this therapy is still incompletely understood. We applied argon or Nd:YAG laser to the trabecular meshwork of six monkeys. Cell division was identified by injecting tritiated thymidine into the anterior chamber 24 hr after laser application. Autoradiography of tissue sections revealed significantly more labelled cells in eyes treated with laser than in the untreated controls. In addition, cells in neighboring tissues such as iris, ciliary body and sclera showed labelling in association with laser application. Furthermore, comparison of argon-induced lesions with those caused by pulsed Nd:YAG suggests that there are quantitative and qualitative differences in the response of trabecular meshwork and surrounding tissues to these two forms of laser energy.
Dueker
D K
DK
Mason Institute of Ophthalmology, University of Missouri-Columbia.
Norberg
M
M
Johnson
D H
DH
Tschumper
R C
RC
Feeney-Burns
L
L
D000818:Animals; D000867:Anterior Chamber / Q000166:cytology / Q000528:radiation effects; D001128:Argon; D001345:Autoradiography; D002455:Cell Division / Q000528:radiation effects; D002924:Ciliary Body / Q000166:cytology / Q000528:radiation effects; D005260:Female; D007498:Iris / Q000166:cytology / Q000528:radiation effects; D053685:Laser Therapy; D008252:Macaca fascicularis; D008297:Male; D008940:Mitotic Index / Q000528:radiation effects; D009354:Neodymium; D012590:Sclera / Q000166:cytology / Q000528:radiation effects; D013936:Thymidine; D014129:Trabecular Meshwork / Q000166:cytology / Q000528:radiation effects* / Q000601:surgery; D014130:Trabeculectomy
D009354:Neodymium; D001128:Argon; D013936:Thymidine