Inhibition of fatty acid-supported mitochondrial respiration by cyclosporine.
We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity.
Lemmi
C A
CA
Department of Anatomy and Cell Biology, UCLA 90024.
Miller
R L
RL
Rajfer
J
J
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010172:Palmitoylcarnitine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D005227:Fatty Acids; D010172:Palmitoylcarnitine