Effect of concurrent sucralfate administration on the absorption of erythromycin.
To determine the influence of sucralfate on the absorption of erythromycin, prior to evaluating its efficacy in decreasing erythromycin-associated gastrointestinal (GI) intolerance, we assessed pharmacokinetic parameters in six healthy adult volunteers. Erythromycin ethylsuccinate administered alone or with sucralfate as a single dose was compared. Sucralfate did not significantly alter the elimination rate constant, half-life, or area under the curve for erythromycin ethylsuccinate. It is therefore unlikely that efficacy of erythromycin ethylsuccinate will be altered when sucralfate is coadministered.
Miller
L G
LG
Department of Family Medicine, Baylor College of Medicine, Houston, TX 77005.
Prichard
J G
JG
White
C A
CA
Vytla
B
B
Feldman
S
S
Bowman
R C
RC
D000328:Adult; D004347:Drug Interactions; D004917:Erythromycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013392:Sucralfate / Q000494:pharmacology*
D013392:Sucralfate; D004917:Erythromycin