[Antibiotic and specific immunoglobulin G in the treatment of E. coli sepsis in mice previously given steroids].
Experimental E. coli sepsis was constituted in two groups of mice. One of the groups have been immunosuppressed by steroid therapy of ten days (group A) and the other group was normal (group B). Ceftriaxone and Ig G, prepared by vaccinating rabbits with the same strain of E. coli, were used in therapy. The results of the therapy in both were compared. The mortality rate of mice on Ig G therapy was % 70 in group A and % 80 in group B and that on ceftriaxone therapy % 60 and % 50, respectively. The mortality rate was % 30 in both groups with Ig G + ceftriaxone therapy. There wasn't any significance between these. On this research, the treatment of antibiotic together with Ig G decreased the mortality rate. The statistical value of the mortality rate among the treatment groups was not found significant.
Bakir
M
M
Cumhuriyet Universitesi, Tip Fakültesi Infeksiyon Hastaliklari Bilim Dali, Sivas.
Doğanay
M
M
Dökmetaş
I
I
D000818:Animals; D002443:Ceftriaxone / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004927:Escherichia coli Infections / Q000628:therapy*; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D051379:Mice; D011817:Rabbits; D013256:Steroids / Q000276:immunology*
D007074:Immunoglobulin G; D013256:Steroids; D002443:Ceftriaxone
Steroid verilen farelerde oluşturulan deneysel E. coli sepsisinde antibiyotik ile beraber immünoglobulin G tedavisi.