title: Oestrogen and progesterone receptors in carcinoma of the cervix.
abstract: Oestrogen (ER) and progesterone (PR) receptors have been measured in 102 cervical carcinomas. With positive levels defined as concentrations exceeding 20 fmol/mg protein for cytoplasmic receptor and/or 200 fmol/mg DNA for nuclear receptor, 24% of tumours were dual receptor positive and 51% were dual receptor negative. The majority of adenocarcinomas (81%: 13/16) expressed ER (P less than 0.001) though only 54% (7/13) of these tumours co-expressed PR. There was a significant correlation between tumours positive for ER and those arising in premenopausal women (P = 0.011), with good or moderate differentiation (P = 0.027) and of smaller size (P = 0.025). Median follow-up is 19 months. Apart from advanced stage, tumour bulk (greater than 5 cm) was the only parameter associated with inferior progression-free survival, and most larger tumours were of advanced stage. No prognostic significance could be detected for receptor status.
authors.affiliation: CRC Department of Medical Oncology, University of Glasgow, UK.
authors.forename: M
authors.initials: M
authors.lastname: Harding
authors.forename: J
authors.initials: J
authors.lastname: McIntosh
authors.forename: J
authors.initials: J
authors.lastname: Paul
authors.forename: R P
authors.initials: RP
authors.lastname: Symonds
authors.forename: N
authors.initials: N
authors.lastname: Reed
authors.forename: T
authors.initials: T
authors.lastname: Habeshaw
authors.forename: M
authors.initials: M
authors.lastname: Stewart
authors.forename: R E
authors.initials: RE
authors.lastname: Leake
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry; D002294:Carcinoma, Squamous Cell / Q000737:chemistry; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone