title: Neuropathological findings in patients with clinical diagnoses of probable Alzheimer's disease.
abstract: To assess prospectively the accuracy of standard antemortem clinical diagnostic criteria for Alzheimer's disease, post-mortem examinations were performed on 25 patients who had met DSM-III criteria for primary degenerative dementia and National Institute of Neurological and Communicative Disorders and Stroke criteria for probable Alzheimer's disease. Seventeen patients (68%) met neuropathological criteria for Alzheimer's disease. Two presenile-onset patients had diffuse neocortical senile plaques of insufficient number for definite Alzheimer's disease. Six patients had non-Alzheimer's disease diagnoses. Five of these six had presenile-onset dementia. These results suggest caution in the antemortem diagnosis of Alzheimer's disease in presenile-onset dementia.
authors.affiliation: Psychiatry Service, American Lake VA Medical Center, Tacoma, WA 98493.
authors.forename: S C
authors.initials: SC
authors.lastname: Risse
authors.forename: M A
authors.initials: MA
authors.lastname: Raskind
authors.forename: D
authors.initials: D
authors.lastname: Nochlin
authors.forename: S M
authors.initials: SM
authors.lastname: Sumi
authors.forename: T H
authors.initials: TH
authors.lastname: Lampe
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: L
authors.initials: L
authors.lastname: Cubberley
authors.forename: E R
authors.initials: ER
authors.lastname: Peskind
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003704:Dementia / Q000175:diagnosis; D003937:Diagnosis, Differential; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009454:Neurofibrils / Q000473:pathology