Allometric analysis of doxycycline pharmacokinetic parameters.
Doxycycline serum concentration-time profiles and elimination half-lives in several species were evaluated by allometric techniques. Doxycycline elimination half-life increased with body weight. Interspecies scaling of total or free doxycycline serum concentration-time profiles was possible by use of Dedrick plots with the exception of doxycycline total concentrations in cats. The observed difference in cats was attributed to more extensive binding to plasma proteins.
Riond
J L
JL
Department of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University.
Riviere
J E
JE
D000818:Animals; D002415:Cats / Q000378:metabolism; D004285:Dogs / Q000378:metabolism; D004318:Doxycycline / Q000493:pharmacokinetics*; D006041:Goats / Q000378:metabolism; D006801:Humans; D051379:Mice / Q000378:metabolism; D012417:Rumen / Q000378:metabolism; D012756:Sheep / Q000378:metabolism; D013552:Swine / Q000378:metabolism
D004318:Doxycycline