Altered pharmacokinetics of cyclosporin in heart-lung transplant recipients with cystic fibrosis.
The cyclosporin dose versus blood concentration relationship for 11 heart-lung transplant recipients with cystic fibrosis was studied retrospectively. Eleven patients, closely matched for age and gender, who received heart-lung transplantation for other diseases were selected as controls. Cystic fibrosis patients received 16.7 (SD 7.2) mg/kg/day of oral cyclosporin compared with 8.2 (SD 1.9) mg/kg/day given to the control patients (p less than 0.01). Nine of the cystic fibrosis patients received higher mean daily doses of cyclosporin. Mean blood cyclosporin concentrations were, however, not significantly different (p = 0.58), and there were no apparent differences in clinical outcome in terms of rejection, infection, and nephrotoxicity in the two groups. The apparent oral clearance of cyclosporin was significantly higher (p less than 0.01) in cystic fibrosis patients. Cyclosporin dosage individualization with the aid of cyclosporin blood concentration measurements is critically important in this subpopulation of heart-lung transplant recipients.
Tan
K K
KK
Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge, England.
Hue
K L
KL
Strickland
S E
SE
Trull
A K
AK
Smyth
R L
RL
Scott
J P
JP
Kelman
A W
AW
Whiting
B
B
Higenbottam
T W
TW
Wallwork
J
J
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D003524:Cyclosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003550:Cystic Fibrosis / Q000097:blood / Q000378:metabolism*; D005260:Female; D016041:Heart-Lung Transplantation; D006801:Humans; D008297:Male; D012189:Retrospective Studies
D003524:Cyclosporins