Experimental studies on half-joint transplantation. Antigenicity of fresh allografted articular cartilage and changes in the articular cartilage.
This study was undertaken to examine the fate of articular cartilage in isogenic half-joint grafts implanted after storage by two-stage freezing. The antigenicity was evaluated quantitatively with regard to humoral and cellular immunological responses: none was seen in allogenic cartilage grafts. In the half-joint transplantations, the antigenicity of the cartilage need not be considered; only the antigenicity of cortical and cancellous bone must be reduced. Histologically, half-joint grafts stored at -196 degrees C were superior to fresh allografts. Two-stage freezing, therefore, appears to be useful for the storage of articular cartilage.
Okada
Y
Y
Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan.
Sakakida
K
K
Fujita
T
T
Mizutani
A
A
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001345:Autoradiography; D002358:Cartilage, Articular / Q000276:immunology / Q000637:transplantation*; D002470:Cell Survival; D003165:Complement System Proteins / Q000276:immunology; D007719:Knee Joint / Q000601:surgery; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014185:Transplantation, Isogeneic
D003165:Complement System Proteins