title: Simulated nasoalveolar palatal defects: a canine model to study bone grafts.
abstract: A simple, surgical technique to create a simulated nasoalveolar palatal defect in the canine is described. The procedure has been performed in 60 canines, and we have not experienced closure of the created clefts. The surgically created clefts had to fulfill five criteria: (1) bilateral maxillary alveolar clefts had to exist in each research animal; (2) each cleft had to have a 1-cm bony width; (3) a demonstrable oronasal communication had to be present; (4) each cleft had to be lined by healthy epithelialized mucosa; (5) there had to be functional teeth adjacent to each side of every cleft.
authors.affiliation: Wilford Hall USAF Medical Center, Lackland Air Force Base, TX 78236-5300.
authors.forename: W J
authors.initials: WJ
authors.lastname: Ehler
authors.forename: R E
authors.initials: RE
authors.lastname: Marx
authors.forename: J H
authors.initials: JH
authors.lastname: Cissik
authors.forename: G B
authors.initials: GB
authors.lastname: Hubbard
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D002972:Cleft Palate / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs