Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid.
In this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamine (NBMA) tumorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 g/kg, EA produced a significant (21-55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. EA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone.
Mandal
S
S
Department of Pathology, Medical College of Ohio, Toledo 43699.
Stoner
G D
GD
D000818:Animals; D000970:Antineoplastic Agents; D001578:Benzopyrans / Q000627:therapeutic use*; D004128:Dimethylnitrosamine / Q000633:toxicity / Q000031:analogs & derivatives; D004610:Ellagic Acid / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004947:Esophagus / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000970:Antineoplastic Agents; D001578:Benzopyrans; D004610:Ellagic Acid; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine