title: Analysis of polyunsaturated fatty acid composition of Strongyloides ratti in relation to development.
abstract: The effect of linolenic acid (C18:3 omega 3) on the development of Strongyloides ratti first-stage larvae (L1) in culture was studied. The fatty acid composition of S. ratti free-living generations was analyzed by gas chromatography. L1 had abundant linoleic acid (C18:2 omega 6) but its proportion decreased with development. On the contrary, eicosapentaenoic acid (C20:5 omega 3) and C20:4 omega 3 were prominent in the filariform larva (L3). Because C20:5 omega 3 is generally synthesized from C18:3 omega 3 via C20:4 omega 3, the high ratio of C20:5 omega 3/C18:3 omega 3 of L3 in all the free-living generations suggested that polyunsaturated fatty acid metabolism, particularly the omega-3 series, and eicosanoids produced had important roles in the development of S. ratti L1.
authors.affiliation: Department of Parasitic Diseases, Kumamoto University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Minematsu
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Uji
authors.forename: H
authors.initials: H
authors.lastname: Okabe
authors.forename: M
authors.initials: M
authors.lastname: Korenaga
authors.forename: I
authors.initials: I
authors.lastname: Tada
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D008297:Male; D013321:Strongyloides / Q000032:analysis* / Q000254:growth & development
chemical_list: D005231:Fatty Acids, Unsaturated