Accessory cell function in asymptomatic human immunodeficiency virus-infected patients.
Peripheral blood mononuclear cells from human immunodeficiency virus seropositive (HIV+) individuals who did not exhibit symptoms of acquired immunodeficiency syndrome (AIDS) (Walter Reed Stage 1 patients) were tested for accessory cell function for presentation of recall antigens to autologous T lymphocytes and for presentation of HLA alloantigens to T lymphocytes from healthy, HIV- donors. Neither experimental model indicated a defect in accessory cell function at this early stage after HIV infection, although our study does not exclude the possibility of accessory cell dysfunction at a later stage of AIDS development.
Clerici
M
M
Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Stocks
N I
NI
Zajac
R A
RA
Boswell
R N
RN
Shearer
G M
GM
D000938:Antigen-Presenting Cells / Q000276:immunology*; D002478:Cells, Cultured; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis
D007376:Interleukin-2