[Clinicopathological and immunohistochemical study of 118 cases of rhabdomyosarcoma].
118 cases of rhabdomyosarcoma are reported. Specimens from 30 of these cases were stained with Masson Trichrome and phosphotunstic acid haemotoxylin. 36 cases were studied immunohistochemically by PAP, and ABC methods. Specific antibodies against myoglobin, desmin and vimentim were used. Positive immunostaining for myoglobin and desmin was found in 72.7% and 55.5% of the cases studied respectively. The positivity was dependent on the degree of cell differentiation. Results suggest that immunohistochemistry is a useful tool for the diagnosis of poorly differentiated rhabdomyosarcomas. Cross--striations were found in only 6 of the thirty cases (20%). It is now generally accepted that demonstration of cross--striations is not essential for the diagnosis; nevertheless, the characteristic features of fibrillary material arranged in whorls around the nucleus are of diagnostic significance. Histologically, it is also believed that searching for early differentiated rhabdomyoblasts combined with the histological pattern is of vital importance for an accurate diagnosis.
Li
S H
SH
Department of Pathology, West China University of Medical Sciences, Chengdu.
Zhang
X H
XH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000473:pathology*