[Secretion of prostaglandin E by cells of human thymoma MOLT-4 and their sensitivity to cytotoxic action of NK-cells].
It was demonstrated that thymoma cells of MOLT-4 strain which are the standard cell targets of cytotoxic tests (CT) with NK-cells are rapidly releasing PGE in contact with NK-cells; as a consequence the depression of cytotoxic activity (CTA) of NK-cells takes place. The significant decrease of CTA of NK-cells was observed when the absolute number of MOLT-4 target cells participating in CT increased. Correspondingly the susceptibility of MOLT-4 cells as a target in CT is decreased. The levels of susceptibility of MOLT-4 cells to NK-cell cytotoxicity and CTA of NK-cells retained, or even increased, after the pretreatment of MOLT-4 cells with indomethacin.
Kliuchareva
T E
TE
Matveeva
V A
VA
Kushlinskiĭ
N E
NE
Uvarova
E N
EN
D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D011458:Prostaglandins E / Q000378:metabolism*; D013945:Thymoma / Q000276:immunology / Q000378:metabolism*; D013953:Thymus Neoplasms / Q000276:immunology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011458:Prostaglandins E; D007213:Indomethacin
Sekretsiia prostaglandina E kletkami timomy cheloveka MOLT-4 i ikh chuvstvitel'nost' k tsitotoksicheskomu deĭstviiu NK-kletok.