title: Regional radiotherapy as adjuvant treatment for head and neck malignant melanoma. Preliminary results.
abstract: From 1983 through 1988, 83 patients with high-risk cutaneous malignant melanoma (primary lesion thicker than 1.5 mm or palpable lymphadenopathy) of the head and neck region were enrolled in a study designed to assess the efficacy of a few large doses of radiation (24 to 30 Gy in 4 to 5 fractions). The actuarial 2-year locoregional control rates for the three groups were 95%, 90%, and 83%, respectively. Corresponding survival rates were 80%, 71%, and 69%. The majority of failures were due to distant metastases. Locoregional control rates were better than those reported earlier with surgery alone for comparable patients. The treatment morbidity was minimal.
authors.affiliation: Department of Clinical Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: K K
authors.initials: KK
authors.lastname: Ang
authors.forename: R M
authors.initials: RM
authors.lastname: Byers
authors.forename: L J
authors.initials: LJ
authors.lastname: Peters
authors.forename: M H
authors.initials: MH
authors.lastname: Maor
authors.forename: C D
authors.initials: CD
authors.lastname: Wendt
authors.forename: W H
authors.initials: WH
authors.lastname: Morrison
authors.forename: D H
authors.initials: DH
authors.lastname: Hussey
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000401:mortality / Q000532:radiotherapy*