Effect of probucol on the lipid composition of blood plasma, erythrocyte ghosts and liver membranes in mice.
1. Probucol treatment of mice (0.6 g/kg) induced a decrease of cholesterol (CH) and total phospholipids (PLs) in blood plasma, erythrocyte ghosts, liver plasma and microsomal membranes. 2. The incorporation of [14C]acetate in the microsomal lipids of probucol-treated mice was lowered by 23% compared to controls. 3. Probucol administration induced a reduced specific activity of PLs, CH and CH esters, whereas in triacylglycerols it was augmented. 4. Phospholipase A2 and neutral sphingomyelinase activities were not enhanced, indicating that the catabolism of the membrane PL was not elevated.
Markovska
T T
TT
Central Laboratory of Biophysics, Bulgarian Academy of Sciences, Sofia.
Neicheva
T N
TN
Momchilova-Pankova
A B
AB
Koumanov
K S
KS
Infante
R
R
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002788:Cholesterol Esters / Q000097:blood; D004910:Erythrocyte Membrane / Q000737:chemistry*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry*; D008563:Membrane Lipids / Q000097:blood / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D011341:Probucol / Q000494:pharmacology*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D002788:Cholesterol Esters; D008055:Lipids; D008563:Membrane Lipids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D010741:Phospholipases A; D054467:Phospholipases A2; D013108:Sphingomyelin Phosphodiesterase; D011341:Probucol; D019342:Acetic Acid