title: Prognostic factors and the significance of cytologic grading in invasive squamous cell carcinoma of the vulva: a clinicopathologic study.
abstract: Clinical staging, tumor size, histologic differentiation, cytologic grading, depth of stromal invasion, and vascular channel involvement by tumor cells were studied in 42 patients with invasive squamous cell carcinoma of the vulva who were treated with radical vulvectomy and inguinal-femoral lymphadenectomy. All parameters were found to correlate well in predicting groin node metastasis. Cytological grading was found to be more significant compared to histologic grading in regard to nodal metastasis (P less than 0.02). No patient with cytologic or histologic grade 1 tumor and less than 5 mm stromal invasion was found to have nodal metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cincinnati, Ohio 45267-0526.
authors.forename: N
authors.initials: N
authors.lastname: Husseinzadeh
authors.forename: T
authors.initials: T
authors.lastname: Wesseler
authors.forename: D
authors.initials: D
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Schellhas
authors.forename: W
authors.initials: W
authors.lastname: Nahhas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D014846:Vulvar Neoplasms / Q000473:pathology*