title: [Significance of single-dose captopril test in the differential diagnosis of primary aldosteronism].
abstract: The captopril test was used to make a differential diagnosis of various types of primary aldosteronism. After captopril, there was no change in the activity of the renin-angiotensin-aldosterone system only in the group of patients with aldosterone-producing adenomas in a histological variant of "adenoma and atrophy". The findings suggest that aldosterone secretion regulation is autonomic in the adenoma unassociated with the function of the renin-angiotensin-aldosterone system only in the case of isolated adenoma with a histological variant of adenoma and atrophy. In patients with aldosterone-producing adenomas in the presence of the variant "adenoma and hyperplasia", aldosterone secretion retains sensitivity to the renin-angiotensin-aldosterone system as in patients with idiopathic hyperplasia and hypertensive disease, which indicates that it is possible to differentiate isolated "adenoma and atrophy" from hypertensive disease and idiopathic hyperplasia, despite its combination with tumor by using the captopril test.
authors.forename: S E
authors.initials: SE
authors.lastname: Ustinova
authors.forename: I A
authors.initials: IA
authors.lastname: Uchitel'
authors.forename: R I
authors.initials: RI
authors.lastname: Sokolova
authors.forename: V A
authors.initials: VA
authors.lastname: Popov
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000175:diagnosis; D000328:Adult; D002216:Captopril; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis* / Q000209:etiology; D006973:Hypertension / Q000150:complications / Q000175:diagnosis; D008297:Male; D012084:Renin-Angiotensin System
chemical_list: D002216:Captopril
vernacular_title: Znachenie testa s odnorazovym priemom kaptoprila v differentsial'noĭ diagnostike pervichnogo al'dosteronizma.