Amyotrophic lateral sclerosis in a patient with fragile X syndrome.
Fragile X syndrome is a common cause of mental retardation. We report the clinical and pathologic features of a patient with fragile X syndrome who developed amyotrophic lateral sclerosis (ALS) at a relatively young age. Although the occurrence of these 2 diseases could be a mere coincidence, the development of ALS in this patient might be related to the chromosomal aberration of fragile X syndrome.
Desai
H B
HB
Department of Neurology, University Hospital, Saskatoon, Saskatchewan, Canada.
Donat
J
J
Shokeir
M H
MH
Munoz
D G
DG
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology*; D001921:Brain / Q000473:pathology; D005600:Fragile X Syndrome / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D012729:Sex Chromosome Aberrations / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology