Exposure-response relationships in asthma caused by tetrachlorophthalic anhydride.
Four patients with asthma caused by occupational exposure to tetrachlorophthalic anhydride (TCPA) had dust-challenge tests that used eight different levels of TCPA exposure. Measurements of TCPA in the test-cubicle air ranged from 1.3 to 961.1 micrograms/m3. The higher exposures provoked definite late or dual asthmatic responses. Smaller, but statistically significant, responses were observed at low exposures. The late asthmatic-response area had a linear relation to the logarithm of TCPA exposure, but the immediate asthmatic response was less closely related to exposure.
Venables
K M
KM
Department of Occupational Medicine, National Heart and Lung Institute, Brompton Hospital, London, England.
Newman Taylor
A J
AJ
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001985:Bronchial Provocation Tests / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010795:Phthalic Acids / Q000009:adverse effects*; D010796:Phthalic Anhydrides / Q000009:adverse effects* / Q000032:analysis; D012882:Skin Tests
D000395:Air Pollutants, Occupational; D004391:Dust; D010795:Phthalic Acids; D010796:Phthalic Anhydrides; C009409:tetrachlorophthalic anhydride; D006632:Histamine