[Regulation by myelopid of immunoglobulin production in culture of human peripheral blood lymphocytes in normal and secondary immunodeficient state].
The effect of myelopid (MP) on the in vitro antibody production in man in norm and secondary postoperative immunodeficiency state, as well as the effect of immunocorrection therapy with MP on PWM-induced antibody production in LPB cultures during postoperative period have been studied. A stimulating effect of MP on IgA and IgM production in LPB cultures on the 8th day after an operation were only observed in case of PWM stimulation. In early postoperative period, the LPB cultures of patients did not respond to PWM and were not sensitive to MP. In case of immunocorrection with MP in postoperative period, a noticeable response to PWM was observed in vitro on the 8th day, after the operation, whereas sensitivity to MP in vitro was not observed.
Vlasenko
R Ia
RIa
Stepanenko
R N
RN
Koval'chuk
L V
LV
D028341:Activins; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001853:Bone Marrow / Q000276:immunology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002478:Cells, Cultured; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D011183:Postoperative Complications
D000276:Adjuvants, Immunologic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D009842:Oligopeptides; D010455:Peptides; C044147:activin B; D028341:Activins; C048617:myelopeptides
Reguliatsiia mielopidom produktsii immunoglobulinov v kul'ture limfotsitov perifericheskoĭ krovi cheloveka v norme i pri vtorichnom immunodefitsitnom sostoianii.