title: A pharmacologic approach to dosage intensification.
abstract: Using standard pharmacologic concepts, it is possible to show that changes in schedule will influence the relative influx of drug between various normal tissues and tumor. A line of investigation is discussed that should lead to optimization of influx into tumor tissue while minimizing uptake into dose limiting normal tissues.
authors.affiliation: Department of Medicine, Thomas Jefferson School of Medicine, Philadelphia, PA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Weiss
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002470:Cell Survival / Q000187:drug effects; D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological
chemical_list: D000970:Antineoplastic Agents