title: Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.
abstract: Genetically mast cell-deficient WBB6F1-W/Wv mice showed an apparent defect in manifestation of the resistance against larval Haemaphysalis longicornis ticks, but their serum IgE levels increased more than 100-fold after the second tick infestation. Immune sera obtained from the WBB6F1-W/Wv mice were adoptively transferred to the other WBB6F1-W/Wv mice which had received intracutaneous injections of WBB6F1-+/+ mouse-derived cultured mast cells. Because the resistance against ticks was detectable only when both mast cells and IgE antibodies were available, immediate hypersensitivity reaction appeared to have a physiologic role in the manifestation of the resistance against H. longicornis ticks.
authors.affiliation: Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kiso
authors.forename: S
authors.initials: S
authors.lastname: Hirota
authors.forename: H
authors.initials: H
authors.lastname: Ushio
authors.forename: Y
authors.initials: Y
authors.lastname: Kannan
authors.forename: M
authors.initials: M
authors.lastname: Azuma
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000276:immunology*; D007814:Larva; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D012867:Skin / Q000276:immunology / Q000473:pathology; D013984:Tick Infestations / Q000276:immunology* / Q000473:pathology; D013987:Ticks / Q000276:immunology
chemical_list: D000906:Antibodies; D007073:Immunoglobulin E