[Contribution of parachor to the study of structure-activity relationship. Aromatase inhibitor activity of androstenediones].
Parachor has been used extensively in physical organic chemistry for structure determination, but rarely in quantitative correlation of structure and biological activity. The purpose of this study is the contribution of the parachor in the QSAR of androstenediones derivatives and their inhibition of aromatase enzyme. Good correlations were obtained for two classes of steroids inhibitors of oestrogens biosynthesis.
Trinh
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HV
Laboratoire de Physique, UFR de Pharmacie, Université Joseph-Fourier Grenoble I, La Tronche.
Luu-Duc
C
C
Pitta
I
I
Galdino
S
S
D000735:Androstenedione / Q000494:pharmacology*; D001141:Aromatase / Q000737:chemistry; D047072:Aromatase Inhibitors; D008433:Mathematics; D013329:Structure-Activity Relationship
D047072:Aromatase Inhibitors; D000735:Androstenedione; D001141:Aromatase
Contribution du parachor à l'étude de corrélations structure-activité. Activité inhibitrice d'aromatase des androstènediones.