title: Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease.
abstract: Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.
authors.affiliation: Department of Psychological Medicine, Glasgow University, Glasgow, Scotland.
authors.forename: D
authors.initials: D
authors.lastname: Montaldi
authors.forename: D N
authors.initials: DN
authors.lastname: Brooks
authors.forename: J H
authors.initials: JH
authors.lastname: McColl
authors.forename: D
authors.initials: D
authors.lastname: Wyper
authors.forename: J
authors.initials: J
authors.lastname: Patterson
authors.forename: E
authors.initials: E
authors.lastname: Barron
authors.forename: J
authors.initials: J
authors.lastname: McCulloch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000523:psychology; D001921:Brain / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D014057:Tomography, X-Ray Computed
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime