[Biological effects of Gelatinol during artificial circulation].
The levels of plasma fibronectin (FN) were investigated in patients during heart surgery using artificial circulation. Plasma FN levels were assessed by electroimmunoassay (rocket immunoelectrophoresis) and bioassay (aggregation of gelatin-coated microparticles). The application of gelatinol in hemodilution++ composition led to the depletion of bioactive Fn from 140 to 0 micrograms/ml, whereas immunoreactive Fn levels were slightly elevated. The in vitro experiments have shown that gelatinol inhibits the aggregation of gelatinol-coated microparticles and chemiluminiscence of neutrophils, stimulated by gelatin-coated particles. Gelatinol elimination from hemodilution++ composition resulted in the reduction of postoperative mortality and accelerated tissue reparation.
Zinkevich
O D
OD
Medvedev
V N
VN
Safina
N A
NA
Kharrasov
A F
AF
Muginov
M A
MA
D001021:Aortic Valve / Q000601:surgery; D005112:Extracorporeal Circulation; D005353:Fibronectins / Q000037:antagonists & inhibitors / Q000097:blood*; D005780:Gelatin / Q000008:administration & dosage*; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery*; D006438:Hemodilution; D006801:Humans; D066298:In Vitro Techniques; D007430:Intraoperative Care; D008943:Mitral Valve / Q000601:surgery
D005353:Fibronectins; C014567:Gelatinol; D005780:Gelatin
Biologicheskie éffekty zhelatinolia pri iskusstvennom krovoobrashchenii.