Urinary neopterin excretion in patients with uterine sarcomas.
Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell-mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was significantly higher (P less than 0.0001) than that obtained in women with benign myomas and healthy controls. Furthermore, a significant correlation of normal or raised neopterin concentrations with the clinical course of disease was found. These data suggest that urinary neopterin measurement might be a useful immunologic marker for women with uterine sarcomas.
Fuith
L C
LC
Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
Fuchs
D
D
Hausen
A
A
Hetzel
H
H
Reibnegger
G
G
Werner
E R
ER
Wachter
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D019798:Neopterin; D012509:Sarcoma / Q000473:pathology / Q000652:urine*; D014594:Uterine Neoplasms / Q000473:pathology / Q000652:urine*
D001708:Biopterins; D019798:Neopterin