[Scintigraphic monitoring of chondro-protective therapy of finger polyarthritis].
A pilot study in patients with osteoarthritis of fingers was done to clarify the question, whether abnormal joints in bone scanning can predict degenerative changes in X-rays and if scintigraphy is of help in monitoring therapy with chondroprotective medications. 2 groups of 7 patients with symptomatic osteoarthritis of fingers were treated either with galvanic bath alone or in combination with Rumalon-injections for 6 weeks. After therapy the number of abnormal joints in bone scan and number of tender joints was found reduced in both groups, a decrease of the mean circumference of joints was only seen in the Rumalon-group. After 1 year an increase of degenerative signs in X-rays was demonstrated in both groups. But the number of tender joints was smaller in the Rumalon-group than in controls. For abnormal joints in bone scanning a high positive value was calculated regarding to signs of osteoarthritis in radiographs. But no major information in monitoring the chondroprotective efficacy of the medicament was given by bone scanning.
Ammer
K
K
Knechtsberger
P
P
Atefie
K
K
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000187:drug effects; D004164:Diphosphonates; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011379:Prognosis; D011877:Radionuclide Imaging; D013667:Technetium; D017556:Technetium Compounds; D014020:Tissue Extracts / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004164:Diphosphonates; D017556:Technetium Compounds; D014020:Tissue Extracts; C000562:Rumalon; D013667:Technetium; C029045:technetium Tc 99m diphosphonate
Szintigraphische Kontrolle einer chondroprotektiven Therapie von Fingerpolyarthrosen.