Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland.
Dietary glucarate has previously been shown to inhibit chemical carcinogen-induced rat mammary tumorigenesis. It is demonstrated in this paper that in the mammary gland of the female Sprague-Dawley rat, feeding glucarate at a dose of 70 mmol/kg AIN76A diet for 2 weeks beginning at 35 days of age, markedly reduces [3H]thymidine labeling. Specific histochemical staining for beta-glucuronidase is used to show that the glucarate diet fed to rats for 2-4 weeks inhibits beta-glucuronidase activity in the mammary gland and has a marked antiproliferative effect on mammary epithelium. Glucarate may inhibit rat mammary carcinogenesis, in part, by changing the proliferative status of the target organ.
Walaszek
Z
Z
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957.
Hanausek
M
M
Sherman
U
U
Adams
A K
AK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002136:Calcium, Dietary / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004032:Diet; D005260:Female; D005937:Glucaric Acid / Q000494:pharmacology*; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013400:Sugar Acids / Q000494:pharmacology*
D002136:Calcium, Dietary; D013400:Sugar Acids; D005966:Glucuronidase; D005937:Glucaric Acid