Curtailment of autoimmunity following parabiosis with a normal partner.
The development of thyroiditis in DA rats that had been exposed to 131I in utero was prevented by parabiosis to normal, syngeneic partners. However, if the normal partner had received sublethal irradiation before parabiosis, thyroid implants placed in either partner were likely to manifest spontaneous thyroiditis.
McCullagh
P
P
John Curtin School of Medical Research, Australian National University, Canberra.
D000818:Animals; D015551:Autoimmunity / Q000528:radiation effects; D005260:Female; D007457:Iodine Radioisotopes; D008297:Male; D010227:Parabiosis; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000637:transplantation; D013967:Thyroiditis, Autoimmune / Q000276:immunology* / Q000517:prevention & control; D014916:Whole-Body Irradiation
D007457:Iodine Radioisotopes