[Distortion of the pressor response to adrenaline in hepatectomized and tumor-bearing rats].
Similar distortion of hypertensive response to epinephrine occurred in sarcoma-45-bearing rats, Walker carcinosarcoma-bearing rats, and hepatectomized rats. The response in the last-named was distorted on the 3rd postoperative day. The hypertensive response to epinephrine was restored after the regenerative processes in the liver were completed (7th-10th postoperative day). Distortion of the response in carcinosarcoma-bearing rats was detected beginning from the 4th day after transplantation in some of the animals and on the 14th day in the others; in all sarcoma 45-bearing rats distortion occurred by the 20th day. The pressor response was distorted usually under conditions of pharmacological block of the alpha-adrenergic receptors. It is assumed that in extensive proliferation of normal and neoplastic cells, substances exerting a selective blocking effect on the alpha-adrenoceptors of the blood vessels penetrate into circulation.
Gebevanishvili
M D
MD
Gogitidze
N M
NM
Sulakvelidze
M T
MT
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000502:physiology*; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology*
D004837:Epinephrine
Izvrashchenie pressornoĭ reaktsii na adrenalin u gepatéktomirovannykh krys i u zhivotnykh-opukholenositeleĭ.