title: Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine.
abstract: The pharmacokinetics of nifedipine and its primary oxidised metabolite, M-I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co-trimoxazole. Following pretreatment with co-trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half-life, or area under the plasma concentration-time curve of either nifedipine or M-I, nor on the blood pressure response to nifedipine.
authors.affiliation: Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.
authors.forename: C
authors.initials: C
authors.lastname: Edwards
authors.forename: S
authors.initials: S
authors.lastname: Monkman
authors.forename: S
authors.initials: S
authors.lastname: Cholerton
authors.forename: M D
authors.initials: MD
authors.lastname: Rawlins
authors.forename: J R
authors.initials: JR
authors.lastname: Idle
authors.forename: R E
authors.initials: RE
authors.lastname: Ferner
mesh_terms: D000328:Adult; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics*; D011292:Premedication; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009543:Nifedipine