title: [Fatal pulmonary edema in a pernicious malaria attack].
abstract: A case is reported of a 40-year-old woman presenting with cerebral malaria complicated by an adult respiratory distress syndrome (ARDS). The patient was admitted to the intensive care unit in a coma, scored 5 on the Glasgow scale. Plasmodium falciparum parasitaemia was, at the time, 50%. A continuous intravenous quinine infusion (25 mg.kg-1.day-1) was started, together with the required symptomatic treatment. Blood was transfused because of increasing anaemia (haemoglobin 60 g.l-1). After 24 h, parasitaemia was 12%, consumption of clotting factors broke out (prothrombine 43%, fibrin degradation products greater than 40 micrograms.ml-1, platelets 45 G.l-1). Hypoxaemia (PaO2 = 46 mmHg) and hypocapnia (PaCO2 = 32 mmHg) became obvious, together with bilateral diffuse alveolar infiltrates on chest X-ray. Haemodynamic data suggested non cardiogenic oedema: PEEP 20 cm H2O, cardiac output 6.15 l.min-1, mean pulmonary arterial pressure 35 mmHg, pulmonary wedged pressure 15 mmHg. The hypoxia worsened and the patient died on the 15th day after associated with high levels of parasitaemia. Several reports have suggested that it may be related to increased capillary permeability. Initial fluid overload should therefore be avoided. Parenteral quinine remains the mainstay of treatment, because of its rapid schizonticidal activity. Although exchange transfusion seems to be a valuable adjunct to chemotherapy, it requires further assessment.
authors.affiliation: Département d'Anesthésie-Réanimation, Centre Hospitalier, La Roche-sur-Yon.
authors.forename: B
authors.initials: B
authors.lastname: Rioult
authors.forename: J B
authors.initials: JB
authors.lastname: Mérit
authors.forename: N
authors.initials: N
authors.lastname: Varache
authors.forename: M
authors.initials: M
authors.lastname: Trichet
mesh_terms: D000328:Adult; D000818:Animals; D001929:Brain Edema / Q000209:etiology; D003128:Coma / Q000209:etiology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008288:Malaria / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D010963:Plasmodium falciparum; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology; D011803:Quinine / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000503:physiopathology
chemical_list: D011803:Quinine
vernacular_title: Oedème pulmonaire lésionnel d'évolution mortelle au cours d'un accès pernicieux palustre.