Protein C deficiency in insulin-dependent diabetes: a hyperglycemia-related phenomenon.
In 30 insulin-dependent diabetic patients protein C (PC) antigen and PC activity were significantly lower than those of matched control healthy subjects. An inverse correlation between fasting plasma glucose and both PC concentration and activity was present in diabetics, while a direct correlation between PC concentration and PC activity was observed. Induced hyperglycemia in diabetic and normal subjects was able to decrease both PC antigen levels and PC activity, and heparin reversed in part this effect. In diabetic patients euglycemia obtained by insulin infusion restored to normal the depressed PC levels. Heparin did not alter both the basal PC concentration and activity in healthy controls. These data stress the major role of hyperglycemia in determining PC decrease in diabetics, and suggest that PC reduction is probably associated to hyperglycemia-enhanced thrombin formation.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Universita di Napoli, Italy.
Quatraro
A
A
Dello Russo
P
P
Marchi
E
E
Barbanti
M
M
Milani
M R
MR
Giugliano
D
D
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D008297:Male; D011486:Protein C / Q000276:immunology; D020151:Protein C Deficiency
D001786:Blood Glucose; D011486:Protein C; D006493:Heparin