title: Lipoprotein particles in homozygous familial hypercholesterolemic patients treated with portacaval shunt and LDL apheresis.
abstract: Lipoprotein particles containing apolipoproteins (Apo) were studied by enzyme-linked-immunosorbent assay in two homozygous familial hypercholesterolemic patients (1 male and 1 female) with portacaval shunts, and in controls. Total Apo B, total cholesterol and LDL cholesterol were increased in both patients while complex Apo B containing particles, Lp CIII: B, were not increased in these FH patients. The dextran-sulfate cellulose columns (Liposorber LA-40) had an excellent adsorption selectivity and adsorption capacity for lipoprotein particles containing Apo B and a minimum adsorption capacity in Apo AI and Apo AII-containing particles. This apheresis technique selectively depleted plasma of atherogenic Apo B-containing particles with a minimal loss of antiatherogenic Apo AI-containing particles.
authors.affiliation: Service de Néphrologie, CHU Lille, France.
authors.forename: D
authors.initials: D
authors.lastname: Gairin
authors.forename: F
authors.initials: F
authors.lastname: Monard
authors.forename: C
authors.initials: C
authors.lastname: Cachera
authors.forename: J M
authors.initials: JM
authors.lastname: Bard
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
authors.forename: P
authors.initials: P
authors.lastname: Duriez
authors.forename: A
authors.initials: A
authors.lastname: Tacquet
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
mesh_terms: D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001781:Blood Component Removal; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000628:therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011167:Portacaval Shunt, Surgical; D013997:Time Factors
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins