[Aggregation inhibiting and anticoagulant effects of oligoamines. 13. Improvement in the storage of whole blood and erythrocyte suspensions with oligoamines].
The impairment of the functions of red blood cells or their destruction during storage can be delayed or even inhibited by oligoamines especially RE 1492 (N,N',N''-Tris-(4-phenylbutyl)benzene-1,3,5-trimethanamine). When citrated whole blood (WB) is stored at 4 degrees C for 7 d half of the red blood cells (RBC) have lost their ability to form rouleaux. Addition of 100 mumols/L RE 1492 maintains 50% reaggregability up to day 28th of storage. When citrated WB is stored at 37 degrees C the reaggregability has declined to 40 percent after 10 h. With 100 mumols/L RE 1492 no reduction of this property is observed up to 48 h. These results are correlated with the maintainance of the discocyte form of RBC and a persistent filtrability of RBC suspensions through a 5 microns microporous membrane. With 100 mumols/L RE 1492 only one fifth of the haemolysis of untreated WB occurs. The efflux of potassium ions from RBC into the blood plasma during a 72 h storage is bisected by RE 1492. The binding of oxygen to RBC remains unchanged.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin.
Kaehler
H
H
Kuberka
H
H
D000925:Anticoagulants / Q000494:pharmacology*; D001793:Blood Preservation; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D011188:Potassium / Q000097:blood
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D011073:Polyamines; C067017:RE 1492; D011188:Potassium
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 13.Mitt.: Verbesserung der Lagerfähigkeit von Vollblut und Erythrocytensuspensionen durch Oligoamine.