title: The proportion altering factor (PAF) and the in vitro transdifferentiation of isolated striated muscle of jellyfish into nerve cells.
abstract: The effect of proportion altering factor (PAF) on the transdifferentiation of isolated striated muscle into RFamide-positive nerve cells was investigated. The factor reduces incorporation of 3H-thymidine into replicating DNA; the effect is concentration-dependent and reversible. Transdifferentiation to nerve cells increases by up to 60% if PAF is applied shortly before or at the time of initiation of DNA synthesis. When treatment was terminated 4 h before the start of S-phase or when PAF was applied at the peak of S-phase no increase in nerve cell formation was observed.
authors.affiliation: Zoological Institute, University of Basel, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Schmid
authors.forename: G
authors.initials: G
authors.lastname: Plickert
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects / Q000502:physiology; D005407:Flagella / Q000187:drug effects / Q000502:physiology; D009132:Muscles / Q000166:cytology* / Q000187:drug effects; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D016196:S Phase / Q000187:drug effects / Q000502:physiology; D037401:Scyphozoa / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
chemical_list: D001685:Biological Factors; D014316:Tritium; D004247:DNA; D013755:Tetradecanoylphorbol Acetate; D013936:Thymidine