Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.
Effects of FKS-508 (AF102B; cis-2-methylspiro (1,3-oxathiolane-5,3')-quinuclidine), a novel M1-selective agonist, on central muscarinic responses in mice were examined in comparison with oxotremorine. FKS-508 was slightly less potent (6 times) in reversal of scopolamine-induced amnesia (passive avoidance failure), but far less potent (260 and 55 times) in producing hypothermia and tremor than oxotremorine. These results show that the selective M1 agonist FKS-508 differentiates highly between the central muscarinic effects.
Nakahara
N
N
Research Institute of Life Science, Snow Brand Milk Products Co. Ltd., Tochigi, Japan.
Fujise
N
N
Kawanishi
G
G
Mizobe
F
F
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology*; D011812:Quinuclidines / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D013876:Thiophenes
D011812:Quinuclidines; D011976:Receptors, Muscarinic; D013876:Thiophenes; D010095:Oxotremorine; C059240:cevimeline