Effects of some adenosine analogs on morphine-induced analgesia and tolerance.
1. The analogs of adenosine D- and L-phenylisopropyladenosine (D- and L-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, D- and L-PIA did not affect the process.
Contreras
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Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.
Germany
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A
Villar
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D015762:2-Chloroadenosine / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D004357:Drug Synergism; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010660:Phenylisopropyladenosine / Q000494:pharmacology
D000700:Analgesics; D015762:2-Chloroadenosine; D010660:Phenylisopropyladenosine; D009270:Naloxone; D002110:Caffeine; D009020:Morphine; D000241:Adenosine