Hematologic manifestations in pediatric HIV infection: severe anemia as a prognostic factor.
The hematologic profile of 100 symptomatic children infected by the human immunodeficiency virus (HIV) was evaluated and compared to HIV uninfected infants with transplacentally acquired maternal anti-HIV antibodies, and to HIV-negative infants born to i.v. drug-abusing HIV uninfected mothers. Anemia was present in 94% of HIV-infected infants and was a major predictor of disease progression. In 91% of patients having a hematocrit (HcT) less than 25%, the disease course was rapidly fatal. Leukopenia and thrombocytopenia occurred in 47 and 33% of HIV infected patients, respectively. Neutropenia was most severe in children with opportunistic infections. There was no evidence of suppression of any component of hematopoiesis by passively acquired antibodies to HIV.
Ellaurie
M
M
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Burns
E R
ER
Rubinstein
A
A
D000740:Anemia / Q000453:epidemiology* / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006402:Hematologic Diseases / Q000453:epidemiology / Q000209:etiology*; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007970:Leukopenia / Q000209:etiology; D010198:Pancytopenia / Q000209:etiology; D011379:Prognosis; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000209:etiology
D001323:Autoantibodies; D007074:Immunoglobulin G