title: Intrinsic dissolution rates of tablet filler-binders and their influence on the dissolution of drugs from tablet formulations.
abstract: Intrinsic dissolution rates were determined for different grades of commonly used calcium salt fillers and lactose. Typical tablet formulations of low-dose drugs were studied to determined the influence of this property on drug dissolution.
authors.affiliation: CIBA-GEIGY Corporation, Summit, New Jersey 07901.
authors.forename: A D
authors.initials: AD
authors.lastname: Koparkar
authors.forename: L L
authors.initials: LL
authors.lastname: Augsburger
authors.forename: R F
authors.initials: RF
authors.lastname: Shangraw
mesh_terms: D002118:Calcium; D002626:Chemistry, Pharmaceutical; D002744:Chlorpheniramine / Q000032:analysis; D006852:Hydrochlorothiazide / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007785:Lactose; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D006852:Hydrochlorothiazide; D002744:Chlorpheniramine; D007785:Lactose; D002118:Calcium