[The efficacy and blood concentration monitoring of carbamazepine on mania].
The correlation between efficacy and side effects of carbamazepine and its blood level in 18 patients with mania was reported. All patients had never taken carbamazepine before. The blood lever of carbamazepine was determined by HPLC once a week. Meanwhile, the efficacy and side effects were observed clinically by using scale (BRMS, CGI and TESS). The blood lever of carbamazepine was 8.47 +/- 1.66 micrograms/ml in improved group (70.6 percent), and 4.90 +/- 1.65 micrograms/ml in unimproved group (29.4 percent) when it achieved a steady-state in the fourth week period, their difference was significant (P less than 0.001). There was a positive correlation between efficacy and steady-state blood level of carbamazepine (r = 0.68).
Chen
P J
PJ
Department of Psychiatry Shanghai Medical University.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002220:Carbamazepine