title: [Acute effects of extracorporeal LDL cholesterol and fibrinogen elimination on blood rheology and microcirculation].
abstract: Long-term intermittent heparin-induced extracorporeal low-density lipoprotein (LDL)-cholesterol precipitation was performed in three men - aged 32, 52 and 56 years - with severe familial hypercholesterolaemia and angiographically demonstrated coronary heart disease. This significantly lowered by 65-70% their LDL-cholesterol concentration and by 48-54% their fibrinogen concentration. Fibrinogen elimination reduced plasma viscosity by 13-14% and clearly raised the transcutaneously measured partial pressure of oxygen by 33-50%. Clinically the improved microcirculation achieved a decrease in angina symptoms: the walking distance of the 52-year-old man increased from about 100 m to 4000 m, the daily need of glyceryl trinitrate falling from an average of 12 to 4 aerosol doses.
authors.affiliation: Diabetes-Forschungsinstitut, Universität Düsseldorf.
authors.forename: W
authors.initials: W
authors.lastname: Kleophas
authors.forename: M
authors.initials: M
authors.lastname: Leschke
authors.forename: D
authors.initials: D
authors.lastname: Tschöpe
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Schauseil
authors.forename: Y
authors.initials: Y
authors.lastname: Schottenfeld
authors.forename: B E
authors.initials: BE
authors.lastname: Strauer
authors.forename: F A
authors.initials: FA
authors.lastname: Gries
mesh_terms: D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D001809:Blood Viscosity; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000150:complications / Q000628:therapy*; D005340:Fibrinogen / Q000032:analysis*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012212:Rheology
chemical_list: D008078:Cholesterol, LDL; D005340:Fibrinogen; D006493:Heparin; D010100:Oxygen
vernacular_title: Akute Wirkungen der extrakorporalen LDL-Cholesterin-und Fibrinogen-Elimination auf Blutrheologie und Mikrozirkulation.