Role of adenosine in pathogenesis of anginal pain.
The intravenous infusion of adenosine provokes anginalike chest pain. To establish its origin, an intracoronary infusion of increasing adenosine concentrations was given in 22 patients with stable angina pectoris. During adenosine infusion, 20 patients had chest pain without electrocardiographic signs of ischemia. They all reported that the chest pain was similar to their usual anginal pain. In 10 of the 22 patients adenosine was also infused into the right atrium, but it never produced symptoms at the doses that had provoked chest pain during intracoronary infusion. In seven other patients, the intracoronary adenosine infusion was repeated after intravenous administration of aminophylline, an antagonist of adenosine P1-receptors. Aminophylline decreased the severity of adenosine-induced chest pain (assessed with a visual analog scale) from 42 +/- 22 to 23 +/- 17 mm (p less than 0.002). In the remaining five of the 22 patients, monitoring of blood oxygen saturation in the coronary sinus during intracoronary adenosine administration showed that maximum coronary vasodilation was achieved at doses lower than those responsible for chest pain. A single-blind, placebo-controlled, randomized trial of the effect of aminophylline on exercise-induced chest pain was also performed in 20 other patients with stable angina. Aminophylline, compared with placebo, decreased the severity of chest pain at peak exercise from 67 +/- 21 to 51 +/- 23 mm (p less than 0.02), despite the achievement of a similar degree of ST-segment depression. Finally, the effect of intravenous adenosine was compared in 10 patients with predominantly painful myocardial ischemia and in 10 patients with predominantly silent ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)
Crea
F
F
Cardiovascular Unit, RPMS-Hammersmith Hospital, London, UK.
Pupita
G
G
Galassi
A R
AR
el-Tamimi
H
H
Kaski
J C
JC
Davies
G
G
Maseri
A
A
D000241:Adenosine / Q000494:pharmacology / Q000502:physiology*; D000368:Aged; D000628:Aminophylline / Q000494:pharmacology; D000787:Angina Pectoris / Q000209:etiology* / Q000378:metabolism; D003327:Coronary Disease / Q000503:physiopathology; D003331:Coronary Vessels; D015444:Exercise; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged
D000628:Aminophylline; D000241:Adenosine