title: [The HLA system antigens in patients with cardiovascular diseases].
abstract: Tissue typing applied to the Russian population was used to study distribution of HLA antigens, classes I and II, in patients with essential hypertension (EH), coronary heart disease (CHD), hypertrophic cardiomyopathy (HCMP), dilated cardiomyopathy (DCMP) and virus myocarditis (VM). As control use was made of the data on HLA antigen distribution in 267 healthy persons (donors) of the Russian nationality. The genetic markers of the predisposition to the indicated diseases were revealed: in EH, DR 1 (RR-3.56), DR 4 (RR-2.17); in CHD, B 12 (RR-2.91), DR 1 (RR-3.41), DR 4 (RR-3.14); in HCMP, DR 1 (RR-2.25), DR 4 (RR-3.29); in DCMP, DR 4 (RR-3.90); in VM, DR 3 (RR-5.26), DR 4 (RR-3.51). DR 4 turned out to be the common marker of the predisposition to cardiac diseases. Besides, DR 1 was discovered to be the marker of the predisposition to EH and DR 3 to VM. The data obtained may be of importance for the clinical practice in forming risk groups.
authors.forename: R M
authors.initials: RM
authors.lastname: Khaitov
authors.forename: I S
authors.initials: IS
authors.lastname: Polianskaia
authors.forename: L P
authors.initials: LP
authors.lastname: Alekseev
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility / Q000208:ethnology / Q000276:immunology; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D014586:USSR / Q000208:ethnology
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens
vernacular_title: Antigeny sistemy HLA u bol'nykh s serdechno-sosudistymi zabolevaniiami.