title: [Clinico-laboratory diagnosis of adverse reactions in children to antitubercular drugs in different combinations].
abstract: To clarify side effects in children, which resulted from the treatment of intrathoracic tuberculosis with rifampicin, 72 patients were examined. The findings were compared with those on 58 identical patients who received a routine combination of chemotherapeutic drugs. Hence, on the basis of this observation it was found that there were no differences in the incidence of adverse reactions in the compared groups, though their nature was varying. The children on rifampicin were observed to develop mild liver dysfunction 2.5 times more frequently. Besides, toxic-allergic reactions were recorded in the majority of the patients. The combination of isoniazid and rifampicin was proved to enhance their toxic and allergic effects. Liver dysfunction in the presence of different adverse reactions presented with a higher activity in the blood serum of indicator liver enzymes and its impaired protein-forming function.
authors.forename: K S
authors.initials: KS
authors.lastname: Kazakov
authors.forename: R I
authors.initials: RI
authors.lastname: Zakharova
authors.forename: F T
authors.initials: FT
authors.lastname: Absadykova
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin
vernacular_title: Kliniko-laboratornaia diagnostika pobochnykh reaktsiĭ na protivotuberkuleznye preparaty pri razlichnoĭ kombinatsii u deteĭ.