Intrinsic dissolution rates of tablet filler-binders and their influence on the dissolution of drugs from tablet formulations.
Intrinsic dissolution rates were determined for different grades of commonly used calcium salt fillers and lactose. Typical tablet formulations of low-dose drugs were studied to determined the influence of this property on drug dissolution.
Koparkar
A D
AD
CIBA-GEIGY Corporation, Summit, New Jersey 07901.
Augsburger
L L
LL
Shangraw
R F
RF
D002118:Calcium; D002626:Chemistry, Pharmaceutical; D002744:Chlorpheniramine / Q000032:analysis; D006852:Hydrochlorothiazide / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007785:Lactose; D012995:Solubility; D013607:Tablets
D013607:Tablets; D006852:Hydrochlorothiazide; D002744:Chlorpheniramine; D007785:Lactose; D002118:Calcium