title: Effect of concurrent sucralfate administration on the absorption of erythromycin.
abstract: To determine the influence of sucralfate on the absorption of erythromycin, prior to evaluating its efficacy in decreasing erythromycin-associated gastrointestinal (GI) intolerance, we assessed pharmacokinetic parameters in six healthy adult volunteers. Erythromycin ethylsuccinate administered alone or with sucralfate as a single dose was compared. Sucralfate did not significantly alter the elimination rate constant, half-life, or area under the curve for erythromycin ethylsuccinate. It is therefore unlikely that efficacy of erythromycin ethylsuccinate will be altered when sucralfate is coadministered.
authors.affiliation: Department of Family Medicine, Baylor College of Medicine, Houston, TX 77005.
authors.forename: L G
authors.initials: LG
authors.lastname: Miller
authors.forename: J G
authors.initials: JG
authors.lastname: Prichard
authors.forename: C A
authors.initials: CA
authors.lastname: White
authors.forename: B
authors.initials: B
authors.lastname: Vytla
authors.forename: S
authors.initials: S
authors.lastname: Feldman
authors.forename: R C
authors.initials: RC
authors.lastname: Bowman
mesh_terms: D000328:Adult; D004347:Drug Interactions; D004917:Erythromycin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013392:Sucralfate / Q000494:pharmacology*
chemical_list: D013392:Sucralfate; D004917:Erythromycin