Synthesis and anticonvulsant properties of some arylsuccinate methylpyridylimides.
In reaction of alpha-phenyl, alpha-p-chlorophenyl and alpha-m-chlorophenylsuccinic acid with various aminopyridines, N-pyridyl-substituted succinimides (compounds 1-14) were obtained. These compounds were investigated for their CNS activity. Compounds 1, 2, 5, 6 and 7 displayed anticonvulsant properties in the maximum electroshock test. Compounds 5 and 6 were also active in the pentetrazole test.
Zejc
A
A
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Obniska
J
J
Wilimowski
M
M
Rutkowská
M
M
Witkowska
M
M
Barczyńska
J
J
Kedzierska-Goździk
L
L
Wojewódzki
W
W
Orzechowska-Juzwenko
K
K
Pławiak
T
T
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D000928:Antidepressive Agents / Q000138:chemical synthesis; D002855:Chromatography, Thin Layer; D004357:Drug Synergism; D004597:Electroshock; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000138:chemical synthesis; D012890:Sleep / Q000187:drug effects; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000927:Anticonvulsants; D000928:Antidepressive Agents; D011743:Pyrimidines; D012702:Serotonin Antagonists; D013386:Succinates; D007980:Levodopa; D006591:Hexobarbital; D006916:5-Hydroxytryptophan; D010433:Pentylenetetrazole