title: Levels of insulin-like growth factor I in full- and preterm human milk in comparison to levels in cow's milk and in milk formulas.
abstract: The content of insulin-like growth factor I (IGF-I) in human milk, cow's milk and cow's-milk-based infant formulas was determined by radioimmunoassay. The mean levels of IGF-I in full-term milk and preterm milk 0-4 days post partum 2.2 +/- 0.3 and 2.4 +/- 0.5 ng/mg protein, respectively. The IGF-I content in human milk was not affected by gestational age or birth weight and was constantly excreted up to 10 days post partum. The IGF-I content in human milk was significantly higher than that in cow's milk (0.6 +/- 0.1 ng/mg protein, p less than 0.01). IGF-I was not detected in the milk formulas. The IGF-I in human milk might be absorbed or could act locally in the intestine and may be of importance in the nutrition of neonates.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagashima
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
mesh_terms: D000818:Animals; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007225:Infant Food / Q000032:analysis*; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008892:Milk / Q000737:chemistry*; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy
chemical_list: D007334:Insulin-Like Growth Factor I