Magainin analogs effective against pathogenic protozoa.
The in vitro activities of magainin analogs against Blastocystis hominis, Entamoeba histolytica, and Trypanosoma cruzi were assessed by protozoan morphological integrity and motility. The antiprotozoan activities in descending order were magainin B greater than G greater than H, the same order as the alpha-helix contents of the analogs. Magainin B and G were effective against B. hominis, T. cruzi, and E. histolytica.
Huang
C M
CM
Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107.
Chen
H C
HC
Zierdt
C H
CH
D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D004748:Entamoeba histolytica / Q000187:drug effects*; D056890:Eukaryota / Q000187:drug effects* / Q000648:ultrastructure; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000187:drug effects*
D023181:Antimicrobial Cationic Peptides; D000981:Antiprotozoal Agents; D010455:Peptides; C066945:magainin B; C066946:magainin G; C066947:magainin H