title: Stimulation of dorsal root ganglia and degradation of rabbit annulus fibrosus.
abstract: The authors sought to determine whether narrowing of the intervertebral neural foramen, by itself and in association with vibration, would stimulate the mechanosensitive dorsal root ganglia and result in degradation of proteoglycan and collagen of the annulus fibrosus, as proposed in their working model of dorsal root ganglia-neuropeptide-mediated degeneration of the spinal motion segment. Degradation of proteoglycan and collagen of rabbit annulus was observed when there was narrowing of the neural foremen and the degradation process was accelerated by vibration. Vibration alone, in the absence of structural abnormalities of the spinal motion segment, did not induce matrix degradation probably because of a less pronounced stimulation of the dorsal root ganglia. Biological events similar to those postulated here, fomented by a combination of structural abnormalities and environmental factors, could be involved in human disc degeneration.
authors.affiliation: Department of Orthopaedic Surgery, University of Iowa, Iowa City.
authors.forename: A
authors.initials: A
authors.lastname: Pedrini-Mille
authors.forename: J N
authors.initials: JN
authors.lastname: Weinstein
authors.forename: E M
authors.initials: EM
authors.lastname: Found
authors.forename: C B
authors.initials: CB
authors.lastname: Chung
authors.forename: V K
authors.initials: VK
authors.lastname: Goel
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000503:physiopathology*; D007403:Intervertebral Disc / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000209:etiology* / Q000473:pathology; D008159:Lumbar Vertebrae / Q000473:pathology*; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits; D014732:Vibration / Q000009:adverse effects*
chemical_list: D011509:Proteoglycans; D003094:Collagen