Hypoglycemia, hormones and cytokines in fatal meningococcal septicemia.
A unique case report with sequential measurements of the plasma concentrations of glucoregulatory hormones, interleukin-6 and tumor necrosis factor during development of hypoglycemia in fatal meningococcemia is presented. Hormonal explanations for hypoglycemia like hyperinsulinemia or defective hypoglycemic counter-regulation were excluded. Plasma concentrations of interleukin-6 and tumor necrosis factor were skyhigh. The putative relation between cytokines and hypoglycemia in sepsis is discussed.
Romijn
J A
JA
Department of Intensive Care, University of Amsterdam, The Netherlands.
Godfried
M H
MH
Wortel
C
C
Sauerwein
H P
HP
D000328:Adult; D016207:Cytokines / Q000097:blood*; D006728:Hormones / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008589:Meningococcal Infections / Q000097:blood* / Q000150:complications; D018805:Sepsis / Q000097:blood* / Q000150:complications; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D006728:Hormones; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha