Interleukin-1 and -2 in sera of patients with chronic hepatitis (type B).
IL-1 beta and IL-2 values in serum from 28 patients with chronic hepatitis B diagnosed by liver biopsy and 23 healthy controls were measured by the radioimmunoassay (RIA) method. Though both values in patients seropositive for anti-HBe were slightly higher than those in patients seropositive for HBeAg, the differences between the two groups were not statistically significant. In contrast, the relationship between IL-1 beta and IL-2 in patients with chronic hepatitis was statistically significant (P less than 0.001). In general, high values of serum IL-1 beta and IL-2 were seen in patients with chronic persistent hepatitis and low values of serum IL-1 beta and IL-2 were seen in patients with chronic active hepatitis (severe) and in some of these with chronic persistent hepatitis. Serum IL-1 beta and IL-2 values of all patients with chronic hepatitis were higher than in healthy controls (P less than 0.001). Serum IL-1 beta and IL-2 in chronic hepatitis (B) are important indicators of the grade of the inflammatory state of the liver.
Ozeki
T
T
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Imanishi
K
K
Unoki
H
H
Funakoshi
K
K
Kiya
Y
Y
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000097:blood*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007375:Interleukin-1; D007376:Interleukin-2