Impregnation of polytetrafluoethylene (PTFE) vascular grafts with C-14-forskolin, a new concept in surface treatment of grafts.
Ten prosthetic polytetrafluoroethylene grafts (50 mm length, i.d. 4 mm) were surface treated with a 0.01% C-14-forskolin solution prior to interposition in the femoral arteries of 5 Australian sheep. The following parameters were monitored: femoral artery blood flow, platelet aggregation, C-14 blood and graft activity measured at intervals up to 120 minutes after declamping (DC). There was only a slightly decreased platelet aggregation in arterial blood samples 30 min. after DC and no changes in blood flow. After an initial peak C-14-forskolin graft activity declined rapidly during the first 30 minutes, thereafter only very slowly. C-14-forskolin blood activity also showed an initial peak and thereafter a fairly steady level 20-120 minutes after DC. These results are discussed in relation to previously very encouraging results in improving graft patency using an identical protocol of graft treatment with forskolin.
Christenson
J T
JT
Department of Surgery, Faculty of Medicine, Kuwait University, Safat.
Thulesius
O
O
Nazzal
M
M
D000818:Animals; D001807:Blood Vessel Prosthesis; D005576:Colforsin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D012756:Sheep
D010975:Platelet Aggregation Inhibitors; D005576:Colforsin; D011138:Polytetrafluoroethylene