[Effect of some GABA, glycine, or glutamic acid derivatives on the forced swimming test in mice].
Three GABA derivatives, the GABA-steatamide (GS), the GABA-linoleamide (GL) and the progabide, two glycine derivatives, the glycine-steatamide (SG) and the glycine-linoleamide (LG) and, lastly, a glutamic acid derivative, the glutamic acid palmitamide (PGt), were studied in the forced swimming test (Porsolt's test) on mice. The anti-immobility effect, referring to the existence of antidepressive properties, was significant for the SG, LG, GL and PGt. It seems that the relative intensity of the anti-immobility effect on the one hand and the sedative properties on the other, could operate on the experimental profile of these derivatives in the Porsolt's test.
Vamvakidès
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A
Laboratoire Chropi, Paris.
D000818:Animals; D005971:Glutamates / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009483:Neuropsychological Tests; D005082:Physical Exertion / Q000187:drug effects*; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D005998:Glycine
Effet de quelques dérivés du GABA, de la glycine ou de l'acide glutamique sur le test de la nage forcée chez la Souris.