title: Inner ear impairment following combined CDDP (platinum preparation) and radiation therapy.
abstract: Hearing ability was examined in patients with head and neck cancer treated by combined CDDP and electron beam therapy. In 3 of 7 patients with maxillary cancer, hearing impairment apparently attributable to the therapy was noted on the affected side. In one of these 3 patients, the temporal bone was observed, but the cause of hearing impairment could not be determined. We present patients with cancer of the external ear in whom radiation-caused hearing impairment worsened probably due to combined CDDP and electron beam therapy.
authors.affiliation: Department of Otolaryngology, Fukushima Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Anzai
authors.forename: I
authors.initials: I
authors.lastname: Ohtani
authors.forename: T
authors.initials: T
authors.lastname: Hoshino
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D007758:Ear, Inner / Q000187:drug effects; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D011878:Radiotherapy / Q000009:adverse effects*; D013701:Temporal Bone / Q000473:pathology
chemical_list: D009944:Organoplatinum Compounds; C055423:didimethylsulfoxide dichloroplatinum(II)