GM1 ganglioside reduces edema and monoaminergic neuronal changes following experimental focal ischemia in rat brain.
Seventy-two hours following a middle cerebral artery occlusion, the associated increase in water content on the ischemic side was significantly reduced by the exogenous administration of monosialoganglioside GM1 (30 mg/kg, i.p.). The levels of dopamine and serotonin on the ischemic side were approximately 50% and 80% of those on the contralateral non-ischemic side, respectively. Treatment with GM1 (5 times during the first 48 h after occlusion) produced a significant reduction in the levels of dopamine and serotonin loss. The present findings are compatible with the observed protective action of the exogenously administered GM1 following ischemic brain injury.
Koga
T
T
Institute of Brain Diseases, Kurume University School of Medicine, Japan.
Kojima
H
H
Yamada
S
S
Miki
K
K
Nishi
S
S
Inanaga
K
K
Shoji
H
H
Kaji
M
M
Jonsson
G
G
Toffano
G
G
D000818:Animals; D001834:Body Water / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000627:therapeutic use*; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D005677:G(M1) Ganglioside; D004298:Dopamine