title: Future prospects for the chemotherapy of human trypanosomiasis. 2. Combination chemotherapy and African trypanosomiasis.
abstract: This paper reviews the progress which has been achieved with combination chemotherapy of experimental murine central nervous system trypanosomiasis. Successful treatments have been achieved with suramin followed by 5-nitroimidazoles; difluoromethylornithine in combination with bleomycin, 9-deazainosine, suramin, arsenicals, antimonials and diamidines; and also the arsenicals in combination with the 5-nitroimidazoles or nifurtimox. Pretreatment with prednisolone and azathioprine, to minimize reactive encephalopathies, and supportive treatment with oxygen are both indicated.
authors.affiliation: Department of Veterinary Parasitology, University of Glasgow, UK.
authors.forename: F W
authors.initials: FW
authors.lastname: Jennings
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005544:Forecasting; D006801:Humans; D008590:Meningoencephalitis / Q000188:drug therapy; D051379:Mice; D009593:Nitroimidazoles / Q000627:therapeutic use; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
chemical_list: D009593:Nitroimidazoles; C052587:4-nitroimidazole