title: Human metallothionein genes: structure of the functional locus at 16q13.
abstract: The functional human metallothionein (MT) genes are located on chromosome 16q13. We have physically mapped the functional human MT locus by isolation and restriction digest mapping of cloned DNA. The mapped region contains all sequences on chromosome 16 that hybridize to metallothionein gene probes and comprises 14 tightly linked MT genes, 6 of which have not been previously described. This analysis defines the genetic limits of metallothionein functional diversity in the human genome.
authors.affiliation: Department of Biochemistry, University of Tasmania, Australia.
authors.forename: A K
authors.initials: AK
authors.lastname: West
authors.forename: R
authors.initials: R
authors.lastname: Stallings
authors.forename: C E
authors.initials: CE
authors.lastname: Hildebrand
authors.forename: R
authors.initials: R
authors.lastname: Chiu
authors.forename: M
authors.initials: M
authors.lastname: Karin
authors.forename: R I
authors.initials: RI
authors.lastname: Richards
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D005796:Genes; D006801:Humans; D008668:Metallothionein / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D011544:Pseudogenes
chemical_list: D008668:Metallothionein