Regulation of respiratory activity of brown adipose tissue mitochondria through changes in cytochromes.
Exposure of cold-acclimatized rats to heat (37 degrees C) for a short period decreased brown adipose tissue (BAT) mitochondrial substrate-dependent oxygen uptake and H2O2 generation. Both the concentration and substrate-dependent rate of cytochrome b reduction decreased as early as 3 h of heat exposure. These results identify cytochrome b as the locus of regulation of electron transport in BAT mitochondria under conditions of heat stress.
Gaikwad
A
A
Department of Biochemistry, Indian Institute of Science, Bangalore.
Ramasarma
T
T
Kurup
C K
CK
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D003580:Cytochromes / Q000378:metabolism*; D004579:Electron Transport / Q000502:physiology; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003580:Cytochromes; D006861:Hydrogen Peroxide