[Gougerot-Sjögren syndrome associated with dysthyroidism].
The occurrence of Gougerot-Sjögren syndrome in a context of dysthyroidism is not a chance happening, as is reflected by the 37% rate of incidence. Routine labial biopsy, carried out in 59 cases of primary hypothyroidism due to atrophic thyroiditis, 20 of Basedow's disease and 4 of Hashimoto thyroiditis identified Gougerot-Sjögren syndrome (3-4 Chisholm grade) in 3 of the 59 cases of hypothyroidism i.e. in 5 percent, and in one Basedow case out of 20, i.e. 5 percent. Using Kaplan's criteria, the incidence of Gougerot-Sjögren syndrome rises to 22 percent in hypothyroidism and 30 percent in Basedow's disease. Consequently, the incidence of Gougerot-Sjögren syndrome is higher in Basedow disease than in primary hypothyroidism. Gougerot-Sjögren syndrome is seen particularly in dysthyroidism involving manifest and all-round clinical signs. This association does not seem to result from one disease being caused by the other, but the outcome of the onset of entities to which a genetically determined context predisposes the subject, as is shown by the prevalence of HLA DRW3 and HLA B8 groupings in Gougerot-Sjögren syndrome, in primary hypothyroidism, in Basedow's disease and in Hashimoto's thyroiditis.
Kolsi
R
R
Service de Médecine Interne et de Rhumatologie, Centre Hospitalier Universitaire, Sfax.
Abid
M
M
Rebai
T
T
Sellami
F
F
Bahloul
Z
Z
Hachicha
J
J
Rekik
N
N
Jarraya
A
A
D000328:Adult; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000276:immunology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology; D013959:Thyroid Diseases / Q000150:complications* / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology
Syndrome de Gougerot-Sjögren associé aux dysthyroïdies.