title: [Action of the antihypertensive effect of captopril on manifestations of hypertrophy and several parameters of myocardial metabolism].
abstract: The administration of captopril (CP, 30 mg/kg) limited the arterial hypertension induced by the coarctation of the renal arteria and cardiac hypertrophy in rats. CP prevented the activation of MB-KK and glucoso-6-phosphate dehydrogenase. Besides CP decreased the activity of pyruvate kinase and increased that of malate dehydrogenase. These data demonstrate, that CP prevents both the cardiac hypertrophy and metabolic changes in animals with the renal hypertension.
authors.forename: R
authors.initials: R
authors.lastname: Kolarova
authors.forename: O
authors.initials: O
authors.lastname: Petkov
mesh_terms: D000818:Animals; D002216:Captopril / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000517:prevention & control*; D003402:Creatine Kinase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006977:Hypertension, Renal / Q000188:drug therapy*; D007527:Isoenzymes; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007527:Isoenzymes; D002216:Captopril; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D011770:Pyruvate Kinase; D003402:Creatine Kinase
vernacular_title: Vliianie antigipertenzivnogo éffekta kaptoprila na vyrazhennost' gipertrofii i nekotorye parametry metabolizma serdechnoĭ myshtsy.