Inhibition of nociceptive responses of wide-dynamic-range neurons by peripheral nerve stimulation.
Of 107 neurons from the sacral and coccygeal levels of the spinal cord in anesthetized intact rats examined, 62 wide-dynamic-range (WDR) neurons that responded to noxious heating of the tail were recorded. On the basis of their inhibitory responses through A-beta or A-delta afferent fibers to noxious stimulation, these neurons were classified into one of the following three types: Type I--neurons inhibited only by A-beta afferent nerve impulses; Type II--neurons inhibited only by A-delta afferent nerve impulses; Type III--neurons inhibited by both. The present results are compared with previously reported behavioral results.
Tsuruoka
M
M
Department of Physiology, Showa University School of Dentistry, Tokyo, Japan.
Li
Q J
QJ
Matsui
A
A
Matsui
Y
Y
D000818:Animals; D004558:Electric Stimulation; D005260:Female; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology