Effects of ethanol ingestion and urinary acidity on the metabolism of triethylamine in man.
In four volunteers exposed to triethylamine (TEA) by inhalation (20 mg/m3, 8 h), the nonrenal clearance of TEA into triethylamine-N-oxide (TEAO) was inhibited by 15 to 30% by intake of ethanol (blood serum level in average 25 mmol/l). Ethanol intake caused a decrease of plasma levels of TEA and TEAO, and of the fractional formation of TEAO. This may partly be due to a second effect of ethanol; it caused a slight decrease of urinary pH, which led to an increase of the urinary TEA excretion rate, with a possible withdrawal of TEA from oxygenation. Indeed, this effect was efficiently counteracted by intake of sodium bicarbonate, which caused a decrease of renal clearance of TEA, and increases of plasma levels of TEA and TEAO, and of the fractional formation of TEAO. A change of urinary pH by about two units caused a change of renal clearance of TEA by a factor of three and of the oxygenation by two. The renal clearance of TEAO was not affected by urinary pH.
Akesson
B
B
Department of Occupational Medicine, University Hospital, Lund, Sweden.
Skerfving
S
S
D000395:Air Pollutants, Occupational / Q000032:analysis; D000428:Alcohol Drinking / Q000502:physiology*; D001944:Breath Tests; D004347:Drug Interactions; D005021:Ethylamines / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged
D000395:Air Pollutants, Occupational; D005021:Ethylamines; C016162:triethylamine