C-reactive protein and 6-keto prostaglandin F 1-alpha in patients with gynecologic cancer.
C-reactive protein (CRP) is an acute phase reactant that appears to have a variety of biologic effects, including stimulation of prostaglandin production by peripheral blood monocytes. Both CRP and 6-keto prostaglandin F 1-alpha (6-keto PGF1-alpha) have been noted to be elevated in the sera of patients with malignant disease, therefore the current study was undertaken to determine whether any correlation exists between serum levels of these two substances. Thirty-five samples of sera from 16 patients undergoing treatment for primary gynecologic malignancies were tested. CRP was elevated above normal in 97% of samples and 6-keto PGF1-alpha was elevated in 91% of samples. No correlation between levels of CRP and 6-keto PGF1-alpha was identified. Serial serum samples were available for 6 patients undergoing therapy; in 5 of 6 patients CRP levels reflected the clinical disease course. There was no apparent correlation between 6-keto PGF1-alpha levels and clinical progression or regression of disease.
Terada
K
K
Department of Obstetrics and Gynecology, University of Hawaii, School of Medicine, Honolulu 96826.
Hayashi
G
G
Hokama
Y
Y
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000628:therapy; D006801:Humans
D015121:6-Ketoprostaglandin F1 alpha; D002097:C-Reactive Protein