title: Transference of hepatic coma to normal rats from galactosamine treated donors by reverse plasma exchange.
abstract: It was possible by exchange transfusion to induce the same grade of hepatic coma in normal recipients as had occurred in donors which had previously been treated with D(+) galactosamine hydrochloride (HCl). The exchange transfusion was carried out by carotid arterial and jugular venous cannulation in conscious and unrestrained recipient rats. Thus, the coma inducing compounds generated as a consequence of acute hepatic failure, appear to circulate in the plasma for a considerable time after galactosamine-HCl is cleared and these substances are able to affect the nervous system in the presence of an intact and functioning normal liver.
authors.affiliation: Department of Surgery, Royal postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Ryan
authors.forename: M
authors.initials: M
authors.lastname: Aslam
authors.forename: J M
authors.initials: JM
authors.lastname: Courtney
mesh_terms: D000818:Animals; D005260:Female; D005688:Galactosamine; D006501:Hepatic Encephalopathy / Q000097:blood / Q000209:etiology*; D010951:Plasma Exchange; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005688:Galactosamine