title: Synthesis and pharmacological properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines.
abstract: The synthesis and properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines (7a--g) were described. New compounds were studied in rats and in mice in the tests used for preclinical assessment of antidepressant or anxiolytic activity. Compound 7c showed weak antagonism towards the reserpine-induced hypothermia and shortened immobility time in the despair test. None of the tested compounds had an anxiety-relieving action.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
authors.forename: P
authors.initials: P
authors.lastname: Nantka-Namirski
authors.forename: A
authors.initials: A
authors.lastname: Dereń
authors.forename: E
authors.initials: E
authors.lastname: Chojnacka-Wójcik
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000633:toxicity; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced / Q000188:drug therapy; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000633:toxicity
chemical_list: D001381:Azepines; D009281:Naphthalenes; D011725:Pyridines; D012110:Reserpine; D001058:Apomorphine