[Construction and application of atropine flow-through sensor in flow injection analysis].
A new kind of flow-through sensor for atropine has been studied. It exhibits Nernstian response for atropine with a slope of 54 +/- 1 mV/decade over the concentration range of 0.02-200 mmol/L at pH 5-8. The sensitivity coefficients of common compounds were determined. Only bromo-geramine, clonidine, strychnine and amantadine showed remarkable interference. Direct potentiometry for determination of atropine showed an average recovery of 99.2% and a relative standard deviation of 1.3%. It has been used in flow injection analysis (FIA) of atropine, anisodamine and scopolamine and belladonna preparations. Rate of analysis of as high as 60-100 samples/h was achieved.
Liu
W Z
WZ
Hubei Provincial Institute for Drug Control, Wuhan.
Wu
P Z
PZ
Yan
Z
Z
Yang
C H
CH
Li
A J
AJ
Xu
R Z
RZ
D001532:Atropa belladonna / Q000032:analysis; D001285:Atropine / Q000032:analysis*; D008722:Methods; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012601:Scopolamine / Q000032:analysis; D012991:Solanaceous Alkaloids / Q000032:analysis; D014665:Vasodilator Agents / Q000032:analysis
D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D001285:Atropine; D012601:Scopolamine