Plasma catecholamines and their physiologic thresholds during the first ten days of life in sheep.
We studied serial plasma catecholamine levels in healthy newborn sheep over the first ten days of life. The results show that plasma norepinephrine values in newborn sheep are 3-4 fold higher, and plasma epinephrine values are two-fold higher than values in term fetal sheep. These elevations are sustained over the first 10 days of life. Cardiovascular (heart rate and blood pressure) and metabolic parameters (glucose and free fatty acids) are also significantly elevated above fetal levels. We performed graded catecholamine infusions in newborn animals and adult ewes to determine the minimum plasma catecholamine concentrations necessary for discernible physiologic effects. In response to step-wise increases in epinephrine or norepinephrine infusion rates, there were immediate increases in blood pressure and other physiologic responses. This pattern was seen in both newborn and adult animals, and differed from previous observations in fetal sheep where log-linear, dose response curves characteristic of a threshold response were seen. These results suggest that during the first two weeks of life plasma catecholamine levels are elevated above the threshold value for physiologic responses. These sustained elevations in circulating catecholamines are important in the maintenance of physiologic homeostasis.
Martinez
A M
AM
Perinatal Research Laboratories, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90509.
Padbury
J F
JF
Humme
J A
JA
Evans
C W
CW
Shames
L
L
D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006339:Heart Rate; D006400:Hematocrit / Q000662:veterinary; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous / Q000662:veterinary; D009638:Norepinephrine / Q000008:administration & dosage / Q000097:blood*; D010100:Oxygen / Q000097:blood; D011897:Random Allocation; D012016:Reference Values; D012756:Sheep / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010100:Oxygen; D009638:Norepinephrine; D004837:Epinephrine