title: [High-degree obesity--a risk factor for the development of diabetes mellitus].
abstract: In high degree obesity there a significantly smaller area under the curve of C-peptide after stimulation with Tolbutamide and significantly lower insulin sensitivity measured in vivo by euglycemic hyperinsulinemic clamp-technique (Biostator) than in moderate obesity. This allows the conclusion that high degree obesity is a risk factor for the development of diabetes mellitus.
authors.forename: A M
authors.initials: AM
authors.lastname: Borisova
authors.forename: D
authors.initials: D
authors.lastname: Koev
authors.forename: G
authors.initials: G
authors.lastname: Kirilov
mesh_terms: D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009765:Obesity; D012307:Risk Factors; D014044:Tolbutamide
chemical_list: D002096:C-Peptide; D007328:Insulin; D014044:Tolbutamide
vernacular_title: Visokostepennoto zatlŭstiavane--riskov faktor za razvitie na zakharna bolest.