title: Prostaglandin E1 bladder instillations to control severe hemorrhagic cystitis.
abstract: Severe hemorrhagic cystitis developed in 6 children after marrow transplantation, 3 of whom had a viral etiology. All 6 patients received instillations of prostaglandin E1 directly into the bladder and 5 of the 6 had complete resolution of hematuria. This finding contrasts with our previous experience with severe hemorrhagic cystitis, particularly the type due to a viral infection, persisting in the face of numerous bladder manipulations. We encourage the use of this nontoxic treatment to gain further information regarding its effect on the bladder epithelium. The mechanism of action remains completely unknown.
authors.affiliation: Division of Pediatric Nursing, University of Iowa, Iowa City.
authors.forename: M E
authors.initials: ME
authors.lastname: Trigg
authors.forename: J
authors.initials: J
authors.lastname: O'Reilly
authors.forename: S
authors.initials: S
authors.lastname: Rumelhart
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: M
authors.initials: M
authors.lastname: Holida
authors.forename: P
authors.initials: P
authors.lastname: de Alarcon
mesh_terms: D000283:Administration, Intravesical; D000293:Adolescent; D000527:Alprostadil / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans
chemical_list: D000527:Alprostadil