title: Dense intramembranous deposit disease: a clinical comparison of histological subtypes.
abstract: The accumulation of osmiophilic dense deposits in glomerular mesangial and basement membranes (dense intramembranous deposit disease, or DIDD) is associated with variable histologic alterations of the kidneys. We compared clinical features and long-term renal outcome in 21 patients representing two histologic subtypes of DIDD, namely membranoproliferative glomerulonephritis (MPGN) and focal segmental glomerulonephritis (FSGN). We found that MPGN-type DIDD in 12 patients was associated with nephrotic syndrome in 12, persistent hypocomplementemia in 10 and progression to chronic renal insufficiency in 8. In 9 patients with the focal segmental variety of DIDD, nephrotic syndrome was observed in 3, persistent hypocomplementemia in none, and progression to renal insufficiency in 2 (significance: nephrotic syndrome, p = 0.001; persistent hypocomplementemia, p = 0.0001; chronic renal insufficiency, p = 0.02). In one patient transition from focal segmental to MPGN-type DIDD was observed. We conclude that DIDD is a heterogeneous disorder, and that certain clinical and histologic features may be useful in predicting ultimate outcome.
authors.affiliation: Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: C E
authors.initials: CE
authors.lastname: Kashtan
authors.forename: B
authors.initials: B
authors.lastname: Burke
authors.forename: G
authors.initials: G
authors.lastname: Burch
authors.forename: S
authors.initials: S
authors.lastname: Gustav Fisker
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003176:Complement C3 / Q000172:deficiency; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology; D013997:Time Factors
chemical_list: D003176:Complement C3