title: Acyclovir pharmacokinetics in plasmapheresis.
abstract: During experimental treatment of human immunodeficiency virus (HIV-1) infection using high doses of acyclovir (ACV) (600 mg IV every 8 h), cyclosporin, and several courses of plasmapheresis (PE) (60 ml/kg), ACV pharmacokinetics in three patients have been measured. The results with or without PE were not significantly different: half-time of elimination 3 vs. 2.3 h, volume of distribution 1.8 vs. 1.14 liter/kg, and total clearance 404 vs. 314 ml/min. The clearance and the fraction of elimination due to PE were 5.27 ml/min and 2.5%, respectively. These findings suggest that supplemental doses of ACV are not needed when plasmapheresis is performed.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hopital du Bocage, Dijon, France.
authors.forename: P Y
authors.initials: PY
authors.lastname: Chavanet
authors.forename: F
authors.initials: F
authors.lastname: Bailly
authors.forename: C
authors.initials: C
authors.lastname: Mousson
authors.forename: A
authors.initials: A
authors.lastname: Waldner-Combernoux
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
authors.forename: J M
authors.initials: JM
authors.lastname: Rebibou
authors.forename: J M
authors.initials: JM
authors.lastname: Chalopin
authors.forename: H
authors.initials: H
authors.lastname: Portier
mesh_terms: D000212:Acyclovir / Q000493:pharmacokinetics*; D000328:Adult; D006207:Half-Life; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010956:Plasmapheresis
chemical_list: D000212:Acyclovir