title: Effects of some adenosine analogs on morphine-induced analgesia and tolerance.
abstract: 1. The analogs of adenosine D- and L-phenylisopropyladenosine (D- and L-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, D- and L-PIA did not affect the process.
authors.affiliation: Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.
authors.forename: E
authors.initials: E
authors.lastname: Contreras
authors.forename: A
authors.initials: A
authors.lastname: Germany
authors.forename: M
authors.initials: M
authors.lastname: Villar
mesh_terms: D015762:2-Chloroadenosine / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D004357:Drug Synergism; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010660:Phenylisopropyladenosine / Q000494:pharmacology
chemical_list: D000700:Analgesics; D015762:2-Chloroadenosine; D010660:Phenylisopropyladenosine; D009270:Naloxone; D002110:Caffeine; D009020:Morphine; D000241:Adenosine