Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient.
A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.
Griffith
R C
RC
Department of Pathology, Miriam Hospital, Brown University, Providence, Rhode Island 02906.
Saha
B K
BK
Janney
C M
CM
Ratner
L
L
Brunt
E M
EM
Gajl-Peczalska
K J
KJ
Hanto
D W
DW
D000328:Adult; D015329:Gene Rearrangement, T-Lymphocyte; D005838:Genotype; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology