[Animal experiment model of the effect of ultraviolet irradiation on hexachlorobenzene-induced porphyria].
The Effect of UV-Irradiation on the Hexachlorobenzene-induced Porphyria in an Experimental Animal Model Hexachlorobenzene is able to induce in humans and different animal species a hepatic porphyria, which is comparable to porphyria cutanea tarda. We studied whether hexachlorobenzene feeding could induce this porphyria also in hairless rats (Rowett-Nude), as these are suitable for photobiologic studies. After development of hepatic porphyria the rats were irradiated either with UV-A or UV-B light. Biochemical effects on the porphyrin metabolism and clinical as well as histologic skin changes were examined. In the liver of the porphyric rats, UV-A and UV-B irradiation induced increased aminolevulinic acid synthase activity accompanied with augmentation of hepatic porphyrin content. UV-A or UV-B irradiation also lead to increased total porphyrin contents in the skin of porphyric compared to non-irradiated animals. Clinically and histologically, however, only UV-A irradiation induced lesions, which were comparable to skin manifestations of porphyria cutanea tarda.
Lehmann
P
P
Hautklinik Heinrich-Heine-Universität Düsseldorf.
Schäfer
T
T
Bolsen
K
K
Goerz
G
G
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006581:Hexachlorobenzene / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000532:radiotherapy*; D011164:Porphyrias / Q000139:chemically induced / Q000532:radiotherapy*; D011166:Porphyrins / Q000097:blood; D051381:Rats; D011923:Rats, Nude; D012871:Skin Diseases / Q000139:chemically induced / Q000532:radiotherapy*; D014467:Ultraviolet Therapy
D011166:Porphyrins; D006581:Hexachlorobenzene
Tierexperimentelles Modell zur Wirkung von UV-Bestrahlungen auf die Hexachlorobenzol-induzierte Porphyrie.