Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis--Dutch type.
Hereditary cerebral hermorrhage with amyloidosis--Dutch type, one of the 'cerebral beta-amyloid diseases', like Alzheimer's disease, is characterized by extensive deposition of amyloid in small cerebral vessels. We investigated the presence of parenchymal beta-protein deposits in two Dutch patients with hereditary cerebral hemorrhage with amyloidosis. Immunostaining with anti-SP28 revealed a full spectrum of these deposits, varying from preamyloid deposits to burned-out plaques. However, their density is less than in Alzheimer's disease, and immunostaining with Alz50 and anti-PHF did not show abnormal neurites in and around amyloid deposits in these two patients.
Timmers
W F
WF
Department of Pathology, New York University Medical Center, NY 10016.
Tagliavini
F
F
Haan
J
J
Frangione
B
B
D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000686:Amyloidosis / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D016229:Amyloid beta-Peptides