title: Utilization of a two-channel, microprocessor-based EEG device for monitoring cognitively vulnerable patients.
abstract: Several experiments were conducted to validate the use of a two-channel microprocessor-based electroencephalographic (EEG) device for detecting changes in EEG background rhythm in the clinic or at the bedside. The reliability of background measures in healthy individuals was evaluated by obtaining EEG data on 20 control subjects on two occasions separated by at least 1 day. The sensitivity to an experimental toxic encephalopathy was evaluated using measures of EEG and the Buschke Memory Selective Reminding Test after the administration of scopolamine hydrobromide, 0.86 mg subcutaneously, to three healthy volunteers. Postdrug measures of the EEG showed significant group differences from controls at 1 and 2 hours for relative alpha and relative theta power. The drug-induced change for each individual exceeded the predicted range calculated from data on control subjects. These findings suggest the feasibility and the potential utility of this method. This approach was extended to the elderly with measures on 102 subjects (average age, 85 years) living in an institutional setting. EEG measures in the population were of acceptable reliability and were significantly correlated with Mini-Mental State Examination (MMSE) scores (r = -.375 for theta and .357 for beta). Preliminary findings suggest that this method may detect metabolic encephalopathies in the elderly. The study demonstrates the potential value of this approach and suggests the need for further research.
authors.affiliation: Department of Psychiatry, Medical College of Pennsylvania/EPPI, Philadelphia 19129.
authors.forename: I R
authors.initials: IR
authors.lastname: Katz
authors.forename: N M
authors.initials: NM
authors.lastname: Sussman
authors.forename: J
authors.initials: J
authors.lastname: Mossey
authors.forename: L
authors.initials: L
authors.lastname: Muenz
authors.forename: R N
authors.initials: RN
authors.lastname: Harner
authors.forename: V
authors.initials: V
authors.lastname: Jethanandani
mesh_terms: D000367:Age Factors; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation* / Q000706:statistics & numerical data; D006801:Humans; D008568:Memory / Q000187:drug effects; D008838:Microcomputers; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012601:Scopolamine / Q000494:pharmacology; D012680:Sensitivity and Specificity
chemical_list: D012601:Scopolamine