Chiral high performance liquid chromatography of drug molecules.
The individual enantiomers of racemic drugs frequently differ in their biological effects. For pharmacological studies of such drugs there is therefore a need for an effective means of separating and quantifying the enantiomers in biological samples. As their physicochemical properties are similar, the assay of enantiomers is generally regarded as difficult, time-consuming and error-prone. However, recent developments in high performance liquid chromatography (HPLC) chiral stationary phase technology overcome some of these problems and provide a more efficient and reliable way of assaying enantiomeric drugs.
Mehta
A C
AC
Department of Pharmacy, General Infirmary, Leeds, Yorkshire, U.K.
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations