[The dynamics of the griseofulvin levels in the blood and skin of guinea pigs during its combined use with alpha-tocopherol].
Experiments with 120 guinea pigs have revealed that skin griseofulvin levels depend on blood griseofulvin level and reduce after a prolonged (for 3-4 weeks) administration of the antibiotic in a dose of 30 mg/kg. Reduction of P-450 system enzymes activities achieved with alpha-tocopherol slows down griseofulvin biotransformation rate and significantly elevates its blood serum and skin concentrations.
Lashmanova
A P
AP
Omel'chenko
O G
OG
Akimov
V G
VG
D000818:Animals; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006118:Griseofulvin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D013535:Suspensions; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*
D013535:Suspensions; D014810:Vitamin E; D006118:Griseofulvin
Dinamika soderzhaniia grizeoful'vina v krovi i kozhe morskikh svinok pri ego kompleksnom primenenii s al'fa-tokoferolom.