title: Effect of nonadrenergic noncholinergic inhibitory nerve stimulation on the allergic reaction in cat airways.
abstract: To examine the effect of nonadrenergic noncholinergic (NANC) inhibitory nerve stimulation on the antigen inhalation with allergic animals, changes in pulmonary resistance (RL) and arterial plasma histamine concentration ([H]) caused by inhalation of Ascaris suum antigen were studied in five control (Group A) and five nerve-stimulated (Group B) cats, which were anesthetized and mechanically ventilated. All animals were actively sensitized with Ascaris antigen before the experiment. After cholinergic and beta-adrenergic blockade with intravenously administered atropine (3 mg/kg) and propranolol (2 mg/kg), inhalation of the antigen (1:100 dilution) was performed for 3 min. For Group B, bilateral cervical vagi were stimulated electrically for 1 min before the antigen inhalation and successively every 30 s until 5 min had passed from the onset of inhalation. RL and [H] were determined before, during, and after antigen inhalation in both groups. Baseline RL and [H] did not differ significantly between groups (16.3 +/- 2.2 (mean +/- SE) cm H2O/L/s and 14.0 +/- 0.7 ng/ml, respectively, for Group A; 14.4 +/- 1.3 and 15.6 +/- 2.7, respectively, for Group B). Increases in RL and [H] of Group B after the antigen inhalation were significantly depressed, compared with Group A (p less than 0.01 and p less than 0.05, respectively, two-way ANOVA). The increase in RL 5 min after antigen inhalation was 113 +/- 19% for Group A and 28 +/- 8% for Group B, and the increase in [H] at the same point was 36.3 +/- 9.1 ng/ml for Group A and 4.4 +/- 1.4 ng/ml for Group B.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Ichinose
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: U
authors.initials: U
authors.lastname: Katsumata
authors.forename: T
authors.initials: T
authors.lastname: Takishima
mesh_terms: D000403:Airway Resistance; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D001200:Ascaris / Q000276:immunology; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000294:innervation* / Q000503:physiopathology; D002415:Cats; D004558:Electric Stimulation; D006632:Histamine / Q000097:blood; D007114:Immunization; D009433:Neural Inhibition; D011433:Propranolol / Q000494:pharmacology; D012130:Respiratory Hypersensitivity / Q000097:blood / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D000941:Antigens; D001285:Atropine; D006632:Histamine; D011433:Propranolol