Autoantibodies against triosephosphate isomerase. A possible clue to pathogenesis of hemolytic anemia in infectious mononucleosis.
In sera from patients with acute EBV, infection and the clinical symptoms of infectious mononucleosis antibodies of the Ig class M were found that are directed against two cellular proteins. The molecular mass of these proteins was determined to be 29 (p29) and 26 kD (p26), respectively, in SDS-PAGE. P29 was identified as part of the glycolytic enzyme triosephosphate isomerase (TPI) by comparison of the NH2-terminal amino acid sequences. A purified antibody against TPI induces a 51Cr release from human erythrocytes. Possibly, anti-TPI causes hemolysis, which is an infrequent but serious symptom of infectious mononucleosis.
Ritter
K
K
Department of Medical Microbiology, University of Göttingen, Federal Republic of Germany.
Brestrich
H
H
Nellen
B
B
Kratzin
H
H
Eiffert
H
H
Thomssen
R
R
D000595:Amino Acid Sequence; D000743:Anemia, Hemolytic / Q000150:complications / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002238:Carbohydrate Epimerases / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008969:Molecular Sequence Data; D011817:Rabbits; D014305:Triose-Phosphate Isomerase / Q000276:immunology*
D001323:Autoantibodies; D002238:Carbohydrate Epimerases; D014305:Triose-Phosphate Isomerase