A hydrophilic plasma polymerized film composite with potential application as an interface for biomaterials.
A hydrophilic polymer composite film (approx. 420 nm thick), with potential application as an interface for biomaterials has been prepared on nonorganic substrates, which include glass, silicon, and aluminum foil, using a glow discharge plasma polymerization technique. A thin film (110 nm thick) polymerized from hexane provided an adherent protective coating for the substrate material, and covalent bonding sites for the outer layer polymerized from N-vinyl-2-pyrrolidone. This outer layer provided the hydrophilic surface or interface. The two layers were copolymerized for a short period during transition between monomers to provide an intimate covalently bonded diffuse interphase. Preliminary in vitro and in vivo biocompatibility studies indicate that the hydrophilic film is non-cytotoxic, and does not increase the inflammatory response when compared with negative controls.
Marchant
R E
RE
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
Johnson
S D
SD
Schneider
B H
BH
Agger
M P
MP
Anderson
J M
JM
D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D006586:Hexanes; D008422:Materials Testing; D011108:Polymers; D011205:Povidone; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties
D001672:Biocompatible Materials; D006586:Hexanes; D011108:Polymers; D011205:Povidone