title: [The immunomodulating effect of sodium nucleinate in chronic infectious-allergic urticaria].
abstract: Based on clinical, laboratory, bacterial, allergologic and immunologic studies a group of patients with infectious allergic urticaria (IAU) was distinguished. The immunologic examination of 30 patients with IAU identified a decrease in phagocytosis. Sodium nucleinate (SN) was employed as an immunomodulator as compared to placebo. SN was noted to produce an optimal immunomodulating effect, provided it was combined with antibacterial drugs. The use of SN in patients with IAU produced a good clinical effect elucidated for 6 months. It is recommended that SN be used as an immunomodulator in the multimodality therapy of IAU and introduced into the practice of the allergological rooms.
authors.forename: V M
authors.initials: VM
authors.lastname: Zemskov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Poroshina
authors.forename: L V
authors.initials: LV
authors.lastname: Luss
authors.forename: O I
authors.initials: OI
authors.lastname: Belostotskaia
authors.forename: G N
authors.initials: GN
authors.lastname: Mikheeva
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009696:Nucleic Acids / Q000627:therapeutic use*; D012882:Skin Tests; D014581:Urticaria / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; C013683:sodium nucleinate
vernacular_title: Immunomoduliruiushchiĭ éffekt nukleinata natriia pri kronicheskoĭ infektsionno-allergicheskoĭ krapivnitse.