[Acute effects of extracorporeal LDL cholesterol and fibrinogen elimination on blood rheology and microcirculation].
Long-term intermittent heparin-induced extracorporeal low-density lipoprotein (LDL)-cholesterol precipitation was performed in three men - aged 32, 52 and 56 years - with severe familial hypercholesterolaemia and angiographically demonstrated coronary heart disease. This significantly lowered by 65-70% their LDL-cholesterol concentration and by 48-54% their fibrinogen concentration. Fibrinogen elimination reduced plasma viscosity by 13-14% and clearly raised the transcutaneously measured partial pressure of oxygen by 33-50%. Clinically the improved microcirculation achieved a decrease in angina symptoms: the walking distance of the 52-year-old man increased from about 100 m to 4000 m, the daily need of glyceryl trinitrate falling from an average of 12 to 4 aerosol doses.
Kleophas
W
W
Diabetes-Forschungsinstitut, Universität Düsseldorf.
Leschke
M
M
Tschöpe
D
D
Martin
J
J
Schauseil
S
S
Schottenfeld
Y
Y
Strauer
B E
BE
Gries
F A
FA
D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D001809:Blood Viscosity; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000150:complications / Q000628:therapy*; D005340:Fibrinogen / Q000032:analysis*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012212:Rheology
D008078:Cholesterol, LDL; D005340:Fibrinogen; D006493:Heparin; D010100:Oxygen
Akute Wirkungen der extrakorporalen LDL-Cholesterin-und Fibrinogen-Elimination auf Blutrheologie und Mikrozirkulation.