title: Treatment of acute exacerbations of chronic obstructive airways disease--a comparison of amoxycillin and ciprofloxacin.
abstract: Ciprofloxacin and amoxycillin were compared in the treatment of acute exacerbations of chronic obstructive airways disease. One hundred and forty patients were evaluable for overall outcome: 60 patients' sputum specimens yielded positive bacteriological cultures. The predominant pathogens were Haemophilus influenzae (43.3%) and Streptococcus pneumoniae (25.0%). Both regimens were safe and produced few adverse effects. An independent observer judged ciprofloxacin to produce a 91.8% success rate (complete success 21.9%; partial success 69.9%) whilst a 73.1% rate (complete success 10.4%; partial success 62.7%) was seen with amoxycillin.
authors.affiliation: Rotherham District General Hospital, Rotherham, UK.
authors.forename: G S
authors.initials: GS
authors.lastname: Basran
authors.forename: J
authors.initials: J
authors.lastname: Joseph
authors.forename: A M
authors.initials: AM
authors.lastname: Abbas
authors.forename: C
authors.initials: C
authors.lastname: Hughes
authors.forename: G S
authors.initials: GS
authors.lastname: Tillotson
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D016037:Single-Blind Method; D013183:Sputum / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D002939:Ciprofloxacin; D000658:Amoxicillin