title: Localization of mucinous-like carcinoma associated antigen (MCA) in breast pathology: comparison with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA).
abstract: The topographic distribution of a mucinous-like cancer antigen (MCA) recognized by a monoclonal antibody b-12 (MAb b-12) was assessed in benign (38) and malignant (66) breast tissues. The reactivity of MAb b-12 showed a good selectivity for breast tissues, reacting both with normal tissues and breast cancer. The degree of MCA expression was evaluated in the various groups of breast pathology adopting quantitative criteria of assessment. With the criteria of evaluation adopted, strong staining was observed in 71.4% breast carcinomas. The most positive reaction was demonstrated in mucinous carcinoma. MCA distribution in breast tissue was compared with the distribution of two other antigens, CEA and TPA. Reactivity of MAb b-12 was higher than the reactivity shown by the anti-CEA and anti-TPA antibodies.
authors.affiliation: Institute of Pathology, Parma University School of Medicine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Saccani Jotti
authors.forename: M
authors.initials: M
authors.lastname: Fontanesi
authors.forename: A
authors.initials: A
authors.lastname: Colombo
authors.forename: M
authors.initials: M
authors.lastname: Valtolina
authors.forename: A
authors.initials: A
authors.lastname: Tardini
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000378:metabolism*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001941:Breast Diseases / Q000276:immunology / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D019396:Tissue Polypeptide Antigen
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010455:Peptides; D019396:Tissue Polypeptide Antigen; C057387:mucinous carcinoma-associated antigen