Frontal lobes, basal ganglia, temporal lobes--three sites for schizophrenia?
This special issue of the Schizophrenia Bulletin focuses on three brain areas hypothesized to play a role in the etiology of schizophrenia--the frontal lobes, the basal ganglia, and the temporal lobes. Contributors to the issue review evidence from brain-imaging, post-mortem, and psychopharmacological studies that support the involvement of each of these important brain areas in schizophrenia. It is concluded that theories emphasizing cortical/subcortical interconnections rather than a single brain area provide the greatest challenge, and also the greatest promise, to schizophrenia researchers.
Buchsbaum
M S
MS
Dept. of Psychiatry and Human Behavior, University of California, Irvine 92717.
D001479:Basal Ganglia / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000503:physiopathology*