title: [The efficacy of different chemotherapeutic regimens in patients over 50 years old with newly detected destructive tuberculosis of the lungs].
abstract: The outcomes of treatment of 217 patients aged 50 or over with newly diagnosed destructive pulmonary tuberculosis were analysed. Their management included the following 3 regimens: Groups 1 and 2 were on intermittent regimen with drugs introduced parenterally, and Group 3 was on a daily regimen with drugs introduced orally. The intermittent regimens can compete with a daily one, whereas a parenteral administration of all the three drugs (Group 2) can even surpass it in to its efficacy. Cavity closure rate was registered in 74.2, 81.4 and 60.0% in the Groups 1, 2 and 3, respectively. If compared to a daily oral administration, the intermittent one leads to the elimination of destructive changes in the lungs more rapidly and in a shorter period of time. A significant improvement of tolerance to the intermittent drug administration and a decrease in the prescribed medicinal load on the body are noted.
authors.forename: M V
authors.initials: MV
authors.lastname: Musikaeva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
vernacular_title: Effektivnost' razlichnykh skhem khimioterapii bol'nykh starshe 50 let s vpervye vyiavlennym destruktivnym tuberkulezom legkikh.