title: Inotropic activities of imidazopyridines.
abstract: A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.
authors.affiliation: Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Barraclough
authors.forename: J W
authors.initials: JW
authors.lastname: Black
authors.forename: D
authors.initials: D
authors.lastname: Cambridge
authors.forename: V P
authors.initials: VP
authors.lastname: Gerskowitch
authors.forename: R A
authors.initials: RA
authors.lastname: Hull
authors.forename: R
authors.initials: R
authors.lastname: Lyer
authors.forename: W R
authors.initials: WR
authors.lastname: King
authors.forename: C O
authors.initials: CO
authors.lastname: Kneen
authors.forename: M S
authors.initials: MS
authors.lastname: Nobbs
authors.forename: G P
authors.initials: GP
authors.lastname: Shah
mesh_terms: D000758:Anesthesia; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002316:Cardiotonic Agents; D007093:Imidazoles; D011725:Pyridines