title: [T-cell malignant lymphoma with hemophagocytic histiocytosis, hyperferritinemia and disseminated intravascular coagulation syndrome].
abstract: A 57-year-old man was admitted to our hospital with high fever and nasal obstruction. The diagnosis of T cell type malignant lymphoma (T-ML) was made by the biopsy of left nasal cavity tumor. After admission, his general condition was improved by chemotherapy and radiotherapy, but relapsed a month later. He was then treated with chemotherapy, and the partial remission was obtained. During the clinical course, he had a high fever again without any significant infections or exacerbation of T-ML. The data of coagulation system showed DIC. The levels of serum ferritin and LDH were extremely elevated. Bone marrow aspiration showed markedly increased hemophagocytic histiocytes. These data suggested that he was complicated by DIC and hyperferritinemia closely associated with hemophagocytic histiocytosis a part from the underlying T-ML. Causes of DIC and hyperferritinemia associated with hemophagocytic histiocytosis in the present case were discussed.
authors.affiliation: Division of Internal Medicine, Kagoshima City Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Kadokura
authors.forename: K
authors.initials: K
authors.lastname: Shimmyouzu
authors.forename: H
authors.initials: H
authors.lastname: Moritoyo
authors.forename: T
authors.initials: T
authors.lastname: Okadome
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000473:pathology; D005293:Ferritins / Q000097:blood*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D005293:Ferritins