[Facilitation of arginine-vasopressin analogs on learning and memory in rats].
Adult rats were trained in a maze for brightness discrimination (BD) or in a shuttle box for active avoidance. It was found that the pretreatment of 1-desamino-8-D-arginine-vasopressin (DDAVP) enhanced the retention of brightness discrimination and retarted the extinction of avoidance response. Neonatal daily administration for 14 d of both 9-desglycylamide-DDAVP (DGDDAVP) or 2-destyrosyl-3-desphenylalanyl-9-desglycylamide-AVP (AVP4-8), but not D-arginine-AVP4-8 (DAVP4-8) showed significant facilitation on acquisition and subsequent maintenance of BD in adult rats. The results indicate that some of synthetic arginine-vasopressin analogs may directly act on CNS and consequently affect learning behaviors in rats.
Liu
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RY
Shanghai Brain Research Institute, Chinese Academy of Sciences.
Lin
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C
Du
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YC
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects*
D001127:Arginine Vasopressin