Localized unresectable pancreatic cancer.
Treatment results are presented for 40 patients with unresectable localized pancreatic cancer. The treatment protocol consisted of a split-course external radiation therapy to a dose of 50 Gy combined with intravenous 5-fluorouracil on the first 4 days of each course in a dose of 375 mg/m2/day. There was no treatment mortality and morbidity was moderate. Median survival was 9 months. The 3-year survival of six patients and the 5-year survival of three patients are considered significant enough to advise this combined treatment modality as a standard and to use it in comparison with newer treatment schemes in Phase III studies.
Treurniet-Donker
A D
AD
Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
van Mierlo
M J
MJ
van Putten
W L
WL
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000628:therapy*; D011879:Radiotherapy Dosage
D005472:Fluorouracil