[Regulation of immuno- and hematopoiesis with asterin].
It was shown that asterin, a higher plant preparation, had a marked antiblastomic action and a favourable effect on differentiation of the precursor cells and blood cells. It accelerated proliferation, migration of the truncal hemopoietic cells and their transfer from the dormant state into the cellular cycle. It also changed the cell differentiation in the direction of myelopoiesis. The mechanism of the asterin's immunomodulating action was found to be associated with regulation of T-cellular immunity and T-dependent immune response.
Smirnov
V V
VV
Mishenkova
E L
EL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D007136:Immunoglobulins / Q000032:analysis / Q000187:drug effects*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D010456:Peptides, Cyclic; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013154:Spleen / Q000166:cytology
D000972:Antineoplastic Agents, Phytogenic; D007136:Immunoglobulins; D010456:Peptides, Cyclic; D010936:Plant Extracts; C066411:asterin
Reguliatsiia immuno- i gemopoéza asterinom.