[A clinical study of intraarterial infusion therapy with CDDP for primary osteosarcoma].
Eleven patients with primary osteosarcoma were treated by intra-arterial infusion of cisplatin. Cisplatin (50-100 mg/m2) was infused slowly into tumor feeding artery or proximal-to-the-lesion artery. An antidote, sodium thiosulfate, was also administered intravenously in 10 cases and angiotensin II was simultaneously used in 2 cases. Symptoms of heat sensation and local pain were decreased or disappeared in almost all cases and histopathologic changes were observed in 7 cases. No viable tumor cells were seen in 3 cases.
Eiro
I
I
Dept. of Radiology, University Hospital of Kagoshima.
Kobayashi
H
H
Uchiyama
N
N
Itoh
Y
Y
Shinohara
S
S
Itoh
H
H
Morimoto
N
N
Sakoh
T
T
D000293:Adolescent; D000328:Adult; D000804:Angiotensin II / Q000627:therapeutic use; D000931:Antidotes; D001859:Bone Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D012516:Osteosarcoma / Q000098:blood supply / Q000188:drug therapy*; D013885:Thiosulfates / Q000627:therapeutic use
D000931:Antidotes; D013885:Thiosulfates; D000804:Angiotensin II; C017717:sodium thiosulfate; D002945:Cisplatin