The effect of some antiinflammatory drugs on collagen of rat skin.
Collagen content and mutual relationship between type I and type III collagens in the skin of rats chronically treated with some antiinflammatory drugs were evaluated. It was found that prednisone, colchicine, acetylsalicylic acid, indomethacin and phenylbutazone induce a decrease of collagen content in rat skin. In the case of prednisone, acetylsalicylic acid and phenylbutazone modification of type I to type III collagen ratio in rat skin was observed. These observations suggest that non-steroid antiinflammatory drugs may exert similar effects on skin collagen as steroid hormones.
Pałka
J
J
Department of Biochemistry, Academy of Medicine, Białystok, Poland.
Galewska
Z
Z
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003094:Collagen; D010653:Phenylbutazone; D001241:Aspirin; D003078:Colchicine; D011241:Prednisone; D007213:Indomethacin