[Bacterial translocation from the gastrointestinal tract and endogenous infection induced by immunosuppression after burn].
This study described the endogenous infections and bacterial translocation from GI tract caused by immunosuppression after burn. In the group of burned plus injected dexamethasone (DXM) (BIS, n = 31), the rate of enteric bacteria translocation was 67.4%, the rate of visceral abscess was 65.5%, much more higher than in the group of only DXM (IS, n = 15). The translocation of intestinal bacteria also was found in the group of only burned (BU 3/15) and control (ck, 1/23), but endogenous infection did not occur in both group. The bacteria cultured from the rat organs are mainly enteric bacilli and corynebacterium. It was assumed that the endogenous infection was originated from the conditions in which the micro-ecologic system of indigenous intestinal flora was disturbed, immunologic function was suppressed by the overlapped effect of burn and injection of DXM, the biological antagonism among the intestinal flora was attenuated, and the intestinal bacilli overgrew, passed through the epithelia of intestine into lymphatic vessel and mesenteric lymph nodes, then colonized and multiplied in other organs, resulting in endogenous infection.
Shi
Z G
ZG
Research Laboratory, Trauma Center 304th Hospital of PLA.
D000038:Abscess / Q000209:etiology*; D000818:Animals; D002056:Burns / Q000150:complications* / Q000276:immunology; D003907:Dexamethasone; D004064:Digestive System / Q000382:microbiology*; D004756:Enterobacteriaceae Infections / Q000209:etiology*; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D008643:Mesentery; D051381:Rats; D011919:Rats, Inbred Strains; D014781:Viscera / Q000382:microbiology
D003907:Dexamethasone