title: Pathogenesis of vertebral metastasis and epidural spinal cord compression.
abstract: The authors have studied the sequential events in the process of vertebral metastasis that result in spinal cord compression. Different tumor cell lines were injected into the systemic arterial circulation of syngeneic or nude mice, and they were killed at timed intervals after injection or when they became paraplegic. The following observations were made. The tumor cells lodged and grew in the hematopoietic bone marrow of the vertebrae. Cancer cells in the vertebral marrow cavity invaded into the spinal canal through the foramina of the vertebral veins rather than destroying the cortical bone. Tumor cell lines that grew in an infiltrative fashion migrated toward a posterior location in the spinal canal, and compressed the spinal cord from a posterior direction. Tumor cell lines that grew as compact tumors formed a tumor mass at the same location from which the cells emerged from the vertebra, and compressed the cord predominantly from an anterior direction. Radiographic evidence of vertebral metastasis was a late event, and commonly associated with significant compression of the cord and extraosseous tumor. These experimental findings may help to establish better diagnostic and treatment strategies for patients with metastatic disease of the spine.
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642.
authors.forename: F
authors.initials: F
authors.lastname: Arguello
authors.forename: R B
authors.initials: RB
authors.lastname: Baggs
authors.forename: R E
authors.initials: RE
authors.lastname: Duerst
authors.forename: L
authors.initials: L
authors.lastname: Johnstone
authors.forename: K
authors.initials: K
authors.lastname: McQueen
authors.forename: C N
authors.initials: CN
authors.lastname: Frantz
mesh_terms: D000818:Animals; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008546:Melanoma, Experimental / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology; D013117:Spinal Cord Compression / Q000209:etiology*; D013125:Spinal Neoplasms / Q000556:secondary*; D014407:Tumor Cells, Cultured