title: [Role of prostaglandins in the mechanism of the effect of cholecystokinin on the gallbladder].
abstract: Secretion of prostaglandins (Pg) E and F2 alpha in bile in basic condition (without stimulation) and under stimulation with cholecystokinin (CCK) ("Boots", England, 1 unit/kg) in patients with fatty liver with normal (15) and hypokinetic (20) function of gallbladder by radioimmunoassay method was investigated. The mediator role of Pg F2 alpha in the realization of effect of CCK on the contractile function of gallbladder was found. It was concluded, that the disturbance of mediator effect of Pg F2 alpha in the hormone regulation of bile excretion may play an important role in the pathogenesis of biliary dyskinesia. This disturbance of mediator effect of Pg was connected with the reducing of concentration and debit Pg F2 alpha in bile, as well as with the slowing of maximal Pg excretion under stimulation with CCK.
authors.forename: R A
authors.initials: RA
authors.lastname: Vysotskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Loginov
authors.forename: E V
authors.initials: EV
authors.lastname: Tkachenko
mesh_terms: D001646:Bile / Q000737:chemistry; D001657:Biliary Dyskinesia / Q000503:physiopathology; D002766:Cholecystokinin / Q000494:pharmacology*; D015237:Dinoprost / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D005234:Fatty Liver / Q000503:physiopathology; D005704:Gallbladder / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D011863:Radioimmunoassay
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D002766:Cholecystokinin; D015237:Dinoprost
vernacular_title: Rol' prostaglandinov v mekhanizme deĭstviia kholetsistokinina na zhelchnyĭ puzyr'.