Radiolabelled stripped mucin, SM3, monoclonal antibody for immunoscintigraphy of ovarian tumours.
A new monoclonal antibody, SM3, against stripped mucin core protein has been evaluated for the radioimmunoscintigraphy of ovarian cancer. It was radiolabelled with In-111, I-123 and Tc-99m and results showed a sensitivity of 95%, 100% and 100% and an accuracy of 73%, 86% and 100% for malignancy; respectively.
Granowska
M
M
Department of Nuclear Medicine, St. Bartholomew's Hospital, London, England.
Mather
S J
SJ
Jobling
T
T
Naeem
M
M
Burchell
J
J
Taylor-Papadimitriou
J
J
Shepherd
J
J
Britton
K E
KE
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000276:immunology; D008875:Middle Aged; D008969:Molecular Sequence Data; D018396:Mucin-1; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D018396:Mucin-1; D013669:Technetium Tc 99m Medronate