A comparison of the reduction in the K+ activity of the scala media produced by furosemide and ouabain.
The endocochlear potential (EP) and the K+ activity in the scala media of the guinea pig were recorded by means of K(+)-sensitive, double-barrelled microelectrodes in the second turn of the cochlea. EP and K+ change were recorded during the perilymphatic perfusion of furosemide and ouabain. Furosemide produced less of a decrease than ouabain in the K+ activity relative to the EP decrease. These results suggest that furosemide reduces the EP via different mechanisms from the inhibition of the K+ secretion potential.
Shugyo
A
A
Department of Otolaryngology, Kagawa Medical School, Japan.
Mori
N
N
Matsunaga
T
T
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003051:Cochlea / Q000502:physiology; D003053:Cochlear Duct / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology*; D006168:Guinea Pigs; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*
D010042:Ouabain; D005665:Furosemide; D011188:Potassium