[Functional state and adrenergic reactivity of the myocardium in experimental atherosclerosis].
The authors studied the changes in the functional properties of a rabbit heart in protracted alimentary hypercholesterolemia (HCE). It is shown that HCE has a little effect on the characteristics of myocardial contractility and adrenergic sensitivity. In protracted HCE the probability of the occurrence of a myocardial own rhythm in response to the effect of isoprenaline increased. HCE with simultaneous vasopressin administration failed to change the contractile properties of the myocardium but had a marked effect on the adrenoreceptor apparatus. The sensitivity of muscles to isoprenaline and phenylephrine increased significantly. The possibility of the appearance of a myocardial own rhythm increased. The results of the study are indicative of the essential role of vasospasm in the development of atherosclerotic myocardial injuries.
Tishkin
S M
SM
Taranenko
V M
VM
Talaeva
T V
TV
Serfienko
O V
OV
Bratus'
V V
VV
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000187:drug effects*
D002316:Cardiotonic Agents; D011941:Receptors, Adrenergic
Funktsional'noe sostoianie i adrenoreaktivnost' miokarda pri éksperimental'nom ateroskleroze.