title: Effect of body posture on cardiopulmonary function in horses during five hours of constant-dose halothane anesthesia.
abstract: Cardiovascular and respiratory functions were serially characterized in 7 healthy, spontaneously breathing, adult horses (from which food had been withheld) during 5 hours of constant 1.06% alveolar halothane (end-expired halothane concentration of 1.06%; equivalent to 1.2 times the minimal alveolar anesthetic concentration for horses). To enable comparison of temporal results in relation to 2 body postures, horses were studied in lateral recumbency (LR) and dorsal recumbency (DR) on separate occasions. Temporal changes in results of measures of circulation previously reported from this laboratory for horses in LR were confirmed (ie, a time-related increase in systemic arterial blood pressure, cardiac output, stroke volume, and PCV). During DR, systemic arterial blood pressure was initially significantly (P less than 0.05) greater and pulmonary artery pressure less than results at comparable periods during LR. Differences ceased to exist with duration of anesthesia. Except for a greater heart rate at hour 5 of DR, no other significant differences in circulation were found between LR and DR. In general, except for PaO2, measures of ventilation did not change with time in either LR or DR. The PaO2 was significantly greater during LR, compared with DR, but the average did not change significantly with time in either body posture.
authors.affiliation: Department of Surgery, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: E P
authors.initials: EP
authors.lastname: Steffey
authors.forename: A B
authors.initials: AB
authors.lastname: Kelly
authors.forename: D S
authors.initials: DS
authors.lastname: Hodgson
authors.forename: J L
authors.initials: JL
authors.lastname: Grandy
authors.forename: M J
authors.initials: MJ
authors.lastname: Woliner
authors.forename: N
authors.initials: N
authors.lastname: Willits
mesh_terms: D000280:Administration, Inhalation; D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001775:Blood Circulation; D001794:Blood Pressure; D006221:Halothane; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D006736:Horses / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D006221:Halothane