title: HLA phenotypes in patients who have osteosarcoma.
abstract: Human leukocyte antigen (HLA) phenotypes were studied in twenty Japanese patients who had typical osteosarcoma. The HLA-A11 phenotype was found in ten (50 per cent) of the twenty patients, compared with 16.6 per cent of 235 control subjects (chi square = 13.248; p less than 0.0005)--an odds ratio of 5.026. These data suggest that major histocompatibility complex-linked genes may determine susceptibility to osteosarcoma.
authors.affiliation: Department of Orthopaedic Surgery, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Chigira
authors.forename: M
authors.initials: M
authors.lastname: Nagase
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: E
authors.initials: E
authors.lastname: Udagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000276:immunology*; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics; D059870:HLA-A11 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011379:Prognosis
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen