Synthesis and anthelminthic evaluation of 2-amidino-1,3,4-oxa and 1,3,4-thiadiazoles, structurally related to tetramisole.
N-(1,3,4-thiadiazol-2-yl) 1a-1k and N-(1,3,4-oxadiazol-2-yl-) amidines 2a-2g, N-(1,3-thiazol-2-yl) 3a, 3b and N-(1,3-benzothiazol-2-yl-)amidines 4a, 4b were synthesized and tested as anthelminthics, in vitro, against a free nematode (Rhabditis pseudoelongata), against infecting larvae of an intestinal parasite of rats (Nippostrongylus brasiliensis) and against infecting larvae of a filaria (Molinema dessetae).
Loiseau
P R
PR
Laboratories de Chimie Thérapeutique, Faculté de Pharmacie, Toulouse, France.
Bonnafous
M
M
Caujolle
R
R
Payard
M
M
Loiseau
P M
PM
Bories
C
C
Gayral
P
P
D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005368:Filariasis / Q000469:parasitology / Q000517:prevention & control; D005370:Filarioidea; D009348:Nematoda; D009349:Nematode Infections / Q000469:parasitology / Q000517:prevention & control; D009559:Nippostrongylus; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000578:Amidines; D000871:Anthelmintics; D010069:Oxadiazoles; D013830:Thiadiazoles; D013844:Thiazoles