Malignant hyperthermia susceptibility in adult patients with masseter muscle rigidity.
We sought to determine the incidence of malignant hyperthermia (MH) susceptibility in adult patients with a previous episode of masseter muscle rigidity (MMR). The medical records and in vitro contracture test results of all patients over 15 years of age tested for MH because of previous MMR from 1985 to 1988 were reviewed. The number of children (age less than 16 yr) tested for MH because of previous MMR was also determined for the same four-year period, for comparison of coincidence rates. Six of 24 adult patients (25 per cent) were proved MH-susceptible by in vitro contracture testing. No clinical sign associated with the episode of MMR was predictive of MH-susceptibility. Two of six MH-susceptible patients developed acute MH following MMR. In the same four-year period, 75 children were tested for MH-susceptibility because of previous MMR; 44 (59 per cent) had a positive in vitro contracture test. We conclude that the coincidence of MMR and MH-susceptibility is lower in adults than children. Episodes of acute MH do occur after MMR, but the onset of MH may be delayed. Conservative management of MMR in adult patients is recommended.
Allen
G C
GC
Department of Anesthesiology, Hahnemann University, Philadelphia, Pennsylvania 19102-1192.
Rosenberg
H
H
D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia; D008406:Masseter Muscle / Q000503:physiopathology*; D008410:Masticatory Muscles / Q000503:physiopathology*; D008875:Middle Aged; D009119:Muscle Contraction