title: Transient focal neurologic deficits complicating interleukin-2 therapy.
abstract: We report 2 patients with transient, focal, repetitive, stereotyped episodes of neurologic deficits during treatment with interleukin-2. One patient had recurrent monocular blindness, while the 2nd had recurrent homonymous quadrantanopia. We suggest that these attacks are provoked by endothelial cell activation induced by interleukin-2.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: J T
authors.initials: JT
authors.lastname: Bernard
authors.forename: S
authors.initials: S
authors.lastname: Ameriso
authors.forename: R A
authors.initials: RA
authors.lastname: Kempf
authors.forename: P
authors.initials: P
authors.lastname: Rosen
authors.forename: M S
authors.initials: MS
authors.lastname: Mitchell
authors.forename: M
authors.initials: M
authors.lastname: Fisher
mesh_terms: D001766:Blindness / Q000209:etiology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D014786:Vision Disorders / Q000209:etiology*
chemical_list: D007376:Interleukin-2