[The recovery of the mitotic cycle and DNA repair in Chinese hamster cells cultured on a medium with 5-bromodeoxyuridine following the action of ionizing radiation].
A correlation has been shown between a strong decrease in survival of X-irradiated CHO-K1 cells cultured with 5-BudR, a strong inhibition of recovery of DNA single-strand breaks, and an essential increase in G2-delay while progressing through the cell cycle. This strong correlation may point to the involvement of repair processes into the final radiation effect on the cell.
Kirillova
T V
TV
Rozanov
Iu M
IuM
Seregina
T B
TB
Spivak
I M
IM
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D003470:Culture Media; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects*; D005434:Flow Cytometry; D016195:G2 Phase / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects*
D003470:Culture Media; D004277:DNA, Single-Stranded; D001973:Bromodeoxyuridine
Vosstanovlenie mitoticheskogo tsikla i reparatsiia DNK kletok kitaĭskogo khomiachka, kul'tiviruemykh na srede s 5-bromdezoksiuridinom, posle deĭstviia ioniziruiushcheĭ radiatsii.