A mathematical model for the evolutions of anthelmintic resistance in a direct life cycle nematode parasite.
Some of the elements required of a mathematical model for the evolution of anthelmintic resistance in strongylid nematodes are described. The model comprises a series of coupled first order differential equations and assumes the parasite has a direct life cycle with overlapping generations. The parasite-host system involved only a single host. In all the cases considered, drug resistance was assumed to be determined by two alleles at a single autosomal locus. The pretreatment allelic frequencies were maintained by heterozygote advantage involving the mortality of the free-living stages of the parasite. The model suggests that alternating anthelmintic with different modes of action may be a less effective resistance management strategy than administering the same drugs simultaneously.
Smith
G
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Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, PA 19348.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D013320:Strongyloidea / Q000187:drug effects*
D000871:Anthelmintics