Limitation of experimental myocardial infarct size by magnesium sulfate pre-treatment in dogs.
The present study was designed to evaluate the ability of magnesium sulfate (30 mg/kg, iv, 24 hr and 2 hr prior) to limit myocardial infarct size following permanent left coronary artery occlusion in adult mongrel dogs. Non-perfused myocardium which is the area at risk was visualised by injecting methylene blue intraatrially, 24 hr after coronary artery occlusion. The infarcted myocardium was visualised by triphenyl tetrazolium chloride staining. Infarct size (expressed as % of the risk zone) was significantly reduced in the treatment group (P less than 0.001). We conclude that magnesium sulfate exerted a potent prophylactic effect in limiting the infarct size in the dogs with permanent coronary artery occlusion.
Lal
A
A
Department of Pharmacology, Medical College, Amritsar, Punjab.
Sharma
S
S
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology
D008278:Magnesium Sulfate