T-cell subsets and serum immunoglobulin levels in infants born to HIV-seropositive mothers: a longitudinal evaluation.
T-lymphocyte subsets and serum immunoglobulins were assayed in 27 neonates and 12 infants younger than 6 months, all born to HIV-seropositive mothers. No differences in T-lymphocyte subsets between the 27 seropositive and 34 seronegative infants were found at birth. Twelve seroreverted and 14 infected children were followed. CD4+ cell counts were significantly lower in the latter at 3 and 24 months of age. Serum immunoglobulin levels and CD8+ percentages became higher in the infected group, starting from the sixth month, while CD4+ percentages and CD4+/CD8+ ratios became lower, starting from the twelfth month.
d'Arminio Monforte
A
A
Clinic of Infectious Diseases, University of Milan, Italy.
Novati
R
R
Galli
M
M
Marchisio
P
P
Massironi
E
E
Tornaghi
R
R
Saracco
A
A
Principi
N
N
Moroni
M
M
D002675:Child, Preschool; D005260:Female; D006679:HIV Seropositivity / Q000635:transmission*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D015819:Substance Abuse, Intravenous; D016176:T-Lymphocyte Subsets
D007070:Immunoglobulin A; D007075:Immunoglobulin M