title: Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum.
abstract: Monoclonal antibodies, immune bovine serum, and immune bovine colostral whey neutralized infectivity of Cryptosporidium parvum sporozoites for mice in a time-dependent manner. Immune colostral whey neutralized sporozoites more rapidly and completely than immune serum, monoclonal antibody (MAb) 18.44, or a combination of MAb 18.44 and MAb 17.41. Mice were partially protected against oral challenge with C. parvum oocytes when treated with immune colostral whey, MAb 17.41, or a combination of MAb 17.41 and MAb 18.44.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
authors.forename: L E
authors.initials: LE
authors.lastname: Perryman
authors.forename: M W
authors.initials: MW
authors.lastname: Riggs
authors.forename: P H
authors.initials: PH
authors.lastname: Mason
authors.forename: R
authors.initials: R
authors.lastname: Fayer
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002417:Cattle; D003044:Coccidia / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D003458:Cryptosporidium / Q000276:immunology*; D007700:Kinetics; D009500:Neutralization Tests
chemical_list: D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan