Synthesis and pharmacological properties of some derivatives of 3-phenylimidazo[4,5-b]pyridine.
The one-pot synthesis and properties of some derivatives of 3-phenylimidazo [4,5-b]pyridine (4a-g) were described. The central action of compounds 4a, 4f and 4g has been investigated using behavioral tests in mice and rats. The tested compounds showed a potent sedative effect. Compound 4f has central serotoninolytic properties in the m-CPP induced hyperthermia in rats.
Kaczmarek
L
L
Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa.
Nantka-Namirski
P
P
Moryl
E
E
Chojnacka-Wójcik
E
E
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004597:Electroshock; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000138:chemical synthesis*; D013239:Stereotyped Behavior / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D007093:Imidazoles; D011725:Pyridines; D012702:Serotonin Antagonists