Removal of the carboxy terminus of beta-tubulin subunit produces lateral annealing of microtubules with different orientations.
1. Tubulin, lacking the carboxy terminus region of its beta subunit assembles into composite microtubule structures showing opposite polarity. 2. Since in these polymers, microtubules are laterally bound, this type of interaction could lead to the generation of microtubules with different polarities, as those found in some cellular types.
Dominguez
J E
JE
Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma, Madrid, España.
Padilla
R
R
Avila
J
J
Carrascosa
J L
JL
D000818:Animals; D002417:Cattle; D010450:Endopeptidases / Q000378:metabolism; D006868:Hydrolysis; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure*; D055095:Optics and Photonics; D013211:Staphylococcus aureus / Q000201:enzymology; D014404:Tubulin / Q000378:metabolism* / Q000648:ultrastructure
D014404:Tubulin; D010450:Endopeptidases