title: MR imaging in assessment of cardiac transplant rejection in humans.
abstract: To evaluate the efficacy of myocardial T2 values in the assessment of allograft rejection, we performed magnetic resonance (MR) imaging at 0.5 T serially in seven cardiac transplant recipients and singly in seven normal volunteers. Cardiac-gated multi-echo spin echo images were obtained; T2 values were estimated by a two-point method from regions of interest in the myocardium. Patients underwent MR and cardiac biopsy at various times after transplantation. Forty-two patient exams were performed. All biopsies showed either no rejection or early stages of rejection: grade 0 in 8 examinations, grade 1 in 28, and grade 2 in 6. Myocardial T2 values in patients in early stages of cardiac rejection were slightly higher (but not statistically significant) than those in non-rejecting patients and normal volunteers. Although this study did not allow prospective detection of cardiac rejection in our patient group, it demonstrated a trend toward higher T2 values at higher biopsy grades that may indicate an ability to assess more severe stages of transplant rejection.
authors.affiliation: Department of Diagnostic Radiology, Leiden University Hospital, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Doornbos
authors.forename: H
authors.initials: H
authors.lastname: Verwey
authors.forename: C E
authors.initials: CE
authors.lastname: Essed
authors.forename: A H
authors.initials: AH
authors.lastname: Balk
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000328:Adult; D001706:Biopsy; D006084:Graft Rejection; D016027:Heart Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology