Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture.
In a previous paper it has been reported that the repetitive conjunctive stimulation of both a granule cell and an inferior-olivary neuron depresses the synaptic transmission between a cerebellar granule cell and a Purkinje cell, and the repetitive stimulation of only a granule cell potentiates the transmission in a simple culture preparation. This paper demonstrates, by experiments controlling the membrane potential of a postsynaptic Purkinje cell, that the postsynaptic depolarization of a Purkinje cell during activation of a granule cell is both necessary and sufficient to induce the depression, and that the potentiation is induced without the postsynaptic depolarization.
Hirano
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Department of Physiology, School of Medicine, Gunma University, Japan.
D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology*; D004594:Electrophysiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D009847:Olivary Nucleus / Q000166:cytology; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology*