title: [Hypotension caused by intravenous infusion of rifampicin and its relation to the administration schedule].
abstract: It was shown in studies on animals that bolus administration of rifampicin induced hypotension whose severity depended on the rate of the antibiotic administration. When the antibiotic was administered in the 5-, 10- or 15-minute regimen in a dose of 10 mg/kg the maximum decrease in blood pressure was 44, 34 or 21% of the initial level and the maximum antibiotic concentration attained in the blood was 34.4, 27.2 or 22.6 micrograms/ml, respectively. With the infusion for 30 minutes, the maximum antibiotic concentration in the blood was 17.6 micrograms/ml and the blood pressure did not undergo any significant changes. When the rate of the antibiotic infusion was high there was pharmacokinetic heterogeneity of the blood serum and biophase which could lead to unpredictable results. After repeated administrations of rifampicin to the same animals pronounced tachyphylaxis to the antibiotic was noted, which manifested itself in decreasing of hypotension, though the serum antibiotic level was 1.5 to 2 times higher that the initial one. It was concluded that administration of rifampicin in the therapeutic dose equal to 10 mg/kg for 30 minutes was the most sparing regimen for the antibiotic bolus intravenous infusion. Gradual increase in the antibiotic dose and administration rate in patients is possible under careful control of blood pressure and pharmacokinetic studies.
authors.forename: V V
authors.initials: VV
authors.lastname: Berezhinskaia
authors.forename: G V
authors.initials: GV
authors.lastname: Dolgova
authors.forename: A A
authors.initials: AA
authors.lastname: Firsov
authors.forename: K K
authors.initials: KK
authors.lastname: Manuĭlov
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
mesh_terms: D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D007022:Hypotension / Q000139:chemically induced*; D007262:Infusions, Intravenous; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D012293:Rifampin
vernacular_title: Gipotenziia, vyzyvaemaia vnutrivennym vvedeniem rifampitsina, i ee zavisimost' ot rezhima primeneniia antibiotika.