title: Chronic major aphthous stomatitis: oral treatment with low-dose alpha-interferon.
abstract: Two patients with chronic major aphthous stomatitis of at least 3 years duration were treated with single daily oral doses (1,200 IU) of interferon alfa-2 alpha (HuIFN alpha). Both patients responded with complete remission of aphthae within 6 weeks. One patient had no recurrence of the disease during a 6-month observation period. The second patient had a recurrent aphtha approximately 4 weeks after the initial lesion resolved; however, the recurrent lesion was less severe than the patient had historically experienced. Retreatment of the recurrent lesion with HuIFN alpha resulted in complete remission within 1 week, and there were no further recurrences during the 6-month observational period.
authors.affiliation: Amarillo Virology Research, TX.
authors.forename: V A
authors.initials: VA
authors.lastname: Hutchinson
authors.forename: W L
authors.initials: WL
authors.lastname: Mok
authors.forename: J L
authors.initials: JL
authors.lastname: Angenend
authors.forename: J M
authors.initials: JM
authors.lastname: Cummins
authors.forename: A B
authors.initials: AB
authors.lastname: Richards
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D013281:Stomatitis, Aphthous / Q000628:therapy*
chemical_list: D007370:Interferon Type I