title: Tartrate-resistant acid phosphatase (TRAP) activity in serum: potential use in assessing bone resorption in patients with multiple myeloma.
abstract: We measured serum tartrate-resistant acid phosphatase (TRAP) activity in 120 healthy subjects and 35 patients with multiple myeloma as well as urinary hydroxyproline excretion in the myeloma patients. Young subjects (0-18 years) showed higher TRAP levels (ANOVA p less than 0.01) compared with the other age classes due to the more active bone remodelling processes associated with growth. Myeloma patients with bone lytic lesions (MM+) showed higher serum TRAP values than controls (p less than 0.01). Hydroxyproline excretion was higher in MM+ patients but the difference between patients with and without bone lesions was not statistically significant. Our data suggest that serum TRAP activity may be a suitable, simple biochemical test to assess bone turnover in patients with multiple myeloma but that its clinical usefulness as a marker of bone resorption needs further evaluation.
authors.affiliation: Department of Medicine, Geriatric Institute, Pio Albergo Trivulzio, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Monti
authors.forename: A
authors.initials: A
authors.lastname: Scazzoso
authors.forename: G
authors.initials: G
authors.lastname: Calzaferri
authors.forename: I
authors.initials: I
authors.lastname: Santi
authors.forename: E
authors.initials: E
authors.lastname: D'Aprile
authors.forename: E
authors.initials: E
authors.lastname: Cunietti
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001862:Bone Resorption / Q000201:enzymology* / Q000209:etiology / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000201:enzymology* / Q000652:urine; D009363:Neoplasm Proteins / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D000135:Acid Phosphatase; D006909:Hydroxyproline