Intravenous injection of flunarizine elicits epileptiform convulsions. Preliminary evaluation of anti-epileptic drugs.
The possibility to elicit convulsions in rabbits after flunarizine, iv was investigated. A flunarizine solution, 3.3 mg/ml, was given iv at a rate of 1.5 ml/min in three fractional doses every 30 min. Action of anti-epileptic drugs in seizures induced by flunarizine was additionally examined. Convulsive seizures occurred 2-10 min after the last successive dose of flunarizine as alternating clonic and tonic seizures. A treatment with anti-epileptic drugs showed that both phenobarbital at doses 6, 7 and 7.5 mg/kg iv and pentobarbital at doses of 15, 20 and 25 mg/kg, iv did not entirely suppress convulsive seizures, although convulsive episodes were rare. Diazepam at doses of 1-1.5 mg/kg, iv suppressed convulsive seizures.
Roliński
Z
Z
Department of Pharmacology, University of Agriculture, Lublin, Poland.
Tusińska
E
E
Klimont
E
E
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001835:Body Weight / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005444:Flunarizine / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy
D000927:Anticonvulsants; D010424:Pentobarbital; D003975:Diazepam; D005444:Flunarizine; D010634:Phenobarbital