Anti-inflammatory constituents of topically applied crude drugs. IV. Constituents and anti-inflammatory effect of Paraguayan crude drug "alhucema" (Lavandula latifolia Vill.).
The anti-inflammatory active fraction of the Paraguayan crude drug, "Alhucema," Lavandula latifolia Vill. afforded four compounds: coumarin (1), 7-methoxycoumarin (2), trans-phytol (3) and caryophyllene oxide (4). 1 showed a weakly inhibitory effect on carrageenin-induced paw edema in rats on topical application and 4 showed an inhibitory effect on histamine-induced contraction in guinea pig ileum.
Shimizu
M
M
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Shogawa
H
H
Matsuzawa
T
T
Yonezawa
S
S
Hayashi
T
T
Arisawa
M
M
Suzuki
S
S
Yoshizaki
M
M
Morita
N
N
Ferro
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D001681:Biological Assay; D003374:Coumarins / Q000032:analysis*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010239:Paraguay; D010836:Phytol / Q000032:analysis*; D010946:Plants, Medicinal / Q000032:analysis*; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D012717:Sesquiterpenes / Q000032:analysis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D010836:Phytol; C024714:caryophyllene