[A study of the inclusion complex of WB852 with beta-cyclodextrin].
The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with beta-cyclodextrin (beta-CD). The stability of WB852-beta-CD in aqueous solution was determined. The hydrolysis rate of WB852 from the inclusion compound was lower than that of WB852 alone. The solid inclusion compound of WB852 with beta-CD in 1:3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with beta-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA).
Wang
S L
SL
Shenyang College of Pharmacy.
Su
D S
DS
Ji
Z Z
ZZ
D003505:Cyclodextrins; D003517:Cyclopentanes; D004337:Drug Carriers; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D003517:Cyclopentanes; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C067336:WB 852; C031215:betadex