title: The biliary elimination and enterohepatic circulation of ibuprofen in rats.
abstract: The biliary and urinary excretion of ibuprofen and its metabolites were determined in rats after intravenous and peroral administration of 25 and 100 mg/kg of the drug. Within 24 hours 48% of the low i.v. dose and 59% of the high i.v. dose were eliminated via bile as ibuprofen and its metabolites. Following oral administration 40 to 41% of the dose were recovered in bile, whereas 16 to 32% of the dose were eliminated in urine, resulting in an overall drug recovery of 66 to 79% within 24 hours. Upon infusion of bile containing ibuprofen and its metabolites into the duodenum substantial enterohepatic cycling of the drug occurred in the rat.
authors.affiliation: Department of Pharmacology and Toxicology, University of Erlangen-Nuernberg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Dietzel
authors.forename: W S
authors.initials: WS
authors.lastname: Beck
authors.forename: H T
authors.initials: HT
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Geisslinger
authors.forename: K
authors.initials: K
authors.lastname: Brune
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004764:Enterohepatic Circulation; D007052:Ibuprofen / Q000493:pharmacokinetics* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007052:Ibuprofen