[Trophic effect of angiotensin II, vasopressin and oxytocin on the ventral spinal cord of rat embryo].
We studied trophic effects of angiotensin II, vasopressin and oxytocin on explanted ventral spinal cord cultures derived from 13 to 14-old day rat embryos. There was a significant neurite promoting effect in angiotensin II and vasopressin-treated cultures. Angiotensin II had the most potent effect at any concentrations. It became clear that minimum effective concentration was 10(-8)M in both angiotensin II and vasopressin. However, oxytocin had no neurotrophic effect at any concentrations. Our results demonstrated that angiotensin II and vasopressin have a neurotrophic effect on ventral spinal cord in cultures, and may contribute to therapeutic strategy of amyotrophic lateral sclerosis.
Iwasaki
Y
Y
Fourth Department of Internal Medicine, Toho University Ohashi Hospital.
Kinoshita
M
M
Ikeda
K
K
Takamiya
K
K
Shiojima
T
T
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D009414:Nerve Growth Factors; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000254:growth & development*; D014667:Vasopressins / Q000494:pharmacology*
D009414:Nerve Growth Factors; D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin