Effect of gender in centrally induced angiotensin II hypertension in dogs.
This study was designed to investigate the relation between gender, an endogenous inhibitor of the Na+-K+ pump, and volume-dependent hypertension induced by stimulation of the brain renin-angiotensin system and increased salt intake. Angiotensin II (20 ng/min i.c.v.) was infused for 4 weeks in five dogs of each sex with saline as the drinking fluid. In male dogs, angiotensin II induced parallel pressor (30%) and dipsogenic responses (70%), whereas no hypertension and no increase in fluid intake were observed in females. In contrast, the activity of the Na+-K+ pump as assessed by 86Rb uptake was independent of gender. Our data provide novel evidence that gender plays a determining role in the physiological properties of centrally administered angiotensin II.
Doursout
M F
MF
Department of Anesthesiology, University of Texas Medical School, Houston.
Chelly
J E
JE
Wouters
P
P
Lawrence
C
C
Liang
Y Y
YY
Buckley
J P
JP
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D012413:Rubidium / Q000493:pharmacokinetics; D012727:Sex Characteristics; D013623:Tail / Q000098:blood supply
D000804:Angiotensin II; D010042:Ouabain; D012413:Rubidium