Karyotypic changes identified by HaeIII restriction endonuclease banding in a patient with M2 acute non-lymphoblastic leukemia.
A patient with acute non-lymphoblastic leukemia, FAB type M2, showed a complex karyotype involving chromosomes 1 and 11. The breakpoints could not be exactly identified by GTG and QFQ banding. A subsequent analysis with Alul and HaeIII restriction enzyme staining allowed the detection of a translocation of the heterochromatic region of chromosome 1 to 11q21.
Stuppia
L
L
Institute of Biology and Genetics, University of Chieti, Italy.
Palka
G
G
Fioritoni
G
G
Calabrese
G
G
Guanciali Franchi
P
P
D'Arcangelo
L
L
Torlontano
G
G
D000368:Aged; D002871:Chromosome Banding / Q000379:methods*; D015252:Deoxyribonucleases, Type II Site-Specific; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics
D015252:Deoxyribonucleases, Type II Site-Specific; C024403:GGCC-specific type II deoxyribonucleases