title: [Comparative study of sulfadoxine-pyrimethamine and amodiaquine + sulfadoxine-pyrimethamine for the treatment of malaria caused by chloroquine-resistant Plasmodium falciparum in Maputo, Mozambique].
abstract: To compare the efficacy and side-effects of two therapeutic regimens for chloroquine-resistant falciparum malaria, a randomized study was carried out in 69 patients in Maputo Central Hospital in 1986-1987. The two treatments were sulfadoxine 25 mg/kg + pyrimethamine 1.25 mg/kg as a single dose (S + P) and amodiaquine 10 + 10 + 5 mg/kg over three days with sulfadoxine + pyrimethamine on the third day (A + S + P). The cure rate was 25/29 (86%) with S + P and 27/30 (90%) with A + S + P. No serious side-effects were observed. The probably slightly higher cure rate with the triple combination is hardly of clinical importance in semi-immune patients, but may theoretically help retard the development of resistance to sulfadoxine-pyrimethamine. This point and the question of the incidence of side-effects with the two regimens should be made the object of an epidemiological study.
authors.affiliation: Servicio de Medicina Interna, Hospital Central de Maputo, Mozambique.
authors.forename: D V
authors.initials: DV
authors.lastname: Dinis
authors.forename: A
authors.initials: A
authors.lastname: Schapira
mesh_terms: D000328:Adult; D000655:Amodiaquine / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology; D004338:Drug Combinations; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008288:Malaria / Q000188:drug therapy*; D009073:Mozambique; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000009:adverse effects / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D006454:Hemoglobins; D000655:Amodiaquine; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine
vernacular_title: Etude comparative de la sulfadoxine-pyriméthamine et de l'amodiaquine + sulfadoxine-pyriméthamine dans le traitement du paludisme à Plasmodium falciparum chloroquino-résistant à Maputo, Mozambique.