[Effects of nicardipine on beating rates of cultured myocardial cells].
Nicardipine (Nic) 15 nmol/L had no effects on beating rates of cultured myocardial cells. Nic 75 and 150 nmol/L depressed the beating rates significantly. Rapid standstills occurred earlier and more in 150 nmol/L group than in 75 nmol/L. Both isoproterenol and CaCl2 restored the beating depressed by Nic. However, only CaCl2 prevented the standstill. These results suggest that nicardipine may compete with calcium in excitation-contraction coupling.
Yang
J C
JC
Department of Pharmacology, First Miltary Medical College, Guangzhou, China.
Yu
C L
CL
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology*; D009529:Nicardipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009529:Nicardipine; D007545:Isoproterenol; D002122:Calcium Chloride