title: Diet and histologic types of benign breast disease defined by subsequent risk of breast cancer.
abstract: The authors investigated the relation between diet and histologic types of benign breast disease defined by subsequent risk of breast cancer in a case-control study of volunteers who entered the Vancouver Center of the Canadian National Breast Screening Study between 1983 and 1985. Proliferative benign breast disease (n = 124) was inversely associated with vitamin A supplementation (vitamin A user vs. nonuser, odds ratio (OR) = 0.5) and frequent green vegetable consumption (frequent vs. rare consumption, OR = 0.3), whereas severe atypias and borderline carcinoma in situ (n = 32) were directly associated with frequent meat fats consumption (frequent vs. rare consumption, OR = 3.2) with no association with vitamin A or vegetable consumption. No dietary relations were found for histologic types of benign breast disease at no increased risk for subsequent breast cancer (n = 274). The implications of these findings in relation to the etiology of breast cancer are discussed.
authors.affiliation: Division of Epidemiology, Biometry and Occupational Oncology, Cancer Control Agency of British Columbia, Vancouver, Canada.
authors.forename: T G
authors.initials: TG
authors.lastname: Hislop
authors.forename: P R
authors.initials: PR
authors.lastname: Band
authors.forename: M
authors.initials: M
authors.lastname: Deschamps
authors.forename: V
authors.initials: V
authors.lastname: Ng
authors.forename: A J
authors.initials: AJ
authors.lastname: Coldman
authors.forename: A J
authors.initials: AJ
authors.lastname: Worth
authors.forename: T
authors.initials: T
authors.lastname: Labo
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D001955:British Columbia; D016022:Case-Control Studies; D004041:Dietary Fats / Q000009:adverse effects; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D016017:Odds Ratio; D011230:Precancerous Conditions / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014801:Vitamin A
chemical_list: D004041:Dietary Fats; D014801:Vitamin A