title: A double-blind amino acids, L-tryptophan and L-tyrosine, and placebo study with cocaine-dependent subjects in an inpatient chemical dependency treatment center.
abstract: In a six-month double-blind study in an inpatient chemical dependency facility, 29 cocaine-dependent subjects were studied to determine if the amino acids, L-tryptophan and L-tyrosine, would decrease cocaine craving and withdrawal symptoms. Those subjects receiving placebo were shown to have a statistically significant increase in only one physical symptom category. The drug craving and other major physical and subjective symptoms were not shown to be significant. This study is consistent with a literature review in demonstrating that the amino acids do not significantly reduce most symptoms of cocaine craving and withdrawal when used alone.
authors.affiliation: Family Physicians, Columbus, Indiana 47201.
authors.forename: M J
authors.initials: MJ
authors.lastname: Chadwick
authors.forename: D L
authors.initials: DL
authors.lastname: Gregory
authors.forename: G
authors.initials: G
authors.lastname: Wendling
mesh_terms: D000293:Adolescent; D000328:Adult; D003042:Cocaine / Q000009:adverse effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008950:MMPI; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000523:psychology / Q000534:rehabilitation*; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D014364:Tryptophan / Q000008:administration & dosage*; D014443:Tyrosine / Q000008:administration & dosage*
chemical_list: D014443:Tyrosine; D014364:Tryptophan; D003042:Cocaine