[Clinical study of the efficacy and tolerability of nimesulide in suppositories compared to flurbiprofen in gynecology].
The efficacy and tolerability of nimesulide in a new pharmaceutical suppository form were assessed in a double blind study versus flurbiprofen in pain-inflammatory pathologies of obstetrico-gynecological nature. One hundred patients with pelvic inflammatory disease were randomly assigned to treatment with nimesulide or flurbiprofen. Both drugs, administered in a dose of 2 suppositories a day for 7 days, evidenced speedy, effective analgesic and anti-inflammatory activity combined with good tolerability. Specifically, as regards the pain component, nimesulide demonstrated a significantly more marked analgesic effect than flurbiprofen in the first two hours of treatment.
Montoneri
C
C
Istituto di I Clinica Ostetrica e Ginecologica, Università di Catania, Ospedale Vittorio Emanuele II.
Garofalo
A
A
Iurato
S
S
Scaricabarozzi
I
I
Trezzani
R
R
D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000009:adverse effects; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D013488:Suppositories
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D013488:Suppositories; D005480:Flurbiprofen; C012655:nimesulide
Studio clinico sull'efficacia e la tollerabilità della nimesulide in formulazione supposte in confronto al flurbiprofen in ginecologia.