title: Autoantibodies against triosephosphate isomerase. A possible clue to pathogenesis of hemolytic anemia in infectious mononucleosis.
abstract: In sera from patients with acute EBV, infection and the clinical symptoms of infectious mononucleosis antibodies of the Ig class M were found that are directed against two cellular proteins. The molecular mass of these proteins was determined to be 29 (p29) and 26 kD (p26), respectively, in SDS-PAGE. P29 was identified as part of the glycolytic enzyme triosephosphate isomerase (TPI) by comparison of the NH2-terminal amino acid sequences. A purified antibody against TPI induces a 51Cr release from human erythrocytes. Possibly, anti-TPI causes hemolysis, which is an infrequent but serious symptom of infectious mononucleosis.
authors.affiliation: Department of Medical Microbiology, University of Göttingen, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Ritter
authors.forename: H
authors.initials: H
authors.lastname: Brestrich
authors.forename: B
authors.initials: B
authors.lastname: Nellen
authors.forename: H
authors.initials: H
authors.lastname: Kratzin
authors.forename: H
authors.initials: H
authors.lastname: Eiffert
authors.forename: R
authors.initials: R
authors.lastname: Thomssen
mesh_terms: D000595:Amino Acid Sequence; D000743:Anemia, Hemolytic / Q000150:complications / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002238:Carbohydrate Epimerases / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008969:Molecular Sequence Data; D011817:Rabbits; D014305:Triose-Phosphate Isomerase / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D002238:Carbohydrate Epimerases; D014305:Triose-Phosphate Isomerase