title: Autolysed antigen-extracted allogeneic bone for repair of diaphyseal bone defects in rabbits.
abstract: Autolysed antigen-extracted allogeneic bone (AAA bone) was used to bridge a large osteoperiosteal gap in the diaphysis of the radius of 50 rabbits. Periodic observations of the graft were made clinically, radiologically and histologically every week up to fourteen weeks. The continuity of the radius was evaluated macroscopically and histologically. The AAA bones were progressively resorbed and replaced by the new bone. The bone remodelled to the mature tubular bone and did not undergo absorption during the experimental period. The AAA bone proceeded to be an osteoinductive and osteoconductive material. There were no appreciable histologic signs of immune or foreign body reaction.
authors.affiliation: Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: C D
authors.initials: CD
authors.lastname: Han
authors.forename: H J
authors.initials: HJ
authors.lastname: Kang
authors.forename: E S
authors.initials: ES
authors.lastname: Kang
authors.forename: K H
authors.initials: KH
authors.lastname: Shin
authors.forename: N H
authors.initials: NH
authors.lastname: Kim
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000276:immunology; D001842:Bone and Bones / Q000276:immunology; D006085:Graft Survival; D011817:Rabbits; D014184:Transplantation, Homologous / Q000276:immunology