[Elimination of secretions in CF patients under amiloride inhalation].
Inhaled amiloride reduces active absorption of sodium of respiratory epithelium in CF patients and so, transiently, diminishes loss of water. 10 CF patients, 8 to 28 years of age, were examined on two days. First day, they inhaled in a randomised order isotonic saline and a solution of amiloride hydrochloride (0.3 mg/ml) one after another, each inhalation taking twenty minutes. Second day, inhalations were performed in an inverse order. To intensify the effect of inhalation, the inhalation procedure was combined with "autogenic drainage", a special kind of physiotherapy. Main criterion for evaluation was the amount of expectorated sputum. Mean increase of sputum during amiloride inhalation in comparison to saline was +50.4%. Patients and physiotherapist observed a liquefaction of secretion and a decrease of coughing by amiloride and a support of physiotherapy. These results suggest a beneficial clinical effect of regular amiloride inhalation in CF patients.
Lindemann
H
H
Zentrum für Kinderheilkunde, Justus-Liebig-Universität Giessen.
Becker
T
T
Bittner
P
P
Boldt
A
A
Hofmann
T
T
Schwandt
H J
HJ
D000042:Absorption; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000584:Amiloride / Q000008:administration & dosage*; D001326:Autogenic Training; D002648:Child; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012964:Sodium / Q000378:metabolism; D013183:Sputum / Q000378:metabolism*
D000584:Amiloride; D012964:Sodium
Sekretelimination bei CF-Patienten unter Amiloridinhalation.