title: [14Co-dimetinur distribution in mice in relation to the stage of the development of tumor process].
abstract: Pharmacokinetics of the antitumour agent 14CO-dimetinur (100 mg/kg) after oral administration to the intact mice and those with solid leukemia P 388 is characterized by its rapid delivery to organs and tumours with the achievement of maximum radioactivity 5 hours later and the further gradually decline during 4 days. The increased accumulation of the 14CO-products in kidneys and their retarded output from the brain and lungs against a background of the relatively equal distribution of radioactivity between other tested organs have been established. The same level of carbamoylated products in large tumours (the 16th day after leukemia transplantation) as well as in small tumours (the 9th day after inoculation) is in agreement with the conservation of the initial marked inhibitory effect of the drug against advanced tumours.
authors.forename: L A
authors.initials: LA
authors.lastname: Ostrovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Rykova
authors.forename: A A
authors.initials: AA
authors.lastname: Kondarov
authors.forename: L
authors.initials: L
authors.lastname: Etvesh
authors.forename: E
authors.initials: E
authors.lastname: Shimon-Trompler
authors.forename: I S
authors.initials: IS
authors.lastname: Sokolova
authors.forename: D B
authors.initials: DB
authors.lastname: Korman
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003036:Cobalt Isotopes; D007941:Leukemia P388 / Q000188:drug therapy* / Q000473:pathology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000031:analogs & derivatives; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D003036:Cobalt Isotopes; C001049:N,N'-dimethylnitrosourea; D008770:Methylnitrosourea
vernacular_title: Raspredelenie 14Co-dimetinura v organizme mysheĭ v zavisimosti ot stadii razvitiia opukholevogo protsessa.