Improvement of action myoclonus by an administration of 5-hydroxytryptophan and carbidopa in a child with muscular subsarcolemmal hyperactivity.
We report a 3-year-11-month-old boy who manifested action myoclonus only. Histochemical analysis of the quadriceps muscle revealed subsarcolemmal hyperactivity. The administration of 5-hydroxytryptophan and carbidopa dramatically improved the action myoclonus and reduced an amplitude of giant somatosensory evoked potentials. A nosological relation of this case with "essential myoclonus" and mitochondrial encephalomyopathy was discussed.
Nakano
K
K
Department of Pediatrics, Tokyo Women's Medical College, Japan.
Hayakawa
T
T
Shishikura
K
K
Ohsawa
M
M
Suzuki
H
H
Fukuyama
Y
Y
D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009207:Myoclonus / Q000188:drug therapy* / Q000209:etiology
D006916:5-Hydroxytryptophan; D002230:Carbidopa