Influence of conditioned medium pretreatment on marrow recovery in sublethally irradiated mice.
Intraperitoneal administration of medium conditioned by thymocytes (TCCM) 18 h before whole-body irradiation with a single sublethal dose of 5.8 Gy stimulates haemopoiesis recovery in mouse bone marrow. Cellularity of femoral bone marrow in animals treated with TCCM was greater by 20-60% within 10-30 days after irradiation than that in mice only irradiated. CFU-S number was 1.5 to 2-fold higher at the same period. Histological examination showed a considerably higher rate of myelopoiesis recovery in bone marrow.
Brezáni
P
P
Department of General Biology, Faculty of Science, P.J. Safárik University, Kosice.
Fedorocko
P
P
Macková
N
N
D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D001853:Bone Marrow / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D003470:Culture Media; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D007962:Leukocytes / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011837:Radiation-Protective Agents; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology*; D014916:Whole-Body Irradiation
D001685:Biological Factors; D003470:Culture Media; D011837:Radiation-Protective Agents