Isoproteins and an isoelectric focusing mutant of human apoprotein serum amyloid A.
On isoelectric focusing of human plasma and subsequent immunoblotting, using antii-human serum amyloid A (SAA) antibodies, a genetic variant of SAA was detected in a family of Turkish origin. All affected members of the family were apparent heterozygotes for the mutant protein, which underwent a charge shift of about one charge unit toward the anode. The variant is likely to be a mutant of the most prominent forms of SAA (SAA1 and SAA2, or SAA1 and SAA1 des Arg). The appearance of a genetic variant of two of the six reported SAA-isoforms in human plasma supports the concept of SAA proteins being products of different genes.
Steinmetz
A
A
Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universität, Marburg, Federal Republic of Germany.
Schmidt
B
B
Hocke
G
G
Motzny
S
S
Vitt
H
H
Kaffarnik
H
H
D000917:Antibody Formation; D015153:Blotting, Western; D014644:Genetic Variation; D006801:Humans; D007525:Isoelectric Focusing; D009154:Mutation; D010375:Pedigree; D012689:Sequence Homology, Nucleic Acid; D000685:Serum Amyloid A Protein / Q000235:genetics*
D000685:Serum Amyloid A Protein