title: Growth hormone receptors in hypothalamic and extra-hypothalamic tissues.
abstract: Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for 125I-labelled GH. RNA extracted from hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains contained mRNA that hybridized with a cDNA probe for the rabbit liver GHR. This transcript was of a similar size to the major GHR mRNA moiety in rabbit liver. The expression of these moieties was age related, and higher in adult than in neonatal animals.
authors.affiliation: Department of Physiology, University of Alberta, Edmonton, Canada.
authors.forename: R A
authors.initials: RA
authors.lastname: Fraser
authors.forename: D
authors.initials: D
authors.lastname: Attardo
authors.forename: S
authors.initials: S
authors.lastname: Harvey
mesh_terms: D000367:Age Factors; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D001923:Brain Chemistry; D002645:Chickens; D015342:DNA Probes / Q000138:chemical synthesis; D007031:Hypothalamus / Q000737:chemistry*; D008099:Liver; D015347:RNA Probes / Q000138:chemical synthesis; D011817:Rabbits; D011986:Receptors, Somatotropin / Q000032:analysis / Q000502:physiology*
chemical_list: D015342:DNA Probes; D015347:RNA Probes; D011986:Receptors, Somatotropin