title: Radiation exposure and chromosome abnormalities. Human cytogenetic studies at the National Institute of Radiological Sciences, Japan, 1963-1988.
abstract: The results of human cytogenetic studies performed at the National Institute of Radiological Sciences (NIRS), Chiba, Japan for about 25 years are described. The studies were pursued primarily under two major projects: one involving people exposed to radiation under various conditions and the other involving patients with malignant diseases, especially leukemias. Whereas chromosome abnormalities in radiation-exposed people are excellent indicators of radiation exposure, their behavior in bone marrow provide useful information for a better understanding of chromosome abnormalities in leukemias and related disorders. The role of chromosome abnormalities in the genesis and development of leukemia and related disorders is considered, suggesting a view for future studies in this field.
authors.affiliation: Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: S
authors.initials: S
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Minamihisamatsu
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D009689:Nuclear Warfare; D011832:Radiation Injuries / Q000235:genetics*; D011833:Radiation Injuries, Experimental / Q000235:genetics; D051381:Rats; D012307:Risk Factors; D013911:Thorium Dioxide / Q000009:adverse effects
chemical_list: D013911:Thorium Dioxide