title: Long term high dose morphine, ketamine and midazolam infusion in a child with burns.
abstract: The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days. The mean plasma clearance of morphine was 29 ml min-1 kg-1 and the plasma ratios of morphine-6-glucuronide to morphine were similar to those previously reported in children. The mean plasma clearance of ketamine was 32 ml min-1 kg-1 which is greater than that previously reported in older children and adults. There were no complications despite high dose long term therapy with morphine, ketamine and midazolam.
authors.affiliation: Department of Anaesthesiology, University Hospital, Linköping, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Cederholm
authors.forename: M
authors.initials: M
authors.lastname: Bengtsson
authors.forename: S
authors.initials: S
authors.lastname: Björkman
authors.forename: I
authors.initials: I
authors.lastname: Choonara
authors.forename: A
authors.initials: A
authors.lastname: Rane
mesh_terms: D002056:Burns / Q000097:blood / Q000378:metabolism*; D002059:Burns, Inhalation / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007649:Ketamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008874:Midazolam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009020:Morphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D007649:Ketamine; D009020:Morphine; D008874:Midazolam