title: Five-year follow-up of helium ion therapy for uveal melanoma.
abstract: One hundred sixty-four patients with uveal melanoma were treated with helium ion irradiation prior to May 1984, and the data were analyzed in June 1989. Most uveal melanomas were large, with a mean tumor thickness of 6.5 mm; approximately 60% of the patients had tumors that extended anterior to the equator. A complete follow-up was obtained for all patients. One hundred twelve patients were alive at the time of this report; 18% of the patients developed clinical and laboratory evidence of metastases and eventually died of widespread tumor. Eighty-four percent of eyes were retained. Data were analyzed with a number of parametric and nonparametric techniques. Larger tumors and those located in close proximity to the optic nerve and fovea had a higher incidence of most complications, especially visual loss.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco 94143.
authors.forename: D H
authors.initials: DH
authors.lastname: Char
authors.forename: J R
authors.initials: JR
authors.lastname: Castro
authors.forename: S M
authors.initials: SM
authors.lastname: Kroll
authors.forename: A R
authors.initials: AR
authors.lastname: Irvine
authors.forename: J M
authors.initials: JM
authors.lastname: Quivey
authors.forename: R D
authors.initials: RD
authors.lastname: Stone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology; D005069:Evaluation Studies as Topic; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D015355:Glaucoma, Neovascular / Q000209:etiology; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D008875:Middle Aged; D011379:Prognosis; D011868:Radioisotopes / Q000627:therapeutic use*; D014604:Uveal Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D014792:Visual Acuity
chemical_list: D011868:Radioisotopes; D006371:Helium