title: Amino acids and peptides. XXVII. Synthesis of phytochelatin-related peptides and examination of their heavy metal-binding properties.
abstract: Phytochelatin (PC)-related peptides were prepared by a conventional solution method and their heavy metal-binding properties were examined. Different from the Cu2+ and Cu+ -binding properties of metallothionein (MT)-related peptides, the Cu2+ and Cu+ -binding properties of PC-related peptides were fairly dependent on structure. It is of interest that gamma-Glu-Cys-Gly (glutathione) exhibited quite different Cu2+ and Cu+ -binding properties from those of other PC-related peptides and its binding abilities were comparable to those of MT-related peptides. The Cd2+ -binding properties of glutathione were similar to those of Cys, and the Cd2+ -binding abilities of PC-related peptides increased in proportion to the increase of gamma-Glu-Cys peptide unit.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Nishi-ku, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: K S
authors.initials: KS
authors.lastname: Min
authors.forename: S
authors.initials: S
authors.lastname: Onosaka
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D005656:Fungal Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010940:Plant Proteins / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005656:Fungal Proteins; D008670:Metals; D010455:Peptides; D010940:Plant Proteins