title: Subclinical renal dysfunction in rheumatoid arthritis.
abstract: We studied renal function in 35 patients with chronic, seropositive rheumatoid arthritis (RA), of whom 7 had vasculitis, 10 had hypergammaglobulinemia, and 18 had neither of these 2 conditions. Findings included a decreased glomerular filtration rate in 8 patients, (micro)proteinuria in 11, a defective urine concentration in 10, and increased urinary tubular enzyme levels in 15. These results indicate that subclinical renal dysfunction is common in patients with chronic, seropositive RA. In addition, vasculitis and hypergammaglobulinemia were not identified as risk factors for renal dysfunction in the RA patients studied.
authors.affiliation: Department of Rheumatology, University Hospital, Leiden, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Boers
authors.forename: B A
authors.initials: BA
authors.lastname: Dijkmans
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
authors.forename: J A
authors.initials: JA
authors.lastname: Camps
authors.forename: P C
authors.initials: PC
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: van Brummelen
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
authors.forename: A
authors.initials: A
authors.lastname: Cats
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D003401:Creatine / Q000652:urine; D005919:Glomerular Filtration Rate; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology; D014657:Vasculitis / Q000209:etiology
chemical_list: D003401:Creatine