title: Randomised single blind trial to compare the toxicity of subconjunctival gentamicin and cefuroxime in cataract surgery.
abstract: Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p less than 0.001). Gentamicin is associated with more pain postoperatively (p less than 0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum.
authors.affiliation: Department of Ophthalmology, St Thomas's Hospital, London.
authors.forename: C D
authors.initials: CD
authors.lastname: Jenkins
authors.forename: P J
authors.initials: PJ
authors.lastname: McDonnell
authors.forename: D J
authors.initials: DJ
authors.lastname: Spalton
mesh_terms: D002387:Cataract Extraction; D002444:Cefuroxime / Q000009:adverse effects*; D003228:Conjunctiva / Q000187:drug effects; D003229:Conjunctival Diseases / Q000139:chemically induced; D004487:Edema / Q000139:chemically induced; D009877:Endophthalmitis / Q000517:prevention & control; D005130:Eye Hemorrhage / Q000139:chemically induced; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007430:Intraoperative Care; D015588:Observer Variation; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D005839:Gentamicins; D002444:Cefuroxime