[Synthesis and CNS- activity of cis-pyrano[2,3-b]-[1,4]dioxane derivatives ].
The alcohols 2, the amines 5, 7 and 10, the indole- and quinoline-derivatives 13 and 14, the enamines 3 and 4 and the silylenolethers 17 and 18 were prepared starting with the title compound 1. The 1-(7-phenyl-7-pyranodioxinyl)-piperidines 10-cis and 10-trans show striking CNS-activity. The transisomer is about twice as active as the cis-isomer.
Eiden
F
F
Institut für Pharmazie und Lebensmittelchemie, Universität München.
Wünsch
B
B
Schünemann
J
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D051379:Mice; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D004146:Dioxanes; D010880:Piperidines; D011714:Pyrans; D006591:Hexobarbital
Synthese und ZNS-Wirkungen von cis-Pyrano[2,3-b]-[1,4]-dioxanderivaten.