title: Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum.
abstract: Cryptosporidium is a parasite of the human gastrointestinal tract that can cause life-threatening diarrhea in immunodeficient patients. Although more than 80 agents have been tried with occasional anecdotal success, treatment remains primarily limited to hydration. A 38-yr-old homosexual man with antibody to human immunodeficiency virus and Cryptosporidium-related diarrhea is described. The patient excreted 6-12 L of stool per day for at least 3 mo, 2 of them spent in the hospital. Trials with more than 6 antidiarrheal medications were ineffective. The patient received bovine colostrum hyperimmune to Cryptosporidium by direct duodenal infusion. During infusion, the patient's fecal output decreased to less than 2 L per day, and 48 h after treatment, stools were formed and oocysts to Cryptosporidium were absent. The patient remained asymptomatic for 3 mo. Hyperimmune bovine colostrum offers an exciting new therapy for cryptosporidiosis; controlled trials to establish efficacy should be undertaken and the active factor(s) characterized.
authors.affiliation: Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: B L
authors.initials: BL
authors.lastname: Ungar
authors.forename: D J
authors.initials: DJ
authors.lastname: Ward
authors.forename: R
authors.initials: R
authors.lastname: Fayer
authors.forename: C A
authors.initials: CA
authors.lastname: Quinn
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000818:Animals; D002417:Cattle; D003126:Colostrum; D003457:Cryptosporidiosis / Q000150:complications / Q000628:therapy*; D003967:Diarrhea / Q000469:parasitology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male