[The effect of D-penicillamine on the immunological indices of rheumatoid arthritis patients].
In 25 patients with rheumatoid arthritis the action of D-penicilamine (Cuprenyl) on the following indices was studied: IgG, IgA, IgM, circulating immune complexes (CIC), rheumatoid factor titer (RF), T- and B-lymphocytes in the peripheral blood. The action on some clinico-laboratory indices was also studied--joint index, duration of morning stiffness, erythrocytes sedimentation rate. The results reveal that the D-penicilamine treatment leads to a lowering of the immunoglobulins, circulating immune complexes and rheumatoid factor titer which is most expressed between the 3 and 6 month from the beginning of the treatment. This drug does not influence significantly the percentage of T- and B-lymphocytes in the peripheral blood.
Sheĭtanov
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I
D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D002214:Capsules; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*
D002214:Capsules; D010396:Penicillamine
Prouchvane efekta na D-penitsilamina vŭrkhu niakoi imunologichni pokazateli pri bolni ot revmatoiden artrit.