title: [Insulin counter-regulation in multiple sclerosis].
abstract: Fasting hypoglycemia is frequently observed in patients with Multiple Sclerosis (S.M.) showing orthostatic hypotension and defective thermoregulation, although they never complicate in hypoglycemic coma. The aim of this study was to evaluate glucose homeostasis in S.M. patients. Both insular and counter-insular regulating mechanisms were investigated by determination of glucose, insulin, C-peptide and cortisol plasmatic levels during OGTT, and subsequently by evaluating glucagon plasmatic levels after arginine administration (30 g., i.v.). Our results suggest that the increased susceptibility of S.M. patients to undergo fasting hypoglycemia could be related to some alterations in counter-insular mechanisms, generally included among neurovegetative modifications in S.M. patients and probably due to orthosympathetic function impairment.
authors.affiliation: Istituto Clinica Medica I, Università di Bari.
authors.forename: V
authors.initials: V
authors.lastname: Procacci
authors.forename: R A
authors.initials: RA
authors.lastname: Altavilla
authors.forename: M G
authors.initials: MG
authors.lastname: Roberto
authors.forename: D
authors.initials: D
authors.lastname: Chicco
authors.forename: N
authors.initials: N
authors.lastname: Antonacci
authors.forename: G
authors.initials: G
authors.lastname: Vendemiale
authors.forename: E
authors.initials: E
authors.lastname: Altomare
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000209:etiology* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein; D005934:Glucagon; D006854:Hydrocortisone
vernacular_title: La controregolazione insulare nella sclerosi multipla.