title: [Second neoplasms in malignant hematologic disorders. Experience from 1978 to 1987].
abstract: Neoplasia may develop in patients with malignant hematologic disorders, during remission after radio and/or chemotherapy. A multifactorial origin related to therapy may be postulated. From 1978 to 1987, among 142 patients with malignant hematologic disorders (Hodgkin lymphoma 33, non-Hodgkin lymphoma 51, Multiple Myeloma 35 and Chronic Myeloid Leukemia 31) we observed 3 patients developing another neoplasia. An additional patient with acute non-lymphatic leukemia had been submitted to chemotherapy for gastric cancer. Four other patients with double neoplasia, one of them a hematologic one, had not been submitted to chemotherapy. The lack of national registries for neoplastic diseases precludes an estimation of the odd ratios involved in our findings.
authors.affiliation: Instituto de Investigaciones Hematológicas Rodolfo Virchow, Facultad de Medicina, Universidad Austral de Chile, Valdivia.
authors.forename: A
authors.initials: A
authors.lastname: Cristoffanini
authors.forename: C
authors.initials: C
authors.lastname: Zapata
authors.forename: A
authors.initials: A
authors.lastname: León
authors.forename: P
authors.initials: P
authors.lastname: Salas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D012189:Retrospective Studies
vernacular_title: Segundas neoplasias en hemopatías malignas. Experiencia en el período 1978-1987.