title: Single dose fosfomycin trometamol versus multiple dose nitrofurantoin in pregnant women with bacteriuria: preliminary results.
abstract: Pregnancy induces anatomical and physiological changes in the urinary tract. In this condition a bacteriuria, even asymptomatic, may lead more frequently to pyelonephritis. Asymptomatic bacteriuria in pregnant women has therefore got to be treated. According to recent studies, long course antibiotherapy did not prove to be more effective than a single-dose one in the case of non-complicated bacteriuria. Moreover, the maternal and foetal toxicity should be reduced in the latter regimen. In this paper we present the preliminary results of our study comparing a single-dose treatment by fosfomycin trometamol (3 g) and nitrofurantoin (200 mg per day during a week).
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital, Liège, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Thoumsin
authors.forename: M
authors.initials: M
authors.lastname: Aghayan
authors.forename: R
authors.initials: R
authors.lastname: Lambotte
mesh_terms: D000284:Administration, Oral; D001437:Bacteriuria / Q000150:complications / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D005578:Fosfomycin; D009582:Nitrofurantoin