Influence of 1,4-benzoquinone derivatives and azomethines on microtubule formation in vitro and experimental leukemias.
Using two groups of substances (derivatives of 1,4-benzoquinone and azomethines) it was compared their effect on the microtubule formation in vitro and on experimental leukemias. 9 from the 28 substances tested acted cancerostatically, 4 substances inhibited microtubule assembly. 3 compounds (fluorenoneazomethines) revealed both effects.
Schulze
W
W
Academy of Sciences, Central Institute of Microbiology and Experimental Therapy, Jena, GDR.
Gutsche
W
W
Vater
W
W
Oertel
B
B
Böhm
K J
KJ
Unger
E
E
Werner
W
W
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008870:Microtubules / Q000187:drug effects*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D013552:Swine
D000970:Antineoplastic Agents; D016227:Benzoquinones; D012545:Schiff Bases