Reduction of delayed neuronal death by inhibition of protein synthesis.
Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed 'killer protein' is required, possibly due to deprivation of nerve growth factor or other trophic factors.
Shigeno
T
T
Department of Neurosurgery, Saitama Medical Center, Saitama Medical School, Japan.
Yamasaki
Y
Y
Kato
G
G
Kusaka
K
K
Mima
T
T
Takakura
K
K
Graham
D I
DI
Furukawa
S
S
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000473:pathology*; D009474:Neurons / Q000187:drug effects / Q000473:pathology*; D011500:Protein Synthesis Inhibitors; D011712:Pyramidal Tracts / Q000187:drug effects / Q000473:pathology*; D012016:Reference Values
D011500:Protein Synthesis Inhibitors; D000841:Anisomycin