Autologous transplantation of the superior cervical ganglion into the brain of parkinsonian monkeys.
The effect of autologous transplantation of the superior cervical ganglion (SCG) into the brain of parkinsonian monkeys was studied through quantitative measurement of animal behavior. The motor activity of the monkey was measured with a telemetry system during the experiment. After experimental parkinsonism was induced by repeated intravenous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), three monkeys were treated with autologous transplantation of the SCG into both caudate nuclei. One monkey served as a control without SCG transplantation after MPTP treatment. Three SCG-transplanted monkeys showed biphasic (acute and chronic) behavioral amelioration of parkinsonism after transplantation. In the acute stage, the animals showed transient hyperkinesia with aggressive behavior and loss of circadian rhythm. In the chronic stage following acute hyperkinesia, the animals regained normal behavior and circadian rhythm without aggressiveness. In contrast with the transplanted monkeys, the control monkey failed to show recovery of the bradykinesia and muscle rigidity.
Nakai
M
M
Department of Neurological Surgery, Wakayama Medical College, Japan.
Itakura
T
T
Kamei
I
I
Nakai
K
K
Naka
Y
Y
Imai
H
H
Komai
N
N
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000601:surgery*; D005728:Ganglia, Sympathetic / Q000601:surgery*; D008251:Macaca; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000601:surgery*; D014182:Transplantation, Autologous
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine