title: Ibopamine in the treatment of mild chronic heart failure in elderly patients. A double-blind, placebo-controlled study.
abstract: This double-blind, randomized, multicenter clinical study assessed the efficacy and safety of ibopamine 100 mg t.i.d. as monotherapy vs. placebo in 52 patients with mild chronic heart failure aged over 60 years during a 12-week treatment period. Ibopamine produced a statistically significant increase in exercise tolerance and reduction in fatigue during effort compared to placebo. A trend towards decreased requirement of concomitant diuretic therapy was noted in the ibopamine-treated group. Ibopamine was well tolerated throughout the study. This study indicated that ibopamine is an effective and safe agent as monotherapy in the treatment of mild chronic heart failure in elderly patients.
authors.affiliation: Professorial Department of Medical Pathology, University of Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Azzolini
authors.forename: E
authors.initials: E
authors.lastname: Guffanti
authors.forename: M
authors.initials: M
authors.lastname: Ronzitti
authors.forename: L
authors.initials: L
authors.lastname: Tantalo
authors.forename: A
authors.initials: A
authors.lastname: Colantoni
authors.forename: C
authors.initials: C
authors.lastname: Pizzorni
mesh_terms: D000368:Aged; D002316:Cardiotonic Agents; D003846:Deoxyepinephrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D014665:Vasodilator Agents
chemical_list: D002316:Cardiotonic Agents; D014665:Vasodilator Agents; C023487:ibopamine; D003846:Deoxyepinephrine