Mutagenic effects of ferric nitrilotriacetate (Fe-NTA) on V79 Chinese hamster cells and its inhibitory effects on cell-cell communication.
Ferric nitrilotriacetate (Fe-NTA) induced dose- and time-dependent mutation of V79 Chinese hamster cells to 6-thioguanine resistance. It also caused dose-related inhibition of metabolic cooperation. However, no significant induction of chromosome aberrations was detected in cells treated with Fe-NTA up to 100 micrograms Fe/ml of the drug even after treatment for 3 days. Our results indicate that Fe-NTA has mutagenic effects on V79 cells and inhibitory effects on cell--cell communication, and these effects may contribute to NTA-Fe-induced neoplastic transformation of mammalian cells.
Nakatsuka
S
S
Department of Urology, Kawasaki Medical School, Okayama, Japan.
Tanaka
H
H
Namba
M
M
D000085:Acetates / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002450:Cell Communication / Q000187:drug effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds / Q000633:toxicity*; D005609:Free Radicals; D009153:Mutagens; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives / Q000633:toxicity*; D010100:Oxygen / Q000378:metabolism
D000085:Acetates; D002273:Carcinogens; D005290:Ferric Compounds; D005609:Free Radicals; D009153:Mutagens; D009571:Nitrilotriacetic Acid; D010100:Oxygen; C020326:ferric nitrilotriacetate