Effect of hydrophobic coating on the behavior of a hygroscopic aerosol powder in an environment of controlled temperature and relative humidity.
Powders of uncoated disodium fluorescein (DF) and DF coated with various amounts of lauric or capric acids were generated as aerosols in an environment of controlled temperature and relative humidity. The particle size and distribution of these powders were characterized using a cascade impactor and a computerized data inversion method of analysis. Disodium fluorescein exhibited a hygroscopic growth ratio of 1.5 at a relative humidity of 97%. This growth was reduced to 1.3 by coating with 0.15 g of lauric acid or 0.8 g of capric acid per gram of DF, and was eliminated with 0.2 g of lauric acid or 0.18 g of capric acid per gram of DF. The reduction in hygroscopic growth probably reflects an inhibition of the growth rate. In the time following generation and prior to deposition in the collection device, approximately 40 s, the coated aerosol powders do not seem to reach their equilibrium droplet diameter. These studies indicate that these combinations of DF and fatty acid would result in larger equilibrium droplet diameters than that of the dye alone.
Hickey
A J
AJ
University of Aston, Pharmaceutical Sciences Institute, Birmingham, U.K.
Gonda
I
I
Irwin
W J
WJ
Fildes
F J
FJ
D000336:Aerosols / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003652:Decanoic Acids / Q000737:chemistry; D019793:Fluorescein; D005452:Fluoresceins; D006813:Humidity; D007850:Lauric Acids / Q000737:chemistry; D009994:Osmolar Concentration; D010316:Particle Size; D011208:Powders / Q000737:chemistry*; D012995:Solubility; D013696:Temperature
D000336:Aerosols; D003652:Decanoic Acids; D005452:Fluoresceins; D007850:Lauric Acids; D011208:Powders; C030358:lauric acid; D019793:Fluorescein