[Solution of genetic problems of ecology using the automated system "Bioscreen C" (SOS-Chromotest program)].
Comparative experiments on the use of the automated system Bioscreen C (SOS-chromotest program) and the Eims tests for estimating the SOS-inducing and mutagenic activity of chemical compounds belonging to 5 different classes showed that the system was obviously promising and safe in rapid screening of environmental mutagens and carcinogens. Advantages of the system use as well as its prospects, specificity and limitations were revealed.
Vasil'eva
S V
SV
N. N. Semenov Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow.
Iskandarova
K A
KA
D001388:Aziridines / Q000633:toxicity; D002274:Carcinogens, Environmental / Q000633:toxicity*; D015386:Hazardous Substances / Q000633:toxicity*; D006861:Hydrogen Peroxide / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D011083:Polycyclic Compounds / Q000633:toxicity; D013014:SOS Response, Genetics / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000235:genetics; D012984:Software
D001388:Aziridines; D002274:Carcinogens, Environmental; D015386:Hazardous Substances; D011083:Polycyclic Compounds; D006861:Hydrogen Peroxide
Reshenie geneticheskikh problem ékologii s pomoshch'iu avtomatizirovannoĭ sistemy "Bioskrin C" (Programma "SOS-Khromotest").