Internal pressure of sealed containers during autoclaving.
The use of steam as a sterilizing media for rigid, fixed volume containers is routine. When applied to less rigorous packages this process can cause package failure and product contamination or loss. A study has been carried out verifying the validity of a previously developed equation by measuring the actual pressures generated during sterilization in a small container system.
Joyce
M A
MA
Sterling Research Group, Division of Sterling Drug, Rensselaer, New York.
Lorenz
J W
JW
D004349:Drug Packaging; D005240:Feasibility Studies; D006358:Hot Temperature; D008432:Mathematical Computing; D008962:Models, Theoretical; D011312:Pressure; D013242:Sterilization / Q000295:instrumentation*