title: Cocaine alters behavioral states in fetal sheep.
abstract: Intrauterine cocaine exposure causes subtle neurologic abnormalities in human newborn infants; however, the mechanism for these abnormalities is not known. To investigate whether cocaine alters fetal behavioral state, the electrocortical, electro-ocular and neck muscle electrical activity was monitored in 7 chronically instrumented fetal sheep before and during both saline and cocaine HCl infusions directly to the fetus. Saline infusion to the fetus had no effect on the percentage of time spent in rapid eye movement sleep compared to no infusion (37.5 +/- 11.6% vs 46.3 +/- 4.6%, mean +/- SD, P greater than 0.1). Cocaine infusion directly to the fetus had no effect on fetal arterial pO2, but did increase mean arterial pressure from 53.6 +/- 15 mmHg to 61.0 +/- 21 mmHg (P less than 0.01). In addition, during cocaine infusion, the percentage of time spent in rapid eye movement sleep dropped to 3.9 +/- 5.1% (P less than 0.0001) and the average duration of rapid eye movement epochs decreased from 10.1 +/- 3.0 min precocaine infusion to 1.9 +/- 2.6 min during cocaine infusion (P less than 0.02). The influence of cocaine was noted in a frequency analysis of the electrocorticogram. The amplitude of the energy centered at 1 Hz during cocaine infusion (73.8 +/- 4.0 dB) was greater than the amplitude during rapid eye movement sleep (65.5 +/- 4.7 dB) and less than the amplitude during non-rapid eye movement periods (79.9 +/- 4.5 dB) (P = 0.01). Cocaine appears to alter fetal behavioral state directly and this may play a role in the abnormal behavior in newborn infants exposed to cocaine in utero.
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville 32610.
authors.forename: D J
authors.initials: DJ
authors.lastname: Burchfield
authors.forename: E M
authors.initials: EM
authors.lastname: Graham
authors.forename: R M
authors.initials: RM
authors.lastname: Abrams
authors.forename: K J
authors.initials: KJ
authors.lastname: Gerhardt
mesh_terms: D000818:Animals; D003042:Cocaine / Q000633:toxicity*; D004576:Electromyography / Q000187:drug effects; D004585:Electrooculography / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D007263:Infusions, Parenteral; D012756:Sheep; D012895:Sleep, REM / Q000187:drug effects*
chemical_list: D003042:Cocaine