Malondialdehyde affects the physico-chemical and biological characteristics of oxidized low density lipoprotein.
Oxidized LDL (Ox-LDL) was found in the atherosclerotic lesion and was associated with the formation of foam cells. Ox-LDL (30 micrograms protein/ml) reduced collagen induced platelet aggregation by 18% but following dialysis, this lipoprotein enhanced platelet aggregation by 21% in platelet-rich plasma. The addition of malondialdehyde to the dialyzed Ox-LDL prevented its stimulatory activity. Enhanced macrophage uptake of Ox-LDL however, was not affected by dialysis. Thus it is important to use similar preparations of Ox-LDL when comparing results with these lipoproteins.
Aviram
M
M
Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel.
D002784:Cholesterol / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D003956:Dialysis; D004586:Electrophoresis; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010974:Platelet Aggregation / Q000187:drug effects
D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D003094:Collagen; D002784:Cholesterol