Treatment of experimental chronic osteomyelitis due to Staphylococcus aureus with ampicillin/sulbactam.
Ampicillin/sulbactam was used for the treatment of experimental osteomyelitis due to Staphylococcus aureus in rabbits. Treatment with 200 mg/kg (ampicillin) three times a day sterilized 40% of infected rabbit bones. The results of 4 weeks of treatment with ampicillin/sulbactam for chronic experimental staphylococcal osteomyelitis were comparable to those obtained previously with cephalothin and with oxacillin in previous studies and were not as good as those with clindamycin alone or combination therapy that included rifampin.
Norden
C W
CW
Department of Medicine, Montefiore Hospital, University of Pittsburgh School of Medicine, Pennsylvania.
Budinsky
A
A
D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008826:Microbial Sensitivity Tests; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits; D012976:Sodium Morrhuate; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013407:Sulbactam / Q000627:therapeutic use*
D000667:Ampicillin; D012976:Sodium Morrhuate; D013407:Sulbactam