title: Direct comparison of cognitive facilitation by physostigmine and tetrahydroaminoacridine in two primate models.
abstract: Cognitive facilitation by physostigmine and tetrahydroaminoacridine (THA) was compared in two primate models. Disruption of spatial delayed response performance by scopolamine (0.03 mg/kg) was fully reversed by coadministration of 5 doses of physostigmine in the range 0.03-0.08 mg/kg, but by only one dose (4.0 mg/kg) of THA; partial reversal of some effects of scopolamine was observed at 1 and 3 mg/kg of THA. Visual recognition memory was enhanced following treatment with 4 doses of physostigmine in the range 0.001-0.03 mg/kg. The effect of THA across the group of animals was not significant but performance tended to improve using a dose of 0.8 mg/kg. Our findings indicate that THA does not have a superior profile to physostigmine as a cognitive enhancer in primates.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K.
authors.forename: N M
authors.initials: NM
authors.lastname: Rupniak
authors.forename: M J
authors.initials: MJ
authors.lastname: Field
authors.forename: N A
authors.initials: NA
authors.lastname: Samson
authors.forename: M J
authors.initials: MJ
authors.lastname: Steventon
authors.forename: S D
authors.initials: SD
authors.lastname: Iversen
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects; D013268:Stimulation, Chemical; D013619:Tacrine / Q000494:pharmacology*; D014785:Vision, Ocular / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D013619:Tacrine; D010830:Physostigmine