title: [Pulmonary transfer factor for carbon monoxide (TLco) in healthy children and in children with chronic lung diseases, measured with an improved rebreathing technique].
abstract: TLco, FRC-He and IVC were tested in 86 subjects (5-29 years). 46 children were healthy, 21 patients had cystic fibrosis, 13 bronchial asthma and 6 allergic alveolitis. The test gas included 14% helium and 0.3% CO. The wash in time was 18 s, the measuring time 20 s. All children were measured at rest and in a sitting position. The rebreathing volume was 3/4 of the VC plus 300 ml additional volume. The results showed a good reproducibility. The TLco increases with age, height, weight and body surface area, the correlation with VC, FRC and TLC was better. A differentiation between healthy children and patients suffering from lung disease is possible. The clearest results were shown in the case of patients suffering from CF.
authors.affiliation: Klinik für Kinder und Jugendliche der Universität Erlangen-Nürnberg.
authors.forename: U
authors.initials: U
authors.lastname: Friedrich
authors.forename: J
authors.initials: J
authors.lastname: Schuster
authors.forename: T
authors.initials: T
authors.lastname: Zimmermann
mesh_terms: D001249:Asthma / Q000503:physiopathology; D002248:Carbon Monoxide / Q000378:metabolism*; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology; D006801:Humans; D011653:Pulmonary Diffusing Capacity; D012129:Respiratory Function Tests / Q000379:methods*; D012140:Respiratory Tract Diseases / Q000503:physiopathology*
chemical_list: D002248:Carbon Monoxide
vernacular_title: Der Transferfaktor der Lunge für Kohlenmonoxid (TLco) bei gesunden und bei chronisch lungenkranken Kindern, gemessen mit einer verbesserten Rückatemmethode.