CD45RA is detected in all thymocyte subsets defined by CD4 and CD8 by using three-colour flow cytometry.
In the mouse, using three-colour flow cytometry, the presence of CD45RA+ cells is demonstrated amongst all of the thymocyte subsets defined by expression of CD4 and CD8, i.e. amongst the double negatives, immature CD8 single positives, double-positive blasts and CD4 and CD8 single positives. This evidence is compatible with the existence of a continuous lineage of T cells expressing CD45RA which would develop from double-negative to mature single-positive T cells.
Lightstone
E B
EB
ICRF Tumour Immunology Unit, University College London.
Marvel
J
J
D000375:Aging / Q000276:immunology; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D015704:CD4 Antigens / Q000276:immunology*; D003116:Color; D005260:Female; D005434:Flow Cytometry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens