title: [Primary gastric lymphoma: incidence, prognostic factors and effect of treatment with chemotherapy].
abstract: This paper deals with the prevalence, clinical features and therapeutic response of 19 patients with primary gastric lymphoma studied and treated at Centro de Hematologia y Medicina Interna de Puebla, Mexico and Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City, Mexico, in a 10 year period (1979-1989). The main findings were as follows: 1) The prevalence of gastric lymphoma has increased in Mexico: Between 1950 and 1980 the prevalence was found at 4.5% of all gastric tumors, whereas between 1980 and 1990 it was found at the 7.6% level (chi square = .0001). 2) The significant prognostic factors for survival were in this series the clinico-pathologic stage and the degree of infiltration of the gastric wall: 80-month disease free survival was 80% and 44% respectively for stages I and III (p less than 0.02); 10-year disease free survival was 100% and 23% respectively for mucosal/submucosal infiltration VS mucosal/serosal infiltration (p less than 0.01). 3) The 10-year disease free survival was 68% for patients treated with chemotherapy and surgery; this figure is similar to those obtained using radiotherapy and surgery, but with a lower relapse rate. Two patients with lymphomatous lesion less than 3 cm. and invading only mucosae/submucosae were treated solely with chemotherapy and both of them remain disease free after 20 months of follow-up.
authors.affiliation: Centro de Hematología y Medicina Interna de Puebla, México.
authors.forename: E
authors.initials: E
authors.lastname: Lobato-Mendizábal
authors.forename: G J
authors.initials: GJ
authors.lastname: Ruiz Argüelles
authors.forename: R
authors.initials: R
authors.lastname: Labardini-Méndez
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Mejorada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005743:Gastrectomy; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D008800:Mexico / Q000453:epidemiology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D015996:Survival Rate
vernacular_title: Linfoma gástrico primario: incidencia, factores pronósticos y efecto del tratamiento con quimioterapia.