[The parenchymatous-stromal interrelationships in adenocarcinomas of the large intestine (an electron radioautographic study)].
Parenchymatous and stromal cells in colonic adenocarcinomas were studied electron-radiographically. The properties of the nucleic acid and protein synthesis in the cylindrical and goblet cells in carcinoma (partial 3H-thymidine incorporation, heterogeneity of 3H-uridine and amino acid mixture incorporation) indicate a relatively low level of their differentiation, lower degree of their participation in a specific function, retaining their capacity to proliferate. A high number of 3H-thymidine-labelled stem cells which are the main source of tumour growth is observed in carcinoma. Stroma in carcinoma is characterized by endotheliocyte and fibroblast proliferation (3H-thymidine incorporation), high degree of metabolic processes in some of these cells (3H-uridine and amino acid mixture incorporation) and by the disturbance of immunocompetent cell specific function (partial and weak labelling of the immunocompetent cells with 3H-uridine and amino acid mixture).
Gvamichava
T A
TA
Gabuniia
U A
UA
Sulava
L M
LM
D000230:Adenocarcinoma / Q000378:metabolism / Q000648:ultrastructure*; D001345:Autoradiography / Q000379:methods; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D007420:Intestine, Large / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron / Q000379:methods; D012334:RNA, Neoplasm / Q000378:metabolism
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm
Parenkhimatozno-stromal'nye vzaimootnosheniia v adenokartsinomakh tolstoĭ kishki (élektronno-radioavtograficheskoe issledovanie).