Increase in the acute toxicity and brain concentrations of chlorophenoxyacetic acids by probenecid in rats.
1. Probenecid increased the acute toxicity of chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA) in rats. 2. Probenecid increased the brain to plasma ratios of all the three 14C-labelled chlorophenoxyacetic acids. The increase was due only partly to the displacement of chlorophenoxyacids from their binding sites in rat plasma proteins by probenecid. 3. Probenecid did not change significantly the intracerebral distribution pattern of 14C-labelled chlorophenoxyacetic acids.
Ylitalo
P
P
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Närhi
U
U
Elo
H A
HA
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000378:metabolism / Q000633:toxicity; D015084:2,4-Dichlorophenoxyacetic Acid / Q000378:metabolism / Q000633:toxicity; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D011339:Probenecid