A new diagnostic approach to the Dubin-Johnson syndrome.
Dubin-Johnson syndrome (DJS), a congenital metabolic disorder of bilirubin excretion, was classically diagnosed by the bromsulfalein (BSP) curve and needle hepatic biopsy methods. We present three cases of DJS and propose a new diagnostic approach which could conceivably become a substitute for more aggressive techniques. The results of the 24-h urine coproporphyrin determination and 99mTc-Disofenin scintigraphy gave, together, enough data for an accurate diagnosis.
Pinós
T
T
Department of Gastroenterology, Quinta de Salud La Aliança, Sabadell, Spain.
Constansa
J M
JM
Palacin
A
A
Figueras
C
C
D000328:Adult; D003306:Coproporphyrins / Q000652:urine; D006801:Humans; D007098:Imino Acids; D007566:Jaundice, Chronic Idiopathic / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D019785:Technetium Tc 99m Disofenin
D003306:Coproporphyrins; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019785:Technetium Tc 99m Disofenin