PNA: a marker of neoplastic progression and differentiation in the gastro-intestinal tract.
We examined 35 cases of stomach carcinoma and 40 cases of colonic carcinoma with PNA associated with peroxidase (peanut agglutinin, lectin which binds to the terminal disaccharide galactose beta (1,3)-N-acetil-galacto-samine). In this way evaluation of the functional aspects of the normal-neoplastic sequence was undertaken. This method was carried out for histological and ultrastructural investigations. The results obtained in both cases showed a different reactivity in the evolution of neoplastic disease: in fact, positivity in dysplasia is finely granular intracytoplasmic, whereas in well-differentiated neoplastic transformation such a reactivity is preferentially localized along the cellular membranes, with restoration of gross positivity in the cytoplasm for the poorly-differentiated neoplasm. We therefore believe PNA to be a marker not only of neoplastic progression but of differentiation as well: we also hypothesize it to reveal glycoprotein groups with possible antigenic power, involved in immunologic interactions between tumor and host.
Grigolato
P
P
Institute of Anatomy and Histological Pathology, University of Brescia, Italy.
Benetti
A
A
Berenzi
A
A
Villanacci
V
V
Tardanico
R
R
D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000473:pathology; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology; D037102:Lectins; D019887:Peanut Agglutinin; D011975:Receptors, Mitogen / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology
D014408:Biomarkers, Tumor; D037102:Lectins; D019887:Peanut Agglutinin; D011975:Receptors, Mitogen; C038223:peanut agglutinin receptor