Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. I. Genetic and cellular effects.
The cellular effects of the antioxidants butylated hydroxyanisole and butylated hydroxytoluene were studied in a battery of in vitro tests. No evidence of genotoxicity was obtained for either compound in the hepatocyte primary culture/DNA repair test, the Salmonella/microsome mutagenesis test, the adult rat liver epithelial cell/hypoxanthine guanine phosphoribosyl transferase test, or for butylated hydroxyanisole in the Chinese hamster ovary cell/sister chromatid exchange test. Both compounds inhibited intercellular molecular exchange between cultured liver cells, an effect that has been observed for many agents with neoplasm-promoting activity.
Williams
G M
GM
American Health Foundation, Valhalla, NY 10595.
McQueen
C A
CA
Tong
C
C
D000818:Animals; D002083:Butylated Hydroxyanisole / Q000633:toxicity*; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects*; D008297:Male; D009152:Mutagenicity Tests; D009154:Mutation; D051381:Rats; D011916:Rats, Inbred F344; D012854:Sister Chromatid Exchange / Q000187:drug effects
D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole