A versatile, highly reactive, cross-linking reagent: 2,2'-sulfonylbis[3-methoxy-(E,E)-2-propenenitrile].
Adequate aqueous stability and cross-linking ability of the novel title reagent, recently discovered in this laboratory, have been demonstrated by comparison of its rate of hydrolysis with the rate of reaction with an amine nucleophile and by cross-linking deoxy- and oxyhemoglobins, as an example.
Hosmane
R S
RS
Department of Chemistry and Biochemistry, University of Maryland, Baltimore County 21228.
Bertha
C M
CM
D000588:Amines; D003432:Cross-Linking Reagents; D006454:Hemoglobins; D006868:Hydrolysis; D009570:Nitriles; D013450:Sulfones; D014867:Water
D000588:Amines; D003432:Cross-Linking Reagents; D006454:Hemoglobins; D009570:Nitriles; D013450:Sulfones; D014867:Water; C062628:2,2'-sulfonylbis(3-methoxy-2-propenenitrile)