title: Effects of combinations of arecoline and atropine on mouse motor activity.
abstract: 1. Effects on motor activity were studied after acute administration of arecoline, atropine alone and in combination in the mouse. 2. Atropine from 15 to 45 mg/kg increased motor activity. 3. A reduction in activity was observed at doses of arecoline above 0.2 mg/kg. 4. An antagonism between arecoline and atropine was observed only at low doses of arecoline, while higher doses of arecoline in association with atropine increased activity.
authors.affiliation: Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Turin, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Cassone
authors.forename: L
authors.initials: L
authors.lastname: Molinengo
authors.forename: M
authors.initials: M
authors.lastname: Orsetti
mesh_terms: D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology*; D004347:Drug Interactions; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D012016:Reference Values
chemical_list: D001115:Arecoline; D001285:Atropine