Reduced toxicity of adriamycin by incorporation into ion exchange microspheres: a therapeutic study using a rat liver tumour model.
A comparison of the systemic toxicity and therapeutic efficacy of adriamycin carrying microspheres with conventional chemotherapeutic use of adriamycin was performed using a rat liver tumour model. The drug-microspheres were administered via the gastro-duodenal artery for delivery to the liver, whilst similar quantities of free adriamycin were given by systemic intravenous or regional intra-arterial routes. Significant leukopenia, thrombocytopenia and mortality were observed in the systemically treated free drug group (P less than 0.05) with a similar trend for for myelosuppression occurring in the intra-arterial free drug group. The adriamycin-microsphere group showed no toxic side-effects despite retarding tumour growth by similar amounts to the other drug modalities. This work demonstrates a large potential for the use of adriamycin carrying ion-exchange microspheres in the treatment of human malignancy.
Codde
J P
JP
University Department of Surgery, Royal Perth Hospital, Western Australia.
Burton
M A
MA
Kelleher
D K
DK
Archer
S G
SG
Gray
B N
BN
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D004337:Drug Carriers; D007958:Leukocyte Count / Q000187:drug effects; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains
D004337:Drug Carriers; D004317:Doxorubicin