title: Clinical features and treatment outcome of patients with epithelial carcinoma of the ovary metastatic to the central nervous system.
abstract: Involvement of the central nervous system with carcinoma of the ovary is being noted with increasing frequency. We report on six patients who presented with central nervous system metastases between 2-61 months after diagnosis. Five patients had elevated serum CA 125 values at the time of diagnosis of central nervous system disease and presenting symptoms, and findings on neurologic examination generally correlated with computed tomography-documented lesions. Eighty-three percent of our patients were symptomatically relieved with a course of 30 Gy given to the whole brain; however, there were no long-term survivors (range 2-24 months). Survival did not appear prolonged in the four patients who received systemic chemotherapy as well as whole-brain irradiation.
authors.affiliation: Division of Gynecologic Oncology, University of California, San Diego.
authors.forename: S C
authors.initials: SC
authors.lastname: Plaxe
authors.forename: P R
authors.initials: PR
authors.lastname: Dottino
authors.forename: R
authors.initials: R
authors.lastname: Lipsztein
authors.forename: J
authors.initials: J
authors.lastname: Dalton
authors.forename: C J
authors.initials: CJ
authors.lastname: Cohen
mesh_terms: D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008577:Meningeal Neoplasms / Q000556:secondary; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000628:therapy*; D011379:Prognosis; D014057:Tomography, X-Ray Computed
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate