title: [Pyridoxine-dependent seizures. Remarks on clinical variability and pathogenesis].
abstract: The clinical variability of pyridoxine dependent seizures is greater than mentioned in most textbooks. The seizures can start during the first days of life, or later during the first year. Frequently they are therapy-resistant, but seizure free periods of several weeks duration can be achieved with anticonvulsants in some patients. The response to the injection of pyridoxine can be delayed. A trial with daily oral administration of pyridoxine is often more suitable than a single injection.
authors.affiliation: Kinderklinik, Fakultät für Klinische Medizin Mannheim der Universität, Heidelberg.
authors.forename: R
authors.initials: R
authors.lastname: Korinthenberg
authors.forename: C
authors.initials: C
authors.lastname: Schultze
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage; D004569:Electroencephalography / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage; D013036:Spasms, Infantile / Q000188:drug therapy / Q000235:genetics*; D026681:Vitamin B 6 Deficiency / Q000235:genetics*; D005680:gamma-Aminobutyric Acid / Q000172:deficiency
chemical_list: D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; D011736:Pyridoxine
vernacular_title: Pyridoxinabhängige Krampfanfälle. Bemerkungen zur klinischen Variabilität und pathogenese.