The effects of propranolol or atenolol on the cardiovascular responses to central hypovolaemia in Europeans and Bengalees.
1. The effects of single oral doses of propranolol (80 mg), or atenolol (100 mg) on resting heart rate, blood pressure, forearm blood flow and forearm vascular resistance and on responses to central hypovolaemia, were compared with those of placebo in nine healthy European and nine healthy Bengalee volunteers, in a double-blind, three-period, cross-over study. 2. Atenolol induced a significant reduction in resting systolic blood pressure (SBP) in Europeans but not in Bengalees, although the bradycardic effects of atenolol were similar in both groups. Atenolol did not have any significant effect on forearm blood flow (FBF) or forearm vascular resistance (FVR) in either group. In the presence of propranolol (80 mg) there were no statistically significant falls in BP but there were significant bradycardias, falls in FBF and rises in FVR that were similar in Europeans and Bengalees. 3. In the presence of placebo Europeans exhibited significant falls in diastolic blood pressure (DBP) during lower body negative pressure (LBNP) of 20 and 30 mm Hg. Bengalees did not show falls in DBP during LBNP. However, there were no significant differences between DBP responses in Europeans and Bengalee subjects. Both Bengalees and European subjects showed similar reductions in FBF and FVR during LBNP of 30 mm Hg. 4. In the presence of propranolol, significant changes in forearm blood flow and forearm vascular resistance were evident in Bengalee subjects during LBNP of 20 mm Hg and 30 mm Hg, whereas in the Europeans significant changes in those variables did not occur at any level. The changes in FBF and FVR during LBNP of 20 and 30 mm Hg in Bengalee and European subjects were significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
Rahman
M A
MA
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, University of Nottingham.
Bennett
T
T
D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D004311:Double-Blind Method; D004562:Electrocardiography; D005006:Ethnicity; D005060:Europe; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007194:India; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D001262:Atenolol; D011433:Propranolol