Effect of cyclosporin-A, antimalarial drug, on lymphocyte proliferation of Balb/c mice in vitro.
Cyclosporin-A(CsA) caused inhibition of lymphocyte proliferation at higher doses (5 and 10 micrograms/ml) compared to controls. When spleen cells were preincubated with high doses of CsA and washed, the normal lymphocyte response to stimulation with mitogen (concanavalin-A) and lymphokine (interleukin-2) was not affected. The results indicate that CsA's suppressive effect at higher doses, was a temporary one and potential use of CsA to control parasitic infections should be examined.
Upender
M
M
Immunology Lab, Malaria Research Centre (ICMR), Delhi, India.
Saxena
Q B
QB
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology
D003524:Cyclosporins; D007376:Interleukin-2; D003208:Concanavalin A