title: Development of enolase isoenzymes in various regions of the human brain.
abstract: Various brain regions from 4 fetuses (21st to 28th gestational week) and from a 3-month-old infant were investigated for the total enolase activity and their isoenzyme distribution. In the brain tissue from a 3-month-old infant, the activity of the so-called neuron-specific enolase amounted to about 50% of the total enolase activity. In various brain regions different developmental patterns emerged for nonneuronal (NNE) and neuron-specific enolase (NSE). By the 21st gestational week the medulla, pons and thalamus had already reached a relatively high NSE activity (about 60-90% of that of the 3-month values), whereas the cortex regions had 10-30% only. It is concluded that in phylogenetically old regions, the switch from NNE to NSE-subunits appears before the 21st gestational week, in the phylogenetically young regions between the 21st and 28th gestational week.
authors.affiliation: Institute of Pathological and Clinical Biochemistry, Humboldt University, Charité Hospital, Berlin, GDR.
authors.forename: J
authors.initials: J
authors.lastname: Gross
authors.forename: J
authors.initials: J
authors.lastname: Zinsmeyer
authors.forename: A
authors.initials: A
authors.lastname: Lessing
authors.forename: J
authors.initials: J
authors.lastname: Wenzel
authors.forename: P
authors.initials: P
authors.lastname: Prenzlau
authors.forename: H
authors.initials: H
authors.lastname: Halle
authors.forename: E L
authors.initials: EL
authors.lastname: Grauel
mesh_terms: D001921:Brain / Q000196:embryology / Q000201:enzymology*; D005333:Fetus; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D010751:Phosphopyruvate Hydratase