title: [Comparison of the protective effects on the erythrocytes of ceruloplasmin from the blood of healthy donors and patients with hepatocerebral dystrophy].
abstract: The binding of the ceruloplasmin (CP) from the healthy donor's blood and of ceruloplasmin--like protein (p-CP) isolated from the Wilson disease patient's blood with erythrocytes (RBC) of healthy donors and with RBC of Wilson's patients (p-RBC) was investigated. It was shown, that the CP number of binding sites both on the RBC and p-RBC was significantly lower than that for p-CP, but Kd value for p-CP binding of the both types of erythrocytes was approximately 10 times higher than Kd value for CP. The protective action of CP on copper stimulated hemolysis is almost 3 times higher than that of p-CP. The protective action of CP on ferrous ion stimulated hemolysis doesn't correlate with its ferroxidase activity. On the contrary the protective effect of p-CP which has no ferroxidase activity is more powerful than that of CP.
authors.forename: E L
authors.initials: EL
authors.lastname: Saenko
authors.forename: O V
authors.initials: OV
authors.lastname: Skorobagat'ko
authors.forename: A I
authors.initials: AI
authors.lastname: Iaropolov
mesh_terms: D001665:Binding Sites; D001782:Blood Donors; D002570:Ceruloplasmin / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006461:Hemolysis; D006527:Hepatolenticular Degeneration / Q000097:blood*; D006801:Humans; D011485:Protein Binding
chemical_list: D002570:Ceruloplasmin
vernacular_title: Sravnenie zashchitnogo deĭstviia, okazyvaemogo na éritrotsity tseruloplazminom iz krovi zdorovykh donorov i bol'nykh gepatotserebral'noĭ distrofieĭ.