[What do we know about lipoproteins containing apo A-I?].
Since the Alaupovic's original concept, the lipoproteins were more and more classified according to their biochemical composition. Between the different and well identified lipoproteins particles, those containing apo A-I were particularly studied. These particles had a very great heterogeneity with respect to both their physicochemical properties and their apolipoproteins composition especially if they had or not the apo A-II. This criterion was frequently used for their classification in two different populations: the lipoproteins which contained both apo A-I and apo A-II (Lp A-I:A-II) and the other lipoproteins which contained apo A-I but no apo A-II (Lp A-I). All the two lipoprotein populations could be divided in several subpopulations. Among the two categories of lipoprotein particles, those devoid of apo A-II were described as the actual anti-atherogenic ones. Indeed, the Lp A-I population appeared as the only lipoproteins which decreased in serum during an atherosclerotic affection, this phenomenon being related to the favourable role of the Lp A-I population in the normal metabolism of lipids. Only the Lp A-I were demonstrated be able to induce and enhance the cholesterol efflux from culture cells. The Lp A-I:A-II function remained unknown, but the hypothesis is raised of a possible regulatory role which could be related to the high concentration of LpA-I in the cholesterol reverse transport.
Barkia
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Institut National de Nutrition et de Technologies Alimentaires, Bab Saâdoun, Tunis, Tunisie.
D000328:Adult; D000367:Age Factors; D001054:Apolipoproteins A / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology; D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology; D002846:Chromatography, Affinity; D002852:Chromatography, Ion Exchange; D006801:Humans; D007231:Infant, Newborn
D001054:Apolipoproteins A
Que savons-nous des lipoprotéines contenant l'apo A-I?