Transient glomerulonephropathy associated with primary erythrocytosis in a dog.
Proteinuria (urine protein/creatinine ratio, 13.6) resolved after control of primary erythrocytosis in a dog. Hydroxyurea and doxorubicin administration and phlebotomy were used initially to manage erythrocytosis. Remission was maintained for approximately 2 years. Glomerulonephropathy, characterized by absence of routine histologic or immunofluorescent changes and ultrastructural evidence of basement membrane deterioration and podocyte fusion, was documented. These lesions may have been a result of hypoxia and/or hyperviscosity secondary to erythrocytosis.
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Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Stiff
M E
ME
McEntee
M C
MC
Walter
L G
LG
D000818:Animals; D001815:Bloodletting; D003131:Combined Modality Therapy; D004283:Dog Diseases / Q000209:etiology* / Q000628:therapy; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006918:Hydroxyurea / Q000627:therapeutic use; D007674:Kidney Diseases / Q000209:etiology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D011086:Polycythemia / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D011507:Proteinuria / Q000209:etiology / Q000662:veterinary*
D004317:Doxorubicin; D006918:Hydroxyurea