Acute coronary events following cisplatin-based chemotherapy.
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy. In two patients this was the sole chemotherapeutic agent used. One patient underwent coronary angiography which disclosed no pathology, but following which, while on a calcium channel blocking agent regimen, he had an uneventful course of chemotherapy with cisplatin. Documentation of cisplatin-related vascular events is important in view of the growing number of patients who undergo cisplatin-based chemotherapy.
Berliner
S
S
Department of Internal Medicine, Beilinson Medical Center, Petah Tikva, Israel.
Rahima
M
M
Sidi
Y
Y
Teplitsky
Y
Y
Zohar
Y
Y
Nussbaum
B
B
Pinkhas
J
J
D000368:Aged; D002945:Cisplatin / Q000009:adverse effects*; D003327:Coronary Disease / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D012907:Smoking
D002945:Cisplatin