[Flow cytometry results in patients with ulcerative colitis and Barrett esophagus. An additional diagnostic tool in the early diagnosis of a malignant transformation?].
In this review the basic principles of flow cytometry for the measurement of DNA content are described. In addition to cell cycle phase distributions DNA ploidy can be analysed by flow cytometry. Flow cytometric results in patients with ulcerative colitis and Barrett's esophagus seem to indicate that besides histologic examinations flow cytometry may play a role in surveillance programs of patients with an increased risk of a malignant transformation. These first interesting results, however, have still to be confirmed in long term studies.
Porschen
R
R
Abteilung für Gastroenterologie, Heinrich-Heine-Universität Düsseldorf.
Hengels
K J
KJ
D001471:Barrett Esophagus / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D003093:Colitis, Ulcerative / Q000473:pathology*; D004247:DNA / Q000032:analysis / Q000235:genetics; D005434:Flow Cytometry; D006801:Humans; D008938:Mitosis; D011003:Ploidies
D004247:DNA
Durchflusszytometrische Befunde bei Patienten mit Colitis ulcerosa und Barrett-Osophagus. Ein zusätzliches diagnostisches Hilfsmittel zur Früherkennung einer malignen Transformation?