Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes.
Guided by cytotoxicity, ansamitocin P-3, a maytansinoid, was isolated in very low yield from two members of the moss family Thuidiaceae, Claopodium crispifolium (Hook.) Ren. & Card. and Anomodon attenuatus (Hedw.) Hueb. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. A possible basis for the occurrence of this compound in mosses is discussed.
Suwanborirux
K
K
Department of Medicinal Chemistry, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Chang
C J
CJ
Spjut
R W
RW
Cassady
J M
JM
D000192:Actinomycetales / Q000032:analysis*; D000903:Antibiotics, Antineoplastic; D001943:Breast Neoplasms / Q000188:drug therapy; D002845:Chromatography; D003110:Colonic Neoplasms / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008453:Maytansine / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000627:therapeutic use; D015394:Molecular Structure; D010078:Oxazines / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D010078:Oxazines; D008453:Maytansine; C015682:ansamitocins