title: Hairy cell leukemia in two siblings. A human leukocyte antigen-linked disease?
abstract: Shared haplotypes have been documented in three of the four previously reported families with familial hairy cell leukemia (HCL). Human leukocyte antigen (HLA) typing was done on a four-member sibship in which two siblings had hairy cell leukemia. The two affected siblings share the haplotype A2; Bw6, Bw62(15); Cw1; DR4, DRw53; DQw3. No one HLA antigen or haplotype is common among the five families reported at this time. These limited data suggest HCL is not associated with a specific HLA antigen. HLA typing of a larger collection of cases of familial HCL may help better define what role, if any, inheritance plays in the occurrence of this rare disorder among numerous first degree relatives.
authors.affiliation: Department of Pathology, Walter Reed Army Medical Center, Washington, DC 20037-5001.
authors.forename: F T
authors.initials: FT
authors.lastname: Ward
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: J
authors.initials: J
authors.lastname: Krishnan
authors.forename: N
authors.initials: N
authors.lastname: Dow
authors.forename: C H
authors.initials: CH
authors.lastname: Kjobech
mesh_terms: D000368:Aged; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D006680:HLA Antigens