FMRF-NH2-like mammalian octapeptide: possible role in opiate dependence and abstinence.
Yang et al. have isolated from bovine brain an octapeptide, FLFQPQRF-NH2 (F-8-F-NH2), with certain antiopiate properties. Malin et al. previously found that ICV injection of this peptide could precipitate an opiate abstinence syndrome in dependent rats. RIA revealed significantly higher levels of F-8-F-NH2 immunoreactivity in CSF withdrawn from the cisterna magna of morphine-dependent rats as opposed to CSF withdrawn from sham-implanted controls. ICV infusion of IgG from antiserum against F-8-F-NH2 significantly reduced the number of abstinence signs subsequently precipitated by naloxone in morphine-dependent rats.
Malin
D H
DH
University of Houston-Clear Lake, TX 77058.
Lake
J R
JR
Hammond
M V
MV
Fowler
D E
DE
Rogillio
R B
RB
Brown
S L
SL
Sims
J L
JL
Leecraft
B M
BM
Yang
H Y
HY
D000818:Animals; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D009020:Morphine / Q000633:toxicity; D009021:Morphine Dependence / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000276:immunology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000737:chemistry; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control
D007074:Immunoglobulin G; D009842:Oligopeptides; D009270:Naloxone; D009020:Morphine; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide