Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy.
A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) with four cytogenetically different cell clones (49,XX,+5,+19,+21/47,XX,+X/46,XX,inv (14)(q11q32)/45,X,-X) is reported. To our knowledge, this is the first case of AILD with an inv(14)(q11q32), thus probably involving the T-cell receptor alpha-chain gene. The cytogenetic findings are discussed with respect to the possible progression of AILD to malignant lymphoma.
Schlegelberger
B
B
Department of Human Genetics, Christian Albrecht University, Kiel, Federal Republic of Germany.
Feller
A
A
Himmler
A
A
Grote
W
W
D002871:Chromosome Banding; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D008198:Lymph Nodes / Q000648:ultrastructure; D008875:Middle Aged