title: The association of hepatitis delta virus and hepatitis B virus in parenteral drug abusers. 1971 to 1972 and 1986 to 1987.
abstract: From 1971 to 1972 (N = 105) and 1986 to 1987 (N = 160), parenteral drug abusers seropositive for hepatitis B virus (HBV) markers were screened for antibodies to the hepatitis delta virus (anti-HD). In both time frames anti-HD was independently associated with the hepatitis B surface antigen. It was observed that 31% of those positive for hepatitis B surface antigen from the early sample and 20% of those from the latter sample had detectable anti-HD, as opposed to 10% and 7%, respectively, of those negative for hepatitis B surface antigen. Anti-HD seropositivity was unrelated to gender and ethnicity, and in the 1971 and 1972 nationwide sample, its presence was unrelated to geographic location. The probability of manifesting anti-HD increased with the more HBV markers detected, particularly the number of different HBV antibody markers. We conclude that anti-HD was wide-spread in parenteral drug abusers at least as early as 1971, and that its expression was associated with hepatitis B surface antigen and the intensity of the immune response to HBV as evidenced by the number of different circulating HBV antibodies.
authors.affiliation: Addiction Research Center, National Institute on Drug Abuse, Baltimore, Md.
authors.forename: W R
authors.initials: WR
authors.lastname: Lange
authors.forename: E J
authors.initials: EJ
authors.lastname: Cone
authors.forename: F R
authors.initials: FR
authors.lastname: Snyder
mesh_terms: D000293:Adolescent; D000328:Adult; D006508:Hepatitis Antibodies / Q000032:analysis; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000032:analysis; D003699:Hepatitis D / Q000453:epidemiology* / Q000276:immunology; D003698:Hepatitis Delta Virus / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000150:complications*; D014481:United States / Q000453:epidemiology
chemical_list: D006508:Hepatitis Antibodies; D006511:Hepatitis B Antigens