title: [Incidence and characterization of erythrocyte antibodies in a hospital blood bank. Study over a period of 9 years (1980-1988)].
abstract: Serological studies done in 21,124 patients receiving blood transfusions and in 85,202 units of blood, during a period of 9 years in a 750-bed University Hospital, are presented. 311 out of 21,124 blood transfusion recipients developed warm type alloantibodies, equivalent to an 1.4% incidence. 178 out of 85,202 blood units were found positive for the same kind of antibodies, thus giving a frequency of 0.2%. The most common warm alloantibodies were: anti-Rho (D) alone or in combination, 54%; anti-K 20%, anti-rh" (E) 14% and anti-Fya 5.3%. Warm alloantibodies occurred more frequently in patients that in donors, and more in women that in men, as already reported from other laboratories. Cold alloantibodies were detected in 0.83% of transfused patients and 0.19% of blood units. Their specificities were: anti-P1 44%, anti-Leb 16.2%, anti-Lea 5.9% and anti-M 3.5%. Cold alloantibodies appeared with the same frequency in patients as in donors, and more often in women that in men. 38.5% of all the antibodies found were autoanti-I or cold non-specific; they occurred much more frequently in patients, without any significant difference between both sexes.
authors.affiliation: Fundación Jiménez Díaz, Clínica de Ntra. Sra. de la Concepción, Ciudad Universitaria, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Serrano
mesh_terms: D000373:Agglutinins / Q000032:analysis; D000743:Anemia, Hemolytic / Q000209:etiology; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D001771:Blood Banks / Q000592:standards; D001789:Blood Group Antigens / Q000276:immunology; D001787:Blood Group Incompatibility / Q000453:epidemiology* / Q000276:immunology; D015331:Cohort Studies; D003450:Cryoglobulins; D005260:Female; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D013030:Spain / Q000453:epidemiology; D065227:Transfusion Reaction
chemical_list: D000373:Agglutinins; D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D001789:Blood Group Antigens; D003450:Cryoglobulins; D007518:Isoantibodies; C029443:cold agglutinins
vernacular_title: Incidencia y caracterización de anticuerpos eritrocitarios en un banco de sangre hospitalario. Estudio de un periodo de nueve años (1980-1988).