Elimination of 14C-glycated albumin from serum of rabbit.
Glycated albumin was prepared by incubation of serum from rabbits with randomly labelled 14C-glucose. The isolated glycated albumin fraction was reinfused to the same animal. 14C-labelled glucose was given to alloxan-treated rabbits. The disappearance of the radioactivity showed a rapid initial phase and a slow elimination phase, which could be acceptably described by first-order kinetics. The estimated half-life of glycated albumin was about 6 days, which is about 70% of that generally stated for albumin in the rabbit. If these findings were transferred to human conditions, the half-life of fructosamine would be in the range of 13-14 days.
Kallner
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Department of Clinical Chemistry, Karolinska Hospital, Stockholm, Sweden.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005260:Female; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006207:Half-Life; D007700:Kinetics; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin