[Effect of different fibrin sealants on fibroblast activity in skin wounds. Experimental studies in rats].
The effects of two different fibrin sealants on synthetic activity of fibroblasts in incisional skin wounds of rats were studied by tracer experiments with 14C-proline. Additionally the wounds and the subcutaneous rests of the fibrin sealants were examined histologically. When the sealants were applied immediately after wounding there was no difference to untreated controls. However, administration on day 3 after injury resulted in a significant increase of 14C-incorporation by both preparations. This stimulation of synthetic activity after retarded treatment must be caused by the direct contact between the sealants with their soluble components and the fibroblasts, which are more frequent in the wounds on day 3. Differences between the two preparations could only be observed in the histological examination of the subcutaneous fibrin clots. Preparation 2 induced stronger encapsulation, cell invasion, and fibrinolysis of the clots than preparation 1.
Nagelschmidt
M
M
Biochemische und Experimentelle Abteilung, Universität zu Köln, Merheim.
Röddecker
K
K
Gierse
T
T
Troidl
H
H
D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011392:Proline / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000293:injuries* / Q000473:pathology
D015718:Fibrin Tissue Adhesive; D011392:Proline
Einfluss verschiedener Fibrinkleber auf die Fibroblasten-Aktivität in Hautwunden. Experimentelle Untersuchungen an Ratten.