title: Leukotriene C4 elimination and metabolism in man.
abstract: Three doses of radiolabeled leukotriene C4 (0.2 to 15 muCi) were infused into three subjects to investigate its metabolism and routes of elimination during 4 days. Between 12% and 20% of the infused dose was recovered in the urine within 24 hours, of which a substantial and relatively constant proportion (4.1% to 6.3% total dose) appeared as leukotriene E4 (LTE4), mainly in the first 4 hours. Polar omega-oxidation products, N-acetyl LTE4, and tritiated water were also present. Fecal elimination accounted for a further 30% to 40% of the infused dose. In the absence of altered metabolism or biliary excretion, urinary LTE4 may be a useful measure of whole body production of the cysteinyl leukotrienes.
authors.affiliation: Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, England.
authors.forename: N H
authors.initials: NH
authors.lastname: Maltby
authors.forename: G W
authors.initials: GW
authors.lastname: Taylor
authors.forename: J M
authors.initials: JM
authors.lastname: Ritter
authors.forename: K
authors.initials: K
authors.lastname: Moore
authors.forename: R W
authors.initials: RW
authors.lastname: Fuller
authors.forename: C T
authors.initials: CT
authors.lastname: Dollery
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D013189:SRS-A / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
chemical_list: D013189:SRS-A; D014316:Tritium