title: Depression secondary to anxiety: findings from the McLean Hospital Depression Research Facility.
abstract: Methodologic issues pertinent to the study of depression secondary to anxiety are reviewed. Data on the frequency and temporal sequence of comorbid DSM-III-R anxiety and depressive disorders in a sample from the McLean Hospital Depression Research Facility are presented. Patients with major depression secondary to anxiety are compared with major depressed patients without anxiety on a variety of demographic and clinical variables. Conceptual and practical frameworks are developed for assessing and understanding comorbidity and secondary depression.
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: A F
authors.initials: AF
authors.lastname: Schatzberg
authors.forename: J A
authors.initials: JA
authors.lastname: Samson
authors.forename: A J
authors.initials: AJ
authors.lastname: Rothschild
authors.forename: M M
authors.initials: MM
authors.lastname: Luciana
authors.forename: R F
authors.initials: RF
authors.lastname: Bruno
authors.forename: T C
authors.initials: TC
authors.lastname: Bond
mesh_terms: D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000175:diagnosis / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics