title: High-density lipoprotein (HDL), HDL2, and HDL3 cholesterol concentrations determined in serum of newborns, infants, children, adolescents, and adults by use of a micromethod for combined precipitation ultracentrifugation.
abstract: Cholesterol (C) concentrations in the two major subfractions of high-density lipoproteins (HDL2-C and HDL3-C) in sera from both sexes, ages ranging from newborns to adults, were measured by use of a micromethod for combined precipitation-ultracentrifugation. Sera were obtained from 91 boys, 68 girls, 15 healthy men, and 14 women. The HDL2-C concentration was higher in women than in men; the HDL3-C concentration was similar in these two groups. This sex-related difference, generally seen in adults, was found to begin at ages 11-15 y. The value of HDL2-C in females increased with age in a stepwise manner, whereas that in males increased up to ages 6-10 y but tended to decline thereafter. The HDL3-C concentration was higher in the adults than in the children. This micromethod for separating operationally defined HDL subfractions is of value for lipoprotein research in children.
authors.affiliation: Department of Pediatrics, Yamanashi Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asayama
authors.forename: A
authors.initials: A
authors.lastname: Miyao
authors.forename: K
authors.initials: K
authors.lastname: Kato
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000097:blood*; D011232:Chemical Precipitation; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008075:Lipoproteins, HDL / Q000097:blood*; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D008297:Male; D008832:Microchemistry; D014461:Ultracentrifugation
chemical_list: D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3