Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives.
New derivatives of 2-thioxo-4,5-imidazolidinedione (3-6, 10, 11) and 2,4,5-imidazolidinetrione (7, 12) were synthesized by N,N'-acylation of asymmetric thioureas and ureas by oxalyl chloride. The obtained compounds were screened for their central action, mainly anticonvulsant activity.
Zankowska-Jasińska
W
W
Department of Organic Chemistry, Jagiellonian University, Kraków, Poland.
Borowiec
H
H
Golus
J
J
Kolasa
A
A
Zaleska
B
B
Krzywosiński
L
L
Bogdal
M
M
Przemyk
B
B
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004597:Electroshock; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010830:Physostigmine / Q000037:antagonists & inhibitors; D004856:Postural Balance / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
D000927:Anticonvulsants; D007093:Imidazoles; D013871:Thiones; D012110:Reserpine; D010830:Physostigmine; D010433:Pentylenetetrazole