Indices of hypercoagulation in cancer as compared with those in acute inflammation and acute infarction.
The mean levels of fibrinopeptide A (FPA), thrombin-antithrombin complex (TAT), and soluble fibrin (tPA method) in cancer patients (n = 32) were intermediate between those of patients with cerebral infarction and pancreatitis who had the most abnormal results and patients with myocardial infarction and pneumonia who had the least abnormal results. Patients with disseminated malignancies (n = 16) had significantly higher mean levels of FPA (10.6 vs. 5.3 nmol/l) and TAT (11.0 vs. 4.4 pmol/l) than patients with limited malignancies (n = 16). The difference in soluble fibrin (fibrin monomer, FM; 22.1 vs. 18.0 nmol/l) was not significant. The values of FPA, FM, and TAT in the patient population correlated significantly. There was a negative correlation between the level of antithrombin and test results for FPA (-0.69), FM (-0.48), and TAT (-0.38) in the cancer patients. Even cancer patients with locally limited disease may have elevated FPA, FM, and TAT test results, indicating a state of definite hypercoagulation.
Lindahl
A K
AK
Haematological Research Laboratory, Aker University Hospital, Oslo, Norway.
Sandset
P M
PM
Abildgaard
U
U
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology; D001780:Blood Coagulation Tests; D002544:Cerebral Infarction / Q000097:blood* / Q000150:complications; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005344:Fibrinopeptide A / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D009369:Neoplasms / Q000097:blood* / Q000150:complications; D010195:Pancreatitis / Q000097:blood* / Q000150:complications; D010447:Peptide Hydrolases / Q000378:metabolism; D011014:Pneumonia / Q000097:blood* / Q000150:complications; D011237:Predictive Value of Tests; D012016:Reference Values
C046193:antithrombin III-protease complex; D005344:Fibrinopeptide A; D000990:Antithrombin III; D005337:Fibrin; D010447:Peptide Hydrolases