title: Anti-inflammatory constituents of topically applied crude drugs. IV. Constituents and anti-inflammatory effect of Paraguayan crude drug "alhucema" (Lavandula latifolia Vill.).
abstract: The anti-inflammatory active fraction of the Paraguayan crude drug, "Alhucema," Lavandula latifolia Vill. afforded four compounds: coumarin (1), 7-methoxycoumarin (2), trans-phytol (3) and caryophyllene oxide (4). 1 showed a weakly inhibitory effect on carrageenin-induced paw edema in rats on topical application and 4 showed an inhibitory effect on histamine-induced contraction in guinea pig ileum.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Shogawa
authors.forename: T
authors.initials: T
authors.lastname: Matsuzawa
authors.forename: S
authors.initials: S
authors.lastname: Yonezawa
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Yoshizaki
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: E
authors.initials: E
authors.lastname: Ferro
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D001681:Biological Assay; D003374:Coumarins / Q000032:analysis*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010239:Paraguay; D010836:Phytol / Q000032:analysis*; D010946:Plants, Medicinal / Q000032:analysis*; D000081223:Polycyclic Sesquiterpenes; D051381:Rats; D012717:Sesquiterpenes / Q000032:analysis*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D010836:Phytol; C024714:caryophyllene