title: Effects of developmental exposure to methyl mercury on spatial and temporal visual function in monkeys.
abstract: Detailed characterization of several aspects of visual function was made in two groups of monkeys exposed developmentally to methyl mercury. One group of monkeys (Macaca fascicularis) was dosed from birth onward with 50 micrograms/kg/day of mercury as methyl mercury. Another group was exposed in utero by dosing the mother with 10, 25, or 50 micrograms/kg/day of mercury as methyl mercury, and postnatally until 4.0-4.5 years of age with the same dose the mother had received. Spatial and temporal visual function was tested in both groups. Spatial visual deficits observed in the group dosed beginning postnatally were reported previously (Rice and Gilbert, 1982, Science, 216, 759-761). Monkeys exposed in utero plus postnatally exhibited impaired high- and low-luminance spatial vision. They also exhibited deficits in low-frequency high-luminance temporal vision, while low-luminance temporal vision was superior to that of control monkeys. Monkeys in which exposure began at birth displayed superior low-luminance temporal vision, while high-luminance temporal vision was not impaired. These effects were observed in the absence of constriction of visual fields. These data suggest that the pattern of visual deficits produced by developmental exposure to methyl mercury may be different from that in the adult, and that the developing visual system may be able to remodel as a result of early insult by a neurotoxic agent.
authors.affiliation: Toxicology Research Division, Bureau of Chemical Safety, Ottawa, Ontario, Canada.
authors.forename: D C
authors.initials: DC
authors.lastname: Rice
authors.forename: S G
authors.initials: SG
authors.lastname: Gilbert
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D009887:Ophthalmoscopy; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology; D013998:Time Perception / Q000187:drug effects* / Q000502:physiology; D058609:Visual Field Tests; D014796:Visual Perception / Q000187:drug effects* / Q000502:physiology
chemical_list: D008767:Methylmercury Compounds; C004925:methylmercuric chloride