title: Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury.
abstract: The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented. 10 patients were selected and carefully analyzed according to Glasgow coma scale (GCS) scores and severity of brain edema. The results demonstrate that DMSO rapidly reduces the raised ICP, increases the cerebral perfusion pressure (CPP) and improves the neurological course and outcome without affecting the systemic blood pressure and patient responsiveness except only in one patient. We also point out that the rebound effect does not occur.
authors.affiliation: Neurosurgical Clinic of Dicle-University School of Medicine, Diyarbakir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kulah
authors.forename: M
authors.initials: M
authors.lastname: Akar
authors.forename: L
authors.initials: L
authors.lastname: Baykut
mesh_terms: D000293:Adolescent; D000328:Adult; D001924:Brain Concussion / Q000188:drug therapy* / Q000401:mortality; D001929:Brain Edema / Q000188:drug therapy* / Q000401:mortality; D002648:Child; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011559:Pseudotumor Cerebri / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
chemical_list: D004121:Dimethyl Sulfoxide