[Peripheral T-cell lymphoma associated with hemophagocytic syndrome: a recently identified entity. Clinico-pathologic and immunohistochemical study of 2 cases].
The authors report on two examples of peripheral T-cell lymphoma associated with hemophagocytic syndrome. The latter represents a recently described entity, which is characterized by pancytopenia, hepatosplenomegaly, fever and rapid downhill clinical course. Microscopic examination of different tissue samples shows bone-marrow, liver and spleen infiltration by small-medium sized lymphoid elements, which display peripheral T-cell phenotype and are associated with an exuberant hyperplasia of hemophagocytosing, benign-looking histiocytes. The clinical and pathological findings, along with the main differential diagnoses, are discussed.
Saragoni
A
A
Servizio di anatomia e istologia patologica, Ospedale Morgagni-Pierantoni di Forlì.
Falini
B
B
Medri
L
L
Gaudio
M
M
Brizio
R
R
Poggi
S
S
Sabattini
E
E
Pileri
S
S
D004912:Erythrocytes; D005260:Female; D015614:Histiocytosis / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013577:Syndrome
Linfoma a cellule T periferiche con associata sindrome emofagocitica: un'entità di recente identificazione. Studio clinico-patologico ed immunoistochimico di due casi.