Scleroderma-like skin lesions in two patients with phenylketonuria.
Two patients with phenylketonuria and scleroderma-like skin lesions are presented. Since scleroderma is a rare collagen disease of childhood, the occurrence of these two disorders in the same patient does not seem to be coincidental but raises the possibility of a causal relationship. Improvement in the skin lesions of the patients after the commencement of a low-phenylalanine diet supports this hypothesis.
Coşkun
T
T
Division of Metabolism, Hacettepe University, Ankara, Turkey.
Ozalp
I
I
Kale
G
G
Göğüş
S
S
D005260:Female; D006801:Humans; D007223:Infant; D010661:Phenylketonurias / Q000150:complications* / Q000628:therapy; D012594:Scleroderma, Localized / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology