[Effect of administration schedules on the antitumor activity of CPT-11, a camptothecin derivative].
Effect of administration schedules on the antitumor activity of CPT-11, a novel derivative of camptothecin, against mouse L 1210 leukemia and Meth A fibrosarcoma was investigated. At the same total dose, CPT-11 showed more significant antitumor activity by repeated administration. The most effective administration intervals were 5 days for L 1210 and 1 to 3 days for Meth A. CPT-11 showed a considerable antitumor activity by the repeated treatments for 2 or 3 times of continuous administration for 3 or 5 days.
Furuta
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Yakult Central Institute for Microbiological Research.
Yokokura
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D000077146:Irinotecan; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin