Heteroarylalkanoic acids with possible antiinflammatory activities. Part 8: The scavenging of the oxygen-free radicals.
The scavenging activity of some isosteric antiinflammatory heteoarylalkanoic acids with respect to oxygen-free radicals has been studied. All the compounds were found to inhibit the depolymerization of hyaluronic acid due to enzymatically or chemically generated hydroxyl radicals. The reduced consumption of oxygen by xanthine oxidase indicates a cotemporaneous phenomenon of enzymatic inhibition.
Parenti
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Cattedra di Chimica Farmaceutica e Tossicologica, Facoltà die Farmicia dell'Università, Modena, Italia.
Costantino
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Di Bella
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D003499:Cyclic S-Oxides / Q000138:chemical synthesis* / Q000494:pharmacology; D016166:Free Radical Scavengers; D010101:Oxygen Consumption / Q000187:drug effects; D014969:Xanthine Oxidase / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D003499:Cyclic S-Oxides; D016166:Free Radical Scavengers; D014969:Xanthine Oxidase