Long-term survival in adult hemispheric glioma: prognostic factors and quality of outcome.
Between 1983 and 1985 111 patients with hemispheric gliomas were treated with whole brain irradiation in the Department of Clinical Oncology in Edinburgh. Of these, 52 patients were treated with mixed photons and neutrons and 51 patients with photons only. The 5-year actuarial survival is 6.1%. Age and tumour grade were confirmed as significant prognostic factors (P less than 0.001). Assessment of all six adult survivors forms the basis of the morbidity report. All survivors had a degree of ataxia, spasticity and most of them showed radiological evidence of brain damage. Psychometric assessment confirmed impairment of cognitive function in all patients, as well as disruption of the socioeconomic units surrounding them. This could have been partially relieved if support was available.
Awwad
S
S
Department of Clinical Oncology, Western General Hospital, Edinburgh, UK.
Cull
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A
Gregor
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A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality* / Q000503:physiopathology / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D004651:Employment; D005260:Female; D005910:Glioma / Q000401:mortality* / Q000503:physiopathology / Q000532:radiotherapy; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012917:Social Adjustment; D015996:Survival Rate