The investigation of antiepileptic action of qingyangshen (QYS)--influences of QYS on the development of rat brain and memory behavior.
As an anticonvulsant, the influences of Qingyangshen (QYS) on the development of brain and memory behavior were observed in four-week-old male rats. The dosage of QYS was 100 mg/kg/QOD and the period of administration was one month. The results showed that QYS had less influence on the development of body weight and brain wet weight in young-aged rats than diphenylhydantoin (DPH). However, QYS inhibited the establishment of passive avoidance conditional reflex and had influence on memory behavior in young-aged rats.
Lang
S
S
Department of Neurology, Chinese PLA General Hospital.
Kuang
P
P
Liu
J
J
Zhu
K
K
Zhang
X
X
D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008568:Memory / Q000187:drug effects*; D009929:Organ Size; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000628:therapy
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D010672:Phenytoin