Safety and efficacy of long-term tocolysis with indomethacin.
Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis. The mean gestational age at the start of indomethacin therapy was 25.1 weeks (+/- 4.4), mean duration of indomethacin therapy was 43.9 days (+/- 31.4), mean gestational age at delivery 33.1 weeks (+/- 3.7). Neonatal follow-up revealed the same incidence of complications in these indomethacin-exposed infants, when they were compared with all other infants born in the same time period and exposed to intravenous tocolytics only when matched for gestational age at delivery.
Gerson
A
A
Section of Perinatology, Pennsylvania Hospital, Philadelphia.
Abbasi
S
S
Johnson
A
A
Kalchbrenner
M
M
Ashmead
G
G
Bolognese
R
R
D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors; D015145:Tocolysis
D007213:Indomethacin