[Phospholipid spectrum and the indicators of lipid peroxidation in the cerebrospinal fluid of newborn infants with perinatal lesions of the central nervous system].
A study was made of the phospholipid content and lipid peroxidation (LPO) in the cerebrospinal fluid of neonates in the early neonatal period. LPO was found to be activated in neonates with perinatal lesions of the CNS, correlating with the disease gravity. Appreciable changes in the phospholipid spectrum of the cerebrospinal fluid were revealed in all the components. The rise of the content of lysophosphatidyl choline turned out most significant. The interrelation between activation of LPO processes in the cerebrospinal fluid and changes in its phospholipid spectrum is under discussion. The characteristics under study may serve an additional diagnostic criterion for assessing the gravity of CNS lesion in neonates and should be taken into consideration in carrying out rational therapy in the acute disease period.
Reznik
B Ia
BIa
Paseniuk
T A
TA
Artemenko
I P
IP
D006801:Humans; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007231:Infant, Newborn / Q000134:cerebrospinal fluid / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000134:cerebrospinal fluid*; D010743:Phospholipids / Q000134:cerebrospinal fluid*
D010743:Phospholipids; D008315:Malondialdehyde
Fosfolipid spektr i pokazateli perekisnogo okisleniia lipidov spinnomozgovoĭ zhidkosti u novorozhdennykh s perinatal'nymi porazheniiami TsNS.