[Glomerular ultrastructures and prognosis of the patients with urinary abnormalities found by school screening program].
Detailed histopathological study were performed and compared with clinical features in 120 children with serial renal biopsies who were found by school screening program. 41 cases (34.2%) of IgA nephropathy (IgAN), 26 cases (21.7%) of thin membrane disease (TMD) and 22 cases (18.3%) of normal glomeruli [( Normal]) accounted for 74.2% of all biopsies. 81 cases (67.5%) were revealed to be minor glomerular abnormalities by light microscopy and which contained 26 cases (32.1%) of TMD, 22 cases (27.2%) of [Normal] and 19 cases (23.4%) of IgAN. The frequency and the severity of proteinuria was significantly higher in IgAN than in TMD and [Normal] (P less than 0.01, P less than 0.05). Hematuria was significantly greater in [Normal] than in IgAN. In the 71 follow-up cases, no patient went to renal insufficiency, moreover, urinary abnormalities had disappeared in 25.4% of the patients including IgAN, TMD, [Normal], nonIgA proliferative glomerulonephritis, incomplete foot process disease and MPGN. [Normal] consisted of stationary or exercised urinary abnormality.
Yanase
K
K
Second Department of Pathology, Fukuoka University, Japan.
Kaneda
K
K
Chiang
Y Y
YY
Takebayashi
S
S
D000293:Adolescent; D000367:Age Factors; D002648:Child; D005260:Female; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000473:pathology / Q000652:urine; D015433:Glomerulonephritis, Membranous / Q000453:epidemiology / Q000473:pathology / Q000652:urine; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008297:Male; D008403:Mass Screening; D011379:Prognosis; D012574:Schools