Heparin-coated equipment reduces complement activation during cardiopulmonary bypass in the pig.
Complement activation was studied during cardiopulmonary bypass (CPB) in the pig. One group of animals was perfused for 2 h using a standard extracorporeal circuit including a hollow fiber membrane oxygenator with full systemic heparinization. Another group was treated in the same way, except that bypass was performed through a heparin-coated CPB circuit (Carmeda Bio-Active Surface, CBAS) and systemic heparinization was reduced by 75%. It was found that complement activation during CPB, measured as changes in the ratio C3d/C3, was significantly less in the CBAS group, most probably reflecting a better biocompatibility.
Nilsson
L
L
Department of Thoracic Surgery, University Hospital, Uppsala, Sweden.
Storm
K E
KE
Thelin
S
S
Bagge
L
L
Hultman
J
J
Thorelius
J
J
Nilsson
U
U
D000818:Animals; D001672:Biocompatible Materials; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015933:Complement C3d / Q000032:analysis; D006493:Heparin; D010107:Oxygenators, Membrane; D013552:Swine
D001672:Biocompatible Materials; D003176:Complement C3; D015933:Complement C3d; D006493:Heparin