title: [Fertilization in vitro with failure of cleavage. A proposal of therapeutic or diagnostic management for future trials].
abstract: This is a retrospective study of IVF cycles with failure of cleavage at the PMA centre of the University Hospital, Pitie-Salpetriere occurring between May 1985 and December 1988. Failures of cleavage occurred in 23% of the cycles where at least one oocyte was recovered (170 out of 729 cycles). There were three groups of conditions which were analysed: 1. The male factor which was known about before the attempt at IVF (38 cycles - 23% of failures of cleavage). 2. No previously known male factors (126 cycles-74% of failures of cleavage). 3. IVF with frozen donor sperm (6 cycles-3% of failures of cleavage). These couples had a total of 340 cycles with 25 pregnancies. The prognosis differs according to the category mentioned above. If there is a male factor, one attempt at IVF with this partner's sperm seems absolutely justified before proceeding to IVF with donor sperm or to AID. If there is no male factor the oestradiol curve does not make it possible to foresee a failure of cleavage and it is necessary to carry out a second IVF cycle to handle these couples.
authors.affiliation: Service de Gynécologie-Obstétrique, CHU Pitié-Salpêtrière, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Vauthier-Brouzes
authors.forename: G
authors.initials: G
authors.lastname: Lefebvre
mesh_terms: D000328:Adult; D002970:Cleavage Stage, Ovum / Q000473:pathology*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005615:Freezing; D006801:Humans; D008297:Male; D010063:Ovum / Q000473:pathology; D012189:Retrospective Studies; D013074:Sperm Banks; D013076:Sperm Count; D013094:Spermatozoa / Q000502:physiology
vernacular_title: FIV avec échec de segmentation. Proposition d'une conduite thérapeutique ou diagnostique pour les tentatives à venir.