Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone.
The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more active than the sulfoxide although methionine was most active indicating that the antiinflammatory activity is not correlated with the oxidation state of sulphur. Their hydroxyl radical scavenging activity was measured. Methionine was most active and sulfone was least active. Here also no correlation with antiinflammatory activity was found.
Unnikrishnan
M K
MK
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D016166:Free Radical Scavengers; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; C018332:methionine sulfone; D002351:Carrageenan; D008715:Methionine; C013111:methionine sulfoxide