[Inflammation-inhibiting effect of magnesium ions in contact eczema reactions].
Water containing high concentrations of magnesium ions (e.g. Dead Sea water) is effective in the treatment of inflammatory skin diseases. Therefore, we examined the influence of Mg2+ on inflammation in allergic contact dermatitis induced by 1-chloro-2,4-dinitrobenzene (DNCB) in BALB/c mice. Animals challenged with 0.125% DNCB in the presence of magnesium chloride (28% and 14%) demonstrated significantly less pronounced contact dermatitis (ear swelling) than did animals challenged with DNCB alone (p less than 0.001 and p less than 0.01). In mice challenged with DNCB in combination with sodium chloride (14%) there was no statistically significant difference in the degree of ear swelling. These results were borne out in 5 patients known to be allergic to nickel, in whom magnesium chloride but not sodium chloride, suppressed nickel sulphate-induced contact dermatitis.
Greiner
J
J
Universitäts-Hautklinik, Humboldt-Universität zu Berlin Charité.
Diezel
W
W
D000293:Adolescent; D000328:Adult; D000818:Animals; D003877:Dermatitis, Contact / Q000628:therapy*; D004137:Dinitrochlorobenzene; D005260:Female; D006801:Humans; D007477:Ions; D015636:Magnesium Chloride / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009532:Nickel / Q000009:adverse effects; D012965:Sodium Chloride / Q000494:pharmacology
D004137:Dinitrochlorobenzene; D007477:Ions; D015636:Magnesium Chloride; D012965:Sodium Chloride; D009532:Nickel
Entzündungshemmende Wirkung von Magnesium-Ionen bei der Kontaktekzem-Reaktion.