Model systems to study immunomodulation in domestic food animals.
Development of immunomodulators for use in food producing animals is an active area of research. This research has generally incorporated aspects of immunosuppression in model systems. This methodology is appropriate because most of the research has been aimed at developing immunomodulators for certain economically significant diseases in which immunosuppression is believed to be an important component of their pathogenesis. The primary focus has been on stress-associated diseases (especially bovine respiratory disease), infectious diseases in young animals, and mastitis. The model systems used have limitations, but they have demonstrated that immunomodulators are capable of significantly increasing resistance to these important infectious disease syndromes. As our understanding of molecular immunology increases and as more potential immunomodulators become available, the use of relevant model systems should greatly aid advancement in the field of immunomodulation.
Roth
J A
JA
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames 50011.
Flaming
K P
KP
D000818:Animals; D000829:Animals, Domestic; D004195:Disease Models, Animal; D007108:Immune Tolerance; D007239:Infections / Q000276:immunology / Q000662:veterinary*; D013312:Stress, Physiological / Q000276:immunology / Q000662:veterinary*; D014186:Transportation; D014886:Weaning