title: Vasculitis with recurrent pulmonary hemorrhage in a long-term survivor after autologous bone marrow transplantation.
abstract: We report an unusual vasculitic syndrome in a long-term survivor of autologous bone marrow transplant. Clinical and pathologic studies revealed a cutaneous and pulmonary leukocytoclastic vasculitis complicated by recurrent pulmonary hemorrhage. Serologic studies revealed an elevated anti-neutrophil cytoplasmic antibody titer. The vasculitis has been successfully controlled with prednisone, cyclophosphamide, and trimethoprim/sulfamethoxazole.
authors.affiliation: Division of Clinical Oncology, Dana-Farber Cancer Institute, Boston, MA.
authors.forename: M V
authors.initials: MV
authors.lastname: Seiden
authors.forename: W J
authors.initials: WJ
authors.lastname: O'Donnell
authors.forename: M
authors.initials: M
authors.lastname: Weinblatt
authors.forename: J
authors.initials: J
authors.lastname: Licht
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006470:Hemorrhage / Q000150:complications / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000209:etiology*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014295:Trimethoprim / Q000627:therapeutic use; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis / Q000209:etiology*
chemical_list: D003520:Cyclophosphamide; D014295:Trimethoprim; D013420:Sulfamethoxazole; D011241:Prednisone