[Interactions of lipid micelles with blood proteins].
Interaction of lipid micelles (LM), containing cholesterol and hydroxycholesterol, with human serum lipoproteins was investigated. It was shown that cholesterol-containing LM interact with low density lipoproteins (LDL). Selectivity of LM-LDL interaction depended on the cholesterol content of micelles and almost did not depend on the composition of LM core. Up to 90% of LDL were bound with cholesterol-saturated LM. By means of gel chromatography it was shown that interaction of cholesterol- and 7-hydroxycholesterol-containing micelles with serum led to the partial fusion of LDL with LM and LDL-LM complex formation, as well as to the cholesterol and 7-hydroxycholesterol transfer from micelles to LDL. The obtained results indicate that cholesterol-containing LM can be used for the delivery of oxidized cholesterol to cells involving LDL and receptor-dependent pathway of their capture by peripheral cells.
Berezov
A T
AT
Ivanov
A S
AS
Echkalov
A P
AP
Khalilol
E M
EM
Archakov
A I
AI
D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D002850:Chromatography, Gel; D006801:Humans; D006888:Hydroxycholesterols / Q000032:analysis / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis*; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008823:Micelles
D006888:Hydroxycholesterols; D008055:Lipids; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008823:Micelles; D002784:Cholesterol
Vzaimodeĭstvie lipidnykh mitsell s lipoproteinami syvorotki krovi.