[Treatment of radiostomatitis with Salcoat].
Most malignancies occurring in the oral cavity are squamous carcinoma for which radiotherapy as a treatment is the first choice. However, radiostomatitis, which occurs as a concomitant symptom due to radiation, largely disturbs the effect of radiotherapy. Antibiotics or a gargle are used to treat this concomitant symptom, but these preparations are not satisfactorily effective especially in cases in which the symptoms are severe and/or wide spread. Salcoat, a spray-type preparation of Beclomethasone dipropionate that is used to treat stomatitis, has excellent features which compensate for the disadvantage of the previously mentioned therapy. This preparation can be administered in a non-contact manner, and it contains hydroxypropyl cellulose which assures good adhesion to the mucosa, thus covering and protecting the affected area for a long time. In our clinical trials, this preparation was found to be highly useful in relieving pain and dysgeusia due to radiostomatitis, there by maintaining the quality of life.
Ishii
J
J
Dept. of Oral Surgery, Kobe Univ., School of Med.
Nakanishi
K
K
Shimada
K
K
D000328:Adult; D000368:Aged; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000188:drug therapy*; D011879:Radiotherapy Dosage; D012464:Saliva, Artificial / Q000627:therapeutic use; D013280:Stomatitis / Q000188:drug therapy*
D004338:Drug Combinations; D012464:Saliva, Artificial; D002482:Cellulose; C008079:hydroxypropylcellulose; D001507:Beclomethasone