HLA phenotypes in patients who have osteosarcoma.
Human leukocyte antigen (HLA) phenotypes were studied in twenty Japanese patients who had typical osteosarcoma. The HLA-A11 phenotype was found in ten (50 per cent) of the twenty patients, compared with 16.6 per cent of 235 control subjects (chi square = 13.248; p less than 0.0005)--an odds ratio of 5.026. These data suggest that major histocompatibility complex-linked genes may determine susceptibility to osteosarcoma.
Shimizu
T
T
Department of Orthopaedic Surgery, Gunma University School of Medicine, Japan.
Chigira
M
M
Nagase
M
M
Watanabe
H
H
Udagawa
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000276:immunology*; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens / Q000032:analysis / Q000235:genetics; D059870:HLA-A11 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011379:Prognosis
D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen