title: Intravenous ofloxacin in severe infections.
abstract: The efficacy and tolerance of intravenous ofloxacin was studied in 70 patients suffering from soft tissue infections (n = 33), intra-abdominal abscesses (n = 14), septicaemia (n = 12), pneumonia (n = 9) and brucellosis (n = 2). The average daily dose was 6 mg/kg divided into two doses. Pathogens treated included Enterobacter cloacae (n = 14), Escherichia coli (n = 12), Staphylococcus aureus (n = 13), Pseudomonas aeruginosa (n = 11), Klebsiella pneumoniae (n = 10), Enterococcus faecalis (n = 8) and Streptococcus spp. (n = 5). Most patients had several underlying diseases. Most of the patients had received other antibiotic therapy without success. Clinically, 41% were considered cured, 19% improved and 30% failed to respond. Bacteriologically, pathogens were eradicated in 52.5% and persisted in 22.5%. Adverse reactions included an anaphylactoid reaction, abnormal liver function (n = 13) and insomnia (n = 2). This study suggests that higher doses of ofloxacin may be needed in deep seated infections.
authors.affiliation: Department of Chemotherapy, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: E
authors.initials: E
authors.lastname: Presterl
authors.forename: B
authors.initials: B
authors.lastname: Walzl
authors.forename: R
authors.initials: R
authors.lastname: Lackner
authors.forename: B
authors.initials: B
authors.lastname: Haslinger
authors.forename: W
authors.initials: W
authors.lastname: Hackl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D015242:Ofloxacin