Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone.
Hepatoprotective actions of metadoxina and ubiquinone have been studied in alcoholic rats by evaluating hepatic triglyceride accumulation and serum biochemical parameters of liver function. The two drug-treated groups displayed significantly lower triglyceride concentrations as compared to the ethanol-treated group. No significant differences were found among the two drug-treated and the control groups. Electron-microscopic abnormalities were found only in ethanol-treated rats. Serum biochemical parameters of liver function did not show any significant difference among all four groups. These results suggest a possible protective role of metadoxina and ubiquinone in ethanol-induced liver triglyceride accumulation.
Marchi
S
S
First Medical Clinic, University of Pisa, Italy.
Polloni
A
A
Costa
F
F
Bellini
M
M
Bonifazi
V
V
Tumino
E
E
Grassi
B
B
Romano
M R
MR
De Bartolo
G
G
Bertelli
A
A
D000818:Animals; D004338:Drug Combinations; D000431:Ethanol / Q000494:pharmacology*; D005234:Fatty Liver / Q000139:chemically induced / Q000517:prevention & control; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009994:Osmolar Concentration; D011736:Pyridoxine / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology*
D004338:Drug Combinations; D014280:Triglycerides; D014451:Ubiquinone; D000431:Ethanol; C037845:metadoxine; D011736:Pyridoxine; D011761:Pyrrolidonecarboxylic Acid