The effects of intermittent and continuous intravenous infusion of famotidine on gastric acidity in patients with peptic ulcers.
The effects of intermittent or continuous intravenous infusion of a daily dose of 40 mg of famotidine on the intragastric pH over a 24-hour period were studied in five patients with gastric ulcers and five with duodenal ulcers. Gastric pH was measured continuously using a pH meter. Famotidine was administered at 12-hour intervals for intermittent infusion or was given by continuous infusion. The mean cumulative percentage of pH readings at 6 to 7 or above with continuous infusion was significantly higher than with intermittent infusion in both gastric and duodenal ulcer patients. Thus, the continuous intravenous infusion of a daily dose of 40 mg of famotidine appears to be more useful for the preservation of a high gastric pH in gastric and duodenal ulcer patients than the intermittent infusion of the same daily dose of famotidine.
Watanabe
Y
Y
Department of Surgery, Izunagaoka Hospital, Juntendo University School of Medicine, Shizuoka, Japan.
Tsumura
H
H
Sasaki
H
H
Morimoto
T
T
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000188:drug therapy*; D015738:Famotidine / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy*; D013997:Time Factors
D015738:Famotidine