title: Characteristics of the umbilical artery velocity waveform as function of measurement site.
abstract: In 30 uncomplicated singleton pregnancies, varying in duration between 24 and 40 weeks, the variability of the flow velocity waveform (FVW) along the course of the umbilical artery was investigated. Blood flow velocities were recorded at 4 locations in the vessel: within the fetal abdomen, 0-5 cm from the origin of the umbilical cord, in the free-floating part, and 0-5 cm from its insertion in the placenta. From the Doppler signals recorded, the pulsatility index (PI) and a parameter for the frequency distribution index (FDI) were calculated. PI values differed among the locations, but no unequivocal tendency could be demonstrated. Statistical analysis, including multiple regression analysis for maternal and menstrual age and fetal heart rate, showed no significant difference in PI and FDI values for any of the 4 locations. It can be concluded that in uncomplicated pregnancies, possible changes in FVW (quantified by PI) along the course of the umbilical artery have no clinical relevance. Therefore, standardization for the sampling site when measuring PI in this vessel seems to be unnecessary.
authors.affiliation: Department of Biophysics, University of Limburg, Maastricht, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Ruissen
authors.forename: M M
authors.initials: MM
authors.lastname: von Drongelen
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoogland
authors.forename: W
authors.initials: W
authors.lastname: Jager
authors.forename: A P
authors.initials: AP
authors.lastname: Hoeks
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology; D010925:Placental Function Tests; D011247:Pregnancy; D011673:Pulsatile Flow / Q000502:physiology; D014465:Ultrasonics; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*