Radiosensitivity of murine and human melanoma cells: a comparative study with different models.
The in vitro radiosensitivity of one murine melanoma cell line (Cloudman S91 CCL 53.1) and three human melanoma cell strains (C8146C, C8161, and R83-4) were studied. Cells were irradiated by single dose X-rays and plated either in agar or on plastic. The survival curves were fitted by the single-hit multitarget, two-hit multitarget, and quadratic models. Multiple comparisons of the residual sum of squares suggested that the two-hit model was clearly inferior to the single-hit and quadratic models. No statistically significant difference was suggested for either the single-hit or quadratic models. Furthermore, on examination of the differences in correlations between the observed and predicted values, the residual plots (observed minus predicted over dose) failed to suggest a clear advantage of either the single-hit multitarget or the quadratic models. Either model could be recommended for analysis of in vitro radiation data.
Yohem
K H
KH
Department of Internal Medicine, University of Arizona, Tucson 85724.
Slymen
D J
DJ
Bregman
M D
MD
Meyskens
F L
FL
D000818:Animals; D002460:Cell Line; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000503:physiopathology / Q000532:radiotherapy; D051379:Mice; D008811:Mice, Inbred DBA; D008954:Models, Biological; D011836:Radiation Tolerance / Q000235:genetics / Q000502:physiology*