title: [Clinical study of the efficacy and tolerability of nimesulide in suppositories compared to flurbiprofen in gynecology].
abstract: The efficacy and tolerability of nimesulide in a new pharmaceutical suppository form were assessed in a double blind study versus flurbiprofen in pain-inflammatory pathologies of obstetrico-gynecological nature. One hundred patients with pelvic inflammatory disease were randomly assigned to treatment with nimesulide or flurbiprofen. Both drugs, administered in a dose of 2 suppositories a day for 7 days, evidenced speedy, effective analgesic and anti-inflammatory activity combined with good tolerability. Specifically, as regards the pain component, nimesulide demonstrated a significantly more marked analgesic effect than flurbiprofen in the first two hours of treatment.
authors.affiliation: Istituto di I Clinica Ostetrica e Ginecologica, Università di Catania, Ospedale Vittorio Emanuele II.
authors.forename: C
authors.initials: C
authors.lastname: Montoneri
authors.forename: A
authors.initials: A
authors.lastname: Garofalo
authors.forename: S
authors.initials: S
authors.lastname: Iurato
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
authors.forename: R
authors.initials: R
authors.lastname: Trezzani
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000009:adverse effects; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D013488:Suppositories
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D013488:Suppositories; D005480:Flurbiprofen; C012655:nimesulide
vernacular_title: Studio clinico sull'efficacia e la tollerabilità della nimesulide in formulazione supposte in confronto al flurbiprofen in ginecologia.