title: Effects of hypoxemia with and without acidemia on the isometric contraction time and the electromechanical delay of the fetal myocardium: an experimental study on the ovine fetus.
abstract: This study assessed the response of the preejection period during hypoxemia with and without acidemia. In five pregnant ewes, hypoxemia was created during 1 hour followed by fetal infusion of lactic acid during 2 hours. A micromanometer catheter positioned above the fetal aortic valve, an endocavitary phonocardiogram, and a fetal electrocardiogram allowed measurements of the two components of the preejection period--the isometric contraction time and the electromechanical delay. At the onset of hypoxemia, because of changes in isometric contraction time, the preejection period began to shorten. When acidemia was induced, the preejection period modified slowly in the opposite direction and lengthened, initially because of a prolongation of electromechanical delay and later because of an increase in the already shortened isometric contraction time. This process developed slowly and at the end of 2 hours of acidemia, preejection period were back to preexperimental values. It can be concluded that systolic time intervals can be normal and misleading when acidosis complicates hypoxemia.
authors.affiliation: Department of Pediatrics, Hôspital Sainte-Justine, University of Montreal, Quebec, Canada.
authors.forename: J C
authors.initials: JC
authors.lastname: Fouron
authors.forename: J S
authors.initials: JS
authors.lastname: Lafond
authors.forename: H
authors.initials: H
authors.lastname: Bard
mesh_terms: D000143:Acids / Q000097:blood*; D000818:Animals; D001696:Biomechanical Phenomena; D004594:Electrophysiology; D005260:Female; D005318:Fetal Heart / Q000503:physiopathology*; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D007537:Isometric Contraction; D009119:Muscle Contraction; D009200:Myocardial Contraction; D011247:Pregnancy; D012756:Sheep; D013997:Time Factors
chemical_list: D000143:Acids