title: [The anti-arrhythmia activity of isoteolin (IST)].
abstract: The antiarrhythmic activity of IST was studied on some experimental models of cardiac arrhythmia--caused by adrenaline in rats, caused by barium in non-narcotized rabbits, caused by strophanthin in guinea pigs, caused by aconitine and calcium in rats. Rhythmic disturbances were recorded by a 12-channel polyphysiograph "Galileo" or a single-channel electrocardiograph "Cardiomat". The obtained results showed that IST manifested antiarrhythmic activity in respect to adrenaline, barium and strophanthin arrhythmias without affecting substantially aconitine and calcium arrhythmias. It is thought that antiarrhythmic activity of IST, found in the indicated experimental models of cardiac arrhythmias, is most probably connected with a lowering of the peripheral sympathetic activity, realized by a central way.
authors.forename: M
authors.initials: M
authors.lastname: Markov
authors.forename: D
authors.initials: D
authors.lastname: Zheliazkov
authors.forename: G
authors.initials: G
authors.lastname: Iakimov
mesh_terms: D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001060:Aporphines / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001464:Barium; D017609:Barium Compounds; D002118:Calcium; D002712:Chlorides; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D013328:Strophanthins
chemical_list: D000889:Anti-Arrhythmia Agents; D001060:Aporphines; D017609:Barium Compounds; D002712:Chlorides; D013328:Strophanthins; C024986:barium chloride; D001464:Barium; C044170:isoteolin; C029082:strophanthin K; D002118:Calcium; D000157:Aconitine; D004837:Epinephrine
vernacular_title: Vŭrkhu antiaritmichnata aktivnost na izoteolina (IZT).