Rhabdomyosarcoma with heterologous cartilage of the uterine cervix: a clinicopathologic and immunohistochemical study of an aggressive neoplasm in a young female.
This report concerns a 20-year-old female who had a F.I.G.O. stage I rhabdomyosarcoma (sarcoma botryoides) of the cervix with a predominant embryonal pattern and heterologous cartilage that pursued an aggressive course despite surgery and chemotherapy. The patient had a pelvic recurrence, developed pulmonary metastases 15 months after diagnosis, and died 6 months later. Despite some previously published favorable prognostic assessments about this unique variant of cervical rhabdomyosarcoma, our limited experience would interject a note of caution, especially in the presence of a focal alveolar pattern and invasion of lymphatics in the cervix.
Perrone
T
T
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Hospital and Clinic, Minneapolis.
Carson
L F
LF
Dehner
L P
LP
D000328:Adult; D002356:Cartilage / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D010386:Pelvic Neoplasms / Q000556:secondary; D012208:Rhabdomyosarcoma / Q000473:pathology* / Q000556:secondary; D002583:Uterine Cervical Neoplasms / Q000473:pathology*