Influence of neurohypophyseal hormones on human cervical smooth muscle contractility in vitro.
Cervical tissue strips from nonpregnant women and women in early and term pregnancy were used to study spontaneous contractile activity and the effects of oxytocin and vasopressin in vitro. Oxytocin stimulated contractions in strips from all groups of patients except for those from five term pregnant women, in which an inhibitory effect was observed at a high concentration. Vasopressin had a stimulatory effect in all groups of patients. These neurohypophyseal hormones may interact with the effect of other hormones in their regulatory influence on cervical contractility, and this interaction might be important in cervical dilatation during labor as well as in the pathophysiology of dysmenorrhea.
Bryman
I
I
Department of Obstetrics and Gynecology, University of Göteborg, Sahlgrenska Hospital, Sweden.
Norström
A
A
Lindblom
B
B
D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D012016:Reference Values; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D010121:Oxytocin