Studies of hydroxy-aluminum phosphates obtained from pentahydroxy-dialuminum chloride and monosodium phosphate.
Structural studies of hydroxy-aluminum phosphates with antacid application are performed. The antacid properties of the products depend on their chemical composition and way of preparation. Scanning electron microscope, X-ray- and IR-spectroscopy have evidenced the formation of a one-phase product. The IR-spectra indicate an Al-PO4 containing compound with an Al-PO4 bond. The high-temp. exothermic effect at 730-780 degrees C exhibited by the DTA curves of the hydroxy aluminum phosphates studies are due to polymorphic conversions which are not found with the sample having the best antacid properties. On the basis of these results it is not easy to prove that the higher acid-binding ability of this sample is due to the more favourable position of its acid-binding groups and the absence of phases undergoing polymorphic transformations at high temp. Probably the low pH value of precipitation favours the acid-binding ability. Toxicologic investigations on aluminum ion absorption in blood plasma have shown an admissible aluminium level.
Misheva
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D000535:Aluminum / Q000097:blood* / Q000737:chemistry*; D017607:Aluminum Compounds; D000536:Aluminum Hydroxide / Q000737:chemistry*; D000863:Antacids / Q000737:chemistry*; D006801:Humans; D010710:Phosphates / Q000737:chemistry*
D017607:Aluminum Compounds; D000863:Antacids; D010710:Phosphates; D000536:Aluminum Hydroxide; D000535:Aluminum; C012714:aluminum phosphate; C016976:aluminum chlorhydrate; C018279:sodium phosphate