Plasma renin activity and urine beta 2-microglobulin during and after cardiopulmonary bypass: pulsatile vs non-pulsatile perfusion.
Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P;n = 7) or non pulsatile (NP;n = 7) perfusion. In the two groups prebypass values of plasma renin activity (PRA) and urine beta 2-microglobulin (beta 2-M) were within normal limits. PRA increased significantly during CPB and the first 6 h after CPB only in the non-pulsatile group. In both groups, the urine beta 2-M level increased significantly during and after CPB; however, there was no significant difference in urine beta 2-M levels between the two groups. Also, the amount of beta 2-M excreted in urines per unit of time increased significantly in both groups during and after CPB; there was no significant difference between the two groups.
Canivet
J L
JL
Department of Anaesthesiology and Surgical Intensive Care, University of Liège, Belgium.
Larbuisson
R
R
Damas
P
P
Blaffart
F
F
Faymonville
M
M
Limet
R
R
Lamy
M
M
D000368:Aged; D002315:Cardiopulmonary Bypass; D006801:Humans; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D011673:Pulsatile Flow; D012083:Renin / Q000097:blood*; D001613:beta 2-Microglobulin / Q000652:urine*
D001613:beta 2-Microglobulin; D012083:Renin