Characterization of mechanisms of resistance to beta-lactam antibiotics in methicillin-resistant strains of Staphylococcus saprophyticus.
The resistance mechanisms of methicillin-resistant strains of Staphylococcus saprophyticus were characterized. Penicillin-binding protein (PBP) studies demonstrated an inducible PBP identical to PBP 2a in the membranes of these isolates. The amount of beta-lactamase produced was minimal. PBP 2a is responsible for the methicillin resistance observed in these strains of S. saprophyticus.
Stratton
C W
CW
Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2561.
Gelfand
M S
MS
Gerberding
J L
JL
Chambers
H F
HF
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins; D015153:Blotting, Western; D002352:Carrier Proteins; D002437:Cefazolin / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006602:Hexosyltransferases / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance / Q000502:physiology*; D009097:Multienzyme Complexes / Q000378:metabolism; D002267:Muramoylpentapeptide Carboxypeptidase; D009254:Nafcillin / Q000494:pharmacology; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000494:pharmacology; D010449:Peptide Mapping; D010458:Peptidyl Transferases / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D009254:Nafcillin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases; D002437:Cefazolin; D008712:Methicillin; D002512:Cephalothin