title: [Construction and application of atropine flow-through sensor in flow injection analysis].
abstract: A new kind of flow-through sensor for atropine has been studied. It exhibits Nernstian response for atropine with a slope of 54 +/- 1 mV/decade over the concentration range of 0.02-200 mmol/L at pH 5-8. The sensitivity coefficients of common compounds were determined. Only bromo-geramine, clonidine, strychnine and amantadine showed remarkable interference. Direct potentiometry for determination of atropine showed an average recovery of 99.2% and a relative standard deviation of 1.3%. It has been used in flow injection analysis (FIA) of atropine, anisodamine and scopolamine and belladonna preparations. Rate of analysis of as high as 60-100 samples/h was achieved.
authors.affiliation: Hubei Provincial Institute for Drug Control, Wuhan.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Liu
authors.forename: P Z
authors.initials: PZ
authors.lastname: Wu
authors.forename: Z
authors.initials: Z
authors.lastname: Yan
authors.forename: C H
authors.initials: CH
authors.lastname: Yang
authors.forename: A J
authors.initials: AJ
authors.lastname: Li
authors.forename: R Z
authors.initials: RZ
authors.lastname: Xu
mesh_terms: D001532:Atropa belladonna / Q000032:analysis; D001285:Atropine / Q000032:analysis*; D008722:Methods; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012601:Scopolamine / Q000032:analysis; D012991:Solanaceous Alkaloids / Q000032:analysis; D014665:Vasodilator Agents / Q000032:analysis
chemical_list: D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D001285:Atropine; D012601:Scopolamine