title: The occurrence of variant Ph translocations in chronic myeloid leukemia (CML): a report of six cases.
abstract: Variants of Philadelphia chromosome (Ph) translocation were detected in six of 95 Ph positive chronic myeloid leukemia (CML) patients (6.3 per cent). Two of these patients showed a Ph variant of 'simple' type, involving chromosomes 10 and 12. In four patients, the variant Ph was of 'complex' type involving a third chromosome:chromosomes 1, 6, 7 and 12 in addition to 9 and 22. Two of these resulted in the occurrence of a 'masked' Ph. In addition to variant Ph translocations, variant breakpoints such as q12 (two patients) and q13 (one patient) on chromosome 22 were observed in another three patients with t(9;22).
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Kadam
authors.forename: G J
authors.initials: GJ
authors.lastname: Nanjangud
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002892:Chromosomes, Human, Pair 22; D005260:Female; D014644:Genetic Variation; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic / Q000235:genetics*