[The search for new antiparasitic agents. 1. The synthesis and study of the acute toxicity of new halogen-containing benzamides].
The paper presents the results of toxicological study of 44 compounds of the benzamide series synthesized during search for new anthelminthic agents. The dependence of the toxic effect of the benzamides synthesized on their structure is analysed. The experiments were carried out on white mice given the compounds under study once orally. The maximum tolerated doses of the compounds are presented. It has been found that 34 out of 44 compounds have a low toxicity and are worth of further anthelminthic screening.
Mikhaĭlitsyn
F S
FS
Lebedeva
M N
MN
Kozyreva
N P
NP
Bolotina
L A
LA
Lychko
N D
ND
D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D008297:Male; D051379:Mice; D010271:Parasites / Q000187:drug effects*
D001549:Benzamides
Izyskanie novykh protivoparazitarnykh sredtsv. Soobshchenie 1. Sintez i izuchenie ostroĭ toksichnosti novykh galoidsoderzhashchikh benzamidov.