Properdin factor B allotypes in diabetic Nigerians. A preliminary report on chromosome 6 markers.
Properdin factor B(Bf) allotypes were determined in patients with insulin dependent (type 1) diabetes mellitus (n = 15); in patients with non-insulin dependent diabetes mellitus n = 15); and in healthy Nigerians (n = 252) from various tribal groups. In all three groups only commonly reported Bf allotypes namely BfF, F1, S and S1 were observed. More important, BfF1 allele was significantly increased in patients with insulin dependent (type 1) diabetes mellitus (expected 1/15, observed 5/15), X2 = P less than 0.005). It is suggested that this allele is probably the same as that reported in caucasoids and is part of a supratype or ancestral haplotype defined by HLA-B18, C4A3, C4A3, BQo, BfF1, DR3 marking type 1 (insulin dependent) diabetes mellitus.
Uko
G P
GP
Department of Medicine (Immunology Unit) Ahmadu Bello University Hospital, Zaria, Nigeria.
Onyemelukwe
G C
GC
Dawkins
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RL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044383:Black People; D002896:Chromosomes, Human, Pair 6; D011415:Complement Factor B / Q000097:blood / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009549:Nigeria
D005819:Genetic Markers; D011415:Complement Factor B