title: Clinical and prognostic significance of lung thallium uptake on rest imaging in acute myocardial infarction.
abstract: Exercise-induced pulmonary uptake of thallium-201 in patients with ischemic heart disease is probably due to transient pulmonary edema and left ventricular failure induced by exercise. The significance of increased lung uptake of thallium-201 at rest after acute myocardial infarction (AMI) has not been described. Ninety-six patients admitted with chest pain for suspected AMI or unstable angina underwent thallium-201 imaging at rest. Using conventional diagnostic criteria, 62 had AMI, 12 had unstable angina and 22 had neither. Increased lung uptake of thallium-201 was present in 24 of the total 96 (25%) patients, 20 of the 62 (32%) patients with AMI and 4 of 34 (13%) patients with no evidence of infarction. In the AMI group, those with increased lung thallium-201 uptake had a higher mean +/- standard deviation segmental thallium-201 defect score (22 +/- 7 vs 12 +/- 8, p less than 0.0001), lower ejection fraction (35 +/- 14 vs 49 +/- 14%, p less than 0.002), higher peak creatine kinase levels (2,410 +/- 1,247 vs 1,496 +/- 1,228 IU/liter, p less than 0.01), higher wall motion abnormality score (25 +/- 13 vs 13 +/- 12, p less than 0.0001), increased incidence of clinical in-hospital heart failure (15 of 20 vs 7 of 42, p less than 0.0001) and higher short-term mortality (4 of 20 vs 1 of 42, p less than 0.02) compared to those without increased lung thallium-201 uptake.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Jain
authors.forename: A
authors.initials: A
authors.lastname: Lahiri
authors.forename: E B
authors.initials: EB
authors.lastname: Raftery
mesh_terms: D000789:Angina, Unstable / Q000000981:diagnostic imaging / Q000378:metabolism; D000792:Angiography; D017023:Coronary Angiography; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012146:Rest; D016019:Survival Analysis; D013794:Thallium Radioisotopes / Q000378:metabolism*
chemical_list: D013794:Thallium Radioisotopes