[Effect of using nifedipine by patients with chronic congestive heart failure treated with digoxin and furosemide].
Nifedipine was administrated to 25 patients with chronic congestive heart failure treated with digoxin and furosemide++, nifedipine (NF) in a daily dose of 30-80 mg for 14 days. Before and after the treatment with nifedipine chest X-ray, blood biochemical investigations, echocardiographic evaluation of the left ventricular function and submaximal exercise test were performed. Nifedipine induced significant decreases in the left ventricular systolic dimension, heart volume, blood serum potassium and uric acid concentrations and hematocrit . Resting and exertional heart rate, blood pressure, exercise power and duration, watt-pulse, myocardial oxygen demand index, ejection fraction, cardiac output, body weight, 24-hour urinary output, blood serum concentrations of urea, creatinine, sodium and chloride changed insignificantly following nifedipine administration. The obtained results suggest that long-term nifedipine treatment of patients who were already given digoxin and furosemide neither improve nor worsen their clinical status.
Markiewicz
K
K
Z I Kliniki Chorób Wewnetrznych Instytutu Medycyny Wewnetrznej WAM W Lodzi.
Górski
L
L
Cholewa
M
M
Gawor
Z
Z
Dryjański
T
T
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004077:Digoxin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*
D004077:Digoxin; D005665:Furosemide; D009543:Nifedipine
Skutki stosowania nifedypiny u chorych na przewlekła zastoinowa niewydolność serca leczonych digoksyna i furosemidem.