A comparison of sclerosing agents: clinical and histologic effects of intravascular sodium tetradecyl sulfate and chromated glycerin in the dorsal rabbit ear vein.
The dorsal marginal rabbit ear vein was injected with 0.25 ml of 0.1% or 0.25% sodium tetradecyl sulfate (STS) (Sotradecol Injection) or undiluted or 50% Scleremo (Scl) (chromated glycerin). Only the 50% Scl solution failed to produce clinical or histologic thrombosis at 1 hour. Clinical fading was observed in STS-treated vessels at 10 days postinjection. Histologically, early thrombus formation with focal endothelial necrosis was replaced by fibrosis and microangiopathic recanalization. Although undiluted Scl caused similar, yet milder histologic findings, luminal recanalization after 10 days resulted in a clinically unfaded vessel. The use of 50% Scl produced no endothelial damage with no subsequent change in vessel appearance. Cutaneous necrosis or extravasation of erythrocytes was not observed.
Martin
D E
DE
University of California, San Diego.
Goldman
M P
MP
D000818:Animals; D004431:Ear, External / Q000098:blood supply*; D005233:Fatty Alcohols / Q000494:pharmacology*; D005355:Fibrosis / Q000139:chemically induced / Q000473:pathology; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012597:Sclerosing Solutions / Q000009:adverse effects / Q000494:pharmacology*; D012981:Sodium Tetradecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013927:Thrombosis / Q000139:chemically induced / Q000473:pathology; D013997:Time Factors; D014654:Vascular Patency; D014680:Veins / Q000187:drug effects* / Q000473:pathology
D005233:Fatty Alcohols; D012597:Sclerosing Solutions; D005990:Glycerol; D012981:Sodium Tetradecyl Sulfate