Inhibin immunoreactivity in gonadal and non-gonadal tumors.
Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions as a growth or differentiation factor.
De Jong
F H
FH
Department of Biochemistry, Division of Chemical Endocrinology, Erasmus University Rotterdam, The Netherlands.
Grootenhuis
A J
AJ
Steenbergen
J
J
van Sluijs
F J
FJ
Foekens
J A
JA
ten Kate
F J
FJ
Oosterhuis
J W
JW
Lamberts
S W
SW
Klijn
J G
JG
D000818:Animals; D014408:Biomarkers, Tumor; D004285:Dogs; D005260:Female; D006801:Humans; D007265:Inhibins / Q000276:immunology*; D008297:Male; D009928:Organ Specificity; D010051:Ovarian Neoplasms / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology*; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D007265:Inhibins