Standardized non-invasive assessment of myocardial free fatty acid kinetics by means of 15-(para-iodo-phenyl) pentadecanoic acid (123I-pPPA)scintigraphy: I. Method.
Two simple mathematical functions have been applied for estimating myocardial perfusion and fatty acid metabolism from planar, dynamic 123I-para-phenylpentadecanoic acid (123I-pPPA) studies. The first one uses a modified gamma function and the latter one a biexponential fit. The reciprocal of mean transit time is assumed to represent myocardial blood flow and the fast phase (size and half-time) of the biexponential fit primarily accounts for beta oxidation of 123I-pPPA.
Wieler
H
H
Department of Nuclear Medicine, Koblenz, FRG.
Kaiser
K P
KP
Frank
J
J
Kuikka
J T
JT
Ladwein
K
K
Winkens
A
A
D003326:Coronary Circulation; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging; D013997:Time Factors
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid