Application of thermospray liquid chromatography-mass spectrometry for the analysis of chloramphenicol and three related compounds.
The thermospray (TS) liquid chromatographic-mass spectrometric analysis of the antibiotic chloramphenicol and three related compounds is presented. The three additional compounds are dehydrochloramphenicol, aminodehydrochloramphenicol, and nitrophenylaminopropanediol. Baseline separation of the four compounds is achieved. The TS mass spectrum of each of the four compounds includes a prominent [MH]+ ion plus some fragment ion peaks.
Korfmacher
W A
WA
U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Getek
T A
TA
Hansen
E B
EB
Cerniglia
C E
CE
Abou-Khalil
S
S
Yunis
A A
AA
D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000032:analysis*; D002853:Chromatography, Liquid; D013058:Mass Spectrometry
C024061:1-(4'-nitrophenyl)-2-aminopropane-1,3-diol; C067222:aminodehydrochloramphenicol; C056132:dehydrochloramphenicol; D002701:Chloramphenicol