PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus.
We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.
Oberpichler
H
H
Institut für Pharmakologie und Toxikologie, Marburg, F.R.G.
Sauer
D
D
Rossberg
C
C
Mennel
H D
HD
Krieglstein
J
J
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes; D046934:Ginkgolides; D006624:Hippocampus / Q000473:pathology*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D009336:Necrosis; D009474:Neurons / Q000473:pathology*; D010936:Plant Extracts; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; C045856:ginkgolide B