[Primary myelodysplastic syndrome. Prognostic factors and frequent appearance of monoclonal and polyclonal gammopathies].
Prognostic factors were obtained by retrospective analysis of data on 44 patients (34 men and ten women; average age 64 +/- 13 years) with a primary myelodysplastic syndrome. The most important factors for a poor prognosis were the presence of more than 5% blast cells in the bone marrow (P = 0.001), serum platelet count of less than 150,000/microliters (P = 0.05), serum white cell count less than 3000/microliters (not significant) and serum lactate dehydrogenase concentration greater than 240 U/l (P = 0.05). Protein electrophoresis revealed a polyclonal hypergammaglobulinaemia in 15 of 38 patients; in eight of 17 patients with partly normal curve pattern at protein electrophoresis, a monoclonal gammopathy was demonstrated (monoclonal gradient 3.5 g/dl) by immunoelectrophoresis or immunofixation. No prognostic significance could be established for these gammopathies.
von Hirschhausen
R
R
Abteilung Innere Medizin II, Medizinische Klinik und Poliklinik der Universität Tübingen.
Saal
J G
JG
D000368:Aged; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000145:classification / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000401:mortality* / Q000473:pathology; D010265:Paraproteinemias / Q000145:classification / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
Primäres myelodysplastisches Syndrom. Prognostische Faktoren und gehäuftes Auftreten monoklonaler und polyklonaler Gammopathien.