[The effect of hemosorption on the indices of the structural-functional status of the erythrocyte membranes in arterial hypertension patients].
A study was made of the stability of the parameters of 2 membranous tests, used in the differential diagnosis of some forms of arterial hypertension, under the influence of hemoperfusion, an extracorporeal treatment method. One of these tests consists in the measurement of the Na-Li countertransport velocity across the erythrocytic membrane. It allows revealing functional disorders in ion transport across the cellular membranes. The second one involves the determination of monoclonal antibody (mon Ab) binding to the fragmented erythrocytic membranes. The test enables recording the structural changes that occur in the erythrocytic membranes. Before and after hemoperfusion the velocity of Na-Li countertransport was measured in 8 patients suffering from arterial hypertension whereas mon Ab binding to the fragmented erythrocytic membranes in 6 patients. After hemoperfusion all the patients manifested an increase of the velocity of Na-Li countertransport (by 15 to 108% as compared to the initial). On the other hand, after that procedure the patients with arterial hypertension did not demonstrate any appreciable alterations in mon Ab binding to the fragmented erythrocytic membranes. Thus, the membranous test (mon Ab binding to the fragmented erythrocytic membranes) reflecting the structural characteristics of the erythrocytic membrane appears more "rigid" and stable as compared to Na-Li countertransport reflecting the functional properties of the erythrocytic membrane, which, as it was to be expected, respond more readily to different external effects.
Eliseev
A O
AO
Loginov
V A
VA
Kukharchuk
V V
VV
D000911:Antibodies, Monoclonal / Q000097:blood; D001692:Biological Transport; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006464:Hemoperfusion; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000628:therapy*; D008094:Lithium / Q000097:blood; D012964:Sodium / Q000097:blood
D000911:Antibodies, Monoclonal; D008094:Lithium; D012964:Sodium
Vliianie gemosorbtsii na pokazateli strukturno-funktsional'nogo statusa membran éritrotsitov bol'nykh arterial'noĭ gipertonieĭ.