title: Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.
abstract: Topical 20% benzocaine (Hurricaine, Beutlich, Inc., Niles, Ill.) spray is frequently used for oral anesthesia before upper endoscopy. Side effects attributed to this agent are exceedingly rare. The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase deficiency. The mechanisms for the development of methemoglobinemia and its treatment are reviewed.
authors.affiliation: Portland Veterans Administration Medical Center, Oregon.
authors.forename: J F
authors.initials: JF
authors.lastname: Collins
mesh_terms: D000328:Adult; D000772:Anesthesia, Local; D001566:Benzocaine / Q000008:administration & dosage / Q000009:adverse effects*; D042966:Cytochrome-B(5) Reductase / Q000172:deficiency; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000235:genetics
chemical_list: D042966:Cytochrome-B(5) Reductase; D001566:Benzocaine