[Zinc-protoporphyrin determination in patients with sideropenic anemia and insufficient erythropoiesis].
We have measured erythrocyte Zinc-Protoporphyrin and serum ferritin in 125 subjects: 100 seemingly healthy controls, 17 with sideropenic anemia and 8 with erythropoietic insufficiency (sideropenia without anemia). Erythrocyte Zinc-Protoporphyrin was measured using Protofluor Z (Helena--Lab.) and serum ferritin was tested with immunoenzymatic technics. Patients with sideropenic anemia showed erythrocyte Zinc-Protoporphyrin values higher than controls, whereas serum ferritin was significantly lower than controls. Patients with erythropoietic insufficiency also showed erythrocyte Zinc-Protoporphyrin values higher than controls with statistical significance whereas the decrease of serum ferritin was not significant. Our study showed that Zinc-Protoporphyrin, in conjunction with serum ferritin, is a very useful test for evaluation of iron storage.
D'Angelo
G
G
Laboratorio di Analisi chimico-cliniche, Ematologia e Microbiologia, Presidio ospedaliero di Somma Lombardo, U.S.S.L. n. 6, Gallarate.
Giardini
C
C
Zanco
M D
MD
D000328:Adult; D000747:Anemia, Hypochromic / Q000097:blood* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004920:Erythropoiesis; D005293:Ferritins / Q000097:blood; D006801:Humans; D000090463:Iron Deficiencies; D011524:Protoporphyrins / Q000097:blood*; D015032:Zinc / Q000097:blood*
D011524:Protoporphyrins; D005293:Ferritins; D015032:Zinc
Dosaggio della zinco-protoporfirina in pazienti con anemia iposideremica ed eritropoiesi insufficiente.