Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin.
The in-vivo metabolic conversion of equal mixture of phenytoin and decadeuteriophenytoin to the para-hydroxy metabolite in rat was investigated in order to verify a possible role of an insertion or abstraction mechanisms in the hydroxylation process. Determination of kH/k2H values of urine samples at 2 h intervals for 24 h indicated that there was no isotope effect during in-vivo para-hydroxylation of phenytoin. This gives evidence of the arene oxide intermediacy possibly being the sole pathway for para-hydroxylation of phenytoin.
Moustafa
M A
MA
Department of Midicinal, Faculty of Pharmacy, University of Mansoura, Egypt.
el-Emam
A A
AA
Subbagh
H I
HI
el-Din
M K
MK
D000818:Animals; D003903:Deuterium; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D008297:Male; D010084:Oxidation-Reduction; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000378:metabolism*; D051381:Rats
C001419:hydroxyphenytoin; D010672:Phenytoin; D003903:Deuterium