title: Liver triglyceride accumulation after chronic ethanol administration: a possible protective role of metadoxina and ubiquinone.
abstract: Hepatoprotective actions of metadoxina and ubiquinone have been studied in alcoholic rats by evaluating hepatic triglyceride accumulation and serum biochemical parameters of liver function. The two drug-treated groups displayed significantly lower triglyceride concentrations as compared to the ethanol-treated group. No significant differences were found among the two drug-treated and the control groups. Electron-microscopic abnormalities were found only in ethanol-treated rats. Serum biochemical parameters of liver function did not show any significant difference among all four groups. These results suggest a possible protective role of metadoxina and ubiquinone in ethanol-induced liver triglyceride accumulation.
authors.affiliation: First Medical Clinic, University of Pisa, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Marchi
authors.forename: A
authors.initials: A
authors.lastname: Polloni
authors.forename: F
authors.initials: F
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Bellini
authors.forename: V
authors.initials: V
authors.lastname: Bonifazi
authors.forename: E
authors.initials: E
authors.lastname: Tumino
authors.forename: B
authors.initials: B
authors.lastname: Grassi
authors.forename: M R
authors.initials: MR
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: De Bartolo
authors.forename: A
authors.initials: A
authors.lastname: Bertelli
mesh_terms: D000818:Animals; D004338:Drug Combinations; D000431:Ethanol / Q000494:pharmacology*; D005234:Fatty Liver / Q000139:chemically induced / Q000517:prevention & control; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009994:Osmolar Concentration; D011736:Pyridoxine / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism*; D014451:Ubiquinone / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D014280:Triglycerides; D014451:Ubiquinone; D000431:Ethanol; C037845:metadoxine; D011736:Pyridoxine; D011761:Pyrrolidonecarboxylic Acid