[Alterations of the sympathetic activity, plasma catecholamine content and pulmonary surfactant in neurogenic pulmonary edema in rats].
Neurogenic pulmonary edema (NPE) was induced by microinjection of kainic acid into bilateral preoptic area (POA) of the hypothalamus in rats. Sympathetic discharge of the left adrenal branch was recorded, plasma catecholamine (CA) was assayed and the physical properties of pulmonary surfactant (PS) of the lung lavage were measured. The results showed that some physical properties of PS were changed in NPE, i.e. maximal surface tension (gamma Max) decreased, minimum surface tension (gamma Min) increased, recruitment index (RI), stability index and area of hysteresis loop (H-area) decreased. After injection of kainic acid into POA, the sympathetic discharge increased by 22.8 +/- 7.20% and 32.2 +/- 8.0% respectively at 30 and 60 min after injection and paralleled by a marked elevation of plasma catecholamine (CA). The results showed that PS activity had decreased at an early stage of NPE and the change of the plasma CA level was parallel to that of sympathetic discharge. It is suggested that generation of NPE may be related to some disorder of the autonomic nervous system at the level of hypothalamus, increase of sympathetic discharge, elevation of plasma CA level and fall of PS activity.
Chen
M Q
MQ
Department of Pathophysiology, Second Military Medical University, Shanghai.
Zhang
Y F
YF
Shi
Y M
YM
Yao
D F
DF
Zhong
J G
JG
D000818:Animals; D002395:Catecholamines / Q000097:blood*; D004594:Electrophysiology; D005260:Female; D007608:Kainic Acid; D008297:Male; D008845:Microinjections; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D002395:Catecholamines; D011663:Pulmonary Surfactants; D007608:Kainic Acid