title: Effect of anticalmodulin and antitubulin on LDL-receptor synthesis in aortic smooth muscle cells cultured in vitro.
abstract: Effect of trifluoperazine and colchicine on LDL-receptor synthesis in smooth muscle cells exposed to hypercholesterolemic medium in vitro have been studied. While trifluoperazine at 25 microM concentration caused stimulation of LDL-receptor synthesis, colchicine acted as a dose-dependent inhibitor of LDL-receptor synthesis. Thus calmodulin down regulates LDL-receptor synthesis independent of microtubular involvement.
authors.affiliation: Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: U
authors.initials: U
authors.lastname: Mehta
authors.forename: D
authors.initials: D
authors.lastname: Kaul
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D011973:Receptors, LDL / Q000096:biosynthesis* / Q000187:drug effects; D014268:Trifluoperazine / Q000494:pharmacology; D050257:Tubulin Modulators
chemical_list: D002147:Calmodulin; D011973:Receptors, LDL; D050257:Tubulin Modulators; D014268:Trifluoperazine; D003078:Colchicine