title: Urine pH variation dynamics in healthy individuals and stone formers.
abstract: Urine pH density distribution curves have been obtained in groups of patients with concrements of various chemical compositions. Quantitative regularities for mixing chemical compounds in the concrements established by the infrared spectroscopic method have been shown to agree with urine pH distribution density (in time). Potential physicochemical mechanisms for the revealed generality are considered. In particular, it is indicated that urine pH variations display in the first approximation buffer effect of the concrement components. A Fourier analysis of pH variations in the homogeneous urine of healthy individuals and in the systems of urine versus concrement as a time function has been made. Urine pH variations observed have been shown to be approximated by the superposition of harmonic vibrations with a range of frequencies multiple of the diurnal one. It has been found that a distinctly pronounced and complicated gamut of pH fluctuations over the entire physiological range of values (i.e. 4.5-8.5) is typical of healthy individuals in contrast to the stone formers.
authors.affiliation: Institute of Physical-Organic and Coal Chemistry, Ukrainian SSR Academy of Sciences, Donetsk.
authors.forename: V M
authors.initials: VM
authors.lastname: Bilobrov
authors.forename: A V
authors.initials: AV
authors.lastname: Chugaj
authors.forename: V I
authors.initials: VI
authors.lastname: Bessarabov
mesh_terms: D002940:Circadian Rhythm / Q000502:physiology; D005583:Fourier Analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000737:chemistry / Q000652:urine*; D007671:Kidney Concentrating Ability; D012016:Reference Values; D014556:Urine / Q000737:chemistry