title: Isolation and biosynthesis of 3 alpha-hydroxy-3,5-dihydromonacolin L.
abstract: 3 alpha-Hydroxy-3,5-dihydromonacolin L acid (acid form), a new compound related to monacolin K (mevinolin), was isolated from the culture broth of a strain of Monascus ruber. The structure of the compound was determined by a combination of physical techniques. 4a,5-Dihydromonacolin L was converted to 3 alpha-hydroxy-3,5-dihydromonacolin L by a cell-free extract of M. ruber in the presence of molecular oxygen. The results demonstrate that the former is the direct precursor in the biosynthesis of the latter.
authors.affiliation: Department of Applied Biological Sciences, Tokyo Noko University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: D
authors.initials: D
authors.lastname: Komagata
authors.forename: S
authors.initials: S
authors.lastname: Murakawa
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Endo
mesh_terms: D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009281:Naphthalenes; C067078:3-hydroxy-3,5-dihydromonacolin L