Treatment of clomipramine-induced anorgasmia with yohimbine: a case report.
Clomipramine (a tricyclic antidepressant with significant serotonin activity) causes a high incidence of anorgasmia. The authors describe the successful treatment of clomipramine-induced anorgasmia with yohimbine (an enhancer of norepinephrine activity) in a patient with obsessive compulsive disorder and major depression. The significance of this finding for the clinical management of antidepressant-induced sexual dysfunction and the impact of serotonergic-noradrenergic interaction on male sexual functioning are discussed.
Price
J
J
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0118.
Grunhaus
L J
LJ
D000328:Adult; D002997:Clomipramine / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D009948:Orgasm / Q000187:drug effects*; D010919:Placebos; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000188:drug therapy; D015016:Yohimbine / Q000627:therapeutic use*
D010919:Placebos; D015016:Yohimbine; D002997:Clomipramine