title: Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.
abstract: A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.
authors.affiliation: Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Obase
authors.forename: H
authors.initials: H
authors.lastname: Takai
authors.forename: M
authors.initials: M
authors.lastname: Teranishi
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D010793:Phthalazines; D014227:Triazines; C043388:phthalazine