[Study of protective properties of antigen-containing liposomes of different lipid composition in plague].
Immunization of animals with a liposomal capsular and major somatic antigen of a plague causative agent enhanced their protective effects against plague infection. Lipopolysaccharide incorporation into the lipid membrane resulted in an increased protective effect of antigen-containing liposomes, which may be related to the single delivery and interaction with immune-competent cells. Incorporation of phospholipids with high phase transfer temperature and positively charged stearylamine by the membrane facilitates the immunogenicity of agents.
Zakrevskiĭ
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Plekhanova
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D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D002784:Cholesterol / Q000737:chemistry; D006168:Guinea Pigs; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D010743:Phospholipids / Q000008:administration & dosage / Q000737:chemistry; D010930:Plague / Q000276:immunology / Q000517:prevention & control*; D010931:Plague Vaccine / Q000008:administration & dosage*; D014611:Vaccination / Q000379:methods*; D015010:Yersinia pestis / Q000276:immunology*
D000942:Antigens, Bacterial; D008055:Lipids; D008081:Liposomes; D010743:Phospholipids; D010931:Plague Vaccine; D002784:Cholesterol
Izuchenie protektivnykh svoĭstv antigensoderzhashchikh liposom razlichnogo lipidnogo sostava pri chume.