[Detection of thrombin-antithrombin complexes in hypercoagulability conditions. Analysis of 182 cases].
The detection of TATC may inform about the presence of thrombin generation and, and hence of a pre-thrombotic status. An ELISA test (Enzygnst TAT) has been developed here in order to evaluate the predictive role played by TATC, and it was applied on 182 patients who distributed in 14 with cirrhosis of the liver, 11 with sepsis, 17 with chronic arterial insufficiency, 55 with neoplasms, 9 with thrombosis, 15 in postoperative period, 15 with pneumonia, 16 with disseminated intravascular coagulation (DIC), 14 with multiple injuries and 16 with pancreatitis. TATC levels were significantly increased in all groups with regard to the control group. Patients with thrombosis, sepsis, multiple injuries, DIC and in the postoperative period showed especially high TATC figures. No correlation between TATC and fibrinogen, platelet count, activated partial thromboplastin time or prothrombin complex assay was found in the post-operative patient-group. It was concluded that TATC are a good indicator of hypercoagulability.
Zuazu-Jausoro
I
I
Servei d'Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona.
Borrell
M
M
Urrutia
T
T
Oliver
A
A
Montserrat
I
I
Mateo
J
J
Ribera
L
L
Fontcuberta
J
J
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis* / Q000276:immunology; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D001780:Blood Coagulation Tests; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000032:analysis*; D013923:Thromboembolism / Q000517:prevention & control
D000990:Antithrombin III; D013917:Thrombin
Detección de complejos trombina-antitrombina-III en estados de hipercoagulabilidad. Análisis de 182 casos.