Treatment of severe lichen planus with cyclosporine.
Two patients with severe chronic lichen planus were successfully treated with oral cyclosporine (6 mg/kg/day). A response was noted within 4 weeks, and complete clearing was achieved after 8 weeks of treatment. No significant adverse effect was noted. The patients have remained in remission 3 and 10 months after therapy, respectively. Clinical improvement was accompanied by significant reduction in the T cell infiltrate in the skin. Abnormal expression of keratinocyte intercellular adhesion molecule-1 (ICAM-1), which was present before therapy, became undetectable after 1 week of cyclosporine therapy, before any significant clinical and histologic change.
Ho
V C
VC
Department of Dermatology, University of Michigan, Ann Arbor.
Gupta
A K
AK
Ellis
C N
CN
Nickoloff
B J
BJ
Voorhees
J J
JJ
D000328:Adult; D015815:Cell Adhesion Molecules / Q000032:analysis; D002908:Chronic Disease; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D008010:Lichen Planus / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013601:T-Lymphocytes / Q000473:pathology
D015815:Cell Adhesion Molecules; D003524:Cyclosporins; D006684:HLA-DR Antigens