title: An avian model for the study of acute hemolytic anemia in the domestic fowl (Gallus domesticus).
abstract: Acute hemolytic anemia was experimentally induced in chickens with the oxidant chemical phenylhydrazine. From results of the graded doses trial, subcutaneously injected 6 mg/100 g body weight single dose was designated as standardised. The anemic response, characterized by marked reductions in hemoglobin, packed cell volume and total erythrocyte count, was perceptible on day 1 post-injection. Peak anemia was observed on day 3. Compensatory erythropoiesis was discernible on day 5. The hematological profile indicated near complete recovery on day 11 post-injection. This avian model is proposed for study of the basic mechanisms of hemolytic anemia in chickens.
authors.affiliation: Department of Medicine, College of Veterinary Science and Animal Husbandry, Jabalpur, India.
authors.forename: K
authors.initials: K
authors.lastname: Datta
authors.forename: J L
authors.initials: JL
authors.lastname: Soni
authors.forename: I C
authors.initials: IC
authors.lastname: Datta
mesh_terms: D000208:Acute Disease; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004906:Erythrocyte Count; D007279:Injections, Subcutaneous; D010659:Phenylhydrazines; D011201:Poultry Diseases / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D010659:Phenylhydrazines; C030299:phenylhydrazine