Fusidic acid treatment of HIV infection: no significant effect in a pilot trial.
22 HIV-positive homosexual men were treated with fusidic acid tablets (500 mg t.i.d.) for a period of 2-12 months (mean 71/2). At entry, all had a CD4-count less than 500 X 10(6)/l, and/or a pokeweed mitogen lymphocyte proliferation response of less than 50% of 2 normal controls, and no overt opportunistic infections. No significant immunological changes were observed and no definite beneficial clinical effect. On the 10th-13th day of treatment, 12 of the patients developed fever and an itchy exanthema. The symptoms disappeared spontaneously in 9 patients. No hematological or biochemical side effects were seen. Thus, in this pilot study of fusidic acid therapy of HIV-infected men, no significant effect could be detected.
Hørding
M
M
Department of Infectious Diseases, AIDS laboratory M 7705, Rigshospitalet, Copenhagen, Denmark.
Christensen
K C
KC
Faber
V
V
D005672:Fusidic Acid / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000188:drug therapy; D006801:Humans; D008297:Male; D010865:Pilot Projects
D005672:Fusidic Acid