Changes in auditory function associated with 2-cyano-butyl-acrylate adhesive implanted in the middle ear of experimental animals.
The effects on auditory function caused by the implantation of 2-cyano-butyl-acrylate adhesive in the middle ear was investigated in experimental animals. Auditory brainstem responses to click stimuli were used to measure hearing thresholds prior to and following implantation of 2-cyano-butyl-acrylate adhesive in the middle ear of guinea pigs. A permanent and deep threshold shift observed at 2 months in 62% of the examined animals, suggested that this tissue adhesive is an ototoxic middle ear implant material and should not be considered in reconstructive middle ear surgery. The functional data correlate well with some of the previous morphological observations.
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Department of Otolaryngology, Sourasky Medical Center, Sackler School of Medicine, University of Tel Aviv, Israel.
Rapoport
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Himelfarb
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MZ
D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000187:drug effects; D004432:Ear, Middle; D004659:Enbucrilate / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*
D004659:Enbucrilate