Development of enolase isoenzymes in various regions of the human brain.
Various brain regions from 4 fetuses (21st to 28th gestational week) and from a 3-month-old infant were investigated for the total enolase activity and their isoenzyme distribution. In the brain tissue from a 3-month-old infant, the activity of the so-called neuron-specific enolase amounted to about 50% of the total enolase activity. In various brain regions different developmental patterns emerged for nonneuronal (NNE) and neuron-specific enolase (NSE). By the 21st gestational week the medulla, pons and thalamus had already reached a relatively high NSE activity (about 60-90% of that of the 3-month values), whereas the cortex regions had 10-30% only. It is concluded that in phylogenetically old regions, the switch from NNE to NSE-subunits appears before the 21st gestational week, in the phylogenetically young regions between the 21st and 28th gestational week.
Gross
J
J
Institute of Pathological and Clinical Biochemistry, Humboldt University, Charité Hospital, Berlin, GDR.
Zinsmeyer
J
J
Lessing
A
A
Wenzel
J
J
Prenzlau
P
P
Halle
H
H
Grauel
E L
EL
D001921:Brain / Q000196:embryology / Q000201:enzymology*; D005333:Fetus; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*
D007527:Isoenzymes; D010751:Phosphopyruvate Hydratase