title: Cataract-related changes in protein aggregates of human lens studied by ultracentrifugation.
abstract: In human lens, cataract development causes an increase in the amount of protein aggregates. Their specific density of 1.25 g/ml is much higher than that of 1.14 g/ml and 1.06 g/ml obtained for water-soluble proteins. During the formation of water-insoluble aggregates their size varies up to some micrometers. Infrared spectra of water-soluble protein and in the aggregates confirm that the content of bound water in aggregates decreases.
authors.affiliation: Laboratory for Biostructural Research, Jagiellonian University, Cracow.
authors.forename: J
authors.initials: J
authors.lastname: Twardowski
authors.forename: D
authors.initials: D
authors.lastname: Hoja
mesh_terms: D000368:Aged; D002386:Cataract / Q000378:metabolism*; D002499:Centrifugation, Density Gradient / Q000379:methods; D003459:Crystallins / Q000032:analysis*; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry*; D008970:Molecular Weight; D012995:Solubility; D013046:Specific Gravity
chemical_list: D003459:Crystallins