title: Computerized tomography of brain in infantile spasms (West syndrome).
abstract: Computerized tomographic scanning of the brain was performed in 26 infants with Infantile spasms. Majority of the patients, 18 (69%) had some abnormality. Changes noted were cerebral atrophy in 12, calcifications in 5 and dysgenesis of the corpus callosum in 3 patients. One infant each had porencephaly, hydrocephalus and cavum septum pellucidum. Five patients had more than one abnormality simultaneously. Three infants had progressively worsening atrophy on ACTH therapy. Patients with infantile spasms, without any physical or neurological abnormality, are unlikely to have any abnormalities on brain CT scanning (p = less than 0.005).
authors.affiliation: Department of Paediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: Mahdi
authors.forename: M D
authors.initials: MD
authors.lastname: Yohannan
authors.forename: P J
authors.initials: PJ
authors.lastname: Patel
authors.forename: T M
authors.initials: TM
authors.lastname: Malabarey
authors.forename: T M
authors.initials: TM
authors.lastname: Kolawole
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012529:Saudi Arabia / Q000453:epidemiology; D013036:Spasms, Infantile / Q000000981:diagnostic imaging* / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000453:epidemiology