title: [Clinical and laboratory studies in patients with pulmonary tuberculosis treated with pyrazinamide].
abstract: Different combinations of tuberculostatic drugs containing pyrazinamide were prescribed to 144 patients with pulmonary tuberculosis. In 3 months of treatment, bacterial excretion was observed in 89.7% of newly diagnosed patients and in 59% of cases with chronic forms of pulmonary tuberculosis. Side effects due to pyrazinamide were registered in 16.8% of the patients. In 2-3 months of therapy there were no differences traced in the condition of the liver, lipoid peroxidation or antioxidative activity as well as in a number of immunologic indices both in subjects receiving different combinations of antituberculous drugs, containing pyrazinamide, and in the control group of patients untreated with the drug.
authors.forename: M M
authors.initials: MM
authors.lastname: Savula
authors.forename: M I
authors.initials: MI
authors.lastname: Smolenko
authors.forename: M D
authors.initials: MD
authors.lastname: Romaniuk
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Slivka
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide
vernacular_title: Klinicheskie i laboratornye issledovaniia u bol'nykh tuberkulezom legkikh, lechennykh pirazinamidom.