title: Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain.
abstract: The regional distribution of insulin-like growth factor I (IGF-I) was examined in the tissue and extracellular compartment of rat brain. The tissue content of IGF-I was the highest in the pituitary gland, followed by the olfactory bulb, upper brainstem, cerebellum, striatum, hippocampus, lower brainstem, and cerebral cortex. The extracellular concentration was studied by intracerebral microdialysis technique, and the highest content was found in the hippocampus, followed by the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. The tissue and extracellular contents were significantly correlated in the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. IGF-I might act by paracrine and/or autocrine regulatory mechanisms in these regions.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical School, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Itano
authors.forename: M
authors.initials: M
authors.lastname: Mizobuchi
authors.forename: O
authors.initials: O
authors.lastname: Miyamoto
authors.forename: N A
authors.initials: NA
authors.lastname: Janjua
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Tokuda
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
authors.forename: K
authors.initials: K
authors.lastname: Hosokawa
authors.forename: O
authors.initials: O
authors.lastname: Hatase
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D003956:Dialysis; D005110:Extracellular Space / Q000737:chemistry*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007334:Insulin-Like Growth Factor I