Lipoprotein particles in homozygous familial hypercholesterolemic patients treated with portacaval shunt and LDL apheresis.
Lipoprotein particles containing apolipoproteins (Apo) were studied by enzyme-linked-immunosorbent assay in two homozygous familial hypercholesterolemic patients (1 male and 1 female) with portacaval shunts, and in controls. Total Apo B, total cholesterol and LDL cholesterol were increased in both patients while complex Apo B containing particles, Lp CIII: B, were not increased in these FH patients. The dextran-sulfate cellulose columns (Liposorber LA-40) had an excellent adsorption selectivity and adsorption capacity for lipoprotein particles containing Apo B and a minimum adsorption capacity in Apo AI and Apo AII-containing particles. This apheresis technique selectively depleted plasma of atherogenic Apo B-containing particles with a minimal loss of antiatherogenic Apo AI-containing particles.
Gairin
D
D
Service de Néphrologie, CHU Lille, France.
Monard
F
F
Cachera
C
C
Bard
J M
JM
Amouyel
P
P
Duriez
P
P
Tacquet
A
A
Fruchart
J C
JC
D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001781:Blood Component Removal; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000628:therapy*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011167:Portacaval Shunt, Surgical; D013997:Time Factors
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins