[The significance of serum fructosamine measurement in patients with thyroid diseases].
Serum fructosamine was measured in patients with Graves' disease and primary hypothyroidism. Fructosamine levels and fructosamine per albumin ratio were significantly lower in patients with Graves' disease than in normal subjects, while they were significantly higher in patients with primary hypothyroidism. Fructosamine levels were normalized by treatment in the euthyroid state in patients with Graves' disease. Along with the normalization of thyroid stimulating hormone levels, fructosamine levels returned to the normal range in patients with primary hypothyroidism with treatment. There were significant correlations between fructosamine levels and free triiodothyronine levels, free thyroxine levels, thyroid stimulating hormone levels, hemoglobin A1C levels, albumin levels, and creatine phosphokinase levels. We concluded that it was useful to measure serum fructosamine as an indicator of peripheral metabolic function in patients with thyroid diseases.
Hara
H
H
Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Ban
Y
Y
Taniyama
M
M
Sato
R
R
Kushima
K
K
Nagakura
H
H
Kaihara
M
M
Ito
K
K
D003402:Creatine Kinase / Q000097:blood; D005260:Female; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000378:metabolism; D006111:Graves Disease / Q000097:blood; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism; D013959:Thyroid Diseases / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D003402:Creatine Kinase; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D012709:Serum Albumin; D013972:Thyrotropin; D013974:Thyroxine; D014284:Triiodothyronine