[Effects of N-propylajmaline bromide and trimecaine combination on normal and abnormal automatism of Purkinje fibers in dogs and arrhythmias at the late stage of experimental myocardial infarct].
Prajmalium bromide in combination with trimecaine was tested for effects on arrhythmias in the late period of canine experimental myocardial infarction. The combination given in subthreshold doses was found to restore sinus rhythm in 8 of 11 cases. It also decreased the maximum repolarization rate in rat papillary muscles to a greater extent than either drug given alone. The rate of spontaneous firing of Purkinje fibers from the ischemic zone was decreased by the combination of the drugs.
Balashov
V P
VP
Kostin
Ia V
IaV
Sosunov
E A
EA
Gendenshteĭn
E I
EI
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004285:Dogs; D004359:Drug Therapy, Combination; D009203:Myocardial Infarction / Q000150:complications*; D010210:Papillary Muscles / Q000187:drug effects; D011219:Prajmaline / Q000008:administration & dosage* / Q000494:pharmacology; D011690:Purkinje Fibers / Q000187:drug effects*; D014288:Trimecaine / Q000008:administration & dosage* / Q000494:pharmacology
D011219:Prajmaline; D014288:Trimecaine
Deĭstvie kombinatsii N-propilaĭmalinbromida i trimekaina na normal'nuiu i anomal'nuiu avtomatiiu volokon Purkin'e sobaki i aritmii na pozdneĭ stadii éksperimental'nogo infarkta miokarda.