title: Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence.
abstract: The inability of schizophrenics to filter irrelevant information has often been implicated in the psychopathology of schizophrenia. Despite numerous attempts at characterizing the behavior of schizophrenics in the presence of distractors, evidence of increased distractibility has been equivocal due to the difficulty of assessing simultaneously the behavioral and neurophysiological effects of distracting stimuli. We report the results of an experiment in which event-related potential and performance measures were used to assess distractibility during reaction time tasks under different distracting conditions. The results supported the view of an increased distractibility in schizophrenic patients. Event-related potential data suggested that in schizophrenic patients, a reduced amount of processing resources is allocated to process external stimuli and attention is abnormally apportioned to task-irrelevant vs task-relevant stimuli.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510-3223.
authors.forename: C
authors.initials: C
authors.lastname: Grillon
authors.forename: E
authors.initials: E
authors.lastname: Courchesne
authors.forename: R
authors.initials: R
authors.lastname: Ameli
authors.forename: M A
authors.initials: MA
authors.lastname: Geyer
authors.forename: D L
authors.initials: DL
authors.lastname: Braff
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology