The effect of photochemotherapy with 4,4',6 trimethylangelicin on murine cutaneous immune cells.
The effect of photochemotherapy with 4,4',6 trimethylangelicin (TMA), a new monofunctional furocoumarin with a high antiproliferative activity, was studied on murine dendritic epidermal cells. Female mice (C3H/HeN[MTV-]) were treated topically with the drug three times a week for 4 consecutive weeks followed each time by 1 J/cm2 of UVA radiation. At the end of the treatment almost total depletion of ATPase+, Ia+ and Thy-1+ dendritic epidermal cells was observed, associated with marked hyperpigmentation but no gross or microscopic phototoxicity. Although 4,4',6 TMA is not phototoxic in mice, it affects the cutaneous immune cells.
Alcalay
J
J
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Dall'Acqua
F
F
Kripke
M L
ML
D000818:Animals; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D005260:Female; D011564:Furocoumarins / Q000494:pharmacology*; D051379:Mice; D010778:Photochemotherapy / Q000009:adverse effects; D012867:Skin / Q000187:drug effects* / Q000276:immunology; D012880:Skin Pigmentation / Q000187:drug effects
D011564:Furocoumarins; C041621:4,4',6-trimethylangelicin