title: Amyotrophic lateral sclerosis in a patient with fragile X syndrome.
abstract: Fragile X syndrome is a common cause of mental retardation. We report the clinical and pathologic features of a patient with fragile X syndrome who developed amyotrophic lateral sclerosis (ALS) at a relatively young age. Although the occurrence of these 2 diseases could be a mere coincidence, the development of ALS in this patient might be related to the chromosomal aberration of fragile X syndrome.
authors.affiliation: Department of Neurology, University Hospital, Saskatoon, Saskatchewan, Canada.
authors.forename: H B
authors.initials: HB
authors.lastname: Desai
authors.forename: J
authors.initials: J
authors.lastname: Donat
authors.forename: M H
authors.initials: MH
authors.lastname: Shokeir
authors.forename: D G
authors.initials: DG
authors.lastname: Munoz
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology*; D001921:Brain / Q000473:pathology; D005600:Fragile X Syndrome / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D012729:Sex Chromosome Aberrations / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology