The modulating influence of enkephalins on the bone marrow haemopoiesis in stress.
The influence of enkephalins on haemopoiesis was studied under conditions of stress. Administration of leu-enkephalin and dalargin to mice subjected to immobilization led to inhibition of proliferation and differentiation of haemopoietic precursor cells and to a reduction in the content of cellular elements of erythroid and granulocyte lineages of haemopoiesis. On the contrary, met-enkephalin produced a stimulating influence on the bone marrow haemopoiesis in stress. The regulatory influence of enkephalins is connected with reduction of glucocorticoid production and inhibition of migration to bone marrow of T-lymphocyte regulators of haemopoiesis of the phenotype Lyt-1+, Lyt-2+ and with the direct action on the bone marrow cells. Participation of endogenous leu-enkephalin in the haemopoiesis regulation in stress takes place at an early stage (the first 24 h) of the general adaptation syndrome formation.
Goldberg
E D
ED
Laboratory of Pathophysiology, Research Institute of Tomsk, Scientific Centre of the USSR Academy of Medical Sciences.
Dygai
A M
AM
Zakharova
O
O
Shakhov
V P
VP
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000502:physiology; D002452:Cell Count / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010649:Phenylalanine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012149:Restraint, Physical / Q000379:methods; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D009270:Naloxone; D010649:Phenylalanine; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine