title: Improvement of action myoclonus by an administration of 5-hydroxytryptophan and carbidopa in a child with muscular subsarcolemmal hyperactivity.
abstract: We report a 3-year-11-month-old boy who manifested action myoclonus only. Histochemical analysis of the quadriceps muscle revealed subsarcolemmal hyperactivity. The administration of 5-hydroxytryptophan and carbidopa dramatically improved the action myoclonus and reduced an amplitude of giant somatosensory evoked potentials. A nosological relation of this case with "essential myoclonus" and mitochondrial encephalomyopathy was discussed.
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Shishikura
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009207:Myoclonus / Q000188:drug therapy* / Q000209:etiology
chemical_list: D006916:5-Hydroxytryptophan; D002230:Carbidopa