title: On the kinetics of suicide substrates.
abstract: We consider a realistic suicide substrate reaction which can be represented by four rate equations for the concentrations of the various molecules as functions of time. We present a general procedure to obtain accurate, approximate solutions analytically in terms of the rate equation parameters. This systematic technique provides more accurate approximations to the exact (numerical) solutions than other approximate methods which have been proposed based on a pseudo-steady state hypothesis.
authors.affiliation: Centre for Mathematical Biology, Mathematical Institute, Oxford, U.K.
authors.forename: M A
authors.initials: MA
authors.lastname: Burke
authors.forename: P K
authors.initials: PK
authors.lastname: Maini
authors.forename: J D
authors.initials: JD
authors.lastname: Murray
mesh_terms: D004791:Enzyme Inhibitors; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D011485:Protein Binding
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes