[Anti-elastin antibodies in systemic lupus erythematosus].
Immunological response to elastin-derived peptides may cause tissue damage with subsequent degradation of the elastic fibres. Therefore, an incidence of anti-elastin antibodies in sera of patients with the systemic lupus erythematosus was studied. Sixty sera from 50 patients with systemic lupus erythematosus and 50 healthy subjects were assayed with dot-immunobinding technique. Titre 1:10 was considered diagnostically significant. Anti-elastin antibodies were diagnosed in 19 patients (31%) where as they were absent in the control group. In all cases anti-elastin antibodies were IgG.
Gmiński
J
J
Katedry i Zakładu Biochemii i Chemii, AM.
Poborski
W
W
Kasprzak
A
A
Drózdz
M
M
Kardaszewicz
E
E
Machalski
M
M
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D004549:Elastin / Q000276:immunology*; D005260:Female; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004549:Elastin
Przeciwciała przeciwelastynowe w toczniu rumieniowatym układowym.