Estimating familial effects on age at onset and liability to schizophrenia. II. Adjustment for censored data.
Genetic studies of disorders with adult onset often contain individuals who have not completed their age at risk when last observed. Without correction for such censoring, correlation in ages at onset among relatives is substantially underestimated. Moreover, without correction for the effect of correlated ages at onset, the relationship between age at onset in the proband and liability in relatives is substantially overestimated. The present paper describes methods for correcting the effects of censoring on these estimates. In a companion paper [Kendler and MacLean, Genet Epidemiol 7:409-417, 1990] these methods are applied to a large family study of schizophrenia.
MacLean
C J
CJ
Department of Psychiatry, Medical College of Virginia, Richmond 23298.
Neale
M C
MC
Meyer
J M
JM
Kendler
K S
KS
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011336:Probability; D012044:Regression Analysis; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D016019:Survival Analysis