[Morphofunctional state of alveolar macrophages after administration of ethanol].
In white non-inbred female rats, that were regularly given ethanol with drinking water in concentration 100 g/l for 2, 5 and 10 months, functional state of the pulmonary alveolar macrophages has been analyzed, using cytological, cytochemical and electron microscopical methods. In two months their functional activity is inhibited, and in 5 and 10 months--activation is observed, that results not only in formation of certain protective reactions in the lungs, but facilitates development of certain pathological processes in the organ.
Litvinov
N N
NN
Gasimova
Z M
ZM
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D000431:Ethanol
Morfofunktsional'noe sostoianie al'veoliarnykh makrofagov legkikh pri vozdeĭstvii étanola.