title: Macromastia in a woman treated with penicillamine and oral contraceptives. A case report.
abstract: A patient with Wilson's disease treated with penicillamine developed severe hirsutism. After treatment with oral contraceptives, her breasts enlarged rapidly, and she experienced cyclic mastodynia. Around the time of her breast enlargement she also developed gingival hyperplasia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida.
authors.forename: B I
authors.initials: BI
authors.lastname: Rose
authors.forename: W J
authors.initials: WJ
authors.lastname: LeMaire
authors.forename: L J
authors.initials: LJ
authors.lastname: Jeffers
mesh_terms: D000328:Adult; D001940:Breast / Q000187:drug effects* / Q000473:pathology; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000627:therapeutic use; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006628:Hirsutism / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D009640:Norethindrone / Q000009:adverse effects / Q000627:therapeutic use; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; C020416:norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination; D004997:Ethinyl Estradiol; D010396:Penicillamine; D009640:Norethindrone