[The effect of prostenon on the pressor and depressor humoral systems in patients with resistant arterial hypertension].
After ineffective combined drug therapy patients with the resistant patterns of arterial hypertension were given 3 to 5 intravenous injections of prostenon (prostaglandin E2) in the total dose 3-5 mg. Prostenon was noted to produce a lasting hypotensive effect in patients with resistant essential hypertension and parenchymatous renal hypertension. The patients manifested favourable changes in the general clinical symptomatology. The antihypertensive effect of prostenon was related to appreciable activation of depressor humoral factors, with activation of pressor humoral factors being less remarkable.
Zeĭnalov
F M
FM
Vasil'ev
Iu M
IuM
Volos
B E
BE
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000097:blood; D015232:Dinoprostone / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007262:Infusions, Intravenous; D016234:Kallikrein-Kinin System / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone
Vliianie prostenona na pressornye i depressornye gumoral'nye sistemy u bol'nykh rezistentnoĭ arterial'noĭ gipertonieĭ.