Effect of thyroid deficiency on actin mRNA content in the developing rat cerebellum.
The actin mRNA content of the cerebellum was determined in normal and hypothyroid developing rats using RNA dot hybridization with a beta-actin cDNA probe. The decline in actin mRNA content occurring during the second postnatal week in normal development was delayed by about 1 week in hypothyroid rats. Since this effect coincides exactly with the delay in actin filament formation recently reported in thyroid-deficient rats, it strengthens the hypothesis of an inverse relationship in the developing brain between the polymerization state of actin and the production of actin mRNA.
Faivre-Sarrailh
C
C
CNRS URA 1197, Université des Sciences et Techniques du Languedoc, Montpellier, France.
Ferraz
C
C
Liautard
J P
JP
Rabié
A
A
D000199:Actins / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000199:Actins; D012333:RNA, Messenger