[Studies on the production of epidermal cytokines after UVB irradiation in patients with epidermodysplasia verruciformis].
The production of interleukin-1 (IL-1) and interleukin-1 inhibitor by keratinocytes isolated from the skin of epidermodysplasia verruciformis patients was studied. Keratinocytes from uninvolved skin of patients with most pronounced neoplastic lesions produced large amounts of an IL-1 inhibitor (20-40 kD). Keratinocytes from preneoplastic lesions showed no significant differences compared to cells from healthy donors but their production of IL-1 after UVB irradiation was increased.
Majewski
S
S
Kliniki Dermatologicznej AM w Warszawie.
Malejczyk
J
J
Urbanski
A
A
Schwarz
T
T
Malejczyk
M
M
Misiewicz
J
J
Rudnicka
L
L
Szymańczyk
J
J
Luger
T A
TA
Jabłońska
S
S
D000328:Adult; D004819:Epidermodysplasia Verruciformis / Q000378:metabolism* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D015603:Keratinocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism*; D014467:Ultraviolet Therapy
D007375:Interleukin-1
Badania nad produkcja cytokin naskórkowych pod wpływem UVB u chorych z epidermodysplasia verruciformis.