[The modelling of the development of Plasmodium yoelli yoelli in different vertebrate hosts].
Outbred mice and inbred BALB/c mice were used for simulating Plasmodium yoelii yoelii (strain 265 BY) development. When the infection is initiated by standardized blood cryosamples and in sporozoite infection in various vertebral hosts the infection develops likewise as regard to parasitemia cyclic recurrences, however, the magnitude of parasitemia peaks, time of their occurrence, its stabilization or attenuation are different, which to a great extent determines the period of gametocyte infectivity. Reproducibility of the models developed is ensured by the use of the same agent strain and host species, standardization of the inoculum type and the following characteristics of the vertebral host: sex, age, source and route of infection, chronobiology of schizogony and gametogony (quantitative and qualitative characteristics), duration of the infection (including a prepatent period) and the number of development peaks. An optimal model of the infection is merozoite infection of mice, when the first peak of gametocytemia is achieved during moderately increased parasitemia, prior to the parasitemia peak. The absence of marked interactions in asexual and sexual development of the parasite, and the coincidence of the parasitemia and gametocytemia peaks (infection models in BALB/c mice and sporozoite infection in mice) restrict substantially model standardization and selection of donors for infecting the carriers.
Amanmuradov
A Kh
AKh
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006790:Host-Parasite Interactions; D008288:Malaria / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010967:Plasmodium yoelii / Q000254:growth & development*; D013997:Time Factors
Modelirovanie razvitiia Plasmodium yoelii yoelii v raznykh pozvonochnykh khoziaev.