title: Optic nerve degeneration caused by supraophthalmic carotid artery infusion with cisplatin and ACNU. Case report.
abstract: A 28-year-old woman with a left frontoparietal anaplastic astrocytoma was treated postoperatively with a combination of cisplatin and 1-(4-amino-2-methylpyrimidine-5-yl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The drugs were infused via the left supraophthalmic internal carotid artery in an attempt to avoid ocular toxicity. The patient subsequently developed blindness in the left eye and a right temporal hemianopsia from marked degeneration of the left optic nerve and tract. It is apparent that the placement of a catheter into the supraophthalmic carotid artery does not exclude visual complications.
authors.affiliation: Department of Neurological Surgery, Kobe West Municipal Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shimamura
authors.forename: M
authors.initials: M
authors.lastname: Chikama
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: A
authors.initials: A
authors.lastname: Tsutsumi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001254:Astrocytoma / Q000188:drug therapy; D001766:Blindness / Q000139:chemically induced; D001932:Brain Neoplasms / Q000188:drug therapy; D002343:Carotid Artery, Internal; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006423:Hemianopsia / Q000139:chemically induced; D006801:Humans; D007261:Infusions, Intra-Arterial; D009410:Nerve Degeneration / Q000187:drug effects; D015376:Nimustine / Q000008:administration & dosage / Q000009:adverse effects*; D009880:Ophthalmic Artery; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D015376:Nimustine; D002945:Cisplatin