Plasma lipid-bound sialic acid alterations in neoplastic diseases.
Plasma lipid-bound sialic acid (LSA) was assayed in normal volunteers, patients with non-malignant diseases, and a variety of cancer patients. Mean plasma LSA in 50 normal volunteers, 16 patients with non-malignant diseases, 54 breast cancer, 17 lung cancer, 15 colon cancer, 7 ovarian cancer, 5 prostate cancer, 4 leukemia, 4 gastrointestinal, 3 thyroid cancer, 3 pancreas cancer and 2 adrenal cancer patients were 17.7, 23.2, 58, 85, 56.7, 46.2, 56.7, 53.3, 31.1, 33.2 and 119.5 mg/dl, respectively. None of the normal volunteers had elevated plasma LSA values. Plasma LSA level was not significantly different in male and female volunteers. Two out of 114 different cancer patients had plasma LSA levels within normal range exhibiting 98.2% sensitivity of the assay. Plasma LSA, which is relatively simple to assay, may be used as a tumor marker in wide variety of neoplastic diseases.
Dwivedi
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Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings 57007.
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D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D019158:N-Acetylneuraminic Acid; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood*; D012016:Reference Values; D012794:Sialic Acids / Q000097:blood*
D014408:Biomarkers, Tumor; D008055:Lipids; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid