Cytolethal distending toxin (CLDT) production by enteropathogenic Escherichia coli (EPEC).
Culture supernates of 16 strains of EPEC belonging to 6 different serogroups, when assayed on Chinese Hamster Ovary (CHO) cells up to 96-120 h, induced distinct morphological changes. The supernate activities were heat-labile, unrelated to heat-labile enterotoxin (LT), verotoxin (VT), or hemolysin, did not show necrosis in rabbit skin and caused no fluid secretion in the rabbit ileal loop assay (RILA). Simultaneous production of CLDT and heat-stable enterotoxin (ST) were detected in four EPEC strains.
Bouzari
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S
Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
Varghese
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A
D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000633:toxicity; D002455:Cell Division; D002460:Cell Line; D004768:Enterotoxins / Q000096:biosynthesis; D004926:Escherichia coli / Q000378:metabolism* / Q000472:pathogenicity; D029968:Escherichia coli Proteins; D006358:Hot Temperature
D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C067044:cytolethal distending toxin; C034151:heat stable toxin (E coli)