title: Decreased in vitro susceptibility to zidovudine of HIV isolates obtained from patients with AIDS.
abstract: This study tested isolates of human immunodeficiency virus, obtained before and after zidovudine therapy from 10 patients, for susceptibility to the drug in vitro. The isolates collected after therapy were less susceptible to zidovudine as assessed by replication in MT-2 cells and production of reverse transcriptase activity by infected mononuclear leucocytes in the presence of the drug. Furthermore, pretherapy isolates were sensitive to a range of zidovudine concentrations when 100% inhibition was used as the end point. The loss of zidovudine susceptibility did not correlate with any clinical or virologic consequences in this small group of patients.
authors.affiliation: Virology Department, Fairfield Hospital, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Land
authors.forename: G
authors.initials: G
authors.lastname: Terloar
authors.forename: D
authors.initials: D
authors.lastname: McPhee
authors.forename: C
authors.initials: C
authors.lastname: Birch
authors.forename: R
authors.initials: R
authors.lastname: Doherty
authors.forename: D
authors.initials: D
authors.lastname: Cooper
authors.forename: I
authors.initials: I
authors.lastname: Gust
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000382:microbiology; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D015215:Zidovudine