title: [Alclometasone dipropionate (Legederm) for the treatment of steroid-sensitive dermatoses in the elderly].
abstract: This is a randomized single blind parallel comparison of alclometasone dipropionate cream 0.1% vs hydrocortisone butyrrate in 39 geriatric patients (greater than 60 years old) with steroid sensible skin diseases. The regimen consisted of dosing patients with two applications of the two drugs every day for 4 weeks. Follow-up evaluations have been done weekly, and subjective and objective clinical symptoms, adherence to the study protocol, evolution of the disease, onset of adverse reactions including atrophy have been recorded. Furthermore possible side-effects on hypophysis-adrenal axis have been monitored in baseline conditions, after 7 days and at the end of therapy. In most patients bioptic skin patterns for histomorphometric examination have been drawn before and after therapy to be evaluated by a blind examinator. Alclometasone has reduced initial skin lesions by 82.2%, the extent as hydrocortisone butyrrate. In five patients the complete clearance of the disease has been obtained. Study drugs have been tolerated well by all patients, nor clinical signs of atrophy have been observed. Fluctuations of blood cortisol levels ranged between the normal values. In patients treated with alclometasone histomorphometry revealed a better skin trophism than in patients treated with hydrocortisone butyrrate.
authors.affiliation: INRCA, Istituto a Carattere Scientifico, Ancona.
authors.forename: A
authors.initials: A
authors.lastname: Morresi
authors.forename: M
authors.initials: M
authors.lastname: Simonacci
authors.forename: G
authors.initials: G
authors.lastname: Mozzicafreddo
authors.forename: A
authors.initials: A
authors.lastname: Giacchetti
authors.forename: P
authors.initials: P
authors.lastname: Criante
authors.forename: V
authors.initials: V
authors.lastname: Mambelli
authors.forename: S
authors.initials: S
authors.lastname: Sisti
authors.forename: E
authors.initials: E
authors.lastname: Marchesi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016037:Single-Blind Method; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; C007975:hydrocortisone-17-butyrate; C021137:alclometasone dipropionate; D006854:Hydrocortisone; D008775:Methylprednisolone
vernacular_title: Alclometasone dipropionato (Legederm) nel trattamento delle dermatosi steroido-sensibili dell'anziano.