title: Histopathological changes in gastrocnemius muscles of rabbits injected with HI-6 in saline.
abstract: The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7. However, histopathological examinations disclosed lesions on some animals but with evidence of healing processes by Day 7; lesions disappeared by Day 14. Further macroscopic and histopathological examinations revealed that lesions associated with the high dose (200 mg/kg) were still prominent on Day 14 but with evidence of healing. Similar lesions seen in muscles injected with saline were significantly less persistent than those associated with HI-6.
authors.affiliation: Defence Research Establishment Suffield, Alberta, Canada.
authors.forename: C E
authors.initials: CE
authors.lastname: Connolley-Mendoza
authors.forename: T
authors.initials: T
authors.lastname: Bhatti
authors.forename: K
authors.initials: K
authors.lastname: Jericho
mesh_terms: D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000009:adverse effects*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D007275:Injections, Intravenous; D008198:Lymph Nodes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D010091:Oximes; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D012965:Sodium Chloride / Q000009:adverse effects
chemical_list: D000931:Antidotes; D010091:Oximes; D011726:Pyridinium Compounds; D012965:Sodium Chloride; C022870:asoxime chloride