Lymphoma of the mediastinum and neck: evaluation with Ga-67 imaging and CT correlation.
The role of gallium-67 in the differentiation between active disease and fibrotic changes in patients with childhood lymphoma involving the mediastinum and neck was evaluated prospectively. Ga-67 imaging and computed tomography (CT) were correlated with clinical findings at the time of initial presentation and follow-up in 19 patients. Both modalities enabled detection of active disease on all occasions, but CT results were false-positive for residual disease in 10 patients (53%), whereas Ga-67 imaging results were false-positive in only one patient (5%). Neither modality, however, proved accurate in patients with rebound thymic hyperplasia. Ga-67 imaging is a useful tool for assessing response to therapy in children with lymphoma of the mediastinum and neck.
Drossman
S R
SR
Department of Radiology, Schneider Children's Hospital, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Schiff
R G
RG
Kronfeld
G D
GD
McNamara
J
J
Leonidas
J C
JC
D000293:Adolescent; D000328:Adult; D002648:Child; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
D002951:Citrates; D005710:Gallium Radioisotopes; D019343:Citric Acid