Effect of anticalmodulin and antitubulin on LDL-receptor synthesis in aortic smooth muscle cells cultured in vitro.
Effect of trifluoperazine and colchicine on LDL-receptor synthesis in smooth muscle cells exposed to hypercholesterolemic medium in vitro have been studied. While trifluoperazine at 25 microM concentration caused stimulation of LDL-receptor synthesis, colchicine acted as a dose-dependent inhibitor of LDL-receptor synthesis. Thus calmodulin down regulates LDL-receptor synthesis independent of microtubular involvement.
Mehta
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U
Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Kaul
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D
D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D011973:Receptors, LDL / Q000096:biosynthesis* / Q000187:drug effects; D014268:Trifluoperazine / Q000494:pharmacology; D050257:Tubulin Modulators
D002147:Calmodulin; D011973:Receptors, LDL; D050257:Tubulin Modulators; D014268:Trifluoperazine; D003078:Colchicine