Gastric emptying of nondigestible solids in dogs: a hydrodynamic correlation.
The influence of particle size, particle density, fluid viscosity, and fluid flow rate on the gastric emptying of nondigestible solids was investigated in five dogs with chronically placed fistulas. Six hundred and fifty particles of 13 different size and density combinations were administered simultaneously with 500 ml of either normal saline or low-, medium-, or high-viscosity polymer solutions. The canine stomach was found to discriminate between these solids on the basis of size and density at all levels of viscosity above saline. The observed patterns of emptying are consistent with the hypothesis that gastric emptying of nondigestible solids is governed in part by hydrodynamics and correlate well with the gastric-emptying coefficient (GEC), a dimensionless grouping of variables that takes the form GEC = (Dpy/Dp) [g(rho f - rho p)Dp2]/[eta (nu)] where [g(rho f - rho p)] is particle buoyancy consisting of fluid (rho f) and particle (rho p) densities and g, the gravitational constant; (Dp) is the particle diameter, (Dpy) the estimated pyloric diameter, eta the fluid viscosity, and (nu) the average linear velocity of fluid exiting the stomach.
Sirois
P J
PJ
Eli Lilly and Company, Indianapolis, Indiana 46285.
Amidon
G L
GL
Meyer
J H
JH
Doty
J
J
Dressman
J B
JB
D000818:Animals; D004285:Dogs; D004435:Eating; D005260:Female; D005746:Gastric Emptying; D065347:Hypromellose Derivatives; D008433:Mathematics; D008747:Methylcellulose / Q000031:analogs & derivatives; D008954:Models, Biological; D011108:Polymers; D014783:Viscosity
D011108:Polymers; D065347:Hypromellose Derivatives; D008747:Methylcellulose