Topical propylene glycol and hyperosmolality.
Topical propylene glycol is known to cause elevated serum osmolality in burns patients. Twelve adults with skin disease had quantities of propylene glycol applied to their skin to a maximum of 6.1 g/kg per 24 h for 5 days. Serum electrolyte, lactate and osmolality results remained unchanged during the study. These results suggest that topical propylene glycol may be used in adult dermatological practice without affecting serum osmolality.
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Skin and Cancer Foundation, Ashley Centre, Westmead, NSW, Australia.
D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000097:blood*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011409:Propylene Glycols; D019946:Propylene Glycol