title: Determination of haloperidol and hydroxy haloperidol in human plasma by high performance liquid chromatography.
abstract: A method has been developed for the separation and measurement of haloperidol and hydroxy haloperidol in human plasma through high performance liquid chromatography. The method uses chlorohaloperidol as an internal standard and provides a limit of detection of about 0.7 nmol/l for haloperidol and 0.67 nmol/l for hydroxy haloperidol. HPLC and RIA radioimmunoassay methods are compared.
authors.affiliation: Laboratoire de Toxicologie, Faculté de Pharmacie, Laguesse, Lille.
authors.forename: J
authors.initials: J
authors.lastname: Pommery
authors.forename: O
authors.initials: O
authors.lastname: Foulon
authors.forename: G
authors.initials: G
authors.lastname: Morineau
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
authors.forename: J C
authors.initials: JC
authors.lastname: Levron
authors.forename: F
authors.initials: F
authors.lastname: Erb
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006220:Haloperidol / Q000031:analogs & derivatives / Q000097:blood*; D006801:Humans; D006900:Hydroxylation; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: C040693:1-(3-(4-chlorobenzoyl)propyl)-4-hydroxy-4-(4-chlorophenyl)piperidine; D006220:Haloperidol