title: Effect of low-frequency electric stimulation on in vivo release of cholecystokinin-like immunoreactivity in medial thalamus of conscious rat.
abstract: Release of cholecystokinin-like immunoreactivity (CCK-LI) in the medial thalamus of conscious rats was measured by brain dialysis and enzyme immunoassay. Analgesia caused by low-frequency electric stimulation of the tibial muscle, the tsusanli acupuncture point, was judged by change of pain threshold due to the stimulation. Medical thalamic CCK-LI released was increased by peripheral electric stimulations of both the acupuncture point and the non-acupuncture point. Results suggest that CCK acts as a neurotransmitter in the medial thalamus, a part of the analgesia inhibitory system.
authors.affiliation: Department of Life Chemistry, Tokyo Institute of Technology, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Aiuchi
authors.forename: K
authors.initials: K
authors.lastname: Nakaya
authors.forename: H
authors.initials: H
authors.lastname: Arakawa
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: A
authors.initials: A
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: C
authors.initials: C
authors.lastname: Takeshige
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D015667:Acupuncture Analgesia; D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D003956:Dialysis; D015671:Electroacupuncture; D007124:Immunoenzyme Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000378:metabolism*
chemical_list: D002766:Cholecystokinin