Iron, infection, and the role of bicarbonate.
Ferric iron will not saturate transferrin in Tris buffer, and its use in experimental infections has been criticized. However, in the presence of bicarbonate, as in plasma, saturation occurs rapidly. This is comparable to natural iron overload, and infections.
Bullen
J J
JJ
University of Miami School of Medicine, Department of Surgery, FL 33101.
Ward
C G
CG
Rogers
H J
HJ
D001424:Bacterial Infections / Q000378:metabolism*; D001639:Bicarbonates / Q000097:blood*; D005290:Ferric Compounds / Q000097:blood / Q000378:metabolism*; D006801:Humans; D000644:Quaternary Ammonium Compounds / Q000097:blood / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D001639:Bicarbonates; D005290:Ferric Compounds; D000644:Quaternary Ammonium Compounds; D014168:Transferrin; C013531:ferric ammonium citrate