[The modification of ciliary motility by salbutamol: a comparative study on subjects: oral vs inhalation administration].
15 healthy adults received for 3 days twice daily 8 mg salbutamol orally. Ciliary beat frequency was measured before, on the day of drug administration, 1 and 3 days after the beginning of the treatment, by means of nasal brush biopsy. In the same subjects ciliary beat frequency was determined before and 10 minutes following to the inhalation of 2.5 mg salbutamol with 2 ml of 0.9% saline. Findings suggest that by orally administered salbutamol a positive effect on ciliary beat frequency is yielded. The increase of frequency is more distinct in patients suffering from bronchial hyperreactivity. There was no statistically significant effect after inhalative administration of the drug.
Ahrens
P
P
Zentrum der Kinderheilkunde der Johann Wolfgang Goethe-Universität, Frankfurt/Main.
Zielen
S
S
Pawlik
D
D
Schulze
J
J
Hofmann
D
D
D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009068:Movement
D000420:Albuterol
Die Beeinflussung der Zilienmotilität durch Salbutamol: Eine vergleichende Untersuchung an Probanden: orale vs inhalative Applikation.