Influences of estrogen and/or progesterone on some dopamine related behavior in rats.
1. The effects of ovariectomy and/or of female hormonal treatments on open-field behavior, apomorphine-induced stereotypies and haloperidol-induced catalepsy were studied in rats. 2. Rat's locomotion frequency was significantly decreased by 17 beta-estradiol and estradiol plus progesterone treatments; this open-field parameter was not affected by progesterone administration per se. 3. 17 beta-estradiol and progesterone treatments, alone or in combination decreased apomorphine-stereotyped behavior. 4. Haloperidol effects were higher in both 17 beta-estradiol and 17 beta-estradiol plus progesterone treated rats. 5. Progesterone treatment alone, decreased the duration of catalepsy induced by the minor (1.0 mg/kg) neuroleptic dose. 6. These results were discussed in the light of a possible interference of estrogen and/or progesterone on dopaminergic transmission at the level of the nigroestratial pathway.
Palermo-Neto
J
J
Applied Pharmacology and Toxicology Laboratory School of Veterinary Medicine, University of São Paulo, Brazil.
Dorce
V A
VA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001592:Benzyl Alcohols / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D001592:Benzyl Alcohols; D004967:Estrogens; D011374:Progesterone; D006220:Haloperidol; D004298:Dopamine