title: Transformation of refractory anemia with excess of blasts into acute myelogenous leukemia with Ph-negative chronic myelogenous leukemia-like characteristics.
abstract: We report a 56 year old patient with acute myelogenous leukemia (FAB classification: M2), in whom the number of mature myeloid cells similar to those seen in Ph-negative chronic myelogenous leukemia increased markedly 2 months after the diagnosis of refractory anemia with excess of blasts (RAEB). This is a rare case of leukemic evolution as a terminal event of RAEB.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamauchi
authors.forename: S
authors.initials: S
authors.lastname: Arimori
authors.forename: T
authors.initials: T
authors.lastname: Nagao
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications*; D002871:Chromosome Banding; D002882:Chromosomes, Human, Pair 13; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic