title: Quantitative echocardiographic analysis of global and regional left ventricular function: a problem revisited.
abstract: We recorded two-dimensional echocardiograms simultaneously with the respiration measurements of 20 normal subjects and 20 patients with anterior myocardial infarction. The apical long-axis and four-chamber views were quantitatively analyzed. Measurement variability of global ejection fraction and regional ejection fraction of 100 regions was calculated during inspiration and at end-expiration for two observers. To minimize variability, the endocardial contour was redefined and traced with an improved computer-assisted tracing system. Variability (absolute mean difference) between two beats at end-expiration was significantly less than during inspiration (p less than 0.05): for ejection fraction the variability at end-expiration was 3.4% and the variability during inspiration was 6.4% (mean, 54%; SD, 7%); for regional ejection fraction the variability at end-expiration was 11.8% and the variability during inspiration was 21.5% (mean, 56%; SD, 15%). Intraobserver and interobserver variability values of one beat at end-expiration for ejection fraction were 3.1% and 3.8%, respectively, and 9.5% and 12.8%, respectively, for regional ejection fraction. Variability in patients with myocardial infarction was comparable. This method of recording respiration and analyzing left ventricular function at end-expiration, with a new contour definition and tracing system, provides a measurement variability that is considerably less than that reported in previous echocardiographic studies and that is comparable to angiographic methods.
authors.affiliation: Department of Clinical Echocardiography, Thoraxcenter, Erasmus University, The Netherlands.
authors.forename: P E
authors.initials: PE
authors.lastname: Assmann
authors.forename: C J
authors.initials: CJ
authors.lastname: Slager
authors.forename: S G
authors.initials: SG
authors.lastname: van der Borden
authors.forename: S T
authors.initials: ST
authors.lastname: Dreysse
authors.forename: J G
authors.initials: JG
authors.lastname: Tijssen
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D015588:Observer Variation; D012119:Respiration / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*