Involvement of sex hormone in body weight gain by selective D2 receptor antagonist sulpiride.
The effect of estrogen supplement on selective D2 receptor antagonist sulpiride induced weight gain was examined in ovariectomized (ovx.) rats. Sulpiride injection (10 mg/kg, s.c.) showed a significant increase of body weight and food consumption only in female rats. Bilateral ovariectomy completely abolished the weight gain and hyperphagia by sulpiride. Subcutaneous injection of estradiol benzoate (E2:5 micrograms/day, s.c.) for 14 days restored the effects of sulpiride on weight gain in ovx, rats and sulpiride injection with E2 supplement significantly increased the efficiency of food utilization. The present study suggested that estrogen should be involved in the induction of overweight and hyperphagia by sulpiride.
Shimizu
H
H
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Shimomura
Y
Y
Uehara
Y
Y
Kobayashi
I
I
Kobayashi
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004967:Estrogens / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D008297:Male; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013469:Sulpiride / Q000494:pharmacology*
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D013469:Sulpiride