title: Reversal of angiotensin converting enzyme (ACE) inhibitor induced vasodilatation by vasopressin in hindquarters of rat.
abstract: The effect of exogenously administered vasopressin was observed on captopril induced vasodilatation in hindquarters of anaesthetised rats. Drops of perfusate were counted for 6 min and mean of the outflow was expressed as drops per min (dpm). In the control group (n = 6) the rate of flow was 9.5 +/- 1.04 dpm which increased to 12.33 +/- 1.36 dpm following captopril (200 micrograms/ml) infusion. In test group (n = 6) pretreated with vasopressin (4 I.U./kg 1 hr before) the rate of flow was 9.16 +/- 0.98 dpm which was reduced to 5.5 +/- 1.04 dpm following infusion with captopril. It is concluded that vasopressin reverses the vasodilatory effect of captopril.
authors.affiliation: Department of Pharmacology, Christian Medical College, Vellore, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Tyagi
authors.forename: P M
authors.initials: PM
authors.lastname: Stephen
mesh_terms: D000818:Animals; D002216:Captopril / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation / Q000187:drug effects*; D014667:Vasopressins / Q000494:pharmacology*
chemical_list: D014667:Vasopressins; D002216:Captopril