title: Ciprofloxacin therapy of urinary tract infections in paraplegic and tetraplegic patients: a bacteriological assessment.
abstract: The efficacy of a 250 mg dose of oral ciprofloxacin twice daily for five days was studied in the treatment of urinary tract infection in paraplegic and tetraplegic patients. Thirty-eight patients completed the study. By day 3 of therapy the infecting organisms had been eradicated from the urine in 97.2% of the patients. Follow-up, post-therapy samples on day 14 showed 66.7% positive culture results and by day 35, 92.0% were positive. The ciprofloxacin therapy proved efficacious in 97.2% of the patients; however, the factors that predisposed this group of patients to urinary tract infections still persisted and reinfection or superinfection occurred in 92.0%. There was one case of persistent infection caused by Enterococcus faecalis.
authors.affiliation: Department of Microbiology, National Hospital for Nervous Diseases, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Stannard
authors.forename: S J
authors.initials: SJ
authors.lastname: Sharples
authors.forename: P M
authors.initials: PM
authors.lastname: Norman
authors.forename: G S
authors.initials: GS
authors.lastname: Tillotson
mesh_terms: D000284:Administration, Oral; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000652:urine; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D010264:Paraplegia / Q000150:complications*; D011782:Quadriplegia / Q000150:complications*; D012074:Remission Induction; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002939:Ciprofloxacin