Effect of fluid intake on renal function during exercise in the cold.
The effect of an imposed drinking discipline versus ad libitum drinking was studied on 21 healthy, well-trained volunteers, during a continuous 4.5-h march at an altitude of 1,700 m and an ambient temperature of 0 degree C, SD 1. Group I (n = 13) was instructed to drink 250 ml of warmed, artificially sweetened fluid every 30 min, whereas group II (n = 8) drank plain water ad libitum. The median fluid intake in group I was significantly higher than in group II (P less than 0.0002). Serum urea and osmolality decreased during the march in group I (P less than 0.05; P less than 0.002, respectively) with no significant change in group II. In both groups, a similar increase in haemoglobin concentration concomitant with a reduction in calculated blood and plasma volume was observed after exercise and did not correlate with the state of hydration. Total urine volume, creatinine clearance, urea clearance and potassium excretion were significantly higher and urinary osmolality was lower in group I than in group II (P less than 0.05). These results reflect a state of extreme "voluntary dehydration" in the control group when no fluid intake was obligatory. Thus, during exercise in the cold, under conditions similar to those in this study, a fluid intake of 150 ml.h-1 should be maintained in order to keep a urinary flow of about 1 ml.kg-1.h-1 and to achieve a good state of hydration.
Dann
E J
EJ
Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, Israel.
Gillis
S
S
Burstein
R
R
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003080:Cold Temperature; D004326:Drinking; D004906:Erythrocyte Count; D015444:Exercise / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D006454:Hemoglobins; D014508:Urea; D012964:Sodium; D011188:Potassium