title: [Ultrastructural changes in the cells of the vasopressin-sensitive epithelia during the stimulation of water transport].
abstract: The author's own and literary data are reviewed on the ultrastructural changes in cells of tight epithelia at the stimulation of osmotic water flows by vasopressin. The results of the relevant morphofunctional studies proved the idea of the transcellular water transport, being the following: 1) the absence of structural changes of tight junction under big water flows; 2) the appearance of domains with high water permeability (aggregates of IMP) in the apical membranes of cells transporting water; 3) changes in the vacuolar system of cells resulting in the appearance of gigantic vacuoles involved in transcellular water transport and in osmoregulation; 4) the redistribution of microfilaments and the enlargement of microtubules during the water transport. Hypotheses are discussed accounting for the origin of water channels from intracellular sources (aggrephores or/and granules); in addition, structural peculiarities and genesis of gigantic vacuoles are considered.
authors.forename: E S
authors.initials: ES
authors.lastname: Snigirevskaia
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D007685:Kidney Tubules, Collecting / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D009995:Osmosis / Q000187:drug effects; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D014667:Vasopressins / Q000502:physiology*; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water; D014667:Vasopressins
vernacular_title: Izmenenie ul'trastruktury kletok vazopressin-chuvstvitel'nykh épiteliev pri stimuliatsii transporta vody.