title: Low-dose methylphenidate in the very old.
abstract: Two patients, aged 104 and 91 years, who presented with medical problems and depression were successfully treated with 1.25 to 5 mg of methylphenidate without evidence of tolerance or toxicity. Benefits were sustained for more than 8 months on smaller amounts of this central nervous system stimulant than has been previously reported.
authors.affiliation: Harvard Medical School, Boston, MA.
authors.forename: B
authors.initials: B
authors.lastname: Gurian
authors.forename: E
authors.initials: E
authors.lastname: Rosowsky
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D008774:Methylphenidate