Sodium-22 influx into erythrocytes from diabetic hypertensive patients on maintenance hemodialysis.
We have studied the percentage of 22Na+ uptake in cell suspensions; 0.4 to 2.0 x 10(9) erythrocytes/mL from diabetic uremic patients with secondary hypertension and from normal subjects. Suspensions from diabetic uremic patients with secondary hypertension 0.42 +/- 0.06 to 2.05 +/- 0.28; normal subjects showed a percentage uptake of 22Na+ of 0.27 +/- 0.05 to 1.28 +/- 0.22. The uptake of 22Na+ in 2.0 x 10(9) cells/mL was 60% more (P less than .05) in diabetic uremic patients than in the controls. These studies indicate that 22Na+ influx determinations may be used to distinguish secondary hypertensive patients from normal subjects.
Gambhir
K K
KK
Department of Medicine, Howard University Hospital, Washington, DC 20060.
Mathews
J
J
Parui
R
R
Cruz
I A
IA
Hosten
A O
AO
Dillard
M G
MG
D000328:Adult; D000368:Aged; D001693:Biological Transport, Active; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012964:Sodium / Q000378:metabolism*; D012979:Sodium Radioisotopes; D014511:Uremia / Q000209:etiology / Q000378:metabolism
D012979:Sodium Radioisotopes; D012964:Sodium