title: Hypoglycemia, hormones and cytokines in fatal meningococcal septicemia.
abstract: A unique case report with sequential measurements of the plasma concentrations of glucoregulatory hormones, interleukin-6 and tumor necrosis factor during development of hypoglycemia in fatal meningococcemia is presented. Hormonal explanations for hypoglycemia like hyperinsulinemia or defective hypoglycemic counter-regulation were excluded. Plasma concentrations of interleukin-6 and tumor necrosis factor were skyhigh. The putative relation between cytokines and hypoglycemia in sepsis is discussed.
authors.affiliation: Department of Intensive Care, University of Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: M H
authors.initials: MH
authors.lastname: Godfried
authors.forename: C
authors.initials: C
authors.lastname: Wortel
authors.forename: H P
authors.initials: HP
authors.lastname: Sauerwein
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D006728:Hormones / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008589:Meningococcal Infections / Q000097:blood* / Q000150:complications; D018805:Sepsis / Q000097:blood* / Q000150:complications; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D006728:Hormones; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha