Evaluation of detergent-induced irritant skin reactions by visual scoring and transepidermal water loss measurement.
Transepidermal water loss measurements proved to be more accurate and sensitive than visual scoring in discriminating the irritating action of detergents on the skin. Further, the baseline transepidermal water loss might be a reliable indicator of an individual's susceptibility to weak irritants.
Tupker
R A
RA
Occupational Dermatology Unit, State University Hospital, Groningen, The Netherlands.
Pinnagoda
J
J
Coenraads
P J
PJ
Nater
J P
JP
D003902:Detergents / Q000494:pharmacology*; D004890:Erythema / Q000139:chemically induced; D006801:Humans; D007509:Irritants / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012879:Skin Physiological Phenomena; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors; D014870:Water Loss, Insensible / Q000187:drug effects*
D003902:Detergents; D007509:Irritants; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; C028913:dodecyl sulfate