Carbamazepine-induced bradycardia-tachycardia syndrome with pharmacological analysis and concurrent ECG monitoring.
The authors present a patient with carbamazepine-induced bradycardia-tachycardia syndrome, a rare type of drug-induced sinus node dysfunction. In this case, they established a clear-cut relationship between plasma carbamazepine concentration and the frequency of sinus arrests, following episodes of supraventricular tachycardia. As the pharmacological analysis of drug-induced sinus node dysfunction by concurrent ECG monitoring is very limited, the findings give an insight into the mechanism of this disorder.
Takayanagi
K
K
Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan.
Yamaguchi
H
H
Hayashi
T
T
Morooka
S
S
Takabatake
Y
Y
D000368:Aged; D001919:Bradycardia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D013577:Syndrome; D013617:Tachycardia, Supraventricular / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis
D002220:Carbamazepine