[Cross circulation (CC) as an assist method for canine orthotopic cardiac transplantation--estimation of usefulness judging from intra- and postoperative hematological and biochemical examinations].
We employed cross circulation (CC) as an assist method for canine orthotopic cardiac transplantation in 8 dogs to obtain long term survivals. Hematological and biochemical examinations were performed intra- and postoperatively, to estimate usefulness of CC. The support dog weighted about 3 times as much as the recipient dog. Using different anesthesia, the systolic pressure of the support dog and the pressure gradient between the support and recipient were kept above 150 mmHg and 50 mmHg, respectively. Cyclosporin and prednisolone were administered for immunosuppressive therapy. All could be extubated on the 1st to 3rd postoperative day, and 6 survived more than 2 weeks. During the operation under CC, changes of LDH and lactic acid were much less, no free hemoglobin was detected, and total protein and hematocrit remained well compared with operation under heart-lung machines. CRK, CPKMB, GOT and GPT increased shortly after operation, but returned to the preoperative values within 2 weeks. In CC, owing to avoidance from mechanical destruction of red blood cells, coagulation disorders and hemodilution, hemolysis and hemorrhage could be decreased, and oncotic pressure remained well, and no severe damage occurred in the recipient organs. Thus, CC is useful as an assist method for canine orthotopic cardiac transplantation.
Ito
M
M
Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Kanki
Y
Y
Murayama
Y
Y
Yaku
H
H
Kawachi
H
H
Aikawa
I
I
Oga
K
K
Oka
T
T
D000818:Animals; D001774:Blood Chemical Analysis; D003427:Cross Circulation; D003524:Cyclosporins / Q000008:administration & dosage; D004285:Dogs; D006085:Graft Survival; D016027:Heart Transplantation / Q000401:mortality*; D006355:Heart-Lung Machine; D006400:Hematocrit; D006439:Hemodynamics; D010100:Oxygen / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage
D003524:Cyclosporins; D011239:Prednisolone; D010100:Oxygen