[Antagonism of Zn2+ on nootropic action of piracetam in mice].
In mouse step-down test, the memory impairments of acquisition, consolidation and recognition were induced by anisodine, chloramphenical and ethanol, respectively. Piracetam 100 mg/(kg.d) ip for 5 d improved the anisodine-induced impairment of learning. ZnSO4 5 mg/(kg.d) po for 5 d did not improve the 3 impairments. Memory impairments were enhanced by a combined administration of ZnSO4 and piracetam in these 3 models. These results were confirmed by Y-maze method in normal mice.
Zhu
T J
TJ
Department of Pharmacology, Wenzhou Medical College, China.
Chen
X Y
XY
Pan
J C
JC
Zhang
S S
SS
D000818:Animals; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010889:Piracetam / Q000494:pharmacology*; D013431:Sulfates / Q000037:antagonists & inhibitors*; D015032:Zinc / Q000037:antagonists & inhibitors*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc; D010889:Piracetam