title: The role of radiation therapy following resection of single brain metastasis from melanoma.
abstract: From 1972 to 1987, 35 patients underwent resection of a single brain metastasis from melanoma; 19 received postoperative radiation therapy (RT) (group A), and 16 did not (group B). Group A had a longer interval to CNS relapse compared with group B, but survival was similar. However, 4/17 (24%) from group A and 11/13 (85%) from group B died of neurologic causes. We conclude that patients with single brain metastasis from melanoma have improved control of CNS disease when postoperative RT is administered, and survival depends upon control of systemic disease.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: N A
authors.initials: NA
authors.lastname: Hagen
authors.forename: C
authors.initials: C
authors.lastname: Cirrincione
authors.forename: H T
authors.initials: HT
authors.lastname: Thaler
authors.forename: L M
authors.initials: LM
authors.lastname: DeAngelis
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D012640:Seizures / Q000188:drug therapy; D012878:Skin Neoplasms
chemical_list: D000927:Anticonvulsants