Stressor induced variations of intracranial self-stimulation from the mesocortex in several strains of mice.
Intracranial self-stimulation (ICSS) from the mesocortex was assessed in BALB/cByJ, C57BL/6J and DBA/2J mice immediately, 24 h and again 168 h following stressor application. Stressor exposure failed to influence ICSS performance in C57BL/6J mice, while self-stimulation performance was reduced among BALB/cByJ mice only in the immediate post-stressor interval. In contrast, DBA/2J mice exhibited reduced rates of responding for brain stimulation at each of the post-stressor intervals. The potential contribution of DA alterations to the strain-dependent variations of ICSS performance induced by uncontrollable footshock are discussed.
Zacharko
R M
RM
Carleton University, Ottawa, Ontario, Canada.
Gilmore
W
W
MacNeil
G
G
Kasian
M
M
Anisman
H
H
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012653:Self Stimulation / Q000502:physiology*; D013045:Species Specificity; D013312:Stress, Physiological / Q000503:physiopathology*