[The effects of the acute administration of vinburnine on blood rheology, oxygen transport and regional circulation under normal conditions and in hypoxemia. In vivo research].
Vinburnine has been shown to be effective in avoiding chronic ischaemic tissue injury. Many studies have demonstrated the antihypoxic and oxygenation properties of this drug. In our study we have evaluated in two groups of patients the effects on blood rheology, oxygen transport, regional circulation and ergospirometric data of 40 mg vinburnine infused in a systemic vein. We have selected in the first group 10 patients with low hemoglobin oxygen affinity (p50 28.6 +/- 1.37 mmHg), in the second one 7 patients with normal values (p50 26.6 +/- 0.84 mmHg). In the two groups of the study we evaluated nutritional blood flow by a plethysmographic method, blood gas analysis [correction of hemogasanalitic] parameters in arterial and venous blood, haemoglobin oxygen affinity expressed as p50 and erythrocytic 2,3-DPG, hemorheologic and ergospirometric parameters. Data were evaluated in basal conditions and at the end of the infusion. The improvement of rheological properties, hemodynamic and metabolic data in the two groups of the study seems to confirm the oxyphoretic properties of this drug.
Domini
L
L
Istituto di Patologia speciale medica e Metodologia clinica, Università, Siena.
Acciavatti
A
A
Galigani
C
C
Saletti
M
M
De Franco
V
V
Pecchi
S
S
Auteri
A
A
Di Perri
T
T
D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D007262:Infusions, Intravenous; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*
D006454:Hemoglobins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C016422:eburnamonine; D010100:Oxygen
Effetti della somministrazione acuta di vinburnina sulla reologia ematica, trasporto dell'ossigeno e sulla circolazione distrettuale in condizioni normali e di ipossiemia. Richerche in vivo.