title: Blood-brain barrier permeability: regional alterations after acute and chronic administration of ethinyl estradiol.
abstract: In this study we measured the effect of acute and chronic estrogen treatment on cerebrovascular permeability to sucrose and inulin. Animals were subcutaneously injected once with 0.1 micrograms/rat of ethinyl estradiol or injected daily with the same drug dose for 3 weeks. Control rats received the same amount of arachis oil vehicle. Three weeks treatment but not the single injection of ethinyl estradiol produced significant increases in the cerebrovascular permeability-surface area product for sucrose and inulin in almost all brain regions.
authors.affiliation: Department of Physiology, Istanbul Faculty of Medicine, Turkey.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Ziylan
authors.forename: J M
authors.initials: JM
authors.lastname: Lefauconnier
authors.forename: G
authors.initials: G
authors.lastname: Bernard
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002250:Carbon Radioisotopes; D004334:Drug Administration Schedule; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D014316:Tritium; D004997:Ethinyl Estradiol