title: [Radical radiation therapy of carcinoma of the rhinopharynx: analysis of 80 cases].
abstract: From 1976 to 1987, 98 patients affected with nasopharyngeal carcinoma were observed at the Oncology Center, Trento, Italy. Eighty of them were treated with radical radiation therapy (average total dose: 6432 Gy, range: 5500-7400 Gy) on primary tumor and positive neck nodes. The clinically negative neck received 5000 Gy. Each dose ranged from 180 to 250 Gy. Fifty-nine patients were treated with the split-course technique with an interval of about 15 days after receiving 4000 cGy. The patients were 60 males and 20 females, their age ranging 17-81 years (mean: 57 years). Histology diagnosed squamous cell carcinoma in 15 cases and undifferentiated carcinoma in 65 cases. All patients were staged according to TNM (UICC, 1978) criteria. Ten patients were stage I/II. Complete local control was obtained in 81.3% of cases. Actuarial global survival at 10 years was 52%, actuarial relapse-free survival was 49%. Mean follow-up is 33 months (range: 4-122 months). Squamous cell carcinoma at histology and advanced nodal involvement (N2-N3) were negative prognostic factors. Six patients had a relapse in the nasopharynx and 5 in the neck; the incidence of distant failures was 20%. The most frequent mid-/long-term side-effect was xerostomia.
authors.affiliation: Centro Oncologico-Radioterapia, Ospedale S. Chiara, Trento.
authors.forename: M
authors.initials: M
authors.lastname: Amichetti
authors.forename: C
authors.initials: C
authors.lastname: Graiff
authors.forename: A
authors.initials: A
authors.lastname: Bolner
authors.forename: L
authors.initials: L
authors.lastname: Busana
authors.forename: G
authors.initials: G
authors.lastname: Fellin
authors.forename: G
authors.initials: G
authors.lastname: Pani
authors.forename: S
authors.initials: S
authors.lastname: Maluta
authors.forename: E
authors.initials: E
authors.lastname: Nassivera
authors.forename: A
authors.initials: A
authors.lastname: Valentini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality; D009364:Neoplasm Recurrence, Local; D011832:Radiation Injuries; D011859:Radiography; D012189:Retrospective Studies; D015996:Survival Rate
vernacular_title: Il trattamento radiante radicale del carcinoma della rinofaringe: analisi su 80 casi.