[Effects of dalargin on the processes of cell division in the gastric epithelium during stress].
Influence of dalargine on cell division in stomach epithelium of male rats, stressed by 4-hour immobilization was studied using autoradiographic 3H-thymidine test. Norepinephrine and diene conjugates content in stomach tissue were also determined in these animals spectrofluorometrically. Dalargine (10 micrograms/kg) gas injected to experimental group 40 min before stressing. Dalargine prevented stress-induced DNA-synthesis disturbances and stabilized proliferating cells pool just after the stress. It also decreased proliferation processes depression in 12 and 24 hours after stress and accelerated compensatory DNA-synthesis.
Timoshin
S S
SS
Shvets
S I
SI
Murzina
N B
NB
Berezina
G P
GP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism*; D007103:Immobilization; D008297:Male; D051381:Rats; D013270:Stomach / Q000473:pathology; D013312:Stress, Physiological / Q000378:metabolism* / Q000473:pathology; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D013565:Sympatholytics; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na protsessy razmnozheniia kletok v épitelii zheludka pri stresse.