Pancytopenia in systemic lupus erythematosus related to azathioprine.
A patient with systemic lupus erythematosus (SLE) developed pancytopenia when azathioprine (first 2.0 mg kg-1 day-1, then 2.5 mg kg-1 day-1) was added to prednisone for active SLE. This unusual toxic effect of azathioprine occurred during the reduction of corticosteroid dosage. After discontinuation of azathioprine, clinical and haematological recovery occurred.
Nossent
J C
JC
Department of Rheumatology, Dr. Daniel den Hoed Clinic, Rotterdam, The Netherlands.
Swaak
A J
AJ
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D010198:Pancytopenia / Q000139:chemically induced*
D001379:Azathioprine