[Autologous liposomes].
A possibility to increase liposomal tropism to different organs by obtaining them from target lipid cells is considered. The interaction of liposomes of varying phospholipid and ganglioside composition with hepatic cells of rats was studied in vitro. It was found that this interaction was governed both by the phospholipid and ganglioside composition of the vesicles. Liposomes formed of phospholipids and gangliosides of target cells were captured better by the cells. Liposomes formed by summary hepatic phospholipids and gangliosides were shown to be eliminated more rapidly from the flow and to accumulate in the liver of the rats. This suggests that liposomal affinity for specific organs may be increased by changing the content and proportion of lipids in the liposomes to attain the maximal similarity to the composition of the target cell membranes.
Saatov
T S
TS
Isaev
E I
EI
Burkhanov
S A
SA
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D005732:Gangliosides / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000166:cytology* / Q000648:ultrastructure; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010743:Phospholipids / Q000008:administration & dosage*; D051381:Rats; D011955:Receptors, Drug / Q000502:physiology*
D005732:Gangliosides; D008081:Liposomes; D004364:Pharmaceutical Preparations; D010743:Phospholipids; D011955:Receptors, Drug
Autologichnye liposomy.