title: Complete response to combination therapy with an LHRH agonist and flutamide in metastatic male breast cancer: a case report.
abstract: Twelve months after modified radical mastectomy with axillary dissection (4 out of 13 nodes found positive) in a 66-year old man, bone scintigraphy showed multiple bone metastases. Treatment was started with the combined administration of an LHRH agonist and the pure antiandrogen Flutamide. Six and a half months later, bone scintigraphy was normal while serum testosterone was reduced to 10% of control and the serum concentration of the adrenal steroids was decreased by 23 to 45%. Following relapse of the disease at 12 months, more complete blockade of adrenal steroid secretion was achieved with aminoglutethimide and hydrocortisone. Stability of the disease was then observed up to the last evaluation performed in January 1990 (5 years of stable disease). Since the adrenal steroids are converted into active androgens and estrogens in peripheral tissues, including the breast, the combined therapy has the advantage of reducing the source of potentially active estrogens and androgens while blocking the action of androgens in target tissues. No side-effects other than those due to hypoandrogenicity, namely hot flushes and loss of libido and potency were observed. This well-tolerated treatment achieves complete medical castration, partial medical adrenalectomy, and neutralization of peripheral androgen action.
authors.affiliation: MRC Group in Molecular Endocrinology, CHUL Research Centre, Quebec.
authors.forename: F
authors.initials: F
authors.lastname: Labrie
authors.forename: A
authors.initials: A
authors.lastname: Dupont
authors.forename: A
authors.initials: A
authors.lastname: Bélanger
authors.forename: Y
authors.initials: Y
authors.lastname: Lacourcière
authors.forename: L
authors.initials: L
authors.lastname: Béland
authors.forename: L
authors.initials: L
authors.lastname: Cusan
authors.forename: R
authors.initials: R
authors.lastname: Lachance
mesh_terms: D000368:Aged; D000616:Aminoglutethimide / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005485:Flutamide / Q000008:administration & dosage* / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male
chemical_list: C062225:LHRH, Trp(6)-des-GlyNH2(10)-; D000616:Aminoglutethimide; D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide; D006854:Hydrocortisone