Correlation of regional cerebral blood flow with performance on neuropsychological tests in schizophrenic patients.
Regional cerebral blood flow (rCBF) was determined by the 133Xe inhalation technique (Headtome II: ring detection SPECT) in 53 DSM-III schizophrenic patients. The rCBF values were corrected by using end-tidal carbon dioxide concentration values (PECO2). After rCBF measurement, neuropsychological tests--Word Fluency Test, Maze Test and Wisconsin Card Sorting Test--were performed. There were significant correlations between frontal rCBF and scores on each neuropsychological test. In particular, a moderate correlations between the frontal rCBF and the performance on the Wisconsin Card Sorting Test was noted. It seems likely that decrease of rCBF in prefrontal regions at rest reflects a disturbance of frontal lobe function in schizophrenic patients.
Sagawa
K
K
Department of Neuropsychiatry, Yamagata University School of Medicine, Japan.
Kawakatsu
S
S
Shibuya
I
I
Oiji
A
A
Morinobu
S
S
Komatani
A
A
Yazaki
M
M
Totsuka
S
S
D000328:Adult; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014055:Tomography, Emission-Computed; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes