title: Preservation of short-term energy balance in clinically stable patients with AIDS.
abstract: Malnutrition in patients with acquired immune deficiency syndrome (AIDS) is common and multifactorial. The possible causes of malnutrition were evaluated by performing studies of energy balance in five clinically stable outpatients with AIDS, six seronegative homosexual control subjects, and five seronegative heterosexual control subjects. The AIDS group was significantly depleted of body cell mass compared with the control subjects but the values did not change significantly over 6 wk. Food intake was normal in the AIDS group whereas intestinal absorptions of the pentose sugar xylose and of the triglyceride triolein were both significantly diminished. The AIDS patients were hypometabolic as compared with the control subjects and with predictions of metabolic rate based on the Harris-Benedict equation. We conclude that short-term energy balance can be maintained in clinically stable patients with AIDS. Hypometabolism is an appropriate metabolic response to the combination of body-cell-mass depletion and nutrient malabsorption.
authors.affiliation: Department of Medicine, St Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York.
authors.forename: D P
authors.initials: DP
authors.lastname: Kotler
authors.forename: A R
authors.initials: AR
authors.lastname: Tierney
authors.forename: S K
authors.initials: SK
authors.lastname: Brenner
authors.forename: S
authors.initials: S
authors.lastname: Couture
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: R N
authors.initials: RN
authors.lastname: Pierson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000378:metabolism*; D000328:Adult; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D004435:Eating; D004734:Energy Metabolism; D006801:Humans; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000150:complications / Q000378:metabolism; D008297:Male; D009748:Nutrition Disorders / Q000209:etiology / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D011446:Prospective Studies; D014304:Triolein / Q000378:metabolism; D014994:Xylose / Q000378:metabolism
chemical_list: D014304:Triolein; D014994:Xylose; D011188:Potassium