[Age-related features of cardiac contractility and its adrenergic regulation in catecholamine damage to the myocardium].
Studies on isolated rat hearts showed that in contrast to 8-month-old animals, in 26-month-old rats the contractile activity of the myocardium increases by the 3rd day after administration of toxic adrenalin doses (1 mg/kg i.m.). The maximum functional response of catecholamine injured hearts to stimulation of alpha- and beta-adrenoceptors reduced in both age groups, while the sensitivity of the myocardium to beta-adrenoceptor agonists in mature rats increased.
Lobanok
L M
LM
Kirienkov
A E
AE
Khotianova
O N
ON
D000375:Aging / Q000502:physiology*; D000818:Animals; D004837:Epinephrine / Q000633:toxicity*; D006321:Heart / Q000294:innervation; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*
D011941:Receptors, Adrenergic; D004837:Epinephrine
Vozrastnye osobennosti sokratimosti serdtsa i ee adrenergicheskoĭ reguliatsii pri katekholaminovykh povredzhdeniiakh miokarda.