title: Localization of auditory response sources using magnetoencephalography and magnetic resonance imaging.
abstract: Magnetoencephalography offers the possibility of localizing accurately and noninvasively the source of intracranial currents associated with normal and abnormal brain activity. The purpose of this study was to assess the validity and across-subject reliability of localization of cortical sources responding to ipsilateral and contralateral auditory stimulation. Magnetic evoked fields to both stimulation conditions were measured in eight consecutive normal subjects, and the cortical sources of these fields were estimated on the basis of these measurements. Subsequent projection of the source location coordinates onto magnetic resonance images showed that in all subjects the sources were accurately estimated to fall in the vicinity of the auditory cortex and that two separate sources may account for the response to ipsilateral and contralateral stimulation.
authors.affiliation: Division of Neurosurgery, University of Texas Medical Branch, Galveston 77550.
authors.forename: A C
authors.initials: AC
authors.lastname: Papanicolaou
authors.forename: S
authors.initials: S
authors.lastname: Baumann
authors.forename: R L
authors.initials: RL
authors.lastname: Rogers
authors.forename: C
authors.initials: C
authors.lastname: Saydjari
authors.forename: E G
authors.initials: EG
authors.lastname: Amparo
authors.forename: H M
authors.initials: HM
authors.lastname: Eisenberg
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001921:Brain / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results