[Effects of Shosaiko-to-go-keishikashakuyaku-to (TJ-960) on the valproic acid induced anomalies of rat fetuses].
Shosaiko-to-go-keishikashakuyaku-to (TJ-960) is an extract of nine herbal drugs (Paeoniae radix, Cinna momi cortex, Bupleuri radix, Zingiberis rhizoma, Glycyrrhizae radix, Ginseng radix, Scutellariae radix, Pinelliae tuber and Zizyphi fructus) that has a potent anticonvulsant action. The rat fetuses treated orally with TJ-960 during the organogenesis period (days 7-17 of gestation) revealed no anomalies (up to 3000 mg/kg/day). When TJ-960 was co-administered with sodium valproate (VPA, 400 mg/kg) during the organogenesis period, embryonic resorption, fetal body weight, ossification and skeletal variation or anomalies induced by VPA were markedly reduced. The maternal plasma and embryonic concentration of VPA with TJ-960, however, were not significantly different from VPA alone. These results suggest that TJ-960 has protective effects against the teratogenicity of VPA.
Minematsu
S
S
Research Institute for Pharmacology, Tsumura and Co., Ibaraki, Japan.
Taki
M
M
Watanabe
M
M
Takahashi
M
M
Wakui
Y
Y
Ishihara
K
K
Takeda
S
S
Fujii
Y
Y
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; C461320:shosaiko-to; D014635:Valproic Acid