[Synthesis and inhibition on beta-lactamase of 4-(3-amido-4-substituted phenyl-2-oxo-azetidinonyl-1)methyl-cyclohexane carboxylic acids and -benzoic acids].
Eleven title compounds have been synthesized from trans-4-amino-methyl-cyclohexylic acid and 4-aminomethyl-benzoic acid, and were identified via elemental analysis, IR, 1HMNR and MS. Their beta-lactamase inhibition activity was determined and contrasted with penicillanic acid S-dioxide. The results of the preliminary test show that all the products have beta-lactamase inhibition activity to some extent.
Yin
S F
SF
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Mao
W R
WR
D001384:Azetidines / Q000138:chemical synthesis* / Q000494:pharmacology; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
D001384:Azetidines; D001565:Benzoates; D003509:Cyclohexanecarboxylic Acids; D065093:beta-Lactamase Inhibitors; C067209:4-(3-amino-2-oxoazetidinonyl-1)methylbenzoic acid; C067208:4-(3-amino-2-oxoazetidinonyl-1)methylcyclohexanecarboxylic acid