title: [The therapeutic effect of parlodel in the polycystic ovary syndrome].
abstract: Parlodel (2.5-50 mg/day) has been given for 1 to 7 days to 33 patients with the polycystic ovary syndrome (POS). The ovulatory menstrual cycle returned in 10 (30%) patients and 4 of them conceived. Pretreatment cycle disturbance persisted in 6 (18%) patients. Parlodel reduced mid-follicular mean blood LH levels to values of normal women. Some decrease in blood testosterone levels occurred only in the second phase of the cycle. Estradiol test in 6 patients showed normal positive and negative feedbacks in the hypothalamic-pituitary-ovarian axis. Parlodel treatment reduced basal and estradiol stimulated pituitary gonadotropin secretion. It is suggested that parlodel may be used in ovulation induction in a proportion of POS patients.
authors.forename: E L
authors.initials: EL
authors.lastname: Soboleva
authors.forename: E K
authors.initials: EK
authors.lastname: Komarov
authors.forename: V V
authors.initials: VV
authors.lastname: Potin
authors.forename: F A
authors.initials: FA
authors.lastname: Svechnikova
mesh_terms: D000293:Adolescent; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use*; D004341:Drug Evaluation; D004958:Estradiol / Q000097:blood; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D008599:Menstruation Disturbances / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood
chemical_list: D006065:Gonadotropins, Pituitary; D001971:Bromocriptine; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol
vernacular_title: Lechebnyĭ éffekt parlodela pri sindrome polikistoznykh iaichnikov.