[The effect of a diet enriched with omega-3 polyunsaturated fatty acids on thrombocyte functional activity and on the blood lipid-apolipoprotein spectrum in newly occurring stenocardia].
The diet enriched with omega-3 polyunsaturated fatty acids (5 g/day for 4 weeks) was applied to the treatment of patients (n-22) with angina pectoris occurring for the first time. Meanwhile 6 patients received the control diet similar to the fish one as regards the protein, fat, carbohydrate, cholesterol and caloric ratio. The control group patients showed no alterations in blood lipids and apoproteins of in platelet function. The patients who received the fish diet manifested an appreciable decrease in the concentration of triglycerides (p less than 0.01), a slight reduction of cholesterol content. The level of high density cholesterol remained unchanged. There was a decrease in the concentration of thromboxane (p less than 0.05) and in the platelet count (p less than 0.05). In some patients, individual reactions of ADP-induced platelet aggregation were revealed: from the lowering (-60-10%) seen in the third of the examined up to the rise (+10+90%) in the other third. The decrease of apoprotein A1 established as safe for the protective cholesterol-transport properties of high-density lipoproteins was established.
Kalinkina
O M
OM
Perova
N V
NV
Zykova
V P
VP
Gratsianskiĭ
N A
NA
Mel'kina
O E
OE
Sokolova
M A
MA
Oganov
R G
RG
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy*; D001053:Apolipoproteins / Q000097:blood / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005396:Fish Products; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D005082:Physical Exertion
D001053:Apolipoproteins; D003692:Delayed-Action Preparations; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D008055:Lipids; D009566:Nitrates
Vliianie diety, obogashchennoĭ omega-3 polinenasyshchennymi zhirnymi kislotami, na funktsional'nuiu aktivnost' trombotsitov i lipidno-apolipoproteinovyĭ spektr krovi pri vpervye vozniksheĭ stenokardii.