Theophylline tablets coated with aqueous latexes containing dispersed pore formers.
Constant drug release was achieved from theophylline tablets coated with a multiporous membrane in an aqueous environment. The tablets were coated with an aqueous acrylic latex containing a dispersed pore-forming agent with pH-dependent solubility characteristics. The pore former, dibasic calcium phosphate, was insoluble in the latex but leached out rapidly in 0.1 M HCl. Theophylline was then released at a constant rate through the multiporous membrane. The drug release was a function of the level of the pore-forming agent and the membrane thickness, but independent of the pH of the dissolution medium and the degree of agitation.
Bodmeier
R
R
College of Pharmacy, University of Texas at Austin, TX 78712.
Paeratakul
O
O
D002626:Chemistry, Pharmaceutical; D004577:Electron Probe Microanalysis; D005079:Excipients; D007840:Latex; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013806:Theophylline / Q000008:administration & dosage*
D005079:Excipients; D007840:Latex; D013608:Tablets, Enteric-Coated; D013806:Theophylline