title: Synthesis of acetylenic spirobutenolide derivatives and evaluation of their growth inhibitory effect on cells in culture.
abstract: Acetylenic spirobutenolide amides and esters and their Mannich bases were synthesized to evaluate their growth inhibitory effect. The biological tests have used both normal and transformed cells and they have shown the selectivity of the prepared compounds. The ester derivatives presented the best selectivity comparable to that of daunorubicin.
authors.affiliation: Laboratoire de Chimie, Thérapeutique, Faculté de Pharmacie, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Bador
authors.forename: J
authors.initials: J
authors.lastname: Chantepie
authors.forename: J
authors.initials: J
authors.lastname: Paris
authors.forename: G
authors.initials: G
authors.lastname: Quash
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008352:Mannich Bases; D009363:Neoplasm Proteins; D013141:Spiro Compounds; D009955:Ornithine Decarboxylase