Effect of methionine on regional CDF-1 mouse brain monoamines.
The effect of methionine on cerebral content of dopamine, serotonin and major acidic metabolites was studied in distinct CDF-1 mouse brain regions. Methionine was administered 30 mg/kg for five trials over 24 h and mice were sacrificed 30 min post the terminal treatment. Methionine exerted differential effects on regional brain concentrations of 3,4-dihydroxyphenylacetic acid and serotonin. The results suggest methionine-mediated decreases of dopamine turnover in the hippocampus and medulla compared to increases of serotonin turnover in the cerebral cortex and midbrain regions. The results indicate a central action for methionine as related to endogenous neurotransmitters measured which may precede the abnormal O- or N-dimethylation ascribed to methionine and the insuing adverse effects postulated in schizophrenia.
Messiha
F S
FS
Department of Pharmacology, University of North Dakota School of Medicine, Grand Forks 58203.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis* / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000737:chemistry / Q000378:metabolism; D004298:Dopamine / Q000032:analysis* / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008526:Medulla Oblongata / Q000737:chemistry / Q000378:metabolism; D008636:Mesencephalon / Q000737:chemistry / Q000378:metabolism; D008715:Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D012701:Serotonin / Q000032:analysis* / Q000378:metabolism
D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008715:Methionine; D004298:Dopamine