Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor.
We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.
Vos
A
A
Department of Medical Genetics, State University of Groningen, The Netherlands.
Oosterhuis
J W
JW
de Jong
B
B
Castedo
S M
SM
Hollema
H
H
Buist
J
J
Aalders
J G
JG
D000328:Adult; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis*; D003884:Dermoid Cyst / Q000235:genetics / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008649:Mesonephroma / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
D004273:DNA, Neoplasm; D005819:Genetic Markers