[Study of the thrombolytic and fibrinolytic properties of thiol- dependent serine proteinase (TSP) from Thermoactinomyces vulgaris in vivo].
Experiments on male albino rats showed that the thyol-dependent serine proteinase (TSP) dissolved the thrombus in the jugular vein for 2-5 hr. Intravenous injection of TSP activated the fibrinolytic system of intact animals by increasing the levels of the plasminogen activator and plasmin in the euglobulin fraction. The response of the fibrinolytic system on the intravenous injection of TSP (2mg/200 g) was different: in some rats, fibrinolysis was activated, while on others, it was inhibited. TSP in high doses caused the death of 60% of experimental animals.
Liutova
L V
LV
Andreenko
G V
GV
Karabasova
M A
MA
Tsaplina
I A
IA
Rudenskaia
G N
GN
D000190:Actinomyces / Q000201:enzymology*; D000818:Animals; D005337:Fibrin / Q000378:metabolism*; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D051381:Rats; D012697:Serine Endopeptidases / Q000378:metabolism* / Q000627:therapeutic use; D012712:Serum Globulins / Q000378:metabolism; D013438:Sulfhydryl Compounds; D013917:Thrombin / Q000378:metabolism*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*
D012712:Serum Globulins; D013438:Sulfhydryl Compounds; D005337:Fibrin; D012697:Serine Endopeptidases; D013917:Thrombin
Izuchenie tromboliticheskikh i fibrinoliticheskikh svoĭstv preparata tiolzavisimoĭ serinovoĭ proteinazy (TSP) iz Termoactinomyces vulgaris v usloviiakh in vivo.