[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice].
When administered subcutaneously, ortho-aminoazotoluene induces predominantly liver tumours in A/HeJ mice but vascular tumours (located mainly in the interscapular brown fat pads) in CC57BR/Mv mice. Liver tumours are more frequent in females, while vascular tumours--in males. Under crossing, the susceptibility to induction of the both types of tumours in male F1 hybrids is inherited intermediately, whereas in females the resistance to induction of vascular tumours predominates.
Kaledin
V I
VI
Semenova
L A
LA
D000818:Animals; D001391:Azo Compounds; D004198:Disease Susceptibility; D005260:Female; D006390:Hemangioendothelioma / Q000139:chemically induced* / Q000473:pathology; D006394:Hemangiosarcoma / Q000139:chemically induced / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000473:pathology; D012737:Sex Factors; D009762:o-Aminoazotoluene
D001391:Azo Compounds; D009762:o-Aminoazotoluene
Retsiproknye razlichiia v chuvstvitel'nosti k induktsii orto-aminoazotoluonom opukholeĭ pecheni i sosudistykh opukholeĭ u mysheĭ liniĭ A/HeJ i CC67BR/Mv.