title: Inhibin is released together with testosterone by the human testis.
abstract: The secretion of inhibin by the testis into the circulation was studied by measuring immunoreactive inhibin concentrations in spermatic vein blood samples drawn at 15 min intervals for 4 h. Mean spermatic vein inhibin levels were four times the levels in peripheral blood whereas spermatic vein testosterone (T) levels were 60-fold increased. Inhibin was released in well-defined pulses which coincided with episodes ot T release; both the duration and relative amplitude of inhibin and T pulses were similar. Inhibin pulses were undetectable in peripheral blood. These data suggest that the mechanism responsible for releasing T from the testis also stimulates inhibin release. This mechanism appears to involve LH and Leydig cells.
authors.affiliation: Department of Medicine, Montefiore Hospital, Pittsburgh, PA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Winters
mesh_terms: D000328:Adult; D006801:Humans; D007265:Inhibins / Q000097:blood* / Q000378:metabolism; D007985:Leydig Cells / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D009845:Oligospermia / Q000097:blood; D013737:Testis / Q000098:blood supply* / Q000502:physiology; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D007265:Inhibins; D007986:Luteinizing Hormone