title: Antilaminin IgG releases TXB2 through activation of the cholinergic system.
abstract: Antilaminin IgG was bound to cholinergic muscarinic receptors of normal mice heart and released TXB2, simulating the biological effect of a cholinergic agonist. Antilaminin IgG interfered with the binding of the radiolabelled muscarinis antagonist (-)3H-QNB in a noncompetitive fashion. Following the interaction of the antibody with the cholinergic receptor, an increased production of TXB2 occurred. This effect required the activation of the muscarinic cholinergic system, because it was blunted by atropine and mimicked by acetylcholine.
authors.affiliation: Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Bacman
authors.forename: L
authors.initials: L
authors.lastname: Sterin-Borda
authors.forename: E
authors.initials: E
authors.lastname: Borda
mesh_terms: D000818:Animals; D006325:Heart Atria / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007797:Laminin / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011813:Quinuclidinyl Benzilate / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000502:physiology*; D013569:Synapses; D013929:Thromboxane B2 / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D007797:Laminin; D011950:Receptors, Cholinergic; D013929:Thromboxane B2; D011813:Quinuclidinyl Benzilate