title: Effects of cis-diamminedichloroplatinum (CDDP) and cis-diammine (1,1-cyclobutanedicarboxylate) platinum (CBDCA) on thermotolerance development and thermosensitivity of the thermotolerant cells.
abstract: The interactive effects of combined treatment with heat and CDDP (0.5 micrograms/ml) or CBDCA (10 micrograms/ml) were examined on the surviving fractions of V-79 cells. Both CDDP and CBDCA treatment induced a slight enhancement in thermosensitivity of thermotolerant cells. The development of thermotolerance during step-up heating was partially inhibited by simultaneous treatment with CDDP or CBDCA throughout the heating process. Simultaneous heat treatment at 42 degrees C with either drug showed marked interactive effect and inhibited the thermotolerance developed during 42 degrees C heating.
authors.affiliation: Department of Otorhinolaryngology, Fukui Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohtsubo
authors.forename: S W
authors.initials: SW
authors.lastname: Chang
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: P
authors.initials: P
authors.lastname: Picha
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: E
authors.initials: E
authors.lastname: Kano
mesh_terms: D000818:Animals; D016190:Carboplatin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D002999:Clone Cells / Q000187:drug effects; D003131:Combined Modality Therapy; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy; D009944:Organoplatinum Compounds / Q000494:pharmacology*
chemical_list: D009944:Organoplatinum Compounds; C055423:didimethylsulfoxide dichloroplatinum(II); D016190:Carboplatin