title: Long-lasting contact urticaria. Type I and type IV allergy from castor bean and a hypothesis of systemic IgE-mediated allergic dermatitis.
abstract: A unique urticarial type I patch-test reaction to castor bean that persisted for more than 48 hours and was followed by a delayed type IV reaction is described. Immunohistochemical and electron microscopic observations indicated involvement of eosinophils and IgE receptors on Langerhans' cells. The authors present a scheme for the role of Langerhans' cells in skin allergy.
authors.affiliation: Division of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Kanerva
authors.forename: T
authors.initials: T
authors.lastname: Estlander
authors.forename: R
authors.initials: R
authors.lastname: Jolanki
mesh_terms: D001706:Biopsy; D002367:Ricinus communis / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007801:Langerhans Cells / Q000276:immunology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D010947:Plants, Toxic; D012278:Ricinus / Q000276:immunology*; D014581:Urticaria / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E