[Paradoxic effect of anti-T-2 toxin antibodies in the curative treatment of acute poisoning in mice].
We have obtained polyclonal anti-T-2 toxin antibodies with high affinity to T-2 toxin (K = 0.34 x 10(9) l/M at 4 degrees C), crossreacting with HT-2 toxin, one of the major metabolites. We have assessed these antibodies in prevention and therapy of the acute intoxication. When given 24 h before 1 or 2 LD50 of T-2 toxin (5 or 10 mg/kg), the antibodies decreased the mortality from 67% to 37%, or from 100% to 83% respectively with an optimal antibody dosage of 100 mg/kg. In contrast when given 30 mn after the toxin, anti-T-2 toxin antibodies increased the mortality; in the same way non specific antibodies increased the mortality of mice intoxicated with T-2 toxin.
Vidal
D R
DR
Unité de Microbiologie, Centre de Recherches du Service de Santé des Armées, La Tronche.
Condemine
F
F
Falconnet
J B
JB
D000208:Acute Disease; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D005260:Female; D051379:Mice; D011041:Poisoning / Q000188:drug therapy* / Q000517:prevention & control; D013605:T-2 Toxin / Q000276:immunology*; D013997:Time Factors
D000906:Antibodies; D013605:T-2 Toxin
Effet paradoxal des anticorps anti-toxine T-2 dans le traitement curatif de l'intoxication aiguë de la Souris.