title: Amplify or improve detection.
abstract: Quantification with accuracy at the molecular level, by simple means, is the challenge for new generations of biospecific assays. In order to reach this goal, it is necessary to reduce the non-specific background of the current assays and further to amplify the detection signal or to expand the surface of the solid phase. For now, significant additions in performance can be achieved if we balance new ways of amplification with progressive improvements of existing procedures. For the future, new concepts derived form biosensors approach will lead to simultaneous multiple analysis on the same sample.
authors.affiliation: UMR 103, CNRS BioMérieux, Ecole Normale Supérieure de Lyon.
authors.forename: B
authors.initials: B
authors.lastname: Mandrand
authors.forename: J P
authors.initials: JP
authors.lastname: Yvert
mesh_terms: D001681:Biological Assay / Q000379:methods*; D015374:Biosensing Techniques; D011869:Radioligand Assay / Q000379:methods