Occupational asthma in a pharmaceutical worker exposed to hydralazine.
A pharmaceutical worker developed asthma when exposed to hydralazine, an antihypertensive drug. The diagnosis of occupational asthma was supported by specific inhalation challenges, which produced a late asthmatic reaction and an increase in bronchial responsiveness. No evidence of an IgE or an IgG dependent mechanism could be found.
Perrin
B
B
Department of Chest Medicine, Hôpital du Sacré-Coeur, West Gouin, Montreal, Canada.
Malo
J L
JL
Cartier
A
A
Evans
S
S
Dolovich
J
J
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000503:physiopathology; D004345:Drug Industry; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D007789:Lactose Tolerance Test; D008168:Lung / Q000503:physiopathology; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure
D006830:Hydralazine