title: Correlation between acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and total body fat content in mammals.
abstract: Single oral 30-day LD50s of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were correlated with total body fat (TBF) content in various species and strains of laboratory mammals. LD50 values and TBF contents were either obtained from the literature or determined by experiments. A log (LD50) vs. log (TBF) plot yielded a highly significant linear regression equation (r2 = 0.834, P less than 0.001, n = 20). It is suggested that this correlation exists for at least two reasons: (1) increasing TBF content in organisms represents an enhanced capacity to remove TCDD from the systemic circulation and (2) different TBF content reflects a differential role and regulation of fat metabolism for various organisms. Extrapolation of this correlation to man suggests that adult humans are among the less sensitive species to the acute toxicity of TCDD.
authors.affiliation: Institut für Okologische Chemie, Neuherberg, F.R.G.
authors.forename: H J
authors.initials: HJ
authors.lastname: Geyer
authors.forename: I
authors.initials: I
authors.lastname: Scheuntert
authors.forename: K
authors.initials: K
authors.lastname: Rapp
authors.forename: A
authors.initials: A
authors.lastname: Kettrup
authors.forename: F
authors.initials: F
authors.lastname: Korte
authors.forename: H
authors.initials: H
authors.lastname: Greim
authors.forename: K
authors.initials: K
authors.lastname: Rozman
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001835:Body Weight; D007928:Lethal Dose 50; D008322:Mammals; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D000072317:Polychlorinated Dibenzodioxins