Proteinases and the glomerulus: their role in glomerular diseases.
Degradation of matrix in normal glomeruli occurs through the action of neutral metalloproteinases which are in turn regulated by specific inhibitors. Both of these proteins are secreted by mesangial cells. Macrophages and IL-1 enhance the secretion of the proteinase. Decreased production of the metalloproteinase and for increased secretion of its inhibitor may lead to matrix accumulation. Neutrophil serine paternases degrade glomerular basement membrane (GBM) in vitro. In both animal and human disease urine excretion of these enzymes is accompanied by proteinuria and the presence of GBM-fragments. Further knowledge of the processes involved in matrix degradation may lead to improved therapy of glomerular disease.
Davies
M
M
Institute of Nephrology, University of Wales College of Medicine, Cardiff, United Kingdom.
Coles
G A
GA
Thomas
G J
GJ
Martin
J
J
Lovett
D H
DH
D001485:Basement Membrane / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005920:Glomerular Mesangium / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000201:enzymology; D007678:Kidney Glomerulus / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000378:metabolism*; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology; D012697:Serine Endopeptidases / Q000378:metabolism
D012697:Serine Endopeptidases; D008666:Metalloendopeptidases