title: Safety and efficacy of long-term tocolysis with indomethacin.
abstract: Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis. The mean gestational age at the start of indomethacin therapy was 25.1 weeks (+/- 4.4), mean duration of indomethacin therapy was 43.9 days (+/- 31.4), mean gestational age at delivery 33.1 weeks (+/- 3.7). Neonatal follow-up revealed the same incidence of complications in these indomethacin-exposed infants, when they were compared with all other infants born in the same time period and exposed to intravenous tocolytics only when matched for gestational age at delivery.
authors.affiliation: Section of Perinatology, Pennsylvania Hospital, Philadelphia.
authors.forename: A
authors.initials: A
authors.lastname: Gerson
authors.forename: S
authors.initials: S
authors.lastname: Abbasi
authors.forename: A
authors.initials: A
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Kalchbrenner
authors.forename: G
authors.initials: G
authors.lastname: Ashmead
authors.forename: R
authors.initials: R
authors.lastname: Bolognese
mesh_terms: D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors; D015145:Tocolysis
chemical_list: D007213:Indomethacin