title: [Continuous intrathecal baclofen therapy using an implantable pump system in severe spasticity].
abstract: Spasticity is an expression of a damage of the motor neurone associated with velocity dependent increase of the muscle tone. Since 1986 21 patients with severe spasticity mainly in multiple sclerosis were treated with an implantable pump system to administrate continuously Baclofen intrathecally. Even with a very small dosage of Baclofen patients who were previously treated until intoxication without success there was a favorable reduction in spasticity. Therefore we propose to perform this procedure before using surgical methods or stimulating methods.
authors.affiliation: Neurochirurgische Universitätsklinik, Christian-Albrechts-Universität Kiel.
authors.forename: W E
authors.initials: WE
authors.lastname: Braunsdorf
authors.forename: H D
authors.initials: HD
authors.lastname: Kuhlendahl
authors.forename: A
authors.initials: A
authors.lastname: Volkheimer
authors.forename: C
authors.initials: C
authors.lastname: Behrens
authors.forename: K
authors.initials: K
authors.lastname: Kleiter
mesh_terms: D001418:Baclofen / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015918:Infusion Pumps, Implantable; D009046:Motor Neurons / Q000187:drug effects; D009128:Muscle Spasticity / Q000188:drug therapy; D009460:Neurologic Examination; D010264:Paraplegia / Q000188:drug therapy*; D011782:Quadriplegia / Q000188:drug therapy*
chemical_list: D001418:Baclofen
vernacular_title: Kontinuierliche intrathecale Baclofen-Therapie mittels implantierbarer Pumpensysteme bei schwerer Spastik.