title: Hyperphosphatemia in infantile hypophosphatasia: implications for carrier diagnosis and screening.
abstract: Twenty obligate carriers of infantile hypophosphatasia (HOPS), a severe autosomal recessive metabolic bone disorder, were studied and compared with 36 controls. Decreased serum alkaline phosphatase activity and increased urinary phosphoethanolamine excretion were confirmed in the HOPS carriers. Relative hyperphosphatemia was documented for the first time in the carriers. Logistic regression analysis was used to develop models for the diagnosis of and screening for HOPS carriers in the high-risk population of Manitoba Mennonites. Models based on serum alkaline phosphatase activity and on serum phosphate levels with or without urinary phosphoethanolamine excretion were used for diagnostic purposes. A model based on serum alkaline phosphatase activity and on the serum phosphate level was the most suitable for screening.
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
authors.forename: B N
authors.initials: BN
authors.lastname: Chodirker
authors.forename: J A
authors.initials: JA
authors.lastname: Evans
authors.forename: L E
authors.initials: LE
authors.lastname: Seargeant
authors.forename: M S
authors.initials: MS
authors.lastname: Cheang
authors.forename: C R
authors.initials: CR
authors.lastname: Greenberg
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood* / Q000652:urine; D002118:Calcium / Q000097:blood; D004983:Ethanolamines / Q000652:urine*; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D007014:Hypophosphatasia / Q000175:diagnosis* / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D010710:Phosphates / Q000097:blood*; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D004983:Ethanolamines; D010710:Phosphates; C005448:phosphorylethanolamine; D000469:Alkaline Phosphatase; D002118:Calcium