Paternal occupation and anencephaly.
It has been suggested that paternal occupational exposures to pesticides and solvents increase the risk of neural tube defects in offspring. With the use of Texas livebirth, fetal death, and linked livebirth-death records, the authors conducted a population-based case-control study among 1981-1986 Texas births to examine the association between paternal occupation and anencephalic births. Fathers employed in occupations associated with solvent exposure were more likely to have offspring with anencephaly (odds ratio (OR) = 2.53), with painters having the highest risk (OR = 3.43). A lesser association was found for fathers employed in occupations involving pesticide exposure (OR = 1.28). Further studies are indicated to clarify these associations.
Brender
J D
JD
Environmental Epidemiology Program, Texas Department of Health, Austin.
Suarez
L
L
D000757:Anencephaly / Q000453:epidemiology / Q000209:etiology*; D001719:Birth Certificates; D016022:Case-Control Studies; D003644:Death Certificates; D004781:Environmental Exposure; D005220:Fathers; D006801:Humans; D007231:Infant, Newborn; D009790:Occupations; D010575:Pesticides / Q000009:adverse effects*; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects*; D013781:Texas
D010575:Pesticides; D012997:Solvents