title: [Nucleotide sequence of aacC2 gene from a clinical strain of Escherichia coli].
abstract: The nucleotide sequence of the aacC2 gene encoding ++aminoglycoside acetyltransferase AAC(3)-II was determined. The structural part of the 852-bp aacC2 gene encoded the protein with the molecular weight of 30.6 consisting of 286 amino acids. The promotor region and the structural part of the gene were compared with the known sequences of the aacC2 gene. Evolutionary changes in the regulatory region as well as a number of nucleotide substitutes in the structural part of the gene and amino acid substitutes in the enzyme molecule were detected.
authors.forename: S B
authors.initials: SB
authors.lastname: Vakulenko
authors.forename: E G
authors.initials: EG
authors.lastname: Entina
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D001483:Base Sequence; D015247:Deoxyribonuclease HindIII / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase; D015247:Deoxyribonuclease HindIII
vernacular_title: NUkleotidnaia posledovatel'nost' gena aacC2 iz klinicheskogo shtamma Escherichia coli.