title: In vitro study of clonazepam diffusion kinetics from solutions or hydrophilic gel.
abstract: Preliminary studies were conducted to evaluate the influence of temperature, pH and ionic strength of the donor and receptor medium on the solubility, partition coefficient and diffusion rate of clonazepam across a lipophilic artificial membrane, in view of future setting up of transdermal formulation of this drug. The in vitro release of clonazepam from a carbopol hydrogel was also investigated.
authors.affiliation: Dipartimento di Scienze farmaceutiche, Univ. Firenze, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mura
authors.forename: A
authors.initials: A
authors.lastname: Liguori
authors.forename: G
authors.initials: G
authors.lastname: Bramanti
authors.forename: P
authors.initials: P
authors.lastname: Corti
authors.forename: C
authors.initials: C
authors.lastname: Murratzu
authors.forename: L
authors.initials: L
authors.lastname: Celesti
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002998:Clonazepam / Q000737:chemistry* / Q000493:pharmacokinetics; D004058:Diffusion; D005782:Gels; D012996:Solutions
chemical_list: D005782:Gels; D012996:Solutions; D002998:Clonazepam