[Elastase activity during growth and metastasis of tumors andthe pharmacological effects in C57Bl/6 mice].
The elastase activity in malignant tumour tissues and lungs of C57B1/6 mice has been studied under growth and metastatic spreading of tumours and under some pharmacological influences (tryelin, cyclophosphamide). The highest elastase activity was revealed in mice with carcinoma 3LL, especially in the period of formation and appearance of metastases. Tryelin alone and in combination with cyclophosphamide reduces the elastase activity and inhibits the process of metastatic spreading in lungs.
Chubinskaia
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D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000556:secondary; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D008546:Melanoma, Experimental / Q000201:enzymology* / Q000473:pathology / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control; D010196:Pancreatic Elastase / Q000032:analysis* / Q000037:antagonists & inhibitors; D011407:Propane / Q000031:analogs & derivatives; D011480:Protease Inhibitors / Q000494:pharmacology*; D013997:Time Factors
D011480:Protease Inhibitors; C012076:trielin; D003520:Cyclophosphamide; D010196:Pancreatic Elastase; D011407:Propane
Aktivnost' élastazy pri roste, metastazirovanii opukholeĭ i nekotorykh farmakologicheskikh vozdeĭstviiakh u mysheĭ linii C57Bl/6.