Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation.
Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.
Ti
T I
TI
Department of Pharmacology, Faculty of Medicine, National University of Singapore.
Monteiro
E H
EH
Lam
S
S
Lee
H S
HS
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002701:Chloramphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D014435:Typhoid Fever / Q000097:blood* / Q000188:drug therapy
D002701:Chloramphenicol; C026016:chloramphenicol succinate