[The survival of patients with mesangial immunoglobulin A glomerulonephritis].
68 patients with immunoglobulin A glomerulonephritis (IgA-GN) were studied. 67.4% of them were men. The most frequent clinical manifestation is the microscopical hematuria--in 39.7% of the patients. A single episode of macroscopic hematuria was found in 32.3% of the patients and recurrent macroscopic hematuria--in 25% of the patients. Proteinuria was found in all patients but nephrotic syndrome--only in one patient. At the time of the biopsy 35.5% of the patients were with hypertension, 13.2%--with initial chronic renal failure. The survival of the patients with IgA--GN, assessed according to the registration life tables, was 93% at the 5-th year, 88% at the 10-th year and 70.6% at the 20-th year. It was statistically higher in the patients without hypertension. Among the patients with proteinuria below 1.0/24 h no one reached terminal chronic renal failure. The male sex was a factor for a statistically shorter survival only at the 20-th year. The survival of the patients with insignificant histological changes was 100% for the period of the study, whereas it was significantly lower for the other histological variants. According to the data of the study, the presence of arterial hypertension, proteinuria above 1.0 g/24 h, a more severe histological variant (focal-segment, diffuse proliferative and particularly sclerotic), and to a certain degree the male sex play an unfavorable role in the survival and determine a poorer prognosis for the patients with IgA-GN.
Belovezhdov
N
N
Robeva
R
R
Dimitrova
V
V
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002031:Bulgaria; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000401:mortality*; D006417:Hematuria / Q000401:mortality; D006801:Humans; D006973:Hypertension / Q000401:mortality; D007676:Kidney Failure, Chronic / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria / Q000401:mortality; D012737:Sex Factors; D016019:Survival Analysis
Prezhiviaemost pri bolnite s mezangealen imunoglobulin A glomerulonefrit.