title: Relationship between leukocytic infiltration and endothelial specialization in murine cardiac allografts.
abstract: We have used immunologic and histologic techniques to analyze the rejection of heterotopic murine cardiac allografts. These studies were designed to test the hypothesis that lymph-node-like mechanisms of lymphocyte extravasation develop in immediately vascularized organ allografts during the process of rejection. The experimental results suggest that lymph-node-like mechanisms are not involved, and that an unexpected pattern of lymphocyte infiltration develops in these allografts.
authors.affiliation: Department of Surgery, Ohio State University College of Medicine, Columbus 43210.
authors.forename: D M
authors.initials: DM
authors.lastname: Leppink
authors.forename: D K
authors.initials: DK
authors.lastname: Bishop
authors.forename: D D
authors.initials: DD
authors.lastname: Sedmak
authors.forename: C G
authors.initials: CG
authors.lastname: Orosz
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA