Localization of the growth hormone gene to the distal half of mouse chromosome 11.
A DNA fragment size variant for the growth hormone gene, Gh, has been identified among inbred strains of mice. The inbred strains SM/J and CAST/Ei carry the less frequent allele Ghb and 11 other strains carry the Gha allele. Segregation analysis of data from two crosses involving SM/J and NZB/BINJ and a cross involving BALB/cJ and CAST/Ei confirmed the assignment of Gh to mouse chromosome 11 and placed the locus 2.6 +/- 1.8 map units distal to Erba (avian erythroblastosis oncogene A), a position consistent with the assignment of the Gh locus to the q22-q24 region of chromosome 17 on the human map. Segregation analysis also refined the location of Sparc (secreted acidic cysteine-rich glycoprotein) on mouse chromosome 11 to a position 16.7 +/- 4.2 map units proximal to Evi-2 (ecotropic viral integration site 2).
Elliott
R W
RW
Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 14263.
Lee
B K
BK
Eicher
E M
EM
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D011995:Recombination, Genetic; D013045:Species Specificity
D005819:Genetic Markers; D013006:Growth Hormone