title: [Antioxidation and membrane-stabilizing therapy of hypoxic conditions in newborn infants].
abstract: It has been found that a most important mechanism underlying the development of various pathological conditions in the organism of neonates with perinatal hypoxic lesions of the central nervous system is the structural and functional disorganization of the cell membranes. This is associated with activation of lipid peroxidation, effect of lysosomal enzymes, and impairment of antioxidative defense. As a result, the membrane content of most important lipids is changed, their degenerative forms appear, lipoperoxides accumulate, and the activity of the membrane enzymes is inhibited. The obtained evidence serves the basis for a wide-scale application of the membranotrophic therapy for hypoxic CNS lesions in the neonates.
authors.forename: S Sh
authors.initials: SSh
authors.lastname: Shamsiev
authors.forename: V I
authors.initials: VI
authors.lastname: Krylov
authors.forename: F S
authors.initials: FS
authors.lastname: Shamsiev
mesh_terms: D000975:Antioxidants; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D014494:Unithiol / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*; D014811:Vitamin E Deficiency / Q000150:complications / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D014494:Unithiol
vernacular_title: Antioksidantnaia i membranostabiliziruiushchaia terapiia gipoksi- cheskikh sostoianiĭ u novorozhdennykh.