title: Effects of dietary iodine on chemical induction of thyroid carcinoma.
abstract: Effects of dietary iodine on the induction of thyroid carcinoma using N-nitrosobis(2-hydroxypropyl)amine (BHP) were studied. Male Wistar rats were fed with an iodine-adequate diet (IAD group), an iodine-rich diet (IRD group) and an iodine-deficient diet (IDD group), respectively, until the time of sacrifice. From the 2nd experimental month, animals were injected with BHP once a week for 10 weeks. In the IAD and IRD groups, benign nodules and papillary carcinoma were found. The incidence of rats with benign nodules was 100% in both groups and animals with papillary carcinoma in the IAD and IRD groups comprised 33% and 29%, respectively. The area of the thyroid gland occupied by nodular lesions was much narrower in the IRD group than in the IAD group. In the IDD group, the thyroid showed marked enlargement due to multiple nodular proliferation of follicle cells. The incidence of rats with carcinoma was 100%, and not only papillary but also follicular carcinoma and one pulmonary metastasis were found. As the iodine content of the diet decreased, the nodular lesions increased in width and number, and the incidence of carcinoma in rats became higher. These effects of dietary iodine are probably related to the goitrogenic and/or promoting effects of TSH.
authors.affiliation: Department of Pathology, Medical College of Oita, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: R
authors.initials: R
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: I
authors.initials: I
authors.lastname: Nakayama
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D002291:Carcinoma, Papillary / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D004032:Diet; D004305:Dose-Response Relationship, Drug; D015994:Incidence; D007455:Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; C012457:diisopropanolnitrosamine; D007455:Iodine