Fulminant hepatic failure associated with intravenous erythromycin lactobionate.
Fatal fulminant hepatic failure accompanied by brisk hemolysis developed in an elderly man after intravenous administration of erythromycin lactobionate for a lower respiratory infection. To our knowledge, this is the first case of fatal hepatotoxicity associated with intravenous erythromycin therapy. Erythromycin should be added to the list of drugs that can cause fulminant hepatic failure.
Gholson
C F
CF
Department of Medicine, St Francis Medical Center, Cape Girardeau, Mo.
Warren
G H
GH
D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D004917:Erythromycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; C010948:erythromycin lactobionate; D004917:Erythromycin