CAF-603: a new antifungal carotane sesquiterpene. Isolation and structure elucidation.
A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.
Watanabe
N
N
Research Institute, Taisho Pharmaceutical, Saitama-ken, Japan.
Yamagishi
M
M
Mizutani
T
T
Kondoh
H
H
Omura
S
S
Hanada
K
K
Kushida
K
K
D000935:Antifungal Agents / Q000302:isolation & purification*; D002176:Candida albicans / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000032:analysis*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000494:pharmacology*
D000935:Antifungal Agents; D012717:Sesquiterpenes; C067644:CAF 603