title: Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor.
abstract: We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.
authors.affiliation: Department of Medical Genetics, State University of Groningen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Vos
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: B
authors.initials: B
authors.lastname: de Jong
authors.forename: S M
authors.initials: SM
authors.lastname: Castedo
authors.forename: H
authors.initials: H
authors.lastname: Hollema
authors.forename: J
authors.initials: J
authors.lastname: Buist
authors.forename: J G
authors.initials: JG
authors.lastname: Aalders
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis*; D003884:Dermoid Cyst / Q000235:genetics / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008649:Mesonephroma / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers