Daily profiles of salivary cortisol in hydrocortisone treated children with congenital adrenal hyperplasia.
Daily profiles of salivary cortisol were determined in 14 cortisol-treated children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, and in 5 healthy sibs. The results showed considerable individual variation irrespective of the dose of hormone, reflecting the different rates of cortisol metabolism and transport. Maximum salivary cortisol levels were reached 1-2 h following oral administration of hydrocortisone. The determination of salivary cortisol may be useful for optimal dosage timing, i.e. to imitate the daily rhythm of normal cortisol secretion.
Hampl
R
R
Research Institute of Endocrinology, Praha, Czechoslovakia.
Foretová
L
L
Sulcová
J
J
Stárka
L
L
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000188:drug therapy / Q000378:metabolism*; D000735:Androstenedione / Q000031:analogs & derivatives / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D006908:Hydroxyprogesterones / Q000097:blood; D008297:Male; D012044:Regression Analysis; D012463:Saliva / Q000032:analysis*
D006908:Hydroxyprogesterones; D000735:Androstenedione; C003582:11-hydroxyandrostenedione; D019326:17-alpha-Hydroxyprogesterone; D006854:Hydrocortisone