Tryptophan metabolic studies in patients with presenile cataracts.
In 43 patients with presenile cataracts an oral tryptophan loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of kynurenine and xanthurenic acid was determined. 5 cases showed pathological deviations and an excretion pattern of tryptophan metabolites via kynurenine, similar as in vitamin B6-dependent xanthurenic aciduria.
Grimm
U
U
Department of Ophthalmology, Ernst-Moritz-Arndt University, Greifswald, GDR.
Knapp
A
A
Seidlitz
G
G
Franke
G
G
Mellenthin
R
R
D000293:Adolescent; D000328:Adult; D002386:Cataract / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007737:Kynurenine / Q000652:urine; D008297:Male; D011736:Pyridoxine / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism*; D014977:Xanthurenates / Q000652:urine
D014977:Xanthurenates; D007737:Kynurenine; C028330:xanthurenic acid; D014364:Tryptophan; D011736:Pyridoxine