Macromastia in a woman treated with penicillamine and oral contraceptives. A case report.
A patient with Wilson's disease treated with penicillamine developed severe hirsutism. After treatment with oral contraceptives, her breasts enlarged rapidly, and she experienced cyclic mastodynia. Around the time of her breast enlargement she also developed gingival hyperplasia.
Rose
B I
BI
Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida.
LeMaire
W J
WJ
Jeffers
L J
LJ
D000328:Adult; D001940:Breast / Q000187:drug effects* / Q000473:pathology; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000627:therapeutic use; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006628:Hirsutism / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D009640:Norethindrone / Q000009:adverse effects / Q000627:therapeutic use; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; C020416:norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination; D004997:Ethinyl Estradiol; D010396:Penicillamine; D009640:Norethindrone