Focal glomerular sclerotic lesions in a patient with unilateral oligomeganephronia and agenesis of the contralateral kidney: a case report.
An open renal biopsy specimen from a twelve-year-old boy with a congenital solitary kidney was studied with light, electron, and fluorescent microscopy. Focal glomerular sclerotic lesions were disclosed by these microscopic examinations. Morphometric analysis revealed statistically significant hypertrophy of the glomeruli and significant reduction in the number of glomeruli when compared with controls of similar age. These findings suggested that not only the loss of one kidney, but also congenital reduction of nephrons contributed to the development of focal glomerular sclerotic lesions in this patient. There have been five reported cases of unilateral renal agenesis with oligomeganephronia in a solitary kidney [Van Acker et al. 1971, Griffel et al. 1972, Lam et al. 1982, Bhathena et al. 1985]. Our case, therefore, would be the sixth such case.
Nomura
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Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Osawa
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G
D001706:Biopsy; D002648:Child; D005921:Glomerulonephritis / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D007668:Kidney / Q000002:abnormalities*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009399:Nephrons / Q000473:pathology*