title: Evidence for the presence of angiotensin II-type 1 receptors in brain.
abstract: Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND 58103.
authors.forename: J K
authors.initials: JK
authors.lastname: Wamsley
authors.forename: W F
authors.initials: WF
authors.lastname: Herblin
authors.forename: M E
authors.initials: ME
authors.lastname: Alburges
authors.forename: M
authors.initials: M
authors.lastname: Hunt
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D007093:Imidazoles; D007457:Iodine Radioisotopes; D019808:Losartan; D008297:Male; D011725:Pyridines; D051381:Rats; D011945:Receptors, Angiotensin / Q000737:chemistry*; D013777:Tetrazoles
chemical_list: D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D007457:Iodine Radioisotopes; D011725:Pyridines; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; C066253:PD 123177; D019808:Losartan