Radionuclide detection of gastroesophageal reflux in children suffering from recurrent lower respiratory tract infection.
Radionuclide gastro-esophageal scintigraphy was performed on 25 control and 183 children suffering from recurrent lower respiratory tract infection. Gastro-esophageal reflux (GER) of varying grades was observed in 135 patients. The severity of clinical symptoms in the patients was found to be directly related to the severity of reflux observed in the radionuclide study. In some patients an attempt was also made to quantitate GER by calculating the Gastro-esophageal reflux index. The results of the scintigraphic study were correlated with the results of the other commonly used and more conventional Barium swallow and fluoroscopy study. Gastro-esophageal scintigraphy was found to be much superior in terms of sensitivity, specificity and accuracy in detecting GER. It was also possible to objectively evaluate and monitor response to treatment following conservative or corrective surgical therapy using the radionuclide technique. The results of the study demonstrated a remarkably high incidence of GER in the patients. Whether GER is the cause of recurrent lower respiratory tract infection or not is difficult to establish firmly. But within the preview of the study the association seems to be very strong and cannot be easily ignored.
Padhy
A K
AK
Department of Nuclear Medicine, Internal Medicine and Pediatrics, All India Institute of Medical Sciences, New Delhi.
Gopinath
P G
PG
Sharma
S K
SK
Prasad
A K
AK
Arora
N K
NK
Tiwari
D C
DC
Gupta
K
K
Chetty
A
A
D002648:Child; D002675:Child, Preschool; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008297:Male; D011877:Radionuclide Imaging; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology*