HLA antigens in tardive dyskinesia.
Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD (n = 25) was compared to the group without TD (n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed.
Metzer
W S
WS
Department of Neurology, University of Arkansas for Medical Sciences, Little Rock.
Newton
J E
JE
Steele
R W
RW
Claybrook
M
M
Paige
S R
SR
McMillan
D E
DE
Hays
S
S
D004409:Dyskinesia, Drug-Induced / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D015804:HLA-DR4 Antigen