title: [Immunoscintigraphy of malignant melanoma].
abstract: This work is part of a multicentric European evaluation of the monoclonal antibody 225.28s targeted against malignant melanoma and its metastases. Twenty-eight patients (12 males, 16 females, mean age: 53 yrs), who had initially been treated by resection of the primary tumour, were included in the study. Twenty-three of the 26 metastases more than 1 cm in diameter were visualized by immunoscintigraphy. The sensitivity of the procedure (88%) is limited however by the small size of the lesions and their depth, as well as by background noise caused by circulating antibodies. Immunoscintigraphy enables non-invasive investigation of the whole body and can detect lesions that other conventional complementary explorations fail to identify.
authors.affiliation: Service de Médecine Nucléaire, CHU Rennes, France.
authors.forename: L
authors.initials: L
authors.lastname: Nicol
authors.forename: A
authors.initials: A
authors.lastname: Sandron
authors.forename: J Y
authors.initials: JY
authors.lastname: Herry
authors.forename: J
authors.initials: J
authors.lastname: Chevrant-Breton
mesh_terms: D000911:Antibodies, Monoclonal; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008545:Melanoma / Q000000981:diagnostic imaging*; D015337:Multicenter Studies as Topic; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Immunoscintigraphie des mélanomes malins.