Human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113).
Seven male volunteers were exposed to atmospheric concentrations of either 1980, 4100 or 7630 mg m-3 1,1,2-trichloro-1,2,2-trifluoroethane (FC113) for 4 h. Blood and expired air samples were collected during the exposure period and for several days subsequently and analysed for FC113. Blood and breath concentrations of FC113 were related to the administered dose with some variation between individuals. The low blood/breath ratios measured are consistent with the low solubility of FC113 in blood. The absorption and elimination of FC113 can be described by a three-compartment model and the average half-lives of elimination of FC113 in breath were 0.22, 2.3 and 29 h. A pulmonary retention during the exposure period of 14% was measured but only 2.6 to 4.3% of the dose was recovered unchanged in breath after the exposure period, suggesting that FC113 could be metabolised following inhalation exposure. It is concluded that a practical method for biological monitoring during occupational exposure would be to measure end-tidal breath concentrations of FC113 in samples taken the morning after exposure. The predictive value of such a measurement can be improved if the results are normalised to the body fat content of individual workers which can be estimated from height and weight measurements.
Woollen
B H
BH
Human Toxicology Team, ICI Central Toxicology Laboratory Alderley Park, Cheshire, England.
Guest
E A
EA
Howe
W
W
Marsh
J R
JR
Wilson
H K
HK
Auton
T R
TR
Blain
P G
PG
D000280:Administration, Inhalation; D000395:Air Pollutants, Occupational / Q000032:analysis; D001944:Breath Tests; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
D000395:Air Pollutants, Occupational; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; C005850:1,1,1-trichloro-2,2,2-trifluoroethane