title: [Synthesis of N-(2-mercaptopyridyl-3-formyl)-N-alkyl glycine and the corresponding disulfides].
abstract: N-(2-mercaptopyridyl-3-formyl)-N-alkyl glycine I1-8) were synthesized by the condensation of 2-mercaptopyridyl-3-formyl chloride with ethyl N-alkyl glycinate followed by hydrolysis. The corresponding disulfides (II1-7) were obtained by the oxidation of compounds I1-7 with hydrogen peroxide (1%) in weak alkali medium below 10 degrees C. In preliminary tests, some compounds showed inhibitory activity of ACE in vitro.
authors.affiliation: Division of Medicinal Chemistry, China Pharmaceutical University, Nanjing.
authors.forename: Y L
authors.initials: YL
authors.lastname: Luo
authors.forename: Z X
authors.initials: ZX
authors.lastname: Yang
authors.forename: S X
authors.initials: SX
authors.lastname: Peng
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D011725:Pyridines; D005998:Glycine