[Effects of a cardiac peptide preparation on the myocardium in ischemia].
Based on experimental studies the possibility of cordialin use in acute ischemia is being substantiated. On the first day of the animals' mortality and increased life duration of cells in ischemia zone, delaying the injury region expansion. But later in rats, that were given cordialin, slowing down of injury zone recovery and scar tissue formation was demonstrated. Cordialin use in early stages of myocardial infarction is suggested. In experiments on isolated heart cordialin is reported to decrease the intensity of processes of lipids' peroxide oxidation in intact and ischemic myocardium. But in reperfusion cordialin activates LPO, that is associated with heart contracting activity inhibition. The results of the study may serve as an experimental basis for cordialin use on the first day of MI development. Its further use needs the correction of its ability to slow down the processes of necrotic tissue recovery.
Pavlenko
V S
VS
Andreeva
L I
LI
Khavinson
V Kh
VKh
Khlystov
V V
VV
Gutsol
A A
AA
D000818:Animals; D001706:Biopsy; D002317:Cardiovascular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D036341:Intercellular Signaling Peptides and Proteins; D008315:Malondialdehyde / Q000032:analysis; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C067671:cordialin; D008315:Malondialdehyde
Vliianie peptidnogo preparata iz serdtsa na miokard v usloviiakh ishemii.