The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.
A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.
Blundell
T L
TL
Department of Crystallography, Birkbeck College, London, UK.
Lapatto
R
R
Wilderspin
A F
AF
Hemmings
A M
AM
Hobart
P M
PM
Danley
D E
DE
Whittle
P J
PJ
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D016333:HIV Protease / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010434:Pepsin A / Q000235:genetics; D011480:Protease Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D011487:Protein Conformation
D000998:Antiviral Agents; D011480:Protease Inhibitors; D016333:HIV Protease; D010434:Pepsin A