title: [Effects of cigarette smoking on I-123 IMP clearance from the lung].
abstract: N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP), originally developed as a brain scanning agent, is also taken up by the lung. To evaluate the cigarette smoking on the uptake of IMP by the lung, we studied I-123 IMP clearance from the lung of 14 volunteers; 5 non-smokers and 9 smokers. After the injection of 111 MBq (3 mCi) of I-123 IMP into the medial cubital vein, the time-activity curve for 60 minutes and the regional activity using 1 frame per minute and a 64 x 64 matrix was obtained. I-123 IMP clearance curve was described as follows: C(t) = A1e-k1t + A2e-k2t (A1, A2: intercepts, and k1, k2: slopes of the exponential components). I-123 IMP clearance was delayed in smokers, and k2 was smaller in smokers. Also a significant correlations between k1, k2, and the number of cigarettes smoked per day were found. In conclusion, this study suggests that the delayed clearance and retention of I-123 IMP in the lung indicate the lung metabolic disorders due to cigarette smoking.
authors.affiliation: Department of Radiology, Iwate Medical University.
authors.forename: K
authors.initials: K
authors.lastname: Katoh
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000662:Amphetamines / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D020367:Iofetamine; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008954:Models, Biological; D011877:Radionuclide Imaging; D012907:Smoking / Q000009:adverse effects*
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine