title: [Endoscopic polypectomy and adenoma-carcinoma sequence of the large intestine. Considerations on personal case series].
abstract: Since the introduction of colonoscopic polypectomy, the management of colonic polyps has dramatically changed. What once was a major transabdominal operation now is a routine therapeutic endoscopic procedure. To test the hypothesis of the adenoma-carcinoma sequence histopathologic features of polypoid lesions are retrospectively evaluated. In our experience with 566 polypectomies 430 adenomatous polyps, 71 hyperplastic, 58 inflammatory polyps, and 4 juvenile lesions are reported. Only adenomatous polyps showed dysplasia. Overall, severe and moderate dysplasia was respectively observed in 6.7% and 23% of the adenomas. Infiltrating carcinoma was present in 2.2% of the cases. Villous adenomas showed high rates of severe dysplasia (37%) and invasive carcinoma (18%). Location and sex did not seem to have a role in the malignant potential of adenomas.
authors.affiliation: Cattedra di Semeiotica Chirurgica, II Università degli Studi Tor Vergata, Roma.
authors.forename: V M
authors.initials: VM
authors.lastname: Stolfi
authors.forename: D
authors.initials: D
authors.lastname: Bacaro
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: D
authors.initials: D
authors.lastname: Quintigliano
authors.forename: C
authors.initials: C
authors.lastname: Spina
authors.forename: M P
authors.initials: MP
authors.lastname: Canale
authors.forename: E
authors.initials: E
authors.lastname: Gentileschi
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D002430:Cecal Neoplasms / Q000473:pathology / Q000601:surgery; D002432:Cecum / Q000473:pathology; D003106:Colon / Q000473:pathology; D012809:Colon, Sigmoid / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology / Q000601:surgery*; D008297:Male; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012007:Rectum / Q000473:pathology; D012189:Retrospective Studies; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery
vernacular_title: Polipectomia endoscopica e sequenza adenoma-carcinoma nel grosso intestino. Considerazioni su casistica originale.