title: Red cell glucose-6-phosphate dehydrogenase phenotypes in several Mongoloid populations of eastern India: existence of a non-deficient fast variant in two Australasian tribes.
abstract: A total of 954 subjects of both sexes from nine Mongoloid tribes of eastern India were investigated for the distribution of red cell glucose-6-phosphate dehydrogenase (G6PD) phenotypes by starch-gel electrophoresis. The incidence of Gd- was found to be 8% in the Khasi, 6% in the Nishi, 5% in Apatani and 3% in Adi. The small group of Bodo and the mixed group of other Arunachal tribes had Gd- frequencies of 19% and 15%, respectively. Only one isolated incidence of Gd- was encountered in the Naga, while the Hmar lacked Gd-. The Khasi had a polymorphic frequency (about 4%) of a non-deficient fast variant (GdV) (105% mobility in TEB buffer of pH 8.6). Two heterozygotes of this allele with a combination of common GdB+ were detected in two females. Interestingly, the same allele was reported earlier in another Australasian tribe--the Korkus of central India.
authors.affiliation: Department of Paediatrics, National University of Singapore.
authors.forename: N
authors.initials: N
authors.lastname: Saha
authors.forename: S H
authors.initials: SH
authors.lastname: Hong
authors.forename: H A
authors.initials: HA
authors.lastname: Wong
authors.forename: J S
authors.initials: JS
authors.lastname: Tay
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D004592:Electrophoresis, Starch Gel; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007194:India; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D005954:Glucosephosphate Dehydrogenase