title: Presence of Helicobacter pylori in patients with non-ulcer dyspepsia revealing normal antral histological characteristics.
abstract: Two hundred consecutive patients suffering from non-ulcer dyspepsia were studied for the presence of Helicobacter pylori in antral gastritis and normal antral mucosa, using the combination of culture, modified Giemsa stain and a sensitive immunoperoxidase stain as means of detection. H. pylori gastritis was present in 56% of the cases. The bacterium was present in 75% of cases of normal antral mucosa, however, in low numbers. It is concluded that 87% of patients with non-ulcer dyspepsia are H. polory-positive implying a larger role for the micro-organism as initially thought.
authors.affiliation: Department of Internal Medicine, University Hospital Maasstricht, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Loffeld
authors.forename: E
authors.initials: E
authors.lastname: Stobberingh
authors.forename: J A
authors.initials: JA
authors.lastname: Flendrig
authors.forename: J W
authors.initials: JW
authors.lastname: Arends
mesh_terms: D001706:Biopsy; D004415:Dyspepsia / Q000382:microbiology*; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged