[Results of total androgenic blockade for the treatment of disseminated cancer of the prostate].
Following Labrie's idea, during the last three and a half years about 35 stage D patients were treated with Total Androgenic Blockade, while Radiotherapy and adjuvant TAB was used in 7 stage C patients. Subjective response rate in stage D was 86%. In 46% of the cases there was some sort of objective response (either partial or complete). After 43 months the actual survival rate is 34%. These results show no improvement from other series, but the inclusion of patients with little life expectancy should be taken into account. Results obtained in stage C, though very few patients were included in the series, were good, and patients currently alive remain free from local and metastatic illness. Since the number of patients was reduced, no conclusion can be drawn. In view of the disease progression, Estracyt was used as a second line therapy. Results have been poor showing some subjective, but no objective, response usually of short duration, in all patients (5 cases) undergoing such therapeutic procedure.
Miján Ortiz
J L
JL
Departamento de Cirugía, Hospital Clínico Universitario, Granada, España.
Zuluaga Gómez
A
A
García Víctor
F
F
Martínez Torres
J L
JL
Haddad Campos
A
A
D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D000726:Androgen Antagonists
Resultados obtenidos con el bloqueo androgénico total en el tratamiento del cáncer de próstata diseminado.