Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.
This report summarizes data on the induction, repair and biological relevance of five types of radiation-induced DNA lesions for which repair kinetic studies have been performed in eukaryotic cells by various laboratories. These lesions are: DNA-protein crosslinks, base damage, single-strand breaks, double-strand breaks and bulky lesions (clustered base damage in the nm-range). The influence of various factors, such as oxia/anoxia, linear energy transfer of the radiation used, incubation medium, cell cycle stage, thiol content, hyperthermia, on the induction and repair of these lesions is described. Radiation-sensitive cell lines are also included.
Frankenberg-Schwager
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Gesellschaft für Strahlen- und Umweltforschung mbH, Institut für Biophysikalische Strahlenforschung, Frankfurt, Federal Republic of Germany.
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair / Q000502:physiology*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000528:radiation effects; D005057:Eukaryotic Cells / Q000502:physiology / Q000528:radiation effects*; D009711:Nucleotides / Q000528:radiation effects
D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D009711:Nucleotides; D004247:DNA