Molecular recognition in allergic contact dermatitis. The concept of double-headed haptens.
The sensitizing capacity of double-headed haptens containing the pyrocatechol and alpha-methylene-gamma-butyrolactone groups reveals that only the pyrocatechol end is recognized as a sensitizer. Prior sensitization to the double-headed hapten provides protection against (induces immune tolerance to) further sensitization to the lactone hapten.
Benezra
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Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France.
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000276:immunology; D000818:Animals; D002396:Catechols / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000276:immunology*; D006168:Guinea Pigs; D006241:Haptens / Q000276:immunology*; D007108:Immune Tolerance
D002396:Catechols; D006241:Haptens; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone