[The so-called herpes gestationis factor in bullous pemphigoid].
We have investigated the presence of the so-called "herpes gestationis factor" in the serum of fifteen patients with bullous pemphigoid and one patient with cicatricial pemphigoid, that were negative for circulating anti-basement membrane antibodies, using the complement fixation test (substrate: human normal skin, 0 group). We have found herpes gestationis factor in 30% of the serologically negative patients. The presence in the serum of an auto-antibody IgG1 (HGF) highly avid for complement, may determine the false serological negativity in this patient.
Fuligni
A
A
Clinica Dermosifilopatica I, Università di Firenze.
Geti
V
V
Di Blasi
A
A
Cottoni
F
F
Fabbri
P
P
D001323:Autoantibodies / Q000032:analysis*; D003168:Complement Fixation Tests; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D006559:Pemphigoid Gestationis / Q000276:immunology*; D010390:Pemphigoid, Benign Mucous Membrane / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000276:immunology*; D011247:Pregnancy
D001323:Autoantibodies; D007074:Immunoglobulin G
Il cosiddetto herpes gestationis factor nel pemfigoide bolloso.