[The effects of vinburnine on the blood rheology parameters and on the oxyhemoglobin dissociation curve and 2,3-diphosphoglycerate. In vitro research].
The authors investigate the protective action of vinburnine on impairment of blood haemorheology and on metabolic parameters due to in vitro ageing of blood samples. In each sample the following parameters were measured: blood viscosity and filterability, p50 and 2,3-DPG. Vinburnine is able to induce a slight improvement of haemorheological parameters and of p50 compared to controls. After incubation for 4 hr, a reduced impairment of the mentioned parameters was observed in comparison with controls. Some hypotheses are discussed about the mechanisms of action of the drug.
Acciavatti
A
A
Istituto di Patologia speciale medica e Metodologia clinica, Università, Siena.
Domini
L
L
Galigani
C
C
Saletti
M
M
Guideri
F
F
Auteri
A
A
Di Perri
T
T
D019794:2,3-Diphosphoglycerate; D001809:Blood Viscosity / Q000187:drug effects*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D010108:Oxyhemoglobins / Q000378:metabolism*; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; D019794:2,3-Diphosphoglycerate; C016422:eburnamonine
Effetti della vinburnina sui parametri emoreologici e sulla curva di dissociazione ossiemoglobinica e 2-3 difosfoglicerato. Ricerche in vitro.