Antibacterial effect of zinc oxide in vitro.
Antibacterial activity, zinc concentrations and pH were measured in Müller-Hinton broth containing different amounts of zinc oxide and inoculated with Staphylococcus aureus (10(6) colony forming units/ml). The minimum inhibitory concentrations (MIC) of zinc oxide to different clinical isolates were determined using the Müller-Hinton agar dilution tests. Gram-positive bacteria were most susceptible. Gram-negative aerobic bacteria and streptococci were usually not inhibited even at the highest concentrations used (1024 micrograms/ml), but staphylococci--particularly some isolates of Staphylococcus epidermidis--were sensitive enough to allow determination of their MIC.
Söderberg
T A
TA
Department of Hand Surgery, University Hospital of Umea, Sweden.
Sunzel
B
B
Holm
S
S
Elmros
T
T
Hallmans
G
G
Sjöberg
S
S
D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D015034:Zinc Oxide / Q000494:pharmacology*
D015034:Zinc Oxide