title: [Peripheral T-cell lymphoma associated with hemophagocytic syndrome: a recently identified entity. Clinico-pathologic and immunohistochemical study of 2 cases].
abstract: The authors report on two examples of peripheral T-cell lymphoma associated with hemophagocytic syndrome. The latter represents a recently described entity, which is characterized by pancytopenia, hepatosplenomegaly, fever and rapid downhill clinical course. Microscopic examination of different tissue samples shows bone-marrow, liver and spleen infiltration by small-medium sized lymphoid elements, which display peripheral T-cell phenotype and are associated with an exuberant hyperplasia of hemophagocytosing, benign-looking histiocytes. The clinical and pathological findings, along with the main differential diagnoses, are discussed.
authors.affiliation: Servizio di anatomia e istologia patologica, Ospedale Morgagni-Pierantoni di Forlì.
authors.forename: A
authors.initials: A
authors.lastname: Saragoni
authors.forename: B
authors.initials: B
authors.lastname: Falini
authors.forename: L
authors.initials: L
authors.lastname: Medri
authors.forename: M
authors.initials: M
authors.lastname: Gaudio
authors.forename: R
authors.initials: R
authors.lastname: Brizio
authors.forename: S
authors.initials: S
authors.lastname: Poggi
authors.forename: E
authors.initials: E
authors.lastname: Sabattini
authors.forename: S
authors.initials: S
authors.lastname: Pileri
mesh_terms: D004912:Erythrocytes; D005260:Female; D015614:Histiocytosis / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013577:Syndrome
vernacular_title: Linfoma a cellule T periferiche con associata sindrome emofagocitica: un'entità di recente identificazione. Studio clinico-patologico ed immunoistochimico di due casi.