Pulmonary infiltrates associated with sulindac therapy.
Pulmonary infiltrates, cough, dyspnea, and fever developed in a 62-year-old woman with chronic degenerative arthritis who had been receiving sulindac therapy for six months. Her pulmonary signs and symptoms resolved upon withholding the drug. Inadvertent rechallenge resulted in rapid recurrence of respiratory symptoms and pulmonary infiltrates. This constellation of clinical findings provides strong evidence of isolated pulmonary reactions as a complication of sulindac therapy.
Takimoto
C H
CH
Department of Medicine, University of California, San Francisco 94143.
Lynch
D
D
Stulbarg
M S
MS
D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008875:Middle Aged; D011859:Radiography; D013467:Sulindac / Q000009:adverse effects*
D013467:Sulindac