Effect of food on absorption of lomefloxacin.
Twelve subjects participated in an open-label, single-dose, balanced three-way crossover study in which the absorptions of lomefloxacin were compared following (i) an overnight fast, (ii) a carbohydrate meal, and (iii) a high-fat meal. The time to peak concentration of lomefloxacin was delayed, but peak concentration in plasma and amount of drug absorbed were unchanged following both meals.
Hooper
W D
WD
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Herston, Australia.
Dickinson
R G
RG
Eadie
M J
MJ
D042462:4-Quinolones; D000042:Absorption; D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D005260:Female; D024841:Fluoroquinolones; D005502:Food; D006801:Humans; D008297:Male; D015363:Quinolones; D013997:Time Factors
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin