[Effects of neferine on heart electromechanical activity in anaesthetized cats].
Neferine, an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action. Neferine 1-10 mg/kg iv dose-dependently decreased the monophasic action potential amplitude (MAPA), prolonged the monophasic action potential duration (MAPD). It also decreased LVP, dP/dt, prolonged SCL, and reduced arterial blood pressure in a dose-dependent manner. These effects were similar to those of quinidine, and different from tetrandrine. The latter had an inhibitory effect on LVP and dP/dt, but had no influence on MAPA and MAPD. The results indicate that neferine and quinidine have similar effects on heart electro-mechanical activity.
Li
G R
GR
Department of Pharmacology, Tongit Medical University, Hankou, China.
Qian
J Q
JQ
Lü
F H
FH
D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D044182:Benzylisoquinolines; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011802:Quinidine / Q000494:pharmacology
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; C057222:neferine; C009438:tetrandrine; D011802:Quinidine