Pathologic characteristics of human T-cell lymphotropic virus (HTLV)-related extranodal orofacial lymphomas.
Eleven cases of extranodal orofacial lymphomas (EOFL), consisting of four HTLV-related and seven HTLV-unrelated EOFL, were investigated with respect to the immunohistochemical and clinical features. HTLV-related EOFL were of T-cell phenotype and were associated with a poorer prognosis than HTLV-unrelated EOFL, most of which were of B-cell origin. The appearance of giant cells with cerebriform nuclei was helpful in identifying HTLV-related EOFL. The relatively high incidence of T-cell type EOFL in our series was considered to be related to the high percentage of HTLV carriers in our district, an area endemic for adult T-cell leukemia-lymphoma.
Kurihara
K
K
Department of Pathology, Uwajima City Hospital, Japan.
Kohno
H
H
Miyamoto
N
N
Chikamori
Y
Y
Kondo
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D005153:Facial Neoplasms / Q000473:pathology*; D005260:Female; D015490:HTLV-I Infections / Q000473:pathology*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology