The effect of gentamicin on the corneal endothelium. An experimental study.
Gentamicin sulfate with preservatives was injected into the anterior chamber of a rabbit eye to evaluate its effect on the corneal endothelium. Endothelial toxicity was evaluated by contact specular microscopy and transmission electron microscopy 48 h after injection. The results suggest that doses ranging from 100 to 400 micrograms of gentamicin are not toxic to the corneal endothelium. Endothelial toxicity occurred when 1,000 micrograms of gentamicin was injected.
Petroutsos
G
G
Laboratoire d'Ophthalmologie, Unite INSERM 86, Paris, France.
Savoldelli
M
M
Pouliquen
Y
Y
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000648:ultrastructure; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D007267:Injections; D011817:Rabbits
D005839:Gentamicins