[A method for developing a controlled process. Development and execution of a program supplying culture medium components for rifamycin B biosynthesis].
The study provided data on the rate of consumption of the main nutrients by the rifamycin-producing culture in relation to their content in the initial medium. A program for feeding ammonium sulfate and cornsteep liquor and joint control of both the nutrients was developed and tested. The results of the testing confirmed the practicable precision of the feeding. The control of cornsteep liquor and ammonium sulfate concentrations with the program allowed to increase the yield of rifamycin B by 15 and 20%, respectively. The joint control increased the level of the required product by 25%.
Kuz'mina
L M
LM
Krasnova
T P
TP
Lysko
A V
AV
Vostrikova
V N
VN
Bushueva
O A
OA
Mal'tsev
N I
NI
D000645:Ammonium Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D001431:Bacteriological Techniques; D003470:Culture Media; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D007218:Industrial Microbiology / Q000379:methods*; D009615:Nocardia / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D012294:Rifamycins / Q000096:biosynthesis*; D013268:Stimulation, Chemical; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology; D014586:USSR; D003313:Zea mays
D003470:Culture Media; D010936:Plant Extracts; D012294:Rifamycins; D013395:Sucrose; C033974:rifamycin B; D005947:Glucose; D000645:Ammonium Sulfate
Metod razrabotki upravliaemogo protsessa. Raschet i realizatsiia programmy podpitok komponentami sredy pri biosinteze rifamitsina B.