Influences of the cholecystokinin analog ceruletide on human sleep and evoked potentials.
Two experiments are reported, investigating the effects of the cholecystokinin analog ceruletide on central nervous activation in man. In experiment I, 0.55 micrograms/h ceruletide was infused at a constant rate during the night to study its effects on spontaneous EEG activity during sleep. In experiment II, we examined the effects of a bolus injection of ceruletide (0.5 micrograms) on components of the auditory evoked potential reflecting exogenously provoked central nervous arousal. While ceruletide had no effect on sleep, it attenuated stimulus-induced cortical arousal.
Pietrowsky
R
R
Angewandte Physiologie, Innere Medizin I, Universität Ulm, BRD.
Fehm
H L
HL
Er
A
A
Bathelt
B
B
Born
J
J
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D002108:Ceruletide; D006854:Hydrocortisone