HIV infection in hemophiliac children: clinical manifestations and therapy.
The effects of human immunodeficiency virus (HIV) disease, with its progressive and multifaceted manifestations, have not yet been fully expressed in the hemophilic population. However, even at this phase of the disease, the effects of the viral illness on the growing hemophilic child are extremely complex and have only recently been recognized and studied. The management of these unfortunate children is difficult and demands understanding and insight to obtain maximum benefit from the limited therapeutic armamentarium at hand. This unsatisfactory situation will continue at least for the near future, requiring innovative research and meticulous medical care in order to help those affected. This review addresses current knowledge pertaining to hemophilic children infected with HIV-1 and covers information available on the epidemiology, clinical manifestations, and management of HIV and its complications.
Gomperts
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Hematology/Oncology, Children's Hospital, Los Angeles, California 90054.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D002648:Child; D006130:Growth Disorders / Q000209:etiology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D015497:HIV-1; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D065227:Transfusion Reaction