Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use.
We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.
Cunniff
C
C
Department of Pediatrics, University of California, San Diego.
Jones
K L
KL
Phillipson
J
J
Benirschke
K
K
Short
S
S
Wujek
J
J
D000653:Amniotic Fluid / Q000187:drug effects / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D002544:Cerebral Infarction / Q000139:chemically induced; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007678:Kidney Glomerulus / Q000002:abnormalities; D007684:Kidney Tubules / Q000002:abnormalities* / Q000473:pathology; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D004656:Enalapril