Phase structures and transitions in fully hydrated diacyltrehalose.
Real time X-ray diffraction was used to examine the gel bilayer to disordered bilayer phase transition in fully hydrated dipalmitoyltrehalose. The L beta to L alpha phase transition was shown to proceed via a second-order thermodynamic process involving incommensurate mesophase bilayer repeat structures and the formation of an intermediate rectangular acyl chain packing subcell. This phenomenon has only been previously shown to occur for dihexadecylphosphatidylcholine (DHPC) and dipalmitoylphosphatidylcholine (DPPC) dihydrates undergoing stepwise (i.e., noncontinuous) temperature changes. It can thus be inferred that the presence of trehalose-trehalose intra-bilayer interactions is a sufficient condition to modify the acyl chain structural rearrangements within the bilayer as a function of temperature.
Lis
L J
LJ
Division of Oncology/Hematology, Chicago Medical School, IL.
Tamura-Lis
W
W
Lim
T K
TK
Quinn
P J
PJ
D015060:1,2-Dipalmitoylphosphatidylcholine; D002236:Carbohydrate Conformation; D004187:Disaccharides; D008051:Lipid Bilayers; D008968:Molecular Conformation; D010742:Phospholipid Ethers; D014199:Trehalose / Q000031:analogs & derivatives; D014961:X-Ray Diffraction
C052298:1,2-dihexadecyl-sn-glycero-3-phosphocholine; D004187:Disaccharides; D008051:Lipid Bilayers; D010742:Phospholipid Ethers; D015060:1,2-Dipalmitoylphosphatidylcholine; C018403:trehalose 6,6'-dipalmitate; D014199:Trehalose