title: [Progress in the diagnosis and therapy of C cell carcinoma of the thyroid gland].
abstract: Between 1986 and 1989 172 patients were operated on thyroid cancer. Twenty-nine (17%) of them had a medullary carcinoma. In 20 of these patients (69%) the carcinoma occurred in a sporadic and in 9 (31%) patients in a familial form. Eighteen patients (62%) had to be operated because of tumor recurrence and in 4 of them additional surgery was necessary because of distant metastases. Due to tumor recurrence 7 patients underwent multiple operations during the above period. Adequate first operation was performed only in 6 patients (33%). Based on family screening a carcinoma was diagnosed in 4 patients in its occult stage. Diagnostic methods include biochemical and imaging methods. Calcitonin is the most sensitive tumor marker. Basal and stimulated serum calcitonin analysis provides a very efficient method to detect medullary carcinoma in early tumor stage and to treat the disease curatively. DNA-analysis improves early diagnosis of persons at risk.
authors.affiliation: Abteilung für Allgemeine und Unfallchirurgie, Heinrich-Heine-Universität, Düsseldorf.
authors.forename: A
authors.initials: A
authors.lastname: Frilling
authors.forename: P E
authors.initials: PE
authors.lastname: Goretzki
authors.forename: H D
authors.initials: HD
authors.lastname: Röher
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy; D014408:Biomarkers, Tumor; D002118:Calcium; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis* / Q000628:therapy*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D010418:Pentagastrin; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010418:Pentagastrin; D002118:Calcium
vernacular_title: Fortschritte in der Diagnostik und Therapie des C-Zell-Karzinoms der Schilddrüse.