title: Polymorphous ventricular tachycardia as undesirable effect of the association of quinidine treatment with hysteresis ventricular inhibited pacing.
abstract: Holter monitoring in a 75-year-old man with a VVI pacemaker with rate hysteresis and concomitant quinidine treatment documented the occurrence of several episodes of non-sustained polymorphous ventricular tachycardia, triggered by each first paced beat following the longer escape interval. These arrhythmias disappeared when quinidine was withdrawn or when the pacemaker was reprogrammed without hysteresis. We hypothesize that the association of the different effects produced by hysteresis and quinidine created the electrophysiologic substrate for the observed arrhythmias.
authors.affiliation: Istituto di Cardiologia, University of Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Della Bella
authors.forename: C
authors.initials: C
authors.lastname: Tondo
authors.forename: G
authors.initials: G
authors.lastname: Marenzi
authors.forename: S
authors.initials: S
authors.lastname: Grazi
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects*; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D006801:Humans; D008297:Male; D011802:Quinidine / Q000009:adverse effects*; D013610:Tachycardia / Q000209:etiology*
chemical_list: D011802:Quinidine