title: Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.
abstract: The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: T
authors.initials: T
authors.lastname: Kodama
authors.forename: M
authors.initials: M
authors.lastname: Freeman
authors.forename: L
authors.initials: L
authors.lastname: Rohrer
authors.forename: J
authors.initials: J
authors.lastname: Zabrecky
authors.forename: P
authors.initials: P
authors.lastname: Matsudaira
authors.forename: M
authors.initials: M
authors.lastname: Krieger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002460:Cell Line; D003001:Cloning, Molecular; D003094:Collagen; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D008077:Lipoproteins, LDL / Q000378:metabolism; D046911:Macromolecular Substances; D008264:Macrophages / Q000032:analysis*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011971:Receptors, Immunologic / Q000235:genetics; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
chemical_list: D008077:Lipoproteins, LDL; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; C032629:acetyl-LDL; D003094:Collagen; D004247:DNA