title: [Severe liver involvement by Capillaria hepatica].
abstract: Human hepatic capillariasis is a rare disease, which predominantly affects children aged 1 to 4 years and has a poor prognosis in extensive infections. This is the first case observed in Germany. The main symptoms are those of severe parasitosis: persistent high fever, hepatomegaly, and excessive hypereosinophilia. Diagnosis is confirmed by the finding of intracellular typical eggs in liver biopsy. There is a lack of established therapy; our 18 months old girl developed liver fibrosis. She survived under a prolonged treatment with high doses of Thiabendazole and two single doses of Ivermectine. Decortin was given to inhibit further granulomatous processes in the liver.
authors.affiliation: Kinderklinik und Kinderpoliklinik, Universität Würzburg.
authors.forename: J
authors.initials: J
authors.lastname: Pannenbecker
authors.forename: T C
authors.initials: TC
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Jeschke
mesh_terms: D000818:Animals; D002195:Capillaria / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007559:Ivermectin / Q000008:administration & dosage; D008099:Liver / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009349:Nematode Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013827:Thiabendazole / Q000008:administration & dosage
chemical_list: D007559:Ivermectin; D013827:Thiabendazole
vernacular_title: Schwerer Leberbefall durch Capillaria hepatica.