Cocaine and the cardiovascular system.
Cocaine abuse is widespread and increasing in North America. One in every four Americans has used cocaine for its euphorogenic properties. The cardiovascular actions of cocaine are similar to those observed following intense sympathetic stimulation. Cocaine increases heart rate, blood pressure and myocardial oxygen demand. Yet, paradoxically it decreases oxygen supply by inducing coronary vasoconstriction, leading to myocardial ischemia. This myocardial ischemia undoubtedly forms the substrate for most of the cardiovascular complications observed with cocaine use. In this article, the history, clinical pharmacology and complications of cocaine abuse are reviewed.
Das
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Division of Cardiology, University of North Dakota School of Medicine, Fargo.
D002319:Cardiovascular System / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D006801:Humans; D019966:Substance-Related Disorders / Q000628:therapy
D003042:Cocaine