Chronic major aphthous stomatitis: oral treatment with low-dose alpha-interferon.
Two patients with chronic major aphthous stomatitis of at least 3 years duration were treated with single daily oral doses (1,200 IU) of interferon alfa-2 alpha (HuIFN alpha). Both patients responded with complete remission of aphthae within 6 weeks. One patient had no recurrence of the disease during a 6-month observation period. The second patient had a recurrent aphtha approximately 4 weeks after the initial lesion resolved; however, the recurrent lesion was less severe than the patient had historically experienced. Retreatment of the recurrent lesion with HuIFN alpha resulted in complete remission within 1 week, and there were no further recurrences during the 6-month observational period.
Hutchinson
V A
VA
Amarillo Virology Research, TX.
Mok
W L
WL
Angenend
J L
JL
Cummins
J M
JM
Richards
A B
AB
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D013281:Stomatitis, Aphthous / Q000628:therapy*
D007370:Interferon Type I