Progress in targeted therapy against human immunodeficiency virus [corrected].
Acquired immunodeficiency syndrome (AIDS) and its related disorders are caused by a retrovirus termed human immunodeficiency virus (HIV). HIV has nine known genes, and each gene provides a target of opportunity for a therapeutic intervention. Knowledge of the life cycle of this virus has already yielded clinically useful therapies and will likely make a major impact against AIDS in the near future, provided that the principles of controlled trials are followed.
Broder
S
S
Clinical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000235:genetics; D015224:Dideoxynucleosides / Q000494:pharmacology; D005814:Genes, Viral; D006678:HIV / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D006801:Humans; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism; D014779:Virus Replication; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D004279:DNA, Viral; D015224:Dideoxynucleosides; D012367:RNA, Viral; D011948:Receptors, Antigen, T-Cell; D014759:Viral Envelope Proteins; D015215:Zidovudine