New findings explaining the mode of action in prevention of facial clefting and first clinical experience.
Positive clinical results of nonspecific drug prevention in 63 pregnancies at risk, in families with occurrence of cleft lip, alveolus and palate are demonstrated. The model of cleft palate in mice, induced by dexamethasone, was used for the experimental foundation of the method. A significant decrease in the cleft palate incidence, up to 70%, was shown, when the animals were given vitamin B-complex prophylactically, simultaneously and/or therapeutically. Three main possible modes of action supported by experimental results are discussed. The results may be of interest also in respect of other malformation of multifactorial origin.
Schubert
J
J
Clinic of Maxillofacial Surgery, Martin-Luther-Universität Halle-Wittenberg, BRD.
Schmidt
R
R
Raupach
H W
HW
D000818:Animals; D002971:Cleft Lip / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control*; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics / Q000517:prevention & control*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D006801:Humans; D015994:Incidence; D051379:Mice; D010919:Placebos; D011295:Prenatal Care; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000627:therapeutic use*
D010919:Placebos; D014803:Vitamin B Complex; D003907:Dexamethasone