title: Concentrations of cefpodoxime in plasma and tonsillar tissue after a single oral dose of cefpodoxime proxetil.
abstract: Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations of cefpodoxime were assayed by a microbiological method. Tonsillar tissue concentrations after 4 and 7 h were 0.24 and 0.09 mg/kg respectively--being 23% of the plasma concentration. The tonsillar tissue concentration after 12 h was less than 0.06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0.06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis.
authors.affiliation: ENT Department, Hôpital Bichat, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Gehanno
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: F
authors.initials: F
authors.lastname: Ichou
authors.forename: E
authors.initials: E
authors.lastname: Sultan
authors.forename: B
authors.initials: B
authors.lastname: Lenfant
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000378:metabolism*; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000097623:Cefpodoxime; D000097627:Cefpodoxime Proxetil
chemical_list: D015296:Ceftizoxime; D011355:Prodrugs; D000097623:Cefpodoxime; D000097627:Cefpodoxime Proxetil