title: [Cigarette smoking and group I pepsinogen levels. Study in a normal population].
abstract: Several studies have shown an influence of cigarette smoking on serum pepsinogen group I (PGI) levels in duodenal ulcer patients and in control subjects. The elevation of PGI in smokers has just been interpreted as reflecting some degree of smoking-induced inflammation of the gastric mucosa. We have determined fasting serum PGI by radioimmunoassay in 163 healthy subjects investigated by a survey conducted on a sample population of an urban area in the North-East of Italy by means of a random selection based on the public registers of home addresses. The data reported confirmed that PGI levels are increased by smoking in a healthy population. The main contribution of this study consists in demonstrating in a non-selected population an increase of the only parameter up to date claimed to be a possible serological predictive index for ulcer disease.
authors.affiliation: Cattedra di Malattie dell'Apparato Digerente, Università di Padova.
authors.forename: B
authors.initials: B
authors.lastname: Germanà
authors.forename: F
authors.initials: F
authors.lastname: Di Mario
authors.forename: F
authors.initials: F
authors.lastname: Vianello
authors.forename: P
authors.initials: P
authors.lastname: Dotto
authors.forename: D
authors.initials: D
authors.lastname: Faggian
authors.forename: M
authors.initials: M
authors.lastname: Plebani
authors.forename: A
authors.initials: A
authors.lastname: Saggioro
authors.forename: R
authors.initials: R
authors.lastname: Naccarato
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A; D010435:Pepsinogens / Q000097:blood*; D010437:Peptic Ulcer / Q000097:blood / Q000209:etiology; D010446:Peptide Fragments / Q000097:blood*; D011863:Radioimmunoassay; D012307:Risk Factors; D012494:Sampling Studies; D012907:Smoking / Q000097:blood*
chemical_list: D010435:Pepsinogens; D010446:Peptide Fragments; C037980:pepsinogen (1-12); D020116:Pepsinogen A
vernacular_title: Fumo di sigaretta e livelli di pepsinogeno del gruppo Io. Studio in una popolazione normale.