GABA-gated chloride ion influx in brains of epileptic El mice.
GABA-gated chloride ion influx was measured in brain "microsac" preparations of epileptic El mice. There was significantly greater sensitivity to GABA in stimulated El mice (which had 14-18 convulsions induced at weekly intervals) than in unstimulated El mice (which had not experienced convulsions) or ddY mice. GABA-gated chloride ion influx was significantly decreased 20 min after a single convulsion, and returned to the preconvulsion level 60 min after a convulsion. These findings suggest that the functional state of GABA-gated chloride channel in El mice is changed secondarily by single or repeated convulsions.
Ito
M
M
Department of Pediatrics, Shimane Medical University, Izumo, Japan.
Tsuda
H
H
Oguro
K
K
Mutoh
K
K
Shiraishi
H
H
Shirasaka
Y
Y
Mikawa
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism*; D015640:Ion Channel Gating / Q000502:physiology*; D008566:Membranes / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000502:physiology; D010812:Physical Stimulation; D012640:Seizures / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002712:Chlorides; D005680:gamma-Aminobutyric Acid