title: [Assessment of hemostasis in patients with myocardial infarction complicated by deep venous thrombosis].
abstract: The study was carried out of 53 patients with acute myocardial infarction receiving no anticoagulant treatment. Changes were traced in certain indices of the blood clotting system and fibrinolysis in plasma in the first 14 days of the disease, with particular attention given to patients in whom during the hospitalization signs of deep vein thrombosis in the lower extremities appeared or a positive result was obtained of the test with 125I-fibrinogen. In a group of 9 patients with deep vein thrombosis developing during the observation, on the first day of myocardial infarction shortening of the kaolin-cephalin clotting time and considerable rise of the level of fibrinogen-fibrin (FDP) degradation products were noted in serum, and on the 14th day raised fibrinogen level and reduced exogenous fibrinolytic activity of the plasma were noted. Increased level of fibrinogen and FDP and exogenous and endogenous plasma fibrinolytic activity observed on the 7th day of the disease were not related to the development of thrombotic complications. The thrombin clotting time, platelet count, factor X level, protein C concentration and antithrombin III activity in the plasma were not significantly changed during myocardial infarction. The obtained results suggest a limited usefulness of the basic tests of the clotting and fibrinolytic systems for early diagnosis of deep vein thrombosis in acute myocardial infarction.
authors.affiliation: Kliniki Hematologii, AM im. K. Marcinkowskiego w Poznaniu.
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
authors.forename: P
authors.initials: P
authors.lastname: Psuja
authors.forename: M
authors.initials: M
authors.lastname: Zozulińska
authors.forename: Z
authors.initials: Z
authors.lastname: Turowiecka
authors.forename: K
authors.initials: K
authors.lastname: Zawilska
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D013924:Thrombophlebitis / Q000097:blood* / Q000150:complications / Q000175:diagnosis
vernacular_title: Ocena układu hemostazy u chorych na zawał serca powikłany zakrzepica zył głebokich kończyn dolnych.