title: Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia.
abstract: The pathogenesis of eclamptic convulsions is unknown. A review of the world literature indicates considerable controversy regarding the ideal anticonvulsant to prevent or control these convulsions. Parenteral magnesium sulfate is the drug of choice to control eclamptic convulsions in North America, but it is rarely used for this purpose overseas. The efficacy and safety of magnesium sulfate in the treatment of preeclampsia-eclampsia have been well documented during the past 60 years. During the same time period, numerous anticonvulsant drugs have been used overseas; however, the ideal drug is yet to be found. Recently phenytoin has been recommended as an alternative for magnesium sulfate; however, comprehensive data regarding its safety and efficacy are lacking. The evidence in the literature indicates that magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.
authors.forename: B M
authors.initials: BM
authors.lastname: Sibai
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004461:Eclampsia / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D012640:Seizures / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; D008278:Magnesium Sulfate