title: Hypertonic and hypovolemic stimulation of thirst in pigs.
abstract: Young female pigs weighing from 15 to 45 kg were used. Plasma osmolality was slowly raised by an intravenous infusion of 15% NaCl. The behavioral threshold was when the pigs began to drink water, and the rise of osmolality was the stimulus. In 23 measurements on 8 pigs the rise of osmolality to initiate drinking was 10.4 +/- 1.4 mosmol/kg (mean +/- SE). There was also an estimated 3.8 +/- 1.4% rise of blood volume. Control infusions of 0.9% NaCl for 1 h usually resulted in no drinking, and plasma osmolality fell by 6.7 +/- 2.1 mosmol/kg, while blood volume did not change. Hypovolemia was effected using furosemide (1 mg/kg body wt) to cause excretion of nearly isotonic urine. Blood volume changes were estimated from plasma protein and packed cell volume data. In 28 measurements on 6 pigs, drinking occurred when blood volume had decreased by 6.7 +/- 1.8%. During 2-h control periods, blood volume did not change appreciably. Plasma osmolality decreased during both the furosemide treatment (by 3.5 +/- 0.7 mosmol/kg) and the controls (by 4.1 +/- 0.8 mosmol/kg).
authors.affiliation: Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: C R
authors.initials: CR
authors.lastname: Anderson
authors.forename: T R
authors.initials: TR
authors.lastname: Houpt
mesh_terms: D000818:Animals; D001769:Blood / Q000378:metabolism*; D001810:Blood Volume / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine; D012965:Sodium Chloride / Q000494:pharmacology; D013552:Swine; D013894:Thirst / Q000502:physiology*
chemical_list: D012965:Sodium Chloride; D005665:Furosemide; D012964:Sodium; D011188:Potassium