title: FMRF-NH2-like mammalian octapeptide: possible role in opiate dependence and abstinence.
abstract: Yang et al. have isolated from bovine brain an octapeptide, FLFQPQRF-NH2 (F-8-F-NH2), with certain antiopiate properties. Malin et al. previously found that ICV injection of this peptide could precipitate an opiate abstinence syndrome in dependent rats. RIA revealed significantly higher levels of F-8-F-NH2 immunoreactivity in CSF withdrawn from the cisterna magna of morphine-dependent rats as opposed to CSF withdrawn from sham-implanted controls. ICV infusion of IgG from antiserum against F-8-F-NH2 significantly reduced the number of abstinence signs subsequently precipitated by naloxone in morphine-dependent rats.
authors.affiliation: University of Houston-Clear Lake, TX 77058.
authors.forename: D H
authors.initials: DH
authors.lastname: Malin
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: M V
authors.initials: MV
authors.lastname: Hammond
authors.forename: D E
authors.initials: DE
authors.lastname: Fowler
authors.forename: R B
authors.initials: RB
authors.lastname: Rogillio
authors.forename: S L
authors.initials: SL
authors.lastname: Brown
authors.forename: J L
authors.initials: JL
authors.lastname: Sims
authors.forename: B M
authors.initials: BM
authors.lastname: Leecraft
authors.forename: H Y
authors.initials: HY
authors.lastname: Yang
mesh_terms: D000818:Animals; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D009020:Morphine / Q000633:toxicity; D009021:Morphine Dependence / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000276:immunology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000737:chemistry; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control
chemical_list: D007074:Immunoglobulin G; D009842:Oligopeptides; D009270:Naloxone; D009020:Morphine; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide