The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia.
The human metallothionein gene complex on chromosome 16 has been remapped to 16q13 using high-resolution in situ hybridization. The complex is not disrupted by the rearrangement breakpoint on the long arm of chromosome 16 in patients with myelomonocytic leukemia with abnormal eosinophils, as had been previously reported. The locus order on 16q is cen-MT-FRA16B-D16S4-inversion breakpoint-HP-tel.
Sutherland
G R
GR
Cytogenetics Unit, Adelaide Children's Hospital, South Australia.
Baker
E
E
Callen
D F
DF
Garson
O M
OM
West
A K
AK
D015139:Blotting, Southern; D002871:Chromosome Banding; D002885:Chromosomes, Human, Pair 16; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008668:Metallothionein / Q000235:genetics*; D009693:Nucleic Acid Hybridization
D015342:DNA Probes; D004247:DNA; D008668:Metallothionein