Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.
A method for the identification and quantification of hydroxyzine in human fluids by GC/NPD is presented. The method employs acepromazine as the internal standard and requires no derivatization. After a single alkaline extraction in n-heptane isoamylalcohol (98.5:1.5, v/v), analysis is achieved in 7 min. The lower limit of detectability was 0.8 ng/ml in plasma. Capillary gas chromatography mass spectrometry assay was developed for confirmation. Toxicological findings, after a fatality involving hydroxyzine are presented as an application of the procedure.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Godelar
B
B
Mangin
P
P
D000293:Adolescent; D002849:Chromatography, Gas; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006919:Hydroxyzine / Q000032:analysis* / Q000097:blood / Q000652:urine; D015203:Reproducibility of Results; D013405:Suicide
D006919:Hydroxyzine