Development of selective adsorbent for free-hemoglobin.
It is well-known that acute renal failure is often caused by hemolysis. Its possible causes may be free-hemoglobin (F-Hb), stroma freed from destroyed red blood cell, and their combined action. Especially, a great amount of F-Hb is liable to flow out during extracorporeal circulation. The plasma fractionation using a membrane has so far been applied to remove F-Hb (1). The molecular weight of F-Hb of 68,000 which is nearly equal to that of albumin has made it still difficult to separate F-Hb effectively. Recently, we have developed an adsorbent that is capable of selectively removing F-Hb and succeeded in obtaining its high adsorption performance.
Tsuchiya
T
T
Akane-Foundation Tsuchiya Hospital, Japan Medical Supply Co. Ltd., Hiroshima.
Kawanishi
H
H
Sugiyama
M
M
Yoshimoto
F
F
D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D006454:Hemoglobins / Q000302:isolation & purification*; D006461:Hemolysis; D006464:Hemoperfusion / Q000379:methods*; D011817:Rabbits
D001672:Biocompatible Materials; D006454:Hemoglobins