Reduced tracheal growth after reconstruction with pericardium.
Four groups of piglets were used to test the use of pericardium and periosteum as free grafts in the repair of full thickness cervical tracheal defects. Pericardium provided an airtight, rapidly healing graft, but did not give sufficient structural rigidity to prevent narrowing and growth failure at the graft site. Composite grafts of pericardium and periosteum were also unsatisfactory, in that the periosteum failed to produce enough bone to prevent collapse of the graft. Since previous studies have shown that periosteal grafts result in good bone formation when applied alone or as an extramucosal support, it is concluded that the osteogenic potential is dependent on the available blood supply and speed of revascularization. It appears that the presence of pericardium in the composite grafts may have inhibited this property.
Dykes
E H
EH
Department of Surgery, Hospital For Sick Children, Toronto, Ontario, Canada.
Bahoric
A
A
Smith
C
C
Kent
G
G
Filler
R M
RM
D000818:Animals; D006085:Graft Survival; D010496:Pericardium / Q000637:transplantation*; D010521:Periosteum / Q000637:transplantation; D013552:Swine; D014132:Trachea / Q000254:growth & development*; D014135:Tracheal Stenosis / Q000151:congenital / Q000601:surgery*