Trimethoprim resistance in Escherichia coli isolates from a geriatric unit.
The frequency of trimethoprim resistance among Escherichia coli isolates from urine samples collected at Turku City Hospital, Turku, Finland, remained at 40% during 1984 to 1988. The proportion of highly resistant (MIC, greater than or equal to 1,024 micrograms/ml) isolates increased, however, and most of these harbored the type I dihydrofolate reductase gene. Only a few isolates possessed type II or VII genes.
Heikkilä
E
E
Department of Medical Microbiology, Turku University, Finland.
Sundström
L
L
Huovinen
P
P
D000368:Aged; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D005387:Finland; D005500:Follow-Up Studies; D006757:Hospital Units; D006801:Humans; D006824:Hybridization, Genetic / Q000187:drug effects; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014295:Trimethoprim / Q000494:pharmacology; D014296:Trimethoprim Resistance / Q000235:genetics*
D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase