The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5.
The ribonuclease inhibitor from human placenta is a tight-binding inhibitor of alkaline and neutral ribonucleases, including the blood vessel-inducing protein, angiogenin. The location of the inhibitor gene within the human genome has now been determined. Utilizing human-rodent hybrid cell lines, it was found on chromosome 11. The localization was refined to chromosome band 11p15 by in situ hybridization of the ribonuclease inhibitor cDNA to normal metaphase chromosomes. A further refinement was obtained by in situ hybridization of the probe to metaphase chromosomes from RPMI 8402 cells, a line containing a well-characterized translocation t(11;14)(p15;q11) with a chromosome 11 breakpoint between the insulin-like growth factor 2 (IGF2) and Harvey rat sarcoma viral oncogene homolog genes. This analysis has localized the ribonuclease inhibitor gene to chromosome subband 11p15.5, distal to the IGF2 gene.
Weremowicz
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Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Fox
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Morton
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Vallee
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D000818:Animals; D002460:Cell Line; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D005260:Female; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010920:Placenta / Q000201:enzymology*; D010926:Placental Hormones / Q000235:genetics*; D012260:Ribonucleases / Q000037:antagonists & inhibitors*; D014178:Translocation, Genetic
D010926:Placental Hormones; C022052:placental ribonuclease inhibitor; D007335:Insulin-Like Growth Factor II; D012260:Ribonucleases