Antimalarial activity of some 4-alkylamino 2/3 methoxy-4-aminodiphenyl sulphones.
From a series of thirty six 2,3, N-substituted 4,4'-diaminodiphenyl sulphones studied for their suppressive activity in mice against blood induced erythrocytic stage of Plasmodium berghei infection, six sulphones (1-6) showed 100% suppressive and curative activity at an intraperitoneal dose of 1 mg/kg x 4 days. These sulphones have been studied for their suppressive activity in still lower doses ranging from 1.0-0.25 mg/kg i.p. x 4 days and for their curative activity at 1 mg/kg i.p. x 4 days in comparison to DDS as standard drug. The maximum tolerated dose of these compounds and DDS has also been determined. These sulphones have better therapeutic efficacy for their suppressive and curative action than DDS.
Chandra
S
S
Division of Parasitology, Central Drug Research Institute, Lucknow, India.
Raina
R
R
Sen
A B
AB
Saxena
M
M
Saxena
A K
AK
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D003622:Dapsone / Q000031:analogs & derivatives*; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010962:Plasmodium berghei
D000962:Antimalarials; D003622:Dapsone