Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis.
In three pediatric patients with necrotizing lymphadenitis, cytosol aminopeptidase activity (c-AP; EC 3.4.11.1) in serum was markedly increased to 509, 417, and 191 U/L, respectively (normal range 25-60 U/L). Lactate dehydrogenase (LD; EC 1.1.1.27) was also increased, with LD-3 predominating. The increased concentrations of c-AP and LD presumably originated from the destruction of infected, activated lymphocytes, especially T lymphocytes. Necrotizing lymphadenitis is probably caused by a lymphocytotropic virus.
Sugaya
N
N
Department of Pediatrics, Nippon Kokan Hospital, Kanagawa, Japan.
Kanno
T
T
Nirasawa
M
M
Mitamura
K
K
Takeuchi
Y
Y
Osano
M
M
D000626:Aminopeptidases / Q000032:analysis*; D001424:Bacterial Infections / Q000150:complications; D002648:Child; D003600:Cytosol / Q000032:analysis / Q000201:enzymology*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008199:Lymphadenitis / Q000201:enzymology* / Q000209:etiology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000032:analysis / Q000201:enzymology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications; D014777:Virus Diseases / Q000150:complications
D007770:L-Lactate Dehydrogenase; D000626:Aminopeptidases