Comparison of the effects of captopril and enalapril on oxyphenbutazone and ethanol-induced gastric lesions in rats.
We have compared the effect of the converting enzyme inhibitors, captopril and enalapril, on two models of gastric ulcers, viz; ethanol and oxyphenbutazone-induced lesions in rats. Both captopril and enalapril did not affect ethanol-induced lesions. While captopril significantly protected against oxyphenbutazone-induced lesions, enalapril aggravated the lesions. This difference is probably due to the lack of the protective sulfhydryl group in the chemical structure of enalapril.
D'Souza
R S
RS
Department of Pharmacology, Goa Medical College, Bambolin.
Bhounsule
S A
SA
Dhume
V G
VG
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D004656:Enalapril / Q000494:pharmacology*; D000431:Ethanol; D008297:Male; D010113:Oxyphenbutazone; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000431:Ethanol; D004656:Enalapril; D002216:Captopril; D010113:Oxyphenbutazone