Effects of potassium or potassium/magnesium supplementation on potassium content of body tissues and fluids in furosemide-treated rats on magnesium-deficient or magnesium-sufficient diet.
Persistent Mg2+ deficiency may interfere with restoration of normal tissue K+ levels. This study examined: a) the effects of chronic furosemide treatment on K+ of sartorius, aorta and ventricle of rats fed Mg2(+)-deficient (100 ppm) or Mg2(+)-sufficient (400 ppm) diet and deionized water; b) whether normal tissue K+ is restored by oral K+ or K+/Mg2+ supplementation with continued furosemide therapy. Levels of Mg2+ were also measured. Furosemide (20 mg/kg i.p.) decreased K+ in sartorius, aorta and ventricle by 5.5, 4.3 and 19.9 microEq/gm (p less than .05), respectively, in rats fed 100 ppm Mg2+ diet. Furosemide did not alter K+ levels in rats fed 400 ppm Mg2+ diet. K+ supplementation (1 mEq/kg for 7 days) restored K+ to normal in sartorius but the addition of Mg2+ supplementation was necessary to restore K+ levels to normal in ventricle and aorta. These data indicate that furosemide can decrease tissue K+ in rats on a Mg2(+)-deficient diet. This decrease can be reversed during diuretic administration by K+ supplementation in sartorius, or K+ plus Mg2+ supplementation in ventricle and aorta.
Coram
W M
WM
Research Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901.
Kapeghian
J C
JC
Plocinski
A F
AF
Toledo
L M
LM
Douglas
F L
FL
Weiss
G B
GB
D000818:Animals; D004032:Diet; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects; D005665:Furosemide / Q000494:pharmacology*; D006352:Heart Ventricles / Q000032:analysis / Q000187:drug effects; D008274:Magnesium / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D008275:Magnesium Deficiency / Q000097:blood / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000032:analysis / Q000187:drug effects; D009132:Muscles / Q000032:analysis* / Q000187:drug effects; D009206:Myocardium / Q000032:analysis; D011188:Potassium / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D005665:Furosemide; D008274:Magnesium; D011188:Potassium