Cholesteryl ester transfer activity in hamster plasma: increase by fat and cholesterol rich diets.
We investigated the presence of cholesteryl ester transfer activity (CETA) in plasma of hamsters kept on various dietary regimens. In hamsters kept on a regular diet, CETA activity was about 5 units/4 mg protein of d greater than 1.21 g/ml fraction of plasma, as compared to about 35 units present in human d greater than 1.21 g/ml fraction. Addition of 15% margarine or butter alone or together with 2% cholesterol resulted in a 2-3-fold increase in plasma CETA. The increase in plasma CETA was correlated with plasma cholesterol levels (r = 0.78; P less than 0.001) and plasma triacylglycerol levels (r = 0.56, P less than 0.001). Hamsters consuming the cholesterol + butter-supplemented diets had the highest plasma CETA, cholesterol and triacylglycerol levels, while CETA in plasma of rats and mice remained nondetectable even after 4 weeks on the diet. The causal relation between hypercholesterolemia, hypertriglyceridemia and evaluation in CETA in hamsters remains to be elucidated.
Stein
Y
Y
Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.
Dabach
Y
Y
Hollander
G
G
Stein
O
O
D000818:Animals; D002788:Cholesterol Esters / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D006224:Cricetinae; D004041:Dietary Fats / Q000008:administration & dosage*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008647:Mesocricetus; D012044:Regression Analysis
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008074:Lipoproteins