[Effect of Salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis].
In 24 open-chest mongrel dogs, coronary artery critical stenosis were produced by a micrometer constriction on left circumflex coronary artery. It was reduction about 87% in lumen area. CBF, -Vce, -dp/dt max were decreased, T was increased (P less than 0.01). 15 minutes after stenosis, the Salvia miltiorrhiza injection was injected into left atrium. CBF, -dp/dt max, -Vce were increased and T was decreased after the injection of Salvia miltiorrhiza. Moreover, the change of CBF was the earliest. The results proved that the Salvia miltiorrhiza could improve the left ventricular diastolic function in coronary artery stenosis.
Xu
H T
HT
Cardiological Department of the Naval Hospital, Beijing.
Chen
S L
SL
Li
L S
LS
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005260:Female; D008297:Male; D010618:Phenanthrolines / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts; D027561:Salvia miltiorrhiza; D013318:Stroke Volume / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; C028972:dan-shen root extract