title: [Industrial production of monoclonal antibodies].
abstract: Murine monoclonal antibodies (mabs) are produced in either mouse ascites or bioreactors (spinner culture, stirred-tank reactor, airlift reactor, hollow-fiber reactor). Human mabs are produced solely in bioreactors. Encapsulation represents a special technology. Hybridoma cells have to be adapted prior to growth in bioreactors. Of crucial importance is the construction of over-producing cell lines by cell- and gene-technological methods. Manipulated cell lines often produce modified mabs.
authors.affiliation: Boehringer Mannheim GmbH Fakultät für Biologie der Universität, Tübingen, Bundesrepublik Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Baron
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D001702:Biopharmaceutics; D005285:Fermentation; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D051379:Mice
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Industrielle Produktion monoklonaler Antikörper.