Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes.
Rokitamycin (RKM), a 3"-O-propionyl derivative of leucomycin A5, is bactericidal against staphylococci near the minimum inhibitory concentrations. RKM bound to ribosomes before-hand is only slightly displaced by erythromycin or josamycin, or even by RKM itself. The adhesive binding of the RKM-ribosome complex might prove to be the lethal event for susceptible staphylococci.
Endou
K
K
Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences, Japan.
Matsuoka
M
M
Nakajima
Y
Y
D004917:Erythromycin / Q000378:metabolism; D015570:Josamycin / Q000378:metabolism; D015644:Miocamycin / Q000031:analogs & derivatives* / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*
D015644:Miocamycin; D004917:Erythromycin; D015570:Josamycin; C033383:rokitamycin