Estradiol benzoate decreases the blood flow through the tibia of female rats.
Effect of estradiol benzoate (EB, Agofollin Depot Spofa, CSSR, 1 mg s.c. once a week for 4 weeks) on local blood flow through the tibia of intact and oophorectomized (OOX) female rats was studied using the 85Sr-microsphere method. In experiment A, the 85Sr-microsphere uptake and blood flow was increased 4 weeks after OOX and significantly decreased after EB in both the intact and OOX animals. In experiment B (intact female rats), the decrease after EB was confirmed both in microsphere uptake and tibial blood flow (48.8% and 57.1% respectively). No changes in the cardiac output and the marked fall of the uptake of labelled microspheres suggest a local circulatory reaction.
Kapitola
J
J
Laboratory for Endocrinology and Metabolism, Charles University, Prague, Czechoslovakia.
Kubícková
J
J
D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008863:Microspheres; D010052:Ovariectomy; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013326:Strontium Radioisotopes; D013977:Tibia / Q000098:blood supply*
D013326:Strontium Radioisotopes; D004958:Estradiol; C010452:estradiol-17 beta-benzoate