Chromaffin cell grafts to rat cerebral cortex reverse lesion-induced memory deficits.
Adrenal chromaffin cells were isolated from donor adult rats and transplanted to the cerebral cortex of bilaterally nucleus basalis magnocellularis-lesioned rats. Chromaffin cell grafts to lesioned animals completely reversed the spatial memory deficit seen in lesioned alone animals on a T-maze alternation task. Although chromaffin cell grafts have been used previously to reverse motor abnormalities arising from defective nigro-striatal aminergic transmission, the present report is the first evidence that chromaffin cell transplants can reverse deficits in memory function. Grafts also enhanced cortical acetylcholinesterase staining.
Welner
S A
SA
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Que., Canada.
Koty
Z C
ZC
Boksa
P
P
D000313:Adrenal Medulla / Q000166:cytology / Q000637:transplantation*; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000601:surgery; D006651:Histocytochemistry; D008297:Male; D008568:Memory / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior; D016042:Transplantation, Heterotopic