Continuous local intraarterial infusion of antithrombotic agents for epigastric flap transfer in rabbit.
In free tissue transfer, the recipient arteries and veins are often damaged by injury, and their lumens are often narrowed due to thickening of the intima. These factors are considered paramount in the poor success rate of free tissue transfers. In the reported study, the authors examined the effects of continuous intraarterial infusion with heparin and urokinase in experimental epigastric flap transfer. By intraarterial infusion, the drug concentration at the target site could be significantly increased. The viability of an epigastric flap transferred to a recipient site with thickened arterial intima was significantly improved in a rabbit model by a seven-day continuous local intraarterial infusion of heparin at 10 U/kg/hr and urokinase at 100 IU/kg/hr, compared with control or intravenous infusion. Use of an anticoagulant with a fibrinolytic enzyme is considered to be the best choice for a successful outcome in flap transfer.
Maeda
M
M
Department of Orthopaedic Surgery, Omiwa Hospital, Nara, Japan.
Fukui
A
A
Inada
Y
Y
Tamai
S
S
Mizumoto
S
S
D000005:Abdomen / Q000098:blood supply; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D001158:Arteries / Q000473:pathology; D003251:Constriction, Pathologic / Q000473:pathology / Q000503:physiopathology; D006085:Graft Survival; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D007261:Infusions, Intra-Arterial; D008297:Male; D011817:Rabbits; D012039:Regional Blood Flow; D016038:Skin Transplantation / Q000379:methods*; D013524:Surgical Flaps / Q000379:methods*; D013848:Thigh / Q000098:blood supply; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014654:Vascular Patency; D000979:alpha-2-Antiplasmin / Q000032:analysis
D000979:alpha-2-Antiplasmin; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator; D000527:Alprostadil