[Suppressive effect of azelastine on the induction of Df antigen specific IL-2 responsiveness in lymphocytes from patients with bronchial asthma].
Effect of azelastine on the induction of Dermatophagoides farinae (Df)-antigen specific IL-2 responsiveness of the lymphocytes was examined. Azelastine suppressed the induction of IL-2 responsiveness induced by Df antigen in peripheral blood mononuclear cells from patients with bronchial asthma in a dose dependent manner. Azelastine suppressed antigen presenting adherent cells but not non-adherent responder cells (T cell rich fraction). The antigen specific IL-2 responsiveness induced by purified protein derivative (PPD) in healthy adults was also suppressed by this drug, but not by concanavalin A (Con A). These data suggest that Azelastine suppresses the antigen specific lymphocyte reactions, and that these effects are based on the weak suppressive effect on antigen presenting and/or processing pathway.
Todoroki
I
I
Department of Pediatrics, National Defense Medical College.
Yoshizawa
I
I
Kawano
Y
Y
Noma
T
T
D000818:Animals; D000941:Antigens / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology*; D002675:Child, Preschool; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008925:Mites / Q000276:immunology*; D010793:Phthalazines / Q000494:pharmacology*
D000941:Antigens; D007376:Interleukin-2; D010793:Phthalazines; C020976:azelastine