title: Future prospects for the chemotherapy of human trypanosomiasis. 1. Novel approaches to the chemotherapy of trypanosomiasis.
abstract: Chemotherapy of trypanosomiasis and leishmaniasis is far from satisfactory and the discovery of new drugs has been slow. Emphasis on the empirical approach to drug development is now shifting towards a more rational, directed approach, which employs the modern tools of science. This is illustrated with respect to the newly discovered drug target, trypanothione, a unique metabolite which is critical for survival of Trypanosoma and Leishmania and absent from the host.
authors.affiliation: Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Fairlamb
mesh_terms: D000818:Animals; D015195:Drug Design; D005544:Forecasting; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D013095:Spermidine / Q000031:analogs & derivatives / Q000378:metabolism; D014345:Trypanosoma / Q000378:metabolism; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: C044809:trypanothione; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase; D005978:Glutathione; D013095:Spermidine