[Comparative effectiveness and biological equivalency of new nifedipine preparations in patients with exercise-induced stenocardia].
The effectiveness of fenigidin and cordafen was studied in comparison with placebo and corinfar after a single administration during pharmacodynamic investigations with tredmill in 14 patients with stable exertional angina. Blood nifedipine concentrations were also compared. The potency of fenigidin was shown to be weaker than that of corinfar. The effect of cordafen and corinfar did not differ significantly. The mean concentrations of nifedipine in the blood serum after administration of equal doses of cordafen and corinfar did not differ considerably, either. Thus the findings were indicative of the equal potency of the same single doses of cordafen and corinfar and of less marked potency of fenigidin due to lower bioavailability.
Slastnikova
I D
ID
Rumiantsev
D O
DO
Piotrovskiĭ
V K
VK
Metelitsa
V I
VI
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D001682:Biological Availability; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010919:Placebos
D010919:Placebos; D009543:Nifedipine
Sravnitel'naia éffektivnost' i bioékvivalentnost' novykh preparatov nifedipina u bol'nykh stenokardieĭ napriazheniia.