A neuronal nicotinic acetylcholine receptor in crayfish neurons.
In warm-blooded vertebrates, neuronal nicotinic acetylcholine receptors (nAChRs) are distinguished from muscle endplate receptors by their ligand affinities and sensitivity to several toxins. In the crayfish optic lobe, synaptic and acetylcholine (ACh)-elicited responses are blocked by toxins (F-toxin and neosurugatoxin) selective for neuronal nAChRs and are insensitive to the alpha-neurotoxins selective for endplate nAChRs.
Pfeiffer-Linn
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Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251.
Glantz
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RM
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003400:Astacoidea; D005071:Evoked Potentials / Q000187:drug effects; D008027:Light; D008978:Mollusk Venoms / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology*; D009899:Optic Lobe, Nonmammalian / Q000502:physiology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*; D012908:Snails; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D008978:Mollusk Venoms; D009498:Neurotoxins; D011978:Receptors, Nicotinic; C036793:neosurugatoxin; D000109:Acetylcholine