[Continuous intracorporeal glucose measurement using enzyme electrodes].
An enzyme electrode (GOD, Pt-Ag/AgCl) is introduced for amperometric measurement of the intracorporal glucose concentration in the subcutaneous tissue. Changes of the glucose concentration in the peripheral blood (PG) were induced by glucose- respectively insulin-infusion in healthy dogs. PG was compared with values found by out means of a sensor implanted in the necks of the dogs (SG). The regression equation SG = 0.81 PG - 1.39 was calculated by analysing 62 steady state levels. The regression delta SG = 0.83 delta PG + 0.22 submitted for the deviation of the normoglycemic base-level. A sensibility loss of the sensor of about 10% appears after an implantation duration of 7.5 hours in medium. Conclusions for the further development of the sensors follows especially with the in vivo functions (biocompatibility, diminution, sterilisation).
Brunstein
E
E
Zentralinstitut für Diabetes Gerhardt Katsch, Karlsburg.
Abel
P
P
Rebrin
K
K
Fischer
U
U
D000818:Animals; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000032:analysis*; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D012044:Regression Analysis; D012867:Skin / Q000737:chemistry*
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose
Kontinuierliche intrakorporale Glucosemessung mittels Enzymelektrode.