title: Effects of nitroprusside on myocardial blood flow and oxygen consumption in conscious lambs with an aortopulmonary left-to-right shunt.
abstract: We studied the effect of vasodilation on regional myocardial blood flow and oxygen consumption of the left ventricular free wall by infusing 10 micrograms/kg/min sodium nitroprusside into 7-week-old conscious lambs with and without aortopulmonary left-to-right shunts. Resting myocardial oxygen consumption in the 13 shunt lambs was significantly higher than in the nine control lambs (989 +/- 104 [+/- SEM] vs. 432 +/- 41 mumol/min/100 g left ventricle). This was achieved by a significantly higher left ventricular myocardial blood flow (294 +/- 33 vs. 143 +/- 16 ml/min/100 g left ventricle) because the arteriovenous oxygen concentration difference across the left ventricular free wall was similar in shunt and control lambs. Infusion of nitroprusside did not significantly change myocardial oxygen consumption and regional myocardial blood flows at 10 and 50 minutes after the onset of the infusion. This occurred despite a substantial drop in aortic and left atrial pressures and stroke volume, which decreases wall stress as well as external work of the left ventricle. Heart rate, however, increased significantly. We postulate that, during infusion of nitroprusside, the potential decrease in myocardial oxygen consumption due to a decrease in wall stress and external work of the left ventricle is neutralized by the consequences of the increased heart rate. In view of this and because of its hemodynamic effects, we do not consider sodium nitroprusside useful in the treatment of circulatory congestion in patients with left-to-right shunts, normal arterial pressures, and normal systemic blood flows.
authors.affiliation: Department of Pediatrics, University of Groningen, The Netherlands.
authors.forename: G P
authors.initials: GP
authors.lastname: Toorop
authors.forename: R
authors.initials: R
authors.lastname: Hardjowijono
authors.forename: M
authors.initials: M
authors.lastname: Dalinghaus
authors.forename: A M
authors.initials: AM
authors.lastname: Gerding
authors.forename: J H
authors.initials: JH
authors.lastname: Koers
authors.forename: W G
authors.initials: WG
authors.lastname: Zijlstra
authors.forename: J R
authors.initials: JR
authors.lastname: Kuipers
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001011:Aorta / Q000601:surgery; D003326:Coronary Circulation / Q000187:drug effects*; D005292:Ferricyanides / Q000494:pharmacology*; D006330:Heart Defects, Congenital / Q000378:metabolism / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011651:Pulmonary Artery / Q000601:surgery; D012756:Sheep
chemical_list: D005292:Ferricyanides; D009599:Nitroprusside