Treatment of acute colonic pseudoobstruction (Ogilvie's syndrome) with cisapride.
A 73-yr-old white woman admitted with lobar pneumonia and congestive heart failure developed progressive colonic pseudoobstruction (Ogilvie's syndrome) 2 days after admission which was unrelieved by diatrizoate meglumine (Gastrografin, Squibb Canada, Montreal) enema and rectal tube. Cisapride, a new gastrointestinal prokinetic agent, was administered intravenously with full resolution of the syndrome. To the authors' knowledge, this is the first reported case of successful treatment of acute colonic pseudoobstruction with cisapride.
MacColl
C
C
Department of Medicine, University of Calgary, Alberta, Canada.
MacCannell
K L
KL
Baylis
B
B
Lee
S S
SS
D000208:Acute Disease; D000368:Aged; D020117:Cisapride; D003108:Colonic Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D003112:Colonic Pseudo-Obstruction / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D004341:Drug Evaluation; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy*; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D015507:Drugs, Investigational; D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride