title: Plasma renin activity and urine beta 2-microglobulin during and after cardiopulmonary bypass: pulsatile vs non-pulsatile perfusion.
abstract: Fourteen patients with normal preoperative renal function underwent aortocoronary bypass graft using cardiopulmonary bypass (CPB) with pulsatile (P;n = 7) or non pulsatile (NP;n = 7) perfusion. In the two groups prebypass values of plasma renin activity (PRA) and urine beta 2-microglobulin (beta 2-M) were within normal limits. PRA increased significantly during CPB and the first 6 h after CPB only in the non-pulsatile group. In both groups, the urine beta 2-M level increased significantly during and after CPB; however, there was no significant difference in urine beta 2-M levels between the two groups. Also, the amount of beta 2-M excreted in urines per unit of time increased significantly in both groups during and after CPB; there was no significant difference between the two groups.
authors.affiliation: Department of Anaesthesiology and Surgical Intensive Care, University of Liège, Belgium.
authors.forename: J L
authors.initials: JL
authors.lastname: Canivet
authors.forename: R
authors.initials: R
authors.lastname: Larbuisson
authors.forename: P
authors.initials: P
authors.lastname: Damas
authors.forename: F
authors.initials: F
authors.lastname: Blaffart
authors.forename: M
authors.initials: M
authors.lastname: Faymonville
authors.forename: R
authors.initials: R
authors.lastname: Limet
authors.forename: M
authors.initials: M
authors.lastname: Lamy
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D006801:Humans; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D011673:Pulsatile Flow; D012083:Renin / Q000097:blood*; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D001613:beta 2-Microglobulin; D012083:Renin