Long term high dose morphine, ketamine and midazolam infusion in a child with burns.
The metabolism of morphine and ketamine was studied in a 14 month old child with extensive burns, who received infusions of both drugs for more than 30 days. The mean plasma clearance of morphine was 29 ml min-1 kg-1 and the plasma ratios of morphine-6-glucuronide to morphine were similar to those previously reported in children. The mean plasma clearance of ketamine was 32 ml min-1 kg-1 which is greater than that previously reported in older children and adults. There were no complications despite high dose long term therapy with morphine, ketamine and midazolam.
Cederholm
I
I
Department of Anaesthesiology, University Hospital, Linköping, Sweden.
Bengtsson
M
M
Björkman
S
S
Choonara
I
I
Rane
A
A
D002056:Burns / Q000097:blood / Q000378:metabolism*; D002059:Burns, Inhalation / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007649:Ketamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008874:Midazolam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009020:Morphine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
D007649:Ketamine; D009020:Morphine; D008874:Midazolam