title: Stereotactic radiosurgery of angiographically occult vascular malformations: indications and preliminary experience.
abstract: Stereotactic radiosurgery has been shown to treat successfully angiographically demonstrated arteriovenous malformations of the brain. Angiographic obliteration has represented cure and eliminated the risk of future hemorrhage. The role of radiosurgery in the treatment of angiographically occult vascular malformations (AOVMs) has been less well defined. In the initial 32 months of operation of the 201-source cobalt-60 gamma knife at the University of Pittsburgh, 24 patients meeting strict criteria for high-risk AOVMs were treated. Radiosurgery was used conservatively; each patient had sustained two or more hemorrhages and had a magnetic resonance imaging-defined AOVM located in a region of the brain where microsurgical removal was judged to pose an excessive risk. Venous angiomas were excluded by performance of high-resolution subtraction angiography in each patient. Fifteen malformations were in the medulla, pons, and/or mesencephalon, and 5 were located in the thalamus or basal ganglia. Follow-up ranged from 4 to 24 months. Nineteen patients either improved or remained clinically stable and did not hemorrhage again during the follow-up interval. One patient suffered another hemorrhage 7 months after radiosurgery. Five patients experienced temporary worsening of pre-existing neurological deficits that suggested delayed radiation injury. Magnetic resonance imaging demonstrated signal changes and edema surrounding the radiosurgical target. Dose-volume guidelines for avoiding complications were constructed. Our initial experience indicates that stereotactic radiosurgery can be performed safely in patients with small, well-circumscribed AOVMs located in deep, critical, or relatively inaccessible cerebral locations.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh, School of Medicine, Pennsylvania.
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
authors.forename: L D
authors.initials: LD
authors.lastname: Lunsford
authors.forename: R J
authors.initials: RJ
authors.lastname: Coffey
authors.forename: D J
authors.initials: DJ
authors.lastname: Bissonette
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
mesh_terms: D000328:Adult; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D007902:Length of Stay; D008279:Magnetic Resonance Imaging; D008297:Male; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D013238:Stereotaxic Techniques; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes