title: Reye and Reye-like syndromes: results of a pilot study in Peninsular Malaya, 1986.
abstract: A pilot epidemiologic study of all cases of Reye and Reye-like syndromes was undertaken at 8 representative major hospitals in Peninsular Malaya from January 1st to December 31st 1986. The cases were classified as definitive Reye's syndrome, clinical Reye's syndrome and encephalo-hepatopathies. Less than 50% of cases reviewed fulfilled the National Center for Disease Control criteria for clinical Reye's syndrome. Causes of Reye-like syndromes/encephalo-hepatopathies included fulminant hepatitis, Japanese B encephalitis, dengue, septicaemia, and complex febrile fits. It was not possible to differentiate clinical Reye's syndrome from the other encephalo-hepatopathies by either the clinical features (except for jaundice) or biochemical parameters. Liver biopsy is necessary for a definitive diagnosis of Reye's syndrome in Malaysia, because of the high prevalence of Reye-like diseases. The mortality rate in the 2 groups of patients is similar. Ingestion of salicylates was not found to be significantly associated with Reye and Reye-like syndromes in this study.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur.
authors.forename: D
authors.initials: D
authors.lastname: Sinniah
authors.forename: R
authors.initials: R
authors.lastname: Sinniah
authors.forename: Y F
authors.initials: YF
authors.lastname: Yap
authors.forename: M
authors.initials: M
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: George
authors.forename: N L
authors.initials: NL
authors.lastname: Lim
authors.forename: S
authors.initials: S
authors.lastname: Balakrishnan
authors.forename: F
authors.initials: F
authors.lastname: D'Cruz
authors.forename: W
authors.initials: W
authors.lastname: Ariffin
authors.forename: P
authors.initials: P
authors.lastname: Kaur
mesh_terms: D003937:Diagnosis, Differential; D004660:Encephalitis / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012202:Reye Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality