title: The effects of intermittent and continuous intravenous infusion of famotidine on gastric acidity in patients with peptic ulcers.
abstract: The effects of intermittent or continuous intravenous infusion of a daily dose of 40 mg of famotidine on the intragastric pH over a 24-hour period were studied in five patients with gastric ulcers and five with duodenal ulcers. Gastric pH was measured continuously using a pH meter. Famotidine was administered at 12-hour intervals for intermittent infusion or was given by continuous infusion. The mean cumulative percentage of pH readings at 6 to 7 or above with continuous infusion was significantly higher than with intermittent infusion in both gastric and duodenal ulcer patients. Thus, the continuous intravenous infusion of a daily dose of 40 mg of famotidine appears to be more useful for the preservation of a high gastric pH in gastric and duodenal ulcer patients than the intermittent infusion of the same daily dose of famotidine.
authors.affiliation: Department of Surgery, Izunagaoka Hospital, Juntendo University School of Medicine, Shizuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Tsumura
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
mesh_terms: D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000188:drug therapy*; D015738:Famotidine / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D015738:Famotidine