[Changes in radiosensitivity of chromosomes at the presynthetic stage of the mitotic cycle: role of single-stranded segments of DNA].
Formation of single-stranded DNA regions was investigated during the presynthetic stage of human lymphocyte cell cycle. Two peaks of single-stranded region production were found in about the middle and near the end of the G1 stage. Both the peaks appeared some hours earlier in gamma-irradiated cells than in control. Experiments showed that the periods of the peak formation coincided with the terms when time-effect dependence for gamma-induced chromosomal aberrations changed its character. The interpretation of the results supposes existence of inherent for the G1 stage process of genetic material correction.
Kondrashova
T V
TV
Luchnik
N V
NV
D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000235:genetics*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007399:Interphase; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology
D004277:DNA, Single-Stranded; D010835:Phytohemagglutinins
Izmeneniia radiochuvstvitel'nosti khromosom na predsinteticheskoĭ stadii mitoticheskogo tsikla: rol' odnonitevykh uchastkov DNK.