[In vitro drug-resistance decrease of ovarian cancer cells].
A chemosensitivity test for ovarian cancer using tritiated thymidine incorporation assay was carried out. A dose-response relationship was observed for cis-platinum and an 5-fold increase of concentration converted the drug resistant tumor into a drug-sensitive one. Verapamil was found to enhance the cytotoxic effect of vincristine against ovarian cancer cells. It is suggested that combination of vincristine with verapamil may be helpful in treating some vincristine-resistant cases.
Lu
S M
SM
Affiliated Obstetrics and Gynecology Hospital, Zhejiang Medical University, Hangzhou.
D002945:Cisplatin / Q000494:pharmacology*; D003536:Cystadenocarcinoma / Q000473:pathology*; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D014700:Verapamil; D002945:Cisplatin