title: Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives.
abstract: New derivatives of 2-thioxo-4,5-imidazolidinedione (3-6, 10, 11) and 2,4,5-imidazolidinetrione (7, 12) were synthesized by N,N'-acylation of asymmetric thioureas and ureas by oxalyl chloride. The obtained compounds were screened for their central action, mainly anticonvulsant activity.
authors.affiliation: Department of Organic Chemistry, Jagiellonian University, Kraków, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Zankowska-Jasińska
authors.forename: H
authors.initials: H
authors.lastname: Borowiec
authors.forename: J
authors.initials: J
authors.lastname: Golus
authors.forename: A
authors.initials: A
authors.lastname: Kolasa
authors.forename: B
authors.initials: B
authors.lastname: Zaleska
authors.forename: L
authors.initials: L
authors.lastname: Krzywosiński
authors.forename: M
authors.initials: M
authors.lastname: Bogdal
authors.forename: B
authors.initials: B
authors.lastname: Przemyk
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004597:Electroshock; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010830:Physostigmine / Q000037:antagonists & inhibitors; D004856:Postural Balance / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D007093:Imidazoles; D013871:Thiones; D012110:Reserpine; D010830:Physostigmine; D010433:Pentylenetetrazole