Action of dexamethasone in an equine model of acute non-immune inflammation.
In a crossover study in seven New Forest ponies the actions of dexamethasone, at a dose rate of 0.06 mg kg-1 administered intravenously, were compared with those of a placebo treatment. Dexamethasone exerted expected effects on plasma and inflammatory exudate concentrations of cortisol and on blood glucose concentration and circulating leucocyte numbers, but it failed to affect exudate concentrations of the eicosanoids, prostaglandin E2, thromboxane B2, 6-keto-PGF1 alpha and leukotriene B4. These findings do not support the hypothesis that the anti-inflammatory actions of dexamethasone in the horse are mediated by inhibition of phospholipase A2.
Lane
P J
PJ
Sanofi Animal Health Ltd., Watford Hertfordshire.
Lees
P
P
Fink-Gremmels
J
J
D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003907:Dexamethasone / Q000031:analogs & derivatives*; D003908:Dexamethasone Isonicotinate / Q000494:pharmacology / Q000627:therapeutic use*; D015194:Diffusion Chambers, Culture; D015777:Eicosanoids / Q000032:analysis; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D006854:Hydrocortisone / Q000032:analysis; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011506:Proteins / Q000032:analysis; D012881:Skin Temperature; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D015777:Eicosanoids; D011506:Proteins; D003907:Dexamethasone; D003908:Dexamethasone Isonicotinate; D014508:Urea; D002784:Cholesterol; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D006854:Hydrocortisone