Some studies on the preservation of indometacin suspensions intended for ophthalmic use.
Suspensions of indometacin (1% w/v), buffered to pH 5.6, may be satisfactorily preserved by 0.002% w/v phenylmercuric nitrate in the presence of hydroxypropylmethylcellulose (0.5% w/v), despite 90% of the preservative being adsorbed to the indometacin powder. Polyvinyl alcohol (1.4%) could be used as an alternative suspending agent.
Vulovic
N
N
School of Pharmacy, Beograd, Yugoslavia.
Primorac
M
M
Stupar
M
M
Brown
M W
MW
Ford
J L
JL
D000327:Adsorption; D001548:Benzalkonium Compounds / Q000032:analysis; D004344:Drug Incompatibility; D004356:Drug Storage; D004926:Escherichia coli / Q000032:analysis; D065347:Hypromellose Derivatives; D007213:Indomethacin / Q000032:analysis*; D008747:Methylcellulose / Q000031:analogs & derivatives; D009883:Ophthalmic Solutions; D010663:Phenylmercury Compounds; D011142:Polyvinyl Alcohol; D013056:Spectrophotometry, Ultraviolet; D013535:Suspensions
D001548:Benzalkonium Compounds; D009883:Ophthalmic Solutions; D010663:Phenylmercury Compounds; D013535:Suspensions; D065347:Hypromellose Derivatives; D011142:Polyvinyl Alcohol; D008747:Methylcellulose; C008860:phenylmercuric nitrate, basic; D007213:Indomethacin