[Distribution and site of action of inhaled aerosols].
Intrapulmonary distribution of nebulized aerosols and sites of air way dilatation following metered-dose aerosol delivery were studied by radionuclide methods. Aerosols penetrate to more peripheral site in slow inhalation and deposition of aerosols in diseased area was enhanced by release at a high lung volume. Pulmonary deposition of radioaerosols released from spacers was over 50% of activity in the spacer. Predominant site of bronchodilatation (beta-stimulant) was on large airways, though action on small airways was also noted.
Kawakami
K
K
Department of Radiology, Jikei University School of Medicine.
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D012115:Residual Volume; D013990:Tidal Volume
D000336:Aerosols; D001993:Bronchodilator Agents