[Meiotic drive of t-haplotypes: segregation of chromosomes in mice with partial trisomy].
The properties of the t haplotypes, specific mutant states of the proximal region of chromosome 17 in the house mouse keep renewing interest. One such property is increased transmission of the t haplotype from heterozygous t/+ males to their offspring. By means of reciprocal translocation T (16; 17)43H, we have constructed males with tertiary trisomy 17 (+T43/++/RB7+) carrying Robertsonian translocation Rb(16.17)7Bnr. The offspring of these males was viable when sperm of +T43/++ and Rb7+ was used. The segregation patterns in the offspring of t-bearing trisomics were analysed on days 16-18 of embryonic development. It was found that in the case when the t haplotype is on the normal acrocentric (male male ++T43/+t12+/Rb7++), its presence in the gamete +t12+/++T43 does not produce meiotic drive. However, when t6 is on Rb7, meiotic drive was equal to 80%. It is concluded that the presence of a normal homolog and a t-bearing chromosome in sperm does not result in meiotic drive. Possible mechanisms of meiotic drive of the t haplotypes are discussed.
Agul'nik
A I
AI
Agul'nik
S I
SI
Ruvinskiĭ
A O
AO
D000818:Animals; D002875:Chromosomes; D006239:Haplotypes; D008297:Male; D008540:Meiosis; D051379:Mice; D009154:Mutation; D014178:Translocation, Genetic; D014314:Trisomy
Meĭoticheskiĭ draĭv t-gaplotipov: segregatsiia khromosom u mysheĭ s chastichnoĭ trisomieĭ.