title: Determination of disulfoton and its metabolites in the body fluids of a Di-Syston intoxication case.
abstract: Disulfoton and its metabolites, two sulfoxides and two sulfones, in the body fluids of a patient who had ingested Di-Syston were analyzed by FPD-GC and GC/MS. After the chemicals in the extract (Fraction 1) obtained by Extrelut column extraction were analyzed, disulfoton and sulfoxides in Fraction 1 were oxidized into sulfones. The sulfones in the extract (Fraction 2) obtained by Extrelut column extraction were analyzed and the estimated concentrations of metabolite were calculated. The concentrations of disulfoton and the sum of the metabolites in the blood collected on admission were 0.093 nmol/g (25.4 ng/g) and 4.92 nmol/g (corresponding to 1.35 micrograms/g of disulfoton), respectively. These concentrations appear to indicate a severe level of disulfoton intoxication.
authors.affiliation: Department of Legal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yashiki
authors.forename: T
authors.initials: T
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Ohtani
authors.forename: F
authors.initials: F
authors.lastname: Chikasue
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
mesh_terms: D000368:Aged; D002849:Chromatography, Gas; D004222:Disulfoton / Q000032:analysis / Q000506:poisoning*; D008401:Gas Chromatography-Mass Spectrometry; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008297:Male; D011041:Poisoning / Q000175:diagnosis
chemical_list: D004222:Disulfoton