title: Relationship between mitogen receptors in peripheral blood lymphocytes and blastogenic responses to mitogen.
abstract: The relationship between the optimum concentration of mitogen which induces lymphocyte blastogenic response and the receptor occupancy by mitogen was investigated. The receptor occupancies which induced maximal blastogenic activity in equine, bovine and canine peripheral blood lymphocytes (PBL) were 31.1 per cent, 26.5 per cent and 38.4 per cent with phytohaemagglutinin-P, and 48.2 per cent, 17.9 per cent and 24.5 per cent with concanavalin A, respectively. The data clearly show that each animal species had its own optimum concentration of mitogen for stimulation of PBL. Optimum concentration for blastogenesis and number of binding sites of each mitogen had a good correlation with each other for all three species.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Fujinaga
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Otomo
authors.forename: T
authors.initials: T
authors.lastname: Koike
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D002417:Cattle / Q000097:blood* / Q000276:immunology; D004285:Dogs / Q000097:blood* / Q000276:immunology; D006736:Horses / Q000097:blood* / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000502:physiology*; D008934:Mitogens / Q000378:metabolism / Q000494:pharmacology; D011975:Receptors, Mitogen / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D008934:Mitogens; D011975:Receptors, Mitogen