Trisomy 12 in uterine leiomyomas. A new cytogenetic subgroup.
Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.
Nilbert
M
M
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Heim
S
S
Mandahl
N
N
Flodérus
U M
UM
Willén
H
H
Mitelman
F
F
D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics*