Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.
The effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.
Shimizu
H
H
AIDS Research Center, National Institute of Health, Tokyo, Japan.
Tsuchie
H
H
Honma
H
H
Yoshida
K
K
Tsuruoka
T
T
Ushijima
H
H
Kitamura
T
T
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives*; D000998:Antiviral Agents; D002460:Cell Line; D003208:Concanavalin A / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000502:physiology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism
D000998:Antiviral Agents; D015699:HIV Envelope Protein gp120; D037102:Lectins; D009844:Oligosaccharides; D003208:Concanavalin A; D017485:1-Deoxynojirimycin; C067263:N-(3-phenyl-2-propenyl)-1-deoxynojirimycin; D005944:Glucosamine