Influence of flavonoids and lanthanides on kappa-carrageenin rat tail thrombosis.
Rat tail thrombosis (RTT) induced by i.v. injection of kappa-carrageenin was not inhibited by p.o. or i.p. administration of the aglucon of rutin, quercetin, but it was slightly inhibited by rutoside-containing Venoruton. The RTT was significantly inhibited by didymlaevulinate, Helodym 88, whereas samarium-containing Phlogosol gave inconsistent results because of the solvent propylene glycol. The RTT model is suitable to detect substances of the flavonoid and lanthanide types with weak antithrombotic activity.
Bekemeier
H
H
Department of Pharmacology, Martin Luther University, Halle-Wittenberg, FRG.
Gabor
M
M
Hirschelmann
R
R
D000818:Animals; D002351:Carrageenan; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives / Q000494:pharmacology; D008674:Metals, Rare Earth / Q000494:pharmacology*; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013623:Tail / Q000098:blood supply*; D013927:Thrombosis / Q000139:chemically induced* / Q000517:prevention & control; D013997:Time Factors
D005419:Flavonoids; D006896:Hydroxyethylrutoside; D008674:Metals, Rare Earth; C005865:troxerutin; D002351:Carrageenan; D011794:Quercetin