[Tumor-associated macrophages (TAM) in the stroma of squamous cell carcinomas of the ENT area studied using monoclonal antibodies].
Monoclonal antibodies were used to examine the presence and nature of tumor associated macrophages and T-lymphocytes in 26 cases of squamous cell carcinoma of head and neck. The content of macrophages varied according to the differentiation of the carcinoma: high differentiation was evidenced by a labelling index by an index between 13.5% and 23.7%, poor differentiation from 27.4% to 35.8%. T-lymphocytes were found where tumors were inflamed, but there was no significant correlation between tumor differentiation and infiltrating T-lymphocytes. The present results that prognosis decreases with the increasing number of tumor associated macrophages in squamous cell carcinoma.
Bettinger
R
R
Zentrum der Hals-Nasen-Ohrenheilkunde, Johann-Wolfgang-Goethe-Universität Frankfurt am Main.
Knecht
R
R
Lörz
M
M
von Ilberg
C
C
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007958:Leukocyte Count; D008264:Macrophages / Q000276:immunology*; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal
Untersuchungen über tumorassoziierte Makrophagen (TAM) im Stroma von Plattenephitelkarzinomen des HNO-Bereiches mit Hilfe von monoklonalen Antikörpern.