Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
In a model of physical dependence in mice, treatment with cyclopyrrolones such as zopiclone and suriclone (from 4 to 400 mg/kg/day), did not modify the sensitivity of the gamma-aminobutyric acid (GABA) receptor complex to the partial inverse agonist FG 7142 following their withdrawal, whereas sensitivity changes were observed after treatment and withdrawal from some benzodiazepines (e.g. lorazepam, diazepam, flunitrazepam and triazolam). These data suggest that, in contrast to some benzodiazepines, zopiclone and suriclone may not produce physical dependence.
Piot
O
O
Rhône-Poulenc Santé, Centre de Recherches de Vitry-Alfortville, Vitry sur Seine, France.
Betschart
J
J
Stutzmann
J M
JM
Blanchard
J C
JC
D000818:Animals; D053961:Azabicyclo Compounds; D002243:Carbolines; D003292:Convulsants; D003975:Diazepam / Q000633:toxicity*; D004195:Disease Models, Animal; D005445:Flunitrazepam / Q000633:toxicity*; D006993:Hypnotics and Sedatives / Q000633:toxicity*; D008140:Lorazepam / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009287:Naphthyridines; D010879:Piperazines / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013329:Structure-Activity Relationship; D019966:Substance-Related Disorders; D013457:Sulfur Compounds; D014229:Triazolam / Q000633:toxicity*
D053961:Azabicyclo Compounds; D002243:Carbolines; D003292:Convulsants; D006993:Hypnotics and Sedatives; D009287:Naphthyridines; D010879:Piperazines; D013457:Sulfur Compounds; C515050:zopiclone; D014229:Triazolam; C035874:FG 7142; D005445:Flunitrazepam; C037283:suriclone; D008140:Lorazepam; D003975:Diazepam