Effects of hypertonic NaCl solution on microvascular haemodynamics in normo- and hypovolaemia.
The aims of this study were to investigate possible resuscitation effects of a single, 10-min, 350-microliters intravenous infusion of 7.5% NaCl in hamsters in hemorrhagic shock and to compare the effects of such infusion with an identical one of 0.9% NaCl on the hamster cheek pouch microcirculation during normovolaemia and after acute bleeding to a hypotension level of about 40 mmHg. No significant differences could be detected between the effects of either infusion given to normovolaemic normotensive hamsters. In the animals subjected to haemorrhage, upon bleeding, arterioles larger than 40 microns constricted, arterioles smaller than 40 microns dilated and venular diameter did not change, while blood flow decreased in all vessels. The main differences between the infusions after haemorrhage were a significant increase in mean arterial pressure and arteriolar blood flow, venoconstriction and a tendency for the smaller arterioles to remain more dilated and the larger ones more constricted after the hypertonic infusion. Central nervous and/or reflex excitation of the sympathetic nervous system could account for the constriction of venules and larger arterioles, while a direct effect of hyperosmolarity could explain the dilatation of the smaller arterioles. The study can therefore help to explain some of the mechanisms underlying the reported resuscitation effect of 7.5% NaCl infusion in animals during severe haemorrhagic hypovolaemia.
Bouskela
E
E
Department of Physiology and Biophysics, University of Lund, Sweden.
Grampp
W
W
Mellander
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D006470:Hemorrhage / Q000188:drug therapy / Q000503:physiopathology; D006982:Hypertonic Solutions; D007262:Infusions, Intravenous; D007552:Isotonic Solutions; D008833:Microcirculation / Q000187:drug effects*; D012769:Shock / Q000188:drug therapy* / Q000503:physiopathology; D012965:Sodium Chloride / Q000494:pharmacology*; D014690:Venous Pressure / Q000187:drug effects
D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D012965:Sodium Chloride