title: No effect of thioridazine on plasma concentrations of carbamazepine and its active metabolite carbamazepine-10,11-epoxide.
abstract: The effect of an oral treatment with thioridazine (100 or 200 mg daily) on plasma concentrations of carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) was studied in eight epileptic patients stabilized on CBZ therapy. No significant changes in steady-state plasma levels of CBZ and CBZ-E occurred, suggesting that CBZ metabolism is not apparently affected by thioridazine.
authors.affiliation: Institute of Pharmacology, University of Messina, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Spina
authors.forename: A M
authors.initials: AM
authors.lastname: Amendola D'Agostino
authors.forename: M P
authors.initials: MP
authors.lastname: Ioculano
authors.forename: G
authors.initials: G
authors.lastname: Oteri
authors.forename: A
authors.initials: A
authors.lastname: Fazio
authors.forename: F
authors.initials: F
authors.lastname: Pisani
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013881:Thioridazine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D002220:Carbamazepine; D013881:Thioridazine; C012227:carbamazepine epoxide