A clinicopathologic study of primary hepatic carcinoid tumors.
Six cases of primary hepatic carcinoid tumors were studied with combined immunocytochemical and electron microscopic techniques. Positive tumor immunostaining with PHE5, LK2H10, neuron-specific enolase (NSE), serotonin, gastrin, and insulin antibodies was observed. At the ultrastructural level, cytoplasmic dense granules were seen in all the cases tested. This finding supports a putative origin of these carcinoids found in the liver from a pluripotential stem cell. The clinical course and follow-up of these cases suggests that this unusual hepatic neoplasm has a more favorable prognosis than other forms of hepatic cancer.
Andreola
S
S
Department of Pathology and Cytology, Istituto Nazionale Tumori, Milano, Italy.
Lombardi
L
L
Audisio
R A
RA
Mazzaferro
V
V
Koukouras
D
D
Doci
R
R
Gennari
L
L
Makowka
L
L
Starzl
T E
TE
van Thiel
D H
DH
D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged