title: Influence of 1,4-benzoquinone derivatives and azomethines on microtubule formation in vitro and experimental leukemias.
abstract: Using two groups of substances (derivatives of 1,4-benzoquinone and azomethines) it was compared their effect on the microtubule formation in vitro and on experimental leukemias. 9 from the 28 substances tested acted cancerostatically, 4 substances inhibited microtubule assembly. 3 compounds (fluorenoneazomethines) revealed both effects.
authors.affiliation: Academy of Sciences, Central Institute of Microbiology and Experimental Therapy, Jena, GDR.
authors.forename: W
authors.initials: W
authors.lastname: Schulze
authors.forename: W
authors.initials: W
authors.lastname: Gutsche
authors.forename: W
authors.initials: W
authors.lastname: Vater
authors.forename: B
authors.initials: B
authors.lastname: Oertel
authors.forename: K J
authors.initials: KJ
authors.lastname: Böhm
authors.forename: E
authors.initials: E
authors.lastname: Unger
authors.forename: W
authors.initials: W
authors.lastname: Werner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016227:Benzoquinones / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008870:Microtubules / Q000187:drug effects*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D012545:Schiff Bases