title: [Surgical chemoprophylaxis with ceftriaxone].
abstract: Ceftriaxone is a cephalosporin of third generation. It is characterized by a broad spectrum, a long half-life and a good capacity of diffusion in tissue. We have studied 67 patients. Age ratio was 44 years. 25 patients did not receive short term prophylaxis; 42 patients did (2 gr iv of ceftriaxone one hour before the operation). In clean surgery, only patients immunodepressed or malnourished received chemoprophylaxis. Patients who received 2 gr iv of ceftriaxone one hour before incision, received antibiotic therapy only on the appearance of septic complications.
  
  
  RESULTS
  two patients submitted to chemoprophylaxis (4.8%) showed complications (cystitis and bronchial pneumonia). In the control group antibiotic therapy was undertaken only if septic complication appeared. 19 patients (76%) did not showed any complications. 6 patients (24%) showed surgical wound infection, acute pharyngo-tracheitis, cystitis. Finally, wound infections were limited exclusively to the control group. The ratio of respiratory infections was not statistically significant in the two groups; cystitis resulted more frequent in the control group than in the prophylaxis group. Prophylaxis with 2 gr single dose of ceftriaxone intravenously is effective in reducing the influence of infective complications in clean/contaminated surgery and clean risk surgery.
authors.affiliation: Tit. Cattedra di Chirurgia dell'Apparato Digerente, Università di Catania.
authors.forename: V
authors.initials: V
authors.lastname: Cavallaro
authors.forename: V
authors.initials: V
authors.lastname: Catania
authors.forename: R
authors.initials: R
authors.lastname: Bonaccorso
authors.forename: F
authors.initials: F
authors.lastname: Barbarino
authors.forename: F V
authors.initials: FV
authors.lastname: Guardalà
mesh_terms: D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors
chemical_list: D002443:Ceftriaxone
vernacular_title: Chemioprofilassi chirurgica con ceftriaxone.