Biological activity of obiopeptide-1, a synthetic peptide derived from the native immune-regulator obioactin.
Tachyzoites of Toxoplasma gondii were killed in mouse macrophage and human somatic cell monolayers by a novel synthetic peptide (Obiopeptide-1) which is a Glycil-penta-Glutaminate (GpG) derivative of native Obioactin. In view of the worldwide prevalence of this protozoan disease and the lack of effective treatments, Obiopeptide-1 may be a new and unique antimicrobial active substance of non-antibiotic chemotherapeutic agents for intracellular parasites, T. gondii and associated nonspecific hypoimmune responses that occur in infected hosts.
Suzuki
N
N
Department of Veterinary Physiology and Protozoan Immunology, Obihiro University, Hokkaido, Japan.
Sakurai
H
H
Saito
A
A
Igarashi
I
I
Omata
Y
Y
Osaki
H
H
D000276:Adjuvants, Immunologic; D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007136:Immunoglobulins; D008264:Macrophages / Q000382:microbiology; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*; D014122:Toxoplasma / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D007136:Immunoglobulins; D010455:Peptides; C041544:obioactin