Reaction of thiyl radicals with alcohols, ethers and polyunsaturated fatty acids: a possible role of thiyl free radicals in thiol mutagenesis?
Possible reactions of thiyl free radicals in biological environment are reviewed. In particular hydrogen transfer processes from model C-H compounds like alcohols and ethers as well as from polyunsaturated fatty acids to thiyl radicals are described to proceed with reasonably high rate constants (10(3)-10(4) and 10(6)-10(7) M-1 s-1, respectively). Thiyl radicals have thus to be considered as potentially hazardous species especially with respect to DNA damage and lipid peroxidation.
Schöneich
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Hahn-Meitner-Institut Berlin, Bereich S, Abteilung Strahlenchemie, Germany.
Asmus
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KD
D000438:Alcohols / Q000378:metabolism*; D004249:DNA Damage; D004987:Ethers / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005609:Free Radicals; D006859:Hydrogen / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008956:Models, Chemical; D016296:Mutagenesis / Q000187:drug effects*; D013438:Sulfhydryl Compounds / Q000378:metabolism* / Q000633:toxicity*
D000438:Alcohols; D004987:Ethers; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D013438:Sulfhydryl Compounds; D006859:Hydrogen