Fragile X frequency in a mentally retarded population in Brazil.
Seventy-five male and 50 female students from 2 special schools for mildly, moderately retarded, or borderline individuals were screened clinically and cytogenetically in order to estimate the contribution of fragile X [fra(X)] syndrome to the cause of mental retardation in Brazil. We found 6 males (8%) from 4 families and 2 unrelated females (4%) with fra(X) chromosomes. One male and one female were isolated cases. The estimated frequency of Martin-Bell [fra(X)] syndrome among mentally impaired individuals in Brazil was similar to that previously reported in other countries.
Mingroni-Netto
R C
RC
Department of Biology, University of São Paulo, Brazil.
Rosenberg
C
C
Vianna-Morgante
A M
AM
Pavanello
R de C
Rde C
D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D002871:Chromosome Banding; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications*; D005820:Genetic Testing; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D012729:Sex Chromosome Aberrations