[The effects of pirenzepine on regenerating parietal cells].
In this work, we have carried out a stereological and ultrastructural study in order to verify the action of pirenzepine on regenerating parietal cells. We have used a control group and operated or nonoperated groups treated with 1, 5 and 25 mg/kg/day pirenzepine. In operated groups an ulcer was provoked by cauterization with a metallic plate in the gastric fundus. Parietal cells in operated groups showed mitochondria with altered crests, a fine granular matrix and a large number of tubulo-vesicles. The comparative stereological analysis demonstrates a generalized decrease in the mitochondria, canaliculi and lysosomal volume density, and an increase in the tubulo-vesicle volume density. Changes detected in these cellular structures would originate a decrease in the production of HCl [correction of ClH].
Ibáñez Delgado
F
F
Facultad de Biología, Departamento de Biología Celular, Universidad de Sevilla.
Torreblanca López
J
J
López-Campos
J L
JL
Moreno Onorato
F J
FJ
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D010295:Parietal Cells, Gastric / Q000187:drug effects* / Q000648:ultrastructure; D010890:Pirenzepine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects*; D013276:Stomach Ulcer / Q000473:pathology
D010890:Pirenzepine
Efectos de la pirenzepina sobre células parietales en regeneración.