title: The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.
abstract: A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.
authors.affiliation: Department of Crystallography, Birkbeck College, London, UK.
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
authors.forename: R
authors.initials: R
authors.lastname: Lapatto
authors.forename: A F
authors.initials: AF
authors.lastname: Wilderspin
authors.forename: A M
authors.initials: AM
authors.lastname: Hemmings
authors.forename: P M
authors.initials: PM
authors.lastname: Hobart
authors.forename: D E
authors.initials: DE
authors.lastname: Danley
authors.forename: P J
authors.initials: PJ
authors.lastname: Whittle
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D016333:HIV Protease / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010434:Pepsin A / Q000235:genetics; D011480:Protease Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D011487:Protein Conformation
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D016333:HIV Protease; D010434:Pepsin A