Effects of streptozotocin-induced diabetes on xylazine-ketamine anesthesia.
The effects of streptozotocin-induced diabetes and insulin on the duration of xylazine-ketamine anesthesia were studied in rats. The duration of anesthesia was significantly reduced in diabetic group as compared to control group. In contrast, the duration of anesthesia in insulin-treated non-diabetic group was not significantly different from control group. The plasma glucose level in control group was increased significantly during and upon recovery from anesthesia as compared to pre-anesthetic levels. The plasma glucose level in diabetic group was not changed during anesthesia; however, it was reduced significantly upon recovery. The plasma glucose level was significantly reduced in insulin-treated group as compared to pre-anesthetic levels. The reduction in duration of anesthesia in diabetic rats is possibly due to enhanced metabolism xylazine and/or ketamine and is independent of plasma glucose level.
Amouzadeh
H R
HR
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078-0353.
Sangiah
S
S
D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005947:Glucose / Q000502:physiology; D007649:Ketamine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines; D014991:Xylazine
D001786:Blood Glucose; D013843:Thiazines; D014991:Xylazine; D007649:Ketamine; D005947:Glucose