Treatment of refractory orbital pseudotumors with pulsed chemotherapy.
Five patients with orbital pseudotumor refractive to initial therapy are discussed. Three had a destructive granulomatous process associated with a sclerosing component. Two exhibited a predominantly lymphocytic infiltration. Chemotherapy with Prednisone (100 mg/day) and either Cytoxan (100 mg/day) or Chlorambucil (10 mg/day) in 5-day pulses is described. All patients responded clinically to this treatment without unfavorable side effects.
Paris
G L
GL
Department of Ophthalmology, Stanford University Medical Center, CA.
Waltuch
G F
GF
Egbert
P R
PR
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002699:Chlorambucil / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage
D002699:Chlorambucil; D003520:Cyclophosphamide; D011241:Prednisone