[Effect of lipid emulsifiers on the properties of organoperfluorine emulsions].
The preparation and application of a new type of organoperfluorine (OPF) emulsions with lipids serving as emulsifiers, their biological and physicochemical properties are discussed. The first-generation emulsions with the nonionic emulsifier, ethylene and propylene oxide blockpolymer, were found to be complementary active and to affect the system's biological properties. Interactions between OPF and phospholipids are analysed. The compositions of the new type OPF emulsions are given, of which perfluoroctyl bromide and perfluoromethyl adamantine emulsions are shown to be currently of most interest, since they are stable at room temperature and exhibit somewhat superior physicochemical and biological parameters. A conclusion is derived that the developed lipid-based OPF emulsions have good clinical prospects.
Oksinoĭd
O E
OE
Romanova
M Zh
MZh
Afonin
N I
NI
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006842:Hydrocarbons, Brominated; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D010743:Phospholipids / Q000008:administration & dosage* / Q000494:pharmacology
D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D008081:Liposomes; D010743:Phospholipids; C057525:perfluoromethyladamantane; D000218:Adamantane; C003072:perflubron
Vliianie lipidnykh émul'gatorov na svoĭstva émul'siĭ perftor- organicheskikh soedineniĭ.