[Clinical and biochemical parameters of parkinsonism induced by 1-methyl-4-phenyl-1,2,2,6-tetrahydropyridine and its methyl-phenyl and methoxy-phenyl derivatives in C57Bl/6 mice].
Possibility of ortho-, para-, meta-methylphenyl and methoxyphenyl-derivates of MPTP to produce parkinsonism was investigated. Only ortho-methylphenyl- and ortho-methoxyphenyl-derivates of MPTP cause a persistent loss in dopamine content in the brain and produced the clinical symptoms of parkinsonism. All substances produced Parkinsonian-like syndrome gives the symptoms of activation of nervous system during 0.5-1 h after injection and symptoms of depression in following 3 h of observations.
Lermontova
N N
NN
Soliakov
L S
LS
Bachurin
S O
SO
Serkova
T P
TP
Petrova
L N
LN
Dranyĭ
O A
OA
Tkachenko
S E
SE
Kalashnikov
V V
VV
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D015655:1-Methyl-4-phenylpyridinium / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D001921:Brain / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008810:Mice, Inbred C57BL; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D013997:Time Factors
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium
Klinicheskie i biokhimicheskie pokazateli parkinsonizma, vyzvannogo 1-metil-4-fenil-1,2,3,6-tetragidropiridinom i ego metil-fenil- i metoksi-fenil-proizvodnymi u mysheĭ C57Bl/6.