[Effects of intra-partum stress on lipid metabolism. Adaptation of plasma lipid transport systems in neonates].
Intrapartum asphyxia modifies lipoprotein cholesterol distribution with possible repercussions related to membrane structures and its metabolic functions. We have studied plasma lipid profile and plasma lipoproteins cholesterol distribution in cord blood from 115 newborn infants and 72 pregnant women at delivery.


CONCLUSIONS
newborn infants with perinatal asphyxia (n, 48; pHua less than 7.20) have a higher cord blood triglyceridemia and lower plasma HDL-cholesterol, associated to high significant concentrations of atherogenic ratios (CT/HDLc, LDLc/HDLc) than normal newborn infants (n, 67; pHua = 7.20) [TG, 54.81 +/- 2.96 mg/dl vs 45.74 +/- 2.10 mg/dl (p less than 0.005); CT/HDLc, 24.00 +/- 1.30 mg/dl vs 29.62 +/- 1.12 mg/dl (p less than 0.05); LDLc/HDLc, 1.38 +/- 0.10 vs 1.07 +/- 0.06 (p less than 0.01)]. The highest triglycemia and atherogenic ratios in the acidotic newborn infants reveal deep changes in "esterified cholesterol/binding proteins" system, whereon "Apo A1-LCAT-Apo D" molecular complex binding HDL participate. More studies must be done to understand well this phenomenology. Furthermore, at delivery, pregnant women, that their newborn infants suffer an intrapartum hypoxia, had lower lipidemia than those who had newborn infants with intrapartum physiological stress.
Campoy Folgoso
C
C
Departamento de Pediatría, Facultad de Medicina, Universidad de Granada.
Bayés García
R
R
Molina Font
J
J
D000222:Adaptation, Physiological; D001238:Asphyxia Neonatorum / Q000097:blood / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D011247:Pregnancy; D013312:Stress, Physiological / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Influencias del estrés intraparto en el metabolismo de los lípidos. Adaptación de los sistemas de transporte de lípidos plasmáticos en el recién nacido.