title: Antibacterial effect of zinc oxide in vitro.
abstract: Antibacterial activity, zinc concentrations and pH were measured in Müller-Hinton broth containing different amounts of zinc oxide and inoculated with Staphylococcus aureus (10(6) colony forming units/ml). The minimum inhibitory concentrations (MIC) of zinc oxide to different clinical isolates were determined using the Müller-Hinton agar dilution tests. Gram-positive bacteria were most susceptible. Gram-negative aerobic bacteria and streptococci were usually not inhibited even at the highest concentrations used (1024 micrograms/ml), but staphylococci--particularly some isolates of Staphylococcus epidermidis--were sensitive enough to allow determination of their MIC.
authors.affiliation: Department of Hand Surgery, University Hospital of Umea, Sweden.
authors.forename: T A
authors.initials: TA
authors.lastname: Söderberg
authors.forename: B
authors.initials: B
authors.lastname: Sunzel
authors.forename: S
authors.initials: S
authors.lastname: Holm
authors.forename: T
authors.initials: T
authors.lastname: Elmros
authors.forename: G
authors.initials: G
authors.lastname: Hallmans
authors.forename: S
authors.initials: S
authors.lastname: Sjöberg
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D015034:Zinc Oxide / Q000494:pharmacology*
chemical_list: D015034:Zinc Oxide