title: Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol.
abstract: 1. The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the beta-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2. A possible pharmacodynamic interaction between oxazepam and the beta-adrenoceptor antagonists was examined using a simple reaction time test (SRT) and by measurement of postural sway. 3. The kinetics of oxazepam were not affected significantly by propranolol or labetalol, although oxazepam and labetalol share the glucuronidation pathway. 4. The SRT was increased by combination of both beta-adrenoceptor antagonists with oxazepam, with the greatest increase after the coadministration of oxazepam with propranolol. Administration of the beta-adrenoceptor antagonists alone had no significant effect. 5. Postural sway was affected significantly only by the combination of oxazepam and propranolol.
authors.affiliation: Department of Medicine F, Gentofte University Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Sonne
authors.forename: M
authors.initials: M
authors.lastname: Døssing
authors.forename: S
authors.initials: S
authors.lastname: Loft
authors.forename: K L
authors.initials: KL
authors.lastname: Olesen
authors.forename: A
authors.initials: A
authors.lastname: Vollmer-Larsen
authors.forename: M A
authors.initials: MA
authors.lastname: Victor
authors.forename: O
authors.initials: O
authors.lastname: Hamberg
authors.forename: H
authors.initials: H
authors.lastname: Thyssen
mesh_terms: D000328:Adult; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D010076:Oxazepam / Q000493:pharmacokinetics* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
chemical_list: D010076:Oxazepam; D011433:Propranolol; D007741:Labetalol