Morphometry of bladder carcinoma: definition of a new variable.
In this study two measurements of nuclear size, the mean area and the size distribution curve of nuclear area, were used to differentiate between two polar groups: nuclei from non-neoplastic urothelium and nuclei from transitional cell carcinomas of bladder with a poor clinical outcome. Wide separation of these groups is necessary if a measurement is to be used to assess tumour grade where the morphometric differences are intermediate between such polar groupings. Separation between two groups was best achieved using a weighted distribution of nuclear size and this is a means of objective scoring of urothelial tumours.
Sowter
C
C
St Bartholomew's Hospital Medical College, West Smithfield, London, England.
Sowter
G
G
Slavin
G
G
Rosen
D
D
D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D011379:Prognosis; D001743:Urinary Bladder / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000648:ultrastructure