[Effects of cortiphen on human tumor strains transplanted into athymic mice and rats].
The antitumour activity of cortiphen synthesized at the All-Union Cancer Research Centre of the USSR Academy of Medical Sciences was studied on human tumour strains transplanted into nude mice and rats. Cortiphen was found to possess an expressed activity to kidney cancer, cancer of corpus uteri, chorionepithelioma, fibrosarcoma. Two strains of colon adenocarcinoma out of three have displayed an expressed sensitivity to cortiphen, while melanoma and Jewing sarcoma strains proved to be weakly sensitive to the preparation.
Bukharova
I K
IK
Revazova
E S
ES
Moroz
L V
LV
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D051381:Rats; D011923:Rats, Nude; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D004338:Drug Combinations; D009588:Nitrogen Mustard Compounds; C058175:cortifen; D003345:Corticosterone
Deĭstvie kortifena na shtammy opukholeĭ cheloveka, transplantiruemye bestimusnym mysham and krysam.