title: Effect of calcium phosphate coating characteristics on early post-operative bone tissue ingrowth.
abstract: The synthesis of model porous metal-CPC materials, and their use in one-parametric studies of bone tissue ingrowth enhancement were considered. By using the same starting calcium-deficient hydroxyapatite powder, three different coatings, CAP1, CAP2 and CAP3, were obtained of thicknesses 50 +/- 5, 75 +/- 5 and 75 +/- 5 microns, respectively. CAP1 and 2 were either the starting powder mixed in a 3:1 ratio CPC: poly(lactic acid) or the powder by itself. The CAP3 coating was the result of a thermal treatment producing a mixture of oxyhydroxyapatite, alpha- and beta-tricalcium phosphate. Orderly oriented wire mesh porous coated specimens were implanted, along with the same specimens lined with CAP 1, 2 or 3. Subsequently, the total of 156 specimens was retrieved at 2, 4 or 6 wk, and tested mechanically and processed for histomorphometry. The data produced considerable evidence for the CPC-dependent enhancement of bone tissue ingrowth in porous metals immediately after implantation. They prove that the materials processing of CPC coatings influences the resulting biological behaviour substantially. Furthermore, they support the hypothesis that ceramic dissolution is a causative factor on the bone tissue growth enhancement mechanisms.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia 19104.
authors.forename: P
authors.initials: P
authors.lastname: Ducheyne
authors.forename: J
authors.initials: J
authors.lastname: Beight
authors.forename: J
authors.initials: J
authors.lastname: Cuckler
authors.forename: B
authors.initials: B
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Radin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001696:Biomechanical Phenomena; D002130:Calcium Phosphates / Q000494:pharmacology*; D002516:Ceramics; D004285:Dogs; D005269:Femur / Q000601:surgery; D006882:Hydroxyapatites; D008422:Materials Testing; D016348:Osseointegration / Q000187:drug effects*; D011184:Postoperative Period; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous