title: Improvement of continuous arteriovenous hemofiltration (CAVH) and hemofiltration (HF) efficiency by adding hemoperfusion (HP).
abstract: Aiming to improve the efficiency of the blood purification convective methods either with spontaneous (CAVH) or with pump-assisted (HF) extracorporeal circulation we inserted after the hemofilter a cartridge containing 70 g of collodion-coated activated charcoal (CAC) microencapsulated, obtaining so hemofiltration and hemoperfusion in series (HF+HP). The obtained results show that in both methods HP addition gives a negligible increase of urea clearance and a practically null increase of phosphate clearance, whereas creatinine and uric acid clearances increase is remarkable especially, in percentage, with low blood flows (CAVH). In the HF+HP system we have also been studying B2-microglobulin (B2-M) clearance aiming at examining the possibility of increasing the removal of substances with higher molecular weight. We have been finding HP addition increases further on B2-M clearance already high in HF. Therefore we think HP addition to convective methods is an interesting step in the attempt to carry out highly efficient blood purification methods.
authors.affiliation: Nephrology and Dialysis Unit, Ospedale di Bollate.
authors.forename: R
authors.initials: R
authors.lastname: Marangoni
authors.forename: F
authors.initials: F
authors.lastname: Civardi
authors.forename: F
authors.initials: F
authors.lastname: Masi
authors.forename: C
authors.initials: C
authors.lastname: Avanzi
authors.forename: R
authors.initials: R
authors.lastname: Savino
authors.forename: A
authors.initials: A
authors.lastname: Manfredi
authors.forename: R
authors.initials: R
authors.lastname: Cimino
mesh_terms: D003404:Creatinine / Q000097:blood; D005069:Evaluation Studies as Topic; D006440:Hemofiltration / Q000379:methods*; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D014118:Toxins, Biological / Q000097:blood / Q000302:isolation & purification; D014508:Urea / Q000097:blood; D014511:Uremia / Q000097:blood / Q000628:therapy*; D014527:Uric Acid / Q000097:blood; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D014118:Toxins, Biological; D001613:beta 2-Microglobulin; D014527:Uric Acid; D014508:Urea; D003404:Creatinine