title: Heterogeneous delivery of cardioplegic solution in the absence of coronary artery disease.
abstract: The prevention of intraoperative myocardial damage with cardioplegic solution depends in large measure on the completeness of its delivery. We created a model to study the regional flow distribution of cardioplegic solutions in nondiseased, diastolically arrested, maximally vasodilated canine hearts. Global and regional myocardial flows were measured at different perfusion pressures in hearts perfused either with blood cardioplegic solution (n = 8) or oxygenated crystalloid cardioplegic solution (n = 2). As coronary perfusion decreased, flow in all layers fell significantly (p less than 0.001). This fall was most dramatic in the subendocardium (p less than 0.05). With both types of cardioplegic solutions, the relationship between pressure and flow was nonlinear: At low coronary perfusion pressures, a given change in pressure resulted in a smaller change in flow than at higher perfusion pressures. In addition, we found that in all dogs and at all pressures there was profound variability in the delivery of cardioplegic solution to different small regions of the left ventricular free wall. At a perfusion pressure of 40 mm Hg, the extremes of regional flow differed on average by 203%. This heterogeneity increased significantly with decreasing perfusion pressures. At the lowest perfusion pressure measured (20 mm Hg), the extremes of regional flow differed on average by 365%. These findings emphasize the importance of coronary pressure on the delivery of cardioplegic solution. At low perfusion pressures, not only is mean flow reduced, but a greater number of regions receive limited amounts of cardioplegic solution. These observations may explain the patchy nature of subendocardial damage seen with inadequate myocardial protection.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco 94143.
authors.forename: G S
authors.initials: GS
authors.lastname: Aldea
authors.forename: R E
authors.initials: RE
authors.lastname: Austin
authors.forename: A E
authors.initials: AE
authors.lastname: Flynn
authors.forename: D L
authors.initials: DL
authors.lastname: Coggins
authors.forename: W
authors.initials: W
authors.lastname: Husseini
authors.forename: J I
authors.initials: JI
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002314:Cardioplegic Solutions / Q000493:pharmacokinetics*; D003326:Coronary Circulation; D004285:Dogs; D006321:Heart / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D014018:Tissue Distribution
chemical_list: D002314:Cardioplegic Solutions