Dopaminergic pharmacological manipulations in normal humans confirm the specificity of the visual (PERG-VEP) and cognitive (P300) electrophysiological alterations in Parkinson's disease.
Retinal and occipital visual evoked potentials and event-related potentials (P300) have been recorded in normal human subjects before and after the administration of the dopaminergic receptor antagonist, haloperidol, and/or the dopaminergic precursor L-DOPA. The data show that either retinal or occipital visual potentials and P300 are delayed by haloperidol. These findings are consistent with the hypothesis that haloperidol in healthy subjects mimicks the electrophysiological abnormalities observed in Parkinson's disease. On the other hand, L-DOPA does not generally modify these latencies in normals, while it is known to decrease the same parameters in parkinsonian patients. This is in accord with the involvement of a specific mechanism in the recovery observed in parkinsonian patients after L-DOPA therapy. Our data confirm that the alterations of visual and cognitive potentials observed in Parkinson's disease are closely related to the impairment of dopaminergic transmission.
Stanzione
P
P
Clinica Neurologica, II Università di Roma, Italy.
Fattapposta
F
F
Tagliati
M
M
D'Alessio
C
C
Marciani
M G
MG
Foti
A
A
Amabile
G
G
D000161:Acoustic Stimulation; D003071:Cognition / Q000502:physiology*; D004298:Dopamine / Q000008:administration & dosage*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*; D011930:Reaction Time; D012016:Reference Values
D006220:Haloperidol; D004298:Dopamine