[Method of studying the effects of pharmacological substances on work capacity of animals in hypobaric hypoxia].
The method of the study of medical agent influence and biological active substances on duration of small laboratory animals swimming has been worked out excluding the air. For this purpose the animals were placed into altitude chamber, filled with water by 1/3 (one-third) of its volume being in antiorthostatic position on dipping into water. It has been established that at the altitude of 4000 (four thousand) meters high the rat swimming duration became shorter in comparison with their work under normal pressure in 2.5-4 times. Bemitil stimulating work in hypobaric hypoxia depresses it sharply. Bemitil stimulating influence on the rat efficiency did not appear with rising. Antioxidant substance ionol increased efficiency in normal conditions and in hypoxia AKS-85 adaptogenic compound increased swimming in the height duration to a greater degree, mildronat substance for efficiency restoration produced actoprotective influence.
Spasov
A A
AA
Kovalev
G V
GV
Tsibanev
A V
AV
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D001562:Benzimidazoles / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology; D000860:Hypoxia; D008763:Methylhydrazines / Q000494:pharmacology; D051379:Mice; D010807:Physical Endurance / Q000187:drug effects*; D011187:Posture; D013550:Swimming
D000975:Antioxidants; D001562:Benzimidazoles; D002317:Cardiovascular Agents; D008763:Methylhydrazines; D002084:Butylated Hydroxytoluene; C049825:bemethyl; C050147:3-(2,2,2-trimethylhydrazine)propionate; D000661:Amphetamine
Metod izucheniia vliianiia farmakologicheskikh veshchestv na rabotosposobnost' zhivotnykh v usloviiakh gipobaricheskoĭ gipoksii.