[Clinical contribution to the problem of correlations between hereditary angioneurotic edema and pregnancy].
Hereditary angioneurotic edema (HAE) is an autosomal dominant disease caused by a deficiency of a complement regulatory protein, the C1INH.HAE is clinically characterized by recurrent, self-limited attacks of edema involving the extremities, face, upper respiratory tract or gastrointestinal tract. Pregnancy in a woman affected by HAE poses therapeutical problems. In fact, prophylactic treatment with danazole or tranexamic acid is control indicated in a pregnant woman. However HAE shows a favourable course in most cases and the delivery, despite the local trauma, is not usually associated with complications. But the occasional occurrence of local edema and the literature report of a death in postpartum, suggest the administration of purified C1INH prophylactically before the delivery. HAE, per sé, neither alters the evolution of pregnancy nor does foetus harm. The A. report on a 22-years old primigravida affected by HAE. She had no attack during the whole gestation, the delivery and the postpartum. She was given 1000 units of purified C1INH concentrate both four hours before the delivery and 24 hours after it.
Ferlazzo
B
B
Istituto di Patologia Medica e Medicina Mediterranea, Università di Messina.
Barrile
A
A
Bonanno
D
D
Crisafi
A
A
Ferrari
U
U
Quattrocchi
P
P
Sorge
R
R
D000328:Adult; D000799:Angioedema / Q000188:drug therapy / Q000235:genetics*; D000075202:Contraindications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010375:Pedigree; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012008:Recurrence; D014148:Tranexamic Acid
D014148:Tranexamic Acid
Contributo clinico al problema dei rapporti tra edema angioneurotico ereditario e gravidanza.