The correlation of passive avoidance deficit in aged rat with the loss of nucleus basalis choline acetyltransferase-positive neurons.
The present study investigates the effects of ageing on the number of choline acetyltransferase (ChAT)-positive neurons in the nucleus basalis (NB) and the correlation between the number of ChAT-positive neurons and passive avoidance (PA) retention in young (3-month-old) and aged (26-month-old) rats. The results indicate that the number of ChAT-positive neurons is decreased in aged rats and that the degree of loss of NB neurons is related to the degree of PA retention deficit in aged rats.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Miettinen
R
R
Sirviö
J
J
Aaltonen
M
M
Riekkinen
P
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001479:Basal Ganglia / Q000166:cytology / Q000201:enzymology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002795:Choline O-Acetyltransferase