title: Potency of atracurium on masseter and adductor pollicis muscles in children.
abstract: The sensitivity of the masseter to atracurium was measured in ten children aged 3-10 yr undergoing elective surgery, and compared with that of the adductor pollicis. During nitrous oxide-halothane anaesthesia and mechanical ventilation, supramaximal nerve stimulation was applied to the ulnar nerve at the elbow and to the nerve to the masseter, at a point inferior to the zygomatic arch, anterior to the mandibular condyle. Jaw closure was measured by a force displacement transducer system attached to an oral airway and connected to a metal frame fixed to the operating table 10 cm caudad to the chin. Cumulative dose-response curves for atracurium were obtained by the injection of doses followed by an infusion to compensate for elimination. The mean ED50s and ED95s were similar at the masseter and the adductor pollicis. At the masseter, these were 0.150 +/- 0.013, mean +/- SEM, mg.kg-1 and 0.254 +/- 0.021 mg.kg-1, respectively. At the adductor pollicis, corresponding values were 0.145 +/- 0.009 mg.kg-1, and 0.259 +/- 0.016 mg.kg-1. However, this relationship was not constant in every patient, and in some patients the masseter was much more sensitive than the adductor pollicis. The time from injection of the first dose of atracurium to maximum blockade was 2.5 +/- 0.2 min at the masseter and 3.2 +/- 0.2 min at the adductor pollicis (P less than 0.05). It is concluded that when atracurium is administered to paediatric patients, neuromuscular blockade is usually of the same intensity at each muscle but occurs sooner at the masseter than at the adductor pollicis.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, Montreal Children's Hospital, Quebec, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Saddler
authors.forename: J C
authors.initials: JC
authors.lastname: Bevan
authors.forename: M H
authors.initials: MH
authors.lastname: Plumley
authors.forename: F
authors.initials: F
authors.lastname: Donati
authors.forename: D R
authors.initials: DR
authors.lastname: Bevan
mesh_terms: D000769:Anesthesia, Inhalation; D001279:Atracurium / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects* / Q000502:physiology; D008410:Masticatory Muscles / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D013933:Thumb
chemical_list: D001279:Atracurium