Cutaneous extramedullary hematopoiesis with a preponderance of atypical megakaryocytes in myelofibrosis.
Extramedullary hematopoiesis was found in the cutaneous papulonodular eruption of a 72-year-old man with myelofibrosis. This is the first reported case to show a preponderance of atypical megakaryocytes in skin lesions. The patient was also unusual in that he had marked generalized lymphadenopathy. The skin lesions almost disappeared after treatment with hydroxyurea.
Schofield
J K
JK
Department of Dermatology, Watford General Hospital, Hertfordshire, England.
Shun
J L
JL
Cerio
R
R
Grice
K
K
D000368:Aged; D001706:Biopsy; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D055728:Primary Myelofibrosis / Q000503:physiopathology*; D012867:Skin / Q000503:physiopathology
D006918:Hydroxyurea