title: [Clinical effectiveness and safety of Seaprose S in the treatment of complications of puerperal surgical wounds].
abstract: The aim of the study was the assessment of the efficacy and safety of Seaprose S in women out patients from the maternity ward with infiltrated surgical wounds subsequent to vaginal birth or caesarean section. The semialkaline proteolithic enzyme Seaprose S, available in 30 mg tablets was administered at a dosage of 3 tablets a day for a period of 8 days. Thirty-two puerpera with a mean age of 31 years +/- 0.9 SE were admitted to the study with an episiotomic wound in 13 cases and a laparotomic wound consequent on caesarean section in the remaining 19 cases. The clinical situation deriving from the surgical wound resolved on average on the 4th day, in particular the swelling and the congestion of the wound had already diminished in the first days of treatment (p less than 0.01). Safety of Seaprose S was good considering that in no cases were side effects attributable to the treatment observed. In conclusion, from the data obtained in this study one may confirm the validity of Seaprose S in the treatment of laparotomic and episiotomic wounds.
authors.affiliation: I Clinica Ostetrico-Ginecologica, Università degli Studi L. Mangiagalli, Milano.
authors.forename: M
authors.initials: M
authors.lastname: Dindelli
authors.forename: M T
authors.initials: MT
authors.lastname: Potenza
authors.forename: G
authors.initials: G
authors.lastname: Candotti
authors.forename: L
authors.initials: L
authors.lastname: Frigerio
authors.forename: G
authors.initials: G
authors.lastname: Pifarotti
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002585:Cesarean Section; D004341:Drug Evaluation; D004841:Episiotomy; D005260:Female; D006139:Guaiacol / Q000031:analogs & derivatives; D006801:Humans; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*; D012697:Serine Endopeptidases; D013530:Surgical Wound Infection
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C020176:metoxibutropate; D006139:Guaiacol; D010447:Peptide Hydrolases; C022624:Seaprose S; D012697:Serine Endopeptidases; D007052:Ibuprofen
vernacular_title: Efficacia clinica e tollerabilità del Seaprose S nel trattamento delle complicanze delle ferite chirurgiche in puerperio.