title: Menstrual cycle values of tumor marker in healthy women and in patients with non-gynecological tumors.
abstract: The aim of the present study is to investigate whether the values of CA 12-5 which is considered a specific ovarian tumor marker can be used in patients with non-gynecological tumors whose values in menstrual cycle phases were not previously investigated. In order to determine whether a particular phase or a combination of phase are important, CA 12-5 values were determined by radioimmunoassay technique in a limited number of patients belonging to three different age groups. CA 12-5 were found to be unrelated to age. No statistically significant difference in CA 12-5 values was noted between samples obtained from patients with tumor and healthy women on the first and second days of menstruation. In both cases the normal value exceeded 35 U/ml. The mean values was 42 U/ml in healthy women and 49 U/ml in tumor patients. Mean CA 12-5 values determined between the 12th and 14th days on which estrogen hormone is at its highest level, were found to be 23 U/ml in healthy women and 40 U/ml in patients with tumors. These values are statistically significant, while CA 12-5 values determined in samples obtained on the 20th-25th days are within the normal range. Values of the CA 12-5 tumor marker during the estrogenic phase are important in the diagnosis, management and follow-up of cancer. Determination of estrogen hormone levels as an additional parameter may provide a significant correlation.
authors.affiliation: Dept. of Basic Oncology, University of Istanbul.
authors.forename: V
authors.initials: V
authors.lastname: Yasasever
authors.forename: N
authors.initials: N
authors.lastname: Bilge
authors.forename: G
authors.initials: G
authors.lastname: Töre
authors.forename: H
authors.initials: H
authors.lastname: Onat
authors.forename: M
authors.initials: M
authors.lastname: Enginún
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*; D010060:Ovulation / Q000502:physiology; D011446:Prospective Studies; D013964:Thyroid Neoplasms / Q000378:metabolism
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor