[Efficacy of GH-releasing hormone and biosynthetic GH in a group of children with growth hormone deficiency].
Eight GH-deficient children were treated with GHRH (1-44), once daily s.c. for 6-18 months. At the 6th month of therapy, 3 patients showed a catch-up growth ("responders"), while the remaining 5 did not ("non-responders"). In all patients treatment was discontinued after 6-18 months, when its effect on growth rate failed. After a wash out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating.
Biscaldi
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IRCCS Policlinico S. Matteo, Clinica Pediatrica, Università di Pavia.
Fiori
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Moretta
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Valtorta
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D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D013007:Growth Hormone-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone
Efficacia del GH-releasing hormone e del GH-biosintetico in un gruppo di bambini con deficit di ormone della crescita.