Enhancement of haemopoietic recovery in sublethally gamma-irradiated mice by the joint use of indomethacin and cystamine.
The effects of indomethacin and cystamine, administered prior to gamma-irradiation of mice, were investigated. Synergistic enhancement of haemopoietic recovery was observed under the conditions of a joint use of both drugs. The reason for this synergistic action is probably a joint operation of two mechanisms, i.e., the lowering of the radiosensitivity of haemopoietic stem cells by cystamine and the increase of the proliferation of surviving haemopoietic cells by indomethacin.
Kozubík
A
A
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Pospísil
M
M
Netíková
J
J
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003538:Cystamine / Q000494:pharmacology*; D004357:Drug Synergism; D006413:Hematopoietic System / Q000187:drug effects* / Q000528:radiation effects; D007213:Indomethacin / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011837:Radiation-Protective Agents; D013154:Spleen / Q000187:drug effects
D011837:Radiation-Protective Agents; D003538:Cystamine; D007213:Indomethacin