Determination of haloperidol and hydroxy haloperidol in human plasma by high performance liquid chromatography.
A method has been developed for the separation and measurement of haloperidol and hydroxy haloperidol in human plasma through high performance liquid chromatography. The method uses chlorohaloperidol as an internal standard and provides a limit of detection of about 0.7 nmol/l for haloperidol and 0.67 nmol/l for hydroxy haloperidol. HPLC and RIA radioimmunoassay methods are compared.
Pommery
J
J
Laboratoire de Toxicologie, Faculté de Pharmacie, Laguesse, Lille.
Foulon
O
O
Morineau
G
G
Lhermitte
M
M
Levron
J C
JC
Erb
F
F
D002851:Chromatography, High Pressure Liquid; D006220:Haloperidol / Q000031:analogs & derivatives / Q000097:blood*; D006801:Humans; D006900:Hydroxylation; D011863:Radioimmunoassay; D012016:Reference Values
C040693:1-(3-(4-chlorobenzoyl)propyl)-4-hydroxy-4-(4-chlorophenyl)piperidine; D006220:Haloperidol