Protein C deficiency in a black South African family. A case report.
Protein C is a vitamin K-dependent anticoagulant that functions by inhibiting the activity of factors Va and VIIIa. An inherited deficiency of this protein may enhance the risk of thrombosis. The first kindred with levels of protein C that averaged 50% of normal in association with recurrent thrombotic events were described in 1981. A black South African family with an inherited deficiency of this protein is reported.
Chetty
N
N
Department of Haematology, School of Pathology, South African Institute for Medical Research, Johannesburg.
Caplan
B A
BA
Reavis
S C
SC
Dukes
I A
IA
Patel
M
M
D000328:Adult; D044383:Black People; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D020151:Protein C Deficiency; D013019:South Africa