Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys.
3-O-Methyldopa (OMD) is the principal circulating metabolite formed from exogenously administered levodopa. We studied the effect of nitecapone (OR-462), a novel inhibitor of catechol-O-methyltransferase (COMT), on OMD formation in cynomolgus monkeys following intravenous levodopa administration. The drug does not cross the blood-brain barrier, and therefore inhibits only peripheral OMD formation. At a dose of 5 mg/kg, nitecapone reduced the area under the OMD concentration-time curve by 50%. Inhibition of OMD production was maximal at 65% following a dose of 10 mg/kg. A dose of 15 mg/kg produced no further inhibition. The plasma pharmacokinetics of carbidopa, levodopa, and OMD in the monkeys were similar to those in humans. No adverse physiological effects of nitecapone were observed. In single-dose studies, OR-462 is an effective peripheral COMT inhibitor.
Cedarbaum
J M
JM
Department of Neurology and Neuroscience, Cornell University Medical College, Burke Rehabilitation Center, White Plains, New York.
Léger
G
G
Reches
A
A
Guttman
M
M
D000818:Animals; D002230:Carbidopa / Q000493:pharmacokinetics; D002394:Catechol O-Methyltransferase / Q000493:pharmacokinetics / Q000494:pharmacology*; D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols / Q000493:pharmacokinetics / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism / Q000493:pharmacokinetics*; D008252:Macaca fascicularis; D008297:Male; D010422:Pentanones / Q000493:pharmacokinetics / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
D065098:Catechol O-Methyltransferase Inhibitors; D002396:Catechols; D010422:Pentanones; D014443:Tyrosine; D007980:Levodopa; C057364:nitecapone; D002394:Catechol O-Methyltransferase; D002230:Carbidopa; C008404:3-methoxytyrosine