[Vasoactive factors of endothelial origin].
The discovery of powerful vasoactive compounds synthetized by the vascular endothelium has led to the elaboration of new physiopathological concepts. We review the present state of knowledge about the role, potential therapeutic virtues, and physiopathological consequences of the three major endothelial vasoactive factors: 1. Prostacyclin (PG12), a powerful vasodilator, and the most potent known inhibitor of platelet aggregation, derived from arachidonic acid metabolism: 2: Endothelium-derived relaxing factor (EDRF) a powerful vasodilator thought to be a short-acting nitroxide; 3: Endothelin, a 21 amino-acid peptide with potent vasoconstricting properties.
Levesque
H
H
Service de médecine interne, CHU Rouen-Boisguillaume.
Chassagne
P
P
Moore
N
N
Courtois
H
H
D001161:Arteriosclerosis / Q000503:physiopathology; D016232:Endothelins / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D009569:Nitric Oxide / Q000096:biosynthesis*
D016232:Endothelins; D009569:Nitric Oxide; D011464:Epoprostenol
Les facteurs vasoactifs d'origine endothéliale.