Neuropsychiatric manifestations of altered thyroid state.
The authors assessed the mood and cognitive effects of sequential T4, T3, and withdrawal of thyroid hormone replacement on 25 patients who had had thyroidectomies for thyroid cancer. The patients experienced increased sadness and anxiety when they were without medication, but not significant difference in mood was noted between T4 and T3. The patients who experienced increased affective symptoms when not taking medication were more likely to have histories of affective illness or mood lability.
Denicoff
K D
KD
Biological Psychiatry Branch, NIMH, Bethesda, MD 20892.
Joffe
R T
RT
Lakshmanan
M C
MC
Robbins
J
J
Rubinow
D R
DR
D000328:Adult; D000339:Affect / Q000187:drug effects*; D001294:Attitude to Health; D003071:Cognition / Q000187:drug effects*; D003866:Depressive Disorder / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D013965:Thyroidectomy; D013974:Thyroxine / Q000009:adverse effects / Q000494:pharmacology* / Q000502:physiology; D014284:Triiodothyronine / Q000009:adverse effects / Q000494:pharmacology* / Q000502:physiology
D014284:Triiodothyronine; D013974:Thyroxine