Glioma proliferation modulated in vitro by isothermal radiofrequency radiation exposure.
Isothermal (37 +/- 0.2 degrees C) exposure of glioma cells (LN71) for 2 h to 27 or 2450 MHz continuous-wave radiofrequency (RF) radiation in vitro modulated the rates of DNA and RNA synthesis 1, 3, and 5 days after exposure. The alterations indicate effects on cell proliferation and were not caused by RF-induced cell heating. The dose response for either frequency of the radiation was biphasic. Exposure to specific absorption rates (SARs) of 50 W/kg or less stimulated incorporation rates of tritiated thymidine (3H-TdR) and tritiated uridine (3H-UdR), whereas higher SARs suppressed DNA and RNA synthesis. Statistically significant time-dependent alterations were detected for up to 5 days postexposure, suggesting a kinetic cellular response to RF radiation and the possibility of cumulative effects on cell proliferation. General mechanisms of effects are discussed.
Cleary
S F
SF
Department of Physiology and Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0051.
Liu
L M
LM
Merchant
R E
RE
D002455:Cell Division; D002460:Cell Line; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005910:Glioma / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D012334:RNA, Neoplasm / Q000096:biosynthesis; D011846:Radio Waves; D013696:Temperature; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm