[Neuropeptides and regulation of various proto-oncogenes in cultured anterior pituitary cells].
The analysis of the characteristics of a number of proto-oncogenes reveals some similarities with the site of action (plasma membrane receptor, nucleus) or the mechanisms of action (coupling protein of the "G" family, transcriptional activity) of neuropeptides and namely hypophysiotropic hypothalamic neuropeptides. The example illustrated in this review concerns the induction of the early nuclear oncogene c. fos by TRH in a prolactin secreting rat pituitary cell line. TRH regulates both, hormone release and biosynthesis, in this cell line. Kinetic and pharmacological studies suggest that the induction of the proto-oncogene mRNA accumulation is rather associated with the TRH-induced release of the stored hormone than with the increased transcriptional activity of the prolactin gene.
Gourdji
D
D
Groupe de Neuroendocrinologie Cellulaire et Moléculaire, UA CNRS, Collège de France, Paris.
D000818:Animals; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000378:metabolism; D011519:Proto-Oncogenes / Q000235:genetics*; D051381:Rats
D009479:Neuropeptides
Neuropeptides et régulation de certains proto-oncogènes dans les cellules antéhypophysaires en culture.