Propylene glycol enhances anti-inflammatory effects of phenylbutazone.
1. The interference of propylene glycol with anti-inflammatory effects of phenylbutazone was investigated. 2. Inhibitory effect of phenylbutazone on both carrageenin-induced edema and the cotton pellet granuloma was increased when propylene glycol was used as solvent. 3. Propylene glycol given alone inhibited carrageenin-induced edema and pleurisy, as well as granulomatous tissue formation. 4. Some pharmacokinetic parameters of phenylbutazone were also changed by propylene glycol administered simultaneously. 5. These results suggest that propylene glycol probably increases the anti-inflammatory effect of phenylbutazone by summation and by raising the plasma half-life and the distribution volume of phenylbutazone.
Oshiro
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Departamento de Farmacologia, Universidade de São Paulo, Brazil.
Teixeira
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Oga
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D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D008297:Male; D010653:Phenylbutazone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011409:Propylene Glycols; D002351:Carrageenan; D010653:Phenylbutazone