Prenatal diagnosis of chromosomal disorders in Delhi.
Prenatal diagnosis of chromosomal disorders was carried out in 144 samples of amniotic fluid during 1986-1989. The commonest indication was pregnancy in women having a previous child with Down syndrome. Cultures were successful in 104 (72.2%) of 144 cases. Three (2.9%) abnormal karyotypes were detected. Of 53 women who had a previous child with Down syndrome, recurrence of trisomy 21 occur d in one (1.9%); while considering all abnormal karyotypes, there were three recurrences (2.9%).
Verma
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Genetic Unit, All India Institute of Medical Sciences, New Delhi.
Mathew
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Elango
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Khanna
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D000328:Adult; D000649:Amniocentesis / Q000379:methods; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy