Effect of human recombinant interleukin-2 on isolated rabbit femoral artery and porcine coronary artery and vein.
Treatment of cancer patients with disseminating malignancy using human recombinant interleukin-2 (rIL-2) is usually complicated by some adverse effects such as hypotension, an increase in vascular permeability and water retention due to the so-called "capillary leak syndrome". Experiments on isolated vessels were carried out to study whether rIL-2 has some direct and/or endothelium-mediated influence upon smooth muscle tone. RIL-2 produced a slight insignificant increase in tension in both intact (E+) and endothelium-denuded (E-) rabbit femoral artery (RFA) rings which was more pronounced in E-rings. No direct or endothelium-mediated relaxation of RFA smooth muscle was observed. Endothelium-dependent relaxation induced by acetylcholine was not inhibited as well. RIL-2 produced equal relaxation in E+ and E- porcine coronary artery (CA) and coronary vein (CV). The relaxing effect was more pronounced in CA than in CV. The rIL-2-induced inhibitory effect on coronary vessels does not depend on endothelium, and its mechanism is not clear until now.
Vedernikov
Y P
YP
Cardiology Research Center, Academy of Medical Sciences, Moscow, USSR.
Gräser
T
T
Vedernikov
A Y
AY
Tonevitsky
A G
AG
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005263:Femoral Artery / Q000187:drug effects*; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013552:Swine
D007376:Interleukin-2; D011994:Recombinant Proteins; D010656:Phenylephrine; D000109:Acetylcholine