title: [Hepatic lesions in acute cardiovascular failure in necropsy specimens].
abstract: To evaluate quali-quantitatively ischemic liver injury due to acute cardiocirculatory failure (ischemic hepatitis), and its real clinical signification, 200 out of 1165 autopsy records with ACF clinical diagnosis were selected; 33/200 (16.5%) shown centrilobular necrosis without inflammatory component, accompanied or not by midzonal compromise. Grade IV centrilobular necrosis (50-100% involved lobules) was present in 96.9%, with 15.5% associated midzonal pattern, and 21.2% of confluent type; 2 additional cases with isolated midzonal necrosis (5.7%) were seen. Only six patients (3.0% of ACF patients, and 18.2% of those with histological injury) shown overt clinical liver disease, one of them with a fulminant hepatitis picture (0.5% of ACF, and 3.0% of patients with ischemic necrosis). Bilirubin levels were 3.4-10.2 mg%, and aminotransferases rose up to 540 times over their seric superior normal limits. Centrilobular necrosis involved 100% of lobules in all cases.
authors.affiliation: Cátedra de Gastroenterología de Post-grado, Universidad Nacional de la Plata.
authors.forename: A
authors.initials: A
authors.lastname: Jmelnitzky
authors.forename: R
authors.initials: R
authors.lastname: Castelletto
authors.forename: A
authors.initials: A
authors.lastname: Rondina
authors.forename: A
authors.initials: A
authors.lastname: Sidoti
authors.forename: M
authors.initials: M
authors.lastname: Apraiz
authors.forename: J C
authors.initials: JC
authors.lastname: Mincarelli
authors.forename: C
authors.initials: C
authors.lastname: Toledo
authors.forename: M M
authors.initials: MM
authors.lastname: Albuquerque
authors.forename: D
authors.initials: D
authors.lastname: Viñas
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000473:pathology*; D008099:Liver / Q000098:blood supply*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D012189:Retrospective Studies
vernacular_title: Valoración del daño hepático en el fallo agudo cardiocirculatorio en material de necropsias.