Reduced cellular immune reactivity in healthy individuals during the malaria transmission season.
Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.
Theander
T G
TG
Department of Infectious Diseases, State University Hospital, Copenhagen, Denmark.
Hviid
L
L
Abu-Zeid
Y A
YA
Abdulhadi
N H
NH
Saeed
B O
BO
Jakobsen
P H
PH
Reimert
C M
CM
Jepsen
S
S
Bayoumi
R A
RA
Jensen
J B
JB
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008288:Malaria / Q000276:immunology* / Q000469:parasitology / Q000635:transmission*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D010961:Plasmodium / Q000276:immunology* / Q000302:isolation & purification; D015800:Protozoan Proteins / Q000276:immunology; D012621:Seasons; D013397:Sudan; D014373:Tuberculin / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D010835:Phytohemagglutinins; D015800:Protozoan Proteins; D014373:Tuberculin; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum