The effects of cocaine on multivariate locomotor behavior and defecation.
The present study utilized a multifactorial open-field analysis (Digiscan activity) to assess behavioral changes induced by various doses of cocaine known to stimulate locomotion. The measures that were implemented included ambulation, rearing, stereotypic behavior, rotational movements and changes in defecation levels. Thirty-two male Sprague-Dawley rats were habituated to Digiscan-16 Animal Activity Monitors (Omnitech Electronics, Columbus, OH) before being injected with 0.0, 10, 20 or 30 mg/kg cocaine. Rats were kept on a reversed light/dark schedule and tested in the middle of the dark cycle. It was found that cocaine consistently increased activity measures; most prominently affecting the rotational and ambulatory indices. Interestingly, this 'activity print' appeared to be dose-dependent and specific to cocaine. Open-field defecation levels were compared to home-cage levels as an additional behavioral correlate. Defecation decreased under all doses of cocaine as compared to control levels (saline injection). This result is attributed to cocaine's weakly sympathomimetic effect.
Zubrycki
E M
EM
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559.
Giordano
M
M
Sanberg
P R
PR
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003672:Defecation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012931:Social Environment; D013239:Stereotyped Behavior / Q000187:drug effects
D003042:Cocaine