Dissolution of bile duct stones with monooctanoin: in vitro study.
Mono-octanoin (Mo) is the drug of choice in the topical litholytic treatment of residual gallstones following cholecystectomy. Although this drug does not produce significant side effects, it requires a lengthy period of treatment (15-20 days). The purpose of this study was to verify the in vitro efficacy of the mixture Mo + 10% H2O vs pure Mo in human cholesterol stones. The findings indicate that this mixture can reduce dissolution time by 15.8% and increase the dissolution rate by 27.9% vs pure Mo. A further significant reduction (p = 0.0001) in dissolution times can be obtained by constant exchange of the solvent at the surface of the stone (stirring).
Pozzi
C
C
3rd Surgical Clinic, School of Medicine, University of Milan, Italy.
Tritapepe
R
R
Di Padova
C
C
Montorsi
M
M
Cesana
B
B
D001649:Bile Duct Diseases / Q000628:therapy*; D002210:Caprylates; D002769:Cholelithiasis / Q000737:chemistry / Q000628:therapy*; D004987:Ethers; D005989:Glycerides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008738:Methyl Ethers; D012997:Solvents / Q000627:therapeutic use*; D014783:Viscosity
D002210:Caprylates; D004987:Ethers; D005989:Glycerides; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether; C025343:monooctanoin