Synthesis of peptides related to immunoglobulin E (IgE) and the examination of their pharmacological activity.
Five kinds of oligopeptides H-Asp-Ser-Asp-OH (1), H-Asp-Gly-Lys-OH (2), H-Ser-Asp-Gly-Lys-OH (3), H-Asp-Ser-Asp-Gly-Lys-OH (4), and H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) related to immunoglobulin E (IgE) were synthesized by the conventional solution method with the objective of obtaining a new type of antiallergic agent. Their pharmacological activity was examined by measuring the inhibition of the production of IgE and relaxation of the smooth muscle contraction of rabbit aorta. H-Ala-Asp-Ser-Asp-Gly-Lys-OH (5) displayed potent inhibition against the production of IgE antibody (69.6%) and relaxation against the contraction of rabbit aorta.
Noguchi
K
K
Hitachi Chemical Co., Ltd., Ibaraki Research Laboratory, Japan.
Matsuo
K
K
Ohta
N
N
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D007073:Immunoglobulin E / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
D010455:Peptides; D007073:Immunoglobulin E