The cytolysis of human neuroblastoma cells by a natural IgM 'antibody'-complement system in pregnancy serum.
Cell lines from 26 human cancers were studied for cytotoxicity when treated with normal pregnancy serum. Cytotoxicity manifested by cell death and cytolysis, occurred in 4 of 8 neuroblastomas studied: SK-N-SH, NGP, LAN-5, and IMR-32. In NGP and SK-N-SH, evidence is presented showing that the cytotoxicity resulted from the cell-surface binding of a natural IgM 'antibody', which sensitized the neuroblastoma cells to the lytic action of complement (C). This system may be involved in a cytolytic form of spontaneous regression of neuroblastoma.
Bolande
R P
RP
Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Mayer
D C
DC
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003165:Complement System Proteins / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007150:Immunohistochemistry; D009365:Neoplasm Regression, Spontaneous / Q000276:immunology; D009447:Neuroblastoma / Q000276:immunology*; D011247:Pregnancy / Q000097:blood; D014407:Tumor Cells, Cultured
D007075:Immunoglobulin M; D003165:Complement System Proteins