Translocation (1;6)(p12;p23) in ANLL.
We report here a case of acute nonlymphocytic leukemia evolving from a myelodysplastic syndrome which developed in an elderly man who had received radiation therapy for a prior cancer. Cytogenetic analysis revealed the following karyotype: 47,XY, + 8,t(1;6)(p13;p23). The breakpoints in the translocation are in the regions of the NRAS1 and PIM1 oncogenes on chromosomes 1 and 6, respectively. This translocation has not been previously observed in hematological malignancies.
Jacob
A K
AK
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Sreekantaiah
C
C
Baer
M R
MR
Sandberg
A A
AA
D000368:Aged; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy; D014178:Translocation, Genetic