title: [Stereotactic radiosurgery in acoustic neurinomas].
abstract: The records of 57 patients with 61 acoustic neurinomas treated with stereotactic radiosurgery at the Karolinska Hospital, Stockholm, from 1982 through 1984, were reviewed. Adequate radiological and clinical follow-up evaluations were available in these cases. An additional 8 patients were treated during this same period but were not included because of insufficient data. The tumors were evaluated with CT or MRI. Their post-operative follow-up period was 6-66 months (mean 28 months). Decrease of tumor size or no change was considered as a response to radiosurgery. This was found in 54 (88%) of the tumors. Small tumors with a diameter of less than 15 mm responded better (93%) than large ones (85%). Ninety-five percent of unilateral tumors and 74% of tumors associated with neurofibromatosis responded well. Seven tumors had definite radiographic signs of subsequent growth. Four were removed using standard microsurgical techniques and three have so far not required further treatment. Facial and trigeminal nerve function was evaluated in 58 facial surfaces where tumors had been irradiated. Transient facial weakness developed in 9% and facial hypesthesia in 9% of the irradiated cases. The onset of these nerve dysfunctions appeared with a latency period of 4 to 15 months after radiosurgery. Excluding the ears which had been totally deaf before the treatment, forty-one ears were evaluated fully by audiometry prior to and one year after irradiation. 30% of them had no change in hearing, 68% had a more or less pronounced deterioration and 2% had improvement. We regard efficiency in arresting tumor growth without endangering life, preservation of facial nerve function, and only a day of hospitalization as major benefits of radiosurgery.
authors.affiliation: Department of Neurosurgery, Karolinska Hospital Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: G
authors.initials: G
authors.lastname: Norén
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000532:radiotherapy / Q000601:surgery*; D011879:Radiotherapy Dosage; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed