title: 5-Fluorouracil neurotoxicity.
abstract: Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.
authors.affiliation: Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599.
authors.forename: D H
authors.initials: DH
authors.lastname: Moore
authors.forename: W C
authors.initials: WC
authors.lastname: Fowler
authors.forename: L S
authors.initials: LS
authors.lastname: Crumpler
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D013832:Thiamine Deficiency / Q000150:complications; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D005472:Fluorouracil