Biliary elimination of non-steroidal anti-inflammatory drugs in patients.
In view of evidence in animals that enterohepatic recirculation of non-steroidal anti-inflammatory drugs contributes to small intestinal mucosal damage we have investigated the extent of biliary elimination of three nonsteroidals. Ibuprofen (n = 3), diclofenac (n = 2) and indomethacin (n = 3) were given to six patients with a percutaneous transhepatic cholangiodrainage placed in the bile duct system. One patient received all three drugs. The mean biliary elimination of ibuprofen was 0.82% of the given dose compared with 50.41% urinary excretion. When diclofenac or indomethacin was administered 4.62% and 6.40% of the dose were found in bile, whereas 34.73% and 32.22% (means) were recovered from urine, respectively. The mean percentage eliminated in bile as unchanged drug and active phase II metabolites was 0.15% for ibuprofen, 1.09% for diclofenac and 5.02% for indomethacin.
Schneider
H T
HT
Department of Medicine I, University of Erlangen-Nuernberg, FRG.
Nuernberg
B
B
Dietzel
K
K
Brune
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism*; D002779:Cholestasis / Q000378:metabolism; D003137:Common Bile Duct Diseases / Q000378:metabolism; D004008:Diclofenac / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000493:pharmacokinetics; D007213:Indomethacin / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D007052:Ibuprofen; D007213:Indomethacin