H-2 restriction and serotype crossreactivity of anti-reovirus cytotoxic T lymphocytes (CTL).
Murine anti-reovirus cytotoxic T lymphocytes (CTLs) were analyzed for H-2 restricted recognition of virus infected target cells and for potential cross-reactivity with cells infected by reovirus serotype 1 (T1; Lang strain) or by serotype 3 (T3; Dearing strain). Anti-reovirus CTL specifically lysed virus infected cells and lysis was shown to be H-2 restricted by the H-2Dd, H-2Ld, H-2Kd, H-2Kb, and H-2Kk antigens. No H-2 antigens were identified which failed to restrict virus recognition by anti-reovirus CTL. Anti-T1 and anti-T3 CTLs were also shown to crossreact completely with cells infected with the opposite virus serotype. Thus, anti-reovirus CTLs are restricted by a broad spectrum of H-2 antigens and they detect common rather than unique structural components of these two viral serotypes.
Parker
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Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA.
Sears
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DW
D000818:Animals; D002461:Cell Line, Transformed; D002860:Chromium Radioisotopes; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic / Q000235:genetics*; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012087:Reoviridae / Q000276:immunology*
D002860:Chromium Radioisotopes; D006183:H-2 Antigens