[Prospects for realizing a structure of the spiral-turn-spiral type in a "zinc finger"].
The realization of two models for Zn-finger structure--DNA-binding domain was estimated by taking into account the geometric and energetic requirements of polypeptide chain folding. The following structures were taken as models: antiparallel beta-structure and helix-turn-helix motif. The latter hasn't been considered earlier as the possible structure for Zn-finger. The preference was given to the above-mentioned models on the base of the available experimental data. It was shown that the helix-turn-helix motif for which the angle between axes of alpha-helices doesn't exceed 40 degrees cannot be excluded from the list of the assumed models for Zn-finger. There is a suggestion that the helix-turn-helix motif is likely to be characteristic for the majority of DNA-binding domains in proteins.
Vishnepol'skiĭ
B M
BM
Pirtskhalava
M K
MK
D004268:DNA-Binding Proteins / Q000737:chemistry; D008958:Models, Molecular; D011487:Protein Conformation; D013237:Stereoisomerism; D016335:Zinc Fingers
D004268:DNA-Binding Proteins
O vozmozhnosti realizatsii u "tsinkovogo pal'chika" struktury tipa spiral'-izgib-spiral'.