Hepatic drug clearance: the effect of age using indocyanine green as a model compound.
The hepatic extraction ratio and clearance of indocyanine green (ICG) were determined and used to derive apparent liver blood flow in nine subjects between the ages of 22 and 83 years. There was no correlation between the hepatic extraction ratio of ICG and age (rs = -0.435, NS). There was a significant negative correlation between both ICG clearance and age (rs = -0.710, P less than 0.05) and apparent liver blood flow and age (rs = -0.750, P less than 0.05). These results validate the comparison of liver blood flow values derived from ICG clearance in humans over a wide age range and confirm that liver blood flow does fall with age.
Wynne
H A
HA
Geriatric Clinical Pharmacology Unit, University of Newcastle upon Tyne.
Goudevenos
J
J
Rawlins
M D
MD
James
O F
OF
Adams
P C
PC
Woodhouse
K W
KW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012039:Regional Blood Flow; D013056:Spectrophotometry, Ultraviolet
D007208:Indocyanine Green