title: Elective subtotal splenectomy. Indications and results in 33 patients.
abstract: Elective subtotal splenectomy was performed in 33 patients (30 children and 3 adults) between 1981 and 1989. Indications for the procedure were (1) prevention of azathioprine-induced neutropenia (n = 20); (2) Type I Gaucher disease (n = 9); and (3) cholesteryl ester storage disease, chronic myelogenous leukemia, thalassemia major, and splenic cyst in one patient each. There were no operative deaths, no reoperations for bleeding, and 30 of 33 (91%) patients had a functioning splenic remnant documented by a postoperative radionuclide spleen scan. One patient developed neutropenia without evidence of viral infection that required temporary cessation of azathioprine and the patient with thalassemia major had only transient improvement in transfusion requirements. All other patients (94%) had control of the underlying condition for which the operation was performed. We conclude that subtotal splenectomy is a safe, effective therapy for a variety of nontraumatic conditions.
authors.affiliation: Department of Surgery, Children's Hospital National Medical Center, Washington, D.C. 20010.
authors.forename: P C
authors.initials: PC
authors.lastname: Guzzetta
authors.forename: E J
authors.initials: EJ
authors.lastname: Ruley
authors.forename: H F
authors.initials: HF
authors.lastname: Merrick
authors.forename: C
authors.initials: C
authors.lastname: Verderese
authors.forename: N
authors.initials: N
authors.lastname: Barton
mesh_terms: D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005776:Gaucher Disease / Q000601:surgery; D006801:Humans; D007223:Infant; D009503:Neutropenia / Q000139:chemically induced / Q000517:prevention & control; D013154:Spleen / Q000503:physiopathology; D013156:Splenectomy / Q000009:adverse effects / Q000379:methods*; D013163:Splenomegaly / Q000601:surgery
chemical_list: D001379:Azathioprine