title: Evaluation of aspirin, caffeine, and their combination in postoperative oral surgery pain.
abstract: Three hundred fifty outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive a single oral dose of aspirin 650 or 1000 mg, caffeine 65 mg, a combination of aspirin 650 mg with caffeine 65 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. Estimates of summed pain intensity difference, peak pain intensity difference, total relief, peak relief, and hours of 50% relief were derived from these subjective reports. All active treatments except caffeine were significantly superior to placebo. Pairwise comparisons indicated the aspirin-caffeine combination was statistically superior to aspirin 650 mg alone for hours of 50% relief among patients who had severe baseline pain. Adverse effects were transitory and none were serious.
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: J A
authors.initials: JA
authors.lastname: Forbes
authors.forename: K F
authors.initials: KF
authors.lastname: Jones
authors.forename: C J
authors.initials: CJ
authors.lastname: Kehm
authors.forename: W K
authors.initials: WK
authors.lastname: Smith
authors.forename: C M
authors.initials: CM
authors.lastname: Gongloff
authors.forename: J R
authors.initials: JR
authors.lastname: Zeleznock
authors.forename: J W
authors.initials: JW
authors.lastname: Smith
authors.forename: W T
authors.initials: WT
authors.lastname: Beaver
authors.forename: M
authors.initials: M
authors.lastname: Kroesen
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008964:Molar, Third; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction
chemical_list: D002110:Caffeine; D001241:Aspirin