Asymmetric synthesis of a chiral norbornene derivative by lipase-catalyzed transesterification of cis-endo-5-norbornene-2,3-dimethanol and its application to the synthesis of an optically active TXA2 antagonist.
Murata
M
M
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Ikoma
S
S
Achiwa
K
K
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004951:Esterification; D009904:Optical Rotation; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D001643:Bridged Bicyclo Compounds; C067206:2-(acetoxymethyl)-3-(hydroxymethyl)bicyclo-(2.2.1)-hept-5-ene; D013928:Thromboxane A2