[Low T3 syndrome (3,3',5-triiodothyronine) in relation to the extent of surgical trauma].
Thirty patients undergoing extra-thyroid surgery were divided into two groups (A and B) according to the extent of surgical stress (Group A: major surgery; Group B; minor surgery). Thyroid hormone levels were measured before the operation and up to the 3rd postoperative day in Group B and up to the 7th postoperative day in Group A. A low T3 syndrome was observed in all 30 patients examined of the first postoperative day (reduction of T3 and increase in rT3 without alterations of total thyroxin or signs of hypothyroidism) with normalisation of thyroid values by 3rd postoperative in Group B and later in Group A. The persistence of the syndrome in the latter group was due to the extent of surgical stress, the duration of anesthesia, the presence of stress factors such as staying in intensive therapy, painful symptoms and a negative energy balance during the first days following operation. This syndrome is indicative of a physiological adaptation process to reduce O2 consumption, basal metabolism and in particular protein catabolism.
Guberti
A
A
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Ferrara.
Vivarelli
R
R
Tartari
S
S
Marchi
M
M
Verri
M
M
Pavanelli
L
L
Buccoliero
C
C
D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D014284:Triiodothyronine / Q000172:deficiency*
D014284:Triiodothyronine
La sindrome da basso T3 (3,3', 5-triiodotironina) in relazione all'entità del trauma chirurgico.