Refeeding attenuates bombesin-induced hypothermia in the rat.
The tetradecapeptide bombesin is a potent agent in producing hypothermia when injected centrally. Bombesin-induced hypothermia at normal ambient temperature occurs under conditions of food deprivation or insulin-induced hypoglycemia. This experiment examined the effect of refeeding on the duration of bombesin-induced hypothermia. Rats (n = 7) received microinfusions of bombesin (0.1 microgram/1.0 microliter) into the preoptic area under separate conditions of food deprivation (18 h) and insulin pretreatment (10 U/kg, IM). Core body temperature was evaluated over a period of 4 h with or without food available during testing. Hypothermia was observed under all conditions during the first 2 h. Food-deprived and insulin-pretreated rats not permitted access to food remained hypothermic until at least 4 h following bombesin. These results are discussed in terms of the possible role of glucose availability in the production and duration of bombesin-induced hypothermia.
Barton
C
C
Department of Psychology, University of South Alabama, Mobile 36688.
Babcock
A M
AM
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D001839:Bombesin / Q000494:pharmacology*; D004435:Eating / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology*; D007267:Injections; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D011301:Preoptic Area; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D001839:Bombesin