Neurotoxicity induced by the D-1 agonist SKF 38393 following microinjection into rat brain.
Microinjection of the D-1 agonist R-SKF 38393 into rat striatum resulted in extensive neurotoxic damage as revealed by the presence of large lesions upon histological analysis. These lesions were observed following a single injection of the drug into the ventrolateral striatum (30 micrograms/0.5 microliters) or nucleus accumbens (3.0 or 30 micrograms/0.5 microliters). This neurotoxic damage was also observed following microinjection of the inactive isomer S-SKF 38393. The mechanisms underlying these effects are presently unknown. The use of this compound for intracerebral microinjection studies should be re-evaluated. In view of the usefulness of central microinjections in studying the role of D-1 and D-2 receptors in behavior, it is suggested that alternative D-1 agonists, or ways of minimizing the toxicity of SKF 38393, should be considered.
Kelley
A E
AE
Department of Psychology, Harvard University, Cambridge, MA 02138.
Delfs
J M
JM
Chu
B
B
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000633:toxicity*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine