Endogenous colonization by gentamicin-resistant gram-negative bacilli elaborating aminoglycoside (3)-5-acetyltransferase.
Members of the family Enterobacteriaceae that elaborate aminoglycoside 3-5-acetyltransferase [AAC(3)-5] caused a nosocomial outbreak at the Vanderbilt University Medical Center and have persisted. To see whether the gene for AAC(3)-5 was present in the community, stool cultures of newly admitted patients and ambulatory persons were examined with a specific gene probe. AAC(3)-5-positive strains were present in the intestinal flora examined.
Barg
N L
NL
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Cooper
J F
JF
D000123:Acetyltransferases / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D015139:Blotting, Southern; D003428:Cross Infection / Q000382:microbiology / Q000635:transmission; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000201:enzymology / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000635:transmission; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D009693:Nucleic Acid Hybridization; D010957:Plasmids; D011446:Prospective Studies
D001426:Bacterial Proteins; D005839:Gentamicins; D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase