title: [24-hour blood pressure monitoring. Results with captopril once a day].
abstract: In a trial conducted in a physician's office, the adequacy of a single daily dose of the ACE-inhibitor captopril in the management of hypertension was investigated by 24-hour monitoring. Patients of both sexes shown by conventional blood pressure measurements to respond to captopril were included in the study. After a two-week washout period, during which no anti-hypertensive treatment was given, the patients were subjected to 24-hour blood pressure monitoring prior to and following eight weeks of treatment with a daily dose of 50 mg captopril. At the end of the treatment period the mean 24-hour systolic blood pressure decreased from 158 (SD +/- 24) mmHg to 131 (SD +/- 20) mmHg, and the mean 24-hour diastolic blood pressure from 99 (SD +/- 22) mmHg to 84 (SD +/- 14) mmHg. No side effects were observed. These results show that a single daily dose of captopril suffices to reduce blood pressure adequately over 24 hours also under outpatient conditions.
authors.affiliation: Arzt für Innere Medizin, Gehrden.
authors.forename: W H
authors.initials: WH
authors.lastname: Puhlmann
authors.forename: P
authors.initials: P
authors.lastname: Strüder
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D015924:Blood Pressure Monitors; D002216:Captopril / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D002216:Captopril
vernacular_title: 24-Stunden-Blutdruckmonitoring. Ergebnisse unter Captopril einmal täglich.