Inner ear impairment following combined CDDP (platinum preparation) and radiation therapy.
Hearing ability was examined in patients with head and neck cancer treated by combined CDDP and electron beam therapy. In 3 of 7 patients with maxillary cancer, hearing impairment apparently attributable to the therapy was noted on the affected side. In one of these 3 patients, the temporal bone was observed, but the cause of hearing impairment could not be determined. We present patients with cancer of the external ear in whom radiation-caused hearing impairment worsened probably due to combined CDDP and electron beam therapy.
Okamura
H
H
Department of Otolaryngology, Fukushima Medical College, Japan.
Anzai
T
T
Ohtani
I
I
Hoshino
T
T
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D007758:Ear, Inner / Q000187:drug effects; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D011878:Radiotherapy / Q000009:adverse effects*; D013701:Temporal Bone / Q000473:pathology
D009944:Organoplatinum Compounds; C055423:didimethylsulfoxide dichloroplatinum(II)