title: Juvenile chronic myelogenous leukemia with abnormalities of chromosomes 4 and 5.
abstract: A case of a boy with juvenile chronic myelogenous leukemia (CML) and independent clonal abnormalities of chromosomes 4 and 5 is presented. The characteristics and cytogenetics of CML are discussed, as is the involvement of chromosomes 4 and 5 in hematologic malignancies. The significance of these karyotypic findings in juvenile CML is explored.
authors.affiliation: Division of Hematology/Oncology, University of Pittsburgh, School of Medicine, Pennsylvania.
authors.forename: S L
authors.initials: SL
authors.lastname: Berg
authors.forename: C K
authors.initials: CK
authors.lastname: Phebus
authors.forename: S L
authors.initials: SL
authors.lastname: Wenger
mesh_terms: D002675:Child, Preschool; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002894:Chromosomes, Human, Pair 4; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; D008297:Male
chemical_list: D005819:Genetic Markers