Corticosteroid and immune responses of mice following mini-osmotic pump implantation.
Serum corticosteroid (CS) levels were measured in (B6xA)F1 mice following the implantation of ALZET mini-osmotic pumps. Studies of shipment stress were used as a basis for comparison. At 24 and 48 h following the implantation of pumps CS levels were moderately elevated. However, immunization of animals at 24 h postsurgery with sheep erythrocytes showed normal immune responses. The results of these experiments indicate that the use of mini-osmotic pumps for the delivery of immunomodulatory drugs induces moderate and short-term increases in CS levels, which do not appear to interfere with normal immune function.
Rowland
R R
RR
Department of Pharmacology, University of Minnesota, Minneapolis 55455.
Reyes
E
E
Chukwuocha
R
R
Tokuda
S
S
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D007109:Immunity; D007114:Immunization; D015918:Infusion Pumps, Implantable; D051379:Mice; D013312:Stress, Physiological / Q000097:blood / Q000276:immunology*
D000305:Adrenal Cortex Hormones