Anorexia induced by M-trifluoromethylphenylpiperazine (TFMPP) in rats.
1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP), a putative 5-HT1B, 5-HT1C and 5-HT2 agonist decreased dose-dependently food intake over 4 h in freely feeding rats. The TFMPP-induced anorexia was blocked by mesulergine (a 5-HT1C and 5-HT2 antagonist), metergoline (a 5-HT1A, 5-HT1B, 5-HT1C and 5-HT2 antagonist), mianserin (a 5-HT1C and 5-HT2 antagonist) and attenuated by ketanserin and ritanserin (5-HT2 antagonists). The examined anorexia was not antagonized by cyanopindolol and compound 21009 (5-HT1A and 5-HT1B antagonists). These results indicate that the TFMPP-induced anorexia in freely feeding rats is probably mediated by 5-HT2--and, may be also by 5-HT1C receptors.
Kłodzińska
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Chojnacka-Wójcik
E
E
D000818:Animals; D001067:Appetite Depressants; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology
D001067:Appetite Depressants; D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C018406:1-(3-trifluoromethylphenyl)piperazine