title: Ovine coccidiosis: the pathology of Eimeria crandallis infection.
abstract: Doses of sporulated oocysts of Eimeria crandallis ranging from 50 to 300,000,000 were given to 27 housed lambs aged between 4 and 12 weeks that had been reared coccidia-free. Lambs were killed between 1 and 22 days after inoculation and their tissues examined histologically. Clinical effects were very variable and not closely related to inoculating dose. Some lambs showed intermittent diarrhoea, sometimes watery and sometimes containing muco-fibrinous material, either in the form of intestinal casts or as a greyish discoloration. Loss of surface epithelial cells and villus atrophy in the small intestine were associated with first generation meronts and the release of merozoites from them; in some lambs apoptosis of crypt cells also occurred, leading to crypt atrophy. Severe diffuse crypt hyperplasia was associated with pro-gamonts in the small and large intestines. In a minority of the lambs this stage was associated with what appeared to be crypt destruction by host cells in the lamina propria, leading in some cases to denudation and severe diarrhoea.
authors.affiliation: Central Veterinary Laboratory, Weybridge, Surrey, U.K.
authors.forename: M W
authors.initials: MW
authors.lastname: Gregory
authors.forename: J
authors.initials: J
authors.lastname: Catchipole
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000473:pathology / Q000662:veterinary*; D003967:Diarrhea / Q000473:pathology / Q000662:veterinary; D007420:Intestine, Large / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*