title: Chirality of the sulphoxide metabolites of fenbendazole and albendazole in sheep.
abstract: Two prochiral sulphide drugs, fenbendazole (FBZ) and albendazole (ABZ) were administered orally to sheep. Blood samples were analysed for parent drug and S-oxidation metabolites and the chirality of the sulphoxide metabolites was determined. The plasma concentrations of the enantiomers of the sulphoxides were never a racemate. On the contrary, the ratios were greater than 1 as soon as the sulphoxide compounds could be detected in plasma. They subsequently increased linearly throughout the time course of the kinetics, reaching the level 86:14 after FBZ and 95:5 after ABZ treatment. The major enantiomer represented 74% and 86% of the total AUC of SO.FBZ and SO.ABZ, respectively.
authors.affiliation: Department of Biochemistry, National School of Veterinary Medicine of Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Delatour
authors.forename: E
authors.initials: E
authors.lastname: Benoit
authors.forename: F
authors.initials: F
authors.lastname: Garnier
authors.forename: S
authors.initials: S
authors.lastname: Besse
mesh_terms: D015766:Albendazole / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D005260:Female; D005273:Fenbendazole / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics; D008968:Molecular Conformation; D012756:Sheep / Q000378:metabolism*; D013454:Sulfoxides / Q000378:metabolism*
chemical_list: D013454:Sulfoxides; D005273:Fenbendazole; D015766:Albendazole