Inhibition of autoimmune disease in a murine model of systemic lupus erythematosus induced by exposure to syngeneic photoinactivated lymphocytes.
MRL/l mice develop progressive, virulent autoimmune disease that has many of the features of systemic lupus erythematosus. Prophylactic treatment of MRL/l mice with syngeneic photoinactivated autoimmune splenocytes improves survival and inhibits the fulminant hyperproliferation of abnormal T cells and the production of high titer anti-DNA antibody invariably found in untreated mice. The proliferation of Thy 1+ splenic T cells was significantly decreased, and prolonged retention of the response to T-cell mitogen was found in treated mice. Treatment with unmodified cells induced a partial inhibition of disease features which did not prolong survival rates. These results suggest that phototherapy potentiates a normal immunoregulatory process which enables suppression of the development of abnormal cell populations in young MRL/l mice with relatively intact immune systems.
Berger
C L
CL
Department of Dermatology, Columbia University, New York, New York 10032.
Perez
M
M
Laroche
L
L
Edelson
R
R
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000276:immunology; D005260:Female; D008027:Light; D008070:Lipopolysaccharides / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008213:Lymphocyte Activation / Q000528:radiation effects*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008221:Lymphoid Tissue / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013154:Spleen / Q000166:cytology; D016019:Survival Analysis; D014185:Transplantation, Isogeneic
D001323:Autoantibodies; D008070:Lipopolysaccharides; D003208:Concanavalin A; D004247:DNA