[Disorders of supporting mechanisms of resting membrane potentials of the cardiomyocytes during stress and their prevention].
Incubation of the rats' hearts in low temperature (4 degrees C) in the course of 1.5 h reduced the rest membrane potential (RP) of the cardiomyocytes from 86 +/- 2 to 60 +/- 2 mv. Rapid rewarming to 36 degrees C resulted in hyperpolarization of the membrane potential to 103 +/- 3 mv with maximal speed of restitution of RP about 0.35 mv/sec. These results were determined by electrogenic Na-pump. In the heart of rats, exposed to 6-hour immobilization stress, the speed of restitution of RP decreased to 0.15 +/- 0.01 mv/sec and the hyperpolarization effect was eliminated. This was indicated on the disturbance of Na-pump of the cardiomyocytes membranes. Preliminary treatment with gamma-hydroxybutyric acid or antioxidants alpha-tocopherol and ionol prevented stress-induced disturbances of the cardiomyocytes.
Iasinskiĭ
I L
IL
Malyshev
V V
VV
Meerson
F Z
FZ
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology*; D007103:Immobilization; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D051381:Rats; D012146:Rest; D012964:Sodium / Q000378:metabolism; D012978:Sodium Oxybate / Q000494:pharmacology; D013312:Stress, Physiological / Q000503:physiopathology*; D013696:Temperature; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D012978:Sodium Oxybate; D012964:Sodium
Narushenie mekhanizmov podderzhaniia potentsiala pokoia membran kardiomiotsitov pri stresse i ikh preduprezhdenie.