Radioimmunodetection in rhabdo- and leiomyosarcoma with 111In-anti-myosin monoclonal antibody complex.
In patients with rhabdo- and leiomyosarcoma a radioimmunodiagnostic study was performed with 111In labeled F(ab) fragments of a monoclonal antibody against myosin. Eight patients with rhabdomyosarcoma and 18 patients with leiomyosarcoma were studied. Scanning was performed at 4, 24, and 48 h after administration of 74 MBeq of the antibody complex. A high uptake with a tumor:background ratio of 10:1 was observed in several patients with rhabdomyosarcoma but the results were less accurate in leiomyosarcoma.
Planting
A
A
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
Verweij
J
J
Cox
P
P
Pillay
M
M
Stoter
G
G
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology; D002675:Child, Preschool; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007223:Infant; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009218:Myosins / Q000276:immunology*; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007205:Indium Radioisotopes; D009218:Myosins