Combined chronic toxicity/carcinogenicity study of the fungicide trimorphamide in rats.
Trimorphamide, a new fungicide, was fed over 2 years to groups of 50 male and 50 female rats at dietary levels of 0, 67, 330 and 665 mg/kg. No adverse effects on mortality, haematology, urinalysis, organ weights, incidence and severity of tumors were observed. Isolated observations of abnormalities in blood chemistry suggested the possibility of certain renal damage in the highest dosage group; however, the clinical significance of these findings is dubious. According to the results of the present study, 67 mg/kg in the diet can be considered as the "no observed effect level".
Vargova
M
M
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
Kobzova
D
D
Jakubovsky
J
J
Gajdova
M
M
Grunt
J
J
D000818:Animals; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D009025:Morpholines / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D005659:Fungicides, Industrial; D009025:Morpholines; C024814:trimorfamid