title: Single photon emission computed tomography (SPECT) with 99mTc-HMPAO (hexamethyl propylenamino oxime) in chronic paroxysmal hemicrania--a case report.
abstract: The case of a 69-year-old woman with chronic paroxysmal hemicrania (CPH) is presented in whom cerebral perfusion was investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime (HMPAO) and single photon emission tomography (SPECT). There was a bilateral hypoperfusion in the fronto-parietal region between attacks--without medication as well as under effective treatment with verapamil. During an attack, however, SPECT investigation showed a normal cerebral perfusion. Further investigation is required to find out whether these SPECT findings are due to primary alterations of brain perfusion in CPH or are only of epiphenomenological nature. The observed effectiveness of verapamil in the prophylactic treatment of CPH should be verified in a greater number of patients.
authors.affiliation: Department of Neurology, University of Münster, Federal Republic of Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Schlake
authors.forename: I G
authors.initials: IG
authors.lastname: Böttger
authors.forename: K H
authors.initials: KH
authors.lastname: Grotemeyer
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
authors.forename: O
authors.initials: O
authors.lastname: Schober
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime