A novel oral adjuvant for hepatitis B virus (HBV) vaccines.
A plasma-derived HBV vaccine was administered to 86 healthy men ranging in age from 40-56 years. A relatively high rate of nonresponders was found among the men who received the HBV vaccine alone. There was a significantly higher HBs antibody response rate among the vaccinees who received an oral adjuvant (taurine) compared to those not receiving the adjuvant. In the vaccinees who received the oral adjuvant, an in vitro polyclonal antibody response to taurine was detected in 17 (58.6%) of the 29 HBs responders, but in none of the HBs nonresponders. The development of oral adjuvants other than aluminum may be a valuable approach to the study of HBV vaccination.
Ishizaka
S
S
Third Department of Internal Medicine, Nara Medical University, Japan.
Kuriyama
S
S
Kikuchi
E
E
Nishimura
K
K
Tsujii
T
T
D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage* / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D013654:Taurine / Q000008:administration & dosage* / Q000276:immunology / Q000627:therapeutic use; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000277:Adjuvants, Pharmaceutic; D000914:Antibodies, Viral; D014612:Vaccines; D013654:Taurine