title: Mirex induces ornithine decarboxylase in female rat liver.
abstract: Ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide mirex. After dual oral exposure (120 mg/kg of mirex; 21 and 4 hr prior to sacrifice), ornithine decarboxylase activity in rat liver cytosol was 70-fold higher than control values. A single oral dose of mirex (180 mg/kg) induced hepatic ornithine decarboxylase activity 55-fold over controls. After a single oral dose of mirex the maximal induction of ODC activity occurred at 36 hr. Mirex is an unusually potent and long-lasting inducer of rat hepatic ornithine decarboxylase activity.
authors.affiliation: Toxicology Program, College of Public Health, University of South Florida, Tampa 33612.
authors.forename: A
authors.initials: A
authors.lastname: Mitra
authors.forename: I
authors.initials: I
authors.lastname: Richards
authors.forename: K
authors.initials: K
authors.lastname: Kitchin
authors.forename: R
authors.initials: R
authors.lastname: Conolly
authors.forename: A P
authors.initials: AP
authors.lastname: Kulkarni
mesh_terms: D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008917:Mirex / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004247:DNA; D009955:Ornithine Decarboxylase; D008917:Mirex