Thalidomide, pregnancy and renal failure.
A 26-year-old woman with upper limb phocomelia as a result of thalidemide embryopathy developed renal failure that required dialysis during pregnancy. The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation. The patient was left with end-stage renal failure and recently has undergone cadaveric renal transplantation. This case highlights the widespread effects, including urinary-tract abnormalities, that thalidomide may have and illustrates the peculiar difficulties in managing such a patient during and after pregnancy.
Brown
M A
MA
St George Hospital, Kogarah, NSW.
Farrell
C
C
Newton
P
P
Child
R P
RP
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000628:therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000628:therapy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D011379:Prognosis; D013792:Thalidomide / Q000009:adverse effects*
D000959:Antihypertensive Agents; D013792:Thalidomide