Immunosuppressive retroviral-related factors in sera of patients with head and neck cancer.
The chemotactic responsiveness of mononuclear phagocytes has often been found defective in patients with various malignancies. We have previously reported a defective chemotactic responsiveness in patients with head and neck cancer. Low-molecular-weight factors (LMWFs) have been isolated from tumors and can be held responsible for the inhibitory effect on monocyte chemotactic responsiveness. It is an intriguing new finding that these LMWFs can be neutralized by antibodies reactive to P15E, a structural envelope protein of murine leukemia retroviruses. In this report we describe a relatively easy and rapid method for the detection of immunosuppressive P15E-like factors in the sera of patients with head and neck cancer. The test is based on the monocyte polarization assay. Although only nine head and neck cancer patients were included in this study, the findings indicate that the test might be of value for clinical application. An early detection of a recurrence after treatment might be possible by the finding of a reappearance of the P15E-like factors in patients' sera during follow-up.
Tan
I B
IB
Department of Otolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
Balm
A J
AJ
Snow
G B
GB
Drexhage
H A
HA
D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology; D002633:Chemotaxis; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D015682:Retroviridae Proteins, Oncogenic / Q000097:blood* / Q000276:immunology
D000911:Antibodies, Monoclonal; D015682:Retroviridae Proteins, Oncogenic