title: Reduction of delayed neuronal death by inhibition of protein synthesis.
abstract: Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed 'killer protein' is required, possibly due to deprivation of nerve growth factor or other trophic factors.
authors.affiliation: Department of Neurosurgery, Saitama Medical Center, Saitama Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shigeno
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: G
authors.initials: G
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Kusaka
authors.forename: T
authors.initials: T
authors.lastname: Mima
authors.forename: K
authors.initials: K
authors.lastname: Takakura
authors.forename: D I
authors.initials: DI
authors.lastname: Graham
authors.forename: S
authors.initials: S
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000473:pathology*; D009474:Neurons / Q000187:drug effects / Q000473:pathology*; D011500:Protein Synthesis Inhibitors; D011712:Pyramidal Tracts / Q000187:drug effects / Q000473:pathology*; D012016:Reference Values
chemical_list: D011500:Protein Synthesis Inhibitors; D000841:Anisomycin