title: MR imaging in a patient with Leigh's disease (subacute necrotizing encephalomyelopathy).
abstract: Leigh's disease, also known as subacute necrotizing encephalomyelopathy, is a rare progressive neurological disorder of childhood that was first described by Leigh in 1951. Diagnosis of this disease can be difficult because onset is usually insidious and can present with a number of different focal findings, however diagnostic imaging has been shown to be of benefit in this regard. We present a patient with Leigh's disease in whom serial MR imaging studies helped to make the diagnosis and also demonstrated the dynamic characteristic of this disease process.
authors.affiliation: Department of Radiology, University of South Florida, College of Medicine, Tampa.
authors.forename: S V
authors.initials: SV
authors.lastname: Manzi
authors.forename: K H
authors.initials: KH
authors.lastname: Hager
authors.forename: F R
authors.initials: FR
authors.lastname: Murtagh
authors.forename: J G
authors.initials: JG
authors.lastname: Mazalewski
mesh_terms: D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007888:Leigh Disease / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis