title: Influence of low osmolality contrast media on electrophysiology and hemodynamics in coronary angiography: differences between an ionic (ioxaglate) and a nonionic (iohexol) agent.
abstract: It has recently been suggested that the addition of sodium to low osmolality contrast media may reduce the incidence of ventricular fibrillation and conduction disturbances during coronary angiography. In a randomized, double blind study of 30 patients undergoing coronary angiography we therefore examined the electrophysiological and hemodynamic effects of the two low osmolality contrast media-ioxaglate (with sodium) and iohexol (without sodium). Standard ECG, aortic blood pressure, and His bundle electrocardiogram were recorded. The contrast media were well tolerated and no serious arrhythmias were observed. Both induced a transient decrement in systolic blood pressure and reduction in heart rate 10 s following contrast injection (all P less than 0.01). Ioxaglate prolonged the QT interval at 10 s (P less than 0.01) and also when analysed for the whole observation period (120 s) (P less than 0.05), whereas iohexol did not cause any significant changes in the QT-interval. The AH-interval was prolonged by ioxaglate at 10 s (P less than 0.01), but not altered by iohexol. Thus, other factors than osmolality and sodium content might contribute to QT prolongation, since only the contrast agents with sodium (ioxaglate) induced QT prolongation in this study.
authors.affiliation: Department of Clinical Physiology, Haukeland Hospital, University of Bergen, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Vik-Mo
authors.forename: M
authors.initials: M
authors.lastname: Følling
authors.forename: P
authors.initials: P
authors.lastname: Barth
authors.forename: J E
authors.initials: JE
authors.lastname: Nordrehaug
authors.forename: A
authors.initials: A
authors.lastname: Bjørkhaug
authors.forename: G A
authors.initials: GA
authors.lastname: Rosland
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007472:Iohexol / Q000009:adverse effects / Q000494:pharmacology*; D007485:Ioxaglic Acid / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration
chemical_list: D007472:Iohexol; D007485:Ioxaglic Acid