[Interactions of digoxin with nifedipine and diltiazem].
Biological serum halt-life, relative volume of distribution and digoxin clearance following a single oral dose of digoxin with diltiazem or nifedipine were evaluated. Blood serum digoxin following its administration with diltiazem and nifedipine for 8 days were assayed. It was found that diltiazem and nifedipine did not affect tested pharmacokinetic parameters of digoxin and did not change digoxin serum levels during a 8-day administration in combination with diltiazem and nifedipine.
Halawa
B
B
Z Katedry i Kliniki Kardiologii AM we Wrocławiu.
Mazurek
W
W
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D004077:Digoxin / Q000493:pharmacokinetics*; D004110:Diltiazem / Q000008:administration & dosage*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*
D004077:Digoxin; D004110:Diltiazem; D009543:Nifedipine
Interakcje digoksyny z nifedypina i diltiazemem.