title: Microalbuminuria in adolescents with insulin-dependent diabetes mellitus.
abstract: Two hundred ten adolescents aged 12 to 18 years with insulin-dependent diabetes mellitus were screened for microalbuminuria (albumin excretion rate of 15 to 300 micrograms/min). Sixteen (7.6%) showed persistent microalbuminuria (mean albumin excretion rate of 70.9 +/- 56.2 micrograms/min). There were no significant differences between those with and without microalbuminuria with respect to age, sex, disease duration, and blood pressure over the previous 9 months and hemoglobin A1c level measured over the preceding 3 years. Within the group with microalbuminuria, there was no correlation between albumin excretion rate and blood pressure. However, there was a significant positive correlation between log albumin excretion rate and mean hemoglobin A1c values measured over the preceding 3 years. Our findings suggest that when microalbuminuria has developed, poorer metabolic control is associated with a higher albumin excretion rate. An actual rise in systemic blood pressure may not always precede the development of microalbuminuria.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cook
authors.forename: D
authors.initials: D
authors.lastname: Daneman
mesh_terms: D000293:Adolescent; D000419:Albuminuria / Q000150:complications*; D001794:Blood Pressure; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000652:urine; D005260:Female; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D008297:Male
chemical_list: D006441:Hemoglobin A