Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta).
A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg (contraceptive dose, CD), 250 mg (CD x 2.5) and 500 mg (CD x 5.0), and the monkeys were kept under observation for one year. The observed behavioural, haematological, biochemical and histopathological parameters in treated monkeys were comparable to controls. The results suggest the polymer SMA to be safe up to 5 times CD in monkeys.
Sethi
N
N
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Srivastava
R K
RK
Singh
R K
RK
Bhatia
G S
GS
Sinha
N
N
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001769:Blood / Q000187:drug effects; D001772:Blood Cell Count / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000033:anatomy & histology; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008253:Macaca mulatta; D008297:Male; D008299:Maleic Anhydrides / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D011137:Polystyrenes / Q000627:therapeutic use*; D013154:Spleen / Q000033:anatomy & histology; D013737:Testis / Q000033:anatomy & histology
D003272:Contraceptive Agents, Male; D008299:Maleic Anhydrides; D011137:Polystyrenes; C025704:Styromal