Erythroid 5-aminolevulinate synthase is located on the X chromosome.
The gene for erythroid 5-aminolevulinate synthase has been mapped to Xpter-Xq26 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to Xp21-Xq21, with the most likely location being on band Xp11.2. The mapping of the erythroid 5-amino-levulinate synthase gene to the X chromosome suggests that a defect in this gene may be the primary cause of X-linked sideroblastic anemia.
Cox
T C
TC
Department of Biochemistry, University of Adelaide, Australia.
Bawden
M J
MJ
Abraham
N G
NG
Bottomley
S S
SS
May
B K
BK
Baker
E
E
Chen
L Z
LZ
Sutherland
G R
GR
D000624:5-Aminolevulinate Synthetase / Q000097:blood / Q000235:genetics*; D000756:Anemia, Sideroblastic / Q000201:enzymology / Q000235:genetics; D000818:Animals; D015139:Blotting, Southern; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization; D014960:X Chromosome
D015342:DNA Probes; D004247:DNA; D000624:5-Aminolevulinate Synthetase