[Clinical significance of HLA phenotype in childhood tuberculosis].
According to HLA system (loci A, B, C, DR), examination findings of 171 children aged between 1 and 15 years with different clinical manifestations of primary tuberculosis (including 49 with a pulmonary type of tuberculosis in different stages of inflammation, 46 with osteoarticular lesions of tuberculous etiology and 76 with generalized forms of tuberculosis) indicate a significant rise in the incidence of HLA-B7, B14 antigens. Moreover, the incidence of HLA-B14 antigen increases sharply as the degree of clinical manifestations and severity of inflammatory changes become more evident. In intrathoracic adenopathy, the presence of HLA-DR, DR2 antigens seems to promote earlier clinico-roentgenologic manifestations and a more serious course of an inflammatory process. In combined osteoarticular processes of specific etiology, an increase in the incidence of HLA-DR5, DR7 antigens is significant. The most evident drop in the immune T-system indices is traced in subjects bearing HLA-DR2 antigen. The given fact makes it possible to proceed on the assumption that genetically controlled immune response factors play a certain role in pathogenesis of tuberculosis.
Dovgaliuk
I F
IF
Semilutskaia
I B
IB
Tselikova
V A
VA
Danilevskaia
I M
IM
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015235:HLA-B Antigens / Q000032:analysis; D059909:HLA-B14 Antigen; D015793:HLA-B7 Antigen / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015802:HLA-DR2 Antigen / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D015809:HLA-DR7 Antigen / Q000032:analysis; D006801:Humans; D007223:Infant; D010641:Phenotype; D014376:Tuberculosis / Q000235:genetics*; D014394:Tuberculosis, Osteoarticular / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000235:genetics
D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015793:HLA-B7 Antigen; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D015805:HLA-DR5 Antigen; D015809:HLA-DR7 Antigen
Klinicheskoe znachenie HLA-fenotipa pri tuberkuleze u deteĭ.