title: The investigation of antiepileptic action of qingyangshen (QYS)--influences of QYS on the development of rat brain and memory behavior.
abstract: As an anticonvulsant, the influences of Qingyangshen (QYS) on the development of brain and memory behavior were observed in four-week-old male rats. The dosage of QYS was 100 mg/kg/QOD and the period of administration was one month. The results showed that QYS had less influence on the development of body weight and brain wet weight in young-aged rats than diphenylhydantoin (DPH). However, QYS inhibited the establishment of passive avoidance conditional reflex and had influence on memory behavior in young-aged rats.
authors.affiliation: Department of Neurology, Chinese PLA General Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Lang
authors.forename: P
authors.initials: P
authors.lastname: Kuang
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008568:Memory / Q000187:drug effects*; D009929:Organ Size; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000628:therapy
chemical_list: D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D010672:Phenytoin