title: Topical propylene glycol and hyperosmolality.
abstract: Topical propylene glycol is known to cause elevated serum osmolality in burns patients. Twelve adults with skin disease had quantities of propylene glycol applied to their skin to a maximum of 6.1 g/kg per 24 h for 5 days. Serum electrolyte, lactate and osmolality results remained unchanged during the study. These results suggest that topical propylene glycol may be used in adult dermatological practice without affecting serum osmolality.
authors.affiliation: Skin and Cancer Foundation, Ashley Centre, Westmead, NSW, Australia.
authors.forename: C A
authors.initials: CA
authors.lastname: Commens
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000097:blood*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011409:Propylene Glycols; D019946:Propylene Glycol