[Clinico-pathological evaluation of mesangial IgA deposition of minimal change with nephrotic syndrome].
The case of IgA glomerulonephritis that shows minimal change with nephrotic syndrome is unusual. Thirteen patients of mesangial IgA deposition of minimal change with nephrotic syndrome (IgAMCNS) are discussed in comparison with twenty patients of non IgA deposition of minimal change with nephrotic syndrome (MCNS). On a common basis of hematuria, two groups are undistinguished. On a reaction pattern to steroid treatment, the former is based on IgA nephritis and the latter is based on minimal change with nephrotic syndrome. There is no difference in light microscopical findings between the two groups. Electron microscopically, the former suggests IgA nephritis and the latter suggests minimal change with nephrotic syndrome. In immunofluorescence, the former group is rare to show typical IgA glomerulonephritis. In conclusion, IgAMCNS is considered to be nephrotic syndrome with asymptomatic IgA deposit in mesangium.
Hamaguchi
K
K
Department of Pathology, Sakura National Hospital, Chiba, Japan.
Tuchida
H
H
Suzuki
S
S
Miura
Y
Y
Nakazawa
R
R
Suhara
Y
Y
Mimura
N
N
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D007070:Immunoglobulin A