[Inhalation therapy of antibiotics].
We produced experimental murine Klebsiella pneumoniae pneumonia by air-borne infection using exposure apparatus (LD50: 9.7 X 10 C.F.U./lung). The MIC value of cefazolin was 1.56 micrograms/ml, and that of gentamicin was 0.39 micrograms/ml. We treated this murine pneumonia with aerosolized antibiotics. The infected mice received inhalation of 50 mg (5 mg/ml), 100 mg (10 mg/ml), 200 mg (20 mg/ml) and 400 mg (40 mg/ml) gentamicin were alive. Survival rate of the infected mice treated with inhalation of 1000 mg (100 mg/ml) cefazolin was low, but that of them received inhalation of 500 mg (50 mg/ml) cefazolin was high. On the basis of these experiments it is suggested that aerosol of 50 mg/ml cefazolin gets to alveoli, and inhalation therapy of low level of cephems is proper for bacterial respiratory infections. Inhalation therapy of 50 mg/ml cephem for chronic bronchitis had a marked clinical effect. This proves that aerosol of cephem gets to infected bronchi.
Noguchi
Y
Y
Respiratory Clinic, Saitama Cancer Center, Japan.
Taguchi
M
M
Takasugi
M
M
Sakamoto
T
T
Matsumoto
K
K
D000280:Administration, Inhalation; D000336:Aerosols; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002437:Cefazolin / Q000008:administration & dosage; D002908:Chronic Disease; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D011014:Pneumonia / Q000188:drug therapy; D051381:Rats; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000336:Aerosols; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002437:Cefazolin