title: Cardiotonic 'C' ring modified isomazole analogues.
abstract: Isomazole analogues which have achiral electron withdrawing substituents at the 4'-position and analogues with heterocyclic 'C' rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the 'C' ring without loss of activity. The 4'-methylsulphonyl, -cyano, -carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies.
authors.affiliation: Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, UK.
authors.forename: P
authors.initials: P
authors.lastname: Barraclough
authors.forename: J W
authors.initials: JW
authors.lastname: Black
authors.forename: D
authors.initials: D
authors.lastname: Cambridge
authors.forename: D A
authors.initials: DA
authors.lastname: Demaine
authors.forename: V P
authors.initials: VP
authors.lastname: Gerskowitch
authors.forename: H
authors.initials: H
authors.lastname: Giles
authors.forename: A P
authors.initials: AP
authors.lastname: Hill
authors.forename: R A
authors.initials: RA
authors.lastname: Hull
authors.forename: R
authors.initials: R
authors.lastname: Lyer
authors.forename: W R
authors.initials: WR
authors.lastname: King
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004285:Dogs; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male
chemical_list: D002316:Cardiotonic Agents; D007093:Imidazoles; C029758:sulmazole