title: Kidney transplantation from anencephalic donors. Report of 5 cases and a review of the literature.
abstract: The results of five 'en bloc' kidney transplants from 5 anencephalic newborns are reported. The receptors were 8-50 years old. The graft survival 12 months after transplantation was 60%. The average plasma creatinine level the 1st month after transplantation was 4.0 +/- 0.8 mg/dl, after 6 months 1.5 +/- 0.8, and is currently 1.2 +/- 0.6 mg/dl. The follow-up time ranged from 17 to 55 months (mean 30.3 +/- 17.5 months). Two grafts were lost during the early posttransplantation period (due to arterial thrombosis and vascular rejection, respectively); the other grafts are still functioning. Two grafts showed initial oliguria. All of the patients required hemodialysis or peritoneal dialysis for 5-60 days (mean 22.5 +/- 21.4 days). The time of cold ischemia ranged from 15 to 35 h (mean 25.6 +/- 7.7 h). The literature published on the subject is reviewed, and it is concluded that anencephalic donors are an acceptable option for transplantation.
authors.affiliation: Service of Nephrology, Hospital General Gregorio Marañón, Madrid, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Gomez-Campderà
authors.forename: N R
authors.initials: NR
authors.lastname: Robles
authors.forename: F
authors.initials: F
authors.lastname: Anaya
authors.forename: M
authors.initials: M
authors.lastname: Rengel
authors.forename: J
authors.initials: J
authors.lastname: Albertos
authors.forename: A
authors.initials: A
authors.lastname: Luque
authors.forename: J L
authors.initials: JL
authors.lastname: Vallejo
authors.forename: F
authors.initials: F
authors.lastname: Valderrabano
mesh_terms: D000293:Adolescent; D000328:Adult; D000757:Anencephaly; D002648:Child; D005260:Female; D006085:Graft Survival; D006801:Humans; D007231:Infant, Newborn; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D014019:Tissue Donors