title: Hypofrontal vs. hypo-Sylvian blood flow in schizophrenia.
abstract: Hypofrontality in schizophrenia has been a frequent but not consistent finding in regional cerebral blood flow studies. However, the contributions of subject and state variables such as age, education, task activation, and anxiety, some of which are known to influence blood flow profiles, have not been thoroughly examined in this population. Here, in a sample including 24 normal, 18 schizophrenic, 22 bipolar, and 13 unipolar depressive subjects, narrative prose memory deficit was found to distinguish both schizophrenic and bipolar subjects from normal controls. Further, when these subjects were engaged in repeated trials of a verbal recognition memory task, left hemisphere hypofrontal blood flow in the early stage of learning was related to narrative memory, independent of diagnostic group. In the late stage of learning, state anxiety was significantly associated with left hypofrontality, while right hypofrontality was significantly related to narrative memory--both findings again independent of diagnostic group. A focal suppression of left hemispheric peri-Sylvian activation (in Broca's and Wernicke's areas) uniquely characterized schizophrenia after taking into account variance due to age, education, gender, state anxiety, and verbal memory. It is concluded that a failure of left peri-Sylvian activation during memory task performance reflects a unique language-related focal deficit in schizophrenia.
authors.affiliation: Section on Neuropsychology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
authors.forename: F B
authors.initials: FB
authors.lastname: Wood
authors.forename: D L
authors.initials: DL
authors.lastname: Flowers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology; D002535:Cerebral Aqueduct / Q000098:blood supply*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology