Neuropeptide Y activates inwardly-rectifying K(+)-channels in C-cells of amphibian sympathetic ganglia.
Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying K(+)-channels in C-cells. This effect of the peptide on C-cell K(+)-channels was similar to that produced by muscarine and adrenaline and may be related to autoreceptor function.
Zidichouski
J A
JA
Department of Pharmacology, University of Alberta, Edmonton, Canada.
Chen
H
H
Smith
P A
PA
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009478:Neuropeptide Y / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011894:Rana pipiens
D009478:Neuropeptide Y; D015221:Potassium Channels; D009116:Muscarine; D004837:Epinephrine