title: Heparinless extracorporeal bypass for treatment of hypothermia.
abstract: In an attempt to assess the changes occurring to the coagulation profile during internal active core rewarming with partial cardiopulmonary bypass (CPB) without heparin anticoagulation, five pigs were anesthetized, and a model for severe to moderate hypothermia was created. Femoral-femoral bypass with Bio-Pump, heat exchanger, and a membrane oxygenator were used during the rewarming for 64.8 +/- 8.5 minutes. There were no statistically significant changes in platelet count, platelet index, activated clotting time (ACT), partial thromboplastin time (PTT), prothrombin time (PT), fibrinogen, fibrinogen index and fibrin split products (p greater than 0.05). There were no thromboembolic sequelae seen at autopsy. The components of the CPB circuit showed no signs of formation of aggregates or thrombi. The results of this study are attributed to the nonthrombogenic, atraumatic design of the Bio-Pump and the enhanced physiological fibrinolysis seen in the first hour of CPB. We concluded that heparinless CPB may serve as a safe alternative for active core rewarming for severe to moderate hypothermia.
authors.affiliation: Department of Surgery, Cooper Hospital/University Medical Center, Camden, NJ 08103.
authors.forename: A J
authors.initials: AJ
authors.lastname: DelRossi
authors.forename: A C
authors.initials: AC
authors.lastname: Cernaianu
authors.forename: R A
authors.initials: RA
authors.lastname: Vertrees
authors.forename: S J
authors.initials: SJ
authors.lastname: Fuller
authors.forename: J
authors.initials: J
authors.lastname: Costabile
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: J H
authors.initials: JH
authors.lastname: Cilley
authors.forename: W A
authors.initials: WA
authors.lastname: Baldino
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006353:Heart-Assist Devices; D006493:Heparin / Q000009:adverse effects; D007035:Hypothermia / Q000628:therapy*; D008297:Male; D010976:Platelet Count; D013552:Swine; D013556:Swine, Miniature
chemical_list: D005340:Fibrinogen; D006493:Heparin