Regulation of the epidermal growth factor receptor by growth-modulating agents.
The epidermal growth factor (EGF) receptor, a tyrosine kinase which mediates the mitogenic and tumorigenic action of EGF on epithelial cells and fibroblasts, is a target for the regulatory action of other growth-modulating agents. We have identified at least three mechanisms by which heterologous agents such as tumor promoters regulate the EGF receptor: modulation of receptor binding or kinase activity through phosphorylation, down regulation of the receptor through internalization, and enhanced receptor synthesis through transcriptional activation. Both calcium- and sodium-dependent signaling pathways play a role in one or more of these processes.
Rosner
M R
MR
Ben May Institute, University of Chicago, Illinois 60637.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D066246:ErbB Receptors / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology*; D014118:Toxins, Biological / Q000494:pharmacology*
D002273:Carcinogens; D006133:Growth Substances; D014118:Toxins, Biological; D066246:ErbB Receptors