title: [The effect of chemical ablation with lugol solution for ventricular tachyarrhythmia on cardiac function].
abstract: Among various methods to treat ventricular tachyarrhythmia (VT) in the presence of acute myocardial infraction, the surgical approach is a somewhat unsatisfactory method in case of preoperative acute hemodynamic deterioration. The transatrial approach with the "topical" application of Lugol solution on left ventricular (LV) endocardium, without left ventriculotomy, i.e. a transatrial chemical ablation method; has been reported in our department as suggestive to being efficacious. The objective of the present study is to investigate the occurrence of left bundle branch block (LBBB) and the like, as well as to examine the impact on heart function, particularly LV function, by employing the just-above mentioned approach. 15 mongrel dogs were being experimented on. Through a left transatrial approach toward LV endocardium and the application of Lugol solution, with pulmonary artery flow being as constant; we measured pre- and post-operative left atrial (LA) pressure, LV pressure, aortic pressure, LV functional shortening, and stroke volume. In addition, the same protocol was also employed in another group, with the application of physiologic normal saline solution, instead. A comparative study was made between the two groups. In the Lugol solution group, postoperative LA pressure and LVEDP showed a tendency toward exhibiting higher values, when compared to preoperative readings. However, no significant difference was observed in this setting. Furthermore, in comparison with postoperative readings in the saline group, the mean LA pressure in the Lugol solution group exhibited a tendency toward somewhat higher values. Nonetheless, no significant difference was observed in LV functional shortening between the two groups; though it is known a LBB pattern could be noticed on ECG in the Lugol solution group.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Second Department of Surgery, Nippon Medical School, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yajima
authors.forename: M
authors.initials: M
authors.lastname: Ikeshita
authors.forename: T
authors.initials: T
authors.lastname: Shoji
mesh_terms: D000818:Animals; D004285:Dogs; D004699:Endocardium / Q000187:drug effects*; D005112:Extracorporeal Circulation; D006324:Heart Arrest, Induced; D006439:Hemodynamics / Q000187:drug effects*; D007454:Iodides / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology*; D012996:Solutions; D013610:Tachycardia / Q000503:physiopathology* / Q000601:surgery
chemical_list: D007454:Iodides; D012996:Solutions; D011189:Potassium Chloride