Triploidy arising from a first meiotic non-disjunction in a mother carrying a reciprocal translocation.
We report on a 22 year old mother, a carrier of a 6;14 balanced reciprocal translocation, who aborted a triploid conceptus carrying a similar translocation. We showed the maternal origin of this triploidy, after non-disjunction at meiosis I. The phenotypic expression as a non-molar pregnancy, the contribution of the maternal translocation, and possible aetiological factors of triploidy are discussed.
Rochon
L
L
Department of Pathology, McGill University, Montreal, Quebec, Canada.
Vekemans
M J
MJ
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D009630:Nondisjunction, Genetic; D011247:Pregnancy; D014178:Translocation, Genetic; D014314:Trisomy