title: Thyroid hormone stimulates the production of insulin-like growth factor I (IGF-I) by immature rat Sertoli cells.
abstract: The effects of thyroid hormone on insulin-like growth factor I (IGF-I) production by Sertoli cells isolated from immature rats have been investigated. In Sertoli cells from hypothyroid rats the production of IGF-I was significantly lower than in controls and was greatly stimulated by the administration of triiodothyronine (T3) in vivo. The in vitro addition of physiological doses of T3 (1 nmol/l) significantly increased the production of IGF-I by cultured Sertoli cells indicating a direct action of the hormone on local IGF-I production. Our results suggest the involvement of IGF-I in the thyroid hormone-dependent maturation of testicular function.
authors.affiliation: Istituto di Fisiologia Generale, Università di Genova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Palmero
authors.forename: M
authors.initials: M
authors.lastname: Prati
authors.forename: A
authors.initials: A
authors.lastname: Barreca
authors.forename: F
authors.initials: F
authors.lastname: Minuto
authors.forename: G
authors.initials: G
authors.lastname: Giordano
authors.forename: E
authors.initials: E
authors.lastname: Fugassa
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000187:drug effects / Q000378:metabolism*; D013002:Somatomedins / Q000096:biosynthesis*; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D013002:Somatomedins; D014284:Triiodothyronine; D007334:Insulin-Like Growth Factor I; D003513:Cycloheximide