[The intensification of lipid peroxidation in the skin for the suppression of experimental dermatitis].
Guinea pig experiments making use of spectrofluorometry have revealed reduced level of Schiff's bases in skin biopsy specimens obtained from foci of allergic contact dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Iron sulfate electrophoresis resulted in a decrease of the sensitization and of the allergic contact dermatitis intensity, as well as in enhancement of lipid peroxidation in the skin. These data permit a supposition that reduction of lipid peroxidation is one of the pathogenetic mechanisms of delayed type hypersensitivity, and that lipid peroxidation enhancement in the skin by iron sulfate electrophoresis is one of the possible mechanisms of suppressing allergic contact dermatitis.
Volnukhin
V A
VA
Akimov
V G
VG
Lashmanova
A P
AP
D000818:Animals; D003877:Dermatitis, Contact / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D004137:Dinitrochlorobenzene; D004353:Drug Evaluation, Preclinical; D005296:Ferrous Compounds / Q000008:administration & dosage; D006168:Guinea Pigs; D007478:Iontophoresis; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D012545:Schiff Bases / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D004137:Dinitrochlorobenzene; D005296:Ferrous Compounds; D012545:Schiff Bases; C020748:ferrous sulfate
Usilenie perekisnogo okisleniia lipidov v kozhe dlia podavleniia éksperimental'nogo dermatita.