Normoprolactinemic anovulation nonresponsive to clomiphene citrate: ovulation induction with bromocriptine.
Ovulation under bromocriptine was studied in 14 women with normoprolactinemic amenorrhea (5 primary, 9 secondary), unresponsive to clomiphene citrate (CC). On bromocriptine alone, ovulation occurred in 4 (28.6%). In the same subjects, bromocriptine was subsequently associated with CC. Seven patients ovulated (50.0%), including 3 that had responded to bromocriptine alone. Ovulation occurred once or twice in 6 of the 9 cases of secondary amenorrhea (66.6%). In several occasions, when ovulation induction failed, luteinized unruptured follicles were found under ultrasonographic monitoring. Four patients who had a negative response to progestin challenge did not ovulate with the treatment. Women with plasma prolactin in the upper normal range had a greater probability of achieving ovulation induction.
Porcile
A
A
University of Chile, School of Medicine, Hospital del Salvador, Santiago.
Gallardo
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E
Venegas
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E
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D000858:Anovulation / Q000188:drug therapy* / Q000378:metabolism; D001971:Bromocriptine / Q000494:pharmacology / Q000627:therapeutic use; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction; D011388:Prolactin / Q000378:metabolism*
D002996:Clomiphene; D001971:Bromocriptine; D011388:Prolactin