title: Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes.
abstract: Rokitamycin (RKM), a 3"-O-propionyl derivative of leucomycin A5, is bactericidal against staphylococci near the minimum inhibitory concentrations. RKM bound to ribosomes before-hand is only slightly displaced by erythromycin or josamycin, or even by RKM itself. The adhesive binding of the RKM-ribosome complex might prove to be the lethal event for susceptible staphylococci.
authors.affiliation: Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Endou
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D004917:Erythromycin / Q000378:metabolism; D015570:Josamycin / Q000378:metabolism; D015644:Miocamycin / Q000031:analogs & derivatives* / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*
chemical_list: D015644:Miocamycin; D004917:Erythromycin; D015570:Josamycin; C033383:rokitamycin