A possible genetic component of obesity in childhood. Observations on acid phosphatase polymorphism.
Phenotypes of acid phosphatase with low enzymatic activity (ACP1 A and BA) are correlated with the highest degree of body mass increase observed in a sample of obese children. Since acid phosphatase probably functions as a flavin-mononucleotide phosphatase, differential modulation of flavo-enzyme activity and energy metabolism due to acid phosphatase genetic variability may explain the observed association.
Lucarini
N
N
Chair of Human Development, 2nd University of Rome School of Medicine, Italy.
Finocchi
G
G
Gloria-Bottini
F
F
Macioce
M
M
Borgiani
P
P
Amante
A
A
Bottini
E
E
D000135:Acid Phosphatase / Q000235:genetics*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D000135:Acid Phosphatase