Angiotensin II modulation of glutamate excitation of locus coeruleus neurons.
The effects of iontophoretically applied angiotensin II (AII) have been tested on intracellularly recorded locus coeruleus neurons in an in vitro brain slice preparation. In most neurons, AII strongly depressed the depolarizing effect of L-glutamate in the absence of other effects on membrane properties. This action was specific, in that AII had no effect on depolarizations caused by current injection or application of acetylcholine, and it was blockable by the AII antagonist saralasin. These results appear to demonstrate a potent and previously unreported neuromodulatory action of AII in the central nervous system.
Xiong
H G
HG
Department of Physiology, University of Ottawa, Canada.
Marshall
K C
KC
D000109:Acetylcholine / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D066298:In Vitro Techniques; D008125:Locus Coeruleus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D012504:Saralasin / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D000804:Angiotensin II; D012504:Saralasin; D000109:Acetylcholine