title: Eukaryotic protein elongation factors.
abstract: In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and EF-2. EF-1 is composed of a nucleotide-binding protein EF-1 alpha, and a nucleotide exchange protein complex, EF-1 beta gamma, while EF-2 catalyses the translocation of peptidyl-tRNA on the ribosome. Elongation factors are highly conserved among different species and may be involved in functions other than protein synthesis, such as organization of the mitotic apparatus, signal transduction, developmental regulation, ageing and transformation. Yeast contains a third factor, EF-3, whose structure and function is not yet well understood.
authors.affiliation: Department of Chemistry, Aarhus University, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Riis
authors.forename: S I
authors.initials: SI
authors.lastname: Rattan
authors.forename: B F
authors.initials: BF
authors.lastname: Clark
authors.forename: W C
authors.initials: WC
authors.lastname: Merrick
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000502:physiology*; D006801:Humans; D010445:Peptide Elongation Factors / Q000502:physiology*; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae
chemical_list: D010445:Peptide Elongation Factors