Enalapril induced angioedema.
A report of three patients who developed angiodema while receiving enalapril. Patient 1 came in with an 8-hour history of facial swelling after enalapril had been started 2 days earlier. The second patient came in with severe angiodema of the tongue, larynx, and glottis requiring emergency tracheostomy, hydroxyzine, and steroids. He had been treated with enalapril for 1 year. The third patient developed facial swelling within a few hours of the first dose of enalapril. Angiodema with enalapril can occur early or late in the course of therapy. A possible mechanism for this drug reaction is the potentiation of bradykinin with resultant kinin system activation.
Gianos
M E
ME
Allergy and Immunology Section, Wadsworth VA Medical Center, Los Angeles, CA 90073.
Klaustermeyer
W B
WB
Kurohara
M
M
Tarnasky
P
P
Gordon
E
E
D000368:Aged; D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery; D000799:Angioedema / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D004155:Diphenhydramine / Q000627:therapeutic use; D004656:Enalapril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014139:Tracheostomy
D004656:Enalapril; D004155:Diphenhydramine