Pretreatment with pentoxifylline improves the hemodynamic and histologic changes and decreases neutrophil adhesiveness in a pig fecal peritonitis model.
We investigated pentoxifylline (PTF) as a pretreatment of septic syndrome in pigs with fecal peritonitis. In the untreated group there was a progressive decrease in mean arterial pressure (MAP), cardiac output, mean pulmonary artery wedge pressure (WP), and a progressive rise in mean pulmonary artery pressure (MPAP), pulmonary vascular resistance (PVR), systemic vascular resistance (SVR), heart rate (HR), and core temperature (T). In those pigs given PTF there was a significantly smaller increase in SVR throughout and in PVR after 270 min. No significant differences were seen in MAP, MPAP, WP, HR, and T. Neutrophil adhesiveness did not change in the untreated group. However, it decreased markedly with PTF, both before and after peritonitis induction. Electron microscopy of the lungs, liver, and spleen in the test group showed severe damage, with endothelial disruption, capillary or sinusoidal occlusion, leukostasis, and neutrophil degranulation. Pretreatment with PTF attenuated these changes.
Tighe
D
D
St. George's Hospital Medical School, London, England.
Moss
R
R
Hynd
J
J
Boghossian
S
S
al-Saady
N
N
Heath
M F
MF
Bennett
E D
ED
D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008954:Models, Biological; D009504:Neutrophils / Q000187:drug effects*; D010431:Pentoxifylline / Q000008:administration & dosage* / Q000627:therapeutic use; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013552:Swine; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline