title: Early graft function after heart-lung transplantation.
abstract: Sixty patients underwent heart-lung transplantation at our institution between April 1984 and March 1989. The first five donor organs were removed in an adjacent operating room. Subsequently, organs were removed from distant centers. The method of preservation consisted of cold crystalloid cardioplegic arrest of the heart followed by a cold colloid pulmonary artery flush of a perfusate developed at Papworth Hospital. The lung perfusate is preceded by an infusion of prostacyclin into the pulmonary artery, during preliminary dissection of the donor organs. The total ischemic time ranged from 48 to 51 minutes (mean, 49.6 minutes) for the near-procurement group and from 70 to 249 minutes (mean, 157.6 minutes) for the distant-procurement group. Function of the lungs was assessed by gas exchange, pulmonary function tests, extubation, and survival data. Serial x-ray films were used to monitor graft performance in the postoperative period. We record our clinical experience of early graft function after heart-lung transplantation.
authors.affiliation: Heart-Lung Transplant Unit, Papworth Hospital, Cambridgeshire, U.K.
authors.forename: J P
authors.initials: JP
authors.lastname: McGoldrick
authors.forename: J P
authors.initials: JP
authors.lastname: Scott
authors.forename: R
authors.initials: R
authors.lastname: Smyth
authors.forename: T
authors.initials: T
authors.lastname: Higenbottam
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D003550:Cystic Fibrosis / Q000601:surgery; D004541:Eisenmenger Complex / Q000601:surgery; D005260:Female; D016041:Heart-Lung Transplantation / Q000401:mortality / Q000502:physiology*; D006801:Humans; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D012129:Respiratory Function Tests; D013997:Time Factors