title: Cerebral blood flow variations in CNS lupus.
abstract: We studied the patterns of cerebral blood flow (CBF), over time, in patients with systemic lupus erythematosus and varying neurologic manifestations including headache, stroke, psychosis, and encephalopathy. For 20 paired xenon-133 CBF measurements, CBF was normal during CNS remissions, regardless of the symptoms. CBF was significantly depressed during CNS exacerbations. The magnitude of change in CBF varied with the neurologic syndrome. CBF was least affected in patients with nonspecific symptoms such as headache or malaise, whereas patients with encephalopathy or psychosis exhibited the greatest reductions in CBF. In 1 patient with affective psychosis, without clinical or CT evidence of cerebral ischemia, serial SPECT studies showed resolution of multifocal cerebral perfusion defects which paralleled clinical recovery.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kushner
authors.forename: M
authors.initials: M
authors.lastname: Tobin
authors.forename: F
authors.initials: F
authors.lastname: Fazekas
authors.forename: J
authors.initials: J
authors.lastname: Chawluk
authors.forename: D
authors.initials: D
authors.lastname: Jamieson
authors.forename: B
authors.initials: B
authors.lastname: Freundlich
authors.forename: S
authors.initials: S
authors.lastname: Grenell
authors.forename: L
authors.initials: L
authors.lastname: Freemen
authors.forename: M
authors.initials: M
authors.lastname: Reivich
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes