title: CA 15-3 in human breast cancer. Comparison with tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA).
abstract: CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. CA 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA. No association was found between marker positivity and the number of organs involved by metastases. CA 15-3 positivity was significantly associated with visceral rather than soft tissue recurrences; no significant similar association was observed for CEA and TPA. CA 15-3 serum levels were early predictors of relapse in four out of nine patients within a 6-12 month follow-up period.
authors.affiliation: University of Napoli, Division of Medical Oncology, Medical School II, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: R V
authors.initials: RV
authors.lastname: Iaffaioli
authors.forename: C
authors.initials: C
authors.lastname: Pagliarulo
authors.forename: S
authors.initials: S
authors.lastname: De Placido
authors.forename: G
authors.initials: G
authors.lastname: Frasci
authors.forename: B
authors.initials: B
authors.lastname: Ungaro
authors.forename: E
authors.initials: E
authors.lastname: Matano
authors.forename: A R
authors.initials: AR
authors.lastname: Bianco
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000097:blood*; D009364:Neoplasm Recurrence, Local; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D019396:Tissue Polypeptide Antigen
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; D010455:Peptides; D019396:Tissue Polypeptide Antigen