title: Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin.
abstract: A cDNA encoding the complete open reading frame of murine alpha 1-antitrypsin has been cloned and sequenced. The nucleic acid and predicted amino acid sequences show homology to human alpha 1-antitrypsin and demonstrate the preservation of critical structural determinants for intracellular targeting, carbohydrate attachment, and catalytic function. The alpha 1-antitrypsin gene locus (Aat) has been localized on murine chromosome 12E----F by in situ hybridization.
authors.affiliation: Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: R N
authors.initials: RN
authors.lastname: Sifers
authors.forename: F D
authors.initials: FD
authors.lastname: Ledley
authors.forename: L
authors.initials: L
authors.lastname: Reed-Fourquet
authors.forename: D H
authors.initials: DH
authors.lastname: Ledbetter
authors.forename: S A
authors.initials: SA
authors.lastname: Ledbetter
authors.forename: S L
authors.initials: SL
authors.lastname: Woo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000515:alpha 1-Antitrypsin