[Autoradiographic and immunohistochemical analysis of 3H-melatonin distribution in endocrine and non-endocrine organs].
The comparison of the results of the autoradiographical and immunohistochemical study showed the discrepancy between the distribution of the radioactive label and the histotopographical localization of the melatonin-immunoreactive cells in the suprarenal glands, duodenum, pancreas and spleen after five minutes, one and three hours of the 3H-melatonin injection. It was shown that the exogenous 3H-melatonin is metabolizing rapidly and the products of its metabolism are spreading all over the organism. The exogenous 3H-melatonin may be accumulating in the separate endocrine and non-endocrine cells of the different organs. The results of this investigations open the perspectives for the future study on the behavior of the melatonin in the organism.
Iuzhakov
V V
VV
Kvetnoĭ
I M
IM
Petrova
G A
GA
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D004386:Duodenum / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051379:Mice; D010179:Pancreas / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D008550:Melatonin
Radioavtograficheskiĭ i immunogistokhimicheskiĭ analiz raspredeleniia 3H-melatonina v éndokrinnykh i neéndokrinnykh organov.