Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine.
The aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine were shown to have inhibitory activity against several mouse tumor cell lines, leukemia P388 and L1210, melanoma B16, bladder cancer MBC2, and colon cancer Colon 26 in culture. These aporphine alkaloids also inhibited the mitogen-induced lymphocyte proliferation as well as the growth of IL-2 dependent CTLL2 line in a dose-dependent way. Of the four alkaloids apomorphine proved to be most potent in the inhibitory action. Apomorphine treatment resulted in some prolongation of survival time of the mice inoculated i.p. with P388, although its activity was not enough to meet the standard criterion for antitumor activity.
Kondo
Y
Y
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Imai
Y
Y
Hojo
H
H
Endo
T
T
Nozoe
S
S
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000996:Antitussive Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001060:Aporphines / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005069:Evaluation Studies as Topic; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents; D000996:Antitussive Agents; D001060:Aporphines; D007166:Immunosuppressive Agents; D008934:Mitogens; C067341:corydine; C067342:dicentrine; D001058:Apomorphine; C005004:glaucine