A respiratory tract dosimetry model for air toxics.
The development of a physiologically based pharmacokinetic model for the whole body in which inhalation, exhalation, and metabolism in respiratory tract tissues are taken into account is described. As an example of the model's use, the results of several experiments in which rats and humans were exposed to styrene were simulated; these results are discussed. The predicted results agree with the empirical data and with the modeling results of others.
Overton
J H
JH
Inhalation Toxicology Division, U.S. Environmental Protection Agency Research Triangle Park, NC 27711.
D000393:Air Pollutants / Q000032:analysis*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015386:Hazardous Substances / Q000493:pharmacokinetics*; D006801:Humans; D008954:Models, Biological; D051381:Rats; D012137:Respiratory System / Q000378:metabolism*; D020058:Styrene; D013343:Styrenes / Q000493:pharmacokinetics
D000393:Air Pollutants; D015386:Hazardous Substances; D013343:Styrenes; D020058:Styrene