title: Pressor response to norepinephrine in essential hypertension. A study in families.
abstract: Study of pressor response to graded, increased doses of infused norepinephrine in patients with essential hypertension, their normotensive siblings, and normotensive control subjects unrelated to the patients and without a family history of hypertension indicated an increased response in the two former groups. Comparison of the dose-response curves in the three groups showed that the difference in response was due to a reduced threshold to norepinephrine in patients and their siblings and not to differences in the slopes of the dose-response curves. These alterations were not paralleled by differences in heart rate responses.
authors.affiliation: Instituto do Coração do Hospital, Universidade de São Paulo, Brazil.
authors.forename: J J
authors.initials: JJ
authors.lastname: De Lima
authors.forename: M M
authors.initials: MM
authors.lastname: Dias
authors.forename: H
authors.initials: H
authors.lastname: Bernardes-Silva
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D005190:Family; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology*; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D009638:Norepinephrine