[Type I or IIa early stomach carcinoma. Comparative studies of the prognosis following limited or radical therapy].
In a retrospective study of 190 patients with type I (n = 100) or type IIa (n = 90) early gastric carcinoma, we investigated the question as to whether after limited therapy--endoscopic polypectomy (n = 49), large forceps biopsy (n = 4) or local surgical excision (n = 14)--or surgical resection (n = 123), differences in prognosis are to be found between the groups. In comparison with the age-adjusted 5-year survival rate, no differences were found between the limited therapy group and the resected group. Postoperative mortality was 3.0% in the limited therapy group and 17.1% in the resected group. Up to the fourth year of follow-up the prognosis was better for malignancy grade 1 than for malignancy grade 2 or 3, and also for tumours with a diameter of less than 3 mm than for those with larger diameters. No difference in 5-year survival rates was to be found with respect to the histological classification, depth of invasion, gross tumour type or multiple tumours. The results of these investigations indicate that limited treatment can be considered for type I or type IIa early gastric carcinoma when the carcinoma is restricted to the mucosa and is of the intestinal cell type of malignancy grade 1 or 2.
Stolte
M
M
Institut für Pathologie, Klinikum Bayreuth.
Schott
R
R
Altendorf-Hofmann
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000379:methods; D016019:Survival Analysis
Magenfrühkarzinom vom Typ I oder IIa. Vergleichende Untersuchungen zur Prognose nach eingeschränkter oder radikaler Therapie.