[A new antianginal preparation: isosorbide-5-mononitrate].
Repeated treadmill exercise tests were used in 20 patients with stable exercise-induced angina in order to comparatively examine various dosage forms of isosorbide-5-mononitrate (IMN) and isosorbide dinitrate (ID) during their single administration. The antianginal effect of conventional IMN tablets (Monisid, Bulgaria) lasted about 5 hours and 1-2 hours longer than that shown by long-acting tablets (Olicard, FRG) and lasted on an average of 12 hours. There was a correlation between the antianginal effect of IMN and its blood concentration. A significant individual variability was observed in the potency of all the dosage forms of IMN and ID under study. The dosage form of IMN had antianginal effects that were similar and even superior to those exhibited by ID.
Martsevich
S Iu
SIu
Metelitsa
V I
VI
Slastnikova
I D
ID
Simkhaev
L S
LS
Egorov
L V
LV
Blagodatskikh
S V
SV
D000787:Angina Pectoris / Q000188:drug therapy*; D002849:Chromatography, Gas; D003692:Delayed-Action Preparations; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D013997:Time Factors
D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Novyĭ antianginal'nyĭ preparat izosorbid-5-mononitrat.