title: Regeneration of retinal axons in grafts of peripheral and central nervous tissue in the adult rat.
abstract: Peripheral nerves were autologously grafted to the retinae of adult rats. The distal end of the nerves was inserted into fetal tectal tissue placed within cortical lesion cavities. Two to 8 months later, anterograde pathway tracing using horseradish peroxidase demonstrated retinal axons regenerating along the length of the PNS nerve graft in 87% of animals with viable PNS and fetal tectal grafts. Of these animals, retinal axons grew into the tectal neuropil in 23% of cases but specific innervation of appropriate target regions was not detected.
authors.affiliation: Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth.
authors.forename: M M
authors.initials: MM
authors.lastname: Tan
authors.forename: A R
authors.initials: AR
authors.lastname: Harvey
authors.forename: K F
authors.initials: KF
authors.lastname: So
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000502:physiology*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000502:physiology*; D051381:Rats; D012160:Retina; D012584:Sciatic Nerve / Q000637:transplantation*; D013477:Superior Colliculi / Q000637:transplantation*; D014182:Transplantation, Autologous
chemical_list: D000110:Acetylcholinesterase