title: [Characteristic CT findings in Krabbe's disease].
abstract: In 12-month-old girl with Krabbe's disease, serial CT and MRI examinations showed characteristic findings, which were symmetric high densities in globus pallidus and thalami before and during the course of brain atrophy and decreased attenuation in white matter. The low densities in white matter were not so remarkable as other degenerative diseases affecting primarily white matter. The high densities in the globus pallidus changed into low densities with progression of the white matter hypodensities and brain atrophy. These findings on CT in Krabbe's disease may assist neurologists in narrowing the differential diagnosis and requesting appropriate laboratory tests.
authors.affiliation: Department of Pediatric Neurology, Gunma Children's Medical Center.
authors.forename: H
authors.initials: H
authors.lastname: Yamanouchi
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D001284:Atrophy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed