Angiotensin II monoclonal antibody: blood pressure effects in normotensive and spontaneously hypertensive rats.
The angiotensin II (AII) specific monoclonal antibody KAA8--a selective functional AII antagonist and a hypotensive agent in high renin hypertensive rats--did not lower blood pressure in conscious normotensive rats (NRs) and spontaneously hypertensive rats (SHRs). The non-peptide AII receptor antagonist DuP 753 decreased blood pressure significantly in SHRs but not in NRs. These results suggest the involvement of locally released AII in the control of blood pressure in SHRs but not in NRs.
Wong
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Medical Products Department, E.I. du Pont de Nemours & Company, Wilmington, DE 19880-0400.
Reilly
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Timmermans
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D000804:Angiotensin II / Q000276:immunology* / Q000502:physiology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D019808:Losartan; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013777:Tetrazoles / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D000959:Antihypertensive Agents; D007093:Imidazoles; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan