[The effect of sclareol lactone and sclareol glycol on artificially induced lung metastases of Lewis lung carcinoma (a preliminary report)].
The prophylactic effect of tetralabdanes, obtained by chemical decomposition of the natural diterpene sclareol (Il. Ognianov and T. Somleva) on the growth of artificially induced lung metastases was studied. After intravenous administration of 25 mg/kg of sclareol-lacton 30 minutes before the transplantation of tumorous cells of Lewis [correction of Luis] lung carcinoma the number of metastases was reduced with 37.5% but in a dose of 50 mg/kg from--33 to 63%. In a dose of 100 mg/kg of sclareol-lacton metastases were increased with 2--7%. Sclareolglycol administered in a dose of 25 mg/kg under the same experimental conditions, reduced lung metastases with 38%, but in a dose of 50 mg/kg--from 26% to 61%. Its administration in a dose of 100 mg/kg stimulated their formation with 62%.
Astardzhieva
Z
Z
Stoichkov
I
I
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000517:prevention & control* / Q000556:secondary*; D004224:Diterpenes / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D004224:Diterpenes; C060464:sclareol glycol
Vliianie na sklareol lakton i sklareol glikol vŭrkhu izkustveno predizvikani belodrobni metastazi na belodrobniia kartsinom na Liuis (predvaritelno sŭobshtenie).