Antineoplastic agents, 195. Isolation and structure of aceratioside from Aceratium megalospermum.
A new tetralin glucoside [1], named aceratioside, has been found to be a weakly cytostatic (PS ED50 9 micrograms/ml) constituent in leaves produced by the Australian rain forest tree Aceratium megalospermum. Structural determination of aceratioside was primarily accomplished with results from a series of acetylation, methylation, and high field nmr (including heteronuclear multiple bond correlation) experiments.
Singh
S B
SB
Cancer Research Institute, Arizona State University, Tempe 85287.
Pettit
G R
GR
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D013764:Tetrahydronaphthalenes; C067645:aceratioside