title: The mechanism of muscle injury in the crush syndrome: ischemic versus pressure-stretch myopathy.
abstract: Crush injuries are ubiquitous, common sequelae in victims of seismic, industrial and military catastrophes, and were considered to be mainly due to ischemia of the affected limbs. Our clinical experience suggests that early in the crush syndrome, interference with the circulation may occur but is rare. The predominant earliest lesion in the crush syndrome is postulated to be pressure-stretch myopathy, rather than ischemic myopathy. It is proposed that at the membrane level, stretch increases sarcoplasmic influx of Na, Cl, H2O and Ca down their electrochemical gradient. Energy-requiring cationic extrusion pumps work at maximal capacity, but are unable to cope with the increased load. This results in cell swelling and increase in cytosolic and mitochondrial calcium with activation of autolytic destructive processes and interference with cellular respiration. Extensive muscle swelling may cause late muscle tamponade and myoneural ischemic damage (compartmental syndrome). Thus, whereas prevalent theory suggests that the sarcolemmal cationic pump activity is attenuated in the crush syndrome due to early ischemia, we propose that the cationic extrusion pump is maximally activated as in the amphotericin B model. Because the cationic pump is maximally activated in the stretched muscle and in cells exposed to amphotericin, these models rapidly deplete their scarce ATP stores and are susceptible to hypoxia in the face of initially normal circulation.
authors.affiliation: Department of Nephrology, Rambam Hospital, Haifa, Israel.
authors.forename: O S
authors.initials: OS
authors.lastname: Better
authors.forename: Z
authors.initials: Z
authors.lastname: Abassi
authors.forename: I
authors.initials: I
authors.lastname: Rubinstein
authors.forename: S
authors.initials: S
authors.lastname: Marom
authors.forename: Y
authors.initials: Y
authors.lastname: Winaver
authors.forename: M
authors.initials: M
authors.lastname: Silberman
mesh_terms: D001693:Biological Transport, Active / Q000502:physiology; D003444:Crush Syndrome / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000503:physiopathology*; D009132:Muscles / Q000098:blood supply*; D012206:Rhabdomyolysis / Q000150:complications / Q000503:physiopathology*