Necessity of IgE antibodies and mast cells for manifestation of resistance against larval Haemaphysalis longicornis ticks in mice.
Genetically mast cell-deficient WBB6F1-W/Wv mice showed an apparent defect in manifestation of the resistance against larval Haemaphysalis longicornis ticks, but their serum IgE levels increased more than 100-fold after the second tick infestation. Immune sera obtained from the WBB6F1-W/Wv mice were adoptively transferred to the other WBB6F1-W/Wv mice which had received intracutaneous injections of WBB6F1-+/+ mouse-derived cultured mast cells. Because the resistance against ticks was detectable only when both mast cells and IgE antibodies were available, immediate hypersensitivity reaction appeared to have a physiologic role in the manifestation of the resistance against H. longicornis ticks.
Matsuda
H
H
Department of Veterinary Surgery, College of Agriculture, University of Osaka Prefecture, Japan.
Watanabe
N
N
Kiso
Y
Y
Hirota
S
S
Ushio
H
H
Kannan
Y
Y
Azuma
M
M
Koyama
H
H
Kitamura
Y
Y
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000276:immunology*; D007814:Larva; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D012867:Skin / Q000276:immunology / Q000473:pathology; D013984:Tick Infestations / Q000276:immunology* / Q000473:pathology; D013987:Ticks / Q000276:immunology
D000906:Antibodies; D007073:Immunoglobulin E