title: Hypertrophic obstructive cardiomyopathy and infective endocarditis: a report of seven cases and a review of the literature.
abstract: Seven cases of infective endocarditis (IE) in patients with hypertrophic obstructive cardiomyopathy (HOCM) are presented in this report. The previous literature is critically reviewed, and the following points are discussed: (a) IE complicates HOCM in 5-9% of cases; (b) anatomical and haemodynamic alterations of HOCM cause microtraumas on heart valves and the endocardium; the resulting endocardial lesions represent sites for bacterial seeding as well as other congenital or acquired heart disease; (c) prognosis is worse in patients with IE associated with HOCM than in patients with IE alone or associated with congenital heart disease; (d) the most frequently isolated organisms are saprophytes; (e) most patients were exposed to bacteraemias before the onset of IE.
authors.affiliation: II Cattedra Malattie Apparato Cardiovascolare, Università La Sapienza, Roma, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Alessandri
authors.forename: G
authors.initials: G
authors.lastname: Pannarale
authors.forename: F
authors.initials: F
authors.lastname: del Monte
authors.forename: F
authors.initials: F
authors.lastname: Moretti
authors.forename: B
authors.initials: B
authors.lastname: Marino
authors.forename: A
authors.initials: A
authors.lastname: Reale
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000000981:diagnostic imaging; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged