[Physiologic model of NY-198 pharmacokinetics using a new method of determining tissue/blood distribution coefficient].
A 10-compartment physiological model of pharmacokinetics of NY-198, a new pyridone carboxylic acid, with antibacterial activity is described. In its construction an original rapid method based on measuring xenobiotic concentration in one particular time point was used for determining the tissue/blood distribution coefficients. The results of simulating the antibiotic pharmacokinetic profiles by the Kd values known from the literature and the values estimated with the proposed method were compared.
Manuĭlov
K K
KK
D042462:4-Quinolones; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D024841:Fluoroquinolones; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism*; D015363:Quinolones; D013997:Time Factors; D014781:Viscera / Q000378:metabolism*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin
Fiziologicheskaia model' farmakokinetiki NY-198 s ispol'zovaniem novogo metoda opredeleniia koeffitsienta raspredeleniia tkan'/krov'.