title: The effects of midazolam on cerebral blood flow and oxygen consumption. Interaction with nitrous oxide in patients undergoing craniotomy for supratentorial cerebral tumours.
abstract: Cerebral blood flow and the cerebral metabolic rate of oxygen were measured in 30 patients during craniotomy for supratentorial cerebral tumours by a modification of the Kety-Schmidt technique using Xenon 133 intravenously. Anaesthesia was induced with midazolam 0.3 mg/kg, fentanyl and pancuronium, and maintained with midazolam as a continuous infusion, fentanyl, pancuronium and nitrous oxide in oxygen or oxygen in air. The concentration of midazolam in the blood of 10 patients was about 300 ng/litre during two measurements; the patients' lungs were ventilated with N2O in oxygen. The concentration of midazolam in the blood of another 10 patients was doubled to about 600 ng/litre during the second flow measurement; the patients' lungs were ventilated with N2O/O2. The concentration of midazolam in the blood of the third group of 10 patients was doubled to 600 ng/litre during the second flow measurement; the patients' lungs were ventilated with oxygen in air. No relationship was found between the dose of midazolam and cerebral blood flow or oxygen consumption. Nitrous oxide in combination with midazolam also had no effect on these variables.
authors.affiliation: Department of Neuroanaesthesiology, University Hospital, Aarhus, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Knudsen
authors.forename: G E
authors.initials: GE
authors.lastname: Cold
authors.forename: H O
authors.initials: HO
authors.lastname: Holdgård
authors.forename: U T
authors.initials: UT
authors.lastname: Johansen
authors.forename: S
authors.initials: S
authors.lastname: Jensen
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001932:Brain Neoplasms / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003399:Craniotomy; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*
chemical_list: D009609:Nitrous Oxide; D008874:Midazolam