title: [Results of the treatment of peripheral arterial diseases with PGE1].
abstract: PGE1 (Prostin VR by Upjohn) was administered in the form of intra-arterial infusion to the patients with ischaemic disease of the limbs. The investigations aimed at collecting additional data contributing to the elaboration of optimal administration of the drug, its dosage and objective assessment of the obtained results. The obtained results have shown that the therapeutic efficiency of PGE1 depends on the advancement of ischaemia. Favourable clinical result was achieved in 45% of the patients manifested by the decrease of pain and healing rate. Such an effect persisted 2-7 months. An increase in serum total proteins and fibrinogen fraction and a decrease in platelet aggregation was seen during the PGE1 infusion. Skin temperature measurements and radioisotope examination with perfusion scintigraphy have shown an increase in blood flow in both muscles and other tissues in the treated patients. The obtained results confirmed a value of intra-arterial PGE1 infusion in the treatment of ischaemic limb diseases.
authors.affiliation: Pracowni Chirurgii Doświadczalnej ICMDiK PAN oraz z II Kliniki Chirurgicznej II Wydziału Lekarskiego AM.
authors.forename: M
authors.initials: M
authors.lastname: Borkowski
authors.forename: M
authors.initials: M
authors.lastname: Kruk
authors.forename: L
authors.initials: L
authors.lastname: Królicki
authors.forename: E
authors.initials: E
authors.lastname: Wojtal
authors.forename: L
authors.initials: L
authors.lastname: Malmurowicz
authors.forename: R
authors.initials: R
authors.lastname: Górewicz
authors.forename: D
authors.initials: D
authors.lastname: Laszuk
mesh_terms: D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage* / Q000627:therapeutic use; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D014654:Vascular Patency / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil
vernacular_title: Ocena wyników leczenia chorób tetnic obwodowych PGE1.