title: Location of a gene conferring DDT resistance but no pyrethroid cross-resistance in larvae of Anopheles stephensi.
abstract: In larvae of Anopheles stephensi, DDT resistance of 30 to 40-fold, involving no cross-resistance to pyrethroids, showed fully dominant monofactorial inheritance. The gene, termed DDT, is located 36.6 cross-over units from the morphological mutant, black larvae (Bl), on chromosome III. A polygenic system, which confers a 17-fold reduction in susceptibility to knockdown by the pyrethroid, permethrin, also makes a minor contribution to DDT resistance. It was not possible to block DDT resistance with the dehydrochlorinase inhibitor DMC.
authors.affiliation: Research Institute ITAL, Wageningen, The Netherlands.
authors.forename: C A
authors.initials: CA
authors.lastname: Malcolm
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics*; D002722:Chlorobenzenes; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003634:DDT; D005796:Genes; D007305:Insecticide Resistance / Q000235:genetics*; D007306:Insecticides; D007814:Larva / Q000235:genetics; D026023:Permethrin; D011722:Pyrethrins
chemical_list: D002722:Chlorobenzenes; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin; D003634:DDT; C004944:chlorfenethol