Diabetic autonomic neuropathy and bladder function: pharmacological use of gangliosides and insulin.
This paper briefly describes experimental evidence indicating that bladder dysfunction observed in diabetic rats is due in part to hyperdiuresis and in part to autonomic nerves alterations. The latter, in analogy with somatic nerves alteration, can be ameliorated by treatment of diabetic animals with gangliosides. The use of this agent in the autonomic nerve dysfunction of diabetic origin is discussed.
Italiano
G
G
Fidia Research Laboratories, Abano Terme, Italy.
Magrì
V
V
Paro
M
M
Prosdocimi
M
M
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005732:Gangliosides / Q000494:pharmacology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D051381:Rats; D001743:Urinary Bladder / Q000294:innervation*; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects
D005732:Gangliosides; D006442:Glycated Hemoglobin; D007328:Insulin