[Antiemetic properties of levo-sulpiride].
Levo-sulpiride is a substituted benzamide with antiemetic activity 3-8 times more potent than the racemic form and the d-isomer. Its mode of action is partially central (inhibition of dopaminergic receptors at the trigger zone for vomiting) and partially peripheral (normalization of motor activity of stomach and gall-bladder). The drug was found effective in the prevention of chemotherapy-induced and post-operative vomiting as well as in the treatment of nausea and vomiting during hepatic, biliary and gastroduodenal disorders, organic and functional dyspepsia, motion sickness and vertigo. Levo-sulpiride is at least as effective as domperidone, antihistamines and neuroleptic agents. Compared with the latter drugs and with d-sulpiride and the racemus, l-sulpiride is much better tolerated. Drowsiness is reported only at high doses, and no clinical signs of hyperprolactinaemia are observed, even after prolonged treatment.
Guslandi
M
M
Istituto di Medicina Interna, Università degli Studi di Milano.
D055598:Chemical Phenomena; D002621:Chemistry; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D009325:Nausea / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy; D013469:Sulpiride / Q000494:pharmacology / Q000627:therapeutic use*; D014717:Vertigo / Q000150:complications; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
D013469:Sulpiride
Proprietà antiemetiche della levo-sulpiride.