[Action of colchicine on analgetic effects of morphine and DADLE in rats].
Intracerebroventricular injection of morphine and DADL significantly increased the tail-flick latency in the rat (full analgesia during 1.5-2.5 hours). Previous i. c. v. (lateral ventriculus) injection of colchicine prevented the analgetic effects of these drugs during 5 +/- 1 weeks with subsequent recovery.
Motin
V G
VG
D000818:Animals; D002552:Cerebral Ventricles; D003078:Colchicine / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D007267:Injections; D008297:Male; D008870:Microtubules / Q000502:physiology; D009020:Morphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D051381:Rats; D011930:Reaction Time; D013997:Time Factors; D014404:Tubulin / Q000502:physiology*
D014404:Tubulin; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine; D003078:Colchicine
Vliianie kolkhitsina na anal'geticheskie éffekty morfina i DADL u krys.