title: [Conservative treatment of acute pancreatitis using intralesional electrophoresis].
abstract: Experimental data are discussed and experience in complex treatment of 102 patients with acute pancreatitis with the application of intralesional+ electrophoresis is analysed. It was demonstrated in experiments on 90 albino rats that in intralesional+ electrophoresis of radioactive++ 5-fluorouracil (5-FU), its concentration in the pancreas was 2.4-3-fold that in the group of animals in which only intraperitoneal injections of the agent were given. Intralesional+ 5-FU, antibiotic, and contrykal electrophoresis was applied in the clinic in 75 patients with edematous and in 27 patients with destructive pancreatitis. Intralesional+ electrophoresis had a favourable effect on the course of acute pancreatitis, but its efficacy was lower in destructive pancreatitis. Intralesional+ electrophoresis made it possible to lower the general therapeutic doses of these agents and to reduce the number of injections per 24 hours. Three fatal outcomes occurred.
authors.forename: V I
authors.initials: VI
authors.lastname: Mironov
authors.forename: A V
authors.initials: AV
authors.lastname: Serkina
authors.forename: L V
authors.initials: LV
authors.lastname: Zabrodina
authors.forename: V V
authors.initials: VV
authors.lastname: Duganova
authors.forename: I E
authors.initials: IE
authors.lastname: Pekerskiĭ
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007478:Iontophoresis / Q000379:methods*; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats
chemical_list: D005472:Fluorouracil
vernacular_title: Konservativnoe lechenie ostrogo pankreatita s primeneniem vnutri- tkanevogo élektroforeza.