In vitro chemosensitivity testing in acute leukemias. Results of a retrospective study.
A retrospective study was carried out on 67 patients with ANLL and ALL to assess the capacity of a rapid in vitro chemosensitivity assay to predict clinical response and patient survival. The test evaluates the extent to which a drug inhibits DNA synthesis by measuring the incorporation of 125Iododeoxyuridine into leukemic cell DNA. Correlations between the in vitro chemosensitivity data and clinical outcome showed that this test predicts the clinical response to remission-inducing drugs with a good level of accuracy (sensitivity = 0.82, specificity = 0.71 but that it is unable to predict length of survival.
Lepri
E
E
Department of Experimental Medicine and Biochemical Sciences, Perugia University, Italy.
Liberati
M
M
Menconi
E
E
Santucci
A
A
Piselli
F
F
Barzi
A
A
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004261:DNA Replication / Q000187:drug effects*; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012189:Retrospective Studies; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
D000970:Antineoplastic Agents