title: T-cell subsets and serum immunoglobulin levels in infants born to HIV-seropositive mothers: a longitudinal evaluation.
abstract: T-lymphocyte subsets and serum immunoglobulins were assayed in 27 neonates and 12 infants younger than 6 months, all born to HIV-seropositive mothers. No differences in T-lymphocyte subsets between the 27 seropositive and 34 seronegative infants were found at birth. Twelve seroreverted and 14 infected children were followed. CD4+ cell counts were significantly lower in the latter at 3 and 24 months of age. Serum immunoglobulin levels and CD8+ percentages became higher in the infected group, starting from the sixth month, while CD4+ percentages and CD4+/CD8+ ratios became lower, starting from the twelfth month.
authors.affiliation: Clinic of Infectious Diseases, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: d'Arminio Monforte
authors.forename: R
authors.initials: R
authors.lastname: Novati
authors.forename: M
authors.initials: M
authors.lastname: Galli
authors.forename: P
authors.initials: P
authors.lastname: Marchisio
authors.forename: E
authors.initials: E
authors.lastname: Massironi
authors.forename: R
authors.initials: R
authors.lastname: Tornaghi
authors.forename: A
authors.initials: A
authors.lastname: Saracco
authors.forename: N
authors.initials: N
authors.lastname: Principi
authors.forename: M
authors.initials: M
authors.lastname: Moroni
mesh_terms: D002675:Child, Preschool; D005260:Female; D006679:HIV Seropositivity / Q000635:transmission*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D015819:Substance Abuse, Intravenous; D016176:T-Lymphocyte Subsets
chemical_list: D007070:Immunoglobulin A; D007075:Immunoglobulin M