Chemical studies on Mexican plants used in traditional medicine, XV. Sesquiterpene evoninoate alkaloids from Hippocratea excelsa.
Three sesquiterpene evoninoate alkaloids, hippocrateine I [1], hippocrateine II [2], and emarginatine A have been isolated from the root and stem barks of Hippocratea excelsa. Compounds 1 and 2 are new naturally occurring substances. The structure of 1 was unequivocally established by X-ray crystallographic analysis, and the structure of the second new alkaloid was deduced by spectral analysis.
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División de Bioquímica y Farmacia, Facultad de Química, Ciudad Universitaria, México D.F.
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D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D008800:Mexico; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C064682:emarginatine A; C067646:hippocrateine I; C067647:hippocrateine II