title: Acute renal failure following collective intoxication by Cortinarius orellanus.
abstract: Twenty-six young men with no previous medical history all ingested mushroom soup, exclusively made with Cortinarius orellanus. They were hospitalized 10-12 days after the incident. On admission, 12 patients presented with acute tubulointerstitial nephritis with acute renal failure; 8 required haemodialysis. In addition to symptomatic treatment, 9 patients were given corticosteroids. In this group of 12 patients, 8 recovered rapidly, and the other 4 suffered from chronic renal failure for several months. In the other group of 14 patients, initial leukocyturia was observed in 12 cases, although renal function remained normal during a one-year follow-up. Hepatic acetylation and hydroxylation tests performed after 6 months in 22 patients did not provide any explanation for the strong individual sensitivity to the renal toxicity of this fungus.
authors.affiliation: Casualty and Medical Emergency Unit, Hôpital Pontchaillou, Rennes, France.
authors.forename: J
authors.initials: J
authors.lastname: Bouget
authors.forename: J
authors.initials: J
authors.lastname: Bousser
authors.forename: B
authors.initials: B
authors.lastname: Pats
authors.forename: M P
authors.initials: MP
authors.lastname: Ramee
authors.forename: D
authors.initials: D
authors.lastname: Chevet
authors.forename: G
authors.initials: G
authors.lastname: Rifle
authors.forename: C P
authors.initials: CP
authors.lastname: Giudicelli
authors.forename: R
authors.initials: R
authors.lastname: Thomas
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000363:Agaricales; D004196:Disease Outbreaks; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008889:Military Personnel; D009145:Mushroom Poisoning / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D006435:Renal Dialysis
chemical_list: D000305:Adrenal Cortex Hormones