[Megaloblastic pancytopenia in a female patient with rheumatoid arthritis given methotrexate and amidopyrine simultaneously].
The paper is concerned with the development of megaloblastic pancytopenia in a female patient with grave rheumatoid arthritis. The patient had been given methotrexate (15 mg per week) for a long time, supplemented by amidopyrine (1.0 to 1.5 g/day). The author holds that the development of the above-indicated complication is provoked by both drugs interference into folate metabolism. It is concluded that caution should be taken as to the combined use of methotrexate with non-narcotic analgesic drugs, nonsteroidal anti-inflammatory agents and sulfanilamides.
Noskov
S M
SM
D000208:Acute Disease; D000632:Aminopyrine / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008534:Megaloblasts / Q000187:drug effects*; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D010198:Pancytopenia / Q000097:blood / Q000139:chemically induced*
D000632:Aminopyrine; D008727:Methotrexate
Megaloblasticheskaia pantsitopeniia u bol'noĭ revmatoidnym artritom pri odnovremennom primeneniem metotreksata i amidopirina.