title: [Changes in radiosensitivity of chromosomes at the presynthetic stage of the mitotic cycle: role of single-stranded segments of DNA].
abstract: Formation of single-stranded DNA regions was investigated during the presynthetic stage of human lymphocyte cell cycle. Two peaks of single-stranded region production were found in about the middle and near the end of the G1 stage. Both the peaks appeared some hours earlier in gamma-irradiated cells than in control. Experiments showed that the periods of the peak formation coincided with the terms when time-effect dependence for gamma-induced chromosomal aberrations changed its character. The interpretation of the results supposes existence of inherent for the G1 stage process of genetic material correction.
authors.forename: T V
authors.initials: TV
authors.lastname: Kondrashova
authors.forename: N V
authors.initials: NV
authors.lastname: Luchnik
mesh_terms: D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000235:genetics*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007399:Interphase; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology
chemical_list: D004277:DNA, Single-Stranded; D010835:Phytohemagglutinins
vernacular_title: Izmeneniia radiochuvstvitel'nosti khromosom na predsinteticheskoĭ stadii mitoticheskogo tsikla: rol' odnonitevykh uchastkov DNK.