Perinatal outcome associated with PCP versus cocaine use.
Phencyclidine (PCP) remains a widely used illicit drug, especially among adolescents and young adults. The pharmacologic effects of PCP are similar to those of cocaine; therefore, in this retrospective study 37 PCP-intoxicated parturients were matched for ethnicity, tobacco use, age, gravidity, and degree of prenatal care with 37 cocaine-intoxicated parturients. Infants exposed to PCP in utero, like those exposed to cocaine, had a high incidence of intrauterine growth retardation (32 vs 19%, N.S.), precipitate labor (43 vs 27%, N.S.), symptoms of neonatal drug withdrawal/intoxication, and prolonged neonatal hospitalizations. Moreover, they were more likely to have meconium-stained amniotic fluid (30 vs 19%, p = .05) and less likely to be born prematurely as cocaine-exposed infants. The comparison between the long-term developmental outcome of these groups awaits further study.
Tabor
B L
BL
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance 90509.
Smith-Wallace
T
T
Yonekura
M L
ML
D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D009357:Neonatal Abstinence Syndrome / Q000175:diagnosis*; D007752:Obstetric Labor, Premature / Q000139:chemically induced; D010622:Phencyclidine / Q000009:adverse effects*; D010623:Phencyclidine Abuse / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000175:diagnosis*
D003042:Cocaine; D010622:Phencyclidine