title: A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis.
abstract: During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: S F
authors.initials: SF
authors.lastname: Yu
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Uno
authors.forename: K
authors.initials: K
authors.lastname: Terao
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000737:chemistry / Q000633:toxicity; D002849:Chromatography, Gas; D006801:Humans; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D009615:Nocardia / Q000145:classification / Q000378:metabolism*; D009617:Nocardia Infections / Q000382:microbiology*; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D014407:Tumor Cells, Cultured
chemical_list: D001427:Bacterial Toxins