title: Urinary neopterin excretion in patients with uterine sarcomas.
abstract: Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell-mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was significantly higher (P less than 0.0001) than that obtained in women with benign myomas and healthy controls. Furthermore, a significant correlation of normal or raised neopterin concentrations with the clinical course of disease was found. These data suggest that urinary neopterin measurement might be a useful immunologic marker for women with uterine sarcomas.
authors.affiliation: Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
authors.forename: L C
authors.initials: LC
authors.lastname: Fuith
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: A
authors.initials: A
authors.lastname: Hausen
authors.forename: H
authors.initials: H
authors.lastname: Hetzel
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: E R
authors.initials: ER
authors.lastname: Werner
authors.forename: H
authors.initials: H
authors.lastname: Wachter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D019798:Neopterin; D012509:Sarcoma / Q000473:pathology / Q000652:urine*; D014594:Uterine Neoplasms / Q000473:pathology / Q000652:urine*
chemical_list: D001708:Biopterins; D019798:Neopterin