title: [Pharmacodynamics of antibiotics in their preventive use in heart surgery with general artificial circulation].
abstract: Pharmacodynamics of antibiotics in their prophylactic use was studied in 100 operations with artificial circulation, which were performed in patients with rheumatic heart defects. It was established that at the time of operation and after it, the antibiotic excreted via the kidneys insignificantly++, within the whole period of intracardiac stage of the operation, the myocardium remained without the antibacterial protection, and required the local use of an antibiotic.
authors.forename: O A
authors.initials: OA
authors.lastname: Krastin
authors.forename: L E
authors.initials: LE
authors.lastname: Grabar
authors.forename: V A
authors.initials: VA
authors.lastname: Korchagin
authors.forename: N V
authors.initials: NV
authors.lastname: Chagorov
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control*; D002439:Cefotaxime / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005112:Extracorporeal Circulation; D006801:Humans; D007275:Injections, Intravenous; D007430:Intraoperative Care; D011300:Preoperative Care; D012214:Rheumatic Heart Disease / Q000378:metabolism / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002439:Cefotaxime
vernacular_title: Farmakodinamika antibiotikov pri ikh profilakticheskom primenenii u bol'nykh, operirovannykh na serdtse v usloviiakh obshchego uskusstvennogo krovoobrashcheniia.