title: Acute necrotizing esophagitis.
abstract: Esophagitis of varying degrees and significance is caused by reflux, infections, radiation, and ingestion of chemical agents. A case of necrotizing esophagitis, seen as a black esophagus on endoscopy in a postoperative patient and resulting in long tubular stricture which ultimately required esophagectomy, is reported. Although the course of necrotizing esophagitis may parallel that associated with ischemia, severe caustic injury, or overwhelming infection, its etiology is uncertain. Diminished mucosal defenses, microbial implantation by a nasogastric tube placed perioperatively or sepsis, and transient ischemia with oxyradical formation and resultant reperfusion injury are hypothesized as important causative factors in the pathogenesis of acute necrotizing esophagitis.
authors.affiliation: Department of Medicine, Griffin Hospital, Derby, Connecticut.
authors.forename: S P
authors.initials: SP
authors.lastname: Goldenberg
authors.forename: S L
authors.initials: SL
authors.lastname: Wain
authors.forename: P
authors.initials: P
authors.lastname: Marignani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004940:Esophageal Stenosis / Q000209:etiology; D004941:Esophagitis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D004947:Esophagus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009336:Necrosis