title: Effect of calcitonin on total body bone mineral contents of experimental osteoporotic rats determined by dual photon absorptiometry.
abstract: Total body bone mineral (TBBM) content in rats was measured by dual photon absorptiometry (DPA). TBBM showed significant increases over 4 weeks in control groups with significant bone loss over the same time in prednisolone-injected rats on low calcium feed. Daily injections of calcitonin significantly reduced loss of bone mass. Both prednisolone- and prednisolone-calcitonin-injected groups showed significantly elevated serum alkaline phosphatase with the prednisolone-calcitonin group also exhibiting elevated serum calcium and phosphate levels, confirming the impact of the experimental protocol. TBBM measured by DPA in all groups correlated well (r = 0.928, P less than 0.001 n = 20) with the total ash weight suggesting that the method reflects total skeletal mineral content in the small animal. TBBM measurement by DPA proves well-suited to monitoring bone mineral in a small animal experimental setting.
authors.affiliation: Second Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: H
authors.initials: H
authors.lastname: Ochi
authors.forename: H
authors.initials: H
authors.lastname: Morii
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000737:chemistry / Q000378:metabolism; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D005260:Female; D007273:Injections, Intramuscular; D008903:Minerals / Q000032:analysis / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism*; D010710:Phosphates / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008903:Minerals; D010710:Phosphates; D002116:Calcitonin; D011239:Prednisolone; D002118:Calcium