The effect of moderate hemodilution with fluosol-DA or normal saline on acetaminophen disposition in the rat.
Hemodilution with 40 ml/kg of Fluosol or saline reduced the acetaminophen Vd and the acetaminophen sulfate ClM at 48 or 72 h, respectively. Fluosol hemodilution increased the acetaminophen renal excretion at 24 and 72 h. But at 48 h, Fluosol hemodilution either inhibited the renal secretion of acetaminophen or enhanced its reabsorption.
Shrewsbury
R P
RP
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
White
L G
LG
D000082:Acetaminophen / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004338:Drug Combinations; D005466:Fluorocarbons; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives; D007668:Kidney / Q000378:metabolism; D008297:Male; D010952:Plasma Substitutes; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D000082:Acetaminophen; D012965:Sodium Chloride; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D003577:Cytochrome P-450 Enzyme System