title: [Effect of a synthetic somatostatin analogue with delayed action (SMS 201-995) on the biliary expenditure in a patient with an external biliary tract fistula].
abstract: The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.
authors.affiliation: Unidad de Investigación de Endocrinología, IMSS, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: Miranda-Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Castañón-González
authors.forename: C
authors.initials: C
authors.lastname: Pérez Aldana
authors.forename: E
authors.initials: E
authors.lastname: Arias
authors.forename: M
authors.initials: M
authors.lastname: Díaz de León Ponce
authors.forename: A
authors.initials: A
authors.lastname: Zárate
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism*; D001658:Biliary Fistula / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D005402:Fistula / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D003692:Delayed-Action Preparations; D015282:Octreotide
vernacular_title: Efecto de un análogo sintético de somatostatina de acción prolongada (SMS 201-995) sobre el gasto biliar en un paciente con una fístula externa de las vías biliares.