Effect of fusidic acid on migration and chemiluminescence of polymorphonuclear leukocytes.
Incubation of polymorphonuclear leukocytes (PMNs) in fusidic acid resulted in a decrease of random migration and chemiluminescence. The effects were dose-dependent but moderate, with statistical significance only at concentrations of 50 mg/l or more. At concentrations used for therapy of bacterial infections and AIDS, fusidic acid was not shown to be deleterious to these aspects of PMN function.
Naess
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A
Medical Department B, Haukeland Hospital, University of Bergen, Norway.
Flø
R W
RW
Solberg
C O
CO
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D002465:Cell Movement / Q000187:drug effects; D005672:Fusidic Acid / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects
D005672:Fusidic Acid