[Subacute cutaneous lupus erythematosus. Review of the literature and immunological studies of 11 patients].
Following a broad review of the literature referring to the histopathological clinical, immunological and immunogenetic characteristics of a particular variety of recently identified cutaneous lupus erythematosus, namely subacute lupus erythematous, the results of immunopathological studies in 11 patients (6 of whom presented the ring polycyclic variety and 5 the psoriasiform variety) are reported. Serum and skin samples were compared in both varieties and it was noted that there is: 1) a more marked incidence of hypocomplementemia and the presence of immune circulating complexes in the ring-polycyclic variety; 2) a more frequent demonstration of IgG and C at the dermo-epidermic junction and on the edge of superficial derma vessels in the same variety. These findings are interpreted as being the consequence of a more frequent and severe systemic (and above all renal) impairment in the ring-polycyclic variety.
Fabbri
P
P
Istituto di Clinica Dermatologica, Università di Sassari.
Bernacchi
E
E
Neri
R
R
D000328:Adult; D000936:Antigen-Antibody Complex; D003165:Complement System Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D003165:Complement System Proteins
Lupus eritematoso cutaneo subacuto. Rassegna della letteratura e ricerche immunologiche su 11 pazienti.