title: Fibrovascular response to retinal tacks in the rabbit and monkey eye.
abstract: In order to evaluate the tissue response to metal retinal tacks experiments were carried out on 4 monkey eyes and compared to those on 4 rabbits. Non-magnetic retinal tacks (Grieshaber, Switzerland) and tacks made of 24 carat gold (our own brand) were inserted into the ocular fundus under microscopic control. The animals were kept for 3 months. In monkey eyes, histological examination disclosed a considerable fibrovascular proliferation around the retinal tack canal, including an inflammatory response, formation of collagenous tissue and glial proliferation. There was a local intra-retinal and epi-retinal neovascularization. In the rabbit retina, only a slight inflammation and thin collagenous tissue developed. Thus the tissue response was much more severe in the primate eye than in the avascular rabbit retina.
authors.affiliation: Department of Ophthalmology, Karolinska Institute and Hospital, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Algvere
authors.forename: P
authors.initials: P
authors.lastname: Jahnberg
mesh_terms: D000818:Animals; D005355:Fibrosis; D006046:Gold; D007249:Inflammation / Q000473:pathology; D008252:Macaca fascicularis; D008422:Materials Testing; D019736:Prostheses and Implants; D011817:Rabbits; D012160:Retina / Q000473:pathology / Q000601:surgery*; D015861:Retinal Neovascularization / Q000209:etiology / Q000473:pathology*
chemical_list: D006046:Gold