title: [Adjuvant chemotherapy of osteosarcoma].
abstract: Osteosarcoma is the one of the tumors that's prognosis have been improved dramatically by the introduction of chemotherapy consisting mainly of adriamycin, high-dose methotrexate with Leucovorin rescue and cisplatinum. Now, the purpose of the treatment for osteosarcoma are assurance of their life and functional and beautiful limb-sparing. Recently, preoperative chemotherapy for limb saving is given to patients with osteosarcoma of the extremities. The five year survival rate increased to 65% and limb sparing rate became above 50%. It is generally accepted that pre- and post-operative chemotherapy can inhibit pulmonary micro metastasis and prove to be of great significance in improving the survival rate of patients with osteosarcoma of extremities and achieve limb salvage operation.
authors.affiliation: Dept of Orthop, National Sapporo Hospital Hokkaido Cancer Center.
authors.forename: S
authors.initials: S
authors.lastname: Yamawaki
authors.forename: K
authors.initials: K
authors.lastname: Isu
authors.forename: Y
authors.initials: Y
authors.lastname: Ubayama
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: M
authors.initials: M
authors.lastname: Usui
authors.forename: S
authors.initials: S
authors.lastname: Isii
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D012516:Osteosarcoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate