Comparative morphometric analysis of aggressive and ordinary basal cell carcinoma of the skin.
A morphometric analysis was performed on histologic sections of 11 cases of aggressive basal cell carcinoma that recurred and/or metastasized after the first diagnosis (BCC2) and on 11 ordinary basal cell carcinomas (BCC1). The considered parameters were as follows: nuclear area, perimeter, maximum diameter, feret x, feret y, form perimeter, and form area. The results show numeric differences between the two groups for the first five parameters. A statistical analysis was performed between BCC1 and BCC2 for all the considered parameters using a two-sided t test for independent samples. The test showed significant differences between the first five parameters except for the two form factors. A multivariate analysis was performed using area and perimeter values of the compared groups that amplified the discrimination threshold between the two groups. The authors conclude that a morphometric assessment may bring significant contribution in the knowledge and in the outcome prediction of basal cell carcinoma.
de Rosa
G
G
Surgical Pathology Service, II Faculty of Medicine and Surgery, Naples, Italy.
Vetrani
A
A
Zeppa
P
P
Zabatta
A
A
Barra
E
E
Gentile
R
R
Fulciniti
F
F
Troncone
G
G
di Benedetto
G
G
Palombini
L
L
D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*