Increased oxygen radical production determined by whole blood chemiluminescence in patients with previous Yersinia arthritis.
Luminol-dependent whole blood chemiluminescence (CL) was studied in patients with previous yersinia arthritis (YA). Patients showed significantly higher CL responses compared to healthy controls regardless of HLA-B27 antigen when either N-formyl-methionyl-leucyl-phenylalanine or opsonized zymosan particles were used a stimulus. This hyperreactivity may well play a role in the development of inflammatory injury in YA.
Ristola
M
M
Department of Bacteriology and Immunology, University of Helsinki, Finland.
D000328:Adult; D000368:Aged; D001170:Arthritis, Infectious / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D015009:Yersinia Infections / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D015054:Zymosan / Q000494:pharmacology
D005609:Free Radicals; D015796:HLA-B27 Antigen; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan; D010100:Oxygen