[Cholestatic hepatitis induced by the amoxicillin-clavulanic acid combination. A case and review of the literature].
We report the case of a patient who developed jaundice after receiving amoxicillin-clavulanic acid for 7 days. Laboratory features were consistent with acute cholestatic hepatitis. Histopathological examination of a liver specimen showed cholestasis. Complete recovery occurred within 2 months after withdrawal of the drug. Analysis of the 24 reported cases of amoxicillin-clavulanic acid induced hepatitis revealed a predominantly cholestatic syndrome occurring soon after drug administration. In all cases, hepatic dysfunction disappeared within 1 to 3 months after discontinuation of the drug. Because of the small number of cases in contrast with the widespread use of this drug, associated with blood hypereosinophilia or eosinophilic infiltration of portal triads in some cases, a hypersensitivity phenomenon is suggested.
Cleau
D
D
Service de Médecine B, Centre Hospitalier Général-Paul-Morel, Vesoul.
Jobard
J M
JM
Alves
T
T
Gury
S
S
Rey
B
B
Vuillemard
M
M
Noirot
A
A
Floriot
C
C
Wagschal
G
G
Vieille
J
J
D000658:Amoxicillin / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D002779:Cholestasis / Q000139:chemically induced* / Q000209:etiology; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000658:Amoxicillin
Hépatite cholestatique due à l'association amoxicilline-acide clavulanique. Un cas et revue de la littérature.