title: Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract.
abstract: It is conceivable that drugs with anticataract potential possess antioxidant activity. Using defined chelating agents and reducing agents in a number of assays for antioxidant activity, we have demonstrated that paracetamol, aspirin, bendazac, and its metabolite 5-hydroxybendazac possess substantial reducing and/or metal-chelating activity. We found that paracetamol and 5-hydroxybendazac reduced the diphenylpicrylhydrazyl free radical; inhibited butyl peroxide-induced erythrocyte lysis as well as the haematin-catalyzed oxidative coupling of 4-aminoantipyrine and phenol by butyl peroxide. Furthermore, paracetamol, bendazac, and aspirin competed with 3-(2-pyridyl)-5,6-Diphenyl-1,2,4-triazine-4', 4"-disulphonic acid (ferrozine) for ferrous ion.
authors.affiliation: Department of Clinical Pharmacology, University College London, U.K.
authors.forename: A C
authors.initials: AC
authors.lastname: Woollard
authors.forename: S P
authors.initials: SP
authors.lastname: Wolff
authors.forename: Z A
authors.initials: ZA
authors.lastname: Bascal
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D000675:Ampyrone / Q000378:metabolism; D000975:Antioxidants / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002386:Cataract / Q000188:drug therapy*; D002614:Chelating Agents / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005609:Free Radicals; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000378:metabolism*; D007191:Indazoles / Q000494:pharmacology*; D019800:Phenol; D010636:Phenols / Q000378:metabolism; D010851:Picrates
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002614:Chelating Agents; D005609:Free Radicals; D006834:Hydrazines; D007191:Indazoles; D010636:Phenols; D010851:Picrates; D000675:Ampyrone; D019800:Phenol; D000082:Acetaminophen; D006427:Hemin; C051605:5-hydroxybendazac; C004931:1,1-diphenyl-2-picrylhydrazyl; C000123:bendazac; D001241:Aspirin