title: Non-CS pre-erythrocytic protective antigens.
abstract: Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro.
authors.affiliation: Biomedical Research Institute, Rockville, MD 20852.
authors.forename: M R
authors.initials: MR
authors.lastname: Hollingdale
authors.forename: M
authors.initials: M
authors.lastname: Aikawa
authors.forename: C T
authors.initials: CT
authors.lastname: Atkinson
authors.forename: W R
authors.initials: WR
authors.lastname: Ballou
authors.forename: G X
authors.initials: GX
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
authors.forename: B
authors.initials: B
authors.lastname: Sina
authors.forename: C
authors.initials: C
authors.lastname: Wright
authors.forename: J D
authors.initials: JD
authors.lastname: Zhu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology / Q000302:isolation & purification*; D008099:Liver / Q000469:parasitology; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology
chemical_list: D000953:Antigens, Protozoan; D010446:Peptide Fragments; D015800:Protozoan Proteins; C067302:liver stage-specific antigen, Plasmodium