[Synthesis of N-(2-mercaptopyridyl-3-formyl)-N-alkyl glycine and the corresponding disulfides].
N-(2-mercaptopyridyl-3-formyl)-N-alkyl glycine I1-8) were synthesized by the condensation of 2-mercaptopyridyl-3-formyl chloride with ethyl N-alkyl glycinate followed by hydrolysis. The corresponding disulfides (II1-7) were obtained by the oxidation of compounds I1-7 with hydrogen peroxide (1%) in weak alkali medium below 10 degrees C. In preliminary tests, some compounds showed inhibitory activity of ACE in vitro.
Luo
Y L
YL
Division of Medicinal Chemistry, China Pharmaceutical University, Nanjing.
Yang
Z X
ZX
Peng
S X
SX
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011725:Pyridines / Q000138:chemical synthesis*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011725:Pyridines; D005998:Glycine