title: Cellular and humoral autoimmune responses against human eye muscle membrane antigen in Graves' disease.
abstract: 75 patients with Graves' disease (54 with ophthalmopathy) were investigated using the tests of leucocyte adherence inhibition and immune adsorption with 125I-labelled Staphylococcus Protein A, against human eye muscle "crude" membrane antigen. The results of positive leucocyte adherence inhibition (10 out of 26 vs. 1 out of 28, P less than 0.05) and anti-human eye muscle membrane antibody index (mean +/- S.D.) (1.89 +/- 1.20 vs. 0.84 +/- 0.38, P less than 0.001) showed a correlation with the patients with clinically active eye disease and the HLA-B8 antigen in Graves' ophthalmopathy (P less than 0.01). Positive leucocyte adherence inhibition was observed in 9 out of 21 cases of Graves' disease without ophthalmopathy, but its prognostic relevance has to be confirmed in the development of ophthalmopathy.
authors.affiliation: 3rd Department of Medicine, Kenezy's Hospital, Debrecen, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Molnár
authors.forename: K
authors.initials: K
authors.lastname: Németi
authors.forename: A
authors.initials: A
authors.lastname: Bokk
authors.forename: V
authors.initials: V
authors.lastname: Stenszky
authors.forename: C
authors.initials: C
authors.lastname: Balázs
authors.forename: N R
authors.initials: NR
authors.lastname: Farid
mesh_terms: D000917:Antibody Formation; D000954:Antigens, Surface / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000276:immunology*; D011379:Prognosis
chemical_list: D000954:Antigens, Surface; D001323:Autoantibodies