A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.
Moser
A R
AR
McArdle Laboratory for Cancer Research, University of Wisconsin-Madison 53706.
Pitot
H C
HC
Dove
W F
WF
D000236:Adenoma / Q000150:complications / Q000235:genetics*; D000483:Alleles; D000740:Anemia / Q000150:complications / Q000235:genetics; D000818:Animals; D005038:Ethylnitrosourea; D005260:Female; D007414:Intestinal Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation
D005038:Ethylnitrosourea