Inotropic activities of imidazopyridines.
A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.
Barraclough
P
P
Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Black
J W
JW
Cambridge
D
D
Gerskowitch
V P
VP
Hull
R A
RA
Lyer
R
R
King
W R
WR
Kneen
C O
CO
Nobbs
M S
MS
Shah
G P
GP
D000758:Anesthesia; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002316:Cardiotonic Agents; D007093:Imidazoles; D011725:Pyridines