title: The distribution of the Hb constant spring gene in Southeast Asian populations.
abstract: The distribution of the hemoglobin Constant Spring (Hb CS) gene in eight populations in Southeast Asia (including Assam) was determined using oligonucleotide hybridization. Hb CS was absent in two Assamese populations with a high prevalence of Hb E. The Hb CS gene frequency was 0.033 in northern Thailand and near 0.01 in central Thailand and Cambodia. High frequencies, between 0.05 and 0.06, were observed in northeastern Thailand. The present data and a similar study in Laotians suggest that the Lao-speaking populations of the Mekong River basin in northeastern Thailand and Laos have the highest frequencies of the Hb CS gene in Southeast Asia.
authors.affiliation: Abteilung Humangenetik, Medizinische Hochschule, Hannover, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Laig
authors.forename: M
authors.initials: M
authors.lastname: Pape
authors.forename: J
authors.initials: J
authors.lastname: Hundrieser
authors.forename: G
authors.initials: G
authors.lastname: Flatz
authors.forename: T
authors.initials: T
authors.lastname: Sanguansermsri
authors.forename: B M
authors.initials: BM
authors.lastname: Das
authors.forename: R
authors.initials: R
authors.lastname: Deka
authors.forename: P
authors.initials: P
authors.lastname: Yongvanit
authors.forename: N
authors.initials: N
authors.lastname: Mularlee
mesh_terms: D001210:Asia, Southeastern; D005787:Gene Frequency; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D009154:Mutation
chemical_list: D006455:Hemoglobins, Abnormal; C035541:Hemoglobin Constant Spring