title: Localization of inflammation with 111In IgG and 99Tcm albumin colloid labelled leukocytes in a rabbit model.
abstract: Localization of inflammation with two recently described radiotracers, 111In-labelled polyclonal IgG and 99Tcm albumin colloid labelled leukocytes (Tc-WBC), was studied. Accumulation of activity was compared with 111In-labelled leukocytes (In-WBC) using 131I human serum albumin as a control. Ratios of activity in a chemically induced abscess in the thigh of rabbits compared with normal muscle tissue were measured. The results showed that all agents localize in inflammation but Tc-WBC consistently localizes to a greater degree than the other agents. At 2 h the inflammed-to-normal ratios for Tc-WBC were 4, IgG 2.1, albumin 1.9 and In-WBC 1.7. The pattern of the ratios remained similar over the 18 h period of the study. The short time in which leukocytes can be labelled and the quality of the images obtained suggest that Tc-WBC imaging is the method of choice for this model.
authors.affiliation: Division of Nuclear Medicine, University of Washington School of Medicine, Seattle 98195.
authors.forename: H B
authors.initials: HB
authors.lastname: Breitz
authors.forename: H I
authors.initials: HI
authors.lastname: Modell
authors.forename: M M
authors.initials: MM
authors.lastname: Graham
mesh_terms: D000818:Animals; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D007249:Inflammation / Q000000981:diagnostic imaging*; D007962:Leukocytes; D011817:Rabbits; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin