title: Cerebral hemodynamics in patients with chronic obstructive carotid disease by rCBF, rCBV, and rCBV/rCBF ratio using SPECT.
abstract: To evaluate cerebral hemodynamics, 21 patients with chronic occlusion or severe stenosis of the internal carotid or middle cerebral artery with normal or only lacunar infarction on x-ray CT were studied using single photon emission computed tomography (SPECT). We measured rCBV with 99mTc erythrocytes after rCBF with 133Xe, and calculated rCBV/rCBF. rCBF and rCBV of the 25 affected hemispheres were classified as (a) patients with normal rCBF [type I (n = 7) and type II (n = 3)]; (b) patients with decreased rCBF [type III (n = 6) and type IV (n = 9)]. These two groups then could be subdivided according to findings of rCBV, normal, and increased blood volumes. rCBV/rCBF increased as the cerebral perfusion pressure dropped from type I to type III. In type IV, other situations but cerebral autoregulation could be assumed. rCBV/rCBF signifies vascular mean transit time. Type III (high rCBV/rCBF) assumed as the increased OEF, misery perfusion as reported in PET. We propose rCBF, rCBV and rCBV/rCBF using SPECT can be an index for cerebral circulatory reserve.
authors.affiliation: Department of Radiology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Toyama
authors.forename: G
authors.initials: G
authors.lastname: Takeshita
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Anno
authors.forename: K
authors.initials: K
authors.lastname: Ejiri
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Katada
authors.forename: S
authors.initials: S
authors.lastname: Koga
authors.forename: N
authors.initials: N
authors.lastname: Ishiyama
authors.forename: T
authors.initials: T
authors.lastname: Kanno
mesh_terms: D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D002343:Carotid Artery, Internal; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D013667:Technetium