[Changes in the rate of protein synthesis in parenchymatous liver cells during stimulation of the mononuclear phagocyte system].
In vivo stimulation of mononuclear phagocyte system (MPS) by zymosan, dextrane sulfate, and prodigiosan caused almost a two-fold increase in hepatic protein synthesis. The rate of 14C-leucine incorporation increased both into total and soluble proteins. To define the cellular locus of these changes, preparations of hepatic parenchymal and nonparenchymal cells were obtained from the control and LPS-stimulated rats. The results indicate that the treatment of rats with prodigiosan stimulate protein synthesis in hepatocytes. No effect on protein synthesis of non-parenchymal cells was observed. Stimulation of MPS also caused a significant increase in 14C-leucine incorporation into serum lipoproteins. The results suggest that MPS may be involved in regulation of protein synthesis in hepatic parenchymal cells.
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D000818:Animals; D002250:Carbon Radioisotopes; D002478:Cells, Cultured / Q000378:metabolism; D016264:Dextran Sulfate / Q000494:pharmacology; D005260:Female; D007930:Leucine / Q000097:blood / Q000187:drug effects; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010586:Phagocytes / Q000187:drug effects*; D011354:Prodigiozan / Q000494:pharmacology; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D015054:Zymosan / Q000494:pharmacology
D002250:Carbon Radioisotopes; D008074:Lipoproteins; D011506:Proteins; D015054:Zymosan; D016264:Dextran Sulfate; D011354:Prodigiozan; D007930:Leucine
Izmenenie skorosti sinteza belka v parenkhimnykh kletkakh pecheni pri stimuliatsii sistemy mononuklearnykh fagotsitov.