Technique and preliminary results of extracorporeal liver surgery (bench procedure) and of surgery on the in situ perfused liver.
The clinical experience with 11 patients undergoing ex situ operation of the liver (nine operations) or surgery on an in situ hypothermic perfused liver after vascular isolation (three operations) is described. These methods have been confined to situations and tumour stages otherwise deemed untreatable, or to situations where resection would not have been sufficiently radical. In one patient the ex situ approach avoided the need to undertake liver grafting for a benign tumour. To date, hepatocellular tumours and metastases not compromising global hepatic function or causing cholestasis are considered to be suitable conditions; cholestasis appears to be highly detrimental for the postoperative course after an ex situ procedure. Elaboration of methods for better grading of pre-existing liver damage and of its prognostic significance is essential. The assessment of the final therapeutic value of the described procedure requires further experience.
Pichlmayr
R
R
Klinik für Abdominal- und Transplantationschirurgie, Medizinischen Hochschule, Hannover, FRG.
Grosse
H
H
Hauss
J
J
Gubernatis
G
G
Lamesch
P
P
Bretschneider
H J
HJ
D000328:Adult; D005112:Extracorporeal Circulation; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D007036:Hypothermia, Induced; D007431:Intraoperative Complications; D008099:Liver / Q000601:surgery*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D010477:Perfusion