Inhibitory effects of snuff extract on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in relation to cell proliferation of mouse tongue epithelial cells.
Effect of snuff extract (SE) on cell proliferation as measured by 3H thymidine (TdR) uptake, induction of ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) was studied in primary embryonal mouse tongue cultures. Cultures treated with SE in combination with 7,12-dimethylbenz(a)anthracene (DMBA) showed inhibition of cell proliferation and decrease of ODC and AHH activities, compared to control, DMBA, and DMBA + 12-O-tetradecanoylphorbol 13-acetate treated cultures.
Gijare
P S
PS
Carcinogenesis Division, Tata Memorial Centre, Bombay, India.
Rao
K V
KV
Bhide
S V
SV
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors; D002273:Carcinogens; D002455:Cell Division; D002478:Cells, Cultured; D009062:Mouth Neoplasms / Q000209:etiology*; D065108:Ornithine Decarboxylase Inhibitors; D010947:Plants, Toxic; D014030:Tobacco, Smokeless / Q000633:toxicity*; D014059:Tongue / Q000166:cytology / Q000201:enzymology
D002273:Carcinogens; D065108:Ornithine Decarboxylase Inhibitors; D001189:Aryl Hydrocarbon Hydroxylases