Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine.
The pharmacokinetics of nifedipine and its primary oxidised metabolite, M-I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co-trimoxazole. Following pretreatment with co-trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half-life, or area under the plasma concentration-time curve of either nifedipine or M-I, nor on the blood pressure response to nifedipine.
Edwards
C
C
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.
Monkman
S
S
Cholerton
S
S
Rawlins
M D
MD
Idle
J R
JR
Ferner
R E
RE
D000328:Adult; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics*; D011292:Premedication; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009543:Nifedipine