D-penicillamine does not increase urinary bismuth excretion in patients treated with tripotassium dicitrato bismuthate.
Twenty-four urinary bismuth excretion was measured in five patients who had been treated with tripotassium dicitrato bismuthate, before and after single 1 g oral dose of D-penicillamine. Before dosing with D-penicillamine, the median 24 h urinary bismuth output was 55 micrograms 24 h-1 (range 17-156 micrograms 24 h-1) and following dosing with D-penicillamine the median 24 h urinary bismuth output was 53 micrograms 24 h-1 (range 12-156 micrograms 24 h-1). D-penicillamine does not facilitate the urinary excretion of bismuth, hence it is unsuitable for use as an oral chelator in patients with bismuth intoxication.
Nwokolo
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CU
Academic Department of Medicine, Royal Free Hospital School of Medicine, London.
Pounder
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D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D001729:Bismuth / Q000506:poisoning / Q000652:urine*; D002614:Chelating Agents; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010396:Penicillamine / Q000494:pharmacology*; D011041:Poisoning / Q000188:drug therapy; D013056:Spectrophotometry, Ultraviolet
D000863:Antacids; D002614:Chelating Agents; D009942:Organometallic Compounds; D010396:Penicillamine; C002791:bismuth tripotassium dicitrate; D001729:Bismuth