[Theoretical examination of kinetic regularities in interaction of second messenger systems upon activation of cells by an external chemical signal].
A model of cell activation under the action of an external chemical signal is examined. The model is based on the assumption of simultaneous stimulation of, as a minimum, two different systems of second messengers interacting with each other. The kinetics of intracellular response may be principally different in character depending on the relation of model parameters. Ligand specificity manifests itself either in qualitative changes in the behavior of the system under the action of different ligands of the same class or in changes in the efficiency of intracellular response. In terms of these notions an interpretation of experimental data on cytoplasmic Ca2+ concentration oscillations in individual cells is presented. Methods for experimental verification of the model are considered.
Melikhova
E M
EM
Kurochkin
I N
IN
D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D007700:Kinetics; D008024:Ligands; D015290:Second Messenger Systems; D015398:Signal Transduction
D008024:Ligands; D002118:Calcium
Teoreticheskoe rassmotrenie kinetitcheskikh zakonomernoste'i protsessov vzaimodeĭstviia sistem vtorichnykh messendzherov pri aktivatsii kletki vneshnim khimicheskim signalom.