title: [Congenital muscular dystrophy. Report of 8 cases with evidence of central nervous system involvement].
abstract: Twelve patients with congenital muscular dystrophy (CMD) diagnosed by clinical and laboratorial criteria were submitted to CT scanning. Eight patients presented diffuse bilateral hypodensity of the white matter with predominance in the frontal lobes. These findings are indicative that CNS involvement in CMD is not confined to the Japanese population. Such involvement strongly suggests that the disease is transmitted by an autosomal recessive polymorphic gene responsible for the involvement of both CNS and skeletal muscle.
authors.affiliation: Disciplina de Neurologia da Escola Paulista de Medicina, São Paulo.
authors.forename: A S
authors.initials: AS
authors.lastname: Oliveira
authors.forename: A A
authors.initials: AA
authors.lastname: Gabbai
authors.forename: B H
authors.initials: BH
authors.lastname: Kiyomoto
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
mesh_terms: D001927:Brain Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D009136:Muscular Dystrophies / Q000151:congenital / Q000209:etiology*; D014057:Tomography, X-Ray Computed
vernacular_title: Distrofia muscular congênita. Apresentação de oito casos com evidência de comprometimento do SNC.