[Bactericidal activity of ofloxacin against Mycobacterium kansasii].
Bactericidal activity of ofloxacin against Mycobacterium kansasii was observed in in-vitro experiment. Tested bacteria were suspended to a concentration of one mg wet weight per ml in 10 ml of Dubos liquid medium containing no drug or containing 1 or 3 micrograms/ml ofloxacin and incubated at 37 degrees C. The number of colony-forming units contained in a 0.02 ml-sample of the Dubos liquid medium was counted after incubation for 0, 1, 3 and 7 days. The number of colonies was counted in Ogawa egg medium, to which was inoculated a 0.02 ml-sample of dilutions of the medium by a spiral loop that can deliver a 0.02 ml-sample by one inoculation. The bactericidal activity of ofloxacin against M. kansasii appeared after incubation of 3 days or later. This characteristic was different from the bactericidal activity against Mycobacterium tuberculosis, which appeared after incubation of 24 hours.
Tsukamura
M
M
Department of Microbiology, Fujita Gakuen Health University School of Medicine, Aichi, Japan.
D015169:Colony Count, Microbial; D008826:Microbial Sensitivity Tests; D009170:Nontuberculous Mycobacteria / Q000187:drug effects* / Q000254:growth & development; D015242:Ofloxacin / Q000494:pharmacology*
D015242:Ofloxacin