The parasitology of malaria and the study of protective immunity.
Phenotypic antigenic variation within parasite strains and antigenic diversity between strains are important parameters in understanding the development of immunity to malaria. With the Plasmodium chabaudi chabaudi model in inbred mice, a combination of serological tests and DNA technology can be used to study the specificity of inducer and effector mechanisms in an infection with characteristics similar in many ways to those of P. falciparum in man.
Brown
K N
KN
National Institute for Medical Research, London, U.K.
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D014644:Genetic Variation; D005838:Genotype; D008288:Malaria / Q000276:immunology* / Q000469:parasitology*; D010641:Phenotype; D010961:Plasmodium / Q000235:genetics / Q000276:immunology*
D000953:Antigens, Protozoan; D000954:Antigens, Surface