Interaction of ethanol, cholesterol and vitamin A on phospholipid methylation in hepatic microsomes of rats.
Effect of ethanol, cholesterol and vitamin A either alone or in combination has been studied on cyt P450 and phospholipid methylation in hepatic microsomes of rats. Ethanol increased cyt P450 activity and decreased phospholipid methylation. Cholesterol effects were opposite to ethanol. Combination of cholesterol and ethanol decreased cyt P450 activity and increased phospholipid methylation. Vitamin A, which alone did not affect cyt P450 activity and phospholipid methylation behaved like cholesterol when given along with ethanol.
Srivastava
R
R
Department of Biochemistry, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Srivastava
N
N
Misra
U K
UK
D000818:Animals; D002784:Cholesterol / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008745:Methylation; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*
D010743:Phospholipids; D014801:Vitamin A; D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol