Nicotinamide adenine dinucleotide (NAD)-dependent oxidation of nicotine-delta 1'(5')-iminium ion to cotinine by rabbit liver microsomes.
Obach
R S
RS
Department of Biochemistry, Brandeis University, Waltham, MA 02254.
Van Vunakis
H
H
D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001151:Arsenic / Q000494:pharmacology; D018053:Arsenites; D003367:Cotinine / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000494:pharmacology*; D009538:Nicotine / Q000031:analogs & derivatives* / Q000378:metabolism; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011760:Pyrrolidinones / Q000378:metabolism*; D011817:Rabbits; D014812:Vitamin K / Q000494:pharmacology; D014867:Water / Q000378:metabolism
D018053:Arsenites; D011760:Pyrrolidinones; D014867:Water; D009243:NAD; D014812:Vitamin K; D009538:Nicotine; C034629:nicotine imine; D010088:Oxidoreductases; D000445:Aldehyde Oxidoreductases; D042931:Aldehyde Oxidase; D003367:Cotinine; C015001:arsenite; D001151:Arsenic