Growth hormone receptors in hypothalamic and extra-hypothalamic tissues.
Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for 125I-labelled GH. RNA extracted from hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains contained mRNA that hybridized with a cDNA probe for the rabbit liver GHR. This transcript was of a similar size to the major GHR mRNA moiety in rabbit liver. The expression of these moieties was age related, and higher in adult than in neonatal animals.
Fraser
R A
RA
Department of Physiology, University of Alberta, Edmonton, Canada.
Attardo
D
D
Harvey
S
S
D000367:Age Factors; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D001923:Brain Chemistry; D002645:Chickens; D015342:DNA Probes / Q000138:chemical synthesis; D007031:Hypothalamus / Q000737:chemistry*; D008099:Liver; D015347:RNA Probes / Q000138:chemical synthesis; D011817:Rabbits; D011986:Receptors, Somatotropin / Q000032:analysis / Q000502:physiology*
D015342:DNA Probes; D015347:RNA Probes; D011986:Receptors, Somatotropin