Non-CS pre-erythrocytic protective antigens.
Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro.
Hollingdale
M R
MR
Biomedical Research Institute, Rockville, MD 20852.
Aikawa
M
M
Atkinson
C T
CT
Ballou
W R
WR
Chen
G X
GX
Li
J
J
Meis
J F
JF
Sina
B
B
Wright
C
C
Zhu
J D
JD
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology / Q000302:isolation & purification*; D008099:Liver / Q000469:parasitology; D051379:Mice; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology
D000953:Antigens, Protozoan; D010446:Peptide Fragments; D015800:Protozoan Proteins; C067302:liver stage-specific antigen, Plasmodium