title: A case of Leigh's disease with initial manifestation of dystonia.
abstract: A case of Leigh's disease (subacute necrotizing encephalomyelopathy) is reported with such noteworthy features as early onset, dystonia, paraparesis the presence of low attenuation areas in both basal ganglias on computerized tomography of the brain and the presence of a high signal intensity in both basal ganglias in T2 weighted image by MR. The electron microscopic findings of muscle biopsy are suggestive of pleoconial mitochondrial myopathy.
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: C W
authors.initials: CW
authors.lastname: Chung
authors.forename: S H
authors.initials: SH
authors.lastname: Hwang
authors.forename: Y C
authors.initials: YC
authors.lastname: Choi
authors.forename: Y H
authors.initials: YH
authors.lastname: Sohn
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: B C
authors.initials: BC
authors.lastname: Lee
authors.forename: J G
authors.initials: JG
authors.lastname: Chi
mesh_terms: D001479:Basal Ganglia / Q000473:pathology; D004421:Dystonia / Q000175:diagnosis / Q000209:etiology*; D004734:Energy Metabolism; D006801:Humans; D007223:Infant; D007888:Leigh Disease / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009132:Muscles / Q000473:pathology