Inhibitory actions of prostaglandin E1 on non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
We have investigated the effect of prostaglandin E1 (PGE1) on non-adrenergic, non-cholinergic (NANC) contraction in guinea-pig bronchial strips. PGE1 (10 nM to 10 microM) did not alter baseline tension but reduced NANC contractions induced by electrical field stimulation (EFS) in a concentration-dependent fashion (-log EC50 was 6.60 +/- 0.10 M and maximum inhibition was 88.7 +/- 2.9%). PGE1 (greater than 0.3 microM) also reduced the contraction induced by substance P (1 microM). Removal of epithelium did not alter the effects of PGE1 on NANC contraction. These results suggest that PGE1 exerts both pre- and post-junctional inhibitory actions on NANC contraction.
Aikawa
T
T
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Sekizawa
K
K
Itabashi
S
S
Sasaki
H
H
Takishima
T
T
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001980:Bronchi / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology*; D010069:Oxadiazoles
D009539:Nicotinic Acids; D010069:Oxadiazoles; C049834:PN 202-791; D000527:Alprostadil; D015232:Dinoprostone