Expression of neural cell adhesion molecule in dysmyelinating mutants.
The possible role of neural cell adhesion molecule (NCAM) in myelination was studied in the dysmyelinating mouse mutants jimpy and shiverer, by characterizing the expression of the different molecular forms of brain NCAM as a function of age. In jimpy, the expression of NCAM-120 (120,000-Da NCAM) was low and in shiverer both NCAM-120 and NCAM-180 (180,000-Da NCAM) were reduced when compared to controls. In both jimpy and shiverer there was no significant change in the phospholipase C-sensitive NCAM-120. These data further support the possibility that NCAM may be involved in myelination.
Bhat
S
S
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104.
Silberberg
D H
DH
D000818:Animals; D015153:Blotting, Western; D001923:Brain Chemistry / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D003711:Demyelinating Diseases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009186:Myelin Sheath / Q000502:physiology*; D013045:Species Specificity; D010738:Type C Phospholipases
D015816:Cell Adhesion Molecules, Neuronal; D010738:Type C Phospholipases