title: Diagnosis of bone and joint infection by leucocyte scintigraphy. A comparative study with 99mTc-HMPAO-labelled leucocytes, 99mTc-labelled antigranulocyte antibodies and 99mTc-labelled nanocolloid.
abstract: Fifty-five patients with 60 suspected infections of bones or joints were studied with 99mTc-hexamethylpropyleneaminooxine- (HMPAO-) labelled leucocytes and 99mTc-labelled antigranulocyte antibodies, in part supplemented with 99mTc-labelled nanocolloid. The findings using the different procedures were in good agreement. Apart from in vertebral lesions, a negative scan--even if the radionuclide bone scan is positive--excludes an infection with high probability (sensitivity 94%). The low specificity (57%) is due to positive imaging of various non-infected lesions. Spondylitis usually shows as non-specific cold lesions. A subtraction technique with computer assisted analysis of HMPAO and nanocolloid scans provides a more precise diagnosis of this condition.
authors.affiliation: Orthopedic Department, University of Bonn, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Rüther
authors.forename: A
authors.initials: A
authors.lastname: Hotze
authors.forename: F
authors.initials: F
authors.lastname: Möller
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: P
authors.initials: P
authors.lastname: Heitzmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D001170:Arthritis, Infectious / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D010091:Oximes; D011859:Radiography; D011877:Radionuclide Imaging / Q000379:methods* / Q000592:standards; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime
chemical_list: D000906:Antibodies; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime