[The effect of LPH on the behavior of parameters of the kallikrein-kinin system (KKS) in the early phase of experimental endotoxic shock in the rat].
The effect of a new shock-protective agent LPH on parameters of the kallikrein-kinin-system was studied in a standardized endotoxin shock model. Activation of KKS in endotoxin shock was not significantly influenced by LPH. On the other hand, LPH by itself caused activation of KKS. Decrease of kininogen level by endotoxin, however, was prevented by the pretreatment with LPH.
Kühne
H
H
Institut für Pathologische Biochemie, Medizinischen Akademie, Carl Gustav Carus Dresden.
Steinke
M
M
Knauf
U
U
Scheuch
D W
DW
D000818:Animals; D004195:Disease Models, Animal; D004723:Endorphins / Q000494:pharmacology* / Q000627:therapeutic use; D016234:Kallikrein-Kinin System / Q000187:drug effects*; D007704:Kininogens / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000517:prevention & control*
D004723:Endorphins; D007704:Kininogens
Einfluss von LPH auf das Verhalten von Parametern des Kallikrein-Kinin-Systems (KKS) in der Frühphase des experimentellen Endotoxinschocks der Ratte.