Protective synergic effect of coenzyme Q10 and carnitine on hyperbaric oxygen toxicity.
The comparative biochemical activities of coenzyme Q10 and carnitine can explain the protective synergistic effect of combination of these two substances in preventing the hyperbaric oxygen toxicity in mice. Both convulsions and mortality percentages are more significantly reduced in treated animals with these two substances in combination rather than separately.
Bertelli
A
A
Department of Pharmacology, University of Milan, Italy.
Bertelli
A A
AA
Giovannini
L
L
Spaggiari
P
P
D000818:Animals; D002331:Carnitine / Q000627:therapeutic use*; D003067:Coenzymes; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D051379:Mice; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D014451:Ubiquinone / Q000627:therapeutic use* / Q000031:analogs & derivatives
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10; D002331:Carnitine