title: Porphyrins and nucleic acid in some photosensitive skin diseases.
abstract: This study was suggested to evaluate the possible role of porphyrins and DNA, and their interaction, in some photosensitive premalignant and malignant dermatoses. Twenty-five patients with photosensitive skin diseases viz. xeroderma pigmentosum and basal cell carcinoma, were randomly selected at the outpatient clinic of Dermatology in Mansoura University Hospital. Twenty-five matched normal individuals were used as a control group. In basal cell carcinoma patients, a high increase in skin DNA and decrease in skin total porphyrin, haemoglobin and haem concentrations were observed. In xeroderma pigmentosum, a significant decrease in both skin DNA and skin total porphyrin were found, at the same time, there were elevations in urinary total porphyrin, PBG and ALA concentrations, and a high decrease in haemoglobin and haem levels.
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: el-Sharabasy
authors.forename: A A
authors.initials: AA
authors.lastname: Hegazy
authors.forename: M S
authors.initials: MS
authors.lastname: el-Soubky
authors.forename: M A
authors.initials: MA
authors.lastname: el-Maksoud
mesh_terms: D000622:Aminolevulinic Acid / Q000032:analysis* / Q000097:blood; D002280:Basal Cell Carcinoma / Q000097:blood / Q000378:metabolism*; D004247:DNA / Q000032:analysis* / Q000097:blood; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D011166:Porphyrins / Q000032:analysis* / Q000097:blood; D011524:Protoporphyrins / Q000032:analysis / Q000097:blood; D012016:Reference Values; D012867:Skin / Q000737:chemistry*; D012878:Skin Neoplasms / Q000097:blood / Q000378:metabolism*; D014983:Xeroderma Pigmentosum / Q000097:blood / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D011166:Porphyrins; D011524:Protoporphyrins; D000622:Aminolevulinic Acid; D004247:DNA