The viral hypothesis of Alzheimer's disease. Absence of antibodies to lentiviruses.
To evaluate the possible role of lentiviruses in Alzheimer's disease we searched for cross-reactive antibodies to human immunodeficiency virus type 1, caprine arthritis encephalitis virus, and equine infectious anemia virus in Alzheimer's disease, Down's syndrome, and related dementing illnesses in serum samples and cerebrospinal fluid samples and in healthy age-matched control subjects. No cross-reactive antibodies were detected.
Friedland
R P
RP
Section on Brain Aging and Dementia, National Institute on Aging, National Institutes of Health, Bethesda, MD 20891.
May
C
C
Dahlberg
J
J
D000368:Aged; D000544:Alzheimer Disease / Q000209:etiology* / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012190:Retroviridae / Q000276:immunology*; D014777:Virus Diseases / Q000150:complications*
D000914:Antibodies, Viral