Thermodynamic and structural effects of propranolol on DPPC liposomes.
Some thermodynamic and structural aspects of propranolol-DPPC liposomes interaction were investigated by DSC and X-ray diffraction: the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until 1:1 drug/lipid molar ratio). However, the bilayer thickness increases significantly and the chains become perpendicular to the lamellar planes, for increasing drug content. At still higher propranolol concentrations a hexagonal phase occurs followed by a lamellar phase, in which the liposomes are destroyed. Moreover, the presence of propranolol has been found to impart fluidity to the lipid matrix.
Albertini
G
G
Dipartimento di Scienze dei Materiali e della Terra, Ancona, Italy.
Donati
C
C
Phadke
R S
RS
Ponzi Bossi
M G
MG
Rustichelli
F
F
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry / Q000378:metabolism*; D002152:Calorimetry, Differential Scanning; D004305:Dose-Response Relationship, Drug; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D008567:Membranes, Artificial; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D013696:Temperature; D013816:Thermodynamics; D014961:X-Ray Diffraction
D008081:Liposomes; D008567:Membranes, Artificial; D015060:1,2-Dipalmitoylphosphatidylcholine; D011433:Propranolol