Effects of riboflavin on benzo(a)pyrene, 2-acetylaminofluorene and methyl methanesulfonate mutagenicity in vitro.
Riboflavin was shown to inhibit mutagenicity of benzo(a)pyrene and 2-acetylaminofluorene in the presence of S9 liver fractions deriving from B10.A mice as well as from DBA/2 mice and had no influence on mutagenicity of methyl methanesulfonate. The above findings confirm the supposition that antimutagenicity of riboflavin results from its interaction with enzymes responsible for metabolic activation of promutagens. The antimutagenic effects of riboflavin were more drastic in the presence of liver fractions from B10.A mice than in the presence of those from DBA/2 mice.
Ejchart
A
A
Institute for Drug Research and Control, Warszawa, Poland.
Chłopkiewicz
B
B
Czarnomska
A
A
Koziorowska
J
J
D015073:2-Acetylaminofluorene / Q000633:toxicity*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D008099:Liver / Q000378:metabolism; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D016296:Mutagenesis / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods; D012256:Riboflavin / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects
D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D015073:2-Acetylaminofluorene; D008741:Methyl Methanesulfonate; D001189:Aryl Hydrocarbon Hydroxylases; D012256:Riboflavin