title: Cytogenetic survey for autistic fragile X carriers in a mental retardation center.
abstract: A cytogenetic survey of 67 individuals previously identified as having mental retardation and autistic behaviors revealed 1 person (1.5%) with the fragile X chromosome (fra[X]) and 3 (4.5%) with autosome abnormalities. This low prevalence of fra(X) indicates that most persons with fra(X) in this mental retardation center did not have autistic behaviors severe enough to be identified as a secondary psychiatric diagnosis. The presence of other chromosomal abnormalities is consistent with the known causal heterogeneity of autism in mental retardation populations.
authors.affiliation: University of Florida College of Medicine.
authors.forename: E S
authors.initials: ES
authors.lastname: Cantú
authors.forename: J W
authors.initials: JW
authors.lastname: Stone
authors.forename: A A
authors.initials: AA
authors.lastname: Wing
authors.forename: H R
authors.initials: HR
authors.lastname: Langee
authors.forename: C A
authors.initials: CA
authors.lastname: Williams
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002871:Chromosome Banding; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics* / Q000517:prevention & control; D006580:Genetic Carrier Screening; D005820:Genetic Testing; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*