Hairy cell leukemia in two siblings. A human leukocyte antigen-linked disease?
Shared haplotypes have been documented in three of the four previously reported families with familial hairy cell leukemia (HCL). Human leukocyte antigen (HLA) typing was done on a four-member sibship in which two siblings had hairy cell leukemia. The two affected siblings share the haplotype A2; Bw6, Bw62(15); Cw1; DR4, DRw53; DQw3. No one HLA antigen or haplotype is common among the five families reported at this time. These limited data suggest HCL is not associated with a specific HLA antigen. HLA typing of a larger collection of cases of familial HCL may help better define what role, if any, inheritance plays in the occurrence of this rare disorder among numerous first degree relatives.
Ward
F T
FT
Department of Pathology, Walter Reed Army Medical Center, Washington, DC 20037-5001.
Baker
J
J
Krishnan
J
J
Dow
N
N
Kjobech
C H
CH
D000368:Aged; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens