title: A clinicopathologic study of primary hepatic carcinoid tumors.
abstract: Six cases of primary hepatic carcinoid tumors were studied with combined immunocytochemical and electron microscopic techniques. Positive tumor immunostaining with PHE5, LK2H10, neuron-specific enolase (NSE), serotonin, gastrin, and insulin antibodies was observed. At the ultrastructural level, cytoplasmic dense granules were seen in all the cases tested. This finding supports a putative origin of these carcinoids found in the liver from a pluripotential stem cell. The clinical course and follow-up of these cases suggests that this unusual hepatic neoplasm has a more favorable prognosis than other forms of hepatic cancer.
authors.affiliation: Department of Pathology and Cytology, Istituto Nazionale Tumori, Milano, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Andreola
authors.forename: L
authors.initials: L
authors.lastname: Lombardi
authors.forename: R A
authors.initials: RA
authors.lastname: Audisio
authors.forename: V
authors.initials: V
authors.lastname: Mazzaferro
authors.forename: D
authors.initials: D
authors.lastname: Koukouras
authors.forename: R
authors.initials: R
authors.lastname: Doci
authors.forename: L
authors.initials: L
authors.lastname: Gennari
authors.forename: L
authors.initials: L
authors.lastname: Makowka
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
authors.forename: D H
authors.initials: DH
authors.lastname: van Thiel
mesh_terms: D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged