title: The inhibitory effect of quinacrine on contractile responses to norepinephrine in isolated rabbit aorta.
abstract: 1. In rabbit aorta, quinacrine, but not indomethacin nor nordihydroguaiaretic acid, inhibited contractile responses to norepinephrine and KCl. Amiloride and nifedipine did not affect the effect of quinacrine. 2. In Ca2(+)-free medium, quinacrine (3 x 10(-6)-10(-4) M) inhibited the norpinephrine response less than that to a subsequent addition of Ca2+. 3. M&B 22, 948, nitroglycerin and forskolin inhibited the Ca2+ response. The effect of quinacrine was inhibited by M&B 22,948, but not by forskolin and potentiated by nitroglycerin. 4. Quinacrine and M&B 22,948 potentiated the nitroglycerin-relaxation. The effect of quinacrine plus M&B 22,948 was not different from that of quinacrine. 5. These results indicate that the effect of quinacrine may be different from that of nifedipine but is related to cGMP.
authors.affiliation: Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu 96822.
authors.forename: N
authors.initials: N
authors.lastname: Satake
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Shibata
mesh_terms: D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D004347:Drug Interactions; D066298:In Vitro Techniques; D007293:Inosine Triphosphate / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011796:Quinacrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D007293:Inosine Triphosphate; D011189:Potassium Chloride; D000584:Amiloride; D011796:Quinacrine; D009543:Nifedipine; D002118:Calcium; D009638:Norepinephrine