[Pharmacokinetic parameters of prednisone and prednisolone in healthy volunteers].
A cross-over, double-blind, randomized trial with 8 healthy volunteers was undertaken to compare prednisolone and prednisone pharmacokinetics after a single oral dose (1 mg/kg) of prednisone (Cortancyl) and prednisolone sodium metasulfobenzoate (Solupred). Maximum prednisolone concentrations measured after ingestion of prednisone are higher (535 +/- 32 ng/ml) and occur earlier than after taking prednisolone sodium metasulfobenzoate (198 +/- 114 ng/ml) (p less than 0.001). The areas under the curve are significantly larger after prednisone than after prednisolone sodium metasulfobenzoate (p less than 0.02). These findings suggest a decreased systemic availability of prednisolone after prednisolone sodium metasulfobenzoate (Solupred) administration and show, from a strictly pharmacokinetic point of view, that equimolar doses of prednisone and prednisolone sodium metasulfobenzoate are not equivalent therapies.
Etienne
S D
SD
Service de Médecine Interne de la Pitié, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Vandermeersch
V
V
Chosidow
O
O
Vu-Thi-My-Le
C
C
Godeau
P
P
Diquet
B
B
Herson
S
S
D000328:Adult; D001682:Biological Availability; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000378:metabolism / Q000493:pharmacokinetics*; D011241:Prednisone / Q000378:metabolism / Q000493:pharmacokinetics*
D011239:Prednisolone; D011241:Prednisone
Paramètres pharmacocinétiques de la prednisone et de la prednisolone chez le volontaire sain.