title: Low dose rate teletherapy using a telecaesium 137 unit radiobiological, physical and clinical considerations.
abstract: Low dose rate teletherapy aims to combine the supposedly superior results obtained with low dose rate implants with the convenience and staff protection characteristics of external beam therapy. Previous investigators have used telecobalt units to produce dose rates of 1.1 to 1.8 Gy/hr to treat in daily sessions lasting 6-10 hours to total doses of 60-70 Gy. These studies have not discounted the possibility that much of the advantage of interstitial implants results from the low dose rates used per se, and from the fact that the total dose is delivered in a short overall time. The relationship between total dose, dose rate and volume giving normal tissue and anit-tumour effects, however, remains ill-defined. At the Newcastle Mater Misericordiae Hospital a Caesium teletherapy unit has been modified to treat at low dose rates and a study has been designed with a view to establish which permutations of total dose and dose rate are isoeffective for acute mucosal and acute skin reactions in the dose rate range between 0.8 and 9.6 Gy/hr (1.3 and 16 cGy/min).
authors.affiliation: Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital.
authors.forename: S G
authors.initials: SG
authors.lastname: Cooper
authors.forename: A P
authors.initials: AP
authors.lastname: Cardew
authors.forename: S
authors.initials: S
authors.lastname: Ferguson
authors.forename: D J
authors.initials: DJ
authors.lastname: Joseph
authors.forename: C S
authors.initials: CS
authors.lastname: Hamilton
authors.forename: J W
authors.initials: JW
authors.lastname: Denham
authors.forename: A R
authors.initials: AR
authors.lastname: Williams
mesh_terms: D002588:Cesium Radioisotopes / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011867:Radioisotope Teletherapy / Q000295:instrumentation*; D011879:Radiotherapy Dosage
chemical_list: D002588:Cesium Radioisotopes