Allele frequency estimation at loci with incomplete co-dominant expression.
Although allelic variants at a locus usually are expressed either dominantly or co-dominantly, there are many cases when a gene is dominantly expressed in some individuals and co-dominantly in others. We present a maximum-likelihood procedure for allele frequency estimation in such situations of "incomplete" co-dominant gene expression at an autosomal locus that segregates for two alleles. Our proposed estimator generally is less biased and has a smaller sampling variance than those previously described.
Jorde
P E
PE
Department of Genetics, Stockholm University, Sweden.
Ryman
N
N
D000483:Alleles; D000704:Analysis of Variance; D000818:Animals; D015982:Bias; D003627:Data Interpretation, Statistical; D015870:Gene Expression; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans