title: Rabies reference vaccine for use as a regional standard for Latin America and the Caribbean countries.
abstract: A candidate rabies reference vaccine of suckling mouse brain (SMB) origin was prepared and standardized at the Pan American Zoonoses Center (PAHO/WHO) and evaluated in a collaborative study involving seven laboratories. On the basis of three different tests, its potency, immunogenicity, and stability were demonstrated to be satisfactory. The vaccine was proposed for consideration of the Latin American and Caribbean countries as a regional standard to determine the potency of SMB vaccines, the most widely used in the Region.
authors.affiliation: Pan American Zoonoses Center PAHO/WHO, Buenos Aires, Argentina.
authors.forename: A M
authors.initials: AM
authors.lastname: Diaz
authors.forename: R A
authors.initials: RA
authors.lastname: Miller
authors.forename: M A
authors.initials: MA
authors.lastname: Cortés
authors.forename: N
authors.initials: N
authors.lastname: Dellepiane
authors.forename: D
authors.initials: D
authors.lastname: Elberger
authors.forename: F
authors.initials: F
authors.lastname: Fábrega
authors.forename: G
authors.initials: G
authors.lastname: Miceli
authors.forename: G
authors.initials: G
authors.lastname: Mendoza
authors.forename: M E
authors.initials: ME
authors.lastname: Obarrio
authors.forename: M T
authors.initials: MT
authors.lastname: Ochoa
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004355:Drug Stability; D006801:Humans; D007843:Latin America; D051379:Mice; D011819:Rabies Vaccines / Q000276:immunology / Q000592:standards*; D011820:Rabies virus / Q000276:immunology; D012015:Reference Standards; D014900:West Indies
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines