[Interference of clindamycin in skin infection in rabbits caused by suture threads infected with slime-producing S. epidermidis].
The authors have carried out an experimental study to evaluate the interference of sub-inhibitory concentrations of clindamycin on the adherence of slime producing S. epidermidis to surgical nets and its ability to infect rabbits. 80 rabbits divided into 4 groups, (A, B, C, and D), underwent sham operation of the abdominal zone and were sewn up with sterile nets, infected nets and sub MIC of clindamycin equal to 1/8 MIC, respectively. The results obtained stressed a different survival rate 12 days after operation: 95% in group A, 35% in group B; 100% in group C and 95% in group D. This data were confirmed by the results obtained using MES (Cambridge Stereosecan 150 KM2). From our research an excellent clindamycin inhibitory activity on the pathogenicity of slime producing staphylococci emerged.
Gismondo
M R
MR
Istituto di Microbiologia, Università degli Studi di Catania.
Lo Bue
A M
AM
Chisari
G
G
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002981:Clindamycin / Q000494:pharmacology*; D011817:Rabbits; D012874:Skin Diseases, Infectious / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D013537:Sutures
D002981:Clindamycin
Interferenza della clindamicina sull'infezione cutanea del coniglio dovuta a fili di sutura infettati con S. epidermidis produttore di slime.