title: Cimetidine for treatment of melanomas in three horses.
abstract: Cimetidine, an H2 histamine antagonist, was used in the clinical management of progressive, multifocal melanomatosis in 3 adult gray horses. Prior to treatment, the tumors had increased rapidly in size and number in 2 horses (duration of 6 and 27 months, respectively) and slowly in the third horse (duration of 48 months). All 3 horses were treated with cimetidine (2.5 mg/kg of body weight, PO, q 8 h) for 2 months to 1 year. During treatment, the number and size of the melanomas decreased substantially (50 to 90%). The progression of the disease was halted in 2 horses and controlled in the third horse, which is still being treated with cimetidine (1.6 mg/kg, PO, q 24 h). The horses in which treatment was terminated have not been treated for 31 and 41 months, respectively, during which time the melanomas have not increased in number or size.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors.forename: T E
authors.initials: TE
authors.lastname: Goetz
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: K G
authors.initials: KG
authors.lastname: Keegan
authors.forename: P J
authors.initials: PJ
authors.lastname: Johnson
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000662:veterinary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D002927:Cimetidine