[Effect of a synthetic somatostatin analogue with delayed action (SMS 201-995) on the biliary expenditure in a patient with an external biliary tract fistula].
The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.
Miranda-Ruiz
R
R
Unidad de Investigación de Endocrinología, IMSS, México, D.F.
Castañón-González
J
J
Pérez Aldana
C
C
Arias
E
E
Díaz de León Ponce
M
M
Zárate
A
A
D000328:Adult; D001646:Bile / Q000378:metabolism*; D001658:Biliary Fistula / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D005402:Fistula / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology
D003692:Delayed-Action Preparations; D015282:Octreotide
Efecto de un análogo sintético de somatostatina de acción prolongada (SMS 201-995) sobre el gasto biliar en un paciente con una fístula externa de las vías biliares.