Comparative studies of angiotensin II and its analog [Sar1Ala8]angiotensin II on the density of cellular monolayer of cell cultures from green monkey kidney.
The effects of the octapeptide angiotensin II (AT II) and its analog [Sar1Ala8]AT II on the cell density in cell culture from green monkey kidney (GMK) were studied. AT II and [Sar1Ala8]AT II provoked a decrease of the number of living cells depending on the concentration (0.001, 0.01 and 0.1 nM) and time of incubation (24, 48 and 72 hours), both peptides having a very similar activity. These data indicate that AT II and [Sar1Ala8]AT II may act on the same class of angiotensin receptors in GMK cells.
Lambadjieva
N
N
Department of Human and Animal Physiology, Faculty of Biology, University of Sofia, Bulgaria.
Georgiev
V
V
Ivanov
R
R
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D005347:Fibroblasts / Q000187:drug effects*; D007668:Kidney; D011945:Receptors, Angiotensin / Q000145:classification / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology*
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D012504:Saralasin