title: [Antagonism of Zn2+ on nootropic action of piracetam in mice].
abstract: In mouse step-down test, the memory impairments of acquisition, consolidation and recognition were induced by anisodine, chloramphenical and ethanol, respectively. Piracetam 100 mg/(kg.d) ip for 5 d improved the anisodine-induced impairment of learning. ZnSO4 5 mg/(kg.d) po for 5 d did not improve the 3 impairments. Memory impairments were enhanced by a combined administration of ZnSO4 and piracetam in these 3 models. These results were confirmed by Y-maze method in normal mice.
authors.affiliation: Department of Pharmacology, Wenzhou Medical College, China.
authors.forename: T J
authors.initials: TJ
authors.lastname: Zhu
authors.forename: X Y
authors.initials: XY
authors.lastname: Chen
authors.forename: J C
authors.initials: JC
authors.lastname: Pan
authors.forename: S S
authors.initials: SS
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010889:Piracetam / Q000494:pharmacology*; D013431:Sulfates / Q000037:antagonists & inhibitors*; D015032:Zinc / Q000037:antagonists & inhibitors*; D019287:Zinc Sulfate
chemical_list: D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc; D010889:Piracetam