[Method for developing a controlled process. Study of the possible regulation of rifamycin B biosynthesis].
A procedure for developing a controlled process for biosynthesis of secondary metabolites is described with reference to rifamycin B as an example. The response of the antibiotic producing culture to changed concentrations of the main nutrients in the initial medium was determined. Mathematical processing of the experimental findings with design of the experiment resulted in defining nutrients such as ammonium sulfate and cornsteep liquor useful for further development of the controlled process.
Kuz'mina
L M
LM
Krasnova
T P
TP
Lysko
A V
AV
Vostrikova
V N
VN
Rychkov
A E
AE
Kolesnikova
N A
NA
Mal'tsev
N I
NI
D000645:Ammonium Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005285:Fermentation / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D007218:Industrial Microbiology / Q000379:methods*; D008433:Mathematics; D009615:Nocardia / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D012294:Rifamycins / Q000096:biosynthesis*; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology; D014586:USSR; D003313:Zea mays
D003470:Culture Media; D010936:Plant Extracts; D012294:Rifamycins; D013395:Sucrose; C033974:rifamycin B; D005947:Glucose; D000645:Ammonium Sulfate
Metod razrabotki upravliaemogo protsessa. Issledovanie vozmozhnosti reguliatsii biosinteza rifamitsina B.