Successful segmental intestinal transplantation in enterectomized pigs.
The aim of this study was to determine whether short-segment jejunal allografts maintained the viability and nutritional status of outbred recipient pigs treated with low-dose cyclosporine. The animals were subjected to total small bowel resection (from the ligament of Treitz to the ileocecal valve, approximately 15 m). Short-gut control animals (n = 8) who had no transplant died of malabsorption on day 62.5 +/- 4.1 (mean +/- SEM). Without cyclosporine immunosuppression, recipients (n = 5) of 3 m to 4 m jejunal allografts died of rejection on day 8.8 +/- 0.7. However enterectomized pigs (n = 11) who had segmental jejunal allograft transplants and were treated with cyclosporine (10 mg/kg/day) demonstrated significantly prolonged survival (to day 80.9 +/- 22.3; p less than 0.05). By 180 days after transplant, surviving animals increased their weight by almost 40%. In conclusion short-segment jejunal allografts significantly improved the mortality and morbidity rates from surgically created short bowel syndrome in pigs.
Kimura
K
K
Department of Surgery, State University of New York, Brooklyn 11203.
LaRosa
C A
CA
Blank
M A
MA
Jaffe
B M
BM
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D007421:Intestine, Small / Q000601:surgery; D007583:Jejunum / Q000637:transplantation*; D012778:Short Bowel Syndrome / Q000503:physiopathology; D013552:Swine; D014184:Transplantation, Homologous / Q000401:mortality
D003524:Cyclosporins