[The stimulation of DNA synthesis in resting Swiss 3T3 cells by non-histone chromosomal proteins].
Nonhistone chromosomal proteins (NHC), isolated from the kidney and liver of intact rats, the liver of rats treated with hepatocarcinogen DEN and the rat hepatoma, stimulate DNA synthesis in Swiss 3T3 cells in resting culture. The maximum stimulating effect was obtained in the presence of narrow NHC fractions eluted with 0.4-0.5 M NaCl from the phosphocellulose column and identified as hetero-organic NHC protein antigens of the kidney origin associated with hepatocellular tumors.
Barkan
R S
RS
Grandilevskaia
A B
AB
Kushner
V P
VP
Fel'
V Ia
VIa
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000302:isolation & purification / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D004052:Diethylnitrosamine; D007668:Kidney; D008099:Liver; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D051379:Mice; D009363:Neoplasm Proteins / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D002868:Chromosomal Proteins, Non-Histone; D009363:Neoplasm Proteins; D004052:Diethylnitrosamine; D004247:DNA
Stimuliatsiia sinteza DNK v pokoiashchikhsia kletkakh Swiss 3T3 negistonovymi khromosomal'nymi belkami.