title: [The influences of morphine microinjected into preoptic area on electric activities of pain response neurons in parafascicular nucleus of thalamus in rat].
abstract: We have observed the influences of opioid-like substances in preoptic area (POA) on the electric activities of pain response neurons in parafascicular nucleus of thalamus (Pf). The results were as follows: 1. Morphine 10 micrograms/microliters or 1 micrograms/microliters microinjected into POA could remarkably inhibit the pain discharges of most (20/26, 19/23 respectively) pain excitatory neurons (PEN) in Pf. The frequency of evoked discharges was decreased nd the duration was shortened. After injecting 10 micrograms/microliters morphine, three neurons showed inhibitory responses to noxious stimuli. 2. Morphine of the two doses could shorten the complete inhibitory period of pain inhibitory neurons (PIN, 23/33). These results suggest that the opioid-like substances in POA might have an inhibitory effects on pain response neurons in Pf.
authors.affiliation: Department of Physiology, Harbin Medical University.
authors.forename: L J
authors.initials: LJ
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Xu
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005260:Female; D008297:Male; D008845:Microinjections; D009020:Morphine / Q000494:pharmacology*; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*
chemical_list: D009020:Morphine