[Effects of nifedipine and riodipine on biochemical processes in intact erythrocytes].
Cardiovascular drugs nifedipine and riodipine (1,4-dihydropyridine derivatives) were studied as to their effect on some biochemical characteristics of erythrocytes. Both compounds failed to effect 2,3-diphosphoglycerate concentration in intact erythrocytes, but slightly decreased the level of adenosinetriphosphate. The drugs inhibited the process of acid hemolysis, this inhibition being particularly manifest in the case of nifedipine.
Tirzite
D Ia
DIa
Tirzit
G D
GD
Dubur
G Ia
GIa
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000959:Antihypertensive Agents; D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D009543:Nifedipine; C045912:ryodipine
Vliianie nifedipina i riodipina na biokhimicheskie protsessy v intaktnykh éritrotsitakh.