title: Effect of thyroid deficiency on actin mRNA content in the developing rat cerebellum.
abstract: The actin mRNA content of the cerebellum was determined in normal and hypothyroid developing rats using RNA dot hybridization with a beta-actin cDNA probe. The decline in actin mRNA content occurring during the second postnatal week in normal development was delayed by about 1 week in hypothyroid rats. Since this effect coincides exactly with the delay in actin filament formation recently reported in thyroid-deficient rats, it strengthens the hypothesis of an inverse relationship in the developing brain between the polymerization state of actin and the production of actin mRNA.
authors.affiliation: CNRS URA 1197, Université des Sciences et Techniques du Languedoc, Montpellier, France.
authors.forename: C
authors.initials: C
authors.lastname: Faivre-Sarrailh
authors.forename: C
authors.initials: C
authors.lastname: Ferraz
authors.forename: J P
authors.initials: JP
authors.lastname: Liautard
authors.forename: A
authors.initials: A
authors.lastname: Rabié
mesh_terms: D000199:Actins / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000199:Actins; D012333:RNA, Messenger