Comparative measurements of membrane potentials in chromaffin cells from spontaneously hypertensive and from normotensive WKY rats.
Comparative measurements of the membrane potential (MP) of chromaffin cells (CC) were made in tissue slices of adrenals from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls. We found for SHR a mean MP of -30.2 +/- 0.71 mV and for WKY a mean value of -33.0 +/- 0.80 mV. There was no significant difference between the mean MPs of the left and right adrenals of both rat strains. In the presence of 5.10(-5) M acetylcholine the mean MP significantly fell by 6.3 mV (SHR) and 9.7 mV (WKY), respectively. The present results indicate that different enzyme activities and processes of catecholamine storage in adrenals of SHR and WKY are obviously not correlated with changes in the MP of CC.
Richter
R
R
Institute of Drug Research, Academy of Sciences, Berlin, GDR.
D000109:Acetylcholine / Q000494:pharmacology; D000313:Adrenal Medulla / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002838:Chromaffin System / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D000109:Acetylcholine