[Pregnancy following organ transplantation].
In 17 of 74 patients, in the 20-40 years of age group, who had undergone an organ transplantation (kidney or liver), the course and outcome of pregnancy were evaluated. In three cases, the pregnancies ended in premature miscarriage and in five cases they were terminated for medical reasons. Nine infants were born alive between the 32nd to the 40th week of gestation, six of them spontaneously, three of them by abdominal Caesarean section. One of these infants born in the 32nd week of gestation with a birth weight of 800 grams died on the second day after birth. One infant born in the 33rd week of gestation showed incidence of a persistent ductus arteriosis Botalli. Four of the nine newborns suffered from intrauterine dystrophy. The birth weight of four further infants corresponded to the 10th to 25th percentile. Neither the incidence of a maternal varicella zoster infection in the early stages of pregnancy nor the reactivation of a herpes simplex (HSV) and cytomegalia virus infection during the pregnancy resulted in any perceptible damage to the infant or transplant. During pregnancy, three of the mothers were treated with immunosuppressants, either with a combination of azathioprine and prednisone (conventional) or cyclosporine (CSA) and prednisone, or with a combination of all three drugs (triple therapy). As opposed to the newborn of those mothers, who had been treated conventionally, the newborn of those treated with CSA showed post partum a tendency towards hypocalcaemia. Two of the mothers gave birth to their infants outside the Federal Republic of Germany.(ABSTRACT TRUNCATED AT 250 WORDS)
Kraemer-Hansen
H
H
Urologische Klinik, Universitäts-Krankenhaus Hamburg-Eppendorf.
Goepel
E
E
Ulmer
H U
HU
Bitzan
M
M
Press
C
C
Kopp
A
A
Henne-Bruns
D
D
Kremer
B
B
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006084:Graft Rejection / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007231:Infant, Newborn; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D007752:Obstetric Labor, Premature / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*
D007166:Immunosuppressive Agents
Schwangerschaften nach Organtransplantation.