In vivo recovery of Schwann cell-neuronal interactions altered by nerve growth factor suppression in the rat.
Recovery of Schwann cell-neuronal interactions altered by suppression of endogenous nerve growth factor (NGF) with antibodies to NGF (anti-NGF) was determined by morphometric analysis of unmyelinated and myelinated sensory fibers in the T9 dorsal roots in 3 groups of animals: (1) rats one week after cessation of anti-NGF treatment (anti-NGF + 1WK), (2) rats given antibodies to NGF (anti-NGF) and (3) untreated same age littermates (UNTR). The results indicate that (1) recovery of normal myelination begins within one week of cessation of anti-NGF treatment for small caliber fibers and (2) the observed results of anti-NGF treatment on Schwann cell-neuronal interactions were due to anti-NGF treatment and were not an indirect effect of a general diseased state.
Urschel
B A
BA
Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77550-2772.
Hulsebosch
C E
CE
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000008:administration & dosage*; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000502:physiology* / Q000648:ultrastructure; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012583:Schwann Cells / Q000502:physiology* / Q000648:ultrastructure
D000906:Antibodies; D009414:Nerve Growth Factors