Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.
The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.
Kodama
T
T
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Freeman
M
M
Rohrer
L
L
Zabrecky
J
J
Matsudaira
P
P
Krieger
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002460:Cell Line; D003001:Cloning, Molecular; D003094:Collagen; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D008077:Lipoproteins, LDL / Q000378:metabolism; D046911:Macromolecular Substances; D008264:Macrophages / Q000032:analysis*; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011971:Receptors, Immunologic / Q000235:genetics; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D008077:Lipoproteins, LDL; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; C032629:acetyl-LDL; D003094:Collagen; D004247:DNA