Cerebral gigantism: report of one case.
One case with the chief complaint of large head was diagnosed as cerebral gigantism (Sotos syndrome) according to the clinical picture and brain computerized tomography. This case, a one-year-old female infant, experienced rapid growth. Her height and head girth were excessive. Some degree of psychomotor retardation was present. Physical features included macrocrania, dolichocephaly, frontal bossing, hypertelorism, high-arched palate, large hands and feet. Cerebral ventricles were mildly dilated on brain computerized tomography. The diagnosis lied mainly on clinical characteristics. Diseases need to be differentiated from Sotos syndrome include fragile X syndrome, arrested hydrocephalus, Canavan disease and Alexander's disease.
Chu
T H
TH
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
Wang
P J
PJ
Lin
M Y
MY
Shen
Y Z
YZ
D003937:Diagnosis, Differential; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis; D005877:Gigantism / Q000175:diagnosis*; D006257:Head / Q000002:abnormalities*; D006801:Humans; D007223:Infant