A study of aluminum phosphide (AlP) poisoning with special reference to electrocardiographic changes.
Ninety patients with aluminum phosphide poisoning have been studied over a period of 3 years. Epigastric pain and vomiting were the common initial clinical features, followed 12 to 24 hours later by cardiogenic shock, oliguria, altered mental state and respiratory distress. Death occurred within 24 to 72 hours presumably due to poison-induced toxic chemical myocarditis as reflected by electrocardiographic changes. The overall mortality was 63.3%. Intravenous magnesium sulphate, probably due to its membrane stabilizing action, appears to be related to the reduction in mortality from 90% to 52% in the latter 62 cases.
Katira
R
R
Department of Medicine, LLRM Medical College, Meerut.
Elhence
G P
GP
Mehrotra
M L
ML
Srivastava
S S
SS
Mitra
A
A
Agarwala
R
R
Ram
A
A
D000293:Adolescent; D000328:Adult; D017607:Aluminum Compounds; D002648:Child; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000139:chemically induced* / Q000188:drug therapy; D010575:Pesticides / Q000506:poisoning*; D010720:Phosphines / Q000506:poisoning*
D017607:Aluminum Compounds; D010575:Pesticides; D010720:Phosphines; D008278:Magnesium Sulfate; C001864:aluminum phosphide