Reye and Reye-like syndromes: results of a pilot study in Peninsular Malaya, 1986.
A pilot epidemiologic study of all cases of Reye and Reye-like syndromes was undertaken at 8 representative major hospitals in Peninsular Malaya from January 1st to December 31st 1986. The cases were classified as definitive Reye's syndrome, clinical Reye's syndrome and encephalo-hepatopathies. Less than 50% of cases reviewed fulfilled the National Center for Disease Control criteria for clinical Reye's syndrome. Causes of Reye-like syndromes/encephalo-hepatopathies included fulminant hepatitis, Japanese B encephalitis, dengue, septicaemia, and complex febrile fits. It was not possible to differentiate clinical Reye's syndrome from the other encephalo-hepatopathies by either the clinical features (except for jaundice) or biochemical parameters. Liver biopsy is necessary for a definitive diagnosis of Reye's syndrome in Malaysia, because of the high prevalence of Reye-like diseases. The mortality rate in the 2 groups of patients is similar. Ingestion of salicylates was not found to be significantly associated with Reye and Reye-like syndromes in this study.
Sinniah
D
D
Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Sinniah
R
R
Yap
Y F
YF
Singh
M
M
George
R
R
Lim
N L
NL
Balakrishnan
S
S
D'Cruz
F
F
Ariffin
W
W
Kaur
P
P
D003937:Diagnosis, Differential; D004660:Encephalitis / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D012202:Reye Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality