title: Pathogenetic substantiation of extracorporeal detoxication in surgery.
abstract: The report is based on the results of treatment of 116 patients with severe purulent-destructive abdominal cavity diseases and 320 patients with liver failure due to bile ducts obturation. Along with surgical operations, methods of organism extracorporeal detoxication-haemosorption, exchange plasmapheresis, autoblood ultraviolet irradiation--were used in all patients either in isolation or in combination with each other. Toxical metabolites concentration, blood integral toxicity, peptids with mean molecular weight concentration, liver profile enzimes activity, lipid metabolism indices, general and liver haemodynamics and electroencephalogram were studied. On the basis of correlations between indices obtained by the method of extreme grouping factors-syndromes were formed, and then in accordance with a special program summary evaluation of detoxication was calculated in marks. A drop in lethality by 28.3% was ensured, as well as a drop in postoperatyonal liver failure by 51.4%.
authors.affiliation: M.F. Vladimirsky Moscow Regional Research Clinical Institute.
authors.forename: L A
authors.initials: LA
authors.lastname: Ender
authors.forename: A M
authors.initials: AM
authors.lastname: Lekhtman
authors.forename: A I
authors.initials: AI
authors.lastname: Lobakov
mesh_terms: D001769:Blood / Q000528:radiation effects; D004731:Endotoxins / Q000097:blood* / Q000302:isolation & purification; D005112:Extracorporeal Circulation / Q000379:methods*; D006464:Hemoperfusion; D006801:Humans; D010951:Plasma Exchange; D010956:Plasmapheresis; D014115:Toxemia / Q000097:blood / Q000628:therapy*; D014467:Ultraviolet Therapy
chemical_list: D004731:Endotoxins