[Features of the effects of disaccharide structure of saccharose on kinetic parameters of hepatic lipid synthesis from glucose (mechanism of disaccharide effect)].
Effects of saccharose or invert sugar on kinetics of lipid synthesis in the rat liver were investigated using 1-14C-glucose as a precursor. The diet containing 30% of saccharose (of the total energy value) for 40 days was found to be sufficient to increase the radioactive carbon flux through total liver lipids more than twice, and through rapidly metabolized neutral lipids and phospholipids more than 4 and 3 times, consequently. On the contrary, when the invert sugar diet was used the radioactive carbon flux through total lipids in the liver was reduced up to 54% of the control level, the lowest radioactive carbon flux was observed through the rapidly metabolized fraction of phospholipids--6% of the control level, only. These changes were caused by the corresponding alterations in lipid synthesis constants.
Virovets
O A
OA
Shpitonkov
M I
MI
Sokolov
A I
AI
Gapparov
M M
MM
D000818:Animals; D002250:Carbon Radioisotopes; D004187:Disaccharides / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000378:metabolism*
D002250:Carbon Radioisotopes; D004187:Disaccharides; D008055:Lipids; D010743:Phospholipids; D013395:Sucrose; D005947:Glucose
Osobennosti vliianiia disakharidnoĭ struktury sakharozy na kineticheskie parametry sinteza lipidov pecheni iz gliukozy (k voprosu o mekhanizme disakharidnogo éffekta).