title: Sister chromatid exchanges in patients with oral submucous fibrosis.
abstract: The incidence of sister chromatid exchange (SCE) was investigated in the lymphocyte chromosomes of 45 patients with oral submucous fibrosis and 56 age- and sex-matched nonsmoking controls. The frequency of SCE was 9.26 +/- 2.15 in patients with oral submucous fibrosis, which was significantly higher than the mean SCE value of 5.49 +/- 1.24 observed in normal controls. The frequency of SCE in patients with oral submucous fibrosis addicted to the habit of betel with tobacco chewing, "bidi"/cigarette smoking and combined habits of chewing and smoking of tobacco were 8.12 +/- 1.69, 9.43 +/- 1.87, and 10.06 +/- 2.28, respectively. These values were also significantly higher as compared with the SCE values observed in normal controls.
authors.affiliation: Department of Anthropology, University of Delhi, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Ghosh
authors.forename: R
authors.initials: R
authors.lastname: Madhavi
authors.forename: M
authors.initials: M
authors.lastname: Guntur
authors.forename: R
authors.initials: R
authors.lastname: Ghosh
mesh_terms: D000328:Adult; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D009059:Mouth Diseases / Q000235:genetics*; D009914:Oral Submucous Fibrosis / Q000209:etiology / Q000235:genetics*; D010947:Plants, Toxic; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects; D014030:Tobacco, Smokeless