[Pulmonary surfactant system of newborn rats in alcoholic intoxication of pregnant rats].
Data, received in investigation of the lungs of 45 newborn rats, show, that there is the suppression of the surface active properties of surfactant in animals, born from female rats with simulated alcoholic intoxication in pregnancy period. The decrease of the surface activity of surfactant may be connected with direct injury influence of alcohol on surfactant as well as with inactivation of surfactant with serum proteins, which appear in the alveolar space because of the increase of the permeability of components of air-haematic barrier. The suppression of the surface active properties of surfactant is accompanied by reinforcement of the functional activity of the 2nd type pneumocytes and appearance of the hypertrophic forms of these cells.
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D000818:Animals; D000831:Animals, Newborn; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology; D008168:Lung / Q000473:pathology / Q000648:ultrastructure; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D011663:Pulmonary Surfactants
Sistema surfaktanta legkikh novorozhdennykh krysiat pri alkogol'noĭ intoksikatsii beremennykh samok.