title: Injection rate: a factor in contrast reactions?
abstract: A prospective study comparing the frequency of contrast reactions by the rate of contrast injection is presented. One hundred patients undergoing excretion urography with meglumine diatriazoate (18%) and sodium diatriazoate (40%) mixture (Urografin 325) were randomised into slow (mean 0.975 ml/s) and rapid (mean 2.575 ml/s) injection groups. In the slow injection group 6 (12%) patients experienced a significant reaction as compared with 4 (8%) in the rapid injection group. There was no significant relationship between injection rate and contrast reaction (P greater than 0.1).
authors.affiliation: Department of Radiology, Queen Elizabeth Hospital, Edgbaston, Birmingham.
authors.forename: M J
authors.initials: MJ
authors.lastname: Duddy
authors.forename: R A
authors.initials: RA
authors.lastname: Manns
authors.forename: S A
authors.initials: SA
authors.lastname: Wormald
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011446:Prospective Studies; D011897:Random Allocation; D013997:Time Factors; D014567:Urography / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine