title: The cloning and sequence analysis of the rat serotonin-1A receptor gene.
abstract: Using a probe derived from the human 5-HT1A receptor gene (G-21), a strongly hybridizable clone was identified from a rat genomic DNA library. This clone (G21Y2) had an overall deduced amino acid sequence that was 88% homologous with that of the human 5-HT1A receptor. There was only an 18% and 19% amino acid homology with the rat 5-HT1C and 5-HT2 receptors, respectively. The G21Y2 appears to be an excellent candidate for the rat 5-HT1A receptor gene. As this manuscript was being prepared a report by Albert et al. (13) was published in which a probe to the hamster beta 2-adrenergic receptor was used to identify a rat genomic (Clone D) that demonstrated a sequence that was similar to G21Y2.
authors.affiliation: Department of Pharmacology, College of Medicine, University of Arizona, Tucson 85724.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: D L
authors.initials: DL
authors.lastname: Nelson
authors.forename: K
authors.initials: K
authors.lastname: Kashihara
authors.forename: E
authors.initials: E
authors.lastname: Varga
authors.forename: W R
authors.initials: WR
authors.lastname: Roeske
authors.forename: H I
authors.initials: HI
authors.lastname: Yamamura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D051381:Rats; D011985:Receptors, Serotonin / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011985:Receptors, Serotonin