title: Effect of strenuous exercise stress on chemiluminescence response of equine alveolar macrophages.
abstract: Bronchoalveolar lavage samples were collected using a fibreoptic endoscope from horses at specified times before and after single bouts of exercise. Lucigenin-dependent phagocytic chemiluminescence was used to assess the effect of exercise on the alveolar macrophage metabolic activity in response to stimulation by opsonised zymosan. A profound suppressive effect on the chemiluminescence production was present throughout the first three days after exercise. However, the cellular composition of lavage fluids was not altered by the exercise. It is suggested that strenuous exercise may jeopardize the antimicrobial function of alveolar macrophages which may lead to an increase in susceptibility to infection.
authors.affiliation: Department of Companion Animal Medicine and Surgery, University of Queensland, St Lucia, Australia.
authors.forename: C W
authors.initials: CW
authors.lastname: Wong
authors.forename: H L
authors.initials: HL
authors.lastname: Thompson
authors.forename: Y H
authors.initials: YH
authors.lastname: Thong
authors.forename: J R
authors.initials: JR
authors.lastname: Thornton
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology*; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D008163:Luminescent Measurements; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis; D005082:Physical Exertion; D013312:Stress, Physiological / Q000276:immunology / Q000662:veterinary*