Neutropenic enterocolitis. A new complication of head and neck cancer chemotherapy.
Neutropenic enterocolitis is a recognized complication of immunosuppression or chemotherapy for leukemia. It presents as severe abdominal pain and tenderness, fever, and diarrhea associated with granulocytopenia. Gastrointestinal symptoms associated with chemotherapy for head and neck neoplasms include nausea and emesis, but not acute abdominal distress. We present, to our knowledge, the first case of neutropenic enterocolitis in a patient receiving cisplatin and fluorouracil chemotherapy for metastatic head and neck cancer.
Petruzzelli
G J
GJ
Department of Otolaryngology, University of Pittsburgh, School of Medicine, Eye and Ear Institute, PA 15213.
Johnson
J T
JT
de Vries
E J
EJ
D000380:Agranulocytosis / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004760:Enterocolitis / Q000139:chemically induced*; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*
D002945:Cisplatin; D005472:Fluorouracil