title: Trisomy 12 in uterine leiomyomas. A new cytogenetic subgroup.
abstract: Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Nilbert
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: U M
authors.initials: UM
authors.lastname: Flodérus
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics*