Loracarbef concentrations in middle ear fluid.
Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean +/- standard deviation concentrations in MEF were 2.0 +/- 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 +/- 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.
Kusmiesz
H
H
Department of Otorhinolaryngology University of Texas, Southwestern Medical Center, Dallas 75235.
Shelton
S
S
Brown
O
O
Manning
S
S
Nelson
J D
JD
D001826:Body Fluids / Q000378:metabolism*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy; D014433:Tympanoplasty
D002511:Cephalosporins; C054920:loracarbef