Evidence that superior colliculi are involved in the control of amygdala-kindled seizures.
The effects of bilateral high radiofrequency lesions of superior colliculus (SC) were studied on amygdala kindling. The results demonstrate that a selective destruction of the SC only slightly facilitated the development of kindling. However, the most remarkable effect was the increase of afterdischarge and motor seizure duration observed when SC-lesioned animals reached the generalized seizures. These data confirm that the superior colliculi participate in controlling the generalization of kindled seizures.
N'Gouemo
P
P
Laboratoire de Médecine Expérimentale, INSERM U249, CNRS UPR41, Institut de Biologie, Montpellier, France.
Rondouin
G
G
D000679:Amygdala / Q000502:physiology / Q000503:physiopathology*; D000818:Animals; D004558:Electric Stimulation; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D013238:Stereotaxic Techniques; D013477:Superior Colliculi / Q000502:physiology / Q000503:physiopathology*