Prophylaxis of infection-induced kidney stone formation.
Lowering supersaturation with respect to struvite and carbonate apatite is the most important prophylactic measure in patients with infection-induced kidney stone disease. This is best achieved by combining culture-specific antibiotics with urinary acidification. Urinary infection with non-urease-producing Escherichia coli, probably promoting struvite particle formation, must be eradicated. Possible measures for improving urothelial anti-adherence properties or reducing bacterial adherence are discussed.
Hess
B
B
Policlinic of Medicine, University of Berne, Switzerland.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology / Q000517:prevention & control*; D014510:Urease / Q000037:antagonists & inhibitors; D014552:Urinary Tract Infections / Q000150:complications* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D014510:Urease