Erythropoietin: biological aspects and clinical usefulness.
In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the biological effects, the main pathophysiological aspects and the therapeutic usefulness of the hormone.
Liberato
N L
NL
Dipartimento di Medicina Interna e Terapia Medica, Policlinico S. Matteo, Pavia, Italy.
Costa
A
A
Barosi
G
G
D000595:Amino Acid Sequence; D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D004920:Erythropoiesis / Q000502:physiology; D004921:Erythropoietin / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000150:complications; D008099:Liver / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011087:Polycythemia Vera / Q000175:diagnosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D012636:Secretory Rate
D011994:Recombinant Proteins; D004921:Erythropoietin