title: Long-term remission of T-lymphoid extramedullary blast crisis of chronic myelogenous leukemia following allogeneic bone marrow transplantation.
abstract: Extramedullary blast crisis (EBC) with T-lymphoid phenotype has been reported rarely and generally associated with extremely poor prognosis. We describe a case of T-lymphoid EBC in which long-lasting remission was observed following intensive chemotherapy and allogeneic bone marrow transplantation (BMT). Characterization of bone marrow (BM) and lymph node (LN) cells was performed by means of morpho-cytochemical, cytogenetic, immunophenotypic and molecular analyses. These showed, together with a marrow picture consistent with typical Ph'+ chronic myelogenous leukemia, the expansion of an early T-lymphoid (CD7+/TdT+) LN cell population exhibiting the same bcr rearranged pattern and an additional Ph' chromosome. At the present time, 33 months after BMT, the patient is alive and well, with persistent clinical, hematological, cytogenetic and molecular evidence of complete remission.
authors.affiliation: Dipartimento di Biopatologia Umana, Università La Sapienza, Roma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Montefusco
authors.forename: F R
authors.initials: FR
authors.lastname: Mauro
authors.forename: F
authors.initials: F
authors.lastname: Lo Coco
authors.forename: B
authors.initials: B
authors.lastname: Rondinelli
authors.forename: W
authors.initials: W
authors.lastname: Arcese
authors.forename: A
authors.initials: A
authors.lastname: Tabilio
authors.forename: B
authors.initials: B
authors.lastname: Monarca
authors.forename: G
authors.initials: G
authors.lastname: Alimena
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D001752:Blast Crisis / Q000188:drug therapy / Q000601:surgery*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000473:pathology; D015461:Leukemia, Prolymphocytic, T-Cell / Q000188:drug therapy / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012074:Remission Induction; D014184:Transplantation, Homologous
chemical_list: D014408:Biomarkers, Tumor