title: Cephalexin concentrations in human serum, gingiva, and mandibular bone following a single oral administration.
abstract: 1. Cephalexin concentrations in human serum, gingiva, and mandibular bone after a single oral administration of cephalexin (500 mg) were measured by the paper disc method. 2. The peak times of serum, gingiva, and mandibular bone were approximately 90, 120 and 120 min, respectively. 3. The peak concentrations of serum, gingiva, and mandibular bone were 10.58 micrograms/ml, 5.57 micrograms/g and 2.12 micrograms/g, respectively. 4. The concentration ratio of gingiva/serum and mandibular bone/serum peak time of serum were 0.47 and 0.18, respectively. 5. Cephalexin concentrations in gingiva and mandibular bond did not exceed the MIC80s for clinically isolated strains of Staphylococcus aureus spp., alpha-Streptococci and Peptostreptococcus spp.
authors.affiliation: Second Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: A
authors.initials: A
authors.lastname: Uda
authors.forename: H
authors.initials: H
authors.lastname: Omata
authors.forename: J
authors.initials: J
authors.lastname: Shibutani
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Komiya
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: A
authors.initials: A
authors.lastname: Fujii
mesh_terms: D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002506:Cephalexin / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D008297:Male; D008334:Mandible / Q000378:metabolism; D008875:Middle Aged
chemical_list: D002506:Cephalexin