title: A hydrophilic plasma polymerized film composite with potential application as an interface for biomaterials.
abstract: A hydrophilic polymer composite film (approx. 420 nm thick), with potential application as an interface for biomaterials has been prepared on nonorganic substrates, which include glass, silicon, and aluminum foil, using a glow discharge plasma polymerization technique. A thin film (110 nm thick) polymerized from hexane provided an adherent protective coating for the substrate material, and covalent bonding sites for the outer layer polymerized from N-vinyl-2-pyrrolidone. This outer layer provided the hydrophilic surface or interface. The two layers were copolymerized for a short period during transition between monomers to provide an intimate covalently bonded diffuse interphase. Preliminary in vitro and in vivo biocompatibility studies indicate that the hydrophilic film is non-cytotoxic, and does not increase the inflammatory response when compared with negative controls.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
authors.forename: R E
authors.initials: RE
authors.lastname: Marchant
authors.forename: S D
authors.initials: SD
authors.lastname: Johnson
authors.forename: B H
authors.initials: BH
authors.lastname: Schneider
authors.forename: M P
authors.initials: MP
authors.lastname: Agger
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D006586:Hexanes; D008422:Materials Testing; D011108:Polymers; D011205:Povidone; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D006586:Hexanes; D011108:Polymers; D011205:Povidone