Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.
A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.
Nomoto
Y
Y
Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Japan.
Obase
H
H
Takai
H
H
Teranishi
M
M
Nakamura
J
J
Kubo
K
K
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D002316:Cardiotonic Agents; D010793:Phthalazines; D014227:Triazines; C043388:phthalazine