title: [Tolerance of gentacycol--a local dosage form of gentamicin based on collagen--animal experiments].
abstract: Gentacycol is a local dosage form of gentamicin based on collagen for implantation to wounds in treatment of patients with infections of soft tissues and prevention of contamination of open injuries of the bones and soft tissues. General toxic and organotropic properties of gentacycol were studied on animals with subcutaneous implantation of the dosage form in doses equivalent to the therapeutic dose for man and exceeding it 2-fold. The study showed that the dosage form had no unfavourable side effects on the animal general state, hearing, the functional state of the liver and kidneys and the peripheral blood. In the doses tested gentacycol did not influence the indices of the cardiovascular system and neuromuscular conduction. Morphological examination of the skin and hypodermic tissues in the implantation site revealed no damaging action of the dosage form on the surrounding tissues.
authors.affiliation: All-Union Research Institute of Antibiotics, Moscow.
authors.forename: G G
authors.initials: GG
authors.lastname: Egorenko
authors.forename: V V
authors.initials: VV
authors.lastname: Berezhinskaia
authors.forename: G V
authors.initials: GV
authors.lastname: Dolgova
authors.forename: T P
authors.initials: TP
authors.lastname: Svinogeeva
authors.forename: L A
authors.initials: LA
authors.lastname: Shtegel'man
authors.forename: E Z
authors.initials: EZ
authors.lastname: Kagan
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
mesh_terms: D000818:Animals; D003094:Collagen; D004343:Drug Implants; D005839:Gentamicins / Q000008:administration & dosage* / Q000633:toxicity; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D051381:Rats
chemical_list: D004343:Drug Implants; D005839:Gentamicins; D003094:Collagen
vernacular_title: Perenosimost' gentatsikola--mestnoĭ lekarstvennoĭ formy gentamitsina na osnove kollagena--v éksperimentakh na zhivotnykh.