[Prostacyclin and thromboxane synthesis in liver tissue in chronic liver diseases].
This paper reports on investigations of the formation of PGI2 and TXA2 using their stabile products 6-keto-PGF1 alpha and TXB2 (RIA) in liver biopsy specimens of 46 patients suffering from fatty liver (n = 19), chronic hepatitis B (n = 11), liver cirrhosis (n = 13), and miscellaneous diseases (n = 3). The measured formation rates in chronic liver disease were evaluated in comparison to a reference group (n = 19) consisting of minimal liver lesions. The 6-keto-PGF1 alpha formation correlating to the degree of the portal inflammation in the liver (morphometric evaluation). The same trend existed in relation to the intralobular inflammation. The results presented suggest in respect of analogous data in animal experiments that PGI2 is predominantly generated in mesenchymal cells of the liver and, presumably influences the course of liver diseases.
Zipprich
B
B
Klinik und Poliklinik für Innere Medizin, Bereichs Medizin, Martin-Luther-Universität Halle, Wittenberg.
Gerhardt
C
C
Giessler
C
C
Taube
C
C
Rath
F W
FW
Mest
H J
HJ
Nilius
R
R
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D002908:Chronic Disease; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis
D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol
Prostazyklin- und Thromboxansynthese im Lebergewebe bei chronischen Lebererkrankungen.