The antitumoral action of polyamine linked cyclophosphazenes on human malignant glioma heterografts in nu/nu mice.
Since the polyamine metabolism system is very active in proliferative glioma cells, polyamine linked drugs are to be considered as potential antineoplastic agents against malignant gliomas. This study reports the trial of a new compound lineage, the Polyamine Linked Cyclophosphazenes, on human glioblastoma heterografts in nu-nu mice. Two agents are tested: DIAM 3 and DIAM 4. Both show an important antineoplastic action either on a chronic treatment schedule or as single dose. Systemic tolerance is satisfactory.
Darcel
F
F
Labortoire de Neuropathologie, C.H.U., Rennes, France.
Chatel
M
M
Gautris
P
P
Labarre
J F
JF
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001388:Aziridines / Q000627:therapeutic use*; D002330:Carmustine / Q000627:therapeutic use; D002460:Cell Line; D002945:Cisplatin / Q000627:therapeutic use; D003959:Diamines / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D001388:Aziridines; D003959:Diamines; D009943:Organophosphorus Compounds; C064571:DIAM 3; C050390:DIAM 4; D002945:Cisplatin; D002330:Carmustine