title: Acute experimental osteomyelitis and abscesses: detection with MR imaging versus CT.
abstract: Acute experimental osteomyelitis and abscesses were induced in the proximal tibia and surrounding soft tissues, respectively, in 67 New Zealand white rabbits. Fifty-three rabbits were injected with a Staphylococcus aureus solution and 26, with sterile saline in tibial medullae and/or surrounding soft tissues. Contrast material-enhanced computed tomography (CT) and magnetic resonance (MR) imaging were performed 7 days after inoculation. Immediately after imaging, the animals were killed and necropsy was performed. MR imaging was more sensitive than CT in the detection of osteomyelitis (94% vs 66%, P less than .025) and abscesses (97% vs 52%, P less than .001). MR imaging was equally specific as CT in the exclusion of osteomyelitis (93% vs 97%, chi 2 = 0) but less specific than CT in the exclusion of abscesses (77% vs 100%, P less than .025). The overall accuracy of MR imaging was somewhat, although not significantly, greater than that of CT in the detection of both osteomyelitis (93% vs 80%) and abscesses (87% vs 75%).
authors.affiliation: Department of Radiology, Ohio State University, Columbus 43210.
authors.forename: V P
authors.initials: VP
authors.lastname: Chandnani
authors.forename: J
authors.initials: J
authors.lastname: Beltran
authors.forename: C S
authors.initials: CS
authors.lastname: Morris
authors.forename: S N
authors.initials: SN
authors.lastname: Khalil
authors.forename: C F
authors.initials: CF
authors.lastname: Mueller
authors.forename: J M
authors.initials: JM
authors.lastname: Burk
authors.forename: W F
authors.initials: WF
authors.lastname: Bennett
authors.forename: P B
authors.initials: PB
authors.lastname: Shaffer
authors.forename: M S
authors.initials: MS
authors.lastname: Vasila
authors.forename: J
authors.initials: J
authors.lastname: Reese
mesh_terms: D000038:Abscess / Q000175:diagnosis*; D000818:Animals; D008279:Magnetic Resonance Imaging; D009135:Muscular Diseases / Q000175:diagnosis*; D010019:Osteomyelitis / Q000175:diagnosis*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000175:diagnosis*; D013977:Tibia; D014057:Tomography, X-Ray Computed