Delayed auditory brainstem response in thiamin-deficient rats.
We recorded the auditory brainstem responses of rats fed a thiamin-deficient diet. The interpeak latencies between waves I and III, as well as those between waves I and IV, were significantly prolonged from day 24, while the latency of wave I was prolonged on day 26 of the thiamin-deficient diet. These delayed responses were corrected in 2 to 4 days after the initiation of daily intraperitoneal thiamin injections from day 32. The rats that were fed the thiamin-deficient diet, and then sacrificed on day 32, showed a decrease of total thiamin levels in the brain (26% of the level in control rat brains). Based on these results, we emphasize the value of the auditory brainstem response to detect thiamin deficiency.
Shigematsu
Y
Y
Department of Pediatrics, Fukui Medical School, Japan.
Nakai
A
A
Kuriyama
M
M
Kikawa
Y
Y
Konishi
I
I
Sudo
M
M
Itokawa
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism; D004032:Diet; D016057:Evoked Potentials, Auditory, Brain Stem; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000378:metabolism; D013832:Thiamine Deficiency / Q000175:diagnosis*
D013831:Thiamine