Changes in alveolar-arterial oxygen partial pressure difference during orthotopic liver transplantation.
Changes in the alveolar-arterial oxygen partial pressure difference (PAO2-PaO2) were measured in 39 patients undergoing orthotopic liver transplantation without veno-arterial or veno-venous bypass. The operation can be divided into an initial dissection phase, an anhepatic phase when the hepatic artery, portal vein and vena cava are clamped, and a post-anhepatic phase after the vascular clamps are released. There was an initial increase in (PAO2-PaO2) during the dissection phase, followed by an immediate decrease when the liver was removed. This decrease continued throughout the anhepatic period, but a further increase in (PAO2-PaO2) occurred after release of all the vascular clamps and during abdominal closure.
Burchett
K R
KR
Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
Smith
M F
MF
Park
G R
GR
D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood / Q000502:physiology*; D010313:Partial Pressure; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000032:analysis
D010100:Oxygen