title: Heparin-coated equipment reduces complement activation during cardiopulmonary bypass in the pig.
abstract: Complement activation was studied during cardiopulmonary bypass (CPB) in the pig. One group of animals was perfused for 2 h using a standard extracorporeal circuit including a hollow fiber membrane oxygenator with full systemic heparinization. Another group was treated in the same way, except that bypass was performed through a heparin-coated CPB circuit (Carmeda Bio-Active Surface, CBAS) and systemic heparinization was reduced by 75%. It was found that complement activation during CPB, measured as changes in the ratio C3d/C3, was significantly less in the CBAS group, most probably reflecting a better biocompatibility.
authors.affiliation: Department of Thoracic Surgery, University Hospital, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: K E
authors.initials: KE
authors.lastname: Storm
authors.forename: S
authors.initials: S
authors.lastname: Thelin
authors.forename: L
authors.initials: L
authors.lastname: Bagge
authors.forename: J
authors.initials: J
authors.lastname: Hultman
authors.forename: J
authors.initials: J
authors.lastname: Thorelius
authors.forename: U
authors.initials: U
authors.lastname: Nilsson
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015933:Complement C3d / Q000032:analysis; D006493:Heparin; D010107:Oxygenators, Membrane; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D003176:Complement C3; D015933:Complement C3d; D006493:Heparin