title: Early prognosis of supratentorial grade 2 astrocytomas in adult patients after resection or stereotactic biopsy. An analysis of 50 cases operated on between 1984 and 1988.
abstract: 50 adult supratentorial low-grade astrocytomas operated upon between 1984 and 1988 were analysed retrospectively with respect to postoperative condition and progression-free survival. Pilocytic lesions were excluded. In 32 instances the tumour was macroscopically completely removed and partially in 4. In 14 cases a stereotactic biopsy was performed only. 10 patients received postoperative radiotherapy with 55 to 65 Gy. 1 patient died perioperatively from pulmonary embolism. 39 patients could resume their previous activities after discharge from the hospital, 10 were significantly disabled by neurological deficit, reduced neuropsychological performance or medically intractable epilepsy. Postoperatively, most patients required continuous anti-epileptic medication, 10 recurrences or tumour progressions of incompletely removed or merely biopsied lesions were observed within the mean follow-up period of 22 months. All recurrences after gross total removal, that were reoperated, had progressed to a malignant glioma. Of the prognostic tumour characteristics analysed, a histologically well-delineated tumour demarcation was most clearly associated with a favourable prognosis. Concerning treatment modalities, gross total resection was associated with a favourable prognosis. Radiotherapy was associated with an unfavourable outcome but this is probably due to selection of otherwise unfavourable cases.
authors.affiliation: Department of Neurosurgery, University Hospital, Berne, Switzerland.
authors.forename: H J
authors.initials: HJ
authors.lastname: Steiger
authors.forename: R V
authors.initials: RV
authors.lastname: Markwalder
authors.forename: R W
authors.initials: RW
authors.lastname: Seiler
authors.forename: U
authors.initials: U
authors.lastname: Ebeling
authors.forename: H J
authors.initials: HJ
authors.lastname: Reulen
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D001706:Biopsy; D001925:Brain Damage, Chronic / Q000209:etiology; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D013238:Stereotaxic Techniques; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed