title: [Indices of the functional state of the hypothalamus-hypophysis-ovaries system in women with Itsenko-Cushing disease].
abstract: The content of gonadotropic hormones, prolactin and sex steroids were examined in the blood of 97 women with Itsenko-Cushing disease before and after administration of LH-RH and chorionic gonadotropin hormone. It was found that women with Itsenko-Cushing disease revealed a reduced concentration of gonadotropic hormones while the level of testosterone, progesterone, prolactin was increased. Estradiol remained unchanged. LH-RH tests indicate that women with Itsenko-Cushing disease revealed an abnormal synthesis and release of gonadotropins as well as secretion of LH-RH by the hypothalamus. The chorionic gonadotropin hormone test confirmed maintenance of the ovarian function.
authors.forename: R A
authors.initials: RA
authors.lastname: Manusharova
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin; D002908:Chronic Disease; D003480:Cushing Syndrome / Q000097:blood / Q000503:physiopathology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D010053:Ovary / Q000503:physiopathology*; D013997:Time Factors; D014626:Vaginal Smears
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone
vernacular_title: Nekotorye pokazateli funktsional'nogo sostoianiia sistemy gipotalamus--gipofiz--iaichniki u zhenshchin, bol'nykh bolezn'iu Itsenko--Kushinga.