title: [Effect of methylguanidine and guanidinosuccinic acid on pyruvate kinase activity in human red cells].
abstract: An effect of methylguanidine and guanidinosuccinic acid on pyruvate kinase activity in human red cells was determined in vitro following a 3-hour incubation at 37 degrees C. The obtained results have shown that methylguanidine in the concentration of 1.8 x 10(-5) M/l inhibits pyruvate kinase activity by 20.8%. Pyruvate kinase activity was statistically significantly inhibited on addition of methylguanidine in the concentration of 5.4 x 10(-5) M/l whereas higher concentrations have no such an effect Guanidinesuccinic acid exerted similar but weaker effect on the activity of pyruvate kinase in human red cells. Mixture of methylguanidine (5.4 x 10(-5) m/l) and guanidinesuccinic acid (2.8 x 10(-5) M/l) does not affect pyruvate kinase activity in normal human red cells under identical experimental conditions.
authors.affiliation: Zakładu Analityki Medycznej Katedry Onkologii, Karola Marcinkowskiego w Poznaniu.
authors.forename: Z
authors.initials: Z
authors.lastname: Kopczyński
authors.forename: T
authors.initials: T
authors.lastname: Dryl-Rydzyńska
authors.forename: K
authors.initials: K
authors.lastname: Baczyk
mesh_terms: D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008760:Methylguanidine / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
chemical_list: D006146:Guanidines; D013386:Succinates; D008760:Methylguanidine; C001318:guanidinosuccinic acid
vernacular_title: Wpływ metyloguanidyny i kwasu guanidynobursztynowego na aktywność kinazy pirogronianowej krwinek czerwonych człowieka.