Gangliosides improve synaptic transmission in dentate gyrus of hippocampal rat slices.
The effect of perfusion with gangliosides (1 x 10(-6) M) on the response evoked in the granule cell layer of dentate gyrus by stimulation of perforant path in hippocampal rat slices was studied. Gangliosides induced both a decrease in the frequency threshold of stimulation necessary to generate long-term potentiation (LTP) and greater potentiation than under control conditions. It is proposed that gangliosides improve the mechanisms responsible for synaptic plasticity which generate LTP.
Ramirez
O A
OA
Departmento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Gomez
R A
RA
Carrer
H F
HF
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005732:Gangliosides / Q000494:pharmacology* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats
D005732:Gangliosides