Calsequestrin, an intracellular calcium-binding protein of skeletal muscle sarcoplasmic reticulum, is homologous to aspartactin, a putative laminin-binding protein of the extracellular matrix.
Calsequestrin was isolated from chicken fast-twitch skeletal muscle, and partial amino terminal sequence was determined. The sequence (NH2) EEGLNFPTYDGKDRVIDLNE shows high identity with known mammalian calsequestrins contained in the Protein Identification Resource data bank (1). Most importantly, this 20 amino acid sequence shares complete identity with the amino terminus of aspartactin, a putative laminin-binding protein of the extracellular matrix (2, 3). The possible relationship of aspartactin to calsequestrin is discussed.
Yazaki
P J
PJ
Molecular Biology Institute, San Diego State University, Ca 92182.
Salvatori
S
S
Sabbadini
R A
RA
Dahms
A S
AS
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins / Q000032:analysis*; D002155:Calsequestrin / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D002645:Chickens; D005109:Extracellular Matrix / Q000032:analysis; D007797:Laminin / Q000378:metabolism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009124:Muscle Proteins / Q000032:analysis*; D012519:Sarcoplasmic Reticulum / Q000032:analysis
D002135:Calcium-Binding Proteins; D002155:Calsequestrin; D002352:Carrier Proteins; D007797:Laminin; D009124:Muscle Proteins; C057137:Casq1 protein, rat