title: Static and scanning array detection in capillary electrophoresis-mass spectrometry.
abstract: An array detection system based on position- and time-resolved ion counting was evaluated for capillary electrophoresis-mass spectrometry using continuous-flow fast atom bombardment and a liquid-junction coupling. Peptides with molecular masses up to 3200 were measured. A 100-1000-fold improvement over conventional detection was demonstrated by applying the array detector in scanning and static modes. Absolute detection limits in the range 1-5 fmol are achievable.
authors.affiliation: Division of Analytical Chemistry, Centre for Bio-Pharmaceutical Sciences, Leiden, The Netherlands.
authors.forename: N J
authors.initials: NJ
authors.lastname: Reinhoud
authors.forename: E
authors.initials: E
authors.lastname: Schröder
authors.forename: U R
authors.initials: UR
authors.lastname: Tjaden
authors.forename: W M
authors.initials: WM
authors.lastname: Niessen
authors.forename: M C
authors.initials: MC
authors.lastname: ten Noever de Brauw
authors.forename: J
authors.initials: J
authors.lastname: van der Greef
mesh_terms: D004586:Electrophoresis / Q000295:instrumentation / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008970:Molecular Weight; D001615:beta-Endorphin / Q000032:analysis
chemical_list: D001615:beta-Endorphin