[The effect of polyamines on lysosome fusion with phagosomes in mouse peritoneal macrophages].
The influence of polyamines on the phagosome-lysosome fusion in murine peritoneal macrophages and on polymerization of G-actin from the rabbit muscle in vitro has been studied. Both natural polyamines (spermin, spermidin, putrescin) and synthetic phenyl derivates of polyamines (3,3'-diaminobensidin, 1,5-naphtalin diamine, 4,4'-diaminodiphenilmetan, dancylcadaverin) were used. Unlike the phenyl derivates of polyamines and putrescin, spermin and spermidin stimulate the phagosome-lysosome fusion to induce G-actin polymerization. Possible mechanisms of action of the above polyamines are discussed.
Mozhenok
T P
TP
Bulychev
A G
AG
Braun
A D
AD
D000199:Actins / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D003599:Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects* / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D008561:Membrane Fusion / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008856:Microscopy, Fluorescence; D010529:Peritoneal Cavity / Q000166:cytology; D010588:Phagosomes / Q000187:drug effects* / Q000648:ultrastructure; D011073:Polyamines / Q000494:pharmacology*
D000199:Actins; D011073:Polyamines
Vliianie poliaminov na sliianie lizosom s fagosomami v peritoneal'nykh makrofagakh mysheĭ.