title: [A study of the inclusion complex of WB852 with beta-cyclodextrin].
abstract: The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with beta-cyclodextrin (beta-CD). The stability of WB852-beta-CD in aqueous solution was determined. The hydrolysis rate of WB852 from the inclusion compound was lower than that of WB852 alone. The solid inclusion compound of WB852 with beta-CD in 1:3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with beta-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA).
authors.affiliation: Shenyang College of Pharmacy.
authors.forename: S L
authors.initials: SL
authors.lastname: Wang
authors.forename: D S
authors.initials: DS
authors.lastname: Su
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Ji
mesh_terms: D003505:Cyclodextrins; D003517:Cyclopentanes; D004337:Drug Carriers; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D003517:Cyclopentanes; D004337:Drug Carriers; D047392:beta-Cyclodextrins; C067336:WB 852; C031215:betadex