Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.
Nagel
A A
AA
Department of Medicinal Chemistry, Pfizer Central Research, Groton, Connecticut 06340.
Rosen
T
T
Rizzi
J
J
Daffeh
J
J
Guarino
K
K
Nowakowski
J
J
Vincent
L A
LA
Heym
J
J
McLean
S
S
Seeger
T
T
D000818:Animals; D001667:Binding, Competitive; D006339:Heart Rate / Q000187:drug effects; D015394:Molecular Structure; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013844:Thiazoles