Intestinal absorption of vitamin E in experimental renal failure.
We studied intestinal absorption of vitamin E in rats with experimental renal failure (RF) and in sham-operated normal and pair-fed controls using in vivo perfusion and in vitro everted sacs. The in vivo absorption rates per unit of intestine length were significantly reduced in RF and pair-fed groups. Expression of data per unit of intestine weight gave normal values in the pair-fed but depressed values in the RF animals. Vitamin E uptake in vitro was significantly increased in RF animals, suggesting enhanced permeability. We conclude: (i) vitamin E absorption in vivo is impaired in experimental RF; (ii) this is in part due to reduced nutrient intake; and (iii) disparity between in vivo and in vitro results suggests the presence of some inhibitory influence(s) in intact animals with RF.
Pahl
M V
MV
Department of Medicine, University of California, Irvine Medical Center 92668.
Vaziri
N D
ND
Benavides
I
I
Khamiseh
G
G
Oveisi
F
F
D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D003404:Creatinine / Q000097:blood; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D014810:Vitamin E; D003404:Creatinine