Chemical structure of corticosteroids and its relationship with their acute induction of lordosis in the female rat.
The intravenous injection of several corticosteroids in the spayed estrogen-primed rat resulted, 5 min later, in a remarkable induction of lordosis response for deoxycorticosterone and 11-deoxycortisol. A lower but important effect was induced with corticosterone and 17 alpha-hydroxyprogesterone. A chemical structure-biological effect analysis showed that C-21 hydroxylation (e.g., deoxycorticosterone, 11-deoxycortisol, and corticosterone) induces the behavioral effect. However, C-11 or C-17 hydroxylation alone promotes the lordosis response to a lesser degree (corticosterone and 17 alpha-hydroxyprogesterone, respectively). However, the effect of these latter compounds is significant. From the results, it is concluded that deoxycorticosterone and 11-deoxycortisol along with other steroids such as 20 alpha-hydroxyprogesterone are suitable candidates for synergizing the well-known estrogen-progesterone induction of lordotic behavior.
Kubli-Garfias
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Unidad de Investigación Biomédica del CMN, México D.F. México.
D000305:Adrenal Cortex Hormones / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D003196:Computer Graphics; D005260:Female; D008958:Models, Molecular; D008968:Molecular Conformation; D011374:Progesterone / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013329:Structure-Activity Relationship
D000305:Adrenal Cortex Hormones; D011374:Progesterone