Influence of topical metal binding substances, vehicles, and corticosteroid creams on the allergic patch test reaction in metal-sensitive patients.
Persons known to be allergic to nickel, cobalt, or both were patch tested with serial dilutions of cobalt chloride or nickel sulfate either in petrolatum on skin treated with topical preparations with and without metal-binding compounds or incorporated into such special preparations. A decreased response was found in patients tested with Vioform (clinquinol) and cobalt chloride simultaneously, whereas rutin (3,3',4',5,7-pentahydroxyflavon 3-rhamnoglucosid) increased the response, and polyfloretin phosphate had no effect. The vehicles proved significant: "Ung Merck" and "W/O Cream Base" increased reactivity, whereas polyethylene glycol gave good protection against metal ions. As expected, corticosteroid creams suppressed the inflammatory response.
Fischer
T
T
Department of Occupational Dermatology, University Hospital, Uppsala, Sweden.
Rystedt
I
I
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D003035:Cobalt / Q000276:immunology* / Q000378:metabolism; D003879:Dermatologic Agents / Q000494:pharmacology*; D004643:Emollients / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D009532:Nickel / Q000276:immunology* / Q000378:metabolism; D010328:Patch Tests / Q000379:methods*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage*; D011092:Polyethylene Glycols; D012882:Skin Tests / Q000379:methods*
D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents; D004643:Emollients; D014677:Pharmaceutical Vehicles; D003035:Cobalt; D011092:Polyethylene Glycols; D009532:Nickel