Hospitalizations because of hypoglycemia in users of animal and human insulins. 2. Experience in the United States.
In a 10-year (1979-1988) follow-up study of young insulin-dependent diabetics carried out at Group Health Cooperative of Puget Sound, the frequency of hospitalization for hypoglycemia remained constant. During the early years only animal insulins were available; during the latter years, human insulins were used in a majority of patients. The adjusted relative risk estimate for hospitalizations for hypoglycemia comparing users of human with users of animal insulins was 0.6 (95% confidence interval 0.2, 2.3). We conclude that the use of human insulins is not associated with an increased risk of hospitalization for hypoglycemia as compared with animal insulins in this population.
Jick
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Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Massachusetts.
Derby
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Gross
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Jick
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D000818:Animals; D002423:Cause of Death; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology* / Q000401:mortality; D007328:Insulin / Q000009:adverse effects* / Q000145:classification; D014481:United States
D007328:Insulin