title: Early and late results of extended surgery for cancer of the stomach.
abstract: The experience of the Istituto Nazionale Tumori of Milan of 143 patients who underwent extended surgery for cancer of the stomach from 1965 to 1980 is reviewed. They represent 16.3 per cent of the patients who underwent curative surgery. The operative mortality rate was 15.4 per cent but this significantly decreased in recent years to 8 per cent and the morbidity rate to 17.5 per cent. The overall 5-year survival rate was 19 per cent. Survival was analysed according to tumour penetration (pT) and nodal status (N). It was found that patients without tumour penetration of adjacent structures and nodal involvement (pT3N-) had a better 5-year survival rate (21 per cent) than patients with nodal involvement (pT3N+) (2 per cent). Patients with tumour penetration of adjacent structures and without nodal involvement (pT4N-) had a better 5-year survival rate (29 per cent) than patients with nodal involvement (pT4N+) (5 per cent). These differences were significant on log rank test (P less than 0.000001 and P less than 0.001 respectively) and suggest that nodal status is a stronger prognostic variable than pT level. The role of extended surgery is discussed from the viewpoint of the oncological surgeon who has to weigh up the difficulty of a preoperative diagnosis of tumour infiltration of adjacent structures (predictive positive value 0.39), with the operative mortality rate of at least 8 per cent and long-term results which are strongly affected by the nodal status.
authors.affiliation: Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bozzetti
authors.forename: E
authors.initials: E
authors.lastname: Regalia
authors.forename: G
authors.initials: G
authors.lastname: Bonfanti
authors.forename: R
authors.initials: R
authors.lastname: Doci
authors.forename: D
authors.initials: D
authors.lastname: Ballarini
authors.forename: L
authors.initials: L
authors.lastname: Gennari
mesh_terms: D004067:Digestive System Neoplasms / Q000556:secondary / Q000601:surgery; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000556:secondary / Q000601:surgery; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate