A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis.
During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.
Mikami
Y
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Yu
S F
SF
Yazawa
K
K
Fukushima
K
K
Maeda
A
A
Uno
J
J
Terao
K
K
Saito
N
N
Kubo
A
A
Suzuki
K
K
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000737:chemistry / Q000633:toxicity; D002849:Chromatography, Gas; D006801:Humans; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D015394:Molecular Structure; D009615:Nocardia / Q000145:classification / Q000378:metabolism*; D009617:Nocardia Infections / Q000382:microbiology*; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D014407:Tumor Cells, Cultured
D001427:Bacterial Toxins