Acute cytogenetic effects of tyramine and MTCAs on mouse bone marrow cells in vivo by the micronucleus test.
We studied the acute cytogenetic effects of tyramine and MTCAs--precursors of the mutagen present in soy sauce--on mouse bone marrow cells in vivo by the micronucleus test. The incidence of MNPCE in bone marrow cells gradually increased and reached a maximum level 24 h after intraperitoneal injection of tyramine or MTCAs and decreased within 36 h. A dose-dependent increase in MNPCE was clearly observed for both compounds. Compared to the values for the untreated control, significant positive results were obtained with 0.5 mmole tyramine/kg (68.5 mg/kg) and with 0.1 mmole MTCAs/kg (23 mg/kg) 24 h after intraperitoneal administrations. Micronuclei were significantly induced but no severe reduction in the ratio of PCEs/NCEs was observed.
Fujie
K
K
Department of Natural Science, Osaka Women's University, Japan.
Nishi
J
J
Wada
M
M
Maeda
S
S
Sugiyama
T
T
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002243:Carbolines / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D009153:Mutagens; D013237:Stereoisomerism; D014439:Tyramine / Q000633:toxicity*
D002243:Carbolines; D009153:Mutagens; C038114:1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid; D014439:Tyramine