title: Reduced venous admixture in hemorrhagic hypovolemia: maintenance of arterial oxygenation by selective pulmonary vascular collapse.
abstract: In nine anesthetized and ventilated swine, a microcomputer calculated cardiac output, venous admixture (Qsp/Qt) and physiologic deadspace (VD/VT) every 20 sec, utilizing dual oximetry and a gas exchange analyzer. After lung injury with ethchlorvynol (ECV), animals were bled 40% blood volume over 40 min. Mean cardiac output decreased 7.0 to 2.2 L/min (p less than .05) accompanied by a decrease in mean Qsp/Qt from 0.28 to 0.14 (p less than .05) and an increase in mean VD/VT from 0.39 to 0.54 (p less than .05). Arterial Hgb saturation (Sao2) increased from 88 +/- 7% to 90 +/- 6%. On regression of all data points for each variable, Qsp/Qt had a positive correlation with cardiac output (r = .90), mean arterial pressure (MAP, r = .87), mean pulmonary artery pressure (MPAP, r = .86), and mixed venous Hgb saturation (Svo2, r = .89, p less than .001). VD/VT had an inverse correlation with cardiac output (r = -.90), MAP (r = -.82), Qsp/Qt (r = -.83), MPAP (r = -.77), and Svo2 (r = -.92, p less than .001). The decreasing Qsp/Qt and increasing VD/VT, with decreasing pulmonary perfusion pressures, were attributed to selective loss of perfusion to alveoli with low ventilation/perfusion ratios.
authors.affiliation: Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA.
authors.forename: G D
authors.initials: GD
authors.lastname: Kamal
authors.forename: T
authors.initials: T
authors.lastname: Symreng
authors.forename: D J
authors.initials: DJ
authors.lastname: Tatman
authors.forename: P J
authors.initials: PJ
authors.lastname: Jebson
mesh_terms: D000818:Animals; D004984:Ethchlorvynol / Q000506:poisoning; D008171:Lung Diseases / Q000139:chemically induced / Q000503:physiopathology*; D008838:Microcomputers; D008991:Monitoring, Physiologic; D010092:Oximetry; D012769:Shock / Q000503:physiopathology*; D013552:Swine
chemical_list: D004984:Ethchlorvynol