title: Influences of the cholecystokinin analog ceruletide on human sleep and evoked potentials.
abstract: Two experiments are reported, investigating the effects of the cholecystokinin analog ceruletide on central nervous activation in man. In experiment I, 0.55 micrograms/h ceruletide was infused at a constant rate during the night to study its effects on spontaneous EEG activity during sleep. In experiment II, we examined the effects of a bolus injection of ceruletide (0.5 micrograms) on components of the auditory evoked potential reflecting exogenously provoked central nervous arousal. While ceruletide had no effect on sleep, it attenuated stimulus-induced cortical arousal.
authors.affiliation: Angewandte Physiologie, Innere Medizin I, Universität Ulm, BRD.
authors.forename: R
authors.initials: R
authors.lastname: Pietrowsky
authors.forename: H L
authors.initials: HL
authors.lastname: Fehm
authors.forename: A
authors.initials: A
authors.lastname: Er
authors.forename: B
authors.initials: B
authors.lastname: Bathelt
authors.forename: J
authors.initials: J
authors.lastname: Born
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D002108:Ceruletide; D006854:Hydrocortisone