Bromide intoxication secondary to pyridostigmine bromide therapy.
The diagnosis of bromide intoxication is often aided by the detection of a low or negative anion gap due to the laboratory detection of bromide as chloride. A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. The diagnosis was suspected in the setting of a negative anion gap and only later confirmed by direct measurement of the serum bromide level. To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.
Rothenberg
D M
DM
Department of Anesthesiology, Rush-Presbyterian St-Luke's Medical Center, Chicago, IL 60612.
Berns
A S
AS
Barkin
R
R
Glantz
R H
RH
D001965:Bromides / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced / Q000209:etiology; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000506:poisoning*
D001965:Bromides; D011729:Pyridostigmine Bromide