title: The cutaneous microbiology of haired and hairless mice.
abstract: The cutaneous microflora of the mid-dorsal area of hairless and haired mice was studied by processing skin biopsies. In both C3H and CBA hairless genotype animals the prevalence of colonization and the bacterial density were significantly greater than in the haired animals. The dominant bacteria were staphylococci and aerobic coryneforms. No propionibacteria were isolated. Temporal studies with C3H mice showed that from 0 to 9 days after birth the cutaneous microflora reduced and from then on the haired genotype animals maintained a low cutaneous microflora, whilst hairless genotype animals gradually lost hair from head to tail and the microflora density increased. Reciprocal skin grafting between haired and hairless animals showed that the donor skin acquired the microflora characteristics of the recipient animal after 15 d post-grafting even though the donor skin remained morphologically true to genotype.
authors.affiliation: Department of Immunology, Leeds University, UK.
authors.forename: D
authors.initials: D
authors.lastname: Harnby
authors.forename: G
authors.initials: G
authors.lastname: Gowland
authors.forename: K T
authors.initials: KT
authors.lastname: Holland
authors.forename: J N
authors.initials: JN
authors.lastname: Kearney
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development*; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless / Q000382:microbiology*; D008809:Mice, Inbred C3H / Q000382:microbiology*; D008808:Mice, Inbred CBA / Q000382:microbiology*; D012867:Skin / Q000382:microbiology*