[The importance of the interpretation of autoantibodies: apropos of a case with anti-Ro antibodies during pregnancy].
Anti-Ro antibodies are autoantibodies which are directed against cytoplasmic and nuclear antigens. They are found in serum of patients suffering from Sjögren syndrome (70% of the cases) and systemic lupus erythematosus (SLE, about 20%). In SLE patients who are pregnant the anti-Ro antibodies are found in the serum of the newborn and have been associated with congenital heart block. We present here the case of a pregnant woman without clinical disease but with high titers of antinuclear, anti-RNP and anti-Ro antibodies. Pregnancy and delivery were uneventful and the three autoantibodies were found in the newborn's serum. We conclude that the presence of several autoantibodies, even in high titers and in a pregnant woman, should be interpreted with caution, in light of the clinical presentation.
Zufferey
C
C
Policlinique médicale universitaire, Lausanne.
Truscello
A
A
Pécoud
A
A
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001323:Autoantibodies / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D012261:Ribonucleoproteins; C035356:SS-A antibodies
Importance de l'interprétation des autoanticorps: à propos d'un cas avec anticorps anti-Ro pendant la grossesse.