The effect of intracerebroventricular insulin on the hypothalamic and neurohypophysial oxytocin activity in euhydrated or dehydrated rats.
Rats dehydrated up to four days were given intracerebroventricularly insulin in a daily dose of 100 ng. Insulin decreased significantly the hypothalamic and neurohypophysial oxytocin content in euhydrated rats. In dehydrated animals the oxytocin activity in the hypothalamo-neurohypophysial system, markedly depleted after deprivation of water, could be further reduced by intracerebroventricular treatment with insulin. These results seem to suggest a possible regulatory role of brain insulin in the mechanisms of oxytocin release.
Stempniak
B
B
Department of Pathophysiology, University School of Medicine, Lódź, Japan.
Guzek
J W
JW
D000818:Animals; D003681:Dehydration / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage*; D010121:Oxytocin / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D010121:Oxytocin