[The role of genetic and environmental factors in phenotypic variability of arterial pressure and body weight and their interconnection (a family study)].
Contribution of genetic and environmental factors into phenotypic variability of blood pressure and body mass as well as into phenotypic correlation between these traits was defined. It was shown that additive genetic determinant is responsible for considerable level of blood pressure and body mass variability. Those common environmental factors are of importance which operate within the limits of one generation. Maternal effect of systolic and diastolic blood pressure variability is negligible. The correlation between systolic and diastolic blood pressure is determined both by environmental and genetic factors, whereas that between blood pressure and body mass is mediated by only environmental factors. The contribution of environmental factors into correlation between blood pressure and body mass lessens with age. The results obtained may be applied in development of population and individual programmes for preventing cardiovascular diseases.
Rozanov
V B
VB
Aleksandrov
A A
AA
Belokon'
N A
NA
Koshechkin
V A
VA
Kabakova
V A
VA
Maslova
E R
ER
D001794:Blood Pressure / Q000235:genetics*; D001835:Body Weight / Q000235:genetics*; D002648:Child; D005190:Family; D006801:Humans; D008019:Life Style; D010641:Phenotype
Rol' geneticheskikh i sredovykh faktorov i fenotipicheskoĭ izmenchivosti arterial'nogo davleniia i massy tela i v ikh vzaimosviazi.