Synthesis of novel naphtho[2,1-b]-1,4,5-oxa- or thiadiazepines as potential antimicrobial and anticancer agents.
Two novel series of quinone derivatives have been synthesized. Thus, condensation of 2-ethoxycarbonylmethylthio-; 3-ethoxycarbonylmethylthio-2-methyl- and 3-ethoxycarbonylmethoxy-2-methyl derivatives of 1,4-naphthoquinone with substituted phenylhydrazines afforded the corresponding hydrazones, while cyclization of the same quinones with the same substituted hydrazines in glacial acetic acid gave the corresponding naphtho[2,1-b]-1,4,5-oxa- or thiadiazepine derivatives. The antimicrobial and anticancer activities of the synthesized compounds were studied.
Khalil
M A
MA
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
Habib
N S
NS
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001381:Azepines; D009281:Naphthalenes