title: High-performance liquid chromatography of globin chains in the identification of human globin gene abnormalities.
abstract: This article summarizes experience and data obtained using a previously developed reverse-phase high-performance liquid chromatography method (J.B. Shelton, J.R. Shelton and W.A. Schroeder, J. Liq. Chromatogr. 7 (1984) 1969) in the study of a number of hemoglobinopathies in the Sardinian population. The occurrence and incidence of several abnormal hemoglobins are described, as well as aspects of the expression of abnormal gamma-globin gene arrangements and thalassemic genes.
authors.affiliation: Istituto di Fisiologia Generale e Chimica Biologica, Università di Sassari, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Masala
authors.forename: L
authors.initials: L
authors.lastname: Manca
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002872:Chromosome Deletion; D015321:Gene Rearrangement; D005796:Genes; D014644:Genetic Variation; D005914:Globins / Q000235:genetics* / Q000302:isolation & purification; D006441:Hemoglobin A / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D046911:Macromolecular Substances; D009154:Mutation; D012016:Reference Values
chemical_list: D046911:Macromolecular Substances; D005914:Globins; D006441:Hemoglobin A