title: Circulatory support in infants with post-cardiopulmonary bypass left ventricular dysfunction using a left ventricular assist device.
abstract: Extracorporeal membrane oxygenation has been advocated as the most appropriate mode of circulatory support in the paediatric age group for post-cardiopulmonary bypass ventricular dysfunction. The results in infants who have predominantly left ventricular failure, or who require such support in order to be weaned off bypass, have been disappointing. Three infants with severe left ventricular dysfunction following cardiopulmonary bypass for correction of congenital heart defects have been managed with a left ventricular assist device. Two required this form of circulatory support in order to be weaned from full bypass while in the third infant it was instituted for progressive left ventricular dysfunction postoperatively. All three were less than 10 kg in weight. Left atrial appendage to aortic bypass was effected using a closed loop circuit with a constrained vortex pump (Biomedicus). Duration of support ranged between 40 and 146 h. One infant made a complete recovery and was able to be discharged home 20 days postoperatively. Another made a circulatory recovery such that both mechanical and inotropic support could be discontinued but had sustained massive neurological damage. The third died of progressive left ventricular dysfunction. This experience with a left ventricular assist device demonstrates that it is technically feasible in small infants, and can be performed to good effect in infants with predominant left ventricular dysfunction following cardiac surgery. It may well be more appropriate than extracorporeal membrane oxygenation in this group of patients.
authors.affiliation: Wessex Cardiothoracic Centre, Southampton General Hospital, UK.
authors.forename: N E
authors.initials: NE
authors.lastname: Moat
authors.forename: A
authors.initials: A
authors.lastname: Pawade
authors.forename: B C
authors.initials: BC
authors.lastname: Lewis
authors.forename: G
authors.initials: G
authors.lastname: Shore
authors.forename: R K
authors.initials: RK
authors.lastname: Lamb
authors.forename: J J
authors.initials: JJ
authors.lastname: Monro
mesh_terms: D002303:Cardiac Output, Low / Q000209:etiology / Q000628:therapy; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006353:Heart-Assist Devices; D006801:Humans; D007223:Infant; D008297:Male; D016277:Ventricular Function, Left