Triphenyltin: a potent excitatory neurotoxicant. Its reciprocal effects on voltage-dependent Na and K currents of mammalian brain neuron.
Effects of triphenyltin (TPT) on voltage-dependent sodium current (INa) and two respective potassium currents (delayed and transient potassium currents, IKD and IA) were examined on hippocampal neurons acutely isolated from Wistar rats using a conventional suction pipette technique. TPT at concentrations of 10(-7) to 10(-5) M increased the peak amplitude of INa associated with a prolongation of current decay. On the other hand, TPT started to reduce the peak amplitude of IA at 10(-7) M and completely suppressed it at 10(-5) M or less. The peak amplitude of IKD was also reduced by TPT at 10(-6) M or more. Results suggest that TPT possesses an excitatory neurotoxic action and that TPT as a possible environmental hazard may be harmful for human health.
Oyama
Y
Y
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Akaike
N
N
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D009474:Neurons / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology*; D009947:Organotin Compounds / Q000494:pharmacology*; D009994:Osmolar Concentration; D011188:Potassium / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000502:physiology*
D009498:Neurotoxins; D009947:Organotin Compounds; C030665:triphenyltin; D012964:Sodium; D011188:Potassium