Clastogenic effects of copper sulphate on the bone marrow chromosomes of mice in vivo.
Copper sulphate administered intraperitoneally to Swiss albino mice in vivo induced a significant increase in the frequency of chromosomal aberrations in bone marrow cells as all concentrations used (1.1-6.6 mg/kg b.w.), when compared to the negative control. Statistical analysis indicates that the degree of clastogenicity was directly related to the concentrations used and indirectly to the period of exposure. The effect was maximal at 6 h after treatment as compared with 12 and 24 h.
Agarwal
K
K
Department of Botany, University of Calcutta, India.
Sharma
A
A
Talukder
G
G
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D003300:Copper / Q000633:toxicity*; D019327:Copper Sulfate; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009153:Mutagens; D013223:Statistics as Topic; D013997:Time Factors
D009153:Mutagens; D003300:Copper; D019327:Copper Sulfate