Stability of plasma amiodarone levels during chronic oral therapy.
The variability of plasma amiodarone levels in 51 patients receiving chronic oral therapy over 4-53 (median 19) months was examined; 3-14 (median 5) plasma samples were obtained. After a loading dose, most patients received either 200 mg or 400 mg a day. Mean plasma amiodarone concentration was 1.2 +/- 0.6 mg/l and mean plasma desethylamiodarone concentration was 1.2 +/- 0.5 mg/l. No relationship was seen between height and weight and plasma concentrations. Dose was a significant predictor of plasma level (p less than 0.01) although it was a poor predictor of steady state amiodarone concentration.
Robinson
K
K
Cardiological Sciences, St. Georges Hospital, London, England.
Johnston
A
A
Walker
S
S
Mulrow
J
J
Holt
D
D
McKenna
W
W
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000638:Amiodarone