Improvement of the isolation-induced social behavioural deficit involves activation of the 5-HT1B receptors.
1. Mice were isolated for 7-9 days. An isolated mouse and a mouse reared in group showed a difference in their behaviour when observed together under an inverted beaker. The isolated mouse makes one half escape attempts in regard to the grouped mouse. This is considered as a social behavioural deficit. 2. 1- 3-(trifluoromethyl)phenyl piperazine (TFMPP), 1-(3-chlorophenyl)piperazine (m-CPP) and 5-methoxy-3 (1,2,3,6-tetrahydropyridin-4-yl) 1-H indole (RU-24969) activating preferentially the 5-HT1B receptors increased the number of escape attempts of the isolated mice up to the level of grouped mice. 3. Penbutolol, a beta-blocking drug acting also at 5-HT1 receptors, devoid of effect when given alone, antagonized significantly and dose-dependently the effects of TFMPP, m-CPP and RU-24969. 4. The interaction between TFMPP and five various serotonin antagonists was examined. Neither the 5-HT2 receptor antagonist ritanserine, the 5-HT3 receptor antagonist ICS 205-930, the 5-HT1C receptor antagonists mianserin and cyproheptadine antagonized the effect of TFMPP. The neuroleptic spiperone decreased by itself the number of escape attempts and opposed the TFMPP effect. 5. Taken together, these results suggest that the isolation-induced social behavioural deficit may be considered as a behavioural model responsive to 5-HT1B agonists.
Frances
H
H
Département de Pharmacologie et INSERM U-302, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Lienard
C
C
Fermanian
J
J
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010394:Penbutolol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012919:Social Behavior; D012934:Social Isolation; D013134:Spiperone / Q000494:pharmacology; D000077526:Tropisetron
D007211:Indoles; D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008803:Mianserin; C018406:1-(3-trifluoromethylphenyl)piperazine; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; D003533:Cyproheptadine; D013134:Spiperone; D000077526:Tropisetron; D010394:Penbutolol