title: The effect of oral metyrapone on aqueous humor dynamics in normal human eyes.
abstract: We studied the possible influence of oral metyrapone tartrate (which inhibits the adrenal biosynthesis of cortisol) on the rate of aqueous humor flow in 9 eyes of 8 normal subjects by fluorophotometry. On the control day, the mean value of Ko was 1.04 +/- 0.32 min-1 x 10(-2), where Ko was the loss coefficient from the anterior chamber. On the metyrapone trial day, the mean value of Ko was 0.63 +/- 0.15 min-1 x 10(-2). The mean difference in Ko between the two periods was significant (P less than 0.005). These results indicated that systemic metyrapone administration decreases the rate of aqueous humor flow.
authors.affiliation: Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mito
authors.forename: T
authors.initials: T
authors.lastname: Shiono
authors.forename: R
authors.initials: R
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Tamai
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008797:Metyrapone / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D006854:Hydrocortisone; D008797:Metyrapone