[Industrial production of monoclonal antibodies].
Murine monoclonal antibodies (mabs) are produced in either mouse ascites or bioreactors (spinner culture, stirred-tank reactor, airlift reactor, hollow-fiber reactor). Human mabs are produced solely in bioreactors. Encapsulation represents a special technology. Hybridoma cells have to be adapted prior to growth in bioreactors. Of crucial importance is the construction of over-producing cell lines by cell- and gene-technological methods. Manipulated cell lines often produce modified mabs.
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Boehringer Mannheim GmbH Fakultät für Biologie der Universität, Tübingen, Bundesrepublik Deutschland.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D001702:Biopharmaceutics; D005285:Fermentation; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D051379:Mice
D000911:Antibodies, Monoclonal
Industrielle Produktion monoklonaler Antikörper.