title: Effect of diazepam and medazepam on pentylenetetrazol kindling in albino rats.
abstract: Experiments on male albino rats were carried out in order to study the effects of diazepam and medazepam on the clonic-tonic convulsions in kindling phenomena evoked by multiple injections of a subconvulsive dose (40 mg/kg) pentylenetetrazol (PTZ). In the two doses used, both diazepam (0.25 and 1.0 mg/kg) and medazepam (2.0 and 5.0 mg/kg) manifest a marked anticonvulsive effect on the clonic-tonic convulsions in PTZ-kindled rats, with a marked dose-effect dependence. The evidence in the literature that the hippocampus plays the role of a pathologically determining structure in the realization of the PTZ kindling and that neurotransmission in the inhibitory synapses in the hippocampus is achieved by gamma-aminobutyric acid (GABA), gives grounds to accept that the anticonvulsive effects of diazepam and medazepam, observed in PTZ kindling, occur through GABA-ergic mechanisms, because the facilitating effect of benzodiazepines on the GABA-ergic neurotransmission is well known.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences.
authors.forename: M
authors.initials: M
authors.lastname: Lazarova-Bakarova
authors.forename: V V
authors.initials: VV
authors.lastname: Petkov
authors.forename: M
authors.initials: M
authors.lastname: Genkova-Papasova
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D008472:Medazepam / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008472:Medazepam; D003975:Diazepam; D010433:Pentylenetetrazole