title: Effect of vitamin E and selenium supplement on the aging peripheral neurons of the male Sprague-Dawley rat.
abstract: The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or high concentrations of selenium, whereas dietary concentration of vitamin E regulated age pigment content in the dorsal root ganglion, but not in the superior cervical and vagal ganglion. Vitamin E deficiency induced a three-fold increase in age pigment content in dorsal root ganglion at 8 months of age, whereas high vitamin E concentration was associated with a lesser amount of pigments at 18 months of age. Emission spectra of age pigment recorded from the dorsal root ganglion and vagal ganglion were different from that from the superior cervical ganglion, but were independent of dietary concentrations of selenium or vitamin E. The results suggest that exogenous antioxidants may play a more crucial role in lipid peroxidation and accumulation of age pigment in dorsal root ganglion than in autonomic ganglia.
authors.affiliation: Department of Public Health, University of Tampere, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Koistinaho
authors.forename: H
authors.initials: H
authors.lastname: Alho
authors.forename: A
authors.initials: A
authors.lastname: Hervonen
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000187:drug effects*; D000818:Animals; D005527:Food, Fortified; D008297:Male; D010525:Peripheral Nerves / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010860:Pigments, Biological; D014810:Vitamin E; D012643:Selenium