[Synthesis and analgesic activity of 4-N-propionyl analogs of 4-methoxycarbonyl fentanyl].
In the present paper, the synthesis and analgesic activities of some 4-N-propionyl analogs of 4-methoxycarbonyl fentanyl are reported. In mouse hot plate test, most of these compounds showed strong narcotic analgesic activity. The analgesic activities of compounds 1379, 1385 and 1387 were found to be more potent than that of 4-methoxycarbonyl fentanyl.
Lu
Z Y
ZY
Institute of Pharmaceutical Chemistry, PLA, Beijing.
Zhao
S Y
SY
Yuan
X M
XM
Yang
Y L
YL
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D051379:Mice
D000700:Analgesics; C017114:carfentanil; D005283:Fentanyl