title: Stressor induced variations of intracranial self-stimulation from the mesocortex in several strains of mice.
abstract: Intracranial self-stimulation (ICSS) from the mesocortex was assessed in BALB/cByJ, C57BL/6J and DBA/2J mice immediately, 24 h and again 168 h following stressor application. Stressor exposure failed to influence ICSS performance in C57BL/6J mice, while self-stimulation performance was reduced among BALB/cByJ mice only in the immediate post-stressor interval. In contrast, DBA/2J mice exhibited reduced rates of responding for brain stimulation at each of the post-stressor intervals. The potential contribution of DA alterations to the strain-dependent variations of ICSS performance induced by uncontrollable footshock are discussed.
authors.affiliation: Carleton University, Ottawa, Ontario, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Zacharko
authors.forename: W
authors.initials: W
authors.lastname: Gilmore
authors.forename: G
authors.initials: G
authors.lastname: MacNeil
authors.forename: M
authors.initials: M
authors.lastname: Kasian
authors.forename: H
authors.initials: H
authors.lastname: Anisman
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012653:Self Stimulation / Q000502:physiology*; D013045:Species Specificity; D013312:Stress, Physiological / Q000503:physiopathology*