Drug-associated aplastic anemia in dogs: eight cases (1984-1988).
Records of 8 dogs with drug-associated aplastic anemia were reviewed. Drugs suspected as being causative included estradiol cyclopentylpropionate (3 dogs), phenylbutazone (2 dogs), meclofenamic acid (1 dog), trimethoprim-sulfadiazine and fenbendazole (1 dog), and quinidine (1 dog). Five of the dogs died or were euthanatized. One dog with estrogen-associated aplasia recovered after prolonged treatment. The dogs with trimethoprim-sulfadiazine and quinidine-associated marrow aplasia recovered promptly after treatment was discontinued.
Weiss
D J
DJ
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Klausner
J S
JS
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects; D000962:Antimalarials / Q000009:adverse effects; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004338:Drug Combinations / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects; D005273:Fenbendazole / Q000009:adverse effects; D008469:Meclofenamic Acid / Q000009:adverse effects; D010653:Phenylbutazone / Q000009:adverse effects; D011802:Quinidine / Q000009:adverse effects / Q000031:analogs & derivatives; D012189:Retrospective Studies; D013411:Sulfadiazine / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects; D000096926:Benzenesulfonamides
D000890:Anti-Infective Agents; D000962:Antimalarials; D004338:Drug Combinations; D004967:Estrogens; D005273:Fenbendazole; D008469:Meclofenamic Acid; D010653:Phenylbutazone; D011802:Quinidine; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides; C016713:quinidine gluconate