[Modeling of torsion dystonia through electric stimulation of the vermis cerebellum cortex].
It was shown in acute experiments on cats that electrical stimulation (ES) (100-300 Hz, 5.0-10.0 V) of cat's cerebellar vermal cortex (lobules V and VI) was followed by head deviation in the direction opposite to that side on which the animal was laying, posture and movement disturbances and also by simultaneously occurred contraction of musculus-antagonists of extremities. The tonic and posture disturbances were observed during 40-60 s after ES cessation. During this time in the zone of ES in cerebellar cortex the high-amplitude synchronized activity was registered which was due to generator of pathologically enhanced excitation (GPEE) formation. Intraperitoneal diazepam (0.5-1.0 mg/kg, 30 min before the observation) pretreatment suppressed GPEE formation that correlated with suppression of syndrome manifestations. The conclusion was made that cerebellar hyperactive cortex, which was due to GPEE induction, might have played the role of pathological hyperactive determinant structure of the described syndrome.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
D000818:Animals; D002415:Cats; D002525:Cerebellar Cortex / Q000503:physiopathology*; D003975:Diazepam / Q000494:pharmacology; D004422:Dystonia Musculorum Deformans / Q000503:physiopathology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D008297:Male; D009119:Muscle Contraction; D011187:Posture; D013577:Syndrome
D003975:Diazepam
Modelirovanie torsionnoĭ distonii putem élektricheskoĭ stimuliatsii kory chervia mozzhechka koshek.