An evaluation of the acute in vivo toxicity of benzylidenechroman-4-ones, 1-thiobenzylidenechroman-4-ones and benzylidenetetralones.
A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.
Al-Nakib
T M
TM
Department of Pharmacology/Toxicology, Faculty of Medicine, Kuwait University.
Miller
N J
NJ
Rashid
S
S
Meegan
M J
MJ
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000633:toxicity; D001597:Benzylidene Compounds / Q000633:toxicity*; D002867:Chromones / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012727:Sex Characteristics
D000935:Antifungal Agents; D001597:Benzylidene Compounds; D002867:Chromones