Mononuclear cell infiltrate and HLA-Dr expression in 28 pituitary adenomas.
Frozen sections from 28 pituitary adenomas were reached with a panel of monoclonal antibodies to macrophages, lymphocytes and HLA-Dr invariant chain. A low number of macrophages were demonstrated in all tumors, mainly perivascular. CD8 and CD4 lymphocytes were detected in even smaller numbers in 80% and 14% of tumors respectively. B lymphocytes were present in only 1 case. An occasional NK cell was present in 1/13 cases studied. HLA-Dr antigen was expressed by macrophages in all cases and by tumor cells in 2 growth hormone-producing adenomas/19 adenomas. These findings may represent evidence for a low degree of cellular immune response to pituitary adenomas.
Rossi
M L
ML
Dept of Neuropathology, Radcliffe Infirmary, Oxford, U.K.
Jones
N R
NR
Esiri
M M
MM
Havas
L
L
al Izzi
M
M
Coakham
H B
HB
D000236:Adenoma / Q000276:immunology* / Q000473:pathology; D006683:HLA-DQ Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D010911:Pituitary Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens