Estrogen- and androgen-responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice.
A new line of human serous cystadenocarcinoma of the ovary, designated OVA-5, has been established in athymic nude mice. A strong correlation was noted between tumor volume and plasma CA125 levels in mice bearing OVA-5 tumor. Growth of the OVA-5 tumor in castrated male nude mice was accelerated by s.c. administration of estradiol-17 beta and 5 alpha-dihydrotestosterone but not by progesterone. Estradiol-17 beta and 5 alpha-dihydrotestosterone also accelerated the growth of the OVA-5 tumor heterotransplanted into sialoadenectomized castrated male nude mice. No remarkable change was observed in the histological appearances of the tumors between control groups and hormone-treated groups. Receptor assays revealed that the OVA-5 tumor had both estrogen and androgen receptors. Growth of the OVA-5-tumor is thus responsive to estrogen and androgen.
Sawada
M
M
Department of Obstetrics and Gynecology, Kure National Hospital, Japan.
Terada
N
N
Wada
A
A
Mori
Y
Y
Yamasaki
M
M
Saga
T
T
Endo
K
K
D000230:Adenocarcinoma / Q000473:pathology*; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D002369:Castration; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000473:pathology*; D014183:Transplantation, Heterologous
D000728:Androgens; D015295:Antigens, Tumor-Associated, Carbohydrate; D004967:Estrogens