A pharmacologic approach to dosage intensification.
Using standard pharmacologic concepts, it is possible to show that changes in schedule will influence the relative influx of drug between various normal tissues and tumor. A line of investigation is discussed that should lead to optimization of influx into tumor tissue while minimizing uptake into dose limiting normal tissues.
Weiss
A J
AJ
Department of Medicine, Thomas Jefferson School of Medicine, Philadelphia, PA.
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002470:Cell Survival / Q000187:drug effects; D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological
D000970:Antineoplastic Agents