[Effects of undecapeptide hydra morphogen on processes of cell division in the corneal and tongue epithelium of white rats].
We studied the effects of one and five time administration of peptide morphogen of hydra (PMH) in a dose of 10 micrograms/kg on cell division and DNA-synthesis in corneal and tongue epithelium of white rats. PMH stimulated cell proliferation considerably. This was revealed in acceleration of mitosis, and in rising of quantity of DNA-synthesis nuclei in 1.5-2.1 time after a single injection. In 24 hours after the five time administration the number of DNA-synthesis nuclei increased 1.5 and 1.9 time in corneal and tongue epithelium, correspondingly. This data reflects the possible role of PMH in structural homeostasis regulation.
Khomichuk
A Iu
AIu
Timoshin
S S
SS
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000166:cytology* / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006706:Homeostasis; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D013997:Time Factors; D014059:Tongue / Q000166:cytology* / Q000187:drug effects
D009479:Neuropeptides; C032522:head activator peptide; D004247:DNA; D011761:Pyrrolidonecarboxylic Acid
Vliianie undekapeptida morfogena gidry na protsessy kletochnogo deleniia v épitelii rogovitsy i iazyka belykh krys.