Transient focal neurologic deficits complicating interleukin-2 therapy.
We report 2 patients with transient, focal, repetitive, stereotyped episodes of neurologic deficits during treatment with interleukin-2. One patient had recurrent monocular blindness, while the 2nd had recurrent homonymous quadrantanopia. We suggest that these attacks are provoked by endothelial cell activation induced by interleukin-2.
Bernard
J T
JT
Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
Ameriso
S
S
Kempf
R A
RA
Rosen
P
P
Mitchell
M S
MS
Fisher
M
M
D001766:Blindness / Q000209:etiology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D014786:Vision Disorders / Q000209:etiology*
D007376:Interleukin-2