Effects of cis-diamminedichloroplatinum (CDDP) and cis-diammine (1,1-cyclobutanedicarboxylate) platinum (CBDCA) on thermotolerance development and thermosensitivity of the thermotolerant cells.
The interactive effects of combined treatment with heat and CDDP (0.5 micrograms/ml) or CBDCA (10 micrograms/ml) were examined on the surviving fractions of V-79 cells. Both CDDP and CBDCA treatment induced a slight enhancement in thermosensitivity of thermotolerant cells. The development of thermotolerance during step-up heating was partially inhibited by simultaneous treatment with CDDP or CBDCA throughout the heating process. Simultaneous heat treatment at 42 degrees C with either drug showed marked interactive effect and inhibited the thermotolerance developed during 42 degrees C heating.
Ohtsubo
T
T
Department of Otorhinolaryngology, Fukui Medical School, Japan.
Chang
S W
SW
Tsuji
K
K
Picha
P
P
Saito
H
H
Kano
E
E
D000818:Animals; D016190:Carboplatin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D002999:Clone Cells / Q000187:drug effects; D003131:Combined Modality Therapy; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy; D009944:Organoplatinum Compounds / Q000494:pharmacology*
D009944:Organoplatinum Compounds; C055423:didimethylsulfoxide dichloroplatinum(II); D016190:Carboplatin