[Catecholamine excretion in diabetics on insulin treatment].
In order to find out objective indices for "hidden" hypoglycemia in diabetic patients the urine excretion of the catecholamines adrenaline, noradrenaline, dopamine and the serum levels of cortisol and somatotrophic hormone (STH) were followed up. 45 diabetics on insulin treatment were included in the study: 32 patients with type I diabetes mellitus and 13 patients with diabetes mellitus type II with secondary resistance to sulfanilurea drugs and insulin. The patients were classified into the following groups: I. without hypoglycemia--28 patients; 2. with diurnal hypoglycemia--6 patients and 3. with nocturnal hypoglycemia--II patients. In the patients with hypoglycemia the 24 h adrenaline urine excretion was higher than in the patients without hypoglycemia. No such differences were found for noradrenaline and dopamine. The separate examination of the diurnal and nocturnal catecholamines excretion showed in all groups that they cannot serve as an objective index for determination of hypoglycemia. The STH showed no differences in all groups of diabetics. Disturbances in the circadian rhythm of cortisol secretion in diabetics were found. This could be a good and available marker for detecting "hidden" hypoglycemia in diabetics.
Koev
D
D
Ovcharova
N
N
Kamenova
P
P
Iankova
G
G
Lefterova
P
P
D000328:Adult; D015415:Biomarkers / Q000737:chemistry; D002395:Catecholamines / Q000652:urine*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000097:blood / Q000188:drug therapy / Q000652:urine; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D002395:Catecholamines; D007328:Insulin; D013006:Growth Hormone; D006854:Hydrocortisone
Katekholaminova ekskretsiia pri diabetno bolni na insulinolechenie.