Transient oliguria with renal tubular dysfunction after a 90 km running race.
In the course of a 19-d study of renal function in five ultramarathon runners, before, during and after a 90 km race, one runner developed transient oliguria with renal tubular dysfunction and anuria during and immediately after the race. Other features of the renal failure were an 84-fold increase in urine beta 2-microglobulin excretion (from 0.19 to 16.0 micrograms.min-1) and a much smaller increase in urine total protein excretion (from 0.07 to 0.18 mg.min-1) during the post-race period. Post-race creatinine clearance remained below pre-race levels throughout the study, varying between 42.8 and 72.9 ml.min-1, in contrast to the post-race 49% increase in the remaining runners (from 138.1 +/- 12.9 to 205.5 +/- 59.9 ml.min-1). Osmolal clearance also remained low (0.31 to 0.98 ml.min-1) compared with the pre-race values (1.46 +/- 0.02 ml.min-1), as did the urine flow rates (0.11 to 0.18 ml.min-1) compared with the pre-race values (0.34 +/- 0.02 ml.min-1). This renal dysfunction persisted despite the patient receiving 2 l of intravenous fluids immediately after the race and probably resulted from fluid restriction during the race. There was full recovery of renal function 1 yr later when the subject again ran the Comrades Marathon.
Irving
R A
RA
Department of Physiology and Medicine, University of Cape Town Medical School, Observatory, South Africa.
Noakes
T D
TD
Raine
R I
RI
Van Zyl Smit
R
R
D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D009846:Oliguria / Q000209:etiology* / Q000503:physiopathology; D010807:Physical Endurance; D011507:Proteinuria / Q000209:etiology; D012420:Running; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin