Nonstereoselective disposition of ethosuximide in humans.
The total concentration of ethosuximide varied between 80 and 770 mumol/L in plasma samples obtained from 33 patients on long-term treatment with the racemic drug. The ratios between the two enantiomers measured by chiral gas chromatography in the same samples were close to unity (mean +/- SD = 1.06 +/- 0.14; range = 0.76-1.39). This suggests that the disposition of ethosuximide in humans is not stereoselective and that the measurement of total concentrations of ethosuximide is sufficient for therapeutic monitoring.
Villén
T
T
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
Bertilsson
L
L
Sjöqvist
F
F
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002849:Chromatography, Gas; D005013:Ethosuximide / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D013237:Stereoisomerism
D005013:Ethosuximide