The effect of theophylline on estimated hepatic blood flow.
We observed the effect of aminophylline administration on estimated hepatic blood flow. Indocyanine green (ICG) 0.5 mg/kg was administered as an intravenous bolus dose before and after intravenous infusion of 7 mg/kg aminophylline. Venous blood was collected at timed intervals over 15 minutes to construct ICG concentration-time graphs. Pharmacokinetic values were calculated using non-compartmental methods. Estimated hepatic blood flow decreased from 790 +/- 190 to 665 +/- 100 ml/minute (p less than 0.05) after administration of aminophylline.
Kisor
D F
DF
Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261.
Wooding-Scott
R A
RA
D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008102:Liver Circulation / Q000187:drug effects*; D013997:Time Factors
D000628:Aminophylline; D007208:Indocyanine Green