title: Failure of surgery and isotretinoin to relieve jaw immobilization in fibrodysplasia ossificans progressiva: report of two cases.
abstract: Two patients with fibrodysplasia ossificans progressiva who presented with jaw immobilization due to formation of bone between the maxilla and mandible were treated with surgical resection of their ectopic bone in conjunction with experimental, adjunctive medical therapy using isotretinoin. Both patients had recurrence of their ectopic ossification within 2 months of surgery. Surgery to remove joint-bridging ossifications in FOP is not recommended.
authors.affiliation: National Institutes of Health, Bethesda, MD 20892.
authors.forename: L J
authors.initials: LJ
authors.lastname: Crofford
authors.forename: J S
authors.initials: JS
authors.lastname: Brahim
authors.forename: M A
authors.initials: MA
authors.lastname: Zasloff
authors.forename: J C
authors.initials: JC
authors.lastname: Marini
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007571:Jaw Diseases / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D009221:Myositis Ossificans / Q000188:drug therapy / Q000601:surgery*; D012008:Recurrence
chemical_list: D015474:Isotretinoin