title: Quantifying misclassification bias in cohort studies of vaccine efficacy.
abstract: A simple mathematical model is presented to quantify the bias due to misclassification in prospective cohort studies of vaccine efficacy. Limitations of methods based on quantifying misclassification in 2 x 2 tables are discussed. The model is applied to data from three examples of the design and analysis of studies of pertussis vaccine efficacy.
authors.affiliation: PHLS Communicable Disease Surveillance Centre, London, U.K.
authors.forename: C P
authors.initials: CP
authors.lastname: Farrington
mesh_terms: D000367:Age Factors; D015982:Bias; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004341:Drug Evaluation; D006801:Humans; D007223:Infant; D015233:Models, Statistical; D010567:Pertussis Vaccine; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine