Cytochrome P-450-linked monooxygenase systems of bovine brain mitochondria and microsomes.
1. Cytochrome P-450-linked monooxygenase of mitochondria and microsomes of the cerebrum, cerebellum and pituitary gland of bovine brain were investigated biochemically and immunochemically. 2. The cytochromes P-450scc and P-450(11) beta, NADPH-ferredoxin reductase and adreno-ferredoxin were detected and their enzymatic activities of steroid hydroxylations were found in the bovine brain.
Ohnishi
J
J
Division of Pharmacy, University Hospital, Faculty of Medicine, Kagawa, Japan.
Fukuoka
H
H
Nishii
Y
Y
Nakano
M
M
Ichikawa
Y
Y
D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D002417:Cattle; D002531:Cerebellum / Q000201:enzymology / Q000648:ultrastructure; D053493:Cholestanetriol 26-Monooxygenase; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005287:Ferredoxin-NADP Reductase / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology*; D010105:Oxygenases / Q000378:metabolism*; D010902:Pituitary Gland / Q000201:enzymology / Q000648:ultrastructure; D013252:Steroid 11-beta-Hydroxylase / Q000378:metabolism; D013250:Steroid Hydroxylases / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D013250:Steroid Hydroxylases; D053493:Cholestanetriol 26-Monooxygenase; D013252:Steroid 11-beta-Hydroxylase; D002786:Cholesterol Side-Chain Cleavage Enzyme; D005287:Ferredoxin-NADP Reductase