Influence of ethanol and serotonin on rat platelet aggregation.
We demonstrated that ethanol (1.0, 2.0 and 4.0 g/kg p.o.) significantly decreased blood platelet aggregation in a dose-dependent manner. The chronic administration of ethanol (6 g/kg daily for 4 weeks) also altered the sensitivity of rat platelets to ADP (4 mumol/l). We found that the acute and chronic administration of alcohol significantly increased the amplifying effect of 5-hydroxytryptamine (5-HT; 10(-6) mol/l) on ADP-induced aggregation. In all groups of rats, ketanserin (10(-5) mol/l) completely inhibited the amplification of aggregation induced by serotonin. In conclusion, the present results show that ethanol did not only produce inhibition of ADP-induced platelet aggregation but also affected the potentiating action of 5-HT on this process.
Chabielska
E
E
Department of Pharmacodynamics, Medical School, Bialystok, Poland.
Malinowska
B
B
Buczko
W
W
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology
D010975:Platelet Aggregation Inhibitors; D012701:Serotonin; D000431:Ethanol