Vasculitis with recurrent pulmonary hemorrhage in a long-term survivor after autologous bone marrow transplantation.
We report an unusual vasculitic syndrome in a long-term survivor of autologous bone marrow transplant. Clinical and pathologic studies revealed a cutaneous and pulmonary leukocytoclastic vasculitis complicated by recurrent pulmonary hemorrhage. Serologic studies revealed an elevated anti-neutrophil cytoplasmic antibody titer. The vasculitis has been successfully controlled with prednisone, cyclophosphamide, and trimethoprim/sulfamethoxazole.
Seiden
M V
MV
Division of Clinical Oncology, Dana-Farber Cancer Institute, Boston, MA.
O'Donnell
W J
WJ
Weinblatt
M
M
Licht
J
J
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000627:therapeutic use; D006470:Hemorrhage / Q000150:complications / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000209:etiology*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014295:Trimethoprim / Q000627:therapeutic use; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis / Q000209:etiology*
D003520:Cyclophosphamide; D014295:Trimethoprim; D013420:Sulfamethoxazole; D011241:Prednisone