1,3-disubstituted 2-thioxo-4,5-imidazolidinediones and 2,4,5-imidazolidinetriones and their anticonvulsant activity.
New unsymmetrically 1,3-disubstituted derivatives of 2-thioxo-4,5-imidazolidinedione (3, 5-7, 9-12) and 2,4,5-imidazolidinetrione (2, 8, 13-15) were synthesized by condensation of the respective thioureas and ureas with oxalyl chloride. They were screened for their central, mainly anticonvulsant activity and only compound 8 revealed antianxiety and antiepileptic properties.
Zankowska-Jasińska
W
W
Department of Organic Chemistry, Jagiellonian University, Kraków, Poland.
Borowiec
H
H
Kolasa
A
A
Ostrowska
K
K
Zaleska
B
B
Przemyk
B
B
Krzywosiński
L
L
Bogdal
M
M
Kieryłowicz
H
H
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004597:Electroshock; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D013055:Spectrophotometry, Infrared; D013871:Thiones / Q000138:chemical synthesis / Q000494:pharmacology
D000700:Analgesics; D000927:Anticonvulsants; D007093:Imidazoles; D013871:Thiones; D010433:Pentylenetetrazole