title: Albumin-adjusted calcium concentration in serum increases during normal pregnancy.
abstract: Concentrations of total calcium and albumin were measured in serum specimens from 41 women at intervals before, during, and after 42 pregnancies. The albumin concentration decreased but the calcium decreased more slowly, so that the albumin-adjusted calcium concentration increased from conception to term. These findings, taken in conjunction with published observations of hypercalciuria, increased concentrations of 1,25-dihydroxycholecalciferol and calcitonin in serum, and decreased concentrations of intact parathyrin in serum, strongly suggest that maternal ionized calcium increases throughout normal pregnancy.
authors.affiliation: Department of Chemical Pathology, St. James's University Hospital, Leeds, U.K.
authors.forename: R B
authors.initials: RB
authors.lastname: Payne
authors.forename: A J
authors.initials: AJ
authors.lastname: Little
authors.forename: R T
authors.initials: RT
authors.lastname: Evans
mesh_terms: D000328:Adult; D017317:Annexin A6; D002118:Calcium / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood; D005260:Female; D005306:Fertilization; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D012709:Serum Albumin / Q000032:analysis*; D013997:Time Factors
chemical_list: D017317:Annexin A6; D002135:Calcium-Binding Proteins; D012709:Serum Albumin; D002118:Calcium