Adrenal medulla transplantation into the putamen in Parkinson's disease.
Autologous adrenal medulla was transplanted into the putamen of a patient with severe Parkinson's disease. After the operation, the patient's akinesia and rigidity decreased and the duration of action of L-dopa treatment was prolonged. The effect lasted for only 6 months, however, following which the patient's condition gradually began to deteriorate again, returning to the preoperative state by 12 months after surgery. This paper discusses possible reasons why the effect was only temporary.
Takeuchi
J
J
Department of Neurosurgery, Utano National Hospital, Kyoto, Japan.
Takebe
Y
Y
Sakakura
T
T
Hara
Y
Y
Yasuda
T
T
Imai
T
T
D000313:Adrenal Medulla / Q000637:transplantation*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery*; D011699:Putamen; D016042:Transplantation, Heterotopic
D007980:Levodopa