Pharmacokinetics and adverse effects of single doses of dothiepin in young and elderly subjects.
1. The pharmacokinetics and side-effects of Dothiepin (DOT) were studied for four days after administration of a single oral dose of 75 mg to young adult and elderly subjects. 2. In the elderly DOT is absorbed, distributed and eliminated with half-lives about the same as in young adults but it is cleared less efficiently. 3. This difference of clearance in the elderly, after single-dose administration, is not reflected in increased incidence of side-effects.
Bareggi
S R
SR
Department of Pharmacology, School of Medicine, State University, Milan, Italy.
Cavallaro
R
R
Pirola
R
R
Altamura
A C
AC
D000328:Adult; D000367:Age Factors; D000368:Aged; D003988:Dibenzothiepins / Q000493:pharmacokinetics*; D004308:Dothiepin / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
D003988:Dibenzothiepins; D004308:Dothiepin