Effect of NO2 on lipids and lipid peroxidation in the CNS of the guinea-pig.
This study was undertaken to investigate the effect of nitrogen dioxide on some neurochemical parameters. Guinea-pigs were exposed to NO2, 5 p.p.m. and 10 p.p.m. for 2 hr daily for five weeks. The results showed significant depletion of the total lipids and phospholipids content of the cerebral hemisphere, cerebellum, midbrain and spinal cord following nitrogen dioxide intoxication. The results further revealed significant diminution in the cholesterol content of the NO2 intoxicated animals in cerebral hemisphere, cerebellum and midbrain. But on the other hand the level was significantly enhanced in the spinal cord. Interestingly, the rate of lipid peroxidation was found enhanced in all the investigated brain areas, and with increasing dosage the effect was correspondingly pronounced.
Farahani
H
H
Interdisciplinary Brain Research Center, J. N. Medical College, Aligarh Muslim University, India.
Hasan
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D006168:Guinea Pigs; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*
D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol; D009609:Nitrous Oxide