The effect of pentamidine salts on the NADPH-dependent oxidase of stimulated neutrophilic granulocytes.
Both pentamidine isethionate and pentamidine mesylate induced a depression in activity of the NADPH-dependent oxidase system of stimulated human neutrophilic granulocytes. This drug-induced effect occurred at concentrations of 0.7, 1.1 and 1.5 mg/l, values within the therapeutic range after parenteral administration of a standard dose of either pentamidine salt, and was dose-related. There was no significant difference between the two salts with regard to this suppression in neutrophilic granulocyte function. The reduced activity of the NADPH-dependent oxidase system, after incubation with pentamidine salts, may be associated with the previously observed depression in candidacidal capacity of human neutrophilic granulocytes treated with these drugs.
Arnott
M A
MA
Department of Microbiology, University Leicester, UK.
Hay
J
J
D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D010419:Pentamidine / Q000008:administration & dosage / Q000494:pharmacology*
D010419:Pentamidine; D009247:NADH, NADPH Oxidoreductases