title: Chromosomal organization of the amplified esterase B1 gene in organophosphate-resistant Culex pipiens quinquefasciatus Say (Diptera, Culicidae).
abstract: In Culex pipiens quinquefasciatus from California, high resistance to organophosphorus insecticides is due to an increased production of the detoxifying esterase B1 resulting from a 250-fold amplification of the structural gene. The chromosomal organization of this amplified gene was studied by in situ hybridization techniques. Esterase B1 gene copies were found to be clustered on a single chromosome, tentatively identified as chromosome II.
authors.affiliation: Institut des sciences de l'évolution, Université de Montpellier II, France.
authors.forename: E
authors.initials: E
authors.lastname: Nance
authors.forename: D
authors.initials: D
authors.lastname: Heyse
authors.forename: J
authors.initials: J
authors.lastname: Britton-Davidian
authors.forename: N
authors.initials: N
authors.lastname: Pasteur
mesh_terms: D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000235:genetics* / Q000378:metabolism; D002875:Chromosomes / Q000648:ultrastructure*; D003465:Culex / Q000201:enzymology / Q000235:genetics*; D005784:Gene Amplification; D005796:Genes; D007305:Insecticide Resistance / Q000235:genetics; D007306:Insecticides / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D009943:Organophosphorus Compounds
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D002265:Carboxylic Ester Hydrolases