[Functional and morphological characterization of alveolar macrophages from patients with pulmonary sarcoidosis].
Bronchoalveolar lavage was performed in 28 patients with pulmonary sarcoidosis. Enzyme cytochemical staining with the tartrate-resistant acid phosphatase revealed a significantly increased portion of sarcoidosis macrophages showing a monocyte-like phenotype. Immunocytochemical staining with the proliferation-associated monoclonal antibody Ki-67 showed an increase of proliferating monocyte/macrophages related to disease activity in sarcoidosis. A functional activation of alveolar macrophages in sarcoidosis is indicated by spontaneous interleukin-1 secretion and increased release of oxygen free radical in sarcoidosis alveolar macrophages.
Barth
J
J
I. Medizinische Klinik der Universität Kiel.
Petermann
W
W
Kreipe
H
H
Radzun
H J
HJ
Parwaresch
M R
MR
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002455:Cell Division; D005609:Free Radicals; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000096:biosynthesis; D008171:Lung Diseases / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D010084:Oxidation-Reduction; D012507:Sarcoidosis / Q000276:immunology*
D005609:Free Radicals; D007375:Interleukin-1
Funktionelle und morphologische Charakterisierung von Alveolarmakrophagen bei Patienten mit pulmonaler Sarkoidose.