Blood pressure changes induced by ciclosporin A in type I diabetes.
The determinants of ciclosporin A-induced blood pressure changes were analyzed initially and after 3 months in 30 recent type I diabetics submitted to chronic treatment with ciclosporin as single immunosuppressive drug. Prevalence of hypertension was 17% and relatively low as compared to those reported in organ transplantation. Ciclosporin induced a slight decrease in glomerular filtration rate and renal plasma flow, with unchanged filtration fraction, a mild average increase in blood pressure and a more pronounced increase in renal vascular resistance. There was a trend toward decrease in absolute urinary sodium excretion whereas fractional excretion of sodium was unchanged. Presence of familial history of essential hypertension was characterized by a slightly insignificantly lower renal plasma flow and did not affect the renal effect of ciclosporin except that the renal plasma flow was significantly lower in the groups of patients genetically predisposed.
Hannedouche
T
T
Département de Néphrologie, Hôpital Necker, Paris, France.
Choukroun
G
G
Delgado
A
A
Boitard
C
C
Lacour
B
B
Grünfeld
J P
JP
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D005919:Glomerular Filtration Rate; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007677:Kidney Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D015995:Prevalence
D003524:Cyclosporins; D007166:Immunosuppressive Agents