De novo Ph negative T-cell lymphoblastic leukaemia associated with bcr gene rearrangement.
One case of de novo Ph-negative T-cell acute lymphoblastic leukaemia has been found to have a classical breakpoint cluster region (bcr) rearrangement of the type seen in chronic granulocytic leukaemia. There were no haematological features to suggest a previous chronic phase. This case represents the first report of this rearrangement in Ph negative acute T-lymphoblastic leukaemia at presentation. The implications for various therapeutic options in such patients are discussed.
Middleton
P G
PG
Department of Haematology, University of Newcastle upon Tyne, England.
Davison
E V
EV
Reid
M M
MM
Proctor
S J
SJ
D000328:Adult; D015139:Blotting, Southern; D002892:Chromosomes, Human, Pair 22; D015321:Gene Rearrangement; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D005810:Multigene Family; D009857:Oncogenes; D010677:Philadelphia Chromosome