Quinine hepatotoxicity. An underrecognized or rare phenomenon?
Quinine-induced hepatic injury has been reported very rarely. We report a case involving a patient with an apparent hypersensitivity to quinine, manifested by a clinical syndrome mimicking a viral illness and a mixed hepatocellular-cholestatic liver injury pattern. We briefly review the unusual literature on this topic, which features many cases of hypersensitivity to the optical isomer of quinine, quinidine; yet, to our knowledge, there has only been one prior report of quinine hepatotoxicity.
Punukollu
R C
RC
Department of Medicine, Cleveland Metropolitan General Hospital, Case Western Reserve University, Ohio.
Kumar
S
S
Mullen
K D
KD
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004796:Clinical Enzyme Tests; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D011803:Quinine / Q000009:adverse effects*
D011803:Quinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase