title: [Circulatory changes in the rat tibia in dietary calcium and vitamin D deficiency. Effects of age and sex].
abstract: In previous experiments (4) we observed in laboratory rats after a low Ca content diet with no vitamin D a decrease of blood flow through bones. In this study we follow whether the effect of the deficit diet is influenced by age or sex of experimental animals. Tibia blood flow in rats is established by 85Sr-microparticles, bone density is estimated by weighing the bone under water. After 10 days of feeding by the deficit diet 85Sr-microparticles catchment in young males is decreased to 74% of that of controls, in young females to 61%, blood flow is decreased to 46% and 51% respectively. In older males after the diet the microparticles catchment is significantly decreased to 63%, blood flow is non-significantly decreased to 82% (as a result of higher cardiac output). In the category of older females the effect of deficient diet is not demonstrable as regards both microparticles catchment and blood flow. Bone density in preliminary experiment after 40 days of diet is significantly decreased in males of both age categories and in young females, in the main experiment after 10 days of diet it is decreased only in the categories of young males and females. From the results obtained in following the effect of diet deficient in Ca and vitamin D on density and local blood flow in tibia of rats can be concluded 1) that in this respect younger rats are more susceptible, 2) in the category of older males the effect is partly demonstrable in males, but not in females.
authors.affiliation: Laborator pro endokrinlogii a metabolismus a III. interní klinika fakulty vseobecného lékarství Univerzity Karlovy, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Kapitola
authors.forename: I
authors.initials: I
authors.lastname: Jahoda
authors.forename: M
authors.initials: M
authors.lastname: Stĕpánková
mesh_terms: D000367:Age Factors; D000818:Animals; D015519:Bone Density / Q000502:physiology; D002118:Calcium / Q000172:deficiency*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002196:Capillaries / Q000503:physiopathology; D005260:Female; D007511:Ischemia / Q000209:etiology*; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D012737:Sex Factors; D013977:Tibia / Q000098:blood supply*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000503:physiopathology
chemical_list: D002136:Calcium, Dietary; D002118:Calcium
vernacular_title: Obĕhové zmĕny v holenní kosti potkanů pri deficitu kalcia a vitaminu D v potravĕ. Vliv stárí a pohlaví.