Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
The effects of prostaglandin synthesis inhibitors on development of N-nitrosobis(2-oxopropyl)amine (BOP)-initiated pancreatic tumors were investigated. Female Syrian golden hamsters were given five weekly s.c. injections of BOP (10 mg/kg body weight) during the first 5 weeks and then given 20 p.p.m. indomethacin in the drinking water, 0.25% phenylbutazone in the diet, 1% aspirin in the diet, or no treatment (control group). The resultant incidence of pancreatic carcinoma at week 32 was significantly lower (P less than 0.05) in animals receiving phenylbutazone (36.8%) than in the controls (71.4%) and the numbers of carcinomas per hamster were significantly reduced by indomethacin (0.63) and phenylbutazone (0.58) treatment compared with the control group value (1.29). Aspirin also showed a tendency to decrease pancreatic tumor incidence, but this was not significant. Thus, prostaglandin synthesis inhibitors reduce the development of pancreatic cancer when administered during the post-initiation phase in this animal model.
Takahashi
M
M
Department of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Furukawa
F
F
Toyoda
K
K
Sato
H
H
Hasegawa
R
R
Imaida
K
K
Hayashi
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000517:prevention & control*; D010195:Pancreatitis / Q000150:complications; D010653:Phenylbutazone / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin