Effect of nicardipine on the cardiovascular response to tracheal intubation.
We studied the cardiovascular responses to laryngoscopy and intubation in 30 patients who received nicardipine 15 micrograms kg-1 or 30 micrograms kg-1, or saline placebo 60 s before the start of laryngoscopy. Anaesthesia was induced with thiamylal 5 mg kg-1 i.v. and tracheal intubation was facilitated with vecuronium 0.2 mg kg-1. Patients receiving saline showed a significant increase in mean arterial pressure (MAP) and rate-pressure product (RPP) associated with tracheal intubation. The increases in MAP and RPP following tracheal intubation were reduced in both groups of patients who received nicardipine.
Mikawa
K
K
Department of Anaesthesiology, Kobe University School of Medicine, Japan.
Obara
H
H
Kusunoki
M
M
D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D006801:Humans; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D009529:Nicardipine / Q000494:pharmacology*
D009529:Nicardipine