title: Prolonged labetalol infusion for management of severe hypertension and tachycardia in a critically ill trauma patient.
abstract: A trauma victim sustained multiple injuries including cervical spine injuries, splenic laceration, and left kidney fracture. His recovery was complicated by acute renal failure, resistant hypertension, and tachycardia refractory to multiple therapies. The patient was ultimately managed with continuous infusions of labetalol 2-3 mg/min for 14 days, with adequate control of both blood pressure and heart rate. The sustained labetalol infusion was not associated with clinically significant adverse effects although a progressive decrease in heart rate was noted near the end of therapy. This downward trend in heart rate was not associated with hemodynamic compromise and returned to pretreatment baseline of 90-110 beats/min upon discontinuation of parenteral therapy and initiation of oral labetalol. The prolonged use of labetalol infusions may be beneficial in certain patients. Further work needs to be done to identify the safety and efficacy of labetalol infusions.
authors.affiliation: Department of Surgery, A.B. Chandler Medical Center, College of Pharmacy, University of Kentucky, Lexington 40536.
authors.forename: T L
authors.initials: TL
authors.lastname: Goldsmith
authors.forename: D E
authors.initials: DE
authors.lastname: Barker
authors.forename: W E
authors.initials: WE
authors.lastname: Strodel
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003422:Critical Care; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007262:Infusions, Intravenous; D007741:Labetalol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013610:Tachycardia / Q000188:drug therapy* / Q000503:physiopathology; D014947:Wounds and Injuries / Q000503:physiopathology / Q000628:therapy*
chemical_list: D007741:Labetalol