title: Genetic-epidemiologic study of haemophilia A and B in Hungary.
abstract: All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western countries of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10,000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10(-5) for haemophilia A and 0.2 x 10(-5) for haemophilia B.
authors.affiliation: Department of Blood Transfusion, Markusovszky Hospital of County Vas, Szombathely.
authors.forename: L
authors.initials: L
authors.lastname: István
authors.forename: A
authors.initials: A
authors.lastname: Czeizel
authors.forename: M
authors.initials: M
authors.lastname: Kerényi
authors.forename: A M
authors.initials: AM
authors.lastname: Tóth
authors.forename: E
authors.initials: E
authors.lastname: Domby
mesh_terms: D005193:Family Planning Services / Q000706:statistics & numerical data*; D006580:Genetic Carrier Screening; D005828:Genetics, Population; D006467:Hemophilia A / Q000453:epidemiology* / Q000235:genetics; D002836:Hemophilia B / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D009154:Mutation; D015995:Prevalence