[Kinetics of the transformation of dihydroambazone into ambazone].
The oxidation of dihydroambazone (1) by oxygen is dependent on the pH-values of the solutions used. This transformation can be inhibited and excluded, respectively, by ascorbic acid using defined concentrations. The oxidation product ambazone (2) was determined spectroscopically at different pH-values. The rate of transformation in serum depends on the temperature and can also be inhibited with ascorbic acid.
Miosga
N
N
Akademie der Wissenschaften der DDR.
Roemer
W
W
Amlacher
R
R
D000818:Animals; D001205:Ascorbic Acid; D001711:Biotransformation; D006863:Hydrogen-Ion Concentration; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D010084:Oxidation-Reduction; D051381:Rats; D013696:Temperature
C058853:dihydroambazone; C037931:1,4-benzoquinone guanylhydrazone thiosemicarbazone; D008935:Mitoguazone; D001205:Ascorbic Acid
Kinetik der Umwandlung von Dihydroambazon in Ambazon.