Topical nonsteroidal agents and corneal wound healing.
The effects on corneal wound healing of two topical nonsteroidal anti-inflammatory agents, flurbiprofen sodium (0.03%) and diclofenac sodium (0.1%), and the topical corticosteroid, prednisolone sodium phosphate (1%), were evaluated in masked, controlled rabbit studies. Healing of epithelial scrape wounds was significantly retarded in all three treatment groups for the first 3 days after wounding. There was no difference in the epithelial healing rate between the two nonsteroidal or corticosteroid treatment groups. Clinical grading of epithelial quality, conjunctival hyperemia, keratitis, stromal edema, and corneal haze were similar in all groups. There was a significant early decrease in the iritis score in the diclofenac treatment group. The strength of 2-mm central penetrating corneal trephination wounds and the collagen content of these wounds were similar in all groups. Both the topical nonsteroidal anti-inflammatory agents and the corticosteroid used in the preparations and dosages investigated in this study decreased early epithelialization of scrape wounds but had no apparent effect on corneal stromal healing. No toxic effects of the various drugs were found.
Hersh
P S
PS
Hilles Immunology Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114.
Rice
B A
BA
Baer
J C
JC
Wells
P A
PA
Lynch
S E
SE
McGuigan
L J
LJ
Foster
C S
CS
D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D015715:Corneal Edema / Q000473:pathology; D065306:Corneal Injuries; D003319:Corneal Stroma / Q000187:drug effects / Q000293:injuries / Q000502:physiology / Q000648:ultrastructure; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004848:Epithelium / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006909:Hydroxyproline / Q000378:metabolism; D006940:Hyperemia / Q000473:pathology; D007500:Iritis / Q000473:pathology; D007634:Keratitis / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D004008:Diclofenac; D005480:Flurbiprofen; D003094:Collagen; D011239:Prednisolone; D006909:Hydroxyproline