Effects of repeated administration of soman on schedule-controlled behavior and brain in the rat.
The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marked tolerance to repeated drug administration. Response rates generally recovered to baseline levels within 1-3 sessions. Three of the six animals studied, however, demonstrated marked deterioration of steady state schedule performance, particularly during the FI 50-sec component of the multiple schedule. Compared to untreated controls, all soman-treated animals exhibited pathological changes in brain. The most salient finding was glial cell proliferation in layer 4 and deep parts of layer 3 of the cerebral cortex. Glial cell proliferation was most marked in animals that exhibited deterioration of steady state schedule performance.
Hymowitz
N
N
Department of Psychiatry, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
Ploshnick
A
A
Laemle
L
L
Brezenoff
H
H
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D004334:Drug Administration Schedule; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D012999:Soman / Q000008:administration & dosage / Q000633:toxicity*
D012999:Soman