title: Further characterization, isolation and identification of the epithelial cell-surface antigen defined by monoclonal antibody AUA1.
abstract: The human epithelial antigen recognized monoclonal antibody (MAb) AUA1 has been characterized as a cell-surface glycoprotein. It has been isolated from human colonic mucosa by AUA1 affinity separation. N-terminal peptide sequence of this purified material has revealed a 17 amino acid sequence which identifies it with one of a group of similar epithelial/tumor-associated glycoproteins defined by a variety of MAbs. Using the polymerase chain reaction to map the gene encoding this antigen, our previous AUA1 antigen assignment to chromosome 2 has been confirmed.
authors.affiliation: Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Durbin
authors.forename: N
authors.initials: N
authors.lastname: Rodrigues
authors.forename: W F
authors.initials: WF
authors.lastname: Bodmer
mesh_terms: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics; D001483:Base Sequence; D003106:Colon / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000235:genetics; D008969:Molecular Sequence Data; D008970:Molecular Weight; D018396:Mucin-1
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D008562:Membrane Glycoproteins; D018396:Mucin-1