Blood kinetics of sulfamonomethoxine and oxytetracycline following intrauterine spray injection in dairy cows.
Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst oxytetracycline quantities were detected by a microbiological method. The sulphonamide had a peak 1.17 h after the administration, the tetracycline reached its highest concentration after 8 h. The bioavailability of both drugs was low and detectable drug amounts were no longer recovered after 24 h.
Girardi
C
C
Dipartimento di Patologia Animale, Università di Torino, Italia.
Re
G
G
Farca
A M
AM
Dacasto
M
M
Ferrero
E
E
Eandi
M
M
D000818:Animals; D001682:Biological Availability; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007267:Injections; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D013422:Sulfamonomethoxine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013424:Sulfanilamides / Q000493:pharmacokinetics*; D014599:Uterus
D013424:Sulfanilamides; D013422:Sulfamonomethoxine; D010118:Oxytetracycline