title: Stepwise oligogenic segregation and linkage analysis illustrated with dopamine-beta-hydroxylase activity.
abstract: A stepwise oligogenic method is developed that can be used to adjust the phenotype of a quantitative trait for the effects of a previously identified single-locus component. This method assumes that a single-locus component can be adequately identified through the use of segregation and/or linkage analysis under a 1-locus model and that the variation due to that locus can be removed from the phenotype leaving a residual that can be parameterized in terms of an additional single-locus component. Segregation and/or linkage analysis can then be used in an attempt to identify an additional single-locus component in the residual phenotype. This stepwise process can be repeated until no further single-locus effects are identified. The method is illustrated using family data on the specific activity of dopamine-beta-hydroxylase (DBH), which a number of studies have suggested may be due either to the combined effects of single-locus and multifactorial components or to the combined effects of 2 loci.
authors.affiliation: Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112-1393.
authors.forename: A F
authors.initials: AF
authors.lastname: Wilson
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: T A
authors.initials: TA
authors.lastname: Sellers
authors.forename: J E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: J M
authors.initials: JM
authors.lastname: Gersting
authors.forename: D K
authors.initials: DK
authors.lastname: Deen
authors.forename: A J
authors.initials: AJ
authors.lastname: Sorant
authors.forename: L D
authors.initials: LD
authors.lastname: Tran
authors.forename: C I
authors.initials: CI
authors.lastname: Amos
authors.forename: R M
authors.initials: RM
authors.lastname: Siervogel
mesh_terms: D003434:Crossing Over, Genetic; D004299:Dopamine beta-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D011995:Recombination, Genetic
chemical_list: D004299:Dopamine beta-Hydroxylase