Effects of sodium iodate on experimental subretinal neovascularization in the primate.
We investigated the role of the retinal pigment epithelium (RPE) in the development of subretinal neovascularization (SRN) induced by bilateral laser photocoagulation of the retinas in monkeys. RPE function was affected by a unilateral carotid injection of sodium iodate, a selective RPE toxin, before laser photocoagulation. This caused severe RPE damage in the ipsilateral eye, but did not affect the contralateral eye. After laser photocoagulation no SRN was demonstrable clinically or histopathologically in the ipsilateral eye; in contrast, active SRN showing extensive fluorescein leakage was found in the contralateral eye. These results suggest that RPE may play a role in the development of laser-induced SRN.
Nishimura
T
T
Department of Ophthalmology, University of Southern California, Los Angeles.
Zhu
Z R
ZR
Ryan
S J
SJ
D000818:Animals; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D007452:Iodates; D008028:Light Coagulation; D008252:Macaca fascicularis; D008264:Macrophages; D010857:Pigment Epithelium of Eye / Q000503:physiopathology* / Q000648:ultrastructure; D015861:Retinal Neovascularization / Q000209:etiology* / Q000473:pathology
D007452:Iodates; C032285:sodium iodate