title: Decidualization in the post-partum uterus of the mouse.
abstract: Unilaterally ovariectomized mice were allowed to complete one pregnancy before the second ovary was removed and sensitivity to decidualization was induced by hormone administration. The virgin uterine horn and the post-partum horn were stimulated to decidualize by the intraluminal injection of arachis oil. A greater decidual response was found in post-partum horns than in virgin horns. The foci of decidual induction in post-partum horns were regularly spaced reflecting the regular spacing of used and unused areas of the uterus. A focus of decidual induction occurred in 68% of the recently used uterine areas observed, i.e. areas associated with post-partum nodules. When compared with foci of decidualization in adjacent unused areas of the uterus, none of the decidualized used zones showed more decidual tissue, about half showed less decidual tissue and half showed the same amount of decidual tissue. The remaining 32% of used zones were not associated with foci of decidual induction. The results indicate that decidualization can be induced in recently used zones of the uterus using a non-traumatic method of induction, but that used zones are associated with less decidual tissue than unused zones of the post-partum uterus.
authors.affiliation: Department of Zoology, University of Oxford, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Brandon
mesh_terms: D000818:Animals; D010367:Arachis; D003656:Decidua / Q000254:growth & development*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D010052:Ovariectomy; D000074241:Peanut Oil; D010938:Plant Oils / Q000494:pharmacology; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy; D014599:Uterus / Q000033:anatomy & histology
chemical_list: D000074241:Peanut Oil; D010938:Plant Oils