Nucleotide sequence and structure analysis of cDNAs encoding short-chain neurotoxins from venom glands of a sea snake (Aipysurus laevis).
Two cDNAs from the sea snake Aipysurus laevis have been cloned and sequenced. They encode isoforms of short chain neurotoxins. One of them is toxin b, previously isolated from the venom of Aipysurus laevis and sequenced by Maeda and Tamiya (Biochem. J. 153, 79, 1976), whereas the other corresponds to an isoform which was not hitherto described. The two toxin sequences differ from each other by three amino-acid residues. Both cDNA structures were comparable with that previously determined in our laboratory for erabutoxin a from Laticauda semifasciata.
Ducancel
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F
Département de Biologie du Centre d'Etudes, Nucléaires de Saclay, Gif sur Yvette, France.
Guignery-Frelat
G
G
Boulain
J C
JC
Ménez
A
A
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D005088:Exocrine Glands / Q000378:metabolism*; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000032:analysis* / Q000235:genetics; D012911:Snakes / Q000378:metabolism*
D009498:Neurotoxins; D004247:DNA