Pulmonary carcinogenesis in rats given implants of shale oil in beeswax pellets.
Pellets of crude shale oil, neutral, basic, or polynuclear aromatic fractions of shale oil, or crude petroleum were implanted in the lungs of rats through a thoracotomy. The pellets had a beeswax-tricaprylin vehicle that allowed the slow release of material into the surrounding parenchyma. A dose-related incidence of lung cancer was observed with each of the materials studies. A greater risk for lung cancer was not demonstrated for crude shale oil compared to crude petroleum.
Dagle
G E
GE
Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, Washington 99352.
Smith
L G
LG
McDonald
K E
KE
McShane
J F
JF
Stevens
D L
DL
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004343:Drug Implants; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D010578:Petroleum / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
D004343:Drug Implants; D010578:Petroleum