title: [Use of automatic blood analyzer, Hemalog D, in cancer patients during radiotherapy and chemotherapy].
abstract: The Hemalog D automatic cytochemical analyser was used to assess changes in the levels of neutrophil peroxidase and monocyte non-specific esterase in 194 cancer patients undergoing radiation and chemotherapy. Radiotherapy in the dose of 30-48 Gy did not affect functional activity of blood leukocytes. Combination chemotherapy induced moderate or severe leukopenia in 72.7% of cases. A decrease in the enzymatic activity of neutrophils and monocytes was observed in patients with normal and slightly decreased leukocyte counts. In patients with severe leukopenia, elevated levels of peroxidase and non-specific esterase in leukocytes were found.
authors.forename: G N
authors.initials: GN
authors.lastname: Zubrikhina
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Manakhova
authors.forename: E A
authors.initials: EA
authors.lastname: Solov'eva
authors.forename: N B
authors.initials: NB
authors.lastname: Lebedeva
authors.forename: Z Kh
authors.initials: ZKh
authors.lastname: Khaĭretdinova
authors.forename: V K
authors.initials: VK
authors.lastname: Kachalov
authors.forename: A I
authors.initials: AI
authors.lastname: Lebedev
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D004950:Esterases / Q000097:blood; D006405:Hematology / Q000295:instrumentation*; D006651:Histocytochemistry / Q000295:instrumentation; D006801:Humans; D007958:Leukocyte Count / Q000295:instrumentation*; D007962:Leukocytes / Q000201:enzymology / Q000528:radiation effects; D007963:Leukocytes, Mononuclear / Q000201:enzymology; D007970:Leukopenia / Q000139:chemically induced / Q000175:diagnosis; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy; D009504:Neutrophils / Q000201:enzymology; D010544:Peroxidases / Q000097:blood
chemical_list: D010544:Peroxidases; D004950:Esterases
vernacular_title: Primenenie avtomaticheskogo analizatora krovi "gemalog D" u onkologicheskikh bol'nykh v protsesse luchevoĭ i khimioterapii.