title: Antibiotics from basidiomycetes. XXXII. Strobilurin E: a new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotic from Crepidotus fulvotomentosus Peck.
abstract: Strobilurin E is a novel antibiotic of the (E)-beta-methoxyacrylate (MOA) class produced by mycelial cultures of the agaric Crepidotus fulvotomentosus. In addition to an inhibition of fungal respiration, a feature of all MOA-antibiotics, the compound exhibits very high cytostatic activities which are accompanied by reversible morphological alterations of the cells.
authors.affiliation: Lehrbereich Biotechnologie der Universität Kaiserslautern, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: B
authors.initials: B
authors.lastname: Steffan
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000179:Acrylates / Q000302:isolation & purification / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D005231:Fatty Acids, Unsaturated; D005285:Fermentation; D005658:Fungi / Q000187:drug effects / Q000378:metabolism; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008689:Methacrylates; D000073739:Strobilurins
chemical_list: D000179:Acrylates; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; D000255:Adenosine Triphosphate; C063436:strobilurin E