title: Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study.
abstract: Reticulate pigmentation with or without skin atrophy, depigmentation and telangiectasia is frequently encountered on the neck of severe cases of adult type atopic dermatitis. These skin changes were graded clinically into 3 stages. Based on histological features, hyperplasia of the sebaceous gland, dilated tortuous capillaries, and mild degeneration of elastic fibers were noted in stage I lesions. Lesions of both stages II and III contained increased melanin in the basal cell layer with incontinence of pigment, remarkable destruction and degeneration of elastic fibers, proliferated and dilated capillaries, and deposition of mucinous substances. The numbers of mast cells in papillary dermis were significantly increased in late stage I and stage II lesions. Poikiloderma-like lesions on the neck could be attributable to chronic inflammation and delay of wound healing process, possibly caused by long-standing topical corticosteroid therapy.
authors.affiliation: Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mukai
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: K
authors.initials: K
authors.lastname: Kamimura
authors.forename: I
authors.initials: I
authors.lastname: Katayama
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D002452:Cell Count; D003876:Dermatitis, Atopic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000473:pathology; D009333:Neck; D010859:Pigmentation Disorders / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000473:pathology*