Direct cardiovascular actions of two metabolites of linoleic acid.
Two newly discovered oxidation products of linoleic acid (i.e., 9,10-epoxy-12-octadecenoate termed Leukotoxin A, and 12,13-epoxy-9-octadecenoate termed Leukotoxin B) are produced by neutrophils in a variety of species. These substances appear to combat bacterial infection although they also have detrimental effects on normal organ function. Administration of Leukotoxin A or B to isolated cat papillary muscles decreased developed force, an index of myocardial contractility, in a concentration-dependent manner. Leukotoxin B was more active in decreasing the developed force than Leukotoxin A at high concentrations. Leukotoxin A or B, when added to isolated perfused cat carotid arteries, produced a significant vasoconstriction which in vivo would result in an increased vascular resistance. Thus, leukotoxins exert significant direct effects on the cardiovascular system in cats. Leukotoxins A and B are both cardiodepressant and vasoactive independent of release of other blood borne mediators.
Siegfried
M R
MR
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Aoki
N
N
Lefer
A M
AM
Elisseou
E M
EM
Zipkin
R E
RE
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects; D002415:Cats; D046508:Culture Techniques; D008041:Linoleic Acids / Q000633:toxicity*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D014118:Toxins, Biological / Q000633:toxicity*; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D008041:Linoleic Acids; D014118:Toxins, Biological; C055944:12,13-epoxy-9(2),11-octadecadienoic acid; C051208:9,10-epoxy-12-octadecenoic acid