Use of DBA/2N mice in models of systemic candidiasis and pulmonary and systemic aspergillosis.
Mouse models of systemic candidiasis and pulmonary and systemic aspergillosis were established by using DBA/2N mice, which are known to be deficient in the C5 component of complement. In experiments comparing lethality in the respective models in DBA/2N versus outbred CFW mice, results showed that the 50% lethal dose values for the DBA/2N mice were 10- to 1,000-fold lower than those for the outbred mice, depending on the experiment. Additionally, onset of death was somewhat delayed for the DBA/2N mice. In the case of the pulmonary aspergillosis model, administration of cortisone acetate was necessary to ensure lethality after intranasal infection, but only a single dose was necessary.
Hector
R F
RF
Cutter Biological, Berkeley, California 94710.
Yee
E
E
Collins
M S
MS
D000818:Animals; D001228:Aspergillosis / Q000503:physiopathology*; D002177:Candidiasis / Q000503:physiopathology*; D003182:Complement C5 / Q000172:deficiency; D004195:Disease Models, Animal; D008171:Lung Diseases / Q000382:microbiology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA / Q000382:microbiology*; D013997:Time Factors
D003182:Complement C5