SF2487, a new polyether antibiotic produced by Actinomadura.
A new antibiotic SF2487 has been isolated from the culture broth of Actinomadura sp. SF2487. The structure of antibiotic SF2487 was determined by spectroscopic analyses of the sodium salt and X-ray diffraction analysis of the silver salt. The antibiotic represents a new member of polyether group antibiotics known as the acyltetronic acid type 4. The antibiotic is weakly active against Gram-positive bacteria and exhibits antiviral activity against influenza virus in vitro.
Hatsu
M
M
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Sasaki
T
T
Miyadoh
S
S
Watabe
H
H
Takeuchi
Y
Y
Kodama
Y
Y
Orikasa
Y
Y
Kajii
K
K
Shomura
T
T
Yamamoto
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005285:Fermentation; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009618:Nocardiaceae / Q000145:classification / Q000378:metabolism*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D005663:Furans; C063728:SF 2487