title: Lytic cocktail in children. Rectal versus intramuscular administration.
abstract: The efficacy of the lytic cocktail (1 ml contains pethidine 28 mg, promethazine 7 mg, chlorpromazine 7 mg) administered intramuscularly or rectally as premedication was studied in 51 children aged 1-12 years who had minor elective otological surgery. One group received 0.05 ml/kg intramuscularly (maximum dose 2.0 ml) and the other 0.07 ml/kg per rectum (maximum dose 2.8 ml). Most were satisfactorily sedated before operation, but after operation the rectally premedicated children were less sedated, which was in agreement with lower plasma pethidine concentrations in this group. The rectal dose should be increased if prolonged postoperative sedation is desireable.
authors.affiliation: Department of Anaesthesia, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Laub
authors.forename: P
authors.initials: P
authors.lastname: Sjøgren
authors.forename: R
authors.initials: R
authors.lastname: Holm-Knudsen
authors.forename: H
authors.initials: H
authors.lastname: Flachs
authors.forename: E
authors.initials: E
authors.lastname: Christiansen
mesh_terms: D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D008614:Meperidine / Q000008:administration & dosage* / Q000097:blood; D011229:Preanesthetic Medication; D011398:Promethazine / Q000008:administration & dosage*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D008614:Meperidine; D011398:Promethazine; D002746:Chlorpromazine