In-111-labeled monoclonal antibody immunoscintigraphy in colorectal carcinoma: safety, sensitivity, and preliminary clinical results.
A phase I/II prospective clinical trial was performed with indium-111-labeled monoclonal antibody (MoAb) conjugate B72.3-glycyl-tyrosyl N-epsilon-diethylenetriaminepentaacetic acid (CYT-103) in 28 preoperative patients with biopsy-proved or suspected colorectal carcinomas. Immunoscintigraphy was performed 2-7 days after infusion of 4.1 mCi (152 MBq) of In-111 labeled to CYT-103 at doses of 0.5, 1.0, 2.0, and 20.0 mg. Surgical and histologic confirmation was available in all cases. Use of In-111 CYT-103 made possible detection of 75% of colorectal carcinomas at doses of 1.0 mg and higher, compared with only 20% detection at the 0.5-mg MoAb dose. Immunohistochemical staining for tumor-associated glycoprotein (TAG)-72 in resected carcinoma tissues demonstrated a positive correlation between MoAb imaging and the percentage of cells that expressed TAG-72. One patient suffered an adverse reaction after MoAb infusion. Human antimouse response to CYT-103 developed in 16% of patients.
Abdel-Nabi
H
H
Department of Nuclear Medicine, Veterans Administration Medical Center, School of Medicine and Biomedical Sciences, SUNY, Buffalo 14214.
Doerr
R J
RJ
Chan
H W
HW
Balu
D
D
Schmelter
R F
RF
Maguire
R T
RT
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000276:immunology; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000032:analysis; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D004341:Drug Evaluation; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007205:Indium Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000627:therapeutic use; D004369:Pentetic Acid / Q000627:therapeutic use / Q000031:analogs & derivatives; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D015899:Tomography, Emission-Computed, Single-Photon
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C063430:Indium 111In-satumomab pendetide; D007205:Indium Radioisotopes; D009842:Oligopeptides; C047052:tumor-associated antigen 72; D004369:Pentetic Acid