Exposure to dioxins as a risk factor for soft tissue sarcoma: a population-based case-control study.
In a case-control study including 237 cases with soft tissue sarcoma and 237 controls, previous jobs and exposures to different agents, including pesticides, were assessed. Exposure to phenoxyacetic acids or chlorophenols gave a statistically significant increased rate ratio (RR) of 1.80 [95% confidence interval (CI) = 1.02-3.18] for soft tissue sarcoma. Exposure to phenoxyacetic acids of all types gave a nonsignificantly increased RR of 1.34 (95% CI = 0.70-2.56). During the 1950s, exposure to 2,4,5-trichlorophenoxyacetic acid gave a threefold significantly increased risk. High-grade exposure to chlorophenols, which are also contaminated by dioxins, gave an RR of 5.25 (95% CI = 1.69-16.34). The increased risk was thus attributed to dioxin-contaminated phenoxyacetic acids or chlorophenols that gave an RR of 2.43 (95% CI = 1.30-4.54).
Eriksson
M
M
Department of Oncology, University Hospital, Umeå, Sweden.
Hardell
L
L
Adami
H O
HO
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002733:Chlorophenols / Q000633:toxicity; D004147:Dioxins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D010642:Phenoxyacetates / Q000633:toxicity; D012307:Risk Factors; D012509:Sarcoma / Q000139:chemically induced*; D011795:Surveys and Questionnaires; D013548:Sweden
D002733:Chlorophenols; D004147:Dioxins; D010642:Phenoxyacetates