Tissue accumulation of lipoprotein associated toxaphene in normo- and hypolipidemic mice.
Normo- and hypolipidemic mice were given a single i.v. injection of 14C-toxaphene associated with low density lipoprotein (LDL), high density lipoprotein (HDL) or dimethyl sulfoxide (DMSO). The tissue distribution of radioactivity was studied 20 min and 4 h after the application. In the normolipidemic mice at 20 min postinjection there was high uptake of the 14C-toxaphene preparations in the liver and adrenals followed after 4 h by a redistribution to the adipose tissues. In the hypolipidemic mice, proportionally less label accumulated initially in the liver and adrenals while more radioactivity was seen in the kidneys and heart. The radioactivity then redistributed to the liver with a very small uptake in the adipose tissue compared to the normolipidemic mice after 4 h. The results indicate that changes in the lipid pattern, e.g. hypolipidemic conditions, may influence the tissue distribution of lipophilic xenobiotics.
Mohammed
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A
Toxicology Laboratory, National Food Administration, Uppsala, Sweden.
Eklund
A
A
Ostlund-Lindqvist
A M
AM
Slanina
P
P
D000818:Animals; D002250:Carbon Radioisotopes; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D005260:Female; D007009:Hypolipoproteinemias / Q000097:blood*; D007275:Injections, Intravenous; D007306:Insecticides / Q000493:pharmacokinetics*; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D051379:Mice; D013997:Time Factors; D014018:Tissue Distribution; D014112:Toxaphene / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D007306:Insecticides; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014112:Toxaphene; D004121:Dimethyl Sulfoxide