title: Cervical intraepithelial neoplasia. The role of age at first coitus in its etiology.
abstract: A case-control study was done on 115 women attending a colposcopy clinic. All the patients had definitive histologic confirmation of cervical intraepithelial neoplasia (CIN). A specially designed questionnaire sought information about their age, age at first coitus, gravidity, ethnic origin, religion and social class. Cases and controls were closely matched for age and the last three parameters mentioned above. There was no statistical difference between nulliparas and multiparas in the incidence of CIN. The time interval between age at first coitus and the diagnosis of CIN varied widely, with 47 years the maximum. Statistically significant differences existed between the age at first coitus for cases and controls under and over age 18. The estimated relative risk was 3.64-fold higher in those under 18 than in those 18 or over at first coitus.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Liverpool Hospital, England.
authors.forename: A A
authors.initials: AA
authors.lastname: Edebiri
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002278:Carcinoma in Situ / Q000209:etiology*; D003075:Coitus; D005260:Female; D006801:Humans; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000209:etiology*