title: Androgen receptors--a method to measure functional behaviour in human prostatic cancer.
abstract: Androgen receptors were measured in soluble and nuclear fractions of tissues obtained from 25 patients. A method using mibolerone, a synthetic androgen, as a ligand is described. This method, which includes the presence of excess ORG 2058 to eliminate interaction with progesterone receptors, gives a reliable determination of androgen receptor content and has been used to predict response to hormonal treatment. However, the results suggest that the presence of functional receptor is not, in itself, a sufficient index of hormonal dependence of the tumour.
authors.affiliation: Western Infirmary Department of Urology, Glasgow University, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Kirkali
authors.forename: L E
authors.initials: LE
authors.lastname: Moffat
authors.forename: R
authors.initials: R
authors.lastname: Leake
authors.forename: S
authors.initials: S
authors.lastname: Cowan
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: D
authors.initials: D
authors.lastname: Kirk
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004054:Diethylstilbestrol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D011944:Receptors, Androgen / Q000032:analysis*
chemical_list: D011944:Receptors, Androgen; D004054:Diethylstilbestrol