Triple-quantum-coherence-filtered imaging of sodium ions in vivo at 4.7 tesla.
The tissue distribution of sodium ions which generate triple-quantum coherence (TQC) in vivo is determined from images. A technique for filtering conventional sodium images, so that signal is obtained only from sodium ions which have a correlation time appropriate for producing TQC, is described. The utility of TQC-filtered sodium images is demonstrated in a study of tumors implanted in a nude rat model, where the intensity of the TQC signal from sodium ions in the growing margin of the tumor is observed to be 200-250% greater than that from surrounding tissue.
Griffey
R H
RH
Center for Non-invasive Diagnosis, University of New Mexico School of Medicine, Albuquerque 87131.
Griffey
B V
BV
Matwiyoff
N A
NA
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005910:Glioma / Q000175:diagnosis* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051381:Rats; D011923:Rats, Nude; D012964:Sodium / Q000502:physiology*
D012964:Sodium