title: Effect of increasing amounts of dietary fish oil on brain and liver fatty composition.
abstract: Increasing dietary fish oil in rat had the following effect on brain lipids: Arachidonic acid regularly decreased; eicosapentanenoic acid, normally nearly undetectable, was present; 22:5(n - 3), dramatically increased but remained below 1% of total fatty acids; cervonic acid was increased by 30% at high fish oil concentration. Saturated and monounsaturated fatty acids were not affected regardless of chain-length. In contrast, in the liver, nearly all fatty acids (saturated, monounsaturated and polyunsaturated) were affected by high dietary content of fish oil, but liver function was normal: serum vitamin A and E, glutathione peroxidase, alkaline phosphatase, transaminases were not affected. Serum total cholesterol, unesterified cholesterol and phosphatidylcholine were slightly affected. In contrast, triacylglycerols were dramatically reduced in proportion to the fish oil content of the diet.
authors.affiliation: INSERM Unité 26, Hôpital Fernand Widal, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
authors.forename: M
authors.initials: M
authors.lastname: Bonneil
authors.forename: O
authors.initials: O
authors.lastname: Dumont
authors.forename: M
authors.initials: M
authors.lastname: Piciotti
authors.forename: R
authors.initials: R
authors.lastname: Calaf
authors.forename: H
authors.initials: H
authors.lastname: Portugal
authors.forename: G
authors.initials: G
authors.lastname: Nalbone
authors.forename: H
authors.initials: H
authors.lastname: Lafont
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005395:Fish Oils / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils