title: Medical dissolution of feline struvite urocystoliths.
abstract: The efficacy of a diet designed to facilitate dissolution of feline magnesium ammonium phosphate (struvite) uroliths was evaluated in 30 cases of urolithiasis, sterile struvite uroliths dissolved in a mean of 36 days after initiation of dietary treatment. In 5 cases of urolithiasis, struvite urocystoliths associated with urease-negative bacterial urinary tract infection dissolved in a mean of 23 days after initiation of dietary and antimicrobial treatment. In 3 cases of urolithiasis, struvite urocystoliths associated with urease-positive staphylococcal urinary tract infection dissolved in a mean of 79 days after initiation of dietary and antimicrobial treatment. Dissolution of uroliths in cats fed the treatment diet was associated with concomitant remission of dysuria, hematuria, and pyuria, and reduction in urine pH and struvite crystalluria. In one case, a urocystolith composed of 100% ammonium urate, and in another case, a urolith composed of 60% calcium phosphate, 20% calcium oxalate, and 20% magnesium ammonium phosphate did not dissolve.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
authors.forename: C A
authors.initials: CA
authors.lastname: Osborne
authors.forename: J P
authors.initials: JP
authors.lastname: Lulich
authors.forename: J M
authors.initials: JM
authors.lastname: Kruger
authors.forename: D J
authors.initials: DJ
authors.lastname: Polzin
authors.forename: G R
authors.initials: GR
authors.lastname: Johnston
authors.forename: R A
authors.initials: RA
authors.lastname: Kroll
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000818:Animals; D002371:Cat Diseases / Q000000981:diagnostic imaging / Q000178:diet therapy*; D002415:Cats; D002969:Clavulanic Acids / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000032:analysis / Q000652:urine; D017616:Magnesium Compounds; D008297:Male; D010710:Phosphates / Q000032:analysis / Q000652:urine; D011859:Radiography; D012008:Recurrence; D013046:Specific Gravity; D000069877:Struvite; D013997:Time Factors; D014545:Urinary Calculi / Q000032:analysis / Q000000981:diagnostic imaging / Q000178:diet therapy / Q000652:urine / Q000662:veterinary*; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary
chemical_list: D002969:Clavulanic Acids; D017616:Magnesium Compounds; D010710:Phosphates; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D000069877:Struvite; D008274:Magnesium