title: Two patterns of firing in human neocortical neurons.
abstract: Intracellular recordings were made in slices of human neocortex removed for surgical treatment of epilepsy. In response to prolonged suprathreshold current injection, regular spiking neurons (67.5% of sample) responded by repetitive firing throughout the stimulus from all membrane potentials. Bursting neurons (32.5% of sample) responded with a burst of 2-3 spikes which rode upon a voltage-dependent slow depolarization. Bursting behavior was only observed from membrane potentials more negative than -65 mV.
authors.affiliation: Department of Anatomy, University of Tennessee, Memphis 38163.
authors.forename: R C
authors.initials: RC
authors.lastname: Foehring
authors.forename: A R
authors.initials: AR
authors.lastname: Wyler
mesh_terms: D002540:Cerebral Cortex / Q000502:physiology*; D005071:Evoked Potentials; D006801:Humans; D008564:Membrane Potentials