title: Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
abstract: Normal and hypertrophied rat detrusor were investigated in vitro with regard to effects of the K(+)-channel openers pinacidil and cromakalim. Both drugs abolished spontaneous contractile activity and induced a relaxation of normal and hypertrophied detrusor preparations. In both types of preparation, contractions elicited by K+, carbachol or electrical field stimulation were depressed in the presence of the K(+)-channel openers. Responses induced by K+ or electrical stimulation were more reduced in the hypertrophied than in the normal detrusor. Both K(+)-channel openers increased the efflux of 86Rb+ in a concentration-dependent way and this increase was similar in normal and hypertrophied detrusor. If applicable to man, this data suggest that K(+)-channel openers may be effective in the treatment of bladder instability secondary to outflow obstruction.
authors.affiliation: Department of Clinical Pharmacology, University of Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Malmgren
authors.forename: K E
authors.initials: KE
authors.lastname: Andersson
authors.forename: P O
authors.initials: PO
authors.lastname: Andersson
authors.forename: M
authors.initials: M
authors.lastname: Fovaeus
authors.forename: C
authors.initials: C
authors.lastname: Sjögren
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D019806:Cromakalim; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006984:Hypertrophy; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D020110:Pinacidil; D011188:Potassium / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D001578:Benzopyrans; D006146:Guanidines; D011758:Pyrroles; D014665:Vasodilator Agents; D019806:Cromakalim; D020110:Pinacidil; D002217:Carbachol; D011188:Potassium