Effect of intraduodenal bile and Na- taurodeoxycholate on exocrine pancreatic secretion and on plasma levels of secretin, pancreatic polypeptide, and gastrin in man.
The effect of intraduodenally administered cattle bile (CB) and Na-taurodeoxycholate (TDC) on basal pancreatic secretion and plasma levels of secretin, pancreatic polypeptide (PP), and gastrin were investigated on two separate days in 10 fasting volunteers. Doses of 2-6 g CB and 200-600 mg TDC were given intraduodenally at 65-min intervals. Volume, bicarbonate, lipase, trypsin, amylase, and bilirubin were measured in 10-min fractions of duodenal juice, and GI peptides determined by radioimmunoassay. CB and TDC enhanced significantly and dose-dependently volume, bicarbonate and enzyme secretion, and plasma secretin and PP levels. In contrast, plasma gastrin showed only a marginal increase. We conclude that the hydrokinetic effect of intraduodenal CB and TDC is at least partially mediated by secretin. Gastrin could be ruled out as a mediator of the ecbolic effect, whereas other GI peptides, primarily CCK, and/or neural mechanisms must be considered possible mediators. Both pathways may also play a role in the PP release observed.
Riepl
R L
RL
Medical Clinic 'Innenstadt', University of Munich, FRG.
Lehnert
P
P
Scharl
A
A
Hempen
I
I
Fiedler
F
F
Teufel
J
J
Burhol
P G
PG
D000328:Adult; D000818:Animals; D001646:Bile; D002417:Cattle; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D005755:Gastrins / Q000097:blood*; D006801:Humans; D010179:Pancreas / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000097:blood*; D012633:Secretin / Q000097:blood* / Q000502:physiology; D013657:Taurodeoxycholic Acid / Q000494:pharmacology*
D005755:Gastrins; D003840:Deoxycholic Acid; D012633:Secretin; D013657:Taurodeoxycholic Acid; D010191:Pancreatic Polypeptide