[Correlation between gastric microcirculation and mucosal injury after surgical therapy of esophageal varices].
The correlation between gastric microcirculation and mucosal injury was studied in patients who underwent surgery for esophageal varices. Both mucosal and submucosal blood flow at the lower esophagus, gastric body and antrum was measured using hydrogen gas clearance method through endoscopy in 55 patients including 33 cirrhotics, 10 idiopathic portal hypertensive patients and 12 controls. In 20 cases with esophageal varices, 10 patients were treated with transabdominal esophageal transection (transection group) and 10 with left gastric vena caval shunt (shunt group). The patients with portal hypertension, showed a reduced blood flow in gastric mucosa but increased flow in the submucosa, as compared with the controls. When comparing the postoperative changes in gastric mucosal flow between the two groups, the transection group showed a reduction of mucosal flow by approximately 30% during surgery, and 20% for 4 weeks after operation. In shunt group, the mucosal flow was well preserved with reduction rate less than 10%. Postoperative mucosal injury was endoscopically and histologically found in almost all patients who showed a reduction rate of more than 20%. This study suggests that active protection against possible gastric mucosal lesion should be kept in mind in the setting of surgical therapy for esophageal varices.
Mitarai
Y
Y
Department of Surgery 1, Medical College of Oita, Japan.
Kobayashi
M
M
D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D008103:Liver Cirrhosis / Q000150:complications; D008111:Liver Function Tests; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011184:Postoperative Period; D013270:Stomach / Q000098:blood supply*