title: Microbial metabolism studies of the antimalarial drug arteether.
abstract: Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized by a number of microorganisms. Large-scale fermentation with Aspergillus niger (ATCC 10549) and Nocardia corallina (ATCC 19070) have resulted in the isolation of four microbial metabolites which have been characterized using two-dimensional nuclear magnetic resonance (2D-NMR) techniques. These metabolites have been identified as "AEM1" (2), 3 alpha-hydroxydeoxyarteether (3), 3 alpha-hydroxydeoxydihydroartemisinin (4), and deoxydihydroartemisinin (5).
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: H N
authors.initials: HN
authors.lastname: ElSohly
authors.forename: C D
authors.initials: CD
authors.lastname: Hufford
mesh_terms: D000962:Antimalarials / Q000378:metabolism*; D037621:Artemisinins; D001234:Aspergillus niger / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003470:Culture Media; D005658:Fungi / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D003470:Culture Media; D012717:Sesquiterpenes; C055141:artemotil