AcSDKP, an inhibitor of CFU-S proliferation, is synthesized in mice under steady-state conditions and secreted by bone marrow in long-term culture.
The peptide AcSDKP, isolated from fetal calf bone marrow, is able to prevent DNA synthesis in mouse CFU-S in vivo and in vitro. The molecule is demonstrated here to be constitutively produced in mice and synthesized by bone marrow cells in long term culture.
Wdzieczak-Bakala
J
J
INSERM U.250, Gustave-Roussy Institute, Villejuif, France.
Fache
M P
MP
Lenfant
M
M
Frindel
E
E
Sainteny
F
F
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides / Q000096:biosynthesis* / Q000378:metabolism
D009842:Oligopeptides; C058504:goralatide