title: Inhibition of interleukin 1 (IL-1)-elicited leukocytosis and LPS-induced fever by soluble immune response suppressor (SIRS).
abstract: IL-1-induced leukocytosis was inhibited or blocked in a dose-dependent manner by SIRS, an antigen-nonspecific suppressive lymphokine, when administered intravenously or per os to CBA mice. Timing experiments showed that SIRS effectively inhibited the leukocytosis when administered within 30 minutes of the IL-1. An antipyrogenic activity of SIRS was observed in rabbits injected intravenously with LPS. SIRS, given intravenously in one or two doses, markedly reduced LPS-induced fever. SIRS (2000 units) was a more effective antipyretic agent than aspirin (3 mg/kg body weight, intramuscularly). The results suggest that SIRS may be a potential drug for use in IL-1-mediated disorders.
authors.affiliation: Department of Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Zimecki
authors.forename: H W
authors.initials: HW
authors.lastname: Schnaper
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
authors.forename: D R
authors.initials: DR
authors.lastname: Webb
authors.forename: C W
authors.initials: CW
authors.lastname: Pierce
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007958:Leukocyte Count; D007964:Leukocytosis / Q000139:chemically induced*; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013491:Suppressor Factors, Immunologic / Q000494:pharmacology*
chemical_list: D007375:Interleukin-1; D011135:Polysaccharides, Bacterial; D013491:Suppressor Factors, Immunologic; C013256:soluble immune response suppressor