Bilateral choroidal neonatal neuroblastoma.
We treated a bilateral, well-differentiated neuroblastoma of the choroid in a patient who had congenital abdominal neuroblastoma. Although orbital metastasis of neuroblastoma is common, intraocular metastasis is not. In our patient, there was no amplification of the N-myc oncogene in the tumor of either eye. This is consistent with early-stage primary neuroblastoma. Histologically, the tumors were identical in each eye and well differentiated with Homer Wright rosettes; most neuroblastoma metastases have few rosettes and are composed of more undifferentiated, anaplastic cells. We believe that our patient had bilateral primary tumors and not metastatic tumors.
Cibis
G W
GW
Children's Mercy Hospital, Section of Ophthalmology, Kansas City, Missouri.
Freeman
A I
AI
Pang
V
V
Roloson
G J
GJ
Case
W F
WF
Ost
M
M
Huntrakoon
M
M
Rothberg
P G
PG
D002830:Choroid Neoplasms / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000151:congenital*; D009447:Neuroblastoma / Q000151:congenital* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed