[The influence of the Soviet antimalarial preparation dabequin on the hemostatic system and on the anticoagulant effect of heparin].
In experiments on rabbits and experiments in vitro dabechin was shown to decrease the blood coagulation status and to change the anticoagulant effect of heparin. The latter depends on the route and duration of administration of the antimalarial drug. Injections of heparin in the period of the maximal blood content of dabechin decrease the specific action of the anticoagulant. A prolonged oral administration of dabechin enhances the anticoagulant effect of heparin. During in vitro experiments the ability of dabechin to neutralize heparin with a simultaneous decrease of its specific action was shown.
Pomortseva
I V
IV
Ovchinnikova
L K
LK
Shcheglova
N V
NV
D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants; D000962:Antimalarials / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D013916:Thrombelastography; D013997:Time Factors
D000634:Aminoquinolines; D000925:Anticoagulants; D000962:Antimalarials; C015773:dabequin; D006493:Heparin
Issledovanie vliianiia otechestvennogo protivomaliariĭnoĭ preparaty dabekhina na sistemu gemostaza i antikoaguliantnyĭ éffekt geparina.