title: Long-term intraventricular infusion of morphine for intractable pain in cancer of the head and neck.
abstract: The authors' experience with seven patients with intractable pain that was treated by continuous intraventricular infusion of morphine through an implanted Infusaid pump is reported. The pain was caused by head and neck cancer in six patients and was associated with postpolio syndrome in one. The average follow-up was 7 months. Pain was effectively managed through intraventricular administration of a combination of morphine and mild oral narcotic analgesics. Complications included one case of transient respiratory depression, one pump pocket infection, and one pump failure. The morphine dose required to maintain analgesia increased over time in all patients treated. This is a safe and effective method of pain management in patients with head and neck cancer. It is useful as well in patients who have intractable pain that cannot be managed through an intrathecal route because of a contraindication to lumbar puncture or an inaccessible subarachnoid space.
authors.affiliation: Department of Surgery, College of Medicine, Howard University, Washington, District of Columbia.
authors.forename: G C
authors.initials: GC
authors.lastname: Dennis
authors.forename: R L
authors.initials: RL
authors.lastname: DeWitty
mesh_terms: D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D007260:Infusion Pumps / Q000009:adverse effects; D007276:Injections, Intraventricular; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D009020:Morphine