title: Identification of a group of Haemophilus influenzae penicillin-binding proteins that may have complementary physiological roles.
abstract: [35S]penicillin bound to different Haemophilus influenzae proteins in assays performed at 20, 37, or 42 degrees C. Penicillin-binding proteins 3a, 3b, 4, and 4' formed a group characterized by their affinity for moxalactam, cefotaxime, and piperacillin. Penicillin-binding protein 4' showed specific properties that may reflect its complementary role in septation.
authors.affiliation: Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285-0438.
authors.forename: F
authors.initials: F
authors.lastname: Malouin
authors.forename: T R
authors.initials: TR
authors.lastname: Parr
authors.forename: L E
authors.initials: LE
authors.lastname: Bryan
mesh_terms: D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D003470:Culture Media; D006193:Haemophilus influenzae / Q000378:metabolism*; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism* / Q000502:physiology; D010400:Penicillin G / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism*; D010458:Peptidyl Transferases; D013050:Spectrometry, Fluorescence; D013462:Sulfur Radioisotopes; D013696:Temperature
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D003470:Culture Media; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D013462:Sulfur Radioisotopes; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D010400:Penicillin G