title: The early response of articular cartilage to ACL transection in a canine model.
abstract: Ten outbred dogs underwent unilateral transection of the anterior cruciate ligament of the knee (stifle) joint with sacrifice from 6 to 27 weeks post-operatively. On the operated side were found mild degenerative changes histologically and evidence of increased proteoglycan synthesis with no net loss of uronic acid. Water content was increased in the medial femoral condyle. Contralateral knees showed evidence of increased proteoglycan synthesis and uronic acid content without histologic cartilage lesions.
authors.affiliation: Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Canada.
authors.forename: R G
authors.initials: RG
authors.lastname: Johnson
authors.forename: A R
authors.initials: AR
authors.lastname: Poole
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D004285:Dogs; D005260:Female; D005269:Femur / Q000378:metabolism; D005270:Femur Head / Q000473:pathology; D006651:Histocytochemistry; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000502:physiology*; D008022:Ligaments / Q000502:physiology*; D008297:Male; D011859:Radiography; D013431:Sulfates / Q000378:metabolism; D013462:Sulfur Radioisotopes; D013977:Tibia / Q000378:metabolism / Q000473:pathology; D014574:Uronic Acids / Q000378:metabolism
chemical_list: D013431:Sulfates; D013462:Sulfur Radioisotopes; D014574:Uronic Acids