title: Implantable rate-responsive counterpulsation assist system.
abstract: To apply the potential energy source available from skeletal muscle in cardiac assistance, we developed an implantable counterpulsation assist system. This study reports the results using this implantable counterpulsation assist system in an acute in vivo animal model. Twelve dogs had a dual-chambered, extraaortic counter-pulsation pump anastomosed in parallel to the thoracic aorta. The left latissimus dorsi muscle was used to power the pump. A newly developed implantable stimulator was used to make the muscle contract in synchrony with the diastolic phase. The unique feature of this stimulator is its ability to adjust timing of muscle contraction according to changing heart rates. The stimulator is also able to detect arrhythmias, and as a safety measure, shuts down until a normal rhythm is resumed. During counterpulsation assist with the implantable counterpulsation assist system, diastolic pressure increased an average of 34 mm Hg from baseline, equivalent to a 69% augmentation. Systolic peak pressure decreased an average of 10 mm Hg, equivalent to an 11% unloading. With induced heart rate changes, the implantable counterpulsation assist system readjusted its timing, maintaining optimal counterpulsation without systolic interference. Induced ventricular tachycardia resulted in immediate shutdown of the stimulator until resumption of a normal rhythm. The feasibility of using an intraaortic balloon pump console as back-up was also demonstrated. Excellent counterpulsation was obtained with either muscle power or balloon pump console. We conclude that the implantable counterpulsation assist system can provide effective counterpulsation assist and has the potential for continuous cardiac support.
authors.affiliation: Division of Cardiovascular and Thoracic Surgery, McGill University, Montreal, Canada.
authors.forename: C M
authors.initials: CM
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Hill
authors.forename: M
authors.initials: M
authors.lastname: Colson
authors.forename: C
authors.initials: C
authors.lastname: Desrosiers
authors.forename: R C
authors.initials: RC
authors.lastname: Chiu
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D015908:Counterpulsation / Q000295:instrumentation / Q000379:methods*; D004285:Dogs; D011211:Electric Power Supplies; D004558:Electric Stimulation / Q000295:instrumentation; D006339:Heart Rate / Q000502:physiology; D007423:Intra-Aortic Balloon Pumping; D009132:Muscles / Q000502:physiology; D019736:Prostheses and Implants; D013610:Tachycardia / Q000503:physiopathology