title: Herpes simplex virus infection in heart-lung transplant recipients.
abstract: We report our experience of herpes simplex virus infection in a series of 51 recipients of heart lung transplantation (HLT). Nine patients, all of whom were seropositive for the virus preoperatively, developed HSV infection. Seven episodes of culture-proved mucocutaneous HSV infection without evidence of pulmonary involvement occurred in four patients. Six episodes of HSV pneumonia were seen in a further five patients, one of whom died. Diagnosis of HSV pneumonia was by histological appearances on transbronchial biopsy, together with culture of lung tissue or bronchoalveolar lavage. Concomitant cytomegalovirus infection occurred in four patients. All patients who developed HSV pneumonia did so within the first two postoperative months; in four patients following augmented immunosuppression. We now suggest that HLT recipients who are HSV antibody-positive should receive prophylactic acyclovir for the first two months after surgery and at times of augmented immunosuppression.
authors.affiliation: Heart-Lung Transplant Research Unit, Papworth Hospital, Cambridge, United Kingdom.
authors.forename: R L
authors.initials: RL
authors.lastname: Smyth
authors.forename: T W
authors.initials: TW
authors.lastname: Higenbottam
authors.forename: J P
authors.initials: JP
authors.lastname: Scott
authors.forename: T G
authors.initials: TG
authors.lastname: Wreghitt
authors.forename: S
authors.initials: S
authors.lastname: Stewart
authors.forename: C A
authors.initials: CA
authors.lastname: Clelland
authors.forename: J P
authors.initials: JP
authors.lastname: McGoldrick
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D016041:Heart-Lung Transplantation; D006561:Herpes Simplex / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology*
chemical_list: D000212:Acyclovir