title: Long-term follow-up after leptospirosis.
abstract: Human leptospirosis is an infectious disease that is a substantial problem in the Third World, but it can occur in developed countries as well. Survivors of the acute disease are considered to recover without sequelae, though little literature exists on long-term follow-up among these patients. Eleven patients, at an average of 22 years after acute leptospirosis, were reevaluated for possible delayed sequelae. Results showed that liver and renal disease had resolved, but headache and ophthalmic sequelae persisted. Even though the number of patients involved in this study is small, it appears that the eyes, particularly the anterior chambers, may be the site of continuing morbidity after acute human leptospirosis. The pathogenesis for persistent headache is not known.
authors.affiliation: Rusinow Department of Internal Medicine C, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Shpilberg
authors.forename: Y
authors.initials: Y
authors.lastname: Shaked
authors.forename: M K
authors.initials: MK
authors.lastname: Maier
authors.forename: D
authors.initials: D
authors.lastname: Samra
authors.forename: Y
authors.initials: Y
authors.lastname: Samra
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000372:Agglutination Tests; D000907:Antibodies, Bacterial / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000150:complications; D006801:Humans; D007922:Leptospirosis / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014605:Uveitis / Q000209:etiology
chemical_list: D000907:Antibodies, Bacterial