A unified model of eukaryotic chromosomes.
A revised model of DNA packaging into chromosomes is presented. Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains. The transitions between euchromatic, heterochromatic and metaphase states are explained simply. Molecular and physical properties of chromosomal bands, and their correlation with specific DNA sequence motifs are discussed.
Manuelidis
L
L
Section of Neuropathology, Yale University Medical School, New Haven, Connecticut 06510.
Chen
T L
TL
D000818:Animals; D002871:Chromosome Banding; D002875:Chromosomes / Q000648:ultrastructure*; D004247:DNA / Q000502:physiology; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000648:ultrastructure; D006801:Humans; D007399:Interphase; D008677:Metaphase; D008957:Models, Genetic; D012854:Sister Chromatid Exchange / Q000502:physiology
D004247:DNA