Evidence for the role of spinal cord systems in Parkinson's disease-associated pain.
A patient with Parkinson's disease had severe levodopa-associated leg pain in a beginning-of-dose and peak-dose pattern. Local anesthetic block of the lumbar sympathetic chain or differential epidural block did not alter the pain. Spinal anesthesia abolished the pain. We postulate that levodopa-associated pain in Parkinson's disease either originates in or is mediated by spinal cord dopaminergic systems.
Sage
J I
JI
Department of Neurology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick 08903.
Kortis
H I
HI
Sommer
W
W
D000368:Aged; D004421:Dystonia / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D013116:Spinal Cord / Q000503:physiopathology*
D007980:Levodopa