title: The in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate and other parameters in human urine.
abstract: In this study, an efficient microtechnique (gel crystallization method) was used to investigate the in-vivo effect of sodium-potassium citrate on the crystal growth rate of calcium oxalate (Vcr) in human urine samples of 6 healthy volunteers. With a daily dose of 3 X 11 mmol of alkali citrate, Vcr decreased by 70%. This could have been due to the decrease of calcium excretion, which caused 50-60% of the total change, and to the increase of citrate and pH, each contributing about 20-25% to the decline of Vcr. The findings explain the clinical advantages of alkali citrates in the prevention of recurrent calcium oxalate stone formation.
authors.affiliation: University Clinic Marburg, Department of Urology, Marburg/Lahn, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Achilles
authors.forename: D
authors.initials: D
authors.lastname: Schulze
authors.forename: C
authors.initials: C
authors.lastname: Schalk
authors.forename: G
authors.initials: G
authors.lastname: Rodeck
mesh_terms: D000328:Adult; D002129:Calcium Oxalate / Q000652:urine*; D002951:Citrates / Q000494:pharmacology* / Q000627:therapeutic use*; D019343:Citric Acid; D003460:Crystallization; D006801:Humans; D008297:Male; D014545:Urinary Calculi / Q000517:prevention & control*
chemical_list: D002951:Citrates; D002129:Calcium Oxalate; D019343:Citric Acid