title: [Electrophysiologic effects of orally administered amiodarone].
abstract: The authors made an invasive electrophysiological examination of the heart before and after administration of amiodarone by the oral route in 18 patients (15 men and 3 women). Amiodarone was administered in maintenance doses of 200 or 400 mg/day for 3 to 13 months (mean 4.7 months). Comparison of values revealed a significant protraction of R-R, P-Q and QRS intervals on the surface ECG. A-H and H-V intervals on the electrogram of the bundle of His as well as effective refractory periods of the ventricular myocardium were significantly protracted. During high-frequency stimulation of the atria the frequency at which an a-v block grade II type I develops declined. No significant changes developed in Q-Tc intervals on the surface ECG, the PA-A on the electrogram of the bundle of His and in the corrected recovery period of the s-a node.
authors.affiliation: II. Katedra interních oborů, farmakologie a lékarské biochemie lékarské fakulty Univerzity Karlovy, Hradec Králové.
authors.forename: M
authors.initials: M
authors.lastname: Pleskot
authors.forename: V
authors.initials: V
authors.lastname: Pidrman
authors.forename: P
authors.initials: P
authors.lastname: Tilser
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology*; D002036:Bundle of His / Q000187:drug effects / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000638:Amiodarone
vernacular_title: Elektrofyziologické úcinky amiodaronu podávaného per os.