title: Scintigraphic detection of bone and joint infections with indium-111-labeled nonspecific polyclonal human immunoglobulin G.
abstract: The utility of indium-111-(111In) labeled immunoglobulin G (IgG) to detect infection of bone and adjacent tissues was investigated. Proof of infection was obtained by cultures taken at surgery. All 32 patients showed focally increased uptake on the technetium-99m- (99mTc) methylene diphosphonate (MDP) skeletal scintigraphies. Labeled immunoglobulin correctly identified presence, location, extent and soft-tissue involvement of the suspected inflammatory site. In these patients, focally increasing accumulation was noted over 48 hr. Discrimination between infection and sterile inflammatory lesions was not possible. Two fractures, 6-mo-old, and an aseptic loosening of a total-hip prosthesis were not visualized. Side effects after the immunoglobulin administration were not observed. Radiolabeled immunoglobulin is a new and safe radiopharmaceutical for the investigation of infectious bone and joint disease. The sensitivity of this agent appears at least as high as that of labeled leukocytes. However, labeled immunoglobulin can easily be prepared in every nuclear medicine department.
authors.affiliation: University Hospital Nijmegen, Department of Nuclear Medicine, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Oyen
authors.forename: R A
authors.initials: RA
authors.lastname: Claessens
authors.forename: J R
authors.initials: JR
authors.lastname: van Horn
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
mesh_terms: D001170:Arthritis, Infectious / Q000000981:diagnostic imaging*; D001424:Bacterial Infections / Q000000981:diagnostic imaging*; D015299:Discitis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
chemical_list: D007074:Immunoglobulin G; D007205:Indium Radioisotopes; D004369:Pentetic Acid; D013669:Technetium Tc 99m Medronate