Development of a potentially wearable glucose sensor for patients with diabetes mellitus: design and in-vitro evaluation.
A potentially wearable glucose sensor was developed, consisting of an oxygen electrode as detector and a dynamic enzyme perfusion system as selector. The selector is a hollow fibre, which can be placed subcutaneously and dialyses glucose from tissue fluid. In this design the problems of enzyme instability and oxygen limitation might be circumvented. The sensor measures glucose reliably for over two weeks, provided a new 10 ml syringe containing a glucose oxidase solution is connected to the system each day.
Schoonen
A J
AJ
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, University of Groningen, The Netherlands.
Schmidt
F J
FJ
Hasper
H
H
Verbrugge
D A
DA
Tiessen
R G
RG
Lerk
C F
CF
D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood*; D005069:Evaluation Studies as Topic; D005949:Glucose Oxidase; D006801:Humans; D066298:In Vitro Techniques; D010100:Oxygen; D019736:Prostheses and Implants; D013997:Time Factors
D001786:Blood Glucose; D005949:Glucose Oxidase; D010100:Oxygen