title: Effects of cigarette smoking and dietary lipids on rat lipoprotein metabolism.
abstract: The effects of cigarette smoke inhalation on rat lipoprotein metabolism have been examined. Rats were subjected to cigarette smoke exposure over a 3-week period (two 1-h sessions/day) using a Bat-Mason inhalation machine. Rats exposed to cigarette smoke showed a decrease in total serum triglyceride and an increase in very low density lipoprotein cholesterol (VLDL-C). Administration of cigarette smoke to rats fed a saturated fat and cholesterol enriched diet also led to an increase in VLDL-C and a decrease in total serum triglycerides compared to controls. In addition, cigarette smoke exposure to animals fed the lipid enriched diet caused a decrease in high density lipoprotein cholesterol (HDL-C). Pair-feeding experiments indicated that the increase in VLDL-C and the decrease in HDL-C could not be solely attributed to the reduction in food intake and the small decrease in growth rate observed following cigarette smoke exposure. The changes observed in VLDL-C and HDL-C are at least qualitatively similar to the changes seen in human smokers compared to non-smokers.
authors.affiliation: Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Vic., Australia.
authors.forename: V
authors.initials: V
authors.lastname: Maida
authors.forename: G J
authors.initials: GJ
authors.lastname: Howlett
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism*; D015243:Cholesterol, VLDL / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF; D012907:Smoking / Q000097:blood*
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats