Pulmonary capillary dynamics and fluid distribution after burn and inhalation injury.
A non-linear macroscopic mathematical model is described for the simulation of the different mechanisms that regulate the pulmonary capillary dynamics in patients with thermal injury. The techniques used in the construction of the model are those of 'system's dynamics'. This model has been incorporated into a patient simulator, which makes it possible to analyse the fluid and protein exchanges in a burn patient. The regulating mechanisms involved are: the pulmonary circulation, the fluid and protein transfer between the plasma and the interstitial space at the pulmonary capillary level, and the pulmonary lymphatic system. As a result of the sensitivity analyses of the model we propose that, for the simulation of the effects of an inhalation injury at the pulmonary capillary level, the parameters to be altered will be the pulmonary capillary permeability coefficient for proteins and the pulmonary capillary surface damaged by the injury. To verify the validity and utility of the model, the clinical progress of a series of burn patients with lung injuries has been compared with the results obtained using simulation.
Roa
L
L
Dpto. de Ingenieria de Sistemas y Automática, Universidad de Sevilla, Spain.
Gómez-Cia
T
T
Cantero
A
A
D002056:Burns / Q000503:physiopathology*; D002196:Capillaries / Q000503:physiopathology; D002199:Capillary Permeability; D005110:Extracellular Space / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008962:Models, Theoretical; D011506:Proteins / Q000032:analysis; D011654:Pulmonary Edema / Q000503:physiopathology; D012189:Retrospective Studies; D015208:Smoke Inhalation Injury / Q000503:physiopathology*
D011506:Proteins