[Synthesis and biochemical properties of new 10-acyl derivatives of dithranols: acetylsalicyldithranol and 1-acetyllactyldithranol].
By reaction of the corresponding acid chlorides of acetylsalicylic acid (8) and L-acetyllactic acid (5) with dithranol (1) in toluene and collidin or pyridine as a base two new 10-acylderivatives of (1) were prepared: L-acetyllactyldithranol (2) and acetylsalicyldithranol (3). Both derivatives strongly inhibited the enzyme glucose-6-phosphate dehydrogenase, indicating possible antipsoriatic activity.
Berset
J D
JD
Dermatologische Klinik, Universität Bern.
Krebs
A
A
D000875:Anthralin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*
C063604:10-acetyllactyldithranol; C063603:10-acetylsalicyldithranol; D005954:Glucosephosphate Dehydrogenase; D000875:Anthralin
Synthese und biochemische Eigenschaften von weiteren 10-Acylderivaten des Dithranols: Acetylsalicyldithranol und L-Acetyllaktyldithranol.