Association between HLA-DR antigens and rheumatoid arthritis in Arabs.
Eighty five Arab patients with classical and definite rheumatoid arthritis were typed to determine the prevalence of HLA A, B, C, and DR antigens. A significant increase in the prevalence of HLA-A10, B8, B21, and DR3 was found in comparison with a control population matched for age and sex. HLA-DR5 was significantly decreased in the patient group. The classical association of HLA-DR4 with rheumatoid arthritis could not be confirmed in the Arab patients resident in Kuwait, supporting reported observations in different ethnic groups of associations with HLA antigens other than HLA-DR4 and indicating a heterogeneous genetic susceptibility to rheumatoid arthritis.
Sattar
M A
MA
Department of Medicine, Kuwait University, Safat, Arabian Gulf.
al-Saffar
M
M
Guindi
R T
RT
Sugathan
T N
TN
Behbehani
K
K
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015795:HLA-B8 Antigen / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis*; D015803:HLA-DR3 Antigen / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D006801:Humans; D007730:Kuwait; D008297:Male; D015995:Prevalence; D012306:Risk
D015234:HLA-A Antigens; C039682:HLA-A10 antigen; D015235:HLA-B Antigens; C063569:HLA-B21 antigen; D015795:HLA-B8 Antigen; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015805:HLA-DR5 Antigen