title: Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio.
abstract: Samples sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1 - alpha)% confidence interval for the log odds ratio will not exceed a specified width 2 delta with specified probability (1 - gamma). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.
authors.affiliation: Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.
authors.forename: G A
authors.initials: GA
authors.lastname: Satten
authors.forename: L L
authors.initials: LL
authors.lastname: Kupper
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D013223:Statistics as Topic