title: Adenovirus 41 growth in semi-permissive cells shows multiple-hit kinetics.
abstract: Adenovirus type 41 infection of semi-permissive Chang conjunctival cells, monitored by fluorescent focus assay, followed multiple-hit kinetics. In non-permissive human cells, type 41 showed infectivity with two-hit kinetics in the presence of type 2. Type 41 infectivity was seen to be directly proportional to input concentration (one-hit) only in 293 cells, a continuous human line expressing Ad 5 E1 products.
authors.affiliation: Department of Virology, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: C T
authors.initials: CT
authors.lastname: Tiemessen
authors.forename: A H
authors.initials: AH
authors.lastname: Kidd
mesh_terms: D000260:Adenoviruses, Human / Q000254:growth & development*; D002478:Cells, Cultured; D006378:Helper Viruses / Q000254:growth & development; D006801:Humans; D007700:Kinetics; D014776:Virus Cultivation