title: Kinetic fate of potassium embelate, a non-narcotic centrally acting analgesic after oral and intravenous administration.
abstract: The pharmacokinetics of oral and intravenous potassium embelate (20 mg/kg) was studied in rats. The results revealed that this compound follows a biexponential kinetic pattern. Absorption was complete (bioavailability 97%) and fast. The disposition half-life is 9.5 h on intravenous and 11 h on oral administration. High concentrations of the drug were found in brain between 0.25 and 2 h, which is in agreement with its pharmacological action. The kidney plays a major role in the excretion of the drug.
authors.affiliation: Regional Research Laboratory, Jammu Tawi, India.
authors.forename: U
authors.initials: U
authors.lastname: Zutshi
authors.forename: S C
authors.initials: SC
authors.lastname: Sharma
authors.forename: J L
authors.initials: JL
authors.lastname: Kaul
authors.forename: C K
authors.initials: CK
authors.lastname: Atal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016227:Benzoquinones; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D011809:Quinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D016227:Benzoquinones; D011809:Quinones; C010945:embelin