Gliomas following low-dose irradiation to the head report of three cases.
Three patients developed cerebral gliomas decades after exposure to low-dose x-ray irradiation in childhood for the treatment of tinea capitis. One of the patients had a glioblastoma multiforme concomitant with multiple intracranial meningiomas, a condition highly correlated with previous irradiation. The other tumors were malignant cerebellar astrocytoma and a diffuse cerebral astrocytoma. We review the evidence suggesting that low-dose irradiation is involved in the pathogenesis of gliomas.
Soffer
D
D
Department of Pathology, Hadassah University Hospital, Jerusalem, Israel.
Gomori
J M
JM
Pomeranz
S
S
Siegal
T
T
D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*