[The dependence of estradiol and progesterone reception in the endometrium on its histological structure in women with the syndrome of luteal phase failure].
A study of the level of the sex steroid receptors in the endometrium of women with the syndrome of insufficiency of the luteal phase of the cycle (ILP-syndrome) has shown that disorders of receptor processes affect, first of all, progesterone receptors. An increase in a degree of a delay of endometrial development was accompanied by a rise of the level of progesterone in the endometrium which depended on the estradiol-progesterone ratio in the circulation, detectable on the 20th day of the menstrual cycle. The ILP-syndrome is characterized by the sufficient induction of progesterone receptors at the end of the proliferative--the beginning of the luteal phase of the cycle and by their insufficient inhibition with a low level of progesterone in the middle of the luteal phase. Insufficient synthesis of receptors as a result of sharp hypoestrogenemia is less frequent. The primary affection of the receptor apparatus as a cause of the ILP-syndrome against a normal hormonal background in the examinees was undetectable.
Savchenko
O N
ON
Arutiunian
N A
NA
Beskrovnaia
N I
NI
Levchenko
R G
RG
Khrustaleva
G F
GF
D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D004717:Endometrium / Q000032:analysis* / Q000378:metabolism / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology; D008183:Luteal Phase / Q000502:physiology*; D009869:Oophoritis / Q000503:physiopathology; D011374:Progesterone / Q000097:blood; D011959:Receptors, Estradiol / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012488:Salpingitis / Q000503:physiopathology; D013577:Syndrome; D013997:Time Factors
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol
Zavisimost' retseptsii éstradiola i progesterona v éndometrii ot ego gistostruktury u zhenshchin s sindromom nedostatochnosti liuteinovoĭ fazy tsikla.