title: Failure to acquire an inhibitory task following seizure-induced brain damage.
abstract: Male rats that had displayed limbic seizures following a single pair of systemic injections of lithium and pilocarpine were trained 2 months later on an operant schedule that required differential low rates of responding (DRL). The seizured rats never acquired schedules that required either 6-sec. or 12-sec. inhibition of responses following a reward; these rats displayed more perseverative responding and shorter interresponse times than controls. Histomorphology indicated severe brain damage primarily within the entorhinal cortices (and adjacent amygdala) and dorsal thalamus.
authors.affiliation: Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Harrigan
authors.forename: O
authors.initials: O
authors.lastname: Peredery
authors.forename: M A
authors.initials: MA
authors.lastname: Persinger
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*