title: Pregnancy increases cardiovascular toxicity to cocaine.
abstract: The effects of intravenous cocaine on heart rate and blood pressure were studied in pregnant and oophorectomized nonpregnant ewes. In response to intravenous cocaine doses of 1.0 and 2.0 mg/kg, both pregnant and nonpregnant ewes demonstrated dose-dependent increases in systolic, diastolic, mean arterial, and pulse pressures with return to baseline by 30 to 60 minutes after cocaine administration. However, at both doses (1.0 and 2.0 mg/kg) pregnant ewes demonstrated greater increases in mean arterial pressure (+29.6%, +48.7%) than nonpregnant ewes (+15.6%, +27.7%) during the first 5 minutes after cocaine administration. Thereafter the responses were similar. Thus pregnancy increases the cardiovascular toxicity to cocaine.
authors.affiliation: Department of Obstetrics-Gynecology, Strong Memorial Hospital, School of Medicine and Dentistry, University of Rochester, NY 14642.
authors.forename: J R
authors.initials: JR
authors.lastname: Woods
authors.forename: M A
authors.initials: MA
authors.lastname: Plessinger
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D003042:Cocaine / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D012756:Sheep
chemical_list: D011941:Receptors, Adrenergic; D011374:Progesterone; D003042:Cocaine