title: SF2487, a new polyether antibiotic produced by Actinomadura.
abstract: A new antibiotic SF2487 has been isolated from the culture broth of Actinomadura sp. SF2487. The structure of antibiotic SF2487 was determined by spectroscopic analyses of the sodium salt and X-ray diffraction analysis of the silver salt. The antibiotic represents a new member of polyether group antibiotics known as the acyltetronic acid type 4. The antibiotic is weakly active against Gram-positive bacteria and exhibits antiviral activity against influenza virus in vitro.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hatsu
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Miyadoh
authors.forename: H
authors.initials: H
authors.lastname: Watabe
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Orikasa
authors.forename: K
authors.initials: K
authors.lastname: Kajii
authors.forename: T
authors.initials: T
authors.lastname: Shomura
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005285:Fermentation; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009618:Nocardiaceae / Q000145:classification / Q000378:metabolism*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; C063728:SF 2487