title: Immunosuppression in patients with metastatic squamous cell carcinoma from the skin.
abstract: Sixteen of 70 patients with metastatic squamous cell carcinoma (SCC) from the skin had evidence of clinical immunosuppression. In addition to patients with lymphoproliferative disorders or renal failure, those with cicatricial pemphigoid and those undergoing chronic oral corticosteroid therapy were identified as being at high risk. Host immune surveillance appears to play a major role in determining the metastatic potential of cutaneous SCC.
authors.affiliation: Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.
authors.forename: S M
authors.initials: SM
authors.lastname: Dinehart
authors.forename: D Z
authors.initials: DZ
authors.lastname: Chu
authors.forename: A W
authors.initials: AW
authors.lastname: Maners
authors.forename: S V
authors.initials: SV
authors.lastname: Pollack
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000276:immunology* / Q000556:secondary; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007676:Kidney Failure, Chronic / Q000150:complications; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000276:immunology; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones