title: Fulminant hepatic failure in poisoning due to ingestion of T 61, a veterinary euthanasia drug.
abstract: A patient developed fulminant hepatic failure 48 h after the ingestion of T 61, a veterinary euthanasia drug which contains both general and local anesthetics, a neuromuscular blocking agent, and dimethylformamide (DMF) as a solvent. This is the first report of such severe hepatic manifestation in T 61 poisoning, the most common symptoms of which are early coma and respiratory failure due to the anesthetic and the neuromuscular blocking agent. In a very few cases mild and transitory symptoms of hepatic insufficiency have been observed. In this case the fulminant hepatic failure was due to the high dose (0.6 ml/kg) ingestion of DMF.
authors.affiliation: Department of Intensive Care, Centre Hospitalier Universitaire, Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Nicolas
authors.forename: P
authors.initials: P
authors.lastname: Rodineau
authors.forename: J M
authors.initials: JM
authors.lastname: Rouzioux
authors.forename: I
authors.initials: I
authors.lastname: Tack
authors.forename: S
authors.initials: S
authors.lastname: Chabac
authors.forename: D
authors.initials: D
authors.lastname: Meram
mesh_terms: D000577:Amides; D000641:Ammonia / Q000097:blood; D004126:Dimethylformamide / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D062787:Drug Overdose / Q000150:complications* / Q000628:therapy; D005260:Female; D006501:Hepatic Encephalopathy / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D010976:Platelet Count; D000644:Quaternary Ammonium Compounds; D013406:Suicide, Attempted; D013748:Tetracaine
chemical_list: D000577:Amides; D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; D013748:Tetracaine; C015591:T 61; D000641:Ammonia; D004126:Dimethylformamide