Electrochemical treatment of cancer. II: Effect of electrophoretic influence on adriamycin.
Electrochemical treatment of cancer with DC electrodes changes the microenvironment of the cancer cells by electrophoresis. They may deteriorate and resorb. In larger neoplasms, the effects can be enhanced by electrophoresis of a chemotherapeutic agent. Adriamycin delivered into an electropositive neoplasm electrode will move outwards in the neoplastic area in a high concentration. When given intravenously and the neoplasm electrode is electronegative, the systemic effects may be diminished. The agent is instead accumulated in the neoplastic region in a high concentration. This principle may be used to reduce systemic effects of charged chemotherapeutic compounds. In this preliminary study of cancer in 14 patients, incurable with surgery, radiation treatment, or chemotherapy, beneficial effects were obtained after combined electrochemical treatment and the use of Adriamycin.
Nordenström
B E
BE
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Eksborg
S
S
Beving
H
H
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D002405:Catheterization, Central Venous; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use*; D004563:Electrochemistry; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007478:Iontophoresis / Q000295:instrumentation; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D004317:Doxorubicin