title: [Meningo-encephalomyelitis in Lyme disease].
abstract: A case of isolated central nervous system involvement in Lyme disease is described. A 13 year-old boy developed progressive spastic quadraparesis, chronic lymphocytic meningitis with a low CSF glucose concentration and demyelinating lesions of the white matter on MRI. The diagnosis was proved serologically by high antibody titers against Borrelia burgdorferi (BB) in the serum (1:5, 120) and CSF (1:1,280). There was evidence of specific intrathecal immune response against the BB antigen. The patient was treated with penicillin G and then ceftriaxone. The CSF abnormalities quickly improved but improvement of the neurologic symptoms was gradual and to date still incomplete.
authors.affiliation: Service de Médecine Infantile, C.H.R.U. de Grenoble.
authors.forename: O
authors.initials: O
authors.lastname: Pincemaille
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: I
authors.initials: I
authors.lastname: Wroblewski
authors.forename: P
authors.initials: P
authors.lastname: François
authors.forename: B
authors.initials: B
authors.lastname: Gratacap
authors.forename: A
authors.initials: A
authors.lastname: Joannard
authors.forename: M
authors.initials: M
authors.lastname: Bost
mesh_terms: D000293:Adolescent; D002443:Ceftriaxone / Q000627:therapeutic use; D002648:Child; D004679:Encephalomyelitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008193:Lyme Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy; D010400:Penicillin G / Q000627:therapeutic use
chemical_list: D002443:Ceftriaxone; D010400:Penicillin G
vernacular_title: Méningo-encéphalomyélite de la maladie de Lyme.