Efficacy of cyclosporin A for idiopathic pulmonary fibrosis.
In an 11-year-old girl with severe dyspnoea and cyanosis, idiopathic pulmonary fibrosis (IPF) was diagnosed. The PaO2 of blood could be maintained between 50 mm Hg and 70 mm Hg with a high dose pulse corticosteroid therapy, although this dose could not be reduced. Azathioprine in addition to prednisolone provoked deterioration. Twelve weeks after admission, cyclosporin A (Cs A), a known immunosuppressant, was started together with prednisolone. The PaO2 reverted to normal within 1 month and prednisolone could be tapered off within 6 months. Two years after admission, the patient is free of symptoms on continuous Cs A therapy. This case seems to be the first case successfully treated with Cs A.
Fukazawa
M
M
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kawano
M
M
Hisano
S
S
Ueda
K
K
Matsuba
K
K
D000284:Administration, Oral; D001379:Azathioprine / Q000494:pharmacology; D002648:Child; D003524:Cyclosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000187:drug effects*
D003524:Cyclosporins; D011239:Prednisolone; D001379:Azathioprine