title: A pharmacokinetic study of high-dose metoclopramide suppositories.
abstract: The pharmacokinetics of high-dose rectal metoclopramide have been studied in nine patients after administration of 150-mg suppositories. The results have been compared to the pharmacokinetics of the drug in five patients who received the same dose of metoclopramide intravenously. Administration of a metoclopramide suppository achieved plasma drug concentrations that are associated with the effective treatment of cytotoxic drug-induced nausea and vomiting. In three patients who received the drug by both routes the systemic availability of the suppository appeared to be complete. High-dose metoclopramide suppositories are convenient and may be advantageous in the treatment of medical oncology out-patients.
authors.affiliation: Department of Pharmacy, Heriot-Watt University, Edinburgh, Scotland.
authors.forename: F
authors.initials: F
authors.lastname: Hardy
authors.forename: P S
authors.initials: PS
authors.lastname: Warrington
authors.forename: J S
authors.initials: JS
authors.lastname: MacPherson
authors.forename: S A
authors.initials: SA
authors.lastname: Hudson
authors.forename: G C
authors.initials: GC
authors.lastname: Jefferson
authors.forename: J F
authors.initials: JF
authors.lastname: Smyth
mesh_terms: D000285:Administration, Rectal; D001682:Biological Availability; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009369:Neoplasms / Q000188:drug therapy; D013488:Suppositories
chemical_list: D013488:Suppositories; D008787:Metoclopramide