Effect of alpha-chlorohydrin on in situ pH in rat testis and epididymis.
The effect of the male contraceptive, alpha-chlorohydrin, on in situ pH in seminiferous tubules and epididymal duct of the rat has been studied employing in vivo microelectrode techniques. After eight days of low-dose alpha-chlorohydrin administration (15mg/kg/day), a significant increase in acidity of luminal fluid in seminiferous tubules, proximal caput, middle caput, and proximal cauda epididymidis was observed. Increased acidity in the testis and epididymis may play an important role in the antifertility effect of alpha-chlorohydrin.
Caflisch
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CR
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
DuBose
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TD
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects* / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000502:physiology; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; D000517:alpha-Chlorohydrin