title: The effect of hypermagnesemia on serum levels of osteocalcin in an animal model.
abstract: Using a pregnant goat (Capra hircus) model to study the in vivo effects of hypermagnesemia on serum osteocalcin concentration, magnesium sulfate infusion has been shown to increase circulating levels of osteocalcin. At 2 h after the administration of magnesium sulfate, a 98% increase in Mg2+ concentration over the basal level resulted in: a 38% increase in serum osteocalcin concentration over baseline; a 22% decrease in PTH concentration, and no change in total and ionized calcium concentrations. These in vivo data support previous in vitro results demonstrating that Mg2+ is a potent inhibitor of osteocalcin binding to hydroxyapatite.
authors.affiliation: Department of Pathology, Wilford Hall USAF Medical Center, Lackland AFB, Tex.
authors.forename: F H
authors.initials: FH
authors.lastname: Wians
authors.forename: D M
authors.initials: DM
authors.lastname: Strickland
authors.forename: G D
authors.initials: GD
authors.lastname: Hankins
authors.forename: R R
authors.initials: RR
authors.lastname: Snyder
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006041:Goats; D006706:Homeostasis; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008954:Models, Biological; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000378:metabolism; D011247:Pregnancy
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D008278:Magnesium Sulfate; D002118:Calcium