Susceptibility to fusidic acid among Danish Staphylococcus aureus strains and fusidic acid consumption.
A total of 8176 Danish Staphylococcus aureus strains isolated from cases of bacteraemia during the years 1963 to 1987 were investigated for resistance to fusidic acid. During the whole period 1% of the strains or less were resistant (MIC of 2 mg/l or more). The total Danish consumption of fusidic acid during the same period increased from 0.008 to 0.029 defined daily doses/1000 inhabitants/day. The resistant strains were mainly sporadic isolates with the phage-types and antibiotic-resistance patterns predominant in Denmark at the time of their isolation.
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Staphylococcus Laboratory, Statens Seruminstitut, Copenhagen, Denmark.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001434:Bacteriophage Typing; D003718:Denmark; D004352:Drug Resistance, Microbial; D004363:Drug Utilization; D005672:Fusidic Acid / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D005672:Fusidic Acid