title: Sera from MS patients and normal controls opsonize myelin.
abstract: Fc receptor-dependent myelin phagocytosis has been proposed as a mechanism of demyelination in multiple sclerosis (MS). The object of this study was to determine whether MS patients' sera are more opsonic for myelin than normal controls' sera. Opsonization was tested by culturing thioglycollate elicited murine peritoneal macrophages with 125I-labelled, serum-sensitized bovine central myelin. The two groups of sera were found to opsonize myelin equally well after 30 and 120 min incubations. We conclude that MS patients' sera are not more opsonic for myelin than sera from normal controls.
authors.affiliation: Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark.
authors.forename: P Z
authors.initials: PZ
authors.lastname: Goldenberg
authors.forename: R A
authors.initials: RA
authors.lastname: Troiano
authors.forename: E E
authors.initials: EE
authors.lastname: Kwon
authors.forename: J W
authors.initials: JW
authors.lastname: Prineas
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000276:immunology; D002417:Cattle; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008262:Macrophage Activation; D051379:Mice; D008811:Mice, Inbred DBA; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology; D009186:Myelin Sheath / Q000276:immunology*; D009895:Opsonin Proteins; D010587:Phagocytosis
chemical_list: D001685:Biological Factors; D009895:Opsonin Proteins