title: Effects of melatonin and progesterone administered to ewes in spring and summer.
abstract: Melatonin (MEL) was evaluated for effects on LH, prolactin (PRL) and fertility in spring (Exp. 1, 2) and summer (Exp. 3 to 5). In Exp. 1, 17 ovariectomized ewes bearing estradiol implants were fed 3 mg MEL or vehicle for 44 d beginning May 1. Melatonin decreased (P less than .001) PRL levels but had no effect on LH secretion and response to GnRH. In Exp. 2, 12 ewes each received a 40-d MEL ear implant or a sham implant on March 31. Progesterone-releasing pessaries (CIDR) were applied for 12 d and were withdrawn concomitant with ram joining on May 7. Neither treatment stimulated follicular development or induced estrus or ovulation. Exp. 3 and 4 were contemporary 2 x 2 factorial trials with 24 ewes at each of two locations. Melatonin implants were administered on June 29 and CIDR on July 22. The CIDR were removed and rams (Exp. 3, vasectomized; Exp. 4, fertile) were joined on August 3. Days from introduction of rams to estrus were reduced (P less than .05) by CIDR but not by MEL. All ewes lambed in Exp. 4, and days to estrus and conception were reduced (P less than .001) by CIDR but not by MEL. Exp. 5 was designed like Exp. 4 except that MEL implants were inserted June 20 and rams were joined August 8. Intervals from introduction of rams to estrus were reduced (P less than .01) by both MEL and CIDR treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: University of Minnesota, St. Paul 55108.
authors.forename: J E
authors.initials: JE
authors.lastname: Wheaton
authors.forename: H A
authors.initials: HA
authors.lastname: Pohl
authors.forename: H F
authors.initials: HF
authors.lastname: Windels
mesh_terms: D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism; D012621:Seasons; D012756:Sheep / Q000378:metabolism*
chemical_list: D011374:Progesterone; D011388:Prolactin; D007986:Luteinizing Hormone; D008550:Melatonin