Fatal complications after myelography with meglumine diatrizoate.
A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.
Hilz
M J
MJ
Department of Neurology, University of Erlangen-Nürnberg, Federal Republic of Germany.
Huk
W
W
Schellmann
B
B
Sörgel
F
F
Druschky
K F
KF
D000368:Aged; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009192:Myelography / Q000009:adverse effects*; D009422:Nervous System Diseases / Q000139:chemically induced*; D013128:Spinal Osteophytosis / Q000000981:diagnostic imaging / Q000601:surgery
D003974:Diatrizoate Meglumine