Dose-dependent kinetics of inhaled methylethylketone in man.
Physiologically based stimulation of earlier human inhalation exposure to methylethylketone (MEK) at a concentration of 200 ppm for 4 h suggested that the kinetics were dose-dependent. Two male volunteers were therefore exposed to MEK for 4 h at 3 exposure concentrations: 25, 200 and 400 ppm. Blood MEK concentrations were monitored during and after exposure. The results showed clearly that the kinetics of MEK were dose-dependent at higher exposure concentrations. Simulated exposure to MEK for 8 h suggests that saturation kinetics are reached at an exposure concentration of 50-100 ppm, depending on the physical work load.
Liira
J
J
Turku Regional Institute of Occupational Health, Finland.
Johanson
G
G
Riihimäki
V
V
D000280:Administration, Inhalation; D000328:Adult; D002074:Butanones / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D014018:Tissue Distribution
D002074:Butanones; C005222:methylethyl ketone