title: Increased turnover of very low density lipoprotein triglyceride during treatment with cholestyramine in familial hypercholesterolaemia.
abstract: Kinetics of very low density lipoprotein (VLDL) triglyceride were determined in seven patients with heterozygous familial hypercholesterolaemia, using a 3H-glycerol technique. The study was repeated after 5-7 weeks of therapy with the bile acid-binding resin, cholestyramine. The rate of synthesis of VLDL triglyceride was increased by 85% (P less than 0.05) during resin therapy. Simultaneously, the fractional catabolic rate of VLDL was increased by 40% (P less than 0.02), so that only a moderate increase in plasma concentration was observed. Repeated measurements of VLDL size by electron microscopy (before, 1 week, and 5-7 weeks after initiation of therapy) indicated that a transient increase in VLDL size occurred in response to cholestyramine. The results are consistent with a stimulatory effect of bile acid sequestrants on VLDL triglyceride production and indicate that, in most subjects, a compensatory increase in VLDL triglyceride removal occurs.
authors.affiliation: Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Angelin
authors.forename: B
authors.initials: B
authors.lastname: Leijd
authors.forename: R
authors.initials: R
authors.lastname: Hultcrantz
authors.forename: K
authors.initials: K
authors.lastname: Einarsson
mesh_terms: D000328:Adult; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D005260:Female; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; D002792:Cholestyramine Resin