title: Tobacco smoke suppresses T cells but not antigen-presenting cells in the lung-associated lymph nodes.
abstract: Chronic inhalation of cigarette smoke in mice preferentially inhibited the antigen-specific T-cell proliferative response of lung-associated lymph nodes compared to anatomically distant lymph nodes. Cell mixing experiments demonstrated that the defect in smoked mice resulted from an abnormality in T-lymphocyte function. In contrast, the activity of antigen-presenting cells was similar in smoked and sham-smoked control animals. These results suggest that T-cell function in lung-associated lymphoid tissue may be inhibited in smokers, leading to a localized predisposition to respiratory tract infections.
authors.affiliation: Department of Microbiology and Immunology, University of Kentucky Medical Center, Lexington 40536-0084.
authors.forename: J C
authors.initials: JC
authors.lastname: Chang
authors.forename: S G
authors.initials: SG
authors.lastname: Distler
authors.forename: A M
authors.initials: AM
authors.lastname: Kaplan
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D010947:Plants, Toxic; D012906:Smoke / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology*; D014026:Nicotiana
chemical_list: D012906:Smoke