Effects of 2'-deoxycoformycin on HL-60 cell differentiation, adenosine deaminase, and oligoadenylate synthetase.
There is evidence that 2'-deoxycoformycin (DCF) functions as a differentiating agent. We examined the effects of DCF on the differentiation of HL-60 cells, a standard model of leukemic cell differentiation. DCF did not induce morphologic or histochemical evidence of differentiation, nor did it interact with retinoic acid, 1,25-dihydroxyvitamin D3, or interferon-gamma in inducing differentiation. Furthermore, DCF and agents that differentiated HL-60 cells had opposing effects on adenosine deaminase and 2',5'-oligoadenylate synthetase activity.
Triozzi
P L
PL
Department of Medicine, Ohio State University, Columbus 43210.
Vicstein
F
F
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D007942:Leukemia, Experimental / Q000473:pathology*; D009700:Nucleoside Deaminases / Q000378:metabolism*; D015649:Pentostatin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D015649:Pentostatin; D015088:2',5'-Oligoadenylate Synthetase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase