title: Combined cervicothoracic approach in thymectomy for myasthenia gravis.
abstract: Thymectomy was performed for myasthenia gravis on 30 patients, using a new approach with a collar incision which gave full exposure of the retrothyroid space and was directly connected to a median sternotomy. The thymus was removed en bloc without pleural incision. There was no perioperative mortality and the only complications were transient respiratory insufficiency in two cases. The postoperative hospital stay was 3-9 (mean 5.8) days. The effect of thymectomy was evaluated after 2-8 years at the Department of Neurology, when changes in symptoms (stages I-IV) or medication (need for cholinesterase inhibitors) were registered. The total clinical improvement rate was 97%, with 3% of the patients improved three stages, 33% two stages and 60% one stage compared with the preoperative classification. Twenty patients (67%) were asymptomatic at follow-up and six (20%) also required no medication. The medication need was reduced in 70% of cases (mean reduction 42%). Our cervicothoracic approach resulted in the same rate of improvement as in studies using more extensive transsternal procedures, but the morbidity was lower, with no complications requiring prolonged hospital stay. The morbidity was also less than after only transcervical procedures aiming to perform total thymectomy--a prerequisite for maximal and lasting benefit from surgery. Moreover, as this cervicothoracic approach is simple and safe, it can be recommended as an option in the surgical management of myasthenia gravis.
authors.affiliation: Department of Surgery, University Hospital, Linköping, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lennquist
authors.forename: L
authors.initials: L
authors.lastname: Andåker
authors.forename: B
authors.initials: B
authors.lastname: Lindvall
authors.forename: S
authors.initials: S
authors.lastname: Smeds
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004210:Dissection; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D012008:Recurrence; D013934:Thymectomy / Q000379:methods* / Q000592:standards
chemical_list: D011729:Pyridostigmine Bromide