Prediction of infusion rates: computer study.
The administration of two test doses in the ratio 1:0.5 has been shown to provide sufficient data (time intervals) to predict the infusion rate necessary to maintain the concentration of a drug at the therapeutic threshold in a two-compartment pharmacokinetic model. If the relationship between the durations of action of the test doses is linear, only one test dose may be needed to predict the infusion rate.
Harrison
M J
MJ
Auckland Hospital, New Zealand.
D003201:Computers; D006801:Humans; D007262:Infusions, Intravenous; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations