title: Preliminary toxicity studies on ethanol extracts of the aerial parts of Artemisia abyssinica and A. Inculta in mice.
abstract: Ethanolic extracts of the aerial parts of Artemisia abyssinica and A. inculta were subjected to acute toxicity observations in mice for 24 h and chronic toxicity evaluation for 3 months. External morphological changes, visceral toxicity, haematological changes, spermatogenic dysfunction and effect on body weight and vital organ weight were recorded. In both the chronically treated groups, no significant acute mortality was observed up to 3 g/kg p.o. There was no weight gain in A. abyssinica chronically-treated mice while the weight gain of A. inculta-treated animals matched that of the control group. Significant sperm damage was observed in A. abyssinica-treated mice while A. inculta failed to produce any significant spermatotoxic effect.
authors.affiliation: Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: S
authors.initials: S
authors.lastname: Qureshi
authors.forename: A M
authors.initials: AM
authors.lastname: Ageel
authors.forename: M A
authors.initials: MA
authors.lastname: al-Yahya
authors.forename: M
authors.initials: M
authors.lastname: Tariq
authors.forename: J S
authors.initials: JS
authors.lastname: Mossa
authors.forename: A H
authors.initials: AH
authors.lastname: Shah
mesh_terms: D000505:Alopecia / Q000139:chemically induced; D000740:Anemia / Q000139:chemically induced; D000818:Animals; D000431:Ethanol; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced; D005832:Genital Diseases, Male / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D012119:Respiration / Q000187:drug effects; D012529:Saudi Arabia; D013268:Stimulation, Chemical
chemical_list: D010936:Plant Extracts; D000431:Ethanol