Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus.
Antibody titers to caprine arthritis-encephalitis virus surface glycoprotein gp135 and core protein p28 in synovial fluid and serum from 35 goats infected for 3 years were compared with the histologic severity of arthritis in these animals. Anti-gp135 antibody titers in synovial fluid and serum directly reflect the severity of carpal arthritis in chronically infected goats.
Knowles
D
D
Animal Disease Research Unit, U.S. Department of Agriculture-Agricultural Research Service, Pullman, Washington 99164-7030.
Cheevers
W
W
McGuire
T
T
Stem
T
T
Gorham
J
J
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D001170:Arthritis, Infectious / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D004660:Encephalitis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D015511:Goat Diseases / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D006041:Goats; D012190:Retroviridae / Q000276:immunology / Q000472:pathogenicity*; D013582:Synovial Fluid / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D014759:Viral Envelope Proteins