title: The effect on uteroplacental blood flow of epidural anaesthesia containing adrenaline for caesarean section.
abstract: The effect on uteroplacental blood flow of an epidural anaesthesia containing adrenaline for caesarean section was investigated in ten healthy women using dynamic placental scintigraphy with indium-113m and a computer-linked gamma camera. The epidural anaesthesia was performed with 18-22 ml bupivacaine 5 mg/ml with adrenaline 2.5 micrograms/ml followed by an i.v. balanced electrolyte infusion of 10 ml/kg b.w. A significant median decrease in the total maternal placental blood flow of 34% was found (P less than 0.01). There was also a significant decrease in maternal mean blood pressure of 3 mmHg (0.4 kPa) (P less than 0.05) and a significant negative correlation between the change in maternal blood pressure and the change in uteroplacental blood flow (r = -0.69, P less than 0.05).
authors.affiliation: Department of Anaesthesiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Skjöldebrand
authors.forename: J
authors.initials: J
authors.lastname: Eklund
authors.forename: N O
authors.initials: NO
authors.lastname: Lunell
authors.forename: L
authors.initials: L
authors.lastname: Nylund
authors.forename: B
authors.initials: B
authors.lastname: Sarby
authors.forename: S
authors.initials: S
authors.lastname: Thornström
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007204:Indium; D007205:Indium Radioisotopes; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011877:Radionuclide Imaging; D014599:Uterus / Q000098:blood supply*
chemical_list: D007205:Indium Radioisotopes; D007204:Indium; C020758:indium trichloride; D004837:Epinephrine