A quantitative structure-activity relationship study for local anesthetic activity of mono-and diaryl-2-quinuclidinylcarbinols.
The local anesthetic activity of a series of arylquinuclidinylcarbinols is shown to be significantly correlated with their lipophilic character, suggesting that lipophilicity is an important factor for the local anesthetic action of drugs.
Gupta
S P
SP
Birla Institute of Technology and Science, Pilani, India.
Saha
R N
RN
Gupta
J K
JK
D000438:Alcohols; D000779:Anesthetics, Local; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011812:Quinuclidines; D013329:Structure-Activity Relationship
D000438:Alcohols; D000779:Anesthetics, Local; D011812:Quinuclidines