6-(substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. I. Racemic 6-ethylidenepenems.
The dehydration of various 6-(1-hydroxyethyl)penems to give E- and Z-6-ethylidenepenems is described. Both isomers have been shown to be potent broad spectrum inhibitors of bacterial beta-lactamases capable of reducing the MIC values of beta-lactam antibiotics such as amoxycillin and cephaloridine against a wide range of resistant organisms.
Basker
M J
MJ
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
Osborne
N F
NF
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams