title: Synthesis and characterization of a ribavirin-3',5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine.
abstract: The synthesis of a pentadecamer of the 5'-phosphate of the antiviral nucleoside ribavirin (1'-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) has been achieved. This homoribopolymer is terminated at the 5'-position with an (6-aminohexyl)phosphate group to permit conjugation to a carrier and at the 3'-position by a thymidine-5'-phosphate. The synthesis was accomplished using the methyl phosphoramidite approach to oligoribonucleotides. The homoribopolymer was insensitive to ribonuclease A but was sensitive to ribonuclease T2 digestion.
authors.affiliation: Bio-Organic Chemistry Laboratory, SRI International, Menlo Park, CA 94025.
authors.forename: M I
authors.initials: MI
authors.lastname: Dawson
authors.forename: A N
authors.initials: AN
authors.lastname: Jina
authors.forename: S
authors.initials: S
authors.lastname: Torkelson
authors.forename: S
authors.initials: S
authors.lastname: Rhee
authors.forename: M
authors.initials: M
authors.lastname: Moore
authors.forename: D A
authors.initials: DA
authors.lastname: Zarling
authors.forename: P D
authors.initials: PD
authors.lastname: Hobbs
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism; D001704:Biopolymers; D055598:Chemical Phenomena; D002621:Chemistry; D004722:Endoribonucleases / Q000378:metabolism; D046911:Macromolecular Substances; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism; D012259:Ribonuclease, Pancreatic / Q000378:metabolism; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000378:metabolism; D013936:Thymidine
chemical_list: D000998:Antiviral Agents; D001704:Biopolymers; D046911:Macromolecular Substances; D011108:Polymers; D012265:Ribonucleotides; C063491:ribavirin 3',5'-phosphate pentadecamer homoribopolymer; D004722:Endoribonucleases; C022543:ribonuclease T(2); D012259:Ribonuclease, Pancreatic; D013936:Thymidine