title: Cerebral palsy: initial experience with Tc-99m HMPAO SPECT of the brain.
abstract: The outlook for children with cerebral palsy is determined by the severity of motor problems and the presence of associated disabilities, in which early detection remains a medical challenge. The authors studied 13 children (aged 13 months to 12 years) with cerebral palsy by means of single photon emission computed tomography (SPECT) of the brain with technetium-99m hexamethylpropyleneamineoxime (HMPAO). In all children with hemiplegia, SPECT demonstrated hypoperfusion in the hemisphere contralateral to the motor deficit. SPECT demonstrated normal findings in patients with mild diplegia; bilateral hypoperfusion in the superior motor cortex in patients with moderate di- or tetraplegia; and bilateral reduction of perfusion in the superior motor, inferior motor, prefrontal, and parietal cortices in patients with severe di- or tetraplegia. Results suggest that Tc-99m HMPAO SPECT of the brain is a valuable complementary tool for thorough neurologic assessment in cerebral palsy.
authors.affiliation: Department of Neurology, St. Pierre Hospital, Free Universities of Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Denays
authors.forename: M
authors.initials: M
authors.lastname: Tondeur
authors.forename: V
authors.initials: V
authors.lastname: Toppet
authors.forename: H
authors.initials: H
authors.lastname: Ham
authors.forename: A
authors.initials: A
authors.lastname: Piepsz
authors.forename: M
authors.initials: M
authors.lastname: Spehl
authors.forename: M
authors.initials: M
authors.lastname: Rubinstein
authors.forename: P
authors.initials: P
authors.lastname: Noel
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002547:Cerebral Palsy / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime