Rapid up- and down-regulation of hexokinase II in rat skeletal muscle in response to altered contractile activity.
An up to 14-fold increase in total hexokinase activity induced by low-frequency stimulation in rat fast-twitch muscle was followed by a rapid decay in enzyme activity after cessation of stimulation. In vivo labeling revealed that these alterations were related to rapid changes in [35S]methionine incorporation into hexokinase II. A recovery period of 15 h after cessation of stimulation was sufficient to normalize the approximately 30-fold elevated [35S]methionine incorporation.
Weber
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FE
Fakultät für Biologie, Universität Konstanz, FRG.
Pette
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D
D000818:Animals; D015536:Down-Regulation; D004558:Electric Stimulation; D006593:Hexokinase / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D015854:Up-Regulation
D006593:Hexokinase