title: In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy.
abstract: We report the recovery of Salmonella typhi that acquired resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and gentamicin subsequent to multiple antibiotic therapy. Escherichia coli and Klebsiella pneumoniae isolates which were recovered from the same stool sample displayed identical resistance patterns. Agarose gel electrophoresis revealed that S. typhi and laboratory-derived transconjugants contained a high-molecular-weight plasmid present in the resistant intestinal bacteria.
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, Baltimore 21201.
authors.forename: R S
authors.initials: RS
authors.lastname: Schwalbe
authors.forename: C W
authors.initials: CW
authors.lastname: Hoge
authors.forename: J G
authors.initials: JG
authors.lastname: Morris
authors.forename: P N
authors.initials: PN
authors.lastname: O'Hanlon
authors.forename: R A
authors.initials: RA
authors.lastname: Crawford
authors.forename: P H
authors.initials: PH
authors.lastname: Gilligan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D003470:Culture Media; D004269:DNA, Bacterial / Q000032:analysis / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008297:Male; D012485:Salmonella typhi / Q000187:drug effects / Q000235:genetics*; D014435:Typhoid Fever / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D004269:DNA, Bacterial