[A comparative study of the therapeutic and reactivating activities of alloxime and dipyroxime in acute poisoning of animals by organophosphate pesticides].
The therapeutic and reactivating activities of a new antidote alloxime were studied as compared with dipiroxime (TMB-4) during oral intoxication of animals by chlorophos and carbophos (LD50). When administered intramuscularly in a dose of 10 mg/kg, alloxime exhibited more pronounced therapeutic and reactivating effects (particularly in the central nervous system) as compared to dipiroxime.
Loboda
Iu I
IuI
D000110:Acetylcholinesterase / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007306:Insecticides / Q000506:poisoning*; D007928:Lethal Dose 50; D008294:Malathion / Q000506:poisoning; D008297:Male; D010091:Oximes / Q000627:therapeutic use*; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014236:Trichlorfon / Q000506:poisoning; D014289:Trimedoxime / Q000627:therapeutic use*
D000931:Antidotes; D007306:Insecticides; D010091:Oximes; D011726:Pyridinium Compounds; D014289:Trimedoxime; C063856:alloxime; D014236:Trichlorfon; D000110:Acetylcholinesterase; D008294:Malathion
Sravnitel'noe izuchenie lechebnoĭ i reaktiviruiushcheĭ aktivnosti alloksima i dipiroksima pri ostrom otravlenii zhivotnykh fosfororganicheskimi pestitsidami.