Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature.
Histamine content in the rat hypothalamus was lower at 4 degrees C and higher at 31 degrees C compared to that at 21 degrees C. Pretreatment with alpha-fluoromethylhistidine, a 'suicide' inhibitor of histamine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31 degrees C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.
Fujimoto
K
K
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sakata
T
T
Ookuma
K
K
Kurokawa
M
M
Yamatodani
A
A
Wada
H
H
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003080:Cold Temperature; D004435:Eating / Q000187:drug effects; D006632:Histamine / Q000378:metabolism / Q000502:physiology*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors; D006358:Hot Temperature; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D008762:Methylhistidines; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D006640:Histidine Decarboxylase