Flunarizine in migraine prophylaxis: efficacy and tolerability of 5 mg and 10 mg dose levels.
The use of flunarizine, a drug which has proven its efficacy in migraine, is often associated with important side effects. The aim of this paper has been to check their incidence at different dose levels (5 mg vs 10 mg). Our data confirm the occurrence of important side effects (in particular weight gain); on the other hand, they emphasize the dose-dependency of the side effects.
Centonze
V
V
Department of Internal Medicine, University of Bari, Italy.
Magrone
D
D
Vino
M
M
Caporaletti
P
P
Attolini
E
E
Campanale
G
G
Albano
O
O
D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005444:Flunarizine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects
D000700:Analgesics; D005444:Flunarizine