Localization of inhibin/activin subunit mRNAs within the primate ovary.
In order to gain further understanding of the physiology of inhibin and activin in the primate, the expression of inhibin/activin subunit mRNAs in the monkey ovary was examined by in situ hybridization. Granulosa cells of small antral follicles were found to express mRNA for the beta B subunit, which decreased to undetectable levels in dominant follicles. In contrast, expression of alpha and beta A subunit mRNAs was detected in granulosa cells of dominant follicles and in corpora lutea, but not in small antral follicles. These results indicate that the expression of the beta A and beta B subunits is differentially regulated during the growth and development of ovarian follicles in the monkey.
Schwall
R H
RH
Department of Pharmacological Sciences, Genetech, Inc., South San Francisco, California 94080.
Mason
A J
AJ
Wilcox
J N
JN
Bassett
S G
SG
Zeleznik
A J
AJ
D028341:Activins; D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D007265:Inhibins / Q000235:genetics* / Q000378:metabolism; D008251:Macaca; D009690:Nucleic Acid Conformation; D006080:Ovarian Follicle / Q000378:metabolism; D010053:Ovary / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D012333:RNA, Messenger; D028341:Activins; D011374:Progesterone; D004958:Estradiol; D007265:Inhibins