Parenteral administration of GM1 ganglioside to presenile Alzheimer patients.
The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 +/- 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 mumol/l were found in 3 patients. The elimination half-life from serum was 60-75 h.
Svennerholm
L
L
Department of Psychiatry and Neurochemistry, Gothenburg University, Sweden.
Gottfries
C G
CG
Blennow
K
K
Fredman
P
P
Karlsson
I
I
Månsson
J E
JE
Toffano
G
G
Wallin
A
A
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D005677:G(M1) Ganglioside / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008875:Middle Aged
D005677:G(M1) Ganglioside