Effect of an endogenous satiety substance, 2-buten-4-olide, on gastric acid secretion and experimental ulceration in rats.
The involvement of a feeding-related endogenous sugar acid, 2-buten-4-olide (2-B4O) on central regulation of gastric acid secretion, and its antiulcer effects on several gastric and duodenal experimental ulcer models were investigated in rats. Spontaneous gastric acid secretion was not affected by 2-B4O at doses below 10 mg/kg. The peripheral secretagogue-stimulated gastric secretions were significantly increased by pretreatment with 2-B4O. Gastric acid secretion induced by 2-deoxy-D-glucose (2-DG) was significantly suppressed by pretreatment with 2-B4O at doses between 0.1 and 100 mg/kg. Gastric and duodenal ulcerations induced by cold stress plus indomethacin, restraint and water immersion stress, pylorus ligation or cysteamine were also inhibited by pretreatment with 2-B4O. The results suggest that antiulcer effects of 2-B4O are due to suppression of gastric acid secretion via reduction of activity of the vagus nerve and gastric-related hypothalamic neurons. Thus, 2-B4O may be useful for treatment of gastroduodenal ulcer.
Arai
I
I
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Usuki-Ito
C
C
Muramatsu
M
M
Otomo
S
S
Shiraishi
T
T
Oomura
Y
Y
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003543:Cysteamine; D003847:Deoxyglucose / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control; D015738:Famotidine / Q000494:pharmacology; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications
D005663:Furans; D015738:Famotidine; D003543:Cysteamine; D002927:Cimetidine; C004511:butenolide; D003847:Deoxyglucose; D015107:4-Butyrolactone