Effect of postnatal hypoxia on ammonia metabolism during the early neonatal period in the rat.
The effect of experimental hypoxia on blood glutamine, glutamate, urea, ammonia, allantoin, hypoxanthine, xanthine, urate, orotate and lactate concentrations and on PO2, PCO2 and pH in term delivered newborn rats during the first 4 h after delivery were studied. Hypoxia increased blood glutamine, glutamate, allantoin and 'xanthines' (hypoxanthine + xanthine + uric acid) concentrations but decreased blood urea and ammonia concentrations. These results suggest that hypoxia inhibited ureogenesis by decreasing the ammonia available for urea synthesis.
Vicario
C
C
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Salamanca, España.
Juanes
M C
MC
Martín-Barrientos
J
J
Medina
J M
JM
D000481:Allantoin / Q000097:blood; D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001784:Blood Gas Analysis; D005971:Glutamates / Q000097:blood; D005973:Glutamine / Q000097:blood; D000860:Hypoxia / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000097:blood; D014970:Xanthines / Q000097:blood
D005971:Glutamates; D007773:Lactates; D014970:Xanthines; D005973:Glutamine; D000481:Allantoin; D000641:Ammonia; D014508:Urea