Chitosan: evaluation of a new hemostatic agent.
Topically applied chitosan fails to improve the control of bleeding in a liver laceration model when compared to pressure alone in both normal and heparinized rats, and both chitosan and pressure alone are significantly less effective in controlling bleeding than the application of thrombin. In addition, our histologic results suggest that there may be an increased inflammatory response by the healing liver following topical application of chitosan.
Kind
G M
GM
Department of General Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Bines
S D
SD
Staren
E D
ED
Templeton
A J
AJ
Economou
S G
SG
D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D006490:Hemostatics; D008099:Liver / Q000293:injuries*; D051381:Rats; D011919:Rats, Inbred Strains
D006490:Hemostatics; D002686:Chitin; D048271:Chitosan