title: Free electron laser irradiation at 200 microns affects DNA synthesis in living cells.
abstract: We describe the effect of a 200-microns wavelength free electron laser beam on the ability of asynchronized and synchronized mammalian tissue culture cells to incorporate tritiated thymidine. Compared to controls (unexposed cells), a significant proportion of exposed cells exhibited a reduction in isotope incorporation. The results suggest that this wavelength may affect DNA synthesis.
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715.
authors.forename: M W
authors.initials: MW
authors.lastname: Berns
authors.forename: W
authors.initials: W
authors.lastname: Bewley
authors.forename: C H
authors.initials: CH
authors.lastname: Sun
authors.forename: P
authors.initials: P
authors.lastname: Templin
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004261:DNA Replication / Q000528:radiation effects*; D004583:Electrons; D005260:Female; D007834:Lasers; D010053:Ovary; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D014316:Tritium; D004247:DNA; D013936:Thymidine