Genetic basis of resistance to trauma in inbred strains of mice.
In this study the resistance to mechanical, thermal, and radiation trauma in four inbred strains of mice (AKR, BALB/c, CBA, and C57Bl/6) was compared with the degree of genetic resemblance, by analyzing the allozyme variabilities of these strains. It was shown that the highest degree of genetic resemblance was among CBA and AKR strains, which correlated with a similar degree of resistance to trauma. On the other hand, BALB/c and C57Bl/6 strains expressed significant differences, both genetically and with respect to the responses to trauma. The hypothesis is introduced that the genetic determination of the resistance to trauma is based on: a) a polygenic control of general physiological homeostasis, with the possibility that b) some specific genes or single loci may contribute more than others to such adaptations of the strains tested.
Radojicić
C
C
Institut of Experimental Medicine, Military Medical Academy, Belgrade, Yugoslavia.
Andrić
B
B
Simović
M
M
Dujić
A
A
Marinković
D
D
D000483:Alleles; D000818:Animals; D002056:Burns / Q000235:genetics / Q000401:mortality; D005260:Female; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics; D008807:Mice, Inbred BALB C / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D008808:Mice, Inbred CBA / Q000235:genetics; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000235:genetics / Q000401:mortality / Q000473:pathology; D014947:Wounds and Injuries / Q000235:genetics* / Q000401:mortality