[Correlation of proliferation index with submucosal invasion of hypopharyngeal cancer].
Proliferation index of biopsied specimens from 11 cases of hypopharyngeal carcinoma was studied immunohistochemically using anti-BrDU monoclonal antibody. S-phase cell labelling index (SLI) was measured and compared with the extent of submucosal invasion that was evaluated histologically in each extirpated specimen by means of continuous large section technique. Conclusions were as follows: 1. The largest SLI was obtained in a moderately differentiated carcinoma, and calculated up to 56, while the smallest was encountered in a well differentiated carcinoma as 18. Mean value in these 11 cases was 35. 2. It seemed likely that moderately or poorly differentiated carcinomas show larger SLI, but its statistical significance could not be delineated in these materials. 3. Submucosal invasion was much longer in the oral direction than in the anal. The longest invasion was observed in a case that showed the largest SLI, and measured up to 22 mm. The shortest invasion, on the contrary, was seen in a case with the smallest SLI, and was only 9 mm. Mean value in these 11 cases was 14.4 mm. 4. SLI correlates well in every case to the extent of submucosal invasion toward the oropharynx. 5. SLI evaluated preoperatively in biopsied specimen may help to indicate an ample safety margin at the surgery.
Murakami
Y
Y
Department of Otolaryngology, Kyoto Prefectural University of Medicine.
Yanuda
N
N
Murakami
M
M
Ohtsuki
T
T
Ohmori
A
A
Saito
Y
Y
Gotoh
T
T
Nin
F
F
Nakai
S
S
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology*; D007399:Interphase; D009092:Mucous Membrane / Q000473:pathology; D009361:Neoplasm Invasiveness; D010610:Pharyngeal Neoplasms / Q000473:pathology*