Germinal cell ectopism in the strepsirhine prosimian Galago crassicaudatus crassicaudatus.
The presence of germinal cells outside of the embryonal and fetal gonads of the strepsirhine prosimian Galago crassicaudatus crassicaudatus is described. Forty-three embryos and fetuses from day 26 or 27 of gestational age to near term were studied: more than 90% possessed germinal cells in ectopic sites situated either far from (extragonadal ectopism) or close to the gonads (perigonadal ectopism). The first sites were the walls of the aorta and mesenteric artery, the stroma between the aorta and the cardinal vein, and the retroperitoneal neuroganglia. The second were the mesenchyme dorsal to the gonads and around the vestigia of the mesonephric glomeruli and tubules, and the rete ovarii and testis. The ectopic cells were generally present in conscpicuous numbers, in some animals being more numerous than in the gonads. Those situated far from the gonads underwent degeneration and decreased significantly in numbers during post-embryonal stages of development, while the others remained numerous and functionally active up to near term. While the differentiation of the extragonadal germinal cells after day 60 of gestational age could not be studied due to technical difficulties, the XX and XY cells in perigonadal sites appeared to follow patterns of differentiation identical to those of their entopic counterparts.
Yoshinaga
K
K
Department of Pathology, Harbor-UCLA Medical Center, Torrance 90509.
Hess
D L
DL
Hendrickx
A G
AG
Zamboni
L
L
D000818:Animals; D001011:Aorta / Q000166:cytology; D005260:Female; D005701:Galago / Q000033:anatomy & histology / Q000196:embryology*; D005724:Ganglia / Q000166:cytology; D005854:Germ Cells / Q000166:cytology*; D005865:Gestational Age; D006066:Gonads / Q000033:anatomy & histology / Q000196:embryology*; D007668:Kidney / Q000196:embryology; D008297:Male; D008854:Microscopy, Electron; D012733:Sex Differentiation