In vitro cyto- and genotoxicity of organomercurials to cells in culture.
The sequence of cytotoxic effects for a series of mercury compounds to the BG/F epithelioid cells derived from fin tissue of bluegill sunfish was phenyl mercuric chloride greater than methyl mercuric chloride greater than ethyl mercuric chloride much greater than mercuric chloride. This sequence of in vitro cytotoxicity was similar to that observed in a 48-h LC50 in vivo acute toxicity assay with rainbow trout. Using induction of micronuclei as an indicator of genetic damage, the organomercurials, but not mercuric chloride, were noted to be clastogenic to the BG/F cells.
Babich
H
H
Laboratory Animal Research Center, Rockefeller University, New York, NY 10021.
Goldstein
S H
SH
Borenfreund
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E
D000818:Animals; D001711:Biotransformation; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D005399:Fishes; D005880:Gills; D015162:Micronucleus Tests; D009153:Mutagens / Q000493:pharmacokinetics; D009941:Organomercury Compounds / Q000493:pharmacokinetics / Q000633:toxicity*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
D009153:Mutagens; D009941:Organomercury Compounds; D014873:Water Pollutants; D014874:Water Pollutants, Chemical