Pregnancy increases cardiovascular toxicity to cocaine.
The effects of intravenous cocaine on heart rate and blood pressure were studied in pregnant and oophorectomized nonpregnant ewes. In response to intravenous cocaine doses of 1.0 and 2.0 mg/kg, both pregnant and nonpregnant ewes demonstrated dose-dependent increases in systolic, diastolic, mean arterial, and pulse pressures with return to baseline by 30 to 60 minutes after cocaine administration. However, at both doses (1.0 and 2.0 mg/kg) pregnant ewes demonstrated greater increases in mean arterial pressure (+29.6%, +48.7%) than nonpregnant ewes (+15.6%, +27.7%) during the first 5 minutes after cocaine administration. Thereafter the responses were similar. Thus pregnancy increases the cardiovascular toxicity to cocaine.
Woods
J R
JR
Department of Obstetrics-Gynecology, Strong Memorial Hospital, School of Medicine and Dentistry, University of Rochester, NY 14642.
Plessinger
M A
MA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D003042:Cocaine / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D012756:Sheep
D011941:Receptors, Adrenergic; D011374:Progesterone; D003042:Cocaine