Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis.
This case describes the clinical, biochemical and immunological features associated with relapse of thyrotoxicosis during pregnancy in a patient who had recently undergone a subtotal thyroidectomy for Graves' disease. The baby, shortly after birth, showed clinical and biochemical features of thyrotoxicosis which responded to carbimazole therapy. Thyrotropin receptor antibodies and thyroid stimulating antibodies were present in the blood of the mother and baby. The clinical course of the neonatal thyrotoxicosis correlated with the TSH receptor antibody levels.
Wilson
R
R
University Department of Medicine, Royal Infirmary, Glasgow.
Fraser
W D
WD
Gray
C E
CE
Alroomi
L G
LG
Thomson
J A
JA
D000328:Adult; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D002231:Carbimazole / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000276:immunology*; D011989:Receptors, Thyrotropin / Q000276:immunology*; D012008:Recurrence; D013960:Thyroid Function Tests; D013971:Thyrotoxicosis / Q000151:congenital / Q000188:drug therapy / Q000276:immunology*
D000906:Antibodies; D011989:Receptors, Thyrotropin; D002231:Carbimazole