Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes.
A single intraperitoneal injection of pregnant mice with a monovalent Formalin-inactivated influenza A virus vaccine protected their offspring against a lethal challenge dose of the same influenza A virus H3N2, H2N2, and H1N1 subtypes, as well as against challenge with the other two subtypes. Degree of protection was vaccine dose related. Cross-fostering of neonates indicated that protection was conferred by breast milk antibodies. Serum virus-specific neutralizing antibodies in the mothers and neonates correlated with resistance to vaccine virus, but were detected against other subtypes only in a complement enhancement test or when high doses of vaccine were given.
Mbawuike
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Influenza Research Center, Baylor College of Medicine, Houston, Texas 77030.
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D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D003429:Cross Reactions; D005260:Female; D007112:Immunity, Maternally-Acquired; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D013045:Species Specificity; D014611:Vaccination; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated