title: Alkaline phosphatase and phosphoamino acid phosphatases in normal and cancerous tissues of the human larynx.
abstract: The activities of alkaline phosphatase and phosphoamino acid phosphatases were measured in normal and cancerous regions of the human larynx. For each larynx, alkaline phosphatase and phosphotyrosine phosphatase activities were higher in the tumor than in the corresponding normal tissue. Phosphothreonine and phosphoserine phosphatase activities were relatively low and there were no consistent trends. The increased alkaline phosphatase activity in the tumors supports histological observations that ossification of cartilage seems to occur at the site of invasion; the phosphatase acting on phosphotyrosine could serve as a regulator of cell differentiation during tumorigenesis.
authors.affiliation: Department of Medical Biochemistry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: K D
authors.initials: KD
authors.lastname: Hammond
authors.forename: E
authors.initials: E
authors.lastname: Mohamed
authors.forename: R T
authors.initials: RT
authors.lastname: Gregor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology*; D007830:Larynx / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D000469:Alkaline Phosphatase