The effect on uteroplacental blood flow of epidural anaesthesia containing adrenaline for caesarean section.
The effect on uteroplacental blood flow of an epidural anaesthesia containing adrenaline for caesarean section was investigated in ten healthy women using dynamic placental scintigraphy with indium-113m and a computer-linked gamma camera. The epidural anaesthesia was performed with 18-22 ml bupivacaine 5 mg/ml with adrenaline 2.5 micrograms/ml followed by an i.v. balanced electrolyte infusion of 10 ml/kg b.w. A significant median decrease in the total maternal placental blood flow of 34% was found (P less than 0.01). There was also a significant decrease in maternal mean blood pressure of 3 mmHg (0.4 kPa) (P less than 0.05) and a significant negative correlation between the change in maternal blood pressure and the change in uteroplacental blood flow (r = -0.69, P less than 0.05).
Skjöldebrand
A
A
Department of Anaesthesiology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Eklund
J
J
Lunell
N O
NO
Nylund
L
L
Sarby
B
B
Thornström
S
S
D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007204:Indium; D007205:Indium Radioisotopes; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011877:Radionuclide Imaging; D014599:Uterus / Q000098:blood supply*
D007205:Indium Radioisotopes; D007204:Indium; C020758:indium trichloride; D004837:Epinephrine