Hematological abnormalities in hemophilic patients with human immunodeficiency virus infection.
Hematological abnormalities are common in patients with AIDS or AIDS-related complex. We studied cytological characteristics in peripheral blood and bone marrow samples of 33 hemophilic patients with HIV Infection and in six HIV negatives. The HIV-positive patients presented leukopenia (60.6%), thrombocytopenia (69.9%), and anemia (57.5%). Bone marrow showed abnormalities of maturation in one or more cell lines similar to those described in other HIV-infected groups of patients. These findings were more prominent in megakaryocytes and granulocytic series. Lymphocytosis, plasmocytosis, and increased hemophagocytosis were also common. These alterations do not appear in HIV-negative patients and seem related to a direct effect of HIV on bone marrow cells or to alterations in T-cell regulatory functions.
Bello
J L
JL
Hospital La Paz, Servicio de Hematologia, Madrid, Spain.
Burgaleta
C
C
Magallon
M
M
Herruzo
R
R
Villar
J M
JM
D000386:AIDS-Related Complex / Q000097:blood / Q000150:complications* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D004920:Erythropoiesis; D006679:HIV Seropositivity / Q000097:blood; D006467:Hemophilia A / Q000097:blood* / Q000473:pathology; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged