title: Quinine hepatotoxicity. An underrecognized or rare phenomenon?
abstract: Quinine-induced hepatic injury has been reported very rarely. We report a case involving a patient with an apparent hypersensitivity to quinine, manifested by a clinical syndrome mimicking a viral illness and a mixed hepatocellular-cholestatic liver injury pattern. We briefly review the unusual literature on this topic, which features many cases of hypersensitivity to the optical isomer of quinine, quinidine; yet, to our knowledge, there has only been one prior report of quinine hepatotoxicity.
authors.affiliation: Department of Medicine, Cleveland Metropolitan General Hospital, Case Western Reserve University, Ohio.
authors.forename: R C
authors.initials: RC
authors.lastname: Punukollu
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: K D
authors.initials: KD
authors.lastname: Mullen
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004796:Clinical Enzyme Tests; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D011803:Quinine / Q000009:adverse effects*
chemical_list: D011803:Quinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase