In vivo studies of lipid metabolism in lean and pre-obese swine.
Selection for high and low backfat in swine has resulted in obese and lean strains of swine. Fetuses (110 days) from obese dams (HF fetuses) when compared to fetuses from lean dams (LF fetuses) have larger fat cells, higher rates of palmitate esterification in adipose tissue and much higher levels of adipose tissue lipoprotein lipase (LPL) activity. In the present study an exogenous lipid load was given to HF and LF fetuses; lipid uptake into adipose tissue and liver was quantified as was the clearance of lipid from the blood. Uptake of lipid by liver was significant and similar for HF and LF fetuses. However, adipose tissue from HF fetuses took up significantly more lipid than did adipose tissue from LF features. Likewise, lipid clearance was greater in HF fetuses than in LF fetuses. Therefore, the amount of LPL activity in fetal adipose tissue is indicative of the functional capacity of the adipocytes to take up lipid and remove it from the blood.
Trusty
C D
CD
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Hausman
G J
GJ
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism; D050356:Lipid Metabolism; D009765:Obesity / Q000235:genetics*; D011247:Pregnancy; D013552:Swine / Q000378:metabolism*