[A case of systemic lupus erythematosus showing abnormal lipoproteins due to accompanied drug induced hepatitis].
We describe here a 28-years-male with AIHA and SLE who had lipid and lipoprotein abnormalities during cholestasis induced by PGE1 administration. High free cholesterol level, 792 mg/dl was found in his serum, and markedly elevated, phospholipid level 1,614 mg/dl. But, LCAT activity was within normal range in this case. An agarose gel electrophoresis of lipoproteins showed abnormal bands which were located in slow alpha 2, pre beta and slow beta, and between beta and origin point. Moreover, it was detected formation of Lp-X from serum of the patient. Serum levels of apoprotein B, C-II, C-III, and E were higher, while apoprotein A-I, A-II were very lower than reference value. From these results, it was suspected that the patient might occur transient abnormal lipid metabolism according to the drug induced hepatic injury.
Miura
M
M
Central Clinical Laboratories, Tokyo Metropolitan Police Hospital.
Kidokoro
H
H
Kojima
E
E
Hirano
T
T
Matsuzaki
H
H
Shimizu
T
T
Uto
H
H
Hirano
M
M
Oka
H
H
D000328:Adult; D000527:Alprostadil / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000209:etiology; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy; D008297:Male
D008074:Lipoproteins; D000527:Alprostadil