title: Bone surface structure in osteopetrotic grey lethal (gl/gl) and microphthalmic (mi/mi) mutant mice as revealed by scanning electron microscopy.
abstract: The surface structure of bone from two genetically distinct osteopetrotic strains of mice, grey lethal (gl) and microphthalmic (mi) has been examined by scanning electron microscopy. Although both conditions produce a classical osteopetrotic phenotype the means by which this is achieved is quite different. gl mice appear to retain woven bone and show no evidence of resorption: mi mice show evidence of imperfect remodelling. These results are in accordance with what is already known of osteoclast structure and function in these mutations.
authors.affiliation: Department of Anatomy, University of Leeds, W. Yorks, England.
authors.forename: D R
authors.initials: DR
authors.lastname: Johnson
authors.forename: P
authors.initials: P
authors.lastname: O'Higgins
mesh_terms: D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000648:ultrastructure*; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology*; D008850:Microphthalmos / Q000235:genetics; D008855:Microscopy, Electron, Scanning; D010022:Osteopetrosis / Q000145:classification / Q000235:genetics / Q000473:pathology*; D013499:Surface Properties