[The effective dosage as the stimulating exposure in fractionated gamma irradiation].
The study of early neurological disturbances (END) in rats after fractionated gamma irradiation with doses of 37.5-225 Gy at dose rate of 30.11 Gy/min has demonstrated that the initial response of animals to pulse ionizing radiation is a function of the electric charge induced by ionizing radiation. A change in the probability of occurrence of each of the END symptoms, with the increased intervals between exposures, is merely an indirect indication of the eliminating mechanisms and is intricately connected with the irritating charge value. The period of dose half-elimination in 16 min. The threshold effective dose rate leading to END is of the order of 2.12 Gy/min. The proposed empiric relationships permit to correlate the probability of END symptom occurrence with the continuous quantitative parameter of fractionated irradiation, that is, with an effective dose as an analogue of the irritating effect.
Karpov
V N
VN
Ushakov
I B
IB
Davydov
B I
BI
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005720:Gamma Rays; D000860:Hypoxia / Q000503:physiopathology; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D009584:Nitrogen / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage; D011336:Probability; D011833:Radiation Injuries, Experimental / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D012062:Relative Biological Effectiveness; D013997:Time Factors
C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
Effektivnaia doza kak razdrazhaiushchee vozdeĭstvie pri fraktsionirovannom gamma-obluchenii.