Spontaneous regression of neuroblastoma: an experimental approach.
The cytolytic activity of normal pregnancy serum was first studied on murine cancer cells and shown to be the result of a natural IgM antibody that binds to cell surfaces and activates complement. Both the classical and alternative pathways of complement are involved. It was then shown that certain human neuroblastoma cell lines, to the exclusion of other human cancers, react to the same system. It is proposed that this system may play a role in the cytolytic form of spontaneous regression of neuroblastoma.
Bolande
R P
RP
Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
D000818:Animals; D002470:Cell Survival; D003167:Complement Activation; D003165:Complement System Proteins / Q000502:physiology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D009365:Neoplasm Regression, Spontaneous; D009447:Neuroblastoma / Q000473:pathology; D011247:Pregnancy / Q000097:blood; D014407:Tumor Cells, Cultured
D007075:Immunoglobulin M; D003165:Complement System Proteins