title: Synthesis of 17 beta-(3'-thiophenyl)-5 beta-androstane-3 beta,14 beta-diol 3-D-glucopyranoside, an anti-inotropic cardiac glucoside.
abstract: In a continuing effort to synthesize cardiac glucoside analogs with modified 17 beta-functional groups for pharmacologic testing, we used 3 beta-benzyloxy-5 beta-androst-15-en-17-one as an efficient intermediate. This report describes a preparation of 17 beta-(3'-thiophenyl)-5 beta-androstane-3 beta,14 beta-diol 3-D-glucopyranoside.
authors.affiliation: Natural Products Research Center, University of New Brunswick, Fredericton, Canada.
authors.forename: U K
authors.initials: UK
authors.lastname: Pati
authors.forename: K
authors.initials: K
authors.lastname: Wiesner
mesh_terms: D000732:Androstanols; D002301:Cardiac Glycosides / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D009200:Myocardial Contraction / Q000187:drug effects; D013268:Stimulation, Chemical
chemical_list: D000732:Androstanols; D002301:Cardiac Glycosides; C063631:17-(3'-thiophenyl)androstane-3,14-diol 3-glucopyranoside