Comparison of effectiveness of 3 dithiocarbamates on excretion and distribution of cadmium in rats and mice.
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-methylbenzyl-D-glucamine dithiocarbamate (MBGD), and sodium N-p-isopropylbenzyl-D-glucamine dithiocarbamate (PBGD), which were recently synthesized, were evaluated for their efficacy in the distribution and excretion of cadmium in rats and mice exposed to cadmium. Rats and mice were injected i.p. with 109CdCl2 (1 mg Cd/kg and 2 microCi 109Cd/one animal) and 3 days later, they were treated with the dithiocarbamates (400 mumol/kg) every other day for 2 weeks. These dithiocarbamates were effective in removing cadmium from the body without increasing the cadmium content in the kidney. After treatment with BGD, MBGD, and PBGD, cadmium was excreted mainly in the feces and the effect of MBGD and PBGD on the fecal excretion of cadmium was much larger than that of BGD. The treatment with these dithiocarbamates did not cause the redistribution of cadmium to brain, testes, and heart in rats and mice. The treatment of mice with PBGD decreased the concentrations of essential metals in liver, kidney, and brain. The extent of acute toxicity of the dithiocarbamates in mice was in the order PBGD greater than MBGD greater than BGD.
Kiyozumi
M
M
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Nouchi
T
T
Honda
T
T
Kojima
S
S
Tsuruoka
M
M
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics*; D002614:Chelating Agents / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution / Q000187:drug effects
D002614:Chelating Agents; D013859:Thiocarbamates; D002104:Cadmium; D013012:Sorbitol; C048763:N-benzylglucamine dithiocarbamate