[The effect of mexamine on liver mitochondrial function in rats in vivo and in vitro from the aspect of the mechanisms of the pharmacological and radioprotective action of the protector].
The polarographic study of the functional status (FS) of rat liver mitochondria subjected to the effect of mexamine in vivo and in vitro and the hypoxic hypoxia in vivo has revealed various FS changes displaying disconnecting and rotenone-like effects and posthypoxic activation. With a mexamine dose of 50 mg/kg in vivo the direct effect of the protector contributes considerably to the mitochondrial FS. Within a wide range of mexamine doses no relationship was found between the pattern of the mitochondrial FS change in the liver and the protective effect with respect to bone marrow.
Rozhdestvenskiĭ
L M
LM
Kormer
Z S
ZS
Sushko
L V
LV
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D011837:Radiation-Protective Agents; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors
D011837:Radiation-Protective Agents; D012701:Serotonin; D008735:5-Methoxytryptamine
Vliianie meksamina na funktsional'noe sostoianie mitokhondriĭ pecheni krys in vivo i in vitro v aspekte mekhanizmov farmakologicheskogo i radiozashchitnogo deĭstviia protektora.