title: B-vitamins enhance afferent inhibitory controls of nociceptive neurons in the rat spinal cord.
abstract: Afferent inhibition of spinal dorsal horn neuronal responses to noxious skin heating was induced by transcutaneous electrical nerve stimulation in pentobarbital-anesthetized rats. Pretreatment with B vitamins significantly enhanced this afferent inhibition, possibly due to an increase in the synthesis rate of inhibitory neurotransmitters in central neurones.
authors.affiliation: II. Physiologisches Institut der Universität Heidelberg.
authors.forename: Q G
authors.initials: QG
authors.lastname: Fu
authors.forename: J
authors.initials: J
authors.lastname: Sandkühler
authors.forename: M
authors.initials: M
authors.lastname: Zimmermann
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects*; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013697:Thermosensing / Q000187:drug effects; D013979:Tibial Nerve / Q000187:drug effects; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D014803:Vitamin B Complex