Naphthalene derivatives that selectively inhibit an antigen-specific IgE response in murine lymphocytes.
When the spleen cells from BALB/c mice that had been immunized twice with TNP-KLH were cultured with the same antigen, the synthesis of anti-TNP IgE as well as anti-TNP IgG was induced. We found that the addition of a naphthalene derivative, (E)-N-(2-methoxy-carbonylphenyl)-8-(2-naphthyl)-5,6-trans-5,6-meth ano-7- octenamide (TEI-1338) or methyl-6,7-dihydroxy-2-naphthylthioacetate (TEI-3332) to this lymphocyte culture system resulted in a marked suppression of anti-TNP IgE response without affecting the corresponding IgG production. These compounds are expected to be a prototype for the drug that can be used for the treatment of IgE-mediated allergic diseases.
Ohmori
H
H
Department of Biotechnology, Faculty of Engineering, Okayama University, Japan.
Hazato
A
A
Kato
Y
Y
Kurozumi
S
S
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006241:Haptens; D006433:Hemocyanins / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009281:Naphthalenes / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D006241:Haptens; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D009281:Naphthalenes; C054401:trinitrophenyl keyhole limpet hemocyanin; D007073:Immunoglobulin E; D006433:Hemocyanins