Antiarrhythmic properties of amitriptyline.
Clinical studies and case reports have shown that nortriptyline and imipramine exert type 1 antiarrhythmic properties when plasma concentrations are therapeutic, indicating that clinical reservation against their use in cardiac patients may be overstated. The clinical cardiac effects of amitriptyline have not been extensively reported. The case I have reported details the electrophysiologic record of the beneficial and safe use of amitriptyline in a patient with severe cardiac arrhythmias and organic affective disorder.
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Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond.
D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010244:Bulbar Palsy, Progressive / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications; D004562:Electrocardiography; D005260:Female; D006801:Humans; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D000639:Amitriptyline