title: Platelet and plasma catecholamines in relation to plasma minerals and parathyroid hormone following acute myocardial infarction.
abstract: Epinephrine has been shown to lower the plasma concentrations of several minerals and elevate those of parathyroid hormone (PTH). In order to evaluate the possible clinical importance of such experimental observations, 34 patients with acute myocardial infarction (AMI) were studied with daily determinations of plasma catecholamines, minerals, and PTH during the first week after AMI and at follow-up one month later. In addition, platelet catecholamines were determined as they fluctuate more slowly than plasma catecholamines. After infarction initial platelet epinephrine and norepinephrine levels were higher (p less than 0.05 for both) in nonsurvivors than survivors during a one year follow-up. Results suggested that activation of the sympathoadrenal system influences calcium homeostasis following AMI, but that the impact of sympathoadrenal activation on mineral metabolism is of minor clinical significance in the average AMI patient. High platelet catecholamine levels may predict a poor outcome after AMI.
authors.affiliation: Department of Internal Medicine, University Hospital, Uppsala, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Joborn
authors.forename: P
authors.initials: P
authors.lastname: Hjemdahl
authors.forename: P T
authors.initials: PT
authors.lastname: Larsson
authors.forename: H
authors.initials: H
authors.lastname: Lithell
authors.forename: L
authors.initials: L
authors.lastname: Lundin
authors.forename: L
authors.initials: L
authors.lastname: Wide
authors.forename: S
authors.initials: S
authors.lastname: Ljunghall
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000097:blood*; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood*; D009638:Norepinephrine / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D013564:Sympathetic Nervous System / Q000502:physiology; D013997:Time Factors
chemical_list: D005230:Fatty Acids, Nonesterified; D008903:Minerals; D010281:Parathyroid Hormone; D009638:Norepinephrine; D004837:Epinephrine