Evidence for a single butyrylcholinesterase gene in individuals carrying the C5 plasma cholinesterase variant (CHE2).
DNA of 3 unrelated individuals carrying the human plasma butyrylcholinesterase C5 variant (CHE2) was isolated from white blood cells. Southern blot patterns of DNA restriction fragments probed with each of the 4 butyrylcholinesterase exons provided evidence that the production of C5 is not directed by a second butyrylcholinesterase gene. This finding supports the suggestion that the C5 variant is a hybrid enzyme resulting from the association of butyrylcholinesterase subunits with a non-cholinesterase protein.
Masson
P
P
Centre de Recherches du Service de Santé des Armées, Unité de Biochimie, La Tronche, France.
Chatonnet
A
A
Lockridge
O
O
D002091:Butyrylcholinesterase / Q000235:genetics*; D002802:Cholinesterases / Q000235:genetics*; D004247:DNA / Q000032:analysis; D006801:Humans
D004247:DNA; D002091:Butyrylcholinesterase; D002802:Cholinesterases