Hypertension as a risk factor for sudden cardiac death and nonfatal myocardial infarction. Working Group of CNR Study OD1.
To evaluate long-term prognosis during medical treatment of hypertension associated with angina pectoris, a total of 1083 patients with angiographically-documented coronary artery disease were followed for a mean of 66 months. At the end of the study, follow-up was complete in 98% of all patients. Of the 1083 patients, 132 (12%) had hypertension and 951 (88%) were not hypertensive. During the follow-up period, there was a total of 15 deaths (11.3%) among the hypertensive population (vs. 61 or 6.4% in the nonhypertensives) as well as a higher incidence of nonfatal myocardial infarction (9.0% in the hypertensives vs. 3.7% in the nonhypertensives) (Figure 2). Six-year cumulative survival was 84% in the hypertensive patients as compared to 92% in the nonhypertensives. Among risk factors, historical data, clinical and catheterization findings, the only noninvasively-obtainable independent predictor of prognosis using multivariate analysis was hypertension (Table 3).
Brunelli
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C
Department of Cardiology, University of Genova, Italy.
Cristofani
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R
L'Abbate
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A
D000206:Actuarial Analysis; D002423:Cause of Death; D003645:Death, Sudden / Q000453:epidemiology / Q000209:etiology*; D004562:Electrocardiography; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000401:mortality; D007558:Italy; D009203:Myocardial Infarction / Q000209:etiology* / Q000401:mortality; D012307:Risk Factors