title: Effect of the mode of croscarmellose sodium incorporation on tablet dissolution and friability.
abstract: A computer-optimized experimental design was used to study the effect of incorporating a "super disintegrant", croscarmellose sodium, intragranularly, extragranularly, or distributed equally between the two phases of a tablet in which a poorly soluble drug constituted at least 92.5% of the formulation. The results were analyzed by means of a general quadratic response surface model and suggest that tablets with the same total concentration of super disintegrant dissolve at a faster rate when the super disintegrant is included intragranularly. Tablet friability was not affected by the method of super disintegrant incorporation.
authors.affiliation: Institute of Pharmaceutical Sciences, Syntex Inc., Palo Alto, CA 94304.
authors.forename: M S
authors.initials: MS
authors.lastname: Gordon
authors.forename: B
authors.initials: B
authors.lastname: Chatterjee
authors.forename: Z T
authors.initials: ZT
authors.lastname: Chowhan
mesh_terms: D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients; D006244:Hardness; D008747:Methylcellulose / Q000031:analogs & derivatives; D012995:Solubility; D013607:Tablets
chemical_list: D005079:Excipients; D013607:Tablets; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium