[Biochemical analysis of bone and mineral metabolism in liver cirrhosis].
We investigated the disorder of bone and mineral metabolism in 29 patients with liver cirrhosis who were classified into two subgroups with (group 1, n = 13) or without (group 2, n = 13) osteopenia according to the method of Jikei. Serum levels of osteocalcin level, bone-type alkaline phosphatase activity and calcium concentration in serum and urine in these patients and 25 normal control subjects were determined. Serum osteocalcin level and bone-type alkaline phosphatase activity were elevated in group 1 compared with those in group 2 and normal control subjects. Serum and urine calcium levels in group 1 were similar to those in group 2. However calcium-creatinine ratio in urine was higher in group 1 than in group 2. These present observations indicate that osteopenia in patients with liver cirrhosis is due to high turnover of bone metabolism.
Kanda
T
T
Department of Internal Medicine, Osaka Prefectural Hospital.
Otsuki
M
M
Nishikawa
Y
Y
Okabayashi
K
K
Yoshida
T
T
Matsumura
T
T
Suematsu
T
T
Uematsu
I
I
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood
D008903:Minerals; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002118:Calcium