Accelerated thrombolysis and reperfusion in a canine model of myocardial infarction by liposomal encapsulation of streptokinase.
The aim of thrombolytic therapy for acute myocardial infarction with plasminogen activators such as streptokinase is to lyse the coronary thrombus and reestablish blood flow as quickly as possible so that heart tissue loss is minimized and mortality rates are improved. Streptokinase has been encapsulated in large unilamellar phospholipid vesicles and tested in an animal model of acute myocardial infarction. The time required to restore vessel patency has been reduced more than 50% when compared with findings for free streptokinase. The total dosage of streptokinase required was lower, and smaller remnant thrombi were observed with the encapsulated agent. Results from this initial unoptimized study may have significant implications for further reduction in mortality from heart attacks by therapy with plasminogen activators.
Nguyen
P D
PD
Department of Chemical Engineering, University of Oklahoma, Norman.
O'Rear
E A
EA
Johnson
A E
AE
Patterson
E
E
Whitsett
T L
TL
Bhakta
R
R
D000818:Animals; D004285:Dogs; D004337:Drug Carriers; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008247:Lysosomes; D009203:Myocardial Infarction / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D013300:Streptokinase / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D004337:Drug Carriers; D005343:Fibrinolytic Agents; D013300:Streptokinase