title: Changes in endocochlear potential during anoxia after intense noise exposure.
abstract: Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succino-dehydrogenase (SDH) activity and morphologic changes in hair cells were also evaluated in surface preparations of the hair cells. It was found that changes in EPs correlated with the duration of noise exposure. The longer the noise exposure, the greater the decrease in EPs. EPs could recover in one week post-exposure, in roughly the same time needed for recovery of SDH activity in hair cells. Noise exposure also resulted in some changes in EP dynamic behaviour during and after reversible anoxia, but did not cause any significant change in maximal negative EP. The mechanisms underlying these results are discussed.
authors.affiliation: Fundamental Medical Department, Nanjing Railway Medical College, China.
authors.forename: J A
authors.initials: JA
authors.lastname: Wang
authors.forename: W J
authors.initials: WJ
authors.lastname: Dong
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism / Q000503:physiopathology*; D003056:Cochlear Nerve / Q000378:metabolism / Q000503:physiopathology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000473:pathology; D000860:Hypoxia / Q000503:physiopathology*; D008564:Membrane Potentials; D009622:Noise / Q000009:adverse effects*; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D013385:Succinate Dehydrogenase