The nucleotide and deduced amino acid sequences of a cDNA encoding a new species of pregnancy-specific beta 1-glycoprotein (PS beta G).
We screened a cDNA library of a human placenta with cDNA for nonspecific cross-reacting antigen, a member of the carcinoembryonic antigen gene family. One of the positive clones, PS34, was found to encode a 426 amino acid protein belonging to pregnancy-specific beta 1-glycoprotein (PS beta G). The mature PS34 protein consisted of domains, N, A1, A2, B2 and C. The domain-N of PS34 showed sequence similarities of 79.8-83.5% to those of the PS beta G members so far reported, indicating PS34 is a new member of PS beta G and also of the carcinoembryonic antigen gene family.
Arakawa
F
F
First Department of Biochemistry, School of Medicine, Fukuoka University, Japan.
Kuroki
M
M
Misumi
Y
Y
Matsuo
Y
Y
Matsuoka
Y
Y
D000595:Amino Acid Sequence; D001483:Base Sequence; D002272:Carcinoembryonic Antigen / Q000235:genetics; D004247:DNA / Q000235:genetics*; D005260:Female; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000235:genetics*
D002272:Carcinoembryonic Antigen; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D004247:DNA