[Treatment of radiogenic colitis with a rectal foam containing cortisol. Clinical and pharmacologic data].
20 patients with highly dosed irradiation of the small pelvis had been treated with Colifoam (hydrocortisone) in order to prove the therapeutic effect of radiation-induced proctitis. Over a period of three to six weeks starting in the third week of irradiation all patients received one applicator filling of rectal foam after bowel movement daily. The findings were verified by proctoscopy, histology and subjective personal well being. In ten patients we determined the daily cortisol profiles. Six months post irradiation ten patients underwent barium enema of the colon. During therapy no major complaints were recorded. The proctoscopic findings showed little changes concerning the submucous vascular walls. In none of the patients any kind of late lesion could be observed. The daily cortisol profile did not show any aberration of the physiological patterns. In conclusion the local therapy of Colifoam can be considered an additional treatment of radiation-induced colitis (proctitis).
Szepesi
S
S
Zentrum der Radiologie, Pharmakologisches Institut der Ruprecht-Karls-Universität Heidelberg.
Jacobi
V
V
Vecsei
P
P
Böttcher
H D
HD
D000008:Abdominal Neoplasms / Q000150:complications / Q000532:radiotherapy; D000285:Administration, Rectal; D000328:Adult; D003092:Colitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000150:complications / Q000532:radiotherapy; D011349:Proctitis / Q000188:drug therapy / Q000209:etiology; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D011879:Radiotherapy Dosage; D013997:Time Factors
C021650:hydrocortisone acetate; D006854:Hydrocortisone
Die Therapie der radiogenen Kolitis mit einem cortisolhaltigen Rektalschaum. Klinische und pharmakologische Daten.