Magnetic starch microspheres, efficacy and elimination. A new organ-specific contrast agent for magnetic resonance imaging.
A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization of the substance. MSM doses in a range of 0.3-1.5 mg Fe/kg caused a 50% alteration in sensitive contrast parameters (ED50 doses) of liver and spleen. The contrast effect of MSM in liver and spleen was halved within 2 to 5 days. The approximated lethal MSM dose in mice was 150-200 mg Fe/kg. MSM is a tissue-specific MR contrast substance with high efficacy, rapid bioelimination, and low acute toxicity.
Fahlvik
A K
AK
Department of Pharmacology, University of Oslo, Norway.
Holtz
E
E
Leander
P
P
Schrøder
U
U
Klaveness
J
J
D000818:Animals; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D012996:Solutions; D013213:Starch / Q000008:administration & dosage
D003287:Contrast Media; D005290:Ferric Compounds; D012996:Solutions; C000499:ferric oxide; D013213:Starch