Terminal deletions of the long arm of chromosome 7: five new cases.
Twenty-two cases of terminal deletions of the long arm of chromosome 7 have been reported. We present 5 new cases, 3 of which were ascertained due to fetal holoprosencephaly, one due to anencephaly, and one due to multiple structural defects in a 15-year-old boy. The presence of holoprosencephaly in 3 of the 5 cases reported herein and in 2 previously reported cases suggests that this manifestation may be commonly observed in individuals with deletion 7q.
Bogart
M H
MH
Department of Medicine, University of California, San Diego 92093.
Cunniff
C
C
Bradshaw
C
C
Jones
K L
KL
Jones
O W
OW
D000015:Abnormalities, Multiple / Q000196:embryology / Q000235:genetics*; D000293:Adolescent; D001921:Brain / Q000002:abnormalities; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011296:Prenatal Diagnosis