title: The variance of sample heterozygosity.
abstract: The variance of sample heterozygosity, averaged over several loci, is studied in a variety of situations. The variance depends on the sampling implicit in the mating system as well as on that explicit in the loci scored and individuals sampled. There are also effects of allelic distributions over loci and of linkage or linkage disequilibrium between pairs of loci. Results are obtained for populations in drift and mutation balance, for infinite populations undergoing mixed self and random mating, and for finite monoecious populations with or without selfing. For unlinked loci in drift/mutation balance, variances appear to be lessened more by increasing the number of loci scored than by increasing the number of individuals sampled. For infinite populations under the mixed self and random mating system, however, the reverse is true. Methods for estimating the variance of sample heterozygosity are discussed, with attention being paid to unbalanced data where not all loci are scored in all individuals.
authors.affiliation: Department of Statistics, North Carolina State University, Raleigh 27695-8203.
authors.forename: B S
authors.initials: BS
authors.lastname: Weir
authors.forename: J
authors.initials: J
authors.lastname: Reynolds
authors.forename: K G
authors.initials: KG
authors.lastname: Dodds
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D005787:Gene Frequency / Q000235:genetics; D005788:Gene Pool; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D012641:Selection, Genetic