Altromycins, novel pluramycin-like antibiotics. I. Taxonomy of the producing organism, fermentation and antibacterial activity.
The altromycins are novel anthraquinone-derived antibiotics related to the pluramycins. They are produced by an actinomycete, AB 1246E-26, which was isolated from a South African bushveld soil. The altromycins have Gram-positive antibacterial activity with MICs of 0.2 to 3.12 micrograms/ml against Streptococci and Staphylococci.
Jackson
M
M
Anti-infective Research Division, Abbott Laboratories, IL 60064.
Karwowski
J P
JP
Theriault
R J
RJ
Hardy
D J
DJ
Swanson
S J
SJ
Barlow
G J
GJ
Tillis
P M
PM
McAlpine
J B
JB
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005285:Fermentation; D012988:Soil Microbiology; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C063716:altromycin A; C063718:altromycin C; C063717:altromycin B; C063719:altromycin D