Mitochondrial encephalomyopathy (MELAS) with mental disorder. CT, MRI and SPECT findings.
A case of mitochondrial encephalomyopathy (MELAS) with mental disorder is reported. The SPECT study using 123I-iodoamphetamine (IMP) and MRI study revealed abnormality in the left parieto-occipital areas without abnormality in the brain CT or brain scintigram. These findings suggest a localized dysfunction of the brain capillary endothelium in association with the cerebral involvement of mitochondrial encephalomyopathy.
Suzuki
T
T
Department of Psychiatry, University of Tsukuba, Japan.
Koizumi
J
J
Shiraishi
H
H
Ishikawa
N
N
Ofuku
K
K
Sasaki
M
M
Hori
T
T
Ohkoshi
N
N
Anno
I
I
D000140:Acidosis, Lactic / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008931:Mitochondria, Muscle / Q000473:pathology*; D011877:Radionuclide Imaging; D013577:Syndrome; D014057:Tomography, X-Ray Computed