Evaluation of new test (Phadiatop) for the screening of respiratory allergic disorders in children.
The present study investigated the sensitivity, specificity, and predictive value of a new in vitro test, the Phadiatop, which detects the presence in serum of specific IgE to a balanced mixture of the most frequent inhalant allergens. Ninety-eight children (63 males, 35 females) 2-12 years old (median age = 6), suffering from rhinitis and/or conjunctivitis and/or asthma were studied. Our data show that Phadiatop has an 87% sensitivity, a 100% specificity, a 92% efficiency, a 100% positive predictive value, and an 86% negative predictive value. These results indicate that Phadiatop is very effective in diagnosing atopy (no false positive). However, a negative Phadiatop does not exclude the diagnosis of atopy.
Cantani
A
A
Department of Pediatrics, University of Roma La Sapienza, Italy.
Ferrara
M
M
Barbieri
C
C
Monteleone
A
A
Businco
L
L
D002648:Child; D002675:Child, Preschool; D003955:Diagnostic Tests, Routine / Q000379:methods / Q000592:standards*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D008297:Male; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*; D012882:Skin Tests