title: An autopsy case of peritoneal malignant mesothelioma in a radiation technologist.
abstract: A case of peritoneal malignant mesothelioma in a radiation technologist, who had worked in this field for 34 years, is reported. Histopathologically, a biopsy specimen from the retroperitoneal tumor revealed a biphasic type of malignant mesothelioma. Electron microscopy disclosed that the tumor cells contained prominent microvilli, basal laminae adjacent to the stroma, junctional complexes, desmosomes, tonofilaments, clusters of glycogen granules, well developed rough endoplasmic reticulum (RER), confronting cisternae showing direct continuity with the RER and membrane-bound granules suggestive of secretory activity. No increased amount of asbestos was detected in autopsied lung material or the peritoneal mesothelioma. The estimated cumulative dose of occupational irradiation was calculated to be about 40 to 50 rad at most. Irradiation was discussed in relation to the etiology of the peritoneal mesothelioma.
authors.affiliation: Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Horie
authors.forename: K
authors.initials: K
authors.lastname: Hiraoka
authors.forename: O
authors.initials: O
authors.lastname: Yamamoto
authors.forename: J
authors.initials: J
authors.lastname: Haratake
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Sugimoto
mesh_terms: D001344:Autopsy; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000648:ultrastructure; D009784:Occupational Diseases / Q000209:etiology / Q000473:pathology*; D010529:Peritoneal Cavity / Q000473:pathology / Q000528:radiation effects; D010534:Peritoneal Neoplasms / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure; D011832:Radiation Injuries