Intraoperative hemodynamics in liver transplantation comparing orthotopic with heterotopic transplantation in the pig.
The intraoperative hemodynamic changes and several graft function parameters were studied comparing orthotopic liver transplantation with auxiliary partial liver transplantation (APLT) in the pig. Thirty-one Yorkshire pigs (ca. 25 kg b.w.) were randomly allocated to OLT (n = 16) or APLT (n = 15). During the construction of portal anastomosis the median cardiac output dropped to 67% of the initial value in OLT and to 49% in APLT (P less than 0.02). Median duration of the portal flow interruption was shorter in APLT: 15 min versus 48 min in OLT (P less than 0.002). After unclamping of the aorta, the median systolic blood pressure dropped to 75 mmHg in OLT and to 90 mmHg in APLT (P less than 0.02). APLT is less time-consuming: median duration of transplantation was 128 min versus 165 min in OLT (P less than 0.002). SGOT levels were lower in APLT than in OLT (median SGOT on the first postoperative day 67 was IU/L versus 177 IU/L, P less than 0.002). It is concluded that APLT is a shorter procedure than OLT with a shorter portal flow interruption, being less offensive to the recipient.
Blankensteijn
J D
JD
Department of Surgery, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Groenland
T H
TH
Baumgartner
D
D
Vos
L P
LP
Kerkhofs
L G
LG
Terpstra
O T
OT
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002302:Cardiac Output; D005260:Female; D006439:Hemodynamics; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D011897:Random Allocation; D013552:Swine; D016042:Transplantation, Heterotopic / Q000401:mortality / Q000502:physiology*
D001219:Aspartate Aminotransferases