Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.
The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.
Treanor
J J
JJ
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Tierney
E L
EL
Zebedee
S L
SL
Lamb
R A
RA
Murphy
B R
BR
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D007116:Immunization, Passive; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology; D008168:Lung / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D014763:Viral Matrix Proteins / Q000276:immunology*; D014779:Virus Replication; D000086082:Viroporin Proteins
D000911:Antibodies, Monoclonal; D014763:Viral Matrix Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins