Studies on new dehydropeptidase inhibitors. III. Biological properties of WS1358A1.
WS1358A1, a novel inhibitor of renal dehydropeptidase (DHP), augmented the urinary recovery of a carbapenem antibiotic imipenem and improved its protective effect in experimental infections when simultaneously administered to mice with the antibiotic. WS1358A1 was a competitive DHP inhibitor with a Ki value of 1.6 x 10(-7) M.
Hashimoto
S
S
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Murai
H
H
Nitta
K
K
Fujie
A
A
Okuhara
M
M
Kohsaka
M
M
Imanaka
H
H
D000818:Animals; D004150:Dipeptidases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D005260:Female; D005977:Glutarates / Q000494:pharmacology* / Q000627:therapeutic use; D015378:Imipenem / Q000627:therapeutic use / Q000652:urine; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D051379:Mice; D008813:Mice, Inbred ICR; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013552:Swine
D005977:Glutarates; C063283:WS 1358A1; D015378:Imipenem; D004150:Dipeptidases; C038937:dipeptidase