title: [Endocavitary transcatheter electric fulguration as a therapeutic alternative in refractory ventricular tachycardia].
abstract: Three patients affected by dilated cardiomyopathy complicated by refractory ventricular tachycardia, with a high risk of sudden cardiac death, underwent transcatheter electric fulguration. The technique was applied transeptally, using the terminals of two catheter electrodes as cathode and anode. These were placed at the right and left ventricular apex, at septal level where the "critical" arrhythmia point had been identified by endocardial mapping. All patients had previously experienced more than one episode of cardiac arrest and had successfully taken several antiarrhythmic drugs. All patients presented variable morphology of ventricular tachycardia (whether spontaneous or induced). In all of them clinical tachycardia was considered as having a left bundle branch block morphology with an earlier activation at low septal level. After treatment, antiarrhythmic therapy (amiodarone 200 mg/day) was continued for all patients, although at a lower dose than before fulguration. One patient has been free from sustained ventricular tachycardia for more than two years after fulguration. In the other patients we observed an early and late arrhythmic recurrence (respectively within 1 and 8 months following fulguration) in spite of antiarrhythmic therapy. The second patient presented no further recurrence after permanent pacemaker implantation. The third patient showed an arrhythmic recurrence, with a different morphology from the previous one, concomitantly with a septic process. This technique does not appear dangerous and may be used, in highly specialized centres, on carefully selected patients as a therapeutic approach after pharmacological therapy and before automatic defibrillator implantation or surgical antiarrhythmic intervention.
authors.affiliation: Servizio di Elettrofisiologia ed Elettrostimolazione Cardiaca, Ospedale, San Camillo, Roma.
authors.forename: M
authors.initials: M
authors.lastname: Santini
authors.forename: G
authors.initials: G
authors.lastname: Ansalone
authors.forename: G
authors.initials: G
authors.lastname: Cacciatore
authors.forename: G
authors.initials: G
authors.lastname: Di Marcotullio
authors.forename: M
authors.initials: M
authors.lastname: Carelli
authors.forename: M
authors.initials: M
authors.lastname: Tubaro
authors.forename: G
authors.initials: G
authors.lastname: Alexidou
authors.forename: I
authors.initials: I
authors.lastname: Bisceglie
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000150:complications; D002404:Catheterization; D004598:Electrosurgery; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000601:surgery*; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D013610:Tachycardia / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D013997:Time Factors
chemical_list: D000638:Amiodarone
vernacular_title: La folgorazione elettrica endocavitaria transcatetere quale alternativa terapeutica della tachicardia ventricolare refrattaria.