Improvement in blood flow and diameter of the postanastomotic rat tail artery by topical application of lidocaine in varying concentrations.
Prolonged spasm in small vessels is a major problem after microsurgical procedures. Topical agents applied to resolve these spasms have been the subject of many experimental studies. In this model we studied the effectiveness of various concentrations of lidocaine in resolving microvascular spasms induced by anastomosing the ventral rat tail artery.
Beekman
W H
WH
Department of Plastic and Reconstructive Surgery, Academic Hospital Dijkzigt, Rotterdam, The Netherlands.
Dammeijer
P F
PF
Sluimers
J E
JE
Kort
W J
WJ
van der Meulen
J H
JH
D000287:Administration, Topical; D000714:Anastomosis, Surgical; D000818:Animals; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D011914:Rats, Inbred BN; D012039:Regional Blood Flow / Q000187:drug effects; D013623:Tail / Q000033:anatomy & histology / Q000098:blood supply* / Q000601:surgery; D014654:Vascular Patency / Q000187:drug effects*
D008012:Lidocaine