title: A new porous polyetherurethane wound covering.
abstract: A polyetherurethane (PEU) wound covering with non-interconnected micropores up to approximately 5 microns has been prepared by means of a phase inversion process. This highly elastic, very thin (15-20 microns), pliable wound covering showed good, immediate adherence to wet wound surfaces and high water vapor permeability, but was impermeable to bacteria. In guinea pigs epidermal wound healing of partial-thickness wounds under PEU wound coverings was accelerated compared with uncovered controls and an occlusive wound covering, OpSite. Water in liquid form or wound exudate could not leak through the PEU covering, but its high water vapor permeability induced concentration of the wound exudate into a jellylike clot layer, which apparently accelerated reepithelialization. The main conclusion from a clinical study on 20 donor sites was that the use of the PEU covering reduced pain, besides prevention of fluid retention. No differences in epithelialization were seen in comparison to tulle gras-treated wounds.
authors.affiliation: Department of Polymer Chemistry, University of Groningen, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Bruin
authors.forename: M F
authors.initials: MF
authors.lastname: Jonkman
authors.forename: H J
authors.initials: HJ
authors.lastname: Meijer
authors.forename: A J
authors.initials: AJ
authors.lastname: Pennings
mesh_terms: D000328:Adult; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials; D006168:Guinea Pigs; D006801:Humans; D008422:Materials Testing; D011140:Polyurethanes; D012867:Skin; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; C115016:polyetherurethane