title: Estradiol administration and the sexual activity of castrated male rhesus monkeys (Macaca mulatta).
abstract: To examine whether estradiol might be effective in maintaining sexual behavior after castration or after testosterone withdrawal, we have observed male rhesus monkeys during daily 1-hr tests alternately with each of two ovariectomized, estradiol-treated females (four males, four females, eight male-female pairs, 798 tests). Estradiol (2-5 micrograms/kg sc/day) or vehicle was administered in counterbalanced order immediately after castration and again immediately after withdrawal of testosterone propionate treatments (800 micrograms and 1.6 mg sc/day). There were no significant differences in behavior during vehicle and estradiol treatments to indicate that estradiol helped to maintain male sexual activity. Instead, estradiol treatment tended to interfere with the capacity to intromit. This supported the results of other studies, namely, that the systemic administration of estradiol does not enhance the sexual behavior of castrated male macaques, and raises questions about the role of both aromatization and estrogen receptors in the male primate brain.
authors.affiliation: Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30322.
authors.forename: R P
authors.initials: RP
authors.lastname: Michael
authors.forename: D
authors.initials: D
authors.lastname: Zumpe
authors.forename: R W
authors.initials: RW
authors.lastname: Bonsall
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009919:Orchiectomy; D010410:Penile Erection / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology
chemical_list: D013739:Testosterone; D004958:Estradiol