Carcinogenicity studies with deltamethrin in mice and rats.
The pesticide Deltamethrin, a synthetic pyrethroid, was studied for carcinogenicity in long-term experiments in mice and rats. Mice were given Deltamethrin by gavage in arachis oil at 0, 1, 4 or 8 mg/kg body wt for 2 years. A group of untreated controls was also available. Rats received 0, 3 or 6 mg/kg body wt. Deltamethrin in arachis oil for 2 years. In mice, an increased incidence of lymphomas was observed in the groups receiving 1 and 4 mg/kg body wt., but not in the group treated with 8 mg/kg body wt. Deltamethrin. In rats, an increased incidence of thyroid tumours was noted, but, no clear dose-response relationship was shown. Deltamethrin does not appear to be carcinogenic in mice or rats, but further studies are needed on the group of compounds to which this substance belongs.
Cabral
J R
JR
International Agency for Research on Cancer, Unit of Mechanisms of Carcinogenesis, Lyon, France.
Galendo
D
D
Laval
M
M
Lyandrat
N
N
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D013964:Thyroid Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin