title: Intracarotid amobarbital (Wada) test for language dominance: correlation with results of cortical stimulation.
abstract: Eighty-eight patients had bilateral intracarotid amobarbital (Wada) testing to determine hemispheric dominance for language in preparation for epilepsy surgery, as well as unilateral extraoperative cortical electrical stimulation using subdural electrode arrays. In none of the patients with left dominance by Wada testing were language areas found with right-sided stimulation, but two patients with right dominance by Wada testing had language areas mapped on the left side. These findings suggest that left dominance by Wada testing is strong evidence for exclusive lateralization of language function in the left hemisphere, but there is concern about the ability of the Wada test to exclude the possibility of some left-sided language function despite apparent right-sided dominance. Patients with left dominance on Wada testing do not need cortical stimulation before extensive right temporal lobectomy, but we believe that patients with right or bilateral dominance on Wada testing should have cortical stimulation for localization of language areas if extensive left or right temporal or frontal resection is planned.
authors.affiliation: Section of Epilepsy, Cleveland Clinic Foundation, Ohio 44195-5221.
authors.forename: E
authors.initials: E
authors.lastname: Wyllie
authors.forename: H
authors.initials: H
authors.lastname: Lüders
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.forename: H
authors.initials: H
authors.lastname: Morris
authors.forename: D
authors.initials: D
authors.lastname: Dinner
authors.forename: R
authors.initials: R
authors.lastname: Lesser
authors.forename: J
authors.initials: J
authors.lastname: Godoy
authors.forename: P
authors.initials: P
authors.lastname: Kotagal
authors.forename: A
authors.initials: A
authors.lastname: Kanner
mesh_terms: D000654:Amobarbital / Q000008:administration & dosage; D002339:Carotid Arteries; D002540:Cerebral Cortex / Q000502:physiology*; D004292:Dominance, Cerebral; D006801:Humans; D007802:Language
chemical_list: D000654:Amobarbital