Electrochemical treatment of cancer. III: Plasma pharmacokinetics of adriamycin after intraneoplastic administration.
Plasma pharmacokinetics of Adriamycin (doxorubicin) has been studied after intraneoplastic administration during electrochemical treatment to patients with lung cancer that is noncurable with radiotherapy, surgery, or chemotherapy. Intraneoplastic administration of Adriamycin via the anode resulted in a dramatic change of the pharmacokinetic pattern in plasma as compared with what has been previously observed after intravenous administration. A fivefold reduction of the area under the plasma concentration time curve and a 25-fold reduction of the maximum plasma concentration was observed.
Eksborg
S
S
Karolinska Pharmacy, Karolinska Hospital, Stockholm, Sweden.
Nordenström
B E
BE
Beving
H
H
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage* / Q000097:blood; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D007478:Iontophoresis; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D004317:Doxorubicin