[An evaluation of the toxic and antitumor action of farmorubicin administered to H-strain mice with Ehrlich ascitic cancer].
The toxic and antitumour action of farmorubicin was investigated in experiments on mice. Data on the high antitumor activity were obtained after single application of the drug and at 5-day treatment of mice bearing the Ehrlich ascites tumour. It has been established that farmorubicin used in the tolerant dose was comparatively nontoxic--nonmyelotoxic. At higher doses the toxic damages manifested in different periods and depended on the employed doses. A decrease in the heart weight has permitted revealing the formorubicin-induced cardiotoxicity which was confirmed (after 5 injections of the preparation in a dose of LD 50) by electron microscopy.
Karaivanova
M Kh
MKh
Prokopanov
Kh
Kh
Getov
Kh
Kh
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000401:mortality / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D015251:Epirubicin / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D013997:Time Factors
D015251:Epirubicin
Otsenka toksicheskogo i protivoopukholevogo deĭstviia farmorubitsina pri vvedenii mysham linii H s astsitnym rakom Erlikha.