Effects of rhodamine 6G on the mitochondrial ultrastructure of mouse spermatocytes.
Effects of rhodamine 6G on spermatocyte mitochondria were assessed in BALB/c mice in vivo. Four groups of mice were given rhodamine 6G doses of 0.0, 0.3 and 0.5 and 0.8 mg.kg-1.d-1 i.p. for 5 days. On the 5th day after the last day of dye administration, the mice were killed and testicular tissue was prepared for electron microscopy. Exposure to rhodamine 6G resulted in dose-dependent effects, primarily intracristal expansion of mitochondria.
Zhang
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WW
Department of Biology, University of Alabama, Tuscaloosa 35487-0344.
Hood
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RD
Smith-Sommerville
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HE
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure*; D012235:Rhodamines / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure*; D013737:Testis / Q000187:drug effects / Q000473:pathology; D014966:Xanthenes / Q000494:pharmacology*
D012235:Rhodamines; D014966:Xanthenes; C026188:rhodamine 6G