Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.
Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.
Conn
G
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Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
Bayne
M L
ML
Soderman
D D
DD
Kwok
P W
PW
Sullivan
K A
KA
Palisi
T M
TM
Hope
D A
DA
Thomas
K A
KA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004730:Endothelium, Vascular / Q000378:metabolism; D006023:Glycoproteins / Q000235:genetics* / Q000302:isolation & purification; D006133:Growth Substances / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D016133:Polymerase Chain Reaction; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D042461:Vascular Endothelial Growth Factor A
D006023:Glycoproteins; D006133:Growth Substances; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D004247:DNA