Vascularized periosteum associated with cancellous bone graft: an experimental study.
The association of a vascularized periosteal flap with a cancellous bone graft was studied on a group of 20 Wistar rats. Ten rats were sacrificed at 6 weeks and seven at 12 weeks (three died prematurely). The behavior of the cancellous bone graft buried in striated muscle and the osteogenic capacity of a simple vascularized periosteal flap also were observed on the same animals. Results of the study are as follows: In 14 of 17 animals, a vascularized periosteal flap wrapped around a cancellous bone graft resulted in new cortical bone formation with little resorption of the initial cancellous graft. A vascularized musculoperiosteal flap has produced a small amount of new compact bone only in 4 of 17 animals. A cancellous bone graft buried into well-vascularized muscle tissue was resorbed (15 cases) or necrotic (2 cases) at 12 weeks. In conclusion, the association of a vascularized periosteal flap and cancellous bone is a better means to produce compact bone than a vascularized periosteal flap alone or an isolated cancellous bone graft.
Romana
M C
MC
Department of Orthopedic Surgery, Hôpital Trousseau, Paris, France.
Masquelet
A C
AC
D000818:Animals; D016025:Bone Transplantation; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D005121:Extremities; D005260:Female; D008297:Male; D010012:Osteogenesis; D010521:Periosteum / Q000098:blood supply / Q000637:transplantation*; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps / Q000379:methods*