Synthesis and pharmacological studies of N-[4-[2-hydroxy-3-[[2-[4-(1H-imidazol-1- yl)phenoxy]ethyl]amino]propoxy]phenyl]methanesulfonamide, a novel antiarrhythmic agent with class II and class III activities.
Morgan
T K
TK
Berlex Laboratories, Inc., Cedar Knolls, New Jersey 07927.
Lis
R
R
Lumma
W C
WC
Wohl
R A
RA
Nickisch
K
K
Phillips
G B
GB
Lind
J M
JM
Lampe
J W
JW
Di Meo
S V
SV
Reiser
H J
HJ
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004594:Electrophysiology; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D011690:Purkinje Fibers / Q000187:drug effects / Q000502:physiology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D011412:Propanolamines; D013449:Sulfonamides; C063532:ersentilide