Histological changes in the vas deferens of rats after injection of a new male antifertility agent "SMA" and its reversibility.
A new male antifertility agent, styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide (DMSO), was injected into the vas deferens of rats. The morphological changes detected were confined only to the mucosa. After four weeks, the vas deferens lumen was flushed with the solvent DMSO, and the mucosal structures returned to normal.
Sethi
N
N
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Srivastava
R K
RK
Singh
R K
RK
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D011137:Polystyrenes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013243:Sterilization Reversal; D013245:Sterilization, Reproductive / Q000379:methods; D014649:Vas Deferens / Q000166:cytology / Q000187:drug effects*
D003272:Contraceptive Agents, Male; D008298:Maleates; D011137:Polystyrenes; C024074:styrene-maleic acid polymer