Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment.
Serum apolipoproteins A (Apo-A) and B (Apo-B) and lecithin: cholesterol acyl transferase (LCAT) activities and 24-hour urinary cholesterol levels were estimated in 25 nephrotic children before and during steroid treatment with 4 weeks of daily prednisolone followed by another 4 weeks of alternate-day prednisolone. The patients with untreated nephrotic syndrome (NS) showed significant decrease in serum Apo-A and LCAT activities associated with significant increase in serum Apo-B and urinary cholesterol levels compared to healthy controls (n = 25). Serum Apo-A levels correlated directly and Apo-B levels inversely with the serum albumin concentrations. After a transient elevation, the serum Apo-A level returned to control range by 8 weeks of treatment accompanied by a gradual increase in serum LCAT activity and decrease in urinary cholesterol excretion. Though, the serum Apo-B level was decreased with treatment, it was still significantly high compared to the controls.
Nayak
S S
SS
Department of Clinical Biochemistry, Kasturba Medical College, Manipal, India.
Bhaskaranand
N
N
Kamath
K S
KS
Baliga
M
M
Venkatesh
A
A
Aroor
A R
AR
D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use; D013997:Time Factors
D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002784:Cholesterol; D011239:Prednisolone; D007862:Phosphatidylcholine-Sterol O-Acyltransferase