title: Altromycins, novel pluramycin-like antibiotics. I. Taxonomy of the producing organism, fermentation and antibacterial activity.
abstract: The altromycins are novel anthraquinone-derived antibiotics related to the pluramycins. They are produced by an actinomycete, AB 1246E-26, which was isolated from a South African bushveld soil. The altromycins have Gram-positive antibacterial activity with MICs of 0.2 to 3.12 micrograms/ml against Streptococci and Staphylococci.
authors.affiliation: Anti-infective Research Division, Abbott Laboratories, IL 60064.
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: J P
authors.initials: JP
authors.lastname: Karwowski
authors.forename: R J
authors.initials: RJ
authors.lastname: Theriault
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardy
authors.forename: S J
authors.initials: SJ
authors.lastname: Swanson
authors.forename: G J
authors.initials: GJ
authors.lastname: Barlow
authors.forename: P M
authors.initials: PM
authors.lastname: Tillis
authors.forename: J B
authors.initials: JB
authors.lastname: McAlpine
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005285:Fermentation; D012988:Soil Microbiology; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C063716:altromycin A; C063718:altromycin C; C063717:altromycin B; C063719:altromycin D