Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes.
We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L2C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.
Sainte-Marie
J
J
URA-CNRS 530, Dept. Biologie Santé USTL, Montpellier, France.
Vignes
M
M
Vidal
M
M
Philippot
J R
JR
Bienvenüe
A
A
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D019905:Benzyl Alcohol; D001592:Benzyl Alcohols / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D004705:Endocytosis / Q000187:drug effects*; D006168:Guinea Pigs; D006801:Humans; D007501:Iron / Q000378:metabolism; D007942:Leukemia, Experimental / Q000503:physiopathology*; D008077:Lipoproteins, LDL / Q000378:metabolism; D011973:Receptors, LDL / Q000187:drug effects* / Q000502:physiology; D011990:Receptors, Transferrin / Q000187:drug effects* / Q000502:physiology; D014168:Transferrin / Q000378:metabolism
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron; D019905:Benzyl Alcohol