[The absorbed dosage and its fractionation in the radiation treatment of tumors in children].
Radiation therapy is widely used in pediatric oncology. Its use emphasizes the problems of the protection of growing tissues and organs. The paper is concerned with the problem of effective distribution of an ionizing radiation dose delivered to a locally advanced tumor in children. Analysis of the literature and authors' data show that the growing organs of a child are 2-2.5-fold more sensitive than the same organs of an adult. Besides some organs and tissues at various ages of a child possess a various degree of maturity. Therefore it is proposed that small single doses (0.6-1 Gy) that can be delivered 2-3 times a day, should be used in pediatric oncology. A scheme of dynamic irradiation of radiosensitive and resistant tumors of children was prepared and tested under clinical conditions.
Goldobenko
G V
GV
Ivanov
V K
VK
Durenov
L A
LA
Lobanov
G V
GV
Waĭnson
A A
AA
D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000532:radiotherapy*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013997:Time Factors
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