Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats.
Brain regional glucose metabolism and regional blood flow were measured from autoradiographs by the uptake of [3H]-2-deoxy-D-glucose and [14C]iodoantipyrine in streptozocin-induced diabetic (STZ-D) rats. After 2 days of diabetes, glucose metabolism in the neocortex, basal ganglia, and white matter increased by 34, 37, and 8%, respectively, whereas blood flow was unchanged. After 4 mo, glucose metabolism in the same three regions was decreased by 32, 43, and 60%. This reduction was paralleled by a statistically nonsignificant reduction in blood flow in neocortex and basal ganglia. It is suggested that the decrease of brain glucose metabolism in STZ-D reflects increased ketone body oxidation and reduction of electrochemical work.
Jakobsen
J
J
Institute of Neuropathology, University of Copenhagen, Denmark.
Nedergaard
M
M
Aarslew-Jensen
M
M
Diemer
N H
NH
D000375:Aging; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000378:metabolism; D001345:Autoradiography; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012039:Regional Blood Flow; D014316:Tritium
D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D014316:Tritium; D003847:Deoxyglucose; D000983:Antipyrine; C008135:iodoantipyrine