title: Lipid A, the immunostimulatory principle of lipopolysaccharides?
abstract: Lipid A has been found to be an inducer of IL-1 with similar potency as LPS. Partial structures of lipid A or core oligosaccharides are less active or not active at all. We propose that lipid A is the structure responsible for induction of immunostimulatory or immunoregulatory properties of LPS.
authors.affiliation: Forschungsinstitut Borstel, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Loppnow
authors.forename: I
authors.initials: I
authors.lastname: Dürrbaum
authors.forename: H
authors.initials: H
authors.lastname: Brade
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: S
authors.initials: S
authors.lastname: Kusumoto
authors.forename: E T
authors.initials: ET
authors.lastname: Rietschel
authors.forename: H D
authors.initials: HD
authors.lastname: Flad
mesh_terms: D000276:Adjuvants, Immunologic; D002240:Carbohydrate Sequence; D002448:Cell Adhesion; D007375:Interleukin-1 / Q000096:biosynthesis; D008050:Lipid A / Q000276:immunology / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D008969:Molecular Sequence Data
chemical_list: D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides