Cyclosporin for treatment of life-threatening alloimmunization.
We describe a 16-year-old girl with aplastic anemia who, 1 year after initial diagnosis developed a refractory state to platelet transfusions due to alloimmunization and resulting in severe bleeding. Treatment with cyclosporin, initially prescribed as treatment of the bone marrow failure, resulted in prompt decrease in lymphocytotoxic antibodies, which paralleled a marked improvement in platelet recovery. To our knowledge, such a dramatic effect of cyclosporin on alloimmunization has not been previously reported and merits further attention.
Tilly
H
H
Service d'Hématologie, Centre Henri Becquerel, Rouen, France.
Azagury
M
M
Bastit
D
D
Lallemand
A
A
Piguet
H
H
D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology*; D003524:Cyclosporins / Q000627:therapeutic use*; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D004285:Dogs; D005260:Female; D006801:Humans; D017713:Platelet Transfusion; D065227:Transfusion Reaction
D000961:Antilymphocyte Serum; D003524:Cyclosporins