title: [Stage 1 and 2 cancers of the endometrium. Value of the combination of pelvic radiotherapy and curietherapy followed by a total hysterectomy without lymph node removal].
abstract: In a retrospective study of 108 patients with stage I-II EC, treated between 1976 and 1983 at CGFL (Dijon), we performed an analysis of the efficacy and tolerance of a treatment approach consisting of external and intracavitary pelvic irradiation followed, 6 weeks later, by hysterectomy without lymph node dissection. Forty-three patients underwent this treatment sequence (G1) and 65 patients (G2) were treated by other modalities (33 intracavitary irradiation and hysterectomy, 27 hysterectomy alone or followed by pelvic irradiation, 5 irradiation alone). The mean follow-up was seven years (5-12). The five year total actuarial survival rate was 82% for G1 and 74% for G2 (p = NS). The five-year disease-free survival probability was 80% for G1 and 67% for G2 (p less than 0.05). The post-therapy complications were 2% for G1 (one late post-irradiation complication) and 14% for G2 (one late post-irradiation complication and 6 post-surgical complications). Although G1 group has more pejorative clinical and histopathological features (72% T1b or T2 for G1 vs 42% for G2 (p less than 0.005) and 77% grade 2 or 3 for G1 vs 61% for G2 (p = 0.05], the efficacy and tolerance of EIH treatment sequence appear at least comparable to those of G2. These results redefine certain therapeutic aspects of stage I-II endometrial carcinoma which should be considered in future prospective approaches.
authors.affiliation: Centre Georges-François-Leclerc, Dijon.
authors.forename: S
authors.initials: S
authors.lastname: Douvier
authors.forename: J
authors.initials: J
authors.lastname: Cuisenier
authors.forename: J M
authors.initials: JM
authors.lastname: Nabholtz
authors.forename: A
authors.initials: A
authors.lastname: Perez
authors.forename: E
authors.initials: E
authors.lastname: Bréchet
authors.forename: J C
authors.initials: JC
authors.lastname: Horiot
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
vernacular_title: Les cancers de l'endomètre stade 1 et 2. Intérêt de l'association radiothérapie pelvienne, curiethérapie suivie d'une hystérectomie totale sans curage ganglionnaire.