title: [The mechanisms of a decrease in the toxic action of cisplatin when administered jointly with preparation K-2-9 to mice with melanoma B16].
abstract: The K-2-9 preparation was determined to change cis-platinum pharmacokinetics, that resulted in its pharmacodynamics alterations. The higher Pt concentrations in the blood of animals which were given the K-2-9 preparation provided selectivity of cytostatic accumulation in the tumour tissue, that was accompanied by more prolonged inhibition of the DNA synthesis. A decrease in the toxicity of cis-platinum is associated with a change in the elimination pathway and acceleration of its removal from the organism.
authors.forename: V F
authors.initials: VF
authors.lastname: Chekhun
authors.forename: F P
authors.initials: FP
authors.lastname: Pel'kis
authors.forename: E A
authors.initials: EA
authors.lastname: Serebriakova
authors.forename: A S
authors.initials: AS
authors.lastname: Singin
authors.forename: I S
authors.initials: IS
authors.lastname: Sokolova
authors.forename: G Z
authors.initials: GZ
authors.lastname: Negreĭ
authors.forename: G I
authors.initials: GI
authors.lastname: Kulik
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D002945:Cisplatin
vernacular_title: O nekotorykh mekhanizmakh snizheniia toksicheskogo deĭstviia tsisplatina pri sovmestnom vvedenii s preparatom K-2-9 mysham s melanomoĭ B-16.