Failure to acquire an inhibitory task following seizure-induced brain damage.
Male rats that had displayed limbic seizures following a single pair of systemic injections of lithium and pilocarpine were trained 2 months later on an operant schedule that required differential low rates of responding (DRL). The seizured rats never acquired schedules that required either 6-sec. or 12-sec. inhibition of responses following a reward; these rats displayed more perseverative responding and shorter interresponse times than controls. Histomorphology indicated severe brain damage primarily within the entorhinal cortices (and adjacent amygdala) and dorsal thalamus.
Harrigan
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T
Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
Peredery
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O
Persinger
M A
MA
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D001931:Brain Mapping; D003216:Conditioning, Operant / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*