title: Multiple molecular forms of rat liver glucose-6-phosphate dehydrogenase during liver hyperplasia induced by lead nitrate.
abstract: In the present study the three dimeric molecular forms of rat liver glucose-6-phosphate dehydrogenase were investigated during liver hyperplasia induced by lead nitrate. An increase of band 3 and a concomitant decrease of band 1 was found, indicating that this proliferating process is characterized by a peculiar pattern in the distribution of liver G6PD activity. Since the same pattern was observed also in liver hyperplasia induced in fasted animals, a condition otherwise characterized by a shift towards band 1, we suggest that during proliferating processes the metabolic control normally exerted by fasting on the enzymatic activity is overcome.
authors.affiliation: Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Batetta
authors.forename: S
authors.initials: S
authors.lastname: Dessì
authors.forename: D
authors.initials: D
authors.lastname: Pulisci
authors.forename: A
authors.initials: A
authors.lastname: Carrucciu
authors.forename: P
authors.initials: P
authors.lastname: Pani
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005215:Fasting / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006965:Hyperplasia / Q000139:chemically induced; D007527:Isoenzymes / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000473:pathology*; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007527:Isoenzymes; D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D005954:Glucosephosphate Dehydrogenase