Stepwise oligogenic segregation and linkage analysis illustrated with dopamine-beta-hydroxylase activity.
A stepwise oligogenic method is developed that can be used to adjust the phenotype of a quantitative trait for the effects of a previously identified single-locus component. This method assumes that a single-locus component can be adequately identified through the use of segregation and/or linkage analysis under a 1-locus model and that the variation due to that locus can be removed from the phenotype leaving a residual that can be parameterized in terms of an additional single-locus component. Segregation and/or linkage analysis can then be used in an attempt to identify an additional single-locus component in the residual phenotype. This stepwise process can be repeated until no further single-locus effects are identified. The method is illustrated using family data on the specific activity of dopamine-beta-hydroxylase (DBH), which a number of studies have suggested may be due either to the combined effects of single-locus and multifactorial components or to the combined effects of 2 loci.
Wilson
A F
AF
Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112-1393.
Elston
R C
RC
Sellers
T A
TA
Bailey-Wilson
J E
JE
Gersting
J M
JM
Deen
D K
DK
Sorant
A J
AJ
Tran
L D
LD
Amos
C I
CI
Siervogel
R M
RM
D003434:Crossing Over, Genetic; D004299:Dopamine beta-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D011995:Recombination, Genetic
D004299:Dopamine beta-Hydroxylase