title: Response of fibronectin to liver regeneration after hepatectomy.
abstract: The relationship between plasma fibronectin concentration and the regenerative process in liver remnants after hepatectomy was studied in 12 patients and in male Sprague-Dawley rats with and without cirrhosis. Plasma fibronectin levels were reduced immediately after hepatectomy in humans and rats. Patients and rats without cirrhosis displayed preoperative fibronectin levels within 1 mo and 1 wk, respectively, but low fibronectin levels persisted longer in those with cirrhosis. Plasma fibronectin levels correlated well with the degree of hepatic regeneration in the patients with cirrhosis (r = 0.4227; p less than 0.05) and without cirrhosis (r = 0.8148; p less than 0.001), and also with the percentage of change in liver weight during regeneration in the rat with thioacetamide-induced cirrhosis (r = 0.4905; p less than 0.01) or in the rat without cirrhosis (r = 0.6422; p less than 0.001). These results suggest that plasma fibronectin is a useful marker for the detection of regenerating liver.
authors.affiliation: Department of Surgery, Kansai Medical University, Osaka, Japan.
authors.forename: A H
authors.initials: AH
authors.lastname: Kwon
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
authors.forename: S
authors.initials: S
authors.lastname: Uetsuji
authors.forename: M
authors.initials: M
authors.lastname: Yamamura
authors.forename: K
authors.initials: K
authors.lastname: Hioki
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D014057:Tomography, X-Ray Computed
chemical_list: D005353:Fibronectins