Platelet thromboxane release after subarachnoid hemorrhage and surgery.
We studied adenosine diphosphate-induced platelet aggregation and the associated release of thromboxane B2 in platelet-rich plasma from 88 patients with subarachnoid hemorrhage and 26 healthy controls. During the first 3 days after subarachnoid hemorrhage, the patients showed significantly decreased (p less than 0.05) platelet aggregability and thromboxane release relative to the controls, but these effects disappeared in a few days. Platelet count increased for 3 weeks after subarachnoid hemorrhage. Surgery in 67 patients was followed by significant increases in platelet aggregability (p less than 0.05) and thromboxane release (p less than 0.001). Greatest thromboxane release was found in the eight patients showing delayed (postoperative) ischemic deterioration with a permanent neurologic deficit. Although platelet hyperaggregability and increased thromboxane release were particularly prominent in these eight patients, the role of these hematologic parameters in the pathogenesis of delayed ischemic deterioration remains unclear.
Juvela
S
S
Departments of Neurosurgery, Helsinki University Central Hospital, Finland.
Kaste
M
M
Hillbom
M
M
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D002545:Brain Ischemia / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011183:Postoperative Complications; D011184:Postoperative Period; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D013929:Thromboxane B2 / Q000097:blood*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013929:Thromboxane B2