title: Cutaneous responses to histamine, compound 48/80 and codeine in patients with hyperthyroidism.
abstract: The regulatory effects of various endocrine factors on allergic processes have been widely studied. The clinical importance of hyperthyroidism in asthma and in chronic urticaria has been demonstrated in several cases. These observations may be attributed to modulatory effects of thyroid hormones on mast cell releasability and/or on other target organs as blood vessels. To evaluate the effects of thyroid hormones on mast cell releasability and on the cutaneous vasculature, we analyzed the wheal and flare response to compound 48/80, to codeine, and to histamine in patients with hyperthyroidism and in a control group. No significant difference was found between the two groups. We could not demonstrate any in vivo effect of the thyrotoxic state on the cutaneous response to these substances.
authors.affiliation: Allergy-Immunology Unit, Meir General Hospital, Kfar Saba, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Goldberg
authors.forename: M
authors.initials: M
authors.lastname: Shapiro
authors.forename: I
authors.initials: I
authors.lastname: Hammel
authors.forename: Y A
authors.initials: YA
authors.lastname: Mekori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003061:Codeine / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications* / Q000276:immunology; D006980:Hyperthyroidism / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
chemical_list: D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D003061:Codeine