title: Systemic lupus erythematosus presenting as pneumococcal septicaemia and septic arthritis.
abstract: A 50 year old woman presented with pneumococcal septicaemia, septic arthritis, and a lobar pneumonia and was subsequently diagnosed as having systemic lupus erythematosus. The blood film and splenic 99mTc sulphur colloid uptake were normal, although selective functional hyposplenism was shown by the impaired clearance of immunoglobulin coated erythrocytes. Systemic lupus erythematosus presenting with fulminating pneumococcal sepsis in the presence of selective defects in spleen function is previously unreported.
authors.affiliation: Department of Medicine, University Hospital of Wales, Heath Park, Cardiff.
authors.forename: J
authors.initials: J
authors.lastname: Webster
authors.forename: B D
authors.initials: BD
authors.lastname: Williams
authors.forename: A P
authors.initials: AP
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Hall
authors.forename: J D
authors.initials: JD
authors.lastname: Jessop
mesh_terms: D001170:Arthritis, Infectious / Q000150:complications*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000150:complications*; D011018:Pneumonia, Pneumococcal / Q000150:complications; D011961:Receptors, Fc / Q000502:physiology; D018805:Sepsis / Q000150:complications*; D013154:Spleen / Q000503:physiopathology
chemical_list: D011961:Receptors, Fc