Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Morse
M A
MA
Section of Nucleic Acid Chemistry, American Health Foundation, Valhalla, New York 10595.
Hecht
S S
SS
Chung
F L
FL
D000818:Animals; D004247:DNA / Q000187:drug effects*; D017879:Isothiocyanates; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008745:Methylation; D051379:Mice; D008805:Mice, Inbred A; D009602:Nitrosamines / Q000633:toxicity; D009669:Nose Neoplasms / Q000139:chemically induced; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D013861:Thiocyanates / Q000494:pharmacology / Q000627:therapeutic use*
D017879:Isothiocyanates; D009602:Nitrosamines; D013861:Thiocyanates; C005441:phenylisothiocyanate; C058305:phenethyl isothiocyanate; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; C031403:benzyl isothiocyanate; D004247:DNA