Analgesic activity of certain flavone derivatives: a structure-activity study.
Flavone and 10 hydroxy and glucoside flavone derivatives were synthesised. They were tested for their analgesic effect in mice employing acetic acid-induced writhing and tail immersion methods. Subcutaneously all the tested compounds exhibited significant analgesic activity with varying potencies in both assay models. The activity of flavone and its 5-; 7-; 2'-; 5,7- and 7,8-hydroxy derivatives apparently involves an opiate-like mechanism, since their activity was reversed by naloxone pretreatment. It is suggested that flavonoid substances may utilise more than one mechanism in eliciting analgesia.
Thirugnanasambantham
P
P
Medicinal Chemistry Research Centre, Madras Medical College, India.
Viswanathan
S
S
Mythirayee
C
C
Krishnamurty
V
V
Ramachandran
S
S
Kameswaran
L
L
D000700:Analgesics; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011292:Premedication; D013329:Structure-Activity Relationship
D000700:Analgesics; D005419:Flavonoids; D005960:Glucosides; D009270:Naloxone; D009020:Morphine