title: [Pregnancy and labor in idiopathic thrombocytopenic purpura (Werlhof disease)].
abstract: The managing of the pregnant patient with immune thrombocytopenic purpura (ITP) is complicated by the unavailability of the foetal platelet count and the risk of bleeding. We report on our experiences of 17 pregnancies in 15 patients, who delivered in the Department of Gynaecology of Freiburg University from 1969 to 1989 (frequency: 0.5 per 1,000). ITP was established prior to pregnancy in 9 of 15 patients, and developed in 6 cases during pregnancy. The a patients received steroid therapy ante partum. However, maternal platelet count did not relate to infant platelet count. Eleven infants were born vaginally, six by caesarean section. One of the 17 live births died immediately post partum at the 28th week of gestation. Six infants were temporarily thrombocytopenic at delivery without further morbidity. Based on our experience and the literature, an individual management of delivery for parturient patients with ITP is recommended.
authors.affiliation: Universitäts-Frauenklinik, Freiburg.
authors.forename: W
authors.initials: W
authors.lastname: Kleine
authors.forename: U
authors.initials: U
authors.lastname: Hambüchen
authors.forename: H G
authors.initials: HG
authors.lastname: Hillemanns
mesh_terms: D001803:Blood Transfusion; D002585:Cesarean Section; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D007744:Obstetric Labor Complications / Q000097:blood* / Q000628:therapy; D007752:Obstetric Labor, Premature / Q000097:blood; D010976:Platelet Count / Q000187:drug effects; D017713:Platelet Transfusion; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000628:therapy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids
vernacular_title: Schwangerschaft und Geburt bei idiopathischer thrombozytopenischer Purpura (M. Werlhof).