title: Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary.
abstract: Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter----cen----q23::q13----q23::q13----q23::?), +12, + der(13)t(13;15)(q21;q15), -15,der(16) (16qter----cen----16p13::hsr::8q21----8qter), +19, + der(20)t(X;20)(q13;p13), -22, +4 - 6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Pejovic
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: U M
authors.initials: UM
authors.lastname: Flodérus
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000368:Aged; D002454:Cell Differentiation; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008648:Mesoderm; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D012509:Sarcoma / Q000235:genetics / Q000473:pathology
chemical_list: D005819:Genetic Markers