[The effect of dimephosphon on exudative and proliferative processes].
The effects of dimephosphon on the models of inflammation which permitted the separation of the exudative and proliferative phases were studied on rats. The drug effect on the levels of histamine, serotonin and their precursors in blood of healthy rats was also investigated. Dimephosphon was found to exert no inhibitory influence on the proliferative reaction in contrast to the well-known non-steroidal anti-inflammatory drugs. The antihistamine activity of dimephosphon occurring on account of the intensification of histaminopexy was established. It is suggested that the antihistamine activity of dimephosphon should be used for therapeutic purposes.
Ziganshina
L E
LE
Studentsova
I A
IA
Zaikonnikova
I V
IV
Ziganshin
A U
AU
Popova
L G
LG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005122:Exudates and Transudates / Q000187:drug effects* / Q000378:metabolism; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism; D006099:Granuloma / Q000188:drug therapy* / Q000378:metabolism; D006632:Histamine / Q000097:blood; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000097:blood; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009943:Organophosphorus Compounds; C049638:dimephosphon; D012701:Serotonin; D006632:Histamine
Vliianie dimefosfona na protsessy ékssudatsii i proliferatsii.