Inhibitory effects of benomyl and carbendazim on the [3H]thymidine incorporation in various organs of the mouse--evidence for a more pronounced action of benomyl.
The benzimidazole fungicides benomyl and carbendazim were compared with regard to effects on [3H]thymidine incorporation in various organs of male mice given the compounds orally at various time intervals before sacrifice. Since carbendazim is a major metabolite of benomyl, it is generally assumed that the fungicidal action and toxicity of these compounds are due to the action of carbendazim. However, whereas benomyl inhibited the [3H]thymidine incorporation into thymus, spleen, liver, kidney and testis, an equimolar amount (3.4 mmol/kg body wt) of carbendazim induced a similar effect only in testis.
Hellman
B
B
Department of Toxicology, Uppsala university, Sweden.
Laryea
D
D
D000818:Animals; D001542:Benomyl / Q000633:toxicity*; D001562:Benzimidazoles / Q000633:toxicity*; D002219:Carbamates / Q000633:toxicity*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects
D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; D004247:DNA; C006698:carbendazim; D001542:Benomyl; D013936:Thymidine