[Aplastic anemia probably induced by allopurinol in a patient with renal insufficiency].
A rare case of aplastic anemia which was considered to be induced by allopurinol was reported. A 48-year-old female had suffered from urolithiasis and chronic renal insufficiency. She was administered allopurinol for hyperuricemia for 4 months, and subsequently developed severe pancytopenia and bone marrow suppression. After stopping of allopurinol administration, she was administered prednisolone but died of gastro-intestinal tract bleeding and sepsis on the 21th hospital day, without hematological recovery.
Okafuji
K
K
Department of Hematology, Central Hospital of Yamaguchi Prefecture.
Shinohara
K
K
D000493:Allopurinol / Q000009:adverse effects*; D000741:Anemia, Aplastic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000493:Allopurinol