title: Squamous syringometaplasia in lobular panniculitis and pyoderma gangrenosum.
abstract: Squamous metaplasia of eccrine sweat glands has been most frequently described in chronic cutaneous ulcerations with associated epidermal hyperplasia. We found examples of the process in skin biopsy specimens from five patients: three had associated lobular panniculitis and two had lesions of pyoderma gangrenosum. The metaplasia was located in the mid-to-deep reticular dermis in all five patients and extended into the superficial subcutis in one. Immunohistochemical stains for CEA and S-100 protein were used to accentuate the relationship of the metaplastic islands with eccrine ducts. It is postulated that necrosis of a portion of the eccrine duct is the stimulus for this process.
authors.affiliation: Department of Dermatology, Medical University of South Carolina, Charleston 29425.
authors.forename: J S
authors.initials: JS
authors.lastname: Metcalf
authors.forename: J C
authors.initials: JC
authors.lastname: Maize
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002135:Calcium-Binding Proteins / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D015434:Panniculitis / Q000473:pathology*; D011711:Pyoderma / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D013544:Sweat Gland Neoplasms / Q000473:pathology*
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D002272:Carcinoembryonic Antigen; C030564:S-100 calcium-binding protein alpha subunit; D009418:S100 Proteins