Genetic control of nickel sulfate delayed-type hypersensitivity.
Genetic control of delayed-type hypersensitivity (DTH) to nickel sulfate antigen was studied using various strains on inbred mice. Mice with class II Ad,k,s haplotypes showed a high magnitude of response, whereas those with class II Ab,f were low responders. These results indicate that nickel sulfate DTH may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+, Lyt-2- T cells.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Kanagawa, Japan.
Ishii
H
H
Ono
H
H
Horiuchi
Y
Y
Nakajima
H
H
Aoki
I
I
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000235:genetics*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009532:Nickel / Q000009:adverse effects* / Q000097:blood / Q000276:immunology
D000911:Antibodies, Monoclonal; C029938:nickel sulfate; D009532:Nickel