A simple method for measuring patient anti-globulin responses against isotypic or idiotypic determinants.
A simple inhibition of capture enzyme-linked immunosorbent assay (IOC-ELISA) was developed which permitted the independent measurement of anti-idiotypic and anti-isotypic antiglobulins in serum samples from patients receiving therapeutic monoclonal antibodies.
Cobbold
S P
SP
Department of Pathology, Cambridge University, U.K.
Rebello
P R
PR
Davies
H F
HF
Friend
P J
PJ
Clark
M R
MR
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D001710:Biotin; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007132:Immunoglobulin Isotypes; D001710:Biotin