Cerebrovascular effect of calcium antagonists.
Activity of calcium antagonists was assessed in microvessels (internal diameter 5-50 microns) isolated from rat brain. High KCl solution induced an increase of the lanthanum-resistant 45Ca influx and a marked reduction in microvessel diameter. Both responses to depolarization were inhibited by the calcium antagonists nimodipine and flunarizine. Binding studies with 3H(+)PN200-110 used as a specific ligand of Ca channels revealed the existence of voltage-dependent, stereoselective binding sites for dihydropyridine calcium antagonists.
Morel
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Laboratoire de Pharmacodynamie Générale et de Pharmacologie, Université Catholique de Louvain, Bruxelles, Belgique.
Godfraind
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T
D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005444:Flunarizine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats
D002121:Calcium Channel Blockers; D009553:Nimodipine; D007811:Lanthanum; D005444:Flunarizine; D002118:Calcium