title: The distribution of changes in local cerebral energy metabolism associated with brain stimulation reward to the medial forebrain bundle of the rat.
abstract: Using the quantitative 2-[14C]deoxyglucose autoradiographic method, local rates of glucose utilization were measured in rats during brain stimulation reward to the medial forebrain bundle. Metabolic activation was observed both rostral and caudal to the site of stimulation. These sites included the nucleus accumbens, olfactory tubercle, lateral septum, and ventral tegmental area. In many cases, increases in glucose utilization occurred bilaterally. These data suggest the involvement of both ascending and descending systems in brain stimulation reward. Furthermore, despite the unilateral nature of the electrical stimulation, increases in glucose utilization were observed both ipsilateral and contralateral to the site of stimulation.
authors.affiliation: Unit on Brain Imaging, National Institute on Neurological Disorders and Stroke, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: L J
authors.initials: LJ
authors.lastname: Porrino
authors.forename: D
authors.initials: D
authors.lastname: Huston-Lyons
authors.forename: G
authors.initials: G
authors.lastname: Bain
authors.forename: L
authors.initials: L
authors.lastname: Sokoloff
authors.forename: C
authors.initials: C
authors.lastname: Kornetsky
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004558:Electric Stimulation; D004734:Energy Metabolism; D008297:Male; D008474:Medial Forebrain Bundle / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D012201:Reward
chemical_list: D003837:Deoxy Sugars; D003847:Deoxyglucose