Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity in axotomized motoneurons.
By use of fluorescence immunohistochemistry it is shown that sciatic nerve section in cat and rat induces increased levels of immunoreactive calcitonin gene-related peptide (CGRP) in axotomized motoneurons. In the rat, this effect was clearly seen at 2-5 days postoperatively, but could not be demonstrated after 11-21 days. These findings are discussed in relation to previously proposed roles for CGRP in motoneurons.
Arvidsson
U
U
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Johnson
H
H
Piehl
F
F
Cullheim
S
S
Hökfelt
T
T
Risling
M
M
Terenius
L
L
Ulfhake
B
B
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002415:Cats; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology*
D015740:Calcitonin Gene-Related Peptide