title: Selective uptake of gamma-[3H]aminobutyric acid by neural elements and vascular nerves of the rat intestinal submucosa.
abstract: Laminae of the rat intestinal submucosa were examined autoradiographically for gamma-[3H]aminobutyric acid ([3H]GABA) high-affinity uptake sites. In the presence of 10(-3) M beta-alanine, to prevent high-affinity uptake and localization of radiolabelled GABA by glia. [3H]GABA was accumulated into elements of Henle's or Schabadasch's plexus, and vascular nerves. Densely labelled fibres in the nerve plexus could be followed through the ganglia and interconnecting fasciculi, and often formed a dense neuropil in the ganglia. Cell soma were never labelled. Densely labelled fibres of the nerve plexus were sometimes found to be contiguous with fibres coursing with the blood vessels. All labelling could be prevented by the neural specific high-affinity uptake blocker, L-diaminobutyric acid (L-DABA; 10(-3) M).
authors.affiliation: Department of Physiology, University of Ottawa, Ont., Canada.
authors.forename: A
authors.initials: A
authors.lastname: Krantis
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D007413:Intestinal Mucosa / Q000098:blood supply / Q000294:innervation*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013368:Submucous Plexus / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid