Familial macrothrombocytopenia associated with decreased glycosylation of platelet membrane glycoprotein IV.
A case of hereditary thrombocytopenia with large platelets (familial macrothrombocytopenia, FM) is reported. Studies on the platelets from the propositus showed decreased glycosylation of platelet membrane glycoprotein IV, which would distinguish the case from other FM previously described.
Yufu
Y
Y
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan.
Ideguchi
H
H
Narishige
T
T
Suematsu
E
E
Toyoda
K
K
Nishimura
J
J
Nawata
H
H
Oda
S
S
D002869:Chromosome Aberrations / Q000097:blood; D025063:Chromosome Disorders; D005192:Family Health; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D013921:Thrombocytopenia / Q000235:genetics*
D010980:Platelet Membrane Glycoproteins