Severe symmetric intrauterine growth retardation associated with the topical use of triamcinolone.
Triamcinolone acetonide, a fluorinated glucocorticoid, when given in large parenteral doses has produced structural anomalies and severe growth retardation in nonhuman primates. We present a case report of a gravid patient who applied 40 mg/day of triamcinolone cream because of atopic dermatitis from 12 to 29 weeks' gestation. The infant was symmetrically growth retarded, possibly from exposure to triamcinolone acetonide. There was no evidence of hypoxic, chromosomal, or infectious cause of the growth delay.
Katz
V L
VL
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.
Thorp
J M
JM
Bowes
W A
WA
D000287:Administration, Topical; D000328:Adult; D003876:Dermatitis, Atopic / Q000188:drug therapy; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D006801:Humans; D009824:Ointments; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D014221:Triamcinolone / Q000008:administration & dosage / Q000009:adverse effects*
D009824:Ointments; D014221:Triamcinolone