Mirror polydactyly: pathogenesis based on a morphogen gradient theory.
We report on an infant with 7 toes of the left foot in a mirror configuration in association with ipsilateral duplication of the calcaneus and fibula, tibial aplasia, femoral hypoplasia, and a teratomatous sacrococcygeal tumour. The possible pathogenetic mechanisms leading to this limb abnormality are discussed with special emphasis on a field morphogen gradient hypothesis.
Viljoen
D L
DL
Department of Human Genetics, University of Cape Town Medical School, Observatory, South Africa.
Kidson
S H
SH
D005260:Female; D005532:Foot Deformities, Congenital / Q000196:embryology*; D006801:Humans; D007223:Infant; D007866:Leg / Q000002:abnormalities*; D009024:Morphogenesis; D010384:Pelvic Bones / Q000002:abnormalities*