title: [Nosocomial Staphylococcus epidermidis and Staphylococcus aureus septicemias in neonates].
abstract: Sixteen neonates developed staphylococcal septicemia (S. epidermidis in 10 cases and S. aureus in six). Two infections were due to maternofetal contamination and four to contaminated foreign material. Clinical symptoms included non-specific evidence of neonatal bacterial infection and, in S. aureus infections, suggestive skin or bone localizations. Fifteen patients recovered without sequelae and one died as a result of S. aureus septicopyemia. In view of the patterns of resistance to antimicrobial agents exhibited by S. aureus and S. epidermidis, the vancomycin-amikacin combination seems the most appropriate treatment in neonatal staphylococcal septicemias. However, the fosfomycin-cefotaxim combination can be proposed for the treatment of staphylococcal infections with osteoarticular or meningeal involvement.
authors.affiliation: Service de Pédiatrie, Centre Hospitalier Régional et Universitaire, Dijon.
authors.forename: J B
authors.initials: JB
authors.lastname: Gouyon
authors.forename: C
authors.initials: C
authors.lastname: François
authors.forename: D
authors.initials: D
authors.lastname: Semama
authors.forename: D
authors.initials: D
authors.lastname: Sandre
authors.forename: J M
authors.initials: JM
authors.lastname: Duez
authors.forename: H
authors.initials: H
authors.lastname: Portier
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Septicémies nosocomiales à staphylocoques epidermidis et aureus chez le nouveau-né.