Glycerophospholipids and cholesterol composition of bile in bile-fistula rats treated with monensin.
Data regarding the action of monensin on the concentrations of glycerophospholipids and cholesterol in bile of rats subjected to total biliary diversion for 3 h are reported. After monensin their concentration in bile drops significantly in the first 60 min collections with respect to the control. Differences seem to be produced between the rates of transport to the bile of glycerophospholipids and cholesterol, not sufficiently explained by the inhibition of bile salt uptake determined by monensin at the sinusoidal pole of the hepatocyte.
Casu
A
A
Institute of General Pathology, University of Genoa, Italy.
Camogliano
L
L
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001652:Bile Ducts / Q000502:physiology* / Q000601:surgery; D001658:Biliary Fistula; D001692:Biological Transport / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008985:Monensin / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010712:Phosphatidic Acids; D008985:Monensin; D002784:Cholesterol