[The effect of ferromagnet particles on the growth of Walker carcinosarcoma 256 in Wistar rats].
The intravenous injection of ferromagnetic particles (FMP) was studied for its effect on the growth of Walker 256 carcinosarcoma in Wistar rats. The injection of FMP in a dose of 750 mg/kg increased the organism resistance to the tumour development against a background of phagocytic reaction activation in neutrophils. The injection of FMP in a dose up to 2 g/kg inhibited the phagocytic reactions of neutrophils and accelerated the tumour growth. The data obtained evidence that depending on the FMP dose the total reactivity of the organism may either increase or decrease, thus changing, respectively, its resistance to the development of the tumour process.
Volkonskiĭ
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D000818:Animals; D002279:Carcinoma 256, Walker / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004354:Drug Screening Assays, Antitumor; D005290:Ferric Compounds / Q000627:therapeutic use*; D059346:Magnets; D008297:Male; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010316:Particle Size; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D051381:Rats
D004337:Drug Carriers; D005290:Ferric Compounds; C001215:ferrite
Vliianie ferromagnitnykh chastits na rost kartsinosarkomy Uoker 256 u krys Wistar.