title: Statistical significance of some complex nucleotide combinations: a comparison of DNA models.
abstract: DNA is modelled as a sequence of nucleotide runs. This model is shown to provide a more adequate description of the observed frequencies of occurrence of local homopurine-homopyrimidine mirror repeats than the second-order homogeneous Markov chain model. The procedure is described for estimating the statistical significance of the occurrence of some complex nucleotide combinations in DNA.
authors.affiliation: Institute of Molecular Genetics, USSR Academy of Sciences, Moscow.
authors.forename: G M
authors.initials: GM
authors.lastname: Suboch
authors.lastname: Sprizhitsky YuA
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D004247:DNA; D008390:Markov Chains; D015233:Models, Statistical; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004247:DNA