title: Radiation injury to the temporal bone.
abstract: Osteoradionecrosis of the temporal bone is an unusual sequela of radiation therapy to the head and neck. Symptoms occur many years after the radiation is administered, and progression of the disease is insidious. Hearing loss (sensorineural, conductive, or mixed), otalgia, otorrhea, and even gross tissue extrusion herald this condition. Later, intracranial complications such as meningitis, temporal lobe or cerebellar abscess, and cranial neuropathies may occur. Reported here are five cases of this rare malady representing varying degrees of the disease process. They include a case of radiation-induced necrosis of the tympanic ring with persistent squamous debris in the external auditory canal and middle ear. Another case demonstrates the progression of radiation otitis media to mastoiditis with bony sequestration. Further progression of the disease process is seen in a third case that evolved into multiple cranial neuropathies from skull base destruction. Treatment includes systemic antibiotics, local wound care, and debridement in cases of localized tissue involvement. More extensive debridement with removal of sequestrations, abscess drainage, reconstruction with vascularized tissue from regional flaps, and mastoid obliteration may be warranted for severe cases. Hyperbaric oxygen therapy has provided limited benefit.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, New York Eye and Ear Infirmary/New York Medical College 10003.
authors.forename: R A
authors.initials: RA
authors.lastname: Guida
authors.forename: D G
authors.initials: DG
authors.lastname: Finn
authors.forename: I H
authors.initials: IH
authors.lastname: Buchalter
authors.forename: K H
authors.initials: KH
authors.lastname: Brookler
authors.forename: C P
authors.initials: CP
authors.lastname: Kimmelman
mesh_terms: D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D011832:Radiation Injuries / Q000503:physiopathology*; D012307:Risk Factors; D013701:Temporal Bone / Q000528:radiation effects; D013997:Time Factors