title: Surface hydrophobicity of gastric mucosa in peptic ulcer disease. Relationship to gastritis and Campylobacter pylori infection.
abstract: The hydrophobicity of biopsy specimens of gastric mucosa in 228 dyspeptic subjects undergoing diagnostic endoscopy was assessed by measuring the plateau-advancing contact angle of saline drops using a goniometer. Subjects with duodenal ulcers (n = 49) and gastric ulcers (n = 17) had significantly lower mean contact angles than controls (n = 124) without ulcer (57 degrees in duodenal ulcer, 59 degrees in gastric ulcer vs. 66 degrees in controls; p less than 0.0001). There was no change in contact angle after healing with H2-receptor antagonists by comparison with pretreatment (59 degrees vs. 56 degrees for duodenal ulcer, n = 15; 57 degrees vs. 59 degrees for gastric ulcer, n = 5). Controls with gastritis had lower contact angles than those without (61 degrees, n = 50, vs. 70 degrees, n = 63; p less than 0.0001). The presence of Campylobacter pylori was associated with a significant decrease in contact angle in controls (59 degrees, n = 39, vs. 70 degrees, n = 75; p less than 0.0001).
authors.affiliation: Department of Medicine, St. George's Hospital Medical School, Tooting, London, England.
authors.forename: R T
authors.initials: RT
authors.lastname: Spychal
authors.forename: P M
authors.initials: PM
authors.lastname: Goggin
authors.forename: J M
authors.initials: JM
authors.lastname: Marrero
authors.forename: S H
authors.initials: SH
authors.lastname: Saverymuttu
authors.forename: C W
authors.initials: CW
authors.lastname: Yu
authors.forename: C M
authors.initials: CM
authors.lastname: Corbishley
authors.forename: J D
authors.initials: JD
authors.lastname: Maxwell
authors.forename: T C
authors.initials: TC
authors.lastname: Northfield
mesh_terms: D001706:Biopsy; D002169:Campylobacter Infections / Q000473:pathology*; D004381:Duodenal Ulcer / Q000473:pathology*; D004415:Dyspepsia / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D011706:Pyloric Antrum; D013276:Stomach Ulcer / Q000473:pathology*; D013499:Surface Properties