title: Optimization of gradient-echo imaging parameters for intracaval filters and trapped thromboemboli.
abstract: Flow-phantom magnetic resonance (MR) gradient-echo (GRE) imaging at 1.5 T was performed on a titanium Greenfield filter containing trapped blood clots with a high concentration of either deoxyhemoglobin (DHb) or methemoglobin (MHb), simulating acute and older thromboemboli, respectively. Flip angle, repetition time (TR), and echo time (TE) were varied, and a contrast-to-noise ratio between trapped clots and flowing fluid (clot-flow contrast) was determined for each set of imaging parameters. Use of very low flip angles (less than or equal to 10 degrees) rendered MHb clots indistinguishable from flowing fluid. In general, DHb clots displayed greater clot-flow contrast than MHb clots regardless of flip angle. With increasing TE values, T2* effect was observed with MHb clots, and magnetic susceptibility artifacts increased. Overall, optimum clot-flow contrast for imaging of both DHb and MHb clots was achieved with a flip angle of 45 degrees-60 degrees, a TR of 50 msec, and the shortest TE possible. Using GRE parameters similar to the optimum parameters determined in vitro, the authors imaged four patients with nickel-titanium Simon filters and one dog with a titanium Greenfield filter. MR imaging was successful in demonstrating filter location, caval patency, and the presence and extent of intraluminal thrombus.
authors.affiliation: Department of Radiology, Georgetown University Hospital, Washington, DC.
authors.forename: G P
authors.initials: GP
authors.lastname: Teitelbaum
authors.forename: H V
authors.initials: HV
authors.lastname: Ortega
authors.forename: S
authors.initials: S
authors.lastname: Vinitski
authors.forename: R A
authors.initials: RA
authors.lastname: Clark
authors.forename: A T
authors.initials: AT
authors.lastname: Watanabe
authors.forename: A H
authors.initials: AH
authors.lastname: Matsumoto
authors.forename: M D
authors.initials: MD
authors.lastname: Rifkin
authors.forename: K H
authors.initials: KH
authors.lastname: Barth
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005374:Filtration / Q000295:instrumentation*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D008875:Middle Aged; D008961:Models, Structural; D013923:Thromboembolism / Q000175:diagnosis* / Q000378:metabolism; D013997:Time Factors; D014682:Vena Cava, Inferior
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin; D008706:Methemoglobin