[Regulation of antibody production by monokines and glucocorticoids].
The antibody production by B lymphocytes is regulated by a number of interleukins produced by T lymphocytes and/or monocytic cells: IL-1, IL-2, IL-4, IL-5, IL-6 and interferons. This response is also under the influence of other mediators such a glucocorticosteroid hormones. The in vivo administration of pharmacological doses of steroids do not markedly suppress the in vivo antibody response to exogeneous antigens. This is due to a contrasting effect: they prefoundly inhibit the production of most interleukins whereas they directly stimulate B lymphocyte response. We recently analyzed the mechanisms of this latter phenomenon and showed that glucocorticosteroids synergize with the monocyte-derived cytokines IL-1 and IL-6 to potentiate the in vitro B lymphocyte differentiation.
Galanaud
P
P
INSERM Unité 131, Clamart, France.
Emilie
D
D
D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D004357:Drug Synergism; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D015846:Monokines / Q000494:pharmacology*
D005938:Glucocorticoids; D007375:Interleukin-1; D015850:Interleukin-6; D015846:Monokines
Régulation de la production des anticorps par les monokines et les glucocorticoïdes.