[An experimental study of the psychotropic effects of aspartic acid from the aspect of age].
After acute injections to adult and 90-day old rats aspartic acid in doses of 100-500 mg/kg increased the locomotor and exploratory activity during the open-field test and in a dose of 100 mg/kg exerted the antidepressant effect during the forced swimming test. Following treatment for 10 days the amino acid in a dose of 10 mg/kg disrupted acquisition of passive avoidance reaction of young rats and in a dose of 100 mg/kg inhibited learning of active avoidance reaction in adult rats.
Kovalev
G V
GV
Sazhin
V A
VA
Skazkina
T G
TG
Ianitskaia
A V
AV
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011603:Psychophysiology; D011619:Psychotropic Drugs; D051381:Rats
D011619:Psychotropic Drugs; D001224:Aspartic Acid
Eksperimental'noe izuchenie psikhotropnykh éffektov asparaginovoĭ kisloty v vozrastnom aspekte.