The relationship of class I MHC antigen expression to stage IV-S disease and survival in neuroblastoma.
Cultured human neuroblastoma cells express low levels of class I (MHC) surface antigen. In order to determine if this low expression is representative of the clinical tumor, this study investigates class I expression in archival human neuroblastoma. Whereas stages I to IV neuroblastoma expressed low levels of class I antigen, stage IV-S tumor cells expressed normal levels, similar to control tissues. Expression of class I antigen in tumors from survivors of stage III neuroblastoma was significantly greater than in tumors from nonsurvivors. Tumors comprised predominantly of ganglion cells expressed significantly more class I antigen than neuroblasts. These data suggest that class I MHC expression may play a role in the natural history of human neuroblastoma.
Squire
R
R
Department of Pediatric Surgery, Children's Hospital, State University of New York, Buffalo 14222.
Fowler
C L
CL
Brooks
S P
SP
Rich
G A
GA
Cooney
D R
DR
D000704:Analysis of Variance; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005434:Flow Cytometry; D005729:Ganglioneuroma / Q000276:immunology* / Q000473:pathology; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000276:immunology* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I