Algorithm for short-term prescription of phenprocoumon.
Data from the start of anticoagulation therapy using the coumarin derivative phenprocoumon were obtained retrospectively for 101 patients, and the correct long-term maintenance dose (MD) of the drug was determined. The average loading dose was 23.2 +/- 7.8 mg and the average MD 2.14 +/- 0.99 mg. The physician's prescription on discharge tended to underestimate the true MD by 0.29 +/- 0.64 mg. Significant positive correlations with MD were noted for loading dose and weight and negative correlations for age, serum creatinine, initial prothrombin ratio, and length of treatment pause (days) for patients receiving an excessive loading dose. Using stepwise variance analysis, an algorithm was obtained that predicted the MD: MD = -0.7 + loading dose/10 - treatment pause/7 - age/60 + initial prothrombin ratio. The accuracy (0.02 +/- 0.54 mg) was similar to that of the discharging physician. The algorithm required an average observation period of 5.4 days and the physician's estimate 12.4 days. It is suggested that the use of the algorithm would lead to shorter hospitalization without loss of treatment accuracy.
Heaf
J
J
Department of Medicine B, Centralsygehuset, Hillerød, Denmark.
Guldager
B
B
D015110:4-Hydroxycoumarins / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003627:Data Interpretation, Statistical; D011307:Drug Prescriptions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000008:administration & dosage*; D011516:Prothrombin / Q000032:analysis
D015110:4-Hydroxycoumarins; D011516:Prothrombin; D010644:Phenprocoumon