Histocompatibility antigens (A, B, C, and DR) in Arabs with rheumatoid arthritis.
Eighty-five Arab patients in Kuwait with classical and definite rheumatoid arthritis were typed to examine the frequency of HLA-A, B, C, and DR antigens. The results showed a significant increase in the frequency of HLA-A10, B8, B21, and DR3 antigens when compared to an age- and sex-matched control population. HLA-DR3 was present in 34 per cent of the patients compared with 2 per cent of the controls (p less than 0.001). The association of RA in the Arab population with HLA-DR3 rather than HLA-DR4 or HLA-DR1 as reported in other ethnic groups emphasizes further the complexity of the genetics of RA.
Sattar
M A
MA
Department of Medicine, Faculty of Medicine, Kuwait University, Safat.
al-Saffar
M
M
Guindi
R T
RT
Sugathan
T N
TN
White
A G
AG
Behbehani
K
K
D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D015415:Biomarkers; D004198:Disease Susceptibility; D005006:Ethnicity; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007730:Kuwait
D015415:Biomarkers; D006680:HLA Antigens