Embryotoxic evaluation of bis(tri-n-butyltin)oxide (TBTO) in mice.
Pregnant mice were treated on days 6-15 of gestation with 5, 20 and 40 mg/kg/d bis(tri-n-butyltin)oxide (TBTO), and sacrificed on gestational day 17. At the highest dose TBTO caused a significant reduction of maternal body weight gain and also proved to be highly embryotoxic. Necropsy showed a dose-related decrease in spleen weight while a dose-dependent increase in placental weight was observed.
Baroncelli
S
S
Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.
Karrer
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D
Turillazzi
P G
PG
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005327:Fetal Resorption / Q000139:chemically induced*; D005865:Gestational Age; D008098:Litter Size / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000633:toxicity*
D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide