Effect of superior vena caval hypertension on alloxan-induced lung injury in dogs.
To investigate how fast and to what extent superior vena caval hypertension (SVCH) increases lung water in acute increased-permeability state, we studied the time course of lung water accumulation for 3 h in anesthetized dogs under different treatments: 1) controls without intervention (5 dogs), 2) SVCH alone (5 dogs), 3) mild lung microvascular injury induced by low-dose alloxan (75 mg/kg) alone (5 dogs), and 4) SVCH coupled with low-dose alloxan (5 dogs). Neither low-dose alloxan alone nor SVCH alone [superior vena caval pressure (Psvc) = 11.0 +/- 3.1 (SD) mmHg] increased lung water significantly. The SVCH coupled with low-dose alloxan (Psvc = 11.3 +/- 2.7 mmHg) doubled extravascular lung thermal volume measured by the thermal-dye dilution technique within 1 h (5.3 +/- 0.9 ml/kg at base line and 10.9 +/- 4.7 ml/kg at 1 h), then remained unchanged (12.5 +/- 5.7 ml/kg at 3 h). This increase in lung water was confirmed by gravimetric method (5.69 +/- 1.71 g/g blood-free dry wt). We conclude that SVCH is one of the factors that may promote lung water accumulation in increased-permeability state.
Ando
F
F
Second Department of Internal Medicine, School of Medicine, Gifu University, Japan.
Arakawa
M
M
Kambara
K
K
Miyazaki
H
H
Segawa
T
T
Hirakawa
S
S
D000496:Alloxan / Q000009:adverse effects*; D000818:Animals; D004285:Dogs; D015633:Extravascular Lung Water / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology*; D008168:Lung / Q000187:drug effects; D055370:Lung Injury; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology; D013479:Superior Vena Cava Syndrome / Q000503:physiopathology*
D000496:Alloxan