title: Interstitial laser phototherapy assisted by magnetic resonance imaging: a new technique for monitoring laser-tissue interaction.
abstract: The rapid technological advances of magnetic resonance imaging, laser fiberoptics, and compatible probes may allow treatment of deep and sometimes surgically unreachable tumors of the head and neck with minimal morbidity through interstitial laser phototherapy. In this study, a new application of magnetic resonance imaging was developed to monitor and quantify laser-induced tissue damages. Pig skin was exposed to increased levels of argon laser (514.5 nm) at energy densities between 62.5 and 375 J/cm2 as determined by an accurate and reproducible method of dosimetry. Thermal profiles were recorded using an infrared sensor and T1- and T2-weighted magnetic resonance images were taken; afterward, biopsies were performed to quantitate the level of tissue damage. Our results demonstrate that above a certain threshold of laser energy, the magnetic resonance imaging findings are temperature dependent. Appropriate development of a scale matching laser energies, temperature profiles, T1- and T2-weighted magnetic resonance images, and histological quantitation of tissue destruction will allow us to optimize the three-dimensional control and monitoring of laser-tissue interactions.
authors.affiliation: Division of Head and Neck Surgery, University of California, Los Angeles, School of Medicine.
authors.forename: D J
authors.initials: DJ
authors.lastname: Castro
authors.forename: R E
authors.initials: RE
authors.lastname: Saxton
authors.forename: L J
authors.initials: LJ
authors.lastname: Layfield
authors.forename: H R
authors.initials: HR
authors.lastname: Fetterman
authors.forename: D J
authors.initials: DJ
authors.lastname: Castro
authors.forename: P B
authors.initials: PB
authors.lastname: Tartell
authors.forename: J D
authors.initials: JD
authors.lastname: Robinson
authors.forename: S Y
authors.initials: SY
authors.lastname: To
authors.forename: E
authors.initials: E
authors.lastname: Nishimura
authors.forename: R B
authors.initials: RB
authors.lastname: Lufkin
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007834:Lasers; D008279:Magnetic Resonance Imaging; D008991:Monitoring, Physiologic / Q000379:methods; D010789:Phototherapy; D012867:Skin / Q000528:radiation effects; D013552:Swine