Post mortem kinetics of secobarbital.
Post-mortem changes in barbiturate concentrations were evidenced using a rat-secobarbital model. The method used for the extraction and HPLC assay of barbiturates is suitable for all biologic fluids and post-mortem tissues. Kinetic data obtained is of excellent quality. Various modelization constants were defined. This experimental work emphasizes the difficulty of post-mortem toxicology, as concentrations found at the time of autopsy may be different from concentrations at the time of death, in blood as well as in tissues.
Quatrehomme
G
G
Laboratoire de Médecine Légale, Faculté de Medecine, Nice, France.
Bourret
F
F
Zhioua
M
M
Lapalus
P
P
Ollier
A
A
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D011180:Postmortem Changes; D051381:Rats; D011919:Rats, Inbred Strains; D012631:Secobarbital / Q000493:pharmacokinetics*
D012631:Secobarbital