title: Influence of corticosterone on tracheal mucociliary transport in pigeons.
abstract: The effects of corticosteroids on tracheal mucociliary transport (MCT) were examined in pigeons. Intramuscular administration of corticosterone had no effect at 1.0 mg/kg, while at a larger dose of 5.0 mg/kg, it slightly, but significantly increased the MCT rate. Metyrapone significantly decreased the MCT rate, and the inhibitory action was blocked by 1.0 mg/kg corticosterone. The present study suggested that corticosteroids modulated the mucociliary clearance, especially under some diseases associated with a decreased level of endogenous corticosteroids.
authors.affiliation: Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kai
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Takahama
authors.forename: T
authors.initials: T
authors.lastname: Miyata
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D010856:Columbidae / Q000502:physiology*; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D008797:Metyrapone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
chemical_list: D003345:Corticosterone; D008797:Metyrapone