title: Effects of manganese and other divalent cations on progressive motility of human sperm.
abstract: Manganese (Mn2+) stimulated the progressive motility of human washed sperm in a time- and dose-dependent manner. This confirmed previous data indicating a capacity for activating the adenylyl cyclase of sperm homogenates in vitro. A maintained response was best seen with doses 0.2-1.0 mM. After an initial stimulation, higher concentrations of up to 20 mM were associated with a decline in the response to control levels. Magnesium ions (Mg2+) stimulated motility in the same dose range but to less than 50% of the Mn2+ response. Other divalent cations such as zinc (Zn2+), strontium (Sr2+), and Calcium (Ca2+) also exerted stimulatory effects to varying degrees in descending order. Metal ion effects on sperm motility may be mediated through a common cation-binding site on the adenylyl cyclase.
authors.affiliation: Department of Gynecology and Obstetrics, National Hospital, Oslo, Norway.
authors.forename: O
authors.initials: O
authors.lastname: Magnus
authors.forename: I
authors.initials: I
authors.lastname: Brekke
authors.forename: T
authors.initials: T
authors.lastname: Abyholm
authors.forename: K
authors.initials: K
authors.lastname: Purvis
mesh_terms: D002413:Cations, Divalent / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D002413:Cations, Divalent; D008345:Manganese