title: Diminished submandibular salivary flow in dementia of the Alzheimer type.
abstract: Dementia of the Alzheimer Type (DAT) is the most common type of dementia among the elderly. Alzheimer's disease is a major public health problem, yet little is known about the potential oral consequences of the disease. Because saliva is believed to be essential for the preservation of oral health and function, salivary gland fluid output was evaluated in a population of essentially healthy patients with early-stage DAT. Unstimulated and stimulated parotid and submandibular salivary gland secretions were collected from 28 nonmedicated and otherwise healthy DAT patients, and 35 age-matched healthy controls. Submandibular saliva flow rates were significantly lower among the patients with DAT compared to controls, while parotid flow rates did not differ. The results suggest a selective impairment in submandibular gland function in essentially healthy patients with early-stage DAT.
authors.affiliation: National Institute of Dental Research, NIH, Bethesda, MD 20892.
authors.forename: J A
authors.initials: JA
authors.lastname: Ship
authors.forename: C
authors.initials: C
authors.lastname: DeCarli
authors.forename: R P
authors.initials: RP
authors.lastname: Friedland
authors.forename: B J
authors.initials: BJ
authors.lastname: Baum
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010306:Parotid Gland / Q000378:metabolism; D011336:Probability; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate; D013363:Submandibular Gland / Q000378:metabolism*
chemical_list: D002951:Citrates; D019343:Citric Acid