Failure to find interference between anti-HLA antibodies and chlorpromazine.
Chlorpromazine has been reported to interfere with the action of alloantibodies directed against HLA-A1. We attempted to replicate this finding using peripheral blood lymphocytes from 3 healthy donors in a complement-mediated lymphocytotoxicity assay. We were unable to find evidence of interference between chlorpromazine and the anti-HLA sera tested. Possible reasons for the difference between our finding and the previous report, as well as the implications for schizophrenia, are discussed.
Alexander
R C
RC
Neuropsychiatry Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032.
Coggiano
M A
MA
Wyatt
R J
RJ
D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015788:HLA-A1 Antigen / Q000276:immunology*; D015795:HLA-B8 Antigen / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D007518:Isoantibodies; D002746:Chlorpromazine