[Prolonging transplant survival time by PUVA treatment of the transplant recipient. Significance of cis-urocanic acid].
A PUVA treatment of the recipients of murine tail skin grafts led to a significant prolongation of transplant survival. A possible mechanism of the systemic immunomodulatory effects of ultraviolet light in the organism is the transformation of urocanic acid in the skin from its trans- to the cis-isomer, which acts as a mediator on the immune system. A treatment of graft recipients with cis-, but not trans-urocanic acid also prolonged graft survival. The rejection of secondary grafts and the humoral immune response of mice to sheep erythrocytes were not influenced by cis-urocanic acid. These results implicate that cis-urocanic acid may be get use in clinical organ transplantation and dermatology.
Gruner
S
S
Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin (Charité), Humboldt-Universität zu Berlin.
Stoppe
H
H
Eckert
R
R
Sönnichsen
N
N
Diezel
W
W
D000818:Animals; D006085:Graft Survival / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011701:PUVA Therapy / Q000379:methods*; D016038:Skin Transplantation / Q000276:immunology*; D014560:Urocanic Acid / Q000494:pharmacology*
D007093:Imidazoles; D014560:Urocanic Acid
Verlängerung der Transplantatüberlebenszeit durch eine PUVA-Behandlung des Transplantatempfängers. Bedeutung von cis-Urocaninsäure.