title: Rising incidence of breast cancer: relationship to stage and receptor status.
abstract: We used the population-based tumor registry of Kaiser Permanente in the United States (Portland, OR) to analyze breast cancer incidence from 1960 to 1985. Overall, incidence rose 45% during this period. The largest increases occurred in women 60 years of age or older (74%) and in those 45-59 (36%). The rate in women aged 20-44 has remained essentially unchanged. Localized and regional disease showed similar increases. Review of medical records revealed that only a small portion of this increase was likely to result from increased screening activities. From the increased availability of receptor assays in a large proportion of cases since the mid-1970s, we observed that incidence of estrogen receptor-negative cancers rose 22%-27% between the mid-1970s and the mid-1980s. In contrast, incidence of estrogen receptor-positive tumors increased an average of 131% in the same period, perhaps implicating hormonal factors in the rising incidence of breast cancer.
authors.affiliation: Center for Health Research, Kaiser Permanente, Portland, OR.
authors.forename: A G
authors.initials: AG
authors.lastname: Glass
authors.forename: R N
authors.initials: RN
authors.lastname: Hoover
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis*; D012042:Registries; D015996:Survival Rate; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: D011960:Receptors, Estrogen