Age-related cholinergic drug effects on analgesia in two inbred strains of mice.
The two inbred strains of mice C57BL/6 and DBA/2 are characterized by a different behavioral reactivity to cholinergic agents during development. The present experiment revealed that the strain-dependent differences in cholinergic-mediated analgesia during development disappeared during adult life. In fact, oxotremorine administration (0.0025 and 0.005 mg/kg) exerted the same analgesic effect in both strains at 6 months of age, in contrast with the finding of the lack of any effect of the drug in C57 mice at two months of age in comparison with DBA.
Fagioli
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S
Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Rome, Italy.
Consorti
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D
Pavone
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F
D000375:Aging / Q000378:metabolism*; D000698:Analgesia; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D008811:Mice, Inbred DBA / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D010095:Oxotremorine / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology*
D010277:Parasympathomimetics; D010095:Oxotremorine; D012601:Scopolamine