title: Diagnostic fiberoptic bronchoscopy and protected brush culture in patients with community-acquired pneumonia.
abstract: A model for performing fiberoptic bronchoscopy as a supplement to noninvasive diagnostic methods, in patients with community-acquired pneumonia, was prospectively studied. Twenty-four patients underwent bronchoscopy, seven pilot patients and 17 of 277 (6 percent) consecutive patients with CAP. Indications for FOB were early therapy failure (less than or equal to 72h)(n = 7), late therapy failure (greater than 72h)(n = 11), or before start of antibiotic therapy in severely ill or immunocompromised patients (n = 6). Samples were obtained by aspiration of bronchial secretion and with a protected brush catheter from which quantitative cultures with a detection level of 10(4) colony forming units per ml were performed. Results concluded that FOB, with the use of quantitative PB-cultures, offered a safe and specific diagnostic tool, which on special indications, can be of great value in the management of patients with CAP.
authors.affiliation: Department of Infectious Diseases, Karolinska Institute, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ortqvist
authors.forename: M
authors.initials: M
authors.lastname: Kalin
authors.forename: L
authors.initials: L
authors.lastname: Lejdeborn
authors.forename: B
authors.initials: B
authors.lastname: Lundberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D020680:Bronchoscopes; D001999:Bronchoscopy / Q000379:methods*; D002406:Catheterization, Peripheral / Q000295:instrumentation*; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011014:Pneumonia / Q000175:diagnosis* / Q000382:microbiology; D011446:Prospective Studies; D013183:Sputum / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents