title: Isoniazid toxicity presenting as seizures and metabolic acidosis.
abstract: The presenting signs and symptoms of isoniazid toxicity are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces severe central nervous system symptoms that are rapidly reversed with intravenous administration of pyridoxine.
authors.affiliation: Department of Emergency Medicine, Howard University Hospital, Washington, DC 20060.
authors.forename: R C
authors.initials: RC
authors.lastname: Watkins
authors.forename: E L
authors.initials: EL
authors.lastname: Hambrick
authors.forename: G
authors.initials: G
authors.lastname: Benjamin
authors.forename: S N
authors.initials: SN
authors.lastname: Chavda
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy; D000293:Adolescent; D006801:Humans; D007262:Infusions, Intravenous; D007538:Isoniazid / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D011736:Pyridoxine; D007538:Isoniazid