title: Serum activity that confers acid lability to alpha-interferon in systemic lupus erythematosus: its association with disease activity and its independence from circulating alpha-interferon.
abstract: We conducted a longitudinal evaluation of a patient with systemic lupus erythematosus who constitutively exhibited elevated levels of circulating alpha-interferon (alpha-IFN). This study demonstrated that the serum levels of an activity that renders the endogenous alpha-IFN acid labile are positively correlated with disease activity. This IFN acid lability-inducing activity can also be found in the sera of systemic lupus erythematosus patients who have active disease but who do not have circulating alpha-IFN.
authors.affiliation: Department of Microbiology, New York University School of Medicine, New York.
authors.forename: A M
authors.initials: AM
authors.lastname: Yee
authors.forename: Y K
authors.initials: YK
authors.lastname: Yip
authors.forename: H D
authors.initials: HD
authors.lastname: Fischer
authors.forename: J P
authors.initials: JP
authors.lastname: Buyon
mesh_terms: D000143:Acids; D000328:Adult; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology
chemical_list: D000143:Acids; D007370:Interferon Type I