Neuroblastoma in a patient with Sotos' syndrome.
Sotos' syndrome, or cerebral gigantism, is a disorder of growth regulation. Tumours have occasionally been reported in children with Sotos' syndrome, but it is uncertain whether this is a coincidence, or whether it is aetiologically related to the underlying disorder of growth. We report a 15 month old child with a paraspinal neuroblastoma and Sotos' syndrome and suggest that children with this condition may be at higher risk for developing tumours than the general population.
Nance
M A
MA
Department of Pediatrics, University of Minnesota, Minneapolis 55455.
Neglia
J P
JP
Talwar
D
D
Berry
S A
SA
D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D005877:Gigantism / Q000150:complications*; D006130:Growth Disorders / Q000150:complications*; D006801:Humans; D006972:Hypertelorism; D007223:Infant; D009447:Neuroblastoma / Q000175:diagnosis / Q000209:etiology*; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome