New methods to detect the effect of alteration in gastric pH and intestinal transit by metoclopramide and propantheline using a continuous gastric pH probe and hydrogen breath analysis.
The effects of oral doses of metoclopramide (M, 10 mg) and propantheline (P, 30 mg) on alteration in gastric pH and emptying were determined using a continuous pH probe (Digitrapper, Synectics) and hydrogen breath analysis (HBA, QuinTron) in eight male subjects. The four phases consisted of HBA, HBA and pH probe, and HBA and pH probe and either P or M. Baseline pH measurements were recorded for 60 min prior to dosing with 10 g of lactulose in three of the periods. Dosing with P or M was given 30 min before administration of lactulose. HBA and continuous gastric pH were measured for 120 min. M produced earlier and higher peak hydrogen concentration than control (p less than 0.0001). P decreased peak hydrogen and increased gastric pH from approximately 2.0 to 4.0 (p less than 0.0001).


CONCLUSIONS
1) HBA can be used to detect alterations of intestinal motility; 2) The gastric pH probe produces a small increase in intestinal motility; and 3) The combination of the gastric pH probe and HBA could be a useful technique to simultaneously evaluate gastric pH and gastrointestinal motility.
Hughes
G S
GS
Upjohn Company, Upjohn Research Clinics, Kalamazoo, MI.
VanderLugt
J T
JT
Bays
M
M
Bohan
D F
DF
Francom
S F
SF
D000328:Adult; D001944:Breath Tests; D005744:Gastric Acid / Q000502:physiology*; D005745:Gastric Acidity Determination; D005769:Gastrointestinal Motility / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011413:Propantheline / Q000494:pharmacology*; D011897:Random Allocation
D011413:Propantheline; D006859:Hydrogen; D008787:Metoclopramide