Monosomy 3 and isochromosome 8q in a uveal melanoma.
Chromosome analysis of a locally invasive uveal melanoma revealed monosomy 3 and i(8q). Sublines with multiple copies of the i(8q) were also present. Loss of heterozygosity for genes on chromosome 3 and duplication of genes on 8q may play an important role in progression of uveal melanoma.
Horsman
D E
DE
Department of Pathology, Vancouver General Hospital, B. C., Canada.
Sroka
H
H
Rootman
J
J
White
V A
VA
D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D005810:Multigene Family; D014604:Uveal Neoplasms / Q000235:genetics*