Serum activity that confers acid lability to alpha-interferon in systemic lupus erythematosus: its association with disease activity and its independence from circulating alpha-interferon.
We conducted a longitudinal evaluation of a patient with systemic lupus erythematosus who constitutively exhibited elevated levels of circulating alpha-interferon (alpha-IFN). This study demonstrated that the serum levels of an activity that renders the endogenous alpha-IFN acid labile are positively correlated with disease activity. This IFN acid lability-inducing activity can also be found in the sera of systemic lupus erythematosus patients who have active disease but who do not have circulating alpha-IFN.
Yee
A M
AM
Department of Microbiology, New York University School of Medicine, New York.
Yip
Y K
YK
Fischer
H D
HD
Buyon
J P
JP
D000143:Acids; D000328:Adult; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000473:pathology
D000143:Acids; D007370:Interferon Type I