title: Tracheobronchial mucociliary clearance and alveolar epithelial permeability measured by PET with 18FDG powder.
abstract: Tracheobronchial mucociliary clearance and alveolar permeability were measured with positron emission tomography using a water-soluble dry aerosol, sodium-N-acetyl-neuraminate tagged with 2-deoxy-2-[18F]fluoro-D-glucose (18FDG powder). Five normal volunteers inhaled 1.5-2.0 mCi of FDG powder by a single deep breath. The distribution of radioactivity, measured by scanning during a period of 120 min, showed that the 18FDG powder deposition progressed from the central airways to the peripheral alveolar areas. In the tracheobronchial system the radioactivity decreased to 24% of the initial deposition at 60 min. In the peripheral alveolar area, where absorption into blood or lymphatic flow crossing the epithelial layer represents a unique mechanism of clearance for water-soluble 18FDG powder, alveolar radioactivity decreased slowly to approximately 70% of the initial deposition at 60 min after inhalation. Positron emission tomography using 18FDG powder provides a regional evaluation of both mucociliary transport in the tracheobronchial system and epithelial permeability in the alveolar area.
authors.affiliation: Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Hatazawa
authors.forename: M
authors.initials: M
authors.lastname: Yanai
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: F
authors.initials: F
authors.lastname: Ojima
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Aikawa
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Takishima
authors.forename: S
authors.initials: S
authors.lastname: Watanuki
mesh_terms: D000042:Absorption; D000328:Adult; D001980:Bronchi / Q000378:metabolism; D003837:Deoxy Sugars; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004848:Epithelium / Q000378:metabolism; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D010539:Permeability; D011650:Pulmonary Alveoli / Q000378:metabolism; D012016:Reference Values; D012137:Respiratory System / Q000378:metabolism*; D014055:Tomography, Emission-Computed; D014132:Trachea / Q000378:metabolism
chemical_list: D003837:Deoxy Sugars; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose