HLA and celiac disease in Argentina: involvement of the DQ subregion.
A population of 62 unrelated homogeneous Argentinian celiac pediatric patients were typed for HLA-A,B,C,DR, and DQ antigens. The association between celiac disease and the DR3 and DR7 antigens was confirmed. The specificity DQw2 was present in 95.2 per cent of the patients. Nevertheless, it was of interest that the most significant phenotypes observed were DR3/DR7, DR7/DR5, and DR3/DR5. The significance of these findings is discussed.
Palavecino
E A
EA
Laboratorio de Immunogenética, Hospital de Clinicas José de San Martin, Facultad de Medicina, U.B.A., Argentina.
Mota
A H
AH
Awad
J
J
Derosa
S
S
Herrera
M
M
Chertkoff
L
L
Satz
L
L
Fainboim
L
L
D000483:Alleles; D001118:Argentina; D015415:Biomarkers; D002446:Celiac Disease / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D002648:Child; D004198:Disease Susceptibility; D005006:Ethnicity; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007558:Italy / Q000208:ethnology; D008297:Male; D013030:Spain / Q000208:ethnology
D015415:Biomarkers; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens