title: [Treatment of acromegaly. Results in 56 patients].
abstract: The results of the treatment of acromegaly in 56 patients have been reviewed. Transsphenoidal pituitary adenomectomy (TPA) represented the most effective therapy, as it resulted in a cure rate of 64.7%, with 8.8% of complications and 14.7% of endocrine insufficiencies secondary to surgery. When radiotherapy was administered after surgery (when the latter had not been curative), the overall rate of cure increased to 73.5%. By contrast, the patients treated only with radiotherapy had a markedly lower cure rate (44.4%), with a higher rate of endocrine insufficiency (55%). The occurrence of extrasellar extension shown in preoperative pituitary computed tomography did not correlate with a worse postoperative cure rate; by contrast, the invasive character of the adenoma represented a reduction in the postoperative cure rate. It was concluded that TPA is the treatment of choice in acromegaly, independently of the tumor size.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, Barcelona.
authors.forename: C
authors.initials: C
authors.lastname: del Pozo
authors.forename: S M
authors.initials: SM
authors.lastname: Webb
authors.forename: B
authors.initials: B
authors.lastname: Oliver
authors.forename: P
authors.initials: P
authors.lastname: Tresserras
authors.forename: A
authors.initials: A
authors.lastname: de Leiva
mesh_terms: D000172:Acromegaly / Q000209:etiology / Q000628:therapy*; D000236:Adenoma / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000628:therapy*
vernacular_title: Tratamiento de la acromegalia. Resultados en 56 pacientes.