Chlorpromazine disposition in relation to age in children.
The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = -0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.
Furlanut
M
M
Department of Pharmacology, University of Padua, Italy.
Benetello
P
P
Baraldo
M
M
Zara
G
G
Montanari
G
G
Donzelli
F
F
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male
D002746:Chlorpromazine