title: Postoperative organic mental syndromes in lung transplant recipients. Toronto Lung Transplant Group.
abstract: Delirium and other organic mental syndromes have frequently complicated the postoperative course of lung transplant recipients. A retrospective survey of 30 single-lung, double-lung, and heart-lung transplantations was undertaken to investigate the frequency of postoperative delirium, the responsible causative factors, and the efficacy of management strategies. Seventy-three percent of all recipients demonstrated an episode of delirium during their first 2 postoperative weeks. Undergoing cardiopulmonary bypass, having higher cyclosporine levels, and moving one's home from a distant location to await surgery were associated with an increased risk of postoperative delirium. A protocol that uses the intravenous administration of haloperidol has proved both effective and safe in the management of this frequently problematic complication.
authors.affiliation: Toronto General Hospital, University of Toronto, Ontario, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Craven
mesh_terms: D000293:Adolescent; D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects; D003693:Delirium / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D016041:Heart-Lung Transplantation / Q000523:psychology; D006801:Humans; D016040:Lung Transplantation / Q000523:psychology; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D003524:Cyclosporins; D006220:Haloperidol