Monoclonal antibody HML-1, a marker for intraepithelial T cells and lymphomas derived thereof, also recognizes hairy cell leukemia and some B-cell lymphomas.
Current views regard monoclonal antibody HML-1 as an exquisite marker for intraepithelial T cells and primary intestinal and cutaneous T-cell lymphomas. We show that HML-1 reacted with 11 of 12 cases of hairy cell leukemia, with 1 of 13 cases of primary gastrointestinal B-cell lymphoma, and with an unclassified large-cell B lymphoma of the thoracic wall. We conclude that HML-1 is not restricted to the T-cell lineage and that the HML-1 antigen is expressed in a small subset of both T- and B-cell neoplasms.
Möller
P
P
Institute of Pathology, Heidelberg University, West Germany.
Mielke
B
B
Moldenhauer
G
G
D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology*; D001402:B-Lymphocytes / Q000032:analysis / Q000276:immunology / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis / Q000276:immunology*; D004848:Epithelium / Q000032:analysis / Q000276:immunology / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000032:analysis / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007943:Leukemia, Hairy Cell / Q000175:diagnosis / Q000276:immunology*; D008223:Lymphoma / Q000032:analysis / Q000175:diagnosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D013899:Thoracic Neoplasms / Q000032:analysis / Q000175:diagnosis / Q000276:immunology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor