title: A new system of treating wounds by a continuous topical application of medication.
abstract: A new procedure using a silicone gel sheet that enables the continuous topical application of a drug to a wound, and the effect of this therapeutic procedure on experimental skin flaps of rats, are described. Although a silicone gel sheet without a drug did not augment the flap survival length, silicone gel sheets containing Prostaglandin E1 (PGE1) and Ofloxacin showed significant elongation of the survival length of the flaps without signs of infection. Similarly, silicone gel sheets containing PGE1 inserted under the flap, like a drain, also showed statistically significant augmentation of the flap survival length. These facts showed a therapeutic potential of this new silicone gel sheet containing a drug.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Yotsuyanagi
authors.forename: I
authors.initials: I
authors.lastname: Hatayama
authors.forename: K
authors.initials: K
authors.lastname: Sone
mesh_terms: D000287:Administration, Topical; D000527:Alprostadil / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D001458:Bandages; D005260:Female; D005782:Gels; D006085:Graft Survival / Q000187:drug effects; D015242:Ofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D011140:Polyurethanes; D051381:Rats; D012828:Silicones; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps / Q000502:physiology*
chemical_list: D005782:Gels; C027324:Opsiture; D011140:Polyurethanes; D012828:Silicones; D015242:Ofloxacin; D000527:Alprostadil