Interleukin 1 beta modulates hepatic synthesis of alpha 1-acid glycoprotein in the fetal rat.
The ability of the fetal rat to respond to interleukin 1 beta (IL1 beta) by expressing alpha 1-acid glycoprotein (AGP) was investigated. Eight and 20 h after injection of 7 ng IL1 beta into 19-day fetuses, liver AGP mRNA increased by a factor of 66 and 82 respectively, while serum AGP levels increased by a factor of 3 and 5. Similar treatment of the mothers altered in the fetuses neither AGP serum levels nor the amount of liver AGP mRNA. The induction of AGP gene expression in the fetal liver in response to IL1 beta was similar to that observed in the adult liver. These results demonstrate that at day 19 the fetal rat liver has acquired a mature acute-phase system.
Durand
D
D
Laboratoire d'Endocrinologie, UFR des Sciences Pharmaceutiques, Université Paris V, France.
Bertaux
O
O
Fournier
T
T
Porquet
D
D
Valencia
R
R
Durand
G
G
D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus; D007375:Interleukin-1 / Q000097:blood / Q000235:genetics / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000096:biosynthesis*; D011247:Pregnancy; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology
D007375:Interleukin-1; D009961:Orosomucoid; D012333:RNA, Messenger; D011994:Recombinant Proteins