Determination of ivermectin residues in swine tissues--an improved clean-up procedure using solid-phase extraction.
A rapid and sensitive HPLC method has been developed for the determination of ivermectin in swine tissues. The clean-up procedure is based on solid-phase extraction on a Bond-Elut C8 cartridge. The average recovery from spiked swine muscle tissue was 87% in the concentration range 2-20 micrograms/kg. The method has a limit of detection of 0.5-1 microgram/kg. A survey of the levels in muscle tissues from 35 sanitary slaughtered sows was made. Five samples were found to contain ivermectin at concentrations between 3.4 and 27.6 micrograms/kg. A good correlation (r = 0.9696) was found between these results and those obtained using another established method.
Nordlander
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Nutrition Laboratory, National Food Administration, Uppsala, Sweden.
Johnsson
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H
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D007559:Ivermectin / Q000032:analysis*; D008460:Meat / Q000032:analysis; D009132:Muscles / Q000032:analysis; D010865:Pilot Projects; D013552:Swine
D007559:Ivermectin