title: Comparison of bone marrow histology in early chronic granulocytic leukemia and in leukemoid reaction.
abstract: A retrospective study was performed on bone marrow biopsies of 50 untreated patients with leukemoid reactions (LR) and 50 untreated patients with early chronic granulocytic leukemia (CGL). A comparison was made between hematopoietic and adipose tissues, bone and its cells, as well as other stromal components in these two disorders. Histologic and histomorphometric analyses revealed significant differences in trabecular structure, in localization of fat cells, in numbers of sinusoids, capillaries and various stromal elements. No significant differences between LR and CGL were detected in the quantity of erythro- and granulocytopoiesis and of megakaryocytes, but these were smaller in CGL than in LR. This histologic and histomorphometric evaluation demonstrates that certain histologic features may serve as valuable aids in distinguishing LR from CGL.
authors.affiliation: Institute of Pathology, University of Graz Medical School, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Schmid
authors.forename: B
authors.initials: B
authors.lastname: Frisch
authors.forename: A
authors.initials: A
authors.lastname: Beham
authors.forename: K
authors.initials: K
authors.lastname: Jäger
authors.forename: G
authors.initials: G
authors.lastname: Kettner
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006413:Hematopoietic System / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D007955:Leukemoid Reaction / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies