title: Plasma concentrations of cortisol, testosterone, glucose and blood gases in male goats during anaesthesia with pentobarbitone sodium.
abstract: Fasting for 24 h had no statistically significant effect on cortisol, glucose or testosterone concentrations. A dose of pentobarbitone sodium which induced light anaesthesia resulted in an immediate decrease in cortisol values from 5.0-11.1 ng/ml to 2.2-3.6 ng/ml until waking-this latter event was accompanied by an excessive release of cortisol (up to 16.6 ng/ml). In two out of three goats testosterone concentrations decreased from 4.0-9.0 ng/ml to less than 0.5 ng/ml after pentobarbitone; low values were maintained for 4.5-6 hours. Glucose concentrations were unaffected. Precise doses of pentobarbitone (20 mg/kg or 30 mg/kg) resulted in similar cortisol profiles as above but with higher concentrations achieved upon waking from the higher dose of pentobarbitone. On two out of nine occasions increased PCO2 values were recorded concurrently with increased cortisol concentrations during the period of anaesthesia, suggesting that a sufficiently strong stressful stimulus can break through the pentobarbitone blockade.
authors.affiliation: Department of Veterinary Clinical Science, University of Liverpool, Leahurst, Neston, South Wirral.
authors.forename: A A
authors.initials: AA
authors.lastname: Sanhouri
authors.forename: R S
authors.initials: RS
authors.lastname: Jones
authors.forename: H
authors.initials: H
authors.lastname: Dobson
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D006041:Goats / Q000097:blood*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010424:Pentobarbital; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D013739:Testosterone; D010424:Pentobarbital; D006854:Hydrocortisone