title: Reduction in Q wave myocardial infarctions with gemfibrozil in the Helsinki Heart Study.
abstract: The Helsinki Heart Study demonstrated a 34% (p less than 0.02) reduction in the incidence of cardiac end points (myocardial infarction and cardiac death) with the use of gemfibrozil compared with the use of a placebo in dyslipidemic middle-aged men. The major effect was confined to nonfatal myocardial infarctions. In this study we analyzed the effect of gemfibrozil therapy on the incidences of Q wave and non-Q wave infarctions, since the long-term prognoses of these two types of myocardial infarction may be different. The analyses indicated a 45% reduction (P less than 0.02, log-rank test) in the cumulative incidence of Q wave infarctions in the gemfibrozil group without a statistically significant effect on either the rate of non-Q wave infarctions or of coronary deaths. The reduction in the incidence of Q wave infarctions became evident during the second half of the 5-year study period.
authors.affiliation: First Department of Medicine, Helsinki University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Mänttäri
authors.forename: M
authors.initials: M
authors.lastname: Romo
authors.forename: V
authors.initials: V
authors.lastname: Manninen
authors.forename: P
authors.initials: P
authors.lastname: Koskinen
authors.forename: J K
authors.initials: JK
authors.lastname: Huttunen
authors.forename: O P
authors.initials: OP
authors.lastname: Heinonen
authors.forename: M H
authors.initials: MH
authors.lastname: Frick
mesh_terms: D003402:Creatine Kinase / Q000378:metabolism; D004311:Double-Blind Method; D004562:Electrocardiography; D015248:Gemfibrozil / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control*; D015996:Survival Rate
chemical_list: D003402:Creatine Kinase; D015248:Gemfibrozil