Early alterations of cochlear function in experimental perilymph fistulas.
Alterations of cochlear function secondary to perforation of the round window membrane in guinea pigs were expected to reveal sensitive and/or specific audiometric parameters in perilymph fistulas. A perforation of the round window membrane either did not affect acoustic compound action potential thresholds, or induced a delayed, possibly conductive, inner ear hearing loss. Also, evoked suprathreshold responses deteriorated progressively and independently of the increase of compound action potential thresholds. A sudden (conductive) hearing loss and a poor response to suprathreshold stimulation might indicate inner ear damage secondary to a perilymphatic fistula.
Böhmer
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ENT Department, University Hospital, Zurich, Switzerland.
D000818:Animals; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D001844:Bone Conduction; D003051:Cochlea / Q000503:physiopathology*; D003052:Cochlear Aqueduct / Q000503:physiopathology* / Q000601:surgery; D003055:Cochlear Microphonic Potentials; D004566:Electrodes; D005402:Fistula; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000502:physiology*; D010498:Perilymph / Q000502:physiology*; D012405:Round Window, Ear / Q000601:surgery; D012533:Scala Tympani / Q000503:physiopathology* / Q000601:surgery