Pharmacological activity of angiotensin-II modified by tyrosine sulfation.
An angiotensin-II analogue with a sulfated tyrosine residue was prepared by arylsulfotransferase treatment of synthetic human angiotensin-II. Its biological activities were studied in isolated smooth muscles, and its effect on blood pressure was determined. The sulfated angiotensin-II (AII-S) was about 15-30 fold less potent than angiotensin-II (AII) for ileum contraction and gallbladder contraction. The hypertensive potency of AII-S was about 30-fold less than that of AII.
Hagiwara
M
M
Fuji Chemical Industries, Ltd., Toyama, Japan.
Ohuchi
E
E
Hongo
K
K
Oki
M
M
Wada
K
K
Morikawa
T
T
Kobashi
K
K
D000804:Angiotensin II / Q000031:analogs & derivatives / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D015239:Arylsulfotransferase / Q000378:metabolism; D005704:Gallbladder / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D013431:Sulfates; D014443:Tyrosine / Q000031:analogs & derivatives*
D013431:Sulfates; D000804:Angiotensin II; D014443:Tyrosine; D015239:Arylsulfotransferase