[Surface-active properties of pulmonary surfactant and the functional activity of type II alveolocytes at various times of the day under experimental conditions].
Complex examination of lungs in 24 healthy guinea pigs in different periods of day using physicochemical, biochemical and electron-microscopic methods has revealed that the highest surface activity of the pulmonary surfactant (PS) is observed in the evening and at night, as phospholipids contain the highest amount of a surfactant of the phosphatidylcholine fraction the most active in the surface-active respect. An increase in the content of PS phospholipids in this period of the day appears to be a consequence of synthesis and secretion intensification in the second-type alveolocytes, that may be due to an increased effect of the vagus nerve.
Zagorul'ko
A K
AK
Birkun
A A
AA
Safronova
L G
LG
Kobozev
G V
GV
Gorelik
I I
II
D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D011663:Pulmonary Surfactants / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D013499:Surface Properties
D011663:Pulmonary Surfactants
Poverkhnostno-aktivnye svoĭstva surfaktanta legkikh i funktsional'naia aktivnost' al'veolotsitov II tipa v razlichnoe vremia sutok v éksperimente.