Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose.
We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.
Kolodzik
J M
JM
Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401-0927.
Eilers
M A
MA
Angelos
M G
MG
D000138:Acidosis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D000293:Adolescent; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy; D004630:Emergencies; D005260:Female; D005279:Fenoprofen / Q000009:adverse effects*; D006801:Humans; D010666:Phenylpropionates / Q000009:adverse effects*; D013406:Suicide, Attempted
D010666:Phenylpropionates; D005279:Fenoprofen