title: Hemodynamic effects of intravenous procainamide during ventricular tachycardia.
abstract: Radionuclide angiography was used to study the hemodynamic effects of intravenous procainamide during stable monomorphic ventricular tachycardia. In four patients studied without procainamide, the ejection fraction was 25% +/- 2.4% during normal sinus rhythm, dropped to 11.3% +/- 2.2% (p less than 0.05) at the onset of ventricular tachycardia, increased to 16.7% +/- 1.7% after remaining in ventricular tachycardia for 10 minutes, and returned to 25.3% +/- 3.7% in sinus rhythm. In the 10 study patients, ejection fraction dropped from 36% +/- 5.8% in sinus rhythm to 25% +/- 5.1% in ventricular tachycardia (p less than 0.2). Ejection fraction decreased further (23% +/- 5.0%) following low doses of procainamide (140 +/- 52 mg) despite cycle length prolongation (354 +/- 18 msec versus 373 +/- 21 msec, p less than 0.5). In 8 of 10 patients, there was a progressive increase in the ejection fraction (28.8% +/- 4.1%). Ventricular tachycardia onset also resulted in a decrease in cardiac output and end-diastolic and end-systolic volumes. Two patients who tolerated procainamide in sinus rhythm showed hemodynamic collapse secondary to procainamide during ventricular tachycardia. We conclude that in some patients hemodynamic intolerance to an antiarrhythmic drug may only become evident during ventricular tachycardia.
authors.affiliation: Mercy General Hospital, Sacramento, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Purves
authors.forename: R
authors.initials: R
authors.lastname: Yee
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: G
authors.initials: G
authors.lastname: Jablonsky
authors.forename: W J
authors.initials: WJ
authors.lastname: Kostuk
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000097:blood / Q000627:therapeutic use*; D011875:Radionuclide Angiography; D013484:Supination; D013575:Syncope / Q000188:drug therapy / Q000503:physiopathology; D013610:Tachycardia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D011342:Procainamide