Pharmacokinetics of tinidazole in the horse.
Serum tinidazole concentrations were monitored in five clinically healthy adult horses after intravenous (i.v.) and oral administration of the drug (15 mg/kg and 25 mg/kg, respectively). After i.v. administration, the mean residence time was 7.0 h, the elimination half-life 5.2 h and the body clearance rate 1.6 ml/min/kg. The distribution volume was found to be 660 ml/kg. After oral administration, the mean residence time was 8.5 h, the absorption half-life 1.1 h and the bioavailability essentially 100%. In view of the in-vitro sensitivities of various anaerobic bacteria, a dosage of 10-15 mg/kg of tinidazole, orally, at 12-h intervals, can be recommended for the treatment of anaerobic infections in horses.
Pyörälä
S
S
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Hautjärvi, Finland.
Kotilainen
T
T
Silvennoinen
P
P
Hänninen
U
U
Mero
M
M
Kaartinen
L
L
D000284:Administration, Oral; D000818:Animals; D001439:Bacteroides / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects; D005260:Female; D005673:Fusobacterium / Q000187:drug effects; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008657:Metabolic Clearance Rate; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000493:pharmacokinetics*; D013997:Time Factors; D014011:Tinidazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D009593:Nitroimidazoles; D014011:Tinidazole