title: [Anti-tumor marine natural products].
abstract: In anticipation of developing new anti-cancer drugs from marine organisms of rich species, a variety of anti-tumor substances having diverse chemical structures have been discovered. Among those marine anti-tumor substances, which were reviewed in a previous paper [Jpn. J. Cancer Chemother., 16, 1-8 (1989)], several compounds promising as anti-cancer drugs are detailed in this article. They are didemnin B from marine tunicate, bryostatin 1 from marine bryozoa, and dolastatin 10 from sea hare. In addition, several anti-tumor marine sponge constituents: halichondrin B, calyculin A, and mycalamides A and B, are briefly reviewed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University 1-6, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D054713:Bryostatins; D004267:DNA Viruses / Q000187:drug effects; D047630:Depsipeptides; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007783:Lactones / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D018942:Macrolides; D008386:Marine Biology; D008546:Melanoma, Experimental / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010456:Peptides, Cyclic / Q000494:pharmacology*
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D054713:Bryostatins; D047630:Depsipeptides; D007166:Immunosuppressive Agents; D007783:Lactones; D018942:Macrolides; D010456:Peptides, Cyclic; C046785:bryostatin 1; C030051:didemnins