title: Expression of immunoreactivity for Ca-binding protein, spot 35 in the interstitial cell of the rat pineal organ.
abstract: In the rat pineal organ numerous stellate cells exhibited intense immunoreactivity for calcium-binding spot 35 protein. Because of their peculiar shape and ultrastructure, identical to those of intrapineal S-100-immunoreactive cells, the spot 35-immunoreactive stellate cells were identified as the interstitial cells. The comparison of the morphology and population density of spot 35-, S-100-, and GFAP (glial fibrillar acidic protein)-immunoreactive cells, suggests that spot 35-immunoreactive cells represent a major subpopulation of the interstitial cells, all of which are S-100-immunoreactive and generally considered to be of glial nature, while GFAP-immunoreactive cells represent a minor subpopulation of the interstitial cells located in the proximal part close to the pineal stalk. This is the first report describing the occurrence of the calcium-binding protein in cells of glial nature.
authors.affiliation: Department of Anatomy, School of Medicine, Kanazawa University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Yamakuni
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D017317:Annexin A6; D015415:Biomarkers; D002135:Calcium-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D010870:Pineal Gland / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism
chemical_list: D017317:Annexin A6; D015415:Biomarkers; D002135:Calcium-Binding Proteins; C030564:S-100 calcium-binding protein alpha subunit; D009418:S100 Proteins