Long-term actions of d-fenfluramine in two rat models of obesity. II. Responses to stress.
In the previous study (part I), we reported that a 28-day regimen of d-fenfluramine administered via osmotic pump sustained weight reductions in normal weight and obese rats without depleting brain 5-HT. Peripheral actions of d-fenfluramine were also examined. Here we extend those findings to night-time observations and to stressful conditions. This treatment regimen had no effects on night-time concentrations of insulin, triglycerides or corticosterone or on the stress-induced rise in triglycerides and corticosterone. The thermic response to cold was unaltered. Glucose tolerance was enhanced in lean, but not obese rats.
Carlton
J
J
Department of Psychology, University of Florida, Gainesville.
Rowland
N E
NE
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013312:Stress, Physiological / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D005277:Fenfluramine; D012701:Serotonin; D003345:Corticosterone