Nitroarginine inhibits endothelium-derived relaxation.
Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 10(2) microM NO2Arg was reduced to 10.1 +/- 4.3% (n = 5). L-arginine (10(2) microM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO2Arg. These results indicate that NO2Arg is a novel inhibitor of endothelium-derived relaxation.
Kobayashi
Y
Y
Department of Pharmacology, Shimane Medical University, Izumo, Japan.
Hattori
K
K
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D019335:Nitroarginine; D010208:Papaverine / Q000494:pharmacology; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects
D019335:Nitroarginine; D001120:Arginine; D010208:Papaverine; D000109:Acetylcholine