title: Thyroidectomy for amiodarone-induced thyrotoxicosis.
abstract: Amiodarone hydrochloride, an iodine-rich drug used in the treatment of tachyarrhythmias, is responsible for the development of thyrotoxicosis in approximately 10% of patients who reside in areas of moderate iodine deficiency. Treatment of amiodarone-induced thyrotoxicosis is difficult since the drug has a prolonged half-life, cardiac decompensation due to underlying heart disease occurs often, and discontinuation of amiodarone therapy may not be possible. We report a patient with severe thyrotoxicosis who received amiodarone for 34 months. Prolonged treatment with methimazole, potassium perchlorate, iopanoic acid, and dexamethasone was unsuccessful in controlling the hyperthyroid state. A near-total thyroidectomy resulted in rapid amelioration of thyrotoxicosis. Since surgery results in rapid control of thyrotoxicosis and permits continued therapy with amiodarone, we suggest that near-total thyroidectomy warrants consideration as definitive treatment for resistant amiodarone-induced thyrotoxicosis.
authors.affiliation: Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester 01655.
authors.forename: A P
authors.initials: AP
authors.lastname: Farwell
authors.forename: S L
authors.initials: SL
authors.lastname: Abend
authors.forename: S K
authors.initials: SK
authors.lastname: Huang
authors.forename: N A
authors.initials: NA
authors.lastname: Patwardhan
authors.forename: L E
authors.initials: LE
authors.lastname: Braverman
mesh_terms: D000638:Amiodarone / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000503:physiopathology / Q000601:surgery
chemical_list: D000638:Amiodarone