Contact allergy to Bronopol.
A total of 8149 patients were patch tested with the preservative Bronopol in 7 European contact clinics. The majority of patients (6507) were investigated in London. Reactivity was low, with a total of 10 irritant (0.12%) and 38 allergic reactions (0.47%). In only 17 cases (0.21%) was the patch test reaction to Bronopol considered to be of current or past clinical relevance. Concomitant sensitization to formaldehyde was present in about 1/3 of patients. Based on these figures, the present sensitization rate to Bronopol in Europe seems to be quite low, which may be related to its less frequent use as a preservative in cosmetics and medicaments in comparison to parabens or isothiazolinones.
Frosch
P J
PJ
Department of Dermatology, University of Heidelberg, FRG.
White
I R
IR
Rycroft
R J
RJ
Lahti
A
A
Burrows
D
D
Camarasa
J G
JG
Ducombs
G
G
Wilkinson
J D
JD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000276:immunology*; D003358:Cosmetics / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology*; D005260:Female; D005557:Formaldehyde / Q000276:immunology; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D011409:Propylene Glycols / Q000009:adverse effects / Q000276:immunology*; D012737:Sex Factors
D000890:Anti-Infective Agents; D003358:Cosmetics; D011409:Propylene Glycols; D005557:Formaldehyde; C006827:bronopol