title: Lung function in patients with prior poliomyelitis.
abstract: Lung volumes and spirometric flows, maximal respiratory pressures, lung diffusion capacity and blood gases were evaluated in 20 patients with prior poliomyelitis and compared with data from an age- and sex-matched control group. In the polio patients, static lung volumes and pulmonary flow capacity were significantly reduced to approximately 65% of the values of the control group. However, expiratory and inspiratory flows were normal in relation to lung volumes, while maximal respiratory pressures were significantly reduced in the polio patients. Static lung volumes and forced flows were correlated with the maximal respiratory pressures both in the polio patients and in the controls. However, when the muscle force in the polio patients decreased below a certain level, it became more important as a determinant of lung-flow capacity. The polio patients had a significantly increased PCO2 but a normal oxygen saturation and PCO2 was inversely correlated with the maximal respiratory pressures in the patients but not in the controls. The lung diffusion capacity was reduced in the polio patients compared to the controls, but less markedly than vital and total lung capacity. The findings indicate a restrictive respiratory dysfunction and alveolar hypoventilation most probably due to weakness of the respiratory muscles.
authors.affiliation: Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Borg
authors.forename: L
authors.initials: L
authors.lastname: Kaijser
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011051:Poliomyelitis / Q000150:complications*; D012120:Respiration Disorders / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012129:Respiratory Function Tests