Uptake of trimethoprim and metronidazole in the seminal vesicle: experimental study.
A rat model for determining drug levels in the seminal vesicle was developed. In separate studies, trimethoprim and metronidazole were injected intravenously into rats and assays of seminal vesicle, plasma, and prostate performed. Drug levels were detected early in both the seminal vesicle and prostate. This appears to be the first study to report drug levels in the seminal vesicle. Metronidazole levels in the seminal vesicle were very low and short lived.
Fiorica
V M
VM
University of Oklahoma, Health Sciences Center, College of Pharmacy.
Albers
D D
DD
Tu
Y H
YH
Allen
L V
LV
D000818:Animals; D008297:Male; D008795:Metronidazole / Q000493:pharmacokinetics*; D011467:Prostate / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000032:analysis / Q000378:metabolism*; D014295:Trimethoprim / Q000493:pharmacokinetics*
D008795:Metronidazole; D014295:Trimethoprim