Effect of bismuth subsalicylate on Clostridium difficile colitis in hamsters.
The therapeutic effect of bismuth subsalicylate (BSS, Pepto-Bismol) in Clostridium difficile colitis was studied in golden Syrian hamsters. C. difficile was fed to the hamsters by orogastric intubation 2-3 days after their arrival. Clindamycin (1.5 mg per animal) was given intraperitoneally 4 days later. Twenty-four hours after challenge with clindamycin, animals were given BSS at dosages of 5, 10, and 15 mg twice daily for 5 days by orogastric intubation. Controls included untreated animals and those given 5 mg of vancomycin once daily by intubation. Delay in the time of death was observed in all BSS-treated animals and was statistically significant on days 4-6 in those receiving 15 mg twice daily. Vancomycin produced a greater delay in death than did BSS. Our study suggests that BSS at a dosage of 15 mg twice daily has some therapeutic effect on C. difficile colitis in hamsters.
Chang
T W
TW
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111.
Dong
M Y
MY
Gorbach
S L
SL
D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000032:analysis; D001729:Bismuth / Q000627:therapeutic use*; D002981:Clindamycin / Q000009:adverse effects; D003013:Clostridium; D006224:Cricetinae; D004195:Disease Models, Animal; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy*; D005243:Feces / Q000032:analysis; D008297:Male; D008647:Mesocricetus; D009942:Organometallic Compounds / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D009942:Organometallic Compounds; D012459:Salicylates; C031815:toxB protein, Clostridium difficile; D002981:Clindamycin; C015715:bismuth subsalicylate; D014640:Vancomycin; D001729:Bismuth