title: Amniotic fluid alpha 1-antitrypsin concentration in premature rupture of the membranes.
abstract: Premature rupture of the membranes is probably a result of a loss in amniotic membrane collagen. A recent report that the concentration of alpha 1-antitrypsin was decreased in patients with premature rupture of the membranes suggested a generalized defect in such pregnancies. In this study we compared the concentration of alpha 1-antitrypsin in samples from pregnancies with premature rupture of the membranes and from pregnancies with preterm labor at similar gestational age. No difference in alpha 1-antitrypsin concentration was noted between these groups or between samples with or without intrauterine infection. These results support a localized inflammation and necrosis of the membranes at the site of rupture.
authors.affiliation: Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33612.
authors.forename: W F
authors.initials: WF
authors.lastname: O'Brien
authors.forename: R A
authors.initials: RA
authors.lastname: Knuppel
authors.forename: W J
authors.initials: WJ
authors.lastname: Morales
authors.forename: J L
authors.initials: JL
authors.lastname: Angel
authors.forename: C T
authors.initials: CT
authors.lastname: Torres
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D005333:Fetus; D006801:Humans; D007752:Obstetric Labor, Premature / Q000378:metabolism; D009994:Osmolar Concentration; D011247:Pregnancy; D012727:Sex Characteristics; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D000515:alpha 1-Antitrypsin