title: [Pulmonary function and survival of patients with alpha 1-antitrypsin deficiency, residents of Copenhagen].
abstract: From 1976 to 1987 alpha 1-antitrypsine deficiency type PiZZ was diagnosed in 89 patients living in the Copenhagen urban area (mean age: 45 years). Spirometry was performed yearly in 66 of these patients (mean observation period was 50 months). At the time of diagnosis basic FEV1 was significantly lower in smokers and ex-smokers than in patients who had never smoked (45%, 44% and 84% of predicted normal, respectively). However, the decline in FEV1 was similar (3% per year) in all three categories of smokers. Our results indicate that both smokers and non-smokers are at risk of developing pulmonary emphysema, however, the disease usually appears later in life or not at all in non smokers.
authors.affiliation: Bispebjerg Hospital, København, Medicinsk Afdeling.
authors.forename: T
authors.initials: T
authors.lastname: Evald
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: S
authors.initials: S
authors.lastname: Keittelmann
authors.forename: K
authors.initials: K
authors.lastname: Viskum
authors.forename: A
authors.initials: A
authors.lastname: Kok-Jensen
mesh_terms: D000328:Adult; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008875:Middle Aged; D011379:Prognosis; D019896:alpha 1-Antitrypsin Deficiency
vernacular_title: Lungefunktion og overlevelse hos patienter med alfa 1-antitrypsinmangel bosiddende i København.