title: Presence of pancreatic trypsin inhibitor in adrenal medullary chromaffin cells.
abstract: A bovine pancreatic trypsin inhibitor was isolated from bovine adrenal medullary chromaffin granules. Its N-terminal sequence is: arg-pro-asp-phe-cys-leu-glu-pro-pro-tyr-thr-gly-pro-cys-lys-ala-arg-ile- arg-tyr- phe-tyr-asn-ala-lys-ala-gly-leu-cys-gln-thr-phe-val-tyr-gly-gly-cys-arg- ala-lys-arg-asn-asn-phe-lys- which corresponds precisely with the N-terminus of Bovine Pancreatic Trypsin inhibitor. The presence of this inhibitor in these granules suggests another method of regulating the prohormone proteases present there.
authors.affiliation: Molecular Biology Department, University of Wyoming, Laramie 82071-3944.
authors.forename: R V
authors.initials: RV
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Ray
authors.forename: R
authors.initials: R
authors.lastname: Coguill
authors.forename: W
authors.initials: W
authors.lastname: Kruggel
mesh_terms: D000313:Adrenal Medulla / Q000032:analysis*; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D011863:Radioimmunoassay; D012689:Sequence Homology, Nucleic Acid; D013050:Spectrometry, Fluorescence; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000032:analysis* / Q000302:isolation & purification; D014361:Trypsin Inhibitors / Q000032:analysis*
chemical_list: D014361:Trypsin Inhibitors; D014359:Trypsin Inhibitor, Kazal Pancreatic