title: Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics do.
abstract: At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not.
authors.affiliation: Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Riesbeck
authors.forename: A
authors.initials: A
authors.lastname: Bredberg
authors.forename: A
authors.initials: A
authors.lastname: Forsgren
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D002939:Ciprofloxacin / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010761:Phosphorus Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000900:Anti-Bacterial Agents; D010761:Phosphorus Radioisotopes; D002939:Ciprofloxacin