title: Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.
abstract: In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus. Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.
authors.affiliation: Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Aricó
authors.forename: L
authors.initials: L
authors.lastname: Nespoli
authors.forename: F
authors.initials: F
authors.lastname: Porta
authors.forename: D
authors.initials: D
authors.lastname: Caselli
authors.forename: E
authors.initials: E
authors.lastname: Raiteri
authors.forename: G R
authors.initials: GR
authors.lastname: Burgio
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008508:Medication Errors; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
chemical_list: D004317:Doxorubicin