Symptomatic hypomagnesemia associated with gentamicin therapy.
Seven patients (3 females, 4 males) developed symptomatic hypomagnesemia, hypocalcemia, and hypokalemia following gentamicin therapy. The excessive and inappropriate urinary excretion of magnesium and potassium in the presence of subnormal serum concentrations was noted. A significant correlation was found between the total cumulative dose of gentamicin and serum Mg concentration (r = 0.76, p less than 0.05), as well as between the renal wasting of Mg and the total cumulative dose of gentamicin administered (r = 0.89, p less than 0.01). The gentamicin-induced Mg depletion is a very rare but important complication which is most likely to occur when the drug is given to older patients in large doses over extended periods of time.
Kes
P
P
Department of Nephrology, University Hospital, Dr. M. Stojanovic, Zagreb, Yugoslavia.
Reiner
Z
Z
D000368:Aged; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced; D007008:Hypokalemia / Q000139:chemically induced; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008275:Magnesium Deficiency / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000378:metabolism; D012008:Recurrence; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy
D005839:Gentamicins; D008274:Magnesium; D011188:Potassium