Exposure to toluene increases the urinary excretion of D-glucaric acid.
Workers at a printing plant exposed to low concentrations of toluene (43-401 mg/m3, median 155 mg/m3) had increased urinary D-glucaric acid (3.55-5.12 mmol/mol creatinine) excretion at the end of the shift compared with controls (2.45-3.35 mmol/mol creatinine). No increase was found after the summer holiday (1.92-2.89 mmol/mol creatinine) but excretion had increased two weeks later (4.05-5.55 mmol/mol creatinine). These changes in the excretion of D-glucaric acid were not correlated to levels of exposure, to changes of urinary hippuric acid and o-cresol half lives (three to eight hours), nor to o-cresol/hippuric acid concentration ratios when measured at the end of daily exposure. Since a significant intra and interindividual variability of urinary D-glucaric acid was found in all groups, urinary D-glucaric acid excretion is suitable to monitor group but not individual exposure.
Moretto
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Istituto di Medicina del Lavoro dell'Università di Padova, Padua, Italy.
Lotti
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D004781:Environmental Exposure; D004784:Environmental Monitoring; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D011327:Printing; D013400:Sugar Acids / Q000652:urine*; D014050:Toluene / Q000009:adverse effects*
D013400:Sugar Acids; D014050:Toluene; D005937:Glucaric Acid