Could antiprogesterones be used as alternative cervical ripening agents?
We measured the effect of a progesterone antagonist on the pregnant cervix with a custom-built cervicometer. The change in cervical diameter was studied in 11 pregnant patients after oral administration of 600 mg of RU-486. In all cases RU-486 ripened the cervix (p = 0.0007). The average increase in diameter was 13% (95% confidence limits, 10% to 16%).
Johnson
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Department of Obstetrics and Gynaecology, St. James' University Hospital, Leeds, England.
Bryce
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FC
D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D004106:Dilatation; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000037:antagonists & inhibitors*
D015735:Mifepristone; D011374:Progesterone