Complications of bone marrow transplantation in Chinese.
Forty-three patients with hematopoietic disease were treated with intensive chemotherapy and radiotherapy, followed by allogeneic bone marrow transplantation (BMT) from 28 HLA-identical and 10 one to two antigen haploidentical sibling donors and autologous BMT (5 cases). Of these cases, there were 21 with acute nonlymphocytic leukemia (ANLL), 5 with acute lymphocytic leukemia (ALL), 6 with chronic myelocytic leukemia (CML), 2 with Hodgkin's disease (HD), 8 with severe-form aplastic anemia (SAA) and 1 with thalassemia. Complications of BMT were evaluated including acute graft-versus-host disease (GVHD), interstitial pneumonia (IP), veno-occlusive liver disease (VOD), abnormalities of liver function (LF), and alteration of hepatitis B virus (HBV) markers. In thirty-three patients who were followed up for more than 3 months, we found that the incidence of moderate to severe acute GVHD (9.1%) and IP (two cases, 4.7%) were low. No VOD occurred in our series. During the follow-up period, 27 out of 35 patients (77%) had high alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels, even up to 1000 U/liter; however, only one patient succumbed to a hepatitis-related complication. Previous hepatic damage from HBV infection before BMT does not appear to increase the risk of posttransplant morbidity and mortality.
Chen
P M
PM
Department of Internal Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.
Fan
S
S
Liu
C J
CJ
Hsieh
R K
RK
Liu
J H
JH
Chuang
M W
MW
Liu
R S
RS
Tzeng
C H
CH
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D006509:Hepatitis B / Q000150:complications; D006648:Histocompatibility; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000453:epidemiology / Q000209:etiology; D013624:Taiwan / Q000453:epidemiology