[Cardiac side effects of 5-fluorouracil].
In four patients (a 54-year-old man and three women aged 57, 60 and 65 years, respectively) with colorectal carcinoma and no obvious cardiac abnormality anginal symptoms and ECG changes occurred during chemotherapy with 5-fluorouracil at a dose of 400 and 600 mg/m2. The ECG changes consisted of descending ST depressions with preterminally negative T waves, terminally negative T waves, ventricular extrasystoles and sinus tachycardia with intermittent atrial fibrillation. The signs first appeared between the second and fourth day of treatment; in two patients they improved with glyceryl trinitrate. A few days after 5-fluorouracil had last been administered all ECG changes had disappeared. The causes of cardiotoxicity of the drug remain unknown.
May
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D
Innere Klinik und Poliklinik, Universitätsklinikum Essen.
Wandl
U
U
Becher
R
R
Niederle
N
N
Schmidt
C G
CG
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005472:Fluorouracil
Kardiale Nebenwirkungen von 5-Fluorouracil.