title: Serum albumin: its relationship to marrow and renal toxicity from platinum-based combination chemotherapy.
abstract: One hundred and three patients treated with CAP chemotherapy were evaluated to determine the relationship between low prechemotherapy serum albumin (less than 3 g/dl) and low WBC nadir (less than 2000 cells/mm3). Additionally, the relationship of serum albumin to renal toxicity (delta serum creatinine) was examined. Low prechemotherapy serum albumin appears to be a marker for advanced disease, but does not appear to predict marrow or renal toxicity.
authors.affiliation: Department of Obstetrics and Gynecology, University of Vermont, Burlington 05401.
authors.forename: J L
authors.initials: JL
authors.lastname: Belinson
authors.forename: M A
authors.initials: MA
authors.lastname: Jarrell
authors.forename: M
authors.initials: M
authors.lastname: McClure
authors.forename: P M
authors.initials: PM
authors.lastname: Kulig
authors.forename: G J
authors.initials: GJ
authors.lastname: Badger
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000097:blood / Q000139:chemically induced*; D002945:Cisplatin / Q000008:administration & dosage; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D007958:Leukocyte Count / Q000187:drug effects; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D012709:Serum Albumin / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D012709:Serum Albumin; D004317:Doxorubicin; D003520:Cyclophosphamide; D003404:Creatinine; D002945:Cisplatin