title: Nucleus basalis lesions fail to induce senile plaques in the rat.
abstract: Fourteen months after receiving bilateral ibotenic acid lesions of the nucleus basalis magnocellaris (NBM), male rats demonstrated impairment in spatial learning in a water maze task, increased incidence of high voltage spindles, and significant depletion of cortical choline acetyltransferase (ChAT) activity. Histological evaluation revealed decreased acetylcholinesterase (AChE) staining but no plaque-like structures in the cortex.
authors.affiliation: Neurology Service, VA Medical Center, San Diego, California 92161.
authors.forename: L J
authors.initials: LJ
authors.lastname: Thal
authors.forename: R J
authors.initials: RJ
authors.lastname: Mandel
authors.forename: R D
authors.initials: RD
authors.lastname: Terry
authors.forename: G
authors.initials: G
authors.lastname: Buzsaki
authors.forename: F H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease; D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004195:Disease Models, Animal; D004569:Electroencephalography; D007051:Ibotenic Acid / Q000494:pharmacology*; D007858:Learning / Q000502:physiology; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010080:Oxazoles; D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase