FAM chemotherapy +/- aminoglutethimide in the treatment of pancreatic carcinoma.
Human pancreas contains receptors for estrogens and androgens as well as aromatase activity. FAM chemotherapy was administered to 14 patients with pancreatic cancer (seven at Stage IV). The median survival of these patients was 24.4 +/- 4.8 weeks. FAM chemotherapy plus aminoglutethimide/hydrocortisone (AG/HC) (250 mg bid AG + 20 mg bid HC) was administered to 14 patients (seven at stage IV). The median survival of this group was 17.3 +/- 2.9 weeks (P = 0.74 vs FAM alone). We conclude that addition of AG/HC does not add to the survival of patients with carcinoma of the pancreas treated with chemotherapy.
Lipton
A
A
Central Pennsylvania Oncology Group, Hershey 17033.
Harvey
H A
HA
Santen
R J
RJ
Stryker
J A
JA
Barnes
S G
SG
Walker
B K
BK
Dixon
R H
RH
Givant
E M
EM
Bartholomew
M J
MJ
Nadjafi
C
C
D000616:Aminoglutethimide / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D011446:Prospective Studies; D011897:Random Allocation; D015996:Survival Rate
D008937:Mitomycins; D000616:Aminoglutethimide; D016685:Mitomycin; D004317:Doxorubicin; D005472:Fluorouracil; D006854:Hydrocortisone