Plasmacytoid T-cells in a reactive lymph node. Detection by flow cytometry?
Plasmacytoid T-cells (PTCs) are a histologically recognized component of some reactive nodes. To the best of the authors' knowledge, plasmacytoid T-cells have never been recognized as a distinct cell population in a reactive lymph node using cell suspension flow cytometric studies. The authors here report a case of reactive lymph node hyperplasia in which prominent aggregates of PTCs were present and a distinct cell population with an immunophenotype characteristic of PTCs was identified by flow cytometry. Aside from the recognition of PTCs, this observation is important so that cell suspensions showing a distinct population of PTCs with an "aberrant" T-cell phenotype are not misinterpreted as providing evidence for a T-cell neoplasm.
Brubaker
R
R
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati.
Swerdlow
S H
SH
D000328:Adult; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology