[Use of the stable nitrogen isotope 15N in assessing liver metabolism in hormonal contraception].
In 37 women with long-term use of oral contraceptives (average use 13.4 years) and 12 women who had not taken oral contraceptives for at least 5 years we determined the serum enzymes ALAT, ASAT, Gamma-GT and conducted the 15N-ammonium test as a marker of partial metabolic performance of the liver. In addition we studied total protein, protein fractions in the serum and haematologic parameter. 18 out of 37 women showed a morbid result in the 15N-ammonium test. In 4 of these 18 women morphological changes representing hepatic damage caused by contraceptives could be detected. On the average ALAT, Gamma-GT and 15N-ammonium test in both groups are clearly different. Because the enzymic levels are being in the normal range, only the 15N ammonium test enables to give a hepatotoxic evidence. It is possible to conclude that long-term use of oral contraceptives influences the liver metabolism.
Metzner
C
C
Poliklinik, Bezirkskrankenhauses, Leipzig.
Jung
K
K
Laue
R
R
Wagenknecht
C
C
Graubaum
H J
HJ
Kranz
D
D
Seifert
P
P
D000328:Adult; D000641:Ammonia / Q000652:urine; D000643:Ammonium Chloride; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008111:Liver Function Tests / Q000379:methods*; D009587:Nitrogen Isotopes
D003278:Contraceptives, Oral, Hormonal; D009587:Nitrogen Isotopes; D000643:Ammonium Chloride; D000641:Ammonia
Einsatz des stabilen Stickstoffisotops 15N zur Beurteilung des Leberstoffwechsels bei hormonaler Kontrazeption.