title: HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene.
abstract: Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.
authors.affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: K T
authors.initials: KT
authors.lastname: Jeang
authors.forename: S G
authors.initials: SG
authors.lastname: Widen
authors.forename: O J
authors.initials: OJ
authors.lastname: Semmes
authors.forename: S H
authors.initials: SH
authors.lastname: Wilson
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D002461:Cell Line, Transformed; D004256:DNA Polymerase I / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D015967:Gene Expression Regulation, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010957:Plasmids; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D012091:Repetitive Sequences, Nucleic Acid; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014162:Transfection
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D004256:DNA Polymerase I