Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
Bökkerink
J P
JP
Department of Pediatrics, University Hospital of Nijmegen, The Netherlands.
Damen
F J
FJ
Hulscher
M W
MW
Bakker
M A
MA
De Abreu
R A
RA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004357:Drug Synergism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D015122:Mercaptopurine / Q000008:administration & dosage / Q000494:pharmacology*; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011687:Purines / Q000378:metabolism; D013936:Thymidine / Q000096:biosynthesis; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D004273:DNA, Neoplasm; D011687:Purines; D015122:Mercaptopurine; D013936:Thymidine; D008727:Methotrexate