title: Hepatic hypervitaminosis A: a familial observation.
abstract: Four siblings with hepatic fibrosis are described. The liver damage in these patients was secondary to chronic ingestion of massive doses of vitamin A for congenital ichthyosis. Although the extrahepatic manifestations were helpful in the diagnosis of hypervitaminosis A, the distinctive features of hepatic histopathology were confirmatory. The plasma concentrations of vitamin A and retinol-binding protein were misleading. The recovery from the liver damage in these patients was slow despite a complete withdrawal of the vitamin A intake. These cases show the importance of hepatic vitamin A assessment in the diagnosis of hepatic fibrosis.
authors.affiliation: Service de Pédiatrie et Génétique Médicale, Hôpital de la Timone, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Sarles
authors.forename: C
authors.initials: C
authors.lastname: Scheiner
authors.forename: M
authors.initials: M
authors.lastname: Sarran
authors.forename: F
authors.initials: F
authors.lastname: Giraud
mesh_terms: D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000139:chemically induced* / Q000175:diagnosis; D007057:Ichthyosis / Q000188:drug therapy* / Q000235:genetics; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D014801:Vitamin A / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014801:Vitamin A