title: A protocol for satisfying the ethical issues raised by oocyte donation: the free, anonymous, and fertile donors.
abstract: A new protocol was developed to provide participants of our oocyte donation program with oocytes donated by donors who were not financially rewarded, were anonymous, and fertile. Each participant provided an oocyte donor selected among fertile friends or family members. The retrieved oocytes were anonymously exchanged between phenotypically matched donor-recipient pairs. In the first 30 months of activity, we obtained 111 embryos suitable for transfer or cryopreservation from 52 retrievals, and 40 embryo transfers (ETs) were performed. Recipients received oral Estradiol-valerate and vaginal micronized progesterone. Fifteen embryos were transferred in 8 ETs conducted after donor-recipient synchronization. This resulted in four pregnancies, all ongoing (ongoing pregnancy rate 50% per transfer). Of the 96 cryopreserved embryos, 82 were thawed for ET, and 45 surviving embryos were transferred in 32 ETs. This resulted in eight pregnancies, with six ongoing or delivered (ongoing pregnancy rate 19% per transfer). The overall ongoing pregnancy rate of 25% per transfer indicates that our approach is a viable method for obtaining donated oocytes while respecting the ethical guidelines that recommended that donation of human gametes should be free, and from anonymous and fertile donors. Furthermore, guaranteeing anonymous oocyte donation had practical importance because, for many volunteer donors, it played a crucial role in their decision to donate.
authors.affiliation: Université of Paris-Sud, Hôpital Antoine Béclère, France.
authors.forename: R
authors.initials: R
authors.lastname: Frydman
authors.forename: H
authors.initials: H
authors.lastname: Letur-Könirsch
authors.forename: D
authors.initials: D
authors.lastname: de Ziegler
authors.forename: M
authors.initials: M
authors.lastname: Bydlowski
authors.forename: A
authors.initials: A
authors.lastname: Raoul-Duval
authors.forename: J
authors.initials: J
authors.lastname: Selva
mesh_terms: D000328:Adult; D001675:Bioethics; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D018587:Oocyte Donation; D009865:Oocytes; D018454:Spouses; D014019:Tissue Donors