Determination of creatinine-related urinary uracil excretion in children by high-performance liquid chromatography.
Excretion rates of uracil and thymine in children (n = 140) and circadian rhythms of urinary uracil excretion (n = 9) were investigated by reversed-phase high-performance liquid chromatography with ultraviolet detection. Excretion values were related to urinary creatinine determined by Jaffé's method. Creatinine-related uracil excretion was not dependent on age or sex. The values seemed to be distributed according to a Gaussian graph in both school children and those in hospital. The intra-individual range was 1.32-23.70 mg uracil per g creatinine over a four-day period in one subject. Uracil excretion seems to be somewhat lower during the night.
Assmann
B
B
Fachrichtung Physiologische Chemie, Universität des Saarlandes, Homburg/Saar, F.R.G.
Haas
H J
HJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D014498:Uracil / Q000652:urine*
D014498:Uracil; D003404:Creatinine