title: The effects of hyperbaric oxygen on free flaps in rats.
abstract: The effects of hyperbaric oxygen on survival were investigated in free flaps and island flaps. Skin flaps transplanted following 18, 21, and 24 hours of preservation at 24 degrees C demonstrated survival rates of 20%, 10%, and 0%, respectively. Treatment with hyperbaric 100% oxygen improved the survival rates to 66%, 67%, and 40%. A preservation time of 21 to 24 hours at room temperature appears to be the threshold of irreversible ischemic damage. In acute island flaps, flap survival was improved significantly from 35% to 53% and 64% of the random flap area by preoperative or postoperative treatment, respectively. Prolonged preoperative and postoperative treatment improved survival to 66%.
authors.affiliation: Division of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: C M
authors.initials: CM
authors.lastname: Kaelin
authors.forename: M J
authors.initials: MJ
authors.lastname: Im
authors.forename: R A
authors.initials: RA
authors.lastname: Myers
authors.forename: P N
authors.initials: PN
authors.lastname: Manson
authors.forename: J E
authors.initials: JE
authors.lastname: Hoopes
mesh_terms: D000818:Animals; D005260:Female; D006931:Hyperbaric Oxygenation; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps; D014022:Tissue Survival