title: [Pleural symphysis with tetracyclines for pneumothorax. The value of thoracic peridural analgesia].
abstract: The aim of this study was to assess the value of peridural thoracic analgesia (ATP) to prevent pain observed during pleural symphysis with tetracycline (STP) for pneumothorax (PNO). 12 patients (age 27 +/- 6 years) having a spontaneous PNO benefited from 13 SPT (1 gm, tetracycline diluted in 60 cc of normal saline) under cover of an APT (at the D5-D6 level) with Fentanyl (0.1 mg) and Bupivacaine 0.5% adrenalin (1 mg/kg). The protocol was used on three successive days. Repeated determinations of blood bupivacaine levels were performed in 9 patients on the first day. No patient had an intolerable pain which required injection of parenteral morphine and/or an interruption of the protocol. For two patients (one of them having a right symphysis and then a left symphysis one month later) the treatment sessions to achieve a symphysis were totally painless. 10 patients experienced moderate pain, mainly on the first day, which was relieved by reinjection of peridural bupivacaine (25 mg) (n = 9) or by the parenteral injection of non morphine analgesia (n = 1). No patient had a respiratory depression, collapse or bradycardia. The blood bupivacaine levels were always significantly less than the toxic levels (1.6 mg). The results observed suggest that APT, (Fentanyl and Bupivacaine) is an effective method, non toxic and well tolerated for the prevention of intolerable pain which is seen in SPT for PNO.
authors.affiliation: Service de Pneumologie et de Réanimation, Hôtel-Dieu, Paris.
authors.forename: T
authors.initials: T
authors.lastname: Poirier
authors.forename: J P
authors.initials: JP
authors.lastname: Laaban
authors.forename: F
authors.initials: F
authors.lastname: Guyon
authors.forename: T K
authors.initials: TK
authors.lastname: Vuong
authors.forename: H
authors.initials: H
authors.lastname: Dermine
authors.forename: J
authors.initials: J
authors.lastname: Rochemaure
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000097:blood / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D007267:Injections; D008297:Male; D010994:Pleura; D010995:Pleural Diseases / Q000209:etiology; D011030:Pneumothorax / Q000188:drug therapy* / Q000517:prevention & control; D012008:Recurrence; D012119:Respiration / Q000187:drug effects; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D013752:Tetracycline; D005283:Fentanyl; D002045:Bupivacaine
vernacular_title: Symphyse pleurale aux tétracyclines pour pneumothorax. Intérêt de l'analgésie péridurale thoracique.