title: Malignant melanoma associated with melanocytoma of the optic disc.
abstract: A 61-year-old white man underwent enucleation because of progressive growth of a pigmented epipapillary tumor that was diagnosed 9 years earlier as an optic nerve and juxtapapillary melanocytoma. Histopathologic studies showed the tumor was a malignant melanoma of the optic disc and juxtapapillary retina and choroid. Foci of typical melanocytoma cells were within the tumor. The tumor produced segmental atrophy of the optic nerve. This is a rare example of a malignant melanoma developing in conjunction with a lesion that possessed typical clinical and histopathologic features of a melanocytoma of the optic disc.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: W E
authors.initials: WE
authors.lastname: Lieb
authors.forename: S
authors.initials: S
authors.lastname: Stern
mesh_terms: D002471:Cell Transformation, Neoplastic; D002829:Choroid / Q000473:pathology; D003390:Cranial Nerve Neoplasms / Q000473:pathology*; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000473:pathology*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology*; D009896:Optic Atrophy / Q000209:etiology; D009898:Optic Disk / Q000473:pathology*; D012160:Retina / Q000473:pathology