A double-blind assessment of segmental sensory changes with epidural fentanyl versus epidural saline in patients undergoing extracorporeal shock-wave lithotripsy.
Segmental changes to pin prick and cold stimuli were tested in a double-blind manner in pain-free patients scheduled for extracorporeal shockwave lithotripsy (ESWL). Fifty patients were randomly allocated to receive either epidural fentanyl (100 micrograms in 10 ml normal saline) or 10 ml epidural normal saline. In a further 25 patients an epidural catheter was inserted but no solution injected. In contrast to this latter group, epidural fentanyl and normal saline both produced segmental sensory changes. There were no significant differences between fentanyl and normal saline groups in the number of patients reporting sensory changes to pin prick, rate of onset of these changes, or segmental level. For cold stimuli, more patients in the fentanyl group than in the normal saline group reported a change (16 vs. 8; P = 0.02) but the segmental level was similar. The effect of normal saline as a diluent in epidurally administered opioids may be of clinical importance.
Hore
P J
PJ
Department of Anesthesiology, St. Vincent's Hospital, Melbourne, Victoria, Australia.
Silbert
B S
BS
Cook
R J
RJ
Beilby
D S
DS
D000767:Anesthesia, Epidural; D003080:Cold Temperature; D004311:Double-Blind Method; D005283:Fentanyl / Q000009:adverse effects; D006801:Humans; D007268:Injections, Epidural; D008096:Lithotripsy; D010812:Physical Stimulation; D011537:Pruritus / Q000139:chemically induced; D012677:Sensation; D012894:Sleep Stages / Q000187:drug effects; D012965:Sodium Chloride / Q000008:administration & dosage*
D012965:Sodium Chloride; D005283:Fentanyl