title: Infective conjunctivitis and corneal scarring in three brothers with sex linked hypogammaglobulinaemia (Bruton's disease).
abstract: The ocular findings in three brothers with Bruton's disease are reported. All three boys had purulent conjunctivitis, but the two older brothers also developed marked corneal scarring with visual impairment. Haemophilus influenzae was cultured from conjunctival swabs; it was resistant to neomycin but sensitive to chloramphenicol. Tear analysis showed that the three subjects had normal levels of lysozyme but no detectable IgA.
authors.affiliation: East Birmingham Hospital, Bordesley Green East.
authors.forename: T T
authors.initials: TT
authors.lastname: Hansel
authors.forename: D P
authors.initials: DP
authors.lastname: O'Neill
authors.forename: M L
authors.initials: ML
authors.lastname: Yee
authors.forename: J M
authors.initials: JM
authors.lastname: Gibson
authors.forename: R A
authors.initials: RA
authors.lastname: Thompson
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications / Q000235:genetics*; D002648:Child; D002701:Chloramphenicol / Q000627:therapeutic use; D003234:Conjunctivitis, Bacterial / Q000150:complications* / Q000188:drug therapy; D003316:Corneal Diseases / Q000150:complications*; D006192:Haemophilus Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D008297:Male; D009113:Muramidase / Q000032:analysis; D012635:Secretory Component / Q000032:analysis; D013666:Tears / Q000276:immunology
chemical_list: D007136:Immunoglobulins; D012635:Secretory Component; D002701:Chloramphenicol; D009113:Muramidase