title: Nonsteroidal anti-inflammatory drugs and coma: a case report of fenoprofen overdose.
abstract: We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.
authors.affiliation: Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401-0927.
authors.forename: J M
authors.initials: JM
authors.lastname: Kolodzik
authors.forename: M A
authors.initials: MA
authors.lastname: Eilers
authors.forename: M G
authors.initials: MG
authors.lastname: Angelos
mesh_terms: D000138:Acidosis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D000293:Adolescent; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy; D004630:Emergencies; D005260:Female; D005279:Fenoprofen / Q000009:adverse effects*; D006801:Humans; D010666:Phenylpropionates / Q000009:adverse effects*; D013406:Suicide, Attempted
chemical_list: D010666:Phenylpropionates; D005279:Fenoprofen