New biosynthetic anthracyclines related to barminomycins incorporating barbiturates in their moiety.
Three new anthracyclines, FCE 21424 (2), FCE 24366 (3) and FCE 24367 (4), were isolated from culture broths of Streptomyces peucetius and its mutant strains after addition of sodium barbiturates during the fermentation. Structural assignment, achieved through spectroscopic and degradative studies, that the new anthracyclines had a common barminomycin-like structure incorporating different barbiturate moieties. The new anthracyclines were found to display outstanding cytotoxicity and remarkable potency "in vivo" against P388 ascitic leukemia.
Cassinelli
G
G
Farmitalia Carlo Erba S.r.l., Research & Development, Milan, Italy.
Arlandini
E
E
Ballabio
M
M
Bordoni
T
T
Geroni
C
C
Giuliani
F
F
Grein
A
A
Merli
S
S
Rivola
G
G
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D006868:Hydrolysis; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D008970:Molecular Weight; D013302:Streptomyces / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic