Blood pressure and plasma catecholamines in never-treated parkinsonian patients: effect of a selective D1 agonist (CY 208-243).
We found blood pressure (BP), heart rate (HR), plasma norepinephrine (NE), and epinephrine (E) levels in the lying and the standing positions to be similar in never-treated parkinsonian patients (stages 1 and 2) and age-matched controls. CY 208-243, a new centrally active D1 agonist, significantly decreased BP, HR, and NE (but not E) values in the lying position; it elicited orthostatic hypotension and blunted the rise in NE elicited by standing up. These results indicate that the early stages of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and suggest the involvement of central D1-receptors in the control of sympathetic tone.
Durrieu
G
G
Laboratoire de Pharmacologie Médicale et Clinique (INSERM U317), Toulouse, France.
Senard
J M
JM
Rascol
O
O
Tran
M A
MA
Lataste
X
X
Rascol
A
A
Montastruc
J L
JL
D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001285:Atropine; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D010617:Phenanthridines / Q000627:therapeutic use*; D011187:Posture; D012016:Reference Values
D000978:Antiparkinson Agents; D007211:Indoles; D010617:Phenanthridines; C054531:CY 208-243; D001285:Atropine; D009638:Norepinephrine; D004837:Epinephrine