Characterization of the analgesic activity of ketorolac in mice.
The spectrum of analgesic activity of ketorolac tromethamine was evaluated with mice exposed to the hot-plate, tail-flick and writhing tests. Morphine and indomethacin were used as representative opioid and non-steroidal analgesics respectively. Ketorolac in doses of 5 or 7.5 mg/kg i.p. was active as an analgesic in all three of the procedures. In each case, naloxone (0.5 mg/kg i.p.) significantly decreased the analgesic activity of ketorolac. It was suggested that ketorolac might act in part by causing the release of endogenous opioids.
Domer
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Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112.
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D020911:Ketorolac Tromethamine; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014325:Tromethamine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D009270:Naloxone; D020911:Ketorolac Tromethamine; D009020:Morphine; D014046:Tolmetin; D007213:Indomethacin