title: Determination of ivermectin residues in swine tissues--an improved clean-up procedure using solid-phase extraction.
abstract: A rapid and sensitive HPLC method has been developed for the determination of ivermectin in swine tissues. The clean-up procedure is based on solid-phase extraction on a Bond-Elut C8 cartridge. The average recovery from spiked swine muscle tissue was 87% in the concentration range 2-20 micrograms/kg. The method has a limit of detection of 0.5-1 microgram/kg. A survey of the levels in muscle tissues from 35 sanitary slaughtered sows was made. Five samples were found to contain ivermectin at concentrations between 3.4 and 27.6 micrograms/kg. A good correlation (r = 0.9696) was found between these results and those obtained using another established method.
authors.affiliation: Nutrition Laboratory, National Food Administration, Uppsala, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Nordlander
authors.forename: H
authors.initials: H
authors.lastname: Johnsson
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D007559:Ivermectin / Q000032:analysis*; D008460:Meat / Q000032:analysis; D009132:Muscles / Q000032:analysis; D010865:Pilot Projects; D013552:Swine
chemical_list: D007559:Ivermectin