Detoxification with phenobarbital of alprazolam-dependent polysubstance abusers.
Alprazolam appears to have an abuse liability among opiate addicts, and detoxification can be prolonged. The authors describe experience with five methadone maintenance patients who were polysubstance abusers and were admitted specifically for detoxification from alprazolam dependence. Phenobarbital in tapering doses adequately suppressed withdrawal symptoms and shortened hospitalization.
Ravi
N V
NV
Center for Research and Treatment of Substance Abuse, Philadelphia Veterans Administration Medical Center, University of Pennsylvania.
Maany
I
I
Burke
W M
WM
Dhopesh
V
V
Woody
G E
GE
D000328:Adult; D000525:Alprazolam; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D010634:Phenobarbital / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000534:rehabilitation*
D013287:Illicit Drugs; D008691:Methadone; D010634:Phenobarbital; D000525:Alprazolam