Monoclonal antibody differentiates chicken A system alloantigens.
A monoclonal antibody (ISU-cA) was produced that recognized certain alloantigens of the chicken A blood group locus. Antigens produced by alleles A3, A4 and A8 were positive, and those produced by A2 and A5 were negative, by haemagglutination. The specificity of ISU-cA for chicken A blood group antigens was demonstrated by serologic analyses, genetic crosses and competitive inhibition of binding by anti-A alloantisera. To our knowledge, this is the first reported monoclonal antibody against a chicken blood group alloantigen system other than the B complex.
Fulton
J E
JE
Department of Animal Science and Immunobiology Program, Iowa State University, Ames 50011.
Briles
R W
RW
Lamont
S J
SJ
D000483:Alleles; D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001667:Binding, Competitive; D001717:Birds; D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology; D002645:Chickens / Q000097:blood / Q000235:genetics / Q000276:immunology*; D007519:Isoantigens / Q000235:genetics; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D007519:Isoantigens