Metergoline abolishes the prolactin response to buspirone.
Pretreatment of nine healthy subjects with the non-selective 5-HT receptor antagonist, metergoline (4 mg), abolished the increase in plasma prolactin produced by the anxiolytic drug, buspirone (15 mg). While these findings are consistent with a role for 5-HT receptors in the stimulatory effect of buspirone on plasma prolactin, a dopaminergic mechanism cannot be excluded by the present data.
Gregory
C A
CA
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
Anderson
I M
IM
Cowen
P J
PJ
D000328:Adult; D002065:Buspirone / Q000494:pharmacology*; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008711:Metergoline / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D011863:Radioimmunoassay
D004873:Ergolines; D008711:Metergoline; D011388:Prolactin; D002065:Buspirone