The effect of streptozotocin-induced diabetes on the in vivo acetylation capacity and the in vitro blood N-acetyltransferase activity of the adult male Sprague-Dawley rat.
Induction of experimental diabetes using streptozotocin significantly reduced the extent of sulphamethazine acetylation by Sprague-Dawley rats. This treatment did not significantly change the total amount of sulphonomide excreted in the urine. The in vitro blood N-acetyltransferase activity of rats treated with streptozotocin was significantly higher than that of untreated animals. Increasing the in vitro glucose concentration of blood samples from both groups significantly increased the amount of acetylsulphamethazine produced.
Lindsay
R M
RM
Department of Biochemical Medicine (University of Dundee), Ninewells Hospital and Medical School, U.K.
Baty
J D
JD
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000097:blood / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013418:Sulfamethazine / Q000378:metabolism* / Q000652:urine
D001786:Blood Glucose; D013418:Sulfamethazine; D000123:Acetyltransferases; D001191:Arylamine N-Acetyltransferase; D005947:Glucose