Multidimensional scaling of subjective judgements of drug similarities among ketocyclazocine, morphine, cyclazocine, naloxone and placebo.
Profiles of the subjective and physiologic effects of opioid drugs in man cannot be assigned with precision to specific opioid drug-receptor interactions. We administered a set of training doses of ketocyclazocine, morphine, cyclazocine, naloxone and placebo to 10 drug-using volunteers and obtained similarity judgements between each of 2 test doses of the drugs and a training dose. These data were submitted to multidimensional scaling analysis (INDSCAL) using both neighboring cells estimates and root mean square estimates to estimate missing cells in the data matrices. The results of these analyses are convergent, appear valid and indicate that there are three drug dimensions expressed in this data set: morphine versus placebo and naloxone; cyclazocine and ketocyclazocine versus placebo and naloxone; and ketocyclazocine versus cyclazocine. We interpret this result as supporting evidence that in the set of five drugs studied, three subjective states are induced.
Kumor
K M
KM
National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
Clark
W C
WC
Janal
M N
MN
Haertzen
C A
CA
D000328:Adult; D003496:Cyclazocine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016314:Ethylketocyclazocine / Q000031:analogs & derivatives*; D005795:Generalization, Stimulus; D006801:Humans; D008297:Male; D008960:Models, Psychological; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*
D009270:Naloxone; D016314:Ethylketocyclazocine; C012395:ketazocine; D009020:Morphine; D003496:Cyclazocine