[The ornithine decarboxylase activity of the gastric remnant mucosa: the effect of the duodenal juice with bile on the gastric mucosa].
Using male Wister rats, the ornithine decarboxylase (ODC) activity in the fundic mucosa has been determined from the duodenal juice with bile of a reflux model. The activity at 24 hours postoperatively presented a value approximately 18 times higher than the preoperative level. Though this level declined subsequently, it still was approximately two times higher four weeks later. The ODC activity in the corporal mucosa of humans was compared in 25 normal persons, in 21 patients with a gastric adenoma in 29 patients with a gastric cancer, in 20 patients who had undergone a Billroth I operation and in 20 patients who had undergone a Billroth II operation. No differences in ODC activity were observed among those with a gastric adenoma, a gastric cancer, and normal cases but significantly higher values were seen in cases with a remnant stomach, particularly those who had undergone Billroth II reconstructive surgery. Further, this activity tended to be especially high from 5 to 15 years postoperatively in cases with a gastric remnant.
Murakami
S
S
Dept. of Int. Med. Kure National Hospital.
Haruma
K
K
Sumii
K
K
Tari
A
A
Yoshihara
M
M
Kajiyama
G
G
Takezaki
E
E
Kagawa
K
K
Omori
H
H
D000368:Aged; D000818:Animals; D001646:Bile / Q000502:physiology*; D004383:Duodenogastric Reflux / Q000201:enzymology; D004386:Duodenum / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007419:Intestinal Secretions / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000201:enzymology / Q000601:surgery
D009955:Ornithine Decarboxylase