[Modifying effects of ascorbic acid on nitrosodimethylamine-induced carcinogenesis].
In chronic experiments, albino noninbred rats were fed 20.0, 2.0 or 0.2 mg/l nitrosodimethylamine and 1000 or 100 mg/l ascorbic acid (average daily dose 100 or 10 mg/kg body weight). The study established the modifying effect of ascorbic acid on nitrosodimethylamine -- induced carcinogenesis. A decrease in tumor incidence was observed, particularly, at high level of the carcinogen. High dose ascorbic acid did not affect tumor incidence in intact animals; however, time to detection of the first tumor and mean duration of tumor development proved longer.
Benemanskiĭ
V V
VV
Katul'skiĭ
Iu N
IuN
Levina
V Ia
VIa
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D004128:Dimethylnitrosamine; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D013997:Time Factors
D004128:Dimethylnitrosamine; D001205:Ascorbic Acid
Modifitsiruiushchee vliianie askorbinovoĭ kisloty na kantserogenez, vyzvannyĭ nitrozodimetilaminom.