Effect of bifemelane hydrochloride on an injury of the liver caused by ischemia-reperfusion in rats.
In the liver ischemia-reperfusion model, the lipid peroxide level increased during ischemic periods, while a greater increase was observed during reflow periods. The increase in the cytochrome b5 content was observed during ischemia and reflow periods. On the contrary, the cytochrome P-450 content remained unchanged during ischemic periods, but decreased during reflow periods. Bifemelane suppressed the elevation of the lipid peroxide level, the cytochrome b5 content and the decrease in cytochrome P-450 content during the period of reperfusion.
Nagai
T
T
Department of Pharmacology, Medical College of Oita, Japan.
Egashira
T
T
Yamanaka
Y
Y
D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D007511:Ischemia / Q000150:complications; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000188:drug therapy*
D001559:Benzhydryl Compounds; D008054:Lipid Peroxides; D008315:Malondialdehyde; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; C031906:bifemelane