[The effect of acetazolamide-induced, endogenous volume stress of the cerebrospinal system on intracranial pressure. Diamox--effect on intracranial pressure].
In 16 patients with possible disturbed CSF circulation longterm recording of intracranial pressure (ICP) was performed. In 9 of the 16 patients the disorder became evident after the application of an exogenous volume-pressure testing procedure. This procedure enabled a classification into a group I--disturbed CSF circulation (8 patients)--and another group II--normal CSF circulation (8 patients). During a routine Xenon-CT-CBF study all patients of both groups were given to 1 g acetazolamide (DIAMOX) intravenously. Before, during and after the administration of DIAMOX the epidural ICP was continuously measured. An increase in ICP was monitored in all patients. In group I the average initial ICP was 13.6 +/- 7.6 mmHg. The maximum ICP was reached within a time interval of 13.1 +/- 4.5 min after DIAMOX administration. At this time the mean ICP was 36.4 +/- 19.2 mmHg (p less than 0.01). The average initial ICP in group II was 6.3 +/- 4.2 mmHg. The maximum ICP was reached within a time interval of 13.6 +/- 1.1 min. At this time the mean ICP was 11.9 +/- 4.8 mmHg (p less than 0.01). In respect to the maximum ICP both groups were significantly different (p less than 0.01). Despite a considerably rising ICP up to values of about 50 to 70 mmHg in several patients of group I only 1 patient complained of being sick. Presumingly, an ICP elevation caused by vasodilatation would be better tolerated than ICP elevations due to other causes.
Holl
K
K
Neurochirurgische Klinik, Medizinischen Hochschule Hannover.
Heissler
H E
HE
Nemati
N
N
Gaab
M R
MR
Haubitz
B
B
Becker
H
H
D000086:Acetazolamide / Q000008:administration & dosage / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier / Q000187:drug effects; D002557:Cerebrospinal Fluid Shunts; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D014664:Vasodilation / Q000187:drug effects
D000086:Acetazolamide
Die Wirkung der Acetazolamid-induzierten, endogenen Volumenbelastung des zerebrospinalen Systems auf den intrakraniellen Druck. DIAMOX--Wirkung auf den intrakraniellen Druck (ICP).