The cholinesterase inhibitor soman increases inositol trisphosphate in rat brain.
Studies were conducted to determine the effect of the cholinesterase inhibitor soman on the amount of inositol trisphosphate in the neocortex, striatum, cerebellum, and medulla-pons regions of rat brain in vivo. The studies indicate that treatment with soman increases inositol trisphosphate in the neocortex and striatum, but not in the cerebellum or medulla-pons region. In the neocortex the most pronounced increases were observed in animals with severe poisoning symptoms, however inositol trisphosphate was also found to be elevated in animals with only mild poisoning symptoms.
Mobley
P L
PL
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D007292:Inosine Nucleotides / Q000378:metabolism*; D007293:Inosine Triphosphate / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000494:pharmacology* / Q000506:poisoning; D013268:Stimulation, Chemical
D007292:Inosine Nucleotides; D007293:Inosine Triphosphate; D012999:Soman