Severity of cirrhosis and the relationship of alpha 1-acid glycoprotein concentration to plasma protein binding of lidocaine.
The concentration of alpha 1-acid glycoprotein, the major determinant of the plasma protein binding of basic drugs, and the extent of lidocaine protein binding was related to the severity of liver disease in 30 cirrhotic patients. In comparison with matched control subjects, alpha 1-acid glycoprotein concentration (77 +/- 7 versus 37 +/- 3 mg/dl; mean +/- SEM; p less than 0.01) and lidocaine binding (69% +/- 2% versus 35% +/- 2%; p less than 0.01) was markedly reduced. There was a significant negative correlation (r = 0.78; p less than 0.01) between free lidocaine and alpha 1-acid glycoprotein concentration. Furthermore, both were significantly related to the severity of liver disease, as assessed by use of the Child Turcotte classification.
Barry
M
M
Department of Pharmacology, Trinity College Medical School, St. James's Hospital, Dublin, Ireland.
Keeling
P W
PW
Weir
D
D
Feely
J
J
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008012:Lidocaine / Q000378:metabolism*; D008099:Liver / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D011485:Protein Binding
D001798:Blood Proteins; D009961:Orosomucoid; D008012:Lidocaine