Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach.
It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP.
Holzer
P
P
University of Bochum Department of Experimental Clinical Medicine, Bochum, F.R.G.
Peskar
B M
BM
Peskar
B A
BA
Amann
R
R
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects
D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin