Effects of coenzyme Q10 in hemorrhagic shock.
We studied the effects of coenzyme Q10 (CoQ10) on pulmonary function and chemical mediators in a canine model of hemorrhagic shock. One group received 10 mg/kg of CoQ10 before hemorrhage. During the study, percent change from baseline of peak airway pressure, total lung compliance of the lung and chest wall, and blood lactate levels appeared to be significantly smaller in dogs pretreated with CoQ10 than in controls. Furthermore, CoQ10 was found to maintain blood histamine levels and to attenuate the increase in leukotriene C4. The mechanism of the beneficial effects of CoQ10 in hemorrhagic shock is presently unknown, but our data suggest that it may be useful in the treatment of hemorrhagic shock.
Yamada
M
M
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001784:Blood Gas Analysis; D003067:Coenzymes; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006632:Histamine / Q000097:blood; D007773:Lactates / Q000097:blood; D008170:Lung Compliance / Q000187:drug effects; D012123:Pulmonary Ventilation / Q000187:drug effects; D013189:SRS-A / Q000097:blood; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
D003067:Coenzymes; D007773:Lactates; D013189:SRS-A; D014451:Ubiquinone; D006632:Histamine; C024989:coenzyme Q10