title: Stress activation of limbic and cortical dopamine release is prevented by ICS 205-930 but not by diazepam.
abstract: Systemic administration of the 5-HT3 receptor antagonist ICS 205-930, but not of the benzodiazepine diazepam, was able to prevent the stimulation of dopamine release in the nucleus accumbens and prefrontal cortex induced by restraint stress. These findings suggest that stress is not simply co-extensive with anxiety and that 5-HT3 receptors could regulate the dopaminergic response to stress.
authors.affiliation: Istituto di Farmacologia Medica 2nda Cattedra, Università La Sapienza, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Imperato
authors.forename: S
authors.initials: S
authors.lastname: Puglisi-Allegra
authors.forename: A
authors.initials: A
authors.lastname: Zocchi
authors.forename: M G
authors.initials: MG
authors.lastname: Scrocco
authors.forename: P
authors.initials: P
authors.lastname: Casolini
authors.forename: L
authors.initials: L
authors.lastname: Angelucci
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013312:Stress, Physiological / Q000378:metabolism*; D000077526:Tropisetron
chemical_list: D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron; D003975:Diazepam; D004298:Dopamine