Changes in boron concentration during development and ageing of Drosophila and effect of dietary boron on life span.
Total boron concentrations in Drosophila changed during development and ageing. The highest concentration of boron was found during the egg stage followed by a decline during the larval stages. Newly emerged flies contained 35.5 ppm boron. During the adult stage the boron concentration increased by 52% by 9 weeks of age. Adding excess dietary boron during the adult stage decreased the median life span by 69% at 0.01 M sodium borate and by 21% at 0.001 M sodium borate. Lower concentrations gave small but significant increases in life span. Supplementing a very low boron diet with 0.00025 M sodium borate improved life span by 9.5%. The boron contents of young and old mouse tissues were similar to those of Drosophila and human samples. We conclude that moderate levels of dietary boron may have a general protective effect in biological systems. The mechanism of this effect at present remains unknown.
Massie
H R
HR
Masonic Medical Research Laboratory, Utica, New York 13501.
Whitney
S J
SJ
Aiello
V R
VR
Sternick
S M
SM
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001895:Boron / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D004032:Diet; D004330:Drosophila / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D008136:Longevity / Q000187:drug effects; D008297:Male; D051379:Mice; D014018:Tissue Distribution
D001895:Boron