[The radioprotective action of suprofen].
Suprofen is a new non-steroidal anti-inflammatory drug administered intragastrically 90 min before roentgen irradiation in a dose of 20 mg/kg and then daily for 10 days in a dose of 10 mg/kg exerts the radioprotective effect evaluated according to a 30-day survival rate and an average life expectancy of the deceased animals as well as according to a decrease of postirradiation leukopenia incidence. A single administration of suprofen following roentgen irradiation exerts no radioprotective effect. Suprofen was found to enhance the radioprotective action of cysteamine.
Maćkowiak
J
J
Sierakowski
S
S
Wiśniewski
K
K
D000818:Animals; D003538:Cystamine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000401:mortality; D011837:Radiation-Protective Agents; D051381:Rats; D011919:Rats, Inbred Strains; D013496:Suprofen / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D013496:Suprofen; D003538:Cystamine
Radiozashchitnoe deĭstvie suprofena.