title: The metabolism of (+-)-methylephedrine in rat and man.
abstract: 1. Urinary metabolites of methylephedrine and their excretion after oral administration to rat and human volunteers have been studied. 2. The unchanged drug, ephedrine, norephedrine, their aromatic hydroxylated compounds and methylephedrine N-oxide were found in rat urine. The same metabolites, except the p-hydroxylated metabolites, were detected in human urine. The most abundant metabolite in rat urine was methylephedrine N-oxide, and in human urine was the unchanged drug. 3. Metabolites excreted in three days after administration of the drug to rat amounted to about 54% of the dose and those after administration to man, 70-72%.
authors.affiliation: National Research Institute of Police Science, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004809:Ephedrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D015262:Xenobiotics
chemical_list: D015262:Xenobiotics; C041707:N-methylephedrine; D004809:Ephedrine