[Changes in the activity of granulocytopoiesis during increasing and reducing the reactions of the lysosomal apparatus of circulating neutrophils in hypovolemic hypotension].
An interrelation between the intensity of release of the lysosomal content of circulating neutrophils and the activation degree of granulocytopoiesis and neutrophilia was revealed by means of pharmacological influence on the lysosomal membrane stability in case of hypovolemic hypotension in rabbits. The activation of granulocytopoiesis and neutrophilia increased while intensifying the release of lysosomal factors from the circulating neutrophils and sharply decreased while restricting it. The intensity of hypotension decreased while intensifying the reaction of the lysosomal apparatus of circulating neutrophils and increased while depressing the reaction.
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D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D001815:Bloodletting; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D006470:Hemorrhage / Q000503:physiopathology*; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007958:Leukocyte Count; D008247:Lysosomes / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D011817:Rabbits
Izmeneniia aktivnosti granulotsitopoeza pri usilenii i oslablenii reaktsii lizosomal'nogo apparata tsirkuliruiushchikh neĭtrofilov v usloviiakh gipovolemicheskoĭ gipotenzii.