Clofibrate raises human 24 h intragastric acidity but does not affect plasma gastrin concentration.
1. We studied the effects of acute oral dosing with clofibrate (500 mg four times daily) on 24 h intragastric acidity and plasma gastrin concentration in 12 healthy female subjects. 2. The 24 h integrated intragastric acidity rose from 429 mmol l-1 h (95% CI 296-479) before dosing to 527 mmol l-1 h (95% CI 385-664) on the day of dosing (+23%; P = 0.041), but no change was observed in the 24 h integrated plasma gastrin concentration: 420 pmol l-1 h (95% CI 282-499) before and 389 pmol l-1 h (95% CI 249-489) during dosing (P = 0.182). 3. We conclude that clofibrate has no acute antisecretory effect on the human stomach, and that human gastrin-induced enterochromaffin-like cell proliferation is unlikely with this drug.
Gavey
C J
CJ
Academic Department of Medicine, Royal Free Hospital School of Medicine, London.
Smith
J T
JT
Nwokolo
C U
CU
Pounder
R E
RE
D000328:Adult; D002994:Clofibrate / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans
D005755:Gastrins; D002994:Clofibrate