Prevalence of oral lesions among HIV-infected intravenous drug abusers and other risk groups.
To study the prevalence of oral manifestations, we examined 217 patients infected with the human immunodeficiency virus (HIV). Most of our patients were intravenous drug abusers (IVDAs) (65%). Other risk categories were represented by IVDAs who were also male homosexuals or bisexuals (11%), male homosexuals and bisexuals (16%), sexual partners of HIV-infected patients (5%), and hemophilic persons and recipients of blood transfusions (3%). Forty-six patients were women and 171 were men, with a median age of 27 years (range, 11 to 65 years). At the time of first examination, 38% of patients had asymptomatic HIV infection, 36% had lymphadenopathy syndrome, 17% had AIDS-related complex, and 9% had AIDS. Oral manifestations were observed in 89 (41%) patients. Of these, 15 had asymptomatic infection, 23 had lymphadenopathy syndrome, 27 had AIDS-related complex, and 24 had AIDS. Increasing severity of disease was significantly associated with higher prevalence of oral lesions (p less than or equal to 0.0001). Candidiasis was the most common oral lesion, followed by hairy leukoplakia. Kaposi's sarcoma, melanotic macules, herpes labialis, condyloma acuminatum, perioral molluscum contagiosum, and bacterial glossitis due to Escherichia coli infection were found in a small number of patients. Results of culture for fungi, available for 203 patients, revealed that 51% of patients with positive Candida cultures had clinical evidence of candidiasis. Our study demonstrates that oral lesions are also important signs of HIV infection among IVDAs. Early diagnosis of these manifestations is becoming increasingly significant in the practice of dentistry.
Barone
R
R
Division of Maxillofacial Surgery, University of Florence, Italy.
Ficarra
G
G
Gaglioti
D
D
Orsi
A
A
Mazzotta
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001727:Bisexuality; D002180:Candidiasis, Oral / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006716:Homosexuality; D006801:Humans; D007558:Italy; D007972:Leukoplakia, Oral / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000453:epidemiology* / Q000209:etiology; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000209:etiology; D015819:Substance Abuse, Intravenous / Q000150:complications*