Respiratory system mechanics in guinea pigs after acute hemorrhage: role of adrenergic stimulation.
We evaluated the effects of acute blood loss on the respiratory mechanics of guinea pigs. We measured respiratory system elastance (Ers) and resistance (Rrsmax) using the end-inflation occlusion method. Rrsmax was partitioned into its homogeneous component (Rrsmin) and that due to the unevenness within the respiratory system (Rrsu). Respiratory mechanics were studied both before and immediately after bleeding in eight animals. Another eight guinea pigs had received propranolol previously and were also submitted to hemorrhage. Propranolol-treated animals showed higher control values of Rrsmax (p less than .02) and Rrsmin (p less than .0001). Animals not treated with propranolol exhibited a decrease (p less than 0.001) in Rrsmax after hemorrhagic hypovolemia (from 0.375 +/- 0.051 to 0.323 +/- 0.042 cm H2O/ml.sec), due to a decrease (p less than 0.005) in Rrsmin (from 0.140 +/- 0.031 to 0.094 +/- 0.032 cm H2O/ml.sec), whereas Ers and Rrsu did not change. Propranolol-treated animals showed an increase (p less than .001) in Rrsmax (from 0.512 +/- 0.133 to 0.664 +/- 0.144 cm H2O/ml.sec), Rrsu (p less than 0.01) from 0.252 +/- 0.09 to 0.345 +/- 0.139 cm H2O/ml.sec, and Ers (p less than 0.001) (from 4.565 +/- 0.933 to 5.402 +/- 1.24 cm H2O/ml) after bleeding. The results indicate that the immediate effects of acute bleeding on respiratory mechanics are significantly influenced by catecholamines.
Martins
M A
MA
Laboratório de Poluição Atmosférica Experimental, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Zin
W A
WA
Younes
R N
RN
Negri
E M
EM
Sakae
R S
RS
Lin
C A
CA
Hoelz
C
C
Auler Júnior
J O
JO
Saldiva
P H
PH
D000403:Airway Resistance / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D002395:Catecholamines / Q000097:blood / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D008170:Lung Compliance / Q000187:drug effects* / Q000502:physiology; D008176:Lung Volume Measurements; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*
D002395:Catecholamines; D011433:Propranolol