[Acute renal failure with high-dose combination therapy with penicillin G and amoxicillin].
A 3 year old girl was admitted with suspected bacterial meningitis. The patient's history concerning renal and cerebral function and known allergies had been uneventful until that time. 36 h after initiation of a high dose antibiotic therapy with Penicillin G (0.5 Mega IE/kg/day) and Amoxicillin (400 mg/kg/day) macrohematuria and consecutive anuria was observed. Prerenal cardiocirculatory failure, a Schwartz-Bartter-reaction as well as coagulatory failure could be ruled out. There were no symptoms of hypersensitivity. Sonographic examinations of the kidneys and the urinary tract as well as urinanalysis suggested an acute tubular obstruction and papillary necrosis caused by amoxicillin. After changing the antibiotic regimen to chloramphenicol and induction of diuresis by furosemide and dopamine renal failure could be resolved within 39 h. The patient recovered completely. High dose therapy with amoxicillin (greater than 300 mg/kg/day) includes the risk of tubular obstruction due to cristalluria. Solubility of ampicillin in aqueous fluids (6.5 mg/ml at pH 7) should be supported by sufficient diuresis and urine alkalization.
Tegtmeyer
F K
FK
Klinik für Pädiatrie, Medizinischen Universität Lübeck.
Otte
J
J
Thyen
U
U
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000658:Amoxicillin / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008581:Meningitis / Q000188:drug therapy*; D010400:Penicillin G / Q000009:adverse effects* / Q000627:therapeutic use
D000658:Amoxicillin; D010400:Penicillin G
Akutes Nierenversagen unter hochdosierter Kombinationstherapie mit Penicillin G and Amoxicillin.