title: Melanin-concentrating hormone: a structural and conformational study based on synthesis, biological activity, high-field NMR, and molecular modeling techniques.
abstract: A series of Melanin-concentrating hormone (MCH) fragments have been synthesized and their biological activities compared with the parent peptide. The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies. Conformational features predicted by molecular dynamics analyses find support in the nmr experiments.
authors.affiliation: University of Bath, Avon, England.
authors.forename: D W
authors.initials: DW
authors.lastname: Brown
authors.forename: M M
authors.initials: MM
authors.lastname: Campbell
authors.forename: R G
authors.initials: RG
authors.lastname: Kinsman
authors.forename: P D
authors.initials: PD
authors.lastname: White
authors.forename: C A
authors.initials: CA
authors.lastname: Moss
authors.forename: D J
authors.initials: DJ
authors.lastname: Osguthorpe
authors.forename: P K
authors.initials: PK
authors.lastname: Paul
authors.forename: B I
authors.initials: BI
authors.lastname: Baker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D007028:Hypothalamic Hormones; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008543:Melanins / Q000138:chemical synthesis / Q000502:physiology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010907:Pituitary Hormones / Q000138:chemical synthesis / Q000502:physiology; D011487:Protein Conformation
chemical_list: D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone