Actions of platelet-activating factor on isolated feline and human cerebral arteries.
The effects of platelet-activating factor (PAF) were studied on isolated feline basilar arteries (BAs) and human pial arteries (PAs). PAF contracted the BAs by 67% of the contraction induced by 124 mM K+ and the PAs by 80%. The contraction in BAs was unaffected by both indomethacin and the thromboxane receptor antagonist AH23848. PAF relaxed prostaglandin F2 alpha-contracted arteries. In BAs 10(-6) M PAF reduced the contraction by 17% and in PAs by 47%. The relaxant effects in both arteries were unaffected by indomethacin. In conclusion, PAF can act both as a constrictor and as a dilator of isolated feline and human cerebral arteries. The effects are seemingly unrelated to vascular prostanoid production.
Uski
T K
TK
Department of Clinical Pharmacology, University Hospital of Lund, Sweden.
Reinstrup
P
P
D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D006801:Humans; D010972:Platelet Activating Factor / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D010972:Platelet Activating Factor