Hepatic failure associated with imipramine therapy.
Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11-year-old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation.
Shaefer
M S
MS
Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha.
Edmunds
A L
AL
Markin
R S
RS
Wood
R P
RP
Pillen
T J
TJ
Shaw
B W
BW
D002648:Child; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007099:Imipramine / Q000009:adverse effects* / Q000627:therapeutic use; D007427:Intracranial Pressure / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male
D007099:Imipramine