title: Surgical treatment for infarct-related ventricular septal defects. Improved early results combined with analysis of late functional status.
abstract: A total of 101 patients (mean age 64.9 years) underwent surgical correction of postinfarction ventricular septal defect at this institution over a 15-year period (1973 to 1988). The overall early mortality rate was 20.8%, although the most recent experience with 36 patients (January 1987 to October 1988) has seen this decline to 11.1%. Factors found to influence early death significantly, when analyzed univariately, were as follows: (1) site of infarction (anterior 12.1%, inferior 32.6%, p = 0.02); (2) time interval between infarction and operation (less than 1 week 34.1%, greater than 1 week 10.5%, p = 0.008); (3) cardiogenic shock (present 38.1%, absent 8.5%, p = 0.001). Nonsignificant variables included preoperative renal function, age, and concomitant coronary artery bypass, although older age (greater than 65 years) became significant when examined in a multivariate fashion. Of the 80 hospital survivors, eight were subsequently found to have a recurrent or residual defect necessitating reoperation, with survival in seven. Late follow-up is 99% complete and reveals an actuarial survival rate for 100 patients of 71.1% at 5 years (95% confidence interval 60.6 to 80.0), and 40.0% at 10 years (95% confidence interval 21.7 to 58.4). A significant recent change in policy of not using coronary angiography in patients with a ventricular septal defect caused by anterior wall infarction has not resulted in any increase in either the early mortality or in the late prevalence of angina. The functional status of 38 surviving patients has been analyzed by a graded treadmill exercise protocol, whereas left ventricular functional assessment was by nuclear scan with additional information on mitral valve function by echocardiogram. Color Doppler flow mapping has been used to determine the presence of a residual defect. Most late survivors have limited exercise tolerance related to both cardiac and noncardiac factors. Left ventricular function is moderately impaired (mean ejection fraction = 0.39). However, many patients are elderly and have adapted to their residual symptoms without significant changes in life-style.
authors.affiliation: Wessex Cardiothoracic Centre, Southampton General Hospital, England.
authors.forename: P D
authors.initials: PD
authors.lastname: Skillington
authors.forename: R H
authors.initials: RH
authors.lastname: Davies
authors.forename: A J
authors.initials: AJ
authors.lastname: Luff
authors.forename: J D
authors.initials: JD
authors.lastname: Williams
authors.forename: K D
authors.initials: KD
authors.lastname: Dawkins
authors.forename: N
authors.initials: N
authors.lastname: Conway
authors.forename: R K
authors.initials: RK
authors.lastname: Lamb
authors.forename: D F
authors.initials: DF
authors.lastname: Shore
authors.forename: J L
authors.initials: JL
authors.lastname: Monro
authors.forename: J K
authors.initials: JK
authors.lastname: Ross
mesh_terms: D000367:Age Factors; D000368:Aged; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006341:Heart Rupture / Q000601:surgery*; D006342:Heart Rupture, Post-Infarction / Q000503:physiopathology / Q000601:surgery*; D006346:Heart Septum / Q000293:injuries / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality*; D012008:Recurrence; D012307:Risk Factors; D015996:Survival Rate