title: Bioequivalence of two pharmaceutical forms of diltiazem.
abstract: Diltiazem, a calcium-channel blocking agent, has been shown to be a potent coronary vasodilator used in the treatment of ischaemic heart disease. The present study was conducted to compare the bioavailability of regular 60 mg tablets administered every 6 h with sustained release capsules of 120 mg administered every 12 h. High-performance liquid chromatographic analysis was carried out for determination of diltiazem and one of its metabolites desacetyldiltiazem in six male patients. The relative bioavailability of this sustained-release pharmaceutical form did not show any significant difference with that of tablets.
authors.affiliation: School of Pharmacy and Biochemistry, Buenos Aires University, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Rubio
authors.forename: M I
authors.initials: MI
authors.lastname: Masana
authors.forename: E
authors.initials: E
authors.lastname: Garcilazo
authors.forename: A R
authors.initials: AR
authors.lastname: de los Santos
authors.forename: G
authors.initials: G
authors.lastname: di Girolamo
mesh_terms: D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D013607:Tablets; D013810:Therapeutic Equivalency
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D013607:Tablets; D004110:Diltiazem