Identification of two human ferritin H genes on the short arm of chromosome 6.
We have found by analyses of human-hamster hybrid cells that two human ferritin H genes lie near the locus of the iron storage disease idiopathic hemochromatosis on chromosome 6p. One of these genes was isolated and shown to be a processed pseudogene. Comparison of its sequence with those of other ferritin H pseudogenes indicates that they may be derived from a functional H gene other than that on chromosome 11.
Dugast
I J
IJ
Department of Biochemistry, Tufts University, Boston, Massachusetts 02111.
Papadopoulos
P
P
Zappone
E
E
Jones
C
C
Theriault
K
K
Handelman
G J
GJ
Benarous
R
R
Drysdale
J W
JW
D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D005293:Ferritins / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006432:Hemochromatosis / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D011544:Pseudogenes; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D004247:DNA; D005293:Ferritins