Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels.
Sulfonylurea-sensitive adenosine triphosphate (ATP)-regulated potassium (KATP) channels are present in brain cells and play a role in neurosecretion at nerve terminals. KATP channels in substantia nigra, a brain region that shows high sulfonylurea binding, are inactivated by high glucose concentrations and by antidiabetic sulfonylureas and are activated by ATP depletion and anoxia. KATP channel inhibition leads to activation of gamma-aminobutyric acid (GABA) release, whereas KATP channel activation leads to inhibition of GABA release. These channels may be involved in the response of the brain to hyper- and hypoglycemia (in diabetes) and ischemia or anoxia.
Amoroso
S
S
Institut de Pharmacologie Moléculaire et Cellulaire, UPR 411 du CNRS, Valbonne, France.
Schmid-Antomarchi
H
H
Fosset
M
M
Lazdunski
M
M
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D015687:Cell Hypoxia; D003847:Deoxyglucose / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D009840:Oligomycins / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D012413:Rubidium / Q000378:metabolism; D013329:Structure-Activity Relationship; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D007004:Hypoglycemic Agents; D009840:Oligomycins; D015221:Potassium Channels; D005680:gamma-Aminobutyric Acid; D000255:Adenosine Triphosphate; D003847:Deoxyglucose; D005947:Glucose; D012413:Rubidium; D011188:Potassium