Comparison of clinic and home blood pressure levels and the role of the sympathetic nervous system in clinic-home differences.
Plasma and urine norepinephrine, epinephrine and home blood pressure were measured in 48 young hypertensive men (mean age, 21 years) and 25 matched normotensive controls. Plasma samples were drawn following 30 min rest in the clinic and 24 h urine samples were collected at home. Twenty-one hypertensive patients were given a single dose of clonidine (150 micrograms orally). Changes in blood pressure, heart rate and plasma norepinephrine were assessed. Twenty-five of the hypertensive patients were found to have a normal home blood pressure (defined from records of the normotensive subjects). The other group of patients maintained a high home blood pressure. In comparison to normal subjects, patients with a high home blood pressure were characterized by higher urinary norepinephrine and epinephrine excretion and higher plasma epinephrine. Patients with a normal home blood pressure had normal heart rate at home, normal plasma and urinary catecholamines. However, the two groups of hypertensives could not be distinguished on the basis of clinic blood pressure, plasma or urinary catecholamines due to considerable overlap. At 90 min after oral clonidine administration, the plasma norepinephrine and blood pressure levels were decreased in both groups of hypertensives to a similar extent. The changes in heart rate were significantly smaller in patients with a high home blood pressure than in those with a normal home blood pressure. These results suggest that the patients with a high home blood pressure tended to have a high sympathetic nerve activity. However, the two groups of hypertensives could not be separated on the basis of plasma or urinary catecholamine measurements.
Saito
I
I
Department of Internal Medicine, Keio University, Tokyo, Japan.
Takeshita
E
E
Hayashi
S
S
Takenaka
T
T
Murakami
M
M
Saruta
T
T
Nagano
S
S
Sekihara
T
T
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000554:Ambulatory Care Facilities; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004837:Epinephrine / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000503:physiopathology
D003000:Clonidine; D009638:Norepinephrine; D004837:Epinephrine