Contact depigmentation from free para-tertiary-butylphenol in bindi adhesive.
100 consecutive cases of contact depigmentation due to bindi during a period of 11 months were studied. Bindi adhesive material was found to contain 80% para-tertiary-butylphenol (PTBP), by thin-layer chromatography, infrared spectrophotometry and high-pressure liquid chromatography. The possibility of hypersensitivity to PTBP was ruled out as none of the 15 patients tested with 2% PTBP and 1% para-tertiary-butylphenol-formaldehyde resin gave any positive reactions. Development of depigmentation could have been due either to individual susceptibility or to constant use for a prolonged period. The area of contact being very small, generalised vitiligo as a result of systemic absorption appeared to be a remote possibility.
Bajaj
A K
AK
Department of Dermatology and Pathology, MLN Medical College, Uttar Pradesh, India.
Gupta
S C
SC
Chatterjee
A K
AK
D000269:Adhesives / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010328:Patch Tests / Q000379:methods; D010636:Phenols / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced*
D000269:Adhesives; D010636:Phenols; C006862:butylphen