Effect of oral cadmium exposure during pregnancy on maternal and fetal zinc metabolism in the rat.
To study the effect of cadmium exposure on maternal and fetal zinc metabolism, rats were exposed to 0, 5, 50, or 100 ppm Cd in the drinking water on Days 6 through 20 of pregnancy. In comparison to controls, fetal and maternal weights were slightly reduced in the 50- and 100-ppm groups, but not the 5-ppm group. Multiple regression analysis revealed that in the 50-ppm group, but not in the 100-ppm group, the decrease in fetal weight was not solely a consequence of decreased maternal weight. Cd accumulated in a dose-dependent manner in both maternal organs and fetuses, although the absolute concentrations in fetuses were very low as compared to those of maternal tissues. In the 50- and 100-ppm groups, zinc concentrations were significantly increased in maternal liver and kidney, and significantly decreased in fetal liver. The changes in tissue Zn concentrations were accompanied by altered Zn-metalloenzyme activities in both maternal and fetal tissues. These findings support the hypothesis that Cd-induced maternal zinc retention is responsible for fetal Zn deprivation and impaired fetal growth.
Sorell
T L
TL
Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Graziano
J H
JH
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000201:enzymology; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism*
D006454:Hemoglobins; D002104:Cadmium; D006867:Hydrolases; D000469:Alkaline Phosphatase; D000623:Porphobilinogen Synthase; D015032:Zinc