Fatal submassive necrosis of the liver associated with piroxicam.
A 64-yr-old woman developed acute hepatitis after 3 wk of treatment with 40 mg/day of piroxicam (Feldene). Jaundice was preceded by a skin rash associated with eosinophilia. Despite withdrawal of the drug, she developed severe hepatocellular failure and died 53 days after the onset. Hepatitis was attributed to piroxicam because of the absence of other etiological factors.
Planas
R
R
Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol de Badalona, Spain.
De León
R
R
Quer
J C
JC
Barranco
C
C
Bruguera
M
M
Gassull
M A
MA
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008875:Middle Aged; D009336:Necrosis; D010149:Postoperative Pain / Q000188:drug therapy; D010894:Piroxicam / Q000009:adverse effects* / Q000627:therapeutic use
D010894:Piroxicam