Comparison of 2-drug and 3-drug immunosuppression for cadaveric renal transplantation.
We compare the results in recipients of cadaveric renal allografts immunosuppressed with cyclosporine and prednisone to those who received immunosuppression with cyclosporine, azathioprine and prednisone. The 2 groups were compared relative to HLA-ABDR matching, plasma reactive antibodies, cold ischemia time, diabetes as a cause of renal failure and recipient age greater than 50 years. The incidences of clinical allograft rejection and grafts lost to rejection were not significantly different in these 2 groups evaluated at 1 year. In the 2-drug immunosuppressed group the actual 3, 6 and 12-month graft function was 87, 86 and 85%, respectively, compared to 79, 78 and 74%, respectively, in the 3-drug immunosuppressed group. A difference in graft survival was due to graft loss secondary to vascular thrombosis and patient death, and not to immunological events. No advantage was demonstrated for the use of 3-drug immunosuppression for kidney allografts over a 2-drug protocol of cyclosporine and prednisone.
Martin
D C
DC
Department of Surgery, University of California Irvine.
Tertzakian
G
G
Ruzics
E
E
D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D003524:Cyclosporins / Q000627:therapeutic use; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
D003524:Cyclosporins; D006680:HLA Antigens; D001379:Azathioprine; D011241:Prednisone