title: The effect of taurine supplementation on the ototoxicity of neomycin in guinea pigs.
abstract: Experiments have been performed to examine the effects of taurine supplementation on the ototoxicity of neomycin. It was found that concurrent administration of taurine and neomycin produced a greater degree of ototoxicity, as evidenced by increases in hearing thresholds, than with neomycin alone. The results are discussed in light of a recently proposed mechanism of aminoglycoside ototoxicity.
authors.affiliation: Department of Pharmacology, Medical School, University of Birmingham, England.
authors.forename: I S
authors.initials: IS
authors.lastname: Kay
authors.forename: W E
authors.initials: WE
authors.lastname: Davies
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D001923:Brain Chemistry; D004357:Drug Synergism; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced* / Q000503:physiopathology; D009355:Neomycin / Q000633:toxicity*; D013654:Taurine / Q000032:analysis / Q000633:toxicity*
chemical_list: D013654:Taurine; D009355:Neomycin