Glycose aminoglycane excretion and concentration in the urine of patients with frequently recurrent calcium-oxalate lithiasis prior to and following Diclofenac-Na therapy.
Excretion and concentration of glycose aminoglycans were measured in 19 patients with frequent relapses of calcium-oxalate lithiasis, prior to and two weeks after onset of Diclofenac-Na therapy. In most patients, markedly enhanced glycose aminoglycan concentration and excretion could be demonstrated. Elevation of the high-molecular inhibitor potential in the urine results in reduced risk of calcium-oxalate lithogenesis, which may explain the therapeutic success of nonsteroidal anti-inflammatory drugs in the treatment of therapy resistant calcium-oxalate lithiasis.
Brundig
P
P
Clinic and Outpatient Department of Urology, Friedrich Schiller University, Jena, GDR.
Börner
R H
RH
Haerting
R
R
Janitzky
V
V
Schlichter
A
A
D002129:Calcium Oxalate / Q000652:urine*; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014545:Urinary Calculi / Q000188:drug therapy* / Q000652:urine
D006025:Glycosaminoglycans; D004008:Diclofenac; D002129:Calcium Oxalate