title: [Cardiac side effects of 5-fluorouracil].
abstract: In four patients (a 54-year-old man and three women aged 57, 60 and 65 years, respectively) with colorectal carcinoma and no obvious cardiac abnormality anginal symptoms and ECG changes occurred during chemotherapy with 5-fluorouracil at a dose of 400 and 600 mg/m2. The ECG changes consisted of descending ST depressions with preterminally negative T waves, terminally negative T waves, ventricular extrasystoles and sinus tachycardia with intermittent atrial fibrillation. The signs first appeared between the second and fourth day of treatment; in two patients they improved with glyceryl trinitrate. A few days after 5-fluorouracil had last been administered all ECG changes had disappeared. The causes of cardiotoxicity of the drug remain unknown.
authors.affiliation: Innere Klinik und Poliklinik, Universitätsklinikum Essen.
authors.forename: D
authors.initials: D
authors.lastname: May
authors.forename: U
authors.initials: U
authors.lastname: Wandl
authors.forename: R
authors.initials: R
authors.lastname: Becher
authors.forename: N
authors.initials: N
authors.lastname: Niederle
authors.forename: C G
authors.initials: CG
authors.lastname: Schmidt
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D015179:Colorectal Neoplasms / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005472:Fluorouracil
vernacular_title: Kardiale Nebenwirkungen von 5-Fluorouracil.