Immunostaining of antral gastrin cells is quantitatively increased in Heliobacter pylori gastritis.
The amount of gastrin-like immunostaining in gastrin (G) cells of the antral mucosa was quantified using a computer-assisted method of measuring immunoreaction product. Biopsies from 25 patients without Heliobacter-like organisms and 60 patients with varying degrees of infection were immunostained for gastrin. Twenty-five G cells from each patient were measured both subjectively and by image analysis. Gastrin-like immunoreactivity was found to be significantly increased in the presence of Heliobacter-like organisms.
Sankey
E A
EA
Department of Histopathology, Royal Free Hospital, London, UK.
Helliwell
P A
PA
Dhillon
A P
AP
D001706:Biopsy; D002169:Campylobacter Infections / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000378:metabolism*; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry
D005755:Gastrins