[Cytodynamic evaluation on the relationship between the mode of intracellular DNA content and the prognosis of esophageal cancer patients].
In order to elucidate biological features of esophageal carcinoma influencing the prognosis of patients, intracellular DNA content was determined using a flow-cytometry (FCM) apparatus. DNA ploidy patterns in 112 paraffin-embedded specimens removed at surgery were classified into 4 categories according to the shape of the first peak curve and the presence of the second peak curve. Type A: with symmetric single peak curve. (euploidy type) Type B: with asymmetric single peak curve. Type C: with the second small peak curve appearing on the right side of the first peak curve. Type D: with two obvious peak curves. Type B, C and D were grossly included in aneuploidy type, because of the presence of abnormal stem line. These DNA ploidy patterns were well correlated with histologic types. There were, however no significant differences in the relationship of DNA ploidy patterns and clinical stages. Four-year survival rate of the patients with euploidy pattern was 65.5%, and that with aneuploidy pattern was 15.7%, indicating a significant difference in survival between patients with the former pattern and those with the latter. The type of DNA ploidy was considered as one of the important prognostic indicators in patients with esophageal carcinoma independent of any other pathologic factors.
Hasegawa
M
M
Department of Surgery, Niigata University School of Medicine, Japan.
D004273:DNA, Neoplasm / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000032:analysis / Q000401:mortality / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate
D004273:DNA, Neoplasm