Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of gentamicin.
Administration of the aminoglycoside antibiotic, gentamicin, even at therapeutic doses, causes renal lysosomal phospholipidosis. We now report that protein- and lipid-bound sialic acid levels are increased significantly in a time-dependent fashion in the renal cortex of rats injected with gentamicin (10 mg/kg body wt. per day) for 4-10 days and a significant relationship could be observed between these two parameters. This elevation was not due to tissue regeneration, since it was not observed in cisplatin-treated animals.
Kishore
B K
BK
Laboratoire de Chimie Physiologique, Université Catholique de Louvain, Brussels, Belgium.
Ibrahim
S
S
Tulkens
P M
PM
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism; D019158:N-Acetylneuraminic Acid; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000378:metabolism*
D005839:Gentamicins; D010743:Phospholipids; D012794:Sialic Acids; D010758:Phosphorus; D019158:N-Acetylneuraminic Acid; D002945:Cisplatin