title: A theoretical description of arterial pressure-flow relationships with verification in the isolated hindlimb of the dog.
abstract: We developed and tested a new two-compartment serial model of the arterial vasculature which unifies the capacitance (downstream arterial compliance) and waterfall (constant downstream pressure load) theories of blood flow through the arteries. In this model, blood drains from an upstream compliance through a resistance into a downstream compliance which empties into the veins through a downstream resistance which terminates in a constant pressure load. Using transient arterial pressure data obtained from an isolated canine hindlimb preparation, we tested this model, using a stop-flow technique. Numerical parameter estimation techniques were used to estimate the physiologic parameters of the model. The downstream compliance was found to be more than ten times larger than the upstream compliance and the constant pressure load was significantly above venous pressures but decreased in response to vasodilation. Our results support the applicability of both the capacitance and waterfall theories.
authors.affiliation: Department of Chemical Engineering, University of California, Davis 95616.
authors.forename: A P
authors.initials: AP
authors.lastname: Jackman
authors.forename: J F
authors.initials: JF
authors.lastname: Green
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology*; D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001810:Blood Volume; D004285:Dogs; D005263:Femoral Artery / Q000502:physiology; D006614:Hindlimb / Q000098:blood supply; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014690:Venous Pressure / Q000502:physiology