title: Pulmonary carcinogenesis in rats given implants of shale oil in beeswax pellets.
abstract: Pellets of crude shale oil, neutral, basic, or polynuclear aromatic fractions of shale oil, or crude petroleum were implanted in the lungs of rats through a thoracotomy. The pellets had a beeswax-tricaprylin vehicle that allowed the slow release of material into the surrounding parenchyma. A dose-related incidence of lung cancer was observed with each of the materials studies. A greater risk for lung cancer was not demonstrated for crude shale oil compared to crude petroleum.
authors.affiliation: Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, Washington 99352.
authors.forename: G E
authors.initials: GE
authors.lastname: Dagle
authors.forename: L G
authors.initials: LG
authors.lastname: Smith
authors.forename: K E
authors.initials: KE
authors.lastname: McDonald
authors.forename: J F
authors.initials: JF
authors.lastname: McShane
authors.forename: D L
authors.initials: DL
authors.lastname: Stevens
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004343:Drug Implants; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D010578:Petroleum / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004343:Drug Implants; D010578:Petroleum