title: Stress increases noradrenaline release in the rat frontal cortex: prevention by diazepam.
abstract: Foot-shock produced a more than 2-fold increase in noradrenaline (NA) release from the frontal cortex of freely moving rats. The effect of acute stress was almost completely prevented by the administration of diazepam (5 mg/kg i.p.). Diazepam alone inhibited cortical NA release, the maximal inhibition (-57%) being observed 90 min after the injection. Cortical NA release therefore appears to be a reliable index of central noradrenergic activity in response to stressful conditions.
authors.affiliation: 'B.B. Brodie' Department of Neuroscience, University of Cagliari, Italy.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Rossetti
authors.forename: C
authors.initials: C
authors.lastname: Portas
authors.forename: L
authors.initials: L
authors.lastname: Pani
authors.forename: S
authors.initials: S
authors.lastname: Carboni
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D003975:Diazepam / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D003975:Diazepam; D009638:Norepinephrine