title: [Characteristics of the long-term effects of niphtholide on the functional state of the testes in animals].
abstract: Long-term application of non-steroid antiandrogen niphtholid (10 or 25 mg/kg daily for 8-9 months) exerts a stimulating effect on the functional state of testicles. This effect is more pronounced in rats, than in dogs and guinea pigs. In all these animals the drug antiandrogenic effect caused a decrease of the prostatic mass, while in rats--an increase of the adenohypophysis mass. The peculiarities of the niphtholid effect in various animals should be taken into account when evaluating and interpreting investigation results.
authors.forename: S V
authors.initials: SV
authors.lastname: Varga
authors.forename: L V
authors.initials: LV
authors.lastname: Chaĭkovskaia
mesh_terms: D000813:Anilides / Q000008:administration & dosage*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005485:Flutamide / Q000008:administration & dosage* / Q000494:pharmacology; D006168:Guinea Pigs; D008297:Male; D051381:Rats; D013045:Species Specificity; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000813:Anilides; D013739:Testosterone; D005485:Flutamide
vernacular_title: Osobennosti prodolzhitel'nogo vozdeĭstviia niftolidom na funktsional'noe sostoianie semennikov zhivotnykh.