Metabolism and nephrotoxicity of indan in male Fischer 344 rats.
Indan, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-indanol, 2-indanol, 5-indanol, 1-indanone, 2-indanone, 2-hydroxy-1-indanone, cis-1,2-indandiol, and trans-1,2-indandiol. The metabolites were identified using the techniques of gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The rats treated with indan demonstrated the classic lesions of hydrocarbon-induced nephropathy. The kidney damage produced was less than that found for tetralin and other branched-chain acyclic hydrocarbons.
Servé
M P
MP
Department of Chemistry, Wright State University, Dayton, Ohio 45435.
Ferry
M J
MJ
Yu
K O
KO
Olson
C T
CT
Hobson
D W
DW
D000284:Administration, Oral; D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D007189:Indans / Q000378:metabolism / Q000633:toxicity* / Q000652:urine; D007192:Indenes / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D007189:Indans; D007192:Indenes