[Experimental study of liver allograft damage during cold ischemia].
Changes on the majority of structural complexes were observed in livers that underwent the influence of the preservant and cold ischemia. Cellular architecture of a such liver is disturbed. Hepatocites are with granular and vacuolar degeneration: focal cariolyzes and piasmolyzes are present, partial destruction of cellular membrane is noticeable. The dilatation of sinusoidal spaces is very emphasized and followed by the severe loss of endothelium. These changes along with the disturbed cellular architecture represent the findings of Pelosis hepatis. It is important to emphasize the significance of changes observed on liver sinusoids and endothelium especially since their intensity is much greater than of those changes observed on parenchim. We assume that these angioarchitectural damages play an important role in the onset and development of cardiopulmonal and coagulopatic components of the postreperfusional syndrome. The fact that the postreperfusional syndrome was also observed in cases with heterotopic transplantation could support this assumption.
Tasić
M
M
Fabri
M
M
Vuković
R
R
D000818:Animals; D003080:Cold Temperature; D004285:Dogs; D008099:Liver / Q000473:pathology*; D016031:Liver Transplantation; D009926:Organ Preservation / Q000009:adverse effects*
Eksperimentalna istrazivanja ostećenja alografta jetre u toku hladne ishemije.