Multiple molecular forms of rat liver glucose-6-phosphate dehydrogenase during liver hyperplasia induced by lead nitrate.
In the present study the three dimeric molecular forms of rat liver glucose-6-phosphate dehydrogenase were investigated during liver hyperplasia induced by lead nitrate. An increase of band 3 and a concomitant decrease of band 1 was found, indicating that this proliferating process is characterized by a peculiar pattern in the distribution of liver G6PD activity. Since the same pattern was observed also in liver hyperplasia induced in fasted animals, a condition otherwise characterized by a shift towards band 1, we suggest that during proliferating processes the metabolic control normally exerted by fasting on the enzymatic activity is overcome.
Batetta
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Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Italy.
Dessì
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Pulisci
D
D
Carrucciu
A
A
Pani
P
P
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005215:Fasting / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006965:Hyperplasia / Q000139:chemically induced; D007527:Isoenzymes / Q000378:metabolism*; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000473:pathology*; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D007527:Isoenzymes; D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D005954:Glucosephosphate Dehydrogenase