Complex translocations in a patient with chronic myelocytic leukemia: t(9;22;17) and t(10;18;19) after two failed bone marrow transplantations.
A 6-year-old white boy with chronic myelogenous leukemia (CML) (adult type) developed complex translocations after a bone marrow transplant (BMT): t(9;22;17)(q34;q11;p12) t(10;18;19)(p11;q11;p12) and in the accelerated phase. The patient relapsed after his BMT and underwent a second BMT after a documented blast crisis. The previous karyotypic translocations persisted.
Melnyk
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Loyola University Medical Center, Maywood, Illinois.
Kowal-Vern
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D016026:Bone Marrow Transplantation; D002648:Child; D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000601:surgery; D008297:Male; D014178:Translocation, Genetic