Ultrastructural observations of non-selective effects of ricin treatment (RCA-120) in the rat dorsal root ganglion.
The effects of ricin (RCA-120) on non-injected dorsal root ganglion (DRG) cells, sharing the same DRG as the injected ones, were studied after ricin injections into the tibial nerve and B-HRP injections into the peroneal nerve. Numerous DRG cells containing B-HRP reaction product and exhibiting signs of advanced degeneration were observed. The findings suggest that ricin may be released from dying injected DRG neurons and taken up by adjacent non-injected DRG cells, which subsequently degenerate.
Rivero-Melián
C
C
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Arvidsson
J
J
D000818:Animals; D002772:Cholera Toxin; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D006735:Horseradish Peroxidase; D037102:Lectins / Q000493:pharmacokinetics / Q000494:pharmacology*; D009410:Nerve Degeneration / Q000187:drug effects*; D037121:Plant Lectins; D051381:Rats; D011919:Rats, Inbred Strains
D037102:Lectins; D037121:Plant Lectins; C017707:Ricinus communis agglutinin-1; C052635:cholera toxin, B subunit-horseradish peroxidase; D002772:Cholera Toxin; D006735:Horseradish Peroxidase