Arterial baroreceptor reflex modulation of sympathetic-cardiovascular adjustments to heat stress.
The purpose of this study was to determine if the arterial baroreceptor reflexes modulate the sympathocirculatory responses to acute heat stress. To address this, arterial pressure, heart rate, mesenteric and renal blood flow velocity (Doppler flow probes), arterial plasma norepinephrine, and colonic temperature were measured before and during whole body heating (42 degrees C ambient temperature) in groups of conscious, unrestrained rats with (sham) or without (sinoaortic deafferentation) intact arterial baroreceptor reflexes. Heating was stopped when a colonic temperature of 41 degrees C was attained. Baseline levels of arterial pressure were similar in the two groups, whereas heart rate was elevated in deafferented versus sham-operated rats (p less than 0.01). The increases above baseline for both arterial pressure (73 +/- 4 vs. 27 +/- 2 mm Hg) and heart rate (127 +/- 10 vs. 33 +/- 5 beats/min) were threefold to fourfold greater at the end of heating in the deafferented versus the sham group (p less than 0.01). Declines in mesenteric and renal blood flow were similar in the two groups during heating; however, deafferented rats had greater increases in both mesenteric and renal vascular resistance (p less than 0.05). Plasma norepinephrine was elevated at baseline in deafferented versus sham rats and increased in both groups during heating (p less than 0.01). The magnitude of the increase in plasma norepinephrine from baseline to 41 degrees C was fivefold greater in the deafferented versus the sham rats (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Kregel
K C
KC
Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721.
Johnson
D G
DG
Tipton
C M
CM
Seals
D R
DR
D000818:Animals; D001158:Arteries / Q000294:innervation / Q000503:physiopathology*; D001831:Body Temperature; D002319:Cardiovascular System / Q000503:physiopathology*; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011311:Pressoreceptors / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D009638:Norepinephrine