Ly-1 B cells and disease activity in (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation.
The treatment of female (New Zealand black x New Zealand white)F1 mice with total lymphoid irradiation resulted in a prolonged remission of autoimmune disease activity. Total lymphoid irradiation-treated mice also showed a marked reduction of Ly-1 B cells, which lasted up to 3 months. The subsequent return of Ly-1 B cells to preirradiation levels was not associated with a simultaneous return of disease when measured by parameters such as IgG anti-DNA antibodies and spontaneous secretion of IgG by splenic cells. In cell sorting experiments, most of the cells spontaneously secreting IgG were found within the Ly-1- (CD5-) splenic B cell population.
Fariñas
M C
MC
Department of Medicine, Stanford University School of Medicine, California 94305.
Stall
A M
AM
Solovera
J J
JJ
Tarlinton
D M
DM
Herzenberg
L A
LA
Strober
S
S
D000818:Animals; D000950:Antigens, Ly / Q000032:analysis*; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects; D002469:Cell Separation; D004247:DNA / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D015182:Lymphatic Irradiation; D051379:Mice; D008814:Mice, Inbred NZB; D010529:Peritoneal Cavity / Q000166:cytology; D013154:Spleen / Q000276:immunology / Q000473:pathology
D000950:Antigens, Ly; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA