title: Influence of retinoids on bladder cancer growth as detected by primary tissue culture.
abstract: The ability of the retinoid compounds, all-trans and 13-cis, to inhibit the growth of bladder tumour cells was investigated in primary tissue culture. A significant decrease in tumour growth was evident in 9 human bladder cancer patients. Since retinoid compounds are able to delay the progression or induction of tumours in primary tissue culture, their trial use as intravesical agents may be warranted.
authors.affiliation: Department of Urology, College of Physicians, Columbia University, New York.
authors.forename: I S
authors.initials: IS
authors.lastname: Sawczuk
authors.forename: C A
authors.initials: CA
authors.lastname: Olsson
authors.forename: J R
authors.initials: JR
authors.lastname: Mertz
mesh_terms: D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007536:Isomerism; D014212:Tretinoin / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D014212:Tretinoin