title: Effect of vestibulo-cerebellar lesions on asymmetry of vertical optokinetic functions in the squirrel monkey.
abstract: The role of the cerebellar uvula and nodulus in vertical optokinetic after-nystagmus (OKAN) was studied in 4 squirrel monkeys. Aspiration ablation of the uvula and nodulus resulted in no significant change in the initial or peak gain of vertical optokinetic nystagmus (OKN) during the 24-week post-operative observation. However, the asymmetry of vertical OKAN was significantly altered. Using a protracted upward OK stimulus, slow phase-down OKAN-II, which was not seen pre-operatively, was significantly increased. In contrast, a downward OK stimulus produced little change in slow phase-up OKAN-II. Thus, the asymmetric degree of vertical OKAN-II was decreased after uvulonodulectomy. In addition, there was a post-operative reduction in the vertical oculomotor stability. When slow-phase eye velocity of OKAN was plotted along the time scale, the amplitude and frequency of the sinusoidal pattern was increased. OKAN-III and OKAN-IV were found in 50% of the monkeys after uvulonodulectomy. It is therefore thought that inhibition and directional control from the uvula and nodulus influence the stability and asymmetrical behaviour of the leaky integrator in the second order output system.
authors.affiliation: Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: T
authors.initials: T
authors.lastname: Himi
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: N
authors.initials: N
authors.lastname: Takeda
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D005133:Eye Movements / Q000502:physiology*; D009760:Nystagmus, Physiologic / Q000502:physiology*; D012453:Saimiri; D014722:Vestibule, Labyrinth / Q000502:physiology*