title: The neuropathic oesophagus. A radiographic and manometric study on the evolution of megaoesophagus in dogs with developing axonal neuropathy.
abstract: Dogs given the neurotoxin acrylamide develop peripheral neuropathy and megaoesophagus. Sequential radiographic and manometric studies on the oesophagus demonstrated that the initial abnormalities consisted of a progressive decrease in the proportion of swallows that initiated peristalsis and a gradual increase in oesophageal calibre. Regurgitation, peristaltic failure and oesophageal dilatation all appeared within three days. The eating behaviour and gait abnormalities quickly resolved on stopping the neurotoxin, but the oesophagus remained dilated for longer. Previous studies have suggested that the abnormalities present in dogs which are developing a distal axonal neuropathy or in some dogs with idiopathic megaoesophagus may be limited to the proprioceptive elements of the oesophageal innervation. The present study suggests that the progressive inefficiency in the transmission of swallows and changes in oesophageal calibre in dogs with evolving megaoesophagus may be a consequence of damage to these proprioceptive elements.
authors.affiliation: Gordon Craig Laboratory, Department of Surgery, University of Sydney, Australia.
authors.forename: P M
authors.initials: PM
authors.lastname: Satchell
mesh_terms: D020106:Acrylamide; D000178:Acrylamides; D000818:Animals; D001369:Axons / Q000473:pathology*; D003679:Deglutition; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D004285:Dogs; D004931:Esophageal Achalasia / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology; D008365:Manometry / Q000662:veterinary; D010528:Peristalsis; D011312:Pressure; D011859:Radiography
chemical_list: D000178:Acrylamides; D020106:Acrylamide