title: Cholestyramine resin ameliorates chronic aminonucleoside nephrosis.
abstract: We chose to assess the role of cholesterol reduction in chronic aminonucleoside nephrosis by pharmacologically lowering serum cholesterol with cholestyramine. Two groups of rats were made nephrotic with a single intravenous dose of puromycin aminonucleoside (PA): one group (PA/resin) received 5% (w:w in diet) cholestyramine resin and the dietary control group (PA/cell) received 5% cellulose. Cholestyramine-treated rats demonstrated significant functional and histological protection. Recurrent proteinuria was significantly lower in PA/resin animals. Whole-kidney glomerular filtration rate in the PA/resin group was preserved at a level equivalent to normal age-matched control rats whereas the PA/cell group had a significantly lower value than did the normal animals. The extent of segmental glomerulosclerosis 24 wk after PA delivery was significantly lower in the PA/resin group. These results suggest a role for hyperlipidemia as one of the mechanisms involved in the pathogenesis of progressive glomerular disease.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston.
authors.forename: J R
authors.initials: JR
authors.lastname: Diamond
authors.forename: N A
authors.initials: NA
authors.lastname: Hanchak
authors.forename: M D
authors.initials: MD
authors.lastname: McCarter
authors.forename: M J
authors.initials: MJ
authors.lastname: Karnovsky
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006937:Hypercholesterolemia / Q000517:prevention & control*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D011692:Puromycin Aminonucleoside; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002792:Cholestyramine Resin; D011692:Puromycin Aminonucleoside; D002784:Cholesterol