Pulmonary carcinoid presenting as multiple subcutaneous nodules.
A 60-year-old female presented with a one-year history of multiple enlarging tender subcutaneous nodules. Initial biopsy demonstrated a poorly differentiated adenocarcinoma. Mammography showed multiple nodular breast lesions. After the patient failed to respond to tamoxifen, a second biopsy demonstrated a metastatic carcinoid tumor. Further search revealed a single small pulmonary nodule, which on aspiration biopsy proved to be a carcinoid tumor. The patient failed to respond to treatment with streptozotocin and 5'-fluorouracil. Therapy with leucovorin calcium and 5'-fluorouracil then produced a partial response.
Oleksowicz
L
L
Mount Sinai School of Medicine, Department of Neoplastic Diseases, New York, N.Y. 10029.
Morris
J C
JC
Phelps
R G
RG
Bruckner
H W
HW
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*
D002955:Leucovorin; D005472:Fluorouracil