title: Percutaneous absorption of zinc from zinc oxide applied topically to intact skin in man.
abstract: The penetration of zinc through normal skin treated with a zinc oxide (25%) medicated occlusive dressing was studied. The mean release rate of zinc to the skin was 5 micrograms/cm2/h. After 48 h of treatment suction blisters were raised by the "Kiistala method." The zinc concentration of the epidermis, blister fluid and dermis was increased beneath the zinc dressing compared to control-treated skin. The study shows that zinc permeates intact human skin from topically applied zinc oxide in vivo.
authors.affiliation: Department of Pathology, Faculty of Health Sciences, Linkoping, Sweden.
authors.forename: M S
authors.initials: MS
authors.lastname: Agren
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001768:Blister / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D012869:Skin Absorption / Q000187:drug effects*; D015032:Zinc / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D015032:Zinc; D015034:Zinc Oxide