title: A linkage study of malignant hyperthermia (MH).
abstract: Five German families segregating for malignant hyperthermia (MH) were tested for linkage relationships using 35 serological and biochemical markers. Slightly positive lod scores were obtained with MNS, EsD, C3 and P. The relation with the C3 locus on chromosome 19p13.3-13.2 (z = 0.72, theta = 0.11) is of some interest, since genetic linkage of MH with several polymorphic DNA markers from the 19q12-13.2 region has been reported (McCarthy et al. 1989).
authors.affiliation: Institut für Humangenetik und Anthropologie, Universität Freiburg, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Bender
authors.forename: H
authors.initials: H
authors.lastname: Senff
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: C
authors.initials: C
authors.lastname: Spiess-Kiefer
authors.forename: F
authors.initials: F
authors.lastname: Lehmann-Horn
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008305:Malignant Hyperthermia / Q000097:blood / Q000235:genetics*
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers