title: A quantitative structure-activity relationship study for local anesthetic activity of mono-and diaryl-2-quinuclidinylcarbinols.
abstract: The local anesthetic activity of a series of arylquinuclidinylcarbinols is shown to be significantly correlated with their lipophilic character, suggesting that lipophilicity is an important factor for the local anesthetic action of drugs.
authors.affiliation: Birla Institute of Technology and Science, Pilani, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Gupta
authors.forename: R N
authors.initials: RN
authors.lastname: Saha
authors.forename: J K
authors.initials: JK
authors.lastname: Gupta
mesh_terms: D000438:Alcohols; D000779:Anesthetics, Local; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011812:Quinuclidines; D013329:Structure-Activity Relationship
chemical_list: D000438:Alcohols; D000779:Anesthetics, Local; D011812:Quinuclidines