Liver glutathione contents in patients with gastric adenocarcinomas.
Many antineoplastic agents alter the reduced glutathione (GSH) status of liver and tumor tissue by inhibiting cellular GSH-linked enzymes. Thus, intracellular GSH plays an important role in a wide variety of antineoplastic interventions regarding therapeutic efficacy and toxicity. Mean GSH values were 0.791 +/- 0.072 mg/m wet weight (ww) and 0.719 +/- 0.047 mg/g ww in gastric cancer tissue and nontumorous glandular mucosa, respectively. Whereas, the average GSH level of normal gastric mucosa was 1.709 +/- 0.135 mg/g, the mean GSH level of normal liver biopsies was 2.378 +/- 0.260 mg/g. The GSH values of normal liver tissue were higher than the hepatocellular GSH concentrations of patients with gastric adenocarcinoma and of another group of tumor-bearing patients who had received chemotherapy preoperatively. These results suggest that the GSH levels of tumor and liver may influence the efficacy and/or toxicity of chemotherapeutic agents.
Engin
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A
Department of Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ferahköse
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Z
D000230:Adenocarcinoma / Q000032:analysis* / Q000188:drug therapy; D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000032:analysis* / Q000188:drug therapy
D005978:Glutathione