[Several years observation of a Catergen (cyanidanol-3) induced immunohemolysis].
A report is presented on repeated severe episodes of cyanidanol-induced immune hemolysis in a 75-year-old woman suffering from chronic active hepatitis. One year after the first hemolytic episode, high titers of anticyanidanol antibodies were still demonstrated in the patient's serum (as well as sensitization of the patient's lymphocytes by the drug). 4 years later virtually no decrease of the antibody titer was found. Further investigations of the patient's serum revealed antibodies against flavonoids with free hydroxyl groups (cyanidanol and rutin). However, no antibodies against flavonoids with derivatized hydroxyl groups (troxerutin, mixture of hydroxy-ethyl-rutin and silibinin) could be demonstrated. Sensitization with flavonoids other than cyanidanol preceding cyanidanol-induced hemolysis has been proposed by others. In this case storage of approximately 75 flavonoid containing preparations in a chemist's shop in the patient's house may have contributed to the astonishing persistence of dry dependent antibodies.
Stühlinger
W
W
Abteilung für Innere Medizin, Krankenhaus Kufstein, Osterreich.
Berek
K
K
Grösswang
F
F
Schauer
N
N
D000368:Aged; D002392:Catechin / Q000009:adverse effects* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000276:immunology; D006461:Hemolysis / Q000187:drug effects* / Q000276:immunology; D006521:Hepatitis, Chronic / Q000188:drug therapy; D006801:Humans; D007159:Immunologic Tests; D008213:Lymphocyte Activation; D011852:Radioallergosorbent Test
D002392:Catechin
Mehrjährige Verlaufsbeobachtung einer durch Catergen (Cyanidanol-3) induzierten Immunhämolyse.