title: Mitotic disturbance associated with mosaic aneuploidies.
abstract: The association of various unsystematic aneuploidies with premature centromere division (PCD) was observed in a patient with conspicuous clinical features and combined immunodeficiency. Trisomies and monosomies of almost all autosomes and gonosomal aberrations were found separately or in combination in a majority of the proband's lymphocytes and fibroblasts. The chromosome number varied from 44 to 50. A high proportion of the metaphases showed PCD or had the appearance of C-anaphases. These findings probably represent a new mutant affecting mitosis and causing mosaic aneuploidies.
authors.affiliation: Abteilung Humangenetik, Medizinische Hochschule, Hannover, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: W
authors.initials: W
authors.lastname: Müller
authors.forename: L
authors.initials: L
authors.lastname: Winkler
authors.forename: M R
authors.initials: MR
authors.lastname: Hadam
authors.forename: J H
authors.initials: JH
authors.lastname: Ehrich
authors.forename: S D
authors.initials: SD
authors.lastname: Flatz
mesh_terms: D000782:Aneuploidy; D002503:Centromere / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008297:Male; D008938:Mitosis; D009030:Mosaicism; D009630:Nondisjunction, Genetic