Naltrexone for treatment of acral lick dermatitis in dogs.
Acral lick dermatitis (lick granuloma) was diagnosed in 11 dogs on the basis of history, physical examination, and histopathologic findings. A predilection for the left forelimb was noticed. All 11 dogs were given the narcotic antagonist naltrexone. Successful treatment (cessation of licking, reepithelialization of lesions) was seen in 7 dogs. All 7 dogs' lesions recurred when naltrexone was stopped, but reepithelialized in 5 dogs when the drug was readministered. Adverse effects (drowsiness, withdrawal from owner) were seen in 1 dog, but resolved within 48 hours of stopping the drug.
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Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80526.
D000818:Animals; D003872:Dermatitis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004341:Drug Evaluation / Q000662:veterinary; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D010241:Parakeratosis / Q000188:drug therapy / Q000662:veterinary; D012008:Recurrence
D009271:Naltrexone; D004917:Erythromycin