title: [The course of illness in ulcerative colitis].
abstract: The data of 301 ulcerative proctitis/colitis patients, with a mean follow-up of 10 (1/2-26) years were analysed retrospectively. In 84 patients (28%) the diagnosis was made in this hospital (non-selected group), the other 217 patients were referred from other hospitals with an established diagnosis of ulcerative colitis. At any time after the fifth year of illness approximately 55% of the non-selected patients were free of symptoms, for the referred patients this proportion was 30%. In one half of the cases the inflammation started as a proctitis, almost 60% of these progressed to colitis later. Fourteen patients (5%) had a toxic megacolon, and a colon carcinoma developed in 9 patients (3%) on average 13 years after the first symptoms of colitis. We recorded 9 colitis-related deaths. Fifty patients (17%) underwent a colectomy, mostly because of failure of conservative therapy.
authors.affiliation: Sint-Radboudziekenhuis, Kliniek voor Inwendige Ziekten, afd. Maag-Darm-en Leverziekten, Nijmegen.
authors.forename: R M
authors.initials: RM
authors.lastname: Perenboom
authors.forename: M C
authors.initials: MC
authors.lastname: Rijk
authors.forename: G H
authors.initials: GH
authors.lastname: Rikken
authors.forename: J H
authors.initials: JH
authors.lastname: van Tongeren
mesh_terms: D003093:Colitis, Ulcerative / Q000150:complications* / Q000401:mortality / Q000628:therapy; D003110:Colonic Neoplasms / Q000150:complications; D003131:Combined Modality Therapy; D005260:Female; D008297:Male; D008532:Megacolon, Toxic / Q000150:complications; D011349:Proctitis / Q000150:complications*; D012189:Retrospective Studies
vernacular_title: Het ziektebeloop bij colitis ulcerosa.