title: Efficacies of erythromycin and chloramphenicol in extinguishing fecal shedding of Campylobacter jejuni in dogs.
abstract: Oral treatment regimens of erythromycin stearate and chloramphenicol were evaluated in naturally infected laboratory colony dogs for their efficacies in extinguishing fecal shedding of Campylobacter jejuni. Of the 25 Campylobacter-infected English Foxhounds in the study, 9 were assigned to erythromycin treatment, 9 to chloramphenicol treatment, and 7 to no treatment. Antimicrobials were administered for 12 days. All of the dogs that received erythromycin stearate ceased shedding C jejuni by the fourth day of treatment and remained negative throughout the treatment period. Chloramphenicol was associated with a reduction in shedding from 100% to 57% by the ninth day of treatment. Within 9 days of the discontinuation of antimicrobial treatment, C jejuni was isolated from all chloramphenicol-treated dogs and 89% erythromycin-treated dogs.
authors.affiliation: Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Ohio State University, Columbus 43210.
authors.forename: J D
authors.initials: JD
authors.lastname: Monfort
authors.forename: J P
authors.initials: JP
authors.lastname: Donahoe
authors.forename: H F
authors.initials: HF
authors.lastname: Stills
authors.forename: S
authors.initials: S
authors.lastname: Bech-Nielsen
mesh_terms: D000818:Animals; D002169:Campylobacter Infections / Q000188:drug therapy / Q000662:veterinary*; D002168:Campylobacter fetus / Q000187:drug effects / Q000254:growth & development; D002701:Chloramphenicol / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004341:Drug Evaluation / Q000662:veterinary; D004917:Erythromycin / Q000627:therapeutic use*; D005243:Feces / Q000382:microbiology*; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D013997:Time Factors
chemical_list: D004917:Erythromycin; D002701:Chloramphenicol