Effect of novidium (homidium chloride) chemotherapy on genital lesions induced by Trypanosoma vivax and Trypanosoma congolense infections in Zebu bulls.
Zebu bulls chronically infected with Trypanosoma vivax and T. congolense were treated at the 12th week post-infection with novidium and slaughtered at different times after treatment to determine histological evidence of healing of the genital lesions. Though trypanosomes disappeared from the blood soon after chemotherapy, there was incomplete resolution of genital lesions even 10-18 weeks later. Where there is severe degeneration of the testes and epididymes chemotherapy may be ineffective in leading to regeneration and therefore infertility problems may persist in bulls with chronic trypanosomiasis which are later subjected to chemotherapy.
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National Animal Production Research Institute, Ahmadu Bello University, Shika, Zaria, Nigeria.
D000818:Animals; D002417:Cattle; D004996:Ethidium / Q000627:therapeutic use*; D005837:Genitalia, Male / Q000473:pathology*; D008297:Male; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000662:veterinary; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy*
D014344:Trypanocidal Agents; D004996:Ethidium