title: No rarefaction of cerebral arterioles in hypertensive rats.
abstract: A reduction in the density of small arterioles (rarefaction) has been reported in several vascular beds of the spontaneously hypertensive rat (SHR). There have been conflicting reports on the existence of rarefaction in the pial vasculature of SHR. In this study, we determined whether there was rarefaction of pial arterioles in several models of hypertension. We studied SHR; two-kidney, one-clip Goldblatt hypertensive rats; deoxycorticosterone-salt hypertensive rats; and Dahl salt-sensitive rats fed high salt diet. The two groups of normotensive controls were Wistar--Kyoto rats and Dahl salt-sensitive rats fed low salt diet. The duration of hypertension was about 2 months. Density of first-, second-, third-, and fourth-order arterioles was determined by counting the number of vessels from enlarge photographs. We also measured the lengths of segments of the arterioles. We did not observe any evidence of rarefaction of arterioles in the pial vasculature in any of the hypertensive groups of rats. We conclude that (i) rarefaction of arterioles does not occur in the pial microvasculature after approximately 2 months of hypertension and (ii) rarefaction of pial arterioles does not account for abnormalities in the cerebral circulation of hypertensive rats such as protection of the blood-brain barrier or changes in autoregulation of cerebral blood flow.
authors.affiliation: Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
authors.forename: A H
authors.initials: AH
authors.lastname: Werber
authors.forename: M C
authors.initials: MC
authors.lastname: Fitch-Burke
authors.forename: D G
authors.initials: DG
authors.lastname: Harrington
authors.forename: J
authors.initials: J
authors.lastname: Shah
mesh_terms: D000818:Animals; D001160:Arterioles / Q000503:physiopathology; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000473:pathology / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D003900:Desoxycorticosterone