Stress increases noradrenaline release in the rat frontal cortex: prevention by diazepam.
Foot-shock produced a more than 2-fold increase in noradrenaline (NA) release from the frontal cortex of freely moving rats. The effect of acute stress was almost completely prevented by the administration of diazepam (5 mg/kg i.p.). Diazepam alone inhibited cortical NA release, the maximal inhibition (-57%) being observed 90 min after the injection. Cortical NA release therefore appears to be a reliable index of central noradrenergic activity in response to stressful conditions.
Rossetti
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ZL
'B.B. Brodie' Department of Neuroscience, University of Cagliari, Italy.
Portas
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C
Pani
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Carboni
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Gessa
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GL
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis; D003975:Diazepam / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000378:metabolism*
D003975:Diazepam; D009638:Norepinephrine