Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat.
BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria (greater than 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in both combinations of crosses.
Matsuyama
M
M
Second Department of Pathology, Nagoya University Medical School, Japan.
Ogiu
T
T
Kontani
K
K
Yamada
C
C
Kawai
M
M
Hiai
H
H
Nakamura
T
T
Shimizu
F
F
Toyokawa
T
T
Kinoshita
Y
Y
D000419:Albuminuria / Q000652:urine; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005808:Genes, Recessive; D005921:Glomerulonephritis / Q000235:genetics*; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains