title: Evidence for a pathogenic role of omega 6 polyunsaturated fatty acid in the cutaneous manifestations of biotin deficiency.
abstract: Abnormalities in fatty acid composition have been detected in biotin deficiency in humans and in the rat. However, the pathogenetic role of these abnormalities, if any, in the cutaneous manifestations of biotin deficiency is not clear. In a nutrient interaction experiment, we tested the hypothesis that an abnormality of omega 6 polyunsaturated fatty acid (PUFA) metabolism plays a pathogenetic role in the cutaneous manifestations. Five rats were fed an egg white diet that induces biotin deficiency; these rats developed the characteristic cutaneous abnormalities of biotin deficiency. Five additional rats were pair-fed the egg white diet and received Liposyn [77% linoleic acid (18:2 omega 6)]; these rats did not develop the cutaneous manifestations of biotin deficiency. The two groups had similar decreases in the rates of urinary excretion of biotin, the serum concentrations of biotin, the amounts of biotin in liver, and the hepatic activities of two biotin-dependent carboxylases; the two groups had similar increases in the rates of urinary excretion of 3-hydroxyisovaleric acid. These observations provide evidence that (a) some abnormality in omega 6 PUFA metabolism has a pathogenetic role in the cutaneous manifestations of biotin deficiency and (b) this pathogenetic role can not be explained as a difference in biotin nutritional status due to a biotin-sparing effect of Liposyn.
authors.affiliation: Department of Pediatrics, University of Iowa, Iowa City 52242.
authors.forename: D M
authors.initials: DM
authors.lastname: Mock
mesh_terms: D000818:Animals; D001710:Biotin / Q000097:blood / Q000172:deficiency* / Q000652:urine; D001835:Body Weight; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008297:Male; D009752:Nutritional Status; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000209:etiology* / Q000378:metabolism
chemical_list: D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D001710:Biotin