[In vitro chemosensitivity test: succinate dehydrogenase inhibition (SDI) test].
The succinate dehydrogenase inhibition (SDI) test was used for determining chemosensitivity of various human tumors. This test was based on the correlation between the cellular succinate dehydrogenase activity as determined by 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT), and cell viability. The chemosensitivity varied in the tissue. Some factors are involved in the chemosensitivity, that is origin of a tumor, tissue differentiation and tissue DNA synthetic activity. This test is a convenient method for clinical use and provides important information about chemosensitivity.
Maehara
Y
Y
2nd Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka.
Kohnoe
S
S
Emi
Y
Y
Sakaguchi
Y
Y
Sugimachi
K
K
D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013274:Stomach Neoplasms / Q000473:pathology; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*
D013385:Succinate Dehydrogenase