title: Bilateral choroidal neonatal neuroblastoma.
abstract: We treated a bilateral, well-differentiated neuroblastoma of the choroid in a patient who had congenital abdominal neuroblastoma. Although orbital metastasis of neuroblastoma is common, intraocular metastasis is not. In our patient, there was no amplification of the N-myc oncogene in the tumor of either eye. This is consistent with early-stage primary neuroblastoma. Histologically, the tumors were identical in each eye and well differentiated with Homer Wright rosettes; most neuroblastoma metastases have few rosettes and are composed of more undifferentiated, anaplastic cells. We believe that our patient had bilateral primary tumors and not metastatic tumors.
authors.affiliation: Children's Mercy Hospital, Section of Ophthalmology, Kansas City, Missouri.
authors.forename: G W
authors.initials: GW
authors.lastname: Cibis
authors.forename: A I
authors.initials: AI
authors.lastname: Freeman
authors.forename: V
authors.initials: V
authors.lastname: Pang
authors.forename: G J
authors.initials: GJ
authors.lastname: Roloson
authors.forename: W F
authors.initials: WF
authors.lastname: Case
authors.forename: M
authors.initials: M
authors.lastname: Ost
authors.forename: M
authors.initials: M
authors.lastname: Huntrakoon
authors.forename: P G
authors.initials: PG
authors.lastname: Rothberg
mesh_terms: D002830:Choroid Neoplasms / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000151:congenital*; D009447:Neuroblastoma / Q000151:congenital* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed