title: Relationship between the hydrophobic and hydrophilic molecular parameters of some synthetic nucleosides, determined by means of adsorptive and reversed-phase thin-layer chromatography.
abstract: The adsorption capacity, the specific adsorptive surface, the lipophilicity and the specific hydrophobic surface of 59 natural and synthetic nucleoside derivatives were determined by means of adsorptive chromatography and reversed-phase thin-layer chromatography for the future application of these molecular parameters in quantitative structure-activity relationship studies. Stepwise regression analysis and principal component analysis proved that each of the physico-chemical parameters has a different information content, and their application in the design of new bioactive derivatives is therefore justified.
authors.affiliation: Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
authors.forename: T
authors.initials: T
authors.lastname: Cserháti
authors.forename: K
authors.initials: K
authors.lastname: Valko
mesh_terms: D000327:Adsorption; D002855:Chromatography, Thin Layer / Q000379:methods; D009705:Nucleosides; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D009705:Nucleosides; D014867:Water