In vivo effect of the tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro, on the G1-S transition of rat hepatocytes.
The synthetic molecule N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), corresponding to the low molecular weight inhibitory factor preventing in vivo haematopoietic stem cell (CFU-S) entry into DNA synthesis, was tested in two heterologous systems in vivo: adult regenerating rat liver and 10-day-old rat hepatocytes synchronized by an irritating trigger. In both systems, it was shown that doses of 2-8 micrograms kg-1 of tetrapeptide inhibited 50-70% of the hepatocyte G1-S transitions.
Lombard
M N
MN
Institut Curie, Centre Universitaire, Orsay, France.
Sotty
D
D
Wdzieczak-Bakala
J
J
Lenfant
M
M
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D007399:Interphase / Q000187:drug effects; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009842:Oligopeptides; D004247:DNA; C058504:goralatide