[Lipid peroxidation and disorders of erythrocyte properties in patients with mechanical jaundice].
Changes in the activity of lipid peroxidation (LPO) and the attendant disorders of the properties of the red cells were studied from the results of examination of 32 patients with obstructive jaundice. The data obtained showed that the LPO processes were markedly activated, which led to changes of the red cell membrane properties--reduction of their electric charge, osmotic resistance, and deformity. All this led to metabolic shifts promoting cell destruction. The efficacy of hemosorption was due to sorption of the LPO toxic products rather than to the removal of bilirubin.
Petukhov
E B
EB
Filimonov
M I
MI
Aleksandrova
N P
NP
Korneev
A A
AA
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000378:metabolism*; D004907:Erythrocyte Deformability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008315:Malondialdehyde / Q000097:blood; D008564:Membrane Potentials / Q000502:physiology; D008875:Middle Aged; D009996:Osmotic Fragility
D008315:Malondialdehyde
Perekisnoe okislenie lipidov i narushenie svoĭstvéritrotsitov u bol'nykh s mekhanicheskoĭ zheltukhoĭ.