Oliguria in patients with normal renal function.
Oliguria is common in critically ill patients and may result from prerenal, renal, and postrenal causes. Oliguria also frequently develops in patients with normal concentrations of blood urea nitrogen and creatinine. Most of these patients do not develop renal failure. The authors prospectively studied 100 patients admitted to the ICU to determine the etiology of oliguria in these patients. Eighteen patients (18%) developed oliguria (less than 0.33 ml.kg-1.h-1 X 2 h). Seven and eleven patients were felt on clinical assessment to be hypovolemic or normovolemic, respectively. Compared with the hypovolemic patients, the normovolemic oliguric patients had significantly lower serum osmolalities (278 +/- 3 vs. 290 +/- 5 mOsm/kg H2O) and serum sodium concentrations (138 +/- 3 vs. 132 +/- 1 mEq/l). In addition, normovolemic patients had significantly higher urine sodium concentrations (83 +/- 12 vs. 13 +/- 2 mEq/l), fractional excretion of sodium (1.14 +/- 0.2 vs. 0.15 +/- 0.03), and renal failure indices (1.5 +/- 0.3 vs. 0.21 +/- 0.04). ADH concentrations in six hypovolemic and six normovolemic patients were increased in both groups but not significantly different. The hypovolemic patients increased their urine output from 17 +/- 2 ml/h to greater than 0.5 ml.kg-1.h-1 following a 500-ml bolus of normal saline. The normovolemic oliguric patients remained oliguric following the saline bolus (13 +/- 2 to 19 +/- 3 ml/h). The authors conclude that oliguria is common in critically ill patients and results from renal hypoperfusion and ADH excess.(ABSTRACT TRUNCATED AT 250 WORDS)
Zaloga
G P
GP
Department of Anesthesia/Critical Care, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Hughes
S S
SS
D001002:Anuria / Q000503:physiopathology*; D001810:Blood Volume; D004231:Diuresis / Q000187:drug effects; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications / Q000188:drug therapy; D007668:Kidney / Q000503:physiopathology*; D009846:Oliguria / Q000209:etiology / Q000503:physiopathology*; D009994:Osmolar Concentration; D012016:Reference Values; D012965:Sodium Chloride / Q000494:pharmacology; D014667:Vasopressins / Q000097:blood
D014667:Vasopressins; D012965:Sodium Chloride; D005665:Furosemide