Potential use of long-acting injectable oxytetracycline for treatment of chlamydiosis in Goffin's cockatoos.
To determine the potential use of parenteral therapy in the treatment of chlamydiosis in psittacine birds, the disposition and toxicity of a long-acting oxytetracycline (OTC) was evaluated in Goffin's cockatoos. Following intramuscular and subcutaneous administration of 50 to 100 mg/kg body weight, plasma OTC concentrations of 7 to 15 micrograms/ml were obtained 3 hr following injection and declined with a terminal half-life between 8.9 to 14.7 hr. Plasma concentrations in excess of 1.0 microgram/ml were maintained for 48 to 68 hr. Multiple-dose treatment of 100 mg/kg subcutaneously every 3 days for 30 days caused focal necrosis and scabs at the injection site but no other clinical or serological evidence of adverse effects. Long-term treatment did not result in accumulation or alteration in the disposition of OTC. Based on this study, a dosage regimen of 50 to 100 mg/kg of OTC subcutaneously every 2-3 days would safely maintain plasma concentrations in excess of 1.0 microgram/ml and could potentially be used as an alternative to medicated feeds or daily oral dosing regimens for the treatment of chlamydiosis in psittacine birds.
Flammer
K
K
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Aucoin
D P
DP
Whitt
D A
DA
Styles
D K
DK
D000818:Animals; D001715:Bird Diseases / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011563:Psittaciformes; D009956:Psittacosis / Q000188:drug therapy / Q000662:veterinary*
D003692:Delayed-Action Preparations; D010118:Oxytetracycline