A Dictyostelium discoideum mutant exhibiting calcium-dependent, high-level detergent resistance.
We report the isolation of a mutant of the cellular slime mold Dictyostelium discoideum that is highly resistant to the lethal action of the nonionic detergent Triton X-100. The resistance is completely dependent on the presence of divalent cations, of which Ca2+ is the most effective.
Madigan
S J
SJ
Department of Microbiology, State University of New York, Stony Brook 11794.
Whitbread
J A
JA
Katz
E R
ER
D002122:Calcium Chloride / Q000494:pharmacology*; D002413:Cations, Divalent; D003902:Detergents / Q000494:pharmacology*; D004023:Dictyostelium / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D004351:Drug Resistance / Q000235:genetics; D009154:Mutation; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000494:pharmacology*
D002413:Cations, Divalent; D003902:Detergents; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D017830:Octoxynol; D002122:Calcium Chloride