Cytogenetics of carcinoma in situ of the testis.
Carcinoma in situ (CIS) of the testis is the precursor lesion of most testicular germ cell tumors (TGCTs). Karyotyping of CIS is important for a better understanding of the pathogenesis of TGCTs and the progression to invasive cancer. We karyotyped three cases of CIS. All three cases showed a numerical abnormal chromosomal pattern. In one case, two copies of the germ cell tumor marker i(12p) were found.
Vos
A
A
Department of Medical Genetics, State University of Groningen, The Netherlands.
Oosterhuis
J W
JW
de Jong
B
B
Buist
J
J
Schraffordt Koops
H
H
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008297:Male; D009361:Neoplasm Invasiveness; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology
D014408:Biomarkers, Tumor