title: Effect of the glucocorticoid milieu on the immunostaining of peptide histidine isoleucine (PHI) in the rat hypothalamus.
abstract: Effects of adrenalectomy (ADX) or dexamethasone (DEX) treatment on the immunostaining of hypothalamic peptide histidine isoleucine (PHI) were examined in male rats. After colchicine treatment, PHI-containing cell bodies were observed in the suprachiasmatic nucleus (SCN) and the parvocellular division of the paraventricular nucleus (PVN). ADX increased and DEX dose-dependently decreased the number of PHI-immunopositive neurons in the PVN. The number of SCN-PHI neurons was not affected by any treatment employed in this study. These results suggest that PVN-PHI neurons are under the effects of the glucocorticoid milieu, and that the neurons may be involved in the glucocorticoid regulation of adrenocorticotropin and prolactin secretion.
authors.affiliation: Third Department of Internal Medicine, Hirosaki University, School of Medicine, Aomori, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanobe
authors.forename: K
authors.initials: K
authors.lastname: Takebe
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000502:physiology*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D010451:Peptide PHI / Q000378:metabolism*; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D010451:Peptide PHI; D003907:Dexamethasone