title: [Use of the stable nitrogen isotope 15N in assessing liver metabolism in hormonal contraception].
abstract: In 37 women with long-term use of oral contraceptives (average use 13.4 years) and 12 women who had not taken oral contraceptives for at least 5 years we determined the serum enzymes ALAT, ASAT, Gamma-GT and conducted the 15N-ammonium test as a marker of partial metabolic performance of the liver. In addition we studied total protein, protein fractions in the serum and haematologic parameter. 18 out of 37 women showed a morbid result in the 15N-ammonium test. In 4 of these 18 women morphological changes representing hepatic damage caused by contraceptives could be detected. On the average ALAT, Gamma-GT and 15N-ammonium test in both groups are clearly different. Because the enzymic levels are being in the normal range, only the 15N ammonium test enables to give a hepatotoxic evidence. It is possible to conclude that long-term use of oral contraceptives influences the liver metabolism.
authors.affiliation: Poliklinik, Bezirkskrankenhauses, Leipzig.
authors.forename: C
authors.initials: C
authors.lastname: Metzner
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: R
authors.initials: R
authors.lastname: Laue
authors.forename: C
authors.initials: C
authors.lastname: Wagenknecht
authors.forename: H J
authors.initials: HJ
authors.lastname: Graubaum
authors.forename: D
authors.initials: D
authors.lastname: Kranz
authors.forename: P
authors.initials: P
authors.lastname: Seifert
mesh_terms: D000328:Adult; D000641:Ammonia / Q000652:urine; D000643:Ammonium Chloride; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008111:Liver Function Tests / Q000379:methods*; D009587:Nitrogen Isotopes
chemical_list: D003278:Contraceptives, Oral, Hormonal; D009587:Nitrogen Isotopes; D000643:Ammonium Chloride; D000641:Ammonia
vernacular_title: Einsatz des stabilen Stickstoffisotops 15N zur Beurteilung des Leberstoffwechsels bei hormonaler Kontrazeption.