Cow milk and insulin-dependent diabetes mellitus: is there a relationship?
Various cow-milk preparations have, with some variation, been reported to be diabetogenic in two animal models of insulin-dependent diabetes mellitus (IDDM), the BioBreeding (BB) rat and the nonobese diabetic (NOD) mouse. However, the suggestion of an inverse relationship between breast-feeding and IDDM based on epidemiological studies, remains controversial. There is a significant positive correlation between consumption of unfermented milk protein and incidence of IDDM in data from various countries. Conversely, a possible negative relationship is observed between breast-feeding at age 3 mo and IDDM risk. Diet may be an important permissive factor in the development of IDDM.
Scott
F W
FW
Nutrition Research Division Food Directorate, Health & Welfare Canada, Ottawa Ontario.
D000367:Age Factors; D000818:Animals; D001208:Asia; D001942:Breast Feeding; D002417:Cattle; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D004195:Disease Models, Animal; D005060:Europe; D005260:Female; D005285:Fermentation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D051379:Mice; D008892:Milk / Q000009:adverse effects*; D008894:Milk Proteins / Q000009:adverse effects; D051381:Rats; D012307:Risk Factors; D014481:United States
D008894:Milk Proteins