title: [Basic and clinical aspects of tumor markers--with special reference to CEA].
abstract: Recent advances in carcinoembryonic antigen (CEA) research were reviewed. The primary structure of CEA peptide, mode of membrane anchoring of CEA, heterogeneity of carbohydrate chains, which seemed to be a main cause of the variations in CEA titers of patient's sera, and a newly established monoclonal radioimmunoassay system that revealed very homogeneous reactions with all CEA preparations and improved results on clinical applications were described. Furthermore, a recent finding that CEA is produced by normal colon mucosa as actively as by cancerous tissue was discussed.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
mesh_terms: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen