A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals.
The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.
Piven
J
J
Department of Psychiatry, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
Gayle
J
J
Chase
G A
GA
Fink
B
B
Landa
R
R
Wzorek
M M
MM
Folstein
S E
SE
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D007360:Intelligence; D008297:Male; D019965:Neurocognitive Disorders / Q000235:genetics*; D012307:Risk Factors; D012917:Social Adjustment