Calcium uptake activity of cardiac sarcoplasmic reticulum in myo-inositol-treated diabetic rats.
1. Cardiac function of STZ-diabetic rats has been shown to be partially improved by myo-inositol treatment. We studied the effect of myo-inositol on Ca2(+)-uptake activity in sarcoplasmic reticulum in diabetic animals. 2. Cardiac sarcoplasmic reticulum Ca2(+)-uptake activity was significantly depressed in 8-week diabetic rats. 3. Myo-inositol treatment could not improve Ca2(+)-uptake activity in diabetic rats. 4. The data suggest that the cardiac dysfunction in diabetic rats is due to factors other than the decreased Ca2(+)-uptake activity in sarcoplasmic reticulum.
Xiang
H
H
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
McNeill
J H
JH
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D007294:Inositol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*
D007294:Inositol; D000255:Adenosine Triphosphate; D002118:Calcium