Cranial nerve dysfunction in conscious galactosemic rats as measured by the auditory-evoked brainstem response.
The purpose of this study was to extend our previous work with the auditory-evoked brainstem response and determine whether galactosemia would produce a functional neuropathy similar to that previously seen in streptozocin-induced diabetic rats. Sprague-Dawley male rats implanted with cortical electrodes received either normal chow (n = 17) or a 50% galactose diet (n = 17) for 5 weeks. Peak II latency of the auditory-evoked brainstem response, interpreted as a functional measure of the auditory nerve (VIII cranial) in rats, was significantly prolonged in galactose-fed rats relative to controls (P less than 0.05). These results demonstrate a functional deficit in the auditory nerves of galactosemic rats. The deficit in the auditory-evoked brainstem response of galactosemic rats is similar to our previous finding in streptozocin-induced diabetic rats.
Notvest
R R
RR
Wyeth-Averst Research, Inc., Department of Experimental Therapeutics, Princeton, New Jersey 08543-8000.
Inserra
J J
JJ
Emrey
T A
TA
Sredy
J
J
D000818:Animals; D001933:Brain Stem / Q000503:physiopathology; D002386:Cataract / Q000209:etiology; D005072:Evoked Potentials, Auditory; D005693:Galactosemias / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000159:Vestibulocochlear Nerve / Q000503:physiopathology*