Dietary fish oils limit adipose tissue hypertrophy in rats.
Total body mass, fat pad mass, and fat cell size were examined after feeding rats diets containing 20% triglycerides from fish oil or lard. Although food consumption, weight gain, and fat balance on the two diets were similar, lard-fed rats had 77% more fat in perirenal fat pads and 51% more fat in epididymal fat pads compared with fish oil-fed rats. There was no difference between the two groups in fat cell number in each region; however, adipocytes were significantly smaller in fish oil-fed rats. Thus dietary fish oil appears to limit triglyceride accumulation in adipose tissue and thereby limit fat cell trophic growth.
Parrish
C C
CC
Department of Medicine, University of Toronto, Ontario, Canada.
Pathy
D A
DA
Angel
A
A
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D005395:Fish Oils / Q000494:pharmacology*; D006984:Hypertrophy / Q000517:prevention & control; D007408:Intestinal Absorption; D008055:Lipids / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D004041:Dietary Fats; D005395:Fish Oils; D008055:Lipids; D014280:Triglycerides; C029310:lard