Effect of bismuth subsalicylate on chronic diarrhea in childhood: a preliminary report.
Stools collected from 39 infants and children with chronic nonspecific diarrhea and from 10 age-matched controls were examined for bile acid content with use of gas-liquid chromatography. Values were correlated with stool color. Mean concentration of bile acids in green stools (7.7 +/- 1.52 mg/g dry weight) was significantly higher than that in brown stools (3.76 +/- 0.7 mg/g dry weight) and in control stools (1.42 +/- 0.35 mg/g dry weight). In patients with green diarrhea, treatments with cholestyramine and bismuth subsalicylate (Pepto-Bismol) were equally effective in decreasing stool frequency, with the latter being more effective in decreasing water content. Patients with brown stools had an insignificant response to therapy.
Gryboski
J D
JD
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510-8064.
Kocoshis
S
S
D001647:Bile Acids and Salts / Q000032:analysis; D001729:Bismuth / Q000627:therapeutic use*; D002675:Child, Preschool; D002792:Cholestyramine Resin / Q000627:therapeutic use; D002849:Chromatography, Gas; D002908:Chronic Disease; D003967:Diarrhea / Q000188:drug therapy*; D005243:Feces / Q000032:analysis; D006801:Humans; D007223:Infant; D009942:Organometallic Compounds / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*
D001647:Bile Acids and Salts; D009942:Organometallic Compounds; D012459:Salicylates; D002792:Cholestyramine Resin; C015715:bismuth subsalicylate; D001729:Bismuth