Influence of corticosterone on tracheal mucociliary transport in pigeons.
The effects of corticosteroids on tracheal mucociliary transport (MCT) were examined in pigeons. Intramuscular administration of corticosterone had no effect at 1.0 mg/kg, while at a larger dose of 5.0 mg/kg, it slightly, but significantly increased the MCT rate. Metyrapone significantly decreased the MCT rate, and the inhibitory action was blocked by 1.0 mg/kg corticosterone. The present study suggested that corticosteroids modulated the mucociliary clearance, especially under some diseases associated with a decreased level of endogenous corticosteroids.
Kai
H
H
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Yamamoto
S
S
Takahama
K
K
Miyata
T
T
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D010856:Columbidae / Q000502:physiology*; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D008797:Metyrapone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
D003345:Corticosterone; D008797:Metyrapone