title: Hepatic haemodynamic changes after portacaval anastomosis in normal, cirrhotic and chronic prehepatic portally hypertensive rats.
abstract: Radioactive microspheres were used to determine the hepatic haemodynamic response to portacaval anastomosis in normal, cirrhotic and chronic prehepatic portally hypertensive rats 20 days after operation, and in normal rats 2 months after operation. After 20 days portacaval anastomosis caused a decrease in liver mass only in normal and cirrhotic animals, whereas hepatic arterial blood flow per unit of mass increased in normal (+488 per cent), cirrhotic (+191 per cent) and prehepatic portally hypertensive rats (+133 per cent). Despite these facts, animals with portacaval anastomosis showed a reduced hepatic total perfusion (arterial plus portal inflow) per unit of mass with respect to controls in normal (-53 per cent) and cirrhotic rats (-68 per cent), but not in those with prehepatic portal hypertension. Comparing studies carried out at 2 months with those performed 20 days after portacaval anastomosis in normal rats, some recovery of liver mass and total liver blood flow was observed. In conclusion, portacaval anastomosis produced a limited increase in hepatic arterial blood flow which was unable to preserve liver mass and its total perfusion in normal and cirrhotic animals. In contrast, portacaval anastomosis did not significantly alter liver mass or its perfusion in animals with chronic prehepatic portal hypertension, as both values were previously diminished in controls. Thus, the risk of liver failure after portacaval anastomosis is higher in normal and cirrhotic rats than in those with chronic prehepatic portal hypertension.
authors.affiliation: Department of Surgery, Fundacion Jimenez Diaz-CSIC, Universidad Autonoma de Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Romeo
authors.forename: A
authors.initials: A
authors.lastname: Lopez-Farre
authors.forename: V
authors.initials: V
authors.lastname: Martin-Paredero
authors.forename: J M
authors.initials: JM
authors.lastname: Lopez-Novoa
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002908:Chronic Disease; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000503:physiopathology* / Q000601:surgery; D008099:Liver / Q000503:physiopathology; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D009929:Organ Size; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013152:Splanchnic Circulation; D013997:Time Factors; D014655:Vascular Resistance