title: Production and investigating of tablets containing furosemide and beta-cyclodextrin.
abstract: Furosemide is a very active drug with an excellent saluretic effect, but it dissolves in water only with difficulty. Furosemide products with beta-cyclodextrin (CD) have been made by five methods, and it has been established that most drugs are liberated most quickly from the kneaded product for the 12.72% combinations. The dissolution characteristics of furosemide are improved in tablets made from the kneaded product. By this means an essentially quicker effect can be achieved, a lower drug quantity is necessary for a similar effect, a smaller therapeutic risk in involved, and the technique is economical too.
authors.forename: M
authors.initials: M
authors.lastname: Kata
authors.forename: L
authors.initials: L
authors.lastname: Haragh
authors.forename: K
authors.initials: K
authors.lastname: Pintye-Hódi
mesh_terms: D003505:Cyclodextrins; D003912:Dextrins; D004338:Drug Combinations; D005665:Furosemide; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007700:Kinetics; D012995:Solubility; D013213:Starch; D013607:Tablets; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D003912:Dextrins; D004338:Drug Combinations; D013607:Tablets; D047392:beta-Cyclodextrins; D005665:Furosemide; D013213:Starch; C031215:betadex