title: NMR spectral analysis of kinetic data using natural lineshapes.
abstract: An automated rapid data analysis scheme for NMR spectroscopy time course studies is presented. This method uses a high signal-to-noise reference spectrum collected at the beginning of a time course as a lineshape model to analyze subsequent low signal-to-noise data collected with higher time resolution. The method is fast (approximately 1 s to evaluate two peaks in a 2K spectrum) and easily implemented on NMR spectrometer computers. An application of this method to spectroscopic studies on the heart is provided.
authors.affiliation: Laboratory of Cardiac Energetics, National Heart Blood and Lung Institute, Bethesda, Maryland 20892.
authors.forename: F W
authors.initials: FW
authors.lastname: Heineman
authors.forename: J
authors.initials: J
authors.lastname: Eng
authors.forename: B A
authors.initials: BA
authors.lastname: Berkowitz
authors.forename: R S
authors.initials: RS
authors.lastname: Balaban
mesh_terms: D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008961:Models, Structural; D013997:Time Factors