title: Carbon catabolite regulation of phenylacetyl-CoA ligase from Pseudomonas putida.
abstract: Phenylacetyl-CoA ligase (PA-CoA ligase) from P. putida U is a newly described enzyme involved in the aerobic catabolism of phenylacetic acid. The enzyme was specifically induced when P. putida was grown in a chemically defined medium containing phenylacetic acid as the sole carbon source. The induction of PA-CoA ligase was delayed by adding easily metabolizable carbon sources to the medium; the effect was more drastic in the presence of glucose. Glucose did not cause catabolic inactivation but rather catabolic repression, this effect being reversed by cAMP.
authors.affiliation: Departamento Interfacultativo de Bioquimica y Biologia Molecular, Universidad de León, España.
authors.forename: H
authors.initials: H
authors.lastname: Martinez-Blanco
authors.forename: A
authors.initials: A
authors.lastname: Reglero
authors.forename: J M
authors.initials: JM
authors.lastname: Luengo
mesh_terms: D000332:Aerobiosis; D050260:Carbohydrate Metabolism; D002701:Chloramphenicol / Q000494:pharmacology; D003066:Coenzyme A Ligases / Q000096:biosynthesis*; D004790:Enzyme Induction; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D010648:Phenylacetates / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development
chemical_list: D010648:Phenylacetates; D002701:Chloramphenicol; D003066:Coenzyme A Ligases; C023914:phenylacetate - CoA ligase; C025136:phenylacetic acid; D005947:Glucose