Cocaine-induced cerebral vascular damage can be ameliorated by Mg2+ in rat brain.
Cocaine HCl (10 micrograms/ml) delivered perivascularly to the surface of the rat brain resulted in rapid contraction of pial arterioles, which reduced the diameters by 26% compared to controls. This was followed by venular vasospasm and rupture of postcapillary venules and micro-hemorrhages at postcapillary sites. Administration of Mg aspartate HCl, by intraarterial or intravenous infusion (1, 10 and 20 mumol/min), before or after the cocaine, produced dose-dependent inhibition (20-85%) of the cocaine-induced arteriolar spasms and prevention and attenuation of the venular vasculotoxicity and hemorrhaging. These data suggest that magnesium salts might be useful agents in the treatment of cocaine-induced intoxication and prevention of brain damage.
Huang
Q F
QF
Department of Physiology, State University of New York, Brooklyn 11203.
Gebrewold
A
A
Altura
B T
BT
Altura
B M
BM
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000139:chemically induced* / Q000188:drug therapy; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008274:Magnesium; D003042:Cocaine