Spinal tetracaine decreases central nervous system metabolism during somatosensory stimulation in the rat.
The influence of spinal tetracaine on central nervous system (CNS) metabolism was determined during nociceptive stimulation. Rats were divided into a halothane group in which the sciatic nerve was stimulated during 0.5 per cent halothane anaesthesia, a tetracaine group in which the sciatic nerve was stimulated during a simultaneous tetracaine spinal and 0.5 per cent halothane anaesthetic, or an awake group. Autoradiographic determination of local spinal cord and cerebral glucose utilization was performed using 14C-2-deoxyglucose. Central nervous system metabolism was greater in the halothane group than the tetracaine and awake groups (P less than 0.05). The only meaningful differences between the tetracaine and awake groups were in two lumbar grey areas at the site of drug administration where metabolism was decreased in the tetracaine/stimulated group. These results indicate that spinal tetracaine effects a decrease in metabolism locally, and attenuates increases in metabolism throughout the CNS observed during somatosensory stimulation.
Cole
D J
DJ
Department of Anesthesiology, Veteran's Administration Medical Center, San Diego, CA.
Lin
D M
DM
Drummond
J C
JC
Shapiro
H M
HM
D000704:Analysis of Variance; D000775:Anesthesia, Spinal; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006221:Halothane / Q000494:pharmacology; D008297:Male; D009619:Nociceptors / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013748:Tetracaine / Q000008:administration & dosage / Q000494:pharmacology*
D013748:Tetracaine; D005947:Glucose; D006221:Halothane