Potent oral anticonvulsant action of CPP and CPPene in DBA/2 mice.
CPP (3-(2-carboxypiperazine-4-yl)-1-phosphonate), and its unsaturated analogue, CPPene (3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid), have potent anticonvulsant activity against sound-induced clonic seizures in DBA/2 mice. Following i.p. administration the protection is maximal at 1-2 h, and the ED50 values (mumol/kg) are: D(-)-CPPene, 1.54; D(-)-CPP, 2.75; D,L( +/- )-CPP, 4.36. Following oral administration the protection is maximal at 3-4 h and the ED50 (mumol/kg) values are: D(-)-CPPene, 40.19; D(-)-CPP, 65.80; D,L( +/- )-CPP, 108.1.
Chapman
A G
AG
Department of Neurology, Institute of Psychiatry, De Crespigny Park, London, U.K.
Graham
J
J
Meldrum
B S
BS
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D051379:Mice; D008811:Mice, Inbred DBA; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control
D000927:Anticonvulsants; D009943:Organophosphorus Compounds; D010879:Piperazines; C065286:SDZ EAA 494; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid