title: Fatty acid control of growth of human cervical and endometrial cancer cells.
abstract: Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.
authors.affiliation: Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Gleeson
authors.forename: M
authors.initials: M
authors.lastname: Ayub
authors.forename: J T
authors.initials: JT
authors.lastname: Wright
authors.forename: C B
authors.initials: CB
authors.lastname: Wood
authors.forename: N A
authors.initials: NA
authors.lastname: Habib
authors.forename: W P
authors.initials: WP
authors.lastname: Soutter
authors.forename: M H
authors.initials: MH
authors.lastname: Sullivan
authors.forename: J O
authors.initials: JO
authors.lastname: White
mesh_terms: D002455:Cell Division / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D013229:Stearic Acids / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D013229:Stearic Acids; D004815:Epidermal Growth Factor