Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells.
Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis.
Békássy
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AN
Department of Pediatrics, University Hospital, Lund, Sweden.
Liliemark
J
J
Garwicz
S
S
Wiebe
T
T
Gulliksson
H
H
Peterson
C
C
D001085:Arabinofuranosylcytosine Triphosphate / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D001088:Arabinonucleotides / Q000134:cerebrospinal fluid*; D002404:Catheterization; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007276:Injections, Intraventricular; D008159:Lumbar Vertebrae; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000473:pathology; D013997:Time Factors
D001088:Arabinonucleotides; D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D006854:Hydrocortisone