title: Nickel-sensitive patients with vesicular hand eczema: oral challenge with a diet naturally high in nickel.
abstract: Oral challenge with nickel sulphate indicated that vesicular hand eczema in nickel-sensitive patients may be exacerbated by nickel occurring naturally in the diet. Twelve nickel-sensitive females with vesicular hand eczema were challenged with a supplementary high nickel diet for 4 days in a single-blind cross-over study. The diet had about five times the average nickel content of the daily Danish diet. An aggravation of the hand eczema was observed in six out of 12 patients on day 4 after the start of the challenge. By day II, the hand eczema was worse in 10 out of 12 patients, and remained unchanged in two.
authors.affiliation: Department of Environmental Medicine, Odense University Hospital, Denmark.
authors.forename: G D
authors.initials: GD
authors.lastname: Nielsen
authors.forename: L V
authors.initials: LV
authors.lastname: Jepsen
authors.forename: P J
authors.initials: PJ
authors.lastname: Jørgensen
authors.forename: P
authors.initials: P
authors.lastname: Grandjean
authors.forename: F
authors.initials: F
authors.lastname: Brandrup
mesh_terms: D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000209:etiology* / Q000652:urine; D004032:Diet / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000209:etiology* / Q000652:urine; D006801:Humans; D008875:Middle Aged; D009532:Nickel / Q000008:administration & dosage* / Q000009:adverse effects / Q000652:urine; D011897:Random Allocation; D016037:Single-Blind Method
chemical_list: D009532:Nickel