[Determination of the oxidation phenotype in the Czechoslovak population using metoprolol].
The authors assessed the oxidative phenotype type debrisochin/spartein in 97 healthy volunteers aged 23 to 56 years (45 men and 52 women). After metoprolol administration which served as a model substance, in doses of 100 mg p. o. at night, the authors collected urine during 8 hours. In the urine specimens they assessed by gas chromatography with detection of the electron capture (fig. 1) the metabolic ratio of metoprolol/alpha-hydroxymetoprolol (M/HM). The distribution of logM/HM on the frequency histogram was bimodal and made it possible to divide the group into extensive and poor metabolizers (fig. 2). The authors detected 6 poor metabolizers which corresponds to the results in the white population. The authors discuss the clinical impact of oxidative polymorphism in the treatment with metoprolol, diltiazem, quinidine and other drugs.
Ulc
I
I
Výzkumný ústav pro farmacii a biochemii, Praha.
Ulc
J
J
Cepeláková
H
H
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype
D008790:Metoprolol
Stanovení oxidacního fenotypu metoprolem v nasí populaci.