[Plasma and urine catecholamines in a 7-day survival of parathion poisoning].
During the intensive medical treatment of a finally fatal parathion poisoning (survival time 7 days) with shock symptoms (lung and kidney) the kinetic profiles of both plasma and urinary catecholamines were taken up. In addition the parathion concentrations of the same plasma samples were measured. There could have been found plasma catecholamine profiles exhibiting peak concentrations in the initial phase, followed by a period of 4 days without any detectable plasma epinephrine and finally an extreme elevation of both catecholamines in the last period before death. The excretion patterns confirmed the plasma results. Imaginable pathophysiological mechanisms in consideration of the shock induced renal insufficiency are discussed. The question is raised whether the kinetics of plasma catecholamines may be a possible marker for the prognosis of organophosphate poisoning.
Kauert
G
G
Institut für Rechtsmedizin der Universität München.
Schoppek
B
B
von Clarmann
M
M
Felgenhauer
N
N
D000368:Aged; D002802:Cholinesterases / Q000378:metabolism; D062787:Drug Overdose / Q000201:enzymology*; D004837:Epinephrine / Q000378:metabolism*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010278:Parathion / Q000493:pharmacokinetics / Q000506:poisoning*
D010278:Parathion; D002802:Cholinesterases; D009638:Norepinephrine; D004837:Epinephrine
Plasma- und Urin-Katecholamine bei einer 7 Tage überlebten Parathion-Intoxikation.