title: Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat.
abstract: BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria (greater than 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in both combinations of crosses.
authors.affiliation: Second Department of Pathology, Nagoya University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsuyama
authors.forename: T
authors.initials: T
authors.lastname: Ogiu
authors.forename: K
authors.initials: K
authors.lastname: Kontani
authors.forename: C
authors.initials: C
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Hiai
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: F
authors.initials: F
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Toyokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000419:Albuminuria / Q000652:urine; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005808:Genes, Recessive; D005921:Glomerulonephritis / Q000235:genetics*; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains