Immunologic conditions and infectious complications in colon and rectal surgery for neoplasms.
The authors evaluated the peroperative immunologic state of patients with colorectal tumors and controlled the postoperative incidence of infections. Twenty-one patients were studied, and delayed type hypersensitivity reactivity determined by the CMI multitest (Merieux) eight days before and eight days after surgery. A lymphocytogram was performed using monoclonal antibodies. A significant percentage of patients were anergic preoperatively. Immunologic analysis revealed lymphocytosis in the first postoperative period. The largest absolute quantitative increase was shown by NK CD16+ cells. It is possible that the results, obtained by dynamic monitoring of the main parameters of cellular immunity, will offer a new way for prognostic evaluation of surgical risk.
Fragapane
P
P
General Surgery Division, Mauriziano Hospital, Torino, Italy.
Varvello
G
G
Bossotti
M
M
Vergara
V
V
Poccardi
G
G
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007239:Infections / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology