title: Combined ionizing radiation and thermal injury in the rat. Evaluation of early excision and closure of the burn wound.
abstract: The present study was undertaken to establish an animal model of combined whole-body irradiation and thermal injury and to determine the effectiveness of early excision and closure of the burn wound in such a model. Whole-body irradiation over a range of doses resulted in a predictable mortality rate, with an LD50/30 of 783 rad with 95% confidence limits of 737 and 823 rad. A controlled 10% body surface area full-thickness thermal injury resulted in no deaths in 30 animals. When combined with a standard nonlethal 10% thermal injury, varying doses of whole-body irradiation resulted in widely differing LD50/30 values in three separate cohorts of rats. Excision and closure of a 10% burn 24 hours after exposure to 200 rads did not improve survival. (J BURN CARE REHABIL 1990;11:42-5)
authors.affiliation: Department of Surgery, Boston University School of Medicine, Massachusetts.
authors.forename: E F
authors.initials: EF
authors.lastname: Hirsch
authors.forename: R
authors.initials: R
authors.lastname: Vezina
authors.forename: S
authors.initials: S
authors.lastname: Corbett
authors.forename: W
authors.initials: W
authors.lastname: LaMorte
authors.forename: M
authors.initials: M
authors.lastname: Feldman
mesh_terms: D000818:Animals; D002056:Burns / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D008297:Male; D011832:Radiation Injuries / Q000401:mortality / Q000601:surgery*; D011839:Radiation, Ionizing; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors