Epidermal growth factor receptor mRNA is not increased in psoriatic skin.
Poly(A)+mRNAs were purified from the skin sheets of five psoriatic patients and three healthy individuals, and mRNA expression of epidermal growth factor (EGF) receptor gene was studied by Northern-blot technique using a cDNA probe of the whole EGF-receptor gene. Both psoriatic and normal skin had 5.3-kb and 11.0-kb mRNAs of the EGF-receptor gene. There existed no clear differences in the mRNA levels between psoriasis and normal controls. Since Nanney et al. has reported an increased number of EGF-receptors in active lesions of psoriasis, it has been speculated that the production of EGF-receptors is not increased, but rather that the down-regulation may be decreased, in psoriatic skin, resulting in the increased number of EGF-receptors.
Kobayashi
H
H
Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan.
Yasuda
H
H
Matsue
H
H
Ohkawara
A
A
Ogiso
Y
Y
Kuzumaki
N
N
D000199:Actins / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis*; D012867:Skin / Q000032:analysis*
D000199:Actins; D012333:RNA, Messenger; D066246:ErbB Receptors