Efficacy of ACC-9653 (a phenytoin prodrug) in experimental status epilepticus in the rat.
Status epilepticus was induced by injection of homocysteine thiolactone to rats with epileptogenic cortical cobalt lesions. Either standard phenytoin or ACC-9653 (a phenytoin prodrug) was injected after the second generalized tonic-clonic seizure. Rats treated with ACC-9653 had significantly poorer treatment outcomes than rats treated with standard phenytoin, although no differences were found in the concentration of phenytoin in plasma or brain 65 min after injection.
Walton
N Y
NY
Neurology and Research Services, West Los Angeles Veterans Administration Medical Center, CA.
Treiman
D M
DM
D000818:Animals; D008297:Male; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011355:Prodrugs / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D011355:Prodrugs; D010672:Phenytoin; C043114:fosphenytoin