Retrograde amnesia produced by intrastriatal atropine and its reversal by choline.
A number of studies have shown that cholinergic blockade of the striatum produces amnesia. In the present experiment it was predicted that by increasing the synthesis of striatal acetylcholine such amnesic state would be prevented. Atropine was injected into the striatum of rats before training of passive avoidance; some of these rats were also injected, intrastriatally, with choline before testing the retention of the task. Atropine alone produced amnesia while the combination of treatments reversed this effect.
Solana-Figueroa
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Faculty of Medicine, Physiology Department, National University of México, México, D.F.
Prado-Alcalá
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RA
D000109:Acetylcholine / Q000096:biosynthesis; D000647:Amnesia / Q000517:prevention & control*; D000648:Amnesia, Retrograde / Q000139:chemically induced / Q000517:prevention & control*; D000704:Analysis of Variance; D000818:Animals; D001285:Atropine / Q000037:antagonists & inhibitors*; D001362:Avoidance Learning / Q000187:drug effects; D002794:Choline / Q000494:pharmacology* / Q000627:therapeutic use; D003342:Corpus Striatum / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D001285:Atropine; D002794:Choline; D000109:Acetylcholine