Action of retinoids during transformation of 10T1/2 cells.
The effect of three retinoids, 13-cis-retinoic acid, arotinoid ethyl sulfone and retinal acetate, on methylcholanthrene (MCA) induced transformation of 10T1/2 cells was studied. It appears that 13-cis-retinoic acid and arotinoid ethyl sulfone prevent transformation in a direct way at the last stage of carcinogenesis. Retinal acetate, however, requires cell-to-cell contacts to inhibit the transformation of 10T1/2 cells.
Przybyszewska
M
M
Department of Tumor Biology, M. Skłodowska-Curie Institute of Oncology, Warsaw, Poland.
Janik
P
P
Miłoszewska
J
J
Szaniawska
B
B
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D004224:Diterpenes; D008748:Methylcholanthrene; D051379:Mice; D012176:Retinoids / Q000494:pharmacology*; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D004224:Diterpenes; D012176:Retinoids; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D008748:Methylcholanthrene; D014212:Tretinoin; C045042:Ro 15-1570