Evaluation of flurbiprofen-exposed irises to acetylcholine anterior chamber irrigation.
Flurbiprofen (Ocufen), an antiprostaglandin, has been introduced into cataract surgery. It is used to prevent intraoperative miosis by blocking inflammatory mediator formation. Ocufen has been noted to diminish the controlled miosis produced by using acetylcholine in the operative period. This study evaluated the pupillary response to acetylcholine after it had been exposed to Ocufen. This was done using a control versus a study eye in 16 rabbits dilated with phenylephrine hydrochloride and cyclopentolate hydrochloride. The pupil diameters were measured at baseline, then the rabbits' anterior chambers were irrigated with an acetylcholine solution. The resultant pupillary diameters were measured at one and five minutes. At five minutes post-irrigation there was a statistically significant greater constriction in the control group than in the Ocufen group. This implies that Ocufen dampens the iris musculature's response to acetylcholine.
Ozog
M F
MF
Loyola University, Stritch School of Medicine, Maywood, Illinois 60153.
Zimm
J L
JL
Park
R
R
Fisher
S
S
Fort
C
C
McDonald
J E
JE
D000109:Acetylcholine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005480:Flurbiprofen / Q000494:pharmacology*; D007432:Intraoperative Period; D007498:Iris / Q000187:drug effects*; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D007507:Therapeutic Irrigation; D013997:Time Factors
D005480:Flurbiprofen; D000109:Acetylcholine