[The clinico-functional effectiveness of calcium antagonists in correcting the bronchial hyperreactivity of bronchial asthma patients].
In 46 bronchial asthma (BA) patients, a study was made of the effects of calcium antagonists (CA) (corinfar, perdipine) on bronchial sensitivity and reactivity determined on bronchospasm induction with the increasing doses of acetylcholine. A single intake of 20 mg of a CA in BA patients significantly improved bronchial sensitivity and reactivity (the rise of the PD25 and the decline of the alpha angle). 20 patients were treated with corinfar for two weeks after administration of the basic therapy. As a result, the clinical status as well as bronchial sensitivity and reactivity improved in the majority of BA patients. While assessing the efficacy of the treatment with corinfar after half a year it was established that in 9 out of 13 BA patients, the PD25 increased and the alpha angle diminished. Thus, CA reduce bronchial hypersensitivity and hyperreactivity to acetylcholine in BA patients.
Fedoseev
G B
GB
Sinitsina
T M
TM
Shchemelinina
T I
TI
D000109:Acetylcholine; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000295:instrumentation / Q000379:methods; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D009543:Nifedipine / Q000008:administration & dosage
D001993:Bronchodilator Agents; D002121:Calcium Channel Blockers; D009543:Nifedipine; D000109:Acetylcholine
Kliniko-funktsional'naia éffektivnost' antagonistov kal'tsiia pri korrektsii giperreaktivnosti bronkhov u bol'nykh bronkhial'noĭ astmoĭ.