Determination of anti-cardiolipin and other antibodies in HIV-1-infected patients.
Anti-cardiolipin antibodies (ACA) were determined by an ELISA assay in 116 HIV-1-infected patients. A positive test was found in 27 patients (23.3%) with a predominance of IgG ACA isotype. No significant difference in ACA positivity was observed between homosexuals (22.2%) and intravenous drug users (25.8%). The presence of different immunological markers was compared in ACA-positive and ACA-negative patients: ACA-positive patients had higher IgG levels (p less than 0.05) and a tendency to higher frequencies of anti-ss DNA, anti-ds DNA, anti-i antibodies, as well as circulating immune complexes. When patients were classified according to CDC criteria, no significant difference was observed for the prevalence of ACA in class II (21.2%), in class III (25%), and in class IV (21%). Our results indicate that ACA antibodies occur with other immunological alterations in HIV-1-infected patients, but do not confirm that ACA is a useful prognostic marker for development of AIDS.
Bernard
C
C
Department of Medicine, University Cantonal Hospital, Geneva, Switzerland.
Exquis
B
B
Reber
G
G
de Moerloose
P
P
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D002308:Cardiolipins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M