Fish oils in hypertriglyceridemia: a dose-response study.
The effects of three supplemental doses of fish oil on plasma lipids, lipoproteins, and bleeding times were studied in ten hypertriglyceridemic patients. After a 3-wk baseline period each patient was given 15, 25, or 40 mL fish oil/d (containing 4.5, 7.5, and 12 g n-3 fatty acids) for three successive 6-wk periods, each separated by a 4-wk period of no supplementation. Plasma cholesterol concentrations decreased from 7.40 mmol/L to 6.35, 6.55, and 6.40 mmol/L with increasing doses of fish oil (p less than 0.01 vs baseline for each). Plasma triglyceride concentrations decreased from 6.10 mmol/L to 2.90, 2.80, and 2.35 mmol/L (p less than 0.01 vs baseline for each). Low-density-lipoprotein cholesterol concentrations increased significantly (by 23% and 28%) with the two higher doses, respectively. Bleeding times increased only with the largest dose. The lowest dose was the most hypolipidemic per gram n-3 fatty acids.
Harris
W S
WS
Division of Endocrinology, Metabolism and Clinical Nutrition, Oregon Health Sciences University, Portland.
Rothrock
D W
DW
Fanning
A
A
Inkeles
S B
SB
Goodnight
S H
SH
Illingworth
D R
DR
Connor
W E
WE
D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol