title: The sex difference in the regulation of liver regeneration after partial hepatectomy in the rat.
abstract: The increases in the activity of hepatic thymidylate synthetase and thymidine kinase, which catalyzes the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed 24 h after 70% partial hepatectomy in female rats administered either alpha- or beta-adrenoreceptor antagonists. The injection of beta-antagonist to male or ovariectomized female rats had no effect on the activities of these enzymes. Only alpha-adrenoceptor antagonist depressed these enzymatic activities of 24-h-regenerating liver in male and ovariectomized female rats. The decrease of the activities of thymidylate synthetase and thymidine kinase was accompanied by a concomitant reduction of DNA content in 24-h-regenerating liver. It is concluded that catecholamine regulates the female rat liver regeneration through both alpha- and beta-adrenergic pathways by the inductions of thymidylate synthase and thymidine kinase, while in adult male and ovariectomized female rats, only the alpha-mediated pathway is involved.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Tsukamoto
authors.forename: S
authors.initials: S
authors.lastname: Kojo
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000502:physiology; D004247:DNA / Q000378:metabolism; D005260:Female; D006498:Hepatectomy / Q000379:methods; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D010052:Ovariectomy; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
chemical_list: D002395:Catecholamines; D010643:Phenoxybenzamine; D004247:DNA; D011433:Propranolol; D013940:Thymidylate Synthase; D013937:Thymidine Kinase