[Preventive antibiotics in emergency cesarean section. A prospective comparison of benzylpenicillin and ampicillin plus cloxacillin].
Emergency cesarean section, especially when performed more than ten hours after rupture of the membranes, involves a high risk of postoperative infection. Different antibiotic regimens have been shown to reduce these infections substantially. In this prospective study a combination of ampicilling (2 g) plus kloxacillin (2 g) given as a single-dose infusion directly after division of the cord reduced the post-operative infection rate to 13% in a group of high-risk emergency cesarean section cases. Benzylpenicillin only (2 g) was less efficient. No side-effects were observed, and this prophylaxis may have certain advantages over cephalosporins, especially with respect to enterococcus-induced endometritis.
Fredriksson
A
A
Kvinnokliniken Karolinska, sjukhuset, Stockholm.
Thomassen
P
P
D000667:Ampicillin / Q000008:administration & dosage*; D002585:Cesarean Section / Q000009:adverse effects*; D003023:Cloxacillin / Q000008:administration & dosage*; D004338:Drug Combinations; D004630:Emergencies; D005260:Female; D006801:Humans; D010400:Penicillin G / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D011247:Pregnancy; D011300:Preoperative Care; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
D004338:Drug Combinations; D000667:Ampicillin; D003023:Cloxacillin; D010400:Penicillin G
Antibiotikaprofylax vid akut sectio caesarea. En prospektiv jämförelse mellan benzylpenicillin och ampicillin plus kloxacillin.