title: Chromosome abnormalities involving heterochromatic regions in monocytic leukemia.
abstract: We report two cases of monocytic leukemia associated with cytogenetic changes involving the juxtacentromeric heterochromatin of different chromosomes. In a patient with chronic myelomonocytic leukemia (CMMoL) we describe a translocation t(1;9)(q12;q13) in which the duplicated derivative chromosome 9q + showed a huge centromeric C-band, derived by fusion of the heterochromatic regions of chromosomes 1 and 9. The constitutional karyotype showed two heterochromatin polymorphisms, 1qh + and inv(9qh). In the second case, an acute monoblastic leukemia was associated with an abnormally elongated juxtacentromeric heterochromatic region of chromosome 4 that was not constitutionally present.
authors.affiliation: Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rege-Cambrin
authors.forename: S
authors.initials: S
authors.lastname: Kerim
authors.forename: P
authors.initials: P
authors.lastname: Scaravaglio
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: G
authors.initials: G
authors.lastname: Saglio
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D006570:Heterochromatin; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D006570:Heterochromatin