B-vitamins enhance afferent inhibitory controls of nociceptive neurons in the rat spinal cord.
Afferent inhibition of spinal dorsal horn neuronal responses to noxious skin heating was induced by transcutaneous electrical nerve stimulation in pentobarbital-anesthetized rats. Pretreatment with B vitamins significantly enhanced this afferent inhibition, possibly due to an increase in the synthesis rate of inhibitory neurotransmitters in central neurones.
Fu
Q G
QG
II. Physiologisches Institut der Universität Heidelberg.
Sandkühler
J
J
Zimmermann
M
M
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects*; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013697:Thermosensing / Q000187:drug effects; D013979:Tibial Nerve / Q000187:drug effects; D014803:Vitamin B Complex / Q000494:pharmacology*
D014803:Vitamin B Complex