title: Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.
abstract: The pharmacokinetics of Zn-phthalocyanine (Zn-Pc) in mice bearing a transplanted MS-2 fibrosarcoma has been studied using dipalmitoyl-phosphatidylcholine (DPPC) liposomes and low density lipoproteins (LDL) as drug delivery systems. LDL induce a higher Zn-Pc uptake by the tumour and improve the selectivity of tumour targeting as compared to DPPC liposomes. Experimental photodynamic therapy (PDT) of the MS-2 fibrosarcoma has been performed using liposome-delivered Zn-Pc and the efficiency of tumour necrosis has been measured following four different irradiation protocols. We found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose. The amount of Zn-Pc in the tumour decreases very slowly as a function of time, hence PDT gives satisfactory results even if performed at relatively long time intervals after administration.
authors.affiliation: Department of Biology, University of Padova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Reddi
authors.forename: C
authors.initials: C
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Biolo
authors.forename: E
authors.initials: E
authors.lastname: Menegaldo
authors.forename: G
authors.initials: G
authors.lastname: Jori
mesh_terms: D000818:Animals; D004337:Drug Carriers; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D054833:Isoindoles; D008077:Lipoproteins, LDL; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010778:Photochemotherapy; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017967:Zinc Compounds
chemical_list: D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D008077:Lipoproteins, LDL; D008081:Liposomes; D009942:Organometallic Compounds; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D015032:Zinc