title: The effect of intraocular gas and fluid volumes on intraocular pressure.
abstract: Large increases in the intraocular pressure (IOP) of postoperative gas-containing eyes may require the removal of gas or fluid to reduce the IOP to the normal range. Application of the ideal gas law to Friedenwald's equation provides a mathematical model of the relationship between IOP, intraocular gas and fluid volumes, and the coefficient of scleral rigidity. This mathematic model shows that removal of a given volume of gas or fluid produces an identical decrease in IOP and that the more gas an eye contains, the greater the volume reduction necessary to reduce the pressure. Application of the model shows that the effective coefficient of scleral rigidity is low (mean K, 0.0021) in eyes with elevated IOP that have undergone vitrectomy and retinal cryopexy and very low (mean K, 0.0013) in eyes with elevated IOP that have undergone placement of a scleral buckle and band. By using the appropriate mean coefficient of rigidity, the volume of material to be aspirated to produce a given decrease in IOP can be predicted with clinically useful accuracy.
authors.affiliation: Department of Ophthalmology, University of Kansas Medical Center, Kansas City 66103.
authors.forename: J N
authors.initials: JN
authors.lastname: Simone
authors.forename: M M
authors.initials: MM
authors.lastname: Whitacre
mesh_terms: D001274:Atmospheric Pressure; D001826:Body Fluids / Q000502:physiology*; D005740:Gases; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological; D012590:Sclera / Q000502:physiology; D012591:Scleral Buckling; D014786:Vision Disorders / Q000503:physiopathology
chemical_list: D005740:Gases