Interrelationship between the concentrations of some elements in the organs of Japanese with special reference to selenium-heavy metal relationships.
Multi-element analyses were conducted on internal organs (cerebrum, cerebellum, heart, spleen, liver and kidney) of Japanese obtained from 45 forensic medical autopsy cadavers. Elements analyzed and analytical methods were as follows: Ca, Cd, Cu, Fe, K, Mg, Na, P and Zn by inductively coupled plasma atomic emission spectrometry; total Hg (T-Hg) and inorganic Hg (I-Hg) by cold vapour atomic absorption spectrometry; methyl Hg (MeHg) by gas chromatography; and Se by fluorometry. A significantly positive correlation between Se and T-Hg was observed in kidney, liver, heart and spleen. The T-Hg/Se molar ratio was less than 1 in all the organs examined. The correlation between Zn and Cd was significant in liver and kidney. Multiple regression analyses using Se as a dependent and I-Hg, MeHg, Zn, Cd, Cu as independent variables were conducted on each organ. Inorganic Hg was a significant independent variable in kidney, whereas in liver and spleen it was MeHg. Cadmium was significant in explaining the variations in Se in liver and kidney medulla, indicating Cd-Se co-accumulation in humans.
Yoshinaga
J
J
Department of Human Ecology, School of Health Sciences, Faculty of Medicine, University of Tokyo, Japan.
Matsuo
N
N
Imai
H
H
Nakazawa
M
M
Suzuki
T
T
Morita
M
M
Akagi
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D002104:Cadmium / Q000032:analysis; D002849:Chromatography, Gas; D005260:Female; D005470:Fluorometry; D006801:Humans; D007564:Japan; D008297:Male; D008670:Metals / Q000032:analysis* / Q000493:pharmacokinetics; D008875:Middle Aged; D012044:Regression Analysis; D012643:Selenium / Q000032:analysis*; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution
D008670:Metals; D002104:Cadmium; D012643:Selenium