title: IgG1-4 subclasses in paraproteinemias.
abstract: The concentration of IgG1-4 subclasses was determined in a series of 10 IgG1 paraproteinemias (5 multiple myelomas and 5 non-myeloma paraproteinemias) and in a series of 11 IgA paraproteinemias (7 multiple myelomas and 4 non-myeloma paraproteinemias). In the group of IgG1 myelomas, deficiency was established in the subclasses IgG2-4, in the group of IgA myelomas, deficiency was proved in all IgG1-4 subclasses as compared with non-myeloma paraproteinemias. Decreased IgG heterogeneity in IgG1 myelomas was demonstrated by the method of isoelectric focusing.
authors.affiliation: 2nd Department of Medicine, Charles University, Hradec Králové, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Tichý
authors.forename: Z
authors.initials: Z
authors.lastname: Hrncír
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G