title: IgA nephritis associated with plasminogen abnormalities.
abstract: Two patients with IgA nephritis associated with hereditary plasminogen abnormalities are described. One patient had dysplasminogenemia and the other had plasminogen deficiency. In both patients, renal biopsy specimens showed significant arteriosclerotic changes in addition to mesangial proliferation. Increased fibrinopeptide A concentration in their plasma suggested increased thrombin generation. In one patient, no systemic arteriosclerosis coexisted, judging from normal optic fundi and the absence of neurological and cardiac abnormalities. In IgA nephritis, renal vascular hyalinosis is often observed, probably resulting from vascular injury. Thus, it was suggested that the decreased fibrinolysis and renal vascular injury of these patients synergistically induced more fibrin thrombi and accelerated arteriosclerosis of the kidney. These cases imply the important role of fibrinolytic disorders in the progression of IgA nephritis.
authors.affiliation: 3rd Department of Internal Medicine, Kumamoto University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamoto
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Sakata
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Kuwahara
authors.forename: S
authors.initials: S
authors.lastname: Arima
authors.forename: N
authors.initials: N
authors.lastname: Ikezaki
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Kiyama
authors.forename: M
authors.initials: M
authors.lastname: Tomita
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology; D001706:Biopsy; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications*; D001780:Blood Coagulation Tests; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000172:deficiency*
chemical_list: D010958:Plasminogen