Ketotifen prevents skin fibrosis in the tight skin mouse.
Mast cells in the skin of the tight-skin mouse show an enhanced degranulation compared to those of syngeneic litter mates. Oral treatment with ketotifen, an inhibitor of mast cell degranulation, at a dose comparable to that recommended for man, was associated with a decrease in both mast cell degranulation and in skin fibrosis, suggesting the potential for its use in human scleroderma.
Walker
M
M
Department of Medicine, Medical University of South Carolina, Charleston.
Harley
R
R
LeRoy
E C
EC
D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis; D007665:Ketotifen / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D012595:Scleroderma, Systemic / Q000188:drug therapy; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D007665:Ketotifen