A novel dibenzoxazepine derivative (BY-1949) increases regional cerebral blood flow.
The effects of BY-1949, a novel dibenzoxazepine derivative, on the regional cerebral blood flow were investigated in conscious cats. Oral administration of BY-1949 (10-50 mg/kg) significantly increased in a dose-related manner the regional cerebral blood flow in all brain regions examined. Vinpocetine (20 mg/kg p.p.) had similar effects that were shorter-lasted than those of BY-1949. From these results, it seems likely that amelioration by BY-1949 of cognitive impairment following cerebral ischemia/hypoxia or that occurs on ageing is at least partly explainable in terms of its effects on the cerebral circulation.
Sugawa
M
M
Department of Pharmacology, Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan.
Koide
T
T
Kohda
A
A
Takato
M
M
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003989:Dibenzoxazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D005260:Female; D008297:Male; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology
D003989:Dibenzoxazepines; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; C058844:3-methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate