title: A late receptor dystrophy in the Labrador retriever.
abstract: Dark adapted single flash and light adapted 30 Hz photopic flicker ERGs were recorded from a litter of seven Labrador Retrievers bred from parents affected with generalized progressive rod-cone dystrophy. After an initial increase of b-wave amplitudes from 5 weeks to 4 months similar to the controls, the b-wave amplitudes of the litter were significantly decreased (P less than 0.005) at 7 months. At 21 months the b-wave amplitudes were very low, although some response to 30 Hz photopic flicker was still left. The ERG changes indicated a late onset progressive rod-cone dystrophy which developed after maturation of the retina. The development of this photoreceptor dystrophy has not previously been described.
authors.affiliation: Department of Surgery, College of Veterinary Medicine, Töölö Hospital, Helsinki, Finland.
authors.forename: B
authors.initials: B
authors.lastname: Kommonen
authors.forename: U
authors.initials: U
authors.lastname: Karhunen
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D004596:Electroretinography; D005260:Female; D008297:Male; D010775:Photic Stimulation; D012162:Retinal Degeneration / Q000503:physiopathology / Q000662:veterinary*; D013997:Time Factors