title: Erythrocytes suppress calcitonin gene-related peptide- and vasoactive intestinal polypeptide-like immunoreactivities in cerebrovascular nerve fibers after subarachnoid hemorrhage.
abstract: Changes of calcitonin gene related-peptide (CGRP)- and vasoactive intestinal polypeptide (VIP)-like immunoreactivities (LI) in cerebrovascular nerve fibers on the dog basilar artery were immunohistochemically examined by using whole-mount preparations after single percutaneous injection of blood components into the cisterna magna. Blood components were prepared from autologous arterial blood. CGRP- and VIP-LI in cerebrovascular nerve fibers were highly suppressed after the injection of washed erythrocytes, but only moderately after the injection of platelet-rich or platelet-poor plasma. The results suggest that erythrocytes may suppress CGRP- and VIP-LI in cerebrovascular nerve fibers after subarachnoid hemorrhage.
authors.affiliation: Department of Anatomy (1st Division), Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nozaki
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Uemura
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000294:innervation*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000503:physiopathology; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide