title: An immunohistochemical study of dermatofibrosarcoma protuberans supports its fibroblastic character and contradicts neuroectodermal or histiocytic components.
abstract: Paraffin-embedded material from 26 cases of dermatofibrosarcoma protuberans (DFSP) was investigated by the peroxidase-antiperoxidase technique. Antibodies to S-100 protein, Leu-7 antigen, and neuron-specific enolase (neural markers); to lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin (histiocytic markers); and to cytokeratin, desmin, vimentin, and factor VIII were used. The tumor cells reacted only for vimentin. In addition, 12 cases showed positive reactions with histiocytic markers (1-3% of the cells; in two cases, up to 10%). These results support a fibroblastic and contradict a neural or histiocytic histogenesis of DFSP.
authors.affiliation: Clinic for Dermatology and Venerology, Medical University of Lübeck, F.R.G.
authors.forename: R
authors.initials: R
authors.lastname: Lautier
authors.forename: H H
authors.initials: HH
authors.lastname: Wolff
authors.forename: R E
authors.initials: RE
authors.lastname: Jones
mesh_terms: D005347:Fibroblasts / Q000473:pathology; D005354:Fibrosarcoma / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin