title: Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.
abstract: Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.
authors.affiliation: Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
authors.forename: G
authors.initials: G
authors.lastname: Conn
authors.forename: M L
authors.initials: ML
authors.lastname: Bayne
authors.forename: D D
authors.initials: DD
authors.lastname: Soderman
authors.forename: P W
authors.initials: PW
authors.lastname: Kwok
authors.forename: K A
authors.initials: KA
authors.lastname: Sullivan
authors.forename: T M
authors.initials: TM
authors.lastname: Palisi
authors.forename: D A
authors.initials: DA
authors.lastname: Hope
authors.forename: K A
authors.initials: KA
authors.lastname: Thomas
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004730:Endothelium, Vascular / Q000378:metabolism; D006023:Glycoproteins / Q000235:genetics* / Q000302:isolation & purification; D006133:Growth Substances / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D016133:Polymerase Chain Reaction; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D042461:Vascular Endothelial Growth Factor A
chemical_list: D006023:Glycoproteins; D006133:Growth Substances; D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D004247:DNA