The reaction of lymphatic component of hemopoiesis to fractionated irradiation and repeated bone marrow transplantation.
Mice were repeatedly subjected to individual doses of 60Co-gamma rays at intervals of four days up to total doses of 3, 6, 9, 12, 15, 18, 21 and 24 Gy. Under these conditions, signs of partial adaptation of the lymphatic component of hemopoiesis to conditions of repeated irradiations were found in mice which were given transplants of 10(6) nuclear cells of syngenetic bone marrow after each irradiation. Systematic findings of statistically significant differences in the values of the lymphatic hemopoietic component parameters studied between bone marrow recipients and animals subjected only to repeated irradiations were recorded after 24th day of experiment in mice which received total doses of 21 and 24 Gy. A positive influence of repeated transplantations in bone marrow recipients became manifested in these experimental groups already upon withdrawals made on day 4 after the last irradiation. A quite pronounced increase in the values of the bone marrow recipients' lymphatic hemopoietic component studied was then recorded upon withdrawals made on day 9 after the last irradiation.
Hofer
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Viklická
S
S
Tkadlecek
L
L
Karpfel
Z
Z
D000222:Adaptation, Physiological; D000818:Animals; D016026:Bone Marrow Transplantation; D006410:Hematopoiesis; D007958:Leukocyte Count; D008208:Lymphatic System / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology; D051379:Mice; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000503:physiopathology* / Q000628:therapy; D013154:Spleen / Q000502:physiology; D013950:Thymus Gland / Q000502:physiology; D013997:Time Factors