[The mechanisms of a decrease in the toxic action of cisplatin when administered jointly with preparation K-2-9 to mice with melanoma B16].
The K-2-9 preparation was determined to change cis-platinum pharmacokinetics, that resulted in its pharmacodynamics alterations. The higher Pt concentrations in the blood of animals which were given the K-2-9 preparation provided selectivity of cytostatic accumulation in the tumour tissue, that was accompanied by more prolonged inhibition of the DNA synthesis. A decrease in the toxicity of cis-platinum is associated with a change in the elimination pathway and acceleration of its removal from the organism.
Chekhun
V F
VF
Pel'kis
F P
FP
Serebriakova
E A
EA
Singin
A S
AS
Sokolova
I S
IS
Negreĭ
G Z
GZ
Kulik
G I
GI
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D002945:Cisplatin
O nekotorykh mekhanizmakh snizheniia toksicheskogo deĭstviia tsisplatina pri sovmestnom vvedenii s preparatom K-2-9 mysham s melanomoĭ B-16.