title: Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of gentamicin.
abstract: Administration of the aminoglycoside antibiotic, gentamicin, even at therapeutic doses, causes renal lysosomal phospholipidosis. We now report that protein- and lipid-bound sialic acid levels are increased significantly in a time-dependent fashion in the renal cortex of rats injected with gentamicin (10 mg/kg body wt. per day) for 4-10 days and a significant relationship could be observed between these two parameters. This elevation was not due to tissue regeneration, since it was not observed in cisplatin-treated animals.
authors.affiliation: Laboratoire de Chimie Physiologique, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: B K
authors.initials: BK
authors.lastname: Kishore
authors.forename: S
authors.initials: S
authors.lastname: Ibrahim
authors.forename: P M
authors.initials: PM
authors.lastname: Tulkens
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism; D019158:N-Acetylneuraminic Acid; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000378:metabolism*
chemical_list: D005839:Gentamicins; D010743:Phospholipids; D012794:Sialic Acids; D010758:Phosphorus; D019158:N-Acetylneuraminic Acid; D002945:Cisplatin