title: N-acetylation phenotyping with sulphadimidine in a Turkish population.
abstract: The distribution of acetylator phenotypes was studied in 244 unrelated Turkish subjects. Sulphadimidine and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples after an oral dose of 10 mg/kg. Subjects with 37.5% or less acetylsulphadimidine in plasma were regarded as slow acetylators and the others as rapid acetylators. The mean plasma concentration of acetylsulphadimidine was about 2.5-times lower in slow acetylators. Urinary excretion of total sulphadimidine (free + acetylated) was also significantly lower in slow acetylators compared to rapid acetylators. The frequency of slow acetylators was 60.7% in the population (95% confidence interval 54.3% to 66.8%). Sulphadimidine acetylation showed no variation due to sex, age, body weight or pre-existing disease.
authors.affiliation: Hacettepe University, School of Medicine, Department of Pharmacology, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
authors.forename: N E
authors.initials: NE
authors.lastname: Basci
authors.forename: S
authors.initials: S
authors.lastname: Kalan
authors.forename: M
authors.initials: M
authors.lastname: Tuncer
authors.forename: S O
authors.initials: SO
authors.lastname: Kayaalp
mesh_terms: D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013418:Sulfamethazine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D013997:Time Factors; D014421:Turkey
chemical_list: C032633:N-acetylsulfamethazine; D013418:Sulfamethazine