Antithrombin III levels in preeclampsia.
Antithrombin III (AT-III) activity was measured and compared in 29 patients with preeclampsia and 31 women with normal pregnancies. AT-III levels were 83 +/- 25% in preeclamptic patients with greater than 5 g/l proteinuria compared with 102 +/- 11% in the controls. Less severe proteinuria was not associated with decreased AT-III levels. Multivariate analysis revealed that the duration of pregnancy and the degree of proteinuria had an independent negative effect on AT-III levels. AT-III activity correlated poorly with platelet counts and blood pressure measurements. We conclude that urinary loss appears to be the major mechanisms of lower AT-III levels observed in our patients with preeclampsia.
Aghai
E
E
Institute of Hematology, Lady Davis Carmel Hospital, Haifa, Israel.
Brunstein
J
J
Quitt
M
M
Abramovici
H
H
Froom
P
P
D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology; D011507:Proteinuria / Q000097:blood / Q000503:physiopathology
D000990:Antithrombin III