Sequence of cardiorespiratory effects of soman altered by route of administration.
Dilute soman was administered to anesthetized guinea-pigs by slow infusion (30 micrograms/kg/10 min); intravenous (IV), subcutaneous (SC), intraperitoneal (IP), intratracheal (IT), and upper-airway (UAW) routes were used. Times to ventilatory failure were 8.8 +/- 1.3 min (IV), 10.5 +/- 1.2 min (I.T.), 17.3 +/- 2.8 min (IP), 34.8 +/- 5.1 min (UAW), and 36.0 +/- 4.4 min (SC) for the 5 routes of exposure. Atrioventricular (AV) block occurred before ventilatory failure with all routes of challenge except IT and IP; when it did occur, AV block typically began after one-half reduction in minute volume. The results reflect the effects of rate of absorption and noncritical-site binding of the organophosphorus compound when all routes are compared and suggest that the pathogenesis of intoxication in the anesthetized guinea-pig is different when soman is infused into regions heavily enervated by vagal afferents.
Franz
D R
DR
United States Army Medical Research, Institute of Chemical Defense, Aberdeen Proving Ground, MD.
Hilaski
R
R
D000281:Administration, Intranasal; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D006168:Guinea Pigs; D006327:Heart Block / Q000139:chemically induced; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007442:Intubation, Intratracheal; D008176:Lung Volume Measurements; D008297:Male; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012137:Respiratory System / Q000187:drug effects*; D012999:Soman / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*
D012999:Soman