Intraoperative radiation therapy and hyperthermia. Morbidity and mortality from this combined treatment modality for unresectable intra-abdominal carcinomas.
This is a report of a phase I trial of intraoperative radiation therapy in combination with intraoperative hyperthermia for the treatment of locally advanced, unresectable intra-abdominal carcinomas. Using an ultrasound transducer system specifically designed for intraoperative applications, 19 patients have been successfully treated, demonstrating the feasibility of this combination modality. The morbidity (58%) and mortality (11%) rates reported in this series are comparable to rates reported in series of similar patients receiving intraoperative radiation therapy alone. There is still a great need for considerable technological development to enable the use of intraoperative hyperthermia to treat large, complexly shaped intra-abdominal tumors, and phase II and III trials of this combination treatment modality should be performed.
Colacchio
T A
TA
Department of Surgery, Dartmouth Medical School, Hanover, NH 08755.
Coughlin
C
C
Taylor
J
J
Douple
E
E
Ryan
T
T
Crichlow
R W
RW
D000008:Abdominal Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy*; D002277:Carcinoma / Q000150:complications / Q000401:mortality / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects* / Q000379:methods; D007430:Intraoperative Care / Q000009:adverse effects* / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000401:mortality / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy; D011879:Radiotherapy Dosage; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000379:methods