Age-related changes of erythrocyte membrane in the senescence-accelerated mouse.
Age-related changes in erythrocytes in senescence-accelerated mice (SAM-P) and control mice with normal aging characteristics (SAM-R) were examined. A significant decrease in the number of erythrocytes and significant increases in MCV and ATP levels were observed with aging in SAM-P, while no significant changes were seen in SAM-R. Erythrocytes in aged SAM-P were less fragile than those in aged SAM-R. The contents of cholesterol and phospholipids in erythrocyte membranes increased significantly in aged SAM-P, but the molar ratio of cholesterol/phospholipid decreased. The plasma cholesterol level of SAM-P decreased with aging. Changes such as those observed in SAM-P were not seen in SAM-R during the period of observation.
Abe
H
H
Research Institute of Oriental Medicine, Kinki University, Osaka, Japan.
Orita
M
M
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000032:analysis / Q000502:physiology*; D008055:Lipids / Q000032:analysis / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D009996:Osmotic Fragility
D008055:Lipids