UW solution improves duration and quality of clinical liver preservation.
Prolonged liver preservation (up to 17 hours) with UW solution had no adverse effect on perioperative blood loss or results of postoperative serum biochemistry studies. After use of this solution, biliary and vascular complications as well as evidence of histologic damage were less. The advantages of the extended preservation time permit liver transplantation to be done as a semi-elective procedure; more patients can be waiting at home instead of near the transplant center. The availability of UW solution also makes it possible to send grafts long distances throughout the nation. Furthermore, surgeons can arrange for backup patients in case the recipient proves to be inoperable. This capability should reduce organ wastage, even before the time limits of preservation with UW solution have been determined definitely. We feel that UW solution undoubtedly has improved both the duration and quality of liver graft preservation.
Cooper
J
J
Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905.
Rettke
S R
SR
Ludwig
J
J
Ayalon
A
A
Sterioff
S
S
Wiesner
R H
RH
Krom
R A
RA
D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D005978:Glutathione; D006801:Humans; D006982:Hypertonic Solutions; D007328:Insulin; D016031:Liver Transplantation / Q000502:physiology; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011887:Raffinose; D012996:Solutions
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose