title: The role of Campylobacter (Helicobacter) pylori in disorders of the gastrointestinal tract.
abstract: To evaluate the role of Campylobacter pylori in different gastrointestinal disorders, serum IgG antibodies against C. pylori were determined in dyspeptic patients and in a control group of healthy children and adults. Twenty-eight percent of the dyspeptic patients with normal mucosa were seropositive. Among the patients with altered mucosa, the seroprevalence increased from duodenitis (48%) to gastritis (89%) and gastric or duodenal ulcer, gastric stump gastritis and carcinoma (100%, for each group, respectively). The C. pylori detection rate was lowest in patients with duodenitis alone (19%) and highest in patients with duodenal ulcers (95%). Therefore, C. pylori does not play an important role in patients with duodenitis alone. About 30% of patients with gastritis, active duodenal or gastric ulcer had antibody levels as low as the seroconverted dyspeptic patients but with normal gastroduodenal mucosa. C. pylori was not considered a causative factor for mucosal damage in these patients.
authors.affiliation: Max von Pettenkofer-Institut, München, FR Germany.
authors.forename: B
authors.initials: B
authors.lastname: Przyklenk
authors.forename: A
authors.initials: A
authors.lastname: Bauernfeind
authors.forename: W
authors.initials: W
authors.lastname: Bornschein
authors.forename: G
authors.initials: G
authors.lastname: Emminger
authors.forename: K
authors.initials: K
authors.lastname: Heilmann
authors.forename: S
authors.initials: S
authors.lastname: Schweighart
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis; D002167:Campylobacter / Q000276:immunology / Q000472:pathogenicity*; D002648:Child; D002675:Child, Preschool; D004415:Dyspepsia / Q000276:immunology / Q000382:microbiology; D004724:Endoscopy; D005260:Female; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G