Orbital recurrence of retinoblastoma successfully treated by combined therapy.
Five children with an orbital recurrence of retinoblastoma have been successfully treated by a combination of excision biopsy of the tumour mass, radical orbital radiotherapy, and systemic chemotherapy. Nine previous children, consecutive with the five presented here, died from disseminated retinoblastoma after failure of earlier treatment programmes for orbital recurrence. An aggressive therapeutic approach is justified by this improvement in survival.
Goble
R R
RR
Department of Ophthalmology, St Bartholomew's Hospital, London.
McKenzie
J
J
Kingston
J E
JE
Plowman
P N
PN
Hungerford
J L
JL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D005134:Eye Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D012175:Retinoblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery