title: [Neonatal Pepper's syndrome. Apropos of a series of 22 cases].
abstract: From 1960 to 1987, 22 neonates were treated at the Institut Gustave-Roussy for a Pepper' syndrome. During this period of time, 83 children were treated for the same syndrome, the neonatal type representing 26% of cases. Twelve of the 22 neonates presented with the rapidly evolving type, requiring an immediate aggressive treatment. In 4 of them death occurred early despite treatment. The 10 other neonates presented with a slowly progressive disease. In 5 of them treatment of the metastatic disease was not necessary to obtain remission. The survival rate of disease without relapses in 77%, with a median follow-up of 8 years. So, despite the high incidence of rapidly progressive forms, the prognosis of this disease remains favorable in neonates, provided an accurate treatment initiated early.
authors.affiliation: Département de Pédiatrie, Institut Gustave-Roussy, Villejuif.
authors.forename: C
authors.initials: C
authors.lastname: Labreveux de Cervens
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: D
authors.initials: D
authors.lastname: Valteau
authors.forename: L
authors.initials: L
authors.lastname: Brugières
authors.forename: T
authors.initials: T
authors.lastname: de Cervens
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: C
authors.initials: C
authors.lastname: Patte
authors.forename: F
authors.initials: F
authors.lastname: Flamant
authors.forename: J
authors.initials: J
authors.lastname: Lemerle
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D009447:Neuroblastoma / Q000556:secondary* / Q000628:therapy; D011379:Prognosis; D013577:Syndrome; D013899:Thoracic Neoplasms
vernacular_title: Syndrome de Pepper néonatal. A propos d'une série de 22 cas.