title: Gallstone dissolution in vitro using methyl tert-butyl ether: radiologic selection criteria.
abstract: Methyl tert-butyl ether dissolves cholesterol gallbladder stones when infused through a percutaneous transhepatic catheter. All gallstones, however, contain noncholesterol components that are insoluble in lipid solvents and may be too large to be aspirated through a small catheter or flushed from the gallbladder. To identify which patients have gallstones that are most likely to completely dissolve, we evaluated the ability of methyl tert-butyl ether to dissolve gallstones in vitro based on their radiodensity and size. Radiodensity influenced completeness of dissolution (p less than 0.01), but size did not (p greater than 0.5). Twenty-six of 32 radiolucent stones (81%) dissolved completely, leaving residual debris less than 2 mm in diameter. Only 2 of 32 radiopaque stones (6%) dissolved completely. Insoluble radiolucent and radiopaque stones less than 0.5 cm in diameter were black pigment stones. Four radiolucent and 19 of 22 radiopaque stones (86%) greater than 0.5 cm in diameter underwent partial dissolution leaving residual debris 2 mm or larger. By infrared spectroscopy, calcium bilirubinate and calcium carbonate were identified as the principal components of this methyl tert-butyl ether-insoluble debris. Until methods for dissolving or fragmenting noncholesterol components of gallstones are available, only patients with radiolucent gallstones should be treated with methyl tert-butyl ether.
authors.affiliation: Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota.
authors.forename: P E
authors.initials: PE
authors.lastname: Nelson
authors.forename: T P
authors.initials: TP
authors.lastname: Moyer
authors.forename: J L
authors.initials: JL
authors.lastname: Thistle
mesh_terms: D002769:Cholelithiasis / Q000032:analysis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004987:Ethers / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D008738:Methyl Ethers; D011859:Radiography; D012995:Solubility; D012997:Solvents / Q000627:therapeutic use*; D013055:Spectrophotometry, Infrared
chemical_list: D004987:Ethers; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether