title: Management of multiple cholesterol embolization syndrome--a case report.
abstract: A sixty-two-year-old man who underwent coronary angiography and received acute thrombolytic and anticoagulant therapy for acute myocardial infarction developed multisystemic injury, including renal insufficiency and cutaneous manifestations. Fundoscopic examination and skin biopsy specimen led to the diagnosis of multiple cholesterol embolization syndrome (MCES). Discontinuation of anticoagulants and administration of hemostatic (carbazochrome, tranexamic acid, reptilase, and vitamin K) and antihyperlipidemic (cholestyramine and probucol) drugs resulted in temporary improvement of cutaneous and renal disorders and extended survival for about one year. Besides severe aortic atherosclerosis, postmortem examination revealed numerous cholesterol emboli to multiple organs. MCES is a rare but serious complication of left heart catheterization and anticoagulant therapy, and the optimal treatment remains to be established. The authors suggest here that the above-mentioned therapy might be effective for management of MCES.
authors.affiliation: Department of Cardiology, Otsu Red Cross Hospital, Shiga, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Tomioka
authors.forename: K
authors.initials: K
authors.lastname: Doyama
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: K
authors.initials: K
authors.lastname: Kosuga
authors.forename: T
authors.initials: T
authors.lastname: Saiga
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D006328:Cardiac Catheterization / Q000009:adverse effects*; D002784:Cholesterol; D004617:Embolism / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000628:therapy; D012871:Skin Diseases / Q000209:etiology / Q000628:therapy*; D013577:Syndrome
chemical_list: D000925:Anticoagulants; D002784:Cholesterol