Potential distribution across a plasma protein-coated poly(L-lactide) microcapsule surface.
A model is presented for the potential distribution across a protein-coated microcapsule membrane. The adsorbed protein layer is assumed to be divided into three sub-layers. The outer sub-layer is rich in positive fixed charges and the medium sub-layer in negative fixed charges, while the inner sub-layer may be either charged or uncharged. Also, the microcapsule membrane is negatively charged. The ionic partition coefficients into the inner sub-layer are less than unity, while those into the other sub-layers are unity. This model explains well the accelerated degradation of poly(L-lactide) microcapsules with an adsorbed protein layer onto their surface (Makino et al., 1987 c).
Makino
K
K
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Ohshima
H
H
Kondo
T
T
D001798:Blood Proteins; D002214:Capsules; D007773:Lactates; D019344:Lactic Acid; D008564:Membrane Potentials; D008567:Membranes, Artificial; D008962:Models, Theoretical; D011091:Polyesters; D011108:Polymers
D001798:Blood Proteins; D002214:Capsules; D007773:Lactates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)