[Effect of propiverine hydrochloride on the function of the bladder in decerebrated dogs].
The effect of propiverine hydrochloride (P-4) on the function of the bladder in decerebrated dogs was compared with that of propantheline, an anticholinergic drug which is used for the treatment of micturitional disorders. P-4 (5 and 10 mg/kg, i.v.) significantly increased maximum vesical volume (Vmax); and at the dose of 10 mg/kg, i.v., it also significantly increased effective vesical volume (EV) when determined by cystometry. However, at the dose level of 2, 5 and 10 mg/kg, i.v., P-4 had no effect on residual volume (RV) after micturition contraction. Propantheline (0.25 and 0.5 mg/kg, i.v.) also significantly increased Vmax, but showed no effect on EV. At doses higher than 0.016 mg/kg, i.v., propantheline significantly increased RV. These findings indicate that P-4 is a useful drug for the treatment of pollakiuria.
Kaneko
S
S
Biol. Res. Lab. Taiho Pharm. Co., Ltd., Tokushima, Japan.
Kitazato
K
K
Yamazaki
Y
Y
Okada
H
H
Nagai
M
M
Iriki
M
M
D001561:Benzilates / Q000494:pharmacology* / Q000627:therapeutic use; D003655:Decerebrate State; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology* / Q000627:therapeutic use; D011413:Propantheline / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects*; D014555:Urination Disorders / Q000188:drug therapy
D001561:Benzilates; D010276:Parasympatholytics; D011413:Propantheline; C015586:propiverine