Deafferentation in the rat increases mechanical nociceptive threshold in the innervated limbs.
In this study in the rat, we evaluated the effect of unilateral, multiple cervical dorsal rhizotomy (C5-T1) on nociceptive thresholds in the unoperated limbs. This was tested by measuring the vocalization threshold to paw pressure. We report that deafferentation by dorsal rhizotomy results in a delayed, but transient increase in mechanical nociceptive thresholds in the 3 innervated limbs.
Kayser
V
V
Unité de Recherche en Physiopharmacologie du Système nerveux U. 161, INSERM, Paris, France.
Basbaum
A I
AI
Guilbaud
G
G
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005121:Extremities / Q000294:innervation*; D008297:Male; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds