Microphthalmia with single central incisor and hypopituitarism.
A patient is described with a new association of microphthalmia, single central incisor, and hypopituitarism believed to represent a holoprosencephaly malformation. In view of the genetic ramifications of this malformation and its variable manifestations, we would like to alert the clinician to consider holoprosencephaly whenever midline malformations are detected.
Artman
H G
HG
Department of Pediatrics, University of Nevada School of Medicine, Reno 89557.
Boyden
E
E
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D007180:Incisor / Q000002:abnormalities*; D008850:Microphthalmos / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed