title: Validation of a system for measurement of metabolic gas exchange during anaesthesia with controlled ventilation in an oxygen consuming lung model.
abstract: An oxygen consuming lung model was used for evaluation and validation of a technique for metabolic gas exchange measurements during controlled ventilation. The technique comprised a Servo 900 C ventilator (Siemens) and separate oxygen and carbon dioxide analysers (Beckman). Measurements of oxygen consumption and carbon dioxide production were made either by measuring inspired and expired ventilation and gas fractions in these volumes or by measuring gas fractions and calculating expired ventilation from inspired by transformation (Haldane). Irrespective of the FIO2, measured values correlated well with lung model settings: measured values were within +/- 2% of simulated. When Haldane transformation was used with an FIO2 of 0.5 there was a significant underestimation of oxygen consumption. Carbon dioxide production values correlated well irrespective of the FIO2 used or method of measurement of ventilation volume. Metabolic gas exchange measurements by measuring both inspired and expired ventilation volumes may be used when inert gases are not in equilibrium, for example during nitrous oxide anaesthesia.
authors.affiliation: Department of Anaesthesia and Intensive Care, Sahlgren's Hospital, University of Göteborg, Sweden.
authors.forename: K L
authors.initials: KL
authors.lastname: Svensson
authors.forename: H G
authors.initials: HG
authors.lastname: Sonander
authors.forename: O
authors.initials: O
authors.lastname: Stenqvist
mesh_terms: D000758:Anesthesia; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D010101:Oxygen Consumption / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012121:Respiration, Artificial