Chromosome abnormalities involving heterochromatic regions in monocytic leukemia.
We report two cases of monocytic leukemia associated with cytogenetic changes involving the juxtacentromeric heterochromatin of different chromosomes. In a patient with chronic myelomonocytic leukemia (CMMoL) we describe a translocation t(1;9)(q12;q13) in which the duplicated derivative chromosome 9q + showed a huge centromeric C-band, derived by fusion of the heterochromatic regions of chromosomes 1 and 9. The constitutional karyotype showed two heterochromatin polymorphisms, 1qh + and inv(9qh). In the second case, an acute monoblastic leukemia was associated with an abnormally elongated juxtacentromeric heterochromatic region of chromosome 4 that was not constitutionally present.
Rege-Cambrin
G
G
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Kerim
S
S
Scaravaglio
P
P
Michaux
J L
JL
Van den Berghe
H
H
Saglio
G
G
D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D006570:Heterochromatin; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D006570:Heterochromatin