Increased glucose use in the hypoglossal nucleus after hypoglossal nerve transection in aged rats.
We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-month-old rats. We also found a twofold increase in the difference between glucose uptake on the side of nerve transection compared to the control side in old rats.
Singer
P A
PA
Research Service, Kansas City Veterans Affairs Medical Center, Missouri 64128.
Mehler
S
S
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000502:physiology; D003714:Denervation; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D007839:Functional Laterality; D007002:Hypoglossal Nerve / Q000502:physiology* / Q000601:surgery; D008526:Medulla Oblongata / Q000378:metabolism*; D009416:Nerve Regeneration; D051381:Rats; D011916:Rats, Inbred F344
D003837:Deoxy Sugars; D003847:Deoxyglucose