title: Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia.
abstract: A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally.
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Gainesville.
authors.forename: K M
authors.initials: KM
authors.lastname: Heilman
authors.forename: D
authors.initials: D
authors.lastname: Bowers
authors.forename: R T
authors.initials: RT
authors.lastname: Watson
authors.forename: A
authors.initials: A
authors.lastname: Day
authors.forename: E
authors.initials: E
authors.lastname: Valenstein
authors.forename: E
authors.initials: E
authors.lastname: Hammond
authors.forename: R
authors.initials: R
authors.lastname: Duara
mesh_terms: D000328:Adult; D000647:Amnesia / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000503:physiopathology; D001931:Brain Mapping; D003337:Corpus Callosum / Q000098:blood supply*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D009949:Orientation / Q000502:physiology*; D011183:Postoperative Complications / Q000503:physiopathology*; D013788:Thalamus / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014888:Wechsler Scales
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose