title: A model for alcohol-enhanced permeation through polydimethylsiloxane membranes.
abstract: In this study the influence of paraben concentration on flux from solution in 1-propanol through polydimethylsiloxane membranes was investigated. Alcohol was sorbed by the polymer membrane leading to changes in membrane dimensions and increased membrane capacity to contain paraben (partition coefficient). Diffusion coefficients were not significantly influenced by alcohol sorption. Flux was increased 5-30 fold over nonimbibed donors such as water and polyols. An increase in paraben concentration reduced alcohol activity, its uptake by the membrane, and consequently the partition coefficient of paraben. As a result, flux increased with paraben concentration, reached a peak, and then declined. Maximal membrane concentration involves a trade-off between alcohol-membrane interaction (solvent activity) and paraben concentration, and occurred at paraben concentrations in the range of 1.3 to 1.4 mmol/g. At equimolar concentrations, flux was highest for methylparaben and declined as the series was ascended. Differences in flux between parabens at a specified molar concentration were due only to differences in diffusivity.
authors.affiliation: Rutgers University College of Pharmacy, Piscataway, NJ 08854.
authors.forename: J N
authors.initials: JN
authors.lastname: Twist
authors.forename: J L
authors.initials: JL
authors.lastname: Zatz
mesh_terms: D000433:1-Propanol / Q000032:analysis*; D000042:Absorption; D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D008956:Models, Chemical; D010226:Parabens / Q000032:analysis; D012995:Solubility; D013816:Thermodynamics
chemical_list: D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D010226:Parabens; D000433:1-Propanol