title: Pharmaco-toxicological effects of acetaminophen in rodents. Battery of tests to screen potential analgesic acetaminophen derivatives.
abstract: The pharmacological effects of acute oral administration of acetaminophen have been extensively evaluated in rodents. Using this drug as reference compound we have also standardized several pharmaco-toxociological tests in order to select new analgesic-antipyretic acetaminophen derivatives. According to the results obtained in this work, the following battery of assays is proposed to screen these compounds: a) pharmacological: antipyretic activity against Brewer's yeast-induced pyresis in rats; analgesic activity against chemical-induced writhings in mice and paw pressure test in rats; b) toxicological: oral acute toxicity in mice with and without phenobarbital pretreatment; determination of SGOT and SGPT activities as well as total bilirubin in mice. The usefulness of this procedure in the evaluation of drug effects is also considered.
authors.affiliation: Research Center, Department of Pharmacology, Sant Feliu de Llobregat, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Guasch
authors.forename: M
authors.initials: M
authors.lastname: Grau
authors.forename: J L
authors.initials: JL
authors.lastname: Montero
authors.forename: A
authors.initials: A
authors.lastname: Felipe
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001219:Aspartate Aminotransferases / Q000097:blood; D016227:Benzoquinones; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D011809:Quinones; D051381:Rats; D011919:Rats, Inbred Strains; D012835:Silver Nitrate
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D011809:Quinones; D000082:Acetaminophen; C029322:phenylbenzoquinone; D012835:Silver Nitrate; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase