title: Plasma and tissue vitamin E concentrations in sheep after administration of a single intraperitoneal dose of dl-alpha-tocopherol.
abstract: Blood plasma and tissue Vitamin E concentrations were determined in 20 sheep following a single i.p. dose of 5 g of dl-alpha-tocopherol. In addition, five sheep were used as controls (no treatment and killed at d 0). From the 20 vitamin E-dosed sheep, 4 were slaughtered on d 3, 6, 10, 15 and 28 after dosing. There was a significant time effect in alpha-tocopherol concentrations in all tissues. In most tissues, the peak alpha-tocopherol concentration was at 3 d postdosing. Uptake varied among the different tissues examined. Three days postdosing, a large uptake of vitamin E by the liver was observed; this supports the concept that hepatic tissues are a target organ for vitamin E action. Also at 3 d uptake was pronounced in spleen and lung. Vitamin E concentrations in the other body tissues at d 3 postdosing increased considerably, but to a lesser degree than those in liver, spleen and lung. Vitamin E concentration in all tissues declined 3 d after i.p. dosing.
authors.affiliation: Dept. of Anim. Sci., University of Florida, Gainesville 32601.
authors.forename: N
authors.initials: N
authors.lastname: Hidiroglou
authors.forename: G
authors.initials: G
authors.lastname: Butler
authors.forename: L R
authors.initials: LR
authors.lastname: McDowell
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D007274:Injections, Intraperitoneal / Q000662:veterinary; D008099:Liver / Q000378:metabolism; D008297:Male; D012756:Sheep / Q000097:blood / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution; D014810:Vitamin E / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014810:Vitamin E