Interactive inhibition of erythroid 59Fe utilization by benzene metabolites in female mice.
Using radioiron uptake into erythrocytes as a measure of hematopoiesis, it was demonstrated that benzene inhibited bone marrow function in female mice. Hydroquinone was marginally effective, but the inhibition occurred only at the highest dose tested (100 mg/kg). The combination of phenol and hydroquinone was more effective in reducing erythrocyte production than either chemical given alone. Catechol given alone was not inhibitory but when phenol was added to catechol, erythropoiesis was suppressed, as observed for the phenol and hydroquinone combination. It appears that benzene toxicity may be the result of cooperative inhibitory effects produced by its metabolites.
Guy
R L
RL
Joint Graduate Program in Toxicology, Rutgers, State University of New Jersey, Piscataway 08855-0789.
Dimitriadis
E A
EA
Hu
P D
PD
Cooper
K R
KR
Snyder
R
R
D000818:Animals; D001554:Benzene / Q000494:pharmacology*; D002396:Catechols / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006873:Hydroquinones / Q000494:pharmacology*; D007501:Iron / Q000097:blood*; D007504:Iron Radioisotopes; D008297:Male; D051379:Mice; D019800:Phenol; D010636:Phenols / Q000494:pharmacology*; D012016:Reference Values
D002396:Catechols; D006454:Hemoglobins; D006873:Hydroquinones; D007504:Iron Radioisotopes; D010636:Phenols; D019800:Phenol; D007501:Iron; D001554:Benzene; C034221:catechol; C031927:hydroquinone