Comparison of fluconazole with amphotericin B in treatment of histoplasmosis in normal and immunosuppressed mice.
The activities of fluconazole and amphotericin B against Histoplasma capsulatum were investigated. The minimum inhibitory concentrations ranged from 0.12 to 0.47 microgram/mL for amphotericin B and from 16 to 250 micrograms/mL for fluconazole. Fluconazole given orally twice a day for 6 consecutive days compared favorably with amphotericin B given intraperitoneally once every other day for a total of six doses in the treatment of histoplasmosis in normal and leukopenic mice.
Kobayashi
G S
GS
Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110.
Travis
S J
SJ
Medoff
G
G
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006660:Histoplasmosis / Q000188:drug therapy*; D007165:Immunosuppression Therapy; D007274:Injections, Intraperitoneal; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL
D000666:Amphotericin B; D015725:Fluconazole