[Effect of the destruction and activation of the caudate nuclei on the convulsive action of corazol kindling].
Chronic experiments on the rats have shown that the pharmacological destruction of caudate nuclei significantly elevates the general brain excitation and induces rapid development of the corazol kindling. The hippocampal destruction exerts an opposite effect. Regression analysis of this processes has shown that mechanism of the general brain excitation and those of epileptogenesis are different on the stage of the developing kindling. Caudate nucleus activation induces powerful inhibition of kindling behavioral convulsive reactions and its electrographic epileptic activity. These data suggest that the caudate nucleus is a significant structure of the antiepileptic brain system and confirm G. N. Kryzhanovsky's concept about the system-antisystem interrelationship in case of neuropathologic syndromes as a result of the system hyperactivity.
Makul'kin
R F
RF
Novitskiĭ
S A
SA
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000503:physiopathology; D003292:Convulsants / Q000009:adverse effects*; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D010433:Pentylenetetrazole / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D003292:Convulsants; D010433:Pentylenetetrazole
Vliianie razrusheniia i aktivatsii khvostatykh iader na sudorozhnye éffekty korazolovogo kindlinga.