Changes in coagulative and fibrinolytic activities in Triton WR-1339-induced hyperlipidemia in rats.
Changes in coagulative and fibrinolytic activities were studied in rats with hyperlipidemia induced by Triton WR-1339 (T-WR). After intravenous injection of T-WR (150, 200 or 300 mg/kg) into S.D. rats, dose-related increases in plasma lipids (total cholesterol, triglyceride, free cholesterol and phospholipid) were observed. In hyperlipidemic rats that received 300 mg/kg of T-WR, decreases in red blood cell count and Hb value were found. Significant increases in the ma value of the thromboelastogram and the fibrinogen level were observed in these T-WR treated rats. The alpha 2-plasmin inhibitor activity was found to decrease dose-relatedly. These results indicate that T-WR induced hyperlipidemia in rats is accompanied with an increase in coagulative activity and an indirect enhancement of fibrinolytic activity.
Okazaki
M
M
Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan.
Suzuki
M
M
Oguchi
K
K
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D005176:Factor XIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced; D008055:Lipids / Q000097:blood; D008297:Male; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000378:metabolism; D011092:Polyethylene Glycols; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D008055:Lipids; D000979:alpha-2-Antiplasmin; D011092:Polyethylene Glycols; D000990:Antithrombin III; D005340:Fibrinogen; D010958:Plasminogen; D005176:Factor XIII; D002784:Cholesterol; C016811:tyloxapol