title: Influence of jejunal hypertonic glucose infusion on sham-feeding-stimulated gastric acid secretion: evidence of a defective mechanism in duodenal ulcer patients.
abstract: The aims of the present study were to determine in 14 healthy subjects and 14 duodenal ulcer patients the reproducibility of the acid secretory response to a modified sham-feeding test and the effect on this response of intrajejunal hypertonic glucose instillation, in order to evaluate the possibility of the existence of a defective inhibition of the cephalic phase of gastric acid secretion in duodenal ulcer disease. The reproducibility of the acid secretory response to a modified sham-feeding test was demonstrated in both groups in two consecutive tests. The hypertonic glucose instillation produced a significant inhibition of the acid secretory response to modified sham feeding only in the healthy subjects, suggesting that duodenal ulcer patients may have a defective mechanism of acid inhibition during vagal stimulation by modified sham feeding. Non-significant changes were observed in plasma gastrin and pancreatic glucagon levels.
authors.affiliation: Pirovano Hospital, Buenos Aires, Argentina.
authors.forename: C A
authors.initials: CA
authors.lastname: Linares
authors.forename: J M
authors.initials: JM
authors.lastname: Carosella
authors.forename: A
authors.initials: A
authors.lastname: Banchero
authors.forename: A
authors.initials: A
authors.lastname: Correa
authors.forename: A B
authors.initials: AB
authors.lastname: Merlo
authors.forename: E
authors.initials: E
authors.lastname: Gomez
authors.forename: C A
authors.initials: CA
authors.lastname: Falasca
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005260:Female; D005526:Food, Formulated; D005744:Gastric Acid / Q000378:metabolism*; D005950:Glucose Solution, Hypertonic; D006801:Humans; D007322:Instillation, Drug; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D005950:Glucose Solution, Hypertonic