Accumulation of cardiac lipofuscin in mammals: correlation between sexual maturation and the first appearance of lipofuscin.
Accumulation of lipofuscin is an important phenomenon of the cellular aging process. The first appearance of cardiac lipofuscin showed a good correlation with sexual maturation, which was correlated with maximum life-span of mammals. Large metabolic changes occurred at sexual maturation. From these results, it is suggested that sexual maturation of mammals is the initiation period of the aging process. Correlation between sexual maturation and longevity was re-evaluated using many mammals. Domestic and laboratory animals showed an earlier sexual maturation than other mammals, including rodents.
Nakano
M
M
Institute for Medical Science of Aging, Aichi Medical University, Japan.
Mizuno
T
T
Gotoh
S
S
D000375:Aging / Q000502:physiology*; D000818:Animals; D002470:Cell Survival / Q000502:physiology; D005260:Female; D006321:Heart / Q000502:physiology*; D066298:In Vitro Techniques; D008062:Lipofuscin / Q000502:physiology*; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D009206:Myocardium / Q000166:cytology; D010860:Pigments, Biological / Q000502:physiology*; D011817:Rabbits; D012741:Sexual Maturation / Q000502:physiology*; D013997:Time Factors
D008062:Lipofuscin; D010860:Pigments, Biological