title: [Hereditary protein C deficiency and portal vein thrombosis].
abstract: Inherited defects of the natural coagulation inhibitors predispose patients to thrombosis. These disorders have similar clinical presentations with a strong family of thrombosis, episodes of recurrent venous thromboembolism, beginning in early adulthood. We report a case of upper gastrointestinal bleeding in a patient with portal hypertension due to portal-vein thrombosis secondary to hereditary protein C deficiency, an association that has seldom been reported. We conclude that protein C deficiency should be investigated in thrombotic states, namely after more frequent causes have been excluded.
authors.affiliation: Serviço de Medicina 4, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.
authors.forename: J N
authors.initials: JN
authors.lastname: dos Santos
authors.forename: A
authors.initials: A
authors.lastname: Mello e Silva
authors.forename: P
authors.initials: P
authors.lastname: Alexandrino
authors.forename: T
authors.initials: T
authors.lastname: Saldanha
authors.forename: M O
authors.initials: MO
authors.lastname: Carreira
authors.forename: E
authors.initials: E
authors.lastname: Ferreira
authors.forename: F
authors.initials: F
authors.lastname: de Pádua
mesh_terms: D005190:Family; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D020151:Protein C Deficiency; D012008:Recurrence; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics
vernacular_title: Deficiência hereditária de proteína C e trombose da veia porta.