Developmental increases in the inwardly-rectifying K+ current of embryonic chick ventricular myocytes.
Whole-cell and single-channel inwardly-rectifying K+ currents (IK1) of early (3-day-old) and late (17-day-old) embryonic chick ventricular myocytes were compared to ascertain whether there are developmental changes in the properties of this conductance. The magnitude of the IK1 conductance in the early myocytes was small, but it was increased about five-fold in the older embryonic myocytes. It was found that the density of inwardly-rectifying K+ channels was greater (in the surface membrane) of the 17-day than in the 3-day embryonic myocyte. In addition, the single channel conductance for 17-day myocytes was several-fold larger than for the 3-day myocytes. These results suggest that cardiac inward rectifier channels may not only proliferate in number, but may also undergo structural alterations during development.
Josephson
I R
IR
Department of Physiology and Biophysics, University of Cincinnati, College of Medicine, OH 45267-0576.
Sperelakis
N
N
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004553:Electric Conductivity; D005318:Fetal Heart / Q000502:physiology*; D008564:Membrane Potentials; D015221:Potassium Channels / Q000502:physiology*; D016276:Ventricular Function
D015221:Potassium Channels