A proposal of indices to describe the carcinoembryonic antigen time course in in order to assess the effects of treating recurrent colo-rectal carcinoma.
In order to assess the effects of treating recurrent or non-resectable colo-rectal cancer, the following 5 indices for the serum CEA time course were devised: 1. If the serum CEA doubling time is altered by any treatment from D1 to D2 we term D2/D1 as the "CEA doubling time ratio" of the treatment; 2. the per cent decrease in the serum CEA level from CEA1 to CEA2 is calculated by (logCEA1 - logCEA2) X 100/logCEA1; 3. the period when the CEA level has returned to normal after a treatment is termed the "normalization period"; 4. "backward time retrieval" is the period between the lowest point of the posttreatment CEA and the crossing-point of this level by the pretreatment rising slope and; 5. "forward time earning" can also be defined. By using these indices, surgical treatments resulted in a higher per cent decrease in CEA, a longer normalization period but a shorter doubling time when the tumor recurred.
Iwama
T
T
Research Center for Polyposis and Intestinal Disease, Tokyo Medical and Dental University, Japan.
Mishima
Y
Y
Sato
H
H
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002272:Carcinoembryonic Antigen