Fatty acid control of growth of human cervical and endometrial cancer cells.
Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.
Gleeson
R P
RP
Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.
Ayub
M
M
Wright
J T
JT
Wood
C B
CB
Habib
N A
NA
Soutter
W P
WP
Sullivan
M H
MH
White
J O
JO
D002455:Cell Division / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D013229:Stearic Acids / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology*
D013229:Stearic Acids; D004815:Epidermal Growth Factor