An epidemiological study of contact allergy to 5-chloro-3-methyl isothiazolone/3-methyl isothiazolone in Strasbourg.
In Strasbourg, the incidence of allergy to the mixture of 5-chloro-3-methyl isothiazolone and 3-methyl isothiazolone (MCI) in 540 patients (313 women and 227 men), routinely tested with this preservative as part of the standard series of allergens, was 1.11%. The frequency was 1.6% in women and 0.44% in men. A total of 6 cases of allergy, 5 in women and 1 in a man, to MCI were detected. In 5 cases out of 6, the patient was shown to have used cosmetic products containing this preservative. Finally, in 5 cases out of 6, the subjects allergic to MCI also tested positively for nickel, while only 15% of the total of 540 subjects tested with MCI had a nickel allergy confirmed by patch tests.
Foussereau
J
J
Clinique Dermatologique, Hôpital Civil, Strasbourg, France.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003358:Cosmetics / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests / Q000379:methods; D012737:Sex Factors; D013844:Thiazoles / Q000009:adverse effects*
D003358:Cosmetics; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; D009532:Nickel; C011421:5-chloro-2-methyl-4-isothiazolin-3-one