HLA-A, B, C and DR antigens in nickel contact sensitivity.
The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P less than 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.
Mozzanica
N
N
Department of Dermatology, University of Milan, Italy.
Rizzolo
L
L
Veneroni
G
G
Diotti
R
R
Hepeisen
S
S
Finzi
A F
AF
D000293:Adolescent; D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015808:HLA-DR6 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D012306:Risk
D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D015808:HLA-DR6 Antigen; D009532:Nickel