Antiischemic effects of alinidine in paced isolated rat hearts.
Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminished while lactate accumulated. Infusion of alinidine into the perfusate at low-flow conditions, resulted in a mean concentration of 15.0 +/- 0.60 microM, and prevented the mechanical and biochemical changes of low-flow perfusion, thus indicating maintenance of aerobic metabolism under hypoxic conditions. These heart rate-independent cardioprotective effects of the "specific bradycardic" drug alinidine are discussed in light of the adenosine antagonistic actions of this compound which should prevent coronary steal.
Streller
I
I
Department of Pharmacology, Boehringer Ingelheim KG, FRG.
Walland
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002304:Cardiac Pacing, Artificial; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D004734:Energy Metabolism / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats
D007773:Lactates; D010725:Phosphocreatine; D019344:Lactic Acid; D000255:Adenosine Triphosphate; C022192:alinidine; D003000:Clonidine