Intralesional cis-diamminedichloroplatinum and purified collagen treatment of human metastatic malignancies: a feasibility study.
A feasibility study of the treatment of advanced superficial human malignant tumors utilizing direct intralesional injections of cisplatin mixed with purified bovine collagen was performed. The purpose of using intralesional injection of cisplatin mixed with collagen was to limit the drug exposure to normal tissues while increasing the dose and duration of exposure to the tumor. Fourteen evaluable superficial tumors in four patients (melanoma, breast CA, squamous CA from larynx) received a total of 65 treatments in the outpatient clinic setting. All patients had failed prior treatment with systemic intravenous cisplatin. Lesions were treated at least three times at two-week intervals. After intramuscular meperidine premedication, multiple injections of cisplatin mixed with collagen were made into the tumors. There was minimal normal tissue toxicity and minimal systemic toxicity. Tumor regression or stabilization occurred in 86% (12/14) of tumors; 50% (7/14) of lesions regressed more than 50% in size. This study suggests that intralesional colloidal cisplatin can overcome resistance to systemic intravenous cisplatin.
Krag
D N
DN
Division of Surgical Oncology, School of Medicine, University of California, Davis.
Théon
A P
AP
Schneider
P D
PD
Goodnight
J E
JE
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage*; D003094:Collagen; D004337:Drug Carriers; D005240:Feasibility Studies; D006801:Humans; D015552:Injections, Intralesional; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary; D009336:Necrosis; D012074:Remission Induction; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary
D004337:Drug Carriers; D003094:Collagen; D002945:Cisplatin