Efficacy of paraherquamide against immature Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus).
Paraherquamide was 98 to 100 per cent effective against six-day-old Trichostrongylus colubriformis infections in gerbils when given as single oral doses of 1.56 mg kg-1 and above. Doses of 0.78 or 0.39 mg kg-1 were 96 and 66 per cent effective, respectively. A single oral dose of 200 mg kg-1 was well tolerated.
Ostlind
D A
DA
Merck Institute for Therapeutic Research, Rahway, New Jersey.
Mickle
W G
WG
Ewanciw
D V
DV
Andriuli
F J
FJ
Campbell
W C
WC
Hernandez
S
S
Mochales
S
S
Munguira
E
E
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005849:Gerbillinae; D007212:Indolizines / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D015394:Molecular Structure; D013141:Spiro Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D014252:Trichostrongyloidiasis / Q000188:drug therapy*; D014253:Trichostrongylosis / Q000188:drug therapy*
D000871:Anthelmintics; D007212:Indolizines; D013141:Spiro Compounds; C063985:paraherquamide