title: Indium-111 leukocyte scanning and fracture healing.
abstract: This study was undertaken to determine the specificity of indium-111 leukocyte scans for osteomyelitis when fractures are present. Midshaft tibial osteotomies were performed in 14 New Zealand white rabbits, seven of which were infected postoperatively with Staphylococcus aureus per Norden's protocol. All 14 rabbits were scanned following injection with 75 microCi of indium 111 at 72 h after osteotomy and at weekly intervals for 4 weeks. Before the rabbits were killed, the fracture sites were cultured to document the presence or absence of infection. The results of all infected osteotomy sites were positive, whereas no positive scans were found in the noninfected osteotomies. We concluded from this study that uncomplicated fracture healing does not result in a positive indium-111 leukocyte scan.
authors.affiliation: Division of Orthopaedic Surgery, University of Texas Medical School, Houston.
authors.forename: L P
authors.initials: LP
authors.lastname: Mead
authors.forename: A C
authors.initials: AC
authors.lastname: Scott
authors.forename: F J
authors.initials: FJ
authors.lastname: Bondurant
authors.forename: B D
authors.initials: BD
authors.lastname: Browner
mesh_terms: D000818:Animals; D007205:Indium Radioisotopes; D007962:Leukocytes; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000209:etiology; D011817:Rabbits; D011877:Radionuclide Imaging; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013978:Tibial Fractures / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014945:Wound Healing
chemical_list: D007205:Indium Radioisotopes