title: Minimal change glomerulopathy in two patients after thymectomy.
abstract: Two myasthenia gravis patients developed nephrotic syndrome due to minimal change glomerulopathy 3 to 14 years after thymectomy for malignant thymoma. Impaired cellular and humoral immunity has been documented in patients with thymoma and persists after thymectomy. The occurrence of minimal change disease lends support to the hypothesis that the glomerulopathy is secondary to T-cell dysfunction, resulting in production of a lymphokine which increases glomerular basement membrane permeability.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital.
authors.forename: P C
authors.initials: PC
authors.lastname: Chan
authors.forename: C C
authors.initials: CC
authors.lastname: Lau
authors.forename: I K
authors.initials: IK
authors.lastname: Cheng
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: B M
authors.initials: BM
authors.lastname: Jones
authors.forename: M K
authors.initials: MK
authors.lastname: Chan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications*; D009402:Nephrosis, Lipoid / Q000150:complications*; D009404:Nephrotic Syndrome / Q000150:complications*; D013934:Thymectomy; D013945:Thymoma / Q000601:surgery*; D013953:Thymus Neoplasms / Q000601:surgery*