[Modulation of hCG synthesis by alpha tumor necrosis factor in JAR choriocarcinoma cells].
The tumour necrosis factor (TNF) stimulates in cultured JAR choriocarcinoma cells the biosynthesis of hCG, including the free alpha and beta chain and the holo-hCG. Although elevated serum TNF levels have been shown by Balkwill et al. (1987) in about 50% of tumour patients, we were unable to confirm these data in the 10 examined patients, who had a choriocarcinoma. Despite its excellent in-vitro action, INF could not be confirmed to exercise an influence on the regulation of hCG in choriocarcinoma patients.
Marth
C
C
Universitätsklinik für Frauenheilkunde, Osterreichischen Akademie der Wissenschaften, Innsbruck.
Madersbacher
S
S
Herold
M
M
Berger
P
P
Hetzel
H
H
Fuith
L C
LC
Daxenbichler
G
G
D002460:Cell Line; D002822:Choriocarcinoma / Q000097:blood / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000097:blood / Q000473:pathology*
D006063:Chorionic Gonadotropin; D014409:Tumor Necrosis Factor-alpha
Die Modulation der hCG-Synthese durch Tumornekrosefaktor-Alpha bei JAR-Chorionkarzinomzellen.