title: Acute changes in atherogenic and thrombogenic factors with cessation of smoking.
abstract: Tobacco smoking is associated with alterations in several factors considered to be important in the atherosclerotic process. Thirty chronic smokers were studied 2 weeks before and 2 weeks after complete tobacco withdrawal. Significant reductions in fibrinogen, haematocrit, plasma viscosity and whole blood viscosity as well as a significant increase in HDL-cholesterol were observed. As these factors are important in both atherogenesis and thrombogenesis, these observations may give insight into tobacco-induced atherosclerotic disease and may be responsible for the more rapid reduction in the incidence of cardiovascular disease that is believed to occur after stopped smoking.
authors.affiliation: Department of Clinical Pharmacology, St Mary's Hospital Medical School, London.
authors.forename: M D
authors.initials: MD
authors.lastname: Feher
authors.forename: M W
authors.initials: MW
authors.lastname: Rampling
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Robinson
authors.forename: W
authors.initials: W
authors.lastname: Richmond
authors.forename: S
authors.initials: S
authors.lastname: Cholerton
authors.forename: B J
authors.initials: BJ
authors.lastname: Bain
authors.forename: P S
authors.initials: PS
authors.lastname: Sever
mesh_terms: D000328:Adult; D000368:Aged; D001809:Blood Viscosity; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012907:Smoking / Q000097:blood*; D013997:Time Factors
chemical_list: D008076:Cholesterol, HDL; D005340:Fibrinogen