Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease.
There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for alpha-tubulin. The fetal form of alpha-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD.
Geddes
J W
JW
Division of Neurosurgery, University of California, Irvine 92717.
Wong
J
J
Choi
B H
BH
Kim
R C
RC
Cotman
C W
CW
Miller
F D
FD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D005326:Fetal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D014404:Tubulin / Q000378:metabolism*
D005326:Fetal Proteins; D012333:RNA, Messenger; D014404:Tubulin