Hemodynamic responses of the equine digit to intravenous and digital arterial infusion of dopamine.
In 6 adult horses anesthetized with pentobarbital, the hemodynamic responses of the equine digit to infusion of dopamine were evaluated by use of an isolated extra corporeal pump perfused digital preparation. Digital blood flow was maintained at a constant rate that was independent of systemic hemodynamic changes. Three sequential experiments were performed on each horse. In the first experiment (n = 6), dopamine was infused IV at rates of 1.0, 2.5, and 5.0 micrograms/kg/min. For the second experiment (n = 5), dopamine (400 micrograms/ml) was infused into the digital artery at the rates of 0.07, 0.7, and 1.2 ml/min. The third experiment (n = 5) consisted of a 5-minute intra-arterial infusion of phentolamine followed by the intra-arterial infusion of dopamine while continuing the infusion of phentolamine. Digital venous, arterial, and capillary pressures, total digital vascular resistance, and precapillary to postcapillary resistance ratios were determined in each experiment. Systemic infusion of dopamine did not induce changes in the hemodynamics of the digital vasculature. Digital arterial infusion of dopamine alone resulted in a dose-dependent increase in arterial pressure, total digital vascular resistance, and an increase in the precapillary to postcapillary resistance ratio. Phentolamine attenuated the vasoconstrictive response elicited by intra-arterial infusion of dopamine.
Hunt
R J
RJ
Department of Large Animal Medicine, University of Georgia, College of Veternary Medicine, Athens 30602.
Moore
J N
JN
Allen
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists; D005552:Forelimb / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006736:Horses / Q000502:physiology*; D007261:Infusions, Intra-Arterial / Q000662:veterinary; D007263:Infusions, Parenteral / Q000662:veterinary; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D018492:Dopamine Antagonists; D004298:Dopamine; D010646:Phentolamine