title: The molecular nature of allelic diversity for two models of balancing selection.
abstract: This paper provides a theoretical description of the distribution of the number of mutations that separate alleles that are held in a population by balancing selection. Two models of nucleotide site epistasis are described: parity models and additive site models. Parity models are shown to result in a more uniform distribution of mutations across alleles than the neutral model, while additive sites models show a more extreme distribution. The analytic approach uses strong-selection, weak-mutation approximations to constant-fitness and random-environment diffusion models.
authors.affiliation: Department of Genetics, University of California, Davis 95616.
authors.forename: J H
authors.initials: JH
authors.lastname: Gillespie
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D010298:Parity; D011110:Polymorphism, Genetic / Q000235:genetics; D012641:Selection, Genetic
chemical_list: D004247:DNA