The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells.
Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.
Rivedal
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Laboratory for Environmental and Occupational Cancer, Institute for Cancer Research, Montebello, Oslo, Norway.
Mikalsen
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Sanner
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D000818:Animals; D002273:Carcinogens; D002450:Cell Communication / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D004622:Embryo, Mammalian; D004988:Ethers, Cyclic / Q000494:pharmacology*; D007365:Intercellular Junctions / Q000187:drug effects / Q000502:physiology*; D008647:Mesocricetus; D019319:Okadaic Acid; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D002273:Carcinogens; D004988:Ethers, Cyclic; D019319:Okadaic Acid; D013755:Tetradecanoylphorbol Acetate