[Systemic absorption of 2% lidocaine from the lumbar epidural space].
The curves of lidocaine (LDC) plasma levels versus time were evaluated in a group of 16 patients receiving single epidural injections of 2% LDC for each metamer to be anesthesized. LDC absorption from epidural space is fairly rapid (tmax = 17 +/- 4 min and t1/2a = 6.2 +/- 1.7 min). This results in very shape peak plasma levels (2.97 +/- 0.87 micrograms/ml with 2% LDC). The remaining pharmacokinetic parameters were: Ke = 0.0057 +/- 0.0022 min-1 and Vd = 1.5 +/- 0.5 l/kg. In all patients adequate levels for operation were obtained.
Laguarda Rodrigo
M
M
Servicio de Anestesiología y Reanimación, Hospital Lluís Alcanyis, Xàtiva, Valencia.
Sangrador García
G
G
Sánchez Alcaraz
A
A
Botella Miró
J
J
Martínez Durá
J V
JV
Herrero Gracia
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D008012:Lidocaine
Absorción sistémica de la lidocaína al 2% desde el espacio epidural lumbar.