title: Segmental mandibular regeneration by distraction osteogenesis. An experimental study.
abstract: We report the use of distraction osteogenesis for segmental mandibular regeneration. This technique has been used in thousands of patients in the Soviet Union to regenerate as much as 30 cm of tubular bone in the extremities. However, we are unaware of previous experimental or clinical reports of segmental mandibular regeneration by distraction osteogenesis. In a canine model, 2.5-cm segmental mandibular defects were filled with regenerate bone in 25 days at a rate of 1.0 mm/d using bifocal distraction osteogenesis. The diameters of the regenerate segments were comparable with preexisting mandible, and all animals resumed normal oromandibular function following regeneration. The regenerate bone was evaluated radiographically, angiographically, and histologically. In the control group without distraction osteogenesis, the segmental defects failed to fill with regenerate bone. The theoretical basis for distraction osteogenesis, a detailed description of the technique, and a review of previous studies on experimental mandibular lengthening are presented.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: P D
authors.initials: PD
authors.lastname: Costantino
authors.forename: G
authors.initials: G
authors.lastname: Shybut
authors.forename: C D
authors.initials: CD
authors.lastname: Friedman
authors.forename: H J
authors.initials: HJ
authors.lastname: Pelzer
authors.forename: M
authors.initials: M
authors.lastname: Masini
authors.forename: M L
authors.initials: ML
authors.lastname: Shindo
authors.forename: G A
authors.initials: GA
authors.lastname: Sisson
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D004285:Dogs; D008334:Mandible / Q000502:physiology* / Q000601:surgery; D009984:Orthopedic Fixation Devices; D010012:Osteogenesis; D013997:Time Factors