title: Cytosol progesterone and 17 alpha-hydroxyprogesterone levels and luteinizing hormone and chorionic gonadotropin receptors in human corpora lutea.
abstract: Cytosol progesterone (P) and 17 alpha-hydroxyprogesterone (17-OHP) levels and luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptors were measured in 27 corpora lutea and four corpora albicantia. Cytosol P concentrations were highest in corpora lutea (mean +/- SEM, 3.1 +/- 0.8 micrograms/g) during the midluteal phase (days 15 to 19) rather than the early (2.2 +/- 0.8 micrograms/g, days 20 to 25) and late luteal phases (1.8 +/- 0.8 micrograms/g, days 26 to 30). Cytosol 17-OHP concentrations also were 3.3 +/- 0.5, 4.3 +/- 0.6, and 3.3 +/- 1.0 micrograms/g in early, midluteal, and late luteal phases, respectively, and was significantly inversely correlated with occupied LH/hCG receptors in midluteal phase. Corpora albicantia had the lowest P (0.3 +/- 0.05 microgram/g) and 17-OHP (0.9 +/- 0.6 micrograms/g) concentrations. Cytosol P and 17-OHP may therefore reflect the balance between the luteal cell production and secretion, whereas the amount of occupied and unoccupied LH/hCG receptors may partially explain the relationship between LH and P secretion.
authors.affiliation: Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago.
authors.forename: T R
authors.initials: TR
authors.lastname: Yeko
authors.forename: F S
authors.initials: FS
authors.lastname: Khan-Dawood
authors.forename: M Y
authors.initials: MY
authors.lastname: Dawood
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000328:Adult; D002462:Cell Membrane / Q000032:analysis; D003338:Corpus Luteum / Q000032:analysis*; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000032:analysis*; D008597:Menstrual Cycle; D011374:Progesterone / Q000032:analysis*; D011974:Receptors, LH / Q000032:analysis*; D012016:Reference Values
chemical_list: D006908:Hydroxyprogesterones; D011974:Receptors, LH; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone