Experimental assessment of phased-array heating of neck tumours.
An investigation of phased-array microwave systems (PAMS) for non-invasively inducing hyperthermia, primarily in neck lesions, has been done with implications for applications at other sites such as lung and pelvis. Our general approach was to combine numerical and analytical approaches with parallel experimental studies. In this paper we will concentrate only on the experimental aspects. The object, such as a homogeneous cylindrical phantom or a neck phantom, was encircled with several standard applicators driven by a single source, but with relative phase and amplitude control over each applicator. The relative phases of the applicators were adjusted by using an implanted monopole antenna connected to an HP network analyser. Power was applied and the specific absorption rate (SAR) was determined by using split phantoms and thermography or by measuring temperature transients dT/dt, recorded by implanted thermometer probes. We found that at 915 MHz for our applicators (SMA Co.) the centre of an 11 cm diameter muscle-like phantom heated to about 33% of the value at the surface in front of the applicator. Similarly, we were able to show significant SAR at the centre of realistically sized neck phantoms using four phased apertures of 915 MHz. Furthermore, substantial improvement was observed if the frequency was lowered to about 400 MHz.
Gross
E J
EJ
University of Arizona, Department of Radiation Oncology, Tucson 85724.
Cetas
T C
TC
Stauffer
P R
PR
Liu
R L
RL
Lumori
M L
ML
D000818:Animals; D004285:Dogs; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D008872:Microwaves / Q000627:therapeutic use; D008953:Models, Anatomic; D013814:Thermal Conductivity; D013817:Thermography; D013821:Thermometers