title: [Treatment of acute chloroquine poisoning].
abstract: Acute chloroquine poisoning is life threatening with risk of death from apnoea and cardiac arrhythmia within a few hours of ingestion. Mechanical ventilation, infusion of pressor agents and large doses of diazepam seem to provide effective treatment. This treatment was introduced by Riou et alii (N Engl J Med 1988; 318; 1-6), and we used it successfully in a case of severe chloroquine poisoning. Intensive treatment was given during the first two days of intoxication, when the whole blood chloroquine phosphate concentration was high (more than 10 mumol/kg), corresponding to absorption from the gut and distribution to the organs. Hereafter the whole blood chloroquine phosphate concentration decreased increasingly slowly, probably due to equilibrium with tissue stores.
authors.affiliation: Odense Sygehus, medicinsk afdeling C.
authors.forename: A H
authors.initials: AH
authors.lastname: Siboni
authors.forename: A C
authors.initials: AC
authors.lastname: Hansen
authors.forename: C E
authors.initials: CE
authors.lastname: Bruun-Mogensen
authors.forename: P F
authors.initials: PF
authors.lastname: Nielsen
authors.forename: I A
authors.initials: IA
authors.lastname: Jacobsen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002738:Chloroquine / Q000506:poisoning*; D003975:Diazepam / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012121:Respiration, Artificial
chemical_list: D004280:Dobutamine; D002738:Chloroquine; D003975:Diazepam
vernacular_title: Behandling af akut klorokinforgiftning.