title: Significance of histological prognostic indicators in patients with carcinoma of the prostate.
abstract: The relationship between histological prognostic indicators and their relative significance in prognosis were studied in 139 patients who underwent radical prostatectomy. The estimated progression rates at 5 and 8 years were 14 and 52% respectively for patients with high grade tumours, 25 and 50% for those with capsular penetration, 31 and 58% for patients with seminal vesicle invasion and 23 and 55% for those with lymph node metastases. Each of the 4 parameters yielded an approximately equal increased risk of disease progression at 5 and 8 years. The occurrence of 2 or more risk factors in the same patient did not result in a statistically increased risk of progression at 5 and 8 years. The effect of capsular involvement on progression was directly related to the extent of invasion. The progression rate at 8 years was 3% for patients with mild involvement, 19% for those with extensive invasion and 50% for those with capsular penetration.
authors.affiliation: Department of Surgery, UCLA School of Medicine.
authors.forename: E
authors.initials: E
authors.lastname: Mukamel
authors.forename: J B
authors.initials: JB
authors.lastname: deKernion
authors.forename: F
authors.initials: F
authors.lastname: Dorey
authors.forename: J
authors.initials: J
authors.lastname: Hannah
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*; D012306:Risk; D012669:Seminal Vesicles / Q000473:pathology