title: Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and beta-interferon. Time course of intracranial pressure.
abstract: A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir and beta-interferon. The increase in intracranial pressure during the second week was well controlled by ICP monitoring. Life-threatening pressure peaks were avoided through the use of thiopental, osmodiuretics, TRIS, and lidocaine.
authors.affiliation: Innere Medizin IV, Universitätsklinik Ulm.
authors.forename: A
authors.initials: A
authors.lastname: Schmidt
authors.forename: D
authors.initials: D
authors.lastname: Bunjes
authors.forename: J
authors.initials: J
authors.lastname: Friedrich
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.forename: T
authors.initials: T
authors.lastname: Eggeling
authors.forename: V
authors.initials: V
authors.lastname: Hombach
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D001925:Brain Damage, Chronic / Q000175:diagnosis; D003131:Combined Modality Therapy; D004660:Encephalitis / Q000175:diagnosis / Q000628:therapy*; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D009460:Neurologic Examination
chemical_list: D007370:Interferon Type I; D000212:Acyclovir