Influence of midazolam on the plasma concentrations of mepivacaine after lumbar epidural injection in children.
Twenty children undergoing surgery received a lumbar block using 0.4 ml/kg mepivacaine 2.0%. They were randomized into two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration did not significantly influence the plasma concentrations of mepivacaine.
Giaufre
E
E
Surgical Pediatric Department, Saint-Joseph Fondation Hospital, Marseille, France.
Bruguerolle
B
B
Morisson-Lacombe
G
G
Rousset-Rouviere
B
B
D000293:Adolescent; D000767:Anesthesia, Epidural; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D008874:Midazolam / Q000494:pharmacology*; D011229:Preanesthetic Medication; D011897:Random Allocation
D008619:Mepivacaine; D008874:Midazolam