title: Comparison of 31P MRS and 1H MRI at 1.5 and 2.0 T.
abstract: The goals of this study were to compare 31P magnetic resonance spectroscopy (MRS) and 1H magnetic resonance imaging (MRI) of human subjects and phantoms at 1.5 and 2.0 T. The 31P signal-to-noise (S/N) ratios in phantom standards and in localized volumes in human brain and liver were compared at 1.5 and 2.0 T. In addition, T1 values for 31P resonances in human brain, 31P linewidths of metabolites in human brain and liver, 1H S/N in a phantom standard, and MR image quality in human head and body were compared at the two field strengths. The results of our study showed that at the higher strength field, (1) in vivo 31P MRS studies benefited from up to 32% improvement in S/N; (2) in vivo 31P MRS studies also benefited from increased spectral dispersion; (3) the quality of MR head images remained comparable; and (4) body images showed some decrease in image quality due to increased chemical shift, and flow and motion artifacts.
authors.affiliation: MRS Unit, Veterans Administration Medical Center, San Francisco, California.
authors.forename: M D
authors.initials: MD
authors.lastname: Boska
authors.forename: B
authors.initials: B
authors.lastname: Hubesch
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyerhoff
authors.forename: D B
authors.initials: DB
authors.lastname: Twieg
authors.forename: G S
authors.initials: GS
authors.lastname: Karczmar
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D001921:Brain / Q000378:metabolism; D006801:Humans; D006859:Hydrogen; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation; D008961:Models, Structural; D010758:Phosphorus; D013997:Time Factors
chemical_list: D010758:Phosphorus; D006859:Hydrogen