title: Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life.
abstract: The developmental profiles of the gangliosides and those of the fatty acids and long-chain bases of the total ganglioside mixture of the brain of chicken were followed from the 10th day of incubation to the 63rd posthatching day. One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry. Besides a number of gangliosides identified by co-chromatography with reference standards, 10 were of unidentified structure, and within these 4 did not belong to the gangliotetrahexosyl series. Throughout embryonic life, the ceramide portion of gangliosides was found to contain the long-chain base species with 18 carbons. Those with 20 carbons, approximately 10% of the total, were found to be present only after hatching.
authors.affiliation: Department of Medical Chemistry and Biochemistry, Medical School, University of Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sonnino
authors.forename: R
authors.initials: R
authors.lastname: Bassi
authors.forename: V
authors.initials: V
authors.lastname: Chigorno
authors.forename: G
authors.initials: G
authors.lastname: Tettamanti
mesh_terms: D000468:Alkalies / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002642:Chick Embryo / Q000378:metabolism*; D002645:Chickens; D004355:Drug Stability; D005732:Gangliosides / Q000378:metabolism*; D050356:Lipid Metabolism
chemical_list: D000468:Alkalies; D005732:Gangliosides