Induction of multifocal pancreatic cancer after inoculation of hamster pancreatic cancer cell line (PC-1) into a defined area of homologous pancreatic tissue.
Inoculation of the pancreatic cancer cell line PC-1 into a defined area of the tail of the hamster pancreas led to development of multiple cancerous foci in the body of the pancreas along the main pancreatic duct. Each carcinoma showed identical histological characteristics and was completely separated from the others by regions of normal pancreatic tissue. This observation suggests spread of the cancer from the primary site in discontinuity through the ductal system of the pancreas.
Egami
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H
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68105.
Takiyama
Y
Y
Pour
P M
PM
D000818:Animals; D006224:Cricetinae; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000473:pathology*; D014407:Tumor Cells, Cultured