A novel cardio-excitatory peptide isolated from the atria of the African giant snail, Achatina fulica.
An undecapeptide which potentiates the beat of the ventricle in the African giant snail, Achatina fulica Ferussac, was purified from the atria of the snail. Its primary structure was determined to be H-Ser-Gly-Gln-Ser-Trp-Arg-Pro-Gln-Gly-Arg-Phe-NH2. This peptide was found to have excitatory actions not only on the ventricle but also on the penis retractor muscle, the buccal muscle and the identified neurons controlling the buccal muscle movement of Achatina.
Fujimoto
K
K
Physiological Laboratory, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Ohta
N
N
Yoshida
M
M
Kubota
I
I
Muneoka
Y
Y
Kobayashi
M
M
D000595:Amino Acid Sequence; D000818:Animals; D016275:Atrial Function; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009132:Muscles / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D012908:Snails / Q000502:physiology*
D009479:Neuropeptides; C063480:Achatina cardio-excitatory peptide 1