Neurological outcome after a severe herpes simplex encephalitis treated with acyclovir and beta-interferon. Time course of intracranial pressure.
A severe herpes simplex encephalitis with documented intra-cerebral lesions and brain edema was treated successfully with acyclovir and beta-interferon. The increase in intracranial pressure during the second week was well controlled by ICP monitoring. Life-threatening pressure peaks were avoided through the use of thiopental, osmodiuretics, TRIS, and lidocaine.
Schmidt
A
A
Innere Medizin IV, Universitätsklinik Ulm.
Bunjes
D
D
Friedrich
J
J
Koenig
W
W
Eggeling
T
T
Hombach
V
V
D000212:Acyclovir / Q000627:therapeutic use*; D000328:Adult; D001925:Brain Damage, Chronic / Q000175:diagnosis; D003131:Combined Modality Therapy; D004660:Encephalitis / Q000175:diagnosis / Q000628:therapy*; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D009460:Neurologic Examination
D007370:Interferon Type I; D000212:Acyclovir