Immunoreactive circulating alpha-interferon is low in Sjögren's syndrome.
Circulating alpha-interferon in plasma of 26 patients with Sjögren's syndrome was 0.069 +/- 0.034 ng/ml, a significant decrease compared with 0.119 +/- 0.051 ng/ml for age- and sex-matched healthy subjects (P less than 0.01) and compared with values previously found for healthy donors at ages 1-89 years. The results indicate the inability of Sjögren's syndrome patients to maintain circulating alpha-interferon.
Shiozawa
S
S
Department of Medicine, Kobe University School of Medicine, Japan.
Shiozawa
K
K
Shimizu
S
S
Tanaka
Y
Y
Morimoto
I
I
Yoshihara
R
R
Kuroki
Y
Y
Hashimoto
M
M
Fujita
T
T
D000328:Adult; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values; D012859:Sjogren's Syndrome / Q000097:blood*
D007370:Interferon Type I