[Lipid peroxidation as a biological marker of mucosal changes in the stomach].
Dose-related increase of malondialdehyde (MDA) was found in both gastric mucosa and urine after 5-week administration of 4.0, 2.0, 1.0, 0.5, 0.25 or 0% NaCl supplemented diet to rats. NaCl, a gastric tumor promoter, is associated with enhanced lipid peroxidation in the gastric mucosa. The urinary MDA level was found to be a good indicator of lipid peroxidation state in the gastric mucosa, higher levels of MDA in the urine clearly correlating with data for stomach glandular tissue. In man, elevation of MDA was also observed in the urine of patients with gastric lesions such as chronic gastritis, precancerous and cancer, as well as in individuals suffering from liver and kidney disease.
Takahashi
M
M
Dept. of Community Health Science, Saga Medical School.
Furukawa
F
F
Okamiya
H
H
Shinoda
K
K
Uneyama
C
C
Hasegawa
T
T
D000818:Animals; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005756:Gastritis / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000652:urine*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000378:metabolism; D013276:Stomach Ulcer / Q000378:metabolism
D008054:Lipid Peroxides; D012965:Sodium Chloride