Involvement of plasmids in Streptomyces incarnatus phenotype.
The sinefungin producing, pock forming strain Streptomyces incarnatus was shown to be thiostrepton resistant. However, it does not produce thiostrepton and structurally related antibiotics. In this strain, five low copy plasmids of variable sizes were detected with electron microscopy. The strain S. lividans TK24 became thiostrepton resistant upon transformation by one of the plasmids of S. incarnatus.
Malina
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Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Robert-Gero
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000648:ultrastructure; D004270:DNA, Circular / Q000648:ultrastructure; D004352:Drug Resistance, Microbial / Q000235:genetics; D008854:Microscopy, Electron; D010641:Phenotype; D010957:Plasmids; D013302:Streptomyces / Q000235:genetics* / Q000648:ultrastructure; D013883:Thiostrepton / Q000494:pharmacology*; D014169:Transformation, Bacterial
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004270:DNA, Circular; D013883:Thiostrepton