title: Gallstone fragmentation with contact electrohydraulic lithotripsy: in vitro study of physical and technical factors.
abstract: To identify physical and technical factors that have an effect on fragmentation, the authors performed in vitro contact electrohydraulic lithotripsy (EHL) on gallstones 10 mm or larger in size. Of 122 gallstones, 113 (93%) could be fragmented with 1-46 pulses from a 3-F electrode (average, 10 pulses). Only 12 of the 113 stones could be fragmented with a single spark. Of the nine stones that did not fragment with 50 pulses from a 3-F electrode, four were larger than 30 mm in diameter, and five were seen at radiography to be heavily calcified; all of these stones were fragmented with five or fewer pulses from a 9-F electrode. Stone capture in a wire basket facilitated fragmentation of gallstones of all sizes, but particularly those stones 15 mm or larger. Contact EHL could be performed as well in a 1:1 dilute diatrizoate irrigating solution as in 1:6 normal saline. A significantly greater number of pulses was required to fragment gallstones 15 mm in diameter or larger compared with stones smaller than 15 mm (P less than .01). In addition, stones 15 mm or smaller had a greater tendency to fragment into "gravel" (ie, fragments measuring 2 mm or less), while EHL of stones larger than 15 mm produced larger, discrete fragments of approximately equal size (P less than .05). EHL of heavily calcified gallstones required a significantly greater number of pulses than EHL of less calcified or noncalcified stones (P less than .002).
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114.
authors.forename: G A
authors.initials: GA
authors.lastname: Tung
authors.forename: P R
authors.initials: PR
authors.lastname: Mueller
authors.forename: J A
authors.initials: JA
authors.lastname: Brink
authors.forename: S
authors.initials: S
authors.lastname: Saini
authors.forename: J T
authors.initials: JT
authors.lastname: Ferrucci
mesh_terms: D002769:Cholelithiasis / Q000628:therapy*; D003973:Diatrizoate; D006801:Humans; D066298:In Vitro Techniques; D008096:Lithotripsy / Q000379:methods*; D015642:Radiology, Interventional; D007507:Therapeutic Irrigation
chemical_list: D003973:Diatrizoate