[The effect of inducers of microsomal enzymes on glucose transport in the kidneys].
Phenobarbital (50 mg/kg), benzonal (35 mg/kg) and zixorine (100 mg/kg) administered orally for 4 days and 3-methylcholanthrene (20 mg/kg) administered subcutaneously for 2 days decreased the maximal tubular transport of glucose in rats. Phenobarbital (10 mg/kg) given orally for 8-10 days reduced the tubular reabsorption of glucose in dogs. An increase of phenobarbital dose enhanced and prolonged its effect on the renal tubular transport of glucose.
Ul'ianov
G P
GP
Lampatov
V V
VV
D000042:Absorption; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D007444:Inulin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008748:Methylcholanthrene / Q000494:pharmacology; D008861:Microsomes / Q000187:drug effects* / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D001463:Barbiturates; D001559:Benzhydryl Compounds; D008748:Methylcholanthrene; D007444:Inulin; D005947:Glucose; C016914:flumecinol; C002915:benzobarbital; D010634:Phenobarbital
Vliianie induktorov mikrosomal'nykh fermentov na transport gliukozy v pochkakh.