Rabies Vaccine Adsorbed: neutralizing antibody titers after three-dose pre-exposure vaccination.
Field trials at several schools of veterinary medicine showed that three-dose pre-exposure rabies vaccination with Rabies Vaccine Adsorbed developed by the Michigan Department of Health elicited neutralization antibody in practically all recipients two to three weeks after immunization. Titers declined during the first six months after vaccination. However, by 18 to 24 months, 98 percent of recipients still had titers equal or greater than a 1:5 dilution of serum.
Berlin
B S
BS
Bureau of Laboratory and Epidemiological Services, Michigan Department of Public Health, Lansing 48909.
D000276:Adjuvants, Immunologic; D000327:Adsorption; D000328:Adult; D000535:Aluminum; D017607:Aluminum Compounds; D000914:Antibodies, Viral / Q000302:isolation & purification*; D006801:Humans; D009500:Neutralization Tests; D010710:Phosphates; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D011820:Rabies virus / Q000276:immunology*
D000276:Adjuvants, Immunologic; D017607:Aluminum Compounds; D000914:Antibodies, Viral; D010710:Phosphates; D011819:Rabies Vaccines; D000535:Aluminum; C012714:aluminum phosphate