Androgen receptors--a method to measure functional behaviour in human prostatic cancer.
Androgen receptors were measured in soluble and nuclear fractions of tissues obtained from 25 patients. A method using mibolerone, a synthetic androgen, as a ligand is described. This method, which includes the presence of excess ORG 2058 to eliminate interaction with progesterone receptors, gives a reliable determination of androgen receptor content and has been used to predict response to hormonal treatment. However, the results suggest that the presence of functional receptor is not, in itself, a sufficient index of hormonal dependence of the tumour.
Kirkali
Z
Z
Western Infirmary Department of Urology, Glasgow University, UK.
Moffat
L E
LE
Leake
R
R
Cowan
S
S
Patel
M
M
Kirk
D
D
D000368:Aged; D000369:Aged, 80 and over; D004054:Diethylstilbestrol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000188:drug therapy / Q000601:surgery; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen; D004054:Diethylstilbestrol