title: Dilutional acidosis.
abstract: Rapid, extreme expansion of the extracellular fluid with solutions devoid of acid or alkali theoretically can produce a metabolic acidosis, due to buffer dilution. This phenomenon has previously been demonstrated only in experimental animal studies. We have reported what we believe to be the first documented case of hypobicarbonatemia and metabolic acidosis consequent to massive saline infusion, other causes having been excluded.
authors.affiliation: Kraftsow Division of Nephrology, Albert Einstein Medical Center, Philadelphia, Pa.
authors.forename: D A
authors.initials: DA
authors.lastname: Goodkin
authors.forename: R M
authors.initials: RM
authors.lastname: Raja
authors.forename: A
authors.initials: A
authors.lastname: Saven
mesh_terms: D000138:Acidosis / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D002021:Buffers; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D001639:Bicarbonates; D002021:Buffers; D012965:Sodium Chloride