title: Non-M CK--a practical measure of creatine kinase isoenzymes in cancer patients.
abstract: The individual creatinine kinase (CK) isoenzymes CK-BB and CK-Macro II have previously been investigated as potential tumour markers. We believe there is a need for a system to measure those CK forms not usually present in serum. We have studied a CK-MB immunoinhibition kit which measures all residual CK activity following inactivation of M-subunit activity. In 162 patients with cancer we found no difference in grading (+ or -) between detailed isoenzyme studies and the simple non-M assay. In 33 samples with elevated non-M CK, detailed analysis showed BB alone (45%), Macro II alone (9%), or both (36%). Raised activities were mainly found in patients with small cell lung cancer (SCLC) (17/40; 43%) and GI Tumours (6/11; 55%). In patients with SCLC, elevated activities were associated with disseminated disease. Preliminary evidence indicates that Non-M CK may also be a simple means of monitoring initial treatment response.
authors.affiliation: Department of Biochemistry, Mater Hospital, Dublin, Ireland.
authors.forename: P G
authors.initials: PG
authors.lastname: McGing
authors.forename: M
authors.initials: M
authors.lastname: Teeling
authors.forename: A
authors.initials: A
authors.lastname: McCann
authors.forename: F
authors.initials: F
authors.lastname: Kyne
authors.forename: D N
authors.initials: DN
authors.lastname: Carney
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D009369:Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase