title: Urinary 1-hydroxypyrene as an indicator of human exposure to ambient polycyclic aromatic hydrocarbons in a coal-burning environment.
abstract: Urinary 1-hydroxypyrene of residents of Beijing, Shenyang and Taiyuan, and workers at two coke plants, a steel plant and control groups was determined using high pressure liquid chromatography. Polycyclic aromatic hydrocarbons (PAHs) of airborne particulates from these cities and coke plants were analyzed using GC-MS; chromatogram profiles, from which 15 chemical compounds were quantified, were similar. The percentage of pyrene and benzo[a]pyrene in PAHs was fairly constant. Statistical analysis showed significant correlation of urinary 1-hydroxypyrene with the concentration of pyrene and benzo[a]pyrene in the ambient PAHs; the correlation coefficient was 0.978 and 0.959, respectively. It is suggested that urinary 1-hydroxypyrene can be used as a biological monitoring index for human exposure to genotoxic PAHs from the burning of coal.
authors.affiliation: Beijing Municipal Research Institute of Environmental Protection, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhao
authors.forename: W Y
authors.initials: WY
authors.lastname: Quan
authors.forename: D H
authors.initials: DH
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000328:Adult; D000397:Air Pollution / Q000032:analysis*; D002648:Child; D002681:China; D003031:Coal; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011083:Polycyclic Compounds / Q000378:metabolism* / Q000633:toxicity; D011721:Pyrenes / Q000378:metabolism*
chemical_list: D003031:Coal; D011083:Polycyclic Compounds; D011721:Pyrenes; C033146:1-hydroxypyrene