Two different lymph node metastatic patterns of a prostatic cancer.
Among 753 autopsy prostatic cancer cases with a metastasis, 476 (63%) had a lymph node metastasis, whereas 277 (37%) did not. Two different lymph node metastatic patterns were observed: Type 1, combined metastasis involving the pelvic and paraaortic lymph nodes; and Type 2, metastasis to the paraaortic lymph nodes, but not to the pelvic lymph nodes. Type 1 metastasis cases showed a significantly more frequent metastasis to the bladder and rectum, and a less frequent metastasis to the lungs and liver. Hydronephrosis occurred more frequently (P less than 0.01) in the Type 1. Furthermore, in the Type 1 cases the lymph node metastasis appeared to be continuously invasive, but in the Type 2 cases, metastasis appeared to be the skip type or some metastases may have spread via the vertebral vein bypass route and may have been associated with a hematogenous metastasis.
Saitoh
H
H
Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan.
Yoshida
K
K
Uchijima
Y
Y
Kobayashi
N
N
Suwata
J
J
Kamata
S
S
D001011:Aorta; D001859:Bone Neoplasms / Q000556:secondary; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D008113:Liver Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D010388:Pelvis; D011471:Prostatic Neoplasms / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000556:secondary