Effect of pancreatic enzymes in non-ulcer dyspepsia. A pilot study.
The symptomatic effect of pancreatic enzymes was examined in 37 patients with non-ulcer dyspepsia (NUD) recruited from general practice by means of a 24-day multicrossover model (MCOM) including six treatment periods and five regular interchanges between pancreatic enzymes and placebo. The evaluation was based on a comparison of the enzyme- and placebo-associated symptoms and on the number of times pancreatic enzymes were associated with less symptoms than the preceding or following placebo period in individual patients. No evidence of a short-term effect of pancreatic enzymes in NUD was found.
Kleveland
P M
PM
Dept. of Medicine, Regional and University Hospital of Trondheim, Trondheim, Norway.
Johannessen
T
T
Kristensen
P
P
Løge
I
I
Sandbakken
P
P
Dybdahl
J
J
Petersen
H
H
D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D010865:Pilot Projects; D016037:Single-Blind Method