Myocardial infarction following sublingual administration of isosorbide dinitrate.
A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstream to significant coronary arterial stenosis in the pathophysiology of acute coronary insufficiency.
Scardi
S
S
Department of Cardiology, Ospedale Maggiore, Trieste, Italy.
Zingone
B
B
Pandullo
C
C
D000286:Administration, Sublingual; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000009:adverse effects*; D009203:Myocardial Infarction / Q000139:chemically induced*
D007548:Isosorbide Dinitrate