Glucose conservation by the kidney and effect of systemic glucose infusion on inulin clearance in female goats.
In 6 female goats, the mean threshold for glucosuria was 159.5 +/- 4.3 mg/dl. During increasing filtered loads of glucose, renal reabsorption of glucose reached maximal capacity, which was not exceeded when plasma glucose concentration was increased further. Measured in 10 female goats, the transport maximum for glucose was 119.1 +/- 9.1 mg of glucose reabsorbed/min. During infusion of glucose, there was a significant (P less than 0.05) time-dependent reduction in inulin clearance indicating that IV glucose administration may be inappropriate in goats with compromised renal function.
Brown
S A
SA
Department of Physiology and Pharmacology, College of Veterinary Medicine, University University of Georgia, Athens 30602.
Barsanti
J A
JA
Finco
D R
DR
D000818:Animals; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006029:Glycosuria / Q000139:chemically induced / Q000662:veterinary*; D006041:Goats / Q000502:physiology*; D007262:Infusions, Intravenous / Q000662:veterinary; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D007677:Kidney Function Tests / Q000662:veterinary; D008657:Metabolic Clearance Rate; D013997:Time Factors
D005947:Glucose