title: Studies of wall shear and mass transfer in a large scale model of neonatal high-frequency jet ventilation.
abstract: The problem of endotracheal erosion associated with neonatal high-frequency jet ventilation (HFJV) is investigated through measurement of air velocity profiles in a scaled up model of the system. Fluid mechanical scaling principles are applied in order to construct a model within which velocity profiles are measured by hot-wire anemometry. The effects of two different jet geometries are investigated. Velocity gradients measured near the tracheal wall are used to measure the shear stresses caused by the jet flow on the wall. The Chilton-Colburn analogy between the transport of momentum and mass is applied to investigate tracheal drying caused by the high shear flow. Shear forces are seen to be more than two times higher for jets located near the endotracheal tube wall than for those located axisymmetrically in the center of the tube. Since water vapor fluxes are dependent on these shears, they are also higher for the asymmetric case. Fluxes are shown to be greatly dependent on the temperature and relative humidity of the inspired gas. Water from the tracheal surface may be depleted within one second if inspired gases are inadequately heated and humidified. It is recommended that the design of neonatal HFJV devices include delivery of heated (near body temperature), humidified (as close to 100% humidity as possible) gases through an axisymmetric jet to best avoid the problem of endotracheal erosion.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia 19104-6392.
authors.forename: W J
authors.initials: WJ
authors.lastname: Muller
authors.forename: S
authors.initials: S
authors.lastname: Gerjarusek
authors.forename: P W
authors.initials: PW
authors.lastname: Scherer
mesh_terms: D006611:High-Frequency Jet Ventilation / Q000009:adverse effects; D006801:Humans; D006813:Humidity; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008954:Models, Biological; D009079:Mucociliary Clearance / Q000502:physiology; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology; D012212:Rheology; D013314:Stress, Mechanical; D013696:Temperature; D014132:Trachea / Q000033:anatomy & histology / Q000502:physiology*; D014136:Tracheitis / Q000209:etiology / Q000503:physiopathology; D014783:Viscosity