title: Alteration of vitamin D metabolism in Mexican-Americans.
abstract: Studies were performed to investigate vitamin D metabolism in Mexican-Americans. Groups of 15 whites and 16 Mexican-Americans ranging in age from 18 to 41 years were evaluated. All of them were within 25% of their ideal body weight. Each of them was admitted to the Clinical Research Center of the University of Texas Health Science Center and placed on a daily diet estimated to contain 400 mg calcium and 900 mg phosphate. It was found that whereas serum vitamin D (1.8 +/- 0.5 versus 7.6 +/- 1.3 ng/ml, P less than 0.001) and serum 25-hydroxyvitamin D (9 +/- 1 versus 17 +/- 2 ng/ml, P less than 0.01) were significantly lower and serum 1,25-dihydroxyvitamin D (37 +/- 2 versus 28 +/- 2 pg/ml, P less than 0.001) was significantly higher in the Mexican-Americans than in the whites, serum calcium (9.1 +/- 0.1 versus 9.2 +/- 0.1 mg/dl), magnesium (1.84 +/- 0.07 versus 1.80 +/- 0.07 mEq/liter), and Gla protein (19 +/- 3 versus 21 +/- 2 ng/ml) were not different in the two groups. Urinary calcium (144 +/- 14 versus 124 +/- 16 mg/day), phosphate (672 +/- 51 versus 683 +/- 44 mg/day), sodium (110 +/- 8 versus 99 +/- 9 mEq/day), potassium (43 +/- 4 versus 49 +/- 3 mEq/day), and magnesium (7.3 +/- 0.7 versus 7.7 +/- 0.5 mEq/day) and creatinine clearance (173 +/- 14 versus 154 +/- 7 liters/day) were not different in the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Texas Health Science Center, San Antonio.
authors.forename: C A
authors.initials: CA
authors.lastname: Reasner
authors.forename: J F
authors.initials: JF
authors.lastname: Dunn
authors.forename: D A
authors.initials: DA
authors.lastname: Fetchick
authors.forename: Y
authors.initials: Y
authors.lastname: Liel
authors.forename: B W
authors.initials: BW
authors.lastname: Hollis
authors.forename: S
authors.initials: S
authors.lastname: Epstein
authors.forename: J
authors.initials: J
authors.lastname: Shary
authors.forename: G R
authors.initials: GR
authors.lastname: Mundy
authors.forename: N H
authors.initials: NH
authors.lastname: Bell
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006403:Hematologic Tests; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D