Lack of effect of atenolol and nadolol on the metabolism of theophylline.
The effects of 7 days of pretreatment with atenolol, 150 mg day-1, or nadolol, 80 mg day-1, on the pharmacokinetics and metabolism of theophylline were determined in six male smokers. Theophylline clearance, volume of distribution, half-life and the urinary excretion of theophylline and its metabolites were unchanged during either treatment compared with control.
Corsi
C M
CM
Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.
Nafziger
A N
AN
Pieper
J A
JA
Bertino
J S
JS
D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D009248:Nadolol / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism; D013806:Theophylline / Q000493:pharmacokinetics*
D009248:Nadolol; D001262:Atenolol; D013806:Theophylline