Anti-class II beta-chain antibodies in the serum and synovial fluid of rheumatoid arthritis patients.
Sera and synovial fluid (SF) from rheumatoid arthritis (RA) patients were evaluated for anti-HLA class II beta-chain antibodies using single and two-dimensional immunoblots. The antibodies from RA sera and SFs which reacted with class II beta-chain determinants were predominantly IgM and IgA with minimal IgG. This reactivity was also present in SFs from other rheumatic diseases. Anti-class II beta-chain antibodies were also shown to be present simultaneously in RA sera and SF.
Marnell
L L
LL
Division of Biomedical Research, Lovelace Medical Foundation, Albuquerque, New Mexico 87108.
Searles
R P
RP
Savage
S M
SM
Jaramillo
Y
Y
Sibbitt
W L
WL
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007132:Immunoglobulin Isotypes / Q000032:analysis; D013582:Synovial Fluid / Q000276:immunology
D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II; D007132:Immunoglobulin Isotypes