title: [Cytochrome P-450 induction and the subsequent induction of an immune response in rats during the chronic administration of xenobiotics].
abstract: The long-term administration of xenobiotics carcinogens o-aminoazotoluene (o-AAT) and benz(a)pyrene (BP) to rats was found to cause induction of the liver cytochrome P-450 system which gradually decreases in spite of continued administration of the agents. Induction of microsomal oxygenases under these conditions is followed by induction of the immune response to o-AAT and BP. The data obtained correspond to the conception of the immunochemical functional system of homeostasis implying that the cytochrome-450 system and the immunity system are functionally linked and are elements of the common functional adaptive system of the organism.
authors.forename: I E
authors.initials: IE
authors.lastname: Kovalev
authors.forename: N V
authors.initials: NV
authors.lastname: Shipulina
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Tomilina
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D001564:Benzo(a)pyrene / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D051381:Rats; D013997:Time Factors; D015262:Xenobiotics / Q000494:pharmacology*; D009762:o-Aminoazotoluene / Q000494:pharmacology
chemical_list: D015262:Xenobiotics; D001564:Benzo(a)pyrene; D003577:Cytochrome P-450 Enzyme System; D009762:o-Aminoazotoluene
vernacular_title: Induktsiia tsitokhroma P-450 i posleduiushchaia induktsiia immunnogo otveta u krys pri khronicheskom vvedenii ksenobiotikov.