Human leukocyte antigens -A, -B, -C, and -DR and nasopharyngeal carcinoma in northern China.
We observed HLA associations in patients with nasopharyngeal carcinoma from northern China. There was an increased risk of nasopharyngeal carcinoma associated with HLA-B35 and a difference in the HLA association between patients with early- and late-onset disease. The frequency of B35 was significantly higher in patients than in control subjects, especially in early-onset patients (less than 30 years old). Late-onset patients had a higher frequency of DR2 as compared with normal subjects.
Zhu
X N
XN
Beijing Institute of Otorhinolaryngology, People's Republic of China.
Chen
R
R
Kong
F H
FH
Liu
W
W
D000328:Adult; D000367:Age Factors; D002277:Carcinoma / Q000276:immunology*; D002681:China; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000032:analysis* / Q000235:genetics; D015789:HLA-A2 Antigen / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics; D015797:HLA-B35 Antigen / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis* / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D015802:HLA-DR2 Antigen / Q000032:analysis; D015804:HLA-DR4 Antigen / Q000032:analysis; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*
D015234:HLA-A Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D015797:HLA-B35 Antigen; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D015804:HLA-DR4 Antigen