title: Effect of kallikrein-kinin system activation by factor XII f pretreatment on experimental hemorrhagic shock.
abstract: Effects of Hageman factor fragment (factor XIIf) administration on shock induction were studied in anesthetized male Wistar rats with hemorrhagic shock. Administration of factor XIIf in non-hemorrhaged rats resulted in an immediate decrease of mean arterial pressure (MAP) for 5 min and in significant increases of blood glucose, lactate and hematocrit (Hct) as well as in a strong tendency for plasma kallikreinogen (KKN) to decrease. At the beginning of bleeding (15 min after factor XIIf administration) MAP has been normalized again. During subsequent hemorrhage pretreated rats showed a sharper decrease in MAP which remained significantly lower up to 25% of estimated blood volume (EBV) and recovered more slowly to normal level after hemorrhage. Blood glucose, lactate and Hct were significantly higher in pretreated animals after hemorrhage of 30% EBV. KKN depicted significant lower values during hemorrhage and in the posthemorrhagic period. Mortality within the observation time increased from 20% (control group) to 60% (pretreated animals). The results demonstrate that prehemorrhagic kallikrein-kinin system (KKS) activation induced an increased severity of shock state with higher mortality.
authors.affiliation: Institute of Pathological Biochemistry, Medical Academy Carl Gustav Carus Dresden, GDR.
authors.forename: M
authors.initials: M
authors.lastname: Taucher
authors.forename: J
authors.initials: J
authors.lastname: Grässler
authors.forename: H
authors.initials: H
authors.lastname: Kühne
authors.forename: D W
authors.initials: DW
authors.lastname: Scheuch
mesh_terms: D000818:Animals; D005174:Factor XII / Q000494:pharmacology*; D007610:Kallikreins / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000209:etiology*
chemical_list: D007705:Kinins; D005174:Factor XII; D007610:Kallikreins