FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
FR109615, a new antibiotic active against Candida, was isolated from Streptomyces setonii No. 7562. Based on the spectroscopic data, the structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid (1). The compound showed the excellent in vivo efficacy in a generalized infection test of mice.
Iwamoto
T
T
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Tsujii
E
E
Ezaki
M
M
Fujie
A
A
Hashimoto
S
S
Okuhara
M
M
Kohsaka
M
M
Imanaka
H
H
Kawabata
K
K
Inamoto
Y
Y
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy; D003515:Cycloleucine / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology / Q000031:analogs & derivatives; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000378:metabolism*
D000935:Antifungal Agents; D003515:Cycloleucine; C065594:cispentacin