Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.
The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lower in stressed rats than in non-stressed rats, suggesting that stress may influence the metabolism and/or excretion of the metabolites.
Gomita
Y
Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Furuno
K
K
Araki
Y
Y
D000818:Animals; D004597:Electroshock; D005528:Foot; D007274:Injections, Intraperitoneal; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D012016:Reference Values; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*
C030398:isosorbide-2-mononitrate; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate