Platelet serotonergic mechanisms in ischaemic heart disease.
The uptake, basal content and efflux of serotonin (5-HT) from the platelets of patients of ischaemic heart disease (I.H.D.) was studied and compared with normal platelets. A significant increase in uptake and basal content of 5-HT as well as increase in 5-HT efflux was observed as compared to control. Our data indicate that I.H.D. is associated with platelet serotonergic dysfunction which seems to indicate that the platelets are preactivated in I.H.D.
Puri
V K
VK
Department of Cardiology, Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Verma
M
M
Saxena
A K
AK
Shanker
K
K
D000787:Angina Pectoris / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D003289:Convalescence; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood; D015539:Platelet Activation; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin