A passive tobacco smoke exposure system for laboratory animals.
A simple passive tobacco smoke exposure system was developed for laboratory animals. The system consisted of a tobacco smoke generator and an exposure chamber. Performance testing was conducted using Fischer 344 rats. The rats were exposed to passive tobacco smoke generated by 20 cigarettes per day for 3 months. The concentration of the cigarette smoke aerosol (particle phase) in the chamber can be kept almost constant during exposure. The daily average mass concentration was 10.0 +/- 4.3 mg/m3 and the carbon monoxide was 79 +/- 22 ppm during exposure.
Tanaka
I
I
Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ishimatsu
S
S
Higashi
T
T
Katoh
T
T
Akiyama
T
T
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001835:Body Weight; D002248:Carbon Monoxide / Q000032:analysis; D004867:Equipment Design; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014028:Tobacco Smoke Pollution / Q000009:adverse effects / Q000032:analysis
D014028:Tobacco Smoke Pollution; D002248:Carbon Monoxide