Tussive effect of a fentanyl bolus administered through a central venous catheter.
One hundred and ten male patients scheduled for coronary artery bypass grafting were allocated randomly into one of three groups. Patients in group A received fentanyl 7 micrograms/kg via a central venous catheter, those in group B were given fentanyl 7 micrograms/kg through a peripheral venous cannula, and patients in group C received sterile water via a central venous catheter. In group A, 45.9% of patients coughed after injection of fentanyl; the mean onset time from the end of fentanyl administration to the beginning of coughing was 10.6 seconds. Only one patient in group B and no patient in the control group exhibited a cough response (p less than 0.0001). We hypothesise that fentanyl can evoke the pulmonary chemoreflex.
Böhrer
H
H
Department of Anaesthesia, University of Heidelberg, West Germany.
Fleischer
F
F
Werning
P
P
D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D003371:Cough / Q000139:chemically induced*; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
D005283:Fentanyl