Effects of orally administered human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
We examined the effects of orally administered human epidermal growth factor (hEGF) on healing of acetic acid-induced gastric ulcers in rats. hEGF, given twice daily at 30 and 100 micrograms/kg for 2 weeks or at 100 micrograms/kg for 4 weeks to rats with ulcers, had no effect on natural healing or the gastric secretion, delayed one caused by indomethacin. Oral hEGF had no effect on basal histamine-stimulated gastric secretion, and stomach weight. These results indicate that oral hEGF has no biological activity on the pathophysiology of the stomach.
Kuwahara
Y
Y
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Sunagawa
Y
Y
Imoto
Y
Y
Okabe
S
S
D000085:Acetates; D000818:Animals; D000897:Anti-Ulcer Agents; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005747:Gastric Fistula / Q000503:physiopathology; D006632:Histamine; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000085:Acetates; D000897:Anti-Ulcer Agents; D004815:Epidermal Growth Factor; D006632:Histamine; D007213:Indomethacin