An unusual presentation of chronic graft-versus-host disease in an unrelated bone marrow transplantation.
The case described is that of an unrelated bone marrow transplantation in a 43-year-old man. Although the major histocompatibility complex met the criteria for a perfect genotypic match, de novo graft-versus-host disease developed with unusual manifestations involving structures of the oral cavity and associated areas. The loss of taste and smell, as well as profound xerostomia, was treated by stimulating salivary flow. Synergistic sialagogues were used with the hope that an increase in salivary production would mediate an improvement in taste and smell.
LeVeque
F G
FG
Harper Hospital, Detroit, Michigan.
D000328:Adult; D000370:Ageusia / Q000209:etiology*; D000781:Anethole Trithione / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D008297:Male; D000857:Olfaction Disorders / Q000209:etiology*; D013651:Taste Disorders / Q000209:etiology*; D014987:Xerostomia / Q000188:drug therapy / Q000209:etiology*
D000781:Anethole Trithione