Mycolyl glycolipids stimulate macrophages to release a chemotactic factor.
We have previously reported that mycolyl glycolipids from Nocardia rubra such as glucose or trehalose mycolates induced granuloma formation in mice. The structure of the carbohydrate moiety of the mycolyl glycolipids influenced the granuloma forming activity profoundly. Here, we have examined the macrophage-chemotactic activity in the culture supernatants stimulated with various glycolipids differing in carbohydrate moiety (trehalose 6,6'-dimycolate, or TDM; glucose monomycolate, or GM; mannose monomycolate, or MM; and fructose monomycolate, or FM). A distinctive chemotactic activity was detected with TDM or GM, but, little or none with MM or FM.
Matsunaga
I
I
Department of Bacteriology, Osaka City University, Japan.
Oka
S
S
Inoue
T
T
Yano
I
I
D000818:Animals; D002630:Chemotactic Factors / Q000378:metabolism*; D003311:Cord Factors / Q000494:pharmacology; D006017:Glycolipids / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009171:Mycolic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D009615:Nocardia / Q000032:analysis
D002630:Chemotactic Factors; D003311:Cord Factors; D006017:Glycolipids; D009171:Mycolic Acids; C048938:glucose mycolate