Partial purification and characterisation of a synovial fluid inhibitor of osteoblasts.
A polypeptide inhibitor of osteoblast proliferation is described which occurs in synovial effusions of patients with rheumatoid arthritis. Partial purification of the inhibitor showed a molecular weight of approximately 81,000 by gel electrophoresis. This polypeptide seems to be unique as no inhibitor of osteoblasts of similar molecular weight has been previously described in rheumatoid synovial effusions.
Hazelton
R A
RA
Department of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.
Vedam
R
R
Masci
P P
PP
Whitaker
A N
AN
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000503:physiopathology*; D002455:Cell Division; D002478:Cells, Cultured; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D008970:Molecular Weight; D010006:Osteoblasts / Q000502:physiology*; D010455:Peptides / Q000302:isolation & purification* / Q000378:metabolism; D013582:Synovial Fluid / Q000032:analysis / Q000378:metabolism / Q000502:physiology*
D010455:Peptides