Somatostatin analog (SMS 201-995) inhibits the basal and angiotensin II-stimulated 3H-thymidine uptake by rat adrenal glands.
The effects of a long-acting somatostatin analog SMS 201-995 injections on the basal and angiotensin II-stimulated [3H]-thymidine uptake by the rat adrenal glands incubated in vitro were examined. It was shown that SMS 201-995 significantly inhibited the [3H]-thymidine uptake and, additionally, suppressed the stimulatory effect of a single angiotensin II injection.
Pawlikowski
M
M
Institute of Endocrinology, Medical Academy of Lódź, Poland.
Lewiński
A
A
Sewerynek
E
E
Szkudliński
M
M
Kunert-Radek
J
J
Wajs
E
E
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D000804:Angiotensin II; D015282:Octreotide; D013936:Thymidine