title: Neurosurgical applications of fibrin glue: augmentation of dural closure in 134 patients.
abstract: In a wide variety of neurosurgical procedures performed on 134 patients over a 3-year period, fibrin glue has been applied as an adjunct to dural closure. Overall success at preventing cerebrospinal fluid (CSF) leakage was 90% (121 of 134, 90% effective). In patients considered to be at high risk for CSF leakage intraoperatively but without pre-established fistulae (Group 1), the success rate was higher (111 of 119, 93% effective). In patients with pre-established CSF fistulae (Group 2), the success rate was lower (10 of 15, 67% effective). As single donor sources of concentrated fibrinogen are now available with reduced risks of blood-borne disease transmission, fibrin glue may be a valuable clinical tool for the neurosurgeon.
authors.affiliation: Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville.
authors.forename: C I
authors.initials: CI
authors.lastname: Shaffrey
authors.forename: W D
authors.initials: WD
authors.lastname: Spotnitz
authors.forename: M E
authors.initials: ME
authors.lastname: Shaffrey
authors.forename: J A
authors.initials: JA
authors.lastname: Jane
mesh_terms: D004388:Dura Mater / Q000601:surgery*; D015718:Fibrin Tissue Adhesive; D006801:Humans; D009493:Neurosurgery / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D015718:Fibrin Tissue Adhesive