Monoclonal antibodies in the treatment of metastatic carcinoma to the liver: report of a pilot study including leukopheresis.
Thirteen patients with metastatic liver carcinoma were treated with hepatic irradiation, leukopheresis and monoclonal antibodies to test the tumoricidal effects of murine 17-1A immunoglobulin G (IgG) Mab. A significant increase in survival for this group of patients was identified.
Amendola
B E
BE
Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania.
Brady
L W
LW
Woo
D
D
Markoe
A M
AM
Miyamoto
C
C
Rackover
M
M
Bulova
S
S
Steplewski
Z
Z
Koprowski
H
H
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007937:Leukapheresis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal