title: Endogenous cholecystokinin reduces feeding in young rats.
abstract: The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.
authors.affiliation: Department of Psychiatry, Cornell University Medical College, White Plains, NY.
authors.forename: A
authors.initials: A
authors.lastname: Weller
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Gibbs
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D020109:Devazepide; D004435:Eating / Q000502:physiology*; D007421:Intestine, Small / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000502:physiology*
chemical_list: D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D020109:Devazepide