Plasma vitamin E and beta-carotene concentrations during radiochemotherapy preceding bone marrow transplantation.
Blood from 19 patients was examined for the essential antioxidants alpha-tocopherol and beta-carotene before, during, and after bone marrow transplantation (BMT). Marrow ablation and immunosuppression for BMT conditioning was achieved by treatment with high-dose chemotherapy, mostly combined with total body irradiation. All patients required total parenteral nutrition beginning 1 wk before BMT. After conditioning therapy the concentration of absolute and lipid-standardized alpha-tocopherol and beta-carotene in plasma decreased significantly, presumably as a result of an enhanced breakdown of these antioxidants. The loss of these lipid-soluble antioxidants has to be considered as a possible cause for early posttransplant organ toxicity.
Clemens
M R
MR
Eberhard-Karls-Universität Tübingen, Medizinische Klinik, FRG.
Ladner
C
C
Ehninger
G
G
Einsele
H
H
Renn
W
W
Bühler
E
E
Waller
H D
HD
Gey
K F
KF
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D016026:Bone Marrow Transplantation; D002338:Carotenoids / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D004910:Erythrocyte Membrane / Q000032:analysis; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D008297:Male; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D009447:Neuroblastoma / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D014810:Vitamin E / Q000097:blood*; D019207:beta Carotene
D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D002784:Cholesterol