Effects of caerulein and cholecystokinin-octapeptide on acetylcholine and choline contents in the brains of intact and vagotomized mice.
The effects of caerulein (CLN; 0.5, 5, and 50 micrograms/kg, IP) and cholecystokinin-octapeptide (CCK-8; 5, 50, and 400 micrograms/kg, IP) on the acetylcholine and choline contents in the discrete brain regions were examined, 30, 60, and 120 min after injection into intact and vagotomized mice. In all of the discrete brain regions of the intact mice. CLN and CCK-8 was found to have a complex effect on the acetylcholine and choline contents depending on the brain region, dosage and treatment time. On the other hand, the effect of CLN was abolished completely in the vagotomized mice. Thus, the present study indicates that peripherally administered CLN and CCK-8 have an effect on the central cholinergic system, mainly mediated via the vagus.
Miyate
H
H
Department of Pharmacology, School of Dentistry, Iwate Medical University, Japan.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology*; D002794:Choline / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009714:Nucleus Accumbens / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology*; D014628:Vagotomy
D002108:Ceruletide; D012844:Sincalide; D002794:Choline; D000109:Acetylcholine