title: Preliminary studies of interstitial hyperthermia using hot water.
abstract: A hot water interstitial hyperthermia unit was used to heat normal tissue in the thighs of rabbits and pigs. A 4 x 4 array of metal needles or plastic tubes spaced at 10 or 14 mm was implanted. Temperature measurements were made using five-sensor thermocouple probes inserted parallel to the implanted needles or tubes. With a water temperature of 48 degrees C, tissue temperature within the implant exceeded 42.5 degrees C when tube spacing was 14 mm and reached 47 degrees C when the spacing was 10 mm. However, at the lower water temperature of 45.5 degrees C inter-tube spacing was more critical, since the tissue temperature was above 43.5 degrees C for a spacing of 10 mm but below 42.5 degrees C for a spacing of 14 mm. Temperatures observed in vivo tended to be higher than those predicted by computer simulations, in which blood flow was assumed to be greater than that of resting muscle i.e. approximately greater than 0.45 kg m-3 s-1. The results show that an interstitial system using hot water can be a simple and efficient method of inducing hyperthermia.
authors.affiliation: University Clinic of Radiotherapy and Radiobiology, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Schreier
authors.forename: M
authors.initials: M
authors.lastname: Budihna
authors.forename: H
authors.initials: H
authors.lastname: Lesnicar
authors.forename: L
authors.initials: L
authors.lastname: Handl-Zeller
authors.forename: J W
authors.initials: JW
authors.lastname: Hand
authors.forename: M V
authors.initials: MV
authors.lastname: Prior
authors.forename: S T
authors.initials: ST
authors.lastname: Clegg
authors.forename: I A
authors.initials: IA
authors.lastname: Brezovich
mesh_terms: D000818:Animals; D001831:Body Temperature; D003198:Computer Simulation; D006358:Hot Temperature / Q000627:therapeutic use*; D008722:Methods; D011817:Rabbits; D012039:Regional Blood Flow; D013552:Swine; D013814:Thermal Conductivity; D014867:Water
chemical_list: D014867:Water