title: Changes in pontine muscarinic receptor binding during sleep-waking states in the rat.
abstract: Number and affinity of pontine muscarinic receptors were examined in rats sacrificed during polygraphically defined wakefulness (W), synchronized sleep (S) and desynchronized sleep (D). Saturation binding assays with (-)-[3H]quinuclidinyl benzilate [( 3H]QNB) showed that muscarinic receptor levels were higher in W and D than in S. These findings indicate that brain receptor levels may change in relation to sleep-waking states. The significance of such changes in relation to the time course of sleep-waking states, as well as the possibility that the number of pontine muscarinic receptors plays a role in the triggering of D are discussed.
authors.affiliation: Istituto di Chimica Biologica, Università di Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pompeiano
authors.forename: G
authors.initials: G
authors.lastname: Tononi
mesh_terms: D000818:Animals; D008297:Male; D011149:Pons / Q000378:metabolism / Q000502:physiology*; D011812:Quinuclidines / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D011812:Quinuclidines; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate