title: Multiple risk factors in hypertension: results from the Gubbio study.
abstract: The association between hypertension and a number of cardiovascular disease risk factors was assessed in the large population sample of Gubbio, a town in central Italy that dates back to medieval times. The data confirm those of previous studies showing that hypertension is strongly associated with other metabolic abnormalities, such as markedly overweight subjects, hyperuricaemia, hyperglycaemia, hypercholesterolaemia, that may be related to the aetiopathogenesis of high blood pressure and, in addition, compound the risk of major clinical cardiovascular events in people with hypertension. The findings are therefore relevant for prevention strategies. In addition, the association between erythrocyte sodium-stimulated lithium countertransport and hypertension is being studied.
authors.affiliation: Centre for Epidemiological Research, Merck Sharp & Dohme, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Laurenzi
authors.forename: M
authors.initials: M
authors.lastname: Mancini
authors.forename: A
authors.initials: A
authors.lastname: Menotti
authors.forename: J
authors.initials: J
authors.lastname: Stamler
authors.forename: R
authors.initials: R
authors.lastname: Stamler
authors.forename: M
authors.initials: M
authors.lastname: Trevisan
authors.forename: A
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D017920:Antiporters; D002352:Carrier Proteins / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000453:epidemiology; D006943:Hyperglycemia / Q000097:blood / Q000150:complications / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D017920:Antiporters; D002352:Carrier Proteins; C045885:sodium-lithium countertransporter; D014527:Uric Acid