title: Tissue response to percutaneous implants in rabbits.
abstract: This study reports on certain aspects of wound-healing around percutaneous implants. Plasma-sprayed and dense hydroxylapatite, titanium, and carbon test implants were inserted into the tibia and the cranium of 12 rabbits. Four and 8 months after insertion, the animals were sacrificed and the implants with their surrounding tissues were processed histologically. Light- and transmission electron microscopic investigations were performed. It is found that direct and indirect bone-anchoring favors the longevity of percutaneous implants. No differences in tissue reaction between the various implant materials were observed.
authors.affiliation: Department of Biomaterials, ACTA-Free University, Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: van der Waerden
authors.forename: H B
authors.initials: HB
authors.lastname: van der Lubbe
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000502:physiology; D002244:Carbon; D003238:Connective Tissue / Q000033:anatomy & histology* / Q000502:physiology; D006882:Hydroxyapatites; D008422:Materials Testing; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D011817:Rabbits; D012867:Skin / Q000033:anatomy & histology*; D012879:Skin Physiological Phenomena; D012886:Skull; D013977:Tibia; D014025:Titanium; D014945:Wound Healing / Q000502:physiology*
chemical_list: D006882:Hydroxyapatites; D002244:Carbon; D014025:Titanium