Prospective evaluation of liver function tests in patients treated with aminoglycosides.
We investigated the relationship between therapy with aminoglycoside antibiotics and alterations in serum liver enzymes and bilirubin. One hundred fourteen patients treated with aminoglycosides and 96 treated with other antibiotics were assessed prospectively during eight days. No elevation in serum alanine aminotransferase, lactic dehydrogenase, or bilirubin was detected in the aminoglycoside and control groups. Alkaline phosphatase increased significantly in the aminoglycoside group (average elevation of 28 +/- 16 units/L on day 6), but no patient had an elevation greater than twice the upper limit of the normal range. We conclude that the abnormality in liver enzymes during aminoglycoside therapy is a mild elevation in alkaline phosphatase, probably with no clinical significance.
Mor
F
F
Department of Internal Medicine B, Beilinson Medical Center, Petah Tiqva, Israel.
Leibovici
L
L
Cohen
O
O
Wysenbeek
A J
AJ
D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000583:Amikacin / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001663:Bilirubin / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D005839:Gentamicins / Q000009:adverse effects; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D004798:Enzymes; D005839:Gentamicins; D000583:Amikacin; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin