An immunohistochemical study of dermatofibrosarcoma protuberans supports its fibroblastic character and contradicts neuroectodermal or histiocytic components.
Paraffin-embedded material from 26 cases of dermatofibrosarcoma protuberans (DFSP) was investigated by the peroxidase-antiperoxidase technique. Antibodies to S-100 protein, Leu-7 antigen, and neuron-specific enolase (neural markers); to lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin (histiocytic markers); and to cytokeratin, desmin, vimentin, and factor VIII were used. The tumor cells reacted only for vimentin. In addition, 12 cases showed positive reactions with histiocytic markers (1-3% of the cells; in two cases, up to 10%). These results support a fibroblastic and contradict a neural or histiocytic histogenesis of DFSP.
Lautier
R
R
Clinic for Dermatology and Venerology, Medical University of Lübeck, F.R.G.
Wolff
H H
HH
Jones
R E
RE
D005347:Fibroblasts / Q000473:pathology; D005354:Fibrosarcoma / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D014746:Vimentin