HLA antigens in Greek patients with cholelithiasis.
The distribution of HLA-A and B antigens was studied in 100 patients with cholelithiasis and in 202 healthy individuals all of Greek origin. An increased frequency of HLA-Aw19 was found in patients (33 per cent) compared with controls (22 per cent) (p less than 0.05, RR 1.7). The increase of Aw19 was even higher for patients with a family history of the disease (44 per cent, vs 22 per cent, p less than 0.01, RR 2.7) and for patients with cholesterol gall stones (44 per cent vs 22 per cent, p less than 0.01, RR 2.5). No difference was seen in patients without a family history of disease or with mixed gall stones. These results suggest a genetic basis for the development of cholesterol gall stone disease.
Papasteriades
C
C
Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece.
al-Mahmoud
I
I
Papageorgakis
N
N
Romania
S
S
Katsas
A
A
Ollier
W
W
Economidou
I
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D002769:Cholelithiasis / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D006115:Greece; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006680:HLA Antigens; D015234:HLA-A Antigens; C043205:HLA-A19 antigen; D002784:Cholesterol