The central medial nucleus: thalamic site of seizure regulation.
This study demonstrates that the central medial intralaminar nucleus (CeM) controls generalized seizure threshold and expression, and that these functions are under gamma-aminobutyric acid (GABA)ergic control, with significant differences between receptor subtypes. Injections of the GABAA-agonist piperidine-4-sulfonic acid and the GABAB-agonist (-)baclofen in the CeM markedly facilitated myoclonic and clonic seizures, but had different effects on tonic seizures. These results are best explained by the concept that the CeM is not a site of seizure origin or spread but rather regulates other structures involved in seizures.
Miller
J W
JW
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110.
Ferrendelli
J A
JA
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline; D004305:Dose-Response Relationship, Drug; D005260:Female; D009118:Muscimol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000503:physiopathology*
D009118:Muscimol; D001418:Baclofen; D001640:Bicuculline