Clinical and histologic effects of extreme intraocular hypothermia.
Rabbit eyes in which vitrectomy was performed underwent three hours of hypothermic perfusion with either 22 C or 2 C lactated Ringer's solution. Clinical, electroretinographic, fluorescein angiographic, histologic, and ultrastructural examinations were performed. No changes were noted in eyes cooled with 22 C fluid. Reversible lens opacities, equivocal electroretinographic changes, and subclinical retinal detachments were found in the eyes cooled with 2 C fluid. Extreme cooling of eyes is not advisable, although temperatures of 22 C are well tolerated.
Zilis
J D
JD
Devers Eye Institute, Portland, Oregon.
Chandler
D
D
Machemer
R
R
D000818:Animals; D002386:Cataract / Q000209:etiology; D003080:Cold Temperature / Q000009:adverse effects; D004596:Electroretinography; D005123:Eye / Q000473:pathology* / Q000503:physiopathology; D005451:Fluorescein Angiography; D007036:Hypothermia, Induced / Q000009:adverse effects; D013508:Ophthalmologic Surgical Procedures; D011817:Rabbits; D012160:Retina / Q000473:pathology / Q000503:physiopathology; D012163:Retinal Detachment / Q000209:etiology; D014821:Vitrectomy