The influence of midazolam on the plasma concentrations of bupivacaine and lidocaine after caudal injection of a mixture of the local anesthetics in children.
Twenty children undergoing surgery received a caudal block using 1 ml per kg of a mixture of 50% lidocaine (1%) and 50% bupivacaine (0.25%). They were randomly allocated to two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration resulted in a significantly lower AUC value for lidocaine but did not influence the plasma concentrations of bupivacaine.
Giaufre
E
E
Surgical Pediatric Department, Saint-Joseph Foundation Hospital, Marseille, France.
Bruguerolle
B
B
Morrison-Lacombe
G
G
Rousset-Rouviere
B
B
D000763:Anesthesia, Caudal; D000767:Anesthesia, Epidural; D000769:Anesthesia, Inhalation; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D011229:Preanesthetic Medication; D011897:Random Allocation; D013997:Time Factors
D004338:Drug Combinations; D008012:Lidocaine; D008874:Midazolam; D002045:Bupivacaine