C3 activation products correlate with antibodies to lipid A in pauciarticular juvenile arthritis.
IgM antibodies to monophosphoryl-lipid A were found to be elevated in sera from children with all forms of juvenile arthritis (JA) and systemic lupus erythematosus. Of more interest, in patients with pauciarticular JA, IgG antibody titers to monophosphoryl-lipid A were found to be correlated with the C3a concentration and the C3d:C3 ratio. Although the full specificity of these antibodies is unknown, they are the first that have been found to be correlated with complement activation products in any form of JA.
Olds
L C
LC
Children's Hospital, Stanford, California 94304.
Miller
J J
JJ
D001171:Arthritis, Juvenile / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis* / Q000276:immunology; D003181:Complement C4 / Q000032:analysis; D003550:Cystic Fibrosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008050:Lipid A / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D012217:Rheumatoid Factor / Q000032:analysis
D001323:Autoantibodies; D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008050:Lipid A; D012217:Rheumatoid Factor