The effect of taurine supplementation on the ototoxicity of neomycin in guinea pigs.
Experiments have been performed to examine the effects of taurine supplementation on the ototoxicity of neomycin. It was found that concurrent administration of taurine and neomycin produced a greater degree of ototoxicity, as evidenced by increases in hearing thresholds, than with neomycin alone. The results are discussed in light of a recently proposed mechanism of aminoglycoside ototoxicity.
Kay
I S
IS
Department of Pharmacology, Medical School, University of Birmingham, England.
Davies
W E
WE
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects*; D001923:Brain Chemistry; D004357:Drug Synergism; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced* / Q000503:physiopathology; D009355:Neomycin / Q000633:toxicity*; D013654:Taurine / Q000032:analysis / Q000633:toxicity*
D013654:Taurine; D009355:Neomycin