title: Anti-class II beta-chain antibodies in the serum and synovial fluid of rheumatoid arthritis patients.
abstract: Sera and synovial fluid (SF) from rheumatoid arthritis (RA) patients were evaluated for anti-HLA class II beta-chain antibodies using single and two-dimensional immunoblots. The antibodies from RA sera and SFs which reacted with class II beta-chain determinants were predominantly IgM and IgA with minimal IgG. This reactivity was also present in SFs from other rheumatic diseases. Anti-class II beta-chain antibodies were also shown to be present simultaneously in RA sera and SF.
authors.affiliation: Division of Biomedical Research, Lovelace Medical Foundation, Albuquerque, New Mexico 87108.
authors.forename: L L
authors.initials: LL
authors.lastname: Marnell
authors.forename: R P
authors.initials: RP
authors.lastname: Searles
authors.forename: S M
authors.initials: SM
authors.lastname: Savage
authors.forename: Y
authors.initials: Y
authors.lastname: Jaramillo
authors.forename: W L
authors.initials: WL
authors.lastname: Sibbitt
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007132:Immunoglobulin Isotypes / Q000032:analysis; D013582:Synovial Fluid / Q000276:immunology
chemical_list: D001323:Autoantibodies; D000949:Histocompatibility Antigens Class II; D007132:Immunoglobulin Isotypes