title: [Enhancing factors in the cardiotoxicity of anthracyclines].
abstract: We have studied 60 pediatric patients with different neoplastic diseases, treated with anthracyclines. We have followed them clinically and echocardiographically to detect the cardiotoxicity due to anthracyclines and the enhanced factors promptly. We have detected a more important incidence of cardiomyopathy in patients with non-Hodgkin's lymphoma, osteosarcoma and neuroblastoma despite cumulative doses under 550 mg/m2 of anthracyclines. The 2 first groups were treated with high doses of cyclophosphamide and methotrexate, and neuroblastomas with melphalan. The anthracyclines cardiotoxicity is evaluated around 5% in patients treated with doses under 550 mg/m2, and is increased in case of previous or simultaneous aggressive therapy. Continued echocardiography enables a premature detection of cardiotoxicity in these high risk patients.
authors.affiliation: Servicio de Oncología Pediátrica, Hospital Infantil Valle de Hebrón, Universidad Autónoma de Barcelona.
authors.forename: N
authors.initials: N
authors.lastname: Sanz Manrique
authors.forename: J
authors.initials: J
authors.lastname: Valcarce Pérez
authors.forename: P
authors.initials: P
authors.lastname: Broto Escapa
authors.forename: J
authors.initials: J
authors.lastname: Escribano Subías
authors.forename: J
authors.initials: J
authors.lastname: Casaldáliga Ferrer
authors.forename: F A
authors.initials: FA
authors.lastname: Moraga Llop
authors.forename: J
authors.initials: J
authors.lastname: Sánchez de Toledo Codina
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D004357:Drug Synergism; D004452:Echocardiography; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008558:Melphalan / Q000009:adverse effects / Q000627:therapeutic use; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D003520:Cyclophosphamide; D008558:Melphalan; D008727:Methotrexate
vernacular_title: Factores coadyuvantes de la toxicidad cardiaca por antraciclínicos.