Differential effects of central and peripheral cholinergic blockade on water consumption by rats.
Atropine (5 mg/kg, s.c., twice daily) had no significant effect on 24-h water consumption on day 1 of treatment; on subsequent days the rats showed a significant increase. Procyclidine (5 mg/kg, s.c., twice daily) had a similar effect, except that the increase in daily water consumption began on the third day of treatment. Methylatropine (5 mg/kg, s.c., twice daily) markedly depressed water consumption on day 1; from the second day on no significant effects on 24-h water consumption were seen. The results suggest that the dipsogenic actions of cholinergic blocking agents on 24-h water consumption involve central rather than purely peripheral actions.
Alharbi
M M
MM
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
Maickel
R P
RP
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001286:Atropine Derivatives / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011352:Procyclidine / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001286:Atropine Derivatives; D010276:Parasympatholytics; D011759:Pyrrolidines; D001285:Atropine; C006649:methylatropine; D011352:Procyclidine