title: Mitochondrial encephalomyopathy (MELAS) with mental disorder. CT, MRI and SPECT findings.
abstract: A case of mitochondrial encephalomyopathy (MELAS) with mental disorder is reported. The SPECT study using 123I-iodoamphetamine (IMP) and MRI study revealed abnormality in the left parieto-occipital areas without abnormality in the brain CT or brain scintigram. These findings suggest a localized dysfunction of the brain capillary endothelium in association with the cerebral involvement of mitochondrial encephalomyopathy.
authors.affiliation: Department of Psychiatry, University of Tsukuba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Koizumi
authors.forename: H
authors.initials: H
authors.lastname: Shiraishi
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Ofuku
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: N
authors.initials: N
authors.lastname: Ohkoshi
authors.forename: I
authors.initials: I
authors.lastname: Anno
mesh_terms: D000140:Acidosis, Lactic / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008931:Mitochondria, Muscle / Q000473:pathology*; D011877:Radionuclide Imaging; D013577:Syndrome; D014057:Tomography, X-Ray Computed