title: Intraocular pressure and iris denervation in Hansen's disease.
abstract: We retrospectively analyzed 255 Hansen's disease patients and found low intraocular pressure (less than 7 mm Hg) in 12% of them. We showed a correlation between low intraocular pressure and avascular keratitis and iritis. We also found that patients with low intraocular pressures had abnormally large postural changes in intraocular pressure. We speculate that abnormalities in the autonomic innervation of the anterior segment of the eye may be related to the intraocular pressure abnormalities. Further investigations along this line may increase our understanding not only of the pathophysiology of Hansen's disease but also of the mechanisms regulating homeostasis of intraocular pressure.
authors.affiliation: Francis I. Proctor Foundation, University of California, San Francisco 94143-0412.
authors.forename: S
authors.initials: S
authors.lastname: Lewallen
authors.forename: N
authors.initials: N
authors.lastname: Hussein
authors.forename: P
authors.initials: P
authors.lastname: Courtright
authors.forename: H B
authors.initials: HB
authors.lastname: Ostler
authors.forename: R H
authors.initials: RH
authors.lastname: Gelber
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D016022:Case-Control Studies; D006706:Homeostasis; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000294:innervation*; D007918:Leprosy / Q000503:physiopathology*; D009410:Nerve Degeneration; D011187:Posture; D011680:Pupil / Q000187:drug effects; D012189:Retrospective Studies; D010136:p-Hydroxyamphetamine
chemical_list: D010136:p-Hydroxyamphetamine