Chemoprotection of garlic extract toward cyclophosphamide toxicity in mice.
The effect of the administration of an extract of garlic (Allium sativum) was studied in mice that were treated with a chronic lethal dose of cyclophosphamide (50 mg/kg body wt, 14 days). The intraperitoneal administration of garlic (50 mg/animal, 14 days) along with cyclophosphamide reduced the toxicity of the latter considerably with an increase in life span of more than 70%. The administration of garlic extract did not improve the lymphopenia produced by cyclophosphamide or liver alkaline phosphatase, but there was a significant reduction in liver glutamic-pyruvic transaminase. Moreover, garlic extract reduced the level of lipid peroxidation induced in the liver by cyclophosphamide administration. Administration of garlic extract did not interfere with the tumor-reducing activity of cyclophosphamide.
Unnikrishnan
M C
MC
Amala Cancer Research Centre, Kerala, India.
Soudamini
K K
KK
Kuttan
R
R
D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005737:Garlic; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
D006454:Hemoglobins; D008054:Lipid Peroxides; D010936:Plant Extracts; D003520:Cyclophosphamide; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase