Feasibility of transposition of the ovaries in the surgical and radiotherapeutical treatment of cervical cancer.
Ovaries are seldom subject to metastases and therefore their preservation is possible in radical cervical cancer surgery. However, with postoperative radiotherapy they cannot be preserved unless they are placed outside the radiation field. The practicality of this transposition was analysed in a series of 126 patients with cervical cancer. The ovaries were transposed intraperitoneally in a lateral and cranial direction in 44 of the 64 women under the age of 50 years. In 16 of these 44 women, only one ovary could be preserved and transposed. A critical analysis was performed of the ovaries' new location by plotting their position, marked by 2 clips each, in a single pelvis. In 68% of the women at least one ovary was placed outside the radiation field. However, because of scattered radiation, i.e. 5% of the total radiation dose at a distance of 4 cm outside the radiation field, a substantial loss of ovarian function may occur. In 32% of the women at least one ovary received less than this 5%. Optimal transposition may be achieved after extension of the abdominal incision. However, this will be unnecessary in most cases, since postoperative radiotherapy will be indicated in only approximately 15% of the women.
van Beurden
M
M
Department of Obstetrics and Gynecology, University of Amsterdam, The Netherlands.
Schuster-Uitterhoeve
A L
AL
Lammes
F B
FB
D000328:Adult; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008594:Menopause, Premature / Q000528:radiation effects; D008875:Middle Aged; D010053:Ovary / Q000528:radiation effects / Q000601:surgery*; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy / Q000601:surgery*