Construction of best confidence intervals for half-lives.
This paper presents a method of determining a confidence interval for the drug half-life based on statistical properties of the estimates of the disappearance rate constant of the drug. This interval is shown to be of minimum length which indicates it is a more precise estimate than others currently in use. A computer program to construct these intervals is available upon request.
Bartoszyński
R
R
Department of Statistics, Ohio State University, Columbus 43210.
Powers
J D
JD
D016001:Confidence Intervals; D006207:Half-Life; D010599:Pharmacokinetics; D013223:Statistics as Topic