title: Treatment of dairy cows with recombinant bovine somatotropin: genetic and phenotypic aspects.
abstract: Thirty-four multiparous and primiparous Holstein cows were utilized to examine the association between the response to long-term administration of recombinant bovine somatotropin and the cow's phenotypic and genetic production potential. Cows representing a range of phenotypic and genetic production potentials were assigned to one of four treatment groups: 0, 12.5, 25.0, or 50.0 mg recombinant bovine somatotropin daily. They were injected daily for 266 d beginning on d 24 to 35 postpartum. Pretreatment milk and fat yields were used to predict daily yields over the lactation and allowed treatment groups to serve as their own controls. Actual minus predicted yield estimated the response to treatment for milk, fat, and FCM for each cow. Milk composition (fat, protein, and lactose percentage) was not significantly affected by treatment. Response in yield for milk, fat, and FCM was significant during the treatment period (266 d). Milk yield increased by 18.5, 19.9, and 21.4%; fat yield increased by 13.4, 20.3, and 18.1%; and FCM increased by 16.3%, 19.7%, and 21.1% after receipt of 12.5, 25.0 and 50.0 mg recombinant bovine somatotropin, respectively. Differences in response were not significant. The dramatic effect recombinant bovine somatotropin has on production requires that alternative approaches be adopted in the future for accurate genetic evaluation of sires and dams if somatotropin is discriminantly used in the national herd.
authors.affiliation: Animal Science Department, University of Guelph, Ontario.
authors.forename: H W
authors.initials: HW
authors.lastname: Leitch
authors.forename: E B
authors.initials: EB
authors.lastname: Burnside
authors.forename: B W
authors.initials: BW
authors.lastname: McBride
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects* / Q000235:genetics; D016018:Least-Squares Analysis; D008892:Milk / Q000032:analysis / Q000187:drug effects; D010641:Phenotype; D011247:Pregnancy; D011994:Recombinant Proteins / Q000494:pharmacology; D012044:Regression Analysis
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone