The anticoagulant effect of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-6-hydroxyhexylamine, another amino-estrogen with prolonged anticoagulant effect.
The anticoagulant and estrogenic effects of hexolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-6-hydroxyhexylamine, are described. A single subcutaneous injection of hexolame in adult and infant male mice produced dose-dependent increases in blood clotting time which could be observed even after 2 days. In ovariectomized mice, hexolame produced vaginal cornification (estrogenic response). The data suggested that if used in the treatment of prostatic cancer, hexolame, like prolame, would not induce cardiovascular accidents. It could also be useful in the prevention of thrombosis.
Rubio-Póo
C
C
Sección de Farmacología, ENEP-Zaragoza, México.
Lemini
C
C
García-Mondragón
J
J
de la Peña
A
A
Jayme
V
V
Mendoza-Patiño
N
N
Zavala
E
E
Silva
G
G
Blickenstaff
R T
RT
Fernández
J M
JM
D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D000925:Anticoagulants; D004305:Dose-Response Relationship, Drug; D004963:Estrenes / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D013927:Thrombosis / Q000517:prevention & control; D014623:Vaginal Diseases / Q000188:drug therapy; D014914:Whole Blood Coagulation Time
D000605:Amino Alcohols; D000925:Anticoagulants; D004963:Estrenes; D004967:Estrogens; C063632:hexolame