title: Electrically silent anion transport through bilayer lipid membrane induced by tributyltin and triethyllead.
abstract: The method of the measurement of the nonelectrogenic fluxes of hydrogen (or hydroxyl) ions (JH) based on the local proton gradients formation in the unstirred layers near a bilayer lipid membrane (BLM) is applied for recording the nonelectrogenic anion/OH- exchange on BLM induced by tributyltin (TBT) and a novel carrier (Hager, A., Moser, I., & Berthold, W. 1987. Z. Naturforsch., 42C:1116-1120), triethyllead (TEL). This method has been used previously for measuring the cation fluxes through BLM. TBT and TEL are shown to be equally efficient in the induction of Cl-/OH- exchange. JH induced by TBT is constant at 4 less than pH less than 7. JH decreases at pH less than 4 and pH greater than 7. Both ionophores have a transport sequence: I- greater than Br- greater than Cl- greater than F-. The quantitative measurements reveal that TEL better discriminates these four anions than TBT. It is concluded that this method may prove helpful in a search and study of anion/OH(-)-exchangers isolated from natural membranes.
authors.affiliation: A.N. Belozersky Laboratory, Moscow State University, USSR.
authors.lastname: Antonenko YuN
mesh_terms: D000838:Anions / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D009942:Organometallic Compounds / Q000494:pharmacology*; D014220:Trialkyltin Compounds / Q000494:pharmacology*
chemical_list: D000838:Anions; D008051:Lipid Bilayers; D009942:Organometallic Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C010360:triethyllead