title: Inhibitory effects of benomyl and carbendazim on the [3H]thymidine incorporation in various organs of the mouse--evidence for a more pronounced action of benomyl.
abstract: The benzimidazole fungicides benomyl and carbendazim were compared with regard to effects on [3H]thymidine incorporation in various organs of male mice given the compounds orally at various time intervals before sacrifice. Since carbendazim is a major metabolite of benomyl, it is generally assumed that the fungicidal action and toxicity of these compounds are due to the action of carbendazim. However, whereas benomyl inhibited the [3H]thymidine incorporation into thymus, spleen, liver, kidney and testis, an equimolar amount (3.4 mmol/kg body wt) of carbendazim induced a similar effect only in testis.
authors.affiliation: Department of Toxicology, Uppsala university, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hellman
authors.forename: D
authors.initials: D
authors.lastname: Laryea
mesh_terms: D000818:Animals; D001542:Benomyl / Q000633:toxicity*; D001562:Benzimidazoles / Q000633:toxicity*; D002219:Carbamates / Q000633:toxicity*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; D004247:DNA; C006698:carbendazim; D001542:Benomyl; D013936:Thymidine