Urinary thromboxane B2 and 2,3-dinor-thromboxane B2 in the neonate born at full-term age.
We have developed a method for measurement of urinary 2,3-dinor-TXB2, which is a reflection of the actual rate of TXA2 synthesis by platelets in vivo. This determination was based on purification by high-pressure liquid chromatography and on measurement by RIA. After validation of the assay, we established the range of urinary Tx metabolites in healthy infants born at full-term during their first week of life. The 2,3-dinor-TXB2 levels were higher than in adults and declined gradually during the first seven days of life.
Van Geet
C
C
Center for thrombosis and Vascular Research, Gasthuisberg, K.U. Leuven, Leuven, Belgium.
Arnout
J
J
Eggermont
E
E
Vermylen
J
J
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D008297:Male; D009994:Osmolar Concentration; D011863:Radioimmunoassay; D012016:Reference Values; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000652:urine*; D014316:Tritium
D014316:Tritium; D013929:Thromboxane B2; C028965:2,3-dinor-thromboxane B2