Hypoperfusion of the small intestine during slow infusion of a low dosage of endotoxin in anesthetized horses.
The effects of intravenous infusion of endotoxin for 30 minutes at a cumulative dosage of 0.03 micrograms/kg on average carotid arterial pressure, and on average arterial pressure, capillary pressure, venous pressure, total vascular resistance, precapillary resistance, postcapillary resistance, and capillary filtration coefficient in the jejunum were compared to the effects of intravenous infusion of 0.9% sodium chloride solution in 6 anesthetized horses. Endotoxin significantly reduced intestinal venous blood flow by inducing vasoconstriction. Increased vascular resistance resulted from increased precapillary resistance. The capillary filtration coefficient was unchanged by endotoxin. These results suggest that intestinal vasoconstriction occurs during the compensatory stages of endotoxemia.
Clark
E S
ES
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens.
Collatos
C
C
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002200:Capillary Resistance / Q000187:drug effects*; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D006734:Horse Diseases / Q000209:etiology*; D006736:Horses; D007262:Infusions, Intravenous / Q000662:veterinary; D007583:Jejunum / Q000098:blood supply*; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
D004731:Endotoxins