DNA autosensitivity in two Japanese sisters.
Two cases of DNA autosensitivity in Japanese sisters are reported. Both patients developed painful ecchymoses and other bleeding disorders. Skin tests with autologous leukocyte lysates and calf thymus DNA produced intermediate-type reactions that were identical to spontaneous skin reactions. Pretreatment of DNA with either DNase or chloroquine sulfate inhibited these reactions. Our studies suggest that anti-DNA antibodies might contribute to the clinical symptoms of this disorder.
Sugai
S
S
Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.
Yasuda
Y
Y
Shimizu
S
S
Sawada
M
M
Tachibana
J
J
Konda
S
S
Kitada
H
H
Nakaizumi
H
H
Tsukada
S
S
D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D002417:Cattle; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use; D004247:DNA / Q000187:drug effects / Q000276:immunology*; D003851:Deoxyribonucleases / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007564:Japan; D008775:Methylprednisolone / Q000627:therapeutic use; D012882:Skin Tests
D001323:Autoantibodies; D002738:Chloroquine; D004247:DNA; D003851:Deoxyribonucleases; D008775:Methylprednisolone