The effect of hemodialysis on omeprazole plasma concentrations in the anuric patient: a case report.
Omeprazole, a drug suppressing gastric acidity secretion was given intravenously at a dose of 40 mg/day to an anuric patient. Pharmacokinetics data indicate that without hemodialysis treatment, the dose can be reduced by 40% without any danger of loss of effectiveness. During hemodialysis however, the full dose must be given. Controlled long-term studies will be required to determine the exact dose for continued treatment.
Roggo
A
A
Division of Gastroenterology and Nephrology, Medical Department of Kantonsspital, Lucerne, Switzerland.
Filippini
L
L
Colombi
A
A
D000328:Adult; D001002:Anuria / Q000628:therapy*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006435:Renal Dialysis
D009853:Omeprazole