Genetic-epidemiologic study of haemophilia A and B in Hungary.
All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western countries of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10,000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10(-5) for haemophilia A and 0.2 x 10(-5) for haemophilia B.
István
L
L
Department of Blood Transfusion, Markusovszky Hospital of County Vas, Szombathely.
Czeizel
A
A
Kerényi
M
M
Tóth
A M
AM
Domby
E
E
D005193:Family Planning Services / Q000706:statistics & numerical data*; D006580:Genetic Carrier Screening; D005828:Genetics, Population; D006467:Hemophilia A / Q000453:epidemiology* / Q000235:genetics; D002836:Hemophilia B / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D009154:Mutation; D015995:Prevalence