title: Wavefront propagation in an activation model of the anisotropic cardiac tissue: asymptotic analysis and numerical simulations.
abstract: In this paper we present a macroscopic model of the excitation process in the myocardium. The composite and anisotropic structure of the cardiac tissue is represented by a bidomain, i.e. a set of two coupled anisotropic media. The model is characterized by a non linear system of two partial differential equations of parabolic and elliptic type. A singular perturbation analysis is carried out to investigate the cardiac potential field and the structure of the moving excitation wavefront. As a consequence the cardiac current sources are approximated by an oblique dipole layer structure and the motion of the wavefront is described by eikonal equations. Finally numerical simulations are carried out in order to analyze some complex phenomena related to the spreading of the wavefront, like the front-front or front-wall collision. The results yielded by the excitation model and the eikonal equations are compared.
authors.affiliation: Istituto di Analisi Numerica del C.N.R., Corso C. Alberto 5, Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Colli Franzone
authors.forename: L
authors.initials: L
authors.lastname: Guerri
authors.forename: S
authors.initials: S
authors.lastname: Rovida
mesh_terms: D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008954:Models, Biological