Differences between responsive and intractable chronic lymphocytic leukemia.
About 19-26% of patients with chronic lymphocytic leukemia (CLL) have intractable disease resistant to chemotherapy, have a relatively short median survival time and are responsive to splenectomy. Lymphocytes from patients with intractable CLL are resistant in vitro to X-irradiation and to colchicine. Responsive CLL is an accumulative disease while intractable CLL is a proliferative disease.
Schrek
R
R
Research Service, VA Hospital, Hines, IL 60141.
D003078:Colchicine; D003937:Diagnosis, Differential; D004351:Drug Resistance; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification* / Q000209:etiology / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D011836:Radiation Tolerance; D012074:Remission Induction
D003078:Colchicine