Targeted delivery of low dose doxorubicin hydrochloride administered via magnetic albumin microspheres in rats.
The efficacy of magnetic albumin microspheres in the targeted delivery of an anti-cancer agent, doxorubicin hydrochloride, has been investigated in rats. Using the tail as a target organ, the animals were intra-arterially administered with either 0.12 mg/kg of free drug, or 0.04 mg/kg of microsphere entrapped drug in the presence of a 8000 Gauss magnet applied for 30 min at the target-site. In each group, the animals were sacrificed over a 48 h period and their various tissues analysed for drug concentration using HPLC. It was found that compared to the free drug, a one-third dose of microsphere entrapped drug resulted in almost eight times higher drug exposure (AUC0-infinity) at the target site. In addition, the drug delivery to all the non-target tissues, including liver and heart, was substantially reduced. The study confirms the efficacy of magnetic albumin microspheres in the targeted delivery of chemotherapeutic agents.
Gupta
P K
PK
Department of Pharmacy, University of Otago, Dunedin, New Zealand.
Hung
C T
CT
D000418:Albumins; D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D005260:Female; D008280:Magnetics; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains
D000418:Albumins; D004337:Drug Carriers; D004317:Doxorubicin