Effect of N alpha-benzoyl-L-arginine ethyl ester on coronary perfusion pressure in isolated guinea pig heart.
N alpha-Benzoyl-L-arginine ethyl ester (BAEE) when compared to L-arginine significantly decreased coronary perfusion pressure of isolated guinea pig heart in a dose dependent and reproducible manner. This effect of BAEE was antagonized by haemoglobin and N-monomethyl L-arginine, both inhibitors of endothelium dependent relaxation. These results support the notion that the mechanism of relaxation elicited by BAEE is due to the generation endothelium dependent relaxing factor (EDRF) like agents.
Thomas
G
G
Georgetown University Medical Center, Department of Physiology, Washington, DC 20007.
Farhat
M
M
Myers
A K
AK
Ramwell
P W
PW
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006454:Hemoglobins / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D019323:omega-N-Methylarginine
D006454:Hemoglobins; D019323:omega-N-Methylarginine; D001120:Arginine; C012208:benzoyl L-arginine methyl ester; C009727:benzoylarginine ethyl ester