Microbiological patterns of four new imidazole derivatives.
The authors present an in vitro experimental study concerning the microbiological properties of four imidazole derivatives, with a piperazine group between two benzene rings. Seventy strains of Gram-positive and Gram-negative bacteria, 30 of yeasts, 14 of filamentous fungi and 10 strains of Trichomonas vaginalis were tested. The new compounds revealed a good inhibitory activity against Gram-positive bacteria, yeasts and dermatophytes. These results compare well with those obtained with the other known imidazoles. Moreover any mutagenic activity is absent.
Dubini
F
F
Institute of Medical Microbiology, Milan University, Italy.
Riviera
L
L
Bellotti
M G
MG
Mattina
R
R
Bignami
P
P
Stradi
R
R
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009153:Mutagens; D014244:Trichomonas / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007093:Imidazoles; D009153:Mutagens