Hyaluronic acid promotes chick embryo fibroblast and chondroblast expression.
15-day-chick-embryo fibroblasts and chondroblasts were cultured in the presence of high and low molecular weight exogenous hyaluronic acid (HA). Growth range and incorporation of radiolabelled sulphate and proline were determined. HA reduced cell proliferation to about 75% of controls, while incorporation of radiolabelled sulphate and proline was higher in HA-treated cultures of both chondroblasts and fibroblasts. The effect was not due to the polyanionic or polymeric nature of the molecule and appeared to be highly specific for HA.
Cortivo
R
R
Institute of Histology and Embryology, University of Padua, Italy.
De Galateo
A
A
Castellani
I
I
Brun
P
P
Giro
M G
MG
Abatangelo
G
G
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003094:Collagen; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005353:Fibronectins; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008970:Molecular Weight; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis; D013431:Sulfates / Q000378:metabolism; D014316:Tritium
D005353:Fibronectins; D013431:Sulfates; D014316:Tritium; D006820:Hyaluronic Acid; D003094:Collagen; D011392:Proline