Apomorphine-induced motor behavior in rats exposed prenatally to alcohol.
We psychopharmacologically examined dopamine function in rats exposed to ethanol prenatally. Pregnant rats received liquid diets of 35% or 0% ethanol-derived calories (EDC), or ad lib lab chow (LC). Twenty-eight-day-old offspring received systemic doses of apomorphine chosen to stimulate predominantly presynaptic (0.02 or 0.1 mg/kg) or postsynaptic dopamine receptors (2.0 or 5.0 mg/kg). Behavior was scored automatically for 60 min in an "open field." For males, prenatal ethanol exposure resulted in a dose-response shift to the left for locomotor activity. Females exposed to the liquid diet, with or without ethanol, showed less of an increase in locomotor activity following the 5.0 mg/kg dose of apomorphine than did LC controls. There were no effects of prenatal treatment on repetitious motor behavior in the automated "open field" or on stereotypy scored by direct observation in separate groups of rats. The results are consistent with an hypothesis that prenatal ethanol exposure alters the sensitivity of postsynaptic (perhaps mesolimbic) dopamine systems important to locomotor activity in young male rats.
Hannigan
J H
JH
Center for Behavioral Teratology, The University at Albany, NY 12222.
Blanchard
B A
BA
Horner
M P
MP
Riley
E P
EP
Pilati
M L
ML
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004298:Dopamine / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects
D001058:Apomorphine; D004298:Dopamine