Intracellular stability of the gene encoding influenza virus haemagglutinin.
The intracellular stability of the genome of noninfectious uv-irradiated influenza virus (A/WSN:H1N1) in dividing MDCK cells was investigated using marker rescue techniques. The haemagglutinin gene could still be rescued by infection with A/X49 (H3N2) at 5 weeks postinoculation; its half-life was 13 days.
Cane
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Department of Biological Sciences, University of Warwick, Coventry, United Kingdom.
Dimmock
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NJ
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D005819:Genetic Markers; D006207:Half-Life; D006389:Hemagglutinins, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000235:genetics* / Q000254:growth & development; D014158:Transcription, Genetic; D010948:Viral Plaque Assay; D014779:Virus Replication
D005819:Genetic Markers; D006389:Hemagglutinins, Viral