Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions.
The levels of soluble IL-2R were measured in pleural fluid from patients with tuberculosis pleurisy. There were significantly elevated soluble IL-2R values in tuberculous pleural fluid as compared with pleural fluid of nontuberculous etiology including malignant, bacterial and transudative pleural effusions. In patients with tuberculous pleurisy, the level of soluble IL-2R in pleural fluid was markedly greater than that in serum. Furthermore, a significant positive correlation was observed between soluble IL-2R levels and adenosine deaminase levels in tuberculous pleural fluid. These findings suggest that elevated levels of pleural fluid soluble IL-2R in tuberculous pleurisy could reflect the local proliferation of activated T-cells and may be clinically useful in the diagnostic procedures for patients with pleural tuberculosis.
Ito
M
M
Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan.
Kojiro
N
N
Shirasaka
T
T
Moriwaki
Y
Y
Tachibana
I
I
Kokubu
T
T
D000243:Adenosine Deaminase / Q000032:analysis; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology; D014396:Tuberculosis, Pleural / Q000378:metabolism*
D015375:Receptors, Interleukin-2; D000243:Adenosine Deaminase