Aluminum-induced microcytosis in a child with moderate renal insufficiency.
A child with moderate renal failure, on high doses of aluminum compounds for treatment for hyperphosphatasemia, presented with unexplained microcytosis. The patient also had psychomotor delay. On discontinuation of aluminum, microcytosis reversed in 2 months. Four months later, psychomotor development improved. Children with renal failure, on aluminum supplementation, should be carefully monitored for toxicity. Microcytosis may be a clue to aluminum toxicity in such patients.
Shah
N R
NR
Department of Pediatric Subspecialty, Geisinger Medical Center, Danville, Pennsylvania 17822.
Oberkircher
O R
OR
Lobel
J S
JS
D000536:Aluminum Hydroxide / Q000009:adverse effects*; D000740:Anemia / Q000097:blood / Q000139:chemically induced*; D002675:Child, Preschool; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D010758:Phosphorus / Q000097:blood
C025173:basic aluminum carbonate gel; D010758:Phosphorus; D000536:Aluminum Hydroxide