Pivampicillin versus doxycycline in the treatment of chlamydial urethritis in men.
Pivampicillin and doxycycline were compared in the treatment of chlamydial urethritis in 80 heterosexual men. The trial was carried out in a double-blind, comparative parallel group fashion. Forty patients were treated with 700 mg of pivampicillin twice daily and another 40 with 200 mg of doxycycline on the first day and thereafter with 100 mg of doxycycline and one placebo tablet daily. Both treatments lasted for 9 days. Follow-up examinations were carried out 2 weeks (14-16 days) and 4 weeks (26-30 days) after the start of treatment. Altogether five (12.5%) of the forty pivampicillin-treated patients were clinical failures and three (7.5%) still harbored Chlamydia trachomatis after treatment. The corresponding figures for the doxycycline-treated patients were two (5.1%) and one (2.6%). The difference between the treatment results of the two groups did not reach statistical significance.
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AB
Out-Patient Department of Venereal Diseases, University Central Hospital, Helsinki, Finland.
Virrankoski
T
T
Reitamo
S J
SJ
Kartamaa
M
M
Happonen
H P
HP
Saikku
P A
PA
Karvonen
P K
PK
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JE
D000667:Ampicillin / Q000031:analogs & derivatives*; D002690:Chlamydia Infections / Q000188:drug therapy*; D004311:Double-Blind Method; D004318:Doxycycline / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010917:Pivampicillin / Q000627:therapeutic use*; D012107:Research Design; D014526:Urethritis / Q000188:drug therapy*
D010917:Pivampicillin; D000667:Ampicillin; D004318:Doxycycline