title: [Disturbance of the autonomic nerve system in patients with chronic renal failure--represented by variation coefficient of R-R intervals in the ECG as a parameter].
abstract: Autonomic nerve dysfunction in patients with chronic renal failure has of late become an issue to be investigated. R-R intervals in resting electrocardiograms were measured to evaluate activities of the cardiac parasympathetic nerve system. A total of 140 patients with chronic renal failure were studied to be compared with 20 normal controls (cont.) and 39 with diabetes mellitus (DM). Of these patients 15 were subjected to conservative treatment (CRF), while 125 patients were undergoing hemodialysis due to chronic renal failure-100 of them derived from chronic glomerulonephritis (HD) and 25 from diabetes mellitus (DM.HD). The variation coefficient of the R-R interval (CVRR) was measured after the subject patients had rested for over 15 minutes before a dialysis session. The mean CVRR were 2.15 +/- 1.25% in CRF group, 2.36 +/- 1.37% in HD and 1.37 +/- 0.99% in DM.HD. These values were significantly lower than in control group (4.70 +/- 2.64%). On the other hand, the value in DM.HD group, as shown above, was significantly lower than in HD. In CRF group the CVRR values lowered as residual renal functions decreased. No significant correlations between CVRR S and the duration of hemodialysis treatment were noted among the groups. In HD group the CVRR S were significantly lower in patients with hypotensive tendency during hemodialysis than in those who enjoyed good control of blood pressure. These results suggest that the measurement of CVRR S can be of help in evaluating autonomic nerve dysfunction in patients with chronic renal failure.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
authors.forename: K
authors.initials: K
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Nagayama
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsubo
authors.forename: T
authors.initials: T
authors.lastname: Ohashi
authors.forename: R
authors.initials: R
authors.lastname: Hagihara
authors.forename: K
authors.initials: K
authors.lastname: Uomizu
authors.forename: W
authors.initials: W
authors.lastname: Yamashita
authors.forename: A
authors.initials: A
authors.lastname: Nakashima
authors.forename: R
authors.initials: R
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000503:physiopathology*