title: Cytogenetics of carcinoma in situ of the testis.
abstract: Carcinoma in situ (CIS) of the testis is the precursor lesion of most testicular germ cell tumors (TGCTs). Karyotyping of CIS is important for a better understanding of the pathogenesis of TGCTs and the progression to invasive cancer. We karyotyped three cases of CIS. All three cases showed a numerical abnormal chromosomal pattern. In one case, two copies of the germ cell tumor marker i(12p) were found.
authors.affiliation: Department of Medical Genetics, State University of Groningen, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Vos
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: B
authors.initials: B
authors.lastname: de Jong
authors.forename: J
authors.initials: J
authors.lastname: Buist
authors.forename: H
authors.initials: H
authors.lastname: Schraffordt Koops
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008297:Male; D009361:Neoplasm Invasiveness; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor