[Dose intensity and clinical response in patients with advanced gastric carcinoma treated by induced hypertension chemotherapy].
Dose Intensity (DI) was analyzed among 52 eligible and complete patients with advanced gastric carcinoma receiving ADM, 5-FU & MMC (AFM) combination regimen under angiotensin II Induced Hypertension Chemotherapy (IHC). In the induction period DI of CR either in the initial response time or in the effective tumor reduction time was smaller than that of PR, although DI of total period of AFM administration was not different. Based on the evidences, heterogeneous distribution in tumor blood flow under normotension got improved under hypertension by angiotensin II, and chemotherapeutic effects were enhanced. A possibility of the reduction of doses of the drugs administered was suggested. In the maintenance, based on the clinical results, it is mentioned that DI is also useful for an indicator to decide the doses and continuation periods of drugs to be administered. Further investigation on DI will lead to obtain much better maneuver of chemotherapy.
Sato
H
H
Dept. Clinical Cancer Chemotherapy, Tohoku University.
Urushiyama
M
M
Sugiyama
K
K
Ishizuka
K
K
Hoshi
M
M
Wakui
A
A
D000804:Angiotensin II / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D008937:Mitomycins; D000804:Angiotensin II; D016685:Mitomycin; D004317:Doxorubicin; D005472:Fluorouracil