5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulated during AMI treatment.
Lesch
K P
KP
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Disselkamp-Tietze
J
J
Schmidtke
A
A
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000378:metabolism*
D011743:Pyrimidines; D011985:Receptors, Serotonin; D000639:Amitriptyline; C043077:ipsapirone