Effects of plasmapheresis on familial type III hyperlipoproteinemia associated with glomerular lipidosis, nephrotic syndrome and diabetes mellitus.
A 59-year-old woman, one of 5 cases with familial type III hyperlipoproteinemia reported at our clinic to date, had nephrotic syndrome and diabetes mellitus, but had neither coronary atherosclerosis nor xanthoma. A renal biopsy specimen revealed a massive cluster of foam cells containing apolipoprotein B and E in the mesangial region of the kidney. A restricted diet intake combined with lipid-lowering drugs such as cholestyramine, clinofibrate, and bezafibrate, in addition to methylprednisolone was not very effective in lowering serum triglyceride and cholesterol levels within physiological ranges. Therefore, plasmapheresis, using a dextran sulfate-cellulose column, was performed. Repeated plasmapheresis resulted in a marked decrease in both serum total cholesterol and triglyceride. A second renal biopsy specimen performed 2 years later revealed a marked reduction in foam cells with concurrent improvement in her nephrotic syndrome and glucose intolerance. These results suggest that familial type III hyperlipoproteinemia may be responsible for glomerular lipidosis resulting in nephrotic syndrome. They also indicate that plasmapheresis using a dextran sulfate-cellulose column is very effective in the removal of abnormal lipoproteins such as beta-very low density lipoprotein and intermediate density lipoprotein in a case of familial type III hyperlipoproteinemia.
Suzaki
K
K
Department of Metabolic Medicine, Kumamoto University Medical School, Japan.
Kobori
S
S
Ueno
S
S
Uehara
M
M
Kayashima
T
T
Takeda
H
H
Fukuda
S
S
Takahashi
K
K
Nakamura
N
N
Uzawa
H
H
D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000628:therapy; D005260:Female; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000150:complications / Q000235:genetics / Q000628:therapy*; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology; D008064:Lipidoses / Q000150:complications* / Q000628:therapy; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications* / Q000628:therapy; D010375:Pedigree; D010956:Plasmapheresis