In vitro susceptibility of mutans streptococci to antimicrobial substances as determined by a membrane transfer assay.
The in vitro susceptibilities of seven representative strains of mutans streptococci to three topically applied chemotherapeutic agents were determined by a modified membrane transfer assay. The MBCs of chlorhexidine and I2-KI ranged from 0.5 to 1.0%, while SnF2 was sublethal at the highest concentration tested (8%) in all but one strain (AHT; mode MBC, 8.0%). The proposed in vitro assay may be useful for preclinical screening of potential antimicrobial agents prior to use in the oral cavity.
Childers
N K
NK
School of Dentistry, University of Alabama, Birmingham 35294.
Caufield
P W
PW
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008567:Membranes, Artificial; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D013295:Streptococcus mutans / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial