Effects of the CCK receptor antagonist MK-329 on food intake in pigs.
The cholecystokinin (CCK) receptor antagonist MK-329 (previously L364,718) was administered intravenously (IV) (17.5-140 micrograms/kg) to pigs trained to make operant responses for food reinforcements after 4 hr of food deprivation. MK-329 produced a dose-related increase in food intake during the 2-hr test period, with maximum increases occurring at a dose of 70 micrograms/kg. CCK (1 micrograms/kg IV) produced a short-term reduction in feeding and this effect was completely abolished by pretreating the animals with MK-329 (70 micrograms/kg). The present results lend support to the hypothesis that endogenous CCK is involved in satiety.
Ebenezer
I S
IS
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
de la Riva
C
C
Baldwin
B A
BA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D020109:Devazepide; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012527:Satiation / Q000187:drug effects*; D013552:Swine
D001570:Benzodiazepinones; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D020109:Devazepide