Evidence that several high-frequency human blood group antigens reside on phosphatidylinositol-linked erythrocyte membrane proteins.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired disorder associated with absence of expression of phosphatidylinositol (PI)-linked membrane proteins from circulating hematopoietic cells of multiple lineages. Recent work demonstrated that decay accelerating factor, one such PI-linked protein, bears the Cromer-related blood group antigens. This study demonstrated that other high incidence antigens, including Cartwright (Yta/Ytb), Holley-Gregory (Hy/Gya), John Milton Hagen (JMH), and Dombrock (Doa/Dob), are absent from the complement-sensitive (PNH III) erythrocytes of patients with PNH. The relatively normal, complement-insensitive erythrocytes from the same patients express these antigens normally. Therefore, these antigens most likely reside on PI-linked proteins absent from PNH III, but not PNH I, erythrocytes.
Telen
M J
MJ
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Rosse
W F
WF
Parker
C J
CJ
Moulds
M K
MK
Moulds
J J
JJ
D000906:Antibodies; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D004910:Erythrocyte Membrane / Q000276:immunology*; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood*; D006801:Humans; D008563:Membrane Lipids / Q000097:blood*; D008565:Membrane Proteins / Q000097:blood* / Q000276:immunology; D010716:Phosphatidylinositols / Q000097:blood*; D012016:Reference Values
D000906:Antibodies; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D008563:Membrane Lipids; D008565:Membrane Proteins; D010716:Phosphatidylinositols