Strain-dependent differences in hippocampal glucocorticoid binding capacity and active avoidance in the mouse.
Maximal individual [3H]corticosterone binding capacity in the hippocampus was lower in C57BL/6 mice than in BALB/c mice, and positively correlated with active avoidance learning in the two strains. Moreover, a parallel difference in the activity of hypothalamo-pituitary adrenocortical axis (HPAA) was found, consisting in a level of plasma corticosterone in C57BL/6 higher than in BALB/c mice. These results confirm the genetically determined differences in behavior of C57BL/6 and BALB/c mice, and demonstrate their association with differences in hippocampal corticosterone binding capacity, pointing to a functional relationship between the behavioral and neuroendocrine parameters.
Patacchioli
F R
FR
Instituto di Farmacologia 2a, Medical Faculty, University of Rome, La Sapienza, Italy.
Puglisi-Allegra
S
S
Maccari
S
S
Casolini
P
P
Angelucci
L
L
Cabib
S
S
Oliverio
A
A
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003345:Corticosterone / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D011987:Receptors, Steroid; D013045:Species Specificity
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D003345:Corticosterone