[Ability of the lymphocytes in the peripheral blood of oncologic patients to repair DNA].
A study was made of the level of reparative capacity of peripheral blood lymphocytes of cancer patients in response to DNA damaging R-radiation testing at a dose of 250 Gy before the next course of cancer chemotherapy. A low capacity of peripheral blood lymphocytes for reparation of DNA or its complete suppression is characteristic for most cancer patients irrespective of a nosological entity and the number of cancer chemotherapy courses in their history. The frequency of cancer patients with the initially suppressed capacity of peripheral blood lymphocytes for DNA reparation has an increasing tendency depending on the spreading of a process. These data can serve as an additional criterion of prognosis of complication during antitumor therapy.
Nikiforova
N A
NA
Moskalenko
I P
IP
Gaĭseniuk
L A
LA
Pozhidaeva
O N
ON
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged
D000970:Antineoplastic Agents
Sposobnost' limfotsitov perifericheskoĭ krovi onkologicheskikh bol'nykh k reparatsii DNK.