Multiple-dose propranolol administration does not influence the single dose pharmacokinetics of quinapril and its active metabolite (quinaprilat).
To evaluate the influence of multiple dose propranolol administration on the single dose pharmacokinetics of quinapril and its active metabolite, quinaprilat, a drug-drug interaction study was performed in ten healthy volunteers. Each subject received a single 20 mg quinapril oral dose on Days 1 and 16 of the study. Oral propranolol doses of 40 mg BID were initiated on Day 3, titrated gradually to 80 mg TID by Day 10, and continued at 80 mg TID through Day 17. Comparable mean quinapril pharmacokinetic parameter values as well as comparable mean quinaprilat pharmacokinetic parameter values determined following quinapril administered alone and following quinapril administered with propranolol, indicate that propranolol does not alter the single dose pharmacokinetics of quinapril or quinaprilat.
Horvath
A M
AM
Warner-Lambert/Parker Davis Pharmaceutical Research Division, Ann Arbor, Michigan 48105.
Pilon
D
D
Caillé
G
G
Colburn
W A
WA
Ferry
J J
JJ
Frank
G J
GJ
Lacasse
Y
Y
Olson
S C
SC
D000328:Adult; D004347:Drug Interactions; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C054501:quinaprilat; D011433:Propranolol; D000077583:Quinapril