title: The use of a vasodilator, felodipine, as an adjuvant to long-term oxygen treatment in COLD patients.
abstract: Eight patients with chronic obstructive lung disease (COLD) and pulmonary hypertension were given an infusion of a calcium antagonist, felodipine, during ongoing, long-term oxygen treatment (LTOT). The effects on central haemodynamics and ventilation-perfusion matching were studied. At rest pulmonary and systemic vascular resistances (PVR and SVR) were reduced by 18% (NS) and 26% (p less than 0.05), respectively. Cardiac output increased by 23%. There was a tendency to increased perfusion of low alveolar ventilation-perfusion ratio (VA/Q) areas (VA/Q less than 0.1) and to increased shunt compared to pretreatment values. Arterial oxygen tension (PaO2) fell by 0.7 kPa (p less than 0.001) but total oxygen transport increased by 23% (p less than 0.001). After treatment with oral felodipine (7.5-15 mg.day-1) for a mean time of 14 wks, PVR and SVR were reduced by 16% (p less than 0.05) and 7% (NS), respectively, as compared to pretreatment values at rest. Cardiac output rose by 13%. The VA/Q ratios and the PaO2 returned towards pretreatment values. The total oxygen transport increased by 11% (p less than 0.05) at rest and increased by 19% (p less than 0.05) during exercise as compared to the pretreatment value. The positive effect on central haemodynamics indicates that felodipine may be a valuable adjunct to ongoing LTOT.
authors.affiliation: Dept of Pulmonary Medicine, Huddinge University Hospital, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Bratel
authors.forename: G
authors.initials: G
authors.lastname: Hedenstierna
authors.forename: O
authors.initials: O
authors.lastname: Nyquist
authors.forename: E
authors.initials: E
authors.lastname: Ripe
mesh_terms: D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D015736:Felodipine / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D013997:Time Factors
chemical_list: D015736:Felodipine