[Mucosa protection--an assessable value? An experimental study in rats].
Reduced mucosaprotection is a main factor for development of peptic ulcer disease. The quantity is difficult to estimate. We did it by measuring the acid output as the aggressive factor and we sized the resulting mucosalesions. In the gastric corpus we could not find any change in mucosaprotectionindex after cimetidine, pirenzepine and vagotomy. But in the duodenum protection was increased after pirenzepine and vagotomy.
Albrecht
R
R
Klinik und Poliklinik für Chirurgie, Medizinischen Akademie Erfurt, DDR.
Nowak
W
W
D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage*; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D010890:Pirenzepine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*; D015167:Vagotomy, Truncal
D010890:Pirenzepine; D002927:Cimetidine
Mukosaprotektion--eine schätzbare Grösse? Eine experimentelle Studie an Ratten.