A rapid evolution mechanism may contribute to changes in sex ratio, multiple birth incidence, frequency of auto-immune disease and frequency of birth defects in Clomid conceptions.
Under conditions favourable to the horizontal transmission of genetic material, a clomiphene isomer is hypothesized to encourage an alternate ovulatory route, with consequence for the sex ratio, multiple birth incidence, incidence of auto-immune disease, and frequency of malformations.
Fischer
K
K
Graduate School of Education, University of Pennsylvania, Philadelphia 19104.
D000014:Abnormalities, Drug-Induced / Q000235:genetics; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000235:genetics; D005075:Biological Evolution; D002996:Clomiphene / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008954:Models, Biological; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics; D011272:Pregnancy, Multiple / Q000187:drug effects; D012744:Sex Ratio
D002996:Clomiphene