Does ephedrine influence newborn neurobehavioural responses and spectral EEG when used to prevent maternal hypotension during caesarean section?
The recovery of 16 infants born by elective caesarean section with spinal anaesthesia, in which either ephedrine or fluid load was used to prevent maternal hypotension, were studied using Scanlon's neurobehavioural tests and a computerized EEG. Neurobehavioural testing showed no differences between the ephedrine and the non-ephedrine groups of infants at ages of 3 h, 1 day, 2 days and 4-5 days, whereas the spectral EEG showed significant differences between the two groups during the first 2 h after delivery, which had disappeared 24 h later. It is suggested that small doses of ephedrine given to the mother i.v. to prevent hypotension during spinal anaesthesia have short-lived effects on the neonate's central nervous system, which will be detected in the spectral EEG, but not in neurobehavioural tests.
Kangas-Saarela
T
T
Department of Anaesthesiology, University of Oulu, Finland.
Hollmén
A I
AI
Tolonen
U
U
Eskelinen
P
P
Alahuhta
S
S
Jouppila
R
R
Kivelä
A
A
Huttunen
P
P
D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002045:Bupivacaine; D002585:Cesarean Section; D002652:Child Behavior / Q000187:drug effects; D003700:Delta Rhythm / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D004809:Ephedrine / Q000627:therapeutic use*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007231:Infant, Newborn; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D011247:Pregnancy; D012018:Reflex / Q000187:drug effects*
D004809:Ephedrine; D002045:Bupivacaine