Kinetic fate of potassium embelate, a non-narcotic centrally acting analgesic after oral and intravenous administration.
The pharmacokinetics of oral and intravenous potassium embelate (20 mg/kg) was studied in rats. The results revealed that this compound follows a biexponential kinetic pattern. Absorption was complete (bioavailability 97%) and fast. The disposition half-life is 9.5 h on intravenous and 11 h on oral administration. High concentrations of the drug were found in brain between 0.25 and 2 h, which is in agreement with its pharmacological action. The kidney plays a major role in the excretion of the drug.
Zutshi
U
U
Regional Research Laboratory, Jammu Tawi, India.
Sharma
S C
SC
Kaul
J L
JL
Atal
C K
CK
D000284:Administration, Oral; D000818:Animals; D016227:Benzoquinones; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D011809:Quinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D016227:Benzoquinones; D011809:Quinones; C010945:embelin