title: Effects of multipolar electrode radiofrequency energy delivery on ventricular endocardium.
abstract: This study examined the effects of radiofrequency energy applied in a bipolar fashion with single as compared with multiple sequential applications at the canine endocardium. In this closed-chest model, radiofrequency energy (750 kHz) was delivered between two adjacent poles of an electrode catheter. Single applications were performed at distinct sites in the left (n = 30) and right ventricles (n = 29) of 13 normal dogs. A multiple sequential technique, which enlarges the ablated endocardial surface, was applied in the left (n = 13) and right ventricles (n = 4) of seven normal dogs and six dogs with remote myocardial infarction. Single applications (199 +/- 200 joules) resulted in lesions with a volume of 0.12 +/- 0.06 cm3 (range 0.03 to 0.31 cm3) and an endocardial surface area of 0.29 +/- 0.15 cm2 (range 0.06 to 0.63 cm2). Changes at the catheter/tissue interface led to a rise in impedance, restricting further enlargement of the necrosis. Sequential delivery of radiofrequency energy between poles 1 and 2, 2 and 3, and 3 and 4 of a quadripolar electrode catheter repeated 9 to 11 times in slightly different positions allowed a cumulative energy of 6571 +/- 3857 joules to be applied to the endocardium, resulting in a lesion volume of 0.84 +/- 0.38 cm3, with an endocardial lesion surface area of 3.7 +/- 1.2 cm2 (range 2.9 to 5.1 cm2). Histologically, all radiofrequency lesions were restricted to the endocardium/subendocardium with a small border zone of injury. Aggressive stimulation techniques did not induce ventricular tachycardia in any of the dogs before and 19 +/- 11.4 days after multiple sequential ablations.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of California, San Francisco.
authors.forename: M
authors.initials: M
authors.lastname: Oeff
authors.forename: J J
authors.initials: JJ
authors.lastname: Langberg
authors.forename: J O
authors.initials: JO
authors.lastname: Franklin
authors.forename: M C
authors.initials: MC
authors.lastname: Chin
authors.forename: H
authors.initials: H
authors.lastname: Sharkey
authors.forename: W
authors.initials: W
authors.lastname: Finkbeiner
authors.forename: J M
authors.initials: JM
authors.lastname: Herre
authors.forename: M M
authors.initials: MM
authors.lastname: Scheinman
mesh_terms: D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004564:Electrocoagulation / Q000379:methods*; D004699:Endocardium / Q000528:radiation effects*; D006352:Heart Ventricles; D009203:Myocardial Infarction / Q000601:surgery; D009336:Necrosis; D011846:Radio Waves; D013610:Tachycardia / Q000601:surgery*