Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells.
Neuronally differentiated PC12 cells secrete decreasing amounts of [3H]norepinephrine when repetitively stimulated by depolarizing concentrations of potassium ion. The decreasing response shows attributes that have been classically ascribed to response habituation, a behavior commonly observed in nervous systems but found here in a homogeneous cell type. Alteration of the habituation pattern was caused by activators of the protein kinase C pathway and of voltage-gated calcium channels.
McFadden
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PN
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Koshland
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DE
D000310:Adrenal Gland Neoplasms; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials; D009638:Norepinephrine / Q000378:metabolism*; D010673:Pheochromocytoma; D051381:Rats; D015290:Second Messenger Systems; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000502:physiology*
D009638:Norepinephrine