title: Complement activation in psoriasis.
abstract: Plasma from 16 patients with psoriasis and 12 healthy control subjects were measured for iC3b, C4d, and Bb fragments generated by complement activation. Plasma concentrations for iC3b, C4d, and Bb fragments were found to be significantly increased in the patients with psoriasis. The highest concentrations of these complement activation fragments were seen in patients with erythrodermic pustular psoriasis, psoriatic arthritis, and Reiter's syndrome. The serum concentrations of complement components and regulatory proteins were normal or elevated in almost all samples.
authors.affiliation: Department of Medicine (Dermatology), University of Tennessee College of Medicine, Memphis.
authors.forename: E W
authors.initials: EW
authors.lastname: Rosenberg
authors.forename: P W
authors.initials: PW
authors.lastname: Noah
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
authors.forename: R M
authors.initials: RM
authors.lastname: Jones
authors.forename: W P
authors.initials: WP
authors.lastname: Kolb
mesh_terms: D003167:Complement Activation / Q000502:physiology*; D003165:Complement System Proteins / Q000032:analysis*; D006801:Humans; D011565:Psoriasis / Q000097:blood / Q000276:immunology*
chemical_list: D003165:Complement System Proteins