[New methods of pharmacokinetic evaluation of alcohol and its metabolites in female and male probands].
The Pharmacokinetics of ethanol and its metabolites were examined in 10 young healthy women and men after 1-hr intravenous ethanol application of 7.8 mmol/kg body weight. Therefore, a new pharmacokinetic model takes into account Michaelis-Menten-elimination kinetics of ethanol as well as kinetics of acetaldehyde and acetate, which are defined by first order processes. The metabolite-model adequately describes the ethanol and acetate concentration courses. In fact, the observed ethanol concentrations are so close to the model-predicted values, that the metabolite-model allows an evaluation of half-life-times of acetaldehyde and acetate. The analyses of ethanol infusion studies showed, that there are no sex differences in parameters of ethanol elimination: Maximal elimination velocity Vmax was 3.41 +/- 0.61 mmol/l.h in females and 3.98 +/- 0.69 mmol/l.h in males. Michaelis-Menten-constant kM was 1.49 +/- 0.44 mmol/l and 1.69 +/- 0.88 mmol/l, respectively. In the female group, the volume of distribution of ethanol V1 was with 38.4 +/- 5.01 significant smaller than in males with 50.5 +/- 3.51. In conclusion, the new metabolite-model can be used as a basis for the investigation of the entire alcohol metabolism.
Kohlenberg-Müller
K
K
Institut für Ernährungswissenschaft der Justus-Liebig-Universität Giessen.
Bitsch
I
I
D000079:Acetaldehyde / Q000493:pharmacokinetics; D000085:Acetates / Q000493:pharmacokinetics; D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood*; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
D000085:Acetates; D000431:Ethanol; D000079:Acetaldehyde
Neue Methoden zur pharmakokinetischen Beschreibung des Alkohols und seiner Metaboliten bei weiblichen und männlichen Versuchspersonen.