title: In vivo effect of the organophosphorus insecticide trichlorphon on the immune response of carp (Cyprinus carpio). I. Effect of contamination on antibody production in relation to residue level in organs.
abstract: The organophosphorus insecticide trichlorphon was tested at medium (10 and 20 ppm) and high concentrations (20,000 ppm) on antibody production against Yersinia ruckeri vaccine. No statistically significant effect was observed on humoral response or on hematocrit. Contamination of organs was analyzed by acetylcholinesterase activity. At 20,000 ppm only liver and brain were highly contaminated; spleen and lymphocytes were not significantly contaminated. At 20 ppm no residue was found in organs.
authors.affiliation: Laboratoire d'Ecotoxicologie, INRA, Ecole Nationale Vétérinaire de Lyon, Marcy L'Etoile, France.
authors.forename: M
authors.initials: M
authors.lastname: Cossarini-Dunier
authors.forename: A
authors.initials: A
authors.lastname: Demael
authors.forename: A K
authors.initials: AK
authors.lastname: Siwicki
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001428:Bacterial Vaccines / Q000276:immunology; D001921:Brain / Q000187:drug effects; D002347:Carps / Q000276:immunology* / Q000378:metabolism; D003530:Cyprinidae / Q000276:immunology*; D008099:Liver / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D010573:Pesticide Residues / Q000378:metabolism*; D013154:Spleen / Q000187:drug effects; D014018:Tissue Distribution; D014236:Trichlorfon / Q000493:pharmacokinetics / Q000633:toxicity*; D015007:Yersinia / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D010573:Pesticide Residues; D014236:Trichlorfon; D000110:Acetylcholinesterase