Suppressing effects of vanillin, cinnamaldehyde, and anisaldehyde on chromosome aberrations induced by X-rays in mice.
X-ray-induced chromosome aberrations were suppressed when vanillin, cinnamaldehyde, or p-anisaldehyde was given orally to mice after X-ray irradiation. Chromosome aberrations were monitored by the occurrence of polychromatic erythrocytes with micronuclei in bone marrow cells. The frequency of micronuclei was depressed about 55-60% without toxicity of the test compounds to the bone marrow.
Sasaki
Y F
YF
Institute of Environmental Toxicology, Tokyo, Japan.
Ohta
T
T
Imanishi
H
H
Watanabe
M
M
Matsumoto
K
K
Kato
T
T
Shirasu
Y
Y
D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D001547:Benzaldehydes / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011837:Radiation-Protective Agents
D000447:Aldehydes; D001547:Benzaldehydes; D011837:Radiation-Protective Agents; D000171:Acrolein; C024896:4-anisaldehyde; C100058:vanillin; C012843:cinnamaldehyde