title: Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.
abstract: Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.
authors.affiliation: Department of Medicine, University of Washington, Seattle 98195.
authors.forename: T
authors.initials: T
authors.lastname: Enver
authors.forename: N
authors.initials: N
authors.lastname: Raich
authors.forename: A J
authors.initials: AJ
authors.lastname: Ebens
authors.forename: T
authors.initials: T
authors.lastname: Papayannopoulou
authors.forename: F
authors.initials: F
authors.lastname: Costantini
authors.forename: G
authors.initials: G
authors.lastname: Stamatoyannopoulos
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D004274:DNA, Recombinant; D004920:Erythropoiesis; D005786:Gene Expression Regulation; D005865:Gestational Age; D005914:Globins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic / Q000502:physiology; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D004274:DNA, Recombinant; D005914:Globins