Autoimmune hemolytic anemia caused by a cold agglutinin with a new specificity (anti-Ju).
A cold autoantibody detected in the serum of a patient with chronic idiopathic cold agglutinin disease and hemolytic anemia is described. The antibody reacted with adult as well as with cord red cells, and its reactivity was strongly diminished by treatment of the cells with neuraminidase and to a lesser degree by treatment with protease. Thus, the specificity of the antibody is distinct from those of all cold antibodies yet described.
Göttsche
B
B
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, FRG.
Salama
A
A
Mueller-Eckhardt
C
C
D000373:Agglutinins / Q000276:immunology*; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D000918:Antibody Specificity; D003450:Cryoglobulins; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
D000373:Agglutinins; D003450:Cryoglobulins; C029443:cold agglutinins