Oligohydramnios in each sac of a triplet gestation caused by Motrin--fulfilling Kock's postulates.
A triplet gestation was treated with Motrin for oral tocolysis. A significant reduction of amniotic fluid was observed, but this was corrected by stopping the drug. A cause-and-effect relationship was established by restarting the Motrin and observing the same development of oligohydramnios, which again returned to normal with discontinuation of the drug.
Wiggins
D A
DA
Department of Obstetrics and Gynecology, Good Samaritan Medical Center, Phoenix, Arizona.
Elliott
J P
JP
D000328:Adult; D000653:Amniotic Fluid / Q000187:drug effects*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D007213:Indomethacin / Q000009:adverse effects; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D012079:Renal Circulation / Q000187:drug effects; D015149:Tocolytic Agents / Q000009:adverse effects*; D014310:Triplets
D015149:Tocolytic Agents; D007052:Ibuprofen; D007213:Indomethacin