[The effect of nitrofuran and asymmetrically substituted urea on Trichomonas vaginalis and Tritrichomonas foetus in vitro and in vivo].
Antitrichomonal activity of selected nitrofuran derivatives and asymmetrically substituted ureas was investigated in vitro and in vivo and compared with the activity of the effective therapeutic agent tinidazole. In experimental infection with Trichomonas vaginalis and Tritrichomonas foetus in mice, some substituted urea derivatives exhibited an antiparasitic effect slightly lower than that of tinidazole. The substance N1-(3-nitrophenyl)-N3-(2-pyrimidinyl)urea proved to be the most effective of the substances tested. On the basis of preliminary toxicity tests the chemotherapeutic value of this substance appears to be promising.
Macicková
T
T
Ustav experimentálnej farmakológie CFV SAV, Bratislava.
Kettner
M
M
Benes
L
L
D000818:Animals; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009581:Nitrofurans / Q000494:pharmacology* / Q000633:toxicity; D011528:Protozoan Infections / Q000188:drug therapy; D014246:Trichomonas vaginalis / Q000187:drug effects*; D014318:Tritrichomonas / Q000187:drug effects*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D009581:Nitrofurans; D014508:Urea
Ucinok nitrofuránov a nesymetricky substituovaných mocovín na Trichomonas vaginalis a Tritrichomonas foetus in vitro a in vivo.