Effect of verapamil on different spermatozoal functions in guinea pigs--a preliminary study.
Verapamil, a calcium channel blocker, was administered orally using three different doses to guinea pigs. Both short-term (4 weeks) and long-term (12 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and cellular energy content (ATP). Zona pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Histopathological findings exhibited partial arrest of spermatogenesis. Partial to complete recovery was observed after 4 and 6 weeks of withdrawal of the drug treatment.
Juneja
R
R
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
I
I
Wali
A
A
Sanyal
S N
SN
Chakravarti
R N
RN
Majumdar
S
S
D000255:Adenosine Triphosphate / Q000032:analysis; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects; D006168:Guinea Pigs; D008297:Male; D009929:Organ Size; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013084:Sperm-Ovum Interactions / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D000255:Adenosine Triphosphate; D014700:Verapamil