N-acetylation phenotyping with sulphadimidine in a Turkish population.
The distribution of acetylator phenotypes was studied in 244 unrelated Turkish subjects. Sulphadimidine and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples after an oral dose of 10 mg/kg. Subjects with 37.5% or less acetylsulphadimidine in plasma were regarded as slow acetylators and the others as rapid acetylators. The mean plasma concentration of acetylsulphadimidine was about 2.5-times lower in slow acetylators. Urinary excretion of total sulphadimidine (free + acetylated) was also significantly lower in slow acetylators compared to rapid acetylators. The frequency of slow acetylators was 60.7% in the population (95% confidence interval 54.3% to 66.8%). Sulphadimidine acetylation showed no variation due to sex, age, body weight or pre-existing disease.
Bozkurt
A
A
Hacettepe University, School of Medicine, Department of Pharmacology, Ankara, Turkey.
Basci
N E
NE
Kalan
S
S
Tuncer
M
M
Kayaalp
S O
SO
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013418:Sulfamethazine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D013997:Time Factors; D014421:Turkey
C032633:N-acetylsulfamethazine; D013418:Sulfamethazine