title: Value of urinary neopterin in the differential diagnosis of bacterial and viral infections.
abstract: Neopterin is released by stimulated macrophages. In this study we analyzed the diagnostic potential of urinary neopterin concentrations in patients with bacterial and viral infection. All but one of 17 patients with viral infection had increased urinary neopterin concentrations. Patients with bacterial urinary tract infection also showed increased neopterin concentrations, whereas patients with bacterial pneumonia had significantly lower neopterin levels. In addition, patients with acute bacterial pneumonia had lower neopterin levels than patients with protracted infection. A significant inverse correlation between urinary neopterin and hemoglobin concentrations was found. Neopterin concentrations could serve as a helpful additional marker of infectious diseases. Combined with other clinical and laboratory parameters it is a useful parameter for distinguishing between viral and bacterial origins of infection, as was shown by multivariate stepwise linear discriminant analysis.
authors.affiliation: Universitätsklinik für Innere Medizin, Universität Innsbruck.
authors.forename: H
authors.initials: H
authors.lastname: Denz
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: A
authors.initials: A
authors.lastname: Hausen
authors.forename: H
authors.initials: H
authors.lastname: Huber
authors.forename: D
authors.initials: D
authors.lastname: Nachbaur
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: J
authors.initials: J
authors.lastname: Thaler
authors.forename: E R
authors.initials: ER
authors.lastname: Werner
authors.forename: H
authors.initials: H
authors.lastname: Wachter
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000175:diagnosis* / Q000652:urine; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis; D006506:Hepatitis A / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D012141:Respiratory Tract Infections / Q000175:diagnosis; D014552:Urinary Tract Infections / Q000175:diagnosis; D014777:Virus Diseases / Q000175:diagnosis* / Q000652:urine
chemical_list: D001708:Biopterins; D019798:Neopterin