title: Ineffectiveness and comparative pathogenicity of attenuated rabies virus vaccines for the striped skunk (Mephitis mephitis).
abstract: Three attenuated rabies virus vaccines (SAD-B19, ERA/BHK-21, AZA 2) were compared for efficacy and safety in the striped skunk (Mephitis mephitis) by the oral and intranasal routes. The SAD-B19 and ERA/BHK-21 vaccines were given orally; all three vaccines were given intranasally. Oral administration of SAD-B19 and ERA/BHK-21 vaccines induced neither seroconversion nor significant protection against rabies challenge. One skunk which consumed a SAD-B19 vaccine-laden bait succumbed to vaccine-induced rabies. Intranasal instillation of the three vaccines resulted in the deaths of two of six (AZA 2), three of six (ERA/BHK-21) and six of six (SAD-B19) skunks.
authors.affiliation: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
authors.forename: C E
authors.initials: CE
authors.lastname: Rupprecht
authors.forename: K M
authors.initials: KM
authors.lastname: Charlton
authors.forename: M
authors.initials: M
authors.lastname: Artois
authors.forename: G A
authors.initials: GA
authors.lastname: Casey
authors.forename: W A
authors.initials: WA
authors.lastname: Webster
authors.forename: J B
authors.initials: JB
authors.lastname: Campbell
authors.forename: K F
authors.initials: KF
authors.lastname: Lawson
authors.forename: L G
authors.initials: LG
authors.lastname: Schneider
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002335:Carnivora; D005260:Female; D008297:Male; D012889:Mephitidae; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D011820:Rabies virus / Q000276:immunology; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated