[Increase of the functional activity of natural killers under the effects of the pharmacological correction of the sympathoadrenal system state in patients with lung cancer].
The influence of drugs improving sympathoadrenal system status on natural killer (NK) functional activity was studied in lung cancer patients. The activity of adenosine-metabolizing enzymes (adenosine deaminase and 5'-nucleotidase) in NK cells was found significantly altered, suggesting the involvement of this phenomenon in decreasing NK activity under tumor growth. Pharmacological correction of sympathoadrenal system status was followed by an increase in NK functional activity in lung cancer patients.
Umanskiĭ
V Iu
VIu
Balitskaia
E K
EK
Shmal'ko
Iu P
IuP
Kas'ianenko
I V
IV
D015720:5'-Nucleotidase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology / Q000276:immunology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology*; D008875:Middle Aged; D010096:Oxprenolol / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014814:Vitamin U / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D014815:Vitamins; D014814:Vitamin U; D010096:Oxprenolol; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase
Povyshenie funktsional'noĭ aktivnosti estestvennykh killerov pod vliianiem farmakologicheskoĭ korrektsii sostoianiia simpatoadrenalovoĭ sistemy u bol'nykh rakom legkogo.