Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster.
We conducted a 14 day experiment in which we administered camostate (a trypsin inhibitor) and cholecystokinin alone or in combination with lorglumide, a cholecystokinin receptor antagonist, to both rats and hamsters. Plasma cholecystokinin levels were 21.7 +/- 3.2 pM and 19.6 +/- 2.5 pM with camostate, 16.3 +/- 2.4 pM and 14.8 +/- 2.2 pM with exogenous cholecystokinin, and 3.7 +/- 0.4 pM and 4.2 +/- 1.0 pM in control experiments in rats and hamsters, respectively. Both cholecystokinin and camostate were found to promote pancreatic growth in rats (18 +/- 4 and 111 +/- 7%, respectively) and hamsters (76 +/- 18 and 61 +/- 12%, respectively). Although lorglumide caused a decrease of this effect of camostate in both rats (78 +/- 5%) and hamsters (25 +/- 10%), it only became significant in rats. We therefore conclude that there are important interspecies differences in the role cholecystokinin plays in mediating the trophic effects of trypsin inhibitors on the pancreas.
Douglas
B R
BR
Dept. of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Woutersen
R A
RA
Jansen
J B
JB
Rovati
L C
LC
Lamers
C B
CB
D000818:Animals; D002766:Cholecystokinin / Q000097:blood / Q000494:pharmacology; D006224:Cricetinae; D004247:DNA / Q000032:analysis; D004952:Esters; D016670:Gabexate / Q000031:analogs & derivatives*; D005780:Gelatin / Q000494:pharmacology; D005973:Glutamine / Q000031:analogs & derivatives*; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000254:growth & development; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D004952:Esters; D006146:Guanidines; D011506:Proteins; D014361:Trypsin Inhibitors; C034532:camostat; D005973:Glutamine; D016670:Gabexate; D005780:Gelatin; D004247:DNA; D002766:Cholecystokinin; D011377:Proglumide; C048181:lorglumide