Effects of selenium and vitamin E on muscular strength and blood parameters in Steinert disease.
Six patients with Steinert disease were treated with selenium and vitamin E, for a 24 month period, including a first phase of 12 months, 6 months wash-out interval and a second treatment phase of 6 months. Mean segmental strength values showed significant improvement during the first 12 months of therapy, while marked reductions of serum enzymes CPK, SGOT, SGPT and gamma-GT were observed in some patients. The results support the hypothesis that selenium may play a role in the development of muscle damage in Steinert disease.
Rossi
B
B
Istituto di Clinica Neurologica dell'Università di Pisa.
Siciliano
G
G
Risaliti
R
R
Muratorio
A
A
D000328:Adult; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009132:Muscles / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D009135:Muscular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D012643:Selenium / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D012643:Selenium