Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease.
To assess the significance of serum basement membrane- and type III procollagen-related antigens in reflecting the degree of liver fibrosis, we measured radioimmunologically the concentrations of 7S collagen, laminin fragment P1, and the aminoterminal propeptide of type III procollagen (P-III-P) in serum from 48 patients with chronic viral liver disease: chronic persistent hepatitis (9), chronic active hepatitis (13), chronic active hepatitis with lobular disorganization (17), and liver cirrhosis (9). Concentrations of 7S collagen, laminin P1, and P-III-P in serum were increased in respectively 92%, 69%, and 77% of the patients with both chronic active hepatitis with lobular disorganization and liver cirrhosis. Concentrations of 7S collagen and laminin P1 in serum correlated well (r = 0.65, P less than 0.001, and r = 0.55, P less than 0.001, respectively) with the histological grade of liver fibrosis, whereas P-III-P correlated only weakly (r = 0.33, P less than 0.05). Evidently, measurement of serum 7S collagen is a reliable noninvasive test for detection of fibrosis in chronic viral liver disease.
Misaki
M
M
Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Shima
T
T
Yano
Y
Y
Sumita
Y
Y
Kano
U
U
Murata
T
T
Watanabe
S
S
Suzuki
S
S
D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000378:metabolism*; D002908:Chronic Disease; D003094:Collagen / Q000097:blood; D005260:Female; D006505:Hepatitis / Q000097:blood*; D006521:Hepatitis, Chronic / Q000097:blood; D006801:Humans; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood*
D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C055716:laminin P1; D003094:Collagen