Site of regulation of nanaomycin biosynthesis by inorganic phosphate.
The site of regulation of nanaomycin biosynthesis by inorganic phosphate was studied with washed cells previously grown in a chemically defined medium containing a high- or low-phosphate concentration. The former mycelia produced only about one-tenth the amount of nanaomycin A from acetate as did the latter mycelia. On the other hand, the bioconversions of nanaomycin D to A and nanaomycin A to E were only slightly affected. It is suggested that the site of regulation of nanaomycin biosynthesis by inorganic phosphate lies within steps between acetate and nanaomycin D.
Masuma
R
R
Kitasato Institute, Kitasato University, Tokyo, Japan.
Zhen
D Z
DZ
Tanaka
Y
Y
Omura
S
S
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D009285:Naphthoquinones / Q000378:metabolism*; D010710:Phosphates / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism; D000095622:Benzoisochromanequinones
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009285:Naphthoquinones; D010710:Phosphates; C008638:nanaomycin A; D000095622:Benzoisochromanequinones; C023430:nanaomycin E; C013079:kalafungin