5-HT1 receptor agonists reduce the Ca+ component of sensory neuron action potentials.
Serotonin (5-HT) agonists, selective for 5-HT1, 5-HT2 or 5-HT3 receptor subtypes, were tested for their ability to mimic 5-HT in narrowing the tetraethylammonium-induced calcium-dependent plateau of action potentials recorded from frog sensory neurons. 5-Carboxamidotryptamine, 5-HT, alpha-methyl 5-HT and 5-methoxy-tryptamine possessed full agonist activity, with EC50S of 19 nM, 210 nM, 3.7 microM and 1.7 microM, respectively. 2-Methyl 5-HT was inactive. This agonist profile indicates that the calcium-dependent plateau in these sensory somata is modulated by a 5-HT1-like receptor.
Scroggs
R S
RS
Department of Pharmacology, University of Illinois College of Medicine, Chicago 60612.
Anderson
E G
EG
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D002118:Calcium / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000187:drug effects; D066298:In Vitro Techniques; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D011985:Receptors, Serotonin; D013757:Tetraethylammonium Compounds; C042390:alpha-methylserotonin; D012701:Serotonin; D008735:5-Methoxytryptamine; C047087:5-carboxamidotryptamine; D002118:Calcium