title: Demonstration of vascular permeability changes in cattle infected with bovine ephemeral fever virus.
abstract: Five cattle infected with bovine ephemeral fever virus were necropsied on the day after onset of clinical disease, when clinical signs of lameness were most severe. Gross lesions observed included a serofibrinous polyserositis involving the synovial, pericardial, thoracic and abdominal cavities. The associated histological changes consisted primarily of oedema and an influx of neutrophils into affected tissues and fluids. In a further eight infected cattle, increases in permeability of vessels associated with serosal surfaces were demonstrated by labelling with either colloidal carbon or Evans blue. Intravenous injections of carbon provided both macroscopic and histological labelling of affected vessels. Evans blue appeared to be more sensitive than carbon but did not provide a histological marker of vascular permeability and provided labelling of tissues rather than individual vessels. The main sites of increased permeability were synovial, pericardial, thoracic and abdominal serosae.
authors.affiliation: Department of Veterinary Pathology and Public Health, University of Queensland, St Lucia, Australia.
authors.forename: P L
authors.initials: PL
authors.lastname: Young
authors.forename: P B
authors.initials: PB
authors.lastname: Spradbrow
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D002244:Carbon; D002417:Cattle; D003102:Colloids; D004810:Ephemeral Fever / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D007596:Joints / Q000473:pathology; D008168:Lung / Q000473:pathology; D009852:Omentum / Q000473:pathology; D013583:Synovial Membrane / Q000473:pathology
chemical_list: D003102:Colloids; D002244:Carbon