The number of alleles in multigene families.
The probability distribution and moments of the number of alleles present in a sample of homologous chromosomes are studied. It is assumed that there are multiple copies of the gene on each chromosome. When there are only two copies per chromosome or when there are only two or three chromosomes, it is possible to use analytic methods to tackle the problem. Otherwise, a simulation method is suggested.
Griffiths
R C
RC
Department of Mathematics, Monash University, Clayton, Victoria, Australia.
Watterson
G A
GA
D000483:Alleles; D002874:Chromosome Mapping; D003198:Computer Simulation; D005785:Gene Conversion; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D005810:Multigene Family; D009154:Mutation