title: [Peculiar increase of plasma plasminogen activator inhibitor 1 levels in patients with hemophagocytic histiocytosis].
abstract: There was a markedly significant increase of plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor 1 (PAI-1) and PAI activity in 3 patients with hemophagocytic histiocytosis (HPH) as compared with DIC patients with multi-organ failure (MOF). Of particular interest was the peculiar increase of PAI-1 levels, that is, the average PAI-1 level was 2,673 ng/ml, while that in DIC patients with MOF was 66 ng/ml. We conclude that the striking increase of plasma PAI-1 levels may be a pathognomonic feature of HPH and may contribute to the pathogenesis of DIC and/or MOF associated with HPH.
authors.affiliation: Third Department of Internal Medicine, School of Medicine, Kagoshima University.
authors.forename: K
authors.initials: K
authors.lastname: Shimmyozu
authors.forename: N
authors.initials: N
authors.lastname: Kadokura
authors.forename: T
authors.initials: T
authors.lastname: Itoyama
authors.forename: M
authors.initials: M
authors.lastname: Tara
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000293:Adolescent; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood*
chemical_list: D015849:Plasminogen Inactivators