Human metabolism of arsenobetaine ingested with fish.
1. Six volunteers ingested 74As-labelled arsenobetaine with a fish meal. The retention and distribution of the tracer were studied by body radioactivity measurements. 2. The tracer became rapidly dispersed in soft tissues, with no major concentration in any localized organ or region. 3. In all subjects less than 1% of the ingested activity remained in the body after 24 days. 4. Any losses from the skin were minor in relation to those by other routes of excretion.
Brown
R M
RM
Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxon, UK.
Newton
D
D
Pickford
C J
CJ
Sherlock
J C
JC
D000328:Adult; D000818:Animals; D001151:Arsenic / Q000378:metabolism; D001152:Arsenicals / Q000378:metabolism* / Q000493:pharmacokinetics; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution
D001152:Arsenicals; D011868:Radioisotopes; D001151:Arsenic; C038992:arsenobetaine