An investigation of oligopeptides linking domains in protein tertiary structures and possible candidates for general gene fusion.
Fifty-one examples of oligopeptides linking protein domains were extracted from the Brookhaven database of three-dimensional protein structures. In general, the peptides displayed specific characteristics in composition, conformation, hydrogen bonding, flexibility and the like. The entire database was then searched for pentapeptides that would optimize these natural linker properties. The oligopeptides found are suggested as general candidates to link protein molecules or domains through gene fusion.
Argos
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European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany.
D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004798:Enzymes / Q000235:genetics; D046911:Macromolecular Substances; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009842:Oligopeptides; D011487:Protein Conformation; D011506:Proteins / Q000235:genetics
D004798:Enzymes; D046911:Macromolecular Substances; D009842:Oligopeptides; D011506:Proteins