title: Limit of T cell tolerance to self proteins by peptide presentation.
abstract: Cytotoxic T lymphocytes (CTLs) recognize foreign peptides bound to major histocompatibility complex (MHC) class I molecules. MHC molecules can also bind endogenous self peptides, to which T cells are tolerant. Normal mice contained CTLs specific for self peptides that were from proteins of ubiquitous or tissue-restricted expression. In vivo, these endogenous self peptides are not naturally presented in sufficient density by somatic cells expressing MHC class I molecules. They can, however, be presented if added exogenously. Thus, our data imply that CTLs are only tolerant of those endogenous self peptide sequences that are presented by MHC class I-positive cells in a physiological manner.
authors.affiliation: Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen, Federal Republic of Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schild
authors.forename: O
authors.initials: O
authors.lastname: Rötzschke
authors.forename: H
authors.initials: H
authors.lastname: Kalbacher
authors.forename: H G
authors.initials: HG
authors.lastname: Rammensee
mesh_terms: D000818:Animals; D015551:Autoimmunity; D002460:Cell Line; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; D010446:Peptide Fragments