Fibrin deposition and adaptive changes in glomerular procoagulant and fibrinolytic activities in rat renoprival nephropathy.
To investigate the mechanisms which may influence fibrin deposition in the remnant kidney, glomerular morphology and the haemostatic properties of isolated glomeruli were assessed in two groups of rats, 30 days after surgical removal of three-quarters of the total renal parenchyma, and compared to glomeruli in sham-operated controls. One group was given the thromboxane synthetase inhibitor OKY 046 and the other was not. Fibrin deposition occurred in about 20% of glomeruli, of which 4% exhibited segmental necrotizing lesions. Concomitantly, glomerular procoagulant activity dropped to 40% of the control level and glomerular fibrinolytic activity rose to 120-130% of this level. Inhibition of thromboxane synthesis did not affect fibrin deposition, glomerular haemostasis or the development of renal insufficiency. In an additional group of unilaterally nephrectomized rats, procoagulant activity also markedly decreased in the remaining kidney. These results indicate that in the rat remnant kidney, alterations in glomerular haemostatic properties tend to have antithrombotic effects which seem to constitute an adaptive reaction by an autacoid system to glomerular fibrin deposition.
Ruedin
P
P
Service de Néphrologie, l'Institut National de la Santé et de la Recherche Médicale, Paris, France.
Mougenot
B
B
Ruedin
D
D
Rondeau
E
E
Sraer
J D
JD
Lacave
R
R
Kanfer
A
A
D000222:Adaptation, Physiological; D000818:Animals; D001777:Blood Coagulation; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D008689:Methacrylates; D051381:Rats; D011919:Rats, Inbred Strains; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D008689:Methacrylates; D005337:Fibrin; D013930:Thromboxane-A Synthase; C034364:ozagrel