title: Fetal liver cell transplantation in scid mice.
abstract: Mice with severe combined immunodeficiency (CB 17 scid) received isogeneic and allogeneic fetal liver cell transplantation. Immunological reconstitution was followed by immunoglobulin production, mitogen-induced proliferation, spleen and thymus lymphoid recolonization. Scid mice injected with isogeneic fetal liver cells showed normal IgM, IgG production and subnormal Con-A induced proliferation. Lymphoid organs were gradually repopulated. Mice having received allogeneic stem cells presented normal IgM and IgG secretion. They still had no mitogen-induced lymphocyte stimulation, two months after fetal cell transplantation, despite satisfactory repopulation of spleen and thymus. Reconstitution of cell-mediated immunity may be somewhat slower following allogeneic than isogeneic stem cell transplantation.
authors.affiliation: Transplantation and Immunobiology Laboratory, Hôpital Edouard Herriot, Lyon, France.
authors.forename: K
authors.initials: K
authors.lastname: Sanhadji
authors.forename: M S
authors.initials: MS
authors.lastname: Negrier
authors.forename: J L
authors.initials: JL
authors.lastname: Touraine
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D016031:Liver Transplantation; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains
chemical_list: D007136:Immunoglobulins