title: Sudden death in rheumatoid arthritis from vertical subluxation of the odontoid process.
abstract: Rheumatoid arthritis is a chronic, multisystem disease that causes significant morbidity and early mortality. A common source of morbidity in severe rheumatoid arthritis is involvement of the cervical spine. Sudden death due to subluxation of the odontoid process into the medulla oblongata is a dramatic but rare complication. We report the case of a patient who died suddenly. Computerized tomography scan, autopsy, and clinical findings were correlated. Studies of cervical involvement in rheumatoid arthritis were analyzed for cases of vertical subluxation. The case reports of sudden deaths and patients treated for vertical subluxation were reviewed; they revealed a trend toward surgery in patients with neurological abnormalities. However, a comparison of clinical outcome does not demonstrate improved survival with surgical intervention. Randomized trials comparing surgical with nonsurgical therapy are needed.
authors.affiliation: Mercer University School of Medicine, Macon, GA.
authors.forename: D C
authors.initials: DC
authors.lastname: Parish
authors.forename: J A
authors.initials: JA
authors.lastname: Clark
authors.forename: S M
authors.initials: SM
authors.lastname: Liebowitz
authors.forename: W C
authors.initials: WC
authors.lastname: Hicks
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000000981:diagnostic imaging; D001368:Axis, Cervical Vertebra / Q000473:pathology*; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D006801:Humans; D008526:Medulla Oblongata / Q000000981:diagnostic imaging / Q000293:injuries*; D009809:Odontoid Process / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed