[Analysis of 123I IMP retention in the lung and application to the diagnosis of lung disease].
The movement of N-isopropyl-p[123I] iodoamphetamine (I-123 IMP) in the lungs was studied. The half time of I-123 IMP release (T 1/2) was delayed in the fibrosis and the sarcoidosis. There was a relation between the prolongation of T 1/2 and the radiographic finding. It was considered that T 1/2 was useful for the objective estimation of the change in the lungs. The adsorption of I-123 IMP to the alveolar cells was much higher than to the circulating leukocytes. It was considered that the accumulation and retention of I-123 IMP in the lungs had relation to the alveolar cells.
Ikeda
H
H
First Department of Internal Medicine, Yamagata University School of Medicine.
Komatsu
M
M
Takahashi
K
K
Yasui
S
S
Mariko
M
M
D000662:Amphetamines / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008168:Lung / Q000378:metabolism*; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine