Pharmacokinetics of N-nitrodimethylamine and N-nitromethylamine in the rat.
Oxidative metabolism of radioactively labeled N-nitrodimethylamine in rats was compared with that of N-nitromethylamine. Within 7 h, 20% of N-nitrodimethylamine was metabolized to CO2 but only 4% of N-nitromethylamine. The poor oxidative metabolism of N-nitromethylamine is also reflected in the blood levels determined after i.v. administration to catheterized rats. N-Nitrodimethylamine was cleared rapidly from rat blood, while N-nitromethylamine was rapidly distributed into body water but had a long elimination half-life. An amount equal to 5.2% of the dose of the monomethyl compound was excreted intact in urine, but only 0.004% of the dimethyl compound. The pharmacokinetic data obtained were compared with the published data on the pharmacokinetics of the structural analog N-nitrosodimethylamine.
Hassel
M
M
German Cancer Research Center, Institute of Toxicology and Chemotherapy, Heidelberg, FRG.
Frei
E
E
Streeter
A J
AJ
Wiessler
M
M
D000818:Animals; D002250:Carbon Radioisotopes; D002273:Carcinogens / Q000493:pharmacokinetics*; D004123:Dimethylamines / Q000493:pharmacokinetics*; D008297:Male; D008744:Methylamines / Q000493:pharmacokinetics*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D002273:Carcinogens; D004123:Dimethylamines; D008744:Methylamines; C061688:N-nitromethylamine; C013962:dimethylnitramine