title: Lysosomal tartrate sensitive acid phosphatase deficiency in cells which contain lysosomal "high uptake forms".
abstract: The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marker. The results presented indicate that this phenomenon is related to a low activity or the complete absence of the lysosomal tartrate sensitive acid phosphatase activity in the tissues concerned.
authors.affiliation: Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Hu
authors.forename: G
authors.initials: G
authors.lastname: Parenti
authors.forename: J
authors.initials: J
authors.lastname: Keulemans
authors.forename: A T
authors.initials: AT
authors.lastname: Hoogeveen
mesh_terms: D000135:Acid Phosphatase / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000378:metabolism*; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007118:Immunoassay; D007700:Kinetics; D008247:Lysosomes / Q000201:enzymology*; D008264:Macrophages / Q000201:enzymology; D008297:Male; D008970:Molecular Weight; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D013644:Tartrates / Q000494:pharmacology*; D013737:Testis / Q000201:enzymology
chemical_list: D013644:Tartrates; D000135:Acid Phosphatase