Characterization of a tissue kallikrein in human prolactin-secreting adenomas.
Immunoreactive tissue kallikrein was co-localized with prolactin in all the eleven prolactin-secreting adenomas of the human anterior pituitary gland examined in this study. The intracellular distribution of immunoreactivity in the prolactin-secreting cells suggests that tissue kallikrein is located within the Golgi complex of these cells. Both the intracellular hormone-processing action and the kininogenase activity of tissue kallikrein may be of functional importance in human prolactinomas.
Jones
T H
TH
University Department of Medicine, Northern General Hospital, Sheffield.
Figueroa
C D
CD
Smith
C
C
Cullen
D R
DR
Bhoola
K D
KD
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007610:Kallikreins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000032:analysis* / Q000378:metabolism; D011388:Prolactin / Q000032:analysis / Q000378:metabolism; D015175:Prolactinoma / Q000032:analysis* / Q000378:metabolism
D011388:Prolactin; D007610:Kallikreins