title: [Hodgkin's disease associated with Tolosa-Hunt syndrome].
abstract: A thirty-eight-year-old man developed gradually progressing right retro-orbital pain, diplopia on the left lateral gaze, and left ptosis. On examination paresthesia was present on the first division of right trigeminal nerve. Orbital venography revealed obstruction of right superior orbital vein on the entering portion to the cavernous sinus. A daily administration of 30 mg of prednisolone resulted in a rapid improvement of the symptoms. Diagnosis of Tolosa-Hunt syndrome was made on the basis of neurological symptoms, roentgenographic findings and responsiveness to prednisolone. One year later, weakness of right leg accompanied with left cervical and axillary lymphadenopathy was developed. A biopsy specimen of cervical lymph node was identical with the Hodgkin's disease, lymphocyte predominance type. He was treated with COPP regimen; lymphadenopathy decreased in size. We reported a rare case of Hodgkin's disease preceded by Tolosa-hunt syndrome which might be caused by the extranodal lesions.
authors.affiliation: Department of Internal Medicine, Yokosuka Kyosai Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Kanayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kimula
authors.forename: H
authors.initials: H
authors.lastname: Akabane
mesh_terms: D000328:Adult; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D009886:Ophthalmoplegia / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D011239:Prednisolone