Expression of immunoreactivity for Ca-binding protein, spot 35 in the interstitial cell of the rat pineal organ.
In the rat pineal organ numerous stellate cells exhibited intense immunoreactivity for calcium-binding spot 35 protein. Because of their peculiar shape and ultrastructure, identical to those of intrapineal S-100-immunoreactive cells, the spot 35-immunoreactive stellate cells were identified as the interstitial cells. The comparison of the morphology and population density of spot 35-, S-100-, and GFAP (glial fibrillar acidic protein)-immunoreactive cells, suggests that spot 35-immunoreactive cells represent a major subpopulation of the interstitial cells, all of which are S-100-immunoreactive and generally considered to be of glial nature, while GFAP-immunoreactive cells represent a minor subpopulation of the interstitial cells located in the proximal part close to the pineal stalk. This is the first report describing the occurrence of the calcium-binding protein in cells of glial nature.
Yamamoto
M
M
Department of Anatomy, School of Medicine, Kanazawa University, Japan.
Kondo
H
H
Yamakuni
T
T
Takahashi
Y
Y
D000818:Animals; D017317:Annexin A6; D015415:Biomarkers; D002135:Calcium-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D010870:Pineal Gland / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism
D017317:Annexin A6; D015415:Biomarkers; D002135:Calcium-Binding Proteins; C030564:S-100 calcium-binding protein alpha subunit; D009418:S100 Proteins