title: Lack of cardiovascular side effects of the new tricyclic antidepressant tianeptine. A double-blind, placebo-controlled study in young healthy volunteers.
abstract: In a double-blind, placebo-controlled, crossover study, the effects of therapeutic doses of the new tricyclic antidepressant tianeptine on cardiovascular function were closely monitored in 21 healthy volunteers during a 2-week treatment period. Blood pressure measurements, ECG recording, 24-h Holter monitoring, and echocardiography were carried out at 1-week intervals. Isotopic ventriculography was measured twice under each treatment. Tianeptine did not produce orthostatic hypotension or increase heart rate. No ECG changes could be observed and the cardiac conduction time remained unchanged. One subject presented with an increase in frequency of ventricular premature beats that could not be definitely attributed to the drug. Cardiac output assessed at rest and after a bicycle exercise stress test was not altered. The present study suggests that tianeptine is a tricyclic antidepressant endowed with less cardiac toxicity than classical tricyclic antidepressants.
authors.affiliation: Department of Nuclear Medicine, University Hospital André Vésale, Montigny-le-Tilleul, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Juvent
authors.forename: J
authors.initials: J
authors.lastname: Douchamps
authors.forename: E
authors.initials: E
authors.lastname: Delcourt
authors.forename: W
authors.initials: W
authors.lastname: Kostucki
authors.forename: C
authors.initials: C
authors.lastname: Dulcire
authors.forename: D
authors.initials: D
authors.lastname: d'Hooge
authors.forename: A
authors.initials: A
authors.lastname: Herchuelz
mesh_terms: D000328:Adult; D000790:Angiocardiography; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000097:blood; D004311:Double-Blind Method; D004452:Echocardiography; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013841:Thiazepines / Q000009:adverse effects* / Q000097:blood
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine