Deep partial skin thickness burns: a reproducible animal model to study burn wound healing.
A reproducible deep partial skin thickness burn model using guinea-pigs to study the healing process of this injury is described. Round aluminium templates heated to 75 degrees C and applied for 5 s to the moistened, clipped and depilated dorsal skin produced the desired depth of injury. This model is applicable for the study of the three main components of the burn wound healing process: epithelialization, contraction and scar formation. It is recommended that the India ink injection technique be used to confirm the depth of the burn wound.
Kaufman
T
T
Department of Plastic Surgery, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
Lusthaus
S N
SN
Sagher
U
U
Wexler
M R
MR
D000818:Animals; D001706:Biopsy; D002056:Burns / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D014945:Wound Healing / Q000502:physiology*