title: HLA-A, B, C and DR antigens in nickel contact sensitivity.
abstract: The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P less than 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.
authors.affiliation: Department of Dermatology, University of Milan, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Mozzanica
authors.forename: L
authors.initials: L
authors.lastname: Rizzolo
authors.forename: G
authors.initials: G
authors.lastname: Veneroni
authors.forename: R
authors.initials: R
authors.lastname: Diotti
authors.forename: S
authors.initials: S
authors.lastname: Hepeisen
authors.forename: A F
authors.initials: AF
authors.lastname: Finzi
mesh_terms: D000293:Adolescent; D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015808:HLA-DR6 Antigen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D012306:Risk
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D015808:HLA-DR6 Antigen; D009532:Nickel