[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
Le Luyer
B
B
Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier, Le Havre.
Mougenot
J F
JF
Mashako
L
L
Chapoy
P
P
Olives
J P
JP
Morali
A
A
Chevallier
B
B
Ginies
J L
JL
Dupont
C
C
Dagorne
M
M
D000464:Alginates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D013535:Suspensions
D000464:Alginates; D013535:Suspensions
Efficacité pharmacologique de l'alginate de sodium suspension sur le reflux gastro-oesophagien du nourrisson et de l'enfant.