Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.
Two novel antibiotics, furaquinocins A and B were isolated from the culture broth of Streptomyces sp. KO-3988. These antibiotics possess cytocidal activities against HeLa S3 cells in vitro at concentrations of 3.1 micrograms/ml for A and 1.6 micrograms/ml for B. Neither substance possessed antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.
Komiyama
K
K
Kitasato Institute, Tokyo, Japan.
Funayama
S
S
Anraku
Y
Y
Ishibashi
M
M
Takahashi
Y
Y
Omura
S
S
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D016227:Benzoquinones; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011809:Quinones / Q000032:analysis / Q000302:isolation & purification / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013171:Spores, Bacterial; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D011809:Quinones; C063723:furaquinocin A; C063724:furaquinocin B