Lipid A, the immunostimulatory principle of lipopolysaccharides?
Lipid A has been found to be an inducer of IL-1 with similar potency as LPS. Partial structures of lipid A or core oligosaccharides are less active or not active at all. We propose that lipid A is the structure responsible for induction of immunostimulatory or immunoregulatory properties of LPS.
Loppnow
H
H
Forschungsinstitut Borstel, FRG.
Dürrbaum
I
I
Brade
H
H
Dinarello
C A
CA
Kusumoto
S
S
Rietschel
E T
ET
Flad
H D
HD
D000276:Adjuvants, Immunologic; D002240:Carbohydrate Sequence; D002448:Cell Adhesion; D007375:Interleukin-1 / Q000096:biosynthesis; D008050:Lipid A / Q000276:immunology / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D008969:Molecular Sequence Data
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D008050:Lipid A; D008070:Lipopolysaccharides