Non-M CK--a practical measure of creatine kinase isoenzymes in cancer patients.
The individual creatinine kinase (CK) isoenzymes CK-BB and CK-Macro II have previously been investigated as potential tumour markers. We believe there is a need for a system to measure those CK forms not usually present in serum. We have studied a CK-MB immunoinhibition kit which measures all residual CK activity following inactivation of M-subunit activity. In 162 patients with cancer we found no difference in grading (+ or -) between detailed isoenzyme studies and the simple non-M assay. In 33 samples with elevated non-M CK, detailed analysis showed BB alone (45%), Macro II alone (9%), or both (36%). Raised activities were mainly found in patients with small cell lung cancer (SCLC) (17/40; 43%) and GI Tumours (6/11; 55%). In patients with SCLC, elevated activities were associated with disseminated disease. Preliminary evidence indicates that Non-M CK may also be a simple means of monitoring initial treatment response.
McGing
P G
PG
Department of Biochemistry, Mater Hospital, Dublin, Ireland.
Teeling
M
M
McCann
A
A
Kyne
F
F
Carney
D N
DN
D014408:Biomarkers, Tumor / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D009369:Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase