title: A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals.
abstract: The family history method was used to obtain developmental, social, and psychiatric histories on the 67 adult siblings of 37 autistic probands. Two of 67 siblings (3.0%) were autistic, three siblings (4.4%) had severe social dysfunction and isolation, 10 (15%) had cognitive disorders, and 10 (15%) had received treatment for affective disorder. This study is the first to investigate the frequency of disorders in the adult siblings of autistic probands. These results suggest aggregation of a variety of neuropsychiatric disorders in the siblings of autistic individuals.
authors.affiliation: Department of Psychiatry, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
authors.forename: J
authors.initials: J
authors.lastname: Piven
authors.forename: J
authors.initials: J
authors.lastname: Gayle
authors.forename: G A
authors.initials: GA
authors.lastname: Chase
authors.forename: B
authors.initials: B
authors.lastname: Fink
authors.forename: R
authors.initials: R
authors.lastname: Landa
authors.forename: M M
authors.initials: MM
authors.lastname: Wzorek
authors.forename: S E
authors.initials: SE
authors.lastname: Folstein
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D007360:Intelligence; D008297:Male; D019965:Neurocognitive Disorders / Q000235:genetics*; D012307:Risk Factors; D012917:Social Adjustment