Central effect of yohimbine on sexual behavior in the rat.
A large range of doses of yohimbine (Y) was administered intracerebroventricularly (ICV) (5-100 micrograms/rat) or intraperitoneally (IP) (0.35-10 mg/kg) to male rats and the effects on sexual, locomotor and general behavior were evaluated. For both routes there was a clear-cut inverted-U effect (stimulating/depressing), calculable as parabolic regressions on the log of administered doses. The maximal stimulating doses (15 micrograms/rat ICV and 1 mg/kg IP) significantly shortened mount, intromission and ejaculation latencies and the mean interintromission interval. These data indicate the importance of CNS mechanisms in the sexual effect of Y.
Sala
M
M
Institute of Pharmacology, Faculty of Sciences, University of Milan, Italy.
Braida
D
D
Leone
M P
MP
Calcaterra
P
P
Monti
S
S
Gori
E
E
D000818:Animals; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D015016:Yohimbine / Q000008:administration & dosage* / Q000494:pharmacology
D015016:Yohimbine