title: Blood kinetics of sulfamonomethoxine and oxytetracycline following intrauterine spray injection in dairy cows.
abstract: Intrauterine administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics. Sulfamonomethoxine levels were determined by a reversed-phase HPLC method, whilst oxytetracycline quantities were detected by a microbiological method. The sulphonamide had a peak 1.17 h after the administration, the tetracycline reached its highest concentration after 8 h. The bioavailability of both drugs was low and detectable drug amounts were no longer recovered after 24 h.
authors.affiliation: Dipartimento di Patologia Animale, Università di Torino, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Girardi
authors.forename: G
authors.initials: G
authors.lastname: Re
authors.forename: A M
authors.initials: AM
authors.lastname: Farca
authors.forename: M
authors.initials: M
authors.lastname: Dacasto
authors.forename: E
authors.initials: E
authors.lastname: Ferrero
authors.forename: M
authors.initials: M
authors.lastname: Eandi
mesh_terms: D000818:Animals; D001682:Biological Availability; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007267:Injections; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet; D013422:Sulfamonomethoxine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013424:Sulfanilamides / Q000493:pharmacokinetics*; D014599:Uterus
chemical_list: D013424:Sulfanilamides; D013422:Sulfamonomethoxine; D010118:Oxytetracycline