Amperozide and emotional behaviour.
The new putatively antipsychotic drug amperozide is characterized pharmacologically by a specific limbic mode of action. Thus amperozide is a potent antagonist of muricidal behaviour (ED50 = 0.16 mg/kg) as well as aggression between isolated male mice. Although amperozide displays anxiolytic properties in Vogel's conflict test as well as an antidepressive effect in the despair test, the drug does not interfere with motor coordination or cause sedation (ED50 greater than 50 mg/kg). These results could make amperozide very interesting as an antipsychotic drug in the clinic, with effect on both positive and negative symptoms.
Gustafsson
B
B
Dept of CNS-research, Pharmacia LEO Therapeutics AB, Malmö, Sweden.
Christensson
E
E
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001763:Blepharoptosis / Q000139:chemically induced; D003220:Conflict, Psychological; D003863:Depression / Q000523:psychology; D004644:Emotions / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D013550:Swimming
D010879:Piperazines; D011619:Psychotropic Drugs; C049058:amperozide; D006916:5-Hydroxytryptophan