title: Refractory congestive heart failure after ribavirin in infants with heart disease and respiratory syncytial virus.
abstract: Although treatment with ribavirin has been known to be associated with a decreased mortality in infants with congenital heart disease (CHD) who have respiratory syncytial virus (RSV), few data are available regarding morbidity. We reviewed records of 10 consecutively hospitalized infants with CHD during a recent RSV epidemic. Despite the presence of left-to-right shunt in each patient, symptoms of RSV were respiratory at presentation. After ribavirin, decreased respiratory symptoms were found in 8 infants but in 2 assisted ventilation were required 1 and 3 days after admission. Congestive heart failure worsened in 8 patients, 6 of whom had improved respiratory status after ribavirin. Of the 8 patients with worse CHF (pulmonary edema), 3 responded to medical management but 5 were refractory and 4 required surgical repair of CHD. One patient died of pulmonary hemorrhage. Medically refractory CHF may develop in infants with CHD who become infected with RSV and are treated with ribavirin. Further studies are needed to determine whether the pulmonary edema is caused by RSV, ribavirin, or combination of effects on pulmonary capillary function or some other unrecognized mechanism.
authors.affiliation: Department of Pediatrics (Section of Cardiology), University of Nebraska Medical Center, Omaha 68105.
authors.forename: J T
authors.initials: JT
authors.lastname: Martin
authors.forename: J D
authors.initials: JD
authors.lastname: Kugler
authors.forename: C H
authors.initials: CH
authors.lastname: Gumbiner
authors.forename: J C
authors.initials: JC
authors.lastname: Brown
authors.forename: K R
authors.initials: KR
authors.lastname: Murphy
authors.forename: J L
authors.initials: JL
authors.lastname: Colombo
authors.forename: B M
authors.initials: BM
authors.lastname: McManus
mesh_terms: D006330:Heart Defects, Congenital / Q000150:complications* / Q000401:mortality; D006333:Heart Failure / Q000150:complications* / Q000401:mortality; D006343:Heart Septal Defects / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012136:Respiratory Syncytial Viruses; D010253:Respirovirus Infections / Q000150:complications / Q000188:drug therapy*; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
chemical_list: D012263:Ribonucleosides; D012254:Ribavirin