A dose-response study of UVB-induced suppression of contact photosensitivity in the mouse.
A marked contact photosensitivity (CPS) response to 3,3',4',5 tetrachlorosalicylanilide (TCSA) plus UVA was induced in mice. Cyclophosphamide (Cy), given prior to sensitization, caused a further increase in ear swelling. When UVB radiation was given at a site distant from that used for sensitization it caused a dose-related suppression of CPS. Cy did not eliminate the UVB-induced suppression.
Shivji
G M
GM
University of Toronto, Division of Dermatology, Canada.
Brown
W R
WR
Ramsay
C A
CA
D000485:Allergens / Q000276:immunology*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010787:Photosensitivity Disorders / Q000532:radiotherapy*; D012457:Salicylamides / Q000276:immunology*; D012458:Salicylanilides / Q000276:immunology*; D014467:Ultraviolet Therapy
D000485:Allergens; D012457:Salicylamides; D012458:Salicylanilides; D003520:Cyclophosphamide; C003390:3,3',4',5-tetrachlorosalicylanilide