title: Impairment of theophylline clearance by a hypocaloric low-protein diet in chronic obstructive pulmonary disease.
abstract: The effect of a hypocaloric, low protein diet on theophylline kinetics was studied in a 70-year-old man with chronic obstructive pulmonary disease who lost 6.2 kg of weight. Total systemic clearance, unbound clearance, and intrinsic hepatic clearance fell dramatically. Theophylline elimination half-life rose from 8.4 to 17.1 h. Therefore, a diet deficient in both calories and protein can significantly impair theophylline clearance and prolong theophylline elimination half-life.
authors.affiliation: Clinical Research Center, Northwestern Memorial Hospital, Chicago, Illinois.
authors.forename: D
authors.initials: D
authors.lastname: Juan
authors.forename: S G
authors.initials: SG
authors.lastname: Shin
authors.forename: M
authors.initials: M
authors.lastname: Fisher
authors.forename: R L
authors.initials: RL
authors.lastname: Hughes
mesh_terms: D000368:Aged; D004038:Diet, Reducing / Q000009:adverse effects*; D004044:Dietary Proteins / Q000008:administration & dosage*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D013806:Theophylline / Q000493:pharmacokinetics*
chemical_list: D004044:Dietary Proteins; D013806:Theophylline