title: Studies on new dehydropeptidase inhibitors. II. Structural elucidation and synthesis of WS1358A1 and B1.
abstract: The structures of WS1358A1 and B1, new dehydropeptidase inhibitors isolated from Streptomyces parvulus subsp. tochigiensis No. 1358, have been established to be 2-hydroxy-2-hydroxyaminocarbonyl-3-methylglutaric acid (1) and 2-hydroxy-2-hydroxyaminocarbonylglutaric acid (2), respectively, on the basis of spectroscopic evidence and synthesis of the racemates.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takase
authors.forename: I
authors.initials: I
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D004150:Dipeptidases / Q000037:antagonists & inhibitors*; D005977:Glutarates / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000378:metabolism
chemical_list: D005977:Glutarates; C063283:WS 1358A1; C063284:WS 1358B1; D004150:Dipeptidases