Platelet adenylate cyclase and phospholipase C activity in posttraumatic stress disorder.
Adenylate cyclase and phospholipase C activity were examined in platelet membranes obtained from 19 male subjects with combat-related posttraumatic stress disorder (PTSD) and 35 age- and gender-matched healthy controls. Basal and forskolin-stimulated adenylate cyclase activity were significantly lower in the PTSD group whereas aluminum chloride plus sodium fluoride (AlCl3/NaF)- and prostaglandin E1 (PGE1)-stimulated responses were normal. There was no difference in phospholipase C activity between the two groups. The lower basal and forskolin-stimulated adenylate cyclase responses replicate a previous report and suggest that PTSD may be associated with an abnormality of the catalytic subunit of the receptor-adenylate cyclase complex.
Lerer
B
B
Yaacov Herzog Center for Brain and Psychiatry Research, Jerusalem, Israel.
Bleich
A
A
Bennett
E R
ER
Ebstein
R P
RP
Balkin
J
J
D000262:Adenylyl Cyclases / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D003130:Combat Disorders / Q000201:enzymology* / Q000523:psychology; D006801:Humans; D008297:Male; D010556:Personality Tests; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013313:Stress Disorders, Post-Traumatic / Q000201:enzymology*; D010738:Type C Phospholipases / Q000097:blood*; D014728:Veterans / Q000523:psychology*; D014744:Vietnam
D010738:Type C Phospholipases; D000262:Adenylyl Cyclases