title: In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea.
abstract: Tosufloxacin (A-60969 HCl), a new quinolone with broad activity against gram-positive and anaerobic organisms, was compared in vitro with other quinolones against bacterial pathogens of diarrhea. Tosufloxacin was the most active agent against Salmonella spp., Shigella spp., Campylobacter spp., Aeromonas hydrophila, and Vibrio spp. Temafloxacin (A-62254) also demonstrated good activity against these organisms.
authors.affiliation: Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors.forename: J P
authors.initials: JP
authors.lastname: Bryan
authors.forename: C
authors.initials: C
authors.lastname: Waters
authors.forename: J
authors.initials: J
authors.lastname: Sheffield
authors.forename: R E
authors.initials: RE
authors.lastname: Krieg
authors.forename: P L
authors.initials: PL
authors.lastname: Perine
authors.forename: K
authors.initials: K
authors.lastname: Wagner
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003967:Diarrhea / Q000382:microbiology*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines; D015363:Quinolones
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D015363:Quinolones; C054745:temafloxacin; D002939:Ciprofloxacin; C055185:tosufloxacin; C047224:sarafloxacin