title: Effects of experimentally induced Streptococcus suis infection on the pharmacokinetics of penicillin G in pigs.
abstract: The pharmacokinetics of potassium penicillin G were studied in both healthy (n = 8) and experimentally Streptococcus-suis-infected (n = 6) pigs following intramuscular administration (15,000 iu/kg). Streptococcus-suis infection was induced artificially in young cross-bred pigs by subcutaneous inoculation with 9 x 10(8) to 10(9) colony-forming units of S. suis. The rectal temperature of infected pigs was significantly increased (P less than 0.01) before penicillin G injection and this was maintained for 8 h after the drug was given. Other clinical symptoms were also present. The serum concentration-time data for penicillin were found to fit a one-compartment open model with first-order absorption in the two groups of pigs. Significant changes were not observed between healthy and diseased pigs in following parameters: A, Ka, Ke and Tmax. However, in diseased pigs, significant increases (P less than 0.01) were found in Vd and ClB, and significant decreases (P less than 0.01) in Cmax and AUC occurred. The increased body clearance (ClB) and greater apparent volume of distribution (Vd) of penicillin G could partly explain why the serum values of the drug were much lower in diseased pigs than in healthy pigs.
authors.affiliation: Department of Veterinary Medicine, South China Agricultural University, Guangzhou.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Zeng
authors.forename: K F
authors.initials: KF
authors.lastname: Fung
mesh_terms: D000818:Animals; D001831:Body Temperature; D008297:Male; D010400:Penicillin G / Q000097:blood / Q000493:pharmacokinetics*; D013290:Streptococcal Infections / Q000378:metabolism / Q000662:veterinary*; D013291:Streptococcus; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010400:Penicillin G