Reinnervation of the canine posterior cricoarytenoid muscle with sympathetic preganglionic neurons.
This experiment investigated the reinnervation of the canine posterior cricoarytenoid (PCA) muscle with preganglionic neurons of the sympathetic nervous system. Six dogs had their right recurrent laryngeal nerve (RLN) sectioned. Four of these dogs had the sympathetic cervical trunk (SCT) implanted into the right PCA muscle, and the two remaining dogs served as denervated controls. Four months later all dogs underwent videolaryngoscopy, electromyography, and electrical stimulation of the SCT. The PCA muscles were excised, sectioned, and stained for glycogen and ATPase. All four experimental PCA muscles demonstrated electrically evoked abduction and tonic electromyographic activity. In two of the specimens, staining (ATPase and PAS) revealed areas of reinnervation with fiber type grouping and glycogen depletion. These results are consistent with the successful reinnervation of the PCA muscle. Further refinement of this technique could be of benefit to patients with bilateral vocal cord paralysis.
Jacobs
I N
IN
Department of Otolaryngology, Mount Sinai Medical Center, New York, New York.
Sanders
I
I
Wu
B L
BL
Biller
H F
HF
D000320:Adrenergic Fibers / Q000637:transplantation*; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000637:transplantation*; D004285:Dogs; D004558:Electric Stimulation; D004576:Electromyography; D007821:Laryngeal Muscles / Q000294:innervation* / Q000473:pathology / Q000502:physiology; D007828:Laryngoscopy; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation*; D012009:Recurrent Laryngeal Nerve / Q000601:surgery; D061226:Recurrent Laryngeal Nerve Injuries; D014827:Vocal Cords / Q000502:physiology