title: Preliminary trials using a macrocyclic lactone against psoroptic scabies of cattle.
abstract: A macrocyclic lactone, LL-F28249 alpha, C36H52O8, was evaluated as a one- or two-injection treatment in different formulations and concentrations against cattle infested with Psoroptes ovis (Hering). One injection of 2 mg kg-1 or two injections of 1 mg kg-1 of 3% active material in either an aqueous or oil formulation failed to eliminate all of the mites. A single injection of 3 mg kg-1 as a 5% aqueous formulation eliminated all mites for 35 days post-injection. At lower dosages of the aqueous formulation (3%), the male mites appeared to be less susceptible to the acaricide than either the female or immature mites.
authors.affiliation: U.S. Department of Agriculture, Knipling-Bushland U.S. Livestock Insects Research Laboratory, Kerrville, TX 78029-0232.
authors.forename: F C
authors.initials: FC
authors.lastname: Wright
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation
chemical_list: D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; C056041:nemadectin