title: Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.
abstract: 1. The existence of an intermediate pool of ubiquinone in intact mitochondria of rat heart was investigated. 2. The incorporation of [3H-methyl]S-adenosylmethionine into ubiquinone-9 was not influenced by the co-synthesis of the intermediate, 3-nonaprenyl-4-hydroxybenzoate. 3. In the intermediate-depleted mitochondria, the synthetic rate of the intermediate, 3-nonaprenyl-4-hydroxybenzoate was similar to that of ubiquinone. 4. The possible existence of 3-nonaprenyl-4-hydroxybenzoate as a metabolic pool under physiological condition is discussed.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Sugawara
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Momose
mesh_terms: D000818:Animals; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D011106:Polyisoprenyl Phosphates; D013729:Terpenes; D014451:Ubiquinone; C008665:3-nonaprenyl-4-hydroxybenzoate; C063778:solanesyl pyrophosphate; D012436:S-Adenosylmethionine