title: HLA antigens in Greek patients with cholelithiasis.
abstract: The distribution of HLA-A and B antigens was studied in 100 patients with cholelithiasis and in 202 healthy individuals all of Greek origin. An increased frequency of HLA-Aw19 was found in patients (33 per cent) compared with controls (22 per cent) (p less than 0.05, RR 1.7). The increase of Aw19 was even higher for patients with a family history of the disease (44 per cent, vs 22 per cent, p less than 0.01, RR 2.7) and for patients with cholesterol gall stones (44 per cent vs 22 per cent, p less than 0.01, RR 2.5). No difference was seen in patients without a family history of disease or with mixed gall stones. These results suggest a genetic basis for the development of cholesterol gall stone disease.
authors.affiliation: Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Papasteriades
authors.forename: I
authors.initials: I
authors.lastname: al-Mahmoud
authors.forename: N
authors.initials: N
authors.lastname: Papageorgakis
authors.forename: S
authors.initials: S
authors.lastname: Romania
authors.forename: A
authors.initials: A
authors.lastname: Katsas
authors.forename: W
authors.initials: W
authors.lastname: Ollier
authors.forename: I
authors.initials: I
authors.lastname: Economidou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis*; D002769:Cholelithiasis / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D006115:Greece; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D006680:HLA Antigens; D015234:HLA-A Antigens; C043205:HLA-A19 antigen; D002784:Cholesterol