title: The efficacy of triclabendazole and other anthelmintics against Fasciola hepatica in controlled studies in cattle.
abstract: In eight controlled tests 274 cattle were used to assess the efficacies of triclabendazole, albendazole, clorsulon, nitroxynil, oxyclozanide and rafoxanide against Fasciola hepatica. Against one-, two- and four-week-old early immature fluke the mean efficacies of triclabendazole given orally at 12 mg/kg were 88.1, 95.3 and 90.7 per cent, respectively. Clorsulon, nitroxynil and rafoxanide administered at recommended dose rates showed negligible activity against these stages of the parasite. Against six- and eight-week-old infections the mean efficacies of triclabendazole at 12 mg/kg were 87.5 per cent and 95.7 per cent, respectively. Against F hepatica aged six weeks, albendazole and oxyclozanide showed no activity and clorsulon, nitroxynil and rafoxanide had only slight to moderate activity. The efficacies of triclabendazole, clorsulon, nitroxynil and rafoxanide against 10- or 12-week-old parasites were 100, 99.0, 99.1 and 90.1 per cent, respectively. Albendazole and oxyclozanide showed poor efficacy against 12-week-old infections.
authors.affiliation: Ciba-Geigy Ltd, Basle, Switzerland.
authors.forename: R J
authors.initials: RJ
authors.lastname: Richards
authors.forename: F L
authors.initials: FL
authors.lastname: Bowen
authors.forename: F
authors.initials: F
authors.lastname: Essenwein
authors.forename: R F
authors.initials: RF
authors.lastname: Steiger
authors.forename: G
authors.initials: G
authors.lastname: Büscher
mesh_terms: D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004351:Drug Resistance; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D009611:Nitroxinil / Q000008:administration & dosage / Q000494:pharmacology; D010097:Oxyclozanide / Q000008:administration & dosage / Q000494:pharmacology; D010270:Parasite Egg Count / Q000662:veterinary; D011888:Rafoxanide / Q000008:administration & dosage / Q000494:pharmacology; D013424:Sulfanilamides / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D000077682:Triclabendazole
chemical_list: D001562:Benzimidazoles; D013424:Sulfanilamides; D010097:Oxyclozanide; D011888:Rafoxanide; D000077682:Triclabendazole; D009611:Nitroxinil; C015675:clorsulon; D015766:Albendazole