Haircell forward and reverse transduction: differential suppression and enhancement.
Cochlear outer haircells are believed to play a significant role in an amplification process which greatly enhances inner ear sensitivity. Haircell forward (mechanical-to-electrical) and reverse (electrical-to-mechanical) transduction may be involved. We have produced decreases in cochlear microphonic and increases in electrically-evoked cochlear emissions using the drug, furosemide. The data indicate forward and reverse transduction are not a simple bi-directional process and suggest that the outer haircells are part of a negative feedback system.
Hubbard
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AE
Boston University College of Engineering, MA 02215.
Mountain
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DC
D000818:Animals; D001696:Biomechanical Phenomena; D003051:Cochlea / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D004711:Endolymphatic Duct / Q000502:physiology; D005665:Furosemide / Q000494:pharmacology; D005849:Gerbillinae; D006198:Hair Cells, Auditory / Q000502:physiology*; D015398:Signal Transduction; D013016:Sound
D005665:Furosemide