title: Monosomy 3 and isochromosome 8q in a uveal melanoma.
abstract: Chromosome analysis of a locally invasive uveal melanoma revealed monosomy 3 and i(8q). Sublines with multiple copies of the i(8q) were also present. Loss of heterozygosity for genes on chromosome 3 and duplication of genes on 8q may play an important role in progression of uveal melanoma.
authors.affiliation: Department of Pathology, Vancouver General Hospital, B. C., Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Horsman
authors.forename: H
authors.initials: H
authors.lastname: Sroka
authors.forename: J
authors.initials: J
authors.lastname: Rootman
authors.forename: V A
authors.initials: VA
authors.lastname: White
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D005810:Multigene Family; D014604:Uveal Neoplasms / Q000235:genetics*