title: Long-term results with the above-knee popliteal expanded polytetrafluoroethylene graft.
abstract: Since approximately 30% to 40% of autogenous vein bypass grafts to the femoropopliteal level may occlude within 5 years of implantation, additional vein will be required for subsequent revisions. We undertook a study to determine whether the preferential use of an above-knee expanded polytetrafluoroethylene bypass graft to save vein is an appropriate option. We reviewed our experience with 114 above-knee expanded polytetrafluoroethylene bypass reconstructions. Life-table analysis of primary and secondary graft patency was carried out by the method of Peto and statistically analyzed for the influence of clinical indication, runoff as determined by both preoperative and intraoperative completion arteriography, smoking, and diabetes. The 5-year primary patency rate of 57% for patients with claudication was comparable to contemporary randomized or retrospective series with below-knee autogenous vein for that indication, and it was superior to the patency rate for limb salvage. The status of the runoff vessels was an important determinant of outcome. The 59 limbs with good arteriographic runoff (2 to 3 vessels) had a markedly higher 5-year patency rate (70%) than the poor arteriographic runoff (0 to 1 vessels) group (30%). Continued cigarette smoking and diabetes mellitus also appeared to affect adversely primary graft patency in our hands. Our data support the use of preferential above-knee expanded polytetrafluoroethylene grafts in patients with good angiographic runoff. This approach does not appear to prejudice the limb against secondary revisionary procedures or the use of a new autogenous graft, if required.
authors.affiliation: Department of Surgery, New England Medical Center, Boston, MA 02111.
authors.forename: E J
authors.initials: EJ
authors.lastname: Prendiville
authors.forename: A
authors.initials: A
authors.lastname: Yeager
authors.forename: T F
authors.initials: TF
authors.lastname: O'Donnell
authors.forename: J C
authors.initials: JC
authors.lastname: Coleman
authors.forename: A
authors.initials: A
authors.lastname: Jaworek
authors.forename: A D
authors.initials: AD
authors.lastname: Callow
authors.forename: W C
authors.initials: WC
authors.lastname: Mackey
authors.forename: R A
authors.initials: RA
authors.lastname: Deterling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001807:Blood Vessel Prosthesis; D005260:Female; D006083:Graft Occlusion, Vascular / Q000453:epidemiology; D006439:Hemodynamics; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000453:epidemiology; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011150:Popliteal Artery / Q000601:surgery*; D012907:Smoking / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000453:epidemiology; D014654:Vascular Patency
chemical_list: D011138:Polytetrafluoroethylene