title: Intranodal myofibroblastoma presenting in the submandibular region: evidence of a broader clinical and histological spectrum.
abstract: Intranodal myofibroblastoma is an uncommon benign mesenchymal tumour of lymph nodes which was first described in May 1989. All the cases described to date have presented exclusively in the groin, a feature which has been regarded as distinctive. Two new cases are presented herein, both of which arose in the submandibular region of middle-aged females. Both lesions showed histological features marginally different from the cases originally described, which may reflect their different anatomical location. Immunohistochemical staining revealed positivity for muscle-specific actin (HHF 35), as previously described, and ultrastructural examination in one case confirmed the presence of myofibroblasts. The data presented suggest that this distinctive lesion has a broader clinicopathological spectrum than previously realised.
authors.affiliation: Department of Histopathology, St Thomas's Hospital Medical School (UMDS), London, UK.
authors.forename: C D
authors.initials: CD
authors.lastname: Fletcher
authors.forename: R W
authors.initials: RW
authors.lastname: Stirling
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D009442:Neurilemmoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery