Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter.
A sequential pattern of interactions of trans-acting factors in rat liver with the phosphoenolpyruvate carboxykinase promoter during late development was observed. A liver-enriched factor, possibly AF1, interacted with the promoter in fetal liver, whereas a factor with the characteristics of C/EBP bound the promoter after birth with the onset of the gene expression.
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Department of Developmental Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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Cohen
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Reshef
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D000367:Age Factors; D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D008099:Liver / Q000254:growth & development / Q000502:physiology*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000502:physiology*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics*; D011401:Promoter Regions, Genetic; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
D009687:Nuclear Proteins; D014157:Transcription Factors; D010729:Phosphoenolpyruvate Carboxykinase (GTP)