Synthesis and characterization of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids.
The preparation of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids (harmaline, harmalol, harmine, and harmane) is described. These complexes, characterized on the basis of their CHN elemental analysis, infrared, Raman and 1H and 13C nuclear resonance spectral data, were shown to have the empirical formula [M(alkaloid)Cl2], M = Pt, Pd. The antitumor and antiviral activities of some of these complexes have been demonstrated.
Al-Alaf
T A
TA
Chemistry Department, College of Science, University of Mosul, Iraq.
Ayoub
M T
MT
Rashan
L J
LJ
D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002243:Carbolines / Q000138:chemical synthesis; D006246:Harmaline / Q000031:analogs & derivatives / Q000032:analysis / Q000494:pharmacology; D006247:Harmine / Q000031:analogs & derivatives / Q000032:analysis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis; D009944:Organoplatinum Compounds; D010165:Palladium; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002243:Carbolines; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; C007904:harmalol; D006247:Harmine; D010165:Palladium; C005010:harman; D006246:Harmaline