title: [Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease].
abstract: Apomorphine, a dopaminergic agonist was given over a period of 12 months to 14 parkinsonian patients suffering from severe L-dopa induced on-off effects. Nine patients (mean age: 52 years; mean age at onset of the disease: 37 years), were treated by continuous infusion with a portable minipump, and 5 others by multiple injections with a penject. The mean duration of daily off periods was reduced by two thirds in all patients. The motor fluctuation intensity was only diminished in the 9 patients treated by continuous infusion. These patients received a mean apomorphine daily dose of 93 mg and L-dopa dosage was reduced by 53 p. 100. Red fibrous subcutaneous nodules occurred at the injection sites in all patients treated by infusion. This study confirms the effectiveness of subcutaneous apomorphine administration in the treatment of severe motor fluctuations.
authors.affiliation: Département des Neurosciences Cliniques et Biologiques, Universitaire de Grenoble.
authors.forename: P
authors.initials: P
authors.lastname: Pollak
authors.forename: A S
authors.initials: AS
authors.lastname: Champay
authors.forename: J M
authors.initials: JM
authors.lastname: Gaio
authors.forename: M
authors.initials: M
authors.lastname: Hommel
authors.forename: A L
authors.initials: AL
authors.lastname: Benabid
authors.forename: J
authors.initials: J
authors.lastname: Perret
mesh_terms: D000328:Adult; D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007279:Injections, Subcutaneous; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D011596:Psychomotor Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D007980:Levodopa; D001058:Apomorphine
vernacular_title: Administration sous-cutanée d'apomorphine dans les fluctuations motrices de la maladie de Parkinson.