Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent.
We have applied a superparamagnetic iron oxide formulation (AMI-25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast-enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities.
Kent
T A
TA
Department of Neurology, University of Texas Medical Branch, Galveston 77550.
Quast
M J
MJ
Kaplan
B J
BJ
Lifsey
R S
RS
Eisenberg
H M
HM
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005069:Evaluation Studies as Topic; D005290:Ferric Compounds; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide