title: [Acute lymphoblastic leukemia: clinical data and results of intensive chemotherapy].
abstract: Twenty-one children, between eight months and twelve years old, diagnosed as having acute nonlymphoblastic leukemia (ANLL), were treated with an intensive chemotherapy based on a modified VAPA protocol. Complete remission rate was 80%, and the 5 year-survival rate is 46%. One chloroma, one central nervous system, and four bone marrow relapses were observed; all except the first having an unfavourable outcome. Significant risk prognostic factors in this series proved to be hepatomegaly (greater than 5 cm) and delay in obtaining remission. No fatal complications were observed.
authors.affiliation: Unidad de Oncologia Pediátrica del Hospital Infantil La Fe, Valencia.
authors.forename: J G
authors.initials: JG
authors.lastname: Ruiz Soler
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández Navarro
authors.forename: A
authors.initials: A
authors.lastname: Verdeguer Miralles
authors.forename: C
authors.initials: C
authors.lastname: Esquembre Menor
authors.forename: J
authors.initials: J
authors.lastname: Ferris Tortajada
authors.forename: V
authors.initials: V
authors.lastname: Castel Sánchez
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D011379:Prognosis; D012074:Remission Induction
vernacular_title: Leucemia no linfoblástica aguda: datos clínicos y resultados de una quimioterapia intensiva.