title: Successful treatment of malignant external otitis with oral ciprofloxacin: report of experience with 23 patients.
abstract: Twenty-three consecutive patients with malignant external otitis (MEO) were treated with oral ciprofloxacin, 1.5-2.25 g/day for 6 weeks. Treatment was combined with local surgical debridement. Patients were discharged early for ambulatory follow-up. Few minor side effects were reported, and full compliance with the study drug was observed. In 21 patients cure was achieved; in 2 the response was not adequate. Oral ciprofloxacin is an effective, convenient, nontoxic, economically justified alternative to the combination intravenous therapy previously advocated.
authors.affiliation: Infectious Diseases Unit, Meir Hospital, Kfar-Saba, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Lang
authors.forename: S
authors.initials: S
authors.lastname: Goshen
authors.forename: R
authors.initials: R
authors.lastname: Kitzes-Cohen
authors.forename: J
authors.initials: J
authors.lastname: Sadé
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010032:Otitis Externa / Q000188:drug therapy* / Q000601:surgery; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000601:surgery
chemical_list: D002939:Ciprofloxacin