Fulminant hepatic failure in poisoning due to ingestion of T 61, a veterinary euthanasia drug.
A patient developed fulminant hepatic failure 48 h after the ingestion of T 61, a veterinary euthanasia drug which contains both general and local anesthetics, a neuromuscular blocking agent, and dimethylformamide (DMF) as a solvent. This is the first report of such severe hepatic manifestation in T 61 poisoning, the most common symptoms of which are early coma and respiratory failure due to the anesthetic and the neuromuscular blocking agent. In a very few cases mild and transitory symptoms of hepatic insufficiency have been observed. In this case the fulminant hepatic failure was due to the high dose (0.6 ml/kg) ingestion of DMF.
Nicolas
F
F
Department of Intensive Care, Centre Hospitalier Universitaire, Nantes, France.
Rodineau
P
P
Rouzioux
J M
JM
Tack
I
I
Chabac
S
S
Meram
D
D
D000577:Amides; D000641:Ammonia / Q000097:blood; D004126:Dimethylformamide / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D062787:Drug Overdose / Q000150:complications* / Q000628:therapy; D005260:Female; D006501:Hepatic Encephalopathy / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D010976:Platelet Count; D000644:Quaternary Ammonium Compounds; D013406:Suicide, Attempted; D013748:Tetracaine
D000577:Amides; D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; D013748:Tetracaine; C015591:T 61; D000641:Ammonia; D004126:Dimethylformamide