Measurement of ethanol in the human brain using NMR spectroscopy.
Ethanol in the human brain is readily observable by noninvasive 1H NMR spectroscopy. We have made such observations in a human subject with a time resolution per measurement of 6.5 min and volume resolution of 16 cc. The ethanol methyl proton signal is well separated from signals of other metabolites in 1H spectra from human brain and it is one of the most intense signals in such spectra when blood ethanol concentration is 0.1% (21.7 mM)--the legal definition of alcoholic intoxication in many jurisdictions. These properties, plus the fact that the ethanol signal can be further isolated from other resonances by spectral editing, open several possibilities for further investigation.
Hanstock
C C
CC
Department of Applied Sciences in Medicine, University of Alberta, Edmonton, Canada.
Rothman
D L
DL
Shulman
R G
RG
Novotny
E J
EJ
Petroff
O A
OA
Prichard
J W
JW
D000435:Alcoholic Intoxication / Q000175:diagnosis*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D000431:Ethanol / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000431:Ethanol