Induction of eosinophilic colonies by interleukin-5 on acute myeloblastic leukaemic cells.
The effect of interleukin-5 (IL-5) on blast colony formation of acute myeloblastic leukaemia (AML) cells was studied. IL-5 showed a weak but significant colony stimulatory effect in one out of six cases studied. IL-5 induced eosinophilic colony growth in this case, and chromosomal and histochemical analyses strongly suggested that these eosinophilic colonies were derived from leukaemic blast progenitor cells. To our knowledge, this is the first report that IL-5 induces eosinophilic colonies on fresh AML cells. A possible induction of differentiation of AML blast cells by IL-5 is suggested.
Motoji
T
T
Department of Medicine, Tokyo Women's Medical College, Japan.
Okada
M
M
Takanashi
M
M
Masuda
M
M
Tanaka
K
K
Oshimi
K
K
Mizoguchi
H
H
D000328:Adult; D000368:Aged; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000494:pharmacology*; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells; D014410:Tumor Stem Cell Assay
D003115:Colony-Stimulating Factors; D015848:Interleukin-5