title: Peripheral nerve section induces increased levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity in axotomized motoneurons.
abstract: By use of fluorescence immunohistochemistry it is shown that sciatic nerve section in cat and rat induces increased levels of immunoreactive calcitonin gene-related peptide (CGRP) in axotomized motoneurons. In the rat, this effect was clearly seen at 2-5 days postoperatively, but could not be demonstrated after 11-21 days. These findings are discussed in relation to previously proposed roles for CGRP in motoneurons.
authors.affiliation: Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Arvidsson
authors.forename: H
authors.initials: H
authors.lastname: Johnson
authors.forename: F
authors.initials: F
authors.lastname: Piehl
authors.forename: S
authors.initials: S
authors.lastname: Cullheim
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
authors.forename: M
authors.initials: M
authors.lastname: Risling
authors.forename: L
authors.initials: L
authors.lastname: Terenius
authors.forename: B
authors.initials: B
authors.lastname: Ulfhake
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002415:Cats; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology*
chemical_list: D015740:Calcitonin Gene-Related Peptide