The effect of hypermagnesemia on serum levels of osteocalcin in an animal model.
Using a pregnant goat (Capra hircus) model to study the in vivo effects of hypermagnesemia on serum osteocalcin concentration, magnesium sulfate infusion has been shown to increase circulating levels of osteocalcin. At 2 h after the administration of magnesium sulfate, a 98% increase in Mg2+ concentration over the basal level resulted in: a 38% increase in serum osteocalcin concentration over baseline; a 22% decrease in PTH concentration, and no change in total and ionized calcium concentrations. These in vivo data support previous in vitro results demonstrating that Mg2+ is a potent inhibitor of osteocalcin binding to hydroxyapatite.
Wians
F H
FH
Department of Pathology, Wilford Hall USAF Medical Center, Lackland AFB, Tex.
Strickland
D M
DM
Hankins
G D
GD
Snyder
R R
RR
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006041:Goats; D006706:Homeostasis; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008954:Models, Biological; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000378:metabolism; D011247:Pregnancy
D010281:Parathyroid Hormone; D015675:Osteocalcin; D008278:Magnesium Sulfate; D002118:Calcium