title: [Functional and morphological characterization of alveolar macrophages from patients with pulmonary sarcoidosis].
abstract: Bronchoalveolar lavage was performed in 28 patients with pulmonary sarcoidosis. Enzyme cytochemical staining with the tartrate-resistant acid phosphatase revealed a significantly increased portion of sarcoidosis macrophages showing a monocyte-like phenotype. Immunocytochemical staining with the proliferation-associated monoclonal antibody Ki-67 showed an increase of proliferating monocyte/macrophages related to disease activity in sarcoidosis. A functional activation of alveolar macrophages in sarcoidosis is indicated by spontaneous interleukin-1 secretion and increased release of oxygen free radical in sarcoidosis alveolar macrophages.
authors.affiliation: I. Medizinische Klinik der Universität Kiel.
authors.forename: J
authors.initials: J
authors.lastname: Barth
authors.forename: W
authors.initials: W
authors.lastname: Petermann
authors.forename: H
authors.initials: H
authors.lastname: Kreipe
authors.forename: H J
authors.initials: HJ
authors.lastname: Radzun
authors.forename: M R
authors.initials: MR
authors.lastname: Parwaresch
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002455:Cell Division; D005609:Free Radicals; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000096:biosynthesis; D008171:Lung Diseases / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D010084:Oxidation-Reduction; D012507:Sarcoidosis / Q000276:immunology*
chemical_list: D005609:Free Radicals; D007375:Interleukin-1
vernacular_title: Funktionelle und morphologische Charakterisierung von Alveolarmakrophagen bei Patienten mit pulmonaler Sarkoidose.