Gangliosides enhance the anti-immobility response elicited by several antidepressant treatments in mice.
Ganglioside pretreatment enhanced the anti-immobility effect induced in the forced swim test after a chronic treatment with desipramine, mianserin, clomipramine, nialamide or repeated electroconvulsive shock in mice. Gangliosides, which had no effect per se, showed a clear dose-response relationship in enhancing the anti-immobility effect of desipramine. These results suggest that, regardless of their mechanisms of action, gangliosides facilitate the behavioral response of several antidepressant treatments.
Córdoba
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NE
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Basso
A M
AM
Molina
V A
VA
Orsingher
O A
OA
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D005732:Gangliosides / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009526:Nialamide / Q000494:pharmacology
D000928:Antidepressive Agents; D005732:Gangliosides; D008803:Mianserin; D002997:Clomipramine; D009526:Nialamide; D003891:Desipramine; D006221:Halothane