title: FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
abstract: FR109615, a new antibiotic active against Candida, was isolated from Streptomyces setonii No. 7562. Based on the spectroscopic data, the structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid (1). The compound showed the excellent in vivo efficacy in a generalized infection test of mice.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: E
authors.initials: E
authors.lastname: Tsujii
authors.forename: M
authors.initials: M
authors.lastname: Ezaki
authors.forename: A
authors.initials: A
authors.lastname: Fujie
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Okuhara
authors.forename: M
authors.initials: M
authors.lastname: Kohsaka
authors.forename: H
authors.initials: H
authors.lastname: Imanaka
authors.forename: K
authors.initials: K
authors.lastname: Kawabata
authors.forename: Y
authors.initials: Y
authors.lastname: Inamoto
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy; D003515:Cycloleucine / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology / Q000031:analogs & derivatives; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D003515:Cycloleucine; C065594:cispentacin