[Correlation between intracellular alkaline phosphatase activities and incidence of toxic granules in neutrophilia].
We examined the intracellular alkaline phosphatase (NIAP) activities in peripheral neutrophils in 15 healthy subjects and 15 patients with inflammatory diseases, and compared them with the percentages of neutrophils with cytoplasmic toxic granules (NTG), which is thought to be induced by infection. NIAP activities were markedly increased in patients and significantly correlated with the percentages of NTG. These data indicate that measurement of NIAP activity is useful for the diagnosis of infections and/or inflammatory diseases.
Kabutomori
O
O
Central Laboratory for Clinical Investigation, Osaka University Hospital.
Amino
N
N
Miyai
K
K
Tokuda
M
M
Inaoka
Y
Y
Kawanishi
K
K
D000469:Alkaline Phosphatase / Q000097:blood*; D003594:Cytoplasmic Granules; D005110:Extracellular Space / Q000201:enzymology; D006801:Humans; D007239:Infections / Q000175:diagnosis; D007249:Inflammation / Q000175:diagnosis; D007964:Leukocytosis / Q000201:enzymology* / Q000473:pathology; D009504:Neutrophils / Q000201:enzymology*
D000469:Alkaline Phosphatase