Effects of coenzymes Q2 and Q10 on the field potential of guinea pig olfactory cortex slices maintained in hypoxia.
The effects of exogenous CoQ2 and CoQ10 on field potentials were studied while brain slice preparations of guinea pig olfactory cortex were incubated in hypoxia. The potential amplitude, which diminished in hypoxia, recovered when the slices were superfused with solutions containing CoQ2 and CoQ10. Adenosine triphosphate (ATP) levels in the slices duplicated the experimental results of the potential amplitude. The effects of these ubiquinones on potentials measured in hypoxia were suppressed when the slices were incubated with a barbiturate solution.
Fujii
T
T
Kyoto Municipal Jr. College of Nursing, Japan.
Hayashi
M
M
Toita
K
K
Yamasaki
Y
Y
D000200:Action Potentials / Q000187:drug effects; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D003067:Coenzymes; D006168:Guinea Pigs; D002534:Hypoxia, Brain / Q000503:physiopathology*; D066298:In Vitro Techniques; D009830:Olfactory Bulb / Q000187:drug effects / Q000503:physiopathology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001463:Barbiturates; D003067:Coenzymes; D014451:Ubiquinone; D000255:Adenosine Triphosphate; C024989:coenzyme Q10; C025204:Ubiquinone Q2