Hepatic impairment in fetuses of preeclamptic mothers.
Cord blood from preeclamptic and normal gestations were analyzed for the vitamin K-dependent proteins, factors II, VII, IX, X, and protein C, and for fibrinogen and albumin. Factor II, factor IX, protein C, and albumin protein levels were reduced in the preeclamptic group, whereas there was no significant change in the fibrinogen or factor X protein levels. The data suggest that these findings are probably due to decreased synthesis and are not indicative of vitamin K deficiency.
Lox
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Department of Obstetrics and Gynecology, Texas Technical University, Lubbock.
Harral
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Corrigan
J J
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D000418:Albumins / Q000032:analysis; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005170:Factor X / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000032:analysis / Q000276:immunology; D005333:Fetus / Q000503:physiopathology*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D011486:Protein C / Q000032:analysis; D011516:Prothrombin / Q000032:analysis
D000418:Albumins; D011486:Protein C; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D005340:Fibrinogen