title: Diclazuril, a new broad-spectrum anticoccidial for chickens. 3. Floor-pen trials.
abstract: Diclazuril is a benzeneacetonitrile showing great promise as a broad-spectrum anticoccidial agent for chickens, turkeys, and rabbits. The high anticoccidial activity of diclazuril in chickens, as first reported in dose-titration studies and battery trials, was confirmed in three floor-pen trials. The efficacy was demonstrated against six major pathogenic species of Eimeria after artificial infection with one or more species. The experimental data indicated that diclazuril, at dose levels of .5, .75, 1, and 2 ppm, had a high anticoccidial activity in terms of preventing mortality, suppressing or reducing lesion scores, and allowing for normal weight gains as well as productivity. The performances obtained with diclazuril was generally comparable with that of salinomycin at 60 ppm and that of lasalocid at 90 ppm.
authors.affiliation: Janssen Pharmaceutica, Beerse, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Vanparijs
authors.forename: R
authors.initials: R
authors.lastname: Marsboom
authors.forename: L
authors.initials: L
authors.lastname: Hermans
authors.forename: L
authors.initials: L
authors.lastname: Van der Flaes
mesh_terms: D000818:Animals; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy*; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril