Influence of "nuclear" estrogen receptor content on prognosis of early stage carcinoma of the uterine body. A short-time follow-up.
Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and those with tumors containing greater than 60 fmol ER/mg DNA (p = 0.01). Other prognostic factors showed no differences in frequency of relapses. In this small patient material with a short-time follow-up we therefore suggest that ER in the nuclear pellet may be an important prognostic factor.
Horvath
G
G
Gynecologic Section, University Hospital, Lund, Sweden.
Johnsson
J E
JE
Tropé
C
C
Samuelsson
L
L
Alm
P
P
Olsson
H
H
D000230:Adenocarcinoma / Q000032:analysis* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000032:analysis* / Q000401:mortality
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone