Predictive value of intraoperative liver biopsies of donor organs in patients undergoing orthotopic liver transplantation.
The evaluation of prerevascularization and postrevascularization biopsies in comparison with clinical and laboratory data has revealed a direct correlation between elevated PT and AST levels and pericentral and panlobular individual hepatocyte necrosis. No other significant correlations were determined when comparing selected histologic features to selected clinical laboratory values. In conclusion, these biopsies are of limited use in predicting subsequent allograft function in the absence of prominent individual hepatocyte or pericentral necrosis.
Markin
R S
RS
Department of Pathology & Microbiology, University of Nebraska Medical Center, Omaha 68105-1065.
Wood
R P
RP
Stratta
R J
RJ
Langnas
A N
AN
Pillen
T J
TJ
Dawidson
I
I
Zetterman
R K
RK
Shaw
B W
BW
D000328:Adult; D001706:Biopsy; D002648:Child; D006801:Humans; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D016031:Liver Transplantation / Q000473:pathology*; D009926:Organ Preservation / Q000379:methods; D011379:Prognosis