title: Prenatal and neonatal testosterone exposure interact to affect differentiation of sexual behavior and partner preference in female ferrets.
abstract: Implanting testosterone (T) subcutaneously over Postnatal Days 5-20 masculinized sexual behavior, reduced proceptive responsiveness, and shifted sexual preference more readily in male than in female ferrets gonadectomized on Day 5. This enhanced sensitivity of males to neonatal T was best duplicated in females exposed transplacentally to T over Embryonic Days (E) 27-39 (41-day gestation) and injected at birth with T (2.5 micrograms sc in oil: 10% ethanol). Extended exposure of male ferrets to high levels of T, beginning shortly after the onset of testicular steroidogenesis (E25) and continuing for several hours after birth (E41) normally sensitizes their brains to the subsequent organizational effects on coital performance and sexual motivation of the relatively low levels of T that circulate in male ferrets during the first 3 postnatal weeks.
authors.affiliation: Department of Biology, Boston University, MA 02215.
authors.forename: M J
authors.initials: MJ
authors.lastname: Baum
authors.forename: M S
authors.initials: MS
authors.lastname: Erskine
authors.forename: E
authors.initials: E
authors.lastname: Kornberg
authors.forename: C E
authors.initials: CE
authors.lastname: Weaver
mesh_terms: D000818:Animals; D002335:Carnivora / Q000523:psychology*; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005289:Ferrets / Q000523:psychology*; D005836:Genitalia, Female / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D012733:Sex Differentiation / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects
chemical_list: D004958:Estradiol