title: Recombinant human erythropoietin shortens the uraemic bleeding time without causing intravascular haemostatic activation.
abstract: Blood rheology and haemostasis have been investigated in 8 haemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO). The aim was to elucidate the mechanism by which rHuEPO improves haemostasis, and to determine whether rHuEPO promotes intravascular coagulation. Investigations were performed before, and after 3 months of treatment. Haemoglobin and haematocrit rose significantly after rHuEPO (p less than 0.001) and there was a concurrent shortening of the bleeding time. No significant changes were observed in platelet aggregation, thromboxane generation, or platelet nucleotide content during the treatment period. Whole blood viscosity increased following rHuEPO (p less than 0.01), but plasma viscosity and red cell deformability were unchanged, as were markers of intravascular platelet activation and plasma levels of cross-linked fibrin derivatives. No patient suffered from thrombosis during the study period, and elevation of the haematocrit in uraemic patients up to 0.35 with rHuEPO did not appear to lead to intravascular coagulation. Shortening of the prolonged bleeding time in haemodialyzed patients following rHuEPO appeared to be due to the increase in circulating red cells, rather than to changes in platelet reactivity.
authors.affiliation: Dept. of Renal Medicine, St. Philip's Hospital London, United Kingdom.
authors.forename: M P
authors.initials: MP
authors.lastname: Gordge
authors.forename: B
authors.initials: B
authors.lastname: Leaker
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: E
authors.initials: E
authors.lastname: Oviasu
authors.forename: J S
authors.initials: JS
authors.lastname: Cameron
authors.forename: G H
authors.initials: GH
authors.lastname: Neild
mesh_terms: D000328:Adult; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy
chemical_list: D004921:Erythropoietin