Subarachnoid and epidural calcitonin in patients with pain due to metastatic cancer.
Nine patients with metastatic cancer who had pain refractory to traditional treatments received a subarachnoid injection of salmon calcitonin. Eight of the nine patients reported pain relief after subarachnoid injection varying from 1 hr to 5 days. Four of the responding patients subsequently received an epidural injection of salmon calcitonin, and two of these patients reported pain relief. Although many patients experienced pain relief, nausea and vomiting appeared to be a significant side effect, occurring in seven out of nine patients.
Blanchard
J
J
Menk
E
E
Ramamurthy
S
S
Hoffman
J
J
D015360:Analgesia, Epidural; D002116:Calcitonin / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D006801:Humans; D007278:Injections, Spinal; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy*; D010148:Intractable Pain / Q000188:drug therapy*; D013346:Subarachnoid Space
D002116:Calcitonin