Relaxation response to pinacidil and diazoxide in the mouse isolated distal colon.
Pinacidil and diazoxide induced concentration-related relaxations of the longitudinal muscle of the mouse distal colon. The relaxing effects of pinacidil and diazoxide were unaffected by tetraethylammonium, but were antagonized by tolbutamide and glibenclamide. Relaxations provoked by nifedipine were not counteracted by the two hypoglycaemic sulfonylureas. It is tempting to suggest that the relaxation response to pinacidil and diazoxide could reflect the ability of both compounds to interfere with membrane K+ channels sharing common pharmacological properties with the K+ATP channels recently described in other tissues.
Lebrun
P
P
Laboratory of Pharmacology, Faculty of Medicine and Pharmacy, Free University of Brussels, Belgium.
Fontaine
J
J
D000818:Animals; D003106:Colon / Q000187:drug effects*; D003981:Diazoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000494:pharmacology*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D020110:Pinacidil; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D006146:Guanidines; D013453:Sulfonylurea Compounds; D014665:Vasodilator Agents; D020110:Pinacidil; D003981:Diazoxide