title: Ultrastructural localization of pemphigus vulgaris antigen on canine keratinocytes in vivo and in vitro.
abstract: Pemphigus antigens were localized, by use fo immunoelectron microscopy, on canine keratinocytes in vivo on esophageal mucosa and in vitro on established cultured keratinocytes. Convalescent sera from a human being with pemphigus vulgaris and a human being with pemphigus foliaceus reacted with the interdesmosomal cytoplasmic keratinocyte membrane of canine esophagus. Cultured canine keratinocytes expressed the pemphigus vulgaris antigen in a similar pattern, but did not carry the pemphigus foliaceus antigen. The differential presence of cell surface antigens and its relation to various forms of the disease are discussed.
authors.affiliation: Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: M M
authors.initials: MM
authors.lastname: Suter
authors.forename: J E
authors.initials: JE
authors.lastname: Wilkinson
authors.forename: E P
authors.initials: EP
authors.lastname: Dougherty
authors.forename: R M
authors.initials: RM
authors.lastname: Lewis
mesh_terms: D000818:Animals; D000906:Antibodies; D000941:Antigens / Q000032:analysis*; D004285:Dogs; D004947:Esophagus / Q000276:immunology / Q000648:ultrastructure; D007106:Immune Sera / Q000276:immunology; D015603:Keratinocytes / Q000276:immunology*; D008854:Microscopy, Electron; D010392:Pemphigus / Q000276:immunology*
chemical_list: D000906:Antibodies; D000941:Antigens; D007106:Immune Sera