Reflex control of vascular capacitance during hypoxia, hypercapnia, or hypoxic hypercapnia.
We tested the hypothesis that the changes in venous tone induced by changes in arterial blood oxygen or carbon dioxide require intact cardiovascular reflexes. Mongrel dogs were anesthetized with sodium pentobarbital and paralyzed with veruronium bromide. Cardiac output and central blood volume were measured by indocyanine green dilution. Mean circulatory filling pressure, an index of venous tone at constant blood volume, was estimated from the central venous pressure during transient electrical fibrillation of the heart. With intact reflexes, hypoxia (arterial PaO2 = 38 mmHg), hypercapnia (PaCO2 = 72 mmHg), or hypoxic hypercapnia (PaO2 = 41; PaCO2 = 69 mmHg) (1 mmHg = 133.32 Pa) significantly increased the mean circulatory filling pressure and cardiac output. Hypoxia, but not normoxic hypercapnia, increased the mean systemic arterial pressure and maintained the control level of total peripheral resistance. With reflexes blocked with hexamethonium and atropine, systemic arterial pressure supported with a constant infusion of norepinephrine, and the mean circulatory filling pressure restored toward control with 5 mL/kg blood, each experimental gas mixture caused a decrease in total peripheral resistance and arterial pressure, while the mean circulatory filling pressure and cardiac output were unchanged or increased slightly. We conclude that hypoxia, hypercapnia, and hypoxic hypercapnia have little direct influence on vascular capacitance, but with reflexes intact, there is a significant reflex increase in mean circulatory filling pressure.
Rothe
C F
CF
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis 46223.
Flanagan
A D
AD
Maass-Moreno
R
R
D000818:Animals; D001784:Blood Gas Analysis; D001810:Blood Volume; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology; D012018:Reflex / Q000502:physiology*; D014655:Vascular Resistance
D006584:Hexamethonium Compounds; D009638:Norepinephrine