[Prevention of stress-induced changes in coronary autoregulation of vasodilative reserve of the coronary vessels and contractile function of the isolated heart with small doses of thyroid hormones].
The possibility to restrict stress disturbances of coronary blood flow and contractile myocardium function with small doses of thyroid hormones has been studied on 46 hearts of female rats isolated by the Langendorff method. It is found that small doses of thyroidin increase the force of systoles and adequately increase relative coronary blood flow, coronary reserve vasodilatation, significantly prevent stress disturbances of coronary autoregulation, the force and rate of the myocardium contraction and relaxation, that restricts disproportion between contractive function and coronary blood flow.
Bozhko
A P
AP
Solodkov
A P
AP
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003327:Coronary Disease / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006706:Homeostasis; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012149:Restraint, Physical; D013268:Stimulation, Chemical; D013315:Stress, Psychological / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000008:administration & dosage* / Q000494:pharmacology
D013963:Thyroid Hormones; C004227:thyroidin
Preduprezhdenie stressovykh izmeneniĭ koronarnoĭ autoreguliatsii rasshiritel'nogo rezerva koronarnykh sosudov i sokratitel'noĭ funktsii izolirovannogo serdtsa malymi dozami tireoidnykh gormonov.