Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.
In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus. Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.
Aricó
M
M
Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Italy.
Nespoli
L
L
Porta
F
F
Caselli
D
D
Raiteri
E
E
Burgio
G R
GR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008508:Medication Errors; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
D004317:Doxorubicin