title: Strain-dependent differences in hippocampal glucocorticoid binding capacity and active avoidance in the mouse.
abstract: Maximal individual [3H]corticosterone binding capacity in the hippocampus was lower in C57BL/6 mice than in BALB/c mice, and positively correlated with active avoidance learning in the two strains. Moreover, a parallel difference in the activity of hypothalamo-pituitary adrenocortical axis (HPAA) was found, consisting in a level of plasma corticosterone in C57BL/6 higher than in BALB/c mice. These results confirm the genetically determined differences in behavior of C57BL/6 and BALB/c mice, and demonstrate their association with differences in hippocampal corticosterone binding capacity, pointing to a functional relationship between the behavioral and neuroendocrine parameters.
authors.affiliation: Instituto di Farmacologia 2a, Medical Faculty, University of Rome, La Sapienza, Italy.
authors.forename: F R
authors.initials: FR
authors.lastname: Patacchioli
authors.forename: S
authors.initials: S
authors.lastname: Puglisi-Allegra
authors.forename: S
authors.initials: S
authors.lastname: Maccari
authors.forename: P
authors.initials: P
authors.lastname: Casolini
authors.forename: L
authors.initials: L
authors.lastname: Angelucci
authors.forename: S
authors.initials: S
authors.lastname: Cabib
authors.forename: A
authors.initials: A
authors.lastname: Oliverio
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003345:Corticosterone / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D011987:Receptors, Steroid; D013045:Species Specificity
chemical_list: D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D003345:Corticosterone