[The formation of carcinogenic nitrosamines from a small amount of precursors in human gastric juice].
It has been shown in vitro with human acidic gastric juice the nitrosomorpholine (NMOR) formation from small doses of precursors (sodium nitrite and morpholine) with a significant difference relative to the control. The presented data suggest the possibility of the nitrosation reaction in the human gastric juice under hypo- and anacidic conditions. The data obtained are one more experimental confirmation of the epidemiological evidence of the potential role of nitrates (nitrites) in the etiology of stomach and esophageal cancers.
Korchenko
V A
VA
Il'nitskiĭ
A P
AP
Ermilov
V B
VB
Mistakopulo
G M
GM
Nechipaĭ
A M
AM
D000588:Amines / Q000378:metabolism; D000632:Aminopyrine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009025:Morpholines / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*
D000588:Amines; D009025:Morpholines; D009573:Nitrites; D009602:Nitrosamines; D000632:Aminopyrine; C037574:morpholine
Obrazovanie kantserogennykh nitrozaminov iz malogo kolichestva predshestvennikov v zheludochnom soke cheloveka.