title: Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk.
abstract: Vitamin B-6 status, assessed by plasma pyridoxal phosphate (PLP) concentrations, and vitamin B-6 concentrations in breast milk were examined in 47 lactating mothers supplemented with different amounts of pyridoxine.HCl (PN.HCl) during pregnancy and the first 6 mo of lactation. PLP concentrations in cord blood and maternal plasma at 2 d postpartum and vitamin B-6 concentration in colostrum were positively correlated with the amount of PN.HCl supplementation prenatally (r = 0.71, p less than 0.001; r = 0.74, p less than 0.001; and r = 0.78, p less than 0.001, respectively). Correlations between the amounts of PN.HCl supplementation postnatally and plasma PLP concentrations increased with the length of supplementation. Plasma PLP concentrations were also correlated with vitamin B-6 concentrations of milk samples, which were obtained on the same day as plasma. PN.HCl supplements between 2.5 and 4.0 mg/d (2.1-3.4 mg PN equivalents) ensured vitamin B-6 adequacy of the mother and maintained relatively saturated concentrations of vitamin B-6 in breast milk.
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chang
authors.forename: A
authors.initials: A
authors.lastname: Kirksey
mesh_terms: D000328:Adult; D003126:Colostrum / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005527:Food, Fortified / Q000032:analysis; D006801:Humans; D007774:Lactation; D008895:Milk, Human / Q000032:analysis*; D009752:Nutritional Status; D011247:Pregnancy; D011736:Pyridoxine / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood
chemical_list: D011736:Pyridoxine