Influence of Pasteurella haemolytica A1 crude leukotoxin on bovine neutrophil chemiluminescence.
Pasteurella haemolytica A1 crude leukotoxin (25%, vol/vol) rapidly diminished the bovine neutrophil chemiluminescence response to opsonized zymosan. This inhibition was neither prevented nor reversed by 75 mM sucrose. Dilute leukotoxin did not directly stimulate neutrophil chemiluminescence nor did it alter the chemiluminescence response of the neutrophils to opsonized zymosan.
Czuprynski
C J
CJ
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
Noel
E J
EJ
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D002417:Cattle; D003603:Cytotoxins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005098:Exotoxins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009504:Neutrophils / Q000382:microbiology* / Q000502:physiology; D010325:Pasteurella / Q000472:pathogenicity*; D015054:Zymosan / Q000494:pharmacology
D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; C018579:leukotoxin; D015054:Zymosan