Influence of host age and tumor load on the growth and catecholamine content of C-1300 murine neuroblastoma in situ.
The influence of host age and tumor load on survival time, tumor growth parameters and biochemical differentiation, as characterized by tumor catecholamine content, were investigated. A/J mice were implanted with tumor loads of 10(4), 10(5) and 10(6) disaggregated C-1300 murine neuroblastoma (MNB) cells at 1, 7, 14, 21 and 56 days of age. Studies performed in mice between 7 and 56 days of age demonstrated that MNB tumorigenicity, tumor growth rate, host survival and catecholamine content were independent of host age and tumor load whereas, tumor onset time was influenced by both factors. In contrast to older animals, tumor onset time and catecholamine content were decreased and tumor growth rate increased in 1-day-old mice. This difference may be due to the presence of endogenous growth factor(s) that modulate cell proliferation in the immediate post-natal period.
Fink
D W
DW
Department of Pediatrics, University of Minnesota, Minneapolis 55455.
Horn
P T
PT
Mirkin
B L
BL
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D002395:Catecholamines / Q000032:analysis*; D051379:Mice; D009447:Neuroblastoma / Q000032:analysis / Q000473:pathology*
D002395:Catecholamines