Duodenogastric reflux in children: measurement of phospholipids and trypsin in gastric content.
The duodenogastric reflux (DGR) is a suspected cause in some esogastric pathologies in adults: esophagitis, peptic gastric ulcers, stress ulcers, ulcers secondary to drugs, gastric cancer, and gastritis. The toxic substances of the reflux are essentially bile acids, lysolecithin, and trypsin. A number of diagnostic methods have been proposed in the adult. This study suggests a diagnosis technique for DGR in the child. Fasting gastric juice was collected by gastric intubation during 1 h and three substances were measured: phospholipids as markers of biliary reflux, trypsin as a marker of pancreatic reflux, and sialic acid as a marker of the degradation of gastric mucus. The sialic acid enabled us to evaluate some of the toxicity of DGR on the stomach. The study of 49 child subjects permitted us to show the existence, in the normal child, of biliopancreatic markers in the stomach under fasting conditions through a physiological DGR; to define the norms in the child, varying according to three age groups: 0-2 months, 2-12 months, and 1-4 years (the maximum values for an age above 4 years seemed to correspond to those in the adult); and to suggest the existence of a pathological DGR in children with antral gastritis or ulcers.
Mouterde
O
O
Hôpital Robert Debré, Paris, France.
Foucaud
P
P
Vatier
J
J
Dupont
C
C
Navarro
J
J
D000367:Age Factors; D015415:Biomarkers / Q000032:analysis; D002675:Child, Preschool; D004383:Duodenogastric Reflux / Q000378:metabolism*; D005750:Gastric Juice / Q000032:analysis*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019158:N-Acetylneuraminic Acid; D010743:Phospholipids / Q000032:analysis*; D012636:Secretory Rate; D012794:Sialic Acids / Q000032:analysis / Q000502:physiology; D013223:Statistics as Topic; D014357:Trypsin / Q000032:analysis* / Q000502:physiology
D015415:Biomarkers; D010743:Phospholipids; D012794:Sialic Acids; D014357:Trypsin; D019158:N-Acetylneuraminic Acid