title: Chlorpromazine disposition in relation to age in children.
abstract: The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children. The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = -0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.
authors.affiliation: Department of Pharmacology, University of Padua, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Furlanut
authors.forename: P
authors.initials: P
authors.lastname: Benetello
authors.forename: M
authors.initials: M
authors.lastname: Baraldo
authors.forename: G
authors.initials: G
authors.lastname: Zara
authors.forename: G
authors.initials: G
authors.lastname: Montanari
authors.forename: F
authors.initials: F
authors.lastname: Donzelli
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male
chemical_list: D002746:Chlorpromazine