title: Right ventricular diastolic function in systemic hypertension.
abstract: Right (RV) and left ventricular (LV) diastolic function was evaluated in 50 patients with mild, uncomplicated essential hypertension using pulsed-wave Doppler echocardiography. Patients with pulmonary, valvular or coronary artery disease were excluded and antihypertensive drugs were discontinued for the 2 weeks preceding the study. Ten normotensive patients without heart disease acted as control subjects. In the hypertensive patients, RV peak velocity of atrial filling was higher (42 +/- 10 vs 31 +/- 7 cm/s, p less than 0.01) and deceleration half-time was prolonged (96 +/- 20 vs 83 +/- 10 ms, difference not significant); ratio of early/atrial filling velocity (1.1 +/- 0.3 vs 1.7 +/- 0.4, p less than 0.001) and peak filling rate corrected to stroke volume (3.6 +/- 0.7 vs 5.3 +/- 0.9 SV/s, p less than 0.001) were lower. LV filling parameters showed similar changes. RV filling parameters did not correlate with age, LV mass or septal thickness but correlated weakly with LV radius/thickness ratio. There was good correlation between RV and the following corresponding LV filling parameters: peak filling rate, r = 0.68, p less than 0.001; ratio of early/atrial filling, r = 0.88, p less than 0.0001; and deceleration half-time, r = 0.62, p less than 0.001. Data indicate that RV diastolic function is abnormal in essential hypertension and these abnormalities are closely related to those of LV diastolic function.
authors.affiliation: Department of Medicine, University of Miami School of Medicine, Florida.
authors.forename: S
authors.initials: S
authors.lastname: Chakko
authors.forename: E
authors.initials: E
authors.lastname: de Marchena
authors.forename: K M
authors.initials: KM
authors.lastname: Kessler
authors.forename: B J
authors.initials: BJ
authors.lastname: Materson
authors.forename: R J
authors.initials: RJ
authors.lastname: Myerburg
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*