Influence of immobilization stress on the phospholipid composition of alveolar surfactant and lungs in rats.
The influence of immobilization stress on the lipid composition of alveolar surfactant and lungs in rats immobilized for 12 and 24 hours, the effects of phospholipase A2, and lipid transfer activity in alveolar surfactant were investigated. The results indicate that alveolar surfactant phospholipids underwent more significant alterations compared to lung phospholipids. Furthermore, phospholipase A2 and lipid transfer activity were reduced in alveolar surfactant of immobilized rats. The reported data suggest that the lower lipid transfer activity might be responsible for the reduced phospholipids in the surfactant system.
Yanev
E
E
Department of Pathophysiology, Bulgarian Medical Academy.
Momchilova-Pankova
A
A
Markovska
T
T
Koumanov
K
K
Kenarov
P
P
McGuigan
F J
FJ
Nicolov
N
N
D000818:Animals; D001143:Arousal / Q000502:physiology*; D007103:Immobilization / Q000502:physiology; D008297:Male; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000201:enzymology; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000150:complications*
D010743:Phospholipids; D011663:Pulmonary Surfactants; D010741:Phospholipases A; D054467:Phospholipases A2