title: Experimental Haemophilus somnus infection in pregnant cattle.
abstract: Of five pregnant cows inoculated intravenously with 5 X 10(8) viable 'Haemophilus somnus', one aborted within 5 days and excreted 'H. somnus' from the vagina for a further 7 weeks. A second cow proceeded to full term parturition but both it and its apparently healthy calf persistently excreted 'H. somnus'. The other animals underwent normal full term calvings and 'H. somnus' was not isolated from them or their calves. Lesions attributable to 'H. somnus' were detected only in the aborted fetus which showed an acute generalized inflammatory cell response consistent with a systemic Gram-negative bacterial infection. 'H. somnus' was isolated from all fetal tissues, including the placenta. The fetus and placenta also showed evidence of damage prior to inoculation. The placental damage may have predisposed the fetus and placenta to infection with 'H. somnus'. The placental epithelial cells contained intracytoplasmic organisms with the morphological and antigenic properties of 'H. somnus'.
authors.affiliation: Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, New Haw, Weybridge.
authors.forename: F A
authors.initials: FA
authors.lastname: Stuart
authors.forename: M J
authors.initials: MJ
authors.lastname: Corbel
authors.forename: C
authors.initials: C
authors.lastname: Richardson
authors.forename: R A
authors.initials: RA
authors.lastname: Brewer
authors.forename: R
authors.initials: R
authors.lastname: Bradley
authors.forename: A W
authors.initials: AW
authors.lastname: Bridges
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D005260:Female; D005313:Fetal Death / Q000473:pathology / Q000662:veterinary*; D006192:Haemophilus Infections / Q000473:pathology / Q000662:veterinary*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000662:veterinary*