Acquired Robertsonian translocations in hematologic malignancy. A rare mechanism of clonal evolution.
We identified three patients with an acquired Robertsonian translocation among 1,200 patients with hematopoietic malignancy. In each case the translocation served to produce partial chromosomal trisomy or tetrasomy within the malignant clone. Acquired Robertsonian translocation represents another, although rare, mechanism of clonal evolution in malignant cells.
Horsman
D E
DE
Department of Pathology, Cancer Control Agency of British Columbia, Vancouver, Canada.
Kalousek
D K
DK
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications / Q000235:genetics; D013922:Thrombocytosis / Q000150:complications / Q000235:genetics; D014178:Translocation, Genetic; D014314:Trisomy