title: The cause of coagulopathy after peritoneovenous shunt for malignant ascites.
abstract: Thirty-five patients with malignant ascites who received a peritoneovenous shunt were studied to determine the type and duration of postoperative coagulopathy. Coagulation factors were measured before and on the first and third day after the placement of a Denver peritoneovenous shunt; 1 to 10 L of ascites was removed at operation. Levels of platelets, antithrombin III, plasminogen, antiplasmin, fibrinogen, and factors V and VIII decreased by the first postoperative day but did not change further through the third day. The levels of fibrinolytic split products increased on day 1 but were lower by day 3. The platelet count reduction by the third day correlated with the hematocrit change (-0.031). The prothrombin and activated partial thromboplastin times remained normal postoperatively. The patterns of change were similar for patients with positive (n = 18) and negative (n = 17) ascites cytologic findings, with elevated (n = 24) and normal (n = 11) preoperative fibrinolytic split product levels, and elevated bilirubin value (greater than 25 mumol/L; n = 9), and no jaundice (n = 26). Bleeding did not occur. The data indicated that plasminogen-rather than thromboplastin-activated fibrinolysis occurred and that platelet reduction was largely dilutional. The reactions were not progressive when ascites was removed operatively.
authors.affiliation: Surgical Service, Zablocki Veterans Administration Medical Center, Milwaukee, Wis.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gleysteen
authors.forename: C V
authors.initials: CV
authors.lastname: Hussey
authors.forename: M G
authors.initials: MG
authors.lastname: Heckman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001201:Ascites / Q000209:etiology / Q000601:surgery*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010314:Partial Thromboplastin Time; D010536:Peritoneovenous Shunt / Q000009:adverse effects*; D010976:Platelet Count; D011517:Prothrombin Time
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen