title: [Value of the elastase-alpha 1-proteinase inhibitor complex in pediatric oncologic patients with fever].
abstract: The elastase-alpha1-proteinase inhibitor complex (E-alpha 1-PI) is a well known, sensitive indicator of infection. The significance of this parameter was investigated in 12 febrile paediatric-oncological patients. With neutrophil counts greater than 500/microliters infections caused a definitive increase in E-alpha 1-PI serving as an additional diagnostic parameter. E-alpha 1-PI provided no additional information in situations of sepsis with leukopenia and simultaneous agranulocytosis. In patients with metastatic tumours, the assay of E-alpha 1-PI may differentiate between infection-related and tumour-related serological disturbances.
authors.affiliation: Kinderklinik, der Johannes-Gutenberg-Universität Mainz.
authors.forename: A
authors.initials: A
authors.lastname: Huber
authors.forename: G
authors.initials: G
authors.lastname: Hafner
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000201:enzymology / Q000209:etiology*; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000201:enzymology; D007958:Leukocyte Count; D009369:Neoplasms / Q000150:complications* / Q000201:enzymology; D009504:Neutrophils / Q000201:enzymology; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000201:enzymology; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D000515:alpha 1-Antitrypsin
vernacular_title: Wertigkeit des Elastase-alpha1-Proteinaseinhibitor-Komplexes bei pädiatrisch-onkologischen Patienten mit Fieber.