title: Effect of exogenous porcine somatotropin administration on nitrogen and energy metabolism in three genotypes of pigs.
abstract: Effects of exogenous administration of porcine recombinant somatotropin (rpST) on protein gain and metabolic rate were measured in three genotypes (castrated males) of pigs (Pietrain, Duroc and a crossbreed between Dutch Yorkshire and Dutch Landrace). Six pigs of each genotype were assigned at approximately 60 kg to receive pST doses of either 0 (C) or 14 mg (T) administered i.m. twice weekly over 10 wk. Pigs were housed in individual metabolism cages at a room temperature of 20 to 22 degrees C and received feed at 2.6 times maintenance. Protein gain (N x 6.25) was measured over the final 6 wk of the 10-wk test period. For 2 wk in the test period (wk 2 and wk 5), six pigs of each treatment x genotype group were placed in a large respiration chamber and energy balances (in protein and fat) and metabolic rate were measured. Rate of weight gain measured over the final 6 wk of the experimental period increased by 105 g/d (13%) with rpST administration (P less than .01). Daily protein gain over 6 wk was increased by 48 g/animal with application of rpST (P less than .001). There was a genotype x treatment interaction (P less than .01) for protein gain. Daily protein gain in Durocs with pST treatment was increased (39%) more than in crossbreds (31%). Daily fat gain was decreased by 42 g/animal (P less than .001) by T. Daily heat production with rpST was increased by 12 kcal/kg.75, which is comparable to a 12% increase in the maintenance energy requirement.
authors.affiliation: Dept. of Anim. Nutr., Agricultural University, Wageningen, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Verstegen
authors.forename: W
authors.initials: W
authors.lastname: van der Hel
authors.forename: A M
authors.initials: AM
authors.lastname: Henken
authors.forename: J
authors.initials: J
authors.lastname: Huisman
authors.forename: E
authors.initials: E
authors.lastname: Kanis
authors.forename: P
authors.initials: P
authors.lastname: van der Wal
authors.forename: E J
authors.initials: EJ
authors.lastname: van Weerden
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D004063:Digestion; D004734:Energy Metabolism / Q000187:drug effects*; D005838:Genotype; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine / Q000235:genetics / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone; D009584:Nitrogen