[The effect of CdCl2 and ZnCl2 on Dunn osteosarcoma].
Three murine sarcoma cells (Dunn osteosarcoma, Gunma clone-4, Sarcoma 1509a) were cultured for four days at various concentrations of CdCl2 or ZnCl2 and assayed for their viability. Dunn osteosarcoma was more sensitive to CdCl2 and less sensitive to ZnCl2 than the others. CdCl2 and ZnCl2 were weekly administered to C3H/He mice intraperitoneally from three days after the inoculation of Dunn osteosarcoma. The size of the tumors was measured twice a week for five weeks. CdCl2 suppressed the growth of the tumor, whereas ZnCl2 did not. These results suggest that CdCl2 has antitumor activity, especially against osteosarcoma.
Noda
K
K
Department of Orthopaedic Surgery, Gunma University School of Medicine, Japan.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002104:Cadmium / Q000494:pharmacology* / Q000627:therapeutic use; D019256:Cadmium Chloride; D002470:Cell Survival / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology* / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D015032:Zinc / Q000494:pharmacology* / Q000627:therapeutic use; D017967:Zinc Compounds
D000970:Antineoplastic Agents; D002712:Chlorides; D017967:Zinc Compounds; D002104:Cadmium; C016837:zinc chloride; D015032:Zinc; D019256:Cadmium Chloride