Radioimmunodetection of uterine leiomyosarcoma with 111In-labeled monoclonal antimyosin antibody Fab fragments.
Radioimmunodetection of uterine leiomyosarcoma in a 64-year-old woman with a palpable local recurrence is described. Pathological abdominal, pelvic, and thoracic accumulation of monoclonal 111In-labeled antimyosin was observed. Afterward, these lesions were examined by whole-body X-ray computed tomography. With a double-tracer technique (pulmonary and hepatic/splenic subtractions) the lesions were delineated better and SPECT (radioisotope tomography) was used for more accurate localization of the abdominal and pelvic lesions. These findings indicate that antimyosin scintigraphy might be useful in staging and follow-up of uterine leiomyosarcoma.
Kairemo
K J
KJ
Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
Lehtovirta
P
P
D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D009218:Myosins / Q000276:immunology; D011877:Radionuclide Imaging; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D009218:Myosins