Impairment of theophylline clearance by a hypocaloric low-protein diet in chronic obstructive pulmonary disease.
The effect of a hypocaloric, low protein diet on theophylline kinetics was studied in a 70-year-old man with chronic obstructive pulmonary disease who lost 6.2 kg of weight. Total systemic clearance, unbound clearance, and intrinsic hepatic clearance fell dramatically. Theophylline elimination half-life rose from 8.4 to 17.1 h. Therefore, a diet deficient in both calories and protein can significantly impair theophylline clearance and prolong theophylline elimination half-life.
Juan
D
D
Clinical Research Center, Northwestern Memorial Hospital, Chicago, Illinois.
Shin
S G
SG
Fisher
M
M
Hughes
R L
RL
D000368:Aged; D004038:Diet, Reducing / Q000009:adverse effects*; D004044:Dietary Proteins / Q000008:administration & dosage*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D013806:Theophylline / Q000493:pharmacokinetics*
D004044:Dietary Proteins; D013806:Theophylline