title: [Delayed Sumithion intoxication].
abstract: A case of delayed Sumithion (fenitrothion) intoxication is reported. A 52-year-old man ingested 10 ml of Sumithion in order to commit suicide with alcohol and triazoram. Several hours later, he was admitted to our hospital because of clouding consciousness. On admission, he was somnolent, but had no other symptoms, especially suggested organophosphorus intoxication. After 40 hours, fasciculation and salivation, which are early symptoms of organophosphorus intoxication, gradually appeared. The concentration of Sumithion in the blood was measured during the course and its metabolism was represented phalmacokineticaly by a 2-compartment model. The retarded metabolism of the Sumithion was suggested by this model. It is considered that the retarded metabolism of Sumithion caused the delayed intoxication.
authors.affiliation: Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kohriyama
authors.forename: I
authors.initials: I
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Imazu
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: H
authors.initials: H
authors.lastname: Araki
mesh_terms: D001711:Biotransformation; D002802:Cholinesterases / Q000097:blood; D005278:Fenitrothion / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002802:Cholinesterases; D005278:Fenitrothion