title: Glycose aminoglycane excretion and concentration in the urine of patients with frequently recurrent calcium-oxalate lithiasis prior to and following Diclofenac-Na therapy.
abstract: Excretion and concentration of glycose aminoglycans were measured in 19 patients with frequent relapses of calcium-oxalate lithiasis, prior to and two weeks after onset of Diclofenac-Na therapy. In most patients, markedly enhanced glycose aminoglycan concentration and excretion could be demonstrated. Elevation of the high-molecular inhibitor potential in the urine results in reduced risk of calcium-oxalate lithogenesis, which may explain the therapeutic success of nonsteroidal anti-inflammatory drugs in the treatment of therapy resistant calcium-oxalate lithiasis.
authors.affiliation: Clinic and Outpatient Department of Urology, Friedrich Schiller University, Jena, GDR.
authors.forename: P
authors.initials: P
authors.lastname: Brundig
authors.forename: R H
authors.initials: RH
authors.lastname: Börner
authors.forename: R
authors.initials: R
authors.lastname: Haerting
authors.forename: V
authors.initials: V
authors.lastname: Janitzky
authors.forename: A
authors.initials: A
authors.lastname: Schlichter
mesh_terms: D002129:Calcium Oxalate / Q000652:urine*; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014545:Urinary Calculi / Q000188:drug therapy* / Q000652:urine
chemical_list: D006025:Glycosaminoglycans; D004008:Diclofenac; D002129:Calcium Oxalate