title: Repeated oral administration of activated charcoal for treating aspirin overdose in young children.
abstract: The data from our two patients indicates that gastrointestinal dialysis with repeated oral doses of activated charcoal may significantly enhance the elimination of overdoses of salicylate in young children. Limited experience precludes precise recommendations, but current evidence suggests that gastrointestinal dialysis should be evaluated further for treating pediatric salicylate intoxication.
authors.affiliation: New Mexico Poison and Drug Information Center, Division of Pulmonary/Intensive Care, Albuquerque.
authors.forename: J E
authors.initials: JE
authors.lastname: Vertrees
authors.forename: B C
authors.initials: BC
authors.lastname: McWilliams
authors.forename: H W
authors.initials: HW
authors.lastname: Kelly
mesh_terms: D000284:Administration, Oral; D001241:Aspirin / Q000493:pharmacokinetics / Q000506:poisoning*; D002606:Charcoal / Q000008:administration & dosage* / Q000627:therapeutic use; D003956:Dialysis / Q000379:methods; D006207:Half-Life; D006801:Humans; D007223:Infant; D008278:Magnesium Sulfate / Q000008:administration & dosage; D008297:Male; D012459:Salicylates / Q000493:pharmacokinetics / Q000506:poisoning; D020156:Salicylic Acid
chemical_list: D012459:Salicylates; D002606:Charcoal; D008278:Magnesium Sulfate; D020156:Salicylic Acid; D001241:Aspirin