title: Growth hormone increases rate of pubertal maturation.
abstract: We have performed a retrospective analysis of the pubertal parameters of 134 children with isolated GH insufficiency on GH treatment and compared them to the standards of Tanner and to a recent longitudinal study of growth and development in the United Kingdom. The age at onset of puberty (13.0 years in boys, 12.1 years in girls) was found to be significantly delayed (Mann-Whitney p less than 0.001), but duration of puberty (1.5 years in both sexes) was shortened (Kolgomarov-Smirnov p less than 0.01). Skeletal maturity at the onset of puberty was not advanced excluding this as a contributory factor. There was no association between dose of GH administered and the pubertal parameters. The results suggest that GH accelerates the pubertal process.
authors.affiliation: Kabi International Growth Research Centre, Endocrine Unit, Middlesex Hospital, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Darendeliler
authors.forename: P C
authors.initials: PC
authors.lastname: Hindmarsh
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
authors.forename: L
authors.initials: L
authors.lastname: Cox
authors.forename: C G
authors.initials: CG
authors.lastname: Brook
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011627:Puberty / Q000187:drug effects*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D013006:Growth Hormone