Permanent conversion of NIH3T3 cells transformed by activated c-Ha-ras, c-Ki-ras, N-ras, or c-raf, and of human pancreatic adenocarcinoma containing activated c-Ki-ras to apparently normal cells by treatment with the antibiotic azatyrosine.
Shindo-Okada
N
N
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
Makabe
O
O
Nagahara
H
H
Nishimura
S
S
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; C011870:beta-(5-hydroxy-2-pyridyl)alanine; D000409:Alanine