title: Childhood obsessive-compulsive disorder: a prospective follow-up study.
abstract: Twenty-five of 27 patients (93%) who had participated in a study of severe primary obsessive-compulsive disorder with onset in childhood or adolescence, were seen 2-7 yrs after initial examination (mean, 4.4 yrs). They were compared to a group of normal controls matched for age, sex and IQ and followed up for the same period. Continued psychopathology was striking for the patients, with only seven (28%), three males and four females, receiving no psychiatric diagnosis at follow-up. Seventeen subjects (68%) still had obsessive-compulsive disorder, 12 patients (48%) had another psychiatric disorder, most commonly anxiety and/or depression; neither initial response to clomipramine or any other baseline variable predicted outcome.
authors.affiliation: Hôpital International, l'Université de Paris, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Flament
authors.forename: E
authors.initials: E
authors.lastname: Koby
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
authors.forename: C J
authors.initials: CJ
authors.lastname: Berg
authors.forename: T
authors.initials: T
authors.lastname: Zahn
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: M
authors.initials: M
authors.lastname: Denckla
authors.forename: M
authors.initials: M
authors.lastname: Lenane
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000150:complications / Q000175:diagnosis; D002648:Child; D002997:Clomipramine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis; D003907:Dexamethasone; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D010555:Personality Inventory; D011379:Prognosis; D011446:Prospective Studies; D012647:Self-Assessment
chemical_list: D003907:Dexamethasone; D002997:Clomipramine