title: Post mortem kinetics of secobarbital.
abstract: Post-mortem changes in barbiturate concentrations were evidenced using a rat-secobarbital model. The method used for the extraction and HPLC assay of barbiturates is suitable for all biologic fluids and post-mortem tissues. Kinetic data obtained is of excellent quality. Various modelization constants were defined. This experimental work emphasizes the difficulty of post-mortem toxicology, as concentrations found at the time of autopsy may be different from concentrations at the time of death, in blood as well as in tissues.
authors.affiliation: Laboratoire de Médecine Légale, Faculté de Medecine, Nice, France.
authors.forename: G
authors.initials: G
authors.lastname: Quatrehomme
authors.forename: F
authors.initials: F
authors.lastname: Bourret
authors.forename: M
authors.initials: M
authors.lastname: Zhioua
authors.forename: P
authors.initials: P
authors.lastname: Lapalus
authors.forename: A
authors.initials: A
authors.lastname: Ollier
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D011180:Postmortem Changes; D051381:Rats; D011919:Rats, Inbred Strains; D012631:Secobarbital / Q000493:pharmacokinetics*
chemical_list: D012631:Secobarbital