[Recombinant tumor necrosis factor promotes the formation of hematogenic metastases to the lungs of C57Bl/6 mice].
The intravenous injection of the recombinant tumour necrosis factor (rTNF) to the C57BL/6 mice at a dose of 10(4) U 1.4 and 24 hours before or 4 hours after the intravenous inoculation of the LL (Lewis carcinoma) or MM-4 (B-16 melanoma) cells was found to be accompanied by a significant increase in the number of hematogenic metastases in the lungs of animals. The above rTNF effect could be considerably inhibited by the single heparin injection.
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D000818:Animals; D005260:Female; D006493:Heparin / Q000494:pharmacology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating / Q000187:drug effects*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D006493:Heparin
Rekombinantnyĭ faktor nekroza opukholeĭ sposobstvuet formirovaniiu gematogennykh metastazov v legkikh mysheĭ C57Bl/6.