Gastrointestinal type 1 hypersensitivity to azathioprine.
We report the case of a 49-year-old patient with progressive sensomotor polyneuropathy who developed nausea, vomiting, and diarrhea after 2 1/2 months of azathioprine therapy. Administration of the drug was interrupted. These symptoms recurred immediately after rechallenge with azathioprine. A duodenal biopsy demonstrated a massive local eosinophilia without peripheral blood eosinophilia. Cutane testing with azathioprine showed a positive type 1 reaction. We diagnosed a hypersensitive reaction type 1 in the duodenal mucosa on the basis of the histological features, the history, and the cutane reaction.
Riedel
R R
RR
Universitäts Nervenklinik, Bonn.
Schmitt
A
A
de Jonge
J P
JP
Hartmann
A
A
D001379:Azathioprine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000473:pathology*; D004487:Edema / Q000473:pathology; D004802:Eosinophilia / Q000473:pathology; D005759:Gastroenteritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D011115:Polyneuropathies / Q000188:drug therapy*; D012677:Sensation / Q000187:drug effects*
D001379:Azathioprine