Selective eradication of leukemic (L-CFU) versus normal (CFU-GM) myeloid progenitors in suspension culture utilizing a prolonged exposure to 1-B-D arabinofuranosylcytosine (Ara-C) and deoxycytidine (dCyd).
Grant
S
S
Division of Hematology/Oncology, Medical College of Virginia, Richmond 23298.
Howe
C
C
Kuczynski
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002469:Cell Separation; D002478:Cells, Cultured; D003561:Cytarabine / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008264:Macrophages / Q000187:drug effects; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D013234:Stem Cells / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D003561:Cytarabine; D003841:Deoxycytidine