title: Cross-reaction in allergic contact dermatitis from alpha-methylene-gamma-butyrolactones: importance of the cis or trans ring junction.
abstract: Cross-reaction in allergic contact dermatitis (ACD) is a highly stereoselective process. The importance of the cis or trans ring junction in alpha-methylene-gamma-butyrolactones in cross-reactivity was investigated by reacting Helenin (mostly a mixture of natural allergenic sesquiterpene lactones alantolactone 1 and isoalantolactone 2, which present a cis ring junction) in guinea pigs sensitized to model allergenic alpha-methylene-gamma-butyrolactones: cis-bicyclic lactone 3 and trans-bicyclic lactone 4.
authors.affiliation: Laboratoire de Dermatochimie, Université Louis Pasteur, Clinique Dermatologique CHU de Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Schaeffer
authors.forename: P
authors.initials: P
authors.lastname: Talaga
authors.forename: J L
authors.initials: JL
authors.lastname: Stampf
authors.forename: C
authors.initials: C
authors.lastname: Benezra
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003429:Cross Reactions / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D007783:Lactones / Q000276:immunology*
chemical_list: D007783:Lactones