[Treatment of acromegaly. Results in 56 patients].
The results of the treatment of acromegaly in 56 patients have been reviewed. Transsphenoidal pituitary adenomectomy (TPA) represented the most effective therapy, as it resulted in a cure rate of 64.7%, with 8.8% of complications and 14.7% of endocrine insufficiencies secondary to surgery. When radiotherapy was administered after surgery (when the latter had not been curative), the overall rate of cure increased to 73.5%. By contrast, the patients treated only with radiotherapy had a markedly lower cure rate (44.4%), with a higher rate of endocrine insufficiency (55%). The occurrence of extrasellar extension shown in preoperative pituitary computed tomography did not correlate with a worse postoperative cure rate; by contrast, the invasive character of the adenoma represented a reduction in the postoperative cure rate. It was concluded that TPA is the treatment of choice in acromegaly, independently of the tumor size.
del Pozo
C
C
Servicio de Endocrinología y Nutrición, Hospital de la Santa Creu i Sant Pau, Barcelona.
Webb
S M
SM
Oliver
B
B
Tresserras
P
P
de Leiva
A
A
D000172:Acromegaly / Q000209:etiology / Q000628:therapy*; D000236:Adenoma / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000628:therapy*
Tratamiento de la acromegalia. Resultados en 56 pacientes.