[Relation of the occurrence of chromosome aberrations in human peripheral lymphocytes to the cell cycle].
Experimental results confirmed that the best period of cultivation of human peripheral lymphocytes for chromosomal analyses in subjects exposed to mutagens and carcinogens is 44-48 hours when the dividing lymphocytes are in the first cellular cycle. With prolongation of the cultivation period of lymphocytes the values of chromosomal aberrations decline because in subsequent cellular cycles their number declines as a result of mitotic deaths of cells which contain unstable types of aberrations.
Kalina
I
I
Katedra lekárskej biológie Lekárskej fakulty Univerzity P. J. Safárika, Kosice.
Ondrusseková
A
A
Konecná
H
H
D002453:Cell Cycle; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects / Q000648:ultrastructure*
Závislost výskytu chromozómových aberácií v l'udských periférnych lymfocytoch na bunkovom cykle.