title: 5-HT1A receptor function in depression: effect of chronic amitriptyline treatment.
abstract: Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1A-mediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulated during AMI treatment.
authors.affiliation: Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
authors.forename: K P
authors.initials: KP
authors.lastname: Lesch
authors.forename: J
authors.initials: J
authors.lastname: Disselkamp-Tietze
authors.forename: A
authors.initials: A
authors.lastname: Schmidtke
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D011743:Pyrimidines; D011985:Receptors, Serotonin; D000639:Amitriptyline; C043077:ipsapirone