title: On the evolutionary history of the circumsporozoite protein in plasmodia.
abstract: We report the complete nucleotide sequence of the circumsporozoite (CS) gene of Plasmodium brasilianum and present an analysis of its evolutionary profile. Despite the lack of a reliable time scale, the analysis of the number and distribution of fixations among seven taxa provides a first glimpse of the evolutionary history of the CS gene, and suggests that the branching events of this gene are completely unconnected with--and far precede in time--the speciation event of the parasite's vertebrate hosts.
authors.affiliation: Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10010.
authors.forename: L
authors.initials: L
authors.lastname: di Giovanni
authors.forename: A H
authors.initials: AH
authors.lastname: Cochrane
authors.forename: V
authors.initials: V
authors.lastname: Enea
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D010961:Plasmodium / Q000145:classification / Q000235:genetics*; D015800:Protozoan Proteins; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping
chemical_list: D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan; D004247:DNA