title: Parathyroid hormone is not required for normal milk composition or secretion or lactation-associated bone loss in normocalcemic rats.
abstract: To determine if parathyroid hormone (PTH) is essential for lactation in rats, the parathyroid glands were removed surgically during the first week of lactation and the rats were given a diet containing a high calcium-phosphorus ratio to maintain a normal serum calcium concentration. Lactating rats were placed on diet containing 1.2% calcium (Ca) and 0.8, 0.6, or 0.4% phosphorus (P) on day 2 postpartum (PP) and were parathyroidectomized (PTX) at 4-6 days PP. At 10 days PP serum Ca was 10.5 +/- 0.2 mg/dl (mean +/- SEM) for PTX rats and 10.4 +/- 0.3 mg/dl in sham-operated lactating rats when the diet contained 0.6% P. When the diet P was 0.8%, the litters gained little or no weight and serum Ca fell to 6.9 +/- 0.6 mg/dl by day 10 PP in PTX rats compared with 10.2 +/- 0.2 mg/dl in sham rats. PTX rats fed the diet containing 1.2% Ca and 0.6% P maintained a normal serum Ca level until at least day 18 PP, but their serum P levels fell gradually from approximately 5 mg/dl at 10 days to 3 mg/dl at 18 days PP. In spite of this hypophosphatemia, the litters of PTX and sham rats had gained the same amount of weight by age 16 days, indicating equal milk production in the two groups. Milk Ca, P, and total solids were not significantly different between PTX and sham rats on day 11 PP.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pharmacology, University of North Carolina, Chapel Hill 27599-7455.
authors.forename: S C
authors.initials: SC
authors.lastname: Garner
authors.forename: A
authors.initials: A
authors.lastname: Boass
authors.forename: S U
authors.initials: SU
authors.lastname: Toverud
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000503:physiopathology*; D002118:Calcium / Q000097:blood*; D004032:Diet; D005260:Female; D007774:Lactation / Q000502:physiology*; D008274:Magnesium / Q000097:blood; D008892:Milk / Q000378:metabolism*; D010280:Parathyroid Glands / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D051381:Rats
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium