title: Fatal complications after myelography with meglumine diatrizoate.
abstract: A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.
authors.affiliation: Department of Neurology, University of Erlangen-Nürnberg, Federal Republic of Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Hilz
authors.forename: W
authors.initials: W
authors.lastname: Huk
authors.forename: B
authors.initials: B
authors.lastname: Schellmann
authors.forename: F
authors.initials: F
authors.lastname: Sörgel
authors.forename: K F
authors.initials: KF
authors.lastname: Druschky
mesh_terms: D000368:Aged; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009192:Myelography / Q000009:adverse effects*; D009422:Nervous System Diseases / Q000139:chemically induced*; D013128:Spinal Osteophytosis / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D003974:Diatrizoate Meglumine