T-maze performance in rats following chronic neuroleptic treatment.
The effects of chronic haloperidol treatment (0.5 mg/kg/day for 21 days) on maze learning in the rat were studied. There were no differences between haloperidol- and saline-treated groups in percentage of correct responses, but the latency to respond was longer and extinction was faster in the haloperidol-treated group. We speculated that differences between both groups were due to a decrease of appetitive motivation in haloperidol-treated animals, probably caused by a decrease of dopaminergic neurotransmission.
Ferré
S
S
Laboratori de Neuropsicofarmacología Programa Sant Pau-CITRAN Fundació d'Investigació de la Santa Creu i Sant Pau Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
Prat
G
G
Guix
T
T
Gomá
M
M
Jané
F
F
Casas
M
M
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D005502:Food; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D006220:Haloperidol