[Clinical significance of ultrastructural disorganization of cell membranes in hypotrophy].
The authors describe the results of studying lipid peroxidation and ultrastructure of blood cells in children aged 1 month to 2 years, suffering from chronic distress of nutrition of the hypotrophy type. Appreciable disorders of the membranes of blood cells and their organoids were found, related to activation of free radical lipid oxidation in diseased children. The relationship was noted between destructive changes in the ultrastructure of the biological membranes and the disease gravity, duration of the effect of the high content of lipid peroxidation products on cellular and subcellular membranes. The disorganization of the membrane ultrastructure in the body of patients with hypotrophy is an important component in the disease pathogenesis and requires administration of membrane-stabilizing therapy in a complex of treatment measures.
Smiian
I S
IS
Fedortsiv
O E
OE
Smorshchok
S A
SA
D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000097:blood*; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron
Klinicheskoe znachenie ul'trastrukturnoĭ dezorganizatsii kletochnykh membran pri gipotrofii.