title: Tussive effect of a fentanyl bolus administered through a central venous catheter.
abstract: One hundred and ten male patients scheduled for coronary artery bypass grafting were allocated randomly into one of three groups. Patients in group A received fentanyl 7 micrograms/kg via a central venous catheter, those in group B were given fentanyl 7 micrograms/kg through a peripheral venous cannula, and patients in group C received sterile water via a central venous catheter. In group A, 45.9% of patients coughed after injection of fentanyl; the mean onset time from the end of fentanyl administration to the beginning of coughing was 10.6 seconds. Only one patient in group B and no patient in the control group exhibited a cough response (p less than 0.0001). We hypothesise that fentanyl can evoke the pulmonary chemoreflex.
authors.affiliation: Department of Anaesthesia, University of Heidelberg, West Germany.
authors.forename: H
authors.initials: H
authors.lastname: Böhrer
authors.forename: F
authors.initials: F
authors.lastname: Fleischer
authors.forename: P
authors.initials: P
authors.lastname: Werning
mesh_terms: D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D003371:Cough / Q000139:chemically induced*; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
chemical_list: D005283:Fentanyl