title: Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma, and erythrocytes of infant piglets.
abstract: The effect of feeding sow-milk formula (SMF) or a vegetable-oil infant formula (FF) with minimal n-6 and n-3 long-chain polyenoic fatty acids (LCPs) but high linoleic acid (18:2n-6) and a high ratio of 18:2n-6 to linolenic acid (18:3n-3) on the fatty acids of brain lipid and liver, plasma, and red cell phospholipids was studied in piglets fed from birth for 5, 10, 15, or 25 d. Compared with SMF, FF reduced the concentrations of 18:1 and n-3 LCPs, especially 22:6n-3, in all tissues and increased 22:4n-6 in brain, liver, plasma, and red cell phosphatidylethanolamine. FF also increased 22:5n-6 in brain lipid, liver, and plasma but not in red cell phospholipids. Thus, changes in tissues capable of in situ desaturation were not completely reflected in the red cell phospholipids. The increased liver and brain n-6 LCP accretion in the FF piglets may suggest competent desaturation and possible inhibition of n-3 desaturation and/or acylation by dietary n-6 fatty acids.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Hrboticky
authors.forename: M J
authors.initials: MJ
authors.lastname: MacKinnon
authors.forename: S M
authors.initials: SM
authors.lastname: Innis
mesh_terms: D000818:Animals; D001835:Body Weight; D001923:Brain Chemistry / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D004912:Erythrocytes / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007225:Infant Food; D008041:Linoleic Acids / Q000494:pharmacology*; D008099:Liver / Q000032:analysis; D008297:Male; D009929:Organ Size; D010743:Phospholipids / Q000032:analysis; D010938:Plant Oils / Q000494:pharmacology*; D013552:Swine
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D010743:Phospholipids; D010938:Plant Oils