[Role of high-dose chemotherapy followed by bone marrow autograft in the treatment of metastatic Ewing's sarcoma in children].
Thirty-two children were treated for metastatic Ewing sarcoma by high-dose chemotherapy followed by autologous bone marrow transplantation. Fourteen patients entered phase II studies of high-dose alkylating agents. The response rate observed was 61%. High-dose chemotherapy was used as consolidation in complete remission of 18 patients. Disease free survival appears to be better than that observed under conventional altered chemotherapy. However, with only 4/18 long term survivors, these results remain unsatisfactory, taking into account the recent encouraging results of semi-continuous conventional chemotherapy.
Hartmann
O
O
Département de pédiatrie, Institut Gustave-Roussy, Villejuif, France.
Oberlin
O
O
Beaujean
F
F
Brugières
L
L
Valteau
D
D
Vassal
G
G
Lemerle
J
J
D000293:Adolescent; D000477:Alkylating Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012512:Sarcoma, Ewing / Q000556:secondary* / Q000628:therapy
D000477:Alkylating Agents
Place de la chimiothérapie à hautes doses suivie d'autogreffe médullaire dans le traitement des sarcomes d'Ewing métastatiques de l'enfant.