[Diagnosis of prospective malignancy of cervix dysplasia using DNA cytometry].
134 borderline lesions of the cervix uteri (CIN I/II) were investigated by using the newly developed diagnostic method DNA-image cytometry (MIAMED-DNA, Wild-Leitz, Wetzlar). The demonstration of aneuploid cells served as a marker for prospective malignancy. 18 out of 35 cases, which proved to be CIN III in the follow-up, had a malignant DNA diagnosis. The sensitivity of the diagnostic DNA cytometry for prospective malignancy was therefore 51.4%. All 43 cases with a negative DNA diagnosis proved to be negative in the follow-up, so that the specificity of DNA cytometry was 100%. Suspicious DNA diagnosis in 26% of the cases proved to be CIN III in the follow-up. DNA cytometry seems to be a reliable method to predict the biological behaviour of borderline lesions of the cervix uteri in everyday practice.
Bollmann
R
R
Institut für Pathologie, Bonn.
D002278:Carcinoma in Situ / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D006801:Humans; D009367:Neoplasm Staging; D011003:Ploidies; D011446:Prospective Studies; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears
D004273:DNA, Neoplasm
Die Diagnose prospektiver Malignität an zervikalen Dysplasien durch DNA-Zytometrie.