title: Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study.
abstract: The distribution of cholinergic pre- and postsynaptic markers and dopaminergic presynaptic markers was analyzed in the adult human striatum, using quantitative receptor autoradiography. The distribution of the different binding sites indicates that cholinergic and dopaminergic uptake sites display a striosomal organization, with a higher binding site density in the striatal matrix. M1 muscarinic cholinergic receptor distribution parallels the distribution of cholinergic presynaptic markers. Our data show that cholinergic and dopaminergic terminals, and M1 receptors are enriched in the matrix of the adult human striatum.
authors.affiliation: Department of Psychiatry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.
authors.forename: P R
authors.initials: PR
authors.lastname: Lowenstein
authors.forename: J N
authors.initials: JN
authors.lastname: Joyce
authors.forename: J T
authors.initials: JT
authors.lastname: Coyle
authors.forename: J F
authors.initials: JF
authors.lastname: Marshall
mesh_terms: D000368:Aged; D001345:Autoradiography; D002799:Cholinergic Fibers / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000378:metabolism; D006801:Humans; D008297:Male; D008454:Mazindol / Q000378:metabolism; D010890:Pirenzepine / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*
chemical_list: D011976:Receptors, Muscarinic; D006426:Hemicholinium 3; D010890:Pirenzepine; D008454:Mazindol; D004298:Dopamine