title: Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation.
abstract: Weanling mice fed chow or chow plus water supplemented with 3.5 mg of nucleotides per 100 ml of water for 6 weeks exhibited increased natural killer cell (NK) activity and lower macrophage activation compared to mice fed chow plus nonsupplemented water. In a dose-response study, NK activity, macrophage activation and spleen weight (as a percentage of body weight) were higher in mice fed up to 0.035% w/w nucleotides, however macrophage activation was decreased by feeding over 0.35% w/w compared to those receiving basal purified diet (BPD). Nucleotides in human milk may affect the immune response in breast-fed infants.
authors.affiliation: Department of Pediatrics, University of South Florida College of Medicine, Tampa 33612.
authors.forename: J D
authors.initials: JD
authors.lastname: Carver
authors.forename: W I
authors.initials: WI
authors.lastname: Cox
authors.forename: L A
authors.initials: LA
authors.lastname: Barness
mesh_terms: D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects*; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009711:Nucleotides / Q000494:pharmacology*
chemical_list: D009711:Nucleotides