title: Quantitation of tubotympanal mucociliary clearance in otitis media with effusion.
abstract: In an attempt to analyze the tubotympanal mucociliary function in otitis media with effusion (OME), human serum albumin labeled with technetium 99m was instilled into 36 ears with effusion and 16 without. The clearance function of the tubotympanum was measured quantitatively. The viscoelasticity of the effusions was measured and was compared with the clearance rate. The clearance rate was significantly lower in ears with effusion than in those without. A significant negative correlation was observed between clearance rate and dynamic viscosity at dynamic viscosities above 2 poise. It is concluded that ears with effusion have significantly lower mucociliary clearance than those without, and that the viscosity of the effusions plays an important role in the mucociliary dysfunction in OME.
authors.affiliation: Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Majima
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakura
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004548:Elasticity; D006801:Humans; D009079:Mucociliary Clearance / Q000502:physiology*; D010034:Otitis Media with Effusion / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D014783:Viscosity
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin