Reduction of T-kininogen messenger RNA levels by dexamethasone in the adjuvant-treated rat.
When inflammation is induced in rats following injection of Freund's complete adjuvant, steady state levels of T-I and T-II kininogen mRNAs increase markedly as do plasma levels of T-I and T-II kininogens. When rats are additionally treated with dexamethasone, T-I and T-II steady state mRNA levels and plasma levels of T-kininogens are reduced. The results suggest that dexamethasone may affect the magnitude of T-kininogen gene induction caused by inflammation.
Howard
E F
EF
Department of Cell and Molecular Biology, School of Graduate Studies, Medical College of Georgia, Augusta 30912-2100.
Thompson
Y G
YG
Lapp
C A
CA
Greenbaum
L M
LM
D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D015152:Blotting, Northern; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005620:Freund's Adjuvant; D007249:Inflammation / Q000097:blood / Q000188:drug therapy*; D007704:Kininogens / Q000097:blood / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D009841:Oligonucleotides / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D007704:Kininogens; D015345:Oligonucleotide Probes; D009841:Oligonucleotides; D012333:RNA, Messenger; D003907:Dexamethasone; D005620:Freund's Adjuvant