Interactions between cell populations influence expression of the transformed phenotype in irradiated rat tracheal epithelial cells.
A combined in vivo-in vitro model has been utilized to evaluate the influence of cell-cell interactions on expression of radiation-induced transformation in irradiated rat tracheal epithelial cells. Two types of cell interactions are evaluated. One type of interaction appears to involve direct cell-cell contact as occurs within the intact tissue. The other type of communication appears to be mediated via a diffusible factor, most likely transforming growth factor type-beta. The data suggest the need to be cautious when extrapolating from transformation data obtained following irradiation of low-density rapidly proliferating cell cultures to the in vivo model.
Terzaghi-Howe
M
M
Biology Division, Oak Ridge National Laboratory, Tennessee 37831-8077.
D000818:Animals; D002450:Cell Communication; D002455:Cell Division / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000528:radiation effects; D002478:Cells, Cultured; D003470:Culture Media; D004735:Energy Transfer; D004848:Epithelium / Q000473:pathology / Q000528:radiation effects; D009502:Neutrons; D010641:Phenotype; D051381:Rats; D014132:Trachea / Q000473:pathology / Q000528:radiation effects*
D003470:Culture Media