Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children.
The term "inflammatory myofibrohistiocytic proliferation" (IMP) has been proposed to replace the conventional designations of plasma cell granuloma and inflammatory pseudotumor. Three cases of extrapulmonary IMP in children are reported, including an intracerebral lesion which has been formerly undescribed. In children, IMP may be associated with microcytic hypochromic anemia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. In this clinical setting, differentiation of a rapidly growing but benign IMP from a bona fide sarcoma is of paramount importance.
Tang
T T
TT
Department of Pathology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee 53201.
Segura
A D
AD
Oechler
H W
HW
Harb
J M
JM
Adair
S E
SE
Gregg
D C
DC
Camitta
B M
BM
Franciosi
R A
RA
D000008:Abdominal Neoplasms / Q000473:pathology; D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis*; D006099:Granuloma / Q000175:diagnosis*; D006104:Granuloma, Plasma Cell / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008297:Male; D012509:Sarcoma / Q000175:diagnosis*; D009626:Terminology as Topic; D013899:Thoracic Neoplasms / Q000473:pathology; D014057:Tomography, X-Ray Computed
D003094:Collagen