title: Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy.
abstract: We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.
authors.affiliation: Department of Neurology, Thomas Jefferson University, Philadelphia.
authors.forename: M E
authors.initials: ME
authors.lastname: Shy
authors.forename: T
authors.initials: T
authors.lastname: Heiman-Patterson
authors.forename: G J
authors.initials: GJ
authors.lastname: Parry
authors.forename: A
authors.initials: A
authors.lastname: Tahmoush
authors.forename: V A
authors.initials: VA
authors.lastname: Evans
authors.forename: P K
authors.initials: PK
authors.lastname: Schick
mesh_terms: D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate; D001323:Autoantibodies / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004187:Disaccharides / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007167:Immunotherapy; D008297:Male; D009046:Motor Neurons / Q000276:immunology*; D009468:Neuromuscular Diseases / Q000276:immunology* / Q000628:therapy
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D001323:Autoantibodies; D004187:Disaccharides; D005732:Gangliosides; D007075:Immunoglobulin M; C033851:ganglioside, GD1b; C016467:Thomsen-Friedenreich antigen; D005677:G(M1) Ganglioside