Serotonergic innervation of the rat testis.
The presence of 5-hydroxytryptamine (5-HT) was determined by h.p.l.c. in perchloric extracts of each isolated compartment of the adult rat testis. The testicular capsule, interstitial cells and interstitial fluid contained 5-HT, but 5-HT was not detected in the tubular compartment. In a group of adult rats, one testis was unilaterally denervated, and the contralateral testis used as control. The superior spermatic nerve, arising from the renal plexus, was excised and 1 week after surgery 5-HT content was measured in the capsule and interstitial fluid of both testes. Denervation caused a significant fall (34%) in 5-HT content. These results indicate that at least part of the testicular 5-HT derives from a serotonergic innervation of the gonad.
Campos
M B
MB
Laboratorio de esteroides, Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
Vitale
M L
ML
Calandra
R S
RS
Chiocchio
S R
SR
D000818:Animals; D003714:Denervation; D005110:Extracellular Space / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013737:Testis / Q000294:innervation* / Q000378:metabolism
D012701:Serotonin