[Flow cytometric DNA analysis of papillary carcinoma of the thyroid using paraffin-embedded specimens].
A flow cytometric DNA analysis of papillary thyroid carcinomas has been performed on paraffin-embedded specimens, in order to determine the clinical usefulness of this method by defining the degree of the biological malignancy. Fifty-eight patients with papillary carcinomas were followed from 2 to 8 years. They were classified according to their prognosis into three groups: non-recurrent (47 patients), recurrent (5 patients), and a deceased group (6 patients). Aneuploidy was found in 6 (10.3%) of the total 58 patients. It was more frequently detected in the recurrent (40%) and in the deceased (33.3%) groups than in the non-recurrent group (4.3%). Higher proliferating index values were observed in the deceased group than in the recurrent and non-recurrent groups. These results indicate that a DNA analysis, using routine paraffin-embedded materials, is a useful adjunct in the determination of the degree of the biological malignancy of a papillary carcinoma.
Yamashita
T
T
Dept. of Endocrine Surgery, Tokyo Women's Medical College.
Hirayama
A
A
Obara
T
T
Fujimoto
Y
Y
Kodama
T
T
Kenmotsu
M
M
Okuda
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002291:Carcinoma, Papillary / Q000032:analysis* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000032:analysis / Q000473:pathology; D010232:Paraffin; D011379:Prognosis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000032:analysis* / Q000473:pathology
D004273:DNA, Neoplasm; D010232:Paraffin