Transient hypothermia and hyperphagia induced by selenium and tellurium compounds in mice.
The effects of sublethal doses of selenite, selenate, selenocystine (Se-Cys) and selenomethionine (Se-Met) as well as of tellurite on body temperature and feeding behavior were examined in male ICR mice. Ten or 30 mumol/kg of chemicals were injected subcutaneously and body temperature was measured up to 4 h. In a separate experiment, the gastric content was weighted 4 h after injection. All chemicals except Se-Met induced both hypothermia and hyperphagia, suggesting that: (a) these two effects are related to each other; (b) among the chemicals tested, Se-Cys appears to be the most potent hypothermia inducer; (c) Se-Met is unique in that it has neither effect.
Watanabe
C
C
Department of Human Ecology, School of Health Sciences, Faculty of Medicine, University of Tokyo, Japan.
Suzuki
T
T
Ohba
T
T
Dejima
Y
Y
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003553:Cystine / Q000031:analogs & derivatives / Q000633:toxicity; D005247:Feeding Behavior / Q000187:drug effects; D006963:Hyperphagia / Q000139:chemically induced*; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds; D064586:Selenic Acid; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage* / Q000633:toxicity; D018036:Selenium Compounds; D012645:Selenomethionine / Q000633:toxicity; D013691:Tellurium / Q000633:toxicity*
D016566:Organoselenium Compounds; D018036:Selenium Compounds; C009226:selenocystine; D003553:Cystine; D012645:Selenomethionine; D020887:Selenious Acid; D012643:Selenium; D064586:Selenic Acid; D013691:Tellurium