Dam strain affects cardiovascular reactivity to acute stress in BHR.
The effect of maternal strain on reactivity to acute stress was studied in F1 reciprocals produced by crossing the spontaneously hypertensive rat (SHR) with its normotensive progenitor, the Wistar-Kyoto (WKY). This F1 generation, known as the borderline hypertensive rat (BHR), is genetically predisposed to develop hypertension in response to chronic stress or high dietary sodium. Reciprocals, considered to be genetically equivalent aside from sex-linked traits, differ in strain of dam during intrauterine and preweanling development. At 17 weeks of age, reciprocal F1 males did not differ in open-field behavior (squares crossed, rearings, and defecation measured over 3 days in 15-min sessions) or in home-cage measurements of mean arterial pressure (MAP) and heart rate (HR). However, different patterns of cardiovascular reactivity were displayed to transfer and footshock. While WKY-mothered rats reacted with graded pressor responses, SHR-mothered rats responded maximally to transfer, showed no additional increase to footshock, and maintained peak responding after footshock was terminated. Such reactivity differences may mediate the impact of environmental variables on the genetic disposition to hypertension.
Woodworth
C H
CH
Department of Psychology, University of Iowa, Iowa City 52242.
Knardahl
S
S
Sanders
B J
BJ
Kirby
R F
RF
Johnson
A K
AK
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001794:Blood Pressure; D003433:Crosses, Genetic; D004597:Electroshock; D006339:Heart Rate; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology*