Supplemental taurine in diabetic rats: effects on plasma glucose and triglycerides.
The present study has indicated that significant shifts in plasma, urinary, and tissue taurine and in non-taurine dialyzable amines occur in the STZ-induced diabetic rat, especially in the kidney. Taurine administration at relatively low dosage ameliorated only kidney taurine concentration. Anticipated alterations in plasma glucose and creatinine were observed but neither of these changes was affected by taurine administration. Similarly, urinary output of creatinine, glucose, and NAG increased significantly among diabetic rats, but none of these were detectably influenced by taurine. Increases in plasma triglycerides observed in STZ-induced diabetes appear to be attenuated by taurine administration, and although cholesterol concentrations were lower in taurine-treated rats, the differences were not statistically significant. These findings should encourage further studies of these effects in rats as a useful model for several complications of human diabetes including atherosclerosis, retinopathy, and nephropathy.
Goodman
H O
HO
Department of Pediatrics, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Shihabi
Z K
ZK
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution; D014280:Triglycerides / Q000097:blood*
D000596:Amino Acids; D001786:Blood Glucose; D014280:Triglycerides; D013654:Taurine; D002784:Cholesterol