title: Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition.
abstract: Infection with Helicobacter pylori (formerly Campylobacter pylori) was studied by measuring antibody titres to H pylori in Gambian children. Serological evidence of infection was found in 12 of 82 (15%) infants aged less than 20 months; this increased to 62 of 135 (46%) in those aged 40-60 months. Positive serology was found in 41 of 77 (53%) infants with chronic diarrhoea and malnutrition (mean age 19 months, range 5-36) compared with 18 of 70 (26%) of age matched healthy controls and nearly a quarter (12/49, 24%) of age matched undernourished (marasmic) subjects. These data show that infection with H pylori is common in the Gambia and that in infancy this infection is associated with chronic diarrhoea and malnutrition.
authors.affiliation: MRC Laboratories, Fajara, The Gambia.
authors.forename: P B
authors.initials: PB
authors.lastname: Sullivan
authors.forename: J E
authors.initials: JE
authors.lastname: Thomas
authors.forename: D G
authors.initials: DG
authors.lastname: Wight
authors.forename: G
authors.initials: G
authors.lastname: Neale
authors.forename: E J
authors.initials: EJ
authors.lastname: Eastham
authors.forename: T
authors.initials: T
authors.lastname: Corrah
authors.forename: N
authors.initials: N
authors.lastname: Lloyd-Evans
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D002167:Campylobacter / Q000276:immunology*; D002169:Campylobacter Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003967:Diarrhea / Q000209:etiology*; D004724:Endoscopy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005714:Gambia / Q000453:epidemiology; D005756:Gastritis / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009748:Nutrition Disorders / Q000209:etiology*; D012424:Rural Population; D012698:Serologic Tests / Q000379:methods
chemical_list: D000907:Antibodies, Bacterial