Modification to a commercial immunoradiometric assay permitting intraoperative monitoring of parathyroid hormone levels.
We describe a modification to a commercially available immunoradiometric assay which reduces the turnaround time for parathyroid hormone (PTH) measurement to 1 h and permits intraoperative monitoring during parathyroidectomy. Alterations in PTH concentrations following removal of parathyroid tissue are compared with those of calcium, ionised calcium and phosphate. PTH measurements obtained intraoperatively permit definitive conclusions about the success of the operation within 1 h of sampling, allowing re-exploitation of the gland to take place immediately if necessary.
Ryan
M F
MF
Clinical Chemistry Department, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
Jones
S R
SR
Barnes
A D
AD
D002118:Calcium / Q000097:blood; D006801:Humans; D006961:Hyperparathyroidism / Q000601:surgery; D015592:Immunoradiometric Assay; D007432:Intraoperative Period; D007700:Kinetics; D008991:Monitoring, Physiologic; D010280:Parathyroid Glands / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood*; D010710:Phosphates / Q000097:blood; D013514:Surgical Procedures, Operative
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium