Effects of acute or chronic carbamazepine on experimentally-induced conflict in the rat.
The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an anti-conflict-effect for this drug. No tolerance to the anti-punishment-effect was seen after chronic carbamazepine administration.
Almeida
R N
RN
Departamento de Psicobiologia, Escola Paulista de Medicina, Sao Paulo, Brasil.
Leite
J R
JR
D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D002220:Carbamazepine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003220:Conflict, Psychological; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002220:Carbamazepine