Calcific aortic stenosis in twins: a clue to its pathogenesis?
A pair of identical twins presented almost simultaneously at age 62 years with calcific aortic stenosis requiring surgery, one with bicuspid and one with tricuspid aortic valve. This suggests that bicuspid morphology may perhaps not be the cause, but may be a genetically linked marker of an inherited predisposition to calcific stenosis.
Lewis
N P
NP
Department of Cardiology, University of Wales College of Medicine, Cardiff, U.K.
Henderson
A H
AH
D001021:Aortic Valve / Q000002:abnormalities; D001024:Aortic Valve Stenosis / Q000235:genetics*; D002114:Calcinosis / Q000235:genetics; D004200:Diseases in Twins; D006801:Humans; D008297:Male; D008875:Middle Aged; D014427:Twins; D014430:Twins, Monozygotic