title: Immunologic consequences of taurine deficiency in cats.
abstract: Our results show that a lack of taurine in the diet of cats results in a significant leukopenia, a shift in the percentage of polymorphonuclear and mononuclear leukocytes, an increase in the absolute count of mononuclear leukocytes, and a change in the sedimentation characteristics of white cells. Functional studies of polymorphonuclear cells isolated from cats fed taurine-free diets show a significant decrease in the respiratory burst as measured by chemiluminescence as well as a decrease in phagocytosis of Staphylococcus epidermis compared to cats fed the same diet containing taurine. In addition, serum gamma globulin in cats fed taurine-free diets was significantly increased compared to taurine-supplemented cats, indicating that other immune cells may be affected by taurine deficiency. Histological examination of lymph nodes and spleen revealed regression of follicular centers with depletion of reticular cells, mature and immature lymphocytes (B cell areas), as well as mild extravascular hemolysis. These results indicate that there are profound immunologic consequences in cats with prolonged taurine deficiency.
authors.affiliation: NY State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
authors.forename: G
authors.initials: G
authors.lastname: Schuller-Levis
authors.forename: P D
authors.initials: PD
authors.lastname: Mehta
authors.forename: R
authors.initials: R
authors.lastname: Rudelli
authors.forename: J
authors.initials: J
authors.lastname: Sturman
mesh_terms: D000818:Animals; D002415:Cats; D002469:Cell Separation; D004032:Diet; D004586:Electrophoresis / Q000379:methods; D005260:Female; D007107:Immune System / Q000473:pathology / Q000503:physiopathology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D007970:Leukopenia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D008163:Luminescent Measurements; D008198:Lymph Nodes / Q000473:pathology / Q000503:physiopathology; D010587:Phagocytosis; D012162:Retinal Degeneration / Q000473:pathology / Q000503:physiopathology; D013154:Spleen / Q000473:pathology / Q000503:physiopathology; D013654:Taurine / Q000494:pharmacology*
chemical_list: D013654:Taurine