[The effect of the combined use of cryosurgery and hyperthermia on an experimental tumor process].
The antitumour efficacy of a single cryosurgery use in combination with hyperthermia was studied in 165 mice with the Lewis carcinoma, sarcoma 180 and 169 rats with Guérin's carcinoma and sarcoma 45. A considerable decrease in the recurrence frequency was observed irrespective of the histological type of the primary tumour. The haemostasis-associated expressed hypoxia has been established to arise in tumour tissues after cryodestruction. A day after the cryodestruction a shift to alkaline pH in the tumour tissue has been observed along with hypoxia. The above conditions possibly specify the high antitumour efficacy of a combined use of the cryosurgery and hyperthermia.
Kuz'menko
A P
AP
Todor
I N
IN
Mosienko
V S
VS
D000818:Animals; D003131:Combined Modality Therapy; D003452:Cryosurgery; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy*; D010101:Oxygen Consumption; D010313:Partial Pressure; D011184:Postoperative Period; D051381:Rats; D013997:Time Factors
Vliianie kombinirovannogo primeneniia kriokhirurgii i gipertermii na opukholevyĭ protsess v éksperimente.