title: Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease.
abstract: Serum levels of interleukin-6 (IL-6) were determined in 97 patients with clinically diagnosed Alzheimer's disease and 79 age- and sex-matched control subject. Median serum levels of IL-6 did not differ significantly between Alzheimer patients (8.6 U/ml) and controls (8.2 U/ml). Median levels of serum IL-6 were similar for sporadic and familial patients. The concentration of IL-6 was not associated with the severity of the dementia or the duration of the disease since first symptoms. According to these observations there is no evidence for a significant elevation in serum IL-6 in Alzheimer's disease.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: L
authors.initials: L
authors.lastname: Nagelkerken
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged
chemical_list: D015850:Interleukin-6