Hemodynamic effect of the metallopurpurin SnET2 and light on transplantable FANFT induced bladder tumor.
Changes in blood flow to transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide induced bladder tumors growing subcutaneously in the flanks of Fischer CDF (F344/CrlBR) rats were measured after photodynamic therapy with the photosensitizer tin (II) etiopurpurin dichloride using the radioactive microsphere technique. As with the other photosensitizers, hematoporphyrin derivative and chloroaluminum tetrasulfophtalocyanine, tin (II) etiopurpurin dichloride and light caused a rapid decrease in tumor blood flow in this tumor model. The decrease in blood flow occurred whether the vehicle for photosensitizer delivery was an emulsion or a liposome. Systemic heparinization of animals prior to light treatment did not alter changes in tumor blood flow.
Selman
S H
SH
Department of Surgery (Urology), Medical College of Ohio, Toledo 43699.
Qin
B S
BS
James
H R
HR
Keck
R W
RW
Garbo
G M
GM
Morgan
A R
AR
D000818:Animals; D004337:Drug Carriers; D004655:Emulsions; D005200:FANFT; D006493:Heparin / Q000494:pharmacology; D008081:Liposomes; D008297:Male; D009368:Neoplasm Transplantation; D011166:Porphyrins / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000098:blood supply* / Q000139:chemically induced
D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D011166:Porphyrins; C063166:tin etiopurpurin; D005200:FANFT; D006493:Heparin