Effect of prolonged galactose consumption on galactose tolerance in young healthy humans.
This study was carried out on two groups of healthy young subjects. One group (n = 8) was given a single oral dose of galactose (0.5 g/kg body weight), and a single measurement of blood galactose was made 40 min later. A second group (n = 16) was given a daily supplement of 0.5 g/kg galactose for 15 days, and blood galactose and galactitol were measured. On the first day of the test period, some subjects seemed to tolerate galactose less well than others: galactitol appeared in their plasmas and could be related to a significantly higher galactosaemia than that of subjects without detectable galactitol in the plasma. However, after 15 days of galactose intake, the less galactose-tolerant subjects appeared to have adapted, as indicated by the significant decrease in the blood galactose and the disappearance of galactitol. No change was found in the galactose-tolerant subjects. No significant difference was found between males and females.
Birlouez-Aragon
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I
Laboratoire de Nutrition Humaine, Institut National Agronomique Paris-Grignon, Thiverval-Grignon, France.
Alloussi
S
S
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D004376:Galactitol / Q000097:blood*; D005686:Galactokinase / Q000378:metabolism; D005690:Galactose / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005693:Galactosemias / Q000097:blood / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D008297:Male; D012737:Sex Factors; D013402:Sugar Alcohols / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D013402:Sugar Alcohols; D004376:Galactitol; D005686:Galactokinase; D005690:Galactose