Progesterone side-chain degradation beside hydroxylation with Rhizopus nigricans depends on the presence of nutrients.
In the absence of nutrients, Rhizopus nigricans transforms progesterone into a mixture of 11 alpha-hydroxy-4-androstene-3,17-dione and 11 alpha-hydroxy-1,4-adrostadiene-3,17-dione. The same mixture is obtained by the transformation of testosterone and its acetate.
Pokorná
J
J
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague.
Kasal
A
A
D000730:Androstadienes / Q000378:metabolism; D000735:Androstenedione / Q000031:analogs & derivatives / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D006900:Hydroxylation; D015394:Molecular Structure; D011374:Progesterone / Q000378:metabolism*; D012233:Rhizopus / Q000378:metabolism*
D000730:Androstadienes; D003470:Culture Media; D000735:Androstenedione; D011374:Progesterone; C003582:11-hydroxyandrostenedione; C063199:11-hydroxy-1,4-androstadiene-3,17-dione