title: Syndrome of the posterior and anterior root in a late isolated CNS relapse of c-ALL. Case report.
abstract: A 15 year-old girl who had c-ALL diagnosed in 1982 was presented in our clinic suffering from an ascended flaccid paresis and dysaesthesia of both legs. These are typical symptoms of polyradiculitis of the nerve roots L2-S2. A lumbal puncture revealed a pleocytosis with lymphoblasts which were up to 40% CD10 (cluster of differentiation) up to 70% CD19 and TdT (terminal transferase) positive. The diagnosis of late isolated CNS relapse was made. It is assumed that local residual infiltrations of leukemic cells into the nerve roots L2-S2 got into cell cycle and caused these rare CNS leukemia symptoms. Therefore the value of a craniospinal irradiation to prevent a CNS and systemic relapse is discussed.
authors.affiliation: Department of Paediatrics, Free University of Berlin, West Germany.
authors.forename: E
authors.initials: E
authors.lastname: Baumgarten
authors.forename: R
authors.initials: R
authors.lastname: Fengler
authors.forename: K
authors.initials: K
authors.lastname: Brockmeier
authors.forename: C
authors.initials: C
authors.lastname: Domeyer
authors.forename: U
authors.initials: U
authors.lastname: Schulte-Overberg
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmid
authors.forename: D
authors.initials: D
authors.lastname: Scheffner
authors.forename: G
authors.initials: G
authors.lastname: Henze
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D013118:Spinal Cord Diseases / Q000209:etiology*; D013126:Spinal Nerve Roots / Q000473:pathology*; D013577:Syndrome