An evaluation of the anticonvulsant effects of vitamin E.
The anticonvulsant effects of D-alpha-tocopherol (vitamin E) were studied in 4 animal seizure models: the Metrazol threshold model (MET), the maximal electroshock model (MES), the kindling model (well-established seizures), and the ferrous chloride model. Vitamin E failed to antagonize seizures in the MES, MET, or the kindling models. It was, however, able to significantly delay the onset of electrographic seizures in the intracerebral ferrous chloride model. Thus, vitamin E shows activity in the ferrous chloride model, but not in the animal models commonly used to screen for anticonvulsant drug actions.
Levy
S L
SL
Dept. of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
Burnham
W M
WM
Hwang
P A
PA
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D005296:Ferrous Compounds; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D014810:Vitamin E / Q000627:therapeutic use*
D000927:Anticonvulsants; D005296:Ferrous Compounds; D014810:Vitamin E; C029451:ferrous chloride; D010433:Pentylenetetrazole