Ethanol interoceptive cue and sleep-time duration in HAS and LAS selectively bred rats.
The drug discrimination paradigm was used to evaluate the effects of selective breeding for differential sensitivity to the hypnotic effects of ethanol. Tenth generation high alcohol sensitive (HAS) and low alcohol sensitive (LAS) rats were trained to discriminate between ethanol (0.6 g/kg, IP) and saline vehicle on a VR-5 schedule of reinforcement. The animals were tested with 0.15, 0.3, and 0.9 g/kg ethanol following 40, 50, and 60 training sessions. Sleep-time, tested before and following discrimination training, did not change for the HAS and LAS animals. Dose-response functions showed differences between the HAS and LAS phenotypes after 40 training sessions but not after 50 sessions or after 60 sessions.
Krimmer
E C
EC
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
D000818:Animals; D001947:Breeding; D003463:Cues; D004193:Discrimination Learning; D000431:Ethanol / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D008297:Male; D010641:Phenotype; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013045:Species Specificity; D013997:Time Factors
D006993:Hypnotics and Sedatives; D000431:Ethanol