title: Cimetidine-associated adverse reaction.
abstract: Cimetidine, a histamine2-receptor antagonist, is used in the treatment and prophylaxis of peptic ulcer disease. Its use is relatively free of serious adverse reactions and only a few accounts of hypersensitivity exist. We report a case of intravenous cimetidine-associated adverse reaction characterized by junctional rhythm, bradycardia, and hypotension apparently not secondary to rapid intravenous cimetidine infusion. The adverse reaction was reproduced upon rechallenge. No previous accounts of this reaction appear clearly defined in the literature nor have such reactions been confirmed by rechallenge.
authors.affiliation: Department of Pharmacy Services, Memorial Medical Center, Springfield, IL 62781.
authors.forename: E J
authors.initials: EJ
authors.lastname: Drea
authors.forename: A H
authors.initials: AH
authors.lastname: Mutnick
authors.forename: W
authors.initials: W
authors.lastname: Lam
authors.forename: D P
authors.initials: DP
authors.lastname: Palazzolo
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000503:physiopathology; D002927:Cimetidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010437:Peptic Ulcer / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D002927:Cimetidine