Effects of pinacidil on isolated human corpus cavernosum penis.
Intracavernous injection of vasoactive agents causing vasodilatation is widely recognized in the diagnosis and treatment of erectile dysfunction. However, papaverine, the drug most commonly used for this purpose, may produce priapism and fibrotic lesions, and alternatives without these disadvantages are desirable. In this study we investigated the effects of pinacidil, a vasodilator drug supposed to act through the opening of K+ channels, on isolated human corpus cavernosum penis. Besides abolishing spontaneous contractile activity, pinacidil effectively relaxed preparations precontracted by noradrenaline 10(-6) M and inhibited contractions induced by electrical field stimulation of nerves. Furthermore, pinacidil depressed contractions induced by low-K+ solutions (less than or equal to 20 mM) and concentration-dependently increased the efflux of 86Rb from preloaded tissue. The results suggest that pinacidil is effective in relaxing isolated human erectile tissue, probably by way of increased K+ permeability and subsequent hyperpolarization. Clinical testing seems justified in order to find out if K(+)-channel openers can be used in the pharmacological treatment of impotence.
Holmquist
F
F
Department of Clinical Pharmacology, University Hospital, Lund, Sweden.
Andersson
K E
KE
Hedlund
H
H
D000368:Aged; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010413:Penis / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D020110:Pinacidil; D012414:Rubidium Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics; D014665:Vasodilator Agents / Q000494:pharmacology*
D006146:Guanidines; D012414:Rubidium Radioisotopes; D014665:Vasodilator Agents; D020110:Pinacidil; D009638:Norepinephrine