title: Paracentric inversion inv(11)(q21q23) in The Netherlands.
abstract: We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation.
authors.affiliation: Institute of Human Genetics, Free University, Amsterdam, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Madan
authors.forename: M H
authors.initials: MH
authors.lastname: Pieters
authors.forename: L P
authors.initials: LP
authors.lastname: Kuyt
authors.forename: C J
authors.initials: CJ
authors.lastname: van Asperen
authors.forename: J M
authors.initials: JM
authors.lastname: de Pater
authors.forename: A J
authors.initials: AJ
authors.lastname: Hamers
authors.forename: K B
authors.initials: KB
authors.lastname: Gerssen-Schoorl
authors.forename: T W
authors.initials: TW
authors.lastname: Hustinx
authors.forename: A S
authors.initials: AS
authors.lastname: Breed
authors.forename: J O
authors.initials: JO
authors.lastname: Van Hemel
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000235:genetics; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012737:Sex Factors