title: Pulmonary function, airway responsiveness, and respiratory symptoms in asthmatics following exercise in NO2.
abstract: Two experiments were conducted to determine respiratory responses of persons with asthma performing intermittent moderate exercise while exposed to low concentrations of NO2. In the first, preliminary experiment, 13 male subjects, aged 19-35, with mild asthma were exposed on separate days in a chamber (natural breathing, 20 degrees C, 40% RH) to 0.30 ppm NO2 and to a control or "clean air" exposure (0.0 ppm NO2). Exposure included three 10-min periods of moderate treadmill exercise (VE = 44.5 liter/min), each followed by symptom measurement and pulmonary function testing. The average decrease in FEV1 following the initial 10 min exercise in 0.30 ppm was 11% which was significantly greater (p less than 0.05) than that observed in clean air (7%). Differences in FVC and SRaw were not significantly different at this time. Slight cough and dry mouth and throat were apparent only after the first exercise in NO2. After the second and third exercises, decreases in FEV1 and FVC and increases in SRaw were significantly greater in 0.30 than in 0.0 ppm NO2. Individual subject responses were variable. These results suggested that some asthmatics who perform moderate exercise while exposed to 0.30 ppm NO2 may experience bronchoconstriction and reduction in spirometric performance. Because of these preliminary findings, a more comprehensive, concentration-response experiment was conducted. Twenty-one male volunteers with mild asthma were exposed for 75 min with natural breathing to 0.0, 0.15, 0.30, and 0.60 ppm NO2. Exposure included three 10-min periods of moderate treadmill exercise (VE = 43 liter/min), each exercise followed by symptoms measurement and pulmonary function testing. In addition, airway responsiveness was measured two hr after each exposure by methacholine bronchial challenge testing. In the control exposures (0.0 ppm NO2), the exercise alone caused substantial decrements in pulmonary function. These decrements (as measured by decreases in FEV1 and FVC, and increases in SRaw) were not increased relative to the control exposure after any exercise session in any concentration of NO2. Furthermore, there was no overall group-averaged indication of a concentration-related effect of the NO2 on pulmonary function. Likewise, symptoms reported after NO2 exposure were not significantly different from those reported in clean air. Group-averaged airway responsiveness after exercise in NO2 was also not different from responsiveness after exercise in clean air. For only two subjects was there any indication of a concentration-related increase in airway responsiveness due to exposure to NO2.(ABSTRACT TRUNCATED AT 400 WORDS)
authors.affiliation: Clinical Research Branch, US Environmental Protection Agency, Research Triangle Park, NC.
authors.forename: L J
authors.initials: LJ
authors.lastname: Roger
authors.forename: D H
authors.initials: DH
authors.lastname: Horstman
authors.forename: W
authors.initials: W
authors.lastname: McDonnell
authors.forename: H
authors.initials: H
authors.lastname: Kehrl
authors.forename: P J
authors.initials: PJ
authors.lastname: Ives
authors.forename: E
authors.initials: E
authors.lastname: Seal
authors.forename: R
authors.initials: R
authors.lastname: Chapman
authors.forename: E
authors.initials: E
authors.lastname: Massaro
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D001249:Asthma / Q000503:physiopathology*; D003080:Cold Temperature; D015444:Exercise; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008688:Methacholine Compounds; D009585:Nitrogen Dioxide / Q000633:toxicity*; D010993:Plethysmography, Whole Body; D012129:Respiratory Function Tests; D014797:Vital Capacity
chemical_list: D008688:Methacholine Compounds; D009585:Nitrogen Dioxide