[Possibility of the development of non-transfusion hemosiderosis in beta-thalassemia, caused by association with HLA-linked hemochromatosis].
The data of HLA-haplotyping were used as an allele marker controlling hereditary hemochromatosis in 23 patients with beta-thalassemia. The results obtained have permitted a conclusion that hemosiderosis in patients with beta-thalassemia may be caused by association of beta-thalassemia gene with hereditary hemochromatosis. Early diagnosis of hyperferremia is of great prognostic importance as the adequate treatment timely conducted can prevent the development of irreversible changes in the patients.
Settarova
D A
DA
Donskov
S I
SI
Manishkina
R P
RP
Krasavtseva
T K
TK
Klinika
E G
EG
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015791:HLA-A3 Antigen / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen / Q000235:genetics; D015793:HLA-B7 Antigen / Q000235:genetics; D006432:Hemochromatosis / Q000150:complications* / Q000235:genetics; D006486:Hemosiderosis / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013789:Thalassemia / Q000150:complications* / Q000235:genetics
D006680:HLA Antigens; D015791:HLA-A3 Antigen; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen; D015793:HLA-B7 Antigen
Vozmozhnost' netransfuzionnogo gemosideroza pri beta-thalassemii, obuslovlennogo assotsiatsieĭ s gemokhromatozom, stseplennym s HLA.