Cerebral oxygen utilization analyzed by the use of oxygen-17 and its nuclear magnetic resonance.
In order to assess the usefulness of oxygen-17, a stable isotope of oxygen, oxygen-17, was administered to rats for studying cerebral oxygen utilization, and the produced metabolic water was detected by 17O-NMR spectroscopy in vitro and an 1H-NMR imaging system in vivo. In the vitro study, the increment in signal amplitude of oxygen-17 was observed in the brain extracted from rats that inhaled oxygen-17 gas. The in vivo study demonstrated that there were changes in the 1H-NMR image intensity of brain of rats that inhaled oxygen-17 gas. These facts indicate that oxygen-17 can serve as a tracer in the study of cerebral oxygen utilization.
Arai
T
T
Department of Anesthesia, Kyoto University Hospital, Japan.
Nakao
S
S
Mori
K
K
Ishimori
K
K
Morishima
I
I
Miyazawa
T
T
Fritz-Zieroth
B
B
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010103:Oxygen Isotopes; D051381:Rats; D011919:Rats, Inbred Strains
D010103:Oxygen Isotopes; D010100:Oxygen