Neuronal dysplasia. Considerations for the pathogenesis and treatment of primary chronic constipation in adults.
Intestinal muscle and the autonomic nervous system constitute a neuromuscular unit. A clinical study was undertaken to seek neurogenic causes of impaired motility affecting the rectosigmoid junction and rectum. Patients with primary chronic constipation were shown by enzyme-histochemical examination of biopsies to have neuronal colonic dysplasia of the rectosigmoid, whereas the latter was normally innervated in healthy controls. The present investigations provide a fresh insight, underpinned by histological findings, into the aetiology of chronic constipation and make a contribution to its operative treatment.
Stoss
F
F
Department of Surgery, Dornbirn Hospital, Austria.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D012809:Colon, Sigmoid / Q000002:abnormalities / Q000196:embryology / Q000294:innervation*; D003248:Constipation / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000002:abnormalities / Q000196:embryology / Q000294:innervation*