title: Percutaneous absorption of benzoic acid across human skin. I. In vitro experiments and mathematical modeling.
abstract: The percutaneous absorption of benzoic acid across human skin in vitro was experimentally and mathematically modeled. Skin partition coefficients were measured over a range of benzoic acid concentrations in both saline and distilled water. The permeation of benzoic acid was measured across isolated stratum corneum, stratum corneum and epidermis, and split-thickness skin. These experiments demonstrated that the stratum corneum was the rate-limiting barrier and that the flux is proportional to the concentration of the undissociated species. The permeation data were analyzed with a comprehensive non-steady-state mathematical model of diffusion across skin. Two adjustable parameters, the effective skin thickness and diffusivity, were fit to the permeation data by nonlinear regression.
authors.affiliation: Department of Chemical Engineering, University of Utah, Salt Lake City 84112.
authors.forename: G E
authors.initials: GE
authors.lastname: Parry
authors.forename: A L
authors.initials: AL
authors.lastname: Bunge
authors.forename: G D
authors.initials: GD
authors.lastname: Silcox
authors.forename: L K
authors.initials: LK
authors.lastname: Pershing
authors.forename: D W
authors.initials: DW
authors.lastname: Pershing
mesh_terms: D001565:Benzoates / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D012869:Skin Absorption
chemical_list: D001565:Benzoates