title: c-myc Oncogene expression in colorectal cancer: its use in prognosis and role in colorectal carcinogenesis.
abstract: Expression of the c-myc oncogene was studied in 35 cases of colorectal cancer. Elevated expression was found in 46% (16/35) of cases. This elevated c-myc expression was not significantly correlated with tumour stage, tumour size, tumour differentiation or carcinoembryonic antigen gene expression, demonstrating that it is not a useful prognostic indicator in colorectal cancer. The role of c-myc in colorectal carcinogenesis is discussed in the light of these findings and of the recent advances in molecular biology.
authors.affiliation: Department of Colorectal Surgery, National University of Singapore.
authors.forename: H S
authors.initials: HS
authors.lastname: Goh
authors.forename: T W
authors.initials: TW
authors.lastname: Soong
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Ho
authors.forename: C R
authors.initials: CR
authors.lastname: Goh
mesh_terms: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D009857:Oncogenes; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005819:Genetic Markers