title: Pretreatment with non-depolarizing neuromuscular blocking agents and suxamethonium-induced increases in resting jaw tension in children.
abstract: We have studied the effect of prior administration of non-depolarizing neuromuscular blocking drugs on suxamethonium-induced increases in masseter muscle tension in 21 children aged 3-10 yr, anaesthetized with nitrous oxide and halothane using supramaximal stimulation of the ulnar nerve and the nerve to masseter. Resting tension and isometric force of contraction were measured in the adductor pollicis and masseter muscles. A sub-paralysing dose of tubocurarine 0.05 mg kg-1, a paralysing dose of atracurium 0.5 mg kg-1 or saline was given, followed 3 min later by suxamethonium 1 mg kg-1. Onset times of suxamethonium and atracurium block were shorter in the masseter than in the adductor pollicis muscle. When preceded by a sub-paralysing dose of tubocurarine, suxamethonium produced an increase in masseter tension (47 (SEM 15) g) similar to that produced by suxamethonium alone (59 (13) g). Prior administration of a paralysing dose of atracurium almost abolished this increase in tension (2.5 (2.5) g) (P less than 0.05 vs saline). The tension increase in adductor pollicis was 0, 3.2 (2.2) and 5.9 (1.1) g in the atracurium, tubocurarine and saline groups, respectively. Tubocurarine and atracurium prevented muscle fasciculations in all patients. It was concluded that increased muscle tone is a normal response to suxamethonium and is greater in the masseter than adductor pollicis. Sub-paralysing doses of non-depolarizing neuromuscular blockers have little effect, in contrast with paralysing doses. This suggests that the effect is mediated via postsynaptic receptors.
authors.affiliation: Department of Anaesthesia, Montreal Children's Hospital, Quebec, Canada.
authors.forename: C E
authors.initials: CE
authors.lastname: Smith
authors.forename: J M
authors.initials: JM
authors.lastname: Saddler
authors.forename: J C
authors.initials: JC
authors.lastname: Bevan
authors.forename: F
authors.initials: F
authors.lastname: Donati
authors.forename: D R
authors.initials: DR
authors.lastname: Bevan
mesh_terms: D000556:Ambulatory Surgical Procedures; D000769:Anesthesia, Inhalation; D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects*; D008410:Masticatory Muscles / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D013390:Succinylcholine / Q000494:pharmacology*; D013997:Time Factors; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D001279:Atracurium; D013390:Succinylcholine; D014403:Tubocurarine