Study of alpha-thalassemia in northeastern Thailand at the DNA level.
The frequency of alpha-thalassemias in a general population sample from northeastern Thailand and in an Austroasiatic group with high frequencies of hemoglobin E and beta-thalassemia, the So, was estimated using DNA techniques. Among 64 healthy adult subjects from the Khonkaen and Ubol areas, the following haplotype frequencies were determined: alpha alpha, 0.742; -alpha 3.7 (subtype I), 0.148; -alpha 4.2, 0.016; -alpha del, 0.008; alpha Constant Spring alpha, 0.055; --SEA, 0.023, and alpha alpha alpha (triplicated alpha-globin gene), 0.008. In the So group, the combined frequency of alpha-thalassemia chromosomes was 0.525.
Hundrieser
J
J
Department of Human Genetics, Medizinische Hochschule Hannover, FRG.
Laig
M
M
Yongvanit
P
P
Sriboonlue
P
P
Sanguansermsri
T
T
Kühnau
W
W
Pape
M
M
Flatz
G
G
D005787:Gene Frequency; D005838:Genotype; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D013785:Thailand; D013789:Thalassemia / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D005914:Globins; C035541:Hemoglobin Constant Spring