Pharmacokinetic and pharmacodynamic interaction between the antidepressant tianeptine and oxazepam at steady-state.
To assess if any pharmacokinetic or pharmacodynamic interaction at steady-state occurs between the new antidepressant tianeptine and a benzodiazepine (oxazepam) following multiple oral dosing of both drugs, 12 healthy male volunteers entered a balanced three-way double blind cross-over study. Tianeptine (12.5 mg) and/or oxazepam (10 mg) were given three times daily for 4 days. Pharmacokinetic data within a dosing interval at steady-state showed that there were no statistically significant changes in the pharmacokinetics of either tianeptine (and its two major metabolites) or oxazepam when both drugs were co-administered. Psychometric data showed that there was no synergistic negative interaction between the two drugs and that their combination may result in beneficial effects on "alertness" and "happiness".
Toon
S
S
Medeval, University of Manchester, UK.
Holt
B L
BL
Langley
S J
SJ
Mullins
F G
FG
Rowland
M
M
Halliday
M S
MS
Salvadori
C
C
Delalleau
B
B
D000328:Adult; D000339:Affect / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D010076:Oxazepam / Q000493:pharmacokinetics / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D013841:Thiazepines / Q000493:pharmacokinetics / Q000494:pharmacology*
D013841:Thiazepines; C050504:tianeptine; D010076:Oxazepam