[Structural and functional status of chromatin in the cerebral cortex neurons after circulatory arrest in the rat].
On the 4th day after revivification of rats, subjected to blood circulation arrest, transcriptional activity of chromatin has been evaluated after Moor's method and the state of histones has been investigated in neuronal nuclei of the III, IV and V layers of the cerebral cortex sensomotor area. Both in intact animals and those, subjected to clinical death, the neurons of the cortical layers examined sharply differ in their transcriptional activity of chromatin. The lowest level of labelling is revealed in the IV, the highest--in the V layer. After reviving the animals the transcriptional activity of chromatin in the neuronal nuclei of the III and V layers increases, and that of extranuclear chromatin--in all cortical layers. Increasing matrix activity occurs mostly in light cells; this demonstrates their greater reactivity than in dark cells. During the postresuscitation period essential changes of chromatin histone component are observed in neuronal nuclei of all the cortical layers studied.
Avrushchenko
M Sh
MSh
Bul'chuk
O V
OV
Grigor'eva
A V
AV
Marshak
T L
TL
Mutuskina
E A
EA
Iarugin
V N
VN
D000818:Animals; D002843:Chromatin / Q000502:physiology / Q000648:ultrastructure*; D006323:Heart Arrest / Q000235:genetics / Q000473:pathology*; D006657:Histones / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure*; D051381:Rats; D012151:Resuscitation; D013003:Somatosensory Cortex / Q000473:pathology*; D014158:Transcription, Genetic / Q000502:physiology
D002843:Chromatin; D006657:Histones
Strukturno-funktsional'noe sostoianie khromatina neĭronov kory bol'shogo mozga posle ostanovki krovoobrashcheniia u krys.