Cat-P300 present after association cortex ablation.
The cat-P300 is a positive endogenous potential, larger to a stimulus when rare than when frequent, with a latency of 200-500 msec. The role of polysensory association cortex, postulated to be important in human P300 generation, was assessed in the cat. EEG was recorded in 13 awake cats from a skull screw at the vertex. Stimuli included frequent (P = 0.80) 1 kHz and rare (P = 0.10) 2 kHz tone pulses with probabilities counterbalanced across 260-trial blocks. After 12 preoperative sessions, bilateral ablations were made of pericruciate cortex (4 cats), anterior lateral and medial suprasylvian gyri (4 cats) and all 3 areas (5 cats). Postoperatively, all 13 cats showed a P300 across 12 recording sessions. Thus polysensory association cortex is not essential for generation of the cat-P300.
Harrison
J B
JB
Department of Physiology, UCLA Medical Center 90024.
Dickerson
L W
LW
Song
S
S
Buchwald
J S
JS
D000161:Acoustic Stimulation; D000818:Animals; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways / Q000502:physiology*; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory; D006801:Humans