Diagnostic problem caused by an atypical creatine kinase isoenzyme in a patient with myocardial infarction.
This report describes the diagnostic problem caused by an atypical immunoglobulin-bound creatine kinase isoenzyme in a patient who had a myocardial infarction. In the presence of this atypical isoenzyme, creatine kinase isoenzyme electrophoresis was of no help in determining whether myocardial infarction had occurred. A diagnosis of myocardial infarction was confirmed by carrying out lactate dehydrogenase isoenzyme electrophoresis and finding the characteristic increase in LD1/LD2 ratio and by following the total creatine kinase, aspartate aminotransferase and lactate dehydrogenase activities over a 5-day period. Further investigations were carried out which characterized the atypical isoenzyme as an uncommon type: creatine kinase-BB bound to immunoglobulin A lambda.
Campbell
B G
BG
Department of Chemical Pathology, Princess Alexandra Hospital, Brisbane.
Jones
B W
BW
Burnet
J
J
D000368:Aged; D000369:Aged, 80 and over; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis*
D007136:Immunoglobulins; D007527:Isoenzymes; D003402:Creatine Kinase