The effect of serum lipid regulation on the development of femoral atherosclerosis in hyperlipidaemia: a non-randomized controlled study.
The development of femoral atheroma after 1 year of treatment with diet and nicotinic acid plus fenofibrate was studied in 45 asymptomatic, hyperlipidaemic, middle-aged male subjects in a non-randomized controlled study. The median serum very low density lipoprotein (VLDL) cholesterol concentration and the low density lipoprotein (LDL) cholesterol concentration were lowered by 67% and 36%, respectively, in the treatment group. The median serum high density lipoprotein (HDL) cholesterol concentration was increased by 23%. Femoral atheroma was estimated by overall atherosclerosis score (OAS). Changes in femoral atherosclerosis were estimated by intrapair comparison of angiograms. Progression was found in 24% and 40% in the treatment and control groups, respectively. Regression occurred in 29% and 0%, respectively. The OAS decrease correlated with reductions in VLDL cholesterol and systolic blood pressure.
Olsson
A G
AG
King Gustaf V Research Institute, Stockholm, Sweden.
Ruhn
G
G
Erikson
U
U
D000328:Adult; D000704:Analysis of Variance; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D001794:Blood Pressure; D015243:Cholesterol, VLDL / Q000097:blood; D003131:Combined Modality Therapy; D004032:Diet; D004341:Drug Evaluation; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000628:therapy; D006951:Hyperlipoproteinemias / Q000150:complications; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use*; D011859:Radiography; D012907:Smoking
D015243:Cholesterol, VLDL; D008055:Lipids; D009525:Niacin