title: Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation.
abstract: A direct-acting mutagen to Salmonella typhimurium TA98 was found to be formed by exposing 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in acetone to sunlight for 60 min. The direct-acting mutagen in the irradiated sample was purified by HPLC and identified as 3,4-dimethyl-2-nitroimidazo-[4,5-f]quinoline (NO2-MeIQ). The yield of NO2-MeIQ from MeIQ was estimated to be 0.3%.
authors.affiliation: Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hirose
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Grivas
authors.forename: S
authors.initials: S
authors.lastname: De Flora
authors.forename: N
authors.initials: N
authors.lastname: Arakawa
authors.forename: M
authors.initials: M
authors.lastname: Nagao
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000302:isolation & purification; D010777:Photochemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009593:Nitroimidazoles; D011804:Quinolines; C064039:3,4-dimethyl-2-nitroimidazo-(4,5-f)quinoline; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline