title: [1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms].
abstract: Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
authors.forename: I G
authors.initials: IG
authors.lastname: Kuznetsov
authors.forename: M M
authors.initials: MM
authors.lastname: Rasulov
authors.forename: A A
authors.initials: AA
authors.lastname: Akabirov
authors.forename: S K
authors.initials: SK
authors.lastname: Suslova
authors.forename: M G
authors.initials: MG
authors.lastname: Voronkov
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008930:Mitochondria, Liver / Q000378:metabolism; D017646:Organosilicon Compounds; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012825:Silicon / Q000494:pharmacology* / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D017646:Organosilicon Compounds; C042292:1-ethoxysilatrane; D002784:Cholesterol; D012825:Silicon
vernacular_title: 1-Etoksisilatran: ul'tserostaticheskiĭ éffekt i ego vozmozhnye mekhanizmy.