Effects of D-timolol and L-timolol eye drops on intraocular pressure and aqueous flow. A dose-response study in normal eyes.
The effect on intraocular pressure of 0.5, 1.0, 2.0 or 4.0% D-timolol and 0.25 or 0.5% L-timolol was determined in healthy volunteers after a single topical application. A dose-response relationship for D-timolol could be established. The effect on a diurnal pressure curve and on aqueous humour production was about twice as large with 0.25% L-timolol as with 4.0% D-timolol.
Alm
A
A
Department of Ophthalmology, University Hospital, Umeå, Sweden.
Koskela
T
T
Taarnhøj
J
J
D000287:Administration, Topical; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011897:Random Allocation; D013237:Stereoisomerism; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*; D014065:Tonometry, Ocular
D013999:Timolol