Phenanthrylalkanoic acids, IV: Syntheses and antiinflammatory activity of 2-, 3-, and 9-phenanthryl- and 9-chloro-3-phenanthryl derivatives of propanoic acid.
The phenanthrylethanols 2a-d were obtained by reduction of the acetyl derivatives 1a-d and converted, through the phenanthrylethyl halides 3a-d and 4b, into the nitriles 5a-d, whose acid hydrolysis afforded the acids of the title, 6a-d. The antiinflammatory activity of these acids was measured on the carrageenin-induced edema and found as 1/3 (6a), 1/43 (6b), 1/5 (6c), and 1/7 (6d) of that of fenbufen.
Fernández
F
F
Departmento de Química Organica, Facultad de Farmacia, Universidad de Santiago, Spain.
González
C
C
Gómez
G
G
López
C
C
Medina
L
L
Calleja
J M
JM
Cano
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010616:Phenanthrenes; D011422:Propionates; D002351:Carrageenan