[Antimutagenic activity of vegetable and fruit extracts against in-vitro benzo(a)pyrene].
About 80% of the juices from twenty vegetables and fruits showed antimutagenic activity when tested in the presence of the mutagen and carcinogen benzo[a]pyrene using the Ames' Salmonella/microsome assay. In a standardized test system juices from raw celeriac, broccoli, red cabbage, carrots, green, peppers, lettuce, asparagus, apricots, red-currants, gooseberries, raspberries, and pineapple showed more than 50% inhibition. Leek, kohlrabi, cucumber, zucchini, French beans, fennel leaves, rhubarb, and sweet cherries were less effective. No antimutagenic activity was detected in onions, Chinese cabbage, radish, and white cabbage. Cooking considerably reduced the antimutagenic activity of celeriac, leek, broccoli, French beans, carrots, asparagus, cherries, and pineapple, but was ineffective or only moderately effective with kohlrabi, zucchini, cucumber, fennel leaves, lettuce, apricots, red-currants, gooseberries, and raspberries.
Edenharder
R
R
Hygiene-Institut, Johannes-Gutenberg-Universität Mainz.
John
K
K
Ivo-Boor
H
H
D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors*; D005638:Fruit; D066298:In Vitro Techniques; D009152:Mutagenicity Tests / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D014675:Vegetables
D010936:Plant Extracts; D001564:Benzo(a)pyrene
Antimutagene Aktivitäten von Gemüse- und Obstextrakten gegenüber Benzo[a]pyren in vitro.