Social isolation increases the stimulatory effect of ethanol on locomotor activity.
The stimulatory effects of low alcohol doses are of great interest because of their role in human drinking and their possible relation to reinforcement from alcohol. The preferred animal model for studying them is the mouse. The effects of various doses of ethanol on locomotor activity were now studied in both group-housed mice and in mice socially isolated for 36-44 weeks. The housing situation was found to have a strong influence: a large stimulatory effect was observed in isolated mice but little effect was seen in group-housed animals. The results suggest that socially isolated mice are more sensitive to the stimulatory effect of ethanol on locomotor activity.
Päivärinta
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Research Laboratories, Alko Ltd., Helsinki, Finland.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011897:Random Allocation; D012934:Social Isolation
D000431:Ethanol