Clinical study of urinary excretion of Ga-67.
Ga-67 urinary excretion was examined in 59 patients. The 72-hour urinary excretion rate ranged from 4.3 to 67.8% of the injected dose. Within the first 24 hours, 60.9% of the 72-hour urinary excretion was excreted. There was no significant difference in the Ga-67 urinary excretion rate between males and females, nor between the Ga-67 positive and negative cases. A significant negative correlation was found between the 72-hour Ga-67 urinary excretion rate and the unsaturated iron binding capacity. Notably, four patients with hyperferremia, which was considered secondary to leukemia and/or chemotherapy or liver cirrhosis, excreted more than 46.8% of Ga-67 within 72 hours. A significant negative correlation was also found between the 72-hour Ga-67 urinary excretion rate and age. Urinary excretion of Ga-67 may be related to the glomerular filtration rate, which decreases with age.
Nakano
S
S
Department of Nuclear Medicine, Center for Adult Diseases, Osaka, Japan.
Hasegawa
Y
Y
Ibuka
K
K
Hashizume
T
T
Noguchi
A
A
Kojima
J
J
Sasakuma
F
F
Ishigami
S
S
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D005710:Gallium Radioisotopes / Q000652:urine*; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000652:urine; D011877:Radionuclide Imaging; D014168:Transferrin / Q000378:metabolism
D005710:Gallium Radioisotopes; D014168:Transferrin; D007501:Iron