Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study.
Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.
Yamashita
I
I
Hokkaido University School of Medicine, Sapporo, Japan.
Ohmori
T
T
Koyama
T
T
Mori
H
H
Boyadjive
S
S
Kielholz
P
P
Gastpar
M
M
Moussaoui
D
D
Bouzekraoui
M
M
Sethi
B B
BB
D000437:Alcoholism / Q000201:enzymology / Q000208:ethnology*; D000445:Aldehyde Oxidoreductases / Q000172:deficiency*; D000431:Ethanol / Q000378:metabolism; D005060:Europe / Q000208:ethnology; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008800:Mexico / Q000208:ethnology; D010679:Philippines / Q000208:ethnology; D012559:Schizophrenia / Q000201:enzymology / Q000208:ethnology; D014944:World Health Organization
D000431:Ethanol; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+)