[The mechanism of in vivo arylamine acetyltransferase activation].
A kinetic analysis of arylamine acetyltransferase activation by prodigiozane, a stimulator of organism unspecific resistance, has been carried out. The change of enzyme activity is associated not with a change of its tissue content, but is due to the appearance of a new isoenzyme with altered rate of product dissociation from the catalytic site under condition when k-1 much greater than kKaT. The effect observed is suggested to be defined by a genetically determined adaptative mobility of organism rather than by genetically determined enzyme synthesis. A search strategy for arylamine acetyltransferase activity regulators is proposed.
Ksenzenko
S M
SM
Ksenzenko
M Iu
MIu
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010641:Phenotype; D011354:Prodigiozan / Q000494:pharmacology; D011817:Rabbits; D013379:Substrate Specificity / Q000187:drug effects
D011354:Prodigiozan; D000123:Acetyltransferases; D001191:Arylamine N-Acetyltransferase
Mekhanizm aktivatsii in vivo arilamin-atsetiltransferazy.