title: Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?
abstract: Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
authors.affiliation: Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Bruguerolle
authors.forename: E
authors.initials: E
authors.lastname: Giaufre
authors.forename: G
authors.initials: G
authors.lastname: Morisson-Lacombe
authors.forename: B
authors.initials: B
authors.lastname: Rousset-Rouviere
authors.forename: C
authors.initials: C
authors.lastname: Arnaud
mesh_terms: D000763:Anesthesia, Caudal; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000097:blood* / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D011229:Preanesthetic Medication; D011485:Protein Binding / Q000187:drug effects
chemical_list: D003975:Diazepam; D002045:Bupivacaine