title: Effects of stimulation of cervical sympathetic trunks with various frequencies on the local cortical cerebral blood flow measured by laser Doppler flowmetry in the rat.
abstract: The effects of electrical stimulation of cervical sympathetic trunks for 1-min duration at supramaximal intensity with various stimulus frequencies on local cortical cerebral blood flow were investigated in urethane-anesthetized rats. Electrical stimulation with low frequency (1-2 Hz) produced a significant increase in local cortical cerebral blood flow during the stimulation. The local cortical CBF reached 111% of the resting value during the stimulation at 10 Hz, and slightly decreased for about 30s after the end of stimulation. High-frequency stimulation (20-30 Hz) produced the short-term increase during the stimulation, which was followed by the dominant and long-lasting decrease, and the local cortical CBF reached 87% (at 30 Hz) of the resting value after the end of stimulation. The response of increase in flow was abolished by intravenous administration of beta adrenergic blocking agent (propranolol, 1.3 mg/kg i.v.), while the response of decrease in flow was abolished by alpha adrenergic blocking agent (phenoxybenzamine, 0.5 mg/kg i.v.).
authors.affiliation: Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Saeki
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Trzebski
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D006935:Hypercapnia / Q000503:physiopathology; D007834:Lasers; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
chemical_list: D010643:Phenoxybenzamine; D011433:Propranolol