Sensitive analysis of plasma physostigmine levels using dual-cell electrochemistry in the redox mode.
A column liquid chromatographic method using dual-electrode, redox electrochemical detection has been developed for measuring plasma and cerebrospinal fluid physostigmine levels. The method is suitable for detecting drug levels in a geriatric population following oral ingestion of sustained-release physostigmine preparations and for determining the pharmacokinetics of these preparations in biological fluids.
Knapp
S
S
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093.
Wardlow
M L
ML
Thal
L J
LJ
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004563:Electrochemistry / Q000379:methods*; D006801:Humans; D010084:Oxidation-Reduction; D010830:Physostigmine / Q000008:administration & dosage / Q000097:blood* / Q000134:cerebrospinal fluid
D010830:Physostigmine