Effect of sodium addition to non-ionic contrast media on cardiac contractile force. Perfusion of the isolated rabbit heart with iohexol and iopentol containing 0 to 154 mmol Na+/l added as NaCl.
Cardiac contractile force after adding NaCl to the non-ionic contrast media iohexol and iopentol was investigated in the isolated rabbit heart. Iodine concentrations of 150, 300 and 350 mg I/ml were used with sodium concentrations ranging from 0 to 154 mmol/l. From physiologic experiences of nutrient solutions it should follow that a sodium-free solution of a non-ionic contrast medium, which also has the lowest hypertonicity, should cause the smallest decrease in contractile force. However, a small amount of sodium added to the contrast medium solutions, in the range of 19.25 to 38.5 mmol/l, caused the least decrease in contractile force. The decrease in contractile force was significantly more pronounced when no sodium was added or when larger amounts of sodium were added. A small amount of sodium also decreases the risk of ventricular fibrillation. Thus there is a possibility that addition of sodium could reduce the adverse effects of cardioangiography.
Bååth
L
L
Department of Diagnostic Radiology, University of Lund, Norway.
Almén
T
T
Oksendal
A
A
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007463:Iodobenzoates / Q000008:administration & dosage*; D007472:Iohexol / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000494:pharmacology; D014283:Triiodobenzoic Acids / Q000008:administration & dosage* / Q000494:pharmacology
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol; D012965:Sodium Chloride; C053571:iopentol