Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization.
We have mapped the thrombospondin gene (THBS1) to a single locus on human chromosome 15 (band q15) and on mouse chromosome 2 (region F). Thrombospondin has been implicated in a variety of cell-matrix and cell-cell interactions. The finding of a single locus suggests that the different functions of thrombospondin are not due to a closely related family of genes. These results also confirm a region of homology between the proximal part of human chromosome 15 and region F of mouse chromosome 2.
Jaffe
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Department of Pathology, University of Washington, Seattle 98195.
Bornstein
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P
Disteche
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CM
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D002884:Chromosomes, Human, Pair 15; D005796:Genes; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D019699:Thrombospondins
D008562:Membrane Glycoproteins; D019699:Thrombospondins