title: Increased vagal cardiac nerve traffic prolongs ventricular refractoriness in patients undergoing electrophysiology testing.
abstract: Stimulation of the vagus nerve in animals causes prolongation of sinus cycle length, atrioventricular nodal conduction and ventricular refractoriness. Vagal stimulation appears to have a protective effect in animal models of sudden death. The electrophysiologic effects of enhanced vagal activity on right ventricular (RV) refractoriness in man have not been studied previously. The comparative effects of enhanced vagal tone (neck suction to -60 mm Hg) on sinus cycle length and RV refractoriness were assessed in 26 patients. The electrophysiologic effects of vagal activation by stimulation of carotid baroreceptors with neck suction were compared to the effect of carotid and aortic baroreceptor stimulation with phenylephrine infusion in 12 patients. During neck suction, mean sinus cycle length (819 +/- 32 ms) was prolonged by 146 +/- 20 ms (p less than 0.0001). The mean RV effective refractory period (ERP) and functional refractory period (FRP) were prolonged by 4 +/- 1 ms and 5 +/- 1 ms (p = 0.0001 and 0.0002, respectively). The mean change in RV ERP and FRP correlated with the peak change in sinus cycle length during neck suction (r = 0.46 and r = 0.58, respectively). During intravenous phenylephrine infusion, the mean change in RV ERP and FRP was 5 +/- 2 ms (p less than 0.04) and 10 +/- 3 ms (p less than 0.01), respectively. These results show that reflex vagal stimulation with neck suction or phenylephrine infusion causes a small but significant prolongation in RV refractoriness. These findings imply that the potential benefits of enhanced vagal tone in preventing sudden death may be indirectly mediated by changes in ventricular refractoriness.
authors.affiliation: Department of Medicine, Veterans Adminstration Medical Center, Richmond, Virginia.
authors.forename: K A
authors.initials: KA
authors.lastname: Ellenbogen
authors.forename: M L
authors.initials: ML
authors.lastname: Smith
authors.forename: D L
authors.initials: DL
authors.lastname: Eckberg
mesh_terms: D002304:Cardiac Pacing, Artificial; D002346:Carotid Sinus / Q000502:physiology*; D004594:Electrophysiology; D006321:Heart / Q000294:innervation*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine; D010812:Physical Stimulation; D012018:Reflex / Q000502:physiology; D013268:Stimulation, Chemical; D013396:Suction; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D010656:Phenylephrine