title: Influence of N substitution on antimycobacterial activity of ciprofloxacin.
abstract: Ciprofloxacin analogs with various substitutions on the piperazine nitrogen were tested against several mycobacteria. In contrast to what has been found with other gram-positive and gram-negative bacteria, alkyl analogs such as N-isopropylciprofloxacin were shown to be significantly more active than ciprofloxacin. MICs of 0.125 microgram/ml against Mycobacterium tuberculosis were found.
authors.affiliation: Department of Pharmaceutical Sciences, University of Antwerp, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Haemers
authors.forename: D C
authors.initials: DC
authors.lastname: Leysen
authors.forename: W
authors.initials: W
authors.lastname: Bollaert
authors.forename: M Q
authors.initials: MQ
authors.lastname: Zhang
authors.forename: S R
authors.initials: SR
authors.lastname: Pattyn
mesh_terms: D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D002939:Ciprofloxacin