Effects of capsaicin (C) and dihydrocapsaicin (DC) on serum ethanol (ET) concentration of ET treated CF-1 mice.
In this study adult male CF-1 mice were treated on a daily basis as follows: Group A - controls, Group B - ethanol (ET) treated (1.25 g ET/kg body weight (b.wt.], Group C - ET plus 4 mg Capsaicin (C)/kg b.wt., and Group D - ET plus 4 mg dihydrocapsaicin (DC)/kg b.wt. At the end of the sixth week experimental period the animals were anesthetized, exsanguinated and hepatectomized. Our study suggests that ET administered at the rate of 1.25 g ET/kg b.wt. reaches a mean serum value of 43 + 14 mg/dL within 15 minutes. In addition, chronic ET ingestion significantly decreases mean hepatic glycogen content and mean serum triglyceride concentration of the animals. Conjoint administration of ET plus C decreases significantly mean body weight and mean ET and the triglyceride concentration of the serum. Prolonged ET ingestion plus DC administration decreases mean wet liver weight and lowers significantly the mean serum ET, cholesterol and triglyceride concentrations of CF-1 mice.
Negulesco
J A
JA
Department of Anatomy, College of Medicine, Ohio State University, Columbus 43210.
Noel
S A
SA
Delphia
J M
JM
Boggs
M T
MT
Davis
D H
DH
D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D000431:Ethanol / Q000097:blood*; D008099:Liver / Q000187:drug effects; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D008112:Liver Glycogen; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol; D002211:Capsaicin; C012906:dihydrocapsaicin