[Effect of nifedipine and urapidil on autoregulation of cerebral circulation in the presence of an intracranial space occupying lesion].
We investigated in dogs with an intracranial space occupying lesion the effects of the antihypertentive agents nifedipine and urapidile on intracranial pressure (ICP) and intracerebral autoregulation. During the application of nifedipine the ICP rose significantly whereas urapidile had no influence on the ICP. By continuous angiotensin infusion the mean arterial pressure was raised by 50% by which a simultaneous increase of the ICP could be seen in the nifedipine group, whereas the urapidile group remained unaffected.
Wüsten
R
R
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfälischen Wilhelms-Universität Münster.
Hemelrijck
J
J
Mattheussen
M
M
Lauwers
T
T
Anger
C
C
Van Aken
H
H
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D007262:Infusions, Intravenous; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*
D000959:Antihypertensive Agents; D010879:Piperazines; D000804:Angiotensin II; C015568:urapidil; D009543:Nifedipine
Der Einfluss von Nifedipin und Urapidil auf die Autoregulation der zerebralen Durchblutung in Gegenwart einer intrakraniellen Raumforderung.