title: [The improvement of immunobiological preparations against leptospirosis. An experimental study of a new concentrated purified vaccine against icterohemorrhagic leptospirosis for human immunization].
abstract: The findings of the study of immunological structure of the population in regions endemic for leptospirosis indicate that the immune status of humans makes it impossible to obtain titrated blood sera for the preparation of antileptospirosis immunoglobulin. The data obtained in the study of the immunobiological properties of a new concentrated vaccine against icterohemorrhagic leptospirosis show the possibility of using this vaccine for the immunization of donors with the aim of obtaining blood sera to be used as raw material for the production of immunobiological preparations.
authors.forename: E A
authors.initials: EA
authors.lastname: Iagovkin
authors.forename: N I
authors.initials: NI
authors.lastname: Kostina
authors.forename: B F
authors.initials: BF
authors.lastname: Vachaev
authors.forename: T P
authors.initials: TP
authors.lastname: Romantsova
authors.forename: V F
authors.initials: VF
authors.lastname: Kondratenko
authors.forename: I E
authors.initials: IE
authors.lastname: Bunin
authors.forename: Z A
authors.initials: ZA
authors.lastname: Gol'denshteĭn
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Anan'ina
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D006224:Cricetinae; D004197:Disease Reservoirs; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D007921:Leptospira interrogans / Q000276:immunology*; D051379:Mice; D011817:Rabbits; D014586:USSR; D014895:Weil Disease / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines
vernacular_title: Sovershenstvovanie immunobiologicheskikh protivoleptospiroznykh preparatov. Eksperimental'noe izuchenie novoĭ kontsentrirovannoĭ ochishchennoĭ vaktsiny protiv ikterogemorragicheskogo leptospiroza dlia immunizatsii liudeĭ.