[Prophylaxis of cystoid macular edema after cataract surgery. Observation of an application of Chibro-Amuno].
Report on the safety and efficacy of the prostaglandin synthesis inhibitor Chibro-Amuno 3 for the prevention of cystoid macular edema in 1,263 eyes operated on for cataracts by 70 different surgeons. The patients received the preparation from the day before the operation up to 12 weeks after. The number of women who underwent surgery was nearly twice as high as that of men. There was a frequency peak in age between 75 and 84 years. In 88.5% of all patients, removal of the lens was followed by implantation of an artificial lens, most commonly by a posterior-chamber lens. Extracapsular extraction was performed on nearly 70% of the eyes. Following intracapsular extraction, no artificial lens was implanted in only 13% of the cases. Complications occurred most frequently after phacoemulsification. Cystoid macular edema was found in only 17 patients (1.34%), and a related loss of vision occurred in 2 eyes. Preoperative risk factors appear to have played a role in the development of cystoid macular edema. We observed that it is more likely to develop after intracapsular than after extracapsular extraction. Furthermore, the risk increases with increasing surgery time, and a correlation exists between operation-related complications and the development of Irvine-Gass syndrome. Side effects were observed in 10% of the cases, most of them conjunctival complaints. Corneal damage attributed to Chibro-Amuno 3 healed without complications. Overall, the safety of the preparation is judged to be good.
Dirscherl
M
M
Universitäts-Augenklinik, Marburg/Lahn, BRD.
Straub
W
W
D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000517:prevention & control*; D008297:Male; D011183:Postoperative Complications; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*
D011448:Prostaglandin Antagonists
Zur Prophylaxe des zystoiden Makulaödems nach Kataraktoperationen. Eine Anwendungsbeobachtung von Chibro-Amuno 3.