title: Chronic neurobrucellosis due to Brucella melitensis.
abstract: A 20-year-old male Turkish immigrant to Norway suffering from severe chronic neurobrucellosis with spastic paraplegia and deafness is presented. The diagnosis was established by isolation of Brucella melitensis from cerebrospinal fluid (CSF) culture. Brucella antibody agglutination titers were high in serum and CSF. In spite of intensive, prolonged treatment with a combination of trimethoprim-sulfamethoxazole (TPM-SMZ), rifampicin and doxycycline, the course of the illness was characterized by relapses and severe neurological defects.
authors.affiliation: Medical Department, Ullevål University Hospital, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Bucher
authors.forename: P
authors.initials: P
authors.lastname: Gaustad
authors.forename: E
authors.initials: E
authors.lastname: Pape
mesh_terms: D000328:Adult; D000371:Agglutination / Q000276:immunology; D002006:Brucellosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D003638:Deafness / Q000134:cerebrospinal fluid / Q000209:etiology*; D006801:Humans; D008297:Male; D010264:Paraplegia / Q000134:cerebrospinal fluid / Q000209:etiology*; D012293:Rifampin / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014421:Turkey / Q000208:ethnology
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D012293:Rifampin