title: Transient acanthosis nigricans following bone marrow transplantation for lymphoid malignancy.
abstract: Transient acanthosis nigricans (AN) was observed 3 months after bone marrow transplantation (BMT) for lymphoblastic lymphoma. The patient had no endocrine abnormality and had not received any drug known to induce AN. Forty-eight months post-BMT no malignancy recurred or appeared. Although usual hyperkeratosis, papillomatosis and acanthosis were present on skin biopsy, these were associated with the finding of keratinocyte necrosis and CD8+ lymphocytic infiltrate. It is suggested that graft-versus-host disease may be one of the triggers for AN.
authors.affiliation: Service de Medecine D - Maladies du Sang, CHU Angers, France.
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: J P
authors.initials: JP
authors.lastname: Saint-Andre
authors.forename: P
authors.initials: P
authors.lastname: Martiat
authors.forename: M
authors.initials: M
authors.lastname: Gardembas-Pain
authors.forename: M
authors.initials: M
authors.lastname: Boasson
mesh_terms: D000052:Acanthosis Nigricans / Q000209:etiology* / Q000473:pathology; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*