Detection of liver membrane antibodies in patients with non-insulin-dependent diabetes mellitus.
Circulating liver membrane antibodies (LMAb) were examined in 71 patients with non-insulin-dependent diabetes mellitus (NIDDM) without liver dysfunction and 16 cases of KK mouse as a model of obese diabetic animals. LMAb were detected in 10 NIDDM patients (14.1%). Fasting blood glucose, glycosylated serum albumin (G-Alb), and glycosylated hemoglobin A1 (HbA1) levels were compared with LMAb-positive and negative groups. The G-Alb levels and HbA1 levels of the LMAb-positive group were significantly higher (p less than 0.05 and p less than 0.01, respectively) than those of the LMAb-negative group. In addition, there were no differences in histological findings in KK mouse liver between the LMAb-positive and negative cases. These results revealed that the state of continued high blood glucose directly or indirectly influence the autoimmunity and clinical features of NIDDM patients.
Iijima
T
T
Department of Internal Medicine, Urayasu Hospital, Juntendo University School of Medicine, Chiba, Japan.
Thukada
M
M
Sugiura
M
M
Ishi
K
K
Nambu
M
M
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D006801:Humans; D008099:Liver / Q000276:immunology*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008875:Middle Aged
D001323:Autoantibodies