title: A kinetic analysis of the repair of radiation-induced DNA double-strand breaks.
abstract: The repair of radiation-induced DNA double-strand breaks (DSBs) is analyzed kinetically. It is assumed that a fraction of the damaged sites in the DNA duplex are irreparable. The kinetic model takes the effect of radiation dose into account. The analysis of the available experimental data reveals that, although the number of irreparable DSBs is a quadratic function of radiation dose, the normalized number of irreparable DSBs correlates linearly with this variable.
authors.affiliation: Department of Mathematics, Tamkang University, Taiwan, Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Tseng
authors.forename: J P
authors.initials: JP
authors.lastname: Hsu
mesh_terms: D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D007700:Kinetics; D008954:Models, Biological
chemical_list: D004247:DNA