The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation.
The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.
Wiseman
H
H
Department of Biochemistry, University of London, King's College, Strand Campus, UK.
Laughton
M J
MJ
Arnstein
H R
HR
Cannon
M
M
Halliwell
B
B
D000818:Animals; D000975:Antioxidants; D001205:Ascorbic Acid / Q000494:pharmacology; D002712:Chlorides; D005290:Ferric Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D002712:Chlorides; D005290:Ferric Compounds; D013629:Tamoxifen; D001205:Ascorbic Acid; C024555:ferric chloride