title: Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels.
abstract: The cellular mechanisms for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac cancellous bone by a new histomorphometric method in 89 women with osteoporosis (mean age +/- SD, 66 +/- 6 years) and in 32 carefully selected normal postmenopausal women (64 +/- 6 years). In the osteoporotic women, bone resorption rate was increased by 39% (P less than 0.05) at the cellular level and by 67% (P less than 0.05) at the tissue level, whereas bone formation was unchanged at the tissue level but decreased by 14% (P less than 0.01) at the cellular (osteoblast) level. This pronounced remodeling imbalance (P less than 0.001) was probably exacerbated by a 45% increase (P less than 0.1) in activation frequency of new remodeling foci. These abnormalities were associated with a high rate of cancellous bone loss (median, 5.8%/year versus 0.1% year in controls). Thus, accelerated loss of cancellous bone in type I osteoporosis results from the combination of increased bone resorption and inadequate compensation by bone formation.
authors.affiliation: Endocrine Research Unit, Mayo Clinic, Rochester, MD 55905.
authors.forename: E F
authors.initials: EF
authors.lastname: Eriksen
authors.forename: S F
authors.initials: SF
authors.lastname: Hodgson
authors.forename: R
authors.initials: R
authors.lastname: Eastell
authors.forename: S L
authors.initials: SL
authors.lastname: Cedel
authors.forename: W M
authors.initials: WM
authors.lastname: O'Fallon
authors.forename: B L
authors.initials: BL
authors.lastname: Riggs
mesh_terms: D000368:Aged; D001846:Bone Development / Q000502:physiology*; D001862:Bone Resorption / Q000503:physiopathology*; D001842:Bone and Bones / Q000166:cytology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D015203:Reproducibility of Results