title: Antineoplastic agents, 162. Zephyranthes candida.
abstract: The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10(-3) micrograms/ml.
authors.affiliation: Cancer Research Institute, Arizona State University, Tempe 85287-1604.
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: G M
authors.initials: GM
authors.lastname: Cragg
authors.forename: S B
authors.initials: SB
authors.lastname: Singh
authors.forename: J A
authors.initials: JA
authors.lastname: Duke
authors.forename: D L
authors.initials: DL
authors.lastname: Doubek
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D007941:Leukemia P388 / Q000188:drug therapy; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C064338:dihydronarciclasine