title: Ultrastructural changes in synovium and cartilage in experimental hemarthrosis in dogs.
abstract: This paper reports electron-microscopic findings in synovium and cartilage in experimental hemarthrosis in dogs. The results are correlated with the total amount of glycosaminoglycans in the cartilage matrix, measured by the fixed-charge density method. Very early, changes are seen in the synoviocytes, similar to synovitis, and especially phagocytosis of iron-containing particles forming secondary lysosomes or siderosomes. Siderosomes are also a constant feature seen in the chondrocytes, together with changes in the rough endoplasmic reticulum and in the glycogen content, correlating with the changes in the ground substance.
authors.affiliation: Department of Orthopedics, University Hospital, Pellenberg, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Fabry
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000032:analysis / Q000648:ultrastructure*; D004285:Dogs; D006025:Glycosaminoglycans / Q000032:analysis; D006395:Hemarthrosis / Q000473:pathology* / Q000503:physiopathology; D007501:Iron / Q000502:physiology; D013583:Synovial Membrane / Q000648:ultrastructure*
chemical_list: D006025:Glycosaminoglycans; D007501:Iron