Effects of thyroid hormones on serum and cutaneous fatty acid concentrations in dogs.
The effects of thyroid hormones on the serum and cutaneous fatty acid concentration profiles of dogs were evaluated. Thyroidectomized dogs had significant (P less than 0.05) increases in serum oleic acid and linoleic acid concentrations, and decreases in concentration of dihomo-gamma-linolenic acid, arachidonic acid, and other elongation products of fatty acid metabolism. These changes were reversed in response to thyroid hormone replacement. Similar changes were found in cutaneous fatty acid concentration profiles. Thus, in dogs, thyroid hormones may be involved in the regulation of fatty acid delta-6-desaturase activity.
Campbell
K L
KL
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61801.
Davis
C A
CA
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004285:Dogs / Q000097:blood / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D011897:Random Allocation; D012867:Skin / Q000378:metabolism*; D013960:Thyroid Function Tests / Q000662:veterinary; D013965:Thyroidectomy / Q000662:veterinary*; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol; D013974:Thyroxine