[Ethyl benzimidazole carbamate: teratogenic effect and presence in the milk of cows after administration of thiophanate].
After oral administration of 40 mg/kg of thiophanate to dairy cows, the active metabolite, ethyl-1H-benzimidazol-2-yl carbamate (EBC) reached a maximal concentration of 0.44 microgram/ml during the first milking and was eliminated by the mammary gland after 60 h. BCE is teratogenic in rats at doses of over 6.8 mg/kg while thiophanate at doses of up to 148 mg/kg is not. These results indicate that thiophanate treatment for dairy cattle may be questionable.
Delatour
P
P
Laboratoire de biochimie INRA 54 189, Ecole nationale vétérinaire de Lyon, Marcy l'Etoile, France.
Besse
S
S
D000014:Abnormalities, Drug-Induced / Q000662:veterinary*; D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000032:analysis* / Q000633:toxicity; D002219:Carbamates / Q000493:pharmacokinetics*; D002417:Cattle / Q000378:metabolism*; D005260:Female; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000032:analysis*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013875:Thiophanate / Q000008:administration & dosage / Q000493:pharmacokinetics*
D001562:Benzimidazoles; D002219:Carbamates; D013875:Thiophanate; C064231:lobendazole
Benzimidazole carbamate d'éthyle: effet tératogène et présence dans le lait de vache après administration de thiophanate.