[The reaction of vascular endothelial cells in old animals to an increased blood level of angiotensin II].
The comparative morphological investigation of endothelium (E) of femoral arteries in old and young rabbits has revealed quantitative differences in the content of cells differing in their structure and function, and a four-fold increase in the number of cells having some signs of malfunction or injury in the E of old vs. young animals. These peculiarities, as well as different initial functional state of groups of cells, their location in the intima and degree of their compression during a 30 min vasoconstriction induced by angiotensin II (0.5 microgram/kg-1.min-1) predetermine a different degree of injury of endothelial cells. A phasic response of endothelial cells to angiotensin II administration, as well as slow restoration of permeability and autolysis of part of the injured endothelial cells in old animals are revealed. A peculiar pattern of the endothelial injury in old animals at a sharp increase of the blood pressure may account for the causes of the accelerated formation of fibrous-muscular thickenings and lipid strips in arteries of old rabbit at chronic hypertension.
Kopylova
G V
GV
Kozhura
I P
IP
D000367:Age Factors; D000804:Angiotensin II / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005263:Femoral Artery / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009336:Necrosis; D011817:Rabbits; D013997:Time Factors
D000804:Angiotensin II
Reaktsii éndotelial'nykh kletok sosudov starykh zhivotnykh na povyshenie soderzhaniia angiotenzina II v krovi.