Biphenyls, a new class of compound that inhibits platelet-activating factors.
Honokiol (1), a constituent of Magnoliae cortex, and related synthetic biphenyls inhibited the platelet aggregation induced by a few aggregating agents. In particular, compounds 3, 5, and 10 had an inhibitory effect on platelet activating factor (PAF), which provides a new class of PAF inhibitor.
Takeya
T
T
Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Takeuchi
N
N
Kasama
T
T
Mayuzumi
K
K
Fukaya
H
H
Tobinaga
S
S
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D066298:In Vitro Techniques; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D010972:Platelet Activating Factor