[An increase in the incidence of tritium-induced leukoses with the repeated administration of a bacterial lipopolysaccharide].
The incidence of leukoses upon long-term administration of tritium oxide to Wistar rats increased by 15.6% as compared to 2.1% in controls. The repeated injection of bacterial lipopolysaccharide caused a 2.3-fold increase in the occurrence of hemoblastosis induced by the radionuclide mainly due to the increase in the proliferative activity of haemopoietic precursors because of the increased demand for mature cells.
Muksinova
K N
KN
Murzina
L D
LD
Revina
V S
VS
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D006098:Granulocytes / Q000187:drug effects / Q000528:radiation effects; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D007942:Leukemia, Experimental / Q000453:epidemiology* / Q000209:etiology; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012485:Salmonella typhi; D013997:Time Factors; D014316:Tritium / Q000633:toxicity*; D014867:Water; D014869:Water Intoxication
D008070:Lipopolysaccharides; C009136:pyrogenal; D014867:Water; D014316:Tritium; C033961:tritium oxide
Povyshenie chastoty indutsirovannykh tritiem leĭkozov pri povtornom vvedenii bakterial'nogo lipopolisakharida.