[Study of the properties of condensed forms of the complexes of linear and supercoiled DNA with mitoxantrone and bisantrene].
The effect of anthrachinone and anthracene derivatives on linear and circular superstranded molecules of DNA in conditions of their condensation was studied. It was shown that the compounds formed strong intercalation complexes with the molecules of the linear and circular superstranded DNA when the DNA molecules were in the condensed condition. The optical properties of the disperse liquid crystal phases formed of the complexes of the investigated compounds with the molecules of linear double-chain DNA differed. Moreover, the optical properties of the condensed phases formed of the complexes of the compounds with the molecules of linear and circular superstranded DNA also differed. The causes of the differences are discussed.
Salianov
V I
VI
Evdokimov
Iu M
IuM
Palumbo
M
M
D000873:Anthracenes / Q000032:analysis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D004278:DNA, Superhelical / Q000032:analysis* / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents; D008942:Mitoxantrone / Q000032:analysis* / Q000494:pharmacology; D009690:Nucleic Acid Conformation / Q000187:drug effects*
D000873:Anthracenes; D004278:DNA, Superhelical; D007364:Intercalating Agents; C031404:bisantrene; D008942:Mitoxantrone
Issledovanie svoĭstv kondensirovannykh form kompleksov lineĭnykh i kol'tsevykh superspiral'nykh DNK s mitoksantronom i i bisantrenom.