Studies on cytotoxic constituents in pericarps of Mallotus japonicus. IV.
Two new phloroglucinol derivatives, isomallotolerin (1) and isomallotochromanol (2), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-methy l-6- methoxybenzyl)-phlorisobutyrophenone (1) and 6-acetyl-5,7-dihydroxy-8-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzy l)-2,2- dimethyl-3-hydroxychroman (2) from chemical and spectral data. Isomallotolerin and its acetate were found to be cytotoxic to KB cell line.
Arisawa
M
M
Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Fujita
A
A
Hayashi
T
T
Morita
N
N
Kikuchi
T
T
Tezuka
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007564:Japan; D007624:KB Cells / Q000187:drug effects; D010696:Phloroglucinol / Q000302:isolation & purification / Q000494:pharmacology / Q000031:analogs & derivatives; D010946:Plants, Medicinal / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; C064421:isomallotolerin; C064422:isomallotochromanol; D010696:Phloroglucinol