Ileostomy using an interposed ileal segment to function as a 'neocolon'.
A new type of ileostomy was constructed in rats using an interposed ileal (I-I) segment functioning as a neocolon. The effects of this operation in these rats were compared with a control group undergoing conventional ileostomy (I). Rats in the I group lost weight throughout follow-up, whereas rats in the I-I group regained weight and were significantly heavier four weeks after surgery. Transit time from the stomach to the stoma was significantly prolonged in the I-I group (187 +/- 29 minutes) when compared with the I group (141 +/- 17 minutes, P less than 0.01). Serum analysis revealed no significant differences in total protein, lipids, electrolytes (Na, Cl, CO2), and osmolarity between the groups. Biliary bile salt concentration, normalized bile flow, and normalized bile acid output in the I-I group were not different from those in unoperated control rats, suggesting unimpaired bile acid metabolism. These data suggest this operative procedure has the beneficial effects of slowing intestinal transit and promoting postoperative recovery without impairing distal ileal function.
Nakahara
S
S
Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Taylor
C L
CL
Schirmer
B D
BD
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001774:Blood Chemical Analysis; D003106:Colon / Q000601:surgery*; D005772:Gastrointestinal Transit; D007081:Ileostomy / Q000379:methods*; D007082:Ileum / Q000601:surgery*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015430:Weight Gain; D015431:Weight Loss
D001647:Bile Acids and Salts