Effects of Eperisone on Renshaw cells of cats.
Actions of Eperisone (4'-ethyl-2-methyl-3-piperidinopropiophenone; EMPP) on Renshaw cells were investigated on spinal cats. The characteristic high-frequency discharges of Renshaw cells within 20 ms following antidromic ventral root stimulation were depressed while the later responses which follow the earlier responses for 80 ms were enhanced following administration of EMPP. These effects suggest that EMPP has differential effects on nicotinic acetylcholine receptors of the Renshaw cells.
Kato
M
M
Department of Physiology, Hokkaido University School of Medicine, Sapporo, Japan.
Yang
Y H
YH
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D009433:Neural Inhibition / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D010276:Parasympatholytics; D011427:Propiophenones; C030848:eperisone