[Hormonal synergism, maturation of lung structure and surfactant production in the fetal sheep lung].
Simultaneous administration of cortisol, triiodothyronine, and prolactin but not of any of these hormones infused singly or in combination of two, increases pulmonary distensibility and stability to term values in fetal sheep of 125 days gestation. Similar results are obtained with thyrotropin-releasing hormone and cortisol. Measurements of elastin and collagen and discrepancies between concentrations of alveolar surfactant and lung distensibility and stability suggest that maturation of connective tissue plays an important part in fetal lung maturation.
Schellenberg
J C
JC
Postgraduate School of Obstetrics and Gynaecology, University of Auckland, New Zealand.
Liggins
G C
GC
D000818:Animals; D005260:Female; D005325:Fetal Organ Maturity / Q000502:physiology*; D006728:Hormones / Q000502:physiology*; D008168:Lung / Q000196:embryology*; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000096:biosynthesis*; D012756:Sheep
D006728:Hormones; D011663:Pulmonary Surfactants
Hormonaler Synergismus, Reifung des Lungengerüstes und Surfactant Produktion in der fetalen Schaflunge.