title: Gigantecin: a novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, from Goniothalamus giganteus (Annonaceae).
abstract: Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid gamma-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
authors.forename: A
authors.initials: A
authors.lastname: Alkofahi
authors.forename: J K
authors.initials: JK
authors.lastname: Rupprecht
authors.forename: Y M
authors.initials: YM
authors.lastname: Liu
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: D L
authors.initials: DL
authors.lastname: Smith
authors.forename: J L
authors.initials: JL
authors.lastname: McLaughlin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; C064403:gigantecin; C018674:tetrahydrofuran