Increased serum kininase I activity in pregnancy complicated by pre-eclampsia.
Serum kininase I activity was measured in normal pregnancy and pre-eclampsia. The mean value in nonpregnant controls was 180 +/- 25 (SD) nmol/min/ml. Kininase I activity during normal pregnancy significantly increased after week 14, reaching the highest value (240 +/- 20 nmol/min/ml) at weeks 38 and 40. The kininase I activity in pregnancy complicated by severe pre-eclampsia was higher than that in normal pregnancy. The possible role played by elevated kininase I levels in pre-eclampsia was discussed.
Ito
Y
Y
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Mizutani
S
S
Nomura
S
S
Kurauchi
O
O
Kasugai
M
M
Narita
O
O
Tomoda
Y
Y
D000328:Adult; D002268:Carboxypeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D001121:Lysine Carboxypeptidase / Q000097:blood*; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy
D002268:Carboxypeptidases; D001121:Lysine Carboxypeptidase