6-O-carboxymethyl-chitin (CM-chitin) as a drug carrier.
Gel was prepared from 6-O-carboxymethyl-chitin (CM-chitin) by the addition of iron(III) chloride under mild conditions without any organic solvent. The optimal conditions for the gel formation were 15 to 30 mM iron(III) chloride and 0.5 to 0.8 degree of substitution in CM-chitin. The amounts of bovine serum albumin (BSA) and the anticancer drug doxorubicin (DOX) incorporated into CM-chitin gels were more than 80% and 30%, respectively under the conditions described above. The release of BSA or DOX from the gels was observed to be increased by lysozyme digestion in a time-dependent manner. This result indicates that CM-chitin might prove useful as a carrier gel for the sustained release of drugs and cytokines, including vaccines.
Watanabe
K
K
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Saiki
I
I
Uraki
Y
Y
Tokura
S
S
Azuma
I
I
D000818:Animals; D002460:Cell Line; D002686:Chitin / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004337:Drug Carriers; D002686:Chitin; C044872:O-(carboxymethyl)chitin; D004317:Doxorubicin