[Familial nonneoplastic inappropriate thyrotropin secretion].
A follicular thyroid carcinoma was suspected in a 62-year-old woman after the fifth goitre excision for non-neoplastic inappropriate thyrotropin secretion. Small-follicular adenoma could not be excluded histologically. After an attempt at thyrotropin suppression with L-thyroxine, triiodothyronine, D-thyroxine with L-thyroxine, and bromocriptine had failed, lasting if partial decrease in the maximally elevated TSH levels was achieved with triiodothyroacetic acid (TRIAC). One of the patient's three daughters also has non-neoplastic inappropriate thyrotropin secretion and has had two goitre excisions. It is most likely a familial form of inappropriate TSH secretion.
Langer
H J
HJ
Medizinische Klinik und Poliklinik, Universität des Saarlandes, Homburg/Saar.
Leicht
E
E
Koch
B
B
Weinheimer
B
B
Berberich
R
R
Strohfeldt
P
P
Weinges
K F
KF
D002277:Carcinoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006042:Goiter / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012086:Reoperation; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D013964:Thyroid Neoplasms / Q000175:diagnosis; D013965:Thyroidectomy; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000008:administration & dosage; D014284:Triiodothyronine / Q000008:administration & dosage / Q000031:analogs & derivatives
D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid; D013972:Thyrotropin; D013974:Thyroxine
Familiäre, nicht-neoplastische inadäquate Thyreotropin-Inkretion.