The chromosomal complements of cleaved human embryos resulting from in vitro fertilization.
Chromosome preparations were made from 25 cleaved abnormal human embryos at the two- to eight-cell stage after in vitro fertilization. Morphologically, these embryos showed either variable degrees of degeneration or an abnormal number of pronuclei before first cleavage. Among 14 successfully karyotyped embryos, only 3 had a normal chromosomal complement. Eleven showed chromosomal abnormalities, including triploidy, haploidy, and mosaicism. This finding documents a high incidence of chromosomal errors in morphologically abnormal early preimplantation embryos.
Ma
S
S
Department of Obstetrics and Gynaecology, Shaughnessy Hospital, Vancouver, British Columbia, Canada.
Kalousek
D K
DK
Zouves
C
C
Yuen
B H
BH
Gomel
V
V
Moon
Y S
YS
D002869:Chromosome Aberrations; D004622:Embryo, Mammalian; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy