The short- and long-term effect of single high-dose intra-operative electron beam irradiation of retroperitoneal structures--an experimental study in dogs.
Intra-operative electron beam radiotherapy is a new treatment modality. The abdomen is the area of greatest potential applicability of IORT and therefore its effect on retroperitoneal structures was investigated in a canine model. The retroperitoneal structures tolerate 30 to 40 Gy well, with the exception of the radiation-sensitive ureter which showed fibrosis. Twenty to 25 Gy is within the safe dose limits for the clinical application of IORT.
Hoekstra
H J
HJ
Division of Surgical Oncology, Gronigen University Hospital, The Netherlands.
Mehta
D M
DM
Oosterhuis
J W
JW
Westra
P
P
van den Dungen
J
J
Dijkstra
R G
RG
D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D004285:Dogs; D004583:Electrons; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology; D005355:Fibrosis / Q000209:etiology; D007432:Intraoperative Period; D007674:Kidney Diseases / Q000209:etiology; D008159:Lumbar Vertebrae / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D012185:Retroperitoneal Fibrosis / Q000209:etiology; D012187:Retroperitoneal Space / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery; D013125:Spinal Neoplasms / Q000209:etiology; D014513:Ureter / Q000473:pathology