[Nonenzymatic glycosylation of serum albumin and thymic DNA by food monosugars and their natural metabolites that form in the body].
The nonenzymatic glycosylation of human plasma albumin by glucose, fructose, xylose, glucose-6-P, fructose-6-P, 6-PP was studied in vitro. The most manifest differences in the albumin spectrum (250-390 nm) were observed when fructose-6-P and xylose were used. The use of 3H-glucose and 14C-fructose has shown that there are 2 sites for glucose addition, 4 sites for fructose addition and 1 site to which both glucose and fructose can be bound, but glucose is preferable. Calf thymus DNA has 10 sites to which carbohydrate can be bound: 4 for glucose and 6 for fructose, only.
Gapparov
M M
MM
Virovets
O A
OA
D004247:DNA / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D066298:In Vitro Techniques; D009005:Monosaccharides / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism
D004040:Dietary Carbohydrates; D009005:Monosaccharides; D012709:Serum Albumin; D005632:Fructose; D004247:DNA; D014994:Xylose; D005947:Glucose
Nefermentativnoe glikozilirovanie syvorotochnogo al'bumina i DNK timusa pishchevymi monosakharami i ikh estestvennymi metabolitami, obrazuiushchimisia v organizme.