Effect of cisapride on gastric motility.
The effect of cisapride on gastric motility was determined in vitro (gastroduodenal preparation of the guinea pig) and in vivo (conscious dog). In vitro, cisapride (10(-7)-10(-6) M) antagonized induced gastric relaxation. It enhanced the amplitude of gastric peristaltic waves and improved antroduodenal coordination. This effect was prevented by previous administration of atropine or tetrodotoxin indicating that cisapride exerted its effect via facilitation of cholinergic neurotransmission. In vivo, cisapride (0.08-5 mg/kg p.o.) enhanced the amplitude and the coordination of antral, pyloric and duodenal contractions, both in acute and chronic experiments in conscious dogs with force transducers. Cisapride selectively improved motility since it did not affect gastric secretion (basal or stimulated) in dogs with a gastric cannula. Cisapride (0.16-1.25 mg/kg p.o.) accelerated gastric emptying of a liquid and solid test meal in dogs equipped with a gastric or duodenal cannula, in which gastric emptying was delayed by intragastric or intraduodenal administration of oleic acid.


CONCLUSIONS
Cisapride facilitates cholinergic neurotransmission in the gastric wall resulting in selective improvement of motor function and acceleration of delayed gastric emptying.
Schuurkes
J
J
Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse, Belgium.
D000818:Animals; D020117:Cisapride; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014160:Transducers, Pressure
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride