title: Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum.
abstract: This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer matrix pellet into the denervated striatum of rats. Animals that received DA-releasing pellets showed a 50% reduction in apomorphine-induced rotational behavior, and this effect persisted for the 2-month duration of the experiment. The results suggest that the controlled release of DA from an intrastriatal polymer matrix can produce a long-lasting reduction in some of the symptoms associated with DA depletion.
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor.
authors.forename: J B
authors.initials: JB
authors.lastname: Becker
authors.forename: T E
authors.initials: TE
authors.lastname: Robinson
authors.forename: P
authors.initials: P
authors.lastname: Barton
authors.forename: A
authors.initials: A
authors.lastname: Sintov
authors.forename: R
authors.initials: R
authors.lastname: Siden
authors.forename: R J
authors.initials: RJ
authors.lastname: Levy
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000008:administration & dosage / Q000502:physiology*; D004343:Drug Implants; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000378:metabolism / Q000502:physiology*
chemical_list: D004343:Drug Implants; D004298:Dopamine