Contractile effect of oxytocin and 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin in myometrial tissue from non-pregnant and term pregnant women.
The contractile effect of the analogue 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin (carbetocin) on isolated strips from the human myometrium was compared with that of oxytocin. Neither oxytocin nor carbetocin affected contractile activity in strips from non-pregnant women, but both peptides stimulated contractile activity in strips from women at term pregnancy (2 x 10(-11) mol/l, and 10(-10) mol/l, respectively). Thus, carbetocin is almost as potent as oxytocin with regard to stimulating myometrial contractions at term.
Norström
A
A
Department of Obstetrics and Gynecology, University of Göteborg, Sahlgren's Hospital, Sweden.
Andersson
A
A
Vilhardt
H
H
D000328:Adult; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011247:Pregnancy / Q000502:physiology*; D011263:Pregnancy Trimester, Third; D014590:Uterine Contraction / Q000187:drug effects*
D010121:Oxytocin; C020731:carbetocin