title: Biphenyls, a new class of compound that inhibits platelet-activating factors.
abstract: Honokiol (1), a constituent of Magnoliae cortex, and related synthetic biphenyls inhibited the platelet aggregation induced by a few aggregating agents. In particular, compounds 3, 5, and 10 had an inhibitory effect on platelet activating factor (PAF), which provides a new class of PAF inhibitor.
authors.affiliation: Showa College of Pharmaceutical Sciences, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takeya
authors.forename: N
authors.initials: N
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Kasama
authors.forename: K
authors.initials: K
authors.lastname: Mayuzumi
authors.forename: H
authors.initials: H
authors.lastname: Fukaya
authors.forename: S
authors.initials: S
authors.lastname: Tobinaga
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D066298:In Vitro Techniques; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D010972:Platelet Activating Factor