[The effect of propranolol (Obsidan) as well as propranolol and fenoterol (Partusisten) on the motility of the smooth uterus musculature in vitro].
Propranolol (1; Obsidan) relaxes in vitro stripes of smooth muscles of non-pregnant rat's uterus in a concentration dependent manner. In contrast, on uterine muscle stripes of pregnant rats 1 causes small contractions. In an combination of 1 and fenoterol (2; Partusisten) (20:1) 1 prevents the relaxing effect of 2, reported to be an inhibitor of uterine muscle activity. This antagonism is most distinct on stripes of pregnant rat's uterus.
Peiker
G
G
Klinik für Frauenheilkunde und Geburtshilfe, Friedrich-Schiller-Universität Jena.
Mares
J
J
Fleck
C
C
Hasanová
M
M
D000818:Animals; D004338:Drug Combinations; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D004338:Drug Combinations; D005280:Fenoterol; D010121:Oxytocin; D011433:Propranolol
Die Wirkung von Propranolol (Obsidan) sowie von Propranolol und Fenoterol (Partusisten) auf die Motalität der glatten Uterusmuskulatur in vitro.