title: Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.
abstract: The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (+/-)-butane 1, 3-diol, respectively), are described.
authors.affiliation: Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
authors.forename: R P
authors.initials: RP
authors.lastname: Iyer
authors.forename: B
authors.initials: B
authors.lastname: Uznanski
authors.forename: J
authors.initials: J
authors.lastname: Boal
authors.forename: C
authors.initials: C
authors.lastname: Storm
authors.forename: W
authors.initials: W
authors.lastname: Egan
authors.forename: M
authors.initials: M
authors.lastname: Matsukura
authors.forename: S
authors.initials: S
authors.lastname: Broder
authors.forename: G
authors.initials: G
authors.lastname: Zon
authors.forename: A
authors.initials: A
authors.lastname: Wilk
authors.forename: M
authors.initials: M
authors.lastname: Koziolkiewicz
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D009838:Oligodeoxyribonucleotides; D013873:Thionucleotides