In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles.
An in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 micrograms of CPA/ml of modified Krebs-Henseleit solution significantly (P less than 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA.
Miller
C D
CD
USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010.
Richard
J L
JL
Hembrough
F B
FB
Osweiler
G D
GD
Cox
D F
DF
D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D009126:Muscle Relaxation; D009132:Muscles / Q000187:drug effects*; D009183:Mycotoxins / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D013997:Time Factors; D014422:Turkeys
D007211:Indoles; D009183:Mycotoxins; C000543:cyclopiazonic acid