Human sperm chromosomes. Long-term effect of cancer treatment.
The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa.
Genescà
A
A
Departament de Biologia Cel.lular i Fisiologia, Universitat Autònoma de Barcelona, Spain.
Caballín
M R
MR
Miró
R
R
Benet
J
J
Bonfill
X
X
Egozcue
J
J
D000970:Antineoplastic Agents / Q000009:adverse effects; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011832:Radiation Injuries / Q000235:genetics; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D013997:Time Factors
D000970:Antineoplastic Agents