[Early diagnosis of late complications in juvenile diabetics].
In a group of 69 insulin dependent diabetics aged 19-59 years (mean 25.5 years) with a duration of diabetes of 2 to 34 years (mean 12.5) the authors assessed the incidence of diabetic retinopathy, nephropathy and neuropathy in relation to the duration of diabetes, to its long-term compensation and HLA antigens. In 45 the diabetes was manifested before the age of 15 years. The authors found a rising trend of retinopathy (12-14-25-75-86%) and neuropathy (0-50-60-85-83%) in five groups with a duration of diabetes up to 5, 10, 15, 20 and above 20 years. 15% of the patients with a duration of diabetes of more than 15 years had positive microalbuminuria or permanent proteinuria and hypertension. In diabetic patients with long-term satisfactory compensation there was a lower incidence of these complications than in patients with poorer compensation. The presence of HLA B8 antigen was associated with a prolonged favourable course of diabetes, with a lower incidence and later manifestation of complications.
Dvoráková
L
L
Interí klinika fakulty dĕtského lékarství, Univerzity Karlovy, Praha.
Boguszáková
J
J
Dubská
Z
Z
Englis
M
M
Sidlová
A
A
Májský
A
A
Mikan
M
M
Polácková
H
H
Platilová
H
H
Patejdlová
E
E
D000328:Adult; D003928:Diabetic Nephropathies / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
Casná diagnóza pozdních komplikací u mladistvých diabetiků.