Genetic evidence that the gene controlling Aub is located on chromosome 19.
DNA from a series of families segregating for Aub was analyzed with a genomic DNA probe which defines a Bg1 I polymorphism for apolipoprotein C II (APOC2). The investigation revealed that the gene for Aub is closely linked to APOC2 (z = 8.43 at theta = 0.00) for paternal and maternal meioses combined, to LW (z = 3.61 at theta = 0.00) in paternal meioses and less closely linked to SE (z = 3.10 at theta = 0.09) for combined paternal and maternal meioses. Therefore, we propose a chromosome 19 location for the Aub gene.
Zelinski
T
T
Department of Pediatrics, University of Manitoba, Canada.
Kaita
H
H
Johnson
K
K
Moulds
M
M
D001789:Blood Group Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D008040:Genetic Linkage; D006801:Humans
D001789:Blood Group Antigens