title: Epirubicin and ifosfamide in patients with refractory breast cancer and other metastatic solid tumours.
abstract: The combination of ifosfamide (IFO) and epirubicin (EPI) has been found to be an effective regimen in the treatment of metastatic tumours and shows remarkable activity in heavily pretreated breast cancer patients. A combination of EPI (35 mg/m2 on days 1 and 2) and IFO (1.8-2.5 g/m2 on days 1-5) was given to 58 patients with refractory breast cancer (n = 23), metastatic sarcomas (n = 15) and other solid tumours (n = 20). Due to extensive prior therapy, the IFO dose had to be adapted to the individual haematological situation. In all, 55 patients were evaluable; we observed 5 complete (CRs) and 16 partial responses (PRs). In addition, 18 patients experienced a minor response (MR) or no change (NC). The median duration of all responses was 6.7 months. Toxicity was generally mild and closely related to previous therapy.
authors.affiliation: Department of Oncology and Haematology, General Hospital of Leverkusen, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hoffmann
authors.forename: B
authors.initials: B
authors.lastname: Weidmann
authors.forename: F
authors.initials: F
authors.lastname: Migeod
authors.forename: J
authors.initials: J
authors.lastname: Könner
authors.forename: S
authors.initials: S
authors.lastname: Seeber
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004351:Drug Resistance; D015251:Epirubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage*; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000188:drug therapy
chemical_list: D015251:Epirubicin; D007069:Ifosfamide