Impaired antibody response of C57BL/6 beige mutant mice to a thymus-independent type 2 antigen.
The murine equivalent of the human Chediak-Higashi Syndrome is the beige (bg) mutant in the C57BL/6 (B6) background. Besides the well-known lack of natural killer (NK) activity in bg-homozygous mice, functional abnormalities of T cells, macrophages and various granulocytes have been reported. With the exception of one study indicating a decreased in vitro response to lipopolysaccharide, there is no report concerning the B cell compartment of the beige mutant. The in vivo anti-trinitrophenyl antibody response to a TI-2 antigen (TNP-Ficoll) was found here to be significantly lower in B6 beige than in B6 wild mice, although both strains responded similarly to an analogous TD antigen (TNP-ovalbumin). Since the marginal zone macrophages of the spleen were previously shown to be essential for the initiation of antibody responses to TI-2 antigens, they might be another target of the beige mutation.
Pflumio
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F
Laboratoire d'Immunologie, Université Louis Pasteur Strasbourg I, Illkirch, France.
Fonteneau
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P
Loor
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F
D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000473:pathology*; D000955:Antigens, T-Independent / Q000276:immunology*; D002609:Chediak-Higashi Syndrome; D004195:Disease Models, Animal; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008817:Mice, Mutant Strains / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
D000955:Antigens, T-Independent; C020529:TNP-ficoll; D014301:Trinitrobenzenes; C038600:trinitrophenyl-ovalbumin; D005362:Ficoll; D010047:Ovalbumin