Successful chemotherapy for newly diagnosed aggressive oligodendroglioma.
We treated 3 patients with newly diagnosed aggressive oligodendroglioma with chemotherapy prior to radiotherapy and observed responses. All had residual or progressive tumor following initial surgery. We used a combination called PCV-3 because recurrent anaplastic oligodendroglioma responds predictably to this regimen. Chemotherapy for response induction followed by radiotherapy for consolidation is feasible and effective initial treatment for this tumor.
Macdonald
D R
DR
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Gaspar
L E
LE
Cairncross
J G
JG
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008130:Lomustine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy; D011344:Procarbazine / Q000009:adverse effects / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use*
D011344:Procarbazine; D014750:Vincristine; D008130:Lomustine