title: Calcium, phosphorus and aluminium concentrations in the central nervous system, liver and kidney of rabbits with experimental atherosclerosis: preventive effects of vinpocetine on the deposition of these elements.
abstract: Calcium, phosphorus and aluminium concentrations in the central nervous system, liver and kidneys were determined in 16 rabbits with atherosclerosis experimentally induced by a cholesterol-rich diet and the protective effect of 3 or 10 mg/kg.day vinpocetine (14-ethoxycarbonyl-(3 alpha,16 alpha-ethyl)-14,15-eburnamenine) given orally on the deposition of these elements was assessed. Rabbits fed a cholesterol-rich diet developed atherosclerosis after 3 months and these rabbits possessed high concentrations of calcium, phosphorus and aluminium in the central nervous system, determined by neutron activation analysis. In atherosclerotic rabbits fed a vinpocetine supplement, there was a decrease in concentrations of these elements in tissues. It is suggested that calcium, phosphorus and aluminium may be implicated in the aetiology of atherosclerosis and that vinpocetine may have a preventive action on the deposition of these elements in central nervous tissue, liver and kidney.
authors.affiliation: Division of Neurological Diseases, Wakayama Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yasui
authors.forename: I
authors.initials: I
authors.lastname: Yano
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: A
authors.initials: A
authors.lastname: Oshima
mesh_terms: D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism*; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D008055:Lipids; D014748:Vinca Alkaloids; D010758:Phosphorus; C013983:vinpocetine; D000535:Aluminum; D002118:Calcium