title: Influence of clonidine, methyldopa and propranolol on acute toxicity of fenitrothion in mice.
abstract: The effect of pretreatment with clonidine, methyldopa and propranolol, and of atropine was studied in mice on acute toxicity of fenitrothion, the active ingredient of TIK-20. Atropine significantly decreased and propranolol somewhat decreased the fenitrothion induced death in mice. Clonidine and methyldopa somewhat increased the percentage mortality due to fenitrothion.
authors.affiliation: Department of Pharmacology, Maulana Azad Medical College, New Delhi.
authors.forename: N
authors.initials: N
authors.lastname: Valecha
authors.forename: S
authors.initials: S
authors.lastname: Prabhu
authors.forename: V L
authors.initials: VL
authors.lastname: Mehta
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D005278:Fenitrothion / Q000633:toxicity*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*
chemical_list: D008750:Methyldopa; D001285:Atropine; D011433:Propranolol; D003000:Clonidine; D005278:Fenitrothion