Effect of bismuth subcarbonate against Campylobacter pylori: do citrate ions improve antibacterial activity?
The minimum inhibitory concentrations of three bismuth subcarbonate preparations: 1. bismuth subcarbonate, 2. a mixture of 50% bismuth subcarbonate and 50% citric acid, 3. a mixture of 50% bismuth subcarbonate and 50% potassium citrate were assayed against 30 strains of Campylobacter pylori employing the agar dilution method. Bismuth subcarbonate alone exhibited an MIC50 of 2 mg/l and was more effective than the two combinations (MIC50 4 mg/l). It is concluded that the addition of citrate ions does not improve antibacterial activity.
Vogt
K
K
Institut für Medizinische Mikrobiologie, Freien Universität Berlin.
Warrelmann
M
M
Hahn
H
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001729:Bismuth / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002254:Carbonates; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D004338:Drug Combinations; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D012995:Solubility
D000900:Anti-Bacterial Agents; D002254:Carbonates; D002951:Citrates; D004338:Drug Combinations; D019343:Citric Acid; C028508:bismuth subcarbonate; D001729:Bismuth