title: [The effect of laser therapy on the mechanisms for generating healing in long-term nonhealing stomach ulcers].
abstract: A study was made of the effect of copper laser therapy on the content of PGE and PGF2 alpha and on the adenylate cyclase system (cAMP, cGMP and adenylate cyclase content) in patients with gastric ulcer. Seventy patients with indolent (from 3 months to 2 years) gastric ulcers were examined. The patients were assigned into 2 groups: group I received drug therapy combined with the influence of laser on copper vapours on the ulcerous surface (a single radiation dose 10 to 15 J). As compared to group I, the patients of group II manifested a considerable rise of the content of cAMP and prostaglandins, as well as adenylate cyclase activation in the gastric mucosa. Nonspecific biostimulating action of laser radiation exercised via the influence on the dysregenerative processes in the epitheliocytes of long nonhealing ulcer edges is under discussion.
authors.forename: A S
authors.initials: AS
authors.lastname: Loginov
authors.forename: G N
authors.initials: GN
authors.lastname: Sokolova
authors.forename: S V
authors.initials: SV
authors.lastname: Sokolova
authors.forename: E V
authors.initials: EV
authors.lastname: Tkachenko
authors.forename: E P
authors.initials: EP
authors.lastname: Markin
authors.forename: V R
authors.initials: VR
authors.lastname: Ambartsumian
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism / Q000528:radiation effects; D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D015237:Dinoprost / Q000378:metabolism / Q000528:radiation effects; D015232:Dinoprostone / Q000378:metabolism / Q000528:radiation effects; D004359:Drug Therapy, Combination; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005773:Gastroscopy; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects*
chemical_list: D015237:Dinoprost; D000262:Adenylyl Cyclases; D015232:Dinoprostone
vernacular_title: Vliianie lazeroterapii na nekotorye mekhanizmy sanogeneza dlitel'no nezazhivaiushchikh iazv zheludka.