title: Aversive taste stimuli increase CGRP levels in the gustatory insular cortex of the rat.
abstract: Calcitonin gene-related peptide-like immunoreactivity (CGRP-IR) was surveyed immunohistochemically in the insular cortex of the rat, and the levels of insular cortical CGRP-IR were measured with the radioimmunoassay method following intraoral stimulation with various taste stimuli. CGRP-IR was localized in nerve fibers within the agranular and dysgranular insular cortices. The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid. The results suggest that CGRP in the gustatory insular cortex is concerned with rejection or avoidance behaviors to aversive taste stimuli.
authors.affiliation: Department of Oral Physiology, Faculty of Dentistry, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: S
authors.initials: S
authors.lastname: Wakisaka
authors.forename: M
authors.initials: M
authors.lastname: Akai
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: N
authors.initials: N
authors.lastname: Yonehara
authors.forename: R
authors.initials: R
authors.lastname: Inoki
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D011803:Quinine; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*
chemical_list: D011803:Quinine; D015740:Calcitonin Gene-Related Peptide