title: The consumption of tobacco, alcohol and the risk of adenocarcinoma in Barrett's oesophagus.
abstract: The relationship between tobacco, alcohol and the risk of oesophageal adenocarcinoma in Barrett's oesophagus was evaluated in an endoscopy-clinic-based case-control study of 30 histologically confirmed cases of adenocarcinoma and 140 controls with Barrett's oesophagus but no evidence of malignant lesions. Among the cases, 18 (60%) were non-smokers and 14 (47%) non-drinkers, the corresponding proportions in the controls being 52% and 44%. Thus, there was no apparent relation between tobacco, alcohol and the risk of adenocarcinoma of the oesophagus, the age- and sex-adjusted point estimates being 1.0 for moderate and 0.9 for heavy smokers, 0.7 and 1.5 respectively for moderate and heavy drinkers. Upper 95% confidence limits were 1.6 for ever-use of tobacco and 1.9 for ever alcohol drinking. The findings of this study, although based on a limited number of cases, indicate that alcohol and tobacco are unlikely to play a major role in the aetiology of adenocarcinoma in Barrett's oesophagus.
authors.affiliation: Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, CHUV BH-06, Lausanne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Levi
authors.forename: J B
authors.initials: JB
authors.lastname: Ollyo
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
authors.forename: P
authors.initials: P
authors.lastname: Boyle
authors.forename: P
authors.initials: P
authors.lastname: Monnier
authors.forename: M
authors.initials: M
authors.lastname: Savary
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000434:Alcoholic Beverages / Q000009:adverse effects; D001471:Barrett Esophagus / Q000150:complications*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*