title: Calciphylaxis induced by iron-citrate sorbitol.
abstract: The author describes an experimental model of calciphylaxis induced by iron citrate sorbitol in young dogs. The lesions became apparent in form of nodular white and hard papules 0.1-0.5 cm in diameter 5-7 d after subcutaneous administration of iron. Microscopically a granulomatous reaction of the dermis and hypodermis are visible and also some associated modifications, as adipose cysts and fibrillar densification. From histochemical points of view a highly positive von Kossa reaction is observed on the adipocyte's membrane, on collagen fibers or as a compact extensive material. The significance of the morphohistochemical appearances is discussed as a dynamic process which leads to calciphylaxis of the skin and then to a granulomatous reaction of foreign body type. We suggest that this experimental model of calciphylaxis could serve as an explanation for some calcifications observed in human pathology.
authors.affiliation: Municipal Hospital of Arad, Department of Urology and Pathology, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Raica
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000139:chemically induced*; D002115:Calciphylaxis / Q000139:chemically induced*; D002951:Citrates; D019343:Citric Acid; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D005290:Ferric Compounds; D006651:Histocytochemistry; D008297:Male; D013012:Sorbitol
chemical_list: D002951:Citrates; D004338:Drug Combinations; D005290:Ferric Compounds; C008170:citric acid, iron, sorbitol drug combination; D019343:Citric Acid; D013012:Sorbitol