Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life.
In an unselected series of pediatric brain tumors, 56 of 60 long-term survivors--craniopharyngiomas and pituitary tumors excluded--were investigated and interviewed mean X = 10 (5-16) years after diagnosis. After this time, sequelae were stable and included cognitive (38%), motor (25%), visual (20%), hormonal (20%), and psychological-emotional (14%) dysfunction. Memory dysfunction was found in 22% of patients with normal intelligence. Moderate or severe disability, from combinations of these impairments, was found in 34%. Sixty-six percent had no or mild disability compatible with active life and employment. However, these patients less often were married or had children compared with a control group of healthy subjects. Moderate and severe disability was found in 48% of supra- and in 21% of infratentorial tumors, after radiotherapy (RT) in 55% vs. without RT in 18%. RT before 6 years of age caused subnormal IQ in all cases. The self-reported quality of life was not related to degree of disability. Patients with psychological-emotional sequelae self-evaluated their quality of life lower than did patients with other types of long-term sequelae.
Lannering
B
B
Department of Pediatrics I, University of Göteborg, Sweden.
Marky
I
I
Lundberg
A
A
Olsson
E
E
D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D004827:Epilepsy / Q000209:etiology; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology; D007361:Intelligence Tests; D008297:Male; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D012951:Socialization; D014786:Vision Disorders / Q000209:etiology