title: Intimal thickening and permeability of arterial autogenous vein graft in a canine poor-runoff model: transmission electron microscopic evidence.
abstract: The relationship between development of intimal thickening and permeability of an arterial autogenous vein grafts in dogs' limbs was examined with horseradish peroxidase used as a tracer. The transendothelial transports increased under conditions of abnormal blood flow, compared with findings with a normal blood flow, and a large amount of horseradish peroxidase infiltrated the subendothelial spaces for 4 weeks after implantation, a time when intimal thickening progressed rapidly. It would thus appear that, under conditions of abnormal blood flow, intimal hyperpermeation would be a contributing factor to the intimal thickening of an autogenous vein graft before an autovein graft had completely adapted to the new environment.
authors.affiliation: Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mii
authors.forename: K
authors.initials: K
authors.lastname: Okadome
authors.forename: T
authors.initials: T
authors.lastname: Onohara
authors.forename: S
authors.initials: S
authors.lastname: Yamamura
authors.forename: K
authors.initials: K
authors.lastname: Sugimachi
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002463:Cell Membrane Permeability; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D005268:Femoral Vein / Q000637:transplantation / Q000648:ultrastructure; D006735:Horseradish Peroxidase; D006965:Hyperplasia; D008297:Male; D008854:Microscopy, Electron; D014182:Transplantation, Autologous; D014680:Veins / Q000473:pathology / Q000637:transplantation* / Q000648:ultrastructure
chemical_list: D006735:Horseradish Peroxidase