Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats.
Isozyme patterns of S-adenosylmethionine synthetase have been measured with or without dimethylsulfoxide in liver of LEC rat hereditary hepatitis. The activities of the alpha- and beta-forms are decreased with age after birth, and decreased to a half level of 36 weeks after birth. Concentration of S-adenosylmethionine in the liver is almost a half level of control rat. However, the activity of glycine- and tRNA-methyltransferases in the liver shows no significant change.
Shimizu
K
K
Department of Pathological Biochemistry, Tokyo Medical and Dental University, Japan.
Abe
M
M
Yokoyama
S
S
Takahashi
H
H
Sawada
N
N
Mori
M
M
Tsukada
K
K
D000818:Animals; D050938:Glycine N-Methyltransferase; D006520:Hepatitis, Animal / Q000201:enzymology* / Q000235:genetics; D007527:Isoenzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology*; D008716:Methionine Adenosyltransferase / Q000032:analysis*; D008780:Methyltransferases / Q000032:analysis; D051381:Rats; D014166:Transferases / Q000032:analysis*; D012359:tRNA Methyltransferases / Q000032:analysis
D007527:Isoenzymes; D014166:Transferases; D008780:Methyltransferases; D012359:tRNA Methyltransferases; D050938:Glycine N-Methyltransferase; D008716:Methionine Adenosyltransferase