title: Radiation-induced squamous sialometaplasia.
abstract: We describe a patient with recurrent acantholytic squamous cell carcinoma following radiation therapy. Mohs micrographic sections revealed extensive squamous sialometaplasia showing striking histologic similarity to the patient's squamous cell carcinoma. Criteria necessary to differentiate squamous sialometaplasia from neoplasm are presented. This differentiation is important to ensure adequate tumor resection without unnecessary sacrifice of tumor-free tissue.
authors.affiliation: Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.
authors.forename: B
authors.initials: B
authors.lastname: Leshin
authors.forename: W L
authors.initials: WL
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: Koufman
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy; D002610:Cheek; D003937:Diagnosis, Differential; D005153:Facial Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008679:Metaplasia; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011832:Radiation Injuries / Q000175:diagnosis / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis; D012469:Salivary Glands / Q000473:pathology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000532:radiotherapy