Octreotide in the treatment of the dumping syndrome.
The effects of octreotide were investigated in 10 patients with dumping syndrome consequent on gastric surgery. A subcutaneous injection of 50 or 100 micrograms octreotide had a significant beneficial effect on certain objective measurements of dumping: packed cell volume, pulse, and blood pressure in patients with early dumping and blood glucose in those with late dumping. Symptoms were also remarkably reduced, as judged subjectively. Long-term self-administered octreotide, initially 50 micrograms b.i.d. and rising to 100 micrograms t.i.d. as necessary, in 5 patients caused improvement in symptoms in 2. In summary, octreotide has an objective effect on dumping and clinical studies suggest a role for octreotide in patients with severe symptoms.
Primrose
J N
JN
Department of Surgery, St James's University Hospital, Leeds, UK.
D000328:Adult; D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D004377:Dumping Syndrome / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*
D001786:Blood Glucose; D015282:Octreotide