Improved dissolution and absorption of drugs using low molecular gelatin.
Kneaded mixtures of a basic drug, meclizine dihydrochloride (MZ), and a neutral drug, prednisolone (PN), with low molecular gelatin at the weight ratio of 1:1 were prepared, and their in vitro dissolution and in vivo absorption behaviour were examined. The dissolution rate of drugs from the kneaded mixtures was significantly faster than that of the drugs themselves. The low molecular gelatin enhanced the dissolution rate of MZ and PN by improving the wettability of the drug particles without any interaction in solution and the solid state. After oral administration of the kneaded mixture to beagle dogs, the initial serum concentration was significantly higher than that of the drug alone. However, the AUC value of the drug from the kneaded mixture was almost same as that of drug alone.
Kimura
S
S
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Nishiyama
T
T
Imai
T
T
Otagiri
M
M
D005079:Excipients; D005780:Gelatin; D008468:Meclizine / Q000032:analysis; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000032:analysis; D011239:Prednisolone / Q000032:analysis; D012995:Solubility
D005079:Excipients; D004364:Pharmaceutical Preparations; D008468:Meclizine; D005780:Gelatin; D011239:Prednisolone