Effects of histamine on neurally mediated contraction of canine tracheal smooth muscle.
The neuromodulatory action of histamine was investigated in isolated canine trachea. Histamine potentiated the tracheal contraction induced by electrical field stimulation (EFS). The ACh release induced by EFS was potentiated by histamine. The potentiating effect was blocked by chlorpheniramine. These findings suggest that histamine potentiates the neurally mediated tracheal contraction and the potentiating effect may be related in part to the acceleration of the prejunctional release of ACh, which may be mediated by H1-receptors.
Tsuchiya
Y
Y
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Hosokawa
T
T
Kasuya
Y
Y
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
D006633:Histamine Antagonists; D002744:Chlorpheniramine; D006632:Histamine; D000109:Acetylcholine