[The effect of ascorbic acid administration on its levels in the brain tissue in intact and hypoxic 18-day-old rats].
A single dose of ascorbic acid, 1 mg/g of body weight by the i.p. route, caused a marked increase of its content in five areas of the brain in 18-day-old laboratory rats, as compared with intact animals. Acute hypoxia at 9000 m mitigated this increase. Conversely a combination of chronic intermittent hypoxia and ascorbic acid administration led in all investigated areas of the brain to a mild but insignificant rise of values except for the vermis cerebelli, where a significant rise at the 5% level of significance occurred.
Schreiber
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M
Fyziologický ústav fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Trojan
S
S
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001205:Ascorbic Acid
Vliv aplikace kyseliny askorbové na její obsah v mozkové tkáni intaktních a hypoxických 18 denních potkanů.