Intimal thickening and permeability of arterial autogenous vein graft in a canine poor-runoff model: transmission electron microscopic evidence.
The relationship between development of intimal thickening and permeability of an arterial autogenous vein grafts in dogs' limbs was examined with horseradish peroxidase used as a tracer. The transendothelial transports increased under conditions of abnormal blood flow, compared with findings with a normal blood flow, and a large amount of horseradish peroxidase infiltrated the subendothelial spaces for 4 weeks after implantation, a time when intimal thickening progressed rapidly. It would thus appear that, under conditions of abnormal blood flow, intimal hyperpermeation would be a contributing factor to the intimal thickening of an autogenous vein graft before an autovein graft had completely adapted to the new environment.
Mii
S
S
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okadome
K
K
Onohara
T
T
Yamamura
S
S
Sugimachi
K
K
D000818:Animals; D001783:Blood Flow Velocity; D002463:Cell Membrane Permeability; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D005268:Femoral Vein / Q000637:transplantation / Q000648:ultrastructure; D006735:Horseradish Peroxidase; D006965:Hyperplasia; D008297:Male; D008854:Microscopy, Electron; D014182:Transplantation, Autologous; D014680:Veins / Q000473:pathology / Q000637:transplantation* / Q000648:ultrastructure
D006735:Horseradish Peroxidase