Haematological changes after renal transplantation: differences between cyclosporin-A and azathioprine therapy.
Haematological changes after renal transplantation in 76 patients were reviewed and the differences observed between patients treated with cyclosporin-A and prednisolone and those treated with azathioprine and prednisolone were compared. Erythrocytosis defined as haemoglobin concentration equal to or exceeding 17 g/dl occurred in 25% of patients treated with cyclosporin-A and in 11.4% of patients treated with azathioprine. Only one patient, who received cyclosporin-A, had clinical evidence of thrombosis. Eight patients treated with cyclosporin-A and five treated with azathioprine had therapeutic venesections. There was no difference in the incidence of putative risk factors for post-transplant erythrocytosis between the two groups.
Fang
G X
GX
Department of Medicine, University of Hong Kong.
Chan
P C
PC
Cheng
I K
IK
Li
M K
MK
Wong
K K
KK
Chan
M K
MK
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D001769:Blood / Q000187:drug effects*; D002648:Child; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000627:therapeutic use*; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects
D003524:Cyclosporins; D006454:Hemoglobins; D003404:Creatinine; D001379:Azathioprine