Effect of reserpine on retention of the conditioned NK cell response.
The effect of reserpine and 6-hydroxydopamine on the learned conditioned natural killer (NK) cell response was investigated in mice. Reserpine given at 2.5 mg/kg, 24 hr prior to reexposure to camphor-conditioned stimulus on days 6 and 8 blocked the recall of conditioned NK cell response to a significant extent. In other words, the NK cell activity of conditioned mice, treated with reserpine and reexposed to the conditioned stimulus, was similar to the nonconditioned (NC) group. A conditioned increase in NK cell response was still evident in mice treated with 6-OHDA.
Hiramoto
R
R
Department of Microbiology, University of Alabama, Birmingham 35294.
Solvason
B
B
Ghanta
V
V
Lorden
J
J
Hiramoto
N
N
D000818:Animals; D002164:Camphor; D003214:Conditioning, Classical; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D012110:Reserpine / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects*; D013563:Sympathectomy, Chemical
D002164:Camphor; D012110:Reserpine