title: A simplified normalized ejection phase index measured by Doppler echocardiography for the assessment of left ventricular performance.
abstract: Although useful for the assessment of directional changes in contractility in individual patients, resting peak aortic blood velocity is of limited value for differentiating among patients with different levels of basal cardiac function. A dimensional analysis based on fluid dynamics shows that peak aortic blood velocity is not only generated by the contracting myocardium but also reflects the convective acceleration of blood from the left ventricle to the aorta. The reduction of cross-sectional area from the midleft ventricle to the aorta at the time of peak aortic blood velocity generates the convective acceleration. Accordingly, a higher convective acceleration due to left ventricular (LV) enlargement as observed in cardiomyopathy may explain why peak aortic blood velocity can be maintained as normal although myocardial contractility is depressed. This study tested the hypothesis that peak aortic blood velocity normalized by the ratio of midleft ventricle to aortic cross-sectional areas might provide a reliable index of LV performance. Nine normal control subjects and 25 patients undergoing catheterization were studied by M-mode, 2-dimensional and Doppler echocardiography. The normalized peak velocity measured noninvasively showed a high correlation with angiographic ejection fraction (r = 0.90, p less than 0.0001). Peak aortic blood velocity and the ratio of midleft ventricle to aortic cross-sectional areas alone correlated less well with ejection fraction (r = 0.76 and r = 0.75, p less than 0.0001, respectively). Furthermore, peak aortic blood velocity showed a significant overlap between patients with normal and those with abnormal LV function, whereas normalized peak aortic blood velocity was a better discriminator.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, University of Nancy, France.
authors.forename: K
authors.initials: K
authors.lastname: Isaaz
authors.forename: G
authors.initials: G
authors.lastname: Ethevenot
authors.forename: P
authors.initials: P
authors.lastname: Admant
authors.forename: B
authors.initials: B
authors.lastname: Brembilla
authors.forename: C
authors.initials: C
authors.lastname: Pernot
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000502:physiology / Q000503:physiopathology; D001783:Blood Flow Velocity; D017023:Coronary Angiography; D015150:Echocardiography, Doppler; D005260:Female; D006334:Heart Function Tests / Q000379:methods; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D016276:Ventricular Function