title: [Extrapyramidal syndromes caused by flunarizine. Apropos of 6 cases].
abstract: The ability of flunarizine in inducing or worsening extrapyramidal symptoms is well documented. The relation with age or dose of such symptoms as their clinical characteristics remain controversial. We report 6 cases of extrapyramidal syndromes induced by flunarizine in five women and one man (mean age 71.5 +/- 5 years). The daily dose was 10 mg in five cases (as recommended by the marketing laboratory) and 20 mg in one patient. These observations allow to discuss the dose-dependent occurrence of this adverse reaction. In only three cases the reason for treatment was compatible with the official french indication. These side effects appeared after 7.0 +/- 1.6 months and disappeared after 2.2 +/- 0.5 months respectively. Flunarizine-induced extrapyramidal symptoms are mainly characterized by tremor (which was the main symptom in 4 cases and the only one in 2 cases).
authors.affiliation: Service de Pharmacologie Médicale et Clinique, INSERM U317, Centre Hospitalier Universitaire, Faculté de Médecine, Toulouse.
authors.forename: J M
authors.initials: JM
authors.lastname: Senard
authors.forename: M
authors.initials: M
authors.lastname: Colomes
authors.forename: M
authors.initials: M
authors.lastname: Rostin
authors.forename: M
authors.initials: M
authors.lastname: Clanet
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D005260:Female; D005444:Flunarizine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005444:Flunarizine
vernacular_title: Syndromes extrapyramidaux induits par la flunarizine. A propos de 6 observations.