title: [The subclinical portion in the periphery of lentigo maligna and lentigo maligna melanoma].
abstract: Lentigo maligna is a precancerosis or a melanoma in situ, whose level of malignancy has not yet been definitively clarified. Recurrences are not rare after excision, even when an ample safe margin is observed. One reason for this is the existence of a subclinical ramification in the marginal area of the lentigo maligna. Such subclinical ramifications were investigated by means of excision with histological monitoring of the margins by the paraffin section technique. There was a clear relationship between the frequency of these ramifications and the clinical safe margin left in 64 excisions. With the aid of parametric evaluation methods the distribution of the subclinical portion referred to the distance from the clinical margin could be determined with a special formula. If an invasion, in the form of a lentigo maligna melanoma had already taken place, then the subclinical portion within the marginal area was significantly more extensive. For the treatment of lentigo maligna, and especially of lentigo maligna melanoma, we therefore recommend excision with histological monitoring of the margins. There were no local recurrences within an average follow-up period of about 2 1/2 years.
authors.affiliation: Abteilung Dermatologie I, Universitäts-Hautklinik Tübingen.
authors.forename: C
authors.initials: C
authors.lastname: Michaelsen
authors.forename: H
authors.initials: H
authors.lastname: Breuninger
authors.forename: G
authors.initials: G
authors.lastname: Rassner
authors.forename: K
authors.initials: K
authors.lastname: Dietz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007911:Lentigo / Q000473:pathology / Q000601:surgery*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*
vernacular_title: Der subklinische Anteil im Randbereich der Lentigo maligna und des Lentigo-maligna-Melanoms.