Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum.
This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer matrix pellet into the denervated striatum of rats. Animals that received DA-releasing pellets showed a 50% reduction in apomorphine-induced rotational behavior, and this effect persisted for the 2-month duration of the experiment. The results suggest that the controlled release of DA from an intrastriatal polymer matrix can produce a long-lasting reduction in some of the symptoms associated with DA depletion.
Becker
J B
JB
Department of Psychology, University of Michigan, Ann Arbor.
Robinson
T E
TE
Barton
P
P
Sintov
A
A
Siden
R
R
Levy
R J
RJ
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000008:administration & dosage / Q000502:physiology*; D004343:Drug Implants; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000378:metabolism / Q000502:physiology*
D004343:Drug Implants; D004298:Dopamine