Hemodialysis clearance of intravenously administered ribavirin.
A patient with an implanted artificial heart, acute, anuric renal failure, and disseminated influenza virus type A infection received intravenous ribavirin. Drug elimination by hemodialysis was measured. Plasma dialysis clearance averaged 93.9 +/- 8.6 ml/min. The maximum amount of ribavirin removed from the body during one period of hemodialysis was 79.1 mg. Ribavirin is not removed in important quantities by hemodialysis.
Kramer
T H
TH
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.
Gaar
G G
GG
Ray
C G
CG
Minnich
L
L
Copeland
J G
JG
Connor
J D
JD
D000328:Adult; D005260:Female; D006354:Heart, Artificial; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000188:drug therapy; D007275:Injections, Intravenous; D006435:Renal Dialysis; D012254:Ribavirin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012263:Ribonucleosides / Q000493:pharmacokinetics*
D012263:Ribonucleosides; D012254:Ribavirin