title: [Anti-inflammatory and analgesic activity of etofenamate after intramuscular injection in laboratory animals].
abstract: Antiphlogistic and Analgetic Activity of Etofenamate in Laboratory Animals after Intramuscular Administration by injection of an oily solution of 10.5; 15; 19.5 mg etofenamate/kg body weight it was possible to inhibit the development of the carrageenan edema in the rat paw. Even four days after the single i.m. injection of etofenamate (active substance of Rheumon i.m.) the swelling of the rat paw is effectively prevented. By the Randall-Selitto-analgesia test it was possible to demonstrate the fast onset. Already 1 h after the injection of 15 mg/kg the pain threshold is increased to about 60%. Even in this testsystem the prolonged efficacy of oil diluted etofenamate can be found.
authors.affiliation: Antiphlogistika-Forschung, Troponwerke GmbH & Co. KG, Köln.
authors.forename: B
authors.initials: B
authors.lastname: Pelster
authors.forename: H D
authors.initials: HD
authors.lastname: Dell
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005439:Flufenamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006207:Half-Life; D007273:Injections, Intramuscular; D008657:Metabolic Clearance Rate; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005439:Flufenamic Acid; C015207:etofenamate
vernacular_title: Antiphlogistische und analgetische Wirkung von Etofenamat nach intramuskulärer Applikation bei Versuchstieren.