Rapidly adapting receptors monitor lung compliance in spontaneously breathing dogs.
We examined the ability of rapidly adapting receptors (RARs) to monitor changes in dynamic lung compliance (Cdyn) in anesthetized spontaneously breathing dogs by recording RAR impulses from the vagus nerves. We decreased Cdyn in steps through the physiological range by briefly restricting lung expansion with an inflatable cuff around the chest and recording the response after deflating the cuff; we restored Cdyn to control by hyperinflating the lungs. Of 45 RARs, 34 were stimulated by a 40 +/- 2% reduction in Cdyn, their inspiratory discharge increasing on average more than threefold. Two-thirds of responsive RARs were stimulated by less than or equal to 20% reductions in Cdyn; in most, firing increased proportionately with lung stiffness (1/Cdyn) as Cdyn was decreased further. Stimulation by reduced Cdyn was not simply a function of the concomitant increase in transpulmonary pressure, because similar increases in pressure produced by increasing tidal volume produced smaller increases in firing. RAR stimulation was unaffected by atropine and, hence, was not dependent on neurally mediated changes in bronchomotor tone. Our results indicate that during spontaneous breathing RARs provide a signal inversely proportional to Cdyn.
Pisarri
T E
TE
Cardiovascular Research Institute, University of California, San Francisco 94143-0130.
Jonzon
A
A
Coleridge
J C
JC
Coleridge
H M
HM
D000222:Adaptation, Physiological; D000818:Animals; D004285:Dogs; D004594:Electrophysiology; D008170:Lung Compliance / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D011661:Pulmonary Stretch Receptors / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013909:Thorax / Q000033:anatomy & histology / Q000502:physiology; D013990:Tidal Volume