[Effects of alpha tocopherol and free fatty acids on physical properties of lipid matrix and adenylate cyclase activity in rat brain synaptosomes].
Using modification of physical state of synaptosome lipid matrix by free fatty acids and alpha-tocopherol it was shown that fluidity of lipid matrix isn't limiting regulating factor for the activity of alpha-adrenergic aden late cyclase. From the point of view that state of annular lipids is different from the state of lipid bilayer in synaptosomes we suggest that composition of annular lipids regulates alpha-adrenergic adenylate cyclase system in rat neuronal membranes.
Gorbunov
N V
NV
Kuznetsova
L A
LA
Brusovanik
V I
VI
Erin
A N
AN
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D014810:Vitamin E / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014810:Vitamin E; D000262:Adenylyl Cyclases
Deĭstvie alfa-tokoferola i svobodnykh zhirnykh kislot na fizicheskie svoĭstva lipidnogo matriksa i aktivnost' adenilattsiklazy sinaptosomommozga krys.