title: Relationship of thyroid disease to renal cell carcinoma. An epidemiologic study.
abstract: Thyroid hormone participates in numerous cellular functions besides thermogenesis and metabolism. Several studies, including the recent identification of the product of an oncogene, c-erb-A, as a thyroid-hormone receptor, have shown possible involvement of thyroid hormone in the process of carcinogenesis. A recent anecdotal observation of an unusually high incidence of thyroid dysfunction in women with renal cell carcinoma led to a retrospective review of the incidence and distribution of thyroid disorders in women with renal cell carcinoma compared with a control group of women with transitional cell carcinoma of the renal pelvis, ureter, bladder, or urethra. Women with renal cell carcinoma had a statistically significantly higher percentage of hypothyroidism, thyroid disease in general, and the use of thyroid-hormone supplements as compared with the control group (P = 0.033, P = 0.005, P = 0.041, respectively). The nature of the relationship, however, could not be determined. These findings add a new dimension to renal cell carcinoma, and prospective studies are encouraged to define the contribution of thyroid hormone to renal cell carcinogenesis.
authors.affiliation: Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: A G
authors.initials: AG
authors.lastname: Rosenberg
authors.forename: F
authors.initials: F
authors.lastname: Dexeus
authors.forename: D A
authors.initials: DA
authors.lastname: Swanson
authors.forename: A C
authors.initials: AC
authors.lastname: von Eschenbach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications*; D002295:Carcinoma, Transitional Cell / Q000150:complications; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D013959:Thyroid Diseases / Q000150:complications* / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000150:complications