title: Effects of orchiectomy and polyestradiol phosphate therapy on serum lipoprotein lipids and glucose tolerance in prostatic cancer patients.
abstract: In 17 prostatic cancer patients, changes in the plasma lipoprotein pattern, including high density lipoprotein (HDL) subfractions, and in glucose tolerance were compared after 6 months on parenteral polyestradiol phosphate (PEP; Estradurin, 80 or 160 mg/month) with the respective changes in orchiectomized patients. In the estrogen group there was no change in the total serum cholesterol level, whereas in the orchiectomy group an increase of 10% was observed. Estrogen therapy resulted in a significant increase of serum HDL (11%) and HDL2 cholesterol (26%) levels; in the orchiectomy group these fractions remained unchanged. Estrogen therapy induced a significant decrease in total serum triglycerides (24%) and in low density lipoprotein triglycerides (27%); in the orchiectomy group reverse changes were observed. PEP treatment caused changes in the serum lipoprotein pattern, which apparently decreases the risk of atherosclerosis.
authors.affiliation: Second Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Aro
authors.forename: R
authors.initials: R
authors.lastname: Haapiainen
authors.forename: T
authors.initials: T
authors.lastname: Sane
authors.forename: S
authors.initials: S
authors.lastname: Rannikko
authors.forename: R
authors.initials: R
authors.lastname: Pelkonen
authors.forename: O
authors.initials: O
authors.lastname: Alfthan
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000627:therapeutic use*; D005951:Glucose Tolerance Test; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D045166:Estradiol Congeners; D008074:Lipoproteins; D013739:Testosterone; D004958:Estradiol; D002784:Cholesterol; C008958:polyestradiol phosphate