[The induction of an acquired storage pool deficiency of the thrombocytes by IgG antibodies in systemic lupus erythematosus and chronic polyarthritis].
Sera of patients with RA and SLE contain platelet-reactive IgG antibodies, which bring about the release of serotonin from platelets. They can also induce the aggregation of normal human platelets. In addition, such antibodies cause a decreased in vitro disaggregation of platelets after ADP exposure, as well as a significantly reduced collagen-induced aggregation. Thus, IgG platelet antibodies in RA and SLE can cause a functional impairment of patients' platelets, and may also be instrumental in systemic inflammatory rheumatoid disease by releasing proinflammatory mediators.
Falke
S
S
Zentrum für Innere Medizin und Dermatologie, Medizinische Hochschule Hannover.
Avenarius
H J
HJ
Deicher
H
H
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001168:Arthritis / Q000150:complications* / Q000276:immunology; D001791:Blood Platelet Disorders / Q000209:etiology*; D001792:Blood Platelets / Q000276:immunology; D002908:Chronic Disease; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D010974:Platelet Aggregation / Q000187:drug effects / Q000276:immunology; D010981:Platelet Storage Pool Deficiency / Q000209:etiology* / Q000276:immunology; D012698:Serologic Tests / Q000379:methods; D012701:Serotonin / Q000097:blood
D007074:Immunoglobulin G; D012701:Serotonin; D000244:Adenosine Diphosphate; D003094:Collagen
Induktion einer 'acquired storage pool deficiency' der Thrombozyten durch IgG-Autoantikörper bei systemischem Lupus erythematodes und chronischer Polyarthritis.