title: Trace element nutrition status and dietary intake of children with phenylketonuria.
abstract: The trace element status (copper, iron, zinc, manganese, chromium, and selenium) of 20 dietetically treated phenylketonuric (PKU) children was assessed. Significantly higher intakes of copper (p = 0.002) and iron (p = 0.005) were noted in PKU children compared with their siblings. No significant differences were found for zinc, manganese, or chromium. Intake of selenium was significantly lower (p = 0.0001) in PKU children (8.4 +/- 3.9 micrograms/d) than in siblings (41.6 +/- 9.4 micrograms/d). Plasma and urine selenium and erythrocyte glutathione peroxidase activity (GSHpx) were significantly lower (p = 0.001) in PKU children (0.38 +/- 0.11 mumol/L, 58.0 +/- 34.5 nmol/d, and 14.2 +/- 5.5 U/g Hb, respectively) than in siblings (0.82 +/- 0.15 mumol/L, 165.2 +/- 49.4 nmol/d, and 22.7 +/- 5.2 U/g Hb, respectively). No differences were found in plasma and urine concentrations of other elements. Intake of selenium was significantly correlated with erythrocyte GSHpx (r = 0.87, p = 0.0001) and plasma selenium (r = 0.71, p = 0.0001) for the combined groups. The need and possible procedures, including dietary manipulation, for increasing selenium intake in PKU subjects are discussed.
authors.affiliation: Department of Public Health and Nutrition, Queensland University of Technology, Brisbane, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Reilly
authors.forename: J E
authors.initials: JE
authors.lastname: Barrett
authors.forename: C M
authors.initials: CM
authors.lastname: Patterson
authors.forename: U
authors.initials: U
authors.lastname: Tinggi
authors.forename: S L
authors.initials: SL
authors.lastname: Latham
authors.forename: A
authors.initials: A
authors.lastname: Marrinan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004032:Diet; D004912:Erythrocytes / Q000032:analysis / Q000201:enzymology; D005260:Female; D005504:Food Analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D010661:Phenylketonurias / Q000178:diet therapy*; D012643:Selenium / Q000097:blood / Q000652:urine; D014131:Trace Elements / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D014131:Trace Elements; D005979:Glutathione Peroxidase; D012643:Selenium