title: Mechanism of spontaneous, concentration-dependent phospholipid transfer between bilayers.
abstract: We have previously demonstrated that spontaneous phospholipid transfer between bilayer vesicles at higher vesicle concentrations is characterized not only by a first-order desorption rate but also by a second-order process dependent on vesicle concentration (Jones & Thompson, 1989b). We have extended our studies to examine the mechanism of this second-order process by investigating transfer as a function of lipid type, temperature, aqueous medium composition, and vesicle size. The results suggest a mechanism of concentration-dependent transfer in which the rate of lipid monomer desorption from vesicle bilayers is enhanced in transient vesicle-vesicle complexes.
authors.affiliation: Department of Biochemistry, University of Virginia, Charlottesville 22908.
authors.forename: J D
authors.initials: JD
authors.lastname: Jones
authors.forename: T E
authors.initials: TE
authors.lastname: Thompson
mesh_terms: D002784:Cholesterol; D007700:Kinetics; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011189:Potassium Chloride; D013696:Temperature
chemical_list: D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011189:Potassium Chloride; D002784:Cholesterol; C028694:1-palmitoyl-2-oleoylphosphatidylcholine