title: [Possibility of the development of non-transfusion hemosiderosis in beta-thalassemia, caused by association with HLA-linked hemochromatosis].
abstract: The data of HLA-haplotyping were used as an allele marker controlling hereditary hemochromatosis in 23 patients with beta-thalassemia. The results obtained have permitted a conclusion that hemosiderosis in patients with beta-thalassemia may be caused by association of beta-thalassemia gene with hereditary hemochromatosis. Early diagnosis of hyperferremia is of great prognostic importance as the adequate treatment timely conducted can prevent the development of irreversible changes in the patients.
authors.forename: D A
authors.initials: DA
authors.lastname: Settarova
authors.forename: S I
authors.initials: SI
authors.lastname: Donskov
authors.forename: R P
authors.initials: RP
authors.lastname: Manishkina
authors.forename: T K
authors.initials: TK
authors.lastname: Krasavtseva
authors.forename: E G
authors.initials: EG
authors.lastname: Klinika
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015791:HLA-A3 Antigen / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen / Q000235:genetics; D015793:HLA-B7 Antigen / Q000235:genetics; D006432:Hemochromatosis / Q000150:complications* / Q000235:genetics; D006486:Hemosiderosis / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013789:Thalassemia / Q000150:complications* / Q000235:genetics
chemical_list: D006680:HLA Antigens; D015791:HLA-A3 Antigen; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen; D015793:HLA-B7 Antigen
vernacular_title: Vozmozhnost' netransfuzionnogo gemosideroza pri beta-thalassemii, obuslovlennogo assotsiatsieĭ s gemokhromatozom, stseplennym s HLA.