title: Immunoreactive interleukin-1 beta localization in the rat forebrain.
abstract: To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.
authors.affiliation: Department of Medicine, New England Medical Center, Boston, MA 02111.
authors.forename: R M
authors.initials: RM
authors.lastname: Lechan
authors.forename: R
authors.initials: R
authors.lastname: Toni
authors.forename: B D
authors.initials: BD
authors.lastname: Clark
authors.forename: J G
authors.initials: JG
authors.lastname: Cannon
authors.forename: A R
authors.initials: AR
authors.lastname: Shaw
authors.forename: C A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: S
authors.initials: S
authors.lastname: Reichlin
mesh_terms: D000818:Animals; D005625:Frontal Lobe / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000378:metabolism*; D011817:Rabbits
chemical_list: D007375:Interleukin-1