Antiplaque activity of some antimicrobial agents using a simple in vitro method.
Some antimicrobial compounds were tested for their antiplaque activity by a simple method involving measurement of the weight of Streptococcus sobrinus plaque on a glass surface. Chlorhexidine, cetylpyridinium chloride, and n-tetradecylamine reduced the weight of plaque produced by S. sobrinus in vitro; some N-palmityl and palmitoyl derivatives of polymethylenediamines were also found to possess antiplaque activity. The results suggest that an antiplaque effect does not necessarily depend on high bactericidal activity.
Murata
Y
Y
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Miyamoto
E
E
Ueda
M
M
D000588:Amines / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D001558:Benzethonium / Q000494:pharmacology; D002594:Cetylpyridinium / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology*; D003959:Diamines / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D006801:Humans; D006838:Hydrocarbons; D013291:Streptococcus / Q000187:drug effects*
D000588:Amines; D000900:Anti-Bacterial Agents; D001548:Benzalkonium Compounds; D003959:Diamines; D004202:Disinfectants; D006838:Hydrocarbons; D001558:Benzethonium; D002594:Cetylpyridinium; C020514:N-tetradecylamine; C013553:hexadecylamine; D002710:Chlorhexidine