title: Primary malignant melanoma of the vagina: a clinicopathological analysis of 10 cases.
abstract: We retrospectively analyzed clinicopathological findings in 10 cases of primary malignant melanoma of the vagina. The main presenting symptoms were vaginal bleeding, vaginal discharge, and feeling of a mass. The tumors were predominantly located in the lowest one-third and in the anterolateral aspect of the vagina. Patients underwent various surgical procedures, radiation therapy, and chemotherapeutic modalities. The mean survival time and the recurrence time from the time of diagnosis were 15 and 8 months, respectively. The tumors were examined for histological characteristics of cell type, presence of melanin pigment, depth of invasion, vascular invasion, intraepithelial spread, junctional activity, and mitotic count. Of all these histological variables, the mean survival time had a significant correlation to mitotic count (P less than 0.04). We concluded that patients with lower mitotic counts (less than 6 per 10 HPF) had better survival (21 months) compared to patients with mitotic counts greater than 6 per 10 HPF who had a mean survival of only 7 months.
authors.affiliation: Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis 55455.
authors.forename: G
authors.initials: G
authors.lastname: Borazjani
authors.forename: K A
authors.initials: KA
authors.lastname: Prem
authors.forename: T
authors.initials: T
authors.lastname: Okagaki
authors.forename: L B
authors.initials: LB
authors.lastname: Twiggs
authors.forename: L L
authors.initials: LL
authors.lastname: Adcock
mesh_terms: D005260:Female; D006801:Humans; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008940:Mitotic Index; D009364:Neoplasm Recurrence, Local; D013534:Survival; D013997:Time Factors; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery