title: Increased serum kininase I activity in pregnancy complicated by pre-eclampsia.
abstract: Serum kininase I activity was measured in normal pregnancy and pre-eclampsia. The mean value in nonpregnant controls was 180 +/- 25 (SD) nmol/min/ml. Kininase I activity during normal pregnancy significantly increased after week 14, reaching the highest value (240 +/- 20 nmol/min/ml) at weeks 38 and 40. The kininase I activity in pregnancy complicated by severe pre-eclampsia was higher than that in normal pregnancy. The possible role played by elevated kininase I levels in pre-eclampsia was discussed.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Mizutani
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: O
authors.initials: O
authors.lastname: Kurauchi
authors.forename: M
authors.initials: M
authors.lastname: Kasugai
authors.forename: O
authors.initials: O
authors.lastname: Narita
authors.forename: Y
authors.initials: Y
authors.lastname: Tomoda
mesh_terms: D000328:Adult; D002268:Carboxypeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D001121:Lysine Carboxypeptidase / Q000097:blood*; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy
chemical_list: D002268:Carboxypeptidases; D001121:Lysine Carboxypeptidase