[Different rates of theophylline clearance. A statistical study of a group of asthmatics].
In standard clinical practice the pharmacokinetic profile of theophylline is monitored by measuring blood levels of the drug. However a more accurate picture of the metabolic pattern over time can be obtained by monitoring theophylline clearance. This technique was applied to 40 lung disease patients most (55%) of them slow metabolisers as described in the literature. In the light of this findings, cautious dosing is advisable when no data are available or clearance (difficult to apply outside a strictly specialist environment).
Gai
R
R
Ospedale Pneumologico S Luigi Gonzaga, Orbassano, Torino.
Oliaro
A
A
Galietti
F
F
Giorgis
G E
GE
Bruna
S
S
Ardizzi
A
A
Bianchi
M
M
Bernardi
W
W
D001249:Asthma / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011863:Radioimmunoassay; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D013806:Theophylline
Studio delle diverse velocità di clearance della teofillina. Studio statistico su un gruppo di asmatici.