Early determination in the C. elegans embryo: a gene, cib-1, required to specify a set of stem-cell-like blastomeres.
The early somatic blastomeres founding the tissues in the C. elegans embryo are derived in a stem-cell-like lineage from the P cells. We have isolated maternal effect lethal mutations defining the gene cib-1 in which the P cells, P1-P3, skip a cell cycle and acquire the fates of only their somatic daughters. Therefore, the cib-1 gene is required for the specification of the stem-cell-like fate of these cells. The analysis of the development of these mutants suggests that the clock controlling the cell cycles in the early embryo is directly coupled to the fate of a cell and that there must be another developmental clock that activates the determinative inventory for the early decision-making.
Schnabel
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Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Schnabel
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D000483:Alleles; D000818:Animals; D001757:Blastomeres / Q000502:physiology* / Q000648:ultrastructure; D002107:Caenorhabditis / Q000235:genetics*; D002453:Cell Cycle; D005796:Genes / Q000235:genetics*; D005804:Genes, Lethal / Q000502:physiology; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009154:Mutation