[Modification of catecholamine metabolism in rats by magnesium aspartate hydrochloride].
The metabolism of catecholamines was studied in rats treated with magnesium aspartate hydrochloride (MAH). For 3 days, MAH was administered via food (1000 mg magnesium/kg food). An enhanced renal elimination of catecholamine metabolites was found in MAH-treated rats as well as in rats stressed by immobilisation. Measured in vitro, hepatic monoaminoxidase activity was enhanced. The catechol-O-methyltransferase activity was not altered. In conclusion, oral treatment with MAH is followed by enhanced hepatic metabolism and increased renal elimination of catecholamines.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztlichen Hochschule, Hannover.
Kreisner
M
M
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D007103:Immobilization; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism / Q000662:veterinary*
D002395:Catecholamines; D001224:Aspartic Acid; D008995:Monoamine Oxidase
Beeinflussung der Katecholamin-Metabolisierung bei Ratten durch Magnesiumaspartat-Hydrochlorid.