title: Rapid periarticular bone loss in rheumatoid arthritis. Possible promotion by normal circulating concentrations of parathyroid hormone or calcitriol (1,25-dihydroxyvitamin D3).
abstract: For approximately 2 years, bone loss was measured in women with early stages of rheumatoid arthritis (RA) and in control subjects, using serial computed tomography and dual photon absorptiometry. Rapid trabecular bone loss from the distal radius was observed in the RA patients but not the controls. The bone loss correlated with initial plasma levels of parathyroid hormone and 1,25-dihydroxyvitamin D3 (calcitriol) concentrations. It has been suggested that these humoral factors may interact with cytokines or other mediators produced in the adjacent wrist joint. Losses of the cortical bone of the radial midshaft and the lumbar spine were modest and were comparable in the 2 groups. Indices relating to both bone formation and bone resorption predicted bone loss at these 2 sites, but changes in the parathyroid hormone and calcitriol concentrations did not.
authors.affiliation: Northwick Park Hospital, Harrow, Middlesex, United Kingdom.
authors.forename: P N
authors.initials: PN
authors.lastname: Sambrook
authors.forename: D
authors.initials: D
authors.lastname: Shawe
authors.forename: R
authors.initials: R
authors.lastname: Hesp
authors.forename: J M
authors.initials: JM
authors.lastname: Zanelli
authors.forename: R
authors.initials: R
authors.lastname: Mitchell
authors.forename: D
authors.initials: D
authors.lastname: Katz
authors.forename: J M
authors.initials: JM
authors.lastname: Gumpel
authors.forename: B M
authors.initials: BM
authors.lastname: Ansell
authors.forename: J
authors.initials: J
authors.lastname: Reeve
mesh_terms: D015502:Absorptiometry, Photon; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000000981:diagnostic imaging; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D002117:Calcitriol / Q000097:blood; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D010281:Parathyroid Hormone / Q000097:blood; D011884:Radius / Q000378:metabolism; D013131:Spine / Q000000981:diagnostic imaging / Q000378:metabolism; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D010281:Parathyroid Hormone; D002117:Calcitriol