Relationship between fatty acid synthesis, transport and total lipid content during human fetal lung development.
Levels of fatty acid binding proteins (FABPs), lipids as well as activities of fatty acid synthesizing enzymes such as fatty acid synthase and ATP-citrate lyase increase with gestation showing maximum at term in human fetal lung. However, the activity of ATP-citrate lyase showed the same trend up to 30 weeks of gestation before declining slightly at term. These results indicate the importance of supply and/or synthesis of fatty acids when lung surfactant synthesis begins; thereby showing a correlation between the FABPs, lipid pattern and the activities of fatty acid synthesizing enzymes during prenatal lung development.
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Department of Biochemistry, University of Calcutta, College of Science.
Das
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Mukherjea
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D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D064429:Fatty Acid Synthases / Q000378:metabolism; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000201:enzymology* / Q000378:metabolism; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D064429:Fatty Acid Synthases; D001275:ATP Citrate (pro-S)-Lyase