Experimental studies on the late effects of female sex hormones.
Inj. Hydroxyprogesterone Co. (EP) was injected i.m. into female Wistar rats, different strains of mice of both sex and Syrian golden hamsters with doses of 5-100 times the human contraceptive dose once or twice a month for 10-32 times. In some experiments EP was combined with whole-body 3 Gy gamma ray radiation once or twice. Results show that EP has obvious carcinogenicity and can enhance the gamma ray carcinogenicity, thereby increasing the tumor incidence or the ratio of malignant to benign tumours. Carcinogenic mechanisms of EP have also been studied.
Gao
F M
FM
Laboratory of Industrial Hygiene, Ministry of Public Health, Beijing, PRC.
Jiang
H Y
HY
Yu
Y N
YN
Li
X L
XL
Wang
W H
WH
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D006224:Cricetinae; D003692:Delayed-Action Preparations; D004622:Embryo, Mammalian / Q000166:cytology; D004958:Estradiol / Q000031:analogs & derivatives / Q000633:toxicity; D004965:Estrogen Antagonists / Q000633:toxicity*; D005260:Female; D006908:Hydroxyprogesterones / Q000633:toxicity*; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D003037:Cobalt Radioisotopes; D003692:Delayed-Action Preparations; D004965:Estrogen Antagonists; D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate; D004958:Estradiol