Chronic rejection in single-lung transplantation manifested by obliterative bronchiolitis.
Chronic rejection of the lung in patients with heart-lung transplants has most often been associated with the development of obliterative bronchiolitis. Previously only one patient receiving a single-lung transplant suffered from the development of this problem. We describe a patient whose obliterative bronchiolitis developed 9 months after single-lung transplantation. Progressive deterioration occurred until his death from obliterative bronchiolitis at 21 months after transplantation. The functional and histologic changes are described and the possible mechanisms discussed.
LoCicero
J
J
Department of Surgery, Northwestern University Medical School, Chicago, Ill. 60611-3008.
Robinson
P G
PG
Fisher
M
M
D000368:Aged; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002908:Chronic Disease; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation; D008297:Male