Spontaneous amyloidosis in mice with malignant neoplasms.
An outbred strain of Swiss mice carrying malignant neoplasms (48 female with mammary carcinoma, 1 male with osteosarcoma) is described with a high frequency of amyloid deposits selectively located in the ileum. Amyloid deposits were demonstrated by Congo red staining and electron microscopy. Comments are directed toward methods of amyloid detection, as well as pathogenic considerations.
Madi
K
K
Department of Pathology, School of Medicine, Federal University of Rio de Janeiro, Brasil.
De Paola
D
D
Duarte
F
F
Takyia
C
C
Lima
R J
RJ
D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D000818:Animals; D005260:Female; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000150:complications / Q000473:pathology*; D051379:Mice; D008854:Microscopy, Electron; D012516:Osteosarcoma / Q000150:complications / Q000473:pathology*