Synthetic biological response modifiers; Part 1. Synthesis and immunomodulatory properties of some N2-(omega-(hypoxanthin-9-yl)alkoxycarbonyl)-L-arginines.
The synthesis and the main chemical and physical properties of some N2-(omega-(hypoxanthin-9-yl)alkoxycarbonyl)-L-arginines are described. The ability of the synthesized compounds to modulate the natural cytotoxic response (NK cells) in mice has also been analyzed and described.
Stradi
R
R
Institute of Organic Chemistry, Faculty of Pharmacy, University of Milan.
Rossi
E
E
Perezzani
L
L
Migliorati
G
G
Riccardi
C
C
Cornaglia
G
G
Ferraris
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007042:Hypoxanthines / Q000138:chemical synthesis* / Q000494:pharmacology; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007042:Hypoxanthines; D007155:Immunologic Factors; D001120:Arginine