title: [Effect of induction methods of pediatric anesthesia on serum myoglobin].
abstract: Two hundred and twenty nine children from infancy to middle teens divided into six groups were studied to determine the effect of induction methods of pediatric general anesthesia on serum myoglobin. After the slow induction with nitrous oxide-oxygen-halothane (GOF), the serum myoglobin increased significantly to 1774.7 +/- 4285.8 ng.ml-1 (mean +/- SD) by iv administration of succinylcholine 1 mg.kg-1. This significant increase of serum myoglobin was reduced by pretreatment with d-tubocurarine (dTc) 0.05 mg.kg-1 before administration of succinylcholine. However, it was not reduced by pretreatment with thiopental 3 mg.kg-1. After the rapid induction with thiopental 5 mg.kg-1 and succinylcholine 1 mg.kg-1, the serum myoglobin increased slightly to 387.6 +/- 596.5 ng.ml-1. But this increase in serum myoglobin was stopped by pretreatment with dTc 0.05 mg.kg-1 before the rapid induction. Serum myoglobin was not changed without succinylcholine after the slow induction with GOF. In each group, there was no relation with serum myoglobin and ages or fasciculation. Serum myoglobin was more influenced by the induction methods of pediatric general anesthesia than by ages.
authors.affiliation: Department of Anesthesiology, Kanagawa Children's Medical Center, Yokohama.
authors.forename: N
authors.initials: N
authors.lastname: Sekino
authors.forename: K
authors.initials: K
authors.lastname: Hiroki
authors.forename: R
authors.initials: R
authors.lastname: Namatame
authors.forename: M
authors.initials: M
authors.lastname: Tano
authors.forename: O
authors.initials: O
authors.lastname: Fukatsu
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Fujihara
authors.forename: K
authors.initials: K
authors.lastname: Ogata
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009211:Myoglobin / Q000097:blood*; D010372:Pediatrics
chemical_list: D009211:Myoglobin