[The UV sensitivity of the bromodeoxyuridine-substituted chromosomes in the Chinese hamster].
Chinese hamster cells with chromosomes differently substituted for BUdR (TT-TT, TT-TB, TB-TB, TB-BB, where T is thymidine containing chromatid and B is BUdR substituted chromatid) were exposed to UV-light in phase G2 and chromosome aberrations (mainly chromatid breaks) were analysed. Breaks frequency per chromosome was proportional to BUdR content. No breaks were found in TT-TT chromosomes. The frequency of breaks per TB chromatid was similar with TT-TB and TB-BB chromosomes. In TB-BB chromosomes, however, virtually no breaks occurred in TB chromatids whereas in BB chromatids, their frequency was much higher than was expected.
Antoshchina
M M
MM
Luchnik
N V
NV
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D002842:Chromatids / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D011836:Radiation Tolerance / Q000187:drug effects*; D014466:Ultraviolet Rays
D001973:Bromodeoxyuridine
UF-chuvstvitel'nost' bromdezoksiuridin-zameshchennykh khromosom kitaĭskogo khomiachka.