title: [The transformation of the mammalian genome and the teratogenic activity of chloridin].
abstract: Susceptibility to the effect of teratogen chloridine of three generations produced from transgenic rats with human growth hormone gene was investigated. The offsprings were shown to reveal elevated teratogenic injury as compared with intact animals.
authors.forename: T V
authors.initials: TV
authors.lastname: Ignat'eva
authors.forename: N A
authors.initials: NA
authors.lastname: Chebotar'
authors.forename: A P
authors.initials: AP
authors.lastname: Dyban
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000235:genetics*; D000818:Animals; D030801:Animals, Genetically Modified; D003433:Crosses, Genetic; D004247:DNA / Q000187:drug effects / Q000235:genetics; D005260:Female; D005796:Genes / Q000187:drug effects*; D013006:Growth Hormone / Q000235:genetics; D006801:Humans; D008297:Male; D011739:Pyrimethamine / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014170:Transformation, Genetic / Q000187:drug effects*
chemical_list: D013006:Growth Hormone; D004247:DNA; D011739:Pyrimethamine
vernacular_title: Transformatsiia genoma mlekopitaiushchikh i teratogennaia aktivnost' khloridina.