title: [Methodology of clinical studies of myorelaxants].
abstract: Myorelaxants, a specific pharmacologic group, are often prescribed. However, for many molecules, therapeutic trial methodology is not adapted. A review of the fundamental aspects of pharmacological trial clearly show a need for diagnosis and inclusion criteria, definition and validation for methods of assessment, analysis of the dose-response curve on term of effectiveness according to the pharmacologic and clinically established rules. Rational prescription of myorelaxants will arise from this principles.
authors.affiliation: Système Nerveux et de l'Appareil Locomoteur, CHU Timone, Marseille.
authors.forename: O
authors.initials: O
authors.lastname: Blin
authors.forename: R
authors.initials: R
authors.lastname: Guieu
authors.forename: C
authors.initials: C
authors.lastname: Desnuelle
authors.forename: G
authors.initials: G
authors.lastname: Serratrice
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D013673:Technology Assessment, Biomedical
chemical_list: D009125:Muscle Relaxants, Central
vernacular_title: Méthodologie des études cliniques des myorelaxants.