The effect of post-natal malnutrition on pepsinogen secretion receptors in weanling rats.
Post-natal malnutrition was induced in rats using the expanded litter model. Pepsinogen secretion of isolated gastric glands in response to several secretagogues was measured. Malnourished 19-day-old pups showed no response to carbachol, CCK-8, gastrin, secretin and ionophore A23187 compared to well-nourished animals, but showed comparable secretion of pepsinogen after stimulation with dibutyryl cAMP (DiBcAMP). Hydrocortisone treatment for 48 h caused increased pepsinogen accumulation and elevated pepsinogen secretory responsiveness to carbachol and secretin of gastric glands isolated from post-natal malnourished pups. Our results indicate that isolated gastric glands obtained from well-nourished rat possess two functionally distinct receptors for gastrin and C-terminal fragment of CCK. Our study supports the concept that in malnourished rats there is a decreased number of binding sites or/and some post-receptor defects. Pepsinogen release mechanisms remain unaffected.
Yahav
J
J
Pediatric Gastroenterology Service, SHEBA Medical Centre, Tel-Hashomer, Israel.
Fradkin
A
A
Diver-Haber
A
A
Jonas
A
A
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005753:Gastric Mucosa / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D009748:Nutrition Disorders / Q000378:metabolism*; D010435:Pepsinogens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000378:metabolism*
D010435:Pepsinogens; D011949:Receptors, Cholecystokinin; D006854:Hydrocortisone