[Effects of chorionic gonadotropin on the hematopoietic stem cells].
It was shown on the exogenic colony-forming unit (CFU) assay that the chorionic gonadotropin (CG) administration to female mice CBA in doses correlating with its concentration in different stages of woman pregnancy stimulated (depending upon the doses) the CFU formation of bone marrow, but not spleen origin. Injections of CG to the ovariectomized mice has the opposite (inhibited) effect on the CFU contents in bone marrow and spleen. CG-administration in the dose of 40 U1 to the ovariectomized and non-castrated irradiated recipients bone marrow cells stimulates (statistically significant) colonies formation. As for 200 U1 dose hormone has the similar effect only on the non-castrated animals.
Shirshev
G V
GV
Kevorkov
N N
NN
D000818:Animals; D001854:Bone Marrow Cells; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010052:Ovariectomy; D011247:Pregnancy; D013154:Spleen / Q000166:cytology; D013268:Stimulation, Chemical
D006063:Chorionic Gonadotropin
Vliianie khorionicheskogo gonadotropina na stvolovye krovetvornye kletki.