Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and 1-substituted benzothieno[2,3-d]imidazoles.
The synthesis of 1-substituted benzothieno[2,3-d]imidazoles and their most suitable synthesis precursor 2-nitro-3-substituted-amino benzo[b]thiophenes is reported. Most of these latter compounds show analgesic and antiinflammatory activities sometimes comparable to those of phenylbutazone with less toxicity and gastric lesivity.
Guerrera
F
F
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italia.
Salerno
L
L
Siracusa
M A
MA
Ronsisvalle
G
G
Caruso
A
A
Leone
M G
MG
Felice
A
A
D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005122:Exudates and Transudates / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D009574:Nitro Compounds; D013876:Thiophenes