Synthesis of some 1,4-dihydropyridine derivatives and their calcium antagonistic activity.
Seven new 2,6-dimethyl-3,5-diacetyl-4-aryl-1,4-dihydropyridine derivatives have been prepared. Their structures have been elucidated by UV, IR, 1H-NMR and elementary analysis. The calcium antagonistic activity of these compounds were tested in K(+)-depolarized taenia coli precontracted with 1 mmol/l Ca2+.
Safak
C
C
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Hacettepe, Ankara, Turkey.
Sahin
I
I
Sunal
R
R
D000818:Animals; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000032:analysis / Q000138:chemical synthesis*; D002432:Cecum / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D011188:Potassium; D002118:Calcium