Transferrin receptors in injured brain.
Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells, probably macrophages. Although Tf-R were seen in proliferating cells, Tf-R were also observed in non-proliferating cells, many of them macrophages. The receptors perhaps bind transferrin in edema fluid and play an important role in lesion repair.
Orita
T
T
Department of Neurosurgery, Yamaguchi University School of Medicine, Ube.
Akimura
T
T
Nishizaki
T
T
Kamiryo
T
T
Ikeyama
Y
Y
Aoki
H
H
Ito
H
H
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011990:Receptors, Transferrin / Q000378:metabolism*
D008562:Membrane Glycoproteins; D011990:Receptors, Transferrin