title: Single-phase methylene diphosphate bone scintigraphy in the diagnostic evaluation of dogs with osteosarcoma.
abstract: In this study, 25 dogs each with a histopathologically diagnosed appendicular or axial osteosarcoma were prospectively and consecutively examined by methylene diphosphate nuclear scintigraphy. Scannings that revealed scintigraphically enhanced focal increased activity via bone uptake of the 99mTc methylene diphosphate radionuclide at sites other than the primary tumor site were compared with scintigrams obtained from dogs without osteosarcoma. Secondary scintigraphic sites were evaluated by survey radiography and, if possible, by histologic examination (biopsy or necropsy specimens). On the basis of our findings, scintigraphy seems to be more efficient than physical examination and radiographic bone survey for the diagnosis of multicentric, metachronous, or metastatic canine osteosarcoma.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
authors.forename: K A
authors.initials: KA
authors.lastname: Hahn
authors.forename: C
authors.initials: C
authors.lastname: Hurd
authors.forename: H D
authors.initials: HD
authors.lastname: Cantwell
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000662:veterinary*; D011446:Prospective Studies; D011859:Radiography; D011877:Radionuclide Imaging