Molecular analysis of Hodgkin's disease with abundant Reed-Sternberg cells.
The pathogenesis of Hodgkin's disease (HD) has been elusive largely because of the paucity of the Reed-Sternberg cells in comparison to large numbers of normal inflammatory cells in biopsy specimens. This report attempts to characterize Hodgkin's disease by studying subtypes with a high proportion of Reed-Sternberg cells and their variants. We found in 4 out of 6 cases, clonal heavy and light chain immunoglobulin (Ig) gene rearrangements. The Ig rearrangement results are compared with the proportion of RS cells seen in the biopsy specimens and the data are correlated with the current literature.
Hu
E H
EH
Department of Hematology, University of Southern California Medical Center, Los Angeles.
Ellison
D
D
Zovich
D
D
Nichols
P
P
Pattengale
P
P
D002452:Cell Count / Q000379:methods; D003001:Cloning, Molecular; D015321:Gene Rearrangement / Q000276:immunology; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D010641:Phenotype