title: The serological response to a thermostable Vero cell-adapted rinderpest vaccine under field conditions in Niger.
abstract: A lyophilized thermostable Vero cell-adapted ringerpest vaccine, stabilized with lactalbumin hydrolysate and sucrose, was tested for safety, serological response and suitability for use with an abbreviated cold chain under field conditions in Niger. A total of 480 cattle, 90 goats and 55 sheep of unknown serological status were vaccinated on government ranches and observed for at least 22 days. No untoward effects of the vaccine were detected. The serological response to the vaccine stored at environmental temperatures for 30 to 34 days was determined in 144 previously unvaccinated yearling calves. Seroconversion was demonstrated in 98% of the yearling calves using seroneutralization. The un-refrigerated vaccine retained a titer of 3.69 log10 TCID50 per dose through day 34.
authors.affiliation: USDA, Foreign Animal Disease Diagnostic Laboratory, Greenport, NY 11944.
authors.forename: J C
authors.initials: JC
authors.lastname: Mariner
authors.forename: M C
authors.initials: MC
authors.lastname: van den Ende
authors.forename: J A
authors.initials: JA
authors.lastname: House
authors.forename: C A
authors.initials: CA
authors.lastname: Mebus
authors.forename: S
authors.initials: S
authors.lastname: Salifou
authors.forename: C
authors.initials: C
authors.lastname: Stem
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology; D015511:Goat Diseases / Q000276:immunology; D006041:Goats; D009500:Neutralization Tests; D009548:Niger; D012301:Rinderpest / Q000276:immunology*; D012302:Rinderpest virus / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology; D013696:Temperature; D014709:Vero Cells; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines