Anti-complementary and hypoglycemic activities of the glycans from the seeds of Malva verticillata.
Seven polysaccharides and peptidoglycans obtained from the seeds of Malva verticillata were tested for anti-complementary activity. Remarkable activities were observed for MVS-I and MVS-IIA. The former is mainly composed of beta-1,3-linked D-glucan and of alpha-1,5-linked L-arabino-beta-3,6-branched D-galactan, and the latter is essentially alpha-1,5-linked L-arabino-beta-3,6-branched D-galactan. Further, considerable activities were observed for MVS-IIIA and MVS-IVA. Both glycans possess arabino-3,6-galactan moieties accompanying alpha-1,3-linked L-arabinopyranosyl, beta-1,4-linked D-xylosyl, and alpha-1,4-linked D-galacturonic acid units. In addition, the major neutral polysaccharide (MVS-I), the major peptidoglycan (MVS-V), and the polysaccharide-rich fraction (MVS-V-CH) obtained from MVS-V were tested for hypoglycemic activity. MVS-I especially showed remarkable activity, and MVS-V-CH also exhibited significant activity. From the viewpoint of structural features, the latter belongs to pectic substances.
Tomoda
M
M
Kyoritsu College of Pharmacy, Tokyo, Japan.
Shimizu
N
N
Gonda
R
R
Kanari
M
M
Yamada
H
H
Hikino
H
H
D000818:Animals; D002240:Carbohydrate Sequence; D003169:Complement Inactivator Proteins / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000032:analysis
D003169:Complement Inactivator Proteins; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D011134:Polysaccharides