Formation of a nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline by photo-irradiation.
A direct-acting mutagen to Salmonella typhimurium TA98 was found to be formed by exposing 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) in acetone to sunlight for 60 min. The direct-acting mutagen in the irradiated sample was purified by HPLC and identified as 3,4-dimethyl-2-nitroimidazo-[4,5-f]quinoline (NO2-MeIQ). The yield of NO2-MeIQ from MeIQ was estimated to be 0.3%.
Hirose
M
M
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
Wakabayashi
K
K
Grivas
S
S
De Flora
S
S
Arakawa
N
N
Nagao
M
M
Sugimura
T
T
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000302:isolation & purification; D010777:Photochemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet
D009593:Nitroimidazoles; D011804:Quinolines; C064039:3,4-dimethyl-2-nitroimidazo-(4,5-f)quinoline; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline