Correction of arterial blood pressure in adult rats with inherited stress-induced arterial hypertension by enhancement of catecholamine metabolism in early postnatal period.
A long-lasting decrease of the basal and stress-induced arterial blood pressure was obtained in rats with inherited emotional stress-induced hypertension by means of injections of the dopamine precursor L-DOPA during early postnatal ontogeny (21-25 days of the life). "Permanent" hypotensive effect of L-DOPA was caused by the elevation of the brain but not peripheral catecholamine levels and was not related to a stimulation of the hypothalamic-pituitary-adrenocortical system in response to administration of the dopamine precursor. The restoring effect of L-DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline.
Naumenko
E V
EV
Institute of Cytology and Genetics, Siberian Department of the Academy of Sciences of the U.S.S.R., Novosibirsk.
Maslova
L N
LN
Markel
A L
AL
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications*
D002395:Catecholamines; D007980:Levodopa