Gallstone formation associated with weight reduction.
The author presents the case history of an obese patient in whom gallstones developed 5 months after she began a weight-loss program. Conservative management with chenodeoxycholic acid completely resolved cholelithiasis following four months of treatment. Gallstone-formation has traditionally been attributed to supersaturation of bile with cholesterol. However, the author proposes that the formation of gallstones may also be related to a change in gallbladder mechanics stimulated by dieting over an extended period. Recognition of this risk can lead to early diagnosis of gallstones, thus enhancing effective treatment by conservative methods.
Dickerman
J L
JL
D000328:Adult; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D004038:Diet, Reducing / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009765:Obesity / Q000178:diet therapy*; D011859:Radiography
D002635:Chenodeoxycholic Acid