title: [Photodynamic effects of a concanavalin A-chlorin e6 conjugate on human fibroblasts].
abstract: To minimize the side effect of porphyrin photosensitizers and to reduce their active concentration, chlorine e6 was conjugated with concanavalin A. Photodynamic action of chlorine e6 and concanavalin A-chlorine e6 conjugate has been studied in human skin embryonic fibroblasts. The conjugate appeared to be 5 times more effective as compared to chlorine e6 due to concanavalin A-chlorine e6 endocytosis into intracellular compartments.
authors.forename: T V
authors.initials: TV
authors.lastname: Akhlynina
authors.forename: P V
authors.initials: PV
authors.lastname: Gulak
authors.forename: N V
authors.initials: NV
authors.lastname: Serebriakova
authors.forename: A A
authors.initials: AA
authors.lastname: Rozenkrants
authors.forename: A S
authors.initials: AS
authors.lastname: Sobolev
mesh_terms: D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D003470:Culture Media; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects
chemical_list: D003470:Culture Media; D011166:Porphyrins; D003208:Concanavalin A; C006969:chlorin
vernacular_title: Fotodinamicheskoe deĭstvie kon"iugata konkanavalina A s khlorinom e6 na fibroblasty cheloveka.