Alcohol, beer and cancer of the pancreas.
The relationship between total alcohol consumption and intake of beer, wine and spirits and the risk of cancer of the pancreas was re-assessed in a pooled analysis of 3 case-control studies of pancreatic cancer from Italy, France and Switzerland, providing a total data-set of 494 cases and 1,704 controls. Logistic regression was used to obtain relative risks adjusted for study, age, sex, smoking and socio-economic status. Relative to non-drinkers, the risk estimates for subsequent levels of alcohol consumption were close to unity, and there was no evidence of a trend in risk with dose: the point estimate for more than 8 drinks per day was 0.8 (95% Confidence Interval, CI = 0.5-1.3). Likewise, no consistent association was observed for consumption of wine, beer or spirits: the relative risks for the highest consumption levels were 1.0 for wine, 0.9 for beer and 0.9 for spirits. No significant interaction was observed with study centre, sex or smoking habits. Given the large size of the data-set, of the consistency and the replication of findings across the 3 different studies, and of the elevated alcohol consumption of these populations, the present analysis gives reassuring evidence on the alcohol and pancreatic cancer issue in relation to total consumption of alcohol, of beer and of other alcoholic beverages.
Bouchardy
C
C
Registre Genevois des Tumeurs, Geneva, Switzerland.
Clavel
F
F
La Vecchia
C
C
Raymond
L
L
Boyle
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D000434:Alcoholic Beverages / Q000009:adverse effects*; D001515:Beer / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005602:France; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D013557:Switzerland; D014920:Wine / Q000009:adverse effects