title: [Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process].
abstract: Mechanism of the activation of 5-lipoxygenase (EC 1.13.11.12) has been investigated and shown to have the allosteric character. Limitations of the activator structure are formulated.
authors.forename: I A
authors.initials: IA
authors.lastname: Butovich
authors.forename: V A
authors.initials: VA
authors.lastname: Soloshonok
authors.forename: V A
authors.initials: VA
authors.lastname: Solodenko
authors.forename: V P
authors.initials: VP
authors.lastname: Kukhar'
mesh_terms: D000494:Allosteric Regulation; D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D002264:Carboxylic Acids / Q000494:pharmacology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013379:Substrate Specificity; D013451:Sulfonic Acids / Q000494:pharmacology*
chemical_list: D002264:Carboxylic Acids; D008041:Linoleic Acids; D016859:Lipoxygenase Inhibitors; D009943:Organophosphorus Compounds; D013451:Sulfonic Acids; D019787:Linoleic Acid; D001091:Arachidonate Lipoxygenases
vernacular_title: Aktivatsiia 5-lipoksigenazy lipofil'nymi n-alkilsoderzhashchimi kislotami--allostericheskiĭ protsess.