Experimental treatment of chronic lymphocytic leukemia with extracorporeal photochemotherapy. Initial observations.
Based on the encouraging results obtained with extracorporeal photochemotherapy (EP) in the treatment of the exfoliative erythrodermic form of cutaneous T-cell lymphoma (CTCL), leukemic form, as well as other T-cell-mediated diseases we evaluated the therapeutic potential of EP in patients with chronic lymphocytic leukemia (B-CLL). Three patients with B-CLL were treated for a period of 1 year. Two patients showed stabilization of disease, as demonstrated by reduction in their peripheral white blood cell count, with one patient showing lymph-node resolution. A third patient with significant intolerance to previous chemotherapy did not respond within the observed period. No significant side effects of EP were observed. Our observations suggest that EP may have a positive effect on the course of B-CLL in selected patients. Additional clinical trials are warranted to further define the role of EP alone or in combination therapy in the management of B-CLL.
Knobler
R M
RM
Department of Dermatology II, University of Vienna, Austria.
Pirker
R
R
Kokoschka
E M
EM
Ludwig
H
H
Linkesch
W
W
Micksche
M
M
D000328:Adult; D004341:Drug Evaluation; D005112:Extracorporeal Circulation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000503:physiopathology; D008730:Methoxsalen / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010778:Photochemotherapy; D010865:Pilot Projects; D014466:Ultraviolet Rays
D008730:Methoxsalen