title: [Toxicity of cis-platinum loaded with lactic acid oligomer microspheres in mice].
abstract: We have evaluated the acute toxicity of an experimental new dosage form administered intraperitoneally in mice, consisting of cis-platinum loaded with lactic acid oligomer microspheres (CDDP-ms). The LD50 value of the CDDP-ms was 23.8 mg/kg, which amounted to 176% of the LD50 of the cis-platinum solution (13.5 mg/kg). Autopsy findings revealed no additional toxicity due to this dosage form.
authors.affiliation: 1st Dept. of Surgery, Kyoto Prefectural Univ.
authors.forename: T
authors.initials: T
authors.lastname: Sasabe
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: A
authors.initials: A
authors.lastname: Iwamoto
authors.forename: M
authors.initials: M
authors.lastname: Shimotsuma
authors.forename: C
authors.initials: C
authors.lastname: Yoneyama
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: S H
authors.initials: SH
authors.lastname: Hyon
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Kusanoi
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D011108:Polymers
chemical_list: D007773:Lactates; D011108:Polymers; D019344:Lactic Acid; D002945:Cisplatin