title: A simple perfusion system for measuring endogenous retinal dopamine release.
abstract: A simple superperfusion apparatus for measuring endogenous dopamine (DA) release from rat retina is described. DA release is stimulated by increasing levels of potassium (K) in the superfusion medium and this K-stimulated release is calcium dependent. Exposure of dark-adapted retinae to light also increases endogenous DA release. This system should prove useful in determining what factors may control endogenous DA release in the retina.
authors.affiliation: Department of Pathology, University of Western Ontario, London, Canada.
authors.forename: C J
authors.initials: CJ
authors.lastname: Gibson
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion / Q000379:methods*; D010775:Photic Stimulation; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
chemical_list: D011188:Potassium; D004298:Dopamine