Potential antitumour agents. Synthesis, DNA binding studies and biological activity of 9-aminoacridinyl derivatives of citrulline and arginine.
The synthesis and characterisation of the 9-acridinyl derivatives of citrulline and arginine are reported together with studies on the intercalation of these compounds into DNA. The antitumour activity of these compounds in vitro against two cell lines is also reported.
Rad-niknam
M
M
Department of Pharmacy, University of Manchester, UK.
Sharples
D
D
D000585:Aminacrine / Q000031:analogs & derivatives*; D000609:Aminoacridines; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001120:Arginine / Q000031:analogs & derivatives*; D002453:Cell Cycle / Q000187:drug effects; D002956:Citrulline / Q000031:analogs & derivatives*; D004247:DNA / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D000609:Aminoacridines; D000970:Antineoplastic Agents; D002956:Citrulline; D000585:Aminacrine; D004247:DNA; D001120:Arginine