[Experimental studies of the possibilities of radioimmunodetection of cancer of the large intestine by subcutaneous administration of iodinated antibodies to intestinal antigen beta1-MA].
131I- and 125I-labeled rabbit antibodies (AB) to the specific human intestinal beta 1MA were administered sc and iv to nude mice xenografts of human colon carcinoma. A study was made of the pharmacokinetics of labeled AB in the recipients' organs and tissues, measuring the radioactivity of tissue specimens on days 2, 3, 4 and 7 after injection with a gamma-counter, calculating specific radioactivity and accumulation indices. Tumors were visualized with a gamma-camera and a scanner. Proceeding from the comparison of the results of sc and iv administration of iodinated AB, a conclusion has been made of the applicability of sc injections of the agent for immunoscintigraphy.
Aleksander
S K
SK
Fidler
L M
LM
Mit'kov
V V
VV
Pugachev
K K
KK
Avdeev
G I
GI
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D007420:Intestine, Large; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011877:Radionuclide Imaging; D012004:Rectal Neoplasms / Q000276:immunology
D000906:Antibodies; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
Eksperimental'noe izuchenie vozmozhnosti radioimmunodetektsii rakatolstoĭ kishki pri podkozhnoĭ vvedenii ĭodirovannykh antitel k kishechnomu antigenu beta1 MA.