title: Ibotenic acid lesions of the basal forebrain cholinergic system retard amygdala kindling.
abstract: The effect of ibotenate lesions of septum and substantia innominata on electrical kindling of the amygdala was investigated in rats. The lesions significantly retarded kindling in the absence of a change in initial seizure sensitivity. This suggests that cholinergic neurotransmission can contribute to, but is not crucial for, amygdala kindling, and that a major component of the cholinergic circuitry involved in amygdala kindling may originate in the septum or substantia innominata or both.
authors.affiliation: Department of Psychology, University of Western Ontario, London, Canada.
authors.forename: D P
authors.initials: DP
authors.lastname: Cain
authors.forename: D J
authors.initials: DJ
authors.lastname: Stewart
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D007051:Ibotenic Acid / Q000633:toxicity; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats
chemical_list: D007051:Ibotenic Acid