title: Cajal-Retzius neurons in developing monkey neocortex show immunoreactivity for calcium binding proteins.
abstract: Immunoreactivity for two calcium binding proteins, 28 kDa calbindin and parvalbumin, was used to label cells morphologically identical to Cajal-Retzius neurons in the developing visual, prefrontal, sensory-motor and temporal cortex of Old World monkeys. At all fetal ages examined (E110-E155), Cajal-Retzius neurons throughout the cortex were immunoreactive for calbindin as well as being acetylcholinesterase positive. Between E130 and E150, the calbindin-immunoreactive Cajal-Retzius cells in the visual cortex, and a few in other cortical areas, also showed parvalbumin immunoreactivity. A reduced population of immunoreactive Cajal-Retzius cells was detected at birth, and none could be visualized by immunocytochemistry or histochemistry at later postnatal ages. Calbindin and parvalbumin immunoreactivity represents a potentially useful marker for this developmentally regulated population of neurons, and the varied expression of the two proteins suggests that Cajal-Retzius neurons may represent a neurochemically heterogeneous cell population.
authors.affiliation: Department of Anatomy and Neurobiology, University of California, Irvine 92717.
authors.forename: G W
authors.initials: GW
authors.lastname: Huntley
authors.forename: E G
authors.initials: EG
authors.lastname: Jones
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D064026:Calbindins; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D007150:Immunohistochemistry; D008251:Macaca / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*
chemical_list: D064026:Calbindins; D002135:Calcium-Binding Proteins; D009124:Muscle Proteins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D000110:Acetylcholinesterase