Placetins, platelet aggregation inhibitors from Streptomyces sp. Q-1043. I. Fermentation, isolation and biological properties.
Placetins, platelet aggregation inhibitors were obtained from the culture broth of Streptomyces sp. Q-1043. These were designated placetins A, A1, B and B1, respectively. Placetins A and B showed strong cytotoxicities against P388, L1210 and HeLa cells.
Ozasa
T
T
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Suzuki
K
K
Yamada
T
T
Suzaki
K
K
Nohara
C
C
Kobori
M
M
Saito
T
T
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001685:Biological Factors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D007941:Leukemia P388; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D001685:Biological Factors; D010975:Platelet Aggregation Inhibitors