title: [Is the progesterone test a generalizable method of screening for neoplastic and preneoplastic lesions of the endometrium?].
abstract: A "progesterone test" has recently been proposed as a tentative method to detect early neoplastic and pre-neoplastic lesions of the uterus endometrium. At the time progesterone is stopped, a "deprivation" metrorragia demonstrates a remanent hyperoestrogenism, which represents a well-known risk factor for this type of lesion. The method has been evaluated in private practice; 389 patients were offered the test: 87% accepted. Metrorragias were observed in 28% of the cases; however, no neoplastic nor pre-neoplastic lesions could be detected in this group of patients. Moreover, one patient presented with an advanced endometrial cancer one year after a negative test. The reliability of such a test clearly needs further evaluation.
authors.affiliation: Médecins généralistes, Manche, France.
authors.forename: A
authors.initials: A
authors.lastname: Viel
authors.forename: J L
authors.initials: JL
authors.lastname: Goriaux
authors.forename: J C
authors.initials: JC
authors.lastname: Rouge
authors.forename: H
authors.initials: H
authors.lastname: Crouet
authors.forename: J F
authors.initials: JF
authors.lastname: Héron
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008234:Lynestrenol / Q000494:pharmacology; D008403:Mass Screening / Q000191:economics; D008593:Menopause; D008796:Metrorrhagia / Q000209:etiology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000628:therapy; D014594:Uterine Neoplasms / Q000517:prevention & control*
chemical_list: D008234:Lynestrenol
vernacular_title: Le "test à la progestérone" est-il la méthode généralisable de dépistage des lésions néoplasiques et prénéoplasiques de l'endomètre?