[Structure of the liver after correction of experimental chronic hepatitis with benzonal and potassium orotate].
As a result of the experimental investigation of the liver damaged with CCL4, its essential structural changes have been revealed. They resemble those specific for a chronic toxic hepatitis. Administration of potassium orothate (100 mg/kg) increases proliferative activity of hepatocytes without any essential influence on intracellular regeneration. Under conditions of a delayed differentiation and lack of resorption of an abundantly outgrowing connective tissue, this results in a more profound pathological process in the liver. Benzonal administration (50 mg/kg) facilitates structural normalization of the chronically damaged liver, owing to activation of both cellular and intracellular regeneration.
Baĭbekova
E M
EM
Sultanova
L I
LI
D000818:Animals; D001463:Barbiturates / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D004359:Drug Therapy, Combination; D006520:Hepatitis, Animal / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009963:Orotic Acid / Q000627:therapeutic use*; D051381:Rats
D001463:Barbiturates; D009963:Orotic Acid; C002915:benzobarbital
Struktura pecheni pri korrektsii éksperimental'nogo khronicheskogo gepatita benzonalom i orotatom kaliia.