title: Factors predisposing to renal scarring: following staged reconstruction of classical bladder exstrophy.
abstract: Preservation of renal function is one of the major goals of staged reconstruction of bladder exstrophy. In 68 exstrophy patients who have completed staged reconstruction, 10 (14.7%) have developed renal scarring. A multiple factorial analysis of these patients showed the following factors to be statistically related to the development of renal scarring: (1) one or more febrile urinary tract infections prior to bladder neck reconstruction (P less than .001); (2) failure to utilize antibiotic prophylaxis following initial bladder closure (P less than .005); (3) elevated urinary residuals greater than 50 mL (P less than .02); (4) a diagnosis of elevated urinary residuals greater than 6 months following the onset of continence (P less than .001); and (5) one or more febrile urinary tract infections following bladder neck reconstruction (P less than .005).
authors.affiliation: Hospital for Sick Children, Toronto, Ontario.
authors.forename: D A
authors.initials: DA
authors.lastname: Husmann
authors.forename: G A
authors.initials: GA
authors.lastname: McLorie
authors.forename: B M
authors.initials: BM
authors.lastname: Churchill
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001746:Bladder Exstrophy / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D011183:Postoperative Complications; D014517:Ureteral Obstruction / Q000209:etiology; D014549:Urinary Incontinence / Q000209:etiology; D014552:Urinary Tract Infections / Q000150:complications / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents