title: A three-dimensional reconstruction of metastatic adenocarcinoma in lymph node.
abstract: Lymph nodes are a common site of metastatic cancer. The ability to view the three-dimensional configuration of complex biological structures, rendered in solid model form, might help to further elucidate the pathophysiology of metastatic disease. This paper presents a method for three-dimensional reconstruction from serial sections of a lymph node containing metastatic adenocarcinoma. The reconstruction and subsequent animation were carried out using the P3D graphics software (developed at the Pittsburgh Supercomputing Center) and rendered by the Dore high-speed renderer on an Ardent Titan graphics workstation. As different views of the model were produced, they were recorded a frame at a time on U-matic video tape. A three-dimensional solid-modeled object portrays metastatic, neoplastic elements within a lymph node.
authors.affiliation: Institute of Pathology, Shadyside Hospital, Pittsburgh, PA 15232.
authors.forename: R H
authors.initials: RH
authors.lastname: Siderits
authors.forename: C J
authors.initials: CJ
authors.lastname: Evans
authors.forename: J S
authors.initials: JS
authors.lastname: Welling
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008954:Models, Biological