Sodium and water intake of sheep, rabbits and cattle during ICV infusion of eledoisin.
The present study reports the effects of ICV administered eledoisin, the most potent anti/dipsogenic member of the tachykinin family, in three species. Sheep with chronic parotid fistula lost daily 200-400 mmol sodium in 3-4 l of saliva. During ICV infusion of eledoisin, 2 to 50 ng/min, a decrease in sodium intake was observed. If water was withheld for 22 hours, sheep normally drank 5.4 l water on presentation. During ICV infusion of eledoisin, 50 ng/min, water intake increased significantly. Wild rabbits lost 5 mmol sodium in 50 ml of urine after injection of furosemide. During ICV infusion of eledoisin, 30 ng/min, a decrease in sodium intake and an increase in water drinking was observed. Cows prepared with parotid fistula had access to sodium solution every other day to replace salivary sodium loss. During ICV infusion of eledoisin, 50 and 150 ng/min, a decrease in sodium intake occurred, and water intake was unaffected. These results confirm that central administration of eledoisin specifically influences ingestive behaviour in mammals and draws attention to some species differences in the observed effects.
Tarjan
E
E
Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia.
Blair-West
J R
JR
de Caro
G
G
Denton
D A
DA
McBurnie
M I
MI
Massi
M
M
Szmydynger-Chodobska
J
J
Weisinger
R S
RS
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D002417:Cattle; D002552:Cerebral Ventricles; D004326:Drinking / Q000187:drug effects*; D004600:Eledoisin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D012756:Sheep; D012964:Sodium / Q000172:deficiency; D012982:Sodium, Dietary; D013045:Species Specificity; D013894:Thirst / Q000187:drug effects*; D014868:Water Deprivation
D012982:Sodium, Dietary; D004600:Eledoisin; D005665:Furosemide; D012964:Sodium