Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats.
Adult male rats receiving tris(2-ethyl hexyl)trimellitate (TOTM) intraperitoneally for seven days exhibited no significant changes in the activities of hepatic aminopyrine-N-demethylase, aryl hydrocarbon hydroxylase or glutathione-S-transferase, or in the glutathione contents. However, except for the glutathione level, the di(2-ethyl hexyl)phthalate (DEHP)-treated group showed significant increases in the activities of these enzymes. Changes in the body weight and the absolute and relative liver weights were also observed among the DHEP-treated group.
Rathinam
K
K
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Biomedical Technology Wing, Poojapura Trivandrum, India.
Srivastava
S P
SP
Seth
P K
PK
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001565:Benzoates / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000633:toxicity*; D005982:Glutathione Transferase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D010795:Phthalic Acids / Q000633:toxicity*; D010968:Plasticizers / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D001565:Benzoates; D010795:Phthalic Acids; D010968:Plasticizers; C036101:tri-(2-ethylhexyl)trimellitate; D004051:Diethylhexyl Phthalate; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase; D005982:Glutathione Transferase