High predictivity of galactosyl-hydroxylysine in urine as an indicator of bone metastases from breast cancer.
We measured the urinary excretion of galactosyl-hydroxylysine (GH) and hydroxyproline in two groups of women with breast cancer, with (M+, n = 24) and without (Mo, n = 30) clinical, scintigraphic, or radiological evidence of bone metastases. Both these compounds are excreted in larger amounts in the M+ group than in the Mo patients. However, GH, which is a specific marker for bone collagen, provides better predictivity for bone metastases than does hydroxyproline: 92% sensitivity and 90% specificity vs 74% and 79%, respectively, for hydroxyproline.
Moro
L
L
Dipartimento di Biochimica, Università degli Studi de Trieste, Italy.
Gazzarrini
C
C
Modricky
C
C
Rovis
L
L
de Bernard
B
B
Galligioni
E
E
Crivellari
D
D
Morassut
S
S
Monfardini
S
S
D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology / Q000652:urine*; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000652:urine; D008991:Monitoring, Physiologic; D009362:Neoplasm Metastasis; D012306:Risk
D006901:Hydroxylysine; C007817:galactosylhydroxylysine