Are reduction potentials of antifungal agents relevant to activity?
Cyclic voltammetry data were obtained for several categories of fungicidal agents including quinones (akrobomycin, podosporin A), iminium ions and precursors (pyridazines, 15-azahomosterol, griseofulvin-4'-oxime), and metal derivatives of chelators (pyridine-2-aldehyde thiosemicarbazones). The reductions usually occurred in the range of -0.7 to +0.3 V. Reduction potentials provide information on the feasibility of electron transfer in vivo. Catalytic production of oxidative stress from redox cycling is a possible mode of action. Alternatively, there may be interference with normal electron transport chains.
Kovacic
P
P
Department of Chemistry, University of Wisconsin, Miwaukee 53201.
Kiser
P F
PF
Feinberg
B A
BA
D000935:Antifungal Agents / Q000032:analysis*; D002384:Catalysis; D002614:Chelating Agents / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D004579:Electron Transport; D007097:Imines / Q000032:analysis; D008670:Metals / Q000032:analysis; D010084:Oxidation-Reduction; D011809:Quinones / Q000032:analysis
D000935:Antifungal Agents; D002614:Chelating Agents; D007097:Imines; D008670:Metals; D011809:Quinones