Comparison of soft tissue effects of conventional ionic, low osmolar ionic and nonionic iodine containing contrast material in experimental animals.
Conventional, low osmolar, and non-ionic iodine containing contrast media and saline controls were placed in the paws, muscles, and subcutaneous tissues of Sprague-Dawley rat thighs. The paw injections were observed and photographed, while the thighs were examined histologically. Results showed that although the low osmolar and non-ionic agents did produce inflammatory reactions and focal necrosis in the soft tissues, they were much better tolerated than were the conventional ionic agents. A non-ionic or low osmolar ionic contrast agent should be strongly considered when a possibility for extravasation exists.
McAlister
W H
WH
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Mo.
Kissane
J M
JM
D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000473:pathology*; D005260:Female; D005552:Forelimb; D006801:Humans; D007455:Iodine / Q000009:adverse effects*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D007455:Iodine