Retrospective evaluation of recurrence after radical abdominal hysterectomy in patients with cervical carcinoma.
Out of total 176 patients with cervical carcinoma treated with radical abdominal hysterectomy at GCRI, 27 developed recurrence. The results of this study (Study A) were compared with the study carried out by Figge & Tamini, 1981 (Study B) and Thomas W. Burke, 1987 (Study C) as the approaches in all the three studies were more or less similar. The recurrence rates were 15.3%, 11.8% and 11.3% respectively in three studies. In cervical stage IB carcinoma, which is usually treated with this line of treatment, the recurrence rates were 20%, 12.3% and 11.3% respectively in three studies. The highest recurrence rates were observed in adenocarcinoma/adenosquamous carcinoma i.e. 50% in Study A, 33.3% in Study B and 17.4% in Study C. The adverse effects of high risk factors such as lymph node metastases and CLS involvement were less in Study A as compared to B. The deep stromal invasion was equally responsible in both the studies. The mean and median time interval until observed recurrence with post-operative radiotherapy were better in Studies B and A. Nearly 86% developed recurrence within 24 months which is useful observation for predicting the prognosis in similar situations. The evaluation and comparison of studies stresses the importance of new approaches to treatment on the current modalities as the present approach seems to be less effective especially in the presence of high risk factors.
Dave
K
K
Dpt. of Gynaec. Oncology, Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India.
Kapadia
A
A
D000230:Adenocarcinoma / Q000556:secondary*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D002296:Carcinosarcoma / Q000556:secondary*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000556:secondary*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*