title: Studies on bi-heterocyclic compounds. II. 5-substituted thiazolones.
abstract: Reactions of 4-methyl-2(3H)-thiazolones (5) with various N-alkoxycarbonyl pyridinium salts (6a--f) led to (N-alkoxycarbonyl dihydropyridyl)thiazolones (7a--f), oxidation of which yielded a new class of 5-pyridylthiazolones (8a--f). These reactions were applied to the synthesis of other azaarylthiazolones. Some of these azaarylthiazolones, particularly 5-(4-pyridyl)thiazolones (8b, c) and 5-(4-quinolyl)thiazolones (14a,b), showed positive inotropic activity with little chronotropic effect on guinea pig left atria.
authors.affiliation: Research Laboratory, Zenyaku Kogyo Co., Ltd., Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Takase
authors.forename: E
authors.initials: E
authors.lastname: Ohki
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009200:Myocardial Contraction / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D013844:Thiazoles