The effect of blood glucose concentration on postasphyxia cerebral hemodynamics in newborn lambs.
The effect of preasphyxia blood glucose concentration on postasphyxia (PA) cerebral hemodynamics was examined in 21 newborn lambs. Glucose was unregulated in one group (n = 7), and controlled throughout the study by glucose clamp in hyperglycemic (n = 7) and hypoglycemic (n = 7) groups. Cerebral blood flow, determined using radiolabelled microspheres, and arterial and sagittal sinus O2 contents were measured at control, 5 min, 1, 2, and 4 h after resuscitation from an asphyxial insult. Preasphyxia blood glucoses were 6.48 +/- 0.55 mM (mean +/- SEM), 12.08 +/- 0.80, and 2.66 +/- 0.14 in the three study groups. In all three groups, 5 min PA cerebral blood flow was significantly increased from control. In the late period after asphyxia, the unregulated group had decreased cerebral blood flow compared with control, 53.2 +/- 3.8 mL.100 g-1.min-1, mean +/- SEM, p less than 0.01; 49.6 +/- 2.0, p less than 0.005; 53.4 +/- 3.0, p less than 0.01, at 1, 2, and 4 h PA, respectively, versus 85.7 +/- 6.9 at control, whereas both the hyper- and hypoglycemic groups did not differ significantly from control measurements. Cerebral oxygen consumption (CMRO2) was significantly decreased in all three groups 5 min PA and remained decreased in the late period after asphyxia in both the unregulated and hypoglycemic groups. In the unregulated group, CMRO2 was 191 +/- 14 microM.100 g-1.min-1, mean +/- SEM, p less than 0.05; 200 +/- 4; and 181 +/- 10, p less than 0.05 at 1, 2, and 4 h, respectively, PA versus 251 +/- 12 at control.(ABSTRACT TRUNCATED AT 250 WORDS)
Rosenberg
A A
AA
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.
Murdaugh
E
E
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001237:Asphyxia / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006943:Hyperglycemia / Q000378:metabolism; D007003:Hypoglycemia / Q000378:metabolism; D010101:Oxygen Consumption; D012756:Sheep
D001786:Blood Glucose