Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, II. Effect on the in vitro induction of unscheduled DNA synthesis in rat, mouse, rabbit, hamster, and monkey primary hepatocytes.
2 hair dyes, HC Blue No. 1 and HC Blue No. 2, were evaluated for the in vitro induction of unscheduled DNA synthesis (UDS) in primary hepatocytes of rat, mouse, hamster, rabbit and monkey. NC Blue No. 1, which is identified as a carcinogen by the National Toxicology Program, induced UDS in all 5 systems. HC Blue No. 2, which is identified as a non-carcinogen, induced UDS in rat, mouse, hamster and rabbit primary hepatocytes. 3-Methylcholanthrene and methyl methanesulfonate were used as positive controls to determine the sensitivity of the test system.
Hill
L E
LE
Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, IN 46140.
Parton
J W
JW
Probst
G S
GS
Garriott
M L
ML
D000818:Animals; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects; D006202:Hair Dyes / Q000633:toxicity*; D006203:Hair Preparations / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009153:Mutagens; D010655:Phenylenediamines / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D013329:Structure-Activity Relationship
D006202:Hair Dyes; D006203:Hair Preparations; D009153:Mutagens; D010655:Phenylenediamines; C007906:N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene; C053869:HC Blue No. 2; D004247:DNA