Cyclosporin A levels in suction-blister fluid of patients with psoriasis treated systemically.
Oral cyclosporin A (CyA) is highly effective in the treatment of psoriasis. The long-term use is limited by dose-dependent side-effects, and the local concentration of CyA is a determining factor in treatment. The concentration of CyA in suction-blister fluid (SBF) and in whole blood was assessed using a polyclonal radioimmunoassay (RIA). This was carried out in patients with psoriasis following a single dose of CyA and while on adequate oral treatment with the drug. Peak blister fluid levels ranged from 32 to 170 ng/ml, and whole blood levels from 1250 to 2540 ng/ml. CyA trough levels (12 h following taking the drug) in the blister fluid ranged from 22 to 113 ng/ml, and in whole blood from 148 to 935 ng/ml. The trough concentrations in SBF were approximately 10% of whole blood trough levels.
Meinardi
M M
MM
Department of Dermatology, University of Amsterdam, The Netherlands.
Van Eendenburg
J P
JP
Oosting
J
J
Van Boxtel
C J
CJ
De Rie
M A
MA
Bos
J D
JD
D000328:Adult; D000368:Aged; D001768:Blister / Q000378:metabolism; D003524:Cyclosporins / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D005110:Extracellular Space / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D003524:Cyclosporins