Pharmacological effects of three phenylpropanoid glycosides from Mussatia.
The phenylpropanoid glycosides 1 (4-cinamoylmussatioside), 2 (4-dimethylcaffeoylmussatioside), and 3 (4-p-methoxycinnamoylmussatioside) isolated from the methanolic extract of Mussatia sp. showed inhibitory action on ADP-induced rat platelet aggregation. The order of activity was 1 greater than 2 greater than 3. This antiplatelet effect is likely to be related to the reported inhibition of cAMP-phosphodiesterase. On the other hand, compounds 1-3 had no effect on blood pressure and heart rate, on microbial growth, or on prostaglandin biosynthesis.
Cano
E
E
Departamento de Farmacología, Facultad de Farmacia, Santiago de Compostela, Spain.
Veiga
M
M
Jiménez
C
C
Riguera
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D010666:Phenylpropionates; D010946:Plants, Medicinal / Q000032:analysis*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000302:isolation & purification / Q000494:pharmacology*
D006027:Glycosides; D010666:Phenylpropionates; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D014312:Trisaccharides; C064379:4-cinnamoylmussatioside; C064381:4-(4-methyoxycinnamoyl)mussatioside; C064380:4-dimethylcaffeoylmussatioside