[Effects of continuous infusion of vasopressin on circadian rhythms of food and water intake, urine output and electrolyte excretion in Brattleboro rats].
Food intake (FI), water intake (WI), urine output (UO), Na+ and K+ excretions were investigated for 2 days at 4-h intervals during continuous infusion of saline or vasopressin (VP) 1.0 UI/day, in male Brattleboro vasopressin-deficient rats. Continuous VP infusion reduced significantly 24-h amounts of WI and UO, and increased Na+ excretion. A significant (3.5 h) phase advance of the circadian rhythm of WI was observed, while the group circadian rhythm of Na+ excretion was eliminated due to irregular phase shifts in the different rats. The results suggest that VP do not play a role in the generation of the circadian rhythms of water input and output, but it may participate in their internal synchronization.
Stoĭnev
A G
AG
Ikonomov
O Kh
OKh
D000818:Animals; D002940:Circadian Rhythm; D004326:Drinking; D004435:Eating; D007263:Infusions, Parenteral; D008297:Male; D011188:Potassium / Q000652:urine*; D051381:Rats; D011910:Rats, Brattleboro; D012964:Sodium / Q000652:urine*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014556:Urine; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology*
D014667:Vasopressins; D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium
Effekt postoiannoĭ infuzii vazopressinom na tsirkadiannye ritmy potrebleniia pishchi i vody, vydeleniia mochi i ékskretsii élektrolitov u krys Brattlboro.