Influence of N substitution on antimycobacterial activity of ciprofloxacin.
Ciprofloxacin analogs with various substitutions on the piperazine nitrogen were tested against several mycobacteria. In contrast to what has been found with other gram-positive and gram-negative bacteria, alkyl analogs such as N-isopropylciprofloxacin were shown to be significantly more active than ciprofloxacin. MICs of 0.125 microgram/ml against Mycobacterium tuberculosis were found.
Haemers
A
A
Department of Pharmaceutical Sciences, University of Antwerp, Belgium.
Leysen
D C
DC
Bollaert
W
W
Zhang
M Q
MQ
Pattyn
S R
SR
D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D002939:Ciprofloxacin