Inhibition of replication of human immunodeficiency virus by a heteropolyoxotungstate (PM-19).
A Keggin polyoxotungstate PM-19 K7[PTi2W10O40].6H2O was found to be a potent inhibitor of the replication of human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS), in OKT4+ cells. In contrast, the effect of HPA 23 (NH4)17Na[NaSb9W21O86], an inhibitor of reverse transcriptase of HIV, was not significant.
Inouye
Y
Y
School of Medicine Hiroshima University, Japan.
Take
Y
Y
Tokutake
Y
Y
Yoshida
T
T
Yamamoto
A
A
Yamase
T
T
Nakamura
S
S
D000998:Antiviral Agents / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D011108:Polymers / Q000494:pharmacology*; D014414:Tungsten / Q000494:pharmacology*; D017973:Tungsten Compounds; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011108:Polymers; D017973:Tungsten Compounds; C064098:polyoxotungstate PM 19; D014414:Tungsten