del(2)(p23): a new recurrent abnormality in acute myeloid leukemia.
In two patients with acute myeloid leukemia, we found a new chromosome abnormality: del(2)(p23) which was detected in 13% and 50% of studied bone marrow cells, respectively. In patient one, del(2p) was an additional abnormality to t(8;21), while patient two had del(2p) as the sole abnormality. Based on our observation and a review of the literature we propose that del(2p) is a new recurrent chromosome abnormality for acute myeloid leukemia.
Najfeld
V
V
Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, Mount Sinai Medical Center, New York, New York 10029.
Scalise
A
A
Fruchtman
S
S
Troy
K
K
D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*