A novel antibacterial diterpene from Premna schimperi.
A novel diterpene, (5R, 8R, 9S, 10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid, has been obtained from the leaves of Premna schimperi (Verbenaceae) using an anti-microbial bioassay-guided isolation procedure. The diterpene was identified on the basis of spectroscopic data and is active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis in the concentration range 20-25 micrograms ml-1.
Habtemariam
S
S
Department of Chemistry, Addis Ababa University, Ethiopia.
Gray
A I
AI
Halbert
G W
GW
Waterman
P G
PG
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*
D000900:Anti-Bacterial Agents; D004224:Diterpenes