[Clinical and immunologic effects following oral immunization against influenza in children in day care and infection susceptible young children].
57 infants and small children (9 months - 3.1 years) were orally immunized by an inactivated influenza vaccine (Mississippi 1/85; dosage: 110 micrograms HA); the control group (n = 15) received placebo. After three months the influenza specific Ig-concentrations of serum and secretions demonstrated a controverse course: Specific IgG (serum) decreased and specific IgA (nasale secretions) increased statistically significant (p less than 0.025), especially in children suffering from frequently relapsing respiratory infections (n = 31). Moreover the immunized children had also a better clinical outcome in the following 3 months: the number of days with cough, febrile symptoms and the antibiotics therapy were significantly decreased. Recommendations are given for an improvement of the orale influenza vaccine and its indicated administration in small children.
Wiersbitzky
S
S
Klinik für Kindermedizin, Ernst-Moritz-Arndt-Universität Greifswald.
Bruns
R
R
Seidel
E
E
Tischner
H
H
Broda
J
J
Gocht
A
A
Dorn
U
U
Luther
P
P
D000284:Administration, Oral; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002656:Child Day Care Centers; D002675:Child, Preschool; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000172:deficiency; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D009894:Opportunistic Infections / Q000517:prevention & control*; D012307:Risk Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
Klinische und immunologische Effekte nach oraler Immunisierung gegen Influenza bei Krippenkindern und infektanfälligen Kleinkindern.