title: Evaluation of a genus-specific monoclonal antibody in an amplified enzyme-linked immunoassay in the detection of Chlamydia in urine samples from men.
abstract: In this study, the authors used amplified enzyme-linked immunoassay (IDEIA Chlamydia test) on urine samples of 623 male patients attending a sexually transmitted disease clinic. They compared the results with routine urethral cell culture isolation, which showed a sensitivity and specificity of 72.6% and 98.6%, respectively. The sensitivity was significantly higher (79.7%) in patients with clinical evidence of urethritis as compared with those without such evidence (59%). The use of first-catch, early-morning urine may improve the sensitivity of the test.
authors.affiliation: Department of Genitourinary Medicine, General Hospital, Birmingham, United Kingdom.
authors.forename: A J
authors.initials: AJ
authors.lastname: Jawad
authors.forename: G
authors.initials: G
authors.lastname: Manuel
authors.forename: R
authors.initials: R
authors.lastname: Matthews
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: J C
authors.initials: JC
authors.lastname: Clay
mesh_terms: D000911:Antibodies, Monoclonal; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000652:urine; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D003470:Culture Media; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D014521:Urethra / Q000382:microbiology
chemical_list: D000911:Antibodies, Monoclonal; D003470:Culture Media