title: Evaluation of filarial skin test with Brugia malayi larval antigen in the field.
abstract: To obtain comparable and reproducible results by filaria skin test with B. malayi larval antigen, standard procedure has been evolved. Antigen protein of 2 micrograms per test, injected intracutaneously, was found optimum for positive skin reaction. The reaction ratio based on increase of wheal area by 2 times or more was found to be statistically significant for interpreting positive results. However, in larger field trials, the simpler measurement of increase of wheal diameter by 1 1/2 times or more was found to be equally reliable. Patients treated with diethylcarbamazine citrate, antihistaminics and anti-inflammatory drugs are likely to be unresponsive to filarial antigen and will yield incorrect information.
authors.affiliation: Division of Parasitology, King George's Medical College, Lucknow.
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.forename: K
authors.initials: K
authors.lastname: Tyagi
authors.forename: P K
authors.initials: PK
authors.lastname: Murthy
authors.forename: C K
authors.initials: CK
authors.lastname: Gupta
authors.forename: S K
authors.initials: SK
authors.lastname: Mandal
authors.forename: R
authors.initials: R
authors.lastname: Chandra
authors.forename: A R
authors.initials: AR
authors.lastname: Sircar
authors.forename: J C
authors.initials: JC
authors.lastname: Katiyar
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D002009:Brugia / Q000276:immunology*; D003429:Cross Reactions; D004605:Elephantiasis, Filarial / Q000175:diagnosis*; D005368:Filariasis / Q000175:diagnosis*; D006801:Humans; D007428:Intradermal Tests; D011237:Predictive Value of Tests
chemical_list: D000947:Antigens, Helminth