title: Erythrocyte glucose-6-phosphate dehydrogenase (1.1.1.49) deficiency in Antalya province, Turkey: an epidemiologic and biochemical study.
abstract: Glucose-6-phosphate dehydrogenase (1.1.1.49) activity was assessed in 1986-1988 in blood samples from 1,521 individuals from 375 families living an Antalya city and adjacent villages by Beutler's fluorescence spot test. The families were randomly selected by the State Statistical Institute. Complete deficiency occurred in 7.4% of males and 1.8% of females. Mean enzyme activity was 6.77 +/- 1.07 IU/g Hb in normals and ranged between 0 and 0.48 IU/g Hb in those considered deficient. Kinetic measurements made with partially purified enzyme showed that GdB+ and GdB- variants were present in normal and in deficient subjects, respectively.
authors.affiliation: Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: T A
authors.initials: TA
authors.lastname: Aksu
authors.forename: F
authors.initials: F
authors.lastname: Esen
authors.forename: M S
authors.initials: MS
authors.lastname: Dolunay
authors.forename: Y
authors.initials: Y
authors.lastname: Alicigüzel
authors.forename: G
authors.initials: G
authors.lastname: Yücel
authors.forename: S
authors.initials: S
authors.lastname: Cali
authors.forename: Y
authors.initials: Y
authors.lastname: Baykal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003241:Consanguinity; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006580:Genetic Carrier Screening; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008403:Mass Screening; D014421:Turkey / Q000453:epidemiology
chemical_list: D005954:Glucosephosphate Dehydrogenase