title: The pulmonary manifestations of childhood onset systemic lupus erythematosus.
abstract: Pleuropulmonary disease in childhood onset SLE is common. It may be insidious or present as a life threatening event. North American Indian children in our population appear to be at high risk for severe lung disease. Pulmonary symptoms are present in the majority of children at some time during their disease course and pulmonary function studies are abnormal in the majority of patients. The pulmonary manifestations and frequency of occurrence in childhood appear to be similar to that described in adult onset SLE. Although pulmonary function studies do not correlate well with pulmonary symptoms, these studies provide objective quantification of the type and severity of the functional lesion. Serial tests may be helpful in monitoring disease activity in childhood SLE.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada.
authors.forename: E A
authors.initials: EA
authors.lastname: Delgado
authors.forename: P N
authors.initials: PN
authors.lastname: Malleson
authors.forename: G E
authors.initials: GE
authors.lastname: Pirie
authors.forename: R E
authors.initials: RE
authors.lastname: Petty
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011859:Radiography