[Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process].
Mechanism of the activation of 5-lipoxygenase (EC 1.13.11.12) has been investigated and shown to have the allosteric character. Limitations of the activator structure are formulated.
Butovich
I A
IA
Soloshonok
V A
VA
Solodenko
V A
VA
Kukhar'
V P
VP
D000494:Allosteric Regulation; D001091:Arachidonate Lipoxygenases / Q000037:antagonists & inhibitors*; D002264:Carboxylic Acids / Q000494:pharmacology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013379:Substrate Specificity; D013451:Sulfonic Acids / Q000494:pharmacology*
D002264:Carboxylic Acids; D008041:Linoleic Acids; D016859:Lipoxygenase Inhibitors; D009943:Organophosphorus Compounds; D013451:Sulfonic Acids; D019787:Linoleic Acid; D001091:Arachidonate Lipoxygenases
Aktivatsiia 5-lipoksigenazy lipofil'nymi n-alkilsoderzhashchimi kislotami--allostericheskiĭ protsess.