Rubidium is a possible supporting element for bone marrow leukocyte differentiation.
In the present paper the possible role of rubidium (Rb) on leukocyte differentiation is evaluated. When the metal was added to human mononuclear bone marrow cells cultured for 14 days in soft agar, it was able to increase the number of clusters and to reduce the number of colonies. This activity depended upon the presence of conditioned medium. Rb induced a faster differentiation of HL 60 cells cultured in a medium able to promote granulocyte differentiation. The metal did not show any activity on continuously cultured HL 60. These data suggest that Rb is a supporting element for cell differentiation. Toxicity tests on rats are also reported.
Petrini
M
M
Istituto di Clinica Medica I, Università, Pisa, Italy.
Vaglini
F
F
Carulli
G
G
Azzarà
A
A
Ambrogi
F
F
Grassi
B
B
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D007962:Leukocytes / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured / Q000187:drug effects
D003520:Cyclophosphamide; D012413:Rubidium