Lactate dehydrogenase isoenzymes in squamous cell carcinomas of the oral cavity.
Lactate dehydrogenase (LDH; EC 1.1.1.27) isoenzymes in human epithelial cells from squamous cell carcinomas and healthy tissues of the oral cavity of five patients were analyzed using isoelectric focussing. A new basic isoenzyme and high LDH-7 and LDH-9 activity were found in tumor cells in contrast to epithelial cells of adjoining nontumor tissue. These findings indicate that gradual changes in the percentage distribution of LDH isoenzymes may represent a useful parameter of disease activity in patients with squamous cell carcinomas.
Görögh
T
T
Department of Pathology, University of Kiel, West Germany.
Eickbohm
J E
JE
Ewers
R
R
Lippert
B
B
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000648:ultrastructure
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase