title: [Studies on orocecal transit in diabetes mellitus].
abstract: The present study investigated changes of gastrointestinal transit in diabetes mellitus by a variant of the hydrogen exhalation method, which produces reliable estimates of oro-cecal transit times of a lactulose test meal. Relation to metabolic state and small fibre neuropathy was also evaluated. The latter was indexed by Airaksinen's variability score for resting pulse frequency, Ewing's index of respiratory sinus arrhythmia, and warm and cold thresholds at the foot. 15 inpatients with verified type I diabetes (nine female, six male) and eleven healthy controls (nine female, two male) were under investigation. Ages ranged from 19 to 47 and 27 to 49 years, respectively. No clearcut signs of angiopathy or neuropathy were present in patients. HbA1c values were moderately high (means +/- s = 8.2 +/- 1.6). Diabetes patients showed prolonged transit compared to controls (means +/- s = 102.7 +/- 28.2 min, and 79.6 +/- 15.4, resp.; p = 0.02, U-test). Two patients had extremely long transit times, none showed acceleration. However, neither indices of small fibre neuropathy nor metabolic parameters were significantly correlated with transit measures. Prolonged oro-cecal transit, therefore, seems to be due to a specific visceral-autonomic or primary enteric neuropathy, which is still limited to the gastrointestinal system in this stage, and/or metabolic effects.
authors.affiliation: Max-Planck-Institut für Psychiatrie, Klinisches Institut, München.
authors.forename: S
authors.initials: S
authors.lastname: Lautenbacher
authors.forename: G
authors.initials: G
authors.lastname: Galfe
authors.forename: M
authors.initials: M
authors.lastname: Haslbeck
authors.forename: R
authors.initials: R
authors.lastname: Hölzl
authors.forename: F
authors.initials: F
authors.lastname: Strian
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001944:Breath Tests; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism; D005260:Female; D005772:Gastrointestinal Transit; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
vernacular_title: Untersuchungen zum orozäkalen Transit bei Diabetes mellitus.