A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.
Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.
Watanabe
N
N
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Obuchi
T
T
Tamai
M
M
Araki
H
H
Omura
S
S
Yang
J S
JS
Yu
D Q
DQ
Liang
X T
XT
Huan
J H
JH
D000241:Adenosine / Q000031:analogs & derivatives*; D000363:Agaricales / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D013057:Spectrum Analysis
C063248:6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine; D000241:Adenosine