title: Lymphoscintigraphy and lymphedema of the lower extremities.
abstract: Lymphoscintigraphy, using technetium-99m-labeled sulphur microcolloid, was employed to study the flow and transport of lymph in the lower extremities of 39 consecutive patients in whom lymphedema of one or both legs was suspected clinically. Time-activity curves of four segments of each leg were evaluated for lymph capacity, flow and soft-tissue uptake, and compared with the results from film scintigraphy. Curve analysis provided quantitative evaluation of the extent of hypoplasia or aplasia in primary lymphedema and of lymphatic obstruction in secondary lymphedema, and is particularly suited to assess the involvement of lymphatics in chronic venous disease. Film scintigraphy, on the other hand, is preferable in cases in which the pattern of activity distribution in the affected extremity is diagnostic, such as in dermal back flow, traumatic lymphocele, or megalymphatics. Venography is most informative in cases of suspected underlying venous disease, but the role of lymphangiography, which shows only part of the lymphatic system and requires incision of the edematous tissues, is considered questionable.
authors.affiliation: Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: A M
authors.initials: AM
authors.lastname: Rijke
authors.forename: B Y
authors.initials: BY
authors.lastname: Croft
authors.forename: R A
authors.initials: RA
authors.lastname: Johnson
authors.forename: A B
authors.initials: AB
authors.lastname: de Jongste
authors.forename: J A
authors.initials: JA
authors.lastname: Camps
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D008208:Lymphatic System / Q000503:physiopathology; D008209:Lymphedema / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D061305:Lymphoscintigraphy; D008297:Male; D008875:Middle Aged; D013671:Technetium Tc 99m Sulfur Colloid; D013924:Thrombophlebitis / Q000150:complications; D014001:Tin; D017971:Tin Compounds; D014648:Varicose Veins / Q000150:complications
chemical_list: D017971:Tin Compounds; C037609:technetium Tc 99m tin-sulfur colloid; D013671:Technetium Tc 99m Sulfur Colloid; D014001:Tin