A prospective study in high risk subjects of electrocardiographic changes with ivermectin.
Thirty-two elderly Liberian men, mean age 61 years, were treated with ivermectin and serial electrocardiograms (EKG's) were performed. Twenty of the 32 (62.5%) had baseline EKG abnormalities including poor R wave progression, 1 degrees AV block, non-specific intraventricular conduction abnormalities, left anterior hemiblock, supraventricular premature beats, left axis deviation, and early repolarization. Twelve lead EKG's were done twice daily, pretreatment and on five occasions post-treatment. No significant changes and no new abnormalities were observed. This study fails to demonstrate any significant cardiac effect of ivermectin.
Dukuly
Z D
ZD
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Pacqué
M
M
Nara
A
A
Taylor
H R
HR
Williams
P N
PN
Greene
B M
BM
D000368:Aged; D000369:Aged, 80 and over; D004562:Electrocardiography / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects*; D007988:Liberia; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
D007559:Ivermectin