title: Lipophilicity of some substituted morpholine derivatives synthesized as potential antinociceptive agents.
abstract: Some substituted 2-alkoxy-morpholines have been synthesized as potential antinociceptive agents. These compounds share some structural characteristics of the piperidine analgesics. Their lipophilicity, expressed as log P (octanol-water) and as RM values (from reversed phase thin layer chromatography) was determined. Correlation of these two lipophilicity parameters indicated the classification of the tested compounds into two subgroups. Acute toxicity and, for some selected structures, analgesic activity are reported.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Rekka
authors.forename: S
authors.initials: S
authors.lastname: Retsas
authors.forename: V J
authors.initials: VJ
authors.lastname: Demopoulos
authors.forename: P N
authors.initials: PN
authors.lastname: Kourounakis
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D051379:Mice; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D009025:Morpholines