title: Is the behavioural effect of diazepam in rats unique to negative secondary stimuli?
abstract: Studies of the behavioural effects of benzodiazepines have focused in particular on situations with negative secondary stimuli, i.e., stimuli signalling negative primary events such as punishment or non-reward. The general result is that benzodiazepines attenuate behavioural reactions to this type of stimuli. The aim of the present study was to investigate if there are any differences between positive and negative secondary stimuli in this respect. Rats were treated with diazepam in a modified Skinner box with two levers. One of the levers always gave a small reward. A lamp being ON or OFF was used as a secondary stimulus indicating if the other lever would give a large or no reward. Pretreatment with diazepam (1.0 mg/kg) did not act differently on the response to the positive or negative secondary stimulus. The main effect was a general attenuation of optimal responding with a concomitant decrease in water intake. An alternative hypothesis stating that benzodiazepines alter the reactivity to secondary stimuli more in general is supported.
authors.affiliation: Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Enquist
authors.forename: B
authors.initials: B
authors.lastname: Forkman
authors.forename: T
authors.initials: T
authors.lastname: Ljungberg
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward
chemical_list: D003975:Diazepam