Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia? A preliminary report of buspirone/prolactin responses.
Buspirone stimulates central 5-hydroxytryptamine (5HT) receptors and brings about the release of prolactin, and there is evidence to suggest that the extent of prolactin release after a challenge with buspirone is an indicator of the sensitivity of central 5HT receptors. Seventeen patients with a diagnosis of non-ulcer dyspepsia, eight normal healthy volunteers, and six patients with peptic ulcer disease were each given a challenge test of 60 mg buspirone orally, and prolactin release over a 3-h period was monitored. The mean prolactin response was significantly greater in patients with non-ulcer dyspepsia than in healthy controls and peptic ulcer disease patients. The results suggest that central 5HT receptors may be supersensitive in non-ulcer dyspepsia.
Dinan
T G
TG
Dept of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Republic of Ireland.
Yatham
L N
LN
Barry
S
S
Chua
A
A
Keeling
P W
PW
D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology*; D004415:Dyspepsia / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology*
D011985:Receptors, Serotonin; D012701:Serotonin; D011388:Prolactin; D002065:Buspirone