[The radioprotective properties of the liposomal form of mexamine].
Encapsulation of mexamine (5 methoxytryptamine) in large monostratal lecithin-cholesterol liposomes was shown to cause a 1.4-fold reduction of acute toxicity of the preparation and to prolong its radioprotective efficacy from 15 min to 2 h.
Volchkov
V A
VA
Mikhaĭlova
N Ia
NIa
Rozenberg
O A
OA
Loshakova
L V
LV
Makar'eva
N V
NV
Khanson
K P
KP
D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D003114:Colony-Forming Units Assay; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents; D012701:Serotonin / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008081:Liposomes; D011837:Radiation-Protective Agents; D012701:Serotonin; D008735:5-Methoxytryptamine
Radiozashchitnye svoĭstva liposomnoĭ formy meksamina.