title: Lamins A and C are not expressed at early stages of human lymphocyte differentiation.
abstract: Lamins are major proteins of the nuclear envelope that are members of the intermediate filament protein family. In vertebrates, nuclei from differentiated tissues usually contain both lamins of the A and B subtypes, while embryonic tissues contain the B-type lamin only. We have examined the composition of the nuclear lamina in human B and T lymphocytes representative of distinct stages of lymphoid differentiation. We show here that, in both cell lineages, while lamin B is constitutively expressed at all stages of differentiation, A-type lamin expression is restricted to later developmental stages.
authors.affiliation: Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France.
authors.forename: M N
authors.initials: MN
authors.lastname: Guilly
authors.forename: J P
authors.initials: JP
authors.lastname: Kolb
authors.forename: F
authors.initials: F
authors.lastname: Gosti
authors.forename: F
authors.initials: F
authors.lastname: Godeau
authors.forename: J C
authors.initials: JC
authors.lastname: Courvalin
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000032:analysis* / Q000166:cytology; D002454:Cell Differentiation; D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis; D006801:Humans; D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D013601:T-Lymphocytes / Q000032:analysis* / Q000166:cytology; D014407:Tumor Cells, Cultured
chemical_list: D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins; D012333:RNA, Messenger