title: Topical anaesthesia of gingival mucosa by 5% eutectic mixture of lignocaine and prilocaine or by 10% lignocaine spray.
abstract: The analgesic effect of topical application of local anaesthetics on the gingival mucosa and the absorption of the local anaesthetics into the blood were investigated in healthy volunteers by using a 5% eutectic mixture of the local anaesthetics lignocaine (100 mg) and prilocaine (100 mg) plus emulsifier (EMLA) or 10% lignocaine (200 mg) spray (Xylocain). The pain threshold on labial gingiva was measured by using the stimulator of an EMG-apparatus and a pair of stimulating electrodes, specially constructed for this purpose. There were no differences between the two methods in producing analgesia which was at its maximum in 13 to 14 minutes, on average. Sensation of the gingiva (pain thresholds), had usually returned to normal within 30 minutes. In the dosages used, the absorption of the local anaesthetics was more rapid after the mixture application than after spray application. No toxic reactions occurred.
authors.affiliation: Department of Anaesthesia, Helsinki University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Haasio
authors.forename: T
authors.initials: T
authors.lastname: Jokinen
authors.forename: M
authors.initials: M
authors.lastname: Numminen
authors.forename: P H
authors.initials: PH
authors.lastname: Rosenberg
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005881:Gingiva / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects; D011318:Prilocaine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D011897:Random Allocation; D012684:Sensory Thresholds; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine