title: The case of GISSI in changing the attitudes and practice of Italian cardiologists.
abstract: This report first describes the efficiency achieved by a large scale clinical trial (GISSI), which is widely recognized as having made an important contribution to the therapy of AMI, and second emphasizes how a comprehensive research project based upon an innovative clinical trial methodology can influence the attitude and the scientific productivity of a professional community operating within a national health system. To understand the methodology of GISSI, one must appreciate both the cultural and institutional setting in which the first GISSI trial took place as well as the strong economic and scientific expectation surrounding the second GISSI trial.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Tognoni
authors.forename: M G
authors.initials: MG
authors.lastname: Franzosi
authors.forename: S
authors.initials: S
authors.lastname: Garattini
authors.forename: A
authors.initials: A
authors.lastname: Maggioni
authors.forename: A
authors.initials: A
authors.lastname: Lotto
authors.forename: F
authors.initials: F
authors.lastname: Mauri
authors.forename: F
authors.initials: F
authors.lastname: Rovelli
mesh_terms: D001291:Attitude of Health Personnel; D002309:Cardiology / Q000379:methods*; D003325:Coronary Care Units / Q000458:organization & administration; D006801:Humans; D007558:Italy; D009203:Myocardial Infarction / Q000188:drug therapy; D010865:Pilot Projects; D010818:Practice Patterns, Physicians'; D016032:Randomized Controlled Trials as Topic / Q000191:economics / Q000379:methods*; D013300:Streptokinase / Q000627:therapeutic use
chemical_list: D013300:Streptokinase