Microtransferrinuria and microalbuminuria. I. In the diabetic human.
We studied albumin, transferrin and total protein excretion in the urine of 110 diabetics visiting a family practice department. Of these patients 18.2% had an elevated total urinary protein above the reference range (greater than 200 mg/g creatinine). Of the remaining patients (normoproteinuria), 25.5% have elevated transferrin (greater than 0.9 mg/g creatinine) while 18.8% have elevated albumin (greater than 32 mg/g creatinine). The correlation coefficient between transferrin and albumin in urine when total urinary protein is normal was 0.77. Moderate exercise increased urinary transferrin in normal subjects 950%, while for albumin the increase was 440%. These data demonstrate the usefulness of microtransferrinuria, a potentially more sensitive indicator than microalbuminuria for diabetic nephropathy.
McCormick
C P
CP
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, N.C.
Konen
J C
JC
Shihabi
Z K
ZK
D000419:Albuminuria / Q000652:urine*; D003920:Diabetes Mellitus / Q000652:urine*; D003922:Diabetes Mellitus, Type 1 / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000652:urine; D015444:Exercise; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis; D011507:Proteinuria / Q000652:urine*; D014168:Transferrin / Q000652:urine*
D014168:Transferrin