Microalbuminuria and diabetic complications in Chinese non-insulin-dependent diabetic patients: a prospective study.
Urinary albumin excretion rate (AER) was monitored for periods of up to 3 years and 8 months with an ELISA method in 63 non-insulin-dependent diabetic Chinese subjects and was compared with 50 normal subjects. AER was 3.15 +/- 0.25 micrograms/min (M +/- SE) with a range of 0.27-8.40 micrograms/min for the normal subjects and 7.11 +/- 0.50 (2.11-19.45) micrograms/min for the diabetic subjects. The latter had significantly higher AER (P less than 0.0005). Age, sex, duration of diabetes, HbA1c and BMI did not correlate with AER in the diabetics. The presence of hypertension was found to be accompanied by an accelerated elevation of AER (5.96 +/- 1.58 vs 10.16 +/- 2.17 micrograms/min, at the beginning and at the end of the observation, respectively). Once hypertension became evident, control of blood pressure to a level comparable to that of the non-hypertensive group was not sufficient to halt the deterioration of urinary albumin excretion.
Tai
T Y
TY
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei.
Chuang
L M
LM
Tseng
C H
CH
Wu
H P
HP
Chen
M S
MS
Lin
B J
BJ
D000367:Age Factors; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000652:urine*; D003930:Diabetic Retinopathy / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D013624:Taiwan
D015415:Biomarkers