[Antimetastatic activity of spleen macrophages and T-lymphocytes in mice with transplantable tumors].
The antimetastatic activity (AA) of spleen macrophages and T-lymphocytes of mice bearing four syngeneic tumours were tested in adoptive transfer system. Elimination of phagocytic cells by treatment with carrageenan or by carbonyl iron resulted in a complete (tumours LS, MMT1, MMT-T6I) or partial (MMT-T6I) AA decrease. Spleen macrophages (adherent cells) of tumour-bearers possessed a significant AA. The treatment of spleen cells both by anti-Thy-1-serum and by complement enhanced AA of spleen cells of LS and MMT1 tumour-bearers, but led to a partial AA suppression of spleen cells of MMT-T6I tumour-bearers. Thus, the efficiency of antimetastatic defence may considerably depend on the presence of synergism between macrophages and T-lymphocytes in realization of their AA.
Arkhipov
S A
SA
Iunker
V M
VM
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D054354:Iron Carbonyl Compounds; D008175:Lung Neoplasms / Q000556:secondary; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000276:immunology*; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000494:pharmacology; D010587:Phagocytosis; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D009942:Organometallic Compounds; D054354:Iron Carbonyl Compounds; D002351:Carrageenan
Antimetastaticheskaia aktivnost' makrofagov i T-limfotsitov selezenki mysheĭ s perevivnymi opukholiami.