Studies on medicinal resources from livestock. II. Anti-allergic effects of pig bile. (2).
Anti-allergic activities of lyophilized pig bile [( PB]) were examined in mice with picryl chloride-induced contact dermatitis (PC-CD), an experimental model of delayed-type hypersensitivity (DTH; type-IV allergy). PC-CD was markedly inhibited by an oral administration of [PB] within 4 h after but not during 8 to 16 h after challenge with picryl chloride. Anti-inflammatory activities of [PB] were also examined in acetic acid-induced mouse increased vascular permeability, hypotonic-hyperthermic lysis of rat erythrocytes and carrageenin-induced rat hind paw edema. [PB] had no effect on these models. The present study suggests that [PB] inhibits PC-CD through its immuno-modulation in the inductive phase of DTH rather than by an anti-inflammatory action.
Nakagami
T
T
R & D Center, Nippon Meat Packers Inc., Hyoga, Japan.
Yamasaki
N
N
Taji
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001646:Bile / Q000032:analysis*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D005612:Freeze Drying; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013552:Swine
D000894:Anti-Inflammatory Agents, Non-Steroidal