Local sympathetic reflex control of blood flow in human skin following topical corticosteroid treatment.
Local positional vasomotor activity, or the veno-arteriolar reflex, was studied in normal human skin over 3 days of treatment with a potent corticosteroid under occlusion. Eight healthy subjects participated in the study. Using the atraumatic epicutaneous 133-Xe washout technique on the outer 2 mm of the skin fold between the first and the second finger, and covering the rest of the hand with a lead shield, blood flow in cutaneous tissue only was monitored. The veno-arteriolar reflex was elicited by inducing venous stasis. Before treatment, 40 mmHg venous stasis reduced cutaneous blood flow by 37.1% (95 percentile, 24.5-56.0). Following 24 h and 48 h of treatment, the reflex became weaker and at day 3, the blood flow reduction was 17.8% (7.6-42.6). The diminution was significant (p less than 0.05).
Petersen
L J
LJ
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Kristensen
J K
JK
D001160:Arterioles / Q000294:innervation; D001623:Betamethasone / Q000031:analogs & derivatives*; D001783:Blood Flow Velocity / Q000187:drug effects; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D012018:Reflex / Q000502:physiology*; D012867:Skin / Q000098:blood supply*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014680:Veins / Q000294:innervation; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D001623:Betamethasone; D002990:Clobetasol