title: Morphine, morphine-6-glucuronide and morphine-3-glucuronide concentrations in plasma and cerebrospinal fluid during long-term high-dose intrathecal morphine administration.
abstract: The kinetics of morphine, morphine-6-glucuronide (M6G), and morphine-3-glucuronide (M3G) were studied in a 56-year-old female with lung cancer. Long-term treatment with morphine intrathecally 28 mg every 6 h was used for pain control. Cerebrospinal fluid (CSF) concentrations of morphine were high with an elimination half-life of 2.1 h. The plasma/CSF ratios for M6G and M3G were 1:0.8 and 4:1, respectively, suggesting that M6G penetrates the blood-brain barrier more easily than M3G. The low CSF concentrations indicate that M6G played hardly any major analgetic role in the patient studied.
authors.affiliation: Pain Clinic, Bispebjerg Hospital, CopenhagenDenmark Department of Pharmacology, University of Copenhagen, CopenhagenDenmark.
authors.forename: D
authors.initials: D
authors.lastname: Bigler
authors.forename: Broen C
authors.initials: BC
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Eriksen
authors.forename: H N
authors.initials: HN
authors.lastname: Jensen
mesh_terms: D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008875:Middle Aged; D009020:Morphine / Q000097:blood* / Q000134:cerebrospinal fluid; D009022:Morphine Derivatives / Q000097:blood* / Q000134:cerebrospinal fluid; D009994:Osmolar Concentration; D013997:Time Factors
chemical_list: D009022:Morphine Derivatives; C035349:morphine-6-glucuronide; D009020:Morphine; C018108:morphine-3-glucuronide