[The modifying action of the Japanese pagoda tree (Sophora japonica) and pantocrine in radiation lesions].
A study was made of the effect of Sophora japonica and pantocrine on irradiated (2.5 Gy) human lymphoblastoid cells. The radioprotective effect was manifested with the preparations injected separately after irradiation. The highest radioprotective effect was produced by the mixture of the preparations, the injection 15 min after irradiation being more effective than preinjection. The protective effect of the agents was studied on mongrel mice after the administration thereof for the purposes of protection protection-and-treatment and treatment. Sophora japonica and pantocrine were shown to increase the survival rate of lethally exposed mice (LD90/30) when administered in a combination 5-15 min before irradiation and when used for the purposes of protection--and--treatment: 53.3% and 50% of animals, respectively, survived by day 30 following irradiation. DMF was 1.25.
Narimanov
A A
AA
Kuznetsova
S M
SM
Miakisheva
S N
SN
D000818:Animals; D000999:Antlers; D002478:Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D014197:Trees
D010936:Plant Extracts
Modifitsiruiushchee deĭstvie sofory iaponskoĭ (Sophora japonica) i pantokrina pri luchevom porazhenii.