[Experimental studies of the so-called emulsification behavior of silicone oil: effect of viscosity].
The stability of intraocularly applied silicone oils plays an important role in their biocompatibility. The clinically used silicone oils are not a unique group of materials. There are important differences regarding viscosity and the amount of low molecular and ionic components. A sign of bioinstability of silicone oils is silicone oil emulsification. According to clinical experience and experimental studies, less viscous silicone oils seem to emulsify earlier then more viscous oils. Therefore, we investigated three highly purified polydimethylsiloxanes with defined physicochemical characteristics and viscosities of 1,000 cs, 5,000 cs and 10,000 cs for their in vitro stability. As detergents, we used fibrin, fibrinogen, gammaglobulins, acidic alpha-1-glycoprotein, very-low-density lipoprotein (VLDL), and serum. The oil with a viscosity of 1000 cs was the most unstable silicone oil whereas the oils of 5,000 cs and 10,000 cs reacted similarly. The most effective detergents were fibrin, fibrinogen and serum-causing emulsification for all silicone oils investigated whereas gamma-globulins, acidic alpha-1-glycoprotein and VLDL only emulsified the less viscous oil of 1,000 cs. Our results show the importance of viscosity for the stability of silicone oils and the effect of biologically potential detergents.
Heidenkummer
H P
HP
Universität-Augenklinik, Würzburg.
Kampik
A
A
Thierfelder
S
S
D004355:Drug Stability; D005079:Excipients; D006801:Humans; D012827:Silicone Oils / Q000009:adverse effects / Q000032:analysis*; D014783:Viscosity; D014821:Vitrectomy
D005079:Excipients; D012827:Silicone Oils
Experimentelle Untersuchungen zum sogenannten Emulsifikationsverhalten von Silikonöl: Einfluss der Viskosität.