title: Dual-energy x-ray absorptiometry: a precise method of measuring bone mineral density in the lumbar spine.
abstract: We compared two methods of measuring spinal bone mineral content and density (BMC/BMD): conventional dual-photon absorptiometry (DPA) and a more recent method, dual-energy x-ray absorptiometry (DEXA). The clinical usefulness of both methods was compared in the measurement of BMC in the forearm. DEXA had a long-term in vivo precision of 1% which was significantly better than that of DPA. Changes in the distribution of fatty tissue influenced the accuracy of the two spinal methods in different ways. Forearm BMC discriminated between the bone mass of early and late postmenopausal women to the same degree as DPA and DEXA. The variability in the response to estrogen treatment and placebo was much lower with DEXA and forearm BMC than with DPA. We conclude that DEXA provides a fast and precise measurement of spinal BMC/BMD. The accuracy remains to be evaluated for in vivo studies.
authors.affiliation: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: M A
authors.initials: MA
authors.lastname: Hansen
authors.forename: C
authors.initials: C
authors.lastname: Hassager
authors.forename: K
authors.initials: K
authors.lastname: Overgaard
authors.forename: U
authors.initials: U
authors.lastname: Marslew
authors.forename: B J
authors.initials: BJ
authors.lastname: Riis
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods* / Q000592:standards; D000273:Adipose Tissue; D015519:Bone Density; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008961:Models, Structural; D011877:Radionuclide Imaging; D011884:Radius / Q000000981:diagnostic imaging; D014457:Ulna / Q000000981:diagnostic imaging