Gentamicin induced dose related alterations in lipid levels and lipid peroxidation in central auditory pathway of the rat.
A study was carried out on the effect of gentamicin on the central auditory pathway in rats. Rats were administered graded doses of gentamicin (60 mg, 100 mg and 160 mg/kg b.wt., i.m.) daily for 21 days. Levels of total lipids, phospholipids and cholesterol showed dose related increment in the central auditory pathway. On the other hand, the rate of lipid peroxidation was inhibited in all regions of the central auditory pathway of the rat.
Aslam
M
M
Department of Anatomy, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
Raza
M H
MH
Khan
N A
NA
Hasan
M
M
Hasan
S A
SA
Ullah
M
M
D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000633:toxicity*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats
D005839:Gentamicins