Effect of ethambutol on the phospholipids of ethambutol susceptible and resistant strains of Mycobacterium smegmatis ATCC 607.
Effect of ethambutol (EMB) on phospholipid composition and metabolism of EMB-susceptible and EMB-resistant strains of M. smegmatis ATCC 607 was studied. Treatment with ethambutol had different effect in both the strains resulting in decreased total phospholipid and cardiolipin content in EMB-susceptible strain and increased content in EMB-resistant strain, with no effect on fatty acyl group composition. These changes were further corroborated by the use of [1-14C]sodium acetate in these studies.
Sareen
M
M
Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh.
Khuller
G K
GK
D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*
D010743:Phospholipids; D004977:Ethambutol