title: Exacerbation of chronic obstructive pulmonary disease due to hyperinfection with Strongyloides stercoralis.
abstract: Pulmonary infection due to the filariform larvae of Strongloides stercoralis may occur in immunocompromised patients residing in endemic areas of the United States. Such infection usually presents as dyspnea with a cough that sometimes results in bloody sputum. Although the chest roentgenogram often reveals a patchy bilateral alveolar infiltrate, acute respiratory distress is unusual. We report a patient who experienced severe exacerbation of his underlying obstructive lung disease that was associated with chest infiltrates and recovery of S stercoralis from his sputum. Although initial improvement was accomplished with Thiobendazole treatment, a re-exacerbation occurred when antiparasitic therapy was completed. The persistence of his infection is correlated to factors that are commonly employed in the treatment of COPD but may be overlooked as predisposing causes of hyperinfection with S stercoralis.
authors.affiliation: Department of Respiratory and Environmental Medicine, University of Louisville School of Medicine, Kentucky 40292.
authors.forename: M A
authors.initials: MA
authors.lastname: Ossorio
authors.forename: P E
authors.initials: PE
authors.lastname: Brown
authors.forename: C L
authors.initials: CL
authors.lastname: Fields
authors.forename: T M
authors.initials: TM
authors.lastname: Roy
mesh_terms: D000818:Animals; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000469:parasitology; D013321:Strongyloides / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000469:parasitology; D015163:Superinfection