Protection against carbon-tetrachloride-induced lymphoid organotoxicity in rats by protein A.
In a previous study we described protection of rats from carbon tetrachloride (CCl4)-induced hepatotoxicity by protein A (PA). In the present report we described protection against CCl4-induced lymphoid organotoxicity in rats by PA. Our data indicate that CCl4 administration produced a significant increase in the number of total leukocytes and polymorphs in blood, a significant decrease in leukocyte count in bone marrow, and a significant loss in weight of spleen and adrenals. In the animals receiving PA prior to and after CCl4, these values were found to be near those of controls. Histological examination revealed thymocyte depletion in thymic lobe and degenerative changes of tissue in spleen of CCl4-exposed animals. PA treatment to CCl4-exposed animals exhibited improvement and recovery from the damage caused by CCl4. These observations throw a new light on the field of CCl4 toxicity to lymphoid organs and their protection by PA.
Singh
K P
KP
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Zaidi
S I
SI
Raisuddin
Saxena
A K
AK
Dwivedi
P D
PD
Seth
P K
PK
Ray
P K
PK
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D004336:Drug Antagonism; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013205:Staphylococcal Protein A / Q000008:administration & dosage / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D013205:Staphylococcal Protein A; D002251:Carbon Tetrachloride