Transdermal delivery of theophylline to premature infants using a hydrogel disc system.
1. Preterm infants show incompletely developed skin with reduced barrier function. The possibility of transdermal delivery of theophylline from hydrogel discs swollen with choline theophyllinate has been investigated. 2. Drug loaded hydrogel discs 2 cm2 in area were applied to the abdomen and occluded. Serum theophylline concentrations were measured in twenty-one infants of less than 31 weeks gestation. 3. Therapeutic concentrations were achieved in 18 individuals, and maintained for up to 15 days after repeated application of discs. A correlation between maximum serum drug concentration and transepidermal water loss, gestation and birthweight was demonstrated.
Cartwright
R G
RG
Department of Pharmaceutical Sciences, University of Nottingham.
Cartlidge
P H
PH
Rutter
N
N
Melia
C D
CD
Davis
S S
SS
D000279:Administration, Cutaneous; D002794:Choline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D013806:Theophylline / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology
C012839:cholinophyllin; D013806:Theophylline; D002794:Choline