[Methodology of clinical studies of myorelaxants].
Myorelaxants, a specific pharmacologic group, are often prescribed. However, for many molecules, therapeutic trial methodology is not adapted. A review of the fundamental aspects of pharmacological trial clearly show a need for diagnosis and inclusion criteria, definition and validation for methods of assessment, analysis of the dose-response curve on term of effectiveness according to the pharmacologic and clinically established rules. Rational prescription of myorelaxants will arise from this principles.
Blin
O
O
Système Nerveux et de l'Appareil Locomoteur, CHU Timone, Marseille.
Guieu
R
R
Desnuelle
C
C
Serratrice
G
G
D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D013673:Technology Assessment, Biomedical
D009125:Muscle Relaxants, Central
Méthodologie des études cliniques des myorelaxants.