Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antimalarial activity in mice.
The petroleum either extract and methanol extract of the bark of Alstonia scholaris were found to be devoid of antiamalarial activity in mice infected with Plasmodium berghei. However, a dose-dependent improvement of conditions and delayed mortality amongst animals receiving methanol extract of A. scholaris was noticed. Studies with A. constricta and alstonine shall help resolve the antimalarial status of the bark in question.
Gandhi
M
M
Department of Experimental Medicine, Postgraduate Institute of Medicinal Education and Research, Chandigarh, India.
Vinayak
V K
VK
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000627:therapeutic use*
D000962:Antimalarials; D010936:Plant Extracts