title: Cytogenetic analysis of murine embryo-derived tumors.
abstract: The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 18 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6, 15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.
authors.affiliation: Department of Pathology, University of Groningen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: van Berlo
authors.forename: B
authors.initials: B
authors.lastname: de Jong
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: J
authors.initials: J
authors.lastname: Buist
authors.forename: A
authors.initials: A
authors.lastname: Dam
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D007621:Karyotyping; D008297:Male; D008649:Mesonephroma / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D011003:Ploidies; D013724:Teratoma / Q000235:genetics*