[Antineoplastic and immunostimulating effects of several N-vinylpyrrolidone co(ter)polymers in C3HA strain mice with hepatoma 22a].
The antitumor and immunoadjuvant action of water-soluble N-vinylpyrrolidone co(ter)polymers of different chemical structure is studied. It is established that terpolymer N-vinyl-pyrrolidone (VP)--crotonic acid (CA)--n-crotonoylaminophenol inhibiting the growth of hepatoma 22a by 50-60% possesses an antitumoral action, while copolymer VP-CA has an immunoadjuvant action. These properties of co(ter)polymers are due to their chemical structure and molecular weight, but they do not always correlate between themselves.
Korosteleva
T A
TA
Movsesian
K S
KS
Solovskiĭ
M V
MV
Panarin
E F
EF
Nazarova
O V
OV
Kochetkova
I S
IS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003437:Crotonates / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D011108:Polymers; D011760:Pyrrolidinones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D003437:Crotonates; D011108:Polymers; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone
Protivoopukholevoe i immunostimuliruiushchee deĭstvie nekotorykh co(ter)polimerov N-vinilpirrolidona na mysheĭ linii C3HA s gepatomoĭ 22a.