title: Do thermoregulatory reflexes pass through the hypothalamus? Studies of chronic hypothermia due to hypothalamic lesion.
abstract: A 38-year-old man presented with chronic hypothermia. He also had evidence of hypothalamo-pituitary dysfunction and CT scans showed a discrete hypothalamic lesion. Thermoregulatory impairment was found although there was normal circulatory control of blood pressure. Reflex vasodilatation could be initiated when hypothermia was present and also in response to raised body temperature. Shivering was initiated reflexly but did not otherwise occur. These observations imply that thermoregulatory reflexes are independent of central thermoregulatory mechanisms and do not pass through the hypothalamus.
authors.affiliation: John Radcliffe Hospital, Oxford, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Johnson
authors.forename: J W
authors.initials: JW
authors.lastname: Delahunt
authors.forename: B J
authors.initials: BJ
authors.lastname: Robinson
mesh_terms: D000328:Adult; D001833:Body Temperature Regulation / Q000502:physiology*; D002908:Chronic Disease; D006358:Hot Temperature / Q000627:therapeutic use; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000503:physiopathology; D007035:Hypothermia / Q000209:etiology* / Q000628:therapy; D008297:Male; D014057:Tomography, X-Ray Computed