[Adaptation to short-term stressor factors increases calcium pump activity in sarcoplasmic reticulum and decreases the rate of its inactivation during autolysis].
Effects of long-term immobilization stress and adaptation to short-term stressory actions on Ca2(+)-transport system were studied in sarcoplasmic reticulum (SR) of rat myocardium. The stress inhibited the rate of Ca2+ transport in SR, while adaptation not only optimized the Ca2(+)-pump functions but prevented the stress-induced impairments of its functions. After stress resistance of Ca2(+)-pump to endogenous impairing factors (in autolysis) was decreased 2-3-fold, whereas adaptation increased the SR membrane stability so distinctly that after simultaneous stress the membrane stability was maintained at the level which-was 2.5-times higher as compared with controls. Long-term stress caused also the higher output of Ca+2 from intracellular stores as compared with controls, while during adaptation and simultaneous stress and adaptation the loss of Ca2+ was practically absent. Protective effects of adaptation to short-term stressory actions on the Ca2(+)-transport system of cardiomyocytes are discussed.
Meerson
F Z
FZ
Sazontova
T G
TG
Arkhipenko
Iu V
IuV
D000222:Adaptation, Physiological; D000818:Animals; D001329:Autolysis; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
D002118:Calcium
Adaptatsiia k kratkovremennym stressornym vozdeĭstviiam uvelichivaet aktivnost' kal'tsievogo nasosa sarkoplazmaticheskogo retikuluma i snizhaet skorost' ego inaktivatsii pri avtolize.