title: Pregnancy outcome of patients with uncorrected uterine anomalies managed in a high-risk obstetric setting.
abstract: During an 8-year period, we managed 42 women with 101 pregnancies with previously diagnosed but uncorrected uterine malformations referred to our institution for high-risk obstetric care. All patients were managed under the same standardized protocol requiring weekly visits and decreased physical activity. The population studied consisted of four groups of pregnancies with the following uterine anomalies: unicornuate (five), bicornuate (61), septate (25), and didelphys (ten). Sixty percent of the pregnancies in the unicornuate and didelphys group reached term, 39% in the bicornuate group, and 48% in the septate group. Preterm labor requiring tocolysis occurred in 21% of the pregnancies in the bicornuate group and 15% of the pregnancies in the septate group. Cerclage was placed in 5% of the pregnancies in the bicornuate group. Before our care, the fetal survival rate for pregnancies in the bicornuate and septate groups was 52 and 53%, respectively; with our management protocol, it was 58 and 65%, differences that were not statistically significant. Our experience suggests that high-risk obstetric intervention does not obviate the potential benefit of metroplasty, especially for patients with a bicornuate or septate uterus. We believe that traditional indications for metroplasty should continue to be used.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia.
authors.forename: J
authors.initials: J
authors.lastname: Ludmir
authors.forename: P
authors.initials: P
authors.lastname: Samuels
authors.forename: S
authors.initials: S
authors.lastname: Brooks
authors.forename: M T
authors.initials: MT
authors.lastname: Mennuti
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D036861:Delivery, Obstetric; D005260:Female; D005313:Fetal Death; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D014599:Uterus / Q000002:abnormalities*