title: Isochromosome 7q as the sole abnormality in an unusual case of T-cell lineage malignancy.
abstract: We present a case of large cell lymphoma in a 20-year-old Oriental male who presented with massive splenomegaly and mild anemia. Surface marker and molecular genetic analyses of lymphomatous cells obtained from the spleen indicated a T-cell origin. Chromosomal analysis identified an isochromosome 7q as the sole abnormality. This is the first report of isochromosome 7q as the sole cytogenetic abnormality in a T-lineage malignant clonal expansion.
authors.affiliation: University of Toronto Hospitals Cancer Cytogenetics Program, Toronto General Hospital, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Colwill
authors.forename: I
authors.initials: I
authors.lastname: Dubé
authors.forename: J G
authors.initials: JG
authors.lastname: Scott
authors.forename: D
authors.initials: D
authors.lastname: Bailey
authors.forename: E
authors.initials: E
authors.lastname: Deharven
authors.forename: K
authors.initials: K
authors.lastname: Carstairs
authors.forename: D
authors.initials: D
authors.lastname: Pantalony
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015139:Blotting, Southern; D002869:Chromosome Aberrations / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D013601:T-Lymphocytes
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte