title: [1,2-dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice].
abstract: The results of experiments on the 1,2-dimethylhydrazine (DMH) induction of epithelial renal tumours in CBA male mice are presented. The dose-response study shows a sharp increase (from 5 to 75%) of the epithelial renal tumour incidence in the range of 2, 4 and 8 injections of DMH. Higher doses induce a decrease of the tumour incidence due to the early death caused by other tumours. DMH is shown to be the most powerful renal carcinogen in mice. Serial sacrifice of mice after 5 injections of DMH is a convenient model for the study of renal carcinogenesis in mice. Main histological types of epithelial renal tumours are illustrated.
authors.forename: V S
authors.initials: VS
authors.lastname: Turusov
authors.forename: N S
authors.initials: NS
authors.lastname: Lanko
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Parfenov
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Chemeris
mesh_terms: D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D003536:Cystadenocarcinoma / Q000139:chemically induced / Q000473:pathology; D004127:Dimethylhydrazines; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008763:Methylhydrazines; D051379:Mice; D008808:Mice, Inbred CBA
chemical_list: D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine
vernacular_title: Induktsiia 1,2-dimetilgidrazinom épitelial'nykh opukholeĭ pochek u mysheĭ linii CBA.