Structural studies on new depsipeptide antibiotics, variapeptin and citropeptin.
Variapeptin and citropeptin were found as novel hexadepsipeptide antibiotics produced by Streptomyces variabilis and Streptomyces flavidovirens, respectively. Their structures were elucidated by NMR spectral analysis including a variety of 2D techniques. Variapeptin and citropeptin are structurally realted to azinothricin and A83586C, respectively.
Nakagawa
M
M
Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Hayakawa
Y
Y
Furihata
K
K
Seto
H
H
D000900:Anti-Bacterial Agents / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides; D010456:Peptides, Cyclic / Q000032:analysis; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; C064643:variapeptin; C064644:citropeptin