[The prevention and treatment of experimental radiation injuries to the skin by using the Nucliderm-gel preparation].
Radiopreventive and radiotherapeutic efficacy of nuclyderm-gel was studied on tails of mice exposed to fractionated gamma-radiation of 90 Gy (15 + 30 + 45 Gy) and 75 Gy (45 + 30 Gy). Daily seven-day treatment with nuclyderm-gel prior to irradiation with increasing doses (15 + 30 + 45 Gy) and the subsequent continuous therapy were shown to delay and reduce skin reactions. Nuclyderm-gel was particularly effective when used therapeutically. The treatment of exposed areas, with the three-fold dose fractionation, was the optimum therapy scheme.
Stefanova
D
D
Grashev
G
G
Marinova
Ts
Ts
Pantev
T
T
D000279:Administration, Cutaneous; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D005782:Gels; D008297:Male; D051379:Mice; D011119:Polynucleotides / Q000627:therapeutic use*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011855:Radiodermatitis / Q000188:drug therapy / Q000517:prevention & control*; D013997:Time Factors
D005782:Gels; D011119:Polynucleotides; D011837:Radiation-Protective Agents
Profilaktika i lehcenie éksperimental;'nykh luchevykh povrezhdeniĭ kozhi s pomoshch'iu preparata nukliderm-gel'.