First report of chronic meningitis caused by Trichosporon beigelii.
Trichosporon beigelii (Trichosporon cutaneum) was identified as the causative agent of chronic meningitis in a 15-year-old boy with acute lymphocytic leukaemia. After a neutropenic episode following cytostatic treatment and itraconazole therapy as prophylaxis, cerebrospinal fluid (CSF) samples yielded growth of Trichosporon beigelii. Treatment with amphotericin B, flucytosine and high doses of fluconazole was followed by clinical improvement, although CSF pleocytosis remained. The cross-reactivity between Cryptococcus neoformans and Trichosporon beigelii in a cryptococcal antigen latex test was used as a means of diagnosis in CSF and serum samples.
Surmont
I
I
Department of Microbiology, St. Rafael University Hospital, Leuven, Belgium.
Vergauwen
B
B
Marcelis
L
L
Verbist
L
L
Verhoef
G
G
Boogaerts
M
M
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000008:administration & dosage; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D009181:Mycoses / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D009894:Opportunistic Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D014250:Trichosporon / Q000472:pathogenicity
D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine