[Xanthine oxidase activity of thymocytes in lymphocytolytic effect of hypoxanthine].
Destruction of thymocytes, caused by incubation with hypoxanthine, was decreased distinctly after addition of allopurinol as shown by eosin staining. Lymphocytolytic effect of hypoxanthine was accompanied by considerable activation in thymocytes of endogenous xanthine oxidase, which was measured by superoxide anion production; allopurinol decreased the enzyme activity. Enzymatic activity of nucleases participating in degradation of chromatin appears to be a component of prooxidant enzymatic systems of cell.
Kozhemiakin
L A
LA
Shelepina
E P
EP
Antonov
V G
VG
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005609:Free Radicals; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism / Q000633:toxicity*; D007399:Interphase; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D014969:Xanthine Oxidase / Q000378:metabolism*
D005609:Free Radicals; D007042:Hypoxanthines; D019271:Hypoxanthine; D000493:Allopurinol; D014969:Xanthine Oxidase
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