The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice.
The effects of endotoxin on mouse liver phospholipid fatty acid composition have been investigated. Administration of endotoxin from Salmonella abortus equi led to a decrease in the polyunsaturated fatty acid content of livers from mice sensitized with Bacille Calmette Guérin (BCG). The content of arachidonic acid fell significantly in both the phosphatidylcholine and phosphatidylinositol fractions whereas in the phosphatidylethanolamine fraction the linoleic acid content was significantly reduced. The polyunsaturated fatty acids were replaced by increased amounts of oleic acid and palmitic acid, leading to a reduction in the polyunsaturated to saturated fatty acid ratio.
Stark
J M
JM
Department of Medical Microbiology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom.
Jackson
S K
SK
Taylor
S
S
Davies
I
I
Harwood
J L
JL
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001500:BCG Vaccine; D002462:Cell Membrane / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D007114:Immunization; D008099:Liver / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010743:Phospholipids / Q000378:metabolism; D012475:Salmonella
D001095:Arachidonic Acids; D001500:BCG Vaccine; D004731:Endotoxins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010743:Phospholipids