Treatment of large lower genital tract condylomata acuminata with topical 5-fluorouracil.
Nineteen women with extensive condyloma acuminatum involvement of the lower female genital tract were treated with seven-day courses of topical 5-fluorouracil. The complete response rate was 68.4%. One patient completed only two courses; she underwent vaginal delivery after cryosurgical destruction of the remaining lesions. Her recurrent lesions in the immediate postpartum period were controlled with additional courses of topical 5-fluorouracil. Only one patient was totally unresponsive to treatment with topical 5-fluorouracil.
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Gynecologic Oncology Section, Texas Tech University Health Sciences Center, Odessa.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy; D011644:Puerperal Disorders / Q000188:drug therapy
D005472:Fluorouracil