Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus.
The three intramolecular disulfide linkages of geographutoxin I, a peptide neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986-1994]. The disulfide bridges were found to be between Cys3 and Cys15, Cys4 and Cys20, and Cys21, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.
Hidaka
Y
Y
Institute for Protein Research, Osaka University, Japan.
Sato
K
K
Nakamura
H
H
Kobayashi
J
J
Ohizumi
Y
Y
Shimonishi
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004220:Disulfides / Q000032:analysis; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D008978:Mollusk Venoms; D009498:Neurotoxins; D010455:Peptides / Q000138:chemical synthesis* / Q000302:isolation & purification; D010456:Peptides, Cyclic; D011487:Protein Conformation; D012908:Snails
D004220:Disulfides; D008978:Mollusk Venoms; D009498:Neurotoxins; D010455:Peptides; D010456:Peptides, Cyclic; C038093:geographutoxin I