title: Glutathione enhancement in various mouse organs and protection by glutathione isopropyl ester against liver injury.
abstract: Intraperitoneal administration of glutathione isopropyl ester to fasted, male NMRI mice dose dependently increased the glutathione concentration in various organs. Administration of 1 g/kg glutathione isopropyl ester led to the following increases: liver 166%; lung 164%; heart 121% after 4 hr; and brain 133% after 6 hr. Spleen, kidney, muscle, serum and blood cell glutathione were not affected by the treatment. Pretreatment with glutathione isopropyl ester was found to protect against paracetamol- or allyl alcohol-induced liver damage. Following treatment with the ester a significant correlation between protection against liver damage and enhancement of liver glutathione content was obtained. The dose dependence of this protection was studied.
authors.affiliation: Faculty of Biology, University of Konstanz, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Uhlig
authors.forename: A
authors.initials: A
authors.lastname: Wendel
mesh_terms: D000433:1-Propanol / Q000037:antagonists & inhibitors / Q000633:toxicity; D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D005215:Fasting; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D020005:Propanols; D014018:Tissue Distribution
chemical_list: D020005:Propanols; D000082:Acetaminophen; C006463:allyl alcohol; D000433:1-Propanol; C058293:glutathione monoisopropyl ester; D005978:Glutathione