Phthalocyanine fluorescence in tumors during PDT.
Athymic nude mice with human tumors transplanted to one of the hind legs were given aluminium phthalocyanine disulfonate (AlPcS2) intraperitoneally. Twenty-four hours after the injection the mice were placed with the tumor in the sample position in a fluorescence spectrometer with modulated excitation. Exposure of the tumors to laser light at a fluence rate of 50-200 mW/cm2 led to a rapid transient reduction by up to 50% of the phthalocyanine fluorescence of the tumor. After the laser irradiation the fluence rate of the fluorescence increased almost up to the initial value within a few minutes. This finding should be taken into account when optimal fluence rates and dose fractionation schemes are sought for photodynamic therapy.
Moan
J
J
Institute for Cancer Research, Oslo, Norway.
Anholt
H
H
D000818:Animals; D002460:Cell Line; D005260:Female; D006801:Humans; D007211:Indoles / Q000032:analysis* / Q000627:therapeutic use*; D054833:Isoindoles; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010778:Photochemotherapy; D010860:Pigments, Biological / Q000032:analysis*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013050:Spectrometry, Fluorescence; D014183:Transplantation, Heterologous
D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D010860:Pigments, Biological; D011838:Radiation-Sensitizing Agents; C064331:aluminum phthalocyanine disulfonate; C013647:phthalocyanine