Epidermal growth factor receptor expression in demented and aged human brain.
Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of 13/13 demented elderly patients, but absent in 9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells.
Styren
S D
SD
Department of Zoology, Arizona State University, Tempe 85287.
Mufson
E J
EJ
Styren
G C
GC
Civin
W H
WH
Rogers
J
J
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000098:blood supply / Q000254:growth & development* / Q000473:pathology; D003704:Dementia / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D066246:ErbB Receptors