[Reversible cardiogenic shock due to 5FU. Apropos of a case report].
The authors report the case of a man with a laryngeal neoplasm treated by chemotherapy including 5 FU who presented a severe cardiogenic shock responding to medical therapy with a favourable outcome. This classical clinical presentation is commented by the authors. Based on the electrocardiogram, the echocardiography and a review of literature, they favour as first underlying hypothesis the secondary metabolic pathway linked to ribonucleic acid (RNA), rather than a possible coronary spasm.
Dieudonne
P
P
Service de Médecine interne, Hôpital Erasme, Bruxelles, Beloeil.
Dumont
M A
MA
D000230:Adenocarcinoma / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000188:drug therapy
D002317:Cardiovascular Agents; D005472:Fluorouracil
Choc cardiogénique reversible dû au 5 FU. A propos d'une observation.