[Atranes: their ulcerostatic effect and its possible mechanisms].
The ulcerostatic activity of methylethyl (sylathrane-1-ilmethyl) sulfoiodide, 1-(chlormethyl) sylatrane, and 1-(isopropoxy)hermatrane has been revealed at experimental acetate ulcer in rats. The effect of atranes was equal to that of oxyferriscorbone and exceeded that of methyluracil. All the compounds studied inhibited peroxide oxidation of lipids in blood and stomach tissues from ulcer and in model experiments in egg yolk liposomes. The processes of ulcer development and photodynamic effects of lipid peroxidation in biological objects have been summarized. The data obtained allow to conclude that the ulcerostatic mechanism of action effect of atranes and the comparable drugs is based on their antioxidative effect.
Kuznetsov
I G
IG
Rasulov
M M
MM
Voronkov
M G
MG
D000085:Acetates; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009570:Nitriles / Q000494:pharmacology / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use; D017646:Organosilicon Compounds; D051381:Rats; D012825:Silicon / Q000494:pharmacology / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D013452:Sulfonium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
D000085:Acetates; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D009570:Nitriles; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D013452:Sulfonium Compounds; C015503:silatrane; C060353:isopropoxygermatrane; C058763:methylethyl(silatrane-1-ylmethyl)sulfonium; C033818:1-(chloromethyl)silatrane; D012825:Silicon
Atrany: ul'tserogstaticheskiĭéffekt i ego vozmozhnye mekhanizmy.