Interleukin-1 production by immunologically hyporeactive tumour-bearing mice.
Mice bearing progressively growing syngeneic methylcholanthrene-induced sarcomas are immunologically hyporeactive. However, both basal (steady-state) and bacterial lipopolysaccharide (LPS)-induced synthesis of mRNA for interleukin-1 (IL-1) in peritoneal exudate cells (PEC) or spleen cells were comparable in control and tumour-bearing animals. Furthermore, the production of IL-1 by PEC stimulated with LPS in the presence of indomethacin was same in control and tumour-bearing mice. The results thus demonstrate that LPS-stimulated cells from animals bearing progressively growing syngeneic sarcomas synthesise the same quantities of mRNA for IL-1 and produce comparable amounts of IL-1 as do cells from normal animals, in spite of the profound immunological hyporeactivity of the former.
Holán
V
V
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
Lipoldová
M
M
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism / Q000473:pathology; D007108:Immune Tolerance; D007375:Interleukin-1 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012513:Sarcoma, Experimental / Q000276:immunology / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000378:metabolism
D007375:Interleukin-1; D012333:RNA, Messenger; D012334:RNA, Neoplasm