Association of primary sclerosing cholangitis with HLA-DRw52a.
We sought to determine whether there are specific HLA haplotypes in patients with either primary sclerosing cholangitis or primary biliary cirrhosis. Surprisingly, 100 percent of the 29 patients with primary sclerosing cholangitis had the HLA-DRw52a antigen, which is normally present in 35 percent of the population (relative risk, 109.5; P less than 0.00001). Fifteen of these patients had a single common haplotype: A1,B8,Cw7,DRw17,DQw2,DRw52a. In the remaining 17 patients there was a loss of at least one of these antigens. Of the 15 patients with the common haplotype, 12 also had ulcerative colitis, thereby linking the occurrence of ulcerative colitis in patients with primary sclerosing cholangitis to the presence of this haplotype. Although there was no association in 35 patients between primary biliary cirrhosis and specific HLA haplotypes, there was a significant association of the disease with DRw8 (relative risk, 3.1; P = 0.02). We conclude that the development of primary sclerosing cholangitis involves a strong genetic predisposition. Since the association of primary sclerosing cholangitis with HLA-DRw52a appears to be total, HLA typing should be helpful in differentiating this disease from primary biliary cirrhosis.
Prochazka
E J
EJ
Department of Surgery, UCLA School of Medicine.
Terasaki
P I
PI
Park
M S
MS
Goldstein
L I
LI
Busuttil
R W
RW
D015209:Cholangitis, Sclerosing / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics; D008040:Genetic Linkage; D006684:HLA-DR Antigens / Q000032:analysis; D059810:HLA-DR Serological Subtypes; D006239:Haplotypes; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000235:genetics; D012307:Risk Factors
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C051104:HLA-DR52 antigen; C041559:HLA-DR8 antigen