[Lipid peroxidation and the phospholipid composition of the liver plasma membranes in rabbits in traumatic shock and their pharmacological correction].
Changes in peroxidation of hepatic tissue lipids were studied in experiments on rabbits with Cannon's traumatic shock according to products reacting with thiobarbituric acid. The lipid composition of hepatocyte plasma membranes was studied by thin-layer chromatography. The levels of lipid peroxidation products and the ratio of phospholipid fractions changed depending on the stage of the process. Administration of superoxide dismutase in the initial periods of shock reduced the raised level of products reacting with thiobarbituric acid and maintained the ratio of phospholipid fractions in the hepatocyte plasma membrane at the initial level.
Kufterin
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Udovichenko
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D000818:Animals; D002855:Chromatography, Thin Layer / Q000379:methods; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008563:Membrane Lipids / Q000032:analysis / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D011817:Rabbits; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000627:therapeutic use; D013997:Time Factors
D008563:Membrane Lipids; D010743:Phospholipids; D013482:Superoxide Dismutase
Perekisnoe okislenie lipidov i fosfolipidnyĭ sostav plazmaticheskikh membran pecheni krolikov pri travmaticheskom shoke i ikh farmakologicheskaia korrektsiia.