[The clinical significance of anti-IgE antibodies in the treatment of allergic rhinopathy].
A simple assay, based on monoclonal antibodies, was used to measure "free" anti-IgE antibodies or anti-IgE antibodies in immune complexes of IgE and anti-IgE. No significant correlation was found between serum IgE levels and the concentration of anti-IgE antibodies. Furthermore, patients who were successfully treated by hyposensitization therapy showed only unmeasurable or extremely low anti-IgE antibody levels in their serum. However, patients who were unsuccessfully treated by hyposensitization had elevated anti-IgE serum titers. Thus, determination of anti-IgE antibodies might become a tool for predicting the success of hyposensitization therapy.
Loidolt
D
D
Universitäts-Hals-, Nasen- und Ohrenklinik, Universität Bern/Schweiz.
Vassella
C C
CC
de Weck
A L
AL
Stadler
B M
BM
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000627:therapeutic use*; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000628:therapy*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012882:Skin Tests
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E
Die klinische Bedeutung von Anti-IgE-Antikörpern für die Behandlung der allergischen Rhinopathie.