Angiotensin II inhibits acetylcholine release from human temporal cortex: implications for cognition.
Angiotensin II was shown to inhibit potassium-stimulated release of [3H]acetylcholine from slices of fresh human temporal cortex, obtained at surgery, and subsequently loaded with [3H]choline for the biochemical analyses. The inhibitory effect of angiotensin II was antagonised by the specific angiotensin II receptor antagonist [1-sarcosine, 8-threonine]-angiotensin II. High affinity binding sites were identified in the human temporal cortex using [125I]angiotensin II, and may provide the functional site of action of angiotensin II to modify [3H]acetylcholine release.
Barnes
J M
JM
Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, U.K.
Barnes
N M
NM
Costall
B
B
Horovitz
Z P
ZP
Ironside
J W
JW
Naylor
R J
RJ
Williams
T J
TJ
D000109:Acetylcholine / Q000493:pharmacokinetics* / Q000502:physiology; D000804:Angiotensin II / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D011945:Receptors, Angiotensin / Q000378:metabolism; D013702:Temporal Lobe / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D057911:Angiotensin Receptor Antagonists; D011945:Receptors, Angiotensin; D000804:Angiotensin II; C014805:angiotensin II, Sar(1)-Thr(8)-; D000109:Acetylcholine