[Analytical methods for stability testing of metronidazole infusion solutions].
UV-spectroscopy, thin layer- and high pressure liquid-chromatography as well as voltammetry (polarography) are suggested and compared as methods for use in stability testing of solutions of metronidazol. If some conditions are fulfilled UV-spectroscopy is the method of highest precision. TLC/HPTLC has advantages compared to HPLC, for more polar degradation products are visible at the starting point, whereas in HPLC these substances may be irreversibly adsorbed on the columne. Combination of HPLC and voltammetric (polarographic) techniques may lead to the optimal solution of this analytical problem with respect to best accuracy and precision (reproducibility) as compared in this paper.
Ebel
S
S
Institut für Pharmazie und Lebensmittelchemie, Bayerische Julius-Maximilians-Universität Würzburg.
Ledermann
M
M
Mümmler
B
B
D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007262:Infusions, Intravenous; D008795:Metronidazole / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D008795:Metronidazole
Analytische Methoden für die Stabilitätsprüfung von Metronidazol-Infusionslösungen.