The effects of Ro 15-4513 on ethanol-induced taste aversions.
Ro 15-4513 is an imidazobenzodiazepine that has been reported to block a range of behavioral effects of ethanol. In the present experiments, the effects of Ro 15-4513 were assessed on the acquisition of an ethanol-induced conditioned taste aversion. Specifically, rats were given a novel saccharin solution to drink followed by an injection of one of a range of doses of Ro 15-4513 (0.5 and 1.0 mg/kg, Experiment 1A, and 2.0 and 3.0 mg/kg, Experiment 1B) and an injection of ethanol (1.75 g/kg). Ro 15-4513 failed to block the acquisition of the ethanol-induced taste aversion. Possible reasons for this failure were discussed.
Jeffreys
R D
RD
Department of Psychology, American University, Washington, DC 20016.
Pournaghash
S
S
Glowa
J R
JR
Riley
A L
AL
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001386:Azides / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D051381:Rats; D012439:Saccharin; D013649:Taste
D001386:Azides; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513; D012439:Saccharin