Microbiological transformation of flavone and isoflavone.
1. Flavone and isoflavone were subjected to microbial transformation studies. Screening with 80 fungal species showed that flavone was transformed by a large number of microorganisms and in higher yields than isoflavone. 2. Large-scale fermentations of flavone followed by isolation and characterization of metabolites using spectroscopic analysis showed the formation of 4'-hydroxyflavone, 3',4'-dihydroxyflavone and two cleavage products identified as o-hydroxyphenyl-hydroxymethyl ketone and 1-(o-hydroxyphenyl)-1,2-ethanediol. However, fermentation of isoflavone gave only 4'-hydroxyisoflavone and 3',4'-dihydroxyisoflavone.
Ibrahim
A R
AR
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Abul-Hajj
Y J
YJ
D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D047309:Flavones; D005419:Flavonoids / Q000493:pharmacokinetics*; D005658:Fungi / Q000378:metabolism; D007529:Isoflavones / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D015262:Xenobiotics / Q000493:pharmacokinetics
D047309:Flavones; D005419:Flavonoids; D007529:Isoflavones; D015262:Xenobiotics; C043562:flavone