Cardiovascular effects of nicotine during physical activity and following meal consumption.
1. In two separate studies using healthy male smokers as subjects, the acute cardiovascular effects of a measured dose of nicotine (15 micrograms/kg) were examined in conjunction with light physical activity and following consumption of a meal, conditions typical of nicotine intake via smoking. 2. Increases in heart rate and systolic blood pressure attributable to nicotine were similar during rest, physical activity, and following eating, demonstrating additivity with the cardiovascular effects of activity and a caloric load. Diastolic blood pressure was less affected by nicotine. 3. These results indicate that cardiovascular activity is acutely increased following nicotine (smoking) regardless of other influences on the cardiovascular system. Such effects may help explain increased risks of acute cardiac abnormalities due to smoking.
Perkins
K A
KA
Western Psychiatric Institute & Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213.
Epstein
L H
LH
Stiller
R L
RL
Sexton
J E
JE
Marks
B L
BL
Jacob
R G
RG
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003971:Diastole / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005502:Food; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012907:Smoking / Q000378:metabolism; D013599:Systole / Q000187:drug effects; D014867:Water
D014867:Water; D009538:Nicotine