title: Topographical EEG differences between schizophrenic patients and controls during neuropsychological functional activation.
abstract: Ten DSM III schizophrenic patients belonging to an Active syndrome were compared with 10 age- and sex-matched normal controls on neuropsychological tests with concurrent monitoring of topographical EEG using a brain imager with a 28-electrode array. In line with predictions, abnormalities in patients were found in tests involving right hemispheric functions. Deficits were found in recognition memory for faces as distinct from a verbal recognition memory task. Right temporo-parietal involvement in the faces task was confirmed by an absence of beta II amplitude reduction in patients compared with controls in the right temporo-parietal region. A similar anomaly occurred in patients in a left- but not right-hand finger-thumb apposition test in left anterior and right posterior regions, and also in a passive visual fixation task where it was located bilaterally in the occipito-parietal region. Functional activation with neuropsychological tests holds promise as one approach to the validation of topographical mapping of brain electrical activity.
authors.affiliation: Department of Psychiatry, Charing Cross and Westminster Medical School, London, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Gruzelier
authors.forename: D
authors.initials: D
authors.lastname: Liddiard
authors.forename: L
authors.initials: L
authors.lastname: Davis
authors.forename: L
authors.initials: L
authors.lastname: Wilson
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012559:Schizophrenia / Q000503:physiopathology*