title: The incidence of seizures during tricyclic antidepressant drug treatment in a brain-injured population.
abstract: Tricyclic antidepressants (TCAs) have been associated with the occurrence of seizures both with overdoses and with therapeutic doses. Seizures with therapeutic doses of TCA have been reported in patients both with and without previous histories of seizures. The incidence of seizures possibly precipitated by TCAs was examined retrospectively in a population of 68 severely brain-injured patients, all of whom were at high risk for the development of seizures. Seizure histories, anticonvulsant use, comedication use, and other pertinent data were recorded before, during, and after TCA use. We conclude that 14 patients (19%) developed seizures largely caused by TCAs. Other possible contributing factors, clinical outcomes, and some recommendations are discussed.
authors.affiliation: Greenery Rehabilitation and Skill Nursing Center, Boston, Massachusetts.
authors.forename: B A
authors.initials: BA
authors.lastname: Wroblewski
authors.forename: K
authors.initials: K
authors.lastname: McColgan
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Whyte
authors.forename: W D
authors.initials: WD
authors.lastname: Singer
mesh_terms: D000293:Adolescent; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001930:Brain Injuries / Q000188:drug therapy*; D016009:Chi-Square Distribution; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000929:Antidepressive Agents, Tricyclic