[The correction of disorders in the microsomal oxidation system of the liver in experimental acute liver failure].
The effect of inductors and hepatic protectors on the detoxification function of the liver was studied in male rats with acute renal insufficiency (ARI). All the agents which were studied (phenobarbital, silibor, zixorin) caused an increase in the content of cytochromes P450 and b5 and in the activity of the main microsomal enzymes in the liver of rats with ARI. At the same time the survival of animals with ARI increased. The use of inductors and hepatic protectors as measures of pathogenetic therapy in disturbed detoxification function of the liver in ARI is promising.
Khakimov
Z Z
ZZ
Krakovskiĭ
M E
ME
D000208:Acute Disease; D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004790:Enzyme Induction / Q000187:drug effects; D005419:Flavonoids / Q000627:therapeutic use; D006591:Hexobarbital; D008107:Liver Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000401:mortality; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats
D001559:Benzhydryl Compounds; D005419:Flavonoids; C061938:silibor; D006591:Hexobarbital; C016914:flumecinol; D010634:Phenobarbital
Korrektsiia narusheniĭ mikrosomal'noĭ okislitel'noĭ sistemy pecheni pri éksperimental'noĭ ostroĭ pochechnoĭ nedostatochnosti.