[Uridine-induced ultrastructural changes in different formations of the brain].
In experiments on the rats there were identified two types of neurons, which age differentiated by their ability to form the coated vesicles in response to the administration of uridine. Presence or absence of the uridine receptors on the neuronal plasmalemmae causes different reaction of the neurons on the action of uridine. Coated vesicles transfer uridine to the lysosomes, where it degrades. Appearance of subsurface cisternae is a compensatory reaction on the deficit of neuronal plasmalemmae, which is necessary for the formation of coated vesicles. The satellite glia is the most resistant for the action of uridine.
Karkishchenko
N N
NN
Bardakhch'ian
E A
EA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D014529:Uridine / Q000378:metabolism / Q000494:pharmacology*
D014529:Uridine
Ul'trastrukturnye izmeneniia razlichnykh obrazovaniĭ golovnogo mozga, vyzvannye deĭstviem uridina.