title: Genetic drift of equine 2 influenza A virus (H3N8), 1963-1988: analysis by oligonucleotide mapping.
abstract: Comparative analysis by RNA oligonucleotide fingerprints of total genomic RNA as well as the individual RNA segments of equine 2 influenza A virus strains from 1963, 1968, 1979, 1984, 1987 and 1988 revealed genetic diversity. Strains from the epizootic outbreak during 1978-1979 showed minor differences among their genomes. The Swedish isolates from 1979 up to 1988 showed increasing genomic heterogeneity indicating genetic drift.
authors.affiliation: Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala.
authors.forename: M
authors.initials: M
authors.lastname: Berg
authors.forename: U
authors.initials: U
authors.lastname: Desselberger
authors.forename: I A
authors.initials: IA
authors.lastname: Abusugra
authors.forename: B
authors.initials: B
authors.lastname: Klingeborn
authors.forename: T
authors.initials: T
authors.lastname: Linné
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D003429:Cross Reactions; D005787:Gene Frequency; D006385:Hemagglutination Inhibition Tests; D053123:Influenza A Virus, H3N8 Subtype; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology; D009710:Nucleotide Mapping; D009841:Oligonucleotides / Q000032:analysis*; D012367:RNA, Viral / Q000032:analysis*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000914:Antibodies, Viral; D009841:Oligonucleotides; D012367:RNA, Viral