[A clinico-immunological assessment of the efficacy of combined methods of treating patients with different immunopathological forms of focal scleroderma].
To help the physicians choose a rational scheme of combined therapy of patients with various immunopathologic forms of focal scleroderma, the authors present a clinical and immunologic assessment of the efficacies of 2 combined therapeutic courses, enzyme immunotherapy and penicillin immunotherapy, as well as of the individual course of tactivin immunotherapy. Inclusion of tactivin in any complex therapeutic scheme appears to be necessary. In patients suffering from the condition for a long time, with multiple foci of involvement, tactivin should be combined with enzymic drugs, like hyaluronidase (lydase). Enzyme immunotherapy promoted a more active resolution of the skin process. Penicillin immunotherapy alone is disputable, and further studies of such treatment are necessary. Enzyme immunotherapy should be considered as the optimal scheme of rational combined treatment for focal scleroderma.
Suchkova
T N
TN
Sharova
N M
NM
Suchkov
S V
SV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D002908:Chronic Disease; D003131:Combined Modality Therapy / Q000379:methods; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000276:immunology / Q000628:therapy*; D013949:Thymus Extracts / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D010406:Penicillins; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; C001543:lidase; D006821:Hyaluronoglucosaminidase
Kliniko-immunologicheskaia otsenka éffektivnosti kompleksnykh metodov lecheniia bol'nykh s razlichnymi immunopatologicheskimi formami ochagovoĭ sklerodermii.