title: The chromosomal complements of cleaved human embryos resulting from in vitro fertilization.
abstract: Chromosome preparations were made from 25 cleaved abnormal human embryos at the two- to eight-cell stage after in vitro fertilization. Morphologically, these embryos showed either variable degrees of degeneration or an abnormal number of pronuclei before first cleavage. Among 14 successfully karyotyped embryos, only 3 had a normal chromosomal complement. Eleven showed chromosomal abnormalities, including triploidy, haploidy, and mosaicism. This finding documents a high incidence of chromosomal errors in morphologically abnormal early preimplantation embryos.
authors.affiliation: Department of Obstetrics and Gynaecology, Shaughnessy Hospital, Vancouver, British Columbia, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.forename: D K
authors.initials: DK
authors.lastname: Kalousek
authors.forename: C
authors.initials: C
authors.lastname: Zouves
authors.forename: B H
authors.initials: BH
authors.lastname: Yuen
authors.forename: V
authors.initials: V
authors.lastname: Gomel
authors.forename: Y S
authors.initials: YS
authors.lastname: Moon
mesh_terms: D002869:Chromosome Aberrations; D004622:Embryo, Mammalian; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy