title: Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats.
abstract: Endrin depletes glutathione levels and induces lipid peroxidation in various species of animals. We have, therefore, examined the effect of antioxidants on these parameters in endrin-treated rats. Butylated hydroxyanisole (BHA), vitamin E, vitamin C, and the glutathione precursor cysteine significantly inhibited hepatic glutathione depletion and lipid peroxidation induced by 4 mg endrin/kg body weight. Furthermore, these antioxidants provided partial protection against lethality produced by 8 mg endrin/kg body weight. These results suggest but do not prove that free radical-mediated lipid peroxidation and glutathione depletion may be involved in the toxic manifestations of endrin.
authors.affiliation: College of Pharmacy, University of Baghdad, Iraq.
authors.forename: I T
authors.initials: IT
authors.lastname: Numan
authors.forename: M Q
authors.initials: MQ
authors.lastname: Hassan
authors.forename: S J
authors.initials: SJ
authors.lastname: Stohs
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004732:Endrin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D005978:Glutathione / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000975:Antioxidants; D005978:Glutathione; D004732:Endrin