[Effects of dalargin on proliferative processes and vertical migration of cells of the corneal epithelium during stress].
We studied the effect of synthetic analogue of opioid peptides dalargin on kinetics of cell population of corneal epithelium during stress. It was found out that dalargin introduction before stress decreased the level of pathological mitoses induced by the acute stress action in white rats early in the morning. Dalargin prevented the activation of the proliferative process after the repeated stress activation, made stress milder. The stress induced vertical migration of the cells of the corneal epithelium normalized by dalargin. We believe these results show that dalargin has a good protective effect.
Timoshin
S S
SS
Berezhnova
N I
NI
Shvets
S I
SI
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D003315:Cornea / Q000166:cytology / Q000187:drug effects / Q000473:pathology*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000473:pathology* / Q000517:prevention & control; D013565:Sympatholytics / Q000494:pharmacology* / Q000627:therapeutic use
D013565:Sympatholytics; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na proliferativnye protsessy i vertikal'nuiu migratsiiu kletok épiteliia rogovitsy pri stresse.