Serial plasma fibrinogen changes accompanying sickle cell pain crisis.
Serial measurements of plasma fibrinogen concentrations have been made in nine homozygous sickle cell disease (SCD) patients during vaso-occlusive crisis. Fibrinogen was measured by the clot-weight technique. Changes in fibrinogen concentration showed a typical pattern, rising sharply and significantly to a maximum on approximately the second day of the onset of pain crisis and after treatment was instituted. Because of the well-defined and consistent response of this acute-phase reactant protein, this study suggests that serial measurements of fibrinogen could be used as a sensitive parameter to monitor the progression of sickle cell pain crisis.
Famodu
A A
AA
Department of Haematology, College of Medical Sciences, University of Benin, Nigeria.
Adedeji
M O
MO
Reid
H L
HL
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D010146:Pain / Q000097:blood
D005340:Fibrinogen