title: Redox properties of phenols, their relationships to singlet oxygen quenching and to their inhibitory effects on benzo(a)pyrene-induced neoplasia.
abstract: The inhibitory effects of synthetic phenolic compounds on benzo(a)pyrene-induced neoplasia of the mouse forestomach have been measured by Wattenberg et al. The efficiency of this inhibition has been estimated for each phenol, using R, the ratio of the number of tumors per mouse in the protected group over the number of tumours per mouse in the control group. We have observed a linear correlation between the chemoprotection efficiency R and the logarithm of the rate of quenching of singlet oxygen, k, by this family of phenols, log k being itself correlated with the one-electron oxidation potential of the phenols. These correlations suggest a charge transfer mechanism for the inhibition of neoplasia induced by benzo(a)pyrene. The correlations described provide a theoretical basis for scaling the inhibitors of mutagenicity induced by polycyclic aromatic compounds in terms of their oxidation potentials.
authors.affiliation: Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U 201, CNRS UA 481, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Scurlock
authors.forename: M
authors.initials: M
authors.lastname: Rougee
authors.forename: R V
authors.initials: RV
authors.lastname: Bensasson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants / Q000494:pharmacology; D001564:Benzo(a)pyrene; D002021:Buffers; D004563:Electrochemistry; D006415:Hematoporphyrins / Q000032:analysis; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000032:analysis; D010636:Phenols / Q000032:analysis* / Q000494:pharmacology; D011675:Pulse Radiolysis
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D002021:Buffers; D006415:Hematoporphyrins; D010636:Phenols; D001564:Benzo(a)pyrene; D010100:Oxygen