title: Histogenesis of corticotropin releasing factor-like immunoreactive amacrine cells in the rat retina.
abstract: The histogenesis of amacrine cells expressing corticotropin releasing factor-like immunoreactivity (CRF-LI) was examined in the rat retina by incorporating [3H]thymidine autoradiography and immunohistochemistry. Our results indicate that, during the period of amacrine cell generation, the population of CRF-LI amacrine cells are generated within a window of time from gestational days (ED)-16 to -20; the majority of them are produced by ED-18. No CRF-LI cells have been found to be 'born' postnatally. The histogenetic pattern of these cells follows a center-to-periphery gradient. Furthermore, CRF-LI cells in both the inner nuclear layer and the ganglion cell layer are generated in the same histogenetic wave and follow an identical temporo-spatial pattern. These results are consistent with and extend our previous findings of a differential change in CRF-LI cell density and total cell number during postnatal development.
authors.affiliation: Department of Neurobiology and Anatomy, University of Rochester Medical Center, NY 14642.
authors.forename: D R
authors.initials: DR
authors.lastname: Zhang
authors.forename: H H
authors.initials: HH
authors.lastname: Yeh
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D051381:Rats; D012160:Retina / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D013936:Thymidine
chemical_list: D003346:Corticotropin-Releasing Hormone; D013936:Thymidine