Effect of tumor-derived immunosuppressive factor(s) on interleukin 2 and on expression of interleukin 2 receptor.
In this paper, we have described the effects of tumor-derived immunosuppressive factor(s) (TDSF) on interleukin 2 (IL-2) production, on IL-2 responsiveness and on the expression of IL-2 receptors. The results showed that TDSF was able to markedly inhibit the production of IL-2 from PHA-stimulated lymphocytes and IL-2-dependent proliferation of activated lymphocytes, and to partially inhibit the expression of IL-2 receptor. These results suggest that inhibiting IL-2 production and responsiveness may be a major mechanism by which TDSF inhibit T lymphocyte proliferation and other immune responses. That TDSF exerted a very potent inhibiting action on IL-2 responsiveness is especially noticeable if we consider using IL-2 as an immunotherapeutic agent. This may be an important reason why treatment of tumor with IL-2 did not yield satisfactory results so far.
Wang
R D
RD
Department of Medical Molecular Biology, Tongji Medical University, Wuhan.
Luo
Y
Y
Feng
Z H
ZH
Chen
Z C
ZC
D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology*; D009363:Neoplasm Proteins / Q000494:pharmacology*; D015375:Receptors, Interleukin-2 / Q000187:drug effects*; D013601:T-Lymphocytes / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000378:metabolism
D006023:Glycoproteins; D007376:Interleukin-2; D009363:Neoplasm Proteins; D015375:Receptors, Interleukin-2; C038588:serum immunosuppressive factor, human