[Photodynamic effects of a concanavalin A-chlorin e6 conjugate on human fibroblasts].
To minimize the side effect of porphyrin photosensitizers and to reduce their active concentration, chlorine e6 was conjugated with concanavalin A. Photodynamic action of chlorine e6 and concanavalin A-chlorine e6 conjugate has been studied in human skin embryonic fibroblasts. The conjugate appeared to be 5 times more effective as compared to chlorine e6 due to concanavalin A-chlorine e6 endocytosis into intracellular compartments.
Akhlynina
T V
TV
Gulak
P V
PV
Serebriakova
N V
NV
Rozenkrants
A A
AA
Sobolev
A S
AS
D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D003470:Culture Media; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects
D003470:Culture Media; D011166:Porphyrins; D003208:Concanavalin A; C006969:chlorin
Fotodinamicheskoe deĭstvie kon"iugata konkanavalina A s khlorinom e6 na fibroblasty cheloveka.