A kinetic model for calcium distribution.
Models for the distribution of minerals in the body are of interest as they allow researchers to trace the effect of a dose on mineral levels in plasma, storage and other compartments. Limited models are available in the literature for tracing the distribution of a calcium dose through a short time period. We propose a more general kinetic model which includes both limited absorption through the gut and loss of calcium via excretion. This new method has the advantages of giving reasonable results over moderate time periods, and allowing the extrapolation of calcium levels in extracellular fluid and storage. We fit the model to published data in order to obtain typical parameter values. These values are then used to analyze the implications of the model regarding the effect of calcium dose on calcium levels in various compartments.
Sen
P
P
University of North Florida, Department of Mathematical Sciences, Jacksonville 32216.
Mohr
D
D
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors; D014018:Tissue Distribution / Q000502:physiology
D002118:Calcium