title: Altered pineal serotonin binding in some suicides.
abstract: Serotonergic abnormalities have been regularly reported in the brains of suicide victims. Because of evidence that pineal function is altered in depressed subjects and that serotonin-releasing axons may innervate the pineal, we assayed tritiated serotonin binding in a series of control and suicide pineals. High affinity binding was present, and there were apparent differences between some suicides and controls.
authors.affiliation: Department of Pathology, University of Kentucky Medical Center, Lexington.
authors.forename: D L
authors.initials: DL
authors.lastname: Sparks
authors.forename: K Y
authors.initials: KY
authors.lastname: Little
mesh_terms: D000328:Adult; D001667:Binding, Competitive / Q000502:physiology; D002423:Cause of Death; D002940:Circadian Rhythm / Q000502:physiology; D003645:Death, Sudden / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010870:Pineal Gland / Q000473:pathology*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013405:Suicide / Q000523:psychology*
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin