Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.
Mak
J W
JW
Institute for Medical Research, Kuala Lumpur, Malaysia.
Suresh
K
K
Lam
P L
PL
Choong
M F
MF
Striebel
H P
HP
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002009:Brugia / Q000187:drug effects; D002520:Cercopithecidae; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013844:Thiazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000871:Anthelmintics; D005369:Filaricides; D013844:Thiazoles; C051745:CGP 20376