title: Distant organ procurement in clinical lung- and heart-lung transplantation. Cooling by extracorporeal circulation or hypothermic flush.
abstract: The scarcity of suitable donors for single lung and heart-lung transplantation calls for methods of medium-term pulmonary preservation to allow for distant organ procurement. At our institution, the first five grafts (four heart-lung, one single lung) were cooled by means of a transportable extracorporeal circulation unit, while the last eight grafts (four heart-lung, four single lung) were flush-perfused with modified cold Euro-Collins solution. The technique of extracorporated circulation included aortic and right atrial cannulation and cooling to 12 degrees-14 degrees C (rectal temperature) using a bubble oxygenator. Bypass times ranged between 41 and 52 min. Following excision, the organs were transported in ice-cold donor blood for ischemic times from 171 to 310 min. For cold flush preservation, simultaneous coronary (cold St. Thomas's solution) and pulmonary artery perfusion (Euro-Collins solution, 50 ml/kg over 4 min) were initiated simultaneously. The organs were transported in cold Euro-Collins solution for ischemic times of 175 to 270 min. In heart-lung transplantations the first postoperative arterial PO2 upon arrival at the intensive care unit was 120 +/- 38 Torr in the extracorporeal circulation and 140 +/- 38 Torr in the Euro-Collins solution group. Six of eight patients were extubated within 48 h after cardiopulmonary grafting. We conclude that pulmonary function following heart-lung or single lung preservation with simple hypothermic flush is as good or better than that following extracorporeal circulation. Since distant organ retrieval is much more convenient without the latter, preservation using Euro-Collins solution is preferred.
authors.affiliation: Department of Surgery, Hannover-Medical School, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Haverich
authors.forename: T
authors.initials: T
authors.lastname: Wahlers
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfers
authors.forename: G
authors.initials: G
authors.lastname: Ziemer
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: H G
authors.initials: HG
authors.lastname: Fieguth
authors.forename: H G
authors.initials: HG
authors.lastname: Borst
mesh_terms: D000293:Adolescent; D000328:Adult; D002314:Cardioplegic Solutions / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003080:Cold Temperature; D005112:Extracorporeal Circulation; D005260:Female; D016041:Heart-Lung Transplantation; D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D014019:Tissue Donors; D009927:Tissue and Organ Procurement
chemical_list: D002314:Cardioplegic Solutions; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions