Cardiovascular correlates of predisposition to hypertension in pups of one kidney: one clip renal hypertensive dams.
We reported that the pups of one kidney:one-clip Goldblatt hypertensive (HT) rats have a predisposition to the induction of experimental hypertension. To investigate the nature of the predisposition, pups of HT dams were challenged with vasopressor agents at 28-days-of-age or treated with DOCA and 6.5% salt diet between 35 and 81 days-of-age. Pups of HT dams had a significantly greater blood pressure between 28 and 81 days-of-age and also showed a greater change in blood pressure when provided a 6.5% salt diet than did pups of normotensive dams. Pups of HT dams demonstrated a decreased bradycardic response after injection of angiotensin II (p less than .05) and a lesser change in mean arterial blood pressure after injection of angiotensin II or norepinephrine than did the pups from normotensive dams. These results suggest an effect of maternal hypertension on the development of cardiovascular control mechanisms in her offspring. The decreased pressor response suggests the predisposition is not due to an increased vascular sensitivity to vasopressors.
Jimenez
A E
AE
Department of Physiology and Biophysics School of Medicine, University of Louisville, KY 40292.
Passmore
J C
JC
D000375:Aging / Q000502:physiology; D000804:Angiotensin II; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D003900:Desoxycorticosterone; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine; D051381:Rats; D011919:Rats, Inbred Strains; D012982:Sodium, Dietary / Q000008:administration & dosage
D012982:Sodium, Dietary; D000804:Angiotensin II; D003900:Desoxycorticosterone; D009638:Norepinephrine