title: Intraventricular norepinephrine facilitates motor recovery following sensorimotor cortex injury.
abstract: Intraventricular norepinephrine, dopamine, or vehicle was administered to rats 24 hours after a unilateral sensorimotor cortex ablation to determine their potential roles in acceleration of motor recovery as measured by the beam-walking task. Norepinephrine was found to be the critical neurotransmitter in facilitating motor recovery. Blocking norepinephrine synthesis by dopamine-beta-hydroxylase inhibition coupled with dopamine administration failed to accelerate recovery, indicating a more important role for norepinephrine compared to its precursor dopamine in motor recovery after sensorimotor cortex injury.
authors.affiliation: Department of Rehabilitation Medicine, University of Wisconsin, Madison.
authors.forename: M G
authors.initials: MG
authors.lastname: Boyeson
authors.forename: D M
authors.initials: DM
authors.lastname: Feeney
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D009069:Movement Disorders / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001381:Azepines; D004791:Enzyme Inhibitors; C015590:4-methyl-1-homopiperazinedithiocarboxylic acid; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D009638:Norepinephrine