Cine-computed tomographic assessment of regional renal blood flow.
The new modality of cine-computed tomography was used to assess regional renal blood flow following hemorrhagic hypotension and administration of atrial natriuretic factor (ANF). As has also been established with other techniques, hypotension induced by hemorrhage caused cortical blood flow to fall from 5.3 (SD 0.8) to 2.1 (SD 1.1) ml.min-1g-1 (p less than 0.005; n = 7) proportionally more than inner medullary blood flow which fell from 0.45 (SD 0.24), to 0.26 (SD 0.08) ml.min-1g-1 (p less than 0.05) so that the ratio of the cortical to inner medullary blood flow decreased from 11.8 (SD 4.8) to 8.2 (SD 5.1) (p less than 0.01). In contrast, during natriuresis induced by ANF, cortical blood flow was unaltered (5.8, SD 1.1, vs 5.4, SD 0.9 ml.min-1g-1; NS; n = 5) while inner medullary blood flow declined from 0.66 (SD 0.13) to 0.51 (SD 0.11) (p less than 0.005) so the ratio of cortical to inner medullary blood flow increased from 8.8 (SD 1.3) to 10.9 (SD 1.7) (p less than 0.005). These results indicate that cine-CT appears to be an appropriate technique for demonstrating changes in distribution of intrarenal blood flow. Cine-CT may, therefore, be an attractive alternative for measuring regional renal blood flow.
Jaschke
W
W
Institut für Klinische Radiologie, Universität Heidelberg, West Germany.
Sievers
R S
RS
Lipton
M J
MJ
Cogan
M G
MG
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002933:Cineradiography; D004285:Dogs; D006470:Hemorrhage / Q000150:complications; D007022:Hypotension / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D007672:Kidney Cortex / Q000098:blood supply; D007679:Kidney Medulla / Q000098:blood supply; D012079:Renal Circulation; D014057:Tomography, X-Ray Computed