Associations of lecithin: cholesterol acyltransferase (LCAT) mass concentrations with exercise, weight loss, and plasma lipoprotein subfraction concentrations in men.
The relationships between plasma lecithin:cholesterol acyltransferase (LCAT) mass concentrations and lipids, apolipoprotein, and lipoprotein subfraction concentrations were studied in men assigned at random to a one-year exercise program (n = 48) and to a sedentary control condition (n = 31). Exercise training did not significantly affect mean concentrations of LCAT-mass. Moreover changes in LCAT within the exercise group were unrelated to distance run and weight loss. The baseline data and the one-year change data showed consistent positive correlations between LCAT concentrations and total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and apolipoprotein B concentrations, and consistently weak correlations between LCAT concentrations and high density lipoprotein (HDL)-cholesterol, HDL2, and apolipoprotein A-I concentrations. The strong correlation between LCAT and total cholesterol may account for LCAT's relationships with lipoprotein subfractions, apolipoprotein B and other lipoprotein cholesterol concentrations.
Williams
P T
PT
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, CA.
Albers
J J
JJ
Krauss
R M
RM
Wood
P D
PD
D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D015992:Body Mass Index; D015444:Exercise; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood*; D011897:Random Allocation; D012420:Running; D002785:Sterol O-Acyltransferase / Q000097:blood*; D015431:Weight Loss
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D002785:Sterol O-Acyltransferase