[The significance of immunity disorders in the development of tumorous effects during the long-term action of tritium in mice].
In experiments with CBA mice it was shown that the long-term influence of tritium oxide administered with drinking water daily during 180 days (370 kBq.g-1 of body mass, cumulative dose 8.7 Gy, dose rate 4.5 cGy.day-1) causes the development of immunity deficiency 90 days after the onset of the administration that persists for up to 270 days. There is a 34% decrease in the average life of irradiated animals and an increase in the number of malignant neoplasms (postmortem examination was performed after natural death or killing on days 250, 350 and 450). There is a direct relationship between the occurrence of malignant neoplasms and the immunity deficiency.
Kirillova
E N
EN
Nifatov
A P
AP
Revina
V S
VS
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology / Q000528:radiation effects; D001610:Beta Particles; D003602:Cytotoxicity, Immunologic / Q000276:immunology / Q000528:radiation effects; D005260:Female; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000209:etiology / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium / Q000633:toxicity*; D014867:Water; D014869:Water Intoxication
D014867:Water; D014316:Tritium; C033961:tritium oxide
Znachenie narusheniĭ immuniteta v razvitii opukholevykh éffektov pri dlitel'nom deĭstvii tritiia u mysheĭ.