Role of interleukin-2-receptor-positive cells and natural killer cells on rejected liver grafts of rats.
We explored the subpopulation and distribution of infiltrating leukocytes in rejected liver grafts using an orthotopic liver transplantation model of rats. We obtained the following results: (1) OX08- and recombinant-interleukin 2-receptor-positive cells were numerously increased in rejected grafts. (2) There was an abnormal distribution of R73-positive OX08-positive OX19-negative cells in the sinusoidal area of rejected grafts. These results suggest that R73-positive OX08-positive OX19-negative cells (natural killer cells or T cells?) have a role in the immunologic reaction in the sinusoidal area of rejected liver grafts of rats.
Hayashi
S
S
Department of Surgery II, University of Nagoya, School of Medicine, Japan.
Takagi
H
H
D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D015375:Receptors, Interleukin-2 / Q000502:physiology*
D007519:Isoantigens; D015375:Receptors, Interleukin-2