title: Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum.
abstract: Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.
authors.affiliation: Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.
authors.forename: W J
authors.initials: WJ
authors.lastname: Lederer
authors.forename: J R
authors.initials: JR
authors.lastname: Berlin
authors.forename: N M
authors.initials: NM
authors.lastname: Cohen
authors.forename: R W
authors.initials: RW
authors.lastname: Hadley
authors.forename: D M
authors.initials: DM
authors.lastname: Bers
authors.forename: M B
authors.initials: MB
authors.lastname: Cannell
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D008564:Membrane Potentials; D008856:Microscopy, Fluorescence; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D012964:Sodium / Q000378:metabolism*; D016276:Ventricular Function
chemical_list: D012964:Sodium; D002118:Calcium