title: Functional cerebral imaging by susceptibility-contrast NMR.
abstract: In vivo measurement of cerebral physiology by dynamic contrast-enhanced NMR is demonstrated. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility-induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston.
authors.forename: J W
authors.initials: JW
authors.lastname: Belliveau
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
authors.forename: H L
authors.initials: HL
authors.lastname: Kantor
authors.forename: R R
authors.initials: RR
authors.lastname: Rzedzian
authors.forename: D N
authors.initials: DN
authors.lastname: Kennedy
authors.forename: R C
authors.initials: RC
authors.lastname: McKinstry
authors.forename: J M
authors.initials: JM
authors.lastname: Vevea
authors.forename: M S
authors.initials: MS
authors.lastname: Cohen
authors.forename: I L
authors.initials: IL
authors.lastname: Pykett
authors.forename: T J
authors.initials: TJ
authors.lastname: Brady
mesh_terms: D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000378:metabolism; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D003287:Contrast Media