Penetration of enoxacin into middle ear effusion.
An oral dose of 400 mg enoxacin was given to each of 19 patients with long-standing secretory otitis media (SOM). A total of 27 samples of middle ear effusion (MEE) and blood were collected at different intervals during a 6-h period after administration of the drug. The concentration of enoxacin in MEE and serum was determined by a microbiological agar-well diffusion method. Enoxacin was found to penetrate rapidly into MEE but was eliminated slowly. The concentration in MEE was about the same at one hour as at 6 h (median value 0.6 mg/l) with a slight peak at 4 h (median value 0.9 mg/l). The peak in blood occurred after one hour (median value 1.8 mg/l), followed by a slow decrease in the concentration during the 6 h studied. The concentration of enoxacin in MEE exceeded the MICs of some (but not all) pathogens usually responsible for infections in chronic otitis media.
Sundberg
L
L
Department of Otorhinolaryngology, Central Hospital, Karlskrona, Sweden.
Edén
T
T
D000284:Administration, Oral; D001682:Biological Availability; D015365:Enoxacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D013997:Time Factors
D015365:Enoxacin