[1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms].
Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
Kuznetsov
I G
IG
Rasulov
M M
MM
Akabirov
A A
AA
Suslova
S K
SK
Voronkov
M G
MG
D000818:Animals; D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008930:Mitochondria, Liver / Q000378:metabolism; D017646:Organosilicon Compounds; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012825:Silicon / Q000494:pharmacology* / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism
D000897:Anti-Ulcer Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D017646:Organosilicon Compounds; C042292:1-ethoxysilatrane; D002784:Cholesterol; D012825:Silicon
1-Etoksisilatran: ul'tserostaticheskiĭ éffekt i ego vozmozhnye mekhanizmy.