Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum.
Experimental data do not support the idea that excitation-contraction coupling in heart muscle can be explained by a simple calcium-induced calcium release mechanism alone or a simple voltage-dependent calcium release mechanism alone. Our data on excitation-contraction coupling combined with the results of others suggest the need to either develop more complex and more sophisticated single-mechanism models, or to establish dual-control models.
Lederer
W J
WJ
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201.
Berlin
J R
JR
Cohen
N M
NM
Hadley
R W
RW
Bers
D M
DM
Cannell
M B
MB
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D008564:Membrane Potentials; D008856:Microscopy, Fluorescence; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D012964:Sodium / Q000378:metabolism*; D016276:Ventricular Function
D012964:Sodium; D002118:Calcium