Immunoreactive interleukin-1 beta localization in the rat forebrain.
To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.
Lechan
R M
RM
Department of Medicine, New England Medical Center, Boston, MA 02111.
Toni
R
R
Clark
B D
BD
Cannon
J G
JG
Shaw
A R
AR
Dinarello
C A
CA
Reichlin
S
S
D000818:Animals; D005625:Frontal Lobe / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000378:metabolism*; D011817:Rabbits
D007375:Interleukin-1