Aspirin at very ultra low dosage in healthy volunteers: effects on bleeding time, platelet aggregation and coagulation.
Aspirin at very ultra low dosage was tested in healthy volunteers (n = 20) in a randomized, double-blind and placebo-controlled trial. The results showed a bleeding time reduction (p less than 0.05) in volunteers having previously ingested aspirin. Platelet aggregation on platelet-rich plasma was not statistically modified after aspirin ingestion. Thrombin clotting time was always higher (p less than 0.05) in the treated group.
Doutremepuich
C
C
Laboratoire d'hématologie, CJF INSERM 88/13, Bordeaux, France.
de Sèze
O
O
Le Roy
D
D
Lalanne
M C
MC
Anne
M C
MC
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011897:Random Allocation
D000244:Adenosine Diphosphate; D003094:Collagen; D001241:Aspirin