title: Test of cure for genital Chlamydia trachomatis infection in women.
abstract: Convenient, reliable tests of cure for genital chlamydial infections have not been evaluated. Cervical appearance, endocervical Gram stain, enzyme immunoassay, and culture for Chlamydia trachomatis were evaluated during a pretreatment visit and at two subsequent randomized test-of-cure visits for 64 nongravid women with endocervical C trachomatis of 3544 patients screened. There were no useful correlations between C trachomatis resolution and cervical appearance. Endocervical Gram stain was determined to be unreliable for test-of-cure use. Both C trachomatis culture and enzyme-linked immunosorbent assay (ELISA) were shown to be effective for test-of-cure evaluation. The ELISA test became reliably negative 10 days after initiation of treatment and 1 to 5 days after the clearance of viable organisms detected by culture (P = .03). Convenience and cost considerations favor antigen detection methods. This study suggests that antigen detection methods can be used for situations in which test of cure is indicated, such as therapy noncompliance, circumstances supporting reinfection, pregnancy, complicated infections, requests for psychological reassurance, and evidence of persistent cervicitis.
authors.affiliation: Student Health Service, Medical College of Georgia, Augusta 30912.
authors.forename: D G
authors.initials: DG
authors.lastname: Ferris
authors.forename: F H
authors.initials: FH
authors.lastname: Lawler
authors.forename: R D
authors.initials: RD
authors.lastname: Horner
authors.forename: J C
authors.initials: JC
authors.lastname: Jernigan
authors.forename: F V
authors.initials: FV
authors.lastname: Crout
mesh_terms: D002690:Chlamydia Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D013752:Tetracycline / Q000627:therapeutic use; D002575:Uterine Cervicitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D013752:Tetracycline