Ethanol increases PGE and thromboxane production in mouse pregnant uterine tissue.
The teratogenic effect of ethanol in the C57BL/6J mouse can be attenuated by pretreatment with aspirin (ASA). One prominent effect of ASA is to inhibit prostaglandin (PGE) and thromboxane (TXB2) production. We examined the effect of in vivo ethanol exposure on PGE and TXB2 production in a uterine-embryo tissue sample of C57BL/6J mice either before or after in vivo ASA pretreatment on day 10 of gestation. Ethanol increased both PGE and TXB2 production by approximately 20%. ASA caused a marked reduction of PGE and TXB2 in both control and ethanol groups by approximately 80-90%. The mouse strain, gestation time, and study parameters used in this study were the same as in the previously reported ASA attenuation of the teratogenic effect of ethanol. Therefore, the present data add additional support to the hypothesis that prostaglandin and/or thromboxane production may be involved in at least some aspects of fetal alcohol syndrome.
Anton
R F
RF
Veterans Administration Medical Center, Charleston, South Carolina.
Becker
H C
HC
Randall
C L
CL
D000704:Analysis of Variance; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000096:biosynthesis*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011458:Prostaglandins E; D000431:Ethanol; D013929:Thromboxane B2; D001241:Aspirin