Improvement of neutrophil migration by systemic vitamin C in neonates.
The effect of oral vitamin C on chemotactic and random migration of neutrophils in 20 neonates (10 normal and 10 with suspected sepsis) was evaluated. Chemotaxis and random migration were studied between 24 and 48 hours of life, before and 24 hours after the administration of 400 mg (divided in four doses) of vitamin C. Chemotactic migration improved by 65% and random migration by 57% following vitamin C administration. The significant improvement in chemotaxis (P less than .01) and random migration may justify the inclusion of vitamin C as an adjunct to the therapy of neonatal sepsis.
Vohra
K
K
Department of Neonatology, Interfaith Medical Center, Brooklyn, New York.
Khan
A J
AJ
Telang
V
V
Rosenfeld
W
W
Evans
H E
HE
D001205:Ascorbic Acid / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003131:Combined Modality Therapy; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000188:drug therapy; D009504:Neutrophils / Q000187:drug effects
D001205:Ascorbic Acid