title: Mania after brain injury: neuroradiological and metabolic findings.
abstract: We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). While the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: S E
authors.initials: SE
authors.lastname: Starkstein
authors.forename: H S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: M L
authors.initials: ML
authors.lastname: Berthier
authors.forename: P
authors.initials: P
authors.lastname: Fedoroff
authors.forename: T R
authors.initials: TR
authors.lastname: Price
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: H N
authors.initials: HN
authors.lastname: Wagner
authors.forename: R
authors.initials: R
authors.lastname: Leiguarda
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging