title: Experimental tissue damage after subcutaneous injection of water soluble contrast media.
abstract: Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglumine salts rather than sodium salts caused more severe tissue damage; younger rats showed more severe tissue damage by WSCM of high osmolality.
authors.affiliation: Department of Radiology, Seoul National University, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: Y I
authors.initials: YI
authors.lastname: Kim
authors.forename: C W
authors.initials: CW
authors.lastname: Kim
authors.forename: M C
authors.initials: MC
authors.lastname: Han
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D007279:Injections, Subcutaneous; D007472:Iohexol / Q000633:toxicity / Q000031:analogs & derivatives; D007479:Iopamidol / Q000633:toxicity; D007483:Iothalamic Acid / Q000633:toxicity / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000473:pathology*
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D007472:Iohexol; C038192:iopromide; C002587:ioxitalamic acid; D007479:Iopamidol; D007485:Ioxaglic Acid