The effects of perinatal hypoxia on pentylenetetrazol-induced seizures in developing rats.
The effects of perinatal hypoxia on susceptibility to seizures due to a single dose (55 mg/kg, i.p.) of pentylenetetrazol (PTZ) were examined, in 15-, 20-, 30-, 60- and 90 to 120-day-old rats. The rats exposed to hypoxia at 10 days of age and the unexposed controls showed similar developmental changes in the types of seizures, ictal electro-encephalograms and severity scores, the last being lowest at 30 days of age. However, the susceptibility to seizures induced by PTZ, which was measured by the mean number of generalized convulsions (GCs) as well as a mean duration of the 1st GC and severity score, was more enhanced in the rats exposed to perinatal hypoxia than in the control group at every age. The present study suggests that hypoxia in rats results in greater seizure susceptibility throughout the developmental period.
Matsumoto
M
M
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D000860:Hypoxia / Q000150:complications*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology*
D010433:Pentylenetetrazole