[Fixation of fluorescent estrone derivative on human breast cancer cells. Correlation with age, menopause status and histopathology].
Values were determined by means of a ligand binding assay using 17-FE (17-fluoresceinated estrone) in 53 breast cancer patients. 49.1% of the tumors were positive and 50.9 negative. There was no correlation between the positivity and tumor size and localisation. The proportion of positivity increased with advancing age. In the group of postmenopausal women, the incidence of positivity was higher than in the premenopausal group, although the difference was not statistically significant. Histopathologically, tumors with high and intermediate grades of differentiation were often more significatively positive when compared to poorly differentiated tumors.
Baltali
E
E
Université d'Hacettepe, Faculté de médecine, département d'oncologie, Ankara, Turquie.
Souadka
A
A
el Hafed
A
A
Wydadi
M
M
Kettani
F
F
Alamy
H
H
el Gueddari
B
B
Morchid
M
M
Bouih
A
A
Souadka
F
F
D000328:Adult; D000367:Age Factors; D000368:Aged; D001665:Binding Sites; D001943:Breast Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D004970:Estrone / Q000031:analogs & derivatives / Q000378:metabolism*; D005260:Female; D005453:Fluorescence; D006801:Humans; D008024:Ligands; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged
D008024:Ligands; D004970:Estrone
Fixation d'un dérivé fluorescent de l'oestrone sur les cellules de cancers mammaires humains. Corrélation avec l'âge, le statut ménopausique et l'histopathologie.