Brain membrane fluidity and lipid peroxidation in Alzheimer's disease.
Membrane fluidity and lipid peroxidation in 4 brain areas from patients with Alzheimer's disease (AD) and matched controls were determined by measuring fluorescence anisotropy of the lipophilic probe 1,6-diphenyl-1,3,5-hexatriene (DPH) and by the thiobarbituric acid test respectively. Fluorescence anisotropy of DPH was not changed in any of the 4 areas in AD compared to controls. Basal levels of malondialdehyde (MDA; an intermediate in the lipid peroxidation process) were also not changed in different brain regions of AD and controls. However, stimulated MDA production determined by incubating tissue with FeSO4 plus H2O2 produced significantly higher MDA levels in AD brain than in controls.
Hajimohammadreza
I
I
Department of Neuroscience, Institute of Psychiatry, London, U.K.
Brammer
M
M
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D008560:Membrane Fluidity
D008314:Malonates; D008315:Malondialdehyde