6-Methylangelicins: new monofunctional photochemotherapeutic agents for psoriasis.
The monofunctional furocoumarins, the 6-methylangelicins, were tested for their antiproliferative activity with various animal models and for genotoxicity in micro-organisms and in mammalian cells. The most active compound was 6,4,4'-trimethylangelicin, which showed a high antiproliferative effect and reduced genotoxicity in comparison with 8-methoxypsoralen (8-MOP). Some of these compounds were also tested clinically by topical application on 17 patients with psoriasis. They appeared to be more active than 8-MOP in clearing psoriasis without inducing skin phototoxicity. The methylangelicins also caused skin pigmentation.
Cristofolini
M
M
Division of Dermatology, Hospital of Santa Chiara, Trento, Italy.
Recchia
G
G
Boi
S
S
Piscioli
F
F
Bordin
F
F
Baccichetti
F
F
Carlassare
F
F
Tamaro
M
M
Pani
B
B
Baburdi
N
N
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D011564:Furocoumarins / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D011564:Furocoumarins; D004247:DNA; C041621:4,4',6-trimethylangelicin; D008730:Methoxsalen