Antibodies to interleukin 2 in sera of autoimmune-prone mice.
Autoimmune-prone mice spontaneously develop the disease characterized by autoantibodies to a wide variety of antigens. In the present study, we have demonstrated that IgG antibodies to interleukin 2 (IL-2) are to be found in serum of autoimmune mice in association with ageing. These antibodies can neutralize the biological activity of IL-2 and thus play an important role in the etiopathogenesis of autoimmune disease.
Tabata
M
M
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Kobayashi
K
K
Kaga
S
S
Hashimoto
M
M
Kasama
T
T
Fukushima
T
T
Yoshida
K
K
Yamagata
N
N
Sekine
F
F
Ohno
I
I
D000375:Aging / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology*; D004198:Disease Susceptibility; D005260:Female; D006824:Hybridization, Genetic; D007074:Immunoglobulin G / Q000032:analysis; D007376:Interleukin-2 / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood / Q000502:physiology*; D012217:Rheumatoid Factor / Q000032:analysis
D000906:Antibodies; D007074:Immunoglobulin G; D007376:Interleukin-2; D012217:Rheumatoid Factor