title: [Juvenile granulosa cell tumor].
abstract: Granulosa cell juvenile tumours, defined in 1976 by Scully as a separate unit are found mostly in girls during the first two decades of life. On inspection under an optic microscope they are characterized by the presence of non-differentiated "blastemoid" structures and the formation of solid follicular formations and cysts. In our first case we observed a bilateral juvenile tumour made up of granulosa cells in a 8-month-old girl where the tumour produced symptoms of pseudopubertas praecox isosexualis. In the second case in a 9-month-old girl also with symptoms of pseudopubertas praecox isosexualis the authors detected in the left ovary a tumour which probably is a less differentiated variety of the juvenile granulosa cell tumour. These tumours belong into the group of little differentiated gonadal-stromal tumours with ICD-O code M-8590/1.
authors.affiliation: Patologicko-anatomický ústav fakulty dĕtského lékarství Univerzity Karlovy, Praha.
authors.forename: A
authors.initials: A
authors.lastname: Zuntová
authors.forename: K
authors.initials: K
authors.lastname: Motlík
authors.forename: V
authors.initials: V
authors.lastname: Smelhaus
authors.forename: J
authors.initials: J
authors.lastname: Horejsí
mesh_terms: D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000473:pathology; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology
vernacular_title: Juvenilní nádor z bunĕk granulózy.