title: Opossum (Didelphis virginiana) "little" and "big" gastrins.
abstract: 1. "Little" gastrins from most mammalian species are 17 amino acid peptides and the precursor "big" gastrins are 34 amino acid peptides. 2. "Little" gastrins of the New World hystricomorphs, guinea-pig and chinchilla, are 16 amino acid peptides due to deletion of a glutamic acid in the region 6-9 from their NH2-terminus and the corresponding "big" gastrins are 33 amino acid peptides. 3. Antral gastrins from the opossum, a New World marsupial, have a glutamic acid deletion in the same region as the hystricomorph gastrins. 4. Opossum "big" gastrin is a 33 amino acid peptide with the following sequence: less than ELGPQDLPYLTADLSKKQGPWLEEEEAYGWMDF#.
authors.affiliation: Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, NY 10468.
authors.forename: Y
authors.initials: Y
authors.lastname: Shinomura
authors.forename: J
authors.initials: J
authors.lastname: Eng
authors.forename: S C
authors.initials: SC
authors.lastname: Rattan
authors.forename: R S
authors.initials: RS
authors.lastname: Yalow
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005755:Gastrins / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D009893:Opossums / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics / Q000302:isolation & purification*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D005755:Gastrins; D011498:Protein Precursors; C013706:big gastrin