title: Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. II. Micronucleus test in bone marrow and hepatocytes.
abstract: The antileprosy drug, clofazimine, was tested for its possible genotoxicity using micronucleus (MN) tests in mice. A significantly higher incidence of MN in bone marrow erythrocytes, particularly in polychromatic erythrocytes, as well as in regenerated hepatocytes revealed a positive clastogenic effect of the drug. The drug also had a marked antimitotic effect as indicated by a negative correlation with the dose.
authors.affiliation: Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.
authors.forename: B
authors.initials: B
authors.lastname: Roy
authors.forename: R K
authors.initials: RK
authors.lastname: Das
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002991:Clofazimine / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests
chemical_list: D000927:Anticonvulsants; D002991:Clofazimine