[Agonist-induced platelet adhesion: use of the method in patients with myocardial infarction].
A new method of agonist-induced platelet adhesion has been developed for the evaluation of platelet activity. Platelet adhesion to plastic was stimulated by low doses of ADP, epinephrine and stable thromboxane analogue U46619. These inducers cause more than 3-fold increase of platelet adhesion in concentrations by 5-10 times lower than those necessary for stimulation of platelet aggregation in Born aggregometer. The method was applied for evaluation of platelet adhesive activity in patients with myocardial infarction. A dramatic increase of agonists-induced platelet adhesion was registered in patients with acute infarction, most significantly expressed when epinephrine was used as platelet agonist.
Atakha ova
L E
LE
Mazurov
A V
AV
Katsenovich
E R
ER
Repin
V S
VS
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*
D011450:Prostaglandin Endoperoxides, Synthetic; D000244:Adenosine Diphosphate; D004837:Epinephrine
Agonistindutsirovannaia adgeziia trombotsitov, primenenie metoda u bol'nykh s infarktom miokarda.