[Substantiation of hygienic standard of lincomycin in the air of the work area].
The main parameters of lincomycin toxicometry were studied in animals. It was shown that the compound was low toxic after its oral or intraperitoneal administration in single doses, had no local irritant and skin resorptive effects and did not accumulate. The allergenic properties were slightly pronounced. The intoxication picture after a single inhalation was characterized by renal dysfunction, erythropenia, neutrophilia, lymphopenia and impairment of the normal intestinal microflora. The zone of the specific antimicrobial effect was equal to 8. On chronic inhalation, the signs of the specific antimicrobial effect were of the paramount importance: Limch am was equal to 4.7 mg/m3 and Limch exceeded 18.3 mg/m3. In the concentrations used, the substance had no embryotoxic and gonadotropic effects. The level of 0.5 mg/m3 (for Hazard Class 2) was recommended and approved as the maximum allowable concentration.
Anufrieva
R K
RK
Baru
R V
RV
Vasilenko
O S
OS
Zel'tser
I Z
IZ
Lapchinskaia
A V
AV
Churagulova
N K
NK
Shtegel'man
L A
LA
D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004345:Drug Industry / Q000592:standards*; D005260:Female; D006168:Guinea Pigs; D008034:Lincomycin / Q000008:administration & dosage / Q000592:standards / Q000633:toxicity*; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D009787:Occupational Medicine / Q000592:standards*; D051381:Rats; D014586:USSR
D000395:Air Pollutants, Occupational; D008034:Lincomycin
Obosnovanie gigienicheskogo standarta linkomitsina v vozdukhe rabocheĭ zony.