Behavioral reactivity following 5-MeODMT administration in 5,7-DHT-pretreated killer rats.
Grouped, nonkiller and killer animals were centrally injected either with vehicle or with 5,7-dihydroxytryptamine. After a period of 7-10 days, forepaw treading and hindlimb abduction were induced by 5-MeODMT administration in all sham and lesioned rats. As expected, behavioral supersensitivity was observed in grouped and nonkiller lesioned rats. A reduced increase in 5-MeODMT-induced behaviors was obtained in killer lesioned animals. 5-HT uptake studies showed a comparable reduction of 5-HT uptake within all the lesioned rats. This evidence suggests an altered capacity to promote adaptive changes on 5-HT sites in killer rats following the destruction of central serotonergic fibers.
Cuadra
G R
GR
Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Argentina.
Molina
V A
VA
D015116:5,7-Dihydroxytryptamine / Q000633:toxicity; D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002552:Cerebral Ventricles / Q000187:drug effects; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000494:pharmacology*
D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D014363:Tryptamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin