title: [A toxicological hygiene study of a dye made from abattoir blood for sausage products].
abstract: Toxicologic and hygienic study of a pigment from abattoir blood--carboxyn (based on carboxyhemoglobin) was conducted on noninbred white rats in subacute (3 months) and chronic (12 months) experiments. The condition of the animals, their bw growth, blood morphology, erythrocyte sedimentation rate, the content of hemoglobin, protein and iron in the blood serum were evaluated. Activity of the following enzymes was studied: catalase and sorbitol dehydrogenase--in the blood serum; glucose 6-phosphate dehydrogenase, lactate dehydrogenase and cytochrome P-450 content--in the liver. Internal organs of the rats were subjected to histological investigation. The data obtained have evidenced the absence of some signs of biotransformation of the red complex of carboxyhemoglobin, or its toxic effect on the experimental animals. It has been concluded that carboxyn can be used as a coloring component in the production of sausage (in the amount of up to 2% of the sausage meat mass).
authors.forename: I V
authors.initials: IV
authors.lastname: Lerina
authors.forename: A M
authors.initials: AM
authors.lastname: Belous
authors.forename: T L
authors.initials: TL
authors.lastname: Kolesnik
authors.forename: G N
authors.initials: GN
authors.lastname: Shatrov
authors.forename: V F
authors.initials: VF
authors.lastname: Kozlova
authors.forename: A N
authors.initials: AN
authors.lastname: Zaĭtsev
mesh_terms: D000003:Abattoirs; D000818:Animals; D001769:Blood / Q000187:drug effects; D002263:Carboxyhemoglobin / Q000032:analysis / Q000187:drug effects; D004396:Coloring Agents / Q000633:toxicity*; D005503:Food Additives / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008460:Meat; D008461:Meat Products; D051381:Rats; D013997:Time Factors; D014886:Weaning
chemical_list: D004396:Coloring Agents; D005503:Food Additives; D002263:Carboxyhemoglobin
vernacular_title: Toksikologo-gigienicheskoe izuchenie krasitelia iz boenskoĭ krovi dlia kolbasnykh izdeliĭ.