title: [Effect of modifiers of natural biological response on the functional activity of macrophages (oncological aspect)].
abstract: Induction of cytotoxicity by biological response modifiers (BRMs) is only one aspect of macrophage activation. After the use of BRMs there were other changes in the functional activity of cells and in particular their increased production or secretion of a number of growth factors. Thus, activation of macrophage antitumor activity induced by BCG vaccine was transitory while activation of growth factor production was more stable in time which finally led to increased proliferation of tumor cells. Combined use of cyclophosphamide and BCG vaccine significantly increased not only the toxicity induced by BCG vaccine but also their liberation of the growth factors. Such macrophages lost their ability to control the growth of a small number of the tumor cells cultivated in their presence. Development of ways for directed activation of macrophages aimed at elimination of the tumor cells which survived the chemotherapy should include evaluation of the combined effect of various BRMs and chemotherapeutics on both antitumor and protumor activity i. e. ability to produce the factors stimulating the tumor growth.
authors.forename: S A
authors.initials: SA
authors.lastname: Gromov
authors.forename: B O
authors.initials: BO
authors.lastname: Voĭtenkov
authors.forename: V B
authors.initials: VB
authors.lastname: Okulov
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D006131:Growth Inhibitors; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D010529:Peritoneal Cavity / Q000166:cytology
chemical_list: D001500:BCG Vaccine; D006131:Growth Inhibitors; D003520:Cyclophosphamide
vernacular_title: Vliianie modifikatorov biologicheskogo otveta prirodnogo proiskhozhdeniia na funktsional'nuiu aktivnost' makrofagov (onkologicheskiĭ aspekt).