title: Perinatal exposure to a high NaCl diet increases the NaCl intake of adult rats.
abstract: To determine the effect of differences in perinatal NaCl exposure on NaCl intake, adult Sprague-Dawley female rats were maintained on diets containing either 0.12, 1.0, or 3% NaCl throughout pregnancy and lactation. The offspring were continued on the these same diets to 30 days postpartum. Thereafter, all offspring were fed the same basal diet containing 1% NaCl. At 90 days of age, the adult offspring were placed in metabolism cages for 7 days and fed 1% NaCl chow for days 1-2, and 0% NaCl chow for days 3-7. On days 6-7, the animals were free to consume both water and 0.3 M NaCl. When dietary NaCl was available, adult rats exposed perinatally to the high NaCl diet excreted significantly more sodium on days 1-2 and 6-7 than did the rats exposed to either the mid or low NaCl diets. There were no differences in sodium excretion during sodium deprivation on days 3-5. The 0.3 M NaCl intake of the high NaCl-exposed rats was also significantly greater than the intake of the mid and low NaCl-exposed rats. In another group of adult rats, exposed perinatally to either a low or high NaCl diet, the spontaneous 24-hr intake of water and 0.3 M NaCl was measured after repeated episodes of acute sodium depletion. Sodium depletion was induced by 48 hr of dietary sodium deprivation combined with a single subcutaneous injection of 5 mg furosemide. Acute sodium depletion was found to augment existing differences in NaCl intake between low and high NaCl-exposed rats.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: University of Alabama, Department of Psychology, Birmingham, AL 35294.
authors.forename: R J
authors.initials: RJ
authors.lastname: Contreras
authors.forename: K W
authors.initials: KW
authors.lastname: Ryan
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D005260:Female; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000652:urine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000172:deficiency; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D012982:Sodium, Dietary; D012964:Sodium; D011188:Potassium