title: [Evaluation of the inflammatory process in hepatic disorders: immunochemistry of C alpha-reactive protein and of alpha 1-acid glycoprotein].
abstract: C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1-GPA) two acute phase reactants, have both been monitored in patients suffering from hepatocellular diseases, compared with healthy subjects. Immunochemical findings, in hepatic amebiasis, revealed a higher incidence of increased alpha 1-GPA levels (86% of patients, as compared to 46% for CRP), whereas during liver primitive cancer and cirrhosis inverse pattern occurs. In viral chronic hepatitis, lesser perturbations were observed. In contrast, a simultaneous increase of both proteins is strong supporting evidence for the severity of disease with an unfavourable prognostic.
authors.affiliation: Faculté de Pharmacie, Laboratoire de Biochemie, Abidjan, Còte-d'Ivoire.
authors.forename: D
authors.initials: D
authors.lastname: Monnet
authors.forename: G
authors.initials: G
authors.lastname: Kokora
authors.forename: M
authors.initials: M
authors.lastname: Cisse
authors.forename: M
authors.initials: M
authors.lastname: Ferly-Therizol
authors.forename: J
authors.initials: J
authors.lastname: Moreau
authors.forename: G
authors.initials: G
authors.lastname: Durand
authors.forename: A
authors.initials: A
authors.lastname: Lonsdorfer
authors.forename: A E
authors.initials: AE
authors.lastname: Yapo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006505:Hepatitis / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism; D006801:Humans; D008101:Liver Abscess, Amebic / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis*
chemical_list: D009961:Orosomucoid; D002097:C-Reactive Protein
vernacular_title: Evaluation du processus inflammatoire dans les atteintes hépatiques: dosage immunochimique de la protéine C alpha-réactive et de l'alpha 1-glycoprotéine acide.