title: Excretion of iodine-123-hippuran, technetium-99m-red blood cells, and technetium-99m-macroaggregated albumin into breast milk.
abstract: The amount of radioactivity excreted in breast milk following three different nuclear medicine procedures on twelve nursing mothers has been measured. Some of this information has already been incorporated into the latest guidelines on suspension of feeding after maternal radiopharmaceutical administration. The overall radiation dose that the patients' babies would have sustained had breast feeding not been interrupted has been estimated as an effective dose equivalent. A model has been developed to describe the relationship between clearance of activity from the milk, time between expressions, and the fraction of milk expressed. Some simple guidance is given on calculation of suitable interruption times for any individual mother from counts on her milk samples.
authors.affiliation: Department of Nuclear Medicine, Manchester Royal Infirmary, United Kingdom.
authors.forename: M R
authors.initials: MR
authors.lastname: Rose
authors.forename: M C
authors.initials: MC
authors.lastname: Prescott
authors.forename: K J
authors.initials: KJ
authors.lastname: Herman
mesh_terms: D004912:Erythrocytes; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000032:analysis*; D007465:Iodohippuric Acid / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism*; D008895:Milk, Human / Q000032:analysis*; D013667:Technetium / Q000032:analysis*; D013668:Technetium Tc 99m Aggregated Albumin / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D007465:Iodohippuric Acid; D013667:Technetium