[Estradiol binding and lipid metabolism in the plasma membrane of myometrial cells during tumor growth].
The study was concerned with evaluation of the parameters of specific binding of 17-beta-estradiol to myometrial plasma membrane in tumor growth versus lipid profile of the membrane and A2 and C phospholipase activity. Tumor growth was shown to involve an increase in the association constant of plasma membrane, changes in the lipid profile and activity of the enzymes. The role of these factors in myometrial carcinogenesis is discussed.
Sergeev
P V
PV
Mineeva
E N
EN
Ukhina
T V
TV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002462:Cell Membrane / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D008875:Middle Aged; D009215:Myometrium / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D010741:Phospholipases A / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011959:Receptors, Estradiol / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism; D014594:Uterine Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D008563:Membrane Lipids; D010743:Phospholipids; D011959:Receptors, Estradiol; D004958:Estradiol; D010741:Phospholipases A; D010738:Type C Phospholipases
Sviazyvanie éstradiola i metabolizm lipidov v plazmaticheskikh membranakh kletok miometriia pri opukholevom roste.