Interleukin 2 (IL 2) inhibitor in rheumatoid synovial fluid: correlation with prognosis and soluble IL 2 receptor levels.
A soluble activity inhibiting over 50% of the CTLL-2 cell line response to recombinant human interleukin 2 (IL 2) was found in 17 of 29 (59%) rheumatoid synovial fluids. To study the prognosis value of this activity, 16 rheumatoid synovial fluids were collected before a radiation synovectomy of the knee with 7 mCi of 90Yt. Patients with a good clinical result after the synovectomy had a lower IL 2 inhibitory activity than those with a bad or incomplete result (P less than 0.01). Levels of inhibitory activity and of soluble IL 2 receptors were correlated with each other and with the response of the synovitis to the radiation synovectomy. These results extend the clinical usefulness of soluble IL 2 receptor measurements and indicate a correlation between the immune activation of the rheumatoid synovitis and its clinical activity.
Miossec
P
P
INSERM Unit 291, Montpellier, France.
Elhamiani
M
M
Chichehian
B
B
D'Angeac
A D
AD
Sany
J
J
Hirn
M
M
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000532:radiotherapy; D001681:Biological Assay; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007719:Knee Joint / Q000528:radiation effects; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013582:Synovial Fluid / Q000276:immunology* / Q000528:radiation effects
D007376:Interleukin-2; D008222:Lymphokines; D015375:Receptors, Interleukin-2; C046147:interleukin 2 inhibitor