title: Intussusception in the Syrian golden hamster.
abstract: Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production. Plasma levels of gastric inhibitory polypeptide (GIP) were reduced 80% (P less than 0.01) but peptide tyrosine/tyrosine and enteroglucagon in plasma were increased 290 and 526% respectively in hamsters with intussusception. Variations in dietary fatty acid composition had no effect but intussusception was not observed after changing the dietary carbohydrate from sucrose to starch.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Cunnane
authors.forename: S R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D000818:Animals; D003106:Colon / Q000473:pathology; D006224:Cricetinae; D004032:Diet / Q000009:adverse effects*; D005243:Feces / Q000032:analysis; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D007443:Intussusception / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008055:Lipids / Q000032:analysis; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D012376:Rodent Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D013395:Sucrose / Q000009:adverse effects
chemical_list: D008055:Lipids; D013395:Sucrose; D005749:Gastric Inhibitory Polypeptide