title: [Intubation in otorhinolaryngologic surgery: propofol versus propofol-suxamethonium].
abstract: This study was carried out to assess the conditions of intubation in head and neck surgery when using propofol alone or associated with suxamethonium. Sixty patients were randomly allocated in two groups of 30. Group I was given 3 mg.kg-1 propofol and Group II 3 mg.kg-1 propofol immediately followed by 1.5 mg.kg-1 suxamethonium. All patients were premedicated orally with midazolam 0.1 mg.kg-1, 0.5 to 1 mg atropine and 7 to 10 micrograms.kg-1 alfentanil, while a colloidal solute (Plasmion) up to 250-500 ml was infused. One minute after injection of propofol, lidocaine 5% was pulverized on the glottis and intubation performed. The mean time required for intubation was similar in both groups: 128 +/- 10 sec in group I vs 132 +/- 9.7 sec in group II. Thirty-five % of patients had to be considered as difficult to intube but the mean times in these cases were not statistically different: 169 +/- 14 sec in group I vs 175 +/- 13 sec in group II. Opening of the glottis was found to be better in group II than in group I (p less than 0.01) and bucking was more frequent in group I (p less than 0.01). Successful intubation was obtained after one attempt at a similar rate in the two groups. The haemodynamic variations consisted in a significant decrease of systolic blood pressure compared to the initial value but these variations were similar in the two groups at each time (2.3 and 5 min) from induction.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Département d'Anesthésie et de Réanimation Chirurgicale, Hôpital Tenon, Paris.
authors.forename: L
authors.initials: L
authors.lastname: Dominici
authors.forename: R
authors.initials: R
authors.lastname: Gondret
authors.forename: S
authors.initials: S
authors.lastname: Dubos
authors.forename: O
authors.initials: O
authors.lastname: Crevot
authors.forename: P
authors.initials: P
authors.lastname: Deligné
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000601:surgery; D015742:Propofol; D011897:Random Allocation; D013390:Succinylcholine
chemical_list: D013390:Succinylcholine; D015742:Propofol
vernacular_title: Intubation en chirurgie ORL: propofol vs propofol-suxaméthonium.