Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?
Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
Bruguerolle
B
B
Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Marseille, France.
Giaufre
E
E
Morisson-Lacombe
G
G
Rousset-Rouviere
B
B
Arnaud
C
C
D000763:Anesthesia, Caudal; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000097:blood* / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D011229:Preanesthetic Medication; D011485:Protein Binding / Q000187:drug effects
D003975:Diazepam; D002045:Bupivacaine