title: High predictivity of galactosyl-hydroxylysine in urine as an indicator of bone metastases from breast cancer.
abstract: We measured the urinary excretion of galactosyl-hydroxylysine (GH) and hydroxyproline in two groups of women with breast cancer, with (M+, n = 24) and without (Mo, n = 30) clinical, scintigraphic, or radiological evidence of bone metastases. Both these compounds are excreted in larger amounts in the M+ group than in the Mo patients. However, GH, which is a specific marker for bone collagen, provides better predictivity for bone metastases than does hydroxyproline: 92% sensitivity and 90% specificity vs 74% and 79%, respectively, for hydroxyproline.
authors.affiliation: Dipartimento di Biochimica, Università degli Studi de Trieste, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Moro
authors.forename: C
authors.initials: C
authors.lastname: Gazzarrini
authors.forename: C
authors.initials: C
authors.lastname: Modricky
authors.forename: L
authors.initials: L
authors.lastname: Rovis
authors.forename: B
authors.initials: B
authors.lastname: de Bernard
authors.forename: E
authors.initials: E
authors.lastname: Galligioni
authors.forename: D
authors.initials: D
authors.lastname: Crivellari
authors.forename: S
authors.initials: S
authors.lastname: Morassut
authors.forename: S
authors.initials: S
authors.lastname: Monfardini
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology / Q000652:urine*; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000652:urine; D008991:Monitoring, Physiologic; D009362:Neoplasm Metastasis; D012306:Risk
chemical_list: D006901:Hydroxylysine; C007817:galactosylhydroxylysine