Toxicity of vidarabine on hemopoietic progenitor cells in mice.
9 beta-D-Arabinofuranosyladenine (adenine arabinoside, vidarabine, ara-A), is employed as an antiviral compound mainly against herpes virus infections. Toxicity of ara-A is of concern in clinical applications. This work reports quantitative changes of bone marrow hemopoietic progenitors in mice treated with ara-A. The experimental model is based on time survival curves following repeated intraperitoneal injections (200, 400 or 800 mg/kg twice a day for 4 days) of different doses of the drug. Our results show that ara-A causes damage to the hemopoietic progenitors. The induced damage is roughly proportional to the injected amount of the drug. Following termination of ara-A administration all tested populations rapidly recovered.
Mencoboni
M
M
Istituto Scientifico di Medicina Interna, Università di Genova, Italia.
Lerza
R
R
Bogliolo
G
G
Flego
G
G
Pannacciulli
I
I
D000818:Animals; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013997:Time Factors; D014740:Vidarabine / Q000008:administration & dosage / Q000633:toxicity*
D014740:Vidarabine