The long-term effects of diazepam and pentylenetetrazol on the potentiated startle response.
Stress desensitization is observed as a decrease in the disruptive effects of a stressor on behavior when the organism is repeatedly exposed to the stressor. For instrumental behavior, stress desensitization was also reported for rats preexposed to anxiogenic drugs; stress sensitization was reported for rats preexposed to an anxiolytic compound. The present study investigated whether similar effects are found in a noninstrumental task situation. First, rats received 12 daily injections of pentylenetetrazol (PTZ, 20 mg/kg, IP), diazepam (DZP, 5 mg/kg, IP) or saline. After each injection the effect of the drugs on the acoustic startle reflex was measured. No drugs were given during the remainder of the experiment. Eight days later rats were given 5 days of Pavlovian fear conditioning to establish a light as a shock signal. During the next 3 days, potentiation of the startle response by the light was measured. None of the drug treatments had an effect on startle potentiation, indicating that stress sensitivity is not affected by previous administration of PTZ and DZP in a noninstrumental task. An explanation for the different effects found for instrumental and noninstrumental tasks is suggested.
Hijzen
T H
TH
Netherlands Institute for Drugs and Doping Research, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Woudenberg
F
F
Slangen
J L
JL
D000161:Acoustic Stimulation; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D003214:Conditioning, Classical; D003975:Diazepam / Q000494:pharmacology*; D004597:Electroshock; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*; D013315:Stress, Psychological / Q000523:psychology; D013997:Time Factors
D003975:Diazepam; D010433:Pentylenetetrazole