title: Penetration of ciprofloxacin into human pleural fluid.
abstract: The concentrations of ciprofloxacin (1.5 mg/kg of body weight) in serum and in uninfected pleural exudates were studied after one and three intravenous injections had been given at 8-h intervals. The drug was assayed in serum and in pleural fluid by high-performance liquid chromatography. The peak concentrations in pleural fluid 1.5 h after one and three injections were (mean +/- standard error of the mean) 0.52 +/- 0.09 and 0.77 +/- 0.15 mg/liter, respectively; the corresponding 8-h concentrations were 0.19 +/- 0.05 and 0.39 +/- 0.10 mg/liter. At 1 and 8 h, the ratios of mean concentrations in pleural fluid to mean concentrations in serum were 112 and 158%, respectively, after one injection and 77 and 122% after three injections. This study suggested that there is a satisfactory pleural penetration of ciprofloxacin after intravenous injection.
authors.affiliation: Infectious Disease Clinic, Erasmus University Hospital, Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Jacobs
authors.forename: M
authors.initials: M
authors.lastname: Marchal
authors.forename: P
authors.initials: P
authors.lastname: de Francquen
authors.forename: J P
authors.initials: JP
authors.lastname: Kains
authors.forename: D
authors.initials: D
authors.lastname: Gangji
authors.forename: J P
authors.initials: JP
authors.lastname: Thys
mesh_terms: D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005122:Exudates and Transudates / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010994:Pleura / Q000378:metabolism*
chemical_list: D002939:Ciprofloxacin