Alternative fitness models with the same allele frequency dynamics.
For any set of one- or two-locus genotypic fitnesses there are alternative sets, usually frequency-dependent and often with quite different biological meanings, that give rise to the same equations for change of allele or haplotype frequencies. Therefore, it is not possible to distinguish among alternative fitness models from allele or haplotype frequency trajectories or equilibrium distributions. For a single locus and for two loci when linkage equilibrium can be assumed, a simple procedure generates some of the alternative fitness sets.
Denniston
C
C
Laboratory of Genetics, University of Wisconsin, Madison 53706.
Crow
J F
JF
D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D008957:Models, Genetic