Autosomal dominant cramping disease.
A family was studied in which four generations (16 of 41 members) suffered from painful recurrent muscle cramping. A clear pattern of autosomal dominant inheritance was noted. The cramping first developed during adolescence or early adulthood. Electromyographic analysis indicated a neurogenic origin. The cramps seemed to be due to dysfunction of the motor neurons. The mechanisms underlying this alteration are unclear and require further investigation.
Ricker
K
K
Department of Neurology, University of Würzburg, West Germany.
Moxley
R T
RT
D000293:Adolescent; D000328:Adult; D000368:Aged; D004576:Electromyography; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000235:genetics*; D010375:Pedigree