[Appearance of parkinsonian syndrome after administration of delta sleep-inducing peptide into the rat substantia nigra].
Bilateral microinjection of delta-sleep-inducing peptide (DSIP) (10.0 nmol) into the substantia nigra provoked hypokinesia and rigidity in rats observed during 4.0 hours. Injection of DSIP in dose of 5.0 nmol into the substantia nigra or into the nuclei caudati in dose of 10.0 nmol did not induce such symptoms. The enhanced slow-wave activity was recorded in caudate nuclei during hypokinesia and rigidity which demonstrated the formation of the generator of pathologically enhanced excitation (GPEE). The systemically cyclodol administration resulted in abolishment of rigidity and increase in locomotor activity. The conclusion is that bilateral intranigral DSIP injection caused acute parkinson syndrome in rats due to the formation of cholinergic GPEE in caudate nuclei. The hyperactive caudate nuclei act as the pathologic determinant which induces the parkinson syndrome.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mikhaleva
I I
II
D000208:Acute Disease; D000818:Animals; D002421:Caudate Nucleus / Q000503:physiopathology; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage*; D007267:Injections; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra; D014282:Trihexyphenidyl / Q000494:pharmacology
D003701:Delta Sleep-Inducing Peptide; D014282:Trihexyphenidyl
Iavleniia parkinsonicheskogo sindroma pri vvedenii del'ta-son-indutsiruiushchego peptida v chernuiu subtantsiiu krys.