title: [Diltiazem and modulation of platelet aggregation].
abstract: The calcium antagonists including Diltiazem have been proved to inhibit platelet aggregation caused by ADP. In order to demonstrate the anti-aggregant properties of Diltiazem, a study was conducted on the aggregation curves in blood samples from 20 healthy subjects before and after a week's treatment with 240 mg oral Diltiazem per diem. The experiment confirmed the anti-aggregant properties of Diltiazem which is therefore useful in the treatment of cardiovascular disease given its capacity to dilate the coronary arteries and inhibit platelet aggregation.
authors.affiliation: Divisione di Medicina, Ospedale E. Morelli, Reggio Calabria.
authors.forename: G
authors.initials: G
authors.lastname: Colica
authors.forename: D
authors.initials: D
authors.lastname: Salnitro
authors.forename: F
authors.initials: F
authors.lastname: Scopelliti
authors.forename: D
authors.initials: D
authors.lastname: Sergi
authors.forename: R
authors.initials: R
authors.lastname: Pellegrino
authors.forename: A
authors.initials: A
authors.lastname: Zoccali
authors.forename: P
authors.initials: P
authors.lastname: Lanucara
mesh_terms: D000244:Adenosine Diphosphate / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D000328:Adult; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D004110:Diltiazem
vernacular_title: Diltiazem e modulazione dell'aggregazione piastrinica.