High-molecular-weight alkaline phosphatase and alkaline phosphatase lipoprotein X complex in cholestasis and hepatic malignancy.
Alkaline phosphatase (ALP) fast liver isoenzyme is now known as high-molecular-weight ALP. This ALP isoenzyme represents fragments of hepatic cell plasma membranes with various membrane-bound enzymes localized on the surface. High-molecular-weight ALP isoenzyme is present in patients' serum samples in conditions associated with intrahepatic and extrahepatic cholestasis and primary or metastatic hepatic malignancy. High-molecular-weight ALP isoenzyme may coexist with ALP of the normal liver and with ALP lipoprotein X. Alkaline phosphatase ultrafast liver isoenzyme is now known as ALP lipoprotein X complex.
Wolf
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Department of Pathology, University of California Medical Center, San Diego.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D002779:Cholestasis / Q000201:enzymology*; D004587:Electrophoresis, Agar Gel; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008073:Lipoprotein-X / Q000097:blood*; D008113:Liver Neoplasms / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D007527:Isoenzymes; D008073:Lipoprotein-X; D000469:Alkaline Phosphatase