Influence of dietary minerals on apolipoprotein B metabolism in rabbits fed semipurified diets containing casein.
Rabbits were fed semipurified casein diets containing either 4% or 2.5% mineral mix for 8 weeks. Both groups maintained weight throughout the experimental period. The plasma total cholesterol concentration was significantly higher after 4 weeks on diet and slightly higher after 8 weeks in animals fed the lower level of minerals. Plasma IDL- and LDL-cholesterol concentrations after 4 weeks and HDL-cholesterol concentrations after 8 weeks were significantly higher in animals fed the 2.5% compared to those fed the 4% mineral mix. Kinetic experiments showed that in rabbits fed the lower level, the fractional catabolic and production rates of VLDL-apo B were lower and a greater proportion of IDL-apo B was derived from sources other than VLDL compared to the animals fed the higher level. LDL-apo B kinetics were not significantly different between the 2 groups. These data suggest that a reduction in dietary minerals enhances casein-induced hypercholesterolemia.
Samman
S
S
Department of Biochemistry, University of Western Ontario, London, Canada.
Khosla
P
P
Carroll
K K
KK
D000818:Animals; D001055:Apolipoproteins B / Q000097:blood*; D002364:Caseins / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005526:Food, Formulated; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced; D008074:Lipoproteins / Q000493:pharmacokinetics; D008297:Male; D008903:Minerals / Q000494:pharmacology*; D011817:Rabbits
D001055:Apolipoproteins B; D002364:Caseins; D008078:Cholesterol, LDL; D008074:Lipoproteins; D008903:Minerals; D002784:Cholesterol