[Clonogenic hemopoietic cells (CFU-S) in mouse pre- and postnatal ontogeny].
Content of three classes of clonogenic haemopoietic cells (CFU-S-7, CFU-S-11 and CFU-S-ep) was determined in haemopoietic organs of mouse during embryogenesis (10, 14 and 18 day) and postnatal ontogenesis (2, 3 and 7 day, 1, 2, 3 and 18 month). CFU-S-7 and CFU-S-11 that from big splenic colonies on 7th and 11th days of transplantation are present in liver, spleen and bone marrow at all developmental stages. However their concentration and CFU-S-7 CFU-S-11 ratio change in haemopoietic organs. CFU-S-ep that form small colonies on 11th day are observed before birth in liver and spleen and 1 week after birth there and also in bone marrow but are practically absent from haemopoietic organs of older animals. Thus, CFU-S compartment structure is characterized by definite ratio of its subpopulations. It seems to reflect functional state of haemopoietic system during development.
Domaratskaia
E I
EI
Prianishnikova
O D
OD
Khrushchov
N G
NG
D000375:Aging; D000818:Animals; D001854:Bone Marrow Cells; D002999:Clone Cells / Q000166:cytology; D003114:Colony-Forming Units Assay; D005865:Gestational Age; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008099:Liver / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D015017:Yolk Sac / Q000166:cytology / Q000196:embryology / Q000254:growth & development
Klonogennye krovetvornye kletki (KOE-S) v pre- i postnatal'nom ontogeneze myshi.