title: An analysis of pollutant gas transport and absorption in pulmonary airways.
abstract: A mathematical model of ozone absorption, or for any soluble gas that has similar transport properties, is developed for a branching network of liquid-lined cylinders. In particular, we investigate specific flow regimes for finite length tubes where boundary layer phenomena and entrance effects exist in high Reynolds and Peclet (Pe) number airways. The smaller airways which have lower Reynolds and Peclet number flows are modelled by incorporating the detailed analysis found in [10] and modifying it for airways which have alveolated surfaces. We also consider a reacting gas and treat specific regimes where the reaction front is located at the air-liquid interface, within the liquid or at the liquid-tissue interface. Asymptotic methods are used in regions of the tracheobronchial tree where Pe much less than 1 and Pe much greater than 1. In addition, the fact that the radial transport parameter gamma much less than 1 for this toxin, and others such as nitrous oxides, is employed to simplify the analysis. The ozone concentrations, airway absorption and tissue dose are examined as a function of airway generation for several values of the governing parameters. The general result is a maximal dosing in airway generations 17 to 18 that is much larger (up to an order of magnitude) than the predictions of previous theories.
authors.affiliation: Biomedical Engineering Department, Northwestern University, Evanston, Ill 60208.
authors.forename: J B
authors.initials: JB
authors.lastname: Grotberg
authors.forename: B V
authors.initials: BV
authors.lastname: Sheth
authors.forename: L F
authors.initials: LF
authors.lastname: Mockros
mesh_terms: D000042:Absorption; D000393:Air Pollutants; D000818:Animals; D001692:Biological Transport; D005740:Gases / Q000493:pharmacokinetics*; D006801:Humans; D008954:Models, Biological; D010126:Ozone / Q000493:pharmacokinetics*; D011650:Pulmonary Alveoli / Q000378:metabolism; D012137:Respiratory System / Q000378:metabolism*
chemical_list: D000393:Air Pollutants; D005740:Gases; D010126:Ozone