Bilirubin and bile acids removal by haemoperfusion through synthetic resin "Persorb".
A new type of styrene-divinylbenzene copolymer coated with polyhema was tested for biocompatibility and ability to remove bile acid, bilirubin, phenols and cholesterol in dogs with surgically induced biliary obstruction. After 4-hr hemoperfusion through a polypropylene column containing 325 g of resin, performed 7-10 days after the ligature of the cystic and common bile duct, the serum levels of bile acids, bilirubin, phenols and cholesterol decreased by 60.9 +/- 30.3% (p less than 0.001), 34.8 +/- 12.2% (p less than 0.001), 19.4 +/- 15.6% (p less than 0.001) and 15.3 +/- 4.2% (p less than 0.05), respectively. The procedure was well tolerated, no bleeding or other adverse reactions occurred. The average platelet count decreased by 19.4 +/- 15.6% (p less than 0.05). Hemoperfusion through the Czechoslovak resin coated with polyhema is safe and efficient for removal of bile acids and other protein-bound and lipid-soluble substances which accumulate in cholestatic syndromes and hepatic failure. Thus, it may play an important role in the treatment of such events as a method of artificial liver support.
Filip
K
K
Institute for Clinical and Experimental Medicine, Prague.
Malý
J
J
Horký
J
J
Tlustáková
M
M
Kálal
J
J
Vrána
M
M
D000818:Animals; D001647:Bile Acids and Salts; D001663:Bilirubin; D001651:Cholestasis, Extrahepatic / Q000628:therapy; D004285:Dogs; D006464:Hemoperfusion; D008297:Male; D011137:Polystyrenes
D001647:Bile Acids and Salts; D011137:Polystyrenes; C003771:Amberlite XAD-2 resin; D001663:Bilirubin