Pharmacological activities of Grewia bicolor roots.
Intraperitoneal administration of the ethanol extract of Grewia bicolor root (300 mg/kg) to rats in early pregnancy (+1-4 days) did not affect the number of conception sites, but significantly increased resorption. In late pregnancy (+19-20 days), the extract (300 mg/kg) did not affect duration of the gestation period; however, 400 mg/kg was lethal to all mother rats. The active compound, apparently a peptide, exerted a serotonin-like effect on rat uterus, rat fundus and rabbit jejunum. All these effects were abolished by methysergide. A transient serotonin-like rise in cat blood pressure was produced by the active fraction and this effect was also blocked by cyproheptadine.
Mohamed
A E
AE
Medicinal and Aromatic Herb Research Institute, National Council for Research, Khartoum, Sudan.
Karrar
M A
MA
Salih
A E
AE
Bashir
A K
AK
Ali
M B
MB
Khalid
S A
SA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010936:Plant Extracts / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects
D010936:Plant Extracts