Direct visualization of death of neurones projecting to specific targets in the developing rat brain.
The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neurones which project axons to specific and identified target regions within the nervous system.
Harvey
A R
AR
Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth.
Robertson
D
D
Cole
K S
KS
D000578:Amidines; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D003051:Cochlea / Q000254:growth & development* / Q000502:physiology; D005456:Fluorescent Dyes; D009410:Nerve Degeneration; D009847:Olivary Nucleus / Q000254:growth & development* / Q000502:physiology; D051381:Rats; D012160:Retina / Q000254:growth & development* / Q000502:physiology; D013477:Superior Colliculi / Q000254:growth & development* / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology
D000578:Amidines; D005456:Fluorescent Dyes; C037945:diamidino yellow