title: Study of mature cells in human myeloid malignancies by premature chromosome condensation.
abstract: The premature chromosome condensation technique allows cytogenetic studies (chromosomes scoring or karyotyping after banding) of mature non cycling cells. In conjunction with cell fractionation, it appears a powerful tool to study spontaneous or therapy-induced maturation of cells of acute myelogenous leukemia or myelodysplastic syndrome patients. It is useful for determining the involvement of multiple lineages in hematopoietic diseases.
authors.affiliation: Service d'Hématologie Clinique, Pavillon Marcel-Bérard 1F, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
authors.forename: J D
authors.initials: JD
authors.lastname: Tigaud
mesh_terms: D002875:Chromosomes; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000235:genetics*