title: Biodistribution of a novel antiestrogen (Analog II) in the mouse and rat.
abstract: The biodistribution of a novel antiestrogen Analog II was determined in the mouse and rat. The tritiated product, [3H]-Analog II was prepared by New England Nuclear and was purified by preparative chromatography using silica gel and petroleum ether/methylene chloride (80:20). The fat tissue had the highest uptake due to the hydrophobic nature of Analog II. The second highest uptake was in the mouse uterine tissue which was greater than that observed in the rat. The differences in biodistribution between the mouse and rat may partially explain the differences in biological activity of Analog II previously observed in these two animal species.
authors.affiliation: Division of Medicinal Chemistry and Pharmacodynamics, College of Pharmacy, University of Oklahoma, Oklahoma City 73190.
authors.forename: M T
authors.initials: MT
authors.lastname: Griffin
authors.forename: J T
authors.initials: JT
authors.lastname: Pento
authors.forename: R A
authors.initials: RA
authors.lastname: Magarian
authors.forename: G K
authors.initials: GK
authors.lastname: Mousissian
authors.forename: G P
authors.initials: GP
authors.lastname: Basmadjian
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D014018:Tissue Distribution; D014599:Uterus / Q000378:metabolism
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen; C035174:tamoxifen analog II