Spontaneous lesions in beagle dogs used in toxicity studies.
Spontaneous histopathologic lesions were examined in 276 young beagle dogs (8 to 15 months old) used in toxicity studies. Mononuclear cell infiltration in the liver was observed with the highest incidence (more than 95%). Calcium deposition in the kidney, mononuclear cell infiltration in the salivary glands, pigmentation in the spleen, and cortical atrophy in the thymus were seen with relatively high incidences (more than 30%). The incidence of mononuclear cell infiltration in the gallbladder, vacuolization of the tubular epithelium in the kidney, and vacuolization of the zona glomerulosa cell in the adrenal gland showed differences between the sexes. No abnormalities were seen in the spinal cord, sternum, and femur. Although most lesions observed are considered to be age-related, several were considered to be due to congenital anomalies observed in some organs.
Morishima
H
H
Drug Safety Research Laboratories, Takeda Chemical Industries, Co., Ltd., Osaka, Japan.
Nonoyama
T
T
Sasaki
S
S
Miyajima
H
H
D000818:Animals; D001284:Atrophy; D002114:Calcinosis / Q000473:pathology; D004285:Dogs; D005260:Female; D007674:Kidney Diseases / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D010859:Pigmentation Disorders / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology; D012737:Sex Factors; D013158:Splenic Diseases / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014116:Toxicology