title: Involvement of phytochelatins in NiCl2-triggered protection against induction of chromatid aberrations by TEM and MH in Vicia faba root tip meristems?
abstract: Conditioning treatment of Vicia faba root tip meristem cells with NiCl2 prior to challenge treatment with triethylenemelamine (TEM) or maleic hydrazide (MH) triggered protective functions against both these clastogens, i.e., resulted in a significantly reduced yield of metaphases with chromatid aberrations. Protection was prevented by pretreatment with buthionine sulfoximine (BSI), an inhibitor of the synthesis of plant phytochelatins (PCs), indicating that the NiCl2-triggered PC synthesis may be involved in the protective functions induced by NiCl2 conditioning treatment. BSI (instead of NiCl2) conditioning treatment triggered protection against MH but not against TEM.
authors.affiliation: Zentralinstitut für Genetik und Kulturpflanzenforschung Gatersleben, Akademie der Wissenschaften der DDR.
authors.forename: R
authors.initials: R
authors.lastname: Rieger
authors.forename: A
authors.initials: A
authors.lastname: Michaelis
authors.forename: S
authors.initials: S
authors.lastname: Takehisa
mesh_terms: D019328:Buthionine Sulfoximine; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations; D004347:Drug Interactions; D007887:Fabaceae; D008300:Maleic Hydrazide / Q000633:toxicity*; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D009532:Nickel / Q000494:pharmacology*; D010940:Plant Proteins / Q000494:pharmacology*; D010946:Plants, Medicinal; D011724:Pyridazines / Q000633:toxicity*; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D014265:Triethylenemelamine / Q000633:toxicity*
chemical_list: D010940:Plant Proteins; D011724:Pyridazines; D013438:Sulfhydryl Compounds; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D009532:Nickel; D014265:Triethylenemelamine; D008300:Maleic Hydrazide