[A comparative study between Gd-BOPTA, a biliary excretion contrast medium, and Gd-DTPA in the magnetic resonance imaging of the rat liver].
A new lipophilic compound, Gd-BOPTA, presenting a high rate (38.6%) of biliary excretion was tested as an hepato-specific MR contrast agent. Its adequacy was compared to that of Gd-DTPA in laboratory animals. T1-weighted spin-echo sequences (TR 220 ms, TE 20 ms) both before and after the administration of the 2 contrast agents (doses: 0.25, 0.5, and 1.0 mmol/kg) showed better liver enhancement with Gd-BOPTA than with Gd-DTPA. Gd-BOPTA superiority was more evident at lower doses, while at 1.0 mmol/kg a comparable enhancement was achieved. Inversion recovery sequence at the T-null of liver parenchyma before contrast (TR 800 ms, TE 30 ms, TI 100 ms) was performed after the injection of 0.1 and 0.5 mmol/kg of Gd-DTPA and Gd-BOPTA. This sequence allowed the good and long-lasting liver enhancement achieved with Gd-BOPTA to be even better demonstrated, while Gd-DTPA provided only a slight and early enhancement with 0.1 mmol/kg and returned to baseline values 60' after the injection of the highest dose (0.5 mmol/kg). Gd-BOPTA proved to be a good contrast agent to obtain prolonged liver enhancement, thus providing the radiologist with the long time needed to acquire conventional T1-weighted pulse sequences.
Patrizio
G
G
Cattedra di Radiologia, Università, L'Aquila.
Pavone
P
P
Cardone
G
G
Pietroletti
R
R
Passariello
R
R
Tettamanti
E
E
Musu
C
C
Felder
E
E
D000085:Acetates / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005682:Gadolinium / Q000493:pharmacokinetics / Q000633:toxicity; D019786:Gadolinium DTPA; D007928:Lethal Dose 50; D008099:Liver / Q000032:analysis / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D004369:Pentetic Acid / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats
D000085:Acetates; D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
Studio comparativo tra Gd-BOPTA, mezzo di contrasto ad escrezione biliare, e Gd-DTPA nell'imaging a Risonanza Magnetica del fegato di ratto.