Studies on the prevention of 5-fluorouracil-induced oral mucositis.
Oral mucositis is a major toxic effect related to 5-fluorouracil (5-FU) therapy. Clinical studies have attempted to identify an effective antidote for this untoward side effect. Early pilot studies suggested that an allopurinol mouthwash could lessen 5-FU-induced mucositis. However, a randomized, double-blinded, placebo-controlled crossover study did not suggest that an allopurinol mouthwash had any prophylactic value in this clinical situation. An ongoing, randomized clinical protocol is testing cryotherapy as a method of inhibiting 5-FU-induced stomatitis. No clinically appropriate prophylactic measure for preventing 5-FU-induced mucositis has been found to date.
Loprinzi
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CL
Mayo Clinic, Rochester, MN 55905.
Dose
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AM
D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use; D003452:Cryosurgery; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes; D013280:Stomatitis / Q000139:chemically induced / Q000517:prevention & control*
D009067:Mouthwashes; D000493:Allopurinol; D005472:Fluorouracil