Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure.
Information is presented for the serum concentrations during haemodialysis of primidone, phenobarbitone, and phenylethylmalonamide (PEMA) in a patient with renal failure receiving chronic primidone therapy. The concentrations of drug and metabolites fell during haemodialysis, but PEMA concentrations were above normal at all times. The average renal clearance of PEMA during 6 h of dialysis was found to be 84.7 +/- 4.6 ml min-1.
Streete
J M
JM
Poisons Unit, Guys Hospital, London, England.
Berry
D J
DJ
Jones
J A
JA
Groggin
M J
MJ
D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008314:Malonates / Q000493:pharmacokinetics*; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood / Q000493:pharmacokinetics; D010657:Phenylethylmalonamide / Q000097:blood / Q000493:pharmacokinetics*; D011324:Primidone / Q000097:blood / Q000493:pharmacokinetics; D006435:Renal Dialysis; D013997:Time Factors
D008314:Malonates; D011324:Primidone; D010657:Phenylethylmalonamide; D010634:Phenobarbital