Analgesic activity of Cassia alata leaf extract and kaempferol 3-o-sophoroside.
The analgesic activity of an extract of the leaves of Cassia alata and kaempferol 3-O-sophoroside were studied after intraperitoneal injection in mice and rats using the tail clip, tail flick, tail immersion and acetic acid-induced writhing methods and the results compared with morphine. Maximum analgesic activity of the extract was apparent 120 min after injection. Fifty milligrams of kaempferol 3-O-sophoroside appeared equivalent to 100 mg of the extract.
Palanichamy
S
S
Department of Pharmacology, Thanjavur Medical College, India.
Nagarajan
S
S
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002366:Cassia / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D044949:Kaempferols; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D005419:Flavonoids; D044949:Kaempferols; D010936:Plant Extracts; C064309:kaempferol 3-O-sophoroside; C006552:kaempferol; D011794:Quercetin