Studies on the release of drugs from O/W emulsion ointments using mathematical interpretations. Part 4: Kinetic analysis of drug release from thick layers.
A kinetic two-compartment model has been used in order to described drug release from thick layers of O/W emulsion ointments containing amphoteric surfactants as emulsifiers. It has been shown that the rate of release can be evaluated by the distribution coefficient of the drug between the compartments as accurately as by the use of effective diffusion coefficients.
Bialik
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Department of Applied Pharmacy and Drug Technology, Faculty of Pharmacy, Medical University School of Silesia, Sosnowiec, Poland.
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004655:Emulsions; D005079:Excipients; D008954:Models, Biological; D009824:Ointments; D010599:Pharmacokinetics; D013501:Surface-Active Agents
D004655:Emulsions; D005079:Excipients; D009824:Ointments; D013501:Surface-Active Agents