[Cell growth inhibitory substance isolated from Panax ginseng root: panaxytriol].
A new type of cell growth inhibitory substance was isolated and purified from a powder of the root of Panax ginseng C.A. Meyer, which has been commonly used for the treatment of various disease as a commercial medical drug by the name of Korean Red Ginseng Powder. Data from the infrared spectra, proton and carbon-13 nuclear magnetic resonance, and high resolution mass spectra were identical with those of authentic panaxytriol. Cell growth inhibition by panaxytriol seemed to be tumor-specific. Its action was supposed to be more dose-dependent than time-dependent. In vivo antitumor efficacy of panaxytriol was tested against C57BL/6 mice transplanted with B 16 melanomas. Panaxytriol (40 mg/kg) administered intramuscularly produced significant tumor growth delays in mice (p less than 0.01).
Katano
M
M
Dept. of Surgery, Saga Medical School.
Yamamoto
H
H
Matsunaga
H
H
Mori
M
M
Takata
K
K
Nakamura
M
M
D000480:Alkynes; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D053281:Enediynes; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology*; D006131:Growth Inhibitors; D006801:Humans; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation; D005894:Panax / Q000032:analysis*; D010946:Plants, Medicinal
D000480:Alkynes; D053281:Enediynes; D005233:Fatty Alcohols; D006131:Growth Inhibitors; C057682:panaxytriol