title: Effect of the secretions from the IUD-bearing uterus on peri-implantation mouse embryos.
abstract: This study was performed to evaluate the effect of IUD-bearing uterine secretions on peri-implantation mouse embryo. 83% of blastocysts degenerated by 96 hr after co-culture with uterine fluids from the IUD-bearing uterus. This degeneration rate was contrasted to 78% after heat treatment (56 degrees C for 30 min) of the IUD-bearing uterine secretions. These results suggest that embryotoxic agents are present in the fluid of the IUD-bearing uterus, especially in the supernatant component and that these agents may be related to the presence of macrophage or a chemical mediator produced by macrophage.
authors.affiliation: Dept. of Obstet. & Gynec., Faculty of Medicine, Kagoshima Univ., Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Sonoda
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D015237:Dinoprost / Q000096:biosynthesis; D015232:Dinoprostone / Q000096:biosynthesis; D047108:Embryonic Development; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D007434:Intrauterine Devices; D007958:Leukocyte Count; D051379:Mice; D008813:Mice, Inbred ICR; D009924:Organ Culture Techniques; D011247:Pregnancy; D014327:Trophoblasts / Q000187:drug effects; D014599:Uterus / Q000378:metabolism*
chemical_list: D015237:Dinoprost; D015232:Dinoprostone