Tumorigenesis by a long wavelength UV-A source.
Albino hairless mice (Skh-hr1) were exposed daily to radiation from a high-power long wavelength UV-A source (wavelengths longer than 340 nm). The irradiations lasted 2 h per day. The daily dose was 220 kJ/m2. Heavy scratching marks were observed in 13 out of 48 animals. However during the experiment 31 of the animals developed tumors of 1 mm or larger before any scratching was observed. The median induction time was 265 days for 1 mm tumors.
Sterenborg
H J
HJ
Laser Centre Academic Hospital, University of Amsterdam, The Netherlands.
van der Leun
J C
JC
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*; D014466:Ultraviolet Rays