The malignancy grading method is not a reliable assessment of malignancy in mesothelioma.
The ploidy of a series of pleural lesions--reactive proliferations, malignant mesotheliomas and metastatic tumours--was measured on a Leitz Miamed DNA image analyser using Feulgen-stained slides. The technique successfully recognized all the metastatic tumours as malignant; this corresponds to previous work. However, it was not successful in classifying mesothelial lesions as benign or malignant, resulting in a very high false-negative rate and a moderately high false-positive rate. Mesothelial lesions appear to have a wide range of ploidy values irrespective of their biological behaviour. Thus, for primary mesothelial tumours, the ploidy value cannot be used as a reliable diagnostic index.
Tierney
G
G
Department of Histopathology, University Hospital, Nottingham, U.K.
Wilkinson
M J
MJ
Jones
J S
JS
D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D011003:Ploidies