Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder.
One hundred and forty-five first-degree relatives (89 parents [96%] and 56 siblings [98%]) of 46 children and adolescents with severe primary obsessive compulsive disorder (OCD) were personally interviewed with clinical and structured psychiatric interviews. Parent interviews were scored by a rater blind to proband diagnosis. Thirty percent of probands had at least one first-degree relative with OCD: 25% of fathers and 9% of mothers received this diagnosis. Forty-five percent of fathers and 65% of mothers received one or more other psychiatric diagnoses. The increased familial rate of OCD over that expected from a general population, and over that found in parents of conduct disordered patients, is consistent with a genetic factor in OCD. Presenting obsessive compulsive symptoms of probands and their parents were usually dissimilar, arguing against any simple social or cultural transmission.
Lenane
M C
MC
Child Psychiatry Branch, NIMH, Bethesda, MD 20892.
Swedo
S E
SE
Leonard
H
H
Pauls
D L
DL
Sceery
W
W
Rapoport
J L
JL
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors