A model of the stimulation of a nerve fiber by electromagnetic induction.
A model is presented to explain the physics of nerve stimulation by electromagnetic induction. Maxwell's equations predict the induced electric field distribution that is produced when a capacitor is discharged through a stimulating coil. A nonlinear Hodgkin-Huxley cable model describes the response of the nerve fiber to this induced electric field. Once the coil's position, orientation, and shape are given and the resistance, capacitance, and initial voltage of the stimulating circuit are specified, this model predicts the resulting transmembrane potential of the fiber as a function of distance and time. It is shown that the nerve fiber is stimulated by the gradient of the component of the induced electric field that is parallel to the fiber, which hyperpolarizes or depolarizes the membrane and may stimulate an action potential. Finally, it predicts complicated dynamics such as action potential annihilation and dispersion.
Roth
B J
BJ
Division of Research Services, National Institutes of Health, Bethesda, MD 20892.
Basser
P J
PJ
D000200:Action Potentials; D004558:Electric Stimulation / Q000379:methods*; D055590:Electromagnetic Phenomena; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology*; D011930:Reaction Time