[Is the progesterone test a generalizable method of screening for neoplastic and preneoplastic lesions of the endometrium?].
A "progesterone test" has recently been proposed as a tentative method to detect early neoplastic and pre-neoplastic lesions of the uterus endometrium. At the time progesterone is stopped, a "deprivation" metrorragia demonstrates a remanent hyperoestrogenism, which represents a well-known risk factor for this type of lesion. The method has been evaluated in private practice; 389 patients were offered the test: 87% accepted. Metrorragias were observed in 28% of the cases; however, no neoplastic nor pre-neoplastic lesions could be detected in this group of patients. Moreover, one patient presented with an advanced endometrial cancer one year after a negative test. The reliability of such a test clearly needs further evaluation.
Viel
A
A
Médecins généralistes, Manche, France.
Goriaux
J L
JL
Rouge
J C
JC
Crouet
H
H
Héron
J F
JF
D000368:Aged; D005260:Female; D006801:Humans; D008234:Lynestrenol / Q000494:pharmacology; D008403:Mass Screening / Q000191:economics; D008593:Menopause; D008796:Metrorrhagia / Q000209:etiology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000628:therapy; D014594:Uterine Neoplasms / Q000517:prevention & control*
D008234:Lynestrenol
Le "test à la progestérone" est-il la méthode généralisable de dépistage des lésions néoplasiques et prénéoplasiques de l'endomètre?