Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation.
Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately.
Baumgart
E
E
Department of Anatomy and Cell Biology II, University of Heidelberg, FRG.
Völkl
A
A
Pill
J
J
Fahimi
H D
HD
D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology*; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D010084:Oxidation-Reduction; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013261:Sterols / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D000960:Hypolipidemic Agents; D010879:Piperazines; D013261:Sterols; D014280:Triglycerides; C047457:BM 15766; D002374:Catalase; D002332:Carnitine O-Acetyltransferase; D001629:Bezafibrate