Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta extracts on the central nervous system.
We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both extracts significantly reduced rectal temperature, spontaneous motor activity, and time on the Rota-rod and increased the number of mice falling off the rod before 180 s, but neither protected against pentylenetetrazole-induced convulsions or against oxotremorin-induced tremor, salivation, and diarrhoea.
Laguna
M R
MR
Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Galiza, Spain.
Villar
R M
RM
Cadavid
I
I
Calleja
J M
JM
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D016009:Chi-Square Distribution; D056890:Eukaryota / Q000032:analysis*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains