title: Hyperlipidaemia increases albuminuria in hypertensive and normotensive rats.
abstract: 1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total-cholesterol and a decrease in HDL-cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol-fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.
authors.affiliation: Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia.
authors.forename: M E
authors.initials: ME
authors.lastname: Cooper
authors.forename: D A
authors.initials: DA
authors.lastname: Vranes
authors.forename: S
authors.initials: S
authors.lastname: Panagiotopoulos
authors.forename: T J
authors.initials: TJ
authors.lastname: Allen
authors.forename: I
authors.initials: I
authors.lastname: Goodall
authors.forename: G
authors.initials: G
authors.lastname: Jerums
mesh_terms: D000419:Albuminuria / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000009:adverse effects / Q000097:blood*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors; D015430:Weight Gain
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL