Induction of glutathione-S-transferase isoenzymes by protein A in rat liver.
The administration of Protein A, a cell wall protein of Staphylococcus aureus Cowan I cells, causes an induction of glutathione-s-transferase in rat liver. Proteins, cross reactive with anti human glutathione-s-transferase, acidic (pi), basic (alpha, and neutral (mu) isoenzymes, are induced by 5.8, 2.2 and 6.15 fold respectively. The induction of glutathione -s-transferases, at least in part, might play a role in manifestation of therapeutic properties of Protein A.
Dwivedi
P P
PP
Industrial Toxicology Research Centre, Lucknow, India.
Kumar
A
A
Prasad
A K
AK
Pandya
K P
KP
Ray
P K
PK
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction; D005982:Glutathione Transferase / Q000096:biosynthesis*; D015151:Immunoblotting; D007527:Isoenzymes / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013205:Staphylococcal Protein A / Q000494:pharmacology*
D007527:Isoenzymes; D013205:Staphylococcal Protein A; D005982:Glutathione Transferase