Induction of labor in intrauterine fetal death with 16-phenoxy-prostaglandin-E2-methylsulfonylamide (sulprostone)--effects on uterine contractility, coagulation and kallikrein-kinin systems.
Thirty-two patients with intrauterine fetal death after the 20th week of pregnancy were treated with 1-3 intramuscular injections of 500 mg of 16-phenoxy-PGE2-methylsulfonylamide (sulprostone). Intrauterine pressure records demonstrated onset of contractions within 20 min of injection and all women aborted-delivered after in mean 11 h (4-31 h). No effect on routine hematologic and plasma parameters, kallikrein-kinin and factor XII systems was observed. It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system.
Laudański
T
T
Department of Obstetrics and Gynecology, University of Bialystok, Poland.
Litorowicz
A
A
Akerlund
M
M
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005313:Fetal Death; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D007705:Kinins / Q000187:drug effects*; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics; D014590:Uterine Contraction / Q000187:drug effects*
D007705:Kinins; D010120:Oxytocics; C016767:sulprostone; D007610:Kallikreins; D015232:Dinoprostone