Dynamic training and circulating levels of corticotropin-releasing factor, beta-lipotropin and beta-endorphin in rheumatoid arthritis.
The study aimed at evaluating the effects of a dynamic training program on circulating levels of corticotropin-releasing factor (CRF), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EP) in 8 patients (5 females and 3 males, aged 39-65 years) with classical/definite rheumatoid arthritis (RA). Blood samples were collected immediately before, in the middle of, and after a 6-week high-intensity training period as well as after a subsequent 1-year period of low-intensity training. In addition, baseline data were obtained 3 weeks before the start of the training program. Use of multivariate analyses of variance, and of analyses of variance of contrast variables, indicated a short-term effect of the high-intensity training program for beta-EP with increased levels (P less than 0.05) between the 3rd and the 6th weeks, no significant differences being obtained for CRF or beta-LPH here. Corresponding analyses with regard to the combined high and low-intensity training program revealed CRF (P less than 0.01), and beta-LPH (P less than 0.01) levels to increase over time, no long-term effect being found for beta-EP. Despite the intensity of the dynamic training program, no change was found in pain experience as measured on a visual analogue scale.
Ekdahl
Charlotte
C
Lund University Health Sciences Centre, S-240 10 DalbySweden Department of Psychiatry and Neurochemistry, Lund University, 5-220 06 LundSweden Section of Rheumatology, Department of Medicine, Nya Lasarettet, S-251 87 HelsingborgSweden.
Ekman
Rolf
R
Andersson
Sven Ingmar
SI
Melander
Arne
A
Svensson
Björn
B
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000628:therapy; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D004723:Endorphins / Q000097:blood*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008083:beta-Lipotropin / Q000097:blood*
D004723:Endorphins; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin