title: Comparative in vitro activities of several new fluoroquinolones and beta-lactam antimicrobial agents against community isolates of Streptococcus pneumoniae.
abstract: The in vitro susceptibilities of 551 community isolates of Streptococcus pneumoniae from the Canadian province of Ontario to several new fluoroquinolones and beta-lactam antimicrobial agents were determined by a broth microdilution technique. Eight (1.5%) of these isolates were moderately susceptible (MICs, greater than or equal to 0.12 and less than or equal to 1.0 microgram/ml) to penicillin; none was resistant. Temafloxacin, ciprofloxacin, and ofloxacin (MICs for 90% of strains tested, between 1 and 2 micrograms/ml) were the most active fluoroquinolones tested, and BMY-28100 (MIC for 90% of strains tested, 0.25 microgram/ml) was the most active of the new beta-lactams tested.
authors.affiliation: Department of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Mazzulli
authors.forename: A E
authors.initials: AE
authors.lastname: Simor
authors.forename: R
authors.initials: R
authors.lastname: Jaeger
authors.forename: S
authors.initials: S
authors.lastname: Fuller
authors.forename: D E
authors.initials: DE
authors.lastname: Low
mesh_terms: D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D047090:beta-Lactams
chemical_list: D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D047090:beta-Lactams