title: Structures of paralytic acylpolyamines from the spider Agelenopsis aperta.
abstract: The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties.
authors.affiliation: Sandoz Crop Protection Corporation, Palo Alto, California 94304.
authors.forename: G B
authors.initials: GB
authors.lastname: Quistad
authors.forename: S
authors.initials: S
authors.lastname: Suwanrumpha
authors.forename: M A
authors.initials: MA
authors.lastname: Jarema
authors.forename: M J
authors.initials: MJ
authors.lastname: Shapiro
authors.forename: W S
authors.initials: WS
authors.lastname: Skinner
authors.forename: G C
authors.initials: GC
authors.lastname: Jamieson
authors.forename: A
authors.initials: A
authors.lastname: Lui
authors.forename: E W
authors.initials: EW
authors.lastname: Fu
mesh_terms: D000818:Animals; D001180:Arthropod Venoms / Q000032:analysis*; D006898:Hydroxylamines / Q000032:analysis* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010243:Paralysis / Q000139:chemically induced; D011073:Polyamines / Q000032:analysis* / Q000633:toxicity; D013111:Spider Venoms / Q000032:analysis* / Q000633:toxicity
chemical_list: D001180:Arthropod Venoms; D006898:Hydroxylamines; D011073:Polyamines; D013111:Spider Venoms