[The effect of gamma-aminobutyric acid at the somatic and dendritic level in Purkinje cells in the cerebellum of the frog in vitro].
The effect of gamma-aminobutyric acid (GABA) on its receptors localized on the somatic and dendritic membrane of Purkinje cells was tested on the isolated cerebellum of the frog. The action of GABA was found to be different in the two zones studied. On the membrane of the cell bodies GABA inhibited the overall synaptic potential and spontaneous activity by a mechanism dependent on increased Cl- conductivity resulting in hyperpolarization of the somatic membrane. On the dendritic membrane the inhibitory effect of GABA on the spontaneous activity of dendrites was only minimal and shortlasting. At intradendritic recording a depolarizing effect of GABA was observed whose mechanism is so far unknown.
Strauss
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Centra fyziologických vied SAV v Bratislave.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology; D011893:Rana esculenta; D011896:Rana temporaria; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid
Pôsobenie kyseliny gamaaminomaslovej na somatickej a dendritickej úrovni Purkynových buniek mozocka zaby in vitro.