In vitro activity of protoanemonin, an antifungal agent.
Protoanemonin, the lactone of gamma-hydroxy-vinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 micrograms/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg.
Martín
M L
ML
Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Spain.
San Román
L
L
Domínguez
A
A
D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000032:analysis*
D000935:Antifungal Agents; D005663:Furans; C037354:protoanemonin