title: Safety and efficacy of two sustained-release intrareticular selenium supplements and the associated placental and colostral transfer of selenium in beef cattle.
abstract: One hundred fifty Se-deficient, pregnant, crossbred beef cows were assigned to 1 of 4 treatment groups: group A, Se-deficient control; group B, 1 Se bolus at 0 and 119 days; group C, 1 Se bolus at 0 days; and group D, 2 Se pellets at 0 days. The Se bolus is an osmotic pump designed to release 3 mg of Se/d into the reticulorumen. The Se pellets weight approximately 30 g and contain 10% elemental Se, which is liberated in the reticulorumen. The Se bolus is designed to provide Se supplementation for 120 days and the Se pellets provide supplementation for up to 18 months. Cattle were maintained on Se-deficient pasture or forages prepared from these pastures for the duration of the experiment. Blood samples were collected from cows prior to treatment (time 0) and at 28, 52, 119, and 220 days thereafter and analyzed for blood Se (BSe) concentration. Body weights were recorded at each sampling time. Blood Se concentration of cows from all supplemented groups were significantly (P less than 0.01) higher than control values at all sample dates after treatments began. By the end of the 220-day study, treatment group-B cattle had significantly (P less than 0.01) higher BSe concentrations than any other group. Body weights of treatment groups fluctuated throughout the study, but did not differ (P greater than 0.05) between groups. One cow and 6 calves born to cows during the experimental period died. Necropsy of 5 calves provided no evidence linking these deaths to treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: College of Veterinary Medicine, Oregon State University, Corvallis 97331.
authors.forename: D T
authors.initials: DT
authors.lastname: Campbell
authors.forename: J
authors.initials: J
authors.lastname: Maas
authors.forename: D W
authors.initials: DW
authors.lastname: Weber
authors.forename: O R
authors.initials: OR
authors.lastname: Hedstrom
authors.forename: B B
authors.initials: BB
authors.lastname: Norman
mesh_terms: D000818:Animals; D002417:Cattle / Q000097:blood*; D003126:Colostrum / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011897:Random Allocation; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage* / Q000172:deficiency / Q000378:metabolism; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D012643:Selenium