title: [The effect of elevated blood glucose levels and body weight on the metabolic profile in type 2 diabetes after long-term therapy].
abstract: Based on an analysis of data obtained in a group of 145 men and women with type 2 diabetes perssiting for 10.1 +/- 6.6 years who were hospitalized on account of unsatisfactory compensation of diabetes, the authors provided evidence that the fasting blood sugar level is associated with a reduced response of C peptide to an alimentary stimulus, while the excessive weight of the patients has a bearing on the elevated concentration of C peptide on fasting and causes their insulin resistance. The body weight has a bearing on the level of risk factors, i.e. HDL cholesterol, uric acid and in women also triacylglycerols. The elevated blood sugar level influences in a mirror image manner the sodium and potassium level. The relations between the blood sugar level and glomerular filtration draw attention to the interference with the water economy even at blood sugar levels which are still tolerated. The trend of rising potassium levels must be foreseen in case of a poor compensation even in case of insulin treatment of diabetes. The risk of elevated potassium should be taken into account also with regard to indications of antihypertensive treatment. The authors also draw attention to the need of acloser compensation of type 2 diabetes. Early adjustment of the energy metabolism in diabetics deserves priority. When insulin treatment is needed, the all-day requirement should be met by 2-3 doses.
authors.affiliation: Institut klinické a experimentálni medicíny, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Válek
authors.forename: Z
authors.initials: Z
authors.lastname: Vlasáková
authors.forename: J
authors.initials: J
authors.lastname: Pelikánová
authors.forename: I
authors.initials: I
authors.lastname: Karasová
authors.forename: A
authors.initials: A
authors.lastname: Jirkovská
authors.forename: D
authors.initials: D
authors.lastname: Grafnetter
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology / Q000628:therapy; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D004573:Electrolytes; D008055:Lipids; D014508:Urea
vernacular_title: Vliv zvýseného krevního cukru a hmotnosti na metabolický profil dlouhodobĕ léceného diabetu 2. typu.