Amplitudes of somatosensory evoked potentials reflect cortical hyperexcitability in antidepressant-induced myoclonus.
During treatment with therapeutic dosages of cyclic antidepressants, 2 patients experienced reversible myoclonus. These episodes were accompanied by enlarged cortical somatosensory evoked potentials (SEP). We suggest that SEP amplitudes reflect modifications of cortical excitability during antidepressant treatment.
Förstl
H
H
Central Institute of Mental Health, Mannheim, West Germany.
Pohlmann-Eden
B
B
D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D009207:Myoclonus / Q000139:chemically induced* / Q000503:physiopathology
D000929:Antidepressive Agents, Tricyclic