Concentrations of ampicillin in human serum and mixed saliva following a single oral administration of lenampicillin, and relationship between serum and mixed saliva concentrations.
The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060 micrograms/ml, respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r = 0.71, P less than 0.001, was found.
Akimoto
Y
Y
Second Department of Oral Surgery, Nihon University School of Dentistry, Matsudo, Japan.
Mochizuki
Y
Y
Uda
A
A
Omata
H
H
Shibutani
J
J
Nishimura
H
H
Komiya
M
M
Kaneko
K
K
Kobayashi
S
S
Kuboyama
N
N
D000284:Administration, Oral; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood*; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis*
D000667:Ampicillin; C045384:lenampicillin