title: Sulphamethoxazole acetylation in fast and slow acetylators.
abstract: Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
authors.affiliation: Department of Pharmacology, University of Hacettepe, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
authors.forename: N E
authors.initials: NE
authors.lastname: Basci
authors.forename: A
authors.initials: A
authors.lastname: Isimer
authors.forename: M
authors.initials: M
authors.lastname: Tuncer
authors.forename: R
authors.initials: R
authors.lastname: Erdal
authors.forename: S O
authors.initials: SO
authors.lastname: Kayaalp
mesh_terms: D000107:Acetylation; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism; D013420:Sulfamethoxazole / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D013418:Sulfamethazine; D013420:Sulfamethoxazole