title: Effect of Crataeva nurvala in experimental urolithiasis.
abstract: The effect of oral administration of Crataeva nurvala bark decoction on calcium oxalate lithiasis has been studied in rats. The elevation of the oxalate-synthesizing liver enzyme, glycolate oxidase, produced by feeding glycollic acid was remarkably reduced with the decoction, showing a regulatory action on endogenous oxalate synthesis. Protein-bound carbohydrates were increased in the renal tissues during calculosis but these changes were not reversed with the herbal treatment. The increased deposition of stone-forming constituents in the kidneys of calculogenic rats was lowered with decoction administration. The increased urinary excretion of the crystalline constituents along with lowered magnesium excretion found in stone-forming rats was partially reversed by decoction treatment.
authors.affiliation: Department of Medical Biochemistry, Madras University, Taramani, India.
authors.forename: P
authors.initials: P
authors.lastname: Varalakshmi
authors.forename: Y
authors.initials: Y
authors.lastname: Shamila
authors.forename: E
authors.initials: E
authors.lastname: Latha
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002129:Calcium Oxalate / Q000032:analysis; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007669:Kidney Calculi / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010936:Plant Extracts; D002129:Calcium Oxalate