Experimental tissue damage after subcutaneous injection of water soluble contrast media.
Various water soluble contrast media (WSCM) were injected subcutaneously into 970 hind feet of 485 rats. Gross morphologic changes were seen after the injection and analyzed as a function of various physicochemical characteristics of WSCM. The WSCM of larger volume, higher osmolality, higher iodine content, and meglumine salts rather than sodium salts caused more severe tissue damage; younger rats showed more severe tissue damage by WSCM of high osmolality.
Kim
S H
SH
Department of Radiology, Seoul National University, Korea.
Park
J H
JH
Kim
Y I
YI
Kim
C W
CW
Han
M C
MC
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D007279:Injections, Subcutaneous; D007472:Iohexol / Q000633:toxicity / Q000031:analogs & derivatives; D007479:Iopamidol / Q000633:toxicity; D007483:Iothalamic Acid / Q000633:toxicity / Q000031:analogs & derivatives; D007485:Ioxaglic Acid / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000473:pathology*
D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D007472:Iohexol; C038192:iopromide; C002587:ioxitalamic acid; D007479:Iopamidol; D007485:Ioxaglic Acid