Bronchopulmonary dysplasia: a correlative study by light, scanning, and transmission electron microscopy.
The sequential stages of bronchopulmonary dysplasia occurring in 18 infants after intensive respiratory therapy supplemented by oxygen in high concentrations were studied by correlative light, scanning, and transmission electron microscopy. Infant survival ranged from 3 to 225 days. The earliest stage was an exudative reaction with a predominance of hyaline membranes. This merged with a subacute reparative response that was replaced by a chronic fibroproliferative stage in infants of longest survival; this stage was complicated by pulmonary fibrosis and emphysema. Correlative scanning and transmission electron microscopy demonstrated that type 2 pneumocytes contributed significantly to the reparative fibroproliferative response by organization of hyaline membranes and reepithelialization of damaged septal walls.
Anderson
W R
WR
Department of Pathology, Hennepin County Medical Center, Minneapolis, MN 55415.
D001980:Bronchi / Q000473:pathology; D001997:Bronchopulmonary Dysplasia / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011650:Pulmonary Alveoli / Q000648:ultrastructure