[The effect of acetylsalicylic acid and dipyridamole on glomerular filtration and proteinuria in chronic glomerulonephritis].
The authors treated 14 patients with chronic proliferative glomerulonephritis for one year with acetylsalicylic acid--400 mg/day--and dipyridamole--225 mg/day. They investigated changes of glomerular filtration and proteinuria before treatment, during treatment and one year after its completion. They found that in the course of treatment proteinuria did not change and glomerular filtration declined insignificantly. During the subsequent year proteinuria and glomerular filtration declined significantly. The above findings can be partly explained by changes in the synthesis of renal prostacyclin and thromboxane. The combination of acetylsalicylic acid and dipyridamole in the amounts used did not have a favourable effect on glomerular filtration in patients with chronic proliferative glomerulonephritis.
Nĕmecek
K
K
II. interní katedra fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Petrů
I
I
Knotková
V
V
Jáchymová
M
M
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D002908:Chronic Disease; D004176:Dipyridamole / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D015432:Glomerulonephritis, Membranoproliferative / Q000503:physiopathology* / Q000652:urine; D006801:Humans; D008297:Male; D011507:Proteinuria
D004176:Dipyridamole; D001241:Aspirin
Vliv kyseliny acetylosalicylové a dipyridamolu na glomerulární filtraci a proteinurii u chronické glomerulonefritidy.