Infant acute lymphoblastic leukaemia with t(11; 19).
Seven cases of infant acute lymphoblastic leukaemia with t(11; 19) (q23; p13) are described. They are characterized by a high white cell count, organomegaly, early central nervous system (CNS) disease, and a poor prognosis. Blasts are usually of an immature early B-cell lineage although monocytoid features are present in some cases. The characteristics of infant acute leukaemia with t(11; 19) are very similar to those found with t(4; 11), and the presence of t(11; 19) may indicate the same poor prognosis.
Gibbons
B
B
CRF Department of Medical Oncology, St. Bartholomew's Hospital, London.
Katz
F E
FE
Ganly
P
P
Chessells
J M
JM
D000951:Antigens, Neoplasm / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007958:Leukocyte Count; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*
D000951:Antigens, Neoplasm