Microtransferrinuria and microalbuminuria. II. In the rat.
We studied albumin and transferrin excretion in the normal and diabetic rat: (1) The rat secretes small concentrations of albumin and transferrin in the urine. (2) The secretion depends on the strain and was highest in the Kyoto spontaneously hypertensive rat. (3) The secretion of these two proteins in the rat is quite dependent on age and sex. The level increases dramatically with age. The secretion is much higher in the male compared to the female. This difference is observed after puberty. The changes in transferrin relative to those in albumin are much higher. (4) In streptozotocin-induced diabetes, the concentration of albumin and transferrin expressed as milligrams per liter decreases; however, the output/24 h or per gram creatinine is increased with a greater increase in transferrin output relative to that of albumin. The similarities and differences between excretion of these two proteins in the human and the rat as well as their importance are discussed.
McCormick
C P
CP
Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, N.C.
Shihabi
Z K
ZK
Konen
J C
JC
Goodman
H O
HO
Blizard
D A
DA
D000375:Aging / Q000378:metabolism; D000419:Albuminuria / Q000652:urine*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000652:urine*; D007668:Kidney / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012737:Sex Factors; D014168:Transferrin / Q000652:urine*
D014168:Transferrin