Nifedipine overdose accompanied by ethanol intoxication in a patient with congenital heart disease.
A 34-year-old female was brought to the emergency department after taking 200 to 250 mg of nifedipine and drinking an unknown amount of ethanol in a suicide attempt. She was hypotensive, acidotic, mildly hyperglycemic, and exhibited a conduction abnormality on the ECG. The patient was treated with IV fluids, thiamine, and calcium infusion. The patient was later found to have an endocardial cushion defect with a patched ventricular septal defect and an atrial septal defect of the ostium primum type. We did not observe any untoward effects due to the combination of drugs and congenital abnormalities that could be explained on an individual basis. Nifedipine overdose associated with alcohol intoxication, to our knowledge, has not been previously reported.
Welch
R D
RD
Department of Surgery, Wayne State University School of Medicine, Detroit, MI.
Todd
K
K
D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications*; D062787:Drug Overdose / Q000150:complications / Q000175:diagnosis; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications; D006801:Humans; D009543:Nifedipine / Q000008:administration & dosage / Q000506:poisoning*
D009543:Nifedipine