title: A reduced-modulus acrylic bone cement: preliminary results.
abstract: Excessive local contact stress is implicated as an important factor in the initiation of the loosening process after total joint arthroplasties. A reduced-modulus acrylic bone cement, which decreases the bone-cement interface stresses, was developed to test this hypothesis. The formulation consists of butylmethacrylate beads, having a glass transition temperature of 27 degrees C, in a methylmethacrylate matrix. This cement, polybutylmethylmethacrylate (PBMMA), has an elastic modulus one-eighth that of standard PMMA bone cement, 0.27 vs. 2.1 GPa, at body temperature. In vivo use in a pilot study using the sheep total hip arthroplasty model shows a reduction in the rate of loosening of femoral components when compared both radiographically and mechanically with PMMA controls.
authors.affiliation: Orthopaedic BioMaterials Laboratory, Ohio State University, Columbus.
authors.forename: A S
authors.initials: AS
authors.lastname: Litsky
authors.forename: R M
authors.initials: RM
authors.lastname: Rose
authors.forename: C T
authors.initials: CT
authors.lastname: Rubin
authors.forename: E L
authors.initials: EL
authors.lastname: Thrasher
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements; D001847:Bone Diseases / Q000628:therapy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D005260:Female; D008954:Models, Biological; D011859:Radiography; D012756:Sheep; D013314:Stress, Mechanical; D014102:Torsion Abnormality
chemical_list: D000180:Acrylic Resins; D001843:Bone Cements