title: The pattern of depressive symptoms varies with progression of Parkinson's disease.
abstract: Whether or not depressive symptoms increase in severity with progression of Parkinson's disease (PD) remains uncertain. Unlike previous studies, we examined whether the severity of specific features of depression (mood, self reproach, vegetative, and somatic symptoms) differ with respect to the progression of PD. Results indicated that symptoms related to both mood and self-reproach were present in the early stages of PD but did not increase in severity with advancing disease. Somatic features of depression were evident early and increased with disease progression, and vegetative symptoms were seen only in the later stages of PD. The different patterns of these depressive features with progression of PD may account in part for the variations seen in previous studies.
authors.affiliation: Department of Neurology, College of Medicine, Ohio State University, Columbus 43210.
authors.forename: S J
authors.initials: SJ
authors.lastname: Huber
authors.forename: D L
authors.initials: DL
authors.lastname: Freidenberg
authors.forename: G W
authors.initials: GW
authors.lastname: Paulson
authors.forename: E C
authors.initials: EC
authors.lastname: Shuttleworth
authors.forename: J A
authors.initials: JA
authors.lastname: Christy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index