title: Theoretical determination of the current density distributions in human vertebral bodies during electrical stimulation.
abstract: Electrical stimulation with a 60 kHz sinewave input signal, supplied via external plate electrodes on the skin surface, is presently being studied as a treatment for human systemic osteoporosis. In this paper, Maxwell's equations were solved for voltage and current density values at nodal points in a three-dimensional, anatomically-based, finite element grid model of the human trunk constructed from T5 to L5. Based on the dose response results from Luessenhop's castrated Sprague Dawley breeder rat experiment and our theoretical determination, the magnitude of the input current to the electrodes necessary to induce a response in the human vertebral body was determined. Four different electrode systems in current clinical use were evaluated, and the optimal input current determined. In addition, the effect of subcutaneous fat was studied.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia 19140.
authors.forename: E L
authors.initials: EL
authors.lastname: Carter
authors.forename: S R
authors.initials: SR
authors.lastname: Pollack
authors.forename: C T
authors.initials: CT
authors.lastname: Brighton
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D015519:Bone Density / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D008954:Models, Biological; D013131:Spine / Q000000981:diagnostic imaging / Q000502:physiology*; D013904:Thoracic Vertebrae / Q000502:physiology; D014057:Tomography, X-Ray Computed