[Etoposide delivery to malignant brain tumors by induced hypertension with angiotensin II].
Etoposide delivery to 9L gliosarcoma model in Fischer 344 rats was evaluated. Etoposide 2 mg/body was given intravenously (IV) or intracarotidly with (IHIC) or without (IC) intravenously administrated angiotensin II. Mean etoposide concentration of tumors was 5.08 micrograms/g for IHIC group, 2.27 micrograms/g for IC group and 0.70 micrograms/g for IV group. The difference in etoposide concentration between IHIC group and IV group was statistically significant (p less than 0.05). In addition, etoposide concentrations of the normal brain tissues were lower than concurrent plasma concentrations in all groups. The etoposide concentration was increased in the tumor and very low in the normal brain tissues in Fischer 344 rats with 9L gliosarcoma by induced hypertension with angiotensin II. These studies might suggest that intraarterial chemotherapy by induced hypertension with angiotensin II was useful on treatment of malignant brain tumors.
Ogasawara
H
H
Dept. of Neurosurgery, Hiroshima University School of Medicine.
Kurisu
K
K
Mikami
T
T
Hotta
T
T
Sugiyama
K
K
Kiya
K
K
Uozumi
T
T
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D002343:Carotid Artery, Internal; D005047:Etoposide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D007261:Infusions, Intra-Arterial; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000804:Angiotensin II; D005047:Etoposide