Pharmacokinetic aspects of the sublingual administration of vincamine.
The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.
Aiache
J M
JM
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Delatte
M C
MC
Leblanc
P P
PP
Kantelip
J P
JP
Gomeni
R
R
Steimer
J L
JL
D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D011897:Random Allocation; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*; D014749:Vincamine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D014748:Vinca Alkaloids; D014749:Vincamine