Assembly of type I collagen fibrils de novo by the specific enzymic cleavage of pC collagen. The fibrils formed at about 37 degrees C are similar in diameter, roundness, and apparent flexibility to the collagen fibrils seen in connective tissue.
Kadler
K E
KE
Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Hulmes
D J
DJ
Hojima
Y
Y
Prockop
D J
DJ
D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism* / Q000648:ultrastructure; D003238:Connective Tissue / Q000378:metabolism* / Q000648:ultrastructure; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D011347:Procollagen / Q000302:isolation & purification / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
D046911:Macromolecular Substances; D011347:Procollagen; D003094:Collagen