[The effect of anisodamine on lipoprotein metabolism in the liver and the plasma membrane phospholipids of the hepatocytes in hemorrhagic shock].
The effect of anisodamine on lipoprotein metabolism in the liver and hepatocyte membrane phospholipids was studied on a model of hemorrhagic shock. Preliminary injection of anisodamine raised the content of very low-density lipoproteins in blood of the central vessels and intensified the breakdown of low-density lipoproteins in the liver. The main changes in the phospholipid composition of the hepatocyte plasma membranes in hemorrhagic shock are associated with phosphatidylcholine and phosphatidylinositol. Decrease of the phosphatidylcholine content and increase of the phosphatidylinositol level were encountered. Anisodamine reduces the level of phosphatidylinositol in the hepatocyte plasma membranes and brings it close to normal.
Leskova
G F
GF
Su
L B
LB
Udovichenko
V I
VI
D000818:Animals; D002415:Cats; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000494:pharmacology; D008074:Lipoproteins / Q000187:drug effects* / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000378:metabolism; D012991:Solanaceous Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D008563:Membrane Lipids; D010743:Phospholipids; D012991:Solanaceous Alkaloids; C003922:anisodamine; D006493:Heparin
Vliianie anizodamina na obmen lipoproteidov v pecheni i fosfolipidy plazmaticheskikh membran gepatotsitov pri gemorragicheskom shoke.