Influence of ciclosporin on epidermal proliferation after mechanical skin irritation.
In mice (NMRI and hr/hr), ciclosporin, subcutaneously administered once daily over 7-10 days, influenced epidermal hyperproliferation induced by abrasion of superficial epidermal layers. While in vehicle-treated control animals the mechanical irritation of skin caused an increase in 3H-thymidine triphosphate incorporation rate into DNA and also in epidermal thickness of tail and flank skin, the hyperproliferative response was diminished in ciclosporin-treated animals. Thus, only a slight increase of the 3H-thymidine triphosphate incorporation rate and of epidermal thickness was measured after pretreatment with ciclosporin, the effect being dose-dependent. The strongest inhibitory activity was found after application of 30 mg/kg BW. These findings indicate that the immunosuppressive peptide ciclosporin inhibits the epidermal proliferation in vivo.
Kietzmann
M
M
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Hochschule, Hannover, BRD.
Lubach
D
D
Wonigeit
K
K
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003524:Cyclosporins / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000293:injuries* / Q000473:pathology; D013936:Thymidine / Q000378:metabolism
D003524:Cyclosporins; D013936:Thymidine