title: Single photon emission computed tomography with technetium-99m hexamethyl propylenamino oxime in the pain-free interval of migraine and cluster headache.
abstract: Thirty-three headache-free patients (19 F/14 M) suffering from common (n = 9) and classic migraine (n = 19) as well as cluster headache (n = 5) were investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime and single photon emmission computed tomography. A regional decrease of cerebral tracer uptake was observed in 16 patients with common migraine, but only in 3 patients with classic migraine and in no patient with cluster headache. In 10 of 15 cases with hemiplegic symptoms during migraine attack the areas of decreased tracer uptake showed a topographic relationship to neurological deficits. It appears that migraine attacks occur in connection with exacerbations of preexisting changes of neuronal activities, cerebral perfusion and metabolism.
authors.affiliation: Department of Neurology, University of Münster, FRG.
authors.forename: H P
authors.initials: HP
authors.lastname: Schlake
authors.forename: I G
authors.initials: IG
authors.lastname: Böttger
authors.forename: K H
authors.initials: KH
authors.lastname: Grotemeyer
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
authors.forename: B
authors.initials: B
authors.lastname: Vollet
authors.forename: O
authors.initials: O
authors.lastname: Schober
authors.forename: G G
authors.initials: GG
authors.lastname: Brune
mesh_terms: D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation; D003027:Cluster Headache / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D014653:Vascular Headaches / Q000503:physiopathology*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime