Two-year carcinogenicity study of sodium fluoride in rats.
To determine the carcinogenic potential of sodium fluoride (NaF), we fed Sprague-Dawley rats a diet containing NaF for up to 99 weeks. Rats receiving NaF at a dose of 4, 10, or 25 mg/kg per day added to a low-fluoride diet were compared with controls receiving either a low-fluoride diet or laboratory chow. Each treatment group consisted of 70 rats of each sex. A 30% decrement in weight gain occurred at an NaF dose of 25 mg/kg per day. Evidence of fluoride toxicity was seen in the teeth, bones, and stomach, and the incidence and severity of these changes were related to the dose of NaF and the duration of exposure. Despite clear evidence of toxicity, NaF did not alter the incidence of preneoplastic and neoplastic lesions at any site in rats of either sex. Results from this study indicate that NaF is not carcinogenic in Sprague-Dawley rats.
Maurer
J K
JK
Procter and Gamble Co., Miami Valley Laboratories, Cincinnati, OH 45239-8707.
Cheng
M C
MC
Boysen
B G
BG
Anderson
R L
RL
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D015197:Carcinogenicity Tests; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000033:anatomy & histology; D005459:Fluorides / Q000652:urine; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012886:Skull / Q000187:drug effects; D012969:Sodium Fluoride / Q000009:adverse effects* / Q000633:toxicity; D013046:Specific Gravity; D013270:Stomach / Q000033:anatomy & histology; D013997:Time Factors; D014070:Tooth / Q000187:drug effects
D001786:Blood Glucose; D012969:Sodium Fluoride; D005459:Fluorides