Antinociceptive effect of taurine and its inhibition by naxolone.
1. We have tested the effect of taurine on nociceptive stimulation provoked by chemical agent (acetic acid) and by the hot-plate test. 2. In the acetic acid test, taurine exerts an antinociceptive effect at every dose and time assayed. The observed effect was dose-related. 3. Naxolone pretreatment antagonizes the antinociceptive effect of taurine in the acetic acid test. 4. The results obtained in hot-plate test show that taurine did not significantly affect latency time for paw licking.
Serrano
J S
JS
Department of Pharmacology, Seville University Medical School, Spain.
Serrano
M I
MI
Guerrero
M R
MR
Ruiz
R
R
Polo
J
J
D000085:Acetates; D019342:Acetic Acid; D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D011930:Reaction Time / Q000187:drug effects; D013654:Taurine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000085:Acetates; D000700:Analgesics; D013654:Taurine; D009270:Naloxone; D019342:Acetic Acid