Histopathological findings in the central and peripheral nervous systems in neuroborreliosis. A report of three cases.
Very little is known about tissue changes and pathophysiological mechanisms in Garin-Boujadoux-Bannwarth syndrome. We report histopathological findings in the central and peripheral nervous systems of three typical cases. In the acute stage of the disease mononuclear perivascular infiltrations with mainly T-helper cells were the prominent finding, whereas after treatment there was no vessel involvement. The fibre changes in the peripheral nervous system consisted of axonal degeneration. No Borrelia burgdorferi-specific antigen could be detected by immunohistochemical methods. Thus vasculitis might be one of the primary pathophysiological mechanisms for the involvement of the nervous system.
Meurers
B
B
Neurologische Universitätsklinik und Poliklinik, Würzburg, Federal Republic of Germany.
Kohlhepp
W
W
Gold
R
R
Rohrbach
E
E
Mertens
H G
HG
D000328:Adult; D000368:Aged; D001706:Biopsy; D002490:Central Nervous System / Q000473:pathology*; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*; D014657:Vasculitis / Q000209:etiology / Q000473:pathology