Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction.
Weiss
M
M
Department of Pharmacology and Toxicology, Martin Luther University, Halle-Wittenberg, Halle, German Democratic Republic.
D000042:Absorption; D000983:Antipyrine / Q000493:pharmacokinetics; D001682:Biological Availability; D002110:Caffeine / Q000493:pharmacokinetics; D004155:Diphenhydramine / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007650:Ketanserin / Q000493:pharmacokinetics; D008012:Lidocaine / Q000493:pharmacokinetics; D008107:Liver Diseases / Q000378:metabolism; D008795:Metronidazole / Q000493:pharmacokinetics; D009627:Nomifensine / Q000493:pharmacokinetics; D014223:Triamterene / Q000493:pharmacokinetics
D008795:Metronidazole; D009627:Nomifensine; D002110:Caffeine; D004155:Diphenhydramine; D007650:Ketanserin; D008012:Lidocaine; D000983:Antipyrine; D014223:Triamterene