[Cyclosporin A in preventive therapy after kidney transplantation: a double combination versus a triple combination. II. Adverse effects of cyclosporin A and therapeutic complications].
The incidence of irreversibly afunctional grafts, late functional development and period of the initial temporary lack of function did not differ in the two groups. The total number of nephrotoxic episodes was significantly (p less than 0.05) lower in the triple combination, chronic nephrotoxicity developed with equal frequency. Infectious complications were present in 54% of the patients in group A and in 60% in group B, viral complications in 15% patients in group A and in 16% in group B. Serious bacterial infections were the cause of death in one of three patients in group A and in five of six patients in group B.
Matl
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I
Program výzkumu transplantací orgánů, Institutu klinické a experimentální medicíny, Praha.
Jirka
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J
Kocandrle
V
V
Petrásek
R
R
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007239:Infections / Q000276:immunology; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation / Q000401:mortality; D008099:Liver / Q000187:drug effects; D008297:Male; D011241:Prednisone / Q000008:administration & dosage
D003524:Cyclosporins; D001379:Azathioprine; D011241:Prednisone
Cyklosporin A v profylaktické lécbĕ po transplantaci ledviny: dvojkombinace versus trojkombinace. II. Nezádoucí úcinky cyklosporinu A a komplikace lécby.