Substituted cyclic imides as potential anti-gout agents.
N-substituted cyclic imides of phthalimide, 2,3-dihydrohalazine-1,4-dione, and diphenimide were shown to reduce the serum uric acid levels in normal and hyperuric mice at 20 mg/kg/day I.P. for 14 days. The agents were potent inhibitors of commercial xanthine dehydrogenase and xanthine oxidase enzyme activities with IC50 values from 10(-7) to 10(-8) M concentrations of drug.
Hall
I H
IH
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, N.C. 27599.
Scoville
J P
JP
Reynolds
D J
DJ
Simlot
R
R
Duncan
P
P
D000493:Allopurinol / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000627:therapeutic use*; D007094:Imides / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D010797:Phthalimides / Q000494:pharmacology / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood*; D014968:Xanthine Dehydrogenase / Q000037:antagonists & inhibitors; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D006074:Gout Suppressants; D007094:Imides; D010797:Phthalimides; D014527:Uric Acid; D000493:Allopurinol; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase