title: Response to recombinant bovine somatotropin in dairy cows with different genetic merit for milk production.
abstract: Thirty-nine multiparous cows obtained from two genetic lines were utilized to determine the effect of genetic merit on lactation response to long-term administration of recombinant bST. Cow index ranged from -70 to 456 (mean = 183) and -494 to -88 (mean = -288) kg milk for high and low genetic groups, respectively. Cows were blocked by calving date and randomly assigned to treatment within genetic group. Treatments were 0, 10.3, 20.6, and 30.9 mg somatotropin injected daily from wk 14 through 44 postpartum. Cows were fed one of two total mixed rations. Diet 1 (NE1 = 1.65 Mcal/kg, CP = 18%, and ADF = 22%) was fed from start of lactation to at least 4 wk after initiation of treatment. Cows were switched to diet 2 (NE1 = 1.56 Mcal/kg, CP = 16%, and ADF = 27%) when milk output fell below 25 kg/d. Forty-four week lactation yields were 9800 and 9447 kg milk; 364 and 354 kg fat; and 322 and 309 kg protein for high and low genetic groups, respectively. Milk, milk fat, or protein yield due to somatotropin did not differ between genetic groups. Increasing dosage of bST increased milk, 4% FCM, fat, and protein yields in a linear fashion. Percentages of fat and protein of milk were similar for all treatment groups. Body weight changes were not significantly different among treatments, but condition score changes decreased linearly with increasing dose of bST. Long-term treatment with recombinant bST had no apparent effect on incidence of health problems or reproduction.
authors.affiliation: Department of Dairy Science, University of Wisconsin, Madison 53706.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nytes
authors.forename: D K
authors.initials: DK
authors.lastname: Combs
authors.forename: G E
authors.initials: GE
authors.lastname: Shook
authors.forename: R D
authors.initials: RD
authors.lastname: Shaver
authors.forename: R M
authors.initials: RM
authors.lastname: Cleale
mesh_terms: D000818:Animals; D001835:Body Weight; D001947:Breeding; D002417:Cattle / Q000235:genetics / Q000502:physiology*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007774:Lactation / Q000187:drug effects* / Q000235:genetics; D016018:Least-Squares Analysis; D008892:Milk / Q000032:analysis; D011897:Random Allocation; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone