Serum vitamin D metabolites in cadmium-exposed persons with renal damage.
Serum concentrations of 25-hydroxyvitamin D [25(OH)D], 24,25-dihydroxyvitamin D [24,25(OH)2D], and 1 alpha,25-dihydroxyvitamin D [1 alpha,25(OH)2D] were measured in ten cadmium (Cd)-exposed subjects and five non exposed subjects. The Cd-exposed subjects were divided into two groups according to serum 1 alpha,25(OH)2D levels. No significant differences for 25(OH)D were found between the Cd-exposed group with low or normal serum 1 alpha,25(OH)2D and the non exposed group. The concentrations of 24,25(OH)2D were the lowest in the Cd-exposed group with low serum 1 alpha,25(OH)2D, highest in the non exposed group, and significantly lower in the Cd-exposed group with normal serum 1 alpha,25(OH)2D than in the non exposed group. Renal function was much worse in the Cd-exposed group with low serum 1 alpha,25(OH)2D than in the group with normal serum 1 alpha,25(OH)2D. These findings indicate that Cd initially disturbs hydroxylation from 25(OH)D to 24,25(OH)2D and then disturbs hydroxylation from 25(OH)D to 1 alpha,25(OH)2D. The decrease of serum 24,25(OH)2D and 1 alpha,25(OH)2D in Cd-exposed subjects is not due to a decrease of the serum 25(OH)D level.
Nogawa
K
K
Department of Hygiene, School of Medicine, Chiba University, Japan.
Tsuritani
I
I
Kido
T
T
Honda
R
R
Ishizaki
M
M
Yamada
Y
Y
D015650:24,25-Dihydroxyvitamin D 3 / Q000097:blood; D000328:Adult; D000368:Aged; D002104:Cadmium / Q000009:adverse effects*; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D004100:Dihydroxycholecalciferols; D002104:Cadmium; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol