title: Fluoxetine and the bleeding time.
abstract: Fluoxetine (Prozac) is a nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitor commonly prescribed for the treatment of depression. Fluoxetine also blocks 5-hydroxytryptamine reuptake in platelets and could potentially lead to clinically significant platelet dysfunction. We describe a patient who developed petechiae and prolongation of the bleeding time while receiving fluoxetine therapy.
authors.affiliation: Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: J E
authors.initials: JE
authors.lastname: Humphries
authors.forename: M S
authors.initials: MS
authors.lastname: Wheby
authors.forename: S R
authors.initials: SR
authors.lastname: VandenBerg
mesh_terms: D000328:Adult; D001760:Bleeding Time; D001792:Blood Platelets / Q000187:drug effects; D003863:Depression / Q000097:blood / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D011693:Purpura / Q000097:blood / Q000139:chemically induced*
chemical_list: D005473:Fluoxetine