Effect of L-carnitine and stimulated lipolysis on muscle substrates in the exercising rat.
To test the effect of L-carnitine on glycogen sparing when fat oxidation is increased, 100 mg/kg/d were given to rats orally for 3 days, resulting in 1.8-fold higher muscle carnitine levels. Even when FFA were raised by heparin-stimulated lipolysis, the rate of glycogen degradation was not reduced during exercise.
Décombaz
J E
JE
Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
Reffet
B
B
Bloemhard
Y
Y
D000818:Animals; D002331:Carnitine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005526:Food, Formulated; D006003:Glycogen / Q000378:metabolism; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D006003:Glycogen; D002331:Carnitine