title: [Effect of antimicrobial surface-active agents on the immune response to thymus-dependent antigen in mice].
abstract: The study showed that miramystin, a cationi surfactant, was an immunostimulant inducing an increase in humoral and cellular immunity in response to sheep red blood cells. The observed dose-dependent stimulating effect of miramystin on antibody production and development of DTH recommends its use as an immunologic adjuvant in the laboratory practice. It also indicated to the prospects in investigation of immunologic adjuvant properties of other preparations belonging to surface-active substances.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Krivoshein
authors.forename: V A
authors.initials: VA
authors.lastname: Shatrov
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects* / Q000276:immunology; D015478:Antigens, Heterophile / Q000276:immunology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology*; D007114:Immunization; D008297:Male; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D013501:Surface-Active Agents; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D015478:Antigens, Heterophile; D001548:Benzalkonium Compounds; D013501:Surface-Active Agents; C058048:miramistin
vernacular_title: Vliianie antimikrobnykh poverkhnostno-aktivnykh veshchestv na immunnyĭ otvet k timuszavisimomu antigenu u mysheĭ.