title: [Epidemiology of multiple primary cancer].
abstract: A definition of MPC by IARC and SEER and new methods for determining independent clonality of each MPC were introduced. A trend in frequency of multiple primary cancer (MPC) has been increasing in the National Cancer Center Hospital during 1962-1989. Frequent sites to cause MPC were esophagus (8.4%), larynx (8.2%), bladder (7.9%), colon (7.0%), oro-pharynx (5.5%), and an overall incidence was 2,082/54,888 (3.8%). The association of MPC showed a downstream relationship along the alimentary canal. A common exposure to carcinogenic stimuli in the digestive system was suggested. Smoking tobacco was a risk of frequent oro-pharynx, larynx and lung MPC by a case-control study. Effects of chemotherapy, irradiation and other treatments to cause MPC were introduced. A risk of hormone treatment and immunosuppressive drugs after tissue transplantation was discussed.
authors.affiliation: Epidemiology Division, National Cancer Center Research Institute.
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D007938:Leukemia / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D010610:Pharyngeal Neoplasms / Q000453:epidemiology