title: Ocular melanoma: total dose and dose rate effects with Co-60 plaque therapy.
abstract: From 1968 to 1987, 123 consecutive patients with nonmetastatic choroidal melanoma were treated with cobalt-60 plaques. One hundred sixteen patients were followed up for a mean of 3.8 years. Twenty patients had local failure, and 14 patients had distant failure. Complications included 32 cataracts, and seven enucleations were required. Local recurrence did not correlate with tumor height, tumor volume, dose, or dose rate. Increased volume (P = .004) and height (P = .01) correlated with increased rates of distant metastases. Dose adjusted for volume did not correlate with the rate of metastases.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY.
authors.forename: J J
authors.initials: JJ
authors.lastname: Beitler
authors.forename: B
authors.initials: B
authors.lastname: McCormick
authors.forename: R M
authors.initials: RM
authors.lastname: Ellsworth
authors.forename: D H
authors.initials: DH
authors.lastname: Abramson
authors.forename: L L
authors.initials: LL
authors.lastname: Anderson
authors.forename: C
authors.initials: C
authors.lastname: Loffredo
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects; D002386:Cataract / Q000209:etiology; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D009364:Neoplasm Recurrence, Local; D011879:Radiotherapy Dosage; D012189:Retrospective Studies
chemical_list: D003037:Cobalt Radioisotopes