title: Cerebral oxygen utilization analyzed by the use of oxygen-17 and its nuclear magnetic resonance.
abstract: In order to assess the usefulness of oxygen-17, a stable isotope of oxygen, oxygen-17, was administered to rats for studying cerebral oxygen utilization, and the produced metabolic water was detected by 17O-NMR spectroscopy in vitro and an 1H-NMR imaging system in vivo. In the vitro study, the increment in signal amplitude of oxygen-17 was observed in the brain extracted from rats that inhaled oxygen-17 gas. The in vivo study demonstrated that there were changes in the 1H-NMR image intensity of brain of rats that inhaled oxygen-17 gas. These facts indicate that oxygen-17 can serve as a tracer in the study of cerebral oxygen utilization.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Ishimori
authors.forename: I
authors.initials: I
authors.lastname: Morishima
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: B
authors.initials: B
authors.lastname: Fritz-Zieroth
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010103:Oxygen Isotopes; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010103:Oxygen Isotopes; D010100:Oxygen