title: Primary leptomeningeal gliomatosis with predominant involvement of the spinal cord.
abstract: The authors report on a 43-year-old male with apparent myelomeningeal encephalitis. The most important clinical symptoms included severe lymphocytosis of the CSF, cranial nerve palsies, obstructive hydrocephalus, progressive coma, and presence of an intramedullary mass causing paraplegia. Neither CSF analysis, nor the intraoperative findings gave evidence of a neoplastic process. Regarding the paraclinical data we supposed a CNS inflammatory process, but autopsy revealed the diagnosis of an intraspinal, leptomeningeal gliomatosis.
authors.affiliation: Institute of Neuropathology, Klinikum Rudolf Virchow, Freie Universität, Berlin.
authors.forename: N
authors.initials: N
authors.lastname: Heye
authors.forename: J R
authors.initials: JR
authors.lastname: Iglesias
authors.forename: K
authors.initials: K
authors.lastname: Tönsen
authors.forename: G
authors.initials: G
authors.lastname: Graef
authors.forename: K
authors.initials: K
authors.lastname: Maier-Hauff
mesh_terms: D000328:Adult; D001932:Brain Neoplasms; D003937:Diagnosis, Differential; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D006801:Humans; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000209:etiology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary