Desmoplastic cerebral astrocytoma of infancy. Light microscopy, immunocytochemistry, and ultrastructure.
The first detailed ultrastructural study of a superficial desmoplastic cerebral astrocytoma of infancy is reported. This is a neoplasm which mimics a mesenchymal tumor, originally described in 1984 under the name of "superficial cerebral astrocytoma attached to dura." This tumor, which is believed to have a good prognosis, was resected from the frontoparietal region of a 6.5-month-old girl, in whom it had presented as a large densely enhancing vascular and cystic mass. The ultrastructure of the tumor appeared to be distinctive, characterized by the absence of neuronal elements, and the presence of large amounts of redundant and sometimes extensively duplicated basal laminal material and collagen between nonpleomorphic and nonlipidized astrocytes, corresponding to the reticulin fibers seen by light microscopic analysis between the S-100 protein and glial fibrillary acidic protein (GFAP)-positive cells. The features of the tumor, its differential diagnosis, and its relationship to other pediatric supratentorial tumors are discussed.
de Chadarévian
J P
JP
Department of Pediatric Anatomical Pathology, St. Christopher's Hospital for Children, Philadelphia, PA 19133.
Pattisapu
J V
JV
Faerber
E N
EN
D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008854:Microscopy, Electron