[Early and late effects of the cytogenetic action of doxorubicin].
Cytogenetic disorders in hemopoietic cells of the bone marrow were studied on mice CBA at early and late periods after exposure to MIDs of doxorubicin, an anthracycline antibiotic. It was shown that at the early period doxorubicin induced aberrations, mainly of the chromatid type, in the hemopoietic cells of the bone marrow. Instability of the genetic apparatus of the hemopoietic cells observed for 3 months of the experiment was likely to be the immediate cause of the disorders in hemopoiesis at the late periods after exposure to doxorubicin.
Klimova
M Iu
MIu
Novitskiĭ
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations / Q000235:genetics*; D004317:Doxorubicin / Q000009:adverse effects*; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests / Q000379:methods; D009154:Mutation; D013997:Time Factors
D004317:Doxorubicin
Rannie i otdelannye éffekty tsitogeneticheskogo deĭstviia doksorubitsina.