Pharmacokinetics of amikacin during continuous veno-venous hemofiltration.
We studied the pharmacokinetics of amikacin in a patient with acute oliguric renal failure during continuous veno-venous hemofiltration (CVVH). The volume of distribution, terminal disposition rate constant and elimination half-life for amikacin were 27.9 L, 0.023.h-1 and 29.7 h, respectively. Total body clearance for amikacin was 10.54 ml/min and CVVH clearance was 10.11 ml/min. Sieving coefficient for amikacin was 0.93 +/- 0.16. Our data show that during CVVH at a filtration rate of 10 ml/min, the clearance of amikacin is similar to that reported in patients with renal failure who are not being treated with CVVH.
Armendariz
E
E
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA.
Chelluri
L
L
Ptachcinski
R
R
D058186:Acute Kidney Injury / Q000378:metabolism / Q000628:therapy; D000583:Amikacin / Q000493:pharmacokinetics*; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008875:Middle Aged
D000583:Amikacin