Pathophysiology of the periparturient egg rise in sheep: the role of prolactin.
The involvement of prolactin in the periparturient rise in the faecal nematode egg count in sheep was investigated. Ostertagia circumcincta larvae (5000 third stage larvae three times weekly) were administered to adult immune ewes from three weeks before parturition to three weeks afterwards. Ten ewes were injected twice daily with 2-bromo-alpha-ergocryptine (bromocriptine), an antagonist of prolactin secretion, for two weeks starting two days after lambing while 10 ewes remained untreated. Bromocriptine treatment was initiated approximately two weeks pre partum in three other ewes. Plasma pepsinogen concentrations rose significantly by one week after the start of O circumcincta larval challenge in all the ewes but faecal egg counts remained negative until approximately one week post partum. Plasma prolactin concentration was reduced to a very low level in all bromocriptine treated ewes but this did not alter the dynamics of the periparturient rise in faecal egg counts. Neither cell-mediated nor humoral immunity of the ewes, as assessed by their sensitivity to BCG inoculation and by antibody titre raised against horse red blood cells, respectively, were impaired during the rise in faecal egg count, nor were these parameters altered by manipulation of plasma prolactin concentration. Lamb growth rate was not retarded by low plasma prolactin concentration in the bromocriptine treated ewes. These results are not consistent with the generally held hypothesis that elevated plasma prolactin concentration is directly associated with the periparturient rise.
Jeffcoate
I A
IA
Department of Veterinary Physiology, University of Glasgow Veterinary School.
Fishwick
G
G
Bairden
K
K
Armour
J
J
Holmes
P H
PH
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D001724:Birth Weight; D001835:Body Weight; D001971:Bromocriptine / Q000494:pharmacology; D005243:Feces / Q000469:parasitology; D005260:Female; D006386:Hemagglutination Tests; D007111:Immunity, Cellular; D007744:Obstetric Labor Complications / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D010028:Ostertagia / Q000254:growth & development* / Q000276:immunology; D010029:Ostertagiasis / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D000909:Antibodies, Helminth; D010435:Pepsinogens; D001971:Bromocriptine; D011388:Prolactin