Lamins A and C are not expressed at early stages of human lymphocyte differentiation.
Lamins are major proteins of the nuclear envelope that are members of the intermediate filament protein family. In vertebrates, nuclei from differentiated tissues usually contain both lamins of the A and B subtypes, while embryonic tissues contain the B-type lamin only. We have examined the composition of the nuclear lamina in human B and T lymphocytes representative of distinct stages of lymphoid differentiation. We show here that, in both cell lineages, while lamin B is constitutively expressed at all stages of differentiation, A-type lamin expression is restricted to later developmental stages.
Guilly
M N
MN
Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France.
Kolb
J P
JP
Gosti
F
F
Godeau
F
F
Courvalin
J C
JC
D000818:Animals; D001402:B-Lymphocytes / Q000032:analysis* / Q000166:cytology; D002454:Cell Differentiation; D002460:Cell Line; D002467:Cell Nucleus / Q000032:analysis; D006801:Humans; D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D013601:T-Lymphocytes / Q000032:analysis* / Q000166:cytology; D014407:Tumor Cells, Cultured
D034921:Lamin Type B; D034882:Lamins; D009687:Nuclear Proteins; D012333:RNA, Messenger