The effects of propofol and thiopentone on forearm circulation.
Some effects of propofol and thiopentone induction on the peripheral circulation of healthy patients are examined using mercury strain gauge venous occlusion plethysmography of the forearm. Results indicate that both drugs produce a statistically significant decrease in mean arterial blood pressure and forearm blood flow. Forearm vascular resistance remains unchanged after either drug. These data suggest that bolus dose induction of anaesthesia with propofol does not cause arterial vasodilatation of the limb and that a cause for the reduction in mean arterial pressure must be sought elsewhere.
McKeating
K
K
Department of Anaesthetics, Queen's University of Belfast.
Howe
J P
JP
McArdle
L
L
D000328:Adult; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D013874:Thiopental; D015742:Propofol