[Pregnancy following liver transplantation and during immunosuppression with cyclosporine].
Orthotopic liver transplantation had been performed in 1983 in a now 40-year-old woman in the terminal stage of posthepatitis liver cirrhosis with recurrent oesophageal bleedings and precoma from complete liver-cell failure. She became pregnant in 1988 while under immunosuppression with cyclosporin (2.1-2.7 mg/kg body-weight) and prednisolone (5 or 7.5 mg daily in rotation). Pregnancy proceeded without complication and there were no side effects from cyclosporin. After premature membrane rupture in the 39th week of pregnancy uterine inertia developed during oxytocin stimulation of contractions, and caesarean section was performed. The female infant was normally developed without any malformations. Liver, kidney and adrenal functions were normal, as was haemopoiesis. But possible late sequelae of cyclosporin treatment in the child cannot as yet be assessed because of the short follow-up.
Günter
H H
HH
Zentrum Frauenheilkunde, Medizinischen Hochschule, Hannover.
Mauz
S
S
Ringe
B
B
Niesert
S
S
D000014:Abnormalities, Drug-Induced; D000328:Adult; D002585:Cesarean Section; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008103:Liver Cirrhosis / Q000601:surgery; D016031:Liver Transplantation; D011247:Pregnancy / Q000187:drug effects*; D011256:Pregnancy Outcome
D003524:Cyclosporins
Schwangerschaft nach Lebertransplantation und unter Immunsuppression mit Ciclosporin.