Serum protein binding of antiepileptic drugs in Sri Lankans.
The percentage protein binding of antiepileptic drugs was investigated in epileptic patients (n = 90) undergoing treatment with phenobarbitone, phenytoin and carbamazepine either as a single drug therapy or in different combinations. When administered individually, the percentage (mean +/- SEM) protein binding of phenobarbitone, phenytoin and carbamazepine were 50.84 +/- 7.03, 87.23 +/- 2.98 and 76.80 +/- 6.30 respectively. Combination of phenobarbitone and phenytoin resulted in percentage (mean +/- SEM) protein binding of 51.94 +/- 6.09 for phenobarbitone and 83.54 +/- 7.01 for phenytoin, while the combination of phenobarbitone and carbamazepine resulted in percentage (mean +/- SEM) protein binding of 49.60 +/- 2.59 for phenobarbitone and 79.10 +/- 3.31 for carbamazepine. When phenytoin was given with carbamazepine percentage (mean +/- SEM) protein binding was 87.22 +/- 4.48 for phenytoin and 72.50 +/- 5.92 for carbamazepine.
Karunanayake
E H
EH
Faculty of Medicine, University of Colombo, Sri Lanka.
Joice
P D
PD
Peiris
J B
JB
Meijer
J W
JW
Meinardi
H
H
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000378:metabolism*; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism*; D002220:Carbamazepine / Q000378:metabolism; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000378:metabolism; D010672:Phenytoin / Q000378:metabolism; D011485:Protein Binding; D013188:Sri Lanka
D000927:Anticonvulsants; D001798:Blood Proteins; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital