title: In vitro activity of protoanemonin, an antifungal agent.
abstract: Protoanemonin, the lactone of gamma-hydroxy-vinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 micrograms/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg.
authors.affiliation: Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Martín
authors.forename: L
authors.initials: L
authors.lastname: San Román
authors.forename: A
authors.initials: A
authors.lastname: Domínguez
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010944:Plants / Q000032:analysis*
chemical_list: D000935:Antifungal Agents; D005663:Furans; C037354:protoanemonin