title: [Experimental studies of the possibilities of radioimmunodetection of cancer of the large intestine by subcutaneous administration of iodinated antibodies to intestinal antigen beta1-MA].
abstract: 131I- and 125I-labeled rabbit antibodies (AB) to the specific human intestinal beta 1MA were administered sc and iv to nude mice xenografts of human colon carcinoma. A study was made of the pharmacokinetics of labeled AB in the recipients' organs and tissues, measuring the radioactivity of tissue specimens on days 2, 3, 4 and 7 after injection with a gamma-counter, calculating specific radioactivity and accumulation indices. Tumors were visualized with a gamma-camera and a scanner. Proceeding from the comparison of the results of sc and iv administration of iodinated AB, a conclusion has been made of the applicability of sc injections of the agent for immunoscintigraphy.
authors.forename: S K
authors.initials: SK
authors.lastname: Aleksander
authors.forename: L M
authors.initials: LM
authors.lastname: Fidler
authors.forename: V V
authors.initials: VV
authors.lastname: Mit'kov
authors.forename: K K
authors.initials: KK
authors.lastname: Pugachev
authors.forename: G I
authors.initials: GI
authors.lastname: Avdeev
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007414:Intestinal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D007420:Intestine, Large; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011877:Radionuclide Imaging; D012004:Rectal Neoplasms / Q000276:immunology
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
vernacular_title: Eksperimental'noe izuchenie vozmozhnosti radioimmunodetektsii rakatolstoĭ kishki pri podkozhnoĭ vvedenii ĭodirovannykh antitel k kishechnomu antigenu beta1 MA.