title: The development of the acinar heterotopic pattern of phosphoenolpyruvate carboxykinase activity in the newborn rat.
abstract: The postnatal appearance of phosphoenolpyruvate carboxykinase activity (PEPCK) and acinar heterotopy was investigated in newborn rats aged 2 h, 12 h, 24 h and 3 days, as well as in juvenile rats aged 25 days. The livers showed an almost homogeneous distribution of activity along the sinusoidal length at the beginning of extrauterine life where energy needs are greatest. Compared to rats aged 2 h, the PEPCK activity was higher in the livers from rats aged 12 h. The increase in activity was most pronounced in the intermediary zone. After 24 h of extrauterine life the activity decreased again creating a homogeneous acinar activity pattern. By day 3 activity had increased in the periportal zone, while decreasing in the perivenous zone, resulting in a periportal to perivenous gradient. By day 25 total activity had reached highest values both in males and females, due to a relatively high perivenous activity. The more prominent acinar gradient corresponded approximately to the one seen in adult animals.
authors.affiliation: Anatomisches Institut der Universität Basel, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Wimmer
authors.forename: C
authors.initials: C
authors.lastname: Luttringer
authors.forename: M
authors.initials: M
authors.lastname: Colombi
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D010729:Phosphoenolpyruvate Carboxykinase (GTP)