title: Influence of nootropic drugs on apomorphine-induced stereotyped behaviour in rats.
abstract: In an attempt to identify the functional role of cerebral dopaminergic processes for the action of nootropic drugs the influence of piracetam, meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate on apomorphine-induced stereotyped behaviour was studied. Meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate enhanced significantly the apomorphine-elicited stereotypy in rats without triggering the behaviour itself. Piracetam (300, 500 or 1000 mg/kg ip.) was ineffective in this test. These results support the assumption that the functional activation of cerebral aminergic processes plays a possible role in the mode of action of some typical representatives of nootropic drugs.
authors.affiliation: Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, GDR.
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D011619:Psychotropic Drugs; D001058:Apomorphine