title: [Familial nonneoplastic inappropriate thyrotropin secretion].
abstract: A follicular thyroid carcinoma was suspected in a 62-year-old woman after the fifth goitre excision for non-neoplastic inappropriate thyrotropin secretion. Small-follicular adenoma could not be excluded histologically. After an attempt at thyrotropin suppression with L-thyroxine, triiodothyronine, D-thyroxine with L-thyroxine, and bromocriptine had failed, lasting if partial decrease in the maximally elevated TSH levels was achieved with triiodothyroacetic acid (TRIAC). One of the patient's three daughters also has non-neoplastic inappropriate thyrotropin secretion and has had two goitre excisions. It is most likely a familial form of inappropriate TSH secretion.
authors.affiliation: Medizinische Klinik und Poliklinik, Universität des Saarlandes, Homburg/Saar.
authors.forename: H J
authors.initials: HJ
authors.lastname: Langer
authors.forename: E
authors.initials: E
authors.lastname: Leicht
authors.forename: B
authors.initials: B
authors.lastname: Koch
authors.forename: B
authors.initials: B
authors.lastname: Weinheimer
authors.forename: R
authors.initials: R
authors.lastname: Berberich
authors.forename: P
authors.initials: P
authors.lastname: Strohfeldt
authors.forename: K F
authors.initials: KF
authors.lastname: Weinges
mesh_terms: D002277:Carcinoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006042:Goiter / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012086:Reoperation; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D013964:Thyroid Neoplasms / Q000175:diagnosis; D013965:Thyroidectomy; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000008:administration & dosage; D014284:Triiodothyronine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D014284:Triiodothyronine; C010642:3,3',5-triiodothyroacetic acid; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Familiäre, nicht-neoplastische inadäquate Thyreotropin-Inkretion.