[Disease-specific and non-specific seasonal parameter changes in hayfever patients].
10 patients have been treated by subcutaneous injections of placebo three times weekly for 4 weeks within a phase-I trial of BCH-069. Immunological, hematological and biochemical parameters were observed at different times: preseasonal, seasonal and postseasonal. --Some new observations are reported, which are induced by the seasonal inflammation. For example there was a strong increase of C-reactive protein and also an increase in the triglyceride level. --The parameters could be useful for trials of new antiallergic drugs in hay fever in the future.
Simon
H U
HU
Institut für Klinische Immunologie, Friedrich-Schiller-Universität Jena.
Metzner
G
G
Keil
E
E
Piesch
C
C
Schlenvoigt
G
G
Storz
H
H
Jäger
L
L
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001798:Blood Proteins / Q000032:analysis; D001985:Bronchial Provocation Tests; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007167:Immunotherapy; D008077:Lipoproteins, LDL / Q000032:analysis; D009842:Oligopeptides / Q000627:therapeutic use; D010446:Peptide Fragments / Q000627:therapeutic use; D010991:Plethysmography; D011058:Pollen / Q000032:analysis / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology* / Q000628:therapy; D012621:Seasons; D014280:Triglycerides / Q000097:blood
D000276:Adjuvants, Immunologic; C064311:BCH 069; D001798:Blood Proteins; D007136:Immunoglobulins; D008077:Lipoproteins, LDL; D009842:Oligopeptides; D010446:Peptide Fragments; D014280:Triglycerides; D002097:C-Reactive Protein
Krankheitsspezifische und -unspezifische saisonale Parameterveränderungen bei Pollinosepatienten.