Oxygen-induced proliferative retinopathy in the newborn rat.
The neonatal rat, which has an immature retinal vasculature at the time of birth, is a potential animal model for retinopathy of prematurity since it has an established spindle cell retinal vasoformation pattern similar to that seen in the human. To determine if proliferative oxygen-induced retinopathy can be produced in the rat, 40 newborn rat pups were exposed from birth either to air for 25 days or to an 80% oxygen environment for 10 days, followed by 15 days in air. Extraretinal neovascularization was observed in 80% (16/20) of the rat pups exposed to hyperoxia (p less than 0.001) with a bilaterality of 87.5% (14/16). Mild to moderate vitreous hemorrhage was seen in only three eyes. Mesenchymal shunt or ridge formation was not demonstrated, nor was retinal detachment.
Ventresca
M R
MR
Department of Ophthalmology, Ivey Institute of Ophthalmology, London, Ont.
Gonder
J R
JR
Tanswell
A K
AK
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012171:Retinal Vessels / Q000473:pathology; D012178:Retinopathy of Prematurity / Q000209:etiology / Q000473:pathology*
D010100:Oxygen