[The new concept of osteoporosis. Early diagnosis, prevention and therapy are possible today].
A paradigma of osteoporosis pathology is discussed, at the center of which is the hormone-related disturbance of the osteoblast/osteoclast functional unit. A liberal replacement of estrogen-gestagen in post-menopausal women is advocated. Early diagnosis with the aid of quantitative computed tomography makes it possible to establish the indication for timely hormonal treatment in the future, which can result in a measureable increase in bone mass. Late therapy, that is, treatment initiated after the occurrence of fractures, has proven largely ineffective.
Hesch
R D
RD
Abteilung für klinische Endokrinologie, Departement Innere Medizin der Medizinischen Hochschule Hannover.
Harms
H
H
Rittinghaus
E F
EF
Brabant
G
G
D002116:Calcitonin / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D005598:Fractures, Spontaneous / Q000517:prevention & control; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000187:drug effects*; D010024:Osteoporosis / Q000628:therapy*; D015663:Osteoporosis, Postmenopausal / Q000628:therapy*; D010281:Parathyroid Hormone / Q000008:administration & dosage*
D010281:Parathyroid Hormone; D002116:Calcitonin; D005459:Fluorides
Das neue Konzept der Osteoporose. Frühdiagnose, Prävention und Frühtherapie sind heute möglich.