Liver plasma membrane proteins in chronic ethanol intoxication.
Plasma membrane proteins were isolated from control and ethanol-treated rat livers by the use of two-dimensional gel electrophoresis (IEF-SDS-PAGE). Two groups of proteins differing in their response to ethanol were analysed and termed as ethanol-sensitive proteins (ESP) and ethanol insensitive proteins (EISP). This study indicates a loss of many membrane-associated proteins and strongly suggests a role for these proteins in the mechanism of plasma membrane disruption by ethanol.
Babu
P P
PP
School of Life Sciences, University of Hyderabad, India.
Vemuri
M C
MC
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects* / Q000302:isolation & purification; D051381:Rats; D011919:Rats, Inbred Strains
D008565:Membrane Proteins