title: Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome.
abstract: A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to +/- 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Mo.
authors.forename: E J
authors.initials: EJ
authors.lastname: Devor
authors.forename: D K
authors.initials: DK
authors.lastname: Grandy
authors.forename: O
authors.initials: O
authors.lastname: Civelli
authors.forename: M
authors.initials: M
authors.lastname: Litt
authors.forename: A K
authors.initials: AK
authors.lastname: Burgess
authors.forename: K E
authors.initials: KE
authors.lastname: Isenberg
authors.forename: B J
authors.initials: BJ
authors.lastname: van de Wetering
authors.forename: B
authors.initials: B
authors.lastname: Oostra
mesh_terms: D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D011954:Receptors, Dopamine / Q000235:genetics*; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: D015342:DNA Probes; D011954:Receptors, Dopamine