[The effect of ethosuximide on epileptic after-discharges induced by thalamic stimulation in young laboratory rats].
An influence of ethosuximide on thalamically induced epileptic afterdischarges was studied in 47 rats aged 12 and 18 days. An afterdischarge formed by spike-and-wave rhythm was induced only in 18-day-old rats. It exhibited a tendency to progressive prolongation with repeated stimulations (with 15 min intervals). Ethosuximide in a dose of 125 mg/kg i.p. immediately after the first afterdischarge did not change the duration of subsequent afterdischarges. The second type of epileptic afterdischarge formed by spikes and/or serrated waves could be induced in both age groups studied. Ethosuximide even worsened the tendency to progression of epileptic afterdischarges in 12- as well as 18-day-old animals. Ethosuximide did not exhibit an anticonvulsant action against the spike-and-wave afterdischarge in 18-day-old rats. On the contrary, it aggravated the course of progressive changes with repeated stimulations in both age groups.
Maresová
D
D
Fyziologický ústav fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Mares
P
P
Langmeier
M
M
Trojan
S
S
D000375:Aging / Q000502:physiology; D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000503:physiopathology*; D005013:Ethosuximide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000503:physiopathology*
D005013:Ethosuximide
Ucinek ethosuximidu na epileptické následné výboje vyvolané drázdĕním talamu u mládat laboratorního potkana.