Neuroparalytic keratitis and capsaicin.
Subcutaneous injection of 50 mg/kg capsaicin to newborn rats resulted in a marked decrease of heat pain sensitivity and neurogenic inflammation. There was, however, no significant difference between capsaicin-pretreated and control rats in the severity of neuroparalytic keratitis after surgical deafferentation of the eye. Retrobulbar injection of 100 microliters of 0.5% capsaicin produced keratitis-like corneal changes. These changes were not prevented by previous pretreatment with a total subcutaneous dose of 200 mg/kg capsaicin. The findings indicate that corneal changes after deafferentation are not due to excessive release of substance P and other neuropeptides from the degenerating afferent fibres.
Knyazev
G G
GG
Institute of Physiology, Siberian Branch of the Academy of Medical Sciences of the USSR, Novosibirsk.
Knyazeva
G B
GB
Nikiforov
A F
AF
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D003714:Denervation; D005070:Evans Blue; D007634:Keratitis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009479:Neuropeptides / Q000502:physiology*; D009882:Ophthalmic Nerve / Q000502:physiology* / Q000601:surgery; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D005070:Evans Blue; D002211:Capsaicin