title: Juvenile ossifying fibroma. Report of four cases.
abstract: The present investigation concerns 4 patients with juvenile ossifying fibroma (JOF) whose data are analyzed together with 30 cases from the literature. The tumour mainly occurs in juveniles, 79% of the patients being 15 years or younger. Radiologically as well as at surgery, the lesion is demarcated from its surroundings. Histologically, JOF is unique in showing a loose-fibroblastic stroma that contains garland-like strands of osteoid with entrapped osteoblasts, the latter feature not being observed in other fibro-osseous lesions. JOF responds very well to conservative treatment that provided permanent cure in all cases with adequate follow-up data.
authors.affiliation: Institute of Pathology, University of Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Slootweg
authors.forename: H
authors.initials: H
authors.lastname: Müller
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008441:Maxillary Neoplasms / Q000473:pathology*; D010016:Osteoma / Q000473:pathology*