Effect of cyclosporin A on aldosterone production by dispersed rabbit adreno-capsular cells.
The effect of cyclosporin A on aldosterone production by dispersed adreno-capsular cells from rabbit was examined. Cyclosporin A significantly stimulated aldosterone production at concentrations of 10(-7) M and 10(-6) M. The maximum stimulation of aldosterone production by cyclosporin A (at 10(-6) M) was comparable to that by angiotensin II at 10(-8) M). This stimulating effect of cyclosporin A on aldosterone production was not accompanied by an increase in cyclic AMP production, and was not inhibited by a calcium-channel blocker, nicardipine. These results suggest that the aldosterone-stimulating action of cyclosporin A at these concentrations is not mediated by a known second messenger system such as channel-linked Ca2+ inflow or cyclic AMP.
Morishita
R
R
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Higaki
J
J
Mikami
H
H
Ogihara
T
T
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D002478:Cells, Cultured; D003524:Cyclosporins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009529:Nicardipine / Q000494:pharmacology; D011817:Rabbits
D003524:Cyclosporins; D000450:Aldosterone; D009529:Nicardipine