title: Clinical course and pathologic features of conjunctival non-Hodgkin's lymphoma. A report of six cases.
abstract: Six patients with conjunctival non-Hodgkin's lymphoma (NHL) were evaluated. In all six cases the conjunctiva was the primary site of clinical presentation; four cases involved low-grade malignancy and two, intermediate-grade malignancy, according to the International Working Formulation. The disease developed within a short period of time to stage IV. The poor response to therapy revealed a worse prognosis than would be expected according to the histopathologic classification. Four of the six patients died of NHL, three of them within 15 months. Comparison of these 6 cases with a group of 15 patients with orbital NHL revealed a much better prognosis in the latter patients. In spite of the fact that 4 of the 15 orbital cases showed NHL of high-grade malignancy, only 2 of them died of the lymphoma. Therefore, conjunctival NHL requires a fast and adequate diagnostic and therapeutic approach.
authors.affiliation: Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
authors.forename: H A
authors.initials: HA
authors.lastname: Khalil
authors.forename: R J
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: P M
authors.initials: PM
authors.lastname: Kluin
authors.forename: H C
authors.initials: HC
authors.lastname: Kluin-Nelemans
authors.forename: D
authors.initials: D
authors.lastname: de Wolff-Rouendaal
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003230:Conjunctival Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology; D011379:Prognosis
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents