title: Effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human myometrium.
abstract: The effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human isthmic myometrium was examined. Methergin (10(-8)-10(-6) g/ml) enhanced plateau potential and contraction, however, the effects were not prominent. Plateau potential and contraction were also potentiated after pretreatment with 10(-7) g/ml phentolamine (alpha-blocker), however 10(-7) g/ml methergin further increased these effects. It is suggested that methergin might potentiate contractions by changing the pattern of action potentials and not by alpha-adrenoceptor.
authors.affiliation: Department of Obstetrics and Gynecology, Saga Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: T
authors.initials: T
authors.lastname: Kishikawa
authors.forename: H
authors.initials: H
authors.lastname: Sugimori
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008755:Methylergonovine / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D008755:Methylergonovine