title: Control of intraocular pressure after cataract extraction.
abstract: We carried out a prospective randomized study in 172 patients undergoing cataract extraction and lens implantation to compare the effects of pilocarpine gel, 1% acetylcholine chloride and 0.01% carbachol on early postoperative intraocular pressure (IOP), to determine the effect of sodium hyaluronate on IOP and to compare the effects of 0.01% carbachol (full-strength) and 0.005% carbachol (half-strength) on IOP, pupil size and brow ache. IOP was measured 3, 6, 9 and 24 hours after surgery, and in the full- and half-strength carbachol groups pupil size and subjective complaints of brow ache were recorded. The mean IOP 3 and 6 hours after surgery was significantly lower in all the treatment groups than in the control groups. At 9 and 24 hours it was significantly lower only in the carbachol groups. The use of sodium hyaluronate was not found to affect the postoperative IOP. There was no difference in postoperative IOP or miosis between the full- and half-strength carbachol groups, but fewer patients in the half-strength group than in the full-strength group reported brow ache at 9 and 24 hours. The results suggest that carbachol is the most effective agent currently available for the management of IOP after cataract extraction.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver.
authors.forename: R H
authors.initials: RH
authors.lastname: Hollands
authors.forename: S M
authors.initials: SM
authors.lastname: Drance
authors.forename: P H
authors.initials: PH
authors.lastname: House
authors.forename: M
authors.initials: M
authors.lastname: Schulzer
mesh_terms: D000109:Acetylcholine / Q000627:therapeutic use; D000704:Analysis of Variance; D002217:Carbachol / Q000008:administration & dosage / Q000627:therapeutic use; D002387:Cataract Extraction; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007429:Intraocular Pressure / Q000187:drug effects*; D007910:Lenses, Intraocular; D010862:Pilocarpine / Q000627:therapeutic use; D011182:Postoperative Care; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects; D011897:Random Allocation
chemical_list: D010862:Pilocarpine; D002217:Carbachol; D006820:Hyaluronic Acid; D000109:Acetylcholine