[Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes].
Total content of phospholipids and their individual components were distinctly increased in microsomal, mitochondrial fractions and in inner mitochondrial membrane of rat hepatocytes under conditions of alloxan diabetes. The concentrations of these substances were decreased in outer mitochondrial membrane. Activation of lipid free-radical oxidation was found in all the membrane structures studied. In microsomal fraction of hepatocytes the rate of hydroxylation reaction was decreased, accompanied by a decrease in content of cytochromes b5 and P-450.
Karagezian
K G
KG
Ovsepian
L M
LM
Adonts
K G
KG
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006900:Hydroxylation; D007425:Intracellular Membranes / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D008563:Membrane Lipids; D010743:Phospholipids; D008315:Malondialdehyde; D003577:Cytochrome P-450 Enzyme System
Okislitel'nye protsessy i obmen fosfolipidov v membrannykh strukturakh gepatotsitov pri alloksanovom diabete.