Anti-inflammatory activity and sub-acute toxicity of artemetin.
The 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.
Sertié
J A
JA
Department of Pharmacology, Universidade de São Paulo, Brasil.
Basile
A C
AC
Panizza
S
S
Matida
A K
AK
Zelnik
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; C054132:artemetin