[In vitro synergism of two-drug combinations among cefamandole, flomoxef and imipenem against MRSA].
First of all, vancomycin (VCM) showed good antimicrobial activity against Staphylococcus aureus including methicillin-sensitive and -resistant strains. MIC90 of VCM was 1.56 micrograms/ml. Effects of different 2-drug combinations among cefamandole (CMD), flomoxef (FMOX) and imipenem (IPM), and activity of VCM alone were examined in vitro against 5 clinical isolates of methicillin-sensitive S. aureus (MSSA) and 22 isolates of methicillin-resistant S. aureus (MRSA). In a checkerboard study, synergism was observed against 4 strains of the 5 MSSA and all 22 strains of the MRSA with IPM and CMD, FMOX and IPM, and FMOX and CMD combinations. Mean MICs of these combinations were as low as one-fourth to one-tenth as those of individual drugs.
Inoue
M
M
Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine.
Sakurai
N
N
Matsui
H
H
Tsunoda
M
M
Okubo
T
T
D015311:Cefmetazole / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D015378:Imipenem / Q000494:pharmacology*; D008712:Methicillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
D002511:Cephalosporins; D004338:Drug Combinations; D015311:Cefmetazole; D015378:Imipenem; D008712:Methicillin; C045693:flomoxef