Calcium channel blockers: effect on morphine-induced hypermotility.
Acute morphine treatment has been shown to cause a uniform calcium depletion in various brain regions and to evoke hypermotility in mice. On the other hand, it has been reported previously that calcium channel blockers reduce the behavioral stimulation induced by different methods in mice, and it is known that these drugs increase the morphine analgesia and reduce the abstinence syndrome. The effect of calcium channel blockers, nifedipine and diltiazem, on the morphine- and amphetamine-induced hypermotility were evaluated. Mice activity was measured with photocell motility meters. The results show that neither nifedipine nor diltiazem decrease significantly the motility in control and amphetamine-treated mice; however, when they were administered to morphine-treated mice the hypermotility was significantly reduced. The mechanism responsible for this interference is still unknown.
Martin
M I
MI
Instituto de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Lizasoain
I
I
Leza
J C
JC
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology
D002121:Calcium Channel Blockers; D009020:Morphine; D004110:Diltiazem; D009543:Nifedipine; D003913:Dextroamphetamine