[A study of clinical safety of lithium levels in the serum and erythrocytes].
A correlative and regression analysis of the serum and erythrocyte lithium level (SLL and ELL) were investigated on 135 times in 31 patients with lithium therapy. It was found that the levels of both were positively-correlated with statistical significance (r = 0.8174). The levels of both and their ratio in relation to clinical manifestation were studied. It was showed that while ELL exceeded 1 mEq/L, SLL exceeded 1.2 mEq/L and the ratio between ELL and SLL exceeded 0.8: 1, symptoms of lithium intoxication occurred in 4 or 5 cases. It is suggested that lithium intoxication may possibly occur when SLL and ELL as well as their ratio reaches the above-mentioned criterion.
Wang
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D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D008094:Lithium