title: The pathology of Johne's disease in sheep.
abstract: The clinical, gross and histopathological findings in 50 sheep affected with Johne's disease are described. Clinically 90% were emaciated and 20% showed severe diarrhoea. On necropsy there was thickening of the walls of the intestines, particularly of the ileum, caecum and less frequently the jejunum, but in 36% of sheep the changes were only mild. Histologically there was a granulomatous enteritis, typhlitis and colitis, with the most severe changes in the terminal ileum. High numbers of acid-fast organisms were present in the terminal ileum in over 70% of sheep. Mycobacterium paratuberculosis was cultured from only 8% of the sheep examined.
authors.affiliation: New South Wales Agriculture and Fisheries, Agricultural Research and Veterinary Centre, Orange, New South Wales.
authors.forename: M J
authors.initials: MJ
authors.lastname: Carrigan
authors.forename: J T
authors.initials: JT
authors.lastname: Seaman
mesh_terms: D000818:Animals; D005260:Female; D007422:Intestines / Q000473:pathology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010283:Paratuberculosis / Q000473:pathology*; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*