title: General anesthesia does not alter the viscoelastic or transport properties of human respiratory mucus.
abstract: Observations that mucus transport rates (MTR) are depressed in anesthetized animals and humans have led to speculation that general anesthesia depresses ciliary activity or adversely alters the physical properties of the respiratory mucus (RM). We investigated the possibility that anesthesia changes the physical properties of RM in such a way as to depress ciliary transport. We collected 33 samples of RM from the endotracheal tubes (ETTs) of 25 people aged 1 to 79 years undergoing elective surgery who had no clinical evidence of lung disease. We measured the rigidity, viscoelasticity, spinnability, and the percentage of solid composition of these specimens as well as the transport of the collected RM across the mucus-depleted frog palate. These physical properties were not significantly different from RM collected from awake volunteers using the bronchoscopy brush collection technique. Differences in spinnability, transportability, and solid content of paired mucus samples from the inside and outside of the ETTs are suggestive of altered RM hydration, but this requires further study. The decrease in MTR during general anesthesia is probably due to mechanisms other than alterations in the physical properties of mucus.
authors.affiliation: University of Alberta, Department of Pediatrics (Pulmonary), Edmonton, Canada.
authors.forename: B K
authors.initials: BK
authors.lastname: Rubin
authors.forename: B
authors.initials: B
authors.lastname: Finegan
authors.forename: O
authors.initials: O
authors.lastname: Ramirez
authors.forename: M
authors.initials: M
authors.lastname: King
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D004548:Elasticity; D005260:Female; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects / Q000502:physiology*; D009093:Mucus / Q000187:drug effects / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D014783:Viscosity