title: Antibodies to interleukin 2 in sera of autoimmune-prone mice.
abstract: Autoimmune-prone mice spontaneously develop the disease characterized by autoantibodies to a wide variety of antigens. In the present study, we have demonstrated that IgG antibodies to interleukin 2 (IL-2) are to be found in serum of autoimmune mice in association with ageing. These antibodies can neutralize the biological activity of IL-2 and thus play an important role in the etiopathogenesis of autoimmune disease.
authors.affiliation: First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tabata
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Kaga
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Kasama
authors.forename: T
authors.initials: T
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: N
authors.initials: N
authors.lastname: Yamagata
authors.forename: F
authors.initials: F
authors.lastname: Sekine
authors.forename: I
authors.initials: I
authors.lastname: Ohno
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology*; D004198:Disease Susceptibility; D005260:Female; D006824:Hybridization, Genetic; D007074:Immunoglobulin G / Q000032:analysis; D007376:Interleukin-2 / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood / Q000502:physiology*; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007376:Interleukin-2; D012217:Rheumatoid Factor