title: [Different rates of theophylline clearance. A statistical study of a group of asthmatics].
abstract: In standard clinical practice the pharmacokinetic profile of theophylline is monitored by measuring blood levels of the drug. However a more accurate picture of the metabolic pattern over time can be obtained by monitoring theophylline clearance. This technique was applied to 40 lung disease patients most (55%) of them slow metabolisers as described in the literature. In the light of this findings, cautious dosing is advisable when no data are available or clearance (difficult to apply outside a strictly specialist environment).
authors.affiliation: Ospedale Pneumologico S Luigi Gonzaga, Orbassano, Torino.
authors.forename: R
authors.initials: R
authors.lastname: Gai
authors.forename: A
authors.initials: A
authors.lastname: Oliaro
authors.forename: F
authors.initials: F
authors.lastname: Galietti
authors.forename: G E
authors.initials: GE
authors.lastname: Giorgis
authors.forename: S
authors.initials: S
authors.lastname: Bruna
authors.forename: A
authors.initials: A
authors.lastname: Ardizzi
authors.forename: M
authors.initials: M
authors.lastname: Bianchi
authors.forename: W
authors.initials: W
authors.lastname: Bernardi
mesh_terms: D001249:Asthma / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011863:Radioimmunoassay; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D013806:Theophylline
vernacular_title: Studio delle diverse velocità di clearance della teofillina. Studio statistico su un gruppo di asmatici.