title: Prostaglandin E2 and F2 alpha levels in the duodenal and antral mucosa of non-ulcer dyspeptic and duodenal ulcer patients.
abstract: In the present study we evaluated the contents of endogenous prostaglandins type E2 and F2 alpha in the antral mucosa, and the type E2 in the duodenal mucosa in a group of thirty non-ulcer dyspeptics in comparison with a group of thirty duodenal ulcer patients. A significantly reduced concentration of duodenal and antral PGE2 was found in ulcer patients as compared with dyspeptic subjects. A significantly increased concentration of antral PGE2 was observed in cases with active superficial antral gastritis, either in dyspeptics or in duodenal ulcer patients, as compared with normal antrum cases. A significantly increased level of PGF2 alpha was found in active superficial gastritis of the dyspeptic group.
authors.affiliation: Dept. of Gastroenterology, S. Martino Hospital, Genoa, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Parodi
authors.forename: M
authors.initials: M
authors.lastname: Marugo
authors.forename: G
authors.initials: G
authors.lastname: Ciancamerla
authors.forename: R
authors.initials: R
authors.lastname: Santucci
authors.forename: L
authors.initials: L
authors.lastname: Fazzuoli
mesh_terms: D000328:Adult; D015237:Dinoprost / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D004415:Dyspepsia / Q000378:metabolism*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000378:metabolism*
chemical_list: D015237:Dinoprost; D015232:Dinoprostone