Image processing by microcomputer on ultrastructure of griseofulvin-resistant fungi in favus.
The ultrastructure of 5 griseofulvin-resistant fungi of favus was studied by image processing with microcomputer. It was found that the cell walls of the fungi consisted of 8 layers, and the inner layer containing cytoplasm was loose. It was also found that all structures within the cytoplasm possessed a 1-3 layers integral envelope with chromatins in the nucleus. These might be contributing factors in the development of resistance to griseofulvin. This multiple-layered, thick cell wall might act as a barrier responsible for the impermeability of the cell to griseofulvin.
Zheng
Y C
YC
Department of Dermatology, Xiehe Hospital, Tongji Medical University, Wuhan.
Zhu
Z R
ZR
Liang
P J
PJ
Chen
J F
JF
D004352:Drug Resistance, Microbial; D006118:Griseofulvin / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008838:Microcomputers; D008854:Microscopy, Electron; D014007:Tinea Favosa / Q000382:microbiology; D014249:Trichophyton / Q000187:drug effects / Q000648:ultrastructure*
D006118:Griseofulvin