Clinical and clinicopathologic effects of samarium-153-EDTMP administered intravenously to normal beagle dogs.
A study was undertaken to determine the degree of acute bone marrow and vital organs injury sustained when dogs were administered doses of 153Sm-EDTMP calculated to irradiate an acute bone lesion arising from cancer metastasis to a dose considered palliative or even therapeutic (20-160 Gy). The study revealed significant (p less than 0.05) temporary depression of the bone marrow in all doses in the therapeutic (greater than 40 Gy) range. Palliative (20 Gy) doses caused significant leukocyte depression but insignificant (p greater than 0.05) depression of platelet and packed cell volumes when compared to control animals. A mild transient rise in the levels of serum alkaline phosphatase occurred immediately following radioisotope administration. All hematologic parameters had returned to normal by six weeks after the last injection of radioisotope. The study indicates potential for this compound as a safe, therapeutic radiopharmaceutical for treatment of cancer bone metastasis.
Lattimer
J C
JC
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211.
Corwin
L A
LA
Stapleton
J
J
Volkert
W A
WA
Ehrhardt
G J
GJ
Ketring
A R
AR
Hewett
J E
JE
Simon
J
J
Goeckeler
W F
WF
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007958:Leukocyte Count / Q000528:radiation effects; D008297:Male; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D011868:Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D012493:Samarium / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity
D009943:Organophosphorus Compounds; D011868:Radioisotopes; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D012493:Samarium; D000469:Alkaline Phosphatase