Antinociceptive effects of oriental medicine kei-kyoh-zoh-soh-oh-shin-bu-toh in mice and rats.
Antinociceptive effects of peroral administration of an oriental medicine Kei-Kyoh-Zoh-Soh-Oh-Shin-Bu-toh (TJ-8023) were examined using rats and mice. TJ-8023 (100 mg.kg-1.d-1) inhibited the induction of adjuvant-induced hyperalgesia of rats in the paw-pressure test following prophylactic administration, and normalized the nociceptive threshold at a dose of 600 mg.kg-1.d-1, without effects on adjuvant-induced inflammation. Mice suffering from repeated cold stress showed a decrease in nociceptive threshold for tail-pressure stimulation. Such a hyperalgesia was reversed by a single (30 and 100 mg/kg) or repeated administration (100 and 300 mg.kg-1.d-1) of TJ-8023. The nociceptive threshold of non-stressed mice was not affected by TJ-8023 (100 mg/kg). Nociceptive responses of mice to cold-plate stimulation were also not affected by repeated administration of TJ-8023 (300, 600 and 1200 mg.kg-1.d-1). The present results demonstrate the antinociceptive action of TJ-8023, and suggest that it is more effective in easing a hyperalgesia in morbid state than in suppressing a nociception in the normal one.
Kuraishi
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Nanayama
T
T
Yamauchi
T
T
Hotani
T
T
Satoh
M
M
D000276:Adjuvants, Immunologic; D000700:Analgesics; D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006930:Hyperalgesia / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological
D000276:Adjuvants, Immunologic; D000700:Analgesics; D004365:Drugs, Chinese Herbal; C064280:kei-kyoh-zoh-soh-oh-shin-bu-toh