title: [Topical anesthesia of the tympanic membrane using DMSO and local anesthetics].
abstract: A solution of 10% cocaine hydrochloride plus 10% water in 80% dimethyl sulfoxide (DMSO) or 5% tetracaine base in pure DMSO was topically applied to the eardrum in 112 and 52 cases respectively. Both preparations induced well-tolerated analgesia suitable for myringotomy with or without insertion of a grommet in the office environment. DMSO-tetracaine induced analgesia within ten, DMSO-cocaine within 30 minutes. This method has distinct advantages as compared to iontophoretically induced analgesia or topical agents with a destructive mode of action.
authors.affiliation: Hals-Nasen-Ohren-Klinik, Medizinischen Universität zu Lübeck.
authors.forename: R E
authors.initials: RE
authors.lastname: Blessing
authors.forename: W W
authors.initials: WW
authors.lastname: Schlenter
mesh_terms: D000287:Administration, Topical; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D006801:Humans; D008876:Middle Ear Ventilation; D014432:Tympanic Membrane / Q000601:surgery*; D014433:Tympanoplasty
chemical_list: D000779:Anesthetics, Local; D004121:Dimethyl Sulfoxide
vernacular_title: Oberflächenanästhesie des Trommelfells mit DMSO und Lokalanästhetika.