Effects of coumarins, haematoporphyrins and acridine orange on the viability and growth of Landshütz ascites tumour cells, in the presence and absence of photoradiation.
The effects of haematoporphyrin (Hp), haematoporphyrin derivative (HpD), coumarin, 7-hydroxycoumarin, 4-hydroxycoumarin, amino-methyl-coumarin acetic acid and acridine orange, with and without photoradiation, on Landschutz ascites tumour (LAT) cells were examined. Hp, HpD and acridine orange showed a significant effect on LAT cell viability following photoradiation. However, coumarin or its derivatives had no significant effect on LAT cell viability, with or without photoradiation, over 18 h. Coumarin alone had a significant effect on viability of LAT cells, in vitro, over a period of 9 days. This effect was verified by transplantability studies. Coumarin and 7-hydroxycoumarin both exhibited cytostatic effects on LAT cell growth.
Prosser
E
E
School of Biological Sciences, Dublin City University, Republic of Ireland.
Cox
D
D
O'Kennedy
R
R
Carroll
K
K
van der Putten
W
W
D000165:Acridine Orange / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006415:Hematoporphyrins / Q000494:pharmacology*; D008027:Light; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D003374:Coumarins; D006415:Hematoporphyrins; D000165:Acridine Orange