[Alloimmune thrombocytopenia in the newborn infant caused by maternal PlA1 antibodies].
The case of pregnant woman, whose first child was born with neonatal alloimmune thrombocytopenia (NATP) and PlA2/PlA1 constellation, is used as an example to draw up a programme for the care of pregnant women whose children are expected to be born with NATP. In one of 2,000 to one of 3,000 cases, the PlA1-positive foetal platelets cause a sensitization of the PlA1-negative mother. Transplacental passage of maternal IgG alloantibodies leads to accelerated destruction of foetal platelets. The pathophysiologic process is similar to Rh-erythroblastosis foetalis. The infants show symptoms ranging from cutaneous manifestations to intracranial haemorrhages.
Neuhaus
W
W
Frauenklinik, Universität Köln.
Sehrbundt
M
M
Bolte
A
A
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D005260:Female; D006474:Hemorrhagic Disorders / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis*; D007519:Isoantigens / Q000276:immunology*; D010976:Platelet Count; D017713:Platelet Transfusion; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology* / Q000628:therapy
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens
Alloimmunthrombozytopenie beim Neugeborenen aufgrund mütterlicher Anti-PlA1-Antikörper.