Premature coronary artery disease and the Prader-Willi syndrome.
A 28 year old woman with the Prader-Willi syndrome developed chest pain and loss of anterior R wave amplitude on the electrocardiogram. Cardiac catheterization demonstrated a severe proximal stenosis of the left anterior descending artery with delayed antegrade flow together with antero-apical akinesia consistent with myocardial infarction. Physicians involved in the management of patients with the Prader-Willi syndrome should be aware of this association with premature coronary artery disease.
Page
S R
SR
Department of Medicine, St George's Hospital Medical School, London, UK.
Nussey
S S
SS
Haywood
G A
GA
Jenkins
J S
JS
D000328:Adult; D003327:Coronary Disease / Q000150:complications* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications; D011218:Prader-Willi Syndrome / Q000150:complications*