Verapamil inhibits proliferation but not steroidogenesis of regenerating rat adrenal cortex.
The effect of verapamil, a calcium channel antagonist, on proliferation and steroidogenesis was investigated in regenerating rat adrenal cortex. Verapamil was given subcutaneously in two doses (1 and 5 mg/kg) to male Wistar rats subjected to adrenal enucleation combined with contralateral adrenalectomy. It was found that verapamil inhibited the mitotic activity of adrenocortical cells on the 4th and 8th day after surgery in a dose-dependent manner. However, no changes in corticosterone secretion were observed.
Zieleniewski
W
W
Department of Clinical Endocrinology, Institute of Endocrinology, Lodz, Poland.
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003345:Corticosterone / Q000096:biosynthesis* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D003345:Corticosterone