[A study on pathogen antigen and serodiagnosis of Malleus and Melioidosis with McAbs].
A study on pathogen antigen and serodiagnosis of Malleus and Mlioidosis was made with McAbs which are against Ps. mallei or Ps. pseudomallei. The results showed that (1) Ps. mallei and Ps. pseudomallei express different surface antigen types respectively, and there are antigen overlapping in some degree between them; (2) Epitope 2D4 is common to Ps. mallei and Ps. pseudomallei; (3) The antibody which is similar to McAbs 4D4 or 1A9 might be a common serum antibody of Malleus and Melioidosis; and (4) McAb 3A1 is a high specific one which reacts with Ps. pseudomallei only, and with it, it is possible to resolve the immunological problem of distinguishing diagnosis between Malleus and Melioidosis.
Zhao
J
J
The Military Veterinary Institute, Veterinary College of PLA, Changchun.
Liu
Z
Z
Ma
C
C
Deng
D
D
D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D003937:Diagnosis, Differential; D008554:Melioidosis / Q000175:diagnosis; D011549:Pseudomonas / Q000145:classification / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000954:Antigens, Surface