Chronic beta-carotene supplementation does not alter the gastric mucosal response to acute aspirin ingestion.
Carotenoids and retinoids have been reported to reduce gastrointestinal mucosa damage from a variety of irritants. We performed double-blind, placebo-controlled endoscopic trial to evaluate the effect of chronic beta-carotene supplementation upon the gastric mucosal response to acute aspirin injury. Six subjects taking chronic beta-carotene and six taking placebo each ingested 650 mg of aspirin after an endoscopy confirmed normal gastric mucosa. Three hours later, mucosal lesions were counted at repeat endoscopy. beta-Carotene did not prevent acute mucosal injury better than placebo.
Moses
F M
FM
Gastroenterology Service, Walter Reed Army Medical Center, Washington, D.C. 20307-5001.
Kikendall
J W
JW
Bowen
P
P
Young
T R
TR
D000208:Acute Disease; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000517:prevention & control; D019207:beta Carotene
D019207:beta Carotene; D002338:Carotenoids; D001241:Aspirin