Rearrangement of band 10q22 in leiomyoma and leiomyosarcoma of the uterus.
Cytogenetic analysis of a uterine leiomyoma from a 56-year-old woman revealed an interstitial deletion of chromosome 10, del(10)(q22q24), as the only chromosomal abnormality. Band 10q22 was also rearranged in a previously reported leiomyosarcoma of the uterus showing a t(10;17)(q22.1;p13) as the only change. These findings provide an additional example in soft tissue tumors for involvement of the same chromosomal regions in benign and malignant proliferation of cells from the same lineage.
Kiechle-Schwarz
M
M
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Berger
C S
CS
Surti
U
U
Sandberg
A A
AA
D002871:Chromosome Banding; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D007890:Leiomyosarcoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*