[Cardiodepressor agents in the blood of burn patients and an assessment of the efficacy of their elimination].
The effect of hemosorption (HS) on cardiodepressor activity of plasma deproteinates (PD) and plasma level of medium-size molecular peptides (MSMP) has been studied, using microbiuret technique, in 14 patients with thermic burns (group I--moderate burns, group II--severe burns). Cardiac screening was performed on the isolated papillary muscle. It has been established that on the first day after HS in patients of group I normalization of MSMP level is accompanied by the disappearance of PD cardiodepressor effect and the recovery of positive inotropic effect, which is typical of healthy donors. In patients of group II the changes were not so marked, which is associated with a sufficiently high MSMP level 24 h after HS and its direct negative inotropic effect in burns. The data obtained indicate that HS is pathogenetically grounded for the correction of damaged myocardial contractility in burn-induced toxemia, as it eliminates cardiodepressor agents from blood.
Puzhevskiĭ
A S
AS
Lifshits
R I
RI
D000328:Adult; D000818:Animals; D002056:Burns / Q000097:blood* / Q000150:complications / Q000628:therapy; D003864:Depression, Chemical; D006321:Heart / Q000187:drug effects*; D006464:Hemoperfusion; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D008970:Molecular Weight; D009200:Myocardial Contraction / Q000187:drug effects; D010455:Peptides / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D014115:Toxemia / Q000097:blood / Q000209:etiology / Q000628:therapy
D010455:Peptides
Kardiodepressornye agenty krovi obozhzhennykh i otsenka éffektivnosti ikh éliminatsii.