[Analysis of dynamic changes in glycosylated blood proteins using a computer model].
The authors elaborated a computer model of albumin glycosylation based on the irreversible glycosylation reaction with first order kinetics. The dynamics of changes of glycosylated albumin in relation to the glycaemic profile was confirmed with an older model of haemoglobin glycosylation. By means of regression analysis parameters of the model in three groups of patients were calculated.


CONCLUSIONS
1. Stratification of the red cell pool is the reason why there is a smaller clinical difference between glycosylated protein and haemoglobin than corresponds to their half-times. 2. Glycosylated proteins are probably eliminated more rapidly than non-glycosylated ones. 3. Higher levels of glycosylated proteins sometimes do not correspond to model calculations are probably due to other factors.
Svacina
S
S
III. interní katedra fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Hovorka
R
R
Skrha
J
J
Masek
Z
Z
D003198:Computer Simulation; D019270:Fructosamine; D006031:Glycosylation; D006595:Hexosamines / Q000378:metabolism; D006801:Humans; D012709:Serum Albumin / Q000378:metabolism*
D006595:Hexosamines; D012709:Serum Albumin; D019270:Fructosamine
Analýza dynamických zmĕn glykovaných proteinů v séru uzitím pocítacového modelu.