title: [Acute toloxatone poisoning. Apropos of 122 cases].
abstract: Toloxatone is a new monoamine oxidase inhibitor. One hundred and twenty two cases of poisoning with this drug are reported. In this series, the minimal toxic dose was 2 g. The first symptoms appeared about one hour after ingestion. In most cases, only drowsiness and mild adrenergic effects were observed. In a few cases of massive overdose, coma, pyramidal irritation, and myoclonic jerks occurred. In 3 cases of severe poisoning, toloxatone was associated with tricyclic antidepressants. Symptoms were similar to those reported in intoxications associating classical monoamine oxidase inhibitors and tricyclic antidepressants: muscular rigidity, hyperthermia and cardiovascular collapse. Two of these patients died.
authors.affiliation: Centre Anti-Poisons de Paris, Hôpital Fernand Widal, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Azoyan
authors.forename: R
authors.initials: R
authors.lastname: Garnier
authors.forename: F J
authors.initials: FJ
authors.lastname: Baud
authors.forename: M L
authors.initials: ML
authors.lastname: Efthymiou
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000506:poisoning*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced; D010080:Oxazoles / Q000506:poisoning*; D023303:Oxazolidinones; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D010080:Oxazoles; D023303:Oxazolidinones; C010798:toloxatone
vernacular_title: Intoxication aiguë par la toloxatone. A propos de 122 observations.