title: [Characterization and pharmacological effect on brain damage as a result of cold injury].
abstract: Freezing lesion of brain damages the blood-brain-barrier and induces edema. Both injuries are partially separate processes with different progress and diverse response to pharmacological treatment. A very weak lesion fails in to induce edema despite of an enhanced permeation of Evans blue. The injured permeability responds to treatment with dexamethasone or piracetam whereas the edema does not.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Medizinische Akademie Carl Gustav Carus Dresden.
authors.forename: K F
authors.initials: KF
authors.lastname: Funk
authors.forename: E
authors.initials: E
authors.lastname: Rudolph
authors.forename: M
authors.initials: M
authors.lastname: Blaschke
authors.forename: H D
authors.initials: HD
authors.lastname: Fischer
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000209:etiology*; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005070:Evans Blue; D005615:Freezing; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011760:Pyrrolidinones; D005070:Evans Blue; D003907:Dexamethasone; D010889:Piracetam
vernacular_title: Zur Charakterisierung und pharmakologischen Beeinflussung der durch Kryoläsion ausgelösten Hirnschäden.