[Anti-aggregatory and anticoagulant properties of oligoamines. 11. Oligoamines with two primary amine groups].
Ten branched alpha,omega-alkanediamines with two primary amino groups have been synthesized and tested for their antiplatelet and anticoagulant effects. Seven of them inhibited the platelet aggregation induced by collagen at an IC50 ranging from 5-11 mumol/L. In concentrations up to 400 mumol/L the one stage thromboplastin time was only slightly prolonged (delta t less than 7s).
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin.
Rose
B
B
Leissring
S
S
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000925:Anticoagulants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*
D000588:Amines; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 11. Mitt.: Oligoamine mit zwei primären Aminogruppen.