title: Research on psychotropic agents. III. Antidepressant activity and neuropsychobehavioural effects of new 5H-Pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives.
abstract: The synthesis of 5H-pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives related to imipramine and aptazepine antidepressant agents is reported. Pharmacological screening on new tricyclic derivatives showed that in some cases antidepressant effects at equimolecular dose with imipramine are associated with sedative-muscle relaxant activities and antinociception.
authors.affiliation: Dipartimento di Studi Farmaceutici, Facoltà di Farmacia, Università di Roma La Sapienza.
authors.forename: G
authors.initials: G
authors.lastname: Stefancich
authors.forename: M
authors.initials: M
authors.lastname: Artico
authors.forename: R
authors.initials: R
authors.lastname: Silvestri
authors.forename: G C
authors.initials: GC
authors.lastname: Pantaleoni
authors.forename: R
authors.initials: R
authors.lastname: Giorgi
authors.forename: G
authors.initials: G
authors.lastname: Palumbo
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central; D010146:Pain / Q000188:drug therapy; D004856:Postural Balance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D001552:Benzazepines; D009125:Muscle Relaxants, Central; D011619:Psychotropic Drugs; D011758:Pyrroles