[Changes in the levels of erythrocyte membrane proteins in hypertension].
The distribution of specific proteins in erythrocyte membranes was studied in patients with essential hypertension (EH) (n = 44), secondary hypertension of renal genesis (n = 42), and healthy persons (n = 44). Densitograms of gel analyzed after electrophoresis of erythrocyte ghosts showed a twofold increase in polypeptide levels in EH patients as compared to those in health persons: the band being 4.5 (Mw = 52-59 kD) and 6 (Mw = 35 kD), respectively. Radioimmunoassay has demonstrated that the amount of monoclonal antibodies bound to fragmented erythrocyte membranes from EH patients is greater by at least 28% than that in healthy persons. Patients with secondary arterial hypertension of renal genesis showed no significant difference in monoclonal antibody binding as compared to the controls.
Loginov
V A
VA
Sukhoplechev
S A
SA
Minchenko
B I
BI
Aleksandrov
A A
AA
Oganov
R G
RG
D000328:Adult; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood*; D015151:Immunoblotting / Q000379:methods; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000150:complications
D008565:Membrane Proteins
Izmenenie kolichestvennogo sootnosheniia membrannykh belkov éritrotsitov pri gipertonicheskoĭ bolezni.