title: Lacrimal gland dosimetry for the brain imaging agent technetium-99m-HMPAO.
abstract: We calculated lacrimal gland dosimetry for the brain imaging agent 99mTc-HMPAO. One hundred thirty-eight patients were studied using a dedicated brain imaging device. Only 11% of the patients showed lacrimal gland uptake. For a 740-MBq (20 mCi) injected dose of 99mTc-HMPAO, the radiation exposure to the lacrimal glands is 10.2 mGy (1.02 rad), or 0.0138 mGy/MBq (0.051 rad/mCi). These values are five times lower than the ones reported by the manufacturer of HMPAO. As the dosimetry calculation is only for subjects showing 99mTc-HMPAO uptake in the lacrimal gland, the average radiation dose to all subjects is considerably lower, 1/10 of the estimated value.
authors.affiliation: Division of Nuclear Medicine, Harbor-UCLA Medical Center, Torrance, California.
authors.forename: J
authors.initials: J
authors.lastname: Villanueva-Meyer
authors.forename: D
authors.initials: D
authors.lastname: Thompson
authors.forename: I
authors.initials: I
authors.lastname: Mena
authors.forename: C S
authors.initials: CS
authors.lastname: Marcus
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D007765:Lacrimal Apparatus / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010091:Oximes; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime