title: Model of redox regulation of hyper- or hypothyreoidism.
abstract: Since the triiodothyronine (T3) shifts the tissue metabolism to oxidative direction, one should await that in hyperthyreoidism caused by T3 an oxidosis will be formed, whilst in hypothyreoidism called forth by subtotal thyreoidectomy, redosis will be emerged. However, according to our experiments these interrelationships proved to be inverse. These "paradoxal" changes of redox-state are the consequences of the flowing redox compensations elicited by the tissue redox-buffer capacity (RBC). The pathomechanism can be modelled with differential equation (computer analysis). The redox-state changes are characteristics in each tissues. Between the RBC of the tissue and the shift of redox-state potential (E'0) there is a negative correlation. As an autoregulatory mechanims, the redosis formed in hyperthyreoidism will increase the hormone synthesis in the thyroid gland, while the oxidosis after hypothyreoidism will decrease the synthesis. In other words, these processes strengthen each other. Changes of the heart frequency show correlation with the E'0, and can be described by differential equation. Our theoretical model for the redox regulation might answer also the question of the reversibility-irreversibility range of the autoregulation in the pathomechanism.
authors.affiliation: Hospital of Local Board, Karcag, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Prager
authors.forename: A
authors.initials: A
authors.lastname: Puppi
authors.forename: M
authors.initials: M
authors.lastname: Gabriel
authors.forename: M
authors.initials: M
authors.lastname: Dely
authors.forename: M
authors.initials: M
authors.lastname: Mandi
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D007037:Hypothyroidism / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D010084:Oxidation-Reduction; D051381:Rats; D013965:Thyroidectomy; D014284:Triiodothyronine
chemical_list: D014284:Triiodothyronine