[The mechanisms of the inhibition of erythrocyte acetylcholinesterase activity by photodynamic herbicides].
A comparative study of kinetics and mechanisms of action of some photodynamic herbicides (dipyridil, phenantroline, and acepox) on mechanical resistance and acetylcholinesterase activity of erythrocytes has been carried out. Acepox had a slight damaging effect, and phenantroline was the strongest inhibitor. The data on mechanical destruction of erythrocytes correlated with tests on toxicity of obtained samples carried out on mice and infusorians. The proposed criteria may help to search for nontoxic drugs.
Braginskaia
F I
FI
Zorina
O M
OM
Borodiuk
N R
NR
Kartsev
V G
VG
D015082:2,2'-Dipyridyl / Q000494:pharmacology; D000110:Acetylcholinesterase / Q000097:blood*; D002800:Cholinesterase Inhibitors; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology; D006461:Hemolysis / Q000502:physiology; D006540:Herbicides / Q000494:pharmacology*; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects; D066298:In Vitro Techniques; D010618:Phenanthrolines / Q000494:pharmacology; D014465:Ultrasonics
D002800:Cholinesterase Inhibitors; D006540:Herbicides; D010618:Phenanthrolines; D015082:2,2'-Dipyridyl; D000110:Acetylcholinesterase; C025205:1,10-phenanthroline
Mekhanizmy tormozheniia aktivnosti éritrotsitarnoĭ atsetilkholinésterazy nekotorymi fotodinamicheskimi gerbitsidami.