Antigenic expression of cathepsin B in aged human brain.
The lysosomal thiol proteinase, cathepsin B, has been localized in different regions of aged human brain by use of the peroxidase-antiperoxidase technique. Cathepsin B-immunoreactive material was detected in multiple neurons of human hippocampus, neocortical area A 10, prefrontal gyrus and nuc. basalis of Meynert as well as in single white matter astrocytes. In brains of Alzheimer disease-affected subjects cathepsin B was revealed in neuritic plaques too. Possible functional consequences with regard to normal aging, neuropeptide metabolism and pathological changes are discussed.
Bernstein
H G
HG
Institute of Anatomy, Medical Academy Magdeburg, GDR.
Kirschke
H
H
Wiederanders
B
B
Schmidt
D
D
Rinne
A
A
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D002401:Cathepsin B / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D002401:Cathepsin B