Potentiation of cocaine's discriminative effects by caffeine: a time-effect analysis.
The effects of caffeine upon the discriminative and rate-altering effects of cocaine were examined in rats. Using a food-reinforced two-lever operant procedure, 12 male Sprague-Dawley rats were trained to discriminate between 10 mg/kg cocaine and saline. Time-effect analysis of the training dose resulted in a median effective time interval (the duration of the discriminable effects of cocaine in producing 50% cocaine-appropriate responding), of 60.5 minutes postinjection. Caffeine partially generalized to the cocaine stimulus and, when administered with cocaine, produced a dose- and time-dependent increase in the percentage of drug-appropriate responding. Data are discussed with reference to our previous results with cocaine-caffeine interactions.
Gauvin
D V
DV
University of Oklahoma Health Sciences Center, Department of Psychiatry and Behavioral Sciences, Oklahoma City 73190-3000.
Criado
J R
JR
Moore
K R
KR
Holloway
F A
FA
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004357:Drug Synergism; D005795:Generalization, Stimulus; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002110:Caffeine; D003042:Cocaine