[Idiopathic arterial calcification: its link with calciphylaxis].
The attempt to establish the connection of the idiopathic arterial calcification (IAC) with calciphilaxy is made on the basis of the published data analysis and 11 observations of IAC in children. Apart from known morphological manifestations of IAC, the authors found mast cells in the cellular infiltrate, vesicular transformation of smooth cells in the arteries affected. This together with the elastic membrane changes in the arteries and massive iron and oxyapatite deposits in the arterial wall suggests the development of calciphylactic reaction. The similarity of the morphological and clinical manifestations, and IAK therapy in the clinics and experiment is shown. Special emphasis is made on the possibility of the calciphylaxy development in children under conditions of the vitamin D wide use for the prevention of rickets and iron preparations use for anemia treatment. The conclusion is drawn on the multicausal character of IAK and possibility to distinguish congenital, acquired and combined forms of the disease. The necessity of through analysis of each case of IAK is stressed in order to reveal iatrogenic factors capable to produce sensibilization and/or to provoke the disease.
Khodasevich
L S
LS
Osipov
S M
SM
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000473:pathology; D001158:Arteries / Q000473:pathology; D002114:Calcinosis / Q000209:etiology* / Q000473:pathology; D002115:Calciphylaxis / Q000209:etiology* / Q000473:pathology; D003645:Death, Sudden / Q000209:etiology / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size
Idiopaticheskaia arterial'naia kal'tsifikatsiiia: sviaz' s kal'tsifilaksieĭ.