title: Isolation of fatty acid amide as an angiogenic principle from bovine mesentery.
abstract: Erucamide (13-docosenamide) was found to be the major bovine mesentery angiogenic lipid as assessed by chorioallantoic membrane (CAM) assay. Two micrograms of this lipid caused angiogenesis in the assay. Angiogenic activity of this naturally occurring lipid was also found by rat corneal micropocket and mouse dorsal air-sac assays. Specificity of the chemical structure which elicited activity was low, however. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.
authors.affiliation: Tsukuba Research Laboratories, Takeda Chemical Industries Ltd., Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wakamatsu
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: F
authors.initials: F
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Sudo
mesh_terms: D043925:Angiogenesis Inducing Agents; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D004727:Endothelium; D004883:Erucic Acids / Q000378:metabolism / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D006133:Growth Substances; D008643:Mesentery / Q000032:analysis*; D051379:Mice; D051381:Rats
chemical_list: D043925:Angiogenesis Inducing Agents; D004883:Erucic Acids; D005229:Fatty Acids, Monounsaturated; D006133:Growth Substances; C049508:erucyl amide