Anticoccidial efficacy of diclazuril in pheasants.
Diclazuril, a new anticoccidial drug, was tested in young pheasants artificially infected with the three most common pathogenic species of Eimeria, E colchici, E duodenalis and E phasiani. In two replicate experiments each with 40 birds the mortalities in the infected controls were 50 and 25 per cent. Diclazuril was administered in the feed at dose levels of 1, 2 and 4 ppm from the day before the inoculation of coccidia until the end of the test on day 6 after infection. The 1 ppm dose failed to inhibit the development of the parasite completely, as was shown by a reduction of the weight gain of the birds and the output of a small number of oocysts. Diclazuril at 2 or 4 ppm adequately controlled the infection, with weight gains similar to those of the uninfected controls. At all dose levels, mortality, intestinal lesions and diarrhoea were prevented.
Vanparijs
O
O
Department of Parasitology, Janssen Pharmaceutica, Beerse, Belgium.
Hermans
L
L
Marsboom
R
R
D000818:Animals; D001715:Bird Diseases / Q000188:drug therapy*; D001717:Birds; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005243:Feces / Q000469:parasitology; D009570:Nitriles / Q000627:therapeutic use*; D014227:Triazines / Q000627:therapeutic use*; D015430:Weight Gain
D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril