Evaluation of cytochrome P-450 mediated metabolism of antipyrine in the rat at different extents of fluosol-DA hemodilution.
Two reports of antipyrine disposition in rats after hemodilution with 20, 40, or 80 ml/kg of Fluosol-DA are evaluated to determine if the extent of hemodilution influenced cytochrome P-450 mediated antipyrine metabolism. Alterations in antipyrine clearance (Cl) and 3-hydroxymethylantipyrine (3OHME) formation clearance (ClF) show that the extent of Fluosol hemodilution influences both the time and pattern of change in cytochrome P-450 isoenzyme activity. Alterations in antipyrine Vd had no consistent pattern with different extents of hemodilution.
Shrewsbury
R P
RP
School of Pharmacy, University of North Carolina, Chapel Hill 27599.
White
L G
LG
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D001802:Blood Substitutes; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D004338:Drug Combinations; D005466:Fluorocarbons; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives; D008657:Metabolic Clearance Rate / Q000502:physiology; D051381:Rats
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D003577:Cytochrome P-450 Enzyme System; D000983:Antipyrine