title: Human sperm chromosomes. Long-term effect of cancer treatment.
abstract: The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa.
authors.affiliation: Departament de Biologia Cel.lular i Fisiologia, Universitat Autònoma de Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Genescà
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: J
authors.initials: J
authors.lastname: Benet
authors.forename: X
authors.initials: X
authors.lastname: Bonfill
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011832:Radiation Injuries / Q000235:genetics; D013094:Spermatozoa / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents