[Characterization and pharmacological effect on brain damage as a result of cold injury].
Freezing lesion of brain damages the blood-brain-barrier and induces edema. Both injuries are partially separate processes with different progress and diverse response to pharmacological treatment. A very weak lesion fails in to induce edema despite of an enhanced permeation of Evans blue. The injured permeability responds to treatment with dexamethasone or piracetam whereas the edema does not.
Funk
K F
KF
Institut für Pharmakologie und Toxikologie, Medizinische Akademie Carl Gustav Carus Dresden.
Rudolph
E
E
Blaschke
M
M
Fischer
H D
HD
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000209:etiology*; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005070:Evans Blue; D005615:Freezing; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011760:Pyrrolidinones; D005070:Evans Blue; D003907:Dexamethasone; D010889:Piracetam
Zur Charakterisierung und pharmakologischen Beeinflussung der durch Kryoläsion ausgelösten Hirnschäden.