title: Anastomotic stricture following repair of esophageal atresia.
abstract: Anastomotic strictures developed in 74 (37.2%) of 199 patients undergoing primary or delayed primary repair of esophageal atresia with or without tracheoesophageal fistula. Significant predisposing factors included the use of braided silk sutures (relative risk 1.72 and 1.49, compared with polyglycolic acid and polypropylene sutures), the presence of gastroesophageal reflux and leakage of the anastomosis (relative risk 2.29 and 2.04, respectively). Tracheomalacia, personnel factors, and recurrent fistula did not affect the rate of stricture formation. Seventy-one patients responded to dilatation alone, whereas three required stricture resection or esophageal substitution. All three patients requiring surgical intervention and 14 requiring five or more dilatations developed symptoms within the first 6 months after esophageal anastomosis. Antireflux surgery was carried out in 19 (25.7%) of the 74 patients.
authors.affiliation: Hospital for Sick Children, London, England.
authors.forename: S
authors.initials: S
authors.lastname: Chittmittrapap
authors.forename: L
authors.initials: L
authors.lastname: Spitz
authors.forename: E M
authors.initials: EM
authors.lastname: Kiely
authors.forename: R J
authors.initials: RJ
authors.lastname: Brereton
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects; D004933:Esophageal Atresia / Q000601:surgery*; D004940:Esophageal Stenosis / Q000209:etiology*; D006801:Humans; D007223:Infant; D019476:Insect Proteins; D011506:Proteins / Q000009:adverse effects; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D047011:Silk; D014138:Tracheoesophageal Fistula / Q000209:etiology*
chemical_list: D019476:Insect Proteins; D011506:Proteins; D047011:Silk