Evidence against the reported linkage of the cutaneous melanoma-dysplastic nevus syndrome locus to chromosome Ip36.
The reported linkage between cutaneous melanoma and the dysplastic nevus syndrome (CM/DNS) to markers located on the distal portion of the short arm of chromosome 1 was examined in three Utah kindreds ascertained for multiple cases of melanoma. Family members in these kindreds were genotyped for the two markers reported to be most closely linked in the Bale study, PND and D1S47. Both melanoma alone and a combined melanoma/DNS phenotype were analyzed; no evidence for linkage was found. By multipoint linkage analysis the CM/DNS locus was excluded from an area of 55 cM containing the PND-D1S47 region. Diagnostic or genetic heterogeneity are alternate explanations for the discrepancy between our observations and those of Bale et al.
Cannon-Albright
L A
LA
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.
Goldgar
D E
DE
Wright
E C
EC
Turco
A
A
Jost
M
M
Meyer
L J
LJ
Piepkorn
M
M
Zone
J J
JJ
Skolnick
M H
MH
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004416:Dysplastic Nevus Syndrome / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D008545:Melanoma / Q000235:genetics*; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics*; D013577:Syndrome