title: Gastrointestinal motility enhancing effect of ginger and its active constituents.
abstract: The effect of ginger root (Zingiberis Rhizoma) on gastrointestinal motility was examined based on its ability to enhance charcoal meal transport in mice. Oral administrations of the acetone extract of ginger (which contains volatile oils and bitter substances) at 75 mg/kg, [6]-shogaol at 2.5 mg/kg, or a [6]-, [8]- or [10]-gingerol at 5 mg/kg enhanced the transport of a charcoal meal. The effects of these substances were similar to or slightly weaker than those of metoclopramide and donperidone.
authors.affiliation: Kyoto Pharmacological University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: Q R
authors.initials: QR
authors.lastname: Huang
authors.forename: Y H
authors.initials: YH
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Fujimura
mesh_terms: D000818:Animals; D002396:Catechols / Q000494:pharmacology; D003212:Condiments / Q000032:analysis*; D005233:Fatty Alcohols / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; D010936:Plant Extracts; C040115:shogaol; C007845:gingerol