Seizure activity with imipenem therapy: incidence and risk factors.
Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while receiving maximum doses of imipenem/cilastatin. Neither patient had reported previous seizures or seizure-like activity nor was receiving anticonvulsant agents. All seizures were controlled with therapeutic doses of phenytoin. Both patients had received maximum doses of other beta-lactam antibiotics without evidence of seizure activity.
Job
M L
ML
Department of Pharmacy Practice, Mercer University School of Pharmacy, Atlanta, GA 30312.
Dretler
R H
RH
D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D015378:Imipenem / Q000009:adverse effects* / Q000627:therapeutic use; D007592:Joint Diseases / Q000188:drug therapy; D007719:Knee Joint; D008297:Male; D011014:Pneumonia / Q000188:drug therapy; D012307:Risk Factors; D012640:Seizures / Q000139:chemically induced*
D015378:Imipenem