Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin).
Survival of mice after lethal doses of lyophilizate from Amanita phalloides ('death cap') was markedly increased by pretreatment with single doses of kutkin, a mixture of iridoid glycosides picroside I and kutkoside isolated from the roots of Picrorhiza kurroa. The protective effect of kutkin was comparable to that of silibinin. The curative efficacy of kutkin appeared to be slightly superior.
Floersheim
G L
GL
Department of Research, Zentrum für Lehre und Forschung, Kantonsspital, Basel, Switzerland.
Bieri
A
A
Koenig
R
R
Pletscher
A
A
D000545:Amanita; D000818:Animals; D002934:Cinnamates / Q000627:therapeutic use*; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D062385:Hydroxybenzoates / Q000627:therapeutic use*; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy / Q000517:prevention & control*; D012838:Silymarin / Q000627:therapeutic use; D014641:Vanillic Acid / Q000627:therapeutic use*
D002934:Cinnamates; D006027:Glycosides; D062385:Hydroxybenzoates; D012838:Silymarin; C057463:kutkin; D014641:Vanillic Acid