title: [Interleukin-2 modifies the development of insulin-dependent diabetes of BB rats].
abstract: Intraperitoneal administration of human recombinant IL-2 led to a significant, dose-dependent increase and acceleration of diabetes development in BB rats, while we observed a suppression of diabetes development in animals with a high spontaneous disease incidence.
authors.affiliation: Klinische Abteilung des Diabetes-Forschungsinstituts, Universität Düsseldorf.
authors.forename: J
authors.initials: J
authors.lastname: Zielasek
authors.forename: V
authors.initials: V
authors.lastname: Burkart
authors.forename: H
authors.initials: H
authors.lastname: Kolb
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007274:Injections, Intraperitoneal; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011913:Rats, Inbred BB; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins
vernacular_title: Interleukin-2 beeinflusst die Entwicklung des insulinpflichtigen Diabetes der BB-Ratte.