Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes.
The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.
Meyne
J
J
Genetics Group, Los Alamos National Laboratory, NM 87545.
Baker
R J
RJ
Hobart
H H
HH
Hsu
T C
TC
Ryder
O A
OA
Ward
O G
OG
Wiley
J E
JE
Wurster-Hill
D H
DH
Yates
T L
TL
Moyzis
R K
RK
D000663:Amphibians / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D001717:Birds / Q000235:genetics; D002871:Chromosome Banding; D002875:Chromosomes; D004247:DNA; D005399:Fishes / Q000235:genetics; D007621:Karyotyping; D008322:Mammals / Q000235:genetics; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D012104:Reptiles / Q000235:genetics; D013045:Species Specificity; D014714:Vertebrates / Q000235:genetics*
D004247:DNA