Behavioral changes in juvenile rats after prenatal exposure to ethosuximide.
Juvenile rats 4-6 weeks old exposed prenatally at days 5-20 of gestation to ethosuximide at 10 mg/kg/dams' body weights per day were examined for behavioral abnormalities. Pinning behavior in the pups aged 4-5 weeks was significantly more frequent than that in age-matched controls. However, basal activity of open-field behavior and activity inhibited by diazepam administration in the pups aged 5-6 weeks showed no difference from the controls. The intensity of stereotyped behavior induced by apomorphine (1 mg/kg, SC) was significantly greater in the pups aged 5-6 weeks than in the controls. These results indicate that prenatal exposure to ethosuximide may cause changes in the dopaminergic neurons in the central nervous system.
Nakanishi
H
H
Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan.
Fujii
T
T
D000818:Animals; D005013:Ethosuximide / Q000494:pharmacology*; D005260:Female; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D005013:Ethosuximide