Implantable microencapsulated dopamine (DA): prolonged functional release of DA in denervated striatal tissue.
Biodegradable controlled-release microcapsule systems made with the biocompatible biodegradable polyester excipient poly [DL-lactide-co-gly-colide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microcapsules encapsulated within two different polymer excipients into denervated striatal tissue assures a prolonged release of the transmitter in vivo. This technology has a considerable potential for basic and possibly clinical research.
McRae
A
A
INSERM U-259, Bordeaux, France.
Hjorth
S
S
Mason
D
D
Dillon
L
L
Tice
T
T
D000818:Animals; D002214:Capsules; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004343:Drug Implants; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects
D002214:Capsules; D004343:Drug Implants; D011954:Receptors, Dopamine; D004298:Dopamine