title: Depletion of myocardial high energy phosphates by induction of ventricular fibrillation prior to cardioplegic arrest.
abstract: The effects of a short period of ventricular fibrillation on myocardial high energy phosphates were assessed in two groups of rats. Group 1 underwent hypothermic crystalloid cardioplegia infusion and aortic cross-clamping. In Group 2, cardioplegia and cross-clamping were preceded by ten seconds of induced ventricular fibrillation. In rat hearts that had undergone ventricular fibrillation, adenosine triphosphate levels averaged only 70% (p less than .0001) and creatine phosphate levels averaged only 60% (p less than .0005) of levels measured following standard cardioplegic arrest without ventricular fibrillation. These findings are of potential importance in both routine cardiac surgical procedures and in organ procurement.
authors.affiliation: Department of Surgery, University of Chicago Hospitals, Illinois.
authors.forename: J M
authors.initials: JM
authors.lastname: Levett
authors.forename: M H
authors.initials: MH
authors.lastname: Kadowaki
authors.forename: J H
authors.initials: JH
authors.lastname: Ip
authors.forename: R B
authors.initials: RB
authors.lastname: Karp
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D006324:Heart Arrest, Induced; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014693:Ventricular Fibrillation / Q000378:metabolism*
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate