title: The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
abstract: The growth and DNA synthesis of mouse leukemic cells L1210 in vitro was inhibited by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) by 50% at concentrations of 57.0 and 185.0 mumols/l, respectively, 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) inhibited the cell growth and DNA synthesis at concentrations of 15.5 and 250.0 mumols/l. The 2-amino congeners of the above analogs were still more efficient: The corresponding values for 2-amino-PMEA were 6.0 and 10.0 mumols/l, and for 2-amino-HPMPA 19.5 and 50.0 mumols/l, respectively. The results suggest that probably at least a part of the growth inhibitory action of PMEA is due to mechanisms not related to its interference with the DNA synthesis.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague.
authors.forename: J
authors.initials: J
authors.lastname: Veselý
authors.forename: A
authors.initials: A
authors.lastname: Merta
authors.forename: I
authors.initials: I
authors.lastname: Votruba
authors.forename: I
authors.initials: I
authors.lastname: Rosenberg
authors.forename: A
authors.initials: A
authors.lastname: Holý
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D007939:Leukemia L1210 / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C053001:adefovir; D004247:DNA; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D000225:Adenine