title: Correlation of clinical and pathological features in surgically treated craniopharyngiomas.
abstract: Surgical specimens of 104 craniopharyngiomas from 93 patients were reviewed and characterized histopathologically. They were found to have either a classic adamantinous or a squamous papillary structure. The clinical features of each group were then assessed. The frequently solid (50%), always uncalcified squamous papillary tumor type was found in one-third of the adult patients (greater than or equal to 20 years) but did not occur in children. It was associated with a good functional postoperative outcome (84.6%). There have been no cases of tumor recurrence in the squamous papillary group. However, in the group with the adamantinous type of craniopharyngioma, the recurrence rate was 13% in adult patients and 9% in children. When compared to the adult adamantinous cases, the incidence of visual deficits was lower in the squamous papillary group (75% vs. 84%) but the incidence of endocrine abnormalities was higher (75% vs. 52%). Thus, the preoperative, operative, and postoperative features of the two types of craniopharyngioma were found to be distinctly different in adults and children.
authors.affiliation: Department of Neurosurgery, University of Texas, Southwestern, Dallas.
authors.forename: T E
authors.initials: TE
authors.lastname: Adamson
authors.forename: O D
authors.initials: OD
authors.lastname: Wiestler
authors.forename: P
authors.initials: P
authors.lastname: Kleihues
authors.forename: M G
authors.initials: MG
authors.lastname: Yaşargil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004700:Endocrine System Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008722:Methods; D008875:Middle Aged; D010212:Papilloma / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D011379:Prognosis; D014786:Vision Disorders / Q000209:etiology