Changes in testis, epididymis and other accessory organs of male rats treated with anandron during sexual maturation.
Anandron (5,5-dimethyl-(4-nitro-3(trifluoromethyl)phenyl)-2,4-imidazolidine-dione ), a nonsteroidal antiandrogen was administered orally to growing rats from day 31 through day 60 of age to study its effect on the testis and genital tract. At a daily dose of 5 mg per rat, it caused a significant reduction in the weights of testis, epididymis, seminal vesicles, ventral prostate and dorsal prostate. In more than 50 percent of the animals, it caused arrest of spermatogenesis at spermatid stage. Though there was a reduction in the epididymal content of glycerylphosphorylcholine and sialic acid, their concentration was not altered much. The results are discussed in relation to the effects of anandron on the genital organs of adult male rat.
Dhar
J D
JD
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Setty
B S
BS
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D004822:Epididymis / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D005837:Genitalia, Male / Q000187:drug effects / Q000254:growth & development*; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D048289:Imidazolidines; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects / Q000254:growth & development; D012741:Sexual Maturation / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000254:growth & development*; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D007093:Imidazoles; D048289:Imidazolidines; D013739:Testosterone; C021277:nilutamide; D005997:Glycerylphosphorylcholine