Use of glycopyrrolate and atropine in acute organophosphorus poisoning.
Two cases of organophosphorus poisoning are reported. Both were treated with a combination of atropine and glycopyrrolate as well as benzodiazepine and pralidoxime. The advantages of glycopyrrolate over atropine are discussed.
Tracey
J A
JA
Poisons Information Centre, Beaumont Hospital, Dublin, Ireland.
Gallagher
H
H
D000328:Adult; D001285:Atropine / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006024:Glycopyrrolate / Q000627:therapeutic use*; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D062025:Organophosphate Poisoning; D009946:Organothiophosphorus Compounds / Q000506:poisoning; D010706:Phosmet / Q000506:poisoning; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D011759:Pyrrolidines / Q000627:therapeutic use*
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D011220:Pralidoxime Compounds; D011759:Pyrrolidines; C035019:isofenphos; D001285:Atropine; D003975:Diazepam; D008874:Midazolam; D006024:Glycopyrrolate; D010706:Phosmet