title: Aspiration pneumonitis prophylaxis in obstetric anaesthesia: comparison of effervescent cimetidine-sodium citrate mixture and sodium citrate.
abstract: One hundred and forty-seven patients undergoing elective or emergency Caesarean section under general anaesthesia were allocated randomly to three groups: group 1 (n = 28) received no premedication; group 2 (n = 58) received 0.3-molar sodium citrate 15 ml (sodium citrate 1.16 g); group 3 (n = 61) received effervescent cimetidine-sodium citrate combination (cimetidine 400 mg with sodium citrate 0.9 g) after entering the operating room. Gastric pH was measured at tracheal intubation (pH1) and extubation (pH2). Mean pH1 and mean pH2 values in group 1 were, respectively, 2.25 (SD 1.35) and 2.83 (1.64). Mean pH1 and pH2 values in group 2 were, respectively, 4.38 (1.44) and 4.57 (1.51). In group 3 mean pH1 and pH2 values were, respectively, 5.07 (1.13) and 5.37 (1.30). Percentages of patients with pH1 less than or equal to 2.5 in groups 1, 2 and 3 were, respectively, 75, 13.8 and 1.6. Percentages of patients with pH2 less than or equal to 2.5 in groups 1, 2 and 3 were 50, 10.3 and 1.6, respectively.
authors.affiliation: Département d'Anesthésie, Centre Hospitalier de Saint Nazaire, France.
authors.forename: X
authors.initials: X
authors.lastname: Ormezzano
authors.forename: T P
authors.initials: TP
authors.lastname: Francois
authors.forename: J Y
authors.initials: JY
authors.lastname: Viaud
authors.forename: J G
authors.initials: JG
authors.lastname: Bukowski
authors.forename: M C
authors.initials: MC
authors.lastname: Bourgeonneau
authors.forename: D
authors.initials: D
authors.lastname: Cottron
authors.forename: M F
authors.initials: MF
authors.lastname: Ganansia
authors.forename: F M
authors.initials: FM
authors.lastname: Gregoire
authors.forename: M R
authors.initials: MR
authors.lastname: Grinand
authors.forename: P E
authors.initials: PE
authors.lastname: Wessel
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D000863:Antacids / Q000627:therapeutic use; D002585:Cesarean Section; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use; D002951:Citrates / Q000008:administration & dosage / Q000627:therapeutic use; D019343:Citric Acid; D004338:Drug Combinations; D004341:Drug Evaluation; D004630:Emergencies; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D011015:Pneumonia, Aspiration / Q000517:prevention & control*; D011247:Pregnancy; D011292:Premedication
chemical_list: D000863:Antacids; D002951:Citrates; D004338:Drug Combinations; D019343:Citric Acid; D002927:Cimetidine