[Deficiency of prostacyclin stimulating factor in type I diabetes mellitus. Correlation with the duration of the disease].
The prostacyclin stimulating plasma factor (PSPF) was studied in 40 children affected by insulin dependent diabetes (type I), using smooth muscle cells of rat aorta as substrate. The patients were divided into three groups according to the duration of the disease; recently diagnosed patients (n = 10), patients with less than 5 years of evolution (23 cases), and patients with more than 5 years duration (n = 7). The most significant data were that all the patients with more than 5 years duration had decreased PSPF with values below I SD (p less than 0.001). No statistically significant differences were found among the group with less than 5 years duration, recently diagnosed patients and the normal control group. Neither could a correlation be found between the value of PSPF and the dose of insulin required by each patient, or the rate of hyperglycemia, triglycerides, cholesterol and Hb A1C.
Vergara
M
M
Cátedra de Pediatría, Universidad de Valladolid.
Fabra
A
A
Hermoso
F
F
Guisasola
F J
FJ
Blanco
A
A
D000293:Adolescent; D001685:Biological Factors / Q000097:blood / Q000172:deficiency*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors
D001685:Biological Factors; C057670:prostacyclin synthesis stimulating plasma factor
Deficiencia del factor estimulante de la prostaciclina en la diabetes tipo I. Correlación con la duración de la enfermedad.