Congenital smooth muscle hamartoma. Prevalence, clinical findings, and follow-up in 15 patients.
Cogenital smooth muscle hamartoma is a congenital skin lesion characterized by proliferation of bundles of smooth muscle within the reticular dermis. We report on a group of 15 children with this lesion, confirmed by skin biopsy specimen, its prevalence, the occurrence of associated anomalies, and long- term follow-up. To our knowledge, this is the largest group of patients with this lesion described in the literature. The estimated prevalence is about 1:2600 live births with slight male predominance. The lesion is most frequent in the lumbosacral area (67% [10/15]) and a positive pseudo-Darier's sign is present in 80% (12/15) of patients. During the follow-up period of up to 7 years, the lesions enlarged slightly but became less prominent. No malignant transformation was observed.
Zvulunov
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A
Pediatric Dermatology Unit, Beilinson Medical Center, Petah Tiqwa, Israel.
Rotem
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A
Merlob
P
P
Metzker
A
A
D005260:Female; D005500:Follow-Up Studies; D006222:Hamartoma / Q000151:congenital* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D008161:Lumbosacral Region; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000151:congenital* / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D012878:Skin Neoplasms / Q000151:congenital* / Q000453:epidemiology / Q000473:pathology