[Progressive multifocal leukoencephalopathy associated with leukopenia of unknown (iatrogenic?) origin].
Progressive multifocal leukoencephalopathy is a virtually always opportunistic infection of central nervous system caused by papova viruses, which clinically presents with symptoms and signs of involvement of different encephalic levels. We report a case with a double interest: on the one hand, both clinical features and lesions were limited to the brainstem and cerebellum; on the other hand, the disease developed in a previously healthy female in whom laboratory evidence of immunodeficiency of unknown origin was demonstrated. A reason for immunodeficiency was also not found at autopsy, being speculated that it could have been iatrogenically associated with antidepressant drugs.
Gómez Beldarrain
M
M
Servicio y Cátedra de Neurología, Hospital de Cruces, Facultad de Medicina y Odontología, Universidad del País Vasco-Euskal Herriko Unibersitatea.
Pérez-Bas
M
M
Rosell
M
M
Tánago
J
J
Forcadas
I
I
Zarranz
J J
JJ
D001933:Brain Stem; D002531:Cerebellum; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications*; D007970:Leukopenia / Q000150:complications* / Q000209:etiology; D008875:Middle Aged
Leucoencefalopatía multifocal progresiva asociada a leucopenia de origen desconocido (yatrógena?).