Biological true and false serological tests for syphilis: their relationship with anticardiolipin antibodies.
Anticardiolipin antibodies (ACA) were determined by an ELISA assay in 142 VDRL-positive patients who were classified in two groups: group I consisted of 77 patients with syphilis and group II of 65 patients with biological false-positive reaction in the standard test for syphilis. In group I 10% had ACA versus 52% in group II (p less than 0.0001). Isotype distribution in group II showed a predominance of IgG. These results suggest that antiphospholipid antibodies in VDRL and ACA tests have different specificities.
Bernard
C
C
Hemostasis Unit, University Hospital, Geneva, Switzerland.
de Moerloose
P
P
Tremblet
C
C
Reber
G
G
Didierjean
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013587:Syphilis / Q000175:diagnosis / Q000276:immunology*; D013588:Syphilis Serodiagnosis
D000888:Antibodies, Anti-Idiotypic; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M