title: Reduction of interleukin-2-receptor expression on retroplacental blood lymphocytes in human pregnancy.
abstract: Retroplacental blood lymphocytes (RPL) in human pregnancy were studied for proliferative response induced by recombinant interleukin-2 (rIL-2) and anti-Tac positive cells before and after PHA stimulation for 24 hr and compared with peripheral blood lymphocytes (PBL) of the same donor. Proliferation of RPL induced by IL-2 was significantly lower than that of PBL in all of six cases. In addition, flow cytometry analysis of IL-2 receptors (IL-2R) revealed that IL-2R expression of RPL after stimulation with PHA for 24 hr was significantly less than that of PBL in three of four cases and that RPL showed significantly fewer IL-2R than PBL even at resting state in one case. These results suggest that RPL seem likely to be composed of reduced numbers of lymphocytes bearing IL-2R of non-Tac protein and to have impaired capacity for the acquisition of high-affinity receptors for IL-2.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Kanzaki
authors.forename: M
authors.initials: M
authors.lastname: Kariya
authors.forename: N
authors.initials: N
authors.lastname: Emi
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: A
authors.initials: A
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Kasakura
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology; D008213:Lymphocyte Activation / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology*; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2