title: Development of 5q- myelodysplasia in a patient with sarcoidosis.
abstract: Sarcoidosis has been observed in association with numerous blood dyscrasias including lymphoma, leukemia, and multiple myeloma. This report describes a patient with sarcoidosis and a refractory anemia whose bone marrow karyotype showed deletion of the long arm of chromosome 5, consistent with a myelodysplastic syndrome. Concurrent sarcoidosis and myelodysplasia may relate to the continued availability of cytokines as a consequence of repeated macrophage, T-cell, and B-cell interactions, with evolution to the 5q- abnormality. This association may merit specific attention in the future approach to the diagnostic evaluation in certain patients with sarcoidosis.
authors.affiliation: Department of Medicine, Medical College of Pennsylvania, Philadelphia.
authors.forename: A R
authors.initials: AR
authors.lastname: Tunkel
authors.forename: K J
authors.initials: KJ
authors.lastname: Sebastianelli
authors.forename: N
authors.initials: N
authors.lastname: Pandit
authors.forename: J I
authors.initials: JI
authors.lastname: Brody
mesh_terms: D000368:Aged; D000753:Anemia, Refractory / Q000150:complications*; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics; D012507:Sarcoidosis / Q000150:complications* / Q000235:genetics