title: Seizures following the use of proparacaine hydrochloride eye drops.
abstract: A 28-year-old woman presented to the emergency department for treatment of a corneal abrasion. Shortly after inserting two drops of proparacaine hydrochloride eye drops into her conjunctival sac, she experienced a tonic-clonic seizure. The absorption, systemic effects, and side effects of topical ophthalmological preparations are discussed.
authors.affiliation: Department of Internal Medicine, Northwestern University Medical School, Chicago, Illinois.
authors.forename: R K
authors.initials: RK
authors.lastname: Cydulka
authors.forename: S
authors.initials: S
authors.lastname: Betzelos
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects; D065306:Corneal Injuries; D005260:Female; D006801:Humans; D009883:Ophthalmic Solutions; D011430:Propoxycaine / Q000009:adverse effects* / Q000493:pharmacokinetics; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000779:Anesthetics, Local; D009883:Ophthalmic Solutions; C005717:proxymetacaine; D011430:Propoxycaine