Immediate post-operative urokinase infusion: extending the limits of limb salvage surgery.
We report the case of a 74-year-old woman with multi-level arterial occlusive disease and severe ischemia of the right lower extremity who underwent a re-operative femoro-femoral and a right femoro-popliteal bypass graft. Her right foot remained non-viable post-operatively despite patent grafts. She then underwent a 12-hour infusion of urokinase through a percutaneously placed popliteal artery catheter during that first post-operative day, with salvage of the right leg.
Perler
B A
BA
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Osterman
F A
FA
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000601:surgery; D001166:Arteriovenous Shunt, Surgical; D001807:Blood Vessel Prosthesis; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D011182:Postoperative Care; D012086:Reoperation; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D014568:Urokinase-Type Plasminogen Activator