The effect of centrally administered naloxone on deprivation and drug-induced feeding.
In the present study we evaluated the effect of intracerebroventricular (ICV) administration of naloxone on feeding induced by food deprivation, norepinephrine (NE), muscimol and neuropeptide Y (NPY). Naloxone (200, 100 and 50 micrograms ICV) decreased deprivation-induced feeding. In contrast, only the 200 micrograms dose of naloxone decreased NE-induced feeding and the 200 and 100 micrograms doses decreased muscimol-induced feeding. Eating stimulated by central administration of NPY was potently decreased by doses of naloxone ranging from 10-200 micrograms.
Levine
A S
AS
Neuroendocrine Research Laboratory, VA Medical Center, Minneapolis, MN 55417.
Grace
M
M
Billington
C J
CJ
D000818:Animals; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation; D007276:Injections, Intraventricular; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y; D009118:Muscimol; D009270:Naloxone; D009638:Norepinephrine