title: Malformational complex in an infant with intrauterine influenza viral infection.
abstract: An infant with complex malformations of the central nervous system is described. The abnormalities included ependymal damage, aqueduct forking, hydrocephalus, and neuronal heterotopias; agenesis of the cerebellum, pontine, and inferior olivary neutrons; agenesis of the optic and olfactory systems and corpus callosum; and a highly unusual course of the corticospinal fibers in the spinal cord. Immunohistochemical test results showed the presence of influenza virus antigens in the brain. Possible pathogenetic mechanisms are presented.
authors.affiliation: Department of Pathology, University Hospitals of Cleveland, Ohio.
authors.forename: P T
authors.initials: PT
authors.lastname: Conover
authors.forename: U
authors.initials: U
authors.lastname: Roessmann
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology*; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007251:Influenza, Human / Q000150:complications* / Q000151:congenital / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology
chemical_list: D000956:Antigens, Viral