title: A prospective evaluation of OC125 and magnetic resonance imaging in patients with ovarian carcinoma.
abstract: Eighteen patients with suspected primary or recurrent ovarian carcinoma have been investigated in each case by the assay of serum levels of the antigen CA125, immunoscintigraphy using 131I-OC125 antibody and magnetic resonance imaging using a 0.15 Tesla system. The final diagnosis was confirmed by laparotomy or laparoscopy. Serum levels of CA125 ranged between 5 and 780 units/ml (normal range less than 35). Antibody images and MRI were truly positive in 11 patients, 2 of whom were subsequently found to have bowel tumours. MRI showed greater detail of smaller lesions whilst immunoscintigraphy was more suited to the detection of distant metastases. In 7 patients the antibody images were positive whilst the serum marker levels were normal. This pilot study provides a preliminary comparison of the more recent techniques currently being evaluated for the detection of ovarian carcinoma.
authors.affiliation: Department of Medical Physics, University Hospital, Nottingham, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Perkins
authors.forename: M C
authors.initials: MC
authors.lastname: Powell
authors.forename: M L
authors.initials: ML
authors.lastname: Wastie
authors.forename: I V
authors.initials: IV
authors.lastname: Scott
authors.forename: A
authors.initials: A
authors.lastname: Hitchcock
authors.forename: B S
authors.initials: BS
authors.lastname: Worthington
authors.forename: E M
authors.initials: EM
authors.lastname: Symonds
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes