title: Bone and joint manifestations of sickle cell anaemia.
abstract: We investigated 57 patients with sickle cell anaemia (HbSS) and bone and joint changes. Osteonecrosis simulating a wide range of conditions was a common radiological feature, and osteomyelitis occurred in 61% of cases. Salmonella species were the commonest causative organisms, occurring in 71% of patients with osteomyelitis, although salmonella septic arthritis occurred in only two. The distinction between vaso-occlusive bone crisis and acute osteomyelitis was often difficult since the classical clinical and radiological features and laboratory findings also occurred in bone infarction, a common feature of the disease.
authors.affiliation: Dammam Central Hospital, Saudi Arabia.
authors.forename: O M
authors.initials: OM
authors.lastname: Bennett
authors.forename: S S
authors.initials: SS
authors.lastname: Namnyak
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001170:Arthritis, Infectious / Q000209:etiology; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000209:etiology; D010020:Osteonecrosis / Q000209:etiology; D011859:Radiography; D012480:Salmonella Infections