Role of interaction of the tanycytes of the third ventricle of the brain with the vascular bed endothelium in enzymatic activation of the parkinsonism-inducing proneurotoxin MPTP in rat brain.
The authors describe the localization of monoaminooxidases oxidizing the protoxin MPTP to the active neurotoxic MPP+ ion, which induces parkinsonism by destroying the dopaminergic neurons of the nigrostriatum. Apart from some types of magnocellular neurons of the hypothalamus, enzymatic activity is localized in the endothelium of segments of the circumventricular vascular bed communicating with the enzymatically equally positive processes of the tanycytes of the third brain ventricle. The findings are briefly discussed from the aspect of the pathogenesis of experimental parkinsonism.
Horský
J
J
J.E. Purkynĕ Medical Academy, Hradec Králové, Czechoslovakia.
Krs
O
O
Bielavský
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002552:Cerebral Ventricles / Q000098:blood supply / Q000166:cytology / Q000201:enzymology*; D004730:Endothelium, Vascular / Q000201:enzymology*; D005260:Female; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D051381:Rats
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine