title: [The dynamics of perioperative coagulopathies in lung cancer patients depending on the type of anesthesia and on the change in the level of endogenous intoxication].
abstract: Serum medium-size molecules (MSM) and blood coagulation parameters have been studied before and after surgery in 60 patients randomized into 2 groups. Patients in group I were subjected to multicomponent endotracheal anesthesia with neuroleptanalgesia and cardiopulmonary bypass and to postoperative analgesia with non-narcotic and narcotic analgesics. Patients in group II were additionally subjected to epidural anesthesia into upper chest segments with trimecaine + adrenaline and low morphine doses. Prior to surgery many patients showed signs of the first-degree disseminated intravascular coagulation syndrome. Parallel changes in the postoperative clinical course, pathological shifts in coagulograms and changes in MSM levels (which were maximum on the fourth day postoperatively in both groups) have been established. Patients in group II were found to have a more favourable coagulation profile.
authors.forename: L F
authors.initials: LF
authors.lastname: Kosonogov
authors.forename: E M
authors.initials: EM
authors.lastname: Shamaev
authors.forename: V S
authors.initials: VS
authors.lastname: Fofonova
authors.forename: V F
authors.initials: VF
authors.lastname: Romanovskaia
mesh_terms: D000767:Anesthesia, Epidural / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000601:surgery; D006801:Humans; D007431:Intraoperative Complications / Q000097:blood* / Q000601:surgery; D008175:Lung Neoplasms / Q000097:blood* / Q000601:surgery; D008297:Male; D008970:Molecular Weight; D009458:Neuroleptanalgesia; D009842:Oligopeptides / Q000097:blood; D011013:Pneumonectomy; D011183:Postoperative Complications / Q000097:blood*; D011229:Preanesthetic Medication; D011897:Random Allocation
chemical_list: D009842:Oligopeptides
vernacular_title: Dinamika perioperatsionnykh koagulopatiĭ u bol'nykh rakom legkogo v zavisimosti ot vida anestezii i izmeneniia urovnia éndogennoĭ intoksikatsii.