Aneurysm, arachnoiditis and intrathecal Au (gold).
This report is a 20-year follow-up of 14 patients treated with external beam craniospinal irradiation and intrathecal gold (10-45 mCi) for medulloblastoma. Six of the patients died within 2 years of treatment from persistent disease. No patients are alive without complications. Six of eight surviving patients developed arachnoiditis and cauda equina syndrome within 5 to 10 years of treatment. Seven of eight survivors developed aneurysms and/or cerebrovascular accidents 9 to 20 years after treatment. Four of the cerebrovascular events were fatal. Intrathecal gold pools in the basal cisterns and cauda equina delivering an extremely inhomogeneous dose throughout the neuroaxis. Its use is discouraged.
Pence
D M
DM
Department of Therapeutic Radiology, Radiation Oncology, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Kim
T H
TH
Levitt
S H
SH
D000293:Adolescent; D000328:Adult; D001100:Arachnoiditis / Q000209:etiology*; D001918:Brachytherapy / Q000009:adverse effects*; D002528:Cerebellar Neoplasms / Q000532:radiotherapy*; D002543:Cerebral Hemorrhage / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006050:Gold Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007278:Injections, Spinal / Q000009:adverse effects*; D002532:Intracranial Aneurysm / Q000209:etiology*; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*
D006050:Gold Radioisotopes