title: Cystic fibrosis and allergic bronchopulmonary aspergillosis.
abstract: We have prospectively screened our patients with cystic fibrosis for allergic bronchopulmonary aspergillosis. Over a three year period eight patients were identified, an incidence of 5.8%. Patients were clinically well at the time of diagnosis (Shwachman scores 70-90, Chrispin-Norman chest x ray scores 2-15) and they responded rapidly to treatment with oral prednisolone. There has been little deterioration in their respiratory function and nutrition over the study period. We conclude that allergic bronchopulmonary aspergillosis is not uncommon in patients with cystic fibrosis. It is a potential cause of lung damage and prospective screening could lead to earlier detection and treatment.
authors.affiliation: Regional Cystic Fibrosis Unit, St James's University Hospital, Leeds.
authors.forename: E J
authors.initials: EJ
authors.lastname: Simmonds
authors.forename: J M
authors.initials: JM
authors.lastname: Littlewood
authors.forename: E G
authors.initials: EG
authors.lastname: Evans
mesh_terms: D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008168:Lung / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D011239:Prednisolone