title: Effects of human placental S9 and induced rat liver S9 on the mutagenicity of drinking waters processed from humus-rich surface waters.
abstract: The mutagenicity of chlorinated drinking waters processed from humus-rich surface waters has been shown to be very high. The effect of placental S9 on the mutagenicity of drinking waters has not been studied previously. The purpose of this study was to compare the effects of human placental and rat liver microsomal fractions on the mutagenicity of drinking waters processed from humus-rich surface waters. The samples of 34 drinking and two raw waters from 26 localities in Finland were tested for mutagenicity in Ames Salmonella typhimurium tester strain TA100 with and without metabolic activations. Between the drinking water samples, clear differences were recorded in the presence of placental and rat liver S9, suggesting different mutagens in the drinking waters. Rat liver S9 decreased the mutagenicities of drinking water concentrates, but placental S9 increased, decreased, or had no effect. It is not known if placental mutagenicity enhancing system might cause any health hazard to a developing fetus.
authors.affiliation: National Public Health Institute, Department of Environmental Hygiene and Toxicology, Kuopio, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Vartiainen
authors.forename: S
authors.initials: S
authors.lastname: Lampelo
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D010920:Placenta / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014873:Water Pollutants / Q000633:toxicity*; D014881:Water Supply
chemical_list: D009153:Mutagens; D014873:Water Pollutants