title: Neutrophil chemotactic activity of N-terminal peptides from the calpain small subunit.
abstract: On the basis of previous findings that N-acetyl nonapeptide from the human calpain I large subunit has chemotactic activity for neutrophils, a series of peptides with the N-terminal sequence of the calpain small subunit were synthesized and their chemotactic activity was examined. Potent activity was found in N-acetyl tetra, hepta, octa, nona and a larger peptide of 13 residues, although N-acetyl tripeptide showed only weak activity and N-acetyl penta and hexa peptides showed almost no activity. Since the small subunit is identical in calpains I and II, the results indicate that both calpains could be precursor proteins of chemotactic factors for neutrophils.
authors.affiliation: Department of Biochemistry, Nagoya City University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kunimatsu
authors.forename: X J
authors.initials: XJ
authors.lastname: Ma
authors.forename: J
authors.initials: J
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Shioiri
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000595:Amino Acid Sequence; D002154:Calpain; D002630:Chemotactic Factors; D002634:Chemotaxis, Leukocyte; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000502:physiology*; D010446:Peptide Fragments / Q000138:chemical synthesis
chemical_list: D002630:Chemotactic Factors; D010446:Peptide Fragments; D002154:Calpain