Hyperlipidaemia increases albuminuria in hypertensive and normotensive rats.
1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total-cholesterol and a decrease in HDL-cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol-fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.
Cooper
M E
ME
Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia.
Vranes
D A
DA
Panagiotopoulos
S
S
Allen
T J
TJ
Goodall
I
I
Jerums
G
G
D000419:Albuminuria / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000009:adverse effects / Q000097:blood*; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors; D015430:Weight Gain
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL