title: Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta extracts on the central nervous system.
abstract: We report the effects of aqueous extracts of the microalgae Dunaliella tertiolecta Butcher (Chlorophyceae) and Phaeodactylum tricornutum Bohlin (Bacillariophyceae) on oxotremorin-induced cholinergic symptoms, amphetamine-induced hypermotility, pentylenetetrazole-induced convulsions, and Rota-rod test performance. Both extracts significantly reduced rectal temperature, spontaneous motor activity, and time on the Rota-rod and increased the number of mice falling off the rod before 180 s, but neither protected against pentylenetetrazole-induced convulsions or against oxotremorin-induced tremor, salivation, and diarrhoea.
authors.affiliation: Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Galiza, Spain.
authors.forename: M R
authors.initials: MR
authors.lastname: Laguna
authors.forename: R M
authors.initials: RM
authors.lastname: Villar
authors.forename: I
authors.initials: I
authors.lastname: Cadavid
authors.forename: J M
authors.initials: JM
authors.lastname: Calleja
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D016009:Chi-Square Distribution; D056890:Eukaryota / Q000032:analysis*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains