Magnetic resonance imaging in Parkinson's disease.
Magnetic resonance imaging was utilized to examine changes in the pars compacta associated with Parkinson's disease. We found a reduction in average width of the pars compacta in advanced- but not early-stage patients. Conversely, a significant difference in width (right minus left) was observed in early- but not late-stage patients. Width asymmetry may be a sensitive magnetic resonance imaging indicator for the early detection of Parkinson's disease when there is a predominance of unilateral clinical symptoms.
Huber
S J
SJ
Department of Neurology, Ohio State University College of Medicine, Columbus.
Chakeres
D W
DW
Paulson
G W
GW
Khanna
R
R
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*