Determination of plasma nefopam by liquid chromatography and electrochemical detection.
A liquid chromatographic method for the determination of plasma nefopam is presented. A combination of liquid- and solid-phase extraction and electrochemical detection gave clean extracts and, hence, a low limit of detection. Calibration curves were linear over at least two orders of magnitude (1-100 ng/ml) making the method suitable for pharmacokinetic studies.
Burton
L C
LC
Department of Pharmacology and Therapeutics, London Hospital Medical College, U.K.
Loftus
N J
NJ
Vere
D W
DW
Whelpton
R
R
D002853:Chromatography, Liquid / Q000379:methods*; D004563:Electrochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009340:Nefopam / Q000097:blood*; D010079:Oxazocines / Q000097:blood*; D010087:Oxides / Q000378:metabolism
D010079:Oxazocines; D010087:Oxides; D009340:Nefopam