title: Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract.
abstract: Amino acid analysis showed that solvent extracts of Cajanus cajan L. Millsp. (Fabaceae) seeds (white species) contain, as free amino acid, as much as 26.3% phenylalanine. Antisickling experiments based on the estimated amount of free phenylalanine in the methanol (water-soluble) extract of the seeds showed that the presence of this amino acid alone could account for about 70% of the antisickling potency of Cajanus cajan seed extract.
authors.affiliation: Department of Biochemistry, University of Port Harcourt, Nigeria.
authors.forename: G I
authors.initials: GI
authors.lastname: Ekeke
authors.forename: F O
authors.initials: FO
authors.lastname: Shode
mesh_terms: D000293:Adolescent; D000596:Amino Acids / Q000032:analysis; D000986:Antisickling Agents / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D010649:Phenylalanine / Q000302:isolation & purification / Q000494:pharmacology*; D010944:Plants / Q000032:analysis*; D012639:Seeds / Q000032:analysis
chemical_list: D000596:Amino Acids; D000986:Antisickling Agents; D010649:Phenylalanine