title: Fatty acid composition of milk from genetically normotensive and hypertensive rats.
abstract: To assess milk fatty acid composition in genetically normotensive (Wistar Kyoto, WKY) and spontaneously hypertensive (SH) rats, WKY and SH dams (n = 10/strain) were milked under halothane anesthesia on d 5, 13 and 21 postpartum. Milk samples of 0.5-1.0 mL were then analyzed by gas-liquid chromatography. Additional WKY and SH dams (n = 2/strain) were milked on d 5 and 21 postpartum for assessment of total milk fat. In both WKY and SH strains, the amount of 8:0 and 10:0 fatty acids increased from d 5 to 21 (p less than 0.001), whereas the quantity of 18:3(n-6), 20:3(n-9), 20:3(n-6), 22:4(n-6), 22:5(n-3) and 22:6(n-3) fatty acids declined over the same period (p less than 0.001). Milk from SH rats had higher levels of 10:0 and 20:4(n-6) fatty acids on all sampling days than did milk from WKY rats (p less than 0.001), and milk from SH rats had lower levels of 16:1(n-7), 18:1(n-9) and 18:2(n-6) fatty acids on d 13 and 21 (p less than 0.001). There were no differences in milk fat content between strains. These data suggest that genetically hypertensive rat pups obtain significantly greater amounts of 20:4(n-6) and significantly lower amounts of 18:2(n-6) fatty acids from maternal milk than do their normotensive counterparts.
authors.affiliation: Department of Health Studies, University of Waterloo, Ontario, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Mills
authors.forename: R P
authors.initials: RP
authors.lastname: Ward
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002849:Chromatography, Gas; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005260:Female; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D008297:Male; D008892:Milk / Q000032:analysis*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated