Effect of BN 52021, a platelet activating factor antagonist, on dithranol-induced inflammation.
The effect of BN 52021, a selective platelet activating factor (PAF) antagonist was studied on dithranol-induced irritant dermatitis. Pretreatment of the skin with 0.45% BN 52021 ointment significantly suppressed the decrease in capillary resistance, rise in skin temperature and increase in skin-fold thickness produced by dithranol.
Kemény
L
L
Department of Dermatology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Csató
M
M
Braquet
P
P
Dobozy
A
A
D000328:Adult; D000875:Anthralin / Q000009:adverse effects*; D002200:Capillary Resistance / Q000187:drug effects; D003877:Dermatitis, Contact / Q000517:prevention & control*; D004224:Diterpenes; D005260:Female; D046934:Ginkgolides; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D012867:Skin / Q000187:drug effects*; D012881:Skin Temperature / Q000187:drug effects; D012885:Skinfold Thickness
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B; D000875:Anthralin