[Role of the cellular Na+/H+ exchange and glycolysis inhibition by the antiviral action].
Remantadine has been shown to induce a decrease in acidification rate of incubation medium by chick embryo fibroblasts, caused both by Na+/H+ exchange and diffusion of lactic acid, the final product of glycolysis. The degree of acidification rate decrease grew with increasing concentration and time of cell incubation with preparation. Possible implementation of the inhibitory effect of remantadine on acid-dependent process of influenza virus uncoating by decreasing cellular Na+/H+ exchange and glycolysis is discussed.
Kirillov
V A
VA
Goreva
L N
LN
Votiakov
V I
VI
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003470:Culture Media; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D007773:Lactates / Q000378:metabolism; D012299:Rimantadine / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*
D003470:Culture Media; D007773:Lactates; D012299:Rimantadine; D012964:Sodium; D000218:Adamantane
Rol' ingibirovaniia kletochnogo Na+/H+-obmena i glikoliza v antivirusnom deĭstvii.