Urinary excretion of cyclohexanediol, a metabolite of the solvent cyclohexanone, by infants in a special care unit.
Using gas chromatography-mass spectrometry, we investigated the urinary excretion of organic acids of 278 newborn babies in a special care unit to obtain reference data and monitor metabolism. In 101 of 584 urine samples analyzed, we found isomers of cyclohexanediol. trans-1,2-Cyclohexanediol was always most abundant, with small amounts of 1,3- and 1,4-cyclohexanediol and, sometimes, traces of cis-1,2-cyclohexanediol. Glucuronide conjugates were not detected. The probable source was the solvent cyclohexanone, which was found as a contaminant of intravenous dextrose and the parenteral feeding solution, and was also leached into the infusion fluids from the administration set. We recovered 0.89 mg (range 0.74-0.98 mg, n = 5) of cyclohexanone from 150 mL of dextrose pumped through the infusion apparatus over 24 h, the normal rate for a 1-kg premature baby. Although this is well below toxic doses reported for mature animals, more data are needed for the newborn, particularly preterm infants who have a decreased capacity for glucuronide conjugation.
Mills
G A
GA
Clinical Biochemistry, University of Southampton, U.K.
Walker
V
V
D003510:Cyclohexanes / Q000378:metabolism*; D003511:Cyclohexanols / Q000652:urine*; D003512:Cyclohexanones / Q000378:metabolism*; D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000652:urine*; D007234:Infant, Premature / Q000652:urine*; D007363:Intensive Care Units, Neonatal; D015931:Intensive Care, Neonatal
D003510:Cyclohexanes; D003511:Cyclohexanols; D003512:Cyclohexanones; C007192:cyclohexane-1,3-diol; C064620:1,4-cyclohexanediol; C036468:cyclohexanone; C064619:1,2-cyclohexanediol