[Effectiveness of antitubercular chemotherapy combined with corticosteroids and immunomodulators].
One hundred forty eight patients with common forms of pulmonary tuberculosis in an outbreak phase and the presence of secondary immunodeficiency were observed. Caverns were found in 80.4% and bacterial excretion, in 87.16% of the cases. Group 1 (71 persons) received chemotherapeutic drugs only; group 2 (21 persons), chemotherapeutic drugs and T-activin; group 3 (33 persons), chemotherapeutic drugs and corticosteroids; and group 4 (23 persons), chemotherapeutic drugs, corticosteroids and T-activin. The bacterial excretion in all the groups was found to be the same. The regression of infiltrative changes in the lungs by the 6-th month of treatment was more significantly registered in the groups of patients on a regimen containing chemotherapeutic drugs, corticosteroids and T-activin. Cavern closure rate appeared to be the lowest in subjects receiving chemotherapeutic drugs and corticosteroids; the addition of T-activin increases the cavern closure index. The combination of chemotherapeutic drugs, corticosteroids and T-activin promotes the normalization of the cellular immunity and increases the efficacy of pulmonary tuberculosis treatment.
Khomenko
I S
IS
Chukanov
V I
VI
Gergert
V Ia
VIa
Utkin
V V
VV
D000276:Adjuvants, Immunologic; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D010455:Peptides / Q000008:administration & dosage*; D011239:Prednisolone / Q000008:administration & dosage*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013949:Thymus Extracts / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D011239:Prednisolone
Effektivnost' protivotuberkuleznoĭ khimioterapii v sochetanii s kortikosteroidami i immunomoduliatorami.