title: [Significance of the determination of estrogen and progesterone receptors in trophoblast diseases].
abstract: Binding capacity (Bmax) and affinity (Kd) of cytoplasmatic estradiol and progesteron receptors were determined in trophoblastic tissue and in decidual endometrium by the authors. Results in normal and pathological endometrium and in mature placenta tissue were compared. Both estrogen and progesteron receptors were proved to exist in the decidual endometrium nearest to the molar tissue. Their binding parameters are similar to those in normal endometrium. No progesterone receptors were found in the molar tissue. Binding capacity of estrogens were found to be similar to that of the normal mature placenta. The lack of progesterone receptors might be an etiological factor in the pathogenesis of trophoblast diseases.
authors.affiliation: Institut für Arztliche Fortbildung, Klinik für Geburtshilfe und Gynäkologie, Budapest.
authors.forename: I
authors.initials: I
authors.lastname: Cseh
authors.forename: J
authors.initials: J
authors.lastname: Szepesi
authors.forename: S
authors.initials: S
authors.lastname: Walentin
authors.forename: T
authors.initials: T
authors.lastname: Szabó
authors.forename: S
authors.initials: S
authors.lastname: Dravucz
authors.forename: J
authors.initials: J
authors.lastname: Szalay
authors.forename: I
authors.initials: I
authors.lastname: Gati
mesh_terms: D000022:Abortion, Spontaneous / Q000473:pathology; D000328:Adult; D003656:Decidua / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology*; D007231:Infant, Newborn; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D014594:Uterine Neoplasms / Q000473:pathology*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
vernacular_title: Die Bedeutung der Bestimmung von Estrogen- und Progesteronrezeptoren bei Trophoblasterkrankungen.