The in-vitro activity of cefpodoxime: a comparison with other oral cephalosporins.
The in-vitro activity of cefpodoxime was studied in 529 clinical isolates and compared with the activity of other oral beta-lactams. Amongst the Enterobacteriaceae cefpodoxime was very active (MIC90 less than or equal to 1 mg/l--other than genera commonly possessing chromosomal beta-lactamases). Against these strains cefpodoxime was comparable in activity to cefixime and about eight-fold more active than cefuroxime and 8-16-fold more active than cefaclor and cephalexin. Staphylococcus aureus strains were moderately susceptible (MIC90 4 mg/l) to cefpodoxime in comparison with cefixime (16 mg/l). The respiratory pathogens, Haemophilus influenzae, Streptococcus pneumoniae and Branhamella catarrhalis were susceptible to less than or equal to 0.5 mg/l cefpodoxime. An increase in inoculum from 10(4) to 10(6) cfu had little effect upon activity. Studies in beta-lactamase hydrolysis of cefpodoxime showed it to be stable to TEM-1, SHV-1 and BRO-1 enzymes but with high affinity for the P99 enzyme. The primary target of cefpodoxime is PBP3 (I50 1 mg/l) in Escherichia coli K12. The protein binding of the agent to human serum was 14.3-18.3% at 1 and 5 mg/l respectively.
Wise
R
R
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
Andrews
J M
JM
Ashby
J P
JP
Thornber
D
D
D000284:Administration, Oral; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D006602:Hexosyltransferases; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism; D010458:Peptidyl Transferases; D001618:beta-Lactamases / Q000378:metabolism; D000097623:Cefpodoxime
D001426:Bacterial Proteins; D002352:Carrier Proteins; D015296:Ceftizoxime; D002511:Cephalosporins; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D010458:Peptidyl Transferases; D001618:beta-Lactamases; D000097623:Cefpodoxime