title: Measurement of regional cerebral blood flow in cat brain using intracarotid 2H2O and 2H NMR imaging.
abstract: Cerebral blood flow (CBF) was measured in cat brain in vivo at 2.7 T using 2H NMR to monitor the washout of deuterated saline injected into both carotid arteries via the lingual arteries. In anesthetized cats, global CBF varied directly with PaCO2 over a range of 20-50 mm Hg, and the corresponding global CBF values ranged from 25 to 125 ml.100 g-1.min-1. Regional CBF was measured in a 1-cm axial section of cat brain using intracarotid deuterated saline and gradient-echo 2H NMR imaging. Blood flow images with a maximum pixel resolution of 0.3 x 0.3 x 1.0 cm were generated from the deuterium signal washout at each pixel. Image derived values for CBF agreed well with other determinations, and decreased significantly with hypocapnia.
authors.affiliation: Department of Biochemistry/Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104.
authors.forename: J A
authors.initials: JA
authors.lastname: Detre
authors.forename: V H
authors.initials: VH
authors.lastname: Subramanian
authors.forename: M D
authors.initials: MD
authors.lastname: Mitchell
authors.forename: D S
authors.initials: DS
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Zaman
authors.forename: J S
authors.initials: JS
authors.lastname: Leigh
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002339:Carotid Arteries; D002415:Cats; D002560:Cerebrovascular Circulation; D003903:Deuterium; D008279:Magnetic Resonance Imaging
chemical_list: D003903:Deuterium