Immunohistochemistry of superoxide dismutase-1 in developing human brain.
The developmental changes in superoxide dismutase (SOD)-1 were studied in brains ranging in age from human fetuses to adults by immunohistochemistry. SOD-positive neurons and glial cells appeared with maturation in each region, and increased progressively with gestational and postnatal age. This phenomenon implies a relationship between SOD-1 gene expression and the anti-oxidant defence mechanism in developing neurons and glia.
Takashima
S
S
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Kuruta
H
H
Mito
T
T
Houdou
S
S
Konomi
H
H
Yao
R
R
Onodera
K
K
D000328:Adult; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D002675:Child, Preschool; D004622:Embryo, Mammalian / Q000201:enzymology*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase