Acetylation of 5-aminosalicylate by hamster colon arylamine N-acetyltransferase.
Recent evidence suggests that 5-aminosalicylate acts as an anti-inflammatory agent by virtue of its ability to act as a free-radical scavenger. The major metabolite, N-acetyl-5-aminosalicylate is not an effective free-radical scavenger. We have demonstrated that an arylamine N-acetyltransferase from hamster colon can directly acetylate 5-aminosalicylate, suggesting that the colon may have the ability to modulate the activity of this agent through metabolic inactivation.
Tucker
M A
MA
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Terre Haute 47809.
Smith
T J
TJ
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000636:Aminosalicylic Acids / Q000378:metabolism*; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D003106:Colon / Q000201:enzymology* / Q000378:metabolism; D006224:Cricetinae; D005260:Female; D008297:Male; D019804:Mesalamine; D008647:Mesocricetus
D000636:Aminosalicylic Acids; D019804:Mesalamine; D000123:Acetyltransferases; D001191:Arylamine N-Acetyltransferase