title: Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury.
abstract: Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.
authors.affiliation: Webb-Waring Lung Institute, Department of Medicine, University of Colorado, Health Sciences Center, Denver 80262.
authors.forename: M L
authors.initials: ML
authors.lastname: Waintrub
authors.forename: L S
authors.initials: LS
authors.lastname: Terada
authors.forename: C J
authors.initials: CJ
authors.lastname: Beehler
authors.forename: B O
authors.initials: BO
authors.lastname: Anderson
authors.forename: J A
authors.initials: JA
authors.lastname: Leff
authors.forename: J E
authors.initials: JE
authors.lastname: Repine
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008171:Lung Diseases / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D010269:Paraquat / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014414:Tungsten / Q000494:pharmacology; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D000418:Albumins; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D010269:Paraquat; D014414:Tungsten