title: [Mycosis fungoides. A review of the clinical picture, treatment and course in 107 patients].
abstract: During the period 1972 till the end of 1987, 107 patients with the diagnosis of mycosis fungoides or cutaneous T-cell lymphoma were examined and treated in the Department of Dermatology, Marselisborg Hospital. This disease belongs to the group of non-Hodgkin T-cell lymphomata. The diagnosis is based on the occurrence of red, scaly plaques in the skin associated with itching or tumours in the skin and, simultaneously, of a pleomorphic infiltrate consisting of CD4-positive T-lymphocytes which show characteristically exocytoses in the epidermis with subsequent formation of Pautrier's microabscesses. The disease may progress with spread to the regional lymph nodes where lymphomata develop. Treatment is initially local with employment of chlormethin ("nitrogen mustard gas") and this treatment can maintain the patients in remission for prolonged periods. In cases with spread to lymph glands or in particularly aggressive forms with tumour formation in the skin, combined chemotherapy is administered (prednisone, cyclophosphamide, etretinate and bleomycin). Thirty-eight of the patients were in stage I in which a clinical suspicion of mycosis fungoides was present but where the histological changes were insufficient to confirm the diagnosis. IVa and ten in stage IVb. The age at the onset of the symptoms was from 59 to 64 years (median values) for the various stages. Stages I and II had approximately 80% five-year survival, while the stages with more extensive spread had approximately 50% survival. The etiology of the disease is unknown but, during recent years, certain evidence has been found suggesting that activation of a retrovirus in the epidermis may be a contributory factor.
authors.affiliation: Marselisborg Hospital, Arhus.
authors.forename: M
authors.initials: M
authors.lastname: Kristensen
authors.forename: D
authors.initials: D
authors.lastname: Illum
authors.forename: H
authors.initials: H
authors.lastname: Søgaard
authors.forename: H
authors.initials: H
authors.lastname: Zachariae
authors.forename: K
authors.initials: K
authors.lastname: Kaltoft
authors.forename: K
authors.initials: K
authors.lastname: Thestrup-Pedersen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*
vernacular_title: Mycosis fungoides. En opgørelse af klinisk billede, behandling og forløb hos 107 patienter.