title: Bone marrow transplantation for chronic myelogenous leukemia. Results of the French Cooperative Group (GEGMO).
abstract: Data on 281 patients with chronic myelogenous leukemia who received bone marrow transplants were analyzed. The median follow-up time was 48 months. One hundred and seventy patients were in 1st chronic phase, 111 were in more advanced disease. The overall actuarial survival was 50% at 5 years. In multivariate analyses, the probability of relapse was correlated with the phase of the disease, the method of total body irradiation, the T cell depletion of the marrow and the occurrence of a chronic GVHD. The probability of disease free survival was significantly better for the patients who received a non T cell depleted marrow than for recipients of T cell depleted marrow. Bone marrow transplantion in first chronic phase with an HLA identical non T cell depleted marrow offers the better chance of prolonged leukemia free survival.
authors.affiliation: Bone Marrow Transplant Unit, Service d'Hématologie, Hôpital Saint-Louis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Devergie
authors.forename: J
authors.initials: J
authors.lastname: Reiffers
authors.forename: J P
authors.initials: JP
authors.lastname: Vernant
authors.forename: J Y
authors.initials: JY
authors.lastname: Cahn
authors.forename: D
authors.initials: D
authors.lastname: Guyotat
authors.forename: D
authors.initials: D
authors.lastname: Maraninchi
authors.forename: B
authors.initials: B
authors.lastname: Rio
authors.forename: M
authors.initials: M
authors.lastname: Michallet
authors.forename: J P
authors.initials: JP
authors.lastname: Jouet
authors.forename: N
authors.initials: N
authors.lastname: Milpied
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000601:surgery*; D011658:Pulmonary Fibrosis / Q000453:epidemiology / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate