Sulphamethoxazole acetylation in fast and slow acetylators.
Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
Bozkurt
A
A
Department of Pharmacology, University of Hacettepe, Ankara, Turkey.
Basci
N E
NE
Isimer
A
A
Tuncer
M
M
Erdal
R
R
Kayaalp
S O
SO
D000107:Acetylation; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism; D013420:Sulfamethoxazole / Q000097:blood / Q000378:metabolism* / Q000652:urine
D013418:Sulfamethazine; D013420:Sulfamethoxazole