[Blood glutathione in idiopathic nephrotic syndrome of childhood].
We studied blood glutathione in children with idiopathic nephrotic syndrome (INS). Plasma glutathione concentrations were significantly (p less than 0.02) lower in INS patients at relapses (0.37 +/- 0.29 microgram/ml, n = 21) than those in controls (0.62 +/- 0.36 microgram/ml, n = 22). As compared with patients with chronic glomerulonephritis (316.4 +/- 128.3, n = 8), the INS patients had lower blood glutathione concentrations (208.3 +/- 46.1 micrograms/ml, n = 6), although the difference was not statistically significant (p less than 0.10). The glutathione, mixed in the solutions containing plasma proteins or bovine serum albumin, showed sequential reductions of the concentration with time. There was no significant difference between the blood glutathione concentrations in the rats given glutathione containing water for 7 days and in those given distilled water. An inverse correlation was noted between blood glutathione and plasma cholesterol levels in the rats. From these results it may be concluded that INS patients have a decreased blood glutathione level, although the cause is unknown.
Asami
T
T
Department of Pediatrics, School of Medicine, Niigata University, Japan.
Toyabe
S
S
Hashimoto
N
N
Sakai
K
K
D000293:Adolescent; D000818:Animals; D002648:Child; D002784:Cholesterol / Q000097:blood; D005978:Glutathione / Q000097:blood*; D006801:Humans; D009404:Nephrotic Syndrome / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D002784:Cholesterol; D005978:Glutathione