title: Impact of L-phenylalanine supplementation on the performance of three-week-old broilers fed diets containing ochratoxin A. 1. Effects on body weight, feed conversion, relative organ weight, and mortality.
abstract: An experiment with a completely randomized 2-by-3 factorial design was used to study the effects of ochratoxin A (OA; 0 and 4 mg of OA per kg) and supplemental L-phenylalanine (Phe; .0%, .8%, and 2.4% of Phe) in the diets of 3-wk-old broilers. Diets based on ground yellow corn and dehulled soybean meal were fed from Day 1 to 3 wk of age. A total of 240 male Hubbard-by-Hubbard broilers were randomly placed in battery brooders with 10 birds per pen. Each treatment was replicated 4 times. The parameters measured included mortality, BW, feed conversion, and relative organ weight. Broilers receiving OA weighed less and had poorer feed conversions than birds not receiving OA. For broilers receiving OA, the relative weights (grams of organ weight per 100 g of BW) of the liver, proventriculus, gizzard, and heart increased, while the relative weight of the bursa decreased. Supplemental Phe decreased the relative weight of the liver and increased the relative weight of the gizzard and heart. The regression slopes for Phe at 4 mg of OA per kg of diet were significantly different from 0 for BW, the relative weights of the kidney, spleen, and pancreas and approached significance for mortality (P = .065). In the absence of supplemental Phe, 42.5% of the birds died during the study when the dose level was 4 mg of OA per kg of diet. However, when Phe was supplemented at .8 and 2.4%, only 12.5 and 15.0% of the birds died, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Poultry Science, Texas A&M University, College Station 77843.
authors.forename: R M
authors.initials: RM
authors.lastname: Gibson
authors.forename: C A
authors.initials: CA
authors.lastname: Bailey
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: W E
authors.initials: WE
authors.lastname: Huff
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002645:Chickens / Q000254:growth & development*; D004347:Drug Interactions; D008297:Male; D009793:Ochratoxins / Q000506:poisoning*; D009929:Organ Size / Q000187:drug effects; D010649:Phenylalanine / Q000494:pharmacology*; D011897:Random Allocation; D012044:Regression Analysis
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A; D010649:Phenylalanine