The effect of topical interferon alpha 2b on actinic keratoses.
As a result of the known effects of intralesional interferon alfa 2b (Intron A) on actinic keratoses, we have now examined the effects of topical interferon alfa 2b gel on actinic keratoses. Twenty-four subjects each treated three actinic keratoses with either interferon gel 30 million IU/gm or a placebo preparation applied topically 4 times a day for 4 weeks. Although more lesions treated with the active interferon showed clinical improvement, this difference was not statistically significant.
Edwards
L
L
Department of Internal Medicine (Dermatology), University of Arizona Medical Center, Tucson.
Levine
N
N
Smiles
K A
KA
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005782:Gels; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000627:therapeutic use; D007642:Keratosis / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D011994:Recombinant Proteins; D014466:Ultraviolet Rays / Q000009:adverse effects*
D005782:Gels; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins