Effect of choline administration on the release of acetylcholine from the striatum as determined by microdialysis in awake rats.
The release of acetylcholine from the striatum was recorded by an on-line microdialysis method during intraperitoneal administration of high doses of choline (1 mmol/kg). The effect of choline administration was also studied in rats in which the striatal release of acetylcholine was stimulated by atropine infusion. The results did not support the idea that the release of acetylcholine in the striatum is under the control of precursor availability.
Westerink
B H
BH
University Centre for Pharmacy, Department of Medicinal Chemistry, Groningen, The Netherlands.
de Boer
P
P
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002794:Choline / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004563:Electrochemistry; D008297:Male; D051381:Rats
D001285:Atropine; D002794:Choline; D000109:Acetylcholine