title: Neuropeptide diversity in Ascaris: an immunocytochemical study.
abstract: An immunocytochemical method was used for localization of various peptide-like substances in the Ascaris nervous system. Out of 45 antipeptide antisera, 12 demonstrated immunoreactivity in different subsets of neurons; these 12 antisera were raised against luteinizing hormone-releasing hormone (LHRH), Aplysia peptide L11 (L11), Aplysia peptide 12B (12B), small cardioactive peptide B (SCPB), neuropeptide Y (NPY), FMRFamide, gastrin-17, cholecystokinin octapeptide (CCK-8), alpha-melanocyte stimulating hormone (alpha MSH), calcitonin gene related peptide (CGRP), corticotropin releasing factor (CRF), and vasoactive intestinal peptide (VIP). Several peptide-like substances were colocalized to the same neuron. Our results suggest that Ascaris, like other organisms, contains multiple peptidergic systems.
authors.affiliation: Department of Zoology, University of Wisconsin-Madison 53706.
authors.forename: P
authors.initials: P
authors.lastname: Sithigorngul
authors.forename: A O
authors.initials: AO
authors.lastname: Stretton
authors.forename: C
authors.initials: C
authors.lastname: Cowden
mesh_terms: D000818:Animals; D001200:Ascaris / Q000378:metabolism*; D019835:FMRFamide; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009420:Nervous System / Q000166:cytology / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D019835:FMRFamide