[The effect of muscle relaxants on the function of the vestibulo-ocular reflex arc].
Baclofen affects in experiments the reactivity of the vestibuloocular reflex by influencing the time constant of the vestibular nystagmus. The authors compare in three healthy volunteers the reactivity of the vestibular apparatus after administration of Baclofen and a new muscle-relaxant drug tizanidine. The authors evaluate basic parameters of the vestibular and optokinetic nystagmus (gain and time constant), discuss the problem of GABAergic (Baclofen) and monoaminergic (tizanide) receptors kin the area of the vestibular apparatus. As regards the effect on the reactivity of the vestibular system, tizanidine does not affect immediately the response of the vestibuloocular reflex but interferes with processes ensured by the central neuronal integrator.
Jerábek
J
J
Neurologická klinika fakulty dĕtského lékarství KU, Praha.
Krejcová
H
H
Cerný
R
R
Vyskocilová
M
M
D000328:Adult; D001418:Baclofen / Q000494:pharmacology*; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects*
D009125:Muscle Relaxants, Central; C023754:tizanidine; D001418:Baclofen; D003000:Clonidine
Vliv myorelaxancií na funkce vestibulokulárního reflexního okruhu.