Propylthiouracil-induced hepatic failure and encephalopathy in a child.
Propylthiouracil (PTU) is the most common antithyroid medication utilized in children for the treatment of hyperthyroidism. An adverse effect of PTU reported infrequently is hepatic injury. The child described here is the fifth reported case of severe hepatic injury in the pediatric age group and documents that clinical or biochemical evidence of hepatic injury requires immediate discontinuation of PTU.
Kirkland
J L
JL
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D002648:Child; D005094:Exophthalmos / Q000188:drug therapy; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use
D011441:Propylthiouracil