Pharmacological priapism: comparison of trazodone- and papaverine-associated cases.
Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine. Trazodone-related priapism uniformly required surgical procedures and resulted in impotence in two of three cases. In contrast, papaverine-associated priapism was successfully managed by aspiration and all seven patients continued to respond to intracorporal treatment. Iatrogenic priapism is an important complication of therapy with vasoactive drugs.
Bardin
E D
ED
Department of Urology, University of Washington, School of Medicine, Seattle.
Krieger
J N
JN
D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D010208:Papaverine / Q000009:adverse effects* / Q000627:therapeutic use; D011317:Priapism / Q000139:chemically induced* / Q000628:therapy; D014196:Trazodone / Q000009:adverse effects* / Q000627:therapeutic use
D010208:Papaverine; D014196:Trazodone