26,27-Hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) prevents osteoporosis induced by immobilization combined with ovariectomy in the rat.
The effect of 26,27-hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) on experimental osteoporosis in the rat induced by a combination of immobilization and ovariectomy was evaluated. F6-1,25(OH)2D3 increased the femur score and the photo-density. The administration of F6-1,25(OH)2D3 also significantly increased the dry weight, the ash weight and the ash content of the bone. Both F6-1,25(OH)2D3 and 1 alpha(OH)D3 showed a nearly dose-dependent effect and significant inhibition of the decrease of bone mass. Histomorphometry revealed a significant decrease of resorption by the administration of F6-1,25(OH)2D3. Bone formation rate in the F6-1,25(OH)2D3 treated group significantly decreased compared with the vehicle group. In conclusion, the pharmacological effective dose of F6-1,25(OH)2D3 was considered to prevent the osteoporotic decrease of bone mass by suppressing the elevated bone turnover.
Okumura
H
H
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
Yamamuro
T
T
Higuchi
S
S
Harada
M
M
Takamura
T
T
Otomo
S
S
Aihara
H
H
Ikekawa
N
N
Kobayashi
T
T
D000818:Animals; D001846:Bone Development; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D003714:Denervation; D005260:Female; D007103:Immobilization; D009929:Organ Size; D010024:Osteoporosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery; D005466:Fluorocarbons
D002117:Calcitriol; D002118:Calcium; C040488:26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3; D005466:Fluorocarbons