Effect of high calcium diet and nitrendipine on the development of high blood pressure in adrenalectomised spontaneously hypertensive rats treated with aldosterone.
The present investigation was designed to study the effect of high calcium diet and nitrendipine on aldosterone-induced development of high blood pressure in young adrenalectomised spontaneously hypertensive rats (SHR). Animals raised on a control calcium diet (0.5% Ca) or high calcium diet (2.5% Ca) were adrenalectomised aged 5-6 weeks and treated with either aldosterone (1 microgram/day subcutaneously) in propylene glycol or aldosterone (1 microgram/day) plus nitrendipine (20 mg/kg/48 hr subcutaneously) in peanut oil. Controls received the aldosterone or nitrendipine vehicle and treatment lasted two weeks. The animals were given 0.9% NaCl ad libitum. Aldosterone caused a significant increase in systolic BP in adrenalectomised SHR fed the control calcium diet when compared with controls and the aldosterone-induced hypertension was blocked by the high calcium diet and nitrendipine (P less than 0.001, n = 4-7). These findings suggest that high dietary calcium has a protective effect against the development of aldosterone-induced hypertension and may enhance that of nitrendipine.
Semafuko
W E
WE
Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906.
Morris
D J
DJ
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002136:Calcium, Dietary / Q000008:administration & dosage*; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D009568:Nitrendipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D002136:Calcium, Dietary; D000450:Aldosterone; D009568:Nitrendipine