Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat.
The aim of this study was to investigate the effects of the 5-HT1A receptor agonists buspirone and ipsapirone (1-10 mg/kg) on plasma adrenaline (A) levels and on glycemia in the conscious rat. The results indicate that buspirone was able, within 5 min, to increase plasma A and glucose levels in a dose-dependent manner. Ipsapirone administration triggered similar patterns, except that the highest dose used (10 mg/kg) promoted a time-dependent increase in plasma A and glucose levels that was maximal at the end of analysis.
Chaouloff
F
F
Laboratoire de Pharmacologie, INSERM U7, CHU Necker-E.M., Paris, France.
Baudrie
V
V
Laude
D
D
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002065:Buspirone / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood / Q000378:metabolism*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D001786:Blood Glucose; D011743:Pyrimidines; D011985:Receptors, Serotonin; C043077:ipsapirone; D002065:Buspirone; D004837:Epinephrine