title: In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles.
abstract: An in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 micrograms of CPA/ml of modified Krebs-Henseleit solution significantly (P less than 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA.
authors.affiliation: USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010.
authors.forename: C D
authors.initials: CD
authors.lastname: Miller
authors.forename: J L
authors.initials: JL
authors.lastname: Richard
authors.forename: F B
authors.initials: FB
authors.lastname: Hembrough
authors.forename: G D
authors.initials: GD
authors.lastname: Osweiler
authors.forename: D F
authors.initials: DF
authors.lastname: Cox
mesh_terms: D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D009126:Muscle Relaxation; D009132:Muscles / Q000187:drug effects*; D009183:Mycotoxins / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D013997:Time Factors; D014422:Turkeys
chemical_list: D007211:Indoles; D009183:Mycotoxins; C000543:cyclopiazonic acid