title: Psychiatric disorders in first degree relatives of children and adolescents with obsessive compulsive disorder.
abstract: One hundred and forty-five first-degree relatives (89 parents [96%] and 56 siblings [98%]) of 46 children and adolescents with severe primary obsessive compulsive disorder (OCD) were personally interviewed with clinical and structured psychiatric interviews. Parent interviews were scored by a rater blind to proband diagnosis. Thirty percent of probands had at least one first-degree relative with OCD: 25% of fathers and 9% of mothers received this diagnosis. Forty-five percent of fathers and 65% of mothers received one or more other psychiatric diagnoses. The increased familial rate of OCD over that expected from a general population, and over that found in parents of conduct disordered patients, is consistent with a genetic factor in OCD. Presenting obsessive compulsive symptoms of probands and their parents were usually dissimilar, arguing against any simple social or cultural transmission.
authors.affiliation: Child Psychiatry Branch, NIMH, Bethesda, MD 20892.
authors.forename: M C
authors.initials: MC
authors.lastname: Lenane
authors.forename: S E
authors.initials: SE
authors.lastname: Swedo
authors.forename: H
authors.initials: H
authors.lastname: Leonard
authors.forename: D L
authors.initials: DL
authors.lastname: Pauls
authors.forename: W
authors.initials: W
authors.lastname: Sceery
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors