[Acute toxicity of flesh oil of Hippophae rhamnoides L. and its protection against experimental hepatic injury].
Protection by flesh oil of Hippophae rhamnoides against hepatotoxicity induced by CCl4 and acetaminophen (AAP) is reported in this paper. It was found that the oil markedly inhibited MDA formation of liver induced by CCl4 and AAP, decreased sGPT levels induced by CCl4 and blocked depletion of GSH damaged liver induced by AAP.LD50 greater than 45.0 g/kg.
Cheng
T
T
Lanzhou Medical College.
Li
T
T
Duan
Z
Z
Cao
Z
Z
Ma
Z
Z
Zhang
P
P
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010938:Plant Oils / Q000494:pharmacology* / Q000633:toxicity
D010938:Plant Oils; D000082:Acetaminophen; D008315:Malondialdehyde; D000410:Alanine Transaminase; D005978:Glutathione