[Experimental study on N-isopropyl-p-iodoamphetamine lung uptake].
Experimental study on N-isopropyl-p-iodoamphetamine lung uptake was performed by means of analyzing microautoradiography obtained by administering 125I-IMP to Wistar male rats. In the normal rat lung at one minute after the intravenous injection of 125I-IMP, there is increased grain density in the interstitial space including the capillary lumen and interalveolar septum, but not in the alveolar space. On the other hand, at 24 hours after the intravenous injection, increased grain density was noted in the alveolar space of the rat lungs which had received a dose of 10 Gy to the unilateral one. But, definite difference was not found in grain density between the irradiated and non-irradiated lung. The results indicate that part of IMP which was taken up by the endothelial cell is capable of passing through capillary-alveolar barrier.
Kosuda
S
S
Department of Radiology, Tokyo Metropolitan Komagome Hospital.
Kawahara
S
S
Ishibashi
A
A
Tamura
K
K
Kubo
A
A
Hashimoto
S
S
D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D020367:Iofetamine; D008168:Lung / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine