An RNA Holliday junction? Structural and dynamic considerations of the bacteriophage T4 gene 60 interruption.
A novel interrupted gene motif has been reported in which a 50-nucleotide insertion into bacteriophage T4 gene 60 appears to be present in the message at the time of translation, yet it is not translated. We present here a dynamic model for how translation may be occurring in the neighborhood of the interruption. The model involves formation of an RNA structure with similarities to a Holliday junction, followed by migration of the branch point in a strand exchange between message and interruption. The advantage of this model over previous ones is that at no time is a new tRNA required to pair with a discontinuous template.
Burke-Agüero
D H
DH
Department of Chemistry, University of California, Berkeley 94720.
Hearst
J E
JE
D000595:Amino Acid Sequence; D001483:Base Sequence; D005814:Genes, Viral; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics*; D013604:T-Phages / Q000235:genetics*
D012367:RNA, Viral