Trimethoprim/sulfamethoxazole-induced renal tubular acidosis.
A child was evaluated for growth failure at the University of California, San Diego. On two occasions the patient had renal bicarbonate wasting, acidosis, and growth failure associated with trimethoprim/sulfamethoxazole (TMP/SMZ) administration. On both occasions, the acidosis resolved and the growth rate normalized following a period without receiving TMP/SMZ. Renal tubular acidosis and growth failure may occur as a result of TMP/SMZ therapy in children.
Murphy
J L
JL
Department of Pediatrics, UCSD School of Medicine.
Griswold
W R
WR
Reznik
V M
VM
Mendoza
S A
SA
D000141:Acidosis, Renal Tubular / Q000139:chemically induced*; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000188:drug therapy; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
D015662:Trimethoprim, Sulfamethoxazole Drug Combination