title: Intrarenal metabolism of angiotensin II.
abstract: This study investigated the intrarenal metabolism of circulating angiotensin II. Mean arterial pressure (MAP), renal hemodynamics, and the arterial, renal venous, and renal tissue concentrations of the angiotensin octapeptide [ANG-(1-8)] were examined following the constant intra-arterial infusion of tritiated angiotensin II [( 3H]ANG-(1-8)] in graded doses of 0.5, 2.0, and 2.5 ng.kg-1.min-1 in five uninephrectomized, anesthetized female dogs. The infusion of [3H]ANG-(1-8) had no significant effect on MAP, glomerular filtration rate, renal blood flow, or urine flow rate. The mean degradation rate of intra-arterially infused [3H]ANG-(1-8) was 72%. The net renal venous plasma concentration of ANG-(1-8) was greater than that predicted from the degradation rate of [3H]ANG-(1-8). High concentrations of ANG-(1-8) were measurable in all renal tissues. However, [3H]ANG-(1-8) was not detectable in any renal tissue. These observations suggest that ANG-(1-8) in the renal venous effluent was derived, in part, de novo from intrarenal generation. Likewise, renal tissue ANG-(1-8) was derived de novo from intrarenal generation.
authors.affiliation: Department of Medicine, University of Missouri, Columbia 65212.
authors.forename: G
authors.initials: G
authors.lastname: Reams
authors.forename: D
authors.initials: D
authors.lastname: Villarreal
authors.forename: J H
authors.initials: JH
authors.lastname: Bauer
mesh_terms: D000804:Angiotensin II / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001158:Arteries; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000378:metabolism*; D009994:Osmolar Concentration; D012079:Renal Circulation / Q000187:drug effects; D014680:Veins
chemical_list: D000804:Angiotensin II