title: [Sensitivity of bone marrow cells damaged by antitumor drugs to cytotoxic action of effectors of a normal spleen].
abstract: Different cytogenetic effects in bone marrow cells induced by antitumor drugs with different mechanisms of action was studied. The treatment of adriablastine causes the appearance of chromatid deletion, vinblastine-polyploid cells, cyclophosphamide-chromosomal and chromatid aberration in mice. It was shown that bone marrow cells with cytogenetic damage have altered susceptibility to normal spleen cells-effectors cytotoxic action.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Klimova
authors.forename: I V
authors.initials: IV
authors.lastname: Bogdashin
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000009:adverse effects; D003602:Cytotoxicity, Immunologic; D004317:Doxorubicin / Q000009:adverse effects; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D014747:Vinblastine / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide
vernacular_title: Chuvstvitel'nost' povrezhdennykh tsitostatikami kletok kostnogo mozga k tsitotoksicheskomu deĭstviiu éffektorov normal'noĭ selezenki.