Modifying effects of calcium on aluminum induced toxicity in mammalian tissues in vivo.
Oral administration of calcium, following by aluminium or together with Al, has been found to counteract the toxic effects of the latter metal as observed in histological preparations of liver, brain, kidney, and bone of laboratory albino rats. No such improvement was seen if Ca was administered after Al. The protection afforded by Ca against Al toxicity may be due to the previous occupation by Ca ions of the binding sites of Al ions in the affected organs.
Roy
A K
AK
Department of Botany, University of Calcutta, India.
Talukder
G
G
Sharma
A
A
D000535:Aluminum / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051381:Rats
D000535:Aluminum; D002118:Calcium