[The distribution of 125I-monoclonal antibodies to Bence Jones proteins in the body of animals].
A study was made of the biodistribution of 125I-labeled (chloramine, lactoperoxidase and iodogen tracer methods) monoclonal antibodies to free lambda and kappa chains of human immunoglobulins (Bence Jones proteins) using experimental models: ACR mice with a depot of antigen in the muscular tissue. Labeled MAB were shown to preserve their immunological properties. The results of investigation into biodistribution helped to reveal selective accumulation of radioactivity in the antigen depot (Bence Jones protein).
Miroliubova
O Iu
OIu
Makarenko
M V
MV
Klimovich
V B
VB
Serzhanina
V A
VA
Korsakova
L N
LN
Fadeev
N P
NP
D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000493:pharmacokinetics*; D001536:Bence Jones Protein / Q000276:immunology*; D002850:Chromatography, Gel; D004797:Enzyme-Linked Immunosorbent Assay; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007553:Isotope Labeling; D051379:Mice; D008806:Mice, Inbred AKR; D013997:Time Factors; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D001536:Bence Jones Protein
Raspredelenie 125I-monoklonal'nykh antitel k belkam Bens-Dzhonsa v organizme zhivotnykh.