title: Sucralfate significantly reduces ciprofloxacin concentrations in serum.
abstract: The effect of sucralfate on the bioavailability of ciprofloxacin was evaluated in eight healthy subjects utilizing a randomized, crossover design. The area under the concentration-time curve from 0 to 12 h was reduced from 8.8 to 1.1 micrograms.h/ml by sucralfate (P less than 0.005). Similarly, the maximum concentration of ciprofloxacin in serum was reduced from 2.0 to 0.2 micrograms/ml (P less than 0.005). We conclude that concurrent ingestion of sucralfate significantly reduces the concentrations in serum produced by a 500-mg dose of ciprofloxacin. On the basis of these findings, ciprofloxacin and sucralfate should not be administered concurrently.
authors.affiliation: Department of Pharmacy, St. Francis Regional Medical Center, Wichita, Kansas.
authors.forename: J C
authors.initials: JC
authors.lastname: Garrelts
authors.forename: P J
authors.initials: PJ
authors.lastname: Godley
authors.forename: J D
authors.initials: JD
authors.lastname: Peterie
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: C C
authors.initials: CC
authors.lastname: Yakshe
mesh_terms: D000328:Adult; D001682:Biological Availability; D002939:Ciprofloxacin / Q000097:blood*; D003864:Depression, Chemical; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D013392:Sucralfate / Q000494:pharmacology*
chemical_list: D013392:Sucralfate; D002939:Ciprofloxacin