Pharmacological mobilization of haemopoietic progenitor cells in human peripheral blood.
We investigated Prednisone (PRD) and Folinic Acid (FA) ability to recruit stem cells (CFU-S) into the circulating compartment, evaluating CFU-GM, BFU-E and CFU-GEMM count increases in peripheral blood (PB). Fifteen healthy donors were administered 75 mg PRD in one trial, and 15 mg FA p.o. through 5 consecutive days in another trial. We observed a significant expansion for BFU-E and CFU-GEMM compartments, though not parallelled by CFU-GM expansion. FA determined a significant increase in CFU-GM on the 5th day of administration, as well as in BFU-E on day 7. It fails to raise CFU-GEMM. The authors suggest a less empiric persuing for such attempts to optimize the use of non-chemotherapic drugs to recruit hemopoietic precursors into PB, so that these can suit to meet stem cell needs for autologous and allogeneic transplantations.
Berardi
A
A
Divisione di Ematologia e Centro Trasfusionale, Ospedale Civile, Pescara, Italy.
Geraci
L
L
Quaglietta
A M
AM
Di Bartolomeo
G
G
Dragani
A
A
D000328:Adult; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D002955:Leucovorin / Q000494:pharmacology*; D008297:Male; D011241:Prednisone / Q000494:pharmacology*
D002955:Leucovorin; D011241:Prednisone