title: [Chimerism pattern following allogeneic bone marrow transplantation; a retrospective study of the connection with post-transplantation complications].
abstract: Allogeneic bone marrow transplantation is generally followed by disappearance of all host haematopoietic cells and replacement by donor cells, resulting in complete chimerism. In some cases, however, residual host cells can be detected after transplantation; this is called partial chimerism. We have analysed the chimerism pattern in 106 patients, by erythrocyte antigen typing, erythrocyte and leucocyte isoenzymes, immunoglobulin allotyping and karyotyping of bone marrow and blood. Recipients of a T cell-depleted marrow transplant exhibited partial chimerism significantly more often. In most cases this involved T lymphocytes, sometimes in combination with other cell populations. Persisting B lymphocytes of host origin were detected only in recipients of a T cell-depleted marrow graft. No relationship was found between chimerism pattern and GVHD, interstitial pneumonitis, relapse of the underlying disease or disease free survival.
authors.affiliation: Academisch Ziekenhuis, afd. Hematologie, Leiden.
authors.forename: A M
authors.initials: AM
authors.lastname: Vlieger
authors.forename: D J
authors.initials: DJ
authors.lastname: Richel
authors.forename: F E
authors.initials: FE
authors.lastname: Zwaan
authors.forename: G C
authors.initials: GC
authors.lastname: Beverstock
authors.forename: R
authors.initials: R
authors.lastname: Willemze
authors.forename: W E
authors.initials: WE
authors.lastname: Fibbe
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002678:Chimera / Q000235:genetics* / Q000276:immunology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000145:classification; D007527:Isoenzymes / Q000032:analysis; D007621:Karyotyping; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D010641:Phenotype; D014184:Transplantation, Homologous
chemical_list: D007136:Immunoglobulins; D007527:Isoenzymes
vernacular_title: Chimerismepatroon na allogene beenmergtransplantatie; een retrospectief onderzoek naar het verband met complicaties na transplantatie.