[Toxicity of cis-platinum loaded with lactic acid oligomer microspheres in mice].
We have evaluated the acute toxicity of an experimental new dosage form administered intraperitoneally in mice, consisting of cis-platinum loaded with lactic acid oligomer microspheres (CDDP-ms). The LD50 value of the CDDP-ms was 23.8 mg/kg, which amounted to 176% of the LD50 of the cis-platinum solution (13.5 mg/kg). Autopsy findings revealed no additional toxicity due to this dosage form.
Sasabe
T
T
1st Dept. of Surgery, Kyoto Prefectural Univ.
Takahashi
T
T
Hagiwara
A
A
Iwamoto
A
A
Shimotsuma
M
M
Yoneyama
C
C
Itoh
M
M
Hyon
S H
SH
Ikeda
Y
Y
Kusanoi
Y
Y
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D011108:Polymers
D007773:Lactates; D011108:Polymers; D019344:Lactic Acid; D002945:Cisplatin