Selective deuteration of 4-N-methylcytosines.
A convenient photochemical method of preparation of mono-, di- and trideuterate 4-N-methylcytosines of high isotopic purity is described. These products were obtained by photo-decarboxylation of pyrimidinyl glycines or their alpha, alpha-dideuterated derivatives in water or in deuterium oxide. [2, 2H2]Glycine derivatives were prepared by hydrogen-deuterium exchange in alkaline solution.
Spychała
J
J
Adam Mickiewicz University, Faculty of Chemistry, Poznań, Poland.
Golankiewicz
K
K
D002247:Carbon Isotopes; D003596:Cytosine / Q000031:analogs & derivatives*; D003903:Deuterium; D006859:Hydrogen; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010777:Photochemistry
D002247:Carbon Isotopes; D007202:Indicators and Reagents; C039052:N(4)-methylcytosine; D006859:Hydrogen; D003596:Cytosine; D003903:Deuterium