Effect of graded adrenaline infusion on arterial adrenaline clearance in normotensive and hypertensive man.
1. Arterial adrenaline (ADR) levels were measured during graded ADR infusions in normotensives (NT) and in mild hypertensives (HT), in order to test the hypothesis that ADR enhances its own clearance in NT. 2. Although infusion of ADR resulted in similar arterial ADR levels in NT and HT, increases in systolic blood pressure (SBP) and heart rate (HR) and decreases in diastolic blood pressure (DBP) were greater during ADR infusion in HT than in NT. 3. Twenty minutes after cessation of infusion, SBP and HR remained elevated in HT but not in NT. 4. No evidence was found supporting enhanced ADR clearance during increasing ADR levels in NT or HT.
Bachmann
A W
AW
University of Queensland, Department of Medicine, Greenslopes Hospital, Brisbane, Australia.
Gordon
R D
RD
Bathgate
R A
RA
Thompson
R E
RE
D000328:Adult; D001158:Arteries; D001794:Blood Pressure / Q000187:drug effects; D004334:Drug Administration Schedule; D004837:Epinephrine / Q000008:administration & dosage / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D012016:Reference Values
D004837:Epinephrine