title: Recurrent interstitial cystitis following cystoplasty: fact or fiction?
abstract: The severity of symptoms in interstitial cystitis may necessitate surgical treatment in approximately 10% of the patients. Substitution cystoplasty provides satisfactory results in most of these cases, while avoiding the need for urinary diversion. It has been suggested that interstitial cystitis may affect the bowel segment used in this form of operation. We studied bowel segments removed from cystoplasties in 5 patients with interstitial cystitis and compared these to bowel used for lower urinary reconstruction for other disorders in 6 patients. All segments showed varying degrees of inflammation, fibrosis and mastocytosis but there was no difference between the 2 groups for these features. We conclude that inflammation and fibrosis is the usual reaction of bowel to exposure to urine, and they do not represent a specific spread of interstitial cystitis in those patients. However, this reaction does mimic the histological appearance of interstitial cystitis in the bladder and may suggest a model for this disease.
authors.affiliation: Department of Urology, University of California Davis, Sacramento 95817.
authors.forename: J P
authors.initials: JP
authors.lastname: MacDermott
authors.forename: G L
authors.initials: GL
authors.lastname: Charpied
authors.forename: H
authors.initials: H
authors.lastname: Tesluk
authors.forename: A R
authors.initials: AR
authors.lastname: Stone
mesh_terms: D000328:Adult; D003556:Cystitis / Q000209:etiology*; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology / Q000637:transplantation*; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D001743:Urinary Bladder / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects