title: A novel antibacterial diterpene from Premna schimperi.
abstract: A novel diterpene, (5R, 8R, 9S, 10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid, has been obtained from the leaves of Premna schimperi (Verbenaceae) using an anti-microbial bioassay-guided isolation procedure. The diterpene was identified on the basis of spectroscopic data and is active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis in the concentration range 20-25 micrograms ml-1.
authors.affiliation: Department of Chemistry, Addis Ababa University, Ethiopia.
authors.forename: S
authors.initials: S
authors.lastname: Habtemariam
authors.forename: A I
authors.initials: AI
authors.lastname: Gray
authors.forename: G W
authors.initials: GW
authors.lastname: Halbert
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes