[Cytogenetic studies of human lymphocytes under the influence of oxicams].
The influence of the oxicams, a special group of non-steroidal anti-inflammatory drugs, to the sister chromatid exchange (SCE) was determined on human lymphocytes in vitro and in vivo. The analysis of SCE is a sensitive parameter indicating chromosomal damage. The cytogenetic examinations of Lornoxicam, Tenoxicam, and Piroxicam in vitro showed no influence on the SCE frequencies in therapeutic dosages. With addition of mitomycin C (MMC) to the cultures (a method which simulates an additional genotoxic stress) we found significant higher SCE rates in connection with the oxicams than in controls without an oxicam. A 14-day treatment with Tenoxicam and Lornoxicam changed the spontaneous SCE rates in vivo; Piroxicam did not. The raised SCE levels could indicate an antimutagenic effect of the oxicams if the repair of DNA damages is transferred to a more perfect pathway; however by an overloading of the repair, due to additional genotoxic factors (such as cytostatics, cigarette smoking, x-ray exposure) therapy with oxicams could point out a genotoxic risk.
Kullich
W
W
Ludwig-Boltzmann-Institut für Rehabilitation interner Erkrankungen, Saalfelden.
Hermann
J
J
Klein
G
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured / Q000187:drug effects; D002869:Chromosome Aberrations / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012216:Rheumatic Diseases / Q000097:blood / Q000188:drug therapy; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000235:genetics; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C013580:isoxicam; C032801:tenoxicam
Zytogenetische Untersuchungen an humanen Lymphozyten unter dem Einfluss von Oxicamen.