[Changes in cell membrane proteins during N-nitrosodiethylamine induced carcinogenesis].
The composition of rat liver cell membrane proteins during the N-nitrosodiethylamine-induced hepatocarcinogenesis was studied using polyacrylamide gel electrophoresis. The effect of the carcinogen on rat liver was controlled by the catalase activity in the microsomal fractions. The plasma membrane protein fractions with Mr of 140 kDa, 135 kDa, 40 kDa and 22 kDa as well as the 36 kDa fraction from endoplasmic reticulum membranes were found to decrease during hepatocarcinogenesis.
Berdinskikh
N K
NK
Korol'
D R
DR
Livshits
V I
VI
D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004048:Diethylamines / Q000494:pharmacology; D004052:Diethylnitrosamine; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D008970:Molecular Weight; D051381:Rats
D004048:Diethylamines; D008565:Membrane Proteins; D004052:Diethylnitrosamine; C034281:diethylamine; D002374:Catalase
Izmeneniia belkov kletochnykh membran v protsesse kantserogeneza, vyzvannogo N-nitrozodiétilaminom.