title: Role of centralization of surgery in Stage IB carcinoma of the cervix: a review of 498 cases.
abstract: A review was undertaken of 498 patients with stage IB carcinoma of the cervix managed over a 15-year period in the Regional Gynaecological Oncology Centre, Gateshead. All but 4 were treated by radical hysterectomy, with adjuvant radiotherapy and/or chemotherapy for those with involved pelvic nodes. The overall 5-year survival in those with negative nodes was 91.4% compared with 50.5% in those with positive nodes (P less than 0.05). Of those dying from the disease, 7 patients only (1.4%) developed central recurrence, the remainder experiencing pelvic side-wall or distant recurrence. There was no difference in survival related to patient age. There were three deaths related to surgery and a fistula rate of only 1.2%. Bladder hypotonia and lymphocyst affected a minority of patients in the long term. The data support the case for radical surgery in stage IB carcinoma of the cervix, managed on a centralized referral basis.
authors.affiliation: Regional Department of Gynaecological Oncology, Queen Elizabeth Hospital, Gateshead, Tyne and Wear, England.
authors.forename: J M
authors.initials: JM
authors.lastname: Monaghan
authors.forename: D
authors.initials: D
authors.lastname: Ireland
authors.forename: S
authors.initials: S
authors.lastname: Mor-Yosef
authors.forename: S E
authors.initials: SE
authors.lastname: Pearson
authors.forename: A
authors.initials: A
authors.lastname: Lopes
authors.forename: D P
authors.initials: DP
authors.lastname: Sinha
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D013534:Survival; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*