title: [The effect of sermion on the main hemodynamic indices in patients with the initial manifestations of cerebral atherosclerosis].
abstract: It has been found that the drug sermion (nicergoline)--a synthetic ergot alkaloid with alpha-adrenoblocking action--produces a pronounced vasoactive (spasmolytic) effect in the elderly patients suffering of initial atherosclerotic encephalopathy. A course of sermion treatment improves, via its effect on the brain and lower extremity vessels, the flow in most involved vascular regions. High concentrations of the drug after intravenous administration of 4 mg of sermion (nicergoline) result in a rise of the sympathetic vascular tone, high adrenoblocking action.
authors.forename: A V
authors.initials: AV
authors.lastname: Tokar'
authors.forename: N G
authors.initials: NG
authors.lastname: Akhaladze
authors.forename: L M
authors.initials: LM
authors.lastname: Ena
authors.forename: E S
authors.initials: ES
authors.lastname: Rudaia
authors.forename: N L
authors.initials: NL
authors.lastname: Severova
mesh_terms: D000284:Administration, Oral; D000368:Aged; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D004341:Drug Evaluation; D004873:Ergolines / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007275:Injections, Intravenous; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D009530:Nicergoline / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D004873:Ergolines; D009530:Nicergoline
vernacular_title: Vliianie sermiona na osnovnye pokazateli gemodinamiki u bol'nykh s nachal'nymi proiavleniiami tserebral'nogo ateroskleroza.