Etiology of the disruption in blood-arterial wall barrier following experimental subarachnoid hemorrhage.
Aneurysmal subarachnoid hemorrhage is associated with a sudden rise in intracranial pressure, acute arterial hypertension, and subarachnoid blood. The role that each of these factors may play in the development of the acute barrier disruption of the major cerebral arteries following subarachnoid hemorrhage was investigated in 42 rabbits. Horseradish peroxidase was given intravenously to assess the integrity of the barrier by transmission electron microscopy. Permeation of the tracer into the vessel was noted only in animals with increased intracranial pressure. A sudden rise in intracranial pressure is suggested to trigger acute barrier disruption following subarachnoid hemorrhage.
Nakagomi
T
T
Department of Neurological Surgery, University of Tokyo Hospital, Japan.
Kassell
N F
NF
Sasaki
T
T
Lehman
R M
RM
Fujiwara
S
S
D000818:Animals; D001769:Blood / Q000378:metabolism*; D001794:Blood Pressure; D002199:Capillary Permeability; D002536:Cerebral Arteries / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D006735:Horseradish Peroxidase; D007267:Injections; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
D006735:Horseradish Peroxidase