The effect of platelet releasate on wound healing in animal models.
The alpha granules of platelets contain growth factors that are important in wound healing. We found that a major effect of thrombin-induced human platelet releasates in animal models of wound healing is to enhance the development of granulation tissue and new connective tissue matrix. These studies provide further evidence that platelet-derived protein factors may be useful in treating full-thickness dermal wounds by increasing the rate of granulation tissue formation.
Ksander
G A
GA
Celtrix Laboratories, Collagen Corporation, Palo Alto, CA 94303.
Sawamura
S J
SJ
Ogawa
Y
Y
Sundsmo
J
J
McPherson
J M
JM
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D003238:Connective Tissue / Q000502:physiology; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000502:physiology; D005260:Female; D006097:Granulation Tissue / Q000502:physiology; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D010978:Platelet Factor 4 / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D015291:Transforming Growth Factors / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D010982:Platelet-Derived Growth Factor; D010978:Platelet Factor 4; D015291:Transforming Growth Factors