title: HLA-B7 and HLA-DR2 antigens and acute posterior multifocal placoid pigment epitheliopathy.
abstract: Acute posterior multifocal placoid pigment epitheliopathy is a chorioretinal inflammatory disease occurring in young, healthy adults. Its cause is unknown, although it frequently follows a flulike illness. We reexamined 30 patients with documented acute posterior multifocal placoid pigment epitheliopathy to determine their HLA class I antigen (A and B) and class II antigen (DR and DQ) distribution. The HLA class I antigen B7 was found in 12 patients (40.0%) compared with 63 controls (16.6%) (relative risk, 3.38). The class II antigen DR2 was present in 17 patients (56.7%) compared with 107 controls (28.2%) (relative risk, 3.34). The specific role of HLA antigens in uveitis is unknown, but the finding of an increased prevalence of HLA-B7 and HLA-DR2 antigens in patients with acute posterior multifocal placoid pigment epitheliopathy suggests an immunogenetic predisposition to acquiring this disease.
authors.affiliation: Department of Ophthalmology, University of Iowa, Iowa City.
authors.forename: M D
authors.initials: MD
authors.lastname: Wolf
authors.forename: J C
authors.initials: JC
authors.lastname: Folk
authors.forename: C A
authors.initials: CA
authors.lastname: Panknen
authors.forename: N E
authors.initials: NE
authors.lastname: Goeken
mesh_terms: D002825:Chorioretinitis / Q000276:immunology*; D005260:Female; D015793:HLA-B7 Antigen / Q000032:analysis*; D015802:HLA-DR2 Antigen / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D015793:HLA-B7 Antigen; D015802:HLA-DR2 Antigen; D015395:Histocompatibility Antigens Class I