title: Control of bleeding in cemented arthroplasty.
abstract: Bleeding from cancellous bone causes lamination within bone cement and at its prosthetic interfaces, and weakens the fixation of joint replacements. We examined the effects of anaesthesia and blood pressure on bleeding in human cancellous bone, and investigated the local response to freezing saline, 1:200,000 adrenaline and hydrogen peroxide. Spinal anaesthesia reduced cancellous bleeding by an average of 44%, local freezing saline by 24%. Saline at room temperature, adrenaline solution and hydrogen peroxide each reduced it by 14%. The effects of spinal anaesthesia and of freezing saline were additive: used together they reduced bleeding by 56%. The reduction of blood contamination of cement and its interfaces should contribute to better prosthetic fixation.
authors.affiliation: Winford Orthopaedic Hospital, Bristol.
authors.forename: G C
authors.initials: GC
authors.lastname: Bannister
authors.forename: S K
authors.initials: SK
authors.lastname: Young
authors.forename: A S
authors.initials: AS
authors.lastname: Baker
authors.forename: J G
authors.initials: JG
authors.lastname: Mackinnon
authors.forename: P A
authors.initials: PA
authors.lastname: Magnusson
mesh_terms: D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D001760:Bleeding Time; D001843:Bone Cements; D004837:Epinephrine / Q000627:therapeutic use; D005615:Freezing; D006470:Hemorrhage / Q000517:prevention & control*; D006488:Hemostasis, Surgical / Q000379:methods*; D006622:Hip Prosthesis; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D001843:Bone Cements; D012965:Sodium Chloride; D006861:Hydrogen Peroxide; D004837:Epinephrine