[Effects of plant polysaccharide paliustran on the growth of human tumor transplants in athymic mice].
Plant polysaccharide palyustran inhibited the growth of human lung carcinoma P-1 transplanted to athymic mice by 60% but failed to do so in human rhabdomyosarcoma. Treatment with palyustran was followed by a 2-fold decrease in lympho- and granulocyte levels, selective inhibition of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase activity in tumor cells and--in single cases--metastatic involvement of the liver.
Bukharova
I K
IK
Osokina
L I
LI
Revazova
E S
ES
Moroz
L V
LV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000201:enzymology; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000097:blood / Q000378:metabolism
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D011134:Polysaccharides; C047612:palustran; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase
Vliianie rastitel'nogo polisakharida paliustrana na rost transplantatov opukholeĭ cheloveka u bestimusnykh mysheĭ.