title: Excess of seminomas observed in Vietnam service U.S. military working dogs.
abstract: During the Vietnam War, US military working dogs served with their companion dog handlers in close proximity, sharing common exposures to war-related activity, many zoonotic infectious agents, chemical pesticides, phenoxy herbicides, and extensive use of therapeutic drugs. To gain insight into the effects of the Vietnam experience, we investigated the occurrence of neoplasms in military working dogs based on standard necropsy examination by the Armed Forces Institute of Pathology. We observed that these dogs experienced significant elevated risks for testicular seminoma and, independently, testicular dysfunction. Experimental evidence shows testicular dysfunction and impaired spermatogenesis in laboratory animals exposed to phenoxy herbicides, dioxin, or tetracycline, and antibiotic used extensively in military working dogs in Vietnam. Because an unexplained significant decrease in sperm quality in Vietnam veterans has been observed by the Centers for Disease Control, further research is warranted if we are to clarify military service in Vietnam as a risk factor for testicular dysfunction. The testis should be made a priority site in the study of Vietnam experience-related cancers.
authors.affiliation: Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: H M
authors.initials: HM
authors.lastname: Hayes
authors.forename: R E
authors.initials: RE
authors.lastname: Tarone
authors.forename: H W
authors.initials: HW
authors.lastname: Casey
authors.forename: D L
authors.initials: DL
authors.lastname: Huxsoll
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000453:epidemiology; D004285:Dogs; D004407:Dysgerminoma / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*; D008297:Male; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000139:chemically induced / Q000662:veterinary*; D013752:Tetracycline / Q000009:adverse effects; D014481:United States / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology; D014857:Warfare
chemical_list: D013752:Tetracycline