[Activation of endogenous lipid peroxidation in the brain in oxidation stress caused by administration of iron and its prevention by vitamin E].
Looking for an appropriate model of accelerated aging in vivo we investigated the content of endogenous products of lipid peroxidation (LP) in the rat brain after single or 4 day-lasting intramuscular injection of complex-bind iron (ferum Hausman, 50 mg/kg body weight) like promoter of LP. We found that the single administration of this iron complex fails to induce endogenous LP; after 4 day-application of iron we observed significant increase in content of primary (lipid peroxides) and final (fluorescent) products of LP. Iron-promoted activation of endogenous LP could be abolished by animal pretreatment with the natural antioxidant alpha-tocopherol. The calcium antagonist nifedipine didn't affect the content of endogenous LP products neither alone nor in combination with alpha-tocopherol.
Kaĭnova
G M
GM
Markovska
D
D
Staneva
D
D
Kagan
V E
VE
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005453:Fluorescence; D007273:Injections, Intramuscular; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D014810:Vitamin E; D007501:Iron; D009543:Nifedipine
Aktivatsiia éndogennogo perekisnogo okisleniia lipidov v mozge pri okislitel'nom stresse, vyzvannom vvedeniem zheleza, i ee predotvrashchenie vitaminom E.