Analysis of meiotic segregation in a man heterozygous for a 13;15 Robertsonian translocation and a review of the literature.
Meiotic segregation was studied in a male heterozygous for a 13;15 Robertsonian translocation using in vitro sperm penetration of hamster eggs. Sixty-seven sperm chromosome complements were obtained and R-banded. Alternate segregation produced equal numbers of normal (31) and balanced (29) gametes, as was theoretically expected. Incidence of unbalanced complements was 10.4%, and the frequency of abnormalities unrelated to the translocation was 7.4%. This study confirms the predominance of alternate meiotic segregation in Robertsonian translocation carriers. Four sperm studies of Robertsonian translocation have been previously reported. A review of the combined results points out the low incidence of imbalance in the sperm of Robertsonian translocation carrier and the lack of evidence for an interchromosomal effect.
Pellestor
F
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Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, La Tronche, France.
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002884:Chromosomes, Human, Pair 15; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D010375:Pedigree; D013094:Spermatozoa / Q000166:cytology / Q000648:ultrastructure; D014178:Translocation, Genetic / Q000235:genetics*