Hemolytic-uremic syndrome following "crack" cocaine inhalation.
The authors present a patient who experienced cocaine-related thrombotic microangiopathy and patchy renal cortical necrosis, associated with the clinical syndrome of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, characteristics of the Hemolytic-Uremic syndrome. The proposed pathogenetic mechanisms include: (1) cocaine-induced vasoconstriction and endothelial damage and (2) procoagulant effects of cocaine.
Tumlin
J A
JA
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.
Sands
J M
JM
Someren
A
A
D000280:Administration, Inhalation; D000328:Adult; D001706:Biopsy; D001777:Blood Coagulation / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006435:Renal Dialysis; D019966:Substance-Related Disorders / Q000150:complications*; D014661:Vasoconstriction / Q000187:drug effects
D003042:Cocaine