Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome.
A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to +/- 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.
Devor
E J
EJ
Department of Psychiatry, Washington University School of Medicine, St. Louis, Mo.
Grandy
D K
DK
Civelli
O
O
Litt
M
M
Burgess
A K
AK
Isenberg
K E
KE
van de Wetering
B J
BJ
Oostra
B
B
D002880:Chromosomes, Human, Pair 11; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D011954:Receptors, Dopamine / Q000235:genetics*; D005879:Tourette Syndrome / Q000235:genetics*
D015342:DNA Probes; D011954:Receptors, Dopamine