Angiotensin-converting enzyme inhibitors in the treatment of diabetic glomerulopathy.
Continuous therapy with an angiotensin-converting enzyme (ACE) inhibitor has been shown to have a glomerular vasodepressor effect in the newly diabetic rat and to largely prevent subsequent development of severe sclerosing glomerular injury. Preliminary studies in humans with established diabetic glomerular injury reveal that ACE inhibitor therapy has an antiproteinuric effect and may also slow the decline in glomerular filtration rate that usually attends this disorder. Although promising, the human studies are inconclusive because of short duration and other limitations in experimental technique and study design. Additional trials are required to confirm more positively this amelioration of human diabetic glomerular injury by ACE inhibitor therapy.
Myers
B D
BD
Department of Medicine, Stanford University School of Medicine, Calif.
Meyer
T W
TW
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D003921:Diabetes Mellitus, Experimental; D003925:Diabetic Angiopathies / Q000517:prevention & control; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D006940:Hyperemia / Q000517:prevention & control; D006973:Hypertension / Q000517:prevention & control; D051381:Rats
D000806:Angiotensin-Converting Enzyme Inhibitors