title: Assessment of loosely-bound and firmly-bound fluoride uptake by tooth enamel from topically applied fluoride treatments.
abstract: The amounts of loosely-bound fluoride (F) deposited on human enamel by two topical F treatments were measured with use of a constant-composition F washing method. Enamel biopsies conducted before treatment and after the washing were used for determination of the firmly-bound F uptake. The results showed that (1) the washing system did not remove F from untreated enamel surface, (2) a four-minute application of an acidulated phosphate fluoride (APF) gel deposited 27.2 (2.4) (mean, S.E.) micrograms of loosely-bound F per cm2 of enamel surface and 186 (111) ppm of firmly-bound F in the outer 10 microns of enamel, and (3) a four-minute application of a pH-2.1 dicalcium phosphate dihydrate (DCPD)-forming solution followed by APF produced 44.9 (3.1) micrograms/cm2 of loosely-bound F and 1280 (354) ppm of firmly-bound F in the outer 10 microns of enamel. The results showed that the DCPD pre-treatment effectively enhanced the enamel reactivity with F, so that the DCPD-APF treated enamel acquired greater amounts of both loosely-bound F and firmly-bound F than did samples treated with APF alone.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
authors.forename: B
authors.initials: B
authors.lastname: Sieck
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003743:Dental Enamel / Q000378:metabolism*; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics*; D005460:Fluorides, Topical / Q000627:therapeutic use*; D005782:Gels; D012969:Sodium Fluoride
chemical_list: D002130:Calcium Phosphates; D005460:Fluorides, Topical; D005782:Gels; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D000149:Acidulated Phosphate Fluoride; C485838:calcium phosphate, monobasic, anhydrous; D012969:Sodium Fluoride; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D005459:Fluorides