L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
L-Alanine: 4,5-dioxovalerate transaminase (ADT) was determined in liver homogenates of rats treated by either inducers of porphyrin synthesis or the repressor, hemin. ADT activity was not induced by the porphyrinogenic agents nor reduced by hemin, indicating that ADT probably has no regulatory role in the heme synthesis pathway. The same conclusion was drawn from similar experiments performed in monolayers of chick embryo liver cells.
Mamet
R
R
Laboratory of Biochemical Pharmacology, Beilinson Medical Center, Petah Tiqva, Israel.
Mevasser
R
R
Bomstein
Y
Y
Atsmon
A
A
Schoenfeld
N
N
D000409:Alanine / Q000378:metabolism; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000622:Aminolevulinic Acid / Q000378:metabolism; D000818:Animals; D002642:Chick Embryo; D003997:Dicarbethoxydihydrocollidine / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D006418:Heme / Q000096:biosynthesis*; D006427:Hemin / Q000494:pharmacology; D008099:Liver / Q000196:embryology / Q000201:enzymology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D011166:Porphyrins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000378:metabolism*; D014631:Valerates / Q000378:metabolism
D011166:Porphyrins; D014631:Valerates; D000502:Allylisopropylacetamide; D006418:Heme; C007509:4,5-dioxovaleric acid; D003997:Dicarbethoxydihydrocollidine; D006427:Hemin; D000622:Aminolevulinic Acid; D000637:Transaminases; C019687:aminolevulinate aminotransferase; D000409:Alanine; D010634:Phenobarbital