Influence of nootropic drugs on apomorphine-induced stereotyped behaviour in rats.
In an attempt to identify the functional role of cerebral dopaminergic processes for the action of nootropic drugs the influence of piracetam, meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate on apomorphine-induced stereotyped behaviour was studied. Meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate enhanced significantly the apomorphine-elicited stereotypy in rats without triggering the behaviour itself. Piracetam (300, 500 or 1000 mg/kg ip.) was ineffective in this test. These results support the assumption that the functional activation of cerebral aminergic processes plays a possible role in the mode of action of some typical representatives of nootropic drugs.
Schmidt
J
J
Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, GDR.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D011619:Psychotropic Drugs; D001058:Apomorphine