title: Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus.
abstract: The three intramolecular disulfide linkages of geographutoxin I, a peptide neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986-1994]. The disulfide bridges were found to be between Cys3 and Cys15, Cys4 and Cys20, and Cys21, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.
authors.affiliation: Institute for Protein Research, Osaka University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hidaka
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: Y
authors.initials: Y
authors.lastname: Shimonishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004220:Disulfides / Q000032:analysis; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D008978:Mollusk Venoms; D009498:Neurotoxins; D010455:Peptides / Q000138:chemical synthesis* / Q000302:isolation & purification; D010456:Peptides, Cyclic; D011487:Protein Conformation; D012908:Snails
chemical_list: D004220:Disulfides; D008978:Mollusk Venoms; D009498:Neurotoxins; D010455:Peptides; D010456:Peptides, Cyclic; C038093:geographutoxin I