title: Effects of various concentrations of O2 and umbilical cord occlusion on fetal breathing and behavior.
abstract: To test the hypothesis that continuous fetal breathing could be induced by hyperoxemia alone or by hyperoxemia and umbilical cord occlusion, even in the absence of a rise in arterial PCO2 (PaCO2), we studied 18 chronically instrumented fetal sheep on 34 occasions using our window model (18). After a resting cycle (1 low-voltage followed by 1 high-voltage electrocortical activity epoch), the fetal lung was distended via an endotracheal tube using mean airway pressure of approximately cmH2O. Inspired N2, 17% O2, and 100% O2 were given to the fetus during one cycle each. While 100% O2 was given, the umbilical cord was occluded (balloon cuff).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
authors.forename: R J
authors.initials: RJ
authors.lastname: Baier
authors.forename: S U
authors.initials: SU
authors.lastname: Hasan
authors.forename: D B
authors.initials: DB
authors.lastname: Cates
authors.forename: D
authors.initials: D
authors.lastname: Hooper
authors.forename: B
authors.initials: B
authors.lastname: Nowaczyk
authors.forename: H
authors.initials: H
authors.lastname: Rigatto
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003250:Constriction; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006612:High-Frequency Ventilation; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D012756:Sheep; D014470:Umbilical Cord / Q000502:physiology*
chemical_list: D010100:Oxygen