title: Studies on antifungal agents. Novel cis-5-alkyl (or alkenyl)-3-phenyl-3-(1H-azol-1-ylmethyl)-2-methyl-isoxazolidine derivatives.
abstract: The preparation and in vitro antifungal activity of a novel series of cis-5-alkyl (or alkenyl)-3-phenyl-3-(1H-azol-1-ylmethyl)-2-methylisoxazol idines are described. The overall activity of the 3-(1H-imidazol-1-ylmethyl) analogues was higher than that of the corresponding 3-(1H-1,2,4-triazol-1-ylmethyl) derivatives. Compound 4b emerged as the most potent derivative. When compared to ketoconazole, several of the analogues tested demonstrated equipotent or superior activity against Trichophyton and Candida sp.
authors.affiliation: Department of Organic Chemistry, Fisons Pharmaceuticals, Rochester, NY.
authors.forename: G A
authors.initials: GA
authors.lastname: Bennett
authors.forename: P A
authors.initials: PA
authors.lastname: Swift
authors.forename: G B
authors.initials: GB
authors.lastname: Mullen
authors.forename: J T
authors.initials: JT
authors.lastname: Mitchell
authors.forename: S D
authors.initials: SD
authors.lastname: Allen
authors.forename: V S
authors.initials: VS
authors.lastname: Georgiev
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis*
chemical_list: D000935:Antifungal Agents; D007555:Isoxazoles; D010080:Oxazoles