title: Comparison of 2.5% and 10% phenylephrine in the elevation of upper eyelids with ptosis.
abstract: The Mueller's muscle-conjunctival resection procedure has been effective in treating ptosis in eyelids that elevate upon instillation of topical 10% phenylephrine (Neo-Synephrine). The small risk of an adverse systemic reaction to phenylephrine could be even further decreased by using 2.5% phenylephrine instead of 10% phenylephrine. In order to assess the feasibility of using 2.5% phenylephrine instead of 10% phenylephrine in ptosis evaluation, we compared the amount of upper eyelid elevation produced by the two solutions. Thirty ptotic upper eyelids in 20 patients exposed to 10% phenylephrine rose an average of 0.2 mm higher than the same lids exposed to 2.5% phenylephrine. Although this difference was statistically significant, we suspect that the small magnitude of this difference would have little effect on the decision to perform a Mueller's muscle-conjunctival resection procedure or on the calculation of the amount of tissue to resect.
authors.affiliation: Department of Ophthalmology, University of Illinois, Chicago College of Medicine.
authors.forename: H J
authors.initials: HJ
authors.lastname: Glatt
authors.forename: D R
authors.initials: DR
authors.lastname: Fett
authors.forename: A M
authors.initials: AM
authors.lastname: Putterman
mesh_terms: D001763:Blepharoptosis / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005143:Eyelids / Q000187:drug effects* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000601:surgery; D010656:Phenylephrine; D011237:Predictive Value of Tests
chemical_list: D010656:Phenylephrine