Further characterization of borderline methicillin-resistant Staphylococcus aureus and analysis of penicillin-binding proteins.
Eighty-nine Staphylococcus aureus strains were grouped according to their susceptibility or resistance to methicillin and oxacillin. The role of beta-lactamase in borderline methicillin resistance was confirmed by tests with beta-lactamase inhibitors, particularly when salt-supplemented medium was used. A penicillin-binding protein assay indicated that borderline methicillin-resistant S. aureus strains do not produce PBP 2a.
Montanari
M P
MP
Institute of Microbiology, University of Ancona Medical School, Italy.
Tonin
E
E
Biavasco
F
F
Varaldo
P E
PE
D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D006602:Hexosyltransferases; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism*; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013211:Staphylococcus aureus / Q000187:drug effects*; D065093:beta-Lactamase Inhibitors
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D065093:beta-Lactamase Inhibitors; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D010400:Penicillin G; D008712:Methicillin; D010068:Oxacillin