Age-related changes in hyaluronate uptake by cultured fibroblasts.
Skin fibroblasts from chick embryos of 7 and 14 days incubation have been tested for their ability to bind, internalize and degrade [3H]-hyaluronan. Seven-day fibroblasts internalize and degrade a greater amount of labelled hyaluronan than 14-day cells. The implications of these findings in the regulation by the fibroblasts of extracellular matrix composition in glycosaminoglycans are discussed.
Evangelisti
R
R
Institute of Histology and General Embryology, University of Ferrara, Italy.
Stabellini
G
G
Carinci
P
P
D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D002642:Chick Embryo; D004705:Endocytosis; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism*; D012867:Skin / Q000166:cytology*
D006025:Glycosaminoglycans; D006820:Hyaluronic Acid