Stereologic analysis of ventral prostate of oxytocin-treated rats.
Ventral prostate response to oxytocin (OT) was examined in intact and castrated adult rats. The treatment consisted of 10 daily subcutaneous injections of 0.25 IU OT per 100 g body weight, which for orchiectomized rats began immediately after surgery. OT induced prostatic response only in castrated animals. Stereologic analysis revealed changes in the epithelial component, its total volume and surface being increased. The acinar lumen as well as the glandular weight were also enhanced. A possibility that the ventral prostate is the target organ for OT is discussed.
Popović
A
A
Department of Physiology, Faculty of Pharmacy, University of Belgrade, Yugoslavia.
Plećas
B
B
Milićević
Z
Z
Hristić
M
M
Jovović
D
D
D000818:Animals; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D010121:Oxytocin