title: Invasive Aspergillus infections complicating coronary artery bypass grafting.
abstract: Endovascular infection with Aspergillus species results in unacceptably high mortality of greater than 80% in most series. Failure to recognize the infection early during its clinical course contributes to its formidable lethality. Blood cultures almost never reveal organisms, as in our Cases 1 and 2. When considering a patient with fever, changing murmur, major systemic emboli, or splenomegaly, and with blood cultures negative for organisms months or even years after cardiac surgery, therefore, the physician should maintain a high index of suspicion for fungal endocarditis. The best opportunity to establish the diagnosis antemortem rests in careful histopathologic and microbiologic examination of infected emboli and vegetations. Most authors agree that a combined approach employing early valve replacement and aggressive antifungal chemotherapy with amphotericin B and perhaps flucytosine or rifampin represents the best option for treatment of endovascular Aspergillus infections.
authors.affiliation: Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem NC 27103.
authors.forename: S F
authors.initials: SF
authors.lastname: Weber
authors.forename: R G
authors.initials: RG
authors.lastname: Washburn
mesh_terms: D000368:Aged; D001021:Aortic Valve; D001228:Aspergillosis / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004696:Endocarditis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000209:etiology; D012501:Saphenous Vein / Q000637:transplantation; D013249:Sternum