[Contribution of the analysis of genotype to the diagnosis of malignant lymphoma with abundant epithelioid reaction. Apropos of a case].
The authors describe the case of a 67 year-old woman bearing a malignant lymphoma displaying two different histological patterns: a Lennert's lymphoma pattern in a cervical lymph node and a diffuse centroblastic lymphoma pattern in an axillary node. Immunophenotyping on frozen and paraffin sections showed a predominant positivity of T-cell markers in the cervical node, while the axillary lymphadenopathy exhibited a major positivity of B-cell markers and a restricted expression of the lambda light chain. However, genotyping provided the evidence of a single neoplastic B-cell clone proliferating in both cervical and axillary nodes. These findings suggest that histological pattern of Lennert's lymphoma is devoid of absolute specificity. Thus, genotypic analysis is a useful tool for the diagnosis of so-called "lymphoepithelioid lymphomas".
Xerri
L
L
Laboratoire d'Anatomie Pathologique, Institut Paoli-Calmettes, Marseille.
Horschowski
N
N
Lejeune
C
C
Harle
J R
JR
Carcassonne
Y
Y
Hassoun
J
J
D000368:Aged; D001365:Axilla; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology*; D009333:Neck; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
Apport de l'analyse génotypique au diagnostic des lymphomes malins avec réaction épithélioïde abondante. A propos d'un cas.