title: Effect of angiotensin II on the antitumor activity and cardiotoxicity of doxorubicin.
abstract: The effects of angiotensin II (AII) on the antitumor activity and cardiotoxicity of doxorubicin (DXR) were tested in rats bearing Walker 256/A carcinoma. The animals received 2, 4 or 6 mg/kg of DXR as a bolus i.v. injection, with or without a concurrent i.v. infusion of 2 micrograms/kg/min of AII, starting 1 h prior to DXR administration for a total of 6 h. Neither the antitumor activity, nor the myocardial toxicity of DXR, as assessed by ECG evaluation (Q alpha T duration), were affected by AII at the tested dose. 100% of the animals receiving 6 mg/kg of DXR with or without AII were cured from the tumor, but subsequently some of them developed toxic signs and eventually died within the 12th week after treatment. Rats receiving DXR + AII showed a higher long-term survival than those receiving DXR alone; therefore, a possible interference with other DXR-induced side effects, such as nephrotoxicity, is hypothesized.
authors.affiliation: Istituto di Farmacologia, Facolta di Scienze, Universita di Milano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Monti
authors.forename: L
authors.initials: L
authors.lastname: Paracchini
authors.forename: F
authors.initials: F
authors.lastname: Piccinini
authors.forename: C
authors.initials: C
authors.lastname: Rossi
authors.forename: F
authors.initials: F
authors.lastname: Formelli
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000804:Angiotensin II; D004317:Doxorubicin