Synthesis of new 1,5-diphenyl-3-1H-1,2,4-triazoles substituted with H-, alkyl, or carboxyl groups at C-3.
Amidines obtained from benzamides and DMF- or DMA-dimethylacetal were cyclized with phenylhydrazines to 3H- or 3-methyltriazoles. 3-Ethyltriazoles were synthesized from diacylamides. Triazole-3-carboxylic acides were prepared starting from anilines. The compounds were assayed in the rat adjuvant induced arthritis model. Some compounds show significant anti-inflammatory activity.
Czollner
L
L
Institute for Drug Research, Budapest, Hungary.
Szilágyi
G
G
Langó
J
J
Janáky
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014230:Triazoles