[Concentrations of serum HDL subfractions and apolipoprotein B in ischemic cerebrovascular disease].
The concentrations of HDL subfractions and apolipoprotein B were determined in 127 survivors of ischemic cerebrovascular disease (ICVD) confirmed by CT scanning. All these patients were classified into 3 groups according to the sites of the arterial lesion, the amount of infarction and the course of the disease. The levels of cholesterol in HDL subfractions (HDL2 and HDL3) were significantly reduced in the patient with ICVD. The level of ApoB was elevated significantly in these patients as compared with control group. No difference between acute stage group and recovery stage group was found on the levels of HDL subfractions and ApoB. It seemed that the abnormalities of the levels of HDL subfractions and ApoB might have existed prior to the onset of the stroke. It was found that the levels of HDL-C and HDL-C subfraction were significantly lower in the cortical artery group than in the perforating artery group. The amount of reduction of both HDL-C and HDL subfractions was inversely related to the size of the infarct volume in patients with ICVD. It was believed that the determination of concentration of HDL subfractions and ApoB and early correction of the ab-normality of lipoproteins metabolism might be of help in preventing or delaying the stroke.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood*; D002545:Brain Ischemia / Q000097:blood* / Q000473:pathology; D008076:Cholesterol, HDL / Q000097:blood* / Q000145:classification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D001055:Apolipoproteins B; D008076:Cholesterol, HDL