Relative bioavailability of methadone hydrochloride administered in chewing gum and tablets.
Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p greater than 0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.
Christrup
L L
LL
Department of Pharmaceutics, Royal Danish-School of Pharmacy, Copenhagen.
Angelo
H R
HR
Bonde
J
J
Kristensen
F
F
Rasmussen
S N
SN
D000328:Adult; D000368:Aged; D001682:Biological Availability; D002638:Chewing Gum; D002849:Chromatography, Gas; D006801:Humans; D008691:Methadone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D013607:Tablets
D002638:Chewing Gum; D013607:Tablets; D008691:Methadone