Consequences of severe copper deficiency are independent of dietary carbohydrate in young pigs.
The ability of carbohydrates (CHO), such as fructose and sucrose, to aggravate copper deficiency in rats and the recent dietary trends of Western human populations led to the suggestion that the Cu X CHO interaction may be pertinent to public health. This hypothesis was tested with pigs because their cardiovascular and gastrointestinal systems closely resemble those of humans. Weanling pigs were fed a diet containing either 59% sucrose or cornstarch with either deficient (0.8 mg/kg diet) or adequate (6.4 mg/kg) copper for 10 wk. Plasma and tissue copper, the activities of plasma ceruloplasmin ferroxidase and erythrocyte Cu,Zn-superoxide dismutase, hematocrits, and serum cholesterol and triglyceride were all decreased (p less than 0.05) and relative cardiac mass was increased (p less than 0.05) by severe dietary copper deficiency. The type of dietary CHO did not differentially influence the values of these variables. Thus, these data fail to support the hypothesis that the Cu X CHO interaction observed in rats represents a health risk for humans.
Schoenemann
H M
HM
Vitamin and Mineral Nutrition Laboratory, US Department of Agriculture, Beltsville, MD 20705.
Failla
M L
ML
Steele
N C
NC
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000008:administration & dosage / Q000172:deficiency* / Q000493:pharmacokinetics; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects; D006400:Hematocrit; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000008:administration & dosage; D013395:Sucrose / Q000008:administration & dosage; D013552:Swine; D014018:Tissue Distribution
D004040:Dietary Carbohydrates; D013395:Sucrose; D003300:Copper; D013213:Starch