title: Combined cataract implant and filtering surgery with 5-fluorouracil.
abstract: In this preliminary retrospective study, results of combined extracapsular cataract extraction, intraocular lens implantation, and filtering surgery with subconjunctival 5-fluorouracil (5-FU) injections in 22 eyes were compared with those obtained in a similar group without 5-FU injections. Five to 35 mg (mean, 17.3 mg) of 5-FU were administered to each eye in the 5-FU group. Intraocular pressure (IOP) was controlled with fewer medications postoperatively than preoperatively in both the 5-FU group and the control group. However, the 5-FU group demonstrated statistically significant greater improvement in IOP control than the control group (P = .043).
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Cincinnati, OH.
authors.forename: J S
authors.initials: JS
authors.lastname: Cohen
mesh_terms: D000368:Aged; D002387:Cataract Extraction; D015350:Contrast Sensitivity / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000601:surgery*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007910:Lenses, Intraocular; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D005472:Fluorouracil