title: The effect of foot-shock on the noxious-evoked activity of neurons in the rostral ventral medulla.
abstract: The effect of foot-shock on the noxious-evoked activity of rostral ventral medulla (RVM) neurons was investigated in anesthetized rats. Neurons were first classified as on-cells if they fired faster during noxious pinch or as off-cells if they fired slower. Exposure to a 20 Hz squarewave at 2.5 or 3.5 mA administered for two minutes decreased the noxious-evoked responses of both cell types: on-cells showed a reduced increase in firing, while off-cells showed a reduced decrease in firing. The results indicate that stress-induced analgesia is accompanied by alterations in the activity of on- and off-cells.
authors.affiliation: Department of Psychology, Brown University, Schrier Research Laboratory, Providence, RI 02912.
authors.forename: M W
authors.initials: MW
authors.lastname: Friederich
authors.forename: J M
authors.initials: JM
authors.lastname: Walker
mesh_terms: D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains