title: A method for delivery of precise doses of smoked cocaine-base to humans.
abstract: Despite increasing smoked cocaine-base use, there have been relatively few parametric studies in this area. The major reason for the limited number of studies is the lack of a simple procedure for the administration of precise doses of smoked cocaine-base to human volunteers. This paper describes a new method that allows for the delivery of precise doses of smoked cocaine-base. A complete description of the method and the precision of the administration procedure are presented. Furthermore, a study is described which was undertaken to determine: 1) the reproducibility of peak blood cocaine levels when the same dose of cocaine was given on two separate occasions; and 2) the dose-related effects on smoking topography, biochemical, physiological and subjective measures. Subjects (N = 5) were administered three doses of cocaine-base (10, 20 and 40 mg). Four subjects were given repeated doses of cocaine-base. Subjects were blind to the dose and in most cases randomly assigned to different doses. The results showed: 1) a significant correlation of peak whole blood cocaine concentrations among similar doses within subjects (r = .99); 2) no significant effects of dose on smoking topography; and 3) significant dose effects for whole blood cocaine concentrations, heart rate and systolic blood pressure.
authors.affiliation: Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55455.
authors.forename: D
authors.initials: D
authors.lastname: Hatsukami
authors.forename: R
authors.initials: R
authors.lastname: Keenan
authors.forename: M
authors.initials: M
authors.lastname: Carroll
authors.forename: E
authors.initials: E
authors.lastname: Colon
authors.forename: D
authors.initials: D
authors.lastname: Geiske
authors.forename: B
authors.initials: B
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Huber
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011680:Pupil / Q000187:drug effects; D012907:Smoking / Q000097:blood* / Q000503:physiopathology / Q000523:psychology; D019966:Substance-Related Disorders
chemical_list: D003042:Cocaine