Pentylenetetrazole kindling impairs learning in mice.
Repeated administration of 35 mg/kg body weight pentylenetetrazole (PTZ) induced a kindling phenomenon and an impairment of inhibitory avoidance learning. In contrast, a single administration of the same dose PTZ had no effect on learning. Kindled mice showed impaired habituation of exploratory activity. The results may be of relevance for antiepileptic drug testing.
Voigt
J P
JP
Institute of Pharmacological Research of the Pharmaceutical Industry GERMED, Berlin-Friedrichsfelde, GDR.
Morgenstern
E
E
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010805:Physical Conditioning, Animal
D010433:Pentylenetetrazole