title: Transferrin receptors in injured brain.
abstract: Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells, probably macrophages. Although Tf-R were seen in proliferating cells, Tf-R were also observed in non-proliferating cells, many of them macrophages. The receptors perhaps bind transferrin in edema fluid and play an important role in lesion repair.
authors.affiliation: Department of Neurosurgery, Yamaguchi University School of Medicine, Ube.
authors.forename: T
authors.initials: T
authors.lastname: Orita
authors.forename: T
authors.initials: T
authors.lastname: Akimura
authors.forename: T
authors.initials: T
authors.lastname: Nishizaki
authors.forename: T
authors.initials: T
authors.lastname: Kamiryo
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeyama
authors.forename: H
authors.initials: H
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Ito
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011990:Receptors, Transferrin / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D011990:Receptors, Transferrin