[Oral cyclosporine pharmacokinetics in renal transplantation patients].
Cyclosporine was extracted from whole blood and analyzed by HPLC. The pharmacokinetics of oral cyclosporine were studied in patients with renal transplant. They were 5 women and 3 men between the ages of 29-49 years. Cyclosporine was used for 47 days to 11 months after renal transplantation. The mean dose was 8.26 +/- 1.41 mg/kg.d (5.88-10.0 mg/kg.d), once each 12 hours. Three hundreds whole blood samples were monitored. The peak concentration (Cmax) was 664.9 +/- 87.5 ng/ml; peak time was 3.27 +/- 1.07 h; slow elimination phase t1/2 beta was 13.53 (6.13-43.3) h.
Zhuo
H T
HT
General Hospital of Nanjing Armed Forcer, Nanjing.
Chen
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G
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D003524:Cyclosporins