A-bomb radiation and evidence of late effects other than cancer.
Cancer risk coefficients for ionizing radiation are currently based on the assumption that, after the bombing of Hiroshima and Nagasaki, there were no late effects of early selection (survival of the fittest) or acute marrow damage. These negative findings were the result of applying a linear model of relative risk to the deaths of 5-y survivors. By applying a linear-quadratic model to these deaths (i.e., a model with more than one degree of freedom), we have obtained evidence of longstanding competition between selection effects of the early deaths and other radiation effects, and also evidence that late effects of radiation include marrow damage as well as cancer. Consequently, the present method of risk estimation--by linear extrapolation of high dose effects--should no longer be used for estimating the cancer effects of occupational exposures or background radiation.
Stewart
A M
AM
Health Services Research Centre, University of Birmingham, United Kingdom.
Kneale
G W
GW
D006801:Humans; D007564:Japan; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009689:Nuclear Warfare; D011832:Radiation Injuries / Q000401:mortality*; D016019:Survival Analysis; D013997:Time Factors