Gastroparesis after a presumed viral illness: clinical and laboratory features and natural history.
Gastroparesis after a viral infection has rarely been reported. In this article, we describe the clinical features and long-term outcome of 7 patients who had gastroparesis after a presumed viral illness and who were identified in a retrospective review of 103 consecutive cases of gastroparesis seen at our institution from 1977 through 1988. The three male and four female patients with gastroparesis after a suspected viral illness were young (mean age, 26.9 years) and healthy before the onset of the illness, which manifested as low-grade fever, fatigue, and myalgia with or without diarrhea. A mean of 4.5 days after spontaneous resolution of the viral illness, persistent nausea, vomiting, and epigastric pain developed in these patients. In all seven patients, delayed emptying of the gastric contents was substantiated. Autonomic neuropathy was found in all three patients who underwent autonomic function tests. During a mean follow-up of 32.3 months, five of the seven patients had complete resolution of gastroparetic symptoms, and the other two had considerable improvement of their condition. We conclude that postviral gastroparesis is uncommon, is frequently associated with autonomic dysfunction, and is associated with an apparently excellent prognosis.
Oh
J J
JJ
Division of Gastroenterology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Kim
C H
CH
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010243:Paralysis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011379:Prognosis; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013272:Stomach Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D014777:Virus Diseases / Q000150:complications*