Biological characterization of human monoclonal antibodies to rabies virus.
Rabies virus antigen-specific human monoclonal antibodies (MAbs) that recognized either viral glycoprotein, ribonucleoprotein, or matrix proteins were generated. Only glycoprotein-specific MAb neutralized a variety of rabies viruses and protected laboratory rodents against lethal rabies virus infection. The determinant recognized by this MAb does not appear to reside in previously defined antigenic sites of the viral glycoprotein.
Dietzschold
B
B
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104-4268.
Gore
M
M
Casali
P
P
Ueki
Y
Y
Rupprecht
C E
CE
Notkins
A L
AL
Koprowski
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D009500:Neutralization Tests; D011819:Rabies Vaccines; D011820:Rabies virus / Q000276:immunology*; D012261:Ribonucleoproteins / Q000032:analysis / Q000276:immunology; D014763:Viral Matrix Proteins / Q000032:analysis / Q000276:immunology; D014764:Viral Proteins / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011819:Rabies Vaccines; D012261:Ribonucleoproteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins