Treatment of bacterial vaginosis in women with vaginal bleeding complications or discharge and harboring Mobiluncus.
A double-blind study of treatment for bacterial vaginosis (BV), using metronidazole tablets 500 mg 3 times daily for 10 days versus placebo in the same regimen, was performed on 42 outpatients with irregular bleeding episodes or discharge attending a gynecological clinic. All patients had motile rods in wet smears in addition to fulfilling the criteria for BV. Treatment gave a cure rate of 76% versus 5% in the placebo group. Mobiluncus sp. was identified in 81% of these cases before treatment, in 8% of the cured patients and in 50% of those not initially cured at follow-up. Repeated treatments, once or twice, resulted in a 100% cure rate. A 6-month follow-up was carried out on 39 of the 42 patients. There were 7 relapses after 6 months giving a cure rate of 82%. After successful treatment all bleeding disturbances disappeared. We conclude that it is important to treat BV in patients with symptoms other than malodorous discharge.
Larsson
P G
PG
Department of Obstetrics and Gynecology, Central Hospital, Skövde, Sweden.
Bergman
B
B
Forsum
U
U
Påhlson
C
C
D000328:Adult; D001421:Bacteria, Anaerobic / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007973:Leukorrhea / Q000209:etiology; D008795:Metronidazole / Q000627:therapeutic use*; D014592:Uterine Hemorrhage / Q000209:etiology*; D014627:Vaginitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
D008795:Metronidazole