title: Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor.
abstract: The role of platelet-activating factor (PAF) in the induction of rat gastric mucosal damage by ischemia-reperfusion was examined with reference to hemodynamic characteristics. Gastric mucosal hemodynamics was measured continuously, using laser-Doppler flowmetry and reflectance spectrophotometry. Not only gastric mucosal damage but also characteristic hemodynamic change--that is, ischemia with congestion--was observed in the PAF infusion and reperfusion periods of the ischemia-reperfusion model. CV-6209, a specific PAF antagonist, significantly alleviated gastric mucosal damage and hemodynamic disturbance induced by ischemia-reperfusion. These results strongly suggest that PAF is a potent mediator of gastric mucosal damage during reperfusion in the ischemia-reperfusion model.
authors.affiliation: Third Dept. of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Binnaka
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: J
authors.initials: J
authors.lastname: Hirohara
authors.forename: T
authors.initials: T
authors.lastname: Mizuno
authors.forename: Y
authors.initials: Y
authors.lastname: Sameshima
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000098:blood supply* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D010972:Platelet Activating Factor / Q000502:physiology*; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000503:physiopathology*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C053321:CV 6209