Study of mature cells in human myeloid malignancies by premature chromosome condensation.
The premature chromosome condensation technique allows cytogenetic studies (chromosomes scoring or karyotyping after banding) of mature non cycling cells. In conjunction with cell fractionation, it appears a powerful tool to study spontaneous or therapy-induced maturation of cells of acute myelogenous leukemia or myelodysplastic syndrome patients. It is useful for determining the involvement of multiple lineages in hematopoietic diseases.
Tigaud
J D
JD
Service d'Hématologie Clinique, Pavillon Marcel-Bérard 1F, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
D002875:Chromosomes; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000235:genetics*