title: [Thrombin and anti-thrombin antibody levels in the blood of patients with acute myocardial infarction].
abstract: Simultaneous levels of thrombin and its natural antibodies were comparatively analyzed in donors and patients with myocardial infarction. Thrombin and its antibody levels were demonstrated to remain unchanged in the healthy subjects. With myocardial infarction development, there was an increase in thrombin concentrations and a decrease in natural antithrombin antibodies at the same time. A linear correlation was established between the levels of thrombin and its antibodies and failure in diagnosing coagulative disorders by one of the parameters studied was also ascertained, which made it possible to introduce a new diagnostic criterion, namely an "antithrombin index" that enabled the groups of donors and patients to be differentiated.
authors.forename: I M
authors.initials: IM
authors.lastname: Korochkin
authors.forename: I A
authors.initials: IA
authors.lastname: Verbitskaia
authors.forename: A N
authors.initials: AN
authors.lastname: Tugutov
authors.forename: M A
authors.initials: MA
authors.lastname: Miagkova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Polevaia
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001782:Blood Donors; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000276:immunology; D013917:Thrombin / Q000032:analysis* / Q000276:immunology; D013927:Thrombosis / Q000209:etiology
chemical_list: D001323:Autoantibodies; D013917:Thrombin
vernacular_title: Dinamika soderzhaniia trombina i antitel k nemu v krovi bol'nykh ostrym infarktom miokarda.