[Morphofunctional status of the system of mononuclear phagocytes in rats exposed to the embryotoxic effect of cadmium].
The experiments have been performed on white non-inbred rats, subjected to intragastric injection of cadmium chloride (7.5 mg/kg) during the whole period of pregnancy. Morphological analysis has been performed on the state of the main links in mononuclear phagocytes system (osseous-medullary precursors, monocytes of blood and alveolar macrophages of lungs), using cytological, cytochemical and electron microscopical (scanning electron microscopy) investigation methods. Changes in the cell enzymatic activity, inhibition of adhesiveness and lesion of the superficial architectonics of blood monocytes and pulmonary macrophages have been revealed against the background of their increased phagocyting activity. This demonstrates certain decrease in nonspecific resistivity of the organism, when the embryotoxic effect is developing.
Litvinov
N N
NN
Kazachkov
V I
VI
Gasimova
Z M
ZM
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D007958:Leukocyte Count / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D008431:Maternal-Fetal Exchange / Q000276:immunology; D008855:Microscopy, Electron, Scanning; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D051381:Rats
D002104:Cadmium; D019256:Cadmium Chloride
Morfofunktsional'noe sostoianie sistemy mononuklearnykh fagotsitov krys pri èmbriotoksicheskom vozdeĭstvii kadmiia.