[Tissue distribution of red blood cells treated with X-ray contrast media in rats].
Tissue distribution of red blood cells (RBC) that were treated with X-ray contrast media was investigated in rats. The contrast medium mixed with an equivolume of 51Cr-labelled RBC was administered to the internal carotid artery in a dose of 200 microliters/rat; and the radioactivity in the brain, lung and spleen were determined. The contrast medium mixed with an equivolume of blood was administered to the right atrium in a dose of 4 ml/kg, and the hemoglobin content in the lung and changes in pulmonary and circulatory functions were determined. In the ionic contrast medium (meglumine diatrizoate)-treated group, the radioactivity in the brain remained 30 to 50 times higher compared with the nonionic contrast medium (iopamidol)- and saline-treated group until 15 min after infusion. The radioactivity in the spleen increased and the radioactivity and hemoglobin content in the lung decreased time-dependently in the diatrizoate-treated group, whereas iopamidol- and saline-treated groups exhibited constantly low values during the experimental period. Changes in the airway pressure, pulmonary arterial pressure, systemic blood pressure and heart rate were similar after intra-atrial administration of diatrizoate mixed with blood and diatrizoate mixed with saline. These results suggest that the ionic contrast medium affects the RBC and causes a microcirculatory disturbance in the brain.
Miyazawa
T
T
Department of Pharmacology, Research Laboratories, Osaka, Japan.
Arita
S
S
Shou
C
C
Nakagawa
H
H
Oshino
N
N
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D003287:Contrast Media / Q000009:adverse effects / Q000493:pharmacokinetics*; D003974:Diatrizoate Meglumine / Q000009:adverse effects / Q000493:pharmacokinetics; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D007479:Iopamidol / Q000009:adverse effects / Q000493:pharmacokinetics; D008168:Lung / Q000378:metabolism; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D003287:Contrast Media; D006454:Hemoglobins; D003974:Diatrizoate Meglumine; D007479:Iopamidol