title: [Disease-specific and non-specific seasonal parameter changes in hayfever patients].
abstract: 10 patients have been treated by subcutaneous injections of placebo three times weekly for 4 weeks within a phase-I trial of BCH-069. Immunological, hematological and biochemical parameters were observed at different times: preseasonal, seasonal and postseasonal. --Some new observations are reported, which are induced by the seasonal inflammation. For example there was a strong increase of C-reactive protein and also an increase in the triglyceride level. --The parameters could be useful for trials of new antiallergic drugs in hay fever in the future.
authors.affiliation: Institut für Klinische Immunologie, Friedrich-Schiller-Universität Jena.
authors.forename: H U
authors.initials: HU
authors.lastname: Simon
authors.forename: G
authors.initials: G
authors.lastname: Metzner
authors.forename: E
authors.initials: E
authors.lastname: Keil
authors.forename: C
authors.initials: C
authors.lastname: Piesch
authors.forename: G
authors.initials: G
authors.lastname: Schlenvoigt
authors.forename: H
authors.initials: H
authors.lastname: Storz
authors.forename: L
authors.initials: L
authors.lastname: Jäger
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001798:Blood Proteins / Q000032:analysis; D001985:Bronchial Provocation Tests; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007167:Immunotherapy; D008077:Lipoproteins, LDL / Q000032:analysis; D009842:Oligopeptides / Q000627:therapeutic use; D010446:Peptide Fragments / Q000627:therapeutic use; D010991:Plethysmography; D011058:Pollen / Q000032:analysis / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology* / Q000628:therapy; D012621:Seasons; D014280:Triglycerides / Q000097:blood
chemical_list: D000276:Adjuvants, Immunologic; C064311:BCH 069; D001798:Blood Proteins; D007136:Immunoglobulins; D008077:Lipoproteins, LDL; D009842:Oligopeptides; D010446:Peptide Fragments; D014280:Triglycerides; D002097:C-Reactive Protein
vernacular_title: Krankheitsspezifische und -unspezifische saisonale Parameterveränderungen bei Pollinosepatienten.