The effect of guanethidine treatment of testicular blood flow and testosterone production in rats.
Testicular blood flow was measured by means of Xenon-133 clearance in control rats and rats treated with guanethidine for 3 weeks. Plasma and testis testosterone concentrations were also measured, and the effect of hCG-treatment was examined. No difference in testicular blood flow between the control group and the guanethidine-treated group was found. However, in guanethidine-treated rats, plasma and testis testosterone concentrations after hCG-treatment were significantly decreased. The results may indicate that adrenergic nerves are involved in the regulation of Leydig cell function.
Damber
J E
JE
Department of Urology and Andrology, University of Umeå, Sweden.
D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology; D000818:Animals; D006063:Chorionic Gonadotropin; D006145:Guanethidine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013737:Testis / Q000098:blood supply* / Q000294:innervation / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis* / Q000097:blood; D014980:Xenon Radioisotopes
D006063:Chorionic Gonadotropin; D014980:Xenon Radioisotopes; D013739:Testosterone; D006145:Guanethidine