Local administration of cyclosporin allows reduction of the dose prolonging survival of heart tissue allografts.
In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts.
Górecki
D
D
Department of Histology and Embryology, Medical School, Warsaw, Poland.
Kruszewski
A
A
Jakóbisiak
M
M
Lasek
W
W
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage*; D004431:Ear, External; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D003524:Cyclosporins