Effect on thrombus growth and thrombolysis of two types of osmolar contrast media in rabbits.
Thromboembolic complications have been reported after diagnostic or interventional radiological procedures. However, contrast media inhibit platelet function and blood coagulation in vitro. To investigate these characteristics in vivo, we determined the effect of nonionic and ionic low osmolar contrast media on thrombus growth and thrombolysis in rabbits in a randomized study design. Rabbits received either ionic low osmolar contrast medium (ioxaglate), nonionic low osmolar contrast medium (iohexol) or saline. Thrombus growth was determined by the accretion of 125I-labeled fibrinogen on to autologous, nonradioactive, preformed thrombi in rabbit jugular veins. Thrombolysis was assessed by measurement of the decrease in radioactivity of standard sized preformed 125I-fibrinogen labeled thrombi. Ioxaglate significantly inhibited thrombus growth (60% inhibition, P less than 0.005 vs. saline), in contrast to iohexol, which had no significant effect (33% inhibition, P less than 0.2 vs. saline). Neither ioxaglate nor iohexol affected thrombolysis.
Levi
M
M
Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands.
Pascucci
C
C
Agnelli
G
G
Sturk
A
A
Hoek
J
J
Wouter ten Cate
J
J
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007472:Iohexol / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007485:Ioxaglic Acid / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D009994:Osmolar Concentration; D011817:Rabbits; D013268:Stimulation, Chemical; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy / Q000503:physiopathology*
D003287:Contrast Media; D007472:Iohexol; D007485:Ioxaglic Acid