[Structural and functional state of the renal transplant after spontaneous and surgical restoration of the lymph outflow pathways].
In 62 dogs, presenting a model of the renal autotransplantation into the pelvis on the iliac vessels, a comparative estimation of morpho-functional state of the transplanted organ has been performed at a spontaneous (control) and surgical (experiment) restoration of the lymphatic outflow pathways during the postoperative period from 1 day up to 6 years. Three periods of morpho-functional restoration of the transplant renal tissue have been revealed: I (period of decreased functional activity) lasts in the control from 1 up to 14 days, in the experiment--up to 7 days after the operation; II (period of restoration of the functional activity) lasts in the control from 14 up to 90 days, in the experiment--from 7 up to 30 days after the operation; III (steady functioning of the renal transplant) begins in the control on the 90th day, in the experiment--on the 30th day after the operation and lasts up to the end of the observations. Such signs as lymphostasis and certain disturbances of oxidation-reduction and physical-chemical processes in the renal tissue are specific features. Time of normalization of the processes mentioned and degree of their manifestation depend on spontaneous or surgical restoration of the lymphatic outflow pathways. The surgical relymphatization of the renal transplant contributes to a more rapid and complete restoration of its morphofunctional state in comparison to a traditional method of the kidney transplantation.
Lazarev
K L
KL
Kolbasin
P N
PN
Shpak
S I
SI
D000818:Animals; D004285:Dogs; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology*; D008196:Lymph / Q000502:physiology; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery*; D008220:Lymphography; D013997:Time Factors; D014182:Transplantation, Autologous
Strukturno-funktsional'noe sostoianie pochechnogo autotransplantata pri spontannom i khirurgicheskom vosstanovlenii puteĭ limfoottoka.