title: Gamete intra-fallopian transfer in non-endometriotic pelvic adhesions.
abstract: This report presents our experience with gamete intra-Fallopian transfer (GIFT) in cases with non-endometriotic pelvic adhesions. Two-hundred-and-eight GIFT attempts, where pelvic adhesions were identified laparoscopically in patients with no previous history of endometriosis, were subdivided into two groups: (i) post-surgical (n = 134) and (ii) non-surgical (n = 74). The extent of the adhesions was further classified according to the American Fertility Society (AFS) classification system. The overall clinical pregnancy rate was 39.4% (82 out of 208 attempts). There was no significant difference in the clinical pregnancy rate per attempt between the surgical (38.8%) and the non-surgical (40.5%) groups. A gradual, but not significant decline in the pregnancy rate was noticed from adhesion Stages I to III, but Stage IV had a significantly lower pregnancy rate (22.7%) than Stage I (47.4%). The intra-uterine pregnancy rate was observed to be higher, but not significantly, in the non-surgical (37.8%) than in the surgical (29.1%) cases. The overall ectopic pregnancy rate was 7.2% per attempt and 18.3% per clinical pregnancy. In the post-surgical group, the ectopic pregnancy rate per pregnancy was 3.5 times that in the non-surgical (23.2% versus 6.5%, respectively), and it was significantly higher in Stage IV (40%; two out of five pregnancies) than in Stage I adhesions (11.1%; three out of 27 pregnancies). In cases with a history of tubal surgery, the ectopic pregnancy rate was 33.3% (10 out of 30 pregnancies). Our results indicate that GIFT can offer a successful treatment option for selected cases with non-endometriotic pelvic adhesions.
authors.affiliation: Fertility and IVF Unit, Humana Hospital Wellington, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: al-Shawaf
authors.forename: M
authors.initials: M
authors.lastname: Ah-Moye
authors.forename: W
authors.initials: W
authors.lastname: Fiamanya
authors.forename: B
authors.initials: B
authors.lastname: Smith
authors.forename: I
authors.initials: I
authors.lastname: Craft
mesh_terms: D000328:Adult; D005184:Fallopian Tube Diseases / Q000601:surgery; D005260:Female; D015181:Gamete Intrafallopian Transfer / Q000009:adverse effects; D006801:Humans; D010049:Ovarian Diseases; D011183:Postoperative Complications; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000209:etiology; D000267:Tissue Adhesions