title: Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies.
abstract: Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.
authors.affiliation: Department of Ophthalmology, University of Florida, Gainesville 32610-0284.
authors.forename: J
authors.initials: J
authors.lastname: Guy
authors.forename: A
authors.initials: A
authors.lastname: Mancuso
authors.forename: R G
authors.initials: RG
authors.lastname: Quisling
authors.forename: R
authors.initials: R
authors.lastname: Beck
authors.forename: M
authors.initials: M
authors.lastname: Moster
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D009902:Optic Neuritis / Q000175:diagnosis*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011878:Radiotherapy / Q000009:adverse effects; D014792:Visual Acuity
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA