title: Porcine collagen corneal shield treatment of persistent epithelial defects following penetrating keratoplasty.
abstract: Treatment of persistent epithelial defects following penetrating keratoplasty (PK) can be difficult. The use of a 24-hour porcine collagen corneal shield (Bausch & Lomb) to promote epithelialization of these cases was compared to the use of the hydrophilic bandage soft contact lens (Bausch & Lomb, plano O4). Twenty-three consecutive patients treated for persistent epithelial defect following PK were reviewed. Sixteen of 22 (73%) treated with a bandage soft contact lens healed completely. None of seven patients with persistent epithelial defect treated with collagen shield therapy healed. Six of these seven patients were subsequently treated with a bandage soft contact lens; five (83%) healed with this therapy. These data suggest that the 24 hour collagen corneal shield is not useful in treating persistent epithelial defect following PK and that a bandage soft contact lens is significantly more effective (P less than 0.01) in these cases.
authors.affiliation: Department of Ophthalmology, University of South Florida, Tampa 33612-9400.
authors.forename: L R
authors.initials: LR
authors.lastname: Groden
authors.forename: W
authors.initials: W
authors.lastname: White
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001458:Bandages; D001684:Biological Dressings; D003094:Collagen / Q000627:therapeutic use*; D003263:Contact Lenses, Hydrophilic; D003316:Corneal Diseases / Q000209:etiology / Q000628:therapy*; D004848:Epithelium; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013552:Swine; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003094:Collagen