In vivo model systems for assessing an anti-cancer drug: responses of autochthonous and transplanted prostate tumors to cyclophosphamide.
Therapeutic effects of cyclophosphamide (CPA) were compared in L-W rats with (a) transplanted prostate adenocarcinomas (PAs), and (b) with induced autochthonous PAs. All rats, except controls, were treated by IP-administered CPA in slow-release silastic membranes (a) at time 0 after inoculation of transplanted PA cells; or (b) after development of palpable transplanted PAs thereof; or (c) after detection of palpable autochthonous PAs. The treated rats did not manifest evidence of CPA-related toxicity. The transplanted PAs and lung metastases thereof were suppressed by CPA; but, the same treatment schedule with CPA failed to modify continued growth of the autochthonous PAs. This report serves to emphasize the need for test systems of autochthonous model tumors of the counterpart disease in humans.
Pollard
M
M
University of Notre Dame, IN 46556.
Luckert
P H
PH
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D003520:Cyclophosphamide