Preliminary clinical study of transferrin-adriamycin conjugate for drug delivery to acute leukemia patients.
Seven patients with acute leukemia were treated intravenously with low doses of transferrin-Adriamycin conjugate. The total amount of drug given each patient was far below known toxicity levels for free Adriamycin. The number of tumor cells in peripheral blood diminished in treated patients, and bone marrow aspirates showed no evidence of disease progression. Two patients gave a febrile response and no hypersensitivity reactions were observed. Results of parallel basic research have shown that transferrin receptors on acute leukemia cells bind transferrin-Adriamycin conjugates, and kill by mechanisms at either the plasma membrane or nuclear levels, or both. Such conjugates may provide an alternative to monoclonal antibody drug targeting.
Faulk
W P
WP
Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Indianapolis 46202.
Taylor
C G
CG
Yeh
C J
CJ
McIntyre
J A
JA
D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers; D004341:Drug Evaluation; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D007958:Leukocyte Count; D011990:Receptors, Transferrin / Q000378:metabolism; D014168:Transferrin / Q000008:administration & dosage*
D004337:Drug Carriers; D011990:Receptors, Transferrin; D014168:Transferrin; D004317:Doxorubicin