[Study of oleandomycin extraction in a methylene chloride-aqueous medium system].
Influence of pH, temperature and oleandomycin concentration on distribution of the antibiotic in the methylene chloride-aqueous medium system was studied. It was shown that the oleandomycin distribution coefficient did not depend on the antibiotic concentration within the ranges of 2000 to 20,000 micrograms/ml. An equation defining relationship between the oleandomycin distribution coefficient and pH of the aqueous phase is presented.
Slavin
A A
AA
Orlievskaia
O V
OV
Velichko
L S
LS
Reshetov
V A
VA
Komarov
E V
EV
Fradkova
T A
TA
D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008752:Methylene Chloride / Q000494:pharmacology*; D009827:Oleandomycin / Q000302:isolation & purification*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013696:Temperature; D014867:Water / Q000494:pharmacology
D006843:Hydrocarbons, Chlorinated; D014867:Water; D008752:Methylene Chloride; D009827:Oleandomycin
Izuchenie ekstraktsii oleandomitsina v sisteme khloristyĭ metilen-vodnaia sreda.