Structures of paralytic acylpolyamines from the spider Agelenopsis aperta.
The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties.
Quistad
G B
GB
Sandoz Crop Protection Corporation, Palo Alto, California 94304.
Suwanrumpha
S
S
Jarema
M A
MA
Shapiro
M J
MJ
Skinner
W S
WS
Jamieson
G C
GC
Lui
A
A
Fu
E W
EW
D000818:Animals; D001180:Arthropod Venoms / Q000032:analysis*; D006898:Hydroxylamines / Q000032:analysis* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010243:Paralysis / Q000139:chemically induced; D011073:Polyamines / Q000032:analysis* / Q000633:toxicity; D013111:Spider Venoms / Q000032:analysis* / Q000633:toxicity
D001180:Arthropod Venoms; D006898:Hydroxylamines; D011073:Polyamines; D013111:Spider Venoms