[Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors].
An AIDS patient with cerebral toxoplasmosis had a folate deficiency-induced acute pancytopenia, which was rapidly reversed by the administration of folic acid. This observation is particularly important as a possible preventive therapy to be given to all HIV-infected patients because of the anti-folic activity of the majority of anti-infectious agents used during the course of this disease and the many potential sites of hematopoietic involvement. The patient's condition is stressed because the undernourished subject is at greater risk for this type of manifestation.
Boudes
P
P
Département d'Enseignement et de Recherches en Immunologie, Hôpital Henri-Mondor, Créteil.
Zittoun
J
J
Sobel
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000208:Acute Disease; D000328:Adult; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology*; D005493:Folic Acid Antagonists; D005494:Folic Acid Deficiency / Q000139:chemically induced; D015497:HIV-1; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced* / Q000188:drug therapy; D011739:Pyrimethamine / Q000009:adverse effects* / Q000494:pharmacology; D014123:Toxoplasmosis / Q000188:drug therapy / Q000209:etiology*
D005493:Folic Acid Antagonists; D002955:Leucovorin; D011739:Pyrimethamine
Pancytopénie aiguë induite par la pyriméthamine au cours du traitement d'une toxoplasmose cérébrale en rapport avec le SIDA. Rôle des inhibiteurs de la dihydrofolate réductase.