title: Treatment of sickle cell leg ulcers with pentoxifylline.
abstract: A 58-year-old black man with leg ulcers of 43 years duration responded to pentoxifylline 400 mg tid in 8 months. The ability of pentoxifylline to increase erythrocyte flexibility and decrease blood viscosity was the basis for our use of this agent. Oral pentoxifylline may be a useful adjunct in healing sickle cell leg ulcers and preventing their recurrence.
authors.affiliation: Department of Dermatology, Indiana University Medical Center, Indianapolis.
authors.forename: M L
authors.initials: ML
authors.lastname: Frost
authors.forename: P
authors.initials: P
authors.lastname: Treadwell
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012008:Recurrence; D013805:Theobromine / Q000031:analogs & derivatives*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D013805:Theobromine; D010431:Pentoxifylline