Depletion of myocardial high energy phosphates by induction of ventricular fibrillation prior to cardioplegic arrest.
The effects of a short period of ventricular fibrillation on myocardial high energy phosphates were assessed in two groups of rats. Group 1 underwent hypothermic crystalloid cardioplegia infusion and aortic cross-clamping. In Group 2, cardioplegia and cross-clamping were preceded by ten seconds of induced ventricular fibrillation. In rat hearts that had undergone ventricular fibrillation, adenosine triphosphate levels averaged only 70% (p less than .0001) and creatine phosphate levels averaged only 60% (p less than .0005) of levels measured following standard cardioplegic arrest without ventricular fibrillation. These findings are of potential importance in both routine cardiac surgical procedures and in organ procurement.
Levett
J M
JM
Department of Surgery, University of Chicago Hospitals, Illinois.
Kadowaki
M H
MH
Ip
J H
JH
Karp
R B
RB
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D006324:Heart Arrest, Induced; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014693:Ventricular Fibrillation / Q000378:metabolism*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate