[Prevention with inderal of post-resuscitation impairment of metabolism in heart and brain tissues].
Restriction of lipolysis as well as a decrease in the rate of lipid peroxidation due to prevention of inhibition of antioxidant enzymes and to maintaining of bioantioxidants in heart and brain tissues were observed during the postresuscitation period in rats preadministered with inderal and reanimated after acute lethal hemorrhage. Inderal, which maintained homeostasis of phospholipid fractions in cardiomyocyte membranes, decreased the electric unstability of heart and prevented the ventricles fibrillation within the early period after resuscitation. The drug decreased distinctly catabolism of adenylic nucleotides in heart and brain tissues.
Dolgikh
V T
VT
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*
D002395:Catecholamines; D011433:Propranolol
Predotvrashchenie inderalom postreanimatsionnykh narusheniĭ metabolizma v tkaniakh serdtsa i mozga.