[The possibility of predicting the antinociceptive effect of dalargin in the preoperative period].
The antinociceptive effect of dalargin was studied by its influence on the amplitude of somatosensory induced potentials (IP) and by changes in the threshold pain sensitivity to heat stimulation. It was shown that it was necessary to taken into account the patients' individual sensitivity to the drug. The influence of dalargin on IP in the pre-operative period was compared with the quality of its analgetic defence in surgical interventions. The defence quality was determined according to the reduction in the consumption of the narcotic analgesic phentanyl during anesthesia. The studied parameters were found to be directly related to the correlation coefficient 0.75 (p less than 0.05). The findings allow for a reliable prediction of the antinociceptive effect of dalargin in its application in anaesthesiological practice.
Petrov
O V
OV
Bikmulina
F S
FS
Vinogradov
V L
VL
Fomchenko
E P
EP
Smol'nikov
P V
PV
Shloznikov
B M
BM
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D011229:Preanesthetic Medication; D012684:Sensory Thresholds / Q000187:drug effects
D000700:Analgesics; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vozmozhnost' prognozirovaniia antinotsitseptivnogo éffekta dalargina vpredoperatsionnom periode.