title: Risk factors related to biological behaviour of precancerous lesions of the uterine cervix.
abstract: In a study of factors related to cervical carcinogenesis, a cohort of 1,107 cervical dysplasia along with 1,077 controls matched for age and parity were followed up prospectively. During the follow up 75 dysplasia cases progressed to carcinoma in situ. The overall rate of progression of dysplasia to malignancy was observed to be 15.7% at the end of 108 months of follow-up. The analysis of progression rates in relation to various factors revealed significantly higher progression rates for initially higher grade of dysplastic lesions, and early age at consummation of marriage (ACM). The other factors, such as religion, literacy status of the patient, number of pregnancies, presence of cervical erosion, history of fetal loss and positivity to HSV-II antibodies, did not reveal statistical significance. The case-control comparison for detection of HPV 16/18 by in situ hybridisation revealed the presence of HPV 16/18 sequences in 67.3% of the dysplasia subjects progressed to carcinoma in situ while 27.3% of precancerous cases regressed to normalcy. The difference was found to be statistically significant (P less than 0.001).
authors.affiliation: Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, New Delhi, India.
authors.forename: N S
authors.initials: NS
authors.lastname: Murthy
authors.forename: A
authors.initials: A
authors.lastname: Sehgal
authors.forename: L
authors.initials: L
authors.lastname: Satyanarayana
authors.forename: D K
authors.initials: DK
authors.lastname: Das
authors.forename: V
authors.initials: V
authors.lastname: Singh
authors.forename: B C
authors.initials: BC
authors.lastname: Das
authors.forename: M M
authors.initials: MM
authors.lastname: Gupta
authors.forename: A B
authors.initials: AB
authors.lastname: Mitra
authors.forename: U K
authors.initials: UK
authors.lastname: Luthra
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008393:Marriage; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology*