title: [Neurosarcoidosis].
abstract: It is easy to identify patients with neurosarcoidosis who have a lesion the neural lesion. However, it is be difficult if the patient has a preceding neural lesion or isolated CNS sarcoidosis in which the lesion is localized in CNS and the lesion in another organ hem regressed. The finding of generalized or localized cerebral edema and the shadow of tumor on CT, and the result of CSF examination which indicates an increase in cell count, protein or ACE activity (especially in meningitis type) are helpful for the diagnosis of the above disorder. Epidemiological studies on the basis of 21 patients with neurosarcoidosis in our center and 166 patients in our country indicated that this disorder was more common in females than in males (1.6/1). The age of patients showed predominance in the twenties in males, and the twenties, forties and fifties in females. Common pathological finding in our postmortem examinations (n = 2) and intracranial biopsy (n = 1) was lymphocytic phlebitis in central and peripheral neurons and in neurons with no clinical symptom.
authors.affiliation: Department of Respiratory Disease, Japanese Red Cross Medical Center.
authors.forename: M
authors.initials: M
authors.lastname: Oritsu
authors.forename: M
authors.initials: M
authors.lastname: Sakuta
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis / Q000473:pathology; D012737:Sex Factors