title: Influence of hydrophobicity on the ion exchange selectivity coefficients for aromatic amines.
abstract: Hydrophobic effects could play an important role in determining the selectivity of organic ions for ion-exchange resins in aqueous solutions. We used the octanol-water partition coefficient (P) and the chromatographic capacity factor (K') as indices of hydrophobicity of a series of primary and secondary amines, and examined their relationships with the amine selectivity coefficient (K) in binding to the Amberlite IRP-69 ion-exchange resin. Good correlations were found between log K versus log P and log K versus log K', but the relationship appears to be dependent on the degree of substitution at the amino nitrogen. These relationships may be useful for the estimation of selectivity coefficients of various amine drug candidates when they are considered for incorporation with ion-exchange resins in potential controlled-release systems.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo 14260.
authors.forename: M B
authors.initials: MB
authors.lastname: Kril
authors.forename: H L
authors.initials: HL
authors.lastname: Fung
mesh_terms: D000588:Amines; D007474:Ion Exchange; D007475:Ion Exchange Resins
chemical_list: D000588:Amines; D007475:Ion Exchange Resins