Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor.
The role of platelet-activating factor (PAF) in the induction of rat gastric mucosal damage by ischemia-reperfusion was examined with reference to hemodynamic characteristics. Gastric mucosal hemodynamics was measured continuously, using laser-Doppler flowmetry and reflectance spectrophotometry. Not only gastric mucosal damage but also characteristic hemodynamic change--that is, ischemia with congestion--was observed in the PAF infusion and reperfusion periods of the ischemia-reperfusion model. CV-6209, a specific PAF antagonist, significantly alleviated gastric mucosal damage and hemodynamic disturbance induced by ischemia-reperfusion. These results strongly suggest that PAF is a potent mediator of gastric mucosal damage during reperfusion in the ischemia-reperfusion model.
Binnaka
T
T
Third Dept. of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yamaguchi
T
T
Kubota
Y
Y
Hirohara
J
J
Mizuno
T
T
Sameshima
Y
Y
D000818:Animals; D005753:Gastric Mucosa / Q000098:blood supply* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D010972:Platelet Activating Factor / Q000502:physiology*; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000503:physiopathology*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013997:Time Factors
D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; C053321:CV 6209