title: Anticholinergic pre-treatment in rigid bronchoscopy. Effect on heart rate, arterial blood pressure and cardiac arrhythmias.
abstract: The effect of anticholinergic pre-treatment on the hemodynamic changes during rigid bronchoscopy was studied. Eighty four adult patients in three groups received intravenous saline (control), atropine or glycopyrrolate several minutes before anesthesia and venturi ventilation with intermittent thiopentone and suxamethonium. The rises in heart rate and blood pressure and the incidence of cardiac dysrhythmias were least in the control group. Transient bradycardia rarely occurred, even in the control group, despite repeat doses of suxamethonium. Although most of the results were not statistically significant, they suggest that preoperative anticholinergic administration may aggravate some of the cardiovascular effects of bronchoscopy resulting from sympathoadrenal stimulation.
authors.affiliation: Department of Anesthesia, Broadgreen Hospital, Liverpool.
authors.forename: M A
authors.initials: MA
authors.lastname: Lyew
authors.forename: S P
authors.initials: SP
authors.lastname: Behl
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001999:Bronchoscopy / Q000009:adverse effects / Q000379:methods*; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010276:Parasympatholytics / Q000494:pharmacology*; D011229:Preanesthetic Medication; D011759:Pyrrolidines / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D010276:Parasympatholytics; D011759:Pyrrolidines; D001285:Atropine; D006024:Glycopyrrolate