title: Optic neuritis: a prospective study.
abstract: We studied 20 patients with acute optic neuritis prospectively for 12 months. Visual fields, color vision, and VEPs to 15' checks were initially abnormal in all patients. Visual acuity was abnormal in 90% and contrast sensitivity in 95% of patients. We devised a graded visual impairment scale (GVIS) to include all visual functions tested. Complete recovery of visual function occurred in 65% of cases. Recovery in the majority of patients was rapid and complete within the first 2 months. In some patients, improvement continued over 6 months. The initial classification on the GVIS was significantly correlated with the final outcome. Patients initially classified as having moderate visual impairment recovered completely or improved to near normal vision. Sixty percent of patients initially classified as total or severe blindness had permanent visual impairment. VEP latency remained prolonged in 19 patients, even when their vision had returned to normal, and is a reliable indicator of resolved optic neuritis.
authors.affiliation: Department of Neurology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL 60153.
authors.forename: G G
authors.initials: GG
authors.lastname: Celesia
authors.forename: D I
authors.initials: DI
authors.lastname: Kaufman
authors.forename: M
authors.initials: M
authors.lastname: Brigell
authors.forename: S
authors.initials: S
authors.lastname: Toleikis
authors.forename: D
authors.initials: D
authors.lastname: Kokinakis
authors.forename: R
authors.initials: R
authors.lastname: Lorance
authors.forename: B
authors.initials: B
authors.lastname: Lizano
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000150:complications / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology; D014787:Vision Tests; D015349:Vision, Monocular; D014792:Visual Acuity