title: Hodgkin's disease in patients with antibodies to human immunodeficiency virus. A study of 22 patients.
abstract: The experience of 22 Hodgkin's disease (HD) patients with human immunodeficiency virus type I (HIV) antibodies, collected from a cooperative study of six hospitals during 1984-1989 is presented. Young men (average age, 27.6 years) with a high incidence of intravenous drug abuse (86%) were found. The status of the HIV infection at diagnosis of HD was: four patients, acquired immune deficiency syndrome (AIDS); eight patients, persistent generalized lymphadenopathy (PGL); and ten patients, asymptomatic. The natural history of HD was unusual, with a high incidence of B symptoms (81%), advanced Stages III to IV (90%), bone marrow invasion (50%), cytopenias before treatment (45%), opportunistic infections (68%), and aggressive histologies. A decreased response to chemotherapy with poor marrow tolerance and a significant decrease in survival, 18 months, was observed. The AIDS and cytopenias pretreatment were associated with a shorter statistically significant survival, which defines the importance of immunodeficiency in HD prognosis. Complete remission after treatment was a factor that contributed to a longer statistically significant survival. The PGL or asymptomatic patients survived longer but also had a poor course, and five of them had AIDS criteria during evolution. A high incidence of HD in relation to non-Hodgkin's lymphoma (NHL) in patients with HIV infection in the six cooperating hospitals was found. Criteria for considering HD as an AIDS-associated lymphoproliferative disease in our environment are discussed.
authors.affiliation: Hospital Ramón y Cajal, Alcalá de Henares University, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Serrano
authors.forename: C
authors.initials: C
authors.lastname: Bellas
authors.forename: E
authors.initials: E
authors.lastname: Campo
authors.forename: J
authors.initials: J
authors.lastname: Ribera
authors.forename: C
authors.initials: C
authors.lastname: Martín
authors.forename: R
authors.initials: R
authors.lastname: Rubio
authors.forename: C
authors.initials: C
authors.lastname: Ruiz
authors.forename: I
authors.initials: I
authors.lastname: Ocaña
authors.forename: L
authors.initials: L
authors.lastname: Buzón
authors.forename: M
authors.initials: M
authors.lastname: Yebra
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000401:mortality; D000328:Adult; D003131:Combined Modality Therapy; D015658:HIV Infections / Q000150:complications* / Q000401:mortality; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009894:Opportunistic Infections / Q000453:epidemiology / Q000401:mortality; D012074:Remission Induction; D015996:Survival Rate