Effect of exogenous hydrogen peroxide on human erythrocytes.
Circulating erythrocytes are drastically susceptible to peroxidative reactions. To examine the extent of the damage induced by exogenous H2O2 we limited the catalase activity in order to study the extent of lysis, the lipid peroxidation and namely the behaviour of membrane micro-viscosity. Our data showed that the erythrocytes can efficiently scavenge exogenous H2O2 without significant damage of the cells and/or their membranes. These findings could confirm the important role of the erythrocytes as extracellular-antioxidant defense.
Tozzi-Ciancarelli
M G
MG
Dept. of Biomedical Sciences, School of Medicine, University of L'Aquila.
Di Massimo
C
C
D'Orazio
M C
MC
Mascioli
A
A
Di Giulio
A
A
Tozzi
E
E
D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D014783:Viscosity
D006861:Hydrogen Peroxide