HLA antigens in multiple sclerosis of northern Spanish population.
HLA-A, -B, -C, -DR, -DQ antigens were studied in 43 multiple sclerosis (MS) patients with clinically definite remittent sclerosis from Asturias (North Spain). The prevalence of HLA-B7, B7 and B27 were significantly increased in MS. HLA-B35 was under-represented in these patients. DR2 was increased but not significantly. No association with DQw1 was discovered. The existence of several susceptibility factors in the more common B7/DR2/DQw1 haplotype is discussed.
López-Larrea
C
C
Inmunología, Hospital NS Covadonga, Oviedo, Spain.
Uría
D F
DF
Coto
E
E
D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D015802:HLA-DR2 Antigen / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D013030:Spain
D006680:HLA Antigens; D015235:HLA-B Antigens; D015802:HLA-DR2 Antigen