title: Chronic beta-carotene supplementation does not alter the gastric mucosal response to acute aspirin ingestion.
abstract: Carotenoids and retinoids have been reported to reduce gastrointestinal mucosa damage from a variety of irritants. We performed double-blind, placebo-controlled endoscopic trial to evaluate the effect of chronic beta-carotene supplementation upon the gastric mucosal response to acute aspirin injury. Six subjects taking chronic beta-carotene and six taking placebo each ingested 650 mg of aspirin after an endoscopy confirmed normal gastric mucosa. Three hours later, mucosal lesions were counted at repeat endoscopy. beta-Carotene did not prevent acute mucosal injury better than placebo.
authors.affiliation: Gastroenterology Service, Walter Reed Army Medical Center, Washington, D.C. 20307-5001.
authors.forename: F M
authors.initials: FM
authors.lastname: Moses
authors.forename: J W
authors.initials: JW
authors.lastname: Kikendall
authors.forename: P
authors.initials: P
authors.lastname: Bowen
authors.forename: T R
authors.initials: TR
authors.lastname: Young
mesh_terms: D000208:Acute Disease; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000517:prevention & control; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D002338:Carotenoids; D001241:Aspirin