[Regulating properties of peptides of the thymus and bursa of Fabricius in immunodepression in birds].
The intensity of nucleic acids and protein synthesis in the cells of the thymus and the bursa of Fabricius was studied in chickens against the background of an immunodepression induced by administration of hydrocortisone and cyclophosphamide. It was found out that hydrocortisone causes in chicken a marked lowering of the intensity of inclusion of 3H-thymidine, 3H-uridine and 14C-glycine in thymic cells, and cyclophosphamide--in the cells of the bursa of Fabricius. Under the conditions of selective immunodepression the preparations on the basis of the peptides of the thymus (thymalin) and of the bursa of Fabricius (bursilin) regulate the processes of nucleic acids and protein synthesis chiefly in the cells of organs which produce them.
Sukhinina
T L
TL
Pridybaĭlo
N D
ND
Morozov
V G
VG
Khavinson
V Kh
VKh
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002060:Bursa of Fabricius / Q000276:immunology* / Q000378:metabolism; D002645:Chickens; D003520:Cyclophosphamide / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D007165:Immunosuppression Therapy; D009696:Nucleic Acids / Q000096:biosynthesis; D014176:Protein Biosynthesis; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism; D013951:Thymus Hormones / Q000276:immunology*
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D013951:Thymus Hormones; C032805:thymalin; D003520:Cyclophosphamide; D006854:Hydrocortisone
Reguliruiushchie svoĭstva peptidov timusa i bursy Fabritsiusa pri immunodepressii u ptits.