Different effects of atropine and cimetropium bromide on gastric emptying of liquids and antroduodenal motor activity in man.
Atropine (1 mg intravenously) and a new antimuscarinic compound, cimetropium bromide (5 mg intravenously), as well as placebo (physiological saline) were tested for their effects on gastric emptying and antroduodenal motility in healthy humans. In a first single-blind cross-over study, the emptying rate was assessed in 12 subjects by measuring paracetamol absorption. In a second single-blind parallel-group study, antroduodenal motor activity was measured in 20 subjects through four perfused open tip catheters with orifices positioned in the antroduodenal region. Atropine, unlike cimetropium bromide, significantly delayed gastric emptying. Antral and duodenal motility index was reduced significantly by atropine, but not by cimetropium bromide. Heart rate significantly increased only after atropine. Three subjects taking atropine complained of dry mouth and one of blurred vision. In conclusion, the results of these studies show that atropine, unlike cimetropium bromide, strongly inhibits gastric emptying of liquids and reduces antroduodenal motor activity in man.
Imbimbo
B P
BP
Medical Department, Boehringer Ingelheim Italy, Milan.
Gardino
L
L
Palmas
F
F
Frascio
M
M
Canepa
G
G
Scarpignato
C
C
D000328:Adult; D001285:Atropine / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000097:blood / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D012602:Scopolamine Derivatives / Q000097:blood / Q000494:pharmacology*; D016037:Single-Blind Method
D010276:Parasympatholytics; D012602:Scopolamine Derivatives; C016859:cimetropium; D001285:Atropine