title: Routine production of 2-deoxy-2-[18F]fluoro-D-glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.
abstract: Resin-supported [18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [18F]FDG. "No-carrier-added" [18F]fluoride ion is collected on a quaternary 4-(N,N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mann opyrannose. Acidic hydrolysis yields [18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
authors.forename: S A
authors.initials: SA
authors.lastname: Toorongian
authors.forename: G K
authors.initials: GK
authors.lastname: Mulholland
authors.forename: D M
authors.initials: DM
authors.lastname: Jewett
authors.forename: M A
authors.initials: MA
authors.lastname: Bachelor
authors.forename: M R
authors.initials: MR
authors.lastname: Kilbourn
mesh_terms: D000837:Anion Exchange Resins; D003837:Deoxy Sugars; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D007553:Isotope Labeling / Q000379:methods*
chemical_list: D000837:Anion Exchange Resins; D003837:Deoxy Sugars; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose