title: Biosynthesis of phosphatidylglycerol and phosphatidylglycerolphosphate in submitochondrial membranes isolated from guinea pig liver is absolutely dependent on CDP-diglycerides imported from microsomal membranes.
abstract: The biosynthesis of radioactively labelled phosphatidylglycerol via phosphatidylglycerophosphate in outer and inner mitochondrial membranes isolated from guinea pig liver was found to depend absolutely on CDP-diglycerides, which could not be biosynthesized in these membranes. The requirement for CDP-diglycerides in the biosynthesis of labelled phosphatidylglycerol could be fulfilled by the transfer of biosynthesized [3H]CDP-diglycerides from the microsomal membranes to the outer and inner mitochondrial membranes.
authors.affiliation: Department of Clinical Biochemistry, Banting Institute, Faculty of Medicine, University of Toronto, Ont., Canada.
authors.forename: L
authors.initials: L
authors.lastname: Stuhne-Sekalec
authors.forename: N Z
authors.initials: NZ
authors.lastname: Stanacev
mesh_terms: D000818:Animals; D001692:Biological Transport; D003567:Cytidine Diphosphate Diglycerides / Q000378:metabolism / Q000502:physiology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000648:ultrastructure; D009702:Nucleoside Diphosphate Sugars; D010715:Phosphatidylglycerols / Q000096:biosynthesis*
chemical_list: D003567:Cytidine Diphosphate Diglycerides; D009702:Nucleoside Diphosphate Sugars; D010715:Phosphatidylglycerols; C034358:phosphatidylglycerophosphate