Electric field increases the phase transition temperature in the bilayer membrane of phosphatidic acid.
The effect of the electric field on the phase transition temperature (Tc) of acidic 1,2-dipalmitoyl-sn-glycero-3-phosphate (DPPA) and 1,2-dipalmitoyl-sn-glycero-3-thionphosphate (thion-DPPA) and zwitterion, i.e. 1,2-dipalmitoyl-rac-3-phosphocholine and 1,2-distearoyl-rac-glycero-3-phosphocholine (DPPC and DSPC), lipids has been investigated. The phase transition was detected using the jump-like increase effect in the conductance of the planar bilayer membrane. A voltage increase to 150 mV has been shown to increase the phase transition temperature in a bilayer lipid membrane (BLM) of phosphatidic acids (DPPA and thion-DPPA) by 8-12 degrees C while the transition temperature in the bilayer of zwitterion lipids (DPPC and DSPC) increases insignificantly. The increasing of Tt in BLM of acidic lipids is attributed to the voltage-induced changes in the molecule packing density.
Antonov
V F
VF
I.M. Sechenov Moscow Medical Institute, U.S.S.R.
Smirnova EYu
Shevchenko
E V
EV
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004560:Electricity; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010712:Phosphatidic Acids; D012997:Solvents; D013696:Temperature
D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010712:Phosphatidic Acids; D012997:Solvents