title: A computer program for modeling the kinetics of gene expression.
abstract: Enzyme induction may be modeled on the basis of four, quantifiable processes that control the rates at which specific gene products accumulate and decay. These processes include synthesis of functional mRNA, translation and degradation of mRNA, and degradation of the protein product. We present a simple computer program that permits mathematical simulation of gene expression on the basis of experimentally determined rates of synthesis and degradation. The program was implemented as a spreadsheet using Microsoft Excel for Macintosh and MS-DOS operating systems and also was adapted for HyperCard on the Macintosh. It contains a formula to account for growth of tissue or cell populations. The program predicts amounts of individual mRNAs and proteins (or enzyme activities) in cells as a function of time after a stimulus alters their rates of synthesis or degradation.
authors.affiliation: Department of Foods and Nutrition, University of Georgia, Athens, 30602.
authors.forename: J L
authors.initials: JL
authors.lastname: Hargrove
authors.forename: M G
authors.initials: MG
authors.lastname: Hulsey
authors.forename: F H
authors.initials: FH
authors.lastname: Schmidt
authors.forename: E G
authors.initials: EG
authors.lastname: Beale
mesh_terms: D000818:Animals; D002455:Cell Division; D003198:Computer Simulation; D004790:Enzyme Induction; D015870:Gene Expression; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D046911:Macromolecular Substances; D008957:Models, Genetic; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism; D051381:Rats
chemical_list: D046911:Macromolecular Substances; D011506:Proteins; D012333:RNA, Messenger