Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats.
A combination of aldosterone (1 micrograms) with either 18-OH-corticosterone (1 micrograms) or 18-OH-19-norcorticosterone (1 micrograms) injected to adrenalectomized rats indicated an amplification of mineralocorticoid activity as expressed by Na/K ratio in urine. Without aldosterone their mineralocorticoid potency was negligible.
Rosenthal
T
T
Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
Shani
M
M
Peleg
E
E
Harnik
M
M
D015069:18-Hydroxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives*; D004347:Drug Interactions; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine
C051358:18-hydroxy-19-norcorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D012964:Sodium; D011188:Potassium; D003345:Corticosterone