Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone.
In a statistically planned study based on quantitative radiography, treatment for 25-26 weeks with the 2 NSAIDs, diclofenac sodium, or indomethacin (both 0.5 and 1.5 mg/kg p.o. daily), or prednisone (6 mg/kg p.o.) had no influence on the progression of spontaneous osteo-arthritis of the knee-joint of the C57BL mouse, by comparison with placebo-treated controls.
Pataki
A
A
Pharmaceuticals Division, Ciba-Geigy Limited, Basle, Switzerland.
Graf
H P
HP
Witzemann
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use*; D011859:Radiography
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D011241:Prednisone; D007213:Indomethacin