Protective effect of sodium molybdate against the acute toxicity of mercuric chloride in rat. VI. The mechanism of stimulative action of sodium molybdate on urinary excretion of mercury.
In order to gain further insight into the protective action of Na2MoO4 pretreatment (1.24 mmol/kg, once a day, i.p.) against the acute toxicity of HgCl2 (30 mummol/mmol/kg, once, s.c.), changes of renal function, tissue accumulation of mercury, and urinary excretions of mercury and phenolsulfonphthalein after exposure to HgCl2 were investigated. Lactate content in the kidney and serum calcium were also measured. Na2MoO4 pretreatment enhanced urinary excretion of mercury. Renal function of Na2MoO4-pretreated rats was better maintained as compared to that of the rats given HgCl2 alone at either dose (30 or 15 mumol/kg) although the metal content in the kidney of this group was almost the same as that of the latter HgCl2-alone rats. This pretreatment prevented the rise in lactate content in the kidney and the reduction of urinary excretion of phenolsulfonphthalein caused by HgCl2, Na2MoO4 reduced serum calcium. These results suggest that Na2MoO4 prevented mercury-induced acute renal failure by decreasing tissue accumulation of the metal through urinary excretion of mercury. Better renal hemodynamics attributable to hypocalcemia may be a causative factor in the enhancement of urinary excretion of mercury.
Koizumi
T
T
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Honma
M
M
Yamane
Y
Y
D000818:Animals; D008297:Male; D008627:Mercuric Chloride / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008628:Mercury / Q000652:urine; D008982:Molybdenum / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
C044659:molybdate; D008627:Mercuric Chloride; D008982:Molybdenum; D008628:Mercury