title: Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and 1-substituted benzothieno[2,3-d]imidazoles.
abstract: The synthesis of 1-substituted benzothieno[2,3-d]imidazoles and their most suitable synthesis precursor 2-nitro-3-substituted-amino benzo[b]thiophenes is reported. Most of these latter compounds show analgesic and antiinflammatory activities sometimes comparable to those of phenylbutazone with less toxicity and gastric lesivity.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Guerrera
authors.forename: L
authors.initials: L
authors.lastname: Salerno
authors.forename: M A
authors.initials: MA
authors.lastname: Siracusa
authors.forename: G
authors.initials: G
authors.lastname: Ronsisvalle
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: M G
authors.initials: MG
authors.lastname: Leone
authors.forename: A
authors.initials: A
authors.lastname: Felice
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005122:Exudates and Transudates / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D009574:Nitro Compounds; D013876:Thiophenes