title: Placetins, platelet aggregation inhibitors from Streptomyces sp. Q-1043. I. Fermentation, isolation and biological properties.
abstract: Placetins, platelet aggregation inhibitors were obtained from the culture broth of Streptomyces sp. Q-1043. These were designated placetins A, A1, B and B1, respectively. Placetins A and B showed strong cytotoxicities against P388, L1210 and HeLa cells.
authors.affiliation: Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ozasa
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Suzaki
authors.forename: C
authors.initials: C
authors.lastname: Nohara
authors.forename: M
authors.initials: M
authors.lastname: Kobori
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001685:Biological Factors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D007941:Leukemia P388; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D001685:Biological Factors; D010975:Platelet Aggregation Inhibitors