[The induction of hepatocyte polyploidization in rats of various ages by ionizing irradiation with different LETs].
A decrease in the effectiveness of neutron-irradiation with respect to fusion of nonproliferating hepatocytes of animals with age was shown by the method of flow cytometry. There was an inverse relationship between the effectiveness of induction of nonproliferating hepatocytes fusion and neutron energy. The process of hepatocyte fusion induced by neutrons was inhibited by uranyl acetate. No age-dependent changes were noted in the induction of polyploidization of proliferating hepatocytes by sparsely ionizing radiation. A hypothesis is proposed concerning a membrane nature of the target responsible for hepatocyte polyploidization induced by densely ionizing radiation.
Gil'iano
N Ia
NIa
Malinovskiĭ
O V
OV
Khair
M B
MB
D000375:Aging / Q000528:radiation effects*; D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002459:Cell Fusion / Q000528:radiation effects; D004735:Energy Transfer; D005434:Flow Cytometry; D005720:Gamma Rays; D006498:Hepatectomy; D008099:Liver / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D009502:Neutrons; D011123:Polyploidy; D051381:Rats
Induktsiia poliploidizatsii gepatotsitov krys raznogo vozrasta ioniziruiushchim izlucheniem s razlichnoĭ LPE.