title: The effect of diltiazem on the cardiovascular response to tracheal intubation.
abstract: The efficacy of diltiazem in the attenuation of the cardiovascular response to laryngoscopy and tracheal intubation was studied in patients who received 0.2 or 0.3 mg/kg diltiazem 60 seconds before the start of laryngoscopy. These data were compared with a control group who received saline. Each group consisted of 10 patients who had elective surgery. Patients who received saline showed a significant increase in mean arterial pressure and rate pressure product associated with tracheal intubation. These increases after tracheal intubation were reduced in diltiazem-treated patients compared with those of the control group (p less than 0.05). The data suggest that a bolus injection of diltiazem is a simple, practical and effective method to attenuate the hypertensive response to laryngoscopy and tracheal intubation.
authors.affiliation: Department of Anaesthesiology, Kobe University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mikawa
authors.forename: J
authors.initials: J
authors.lastname: Ikegaki
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: R
authors.initials: R
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Kaetsu
authors.forename: H
authors.initials: H
authors.lastname: Obara
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004110:Diltiazem / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D004110:Diltiazem