Rodent tumor profiles, Salmonella mutagenicity and risk assessment.
The tumorigenesis profiles of 116 chemicals, which proved to induce cancer in the NCI/NTP experimentation, were studied by multivariate data analysis methods. Three main patterns of tumor induction were evident. One chemical (benzene) was not classifiable in any of the 3 clusters of chemicals. The carcinogen classes based on patterns of tumor induction did not reflect a repartition between Ames-positive and Ames-negative chemicals. Therefore any classification of carcinogens as either 'primary' (genotoxic, hence assumed to pose a greater risk) or 'secondary' (presumably carcinogenic via non-genotoxic mechanisms) would seem to be a subject for research and speculation, and, for the present, an unsuitable basis for risk assessment.
Benigni
R
R
Istituto Superiore di Sanità, Laboratorio Tossicologia Comparata ed Ecotossicologia, Rome, Italy.
D000818:Animals; D002273:Carcinogens; D005260:Female; D008297:Male; D051379:Mice; D015999:Multivariate Analysis; D009153:Mutagens; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats
D002273:Carcinogens; D009153:Mutagens