title: A longitudinal study of pyridoxine and zinc supplementation of lactating women.
abstract: Forty lactating women were randomly assigned to four treatment groups. Beginning at 1-d postpartum the women in each group received a daily vitamin-mineral supplement for 9 mo. The treatments differed only in the amount of vitamin B-6 (0.5 or 4.0 mg pyridoxine) and zinc (0 or 25 mg) included in the supplements. The 4.0-mg pyridoxine supplements significantly increased plasma total vitamin B-6, plasma pyridoxal phosphate (PLP), and milk total vitamin B-6, thus showing that maternal intake exerts a significant effect on vitamin B-6 concentration in milk. There was no effect of vitamin B-6 intake on plasma, erythrocyte, or milk zinc concentration. The 25-mg zinc supplement also had no effect on plasma, erythrocyte, or milk zinc concentration, suggesting that maternal zinc intake is not a major regulator of milk zinc concentration.
authors.affiliation: Department of Human Nutrition and Food Systems, University of Maryland, College Park 20742.
authors.forename: P B
authors.initials: PB
authors.lastname: Moser-Veillon
authors.forename: R D
authors.initials: RD
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D004032:Diet; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D008137:Longitudinal Studies; D008895:Milk, Human / Q000032:analysis*; D009752:Nutritional Status; D011247:Pregnancy; D011732:Pyridoxal Phosphate / Q000097:blood; D011736:Pyridoxine / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D015032:Zinc / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*
chemical_list: D011732:Pyridoxal Phosphate; D015032:Zinc; D011736:Pyridoxine