title: del(2)(p23): a new recurrent abnormality in acute myeloid leukemia.
abstract: In two patients with acute myeloid leukemia, we found a new chromosome abnormality: del(2)(p23) which was detected in 13% and 50% of studied bone marrow cells, respectively. In patient one, del(2p) was an additional abnormality to t(8;21), while patient two had del(2p) as the sole abnormality. Based on our observation and a review of the literature we propose that del(2p) is a new recurrent chromosome abnormality for acute myeloid leukemia.
authors.affiliation: Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, Mount Sinai Medical Center, New York, New York 10029.
authors.forename: V
authors.initials: V
authors.lastname: Najfeld
authors.forename: A
authors.initials: A
authors.lastname: Scalise
authors.forename: S
authors.initials: S
authors.lastname: Fruchtman
authors.forename: K
authors.initials: K
authors.lastname: Troy
mesh_terms: D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*