title: Anti-plasmin inhibitor. VI. Structure of phlorofucofuroeckol A, a novel phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, from Ecklonia kurome Okamura.
abstract: Phlorofucofuroeckol A (1), a novel phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, has been isolated from the brown alga Ecklonia kurome OKAMURA as a potent anti-plasmin inhibitor. Its structure has been elucidated to be 1,11-di(3,5-dihydroxyphenoxy)- benzofuro[3,2-a]dibenzo[b,e][1,4]dioxin-2,4,8,10,14-pentaol on the basis of the spectral data, in particular, by means of negative nuclear Overhauser effect (NOE) and long-range carbon-proton couplings (2JCH and 3JCH). Phlorofucofuroeckol A inhibited the action of alpha 2-macroglobulin (IC50 = 1.0 micrograms/ml) and alpha 2-plasmin inhibitor (IC50 = 0.3 micrograms/ml), the main plasmin inhibitors in plasma.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: M
authors.initials: M
authors.lastname: Kodama
authors.forename: I
authors.initials: I
authors.lastname: Miura
authors.forename: Z
authors.initials: Z
authors.lastname: Kinzyo
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D001572:Benzofurans / Q000032:analysis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004147:Dioxins / Q000032:analysis* / Q000494:pharmacology; D056890:Eukaryota / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D000459:Phaeophyceae / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
chemical_list: D001572:Benzofurans; D004147:Dioxins; D000979:alpha-2-Antiplasmin; C064093:phlorofucofuroeckol A