Comparative evaluation of hepatotoxic side effects of various new trypanocidal diamidines in rat hepatocytes and mice.
A series of new trypanocidal diamidines was tested for their hepatotoxic potential. At a concentration of 0.5 mmol/l almost all agents tested produced leakage of lactate dehydrogenase and reduced viability of isolated rat hepatocytes. In mice serum sorbitol dehydrogenase was raised by a single i.p. dose of 65.5 mumol/kg. Only two agents, compounds 261/115 and 313/40, were free of these effects at this dose or concentration.
Sippel
H
H
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, Fed. Rep. of Germany.
Estler
C J
CJ
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003959:Diamines / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D014344:Trypanocidal Agents / Q000633:toxicity*
D003959:Diamines; D014344:Trypanocidal Agents; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase