[The functional connection of rat habenular nucleus and lateral hypothalamic area in the regulation of cardiovascular activities].
The electrical stimulation of the lateral hypothalamic area (LH) in the rat elicited an obvious rise of the arterial pressure and increase in the heart rate. After the microinjection of lidocaine hydrochloride into the habenular nucleus (Hb) on the same side of the electrode, the vasopressor effect elicited by the electrical stimulation of the LH was blocked by 38.9% and the effect on heart rate was reduced by 44.4%. After the microinjection of lidocaine hydrochloride into the bilateral Hb, the vasopressor effect elicited by the electrical stimulation of the LH was blocked by 40.7% and the effect on heart rate was reduced by 41.2%. After the microinjection of the artificial cerebrospinal fluid into the unilateral or bilateral Hb, the cardiovascular effect elicited by the electrical stimulation of the LH was not affected. The electrical stimulation of the Hb in the rat elicited an obvious rise of the arterial pressure, but the heart rate was not changed significantly. After the microinjection of lidocaine hydrochloride into the LH on the same side of the electrode the vasopressor effect elicited by the electrical stimulation of the Hb was blocked by 63.2%. After the microinjection of lidocaine hydrochloride into the bilateral LH the vasopressor effect elicited by the electrical stimulation of Hb was blocked by 62.6%. After the microinjection of the artificial cerebrospinal fluid into the unilateral or bilateral LH, the cardiovascular effect elicited by the electrical stimulation of the Hb was not affected. The present study shows that the Hb and LH exert synergistic action in the regulation of the cardiovascular activities.
Yang
S N
SN
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun.
Wang
S
S
D000818:Animals; D001794:Blood Pressure; D004558:Electric Stimulation; D006339:Heart Rate; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008012:Lidocaine / Q000494:pharmacology; D008032:Limbic System / Q000502:physiology*; D008845:Microinjections; D051381:Rats
D008012:Lidocaine