Antiulcerogenic and antiinflammatory studies with shilajit.
In folk medicine, shilajit has been used to treat diverse clinical conditions ranging from peptic ulcer to bone healing. The present study was conducted to evaluate the possible antiulcerogenic and antiinflammatory activities of shilajit obtained from the rocky mountains of Zarlek, Badekshan, Afghanistan. Shilajit increased the carbohydrate/protein ratio and decreased gastric ulcer index, indicating an increased mucus barrier. Shilajit was found to have significant antiinflammatory effect in carrageenan-induced acute pedal oedema, granuloma pouch and adjuvant-induced arthritis in rats. The results of the present study thus substantiate the use of shilajit in peptic ulcer and inflammation.
Goel
R K
RK
Department of Pharmacology, Banaras Hindu University, Varanas, India.
Banerjee
R S
RS
Acharya
S B
SB
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008515:Medicine, Ayurvedic; D010437:Peptic Ulcer / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D010936:Plant Extracts