Controlled release of nerve growth factor from a polymeric implant.
Recent studies suggest that neurotrophic factors applied directly to brain tissue may enhance regeneration in the central nervous system. Biocompatible polymeric implants providing a controlled release of nerve growth factor (NGF) for over one month were developed. The released nerve growth factor stimulated neurite sprouting in cultured PC12 cells. While a model polymer with demonstrated biocompatibility was used for the present study, the methods can be extended to other polymer systems. Controlled release implants may be useful in the treatment of Alzheimer's disease.
Powell
E M
EM
Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218.
Sobarzo
M R
MR
Saltzman
W M
WM
D000818:Animals; D002460:Cell Line; D003692:Delayed-Action Preparations; D003712:Dendrites / Q000187:drug effects* / Q000502:physiology; D004343:Drug Implants; D009414:Nerve Growth Factors / Q000008:administration & dosage*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D051381:Rats
D003692:Delayed-Action Preparations; D004343:Drug Implants; D009414:Nerve Growth Factors