title: Are reduction potentials of antifungal agents relevant to activity?
abstract: Cyclic voltammetry data were obtained for several categories of fungicidal agents including quinones (akrobomycin, podosporin A), iminium ions and precursors (pyridazines, 15-azahomosterol, griseofulvin-4'-oxime), and metal derivatives of chelators (pyridine-2-aldehyde thiosemicarbazones). The reductions usually occurred in the range of -0.7 to +0.3 V. Reduction potentials provide information on the feasibility of electron transfer in vivo. Catalytic production of oxidative stress from redox cycling is a possible mode of action. Alternatively, there may be interference with normal electron transport chains.
authors.affiliation: Department of Chemistry, University of Wisconsin, Miwaukee 53201.
authors.forename: P
authors.initials: P
authors.lastname: Kovacic
authors.forename: P F
authors.initials: PF
authors.lastname: Kiser
authors.forename: B A
authors.initials: BA
authors.lastname: Feinberg
mesh_terms: D000935:Antifungal Agents / Q000032:analysis*; D002384:Catalysis; D002614:Chelating Agents / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D004579:Electron Transport; D007097:Imines / Q000032:analysis; D008670:Metals / Q000032:analysis; D010084:Oxidation-Reduction; D011809:Quinones / Q000032:analysis
chemical_list: D000935:Antifungal Agents; D002614:Chelating Agents; D007097:Imines; D008670:Metals; D011809:Quinones