Regional changes of tissue pH and ATP content in rat brain following systemic administration of kainic acid.
Regional metabolic alterations induced by systemic administration of kainic acid were investigated in rat brains. The histochemical study revealed that an acidic pH shift preceded an ATP decrease in the limbic structures. In the hippocampal Ammon's horn, it was noted that a selective decrease of ATP occurred in the dendritic subfield, such as the stratum radiatum and/or the stratum oriens. It was suggested that this selective ATP decrease in the dendrite is directly related to kainate neurotoxicity.
Kobayashi
S
S
Department of Neurosurgery, Faculty of Medicine, Kyoto University, Japan.
Kikuchi
H
H
Ishikawa
M
M
Hashimoto
K
K
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006651:Histocytochemistry; D006863:Hydrogen-Ion Concentration; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009498:Neurotoxins; D000255:Adenosine Triphosphate; D007608:Kainic Acid