[The dynamics of the peptide hydra morphogen in meningitis].
The content of peptide hydra morphogen (PHM) was measured for the first time in blood plasma and CSF by RIA in patients with purulent meningitides. 36 patients were examined. Blood and CSF were withdrawn in the acute period and during early convalescence. In the reference group (patients with acute respiratory diseases of virus etiology, quinsy, pneumonias), the PHM concentration in the blood was 128 +/- 62 fm/ml, that in CSF 66 +/- 14 fm/ml. In purulent meningitis of medium gravity, the content of PHM in blood plasma and CSF did not significantly differ from the control. Grave purulent meningitis was marked by a high content of PHM in blood plasma and CSF, in particular, in the acute period and during early convalescence. It was 1250.30 +/- 191 and 544.03 +/- 159 fm/ml in blood plasma and 1504.38 +/- 475 and 1811.39 +/- 375 fm/ml in CSF, respectively. In grave complicated purulent meningitis, which was mainly observed in persons over 50 years, the content of PHM in blood plasma exceeded but insignificantly the content in the control during the acute period (327.49 +/- 76 fm/ml), followed by further increase (1131.41 +/- 209 fm/ml) by days 8-12 of the disease; within the same time, the content of PHM in CSF did not significantly differ from the control (319.52 +/- 152 and 625.69 +/- 275 fm/ml, respectively). In view of the fact that hypothalamic PHM is of crucial importance in the processes of nervous tissue regeneration, the content of the latter one in CSF in patients with grave purulent meningitis may serve as a criterion for disease course tendencies.
Triasucheva
I G
IG
Miloserdov
Iu V
IuV
Tishchenko
V A
VA
Vinogradov
V A
VA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D003289:Convalescence; D005260:Female; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000378:metabolism*; D008586:Meningitis, Pneumococcal / Q000378:metabolism*; D008875:Middle Aged; D009479:Neuropeptides / Q000032:analysis*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D012141:Respiratory Tract Infections / Q000378:metabolism; D013997:Time Factors; D014777:Virus Diseases / Q000378:metabolism
D009479:Neuropeptides; C032522:head activator peptide; D011761:Pyrrolidonecarboxylic Acid
Dinamika peptidnogo morfogena gidry pri meningitakh.