title: Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis.
abstract: Mean peak concentrations of fluconazole in plasma and vaginal secretions of females after a 150-mg single oral dose were shown to be 2.82 micrograms/ml and 2.43 micrograms/g, respectively. Our results indicate that clinically efficacious concentrations of fluconazole in vaginal secretions are easily achieved after this single oral dose.
authors.affiliation: Queen Charlotte's and Chelsea Hospital for Women, London, United Kingdom.
authors.forename: E T
authors.initials: ET
authors.lastname: Houang
authors.forename: O
authors.initials: O
authors.lastname: Chappatte
authors.forename: D
authors.initials: D
authors.lastname: Byrne
authors.forename: P V
authors.initials: PV
authors.lastname: Macrae
authors.forename: J E
authors.initials: JE
authors.lastname: Thorpe
mesh_terms: D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D014621:Vagina / Q000378:metabolism*
chemical_list: D015725:Fluconazole