Breast cancer at Hiroshima and Nagasaki.
A calculation is made of the incidence of breast cancer at Hiroshima and Nagasaki using the dosimetry of Straume and Dobson. Gamma rays cause a mutation in a critical gene. Using a two hit theory, an estimate of the number of target cells and a time period of 24 years, an estimate of the probability of carcinogenesis is obtained which is in good agreement with observation.
Rosen
P
P
Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000235:genetics; D009689:Nuclear Warfare; D011336:Probability