[Sensitivity of bone marrow cells damaged by antitumor drugs to cytotoxic action of effectors of a normal spleen].
Different cytogenetic effects in bone marrow cells induced by antitumor drugs with different mechanisms of action was studied. The treatment of adriablastine causes the appearance of chromatid deletion, vinblastine-polyploid cells, cyclophosphamide-chromosomal and chromatid aberration in mice. It was shown that bone marrow cells with cytogenetic damage have altered susceptibility to normal spleen cells-effectors cytotoxic action.
Klimova
M Iu
MIu
Bogdashin
I V
IV
Novitskiĭ
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000009:adverse effects; D003602:Cytotoxicity, Immunologic; D004317:Doxorubicin / Q000009:adverse effects; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D014747:Vinblastine / Q000009:adverse effects
D000970:Antineoplastic Agents; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide
Chuvstvitel'nost' povrezhdennykh tsitostatikami kletok kostnogo mozga k tsitotoksicheskomu deĭstviiu éffektorov normal'noĭ selezenki.