[Oxytocin modulation of the functional properties of 3 types of cholinoreceptors in mollusk neurons].
It was found that 10(-8) mol/l oxytocin (OT) application exerted effects on functional properties of three types of acetylcholine (ACh) receptors in neurons identified in the ganglia of Helix pomatia under voltage clamp conditions. OT depressed ACh-induced sodium-potassium-calcium current in neuron RB3 without a shift of the reversion potential. The data obtained show that there are two types (subtypes) of ACh receptors connected with chloride channels. OT decreased the ACh-induced chloride current in neuron F4 and enhanced the ACh-induced chloride current and desensitization of ACh receptors in neurons D5, F86. Effects of OT and serotonin applications were reversible but not additional. Effects of OT injection and OT application were independent. The present results suggest that cyclic AMP may be the second messenger mediating the OT-induced modulation of functional properties of three types of ACh receptors.
Diatlov
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004347:Drug Interactions; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D011950:Receptors, Cholinergic; D010121:Oxytocin; D000109:Acetylcholine
Moduliatsiia oksitotsinom funktsional'nykh svoĭstv trekh tipov kholinoretseptorov v neĭronakh molliuska.