Mutation induction in Chinese hamster lung V79 cells by five alk-2-enals produced by lipid peroxidation.
Five alk-2-enals--pent-2-enal, hex-2-enal, hept-2-enal, oct-2-enal and non-2-enal--produced by lipid peroxidation were tested for mutagenic activity in V79 Chinese hamster cells. At concentrations ranging from 0.003 to 0.3 mM all 5 alk-2-enals induced a dose-dependent increase in the frequency of 6-thioguanine-resistant mutants, and their mutagenic potency was found to increase with the length of the carbon chain. In contrast, only hept-2-enal produced a statistically significant increase in the number of mutations to ouabain resistance.
Canonero
R
R
Institute of Pharmacology, University of Genoa, Italy.
Martelli
A
A
Marinari
U M
UM
Brambilla
G
G
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D015227:Lipid Peroxidation; D009152:Mutagenicity Tests; D009154:Mutation
D000447:Aldehydes; C057348:2-octenal; C013166:2-nonenal; C064600:2-heptenal; C051750:2-hexenal; C064599:2-pentenal