title: Vertebral body trabecular density at the thoracolumbar junction using quantitative computed tomography. A post-mortem study.
abstract: Quantitative computed tomography was used to assess vertebral trabecular density in 26 post-mortem spines from individuals aged between 14 and 80 years. All vertebrae from T10 to L1 were scanned transversely near the mid-vertebral level with calculations of trabecular density in HUs averaged and referenced to a mineral equivalent phantom. An age-related decline in trabecular density was recorded (r = 0.55, p less than 0.0001). Density measures from the anterior aspect of the vertebral body were significantly greater than from postero-lateral regions. From T10 to L1, there was a significant decrease in trabecular density, whereas density measures multiplied by vertebral body cross-sectional area were constant. Predictions of vertebral compressive strength using quantitative computed tomography may become more accurate by increasing the sampling area per scan and including vertebral body cross-sectional area as part of the radiologic assessment.
authors.affiliation: Department of Anatomy and Human Biology, University of Western Australia, Nedlands.
authors.forename: K P
authors.initials: KP
authors.lastname: Singer
authors.forename: P D
authors.initials: PD
authors.lastname: Breidahl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging* / Q000502:physiology; D014057:Tomography, X-Ray Computed / Q000379:methods