title: Malignant cell autolysis caused by intracytoplasmic liberation of lysosomal enzymes.
abstract: An ultrastructural study of the action of peptidoglycans on malignant lymphocytes was made. Glycans acted upon lysosomes labilizing and rupturing the lysosomal membrane. Lysosomal enzymes were discharged directly into the cell cytoplasm. Nucleus, mitochondria and all organelles were digested in situ, resulting in a completely structureless cell. Finally, cancerous cells disintegrated by the detachment of cytoplasmic fragments.
authors.affiliation: Lysomex Laboratories, México, D.F.
authors.forename: C M
authors.initials: CM
authors.lastname: Martínez
authors.forename: S
authors.initials: S
authors.lastname: Ayala
authors.forename: A
authors.initials: A
authors.lastname: Coquet
authors.forename: M
authors.initials: M
authors.lastname: Lepinay
authors.forename: O
authors.initials: O
authors.lastname: Michel
authors.forename: T
authors.initials: T
authors.lastname: Robles
authors.forename: F
authors.initials: F
authors.lastname: Chiang
authors.forename: K
authors.initials: K
authors.lastname: Alexanderson
authors.forename: P E
authors.initials: PE
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Lever
mesh_terms: D000818:Animals; D001329:Autolysis; D003593:Cytoplasm / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D010457:Peptidoglycan / Q000494:pharmacology*; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D010457:Peptidoglycan