[Study of the antigenic structure of hepatitis B virus proteins. I. Synthesis of pre-S fragments of hepatitis B virus proteins and their immunogenicity].
Fragments of hepatitis B virus envelope proteins corresponding to the parts of the pre-S domain were synthesised and immobilized on the carriers with low own immunogenicity. The highest stimulation of the antibody production was observed for the antigens immobilized on microspherical carriers or gelatin modified by H-Gly-Tyr-OH. Among peptides used for immunization, pre-S fragment 134-144, conjugated with microspherical carrier, proved to be the most active.
Tsvetkov
D E
DE
Il'ina
A V
AV
Andreev
S M
SM
Sokolenko
A A
AA
Pavlikov
S P
SP
Pumpen
P
P
Novikov
M A
MA
D000595:Amino Acid Sequence; D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D007114:Immunization; D015151:Immunoblotting; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000138:chemical synthesis / Q000276:immunology*
D006514:Hepatitis B Surface Antigens; D010446:Peptide Fragments; D014759:Viral Envelope Proteins
Izuchenie antigennoĭ struktury belkov virusa gepatitaa B. I. Sintez fragmentov pre-S belkov virusa gepatita B i izuchenie ikh immunogennosti.