Opossum (Didelphis virginiana) "little" and "big" gastrins.
1. "Little" gastrins from most mammalian species are 17 amino acid peptides and the precursor "big" gastrins are 34 amino acid peptides. 2. "Little" gastrins of the New World hystricomorphs, guinea-pig and chinchilla, are 16 amino acid peptides due to deletion of a glutamic acid in the region 6-9 from their NH2-terminus and the corresponding "big" gastrins are 33 amino acid peptides. 3. Antral gastrins from the opossum, a New World marsupial, have a glutamic acid deletion in the same region as the hystricomorph gastrins. 4. Opossum "big" gastrin is a 33 amino acid peptide with the following sequence: less than ELGPQDLPYLTADLSKKQGPWLEEEEAYGWMDF#.
Shinomura
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Y
Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, NY 10468.
Eng
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J
Rattan
S C
SC
Yalow
R S
RS
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005755:Gastrins / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D009893:Opossums / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics / Q000302:isolation & purification*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D005755:Gastrins; D011498:Protein Precursors; C013706:big gastrin