[Glutathione and superoxide dismutase redox system in the development of toxic-infectious shock caused by Yersinia pestis toxin].
The changes in the glutathione-dependent and superoxide dismutase (SOD) enzymatic activity in the rat lungs and liver tissues have been studied after the administration of plague murine toxin (LD100). It has been found out the early toxic effect in 1h in the lungs: 35% SOD and glutathione peroxidase (tributyl hydroperoxide) (GP) decrease, 87% glutathione reductase (GR) increase along with two-hold ascent of ratio GR/Glutathione-S-transferase (GT), GR/GPs. The fundamental ratio GR/GT.GPs rises in 1h 3.7 times and then falls below standard rate (5h). This is the evidence of the lungs antioxidant system potential power exhaustion. It has been established that in the liver, 4 times SOD activity increases in 2h after the toxin injection, and 1.5 times GP (tributyL) hydroperoxide) activity ascends in 1h. The ratio increase (150% for SOD/GP-H2O2 in 2h, 114% for GR/GP (tributyl hydroperoxide) and 61% for GR/GT in 5h) indicates the stable unbalance of this system. The pathogenetic significance of detoxication system disturbances in the lungs and liver tissues under the murine toxin influence is discussed.
Osipova
N I
NI
Cherkasova
T D
TD
Girshovich
M Iu
MIu
Avrorov
V P
VP
Iurkiv
V Iu
VIu
D000818:Animals; D001427:Bacterial Toxins / Q000008:administration & dosage; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010326:Pasteurella Infections / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D012772:Shock, Septic / Q000201:enzymology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D015010:Yersinia pestis
D001427:Bacterial Toxins; D013482:Superoxide Dismutase; D005978:Glutathione
Fermentnaia redoks-sistema glutationa i superoksiddistimustazy v dinamike chumnogo toksiko-infektsionnogo shoka.