title: Brain type creatine kinase in relation to oxygen desaturation in the blood of children with congenital heart disease.
abstract: The concentration of brain type creatine kinase (CK-BB) was measured in blood from the internal jugular vein in 32 children (less than 1 year old) with congenital heart disease. In transposition of the great arteries the CK-BB levels were significantly higher than in children without cyanosis (10.1 +/- 4.1 vs. 3.0 +/- 0.5 ng/ml). A negative correlation was found for CK-BB concentration and arterial oxygen saturation (r = -0.41, p less than 0.02 for all children and r = -0.62, p less than 0.05 for those with tetralogy of Fallot). It is suggested that the increased CK-BB levels in the blood of cyanotic children reflect chronic cerebral hypoxia, which may explain other reports of reduced psycho-intellectual function in patients with cyanotic heart disease.
authors.affiliation: Instituto del Cardiologia, Porto Alegre, Brazil.
authors.forename: R F
authors.initials: RF
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Ekroth
authors.forename: K
authors.initials: K
authors.lastname: Jansson
authors.forename: M
authors.initials: M
authors.lastname: Scallan
authors.forename: R J
authors.initials: RJ
authors.lastname: Thompson
authors.forename: C
authors.initials: C
authors.lastname: Lincoln
mesh_terms: D001921:Brain / Q000201:enzymology*; D003402:Creatine Kinase / Q000032:analysis / Q000097:blood*; D003490:Cyanosis / Q000097:blood / Q000150:complications / Q000523:psychology; D006330:Heart Defects, Congenital / Q000150:complications / Q000201:enzymology* / Q000523:psychology; D006801:Humans; D002534:Hypoxia, Brain / Q000201:enzymology; D007223:Infant; D007231:Infant, Newborn
chemical_list: D003402:Creatine Kinase