Vancomycin-induced toxic epidermal necrolysis.
We have reported a patient who had had renal transplantation for end-stage renal disease; she was treated for fever and presumed sepsis with intravenous tobramycin and vancomycin, with subsequent development of persistent fever, eosinophilia, and a maculopapular rash that progressed to linear bullae. Findings on skin biopsy were consistent with a diagnosis of toxic epidermal necrolysis. Sustained measurable serum concentrations of vancomycin, the temporal response to drug exposure, and the response to steroid therapy suggest vancomycin as the causative agent.
Hannah
B A
BA
Department of Medicine, George Washington University Medical Center, Washington, DC 20037.
Kimmel
P L
PL
Dosa
S
S
Turner
M L
ML
D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D013262:Stevens-Johnson Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014640:Vancomycin / Q000009:adverse effects* / Q000097:blood
D014640:Vancomycin