title: Gastroesophageal reflux scintigraphy with radioactive capsules--a new technique for detection and quantitation of reflux.
abstract: A new technique for performing quantitative gastroesophageal scintigraphy has been described. The method involves administration of radioactivity in capsule form into the stomach; the isotope is released after dissolution of the capsule. The mean time of onset of capsule breakage was 3.3 min (range 2-5 min) and complete dissolution occurred by 6.0 min (range 5-8 min). The appearance of isotope activity in the oesophagus by means of cine scintigraphy was quantified by PDP 11/34 computer (Gamma-11) in terms of percentage of gastroesophageal reflux (GER). In 15 healthy subjects, the percentage of reflux (mean +/- S.D.) in the lower, middle and upper oesophagus was found to be 1.25 +/- 0.67, 0.26 +/- 0.23 and 0.02 +/- 0.04 respectively. We have studied 52 patients using this technique, and results are encouraging.
authors.affiliation: Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Bombay, India.
authors.forename: P S
authors.initials: PS
authors.lastname: Soni
authors.forename: C
authors.initials: C
authors.lastname: Sarojini
authors.forename: B A
authors.initials: BA
authors.lastname: Krishna
mesh_terms: D002214:Capsules; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging*; D006801:Humans; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors
chemical_list: D002214:Capsules; D013671:Technetium Tc 99m Sulfur Colloid