Generalized anxiety disorder: some biochemical aspects.
Fifty-one patients who met DSM-III criteria for generalized anxiety disorder, and who were recruited to participate in a drug outcome study, filled out a variety of rating scales and had blood samples drawn for plasma norepinephrine, epinephrine, and free 3-methoxy-4-hydroxyphenylglycol (MHPG) after a 20-min rest period. This group was compared to 15 normal controls who also had their blood drawn after a 20-min rest period. While the two groups were initially found to have significantly different levels of plasma free MHPG through the use of t tests, this finding was not confirmed by subsequent discriminant analysis.
Munjack
D J
DJ
Department of Psychiatry, University of Southern California School of Medicine.
Baltazar
P L
PL
DeQuattro
V
V
Sobin
P
P
Palmer
R
R
Zulueta
A
A
Crocker
B
B
Usigli
R
R
Buckwalter
G
G
Leonard
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D002707:Chlordiazepoxide / Q000627:therapeutic use; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006018:Glycols / Q000097:blood*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D010556:Personality Tests; D011433:Propranolol / Q000627:therapeutic use
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D002707:Chlordiazepoxide; D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine