title: Effects of Buscopan on gastro-oesophageal reflux and hiatus hernia.
abstract: This prospective study was undertaken to establish whether Buscopan (hyosine butyl bromide) interferes with the detection of a hiatus hernia or induces gastro-oesophageal reflux. One hundred and four consecutive patients were included in the study who came for barium meal and swallow examinations over a period of 3 months. Ten patients were excluded from the study. The examinations were performed by the author. The manoeuvres to detect gastro-oesophageal reflux and hiatus hernia were performed before and after intravenous Buscopan. It was found that Buscopan does not induce gastro-oesophageal reflux in the majority of patients, or interfere with detection of a hiatus hernia. The conclusion of this study is that Buscopan can be given early on in the barium meal examination without a significant effect on hiatal function.
authors.affiliation: Department of Radiology, University College Hospital, London.
authors.forename: R R
authors.initials: RR
authors.lastname: Rajah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage / Q000009:adverse effects*; D004943:Esophagogastric Junction / Q000187:drug effects; D005260:Female; D005764:Gastroesophageal Reflux / Q000139:chemically induced*; D006548:Hernia, Diaphragmatic / Q000175:diagnosis*; D006551:Hernia, Hiatal / Q000175:diagnosis*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012602:Scopolamine Derivatives / Q000009:adverse effects*
chemical_list: D012602:Scopolamine Derivatives; D002086:Butylscopolammonium Bromide