Suppression of x-ray induced transformation by Valium and aspirin in mouse C3H10T1/2 cells.
Two commonly used drugs, Valium (diazepam) and Aspirin (acetylsalicyclic acid), were shown to suppress X-ray induced transformation in mouse C3H/10T1/2 cells. Valium was studied in an ethanol solution. Aspirin, which is soluble in both water and ethanol, was active only in the ethanol solution. Both drugs were effective only when present throughout the entire assay period.
Radner
B S
BS
Harvard School of Public Health, Boston, MA 02115.
Kennedy
A R
AR
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D003975:Diazepam / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D000431:Ethanol; D051379:Mice; D012996:Solutions; D013997:Time Factors
D012996:Solutions; D000431:Ethanol; D003975:Diazepam; D001241:Aspirin