Expression of genes for interleukin-1 alpha and tumour necrosis factor-alpha in newborn mice.
Spleen cells from newborn mice are immunologically non-reactive and do not respond by proliferation to T- or B-cell mitogens. However, they synthesize significant levels of mRNA for interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) after mitogen stimulation. Since these two cytokines mediate many protective activities in the body, they may be important in ensuring the survival of immunologically immature newborns.
Lipoldová
M
M
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
Holán
V
V
D000818:Animals; D000831:Animals, Newborn / Q000235:genetics*; D015870:Gene Expression; D007375:Interleukin-1 / Q000235:genetics*; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha