Modulating effect of alpha-[N,N-[bis(2-hydroxyethyl)]-amino-N- (o-methoxyphenyl)-pyrrolidin-2,5-dione on the chemotherapy of murine tumours.
alpha-[N,N-[bis(2-hydroxyethyl)]-amino]-N- (o-methoxyphenyl)pyrrolidin-2,5-dione (I), an intermediate in the synthesis of pyrrolidinedione-N-mustards, did not exhibit antitumour activity against P388 lymphocytic leukemia, Sarcoma 180 (ascites) and Ehrlich (ascites) carcinoma tumours. The effect of co-administration of (I) with established anticancer drugs was studied against these murine tumours. The activity of 5-fluorouracil against Sarcoma 180 (ascites) and Ehrlich (ascites) carcinoma was significantly enhanced by co-administration with (I). Other anticancer drugs, when co-administered with (I), did not show any enhancing effect.
Ambaye
R Y
RY
Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India.
Indap
M A
MA
Naik
S D
SD
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000188:drug therapy*
D009588:Nitrogen Mustard Compounds; D011760:Pyrrolidinones; C051652:3-(N,N-bis(2-chloroethyl)amino)-1-(2'-methoxyphenyl)pyrrolidine-2,5-dione; D005472:Fluorouracil