[Activity of adenosine and thymidine metabolism enzymes in the blood of cancer patients of various ages].
The activity of metabolic enzymes, adenosine and thymidine, has been studied in the blood serum and lymphocytes of healthy people and oncological patients aged 23-80. An increase in the activity of thymidine kinase (EC 2.7.1.2), an enzyme of thymidine biosynthesis, was observed in the blood serum of oncological patients against a background of a sharp decrease in the activity of thymidine phosphorylase (EC 2.4.2.4), a catabolic enzyme. The revealed enzymic shifts have been observed in breast cancer patients after 36, in patients with the stomach cancer--after 46. It is found that an increase in the activity of adenosine deaminase (EC 3.5.4.4) and 5-nucleotidase of AMP (EC 3.1.3.5) in the blood serum of oncological patients is accompanied by a sharp decrease in the activity of these enzymes in lymphocytes.
Borzenko
B G
BG
D015720:5'-Nucleotidase / Q000097:blood; D000241:Adenosine / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000097:blood; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood / Q000201:enzymology*; D013936:Thymidine / Q000378:metabolism*; D013937:Thymidine Kinase / Q000097:blood; D013939:Thymidine Phosphorylase / Q000097:blood
D013939:Thymidine Phosphorylase; D013937:Thymidine Kinase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000241:Adenosine; D013936:Thymidine
Aktivnost' fermentov obmena adenozina i timidina v krovi onkologicheskikh bol'nykh raznogo vozrasta.