title: Effect of high calcium diet and nitrendipine on the development of high blood pressure in adrenalectomised spontaneously hypertensive rats treated with aldosterone.
abstract: The present investigation was designed to study the effect of high calcium diet and nitrendipine on aldosterone-induced development of high blood pressure in young adrenalectomised spontaneously hypertensive rats (SHR). Animals raised on a control calcium diet (0.5% Ca) or high calcium diet (2.5% Ca) were adrenalectomised aged 5-6 weeks and treated with either aldosterone (1 microgram/day subcutaneously) in propylene glycol or aldosterone (1 microgram/day) plus nitrendipine (20 mg/kg/48 hr subcutaneously) in peanut oil. Controls received the aldosterone or nitrendipine vehicle and treatment lasted two weeks. The animals were given 0.9% NaCl ad libitum. Aldosterone caused a significant increase in systolic BP in adrenalectomised SHR fed the control calcium diet when compared with controls and the aldosterone-induced hypertension was blocked by the high calcium diet and nitrendipine (P less than 0.001, n = 4-7). These findings suggest that high dietary calcium has a protective effect against the development of aldosterone-induced hypertension and may enhance that of nitrendipine.
authors.affiliation: Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906.
authors.forename: W E
authors.initials: WE
authors.lastname: Semafuko
authors.forename: D J
authors.initials: DJ
authors.lastname: Morris
mesh_terms: D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002136:Calcium, Dietary / Q000008:administration & dosage*; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D009568:Nitrendipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
chemical_list: D002136:Calcium, Dietary; D000450:Aldosterone; D009568:Nitrendipine