[Anti-inflammatory and analgesic activity of etofenamate after intramuscular injection in laboratory animals].
Antiphlogistic and Analgetic Activity of Etofenamate in Laboratory Animals after Intramuscular Administration by injection of an oily solution of 10.5; 15; 19.5 mg etofenamate/kg body weight it was possible to inhibit the development of the carrageenan edema in the rat paw. Even four days after the single i.m. injection of etofenamate (active substance of Rheumon i.m.) the swelling of the rat paw is effectively prevented. By the Randall-Selitto-analgesia test it was possible to demonstrate the fast onset. Already 1 h after the injection of 15 mg/kg the pain threshold is increased to about 60%. Even in this testsystem the prolonged efficacy of oil diluted etofenamate can be found.
Pelster
B
B
Antiphlogistika-Forschung, Troponwerke GmbH & Co. KG, Köln.
Dell
H D
HD
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005439:Flufenamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006207:Half-Life; D007273:Injections, Intramuscular; D008657:Metabolic Clearance Rate; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005439:Flufenamic Acid; C015207:etofenamate
Antiphlogistische und analgetische Wirkung von Etofenamat nach intramuskulärer Applikation bei Versuchstieren.