title: Determination of plasma nefopam by liquid chromatography and electrochemical detection.
abstract: A liquid chromatographic method for the determination of plasma nefopam is presented. A combination of liquid- and solid-phase extraction and electrochemical detection gave clean extracts and, hence, a low limit of detection. Calibration curves were linear over at least two orders of magnitude (1-100 ng/ml) making the method suitable for pharmacokinetic studies.
authors.affiliation: Department of Pharmacology and Therapeutics, London Hospital Medical College, U.K.
authors.forename: L C
authors.initials: LC
authors.lastname: Burton
authors.forename: N J
authors.initials: NJ
authors.lastname: Loftus
authors.forename: D W
authors.initials: DW
authors.lastname: Vere
authors.forename: R
authors.initials: R
authors.lastname: Whelpton
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D004563:Electrochemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009340:Nefopam / Q000097:blood*; D010079:Oxazocines / Q000097:blood*; D010087:Oxides / Q000378:metabolism
chemical_list: D010079:Oxazocines; D010087:Oxides; D009340:Nefopam