High-performance liquid chromatographic procedure for the determination of rat plasma concentrations of a new antibacterial agent, (+-)-9-fluoro-6,7- dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H- benzo[i,j]quinolizine-2-carboxylic acid, for topical use.
Koike
M
M
Department of Drug Metabolism, Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd., Japan.
Akiyama
H
H
Shimizu
T
T
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D024841:Fluoroquinolones; D008297:Male; D011807:Quinolizines / Q000008:administration & dosage / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011807:Quinolizines; C062127:nadifloxacin