Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.
The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and (+/-)-butane 1, 3-diol, respectively), are described.
Iyer
R P
RP
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
Uznanski
B
B
Boal
J
J
Storm
C
C
Egan
W
W
Matsukura
M
M
Broder
S
S
Zon
G
G
Wilk
A
A
Koziolkiewicz
M
M
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D009838:Oligodeoxyribonucleotides; D013873:Thionucleotides