title: Embolization of cerebral arteriovenous malformations with bucrylate. Experience in a first series of 29 patients.
abstract: The experience with embolization of intracerebral arteriovenous malformations (AVMs) with bucrylate (isobutyl-2-cyanoacrylate) in 29 patients is reported. In 9 cases (31%) less than 1/3 of the AVM nidus was occluded, in 12 (41%) 1/3 to 2/3, in 4 (14%) more than 2/3, and total occlusion was only seen in 3 cases (10%). One patient was never embolized, owing to procedure complications. At follow-up angiography in 20 patients, partial revascularization was found in 11 AVMs and further occlusion in 2. Complications occurred in 11 cases (38%). Five patients (17%) suffered from hemorrhage: 2 died, one deteriorated severely and 2 recovered. Unintentional embolization or edema resulted in neurologic deficits in 6 patients (21%), permanent in 3 and reversible in 3. Symptomatic improvement was initially found in 13 patients (45%) but was stable only in 9. In 9 patients (38%) embolization was followed by elective surgery or irradiation. The best results were obtained in small and medium-sized AVMs (less than 6 cm) while there was a high risk of complications and an uncertain palliative effect in large AVMs.
authors.affiliation: Department of Diagnostic Radiology, University of Gothenburg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Berthelsen
authors.forename: J
authors.initials: J
authors.lastname: Löfgren
authors.forename: P
authors.initials: P
authors.lastname: Svendsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002015:Bucrylate / Q000008:administration & dosage*; D002533:Cerebral Angiography; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D003487:Cyanoacrylates; D002015:Bucrylate