[The effect of propranolol on the apoprotein spectrum of the blood plasma in patients with ischemic heart disease].
The authors studied the effect of anaprilin monotherapy (dose: 160-200 mg/daily for 10 months) on the level of atherogenic apolipoproteins (apo A, apo B) and fractions of plasma cholesterol in 34 patients with ischemic heart disease, stable exertion angina pectoris (class 2-3). It was established that changes in the plasma lipid and apoprotein spectrum result in an increase of apo B, decrease of apo 1, increase of apo B/apo A1, decrease of high-density lipoprotein cholesterol (HDLCS) and a different dynamics of HDLCS/apo A1. The established changes in the lipid metabolism are of atherogenic character.
Mikhin
V P
VP
Shuliak
L N
LN
Kameneva
A M
AM
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D001059:Apoproteins / Q000097:blood / Q000187:drug effects*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
D001059:Apoproteins; D011433:Propranolol
Vliianie propranolola na spektr apoproteinov plazmy krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa.