Chalcones: a new class of antimitotic agents.
A series of chalcones was evaluated as antimitotic agents. One of these, (E)-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2-pr open- 1-one) (73), was found to be an effective antimitotic agent at a concentration of 4 nM in an in vitro HeLa cell test system. When evaluated in experimental tumor models in vivo, this compound exhibited antitumor activity against L1210 leukemia and B16 melanoma.
Edwards
M L
ML
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
Stemerick
D M
DM
Sunkara
P S
PS
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002453:Cell Cycle / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008938:Mitosis / Q000187:drug effects; D015394:Molecular Structure; D011427:Propiophenones / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011427:Propiophenones; C062014:MDL 27048; D002599:Chalcone