[Effects of organic fluorosilicone compounds on the development of tumors in mice].
The influence of new synthesized fluoro-silicium-organic complexes on the virus-induced Rauscher leukosis and cell-transferred MX-11 mouse sarcoma was studied. We also studied the cytotoxic effects of these complexes in vitro in the human CaOv cells. Two complexes from seven studied were cytotoxic for CaOv cells. Five complexes from seven studied diminished the mortality of animals with MX-11 tumors on the 27-th day of observation, but the total life duration of the animals in the experimental group was the same as in controls. One complex from seven studied increased the life duration of mice with MX-11 tumors. No effects were noted in relation to mice virus-induced Rauscher leukosis.
Snegireva
A E
AE
Shaposhnikova
G M
GM
Ignatenko
M A
MA
Shevliagin
V Ia
VIa
Dobrynin
Ia V
IaV
Nikolaeva
T G
TG
Borovskiĭ
Iu V
IuV
Karabach
O S
OS
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D005463:Fluoroacetates; D006801:Humans; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011925:Rauscher Virus; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D012825:Silicon / Q000627:therapeutic use*; D013997:Time Factors; D014269:Trifluoroacetic Acid; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D005463:Fluoroacetates; D014269:Trifluoroacetic Acid; D012825:Silicon
Vliianie ftorkremniĭorganicheskikh soedineniĭ na razvitie nekotorykh opukholeĭ u mysheĭ.