RU 486 interferes with egg transport and retards the in vivo and in vitro development of mouse embryos.
Oral administration of RU 486 at 100 mg/kg BW/day to mice on Days 1 and 2 of pregnancy caused retention of embryos in the oviduct and expulsion of those having entered the uterus. The treatment also retarded the development of embryos. In vitro study showed that RU 486 reduced the percentage of 2-cell mouse embryos developing into blastocysts. Thus, in addition to interfering with egg transport and impairing embryonic development in vivo, RU 486 can act directly on the embryo, interfering with preimplantation development in vitro.
Yang
Y Q
YQ
Department of Obstetrics and Gynecology, University of Massachusetts Medical Center, Worcester 01655.
Wu
J T
JT
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D015735:Mifepristone / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy
D015735:Mifepristone