Ciprofloxacin concentrations and impact of the colon microflora in patients undergoing colorectal surgery.
Ciprofloxacin was given perorally in two doses of 750 mg each with a 12-h interval starting 24 h prior to surgery, 400 mg of ciprofloxacin was given intravenously at the induction of anesthesia, and 400 mg of ciprofloxacin was given 12 h later to 21 patients undergoing elective colorectal surgery. The maximum concentrations in serum (mean value +/- standard deviation, 11.1 +/- 7.8 mg/liter) during surgery were reached 30 min after ciprofloxacin was administered. The ciprofloxacin concentrations in the intestinal mucosa samples were 2.7 to 37.8 mg/kg of tissue weight, and the concentrations in the fecal samples were less than 0.1 to 858 mg/kg. The aerobic and anaerobic bacteria in the fecal flora were suppressed markedly during the prophylaxis period. No postoperative infections occurred.
Brismar
B
B
Department of Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
Edlund
C
C
Malmborg
A S
AS
Nord
C E
CE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001420:Bacteria, Aerobic / Q000187:drug effects; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D003106:Colon / Q000382:microbiology* / Q000601:surgery*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000601:surgery*
D002939:Ciprofloxacin