title: [Endoscopic studies on the gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled, double-blind study in healthy volunteers].
abstract: Endoscopic Studies on the Gastric Tolerance Following 6 Days Treatment of Paracetamol and Acetylsalicylic Acid/A placebo-controlled double-blind-study in healthy volunteers. In placebo-controlled randomized double-blind cross-over-fashion the gastric and duodenal tolerance of a 6 day treatment with 3000 mg acetylsalicylic acid (ASA; as a commercially available preparation) and 3000 mg paracetamol (Tylenol) were directly compared in 12 healthy volunteers. An endoscopic evaluation of the gastric and duodenal mucosa was performed. 3000 mg ASA daily evoked significant more gastro-duodenal lesions than 3000 mg paracetamol daily and placebo. Difference between Paracetamol and placebo did not reach statistical significance. Based on the comparable analgetic potency of both compounds and the apparently better gastro-duodenal tolerability paracetamol is the drug of choice when a non-inflammatory problem requires an analgesic.
authors.affiliation: Medizinische Universitätsklinik Heidelberg, Gastroenterologische Abteilung.
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Simon
authors.forename: D
authors.initials: D
authors.lastname: Weise
authors.forename: H G
authors.initials: HG
authors.lastname: Dammann
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D004311:Double-Blind Method; D004361:Drug Tolerance / Q000502:physiology; D004386:Duodenum; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D010919:Placebos; D011897:Random Allocation
chemical_list: D010919:Placebos; D000082:Acetaminophen; D001241:Aspirin
vernacular_title: Endoskopische Untersuchungen zur Magenverträglichkeit einer mehrtägigen Gabe von Paracetamol und Acetylsalicylsäure. Eine Plazebo-kontrollierte Doppelblindstudie an gesunden Probanden.