Prednisolone promotes the secretion of progesterone and oestradiol by luteinised granulosa cells independent of human chorionic gonadotropin.
An in vitro model based on luteinised granulosa cells gained during an in vitro fertilisation programme examines the question of whether prednisolone, and thus glucocorticoids in general, are capable of exerting an influence on the secretion of oestradiol and progesterone. It can be demonstrated that prednisolone leads to dosage-dependent increases in the concentration of both steroids, even independently of concurrent stimulation by human chorionic gonadotropin. A similar mechanism for aromatase activity of human adipose cells is suggested.
Würfel
W
W
Universitätsfrauenklinik und Hebammenschule Würzburg, FRG.
Steck
T
T
von Hertwig
I
I
Albert
P
P
D006063:Chorionic Gonadotropin / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008183:Luteal Phase; D011239:Prednisolone / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D011239:Prednisolone