title: Mitochondrial DNA evolution in experimental populations of Drosophila subobscura.
abstract: When two mitochondrial DNA (mtDNA) haplotypes of Drosophila subobscura compete in experimental populations with discrete generations, one or the other approaches fixation, depending on the nuclear background with which they are associated. The approach to fixation, however, is strongly dependent on the effective number of females in the population, Nf. Whether or not the ultimate fate of a given mtDNA haplotype is determined by random genetic drift depends on Nf as well as on the relative fitnesses. Our experimental results show that the mtDNA polymorphisms observed in natural populations are affected by interactions among nuclear polymorphisms, random genetic drift, and direct selection on the mtDNA haplotypes.
authors.affiliation: Departamento de Genética, Facultad de Biología, Universitat de Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fos
authors.forename: M A
authors.initials: MA
authors.lastname: Domínguez
authors.forename: A
authors.initials: A
authors.lastname: Latorre
authors.forename: A
authors.initials: A
authors.lastname: Moya
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002467:Cell Nucleus / Q000502:physiology; D007446:Chromosome Inversion; D004272:DNA, Mitochondrial / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes
chemical_list: D004272:DNA, Mitochondrial