[Lymphocytes as regulators of proliferation and differentiation of cells of non-lymphoid organs].
The morphogenetic function of lymphocytes was studied in their adoptive transfer from operated on donors to the syngeneic recipients (mice or rats). Splenocytes isolated at 2-17 h after extirpation of 2/3 of the liver, one kidney, or 1/2 of the small intestine were found to stimulate proliferation of cells in the recipient's organ homologous to the donor's. The morphogenic activity of splenocytes was directly proportional to the quantity of the removed organ tissue. Splenocytes isolated from the donor spleen after resection of 1/4 of the liver or 1/2 of a kidney showed no morphogenic activity. Splenocytes isolated at 36 h after resection of 2/3 of the liver at 48 h after resection of 1/2 of the spleen, or at 17 h after extirpation of one submandibular salivary gland inhibited proliferation of hepatocytes in the regenerating liver of the recipients. The stimulation effect was predominantly organ-specific, while the inhibition effect had no organ specificity. The involvement of lymphocytes (or lymphocytes with macrophages) in the regulation of cell differentiation was studied on a model after massive haemorrhage. The procedure was followed by a special type of erythropoiesis having distinct morphological markers and named the reserve erythropoiesis. It was demonstrated that the transfer of lymphoid cells and macrophages from anemized donors to normal recipients induced the development of signs of reserve erythropoiesis in the latter.
Babaeva
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AG
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D007421:Intestine, Small / Q000166:cytology*; D007668:Kidney / Q000166:cytology*; D008099:Liver / Q000166:cytology*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008938:Mitosis / Q000502:physiology*; D009928:Organ Specificity; D051381:Rats; D013154:Spleen / Q000166:cytology*; D014185:Transplantation, Isogeneic
Limfotsity kak reguliatory proliferatsii i differentsirovki kletok nelimfoidnykh organov.