title: [Changes in esophageal motility in patients with systemic lupus erythematosus: an esophago-manometric study].
abstract: Impairment of esophageal motor function is well recognized in connective tissue disease. We have investigated esophageal function, by manometric studies, presence of symptoms of esophageal involvement and antibodies pattern, in 18 female patients affected by systemic lupus erythematosus (SLE). Esophageal manometry showed motor abnormalities in 72.3% of the patients, especially hypokinetic abnormalities (hypotony of lower esophageal sphincter pressure, low amplitude or alterations of peristaltic waves) or, rarely, an increase of amplitude of peristaltic contractions. No significant correlation were found between antinuclear antibodies, esophageal symptoms and manometric findings. Hypoperistalsis or aperistalsis, may be due to an inflammatory reaction in the esophageal muscles or to an ischemic vasculitic damage of Auerbach plexus. High amplitude of peristaltic esophageal waves may be due to an early stage of reflux esophagitis: we have found gastro-esophageal reflux symptoms in more than half of our patients.
authors.affiliation: Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Castrucci
authors.forename: L
authors.initials: L
authors.lastname: Alimandi
authors.forename: A
authors.initials: A
authors.lastname: Fichera
authors.forename: L
authors.initials: L
authors.lastname: Altomonte
authors.forename: A
authors.initials: A
authors.lastname: Zoli
mesh_terms: D000328:Adult; D004935:Esophageal Diseases / Q000175:diagnosis; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000503:physiopathology*; D008365:Manometry; D010528:Peristalsis; D011928:Raynaud Disease / Q000175:diagnosis
vernacular_title: Alterazioni della motilità esofagea in pazienti affette da lupus erithematosus sistemicus: studio esofagomanometrico.