title: Gadolinium-enhanced MRI of tumors of the head and neck.
abstract: High-resolution computed tomographic (CT) scanning and, more recently, magnetic resonance imaging (MRI) have provided more accurate evaluation of the extent of head and neck neoplasms. With increasing experience, better methodology is being developed to improve imaging accuracy. We present a series of patients with clinically proven neoplasms of the oropharynx and larynx, evaluated by MR using T1-weighted, T2-weighted, and post-gadolinium (Gd)-DTPA T1-weighted imaged. The concept behind the use of Gd-DTPA was that it might permit the use of only pre- and postcontrast T1-weighted sequences, reducing examination time and increasing the sensitivity of the examination. It was also anticipated that Gd-DTPA could increase tumor conspicuity and edge definition. Imaging planes were chosen to best define the tumor extent and axial images were performed to evaluate adenopathy. The imaging results were compared with the clinical evaluation and with non-Gd-enhanced MRI. We present examples of the significantly improved soft tissue contrast with Gd-DTPA T1-weighted images and discuss the improved tumor margin definition with Gd-DTPA. Those cases in which it does not provide improved information will also be presented.
authors.affiliation: Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: C D
authors.initials: CD
authors.lastname: Phillips
authors.forename: S B
authors.initials: SB
authors.lastname: Gay
authors.forename: R L
authors.initials: RL
authors.lastname: Newton
authors.forename: P A
authors.initials: PA
authors.lastname: Levine
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D019786:Gadolinium DTPA; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis*; D004369:Pentetic Acid; D010610:Pharyngeal Neoplasms / Q000175:diagnosis*
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA