title: Sympathetic nervous system and PC12 pheochromocytoma-derived factors suppress stimulation of lymphocytes.
abstract: We have reported previously that ablation of the sympathetic nervous system augments immune responses in mice and rats. In the present study we show that a factor present in the sympathetic cervical ganglia of newborn rats suppresses Con A-induced stimulation of splenic T lymphocytes significantly whether added prior to, throughout, or following exposure to Con A. We also show that rat PC 12 pheochromocytoma cells secrete a factor which has the same inhibitory effect on T cell proliferation as the sympathetic ganglia-derived factor.
authors.affiliation: Department of Neurology, University of Chicago, Illinois 60637.
authors.forename: E
authors.initials: E
authors.lastname: Chelmicka-Schorr
authors.forename: M E
authors.initials: ME
authors.lastname: Checinski
authors.forename: B G
authors.initials: BG
authors.lastname: Arnason
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003470:Culture Media / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000276:immunology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000276:immunology*
chemical_list: D003470:Culture Media; D003208:Concanavalin A