title: A search for sonoluminescence in vivo in the human cheek.
abstract: In a previous experiment, sonoluminescence was observed in aerated water, especially at the pressure antinodes in the standing-wave field of a physiotherapeutic ultrasound device (Therasonic 1030). Mammalian cells in vitro showed growth inhibition when placed at the pressure antinodes but not at adjacent pressure nodes. In the light of these results, we looked for sonoluminescence in vivo when a similar standing-wave field was set up. To detect luminescence, a light guide was held against the inner surface of the human cheek. This would channel any luminescence photons to a cooled, red-sensitive photomultiplier which would quantify the light. Direct insonation of the cheek produced no detectable luminescence. Similarly when a water bag was placed against the outer surface of the cheek, and the latter was insonated through the bag, no luminescence was detected. Sonoluminescence from the water bag was, however, detected when the bag was placed against the inner surface of the cheek, showing that absorption of sound by the cheek tissue was not preventing cavitation. Further analysis showed that if cavitation had been occurring in the cheek without detection using the system employed, then the resulting sonoluminescence would have to be at most 0.025 times as intense as that produced by an equivalent volume of aerated water.
authors.affiliation: Cavendish Laboratory, Cambridge, UK.
authors.forename: T G
authors.initials: TG
authors.lastname: Leighton
authors.forename: M J
authors.initials: MJ
authors.lastname: Pickworth
authors.forename: J
authors.initials: J
authors.lastname: Tudor
authors.forename: P P
authors.initials: PP
authors.lastname: Dendy
mesh_terms: D000162:Acoustics / Q000295:instrumentation; D002610:Cheek / Q000033:anatomy & histology*; D006801:Humans; D049449:Luminescence; D011827:Radiation; D014159:Transducers; D014465:Ultrasonics