title: Preoptic area estradiol-concentrating neurons project to the hypothalamus in female rats.
abstract: Estradiol (E2)-concentrating neurons afferent to the ventromedial nucleus of the hypothalamus (VMH) were identified by combining fluorescent retrograde tracing with steroid hormone autoradiography. The majority of E2-concentrating neurons that projected to the VMH were located in the medial preoptic area. In the entire medial preoptic area, 10.0% of the E2-sensitive neurons sent axons that terminated in the VMH. Twenty percent of the E2-concentrating neurons located in the periventricular preoptic area projected to the VMH. Of the E2-concentrating neurons found in the medial preoptic nucleus, 8.0% sent axons directly to the VMH. The bed nucleus of the stria terminalis, septum, and medial amygdala contained very few E2-receptive neurons that projected to the VMH. Preoptic area E2-concentrating neurons that project to the VMH may be part of a neural circuit that influences reproduction.
authors.affiliation: Institute of Animal Behavior, Rutgers University, Newark, NJ 07102.
authors.forename: K P
authors.initials: KP
authors.lastname: Corodimas
authors.forename: J I
authors.initials: JI
authors.lastname: Morrell
mesh_terms: D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D009434:Neural Pathways; D011301:Preoptic Area / Q000378:metabolism*; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*
chemical_list: D004958:Estradiol