Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury.
Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.
Waintrub
M L
ML
Webb-Waring Lung Institute, Department of Medicine, University of Colorado, Health Sciences Center, Denver 80262.
Terada
L S
LS
Beehler
C J
CJ
Anderson
B O
BO
Leff
J A
JA
Repine
J E
JE
D000418:Albumins / Q000378:metabolism; D000818:Animals; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008171:Lung Diseases / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D010269:Paraquat / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014414:Tungsten / Q000494:pharmacology; D014968:Xanthine Dehydrogenase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
D000418:Albumins; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D010269:Paraquat; D014414:Tungsten