Effects of a tocolytic oxytocin analogue on lipid and carbohydrate metabolism.
The effect of a newly developed tocolytic oxytocin analogue, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin on lipid and carbohydrate metabolism was investigated. Oxytocin and vasopressin both stimulated lipogenesis in isolated rat adipocytes, an effect which was dose-dependently inhibited by the oxytocin analogue. In vivo, intravenous injection of 10 nmol/kg body weight of the analogue to 11 healthy subjects caused an initial, but insignificant peak after 4 min in both plasma glucose and glycerol, which thereafter remained at basal level. It is concluded that although an antagonistic effect of the analogue on vasopressin- and oxytocin-stimulated lipogenesis could be demonstrated in vitro, the effect on lipid and carbohydrate metabolism in vivo in humans is insignificant.
Eriksson
H
H
Department of Medical and Physiological Chemistry, University of Lund, Sweden.
Björgell
P
P
Akerlund
M
M
Hauksson
A
A
Melin
P
P
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D015145:Tocolysis; D015149:Tocolytic Agents / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology; D014668:Vasotocin / Q000031:analogs & derivatives*
D015149:Tocolytic Agents; D014667:Vasopressins; D010121:Oxytocin; D005947:Glucose; D005990:Glycerol; D014668:Vasotocin