[Tumor imaging using 99mTc-hexamethylpropyleneamine oxime].
Tumor imagings have been performed in 32 tumor sites in 28 patients with a variety of malignancies by using 99mTc-HM-PAO. They have been compared with radionuclide angiography and conventional tumor imagings such as 67Ga citrate or 201TlCl scanning, and then their possible values have been evaluated for the investigation of tumor blood flow. Tumors were clearly visualized in 19 out of 32 sites, with 59% of positive rate. Good correlation was observed between the radioactivity in the tumor site on static image of 99mTc-HM-PAO and the radioactivity at arterial phase on radionuclide angiography, which represents tumor blood flow. The radioactivities in the marginal regions tended to be stronger than those in the center of large tumors. These results indicated that tumor imaging by 99mTc-HM-PAO mainly reflected tumor blood flow. On the other hand, 99MTc-HM-PAO imagings were not well correlated with 67Ga-studies, while they were coincided with all 201Tl scannings performed. It suggested that the affinity of 99mTc-HM-PAO to capillary wall also involved in its accumulation in the tumor. In conclusion, tumor imaging by 99MTc-HM-PAO was able to estimate tumor blood flow, and this examination would be helpful for the management of malignancies.
Fujii
H
H
Department of Radiology, School of Medicine, Keio University.
Hashimoto
T
T
Nakamura
K
K
Sanmiya
T
T
Shimizu
S
S
Okuyama
Y
Y
Hasegawa
T
T
Kubo
A
A
Kinoshita
F
F
Hashimoto
S
S
D000328:Adult; D000368:Aged; D002951:Citrates; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010091:Oximes; D011875:Radionuclide Angiography; D019690:Technetium Tc 99m Exametazime; D013794:Thallium Radioisotopes
D002951:Citrates; D005710:Gallium Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D013794:Thallium Radioisotopes; D019343:Citric Acid; D019690:Technetium Tc 99m Exametazime