Effect of ethylene glycol on rabbit retinas.
Electrophysiological and histological changes in rabbit retinas were induced by the oral application of ethylene glycol. The electroretinogram revealed a reduced photopic and scotopic activity. Birefringent crystalline deposits were found predominantly in the ganglion cell layer and the inner nuclear cell layer of the retina. These retinal findings were associated with depositions of calcium oxalate crystals in the rabbit kidney and liver.
Rossa
V
V
Heinrich-Heine-Universitäts-Augenklinik Düsseldorf, FRG.
Weber
U
U
D000284:Administration, Oral; D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism; D004596:Electroretinography; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000473:pathology
D005026:Ethylene Glycols; D002129:Calcium Oxalate; D019855:Ethylene Glycol