Concentration of salicylate in serum and perilymph of the chinchilla.
The concentration of salicylate in serum and perilymph was measured in chinchillas after intraperitoneal administration of sodium salicylate. Serum salicylate concentration peaked 2 to 4 hours after a single injection. Clearance was approximately complete after 16 hours. The within-subject variability of serum concentration 4 hours after injection was very low. Subject weight significantly affected serum salicylate concentration, with heavier animals showing higher serum levels. The relationship of perilymph to serum salicylate concentration was approximately linear, with a high correlation between measures.
Boettcher
F A
FA
Department of Communicative Disorders and Sciences, State University of New York, Buffalo 14214.
Bancroft
B R
BR
Salvi
R J
RJ
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002682:Chinchilla / Q000378:metabolism*; D034381:Hearing Loss / Q000139:chemically induced*; D006312:Hearing Loss, Bilateral / Q000139:chemically induced*; D007761:Labyrinthine Fluids / Q000378:metabolism*; D010498:Perilymph / Q000378:metabolism*; D012980:Sodium Salicylate / Q000493:pharmacokinetics* / Q000633:toxicity; D013045:Species Specificity; D013997:Time Factors
D012980:Sodium Salicylate