title: Haemophilia, AIDS and lung epithelial permeability.
abstract: Lung 99mTc DTPA transfer was measured in HIV antibody-positive haemophiliacs (11 smokers, 26 nonsmokers, 5 patients with Pneumocystis carinii pneumonia (PCP]. Lung 99mTc DTPA transfer as a marker of lung epithelial permeability was measured as the half time of transfer (from airspace into blood). This half time was faster in smokers compared to nonsmokers and the transfer curve was monoexponential. In nonsmokers no difference was observed between asymptomatic HIV-positive haemophiliacs and normal subjects, with the exception of the lung bases. At the lung bases in HIV-positive haemophiliac nonsmokers the transfer was faster than in normal individuals, implying increased alveolar permeability. Pneumocystis carinii pneumonia resulted in a rapid transfer of 99mTc DTPA (mean T50 of 2 minutes) and the transfer curve was biphasic, confirming previous observations in homosexual HIV antibody-positive patients with PCP. These changes returned to a monoexponential profile by 6 weeks following successful treatment. The DTPA lung transfer study may enable clinicians to instigate therapy for PCP without the need for initial bronchoscopy and provide a noninvasive method for the reassessment of patients should further respiratory signs or symptoms develop. This method is considered to be highly cost-effective in that it obviates the use of factor VIII concentrates required to cover bronchoscopic procedures and, with its early application and ease of use as a follow-up investigation, permits the evaluation of patients on an outpatient basis, thus reducing hospital costs.
authors.affiliation: Department of Nuclear Medicine, Rayne Institute, St. Thomas' Hospital, London, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Doherty
authors.forename: C J
authors.initials: CJ
authors.lastname: Page
authors.forename: C
authors.initials: C
authors.lastname: Harrington
authors.forename: T
authors.initials: T
authors.lastname: Nunan
authors.forename: G
authors.initials: G
authors.lastname: Savidge
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D002463:Cell Membrane Permeability / Q000502:physiology*; D004848:Epithelium / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D006467:Hemophilia A / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D008875:Middle Aged; D004369:Pentetic Acid / Q000493:pharmacokinetics; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology
chemical_list: D004369:Pentetic Acid