c-myc Oncogene expression in colorectal cancer: its use in prognosis and role in colorectal carcinogenesis.
Expression of the c-myc oncogene was studied in 35 cases of colorectal cancer. Elevated expression was found in 46% (16/35) of cases. This elevated c-myc expression was not significantly correlated with tumour stage, tumour size, tumour differentiation or carcinoembryonic antigen gene expression, demonstrating that it is not a useful prognostic indicator in colorectal cancer. The role of c-myc in colorectal carcinogenesis is discussed in the light of these findings and of the recent advances in molecular biology.
Goh
H S
HS
Department of Colorectal Surgery, National University of Singapore.
Soong
T W
TW
Lee
Y S
YS
Ho
J
J
Goh
C R
CR
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000032:analysis; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D009857:Oncogenes; D011379:Prognosis
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D005819:Genetic Markers