Depression by fenoprofen of the rebound contractions' elicited by vagal stimulation and arterial infusion of ATP in the rabbit stomach in vivo.
In the atropine-treated rabbit, vagal stimulation, arterial infusion of ATP or vasoactive intestinal peptide (VIP) caused gastric relaxation. At the end of either vagal stimulation or ATP infusion, but not after VIP, the gastric inhibitory responses were abruptly interrupted by 'rebound contractions'. Administration of fenoprofen depressed or abolished the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. Indomethacin depressed the rebound contractions only at high doses and this effect was not always reproducible.
Baccari
M C
MC
Department of Physiology, University of Florence, Italy.
Calamai
F
F
Staderini
G
G
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D005279:Fenoprofen / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D010666:Phenylpropionates / Q000494:pharmacology*; D011817:Rabbits; D013270:Stomach / Q000187:drug effects / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D010666:Phenylpropionates; D014660:Vasoactive Intestinal Peptide; D000255:Adenosine Triphosphate; D005279:Fenoprofen; D007213:Indomethacin