title: [Influence of the sclerosing of esophageal varices on portal pressure and azygos venous blood flow].
abstract: Endoscopic sclerotherapy is widely employed for esophageal variceal hemorrhage. However it has side effects and can aggravate portal hypertension by suppression of portosystemic shunt. The purpose of the present investigation was to study the effect of variceal thrombosis on hepatic venous pressure gradient and azygos blood flow. Eight alcoholic cirrhotic patients with a first variceal hemorrhage were included. According to Child Pugh's classification, 4 patients were group A, 2 group B and 2 group C. At each session 40 to 60 ml of 1 p. 100 polidocanol were injected into the varices. A hemodynamic study was performed in each patient before and about one week after variceal obliteration (mean 3.3 procedures). Mean value of hepatic venous pressure gradient was 16.6 +/- 5.5 mm Hg and 17.0 +/- 3.8, respectively, before sclerotherapy and after eradication of varices; azygos blood flow 663 +/- 506 ml/mn before and 682 +/- 522 after; cardiac, output was 6.5 +/- 0.7 ml/min before and 6.5 +/- 0.8 after. None of these differences were significant. These results suggest that endoscopic sclerotherapy using polidocanol does not change hepatic venous pressure gradient and azygos blood flow, and does not lower blood flow through the gastroesophageal collaterals draining into the azygos vein. This is consistent with the hypothesis that thrombosis remains localized.
authors.affiliation: Clinique d'Hépato-Gastroentérologie, CHRU de Grenoble.
authors.forename: P
authors.initials: P
authors.lastname: Bourbon
authors.forename: J P
authors.initials: JP
authors.lastname: Zarski
authors.forename: P
authors.initials: P
authors.lastname: Kitmacher
authors.forename: P
authors.initials: P
authors.lastname: Bourlard
authors.forename: J
authors.initials: J
authors.lastname: Machecourt
authors.forename: B
authors.initials: B
authors.lastname: Denis
authors.forename: M
authors.initials: M
authors.lastname: Rachail
mesh_terms: D000328:Adult; D001401:Azygos Vein / Q000503:physiopathology*; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000503:physiopathology*; D012039:Regional Blood Flow; D012422:Rupture, Spontaneous; D012597:Sclerosing Solutions / Q000494:pharmacology* / Q000627:therapeutic use; D014690:Venous Pressure / Q000502:physiology
chemical_list: D012597:Sclerosing Solutions
vernacular_title: Influence de la sclérose des varices oesophagiennes sur la pression portale et le débit veineux azygos.