The ami locus of the gram-positive bacterium Streptococcus pneumoniae is similar to binding protein-dependent transport operons of gram-negative bacteria.
The complete nucleotide sequence of the ami locus of Streptococcus pneumoniae revealed the presence of six open reading frames, amiABCDEF. The predicted Ami proteins are probably involved in a transport system. The AmiA, C, D, E, and F proteins exhibit homology with components of the oligopeptide permeases (opp) of Salmonella typhimurium and Escherichia coli. Intriguingly, the AmiB protein is homologous to ArsC, a cytosolic modifier subunit of the anion pump encoded by the arsenical resistance operon of the R-factor R773 from E. coli. Data are presented which indicate that Ami is indeed a transport system.
Alloing
G
G
Centre de Recherche de Biochimie et de Génétique, Cellulaires du CNRS, Université Paul Sabatier, Toulouse, France.
Trombe
M C
MC
Claverys
J P
JP
D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism; D009876:Operon; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000254:growth & development
D002352:Carrier Proteins; D009842:Oligopeptides