Increased morbid risk for schizophrenia-related disorders in relatives of schizotypal personality disordered patients.
To evaluate whether probands from a clinical sample diagnosed as having DSM-III schizotypal and/or paranoid personality disorder have a familial relationship to the schizophrenia-related disorders, the morbid risk for schizophrenia-related disorders and other psychiatric disorders were evaluated in the first-degree relatives of patients with schizotypal and/or paranoid personality disorder and compared with the corresponding risk for these disorders in the first-degree relatives of patients with other non-schizophrenia-related personality disorders. The morbid risk for all schizophrenia-related disorders, and specifically for schizophrenia-related personality disorders, was significantly greater among the relatives of the probands with schizotypal and/or paranoid personality disorder than among the relatives of probands with other personality disorder. The morbid risk for other psychiatric disorders did not differ significantly between the first-degree relatives of the schizotypal/paranoid personality disorder and the other personality disorder control proband samples. These results suggest a specific familial association between schizophrenia-related disorders, particularly schizophrenia-related personality disorders, and clinically diagnosed schizotypal patients.
Siever
L J
LJ
Psychiatry Service, Bronx (NY) Veterans Administration Medical Center 10458.
Silverman
J M
JM
Horvath
T B
TB
Klar
H
H
Coccaro
E
E
Keefe
R S
RS
Pinkham
L
L
Rinaldi
P
P
Mohs
R C
RC
Davis
K L
KL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics; D008875:Middle Aged; D010260:Paranoid Personality Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology