title: [Identification of bis-quaternary ammonium compounds using mild ionization mass spectrometry].
abstract: Ethonium, an antimicrobial chemotherapeutic agent, was investigated by mass spectrometry (MS) under various ionization conditions: electron impact, field ionization, field desorption (FD) and fast atom ionization. FDMS was found to be the most suitable procedure for ethonium identification. Relation of the ED mass spectra to the distance between the nitrogen atoms in bis-quaternary ammonium compounds is discussed. It was shown that the most intensive ions with m/z 499, 315 in the FD mass spectra corresponded to the ethonium specific fragmentation and their occurrence in the spectra could serve as a sufficient criterion useful in qualitative and quantitative assay of the drug in the sample.
authors.forename: L F
authors.initials: LF
authors.lastname: Sukhodub
authors.forename: M V
authors.initials: MV
authors.lastname: Kosevich
authors.forename: V S
authors.initials: VS
authors.lastname: Shelkovskií
authors.forename: O A
authors.initials: OA
authors.lastname: Boriak
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Volianskií
authors.forename: V I
authors.initials: VI
authors.lastname: Moleva
authors.forename: T A
authors.initials: TA
authors.lastname: Chumachenko
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D013058:Mass Spectrometry / Q000379:methods; D008970:Molecular Weight; D000644:Quaternary Ammonium Compounds / Q000032:analysis*
chemical_list: D000644:Quaternary Ammonium Compounds; C004921:Ethonium
vernacular_title: Identifikatsiia bis-chetvertichnykh ammonievykh soedineniĭ s pomoshch'iu miagkoionizatsionnoĭ mass-spektrometrii.