title: [Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes].
abstract: Total content of phospholipids and their individual components were distinctly increased in microsomal, mitochondrial fractions and in inner mitochondrial membrane of rat hepatocytes under conditions of alloxan diabetes. The concentrations of these substances were decreased in outer mitochondrial membrane. Activation of lipid free-radical oxidation was found in all the membrane structures studied. In microsomal fraction of hepatocytes the rate of hydroxylation reaction was decreased, accompanied by a decrease in content of cytochromes b5 and P-450.
authors.forename: K G
authors.initials: KG
authors.lastname: Karagezian
authors.forename: L M
authors.initials: LM
authors.lastname: Ovsepian
authors.forename: K G
authors.initials: KG
authors.lastname: Adonts
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D006900:Hydroxylation; D007425:Intracellular Membranes / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids; D008315:Malondialdehyde; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Okislitel'nye protsessy i obmen fosfolipidov v membrannykh strukturakh gepatotsitov pri alloksanovom diabete.