Increased apotranscobalamin II levels in rheumatoid arthritis.
The distribution of endogenous cobalamin among serum cobalamin-binding proteins was studied in 30 patients with active rheumatoid arthritis (RA) and 27 in clinical remission. The mean total serum cobalamin concentration (holo-transcobalamin I and II) was similar in both groups of patients, whereas mean apotranscobalamin II was significantly increased in patients with active RA. The clinical significance of this finding is not yet established but it might be a useful parameter for the evaluation of disease activity in RA.
Arnalich
F
F
Department of Medicine, La Paz Hospital, Autonomous Faculty of Medicine, Madrid, Spain.
Zamorano
A F
AF
Benito-Urbina
S
S
Gijón-Baños
J
J
De Miguel
E
E
Peña
J M
JM
Vázquez
J J
JJ
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D014155:Transcobalamins / Q000032:analysis*; D014805:Vitamin B 12 / Q000097:blood
D014155:Transcobalamins; D014805:Vitamin B 12