Tumour-bearing animals synthesize a decreased level of mRNA for the inducible 55,000 MW interleukin-2 receptor.
Spleen cells from mice bearing progressive growing methylcholanthrene-induced syngenic tumours were deeply hyporeactive in response to T-cell mitogens. This hyporeactivity was associated with decreased ability to synthesize mRNA for the inducible 55,000 MW interleukin-2 receptor (IL-2R). Since the expression of functional IL-2R represents one of the early and pivotal events in lymphoid-cell activation, it is suggested that the defect in effective IL-2R expression may be one of the primary factors responsible for the immunological hyporeactivity of tumour-bearing hosts.
Holán
V
V
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
Lipoldová
M
M
D000818:Animals; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D012333:RNA, Messenger / Q000096:biosynthesis*; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D015375:Receptors, Interleukin-2 / Q000235:genetics*; D012513:Sarcoma, Experimental / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D015375:Receptors, Interleukin-2