title: Autoradiographic analysis of iodoamphetamine redistribution in experimental brain ischemia.
abstract: The pathophysiologic significance of iodoamphetamine (IMP) redistribution was analyzed using a double radionuclide autoradiography technique in experimental brain ischemia in the rat. Within 4 hr after unilateral arterial occlusion, IMP almost completely redistributed at 150 min postinjection in the affected areas. At 2 min postinjection, both a remarkable decrease of IMP accumulation and histopathologic change of diminished staining were observed in these areas. The redistribution amplitude was higher in the affected hemisphere, especially in the regions surrounding the ischemic core than in the unaffected hemisphere. These findings were consistent with computer simulation studies of the time course of brain activity based on the standard diffusible tracer model. The results suggest that IMP redistribution in the ischemic area is due to differences of the temporal changes of the brain activity between the unaffected and affected areas and that it is a "physical" phenomenon (only flow related) rather than a "biologic" one.
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Kanazawa University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
authors.forename: H
authors.initials: H
authors.lastname: Oba
authors.forename: K
authors.initials: K
authors.lastname: Shiba
authors.forename: H
authors.initials: H
authors.lastname: Terada
authors.forename: K
authors.initials: K
authors.lastname: Kinuya
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Sumiya
authors.forename: K
authors.initials: K
authors.lastname: Hisada
mesh_terms: D000662:Amphetamines / Q000493:pharmacokinetics; D000818:Animals; D001345:Autoradiography; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000378:metabolism; D003198:Computer Simulation; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine