[Malondialdehyde concentration in the serum of children with chronic renal failure, chronic hemodialysis and kidney transplantation].
The malondialdehyde equivalent (MDE) was measured by the thiobarbiturate method quantitatively in serum of healthy children, children suffering from chronic renal failure and after kidney transplantation. In the reference group (n = 19) a serum concentration of 3.98 +/- 0.84 nmol/ml was found. Elevated MDE serum concentrations were measured in all groups suffering from renal disease: groups with various degree of diminished renal function (7.05 +/- 2.12 nmol/ml; n = 24), children treated by chronic hemodialysis (6.38 +/- 0.98 nmol/ml; previous dialysis and 6.27 +/- 0.63 nmol/ml after dialysis, n = 9) and children after renal transplantation (6.59 +/- 1.14 nmol/ml; n = 13). In the hemodialysis group the MDE concentration was not affected by a single dialysis nor by sixth months dialysis course. A cell-damaging lipid peroxidation in children suffering from renal diseases is reflected by the investigations.
Otting
U
U
Klinik und Poliklinik für Kinderheilkunde, Humboldt-Universität zu Berlin.
Hellmann
C
C
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D012016:Reference Values; D006435:Renal Dialysis
D008314:Malonates; D008315:Malondialdehyde
Malondialdehydkonzentration (MDA) im Serum chronisch niereninsuffizienter, chronisch hämodialysierter und nierentransplantierter Kinder.