[Induction of cytochrome P-450 forms by prolonged administration of nifedipine].
In experiments on male Wistar rats it has been found that nifedipine applied in a dose of 10 mg/kg body weight i.p. daily for 20 days did not significantly increase the total amount of cytochrome P-450 but markedly increased the 7 alpha-, 16 beta- and 6 beta-hydroxylation of androstenedione in liver microsomes, suggesting the induction of cytochromes P-450a, P-450b and P-450p respectively. The induction of cytochrome P-450b was also confirmed immunochemically with polyclonal antibodies against cytochrome P-450b/e.
Guliaeva
L F
LF
Grishanova
A Iu
AIu
Mishin
V M
VM
Koleva
M
M
Stoĭchev
Ts
Ts
Liakhovich
V V
VV
D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D006900:Hydroxylation; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000735:Androstenedione; D003577:Cytochrome P-450 Enzyme System; D009543:Nifedipine
Induktsiia form tsitokhroma P-450 pri dlitel'nom vvedenii nifedipina.