Skin and liver toxicity in experimental Lantana camara poisoning in albino rats.
Dried alcoholic extract of fresh Lantana camara leaves (LE), on oral administration to albino rats of both sexes, induced photodermatitis during exposure to clear sunlight for 1 hr. Its severity was related to the dose of LE and was maximal in rats exposed to sunlight from 4 to 14 hr after feeding LE and gradually declined over 40 hr. Wavelengths of light about 540 to 570 mu only were effective. In control study, the alcoholic extract of edible spinach leaves was only 1/3 in potency and its effect lasted for less than 20 hr. LE did not raise serum bilirubin, SGOT, SGPT or cause liver injury as assessed by light microscopy. However, like CCL4 but unlike spinach extract, LE impaired excretion of BSP by liver, proportionate to the dose and also maximal at 5.5 hr declining thereafter over 40 hr.
Akhter
M H
MH
Department of Pharmacology, All-India Institute of Medical Sciences, New Delhi.
Mathur
M
M
Bhide
N K
NK
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D005260:Female; D008111:Liver Function Tests; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000503:physiopathology; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000139:chemically induced*; D013448:Sulfobromophthalein / Q000032:analysis; D013472:Sunlight
D010936:Plant Extracts; D013448:Sulfobromophthalein