Mycosis fungoides with CNS involvement: neuropsychiatric manifestations and complications of treatment with intrathecal methotrexate and whole-brain irradiation.
The case of a 42-year-old Caucasian male with CNS dissemination of mycosis fungoides is described. This patient developed prominent mental status changes and subtle neurologic signs, and was treated with intrathecal methotrexate and whole-brain irradiation.
Lindae
M L
ML
Department of Dermatology, Stanford University School of Medicine, California.
Luy
J
J
Abel
E A
EA
Kaplan
R
R
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009182:Mycosis Fungoides / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D019965:Neurocognitive Disorders / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D008727:Methotrexate