Evaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. II. Micronucleus test in bone marrow and hepatocytes.
The antileprosy drug, clofazimine, was tested for its possible genotoxicity using micronucleus (MN) tests in mice. A significantly higher incidence of MN in bone marrow erythrocytes, particularly in polychromatic erythrocytes, as well as in regenerated hepatocytes revealed a positive clastogenic effect of the drug. The drug also had a marked antimitotic effect as indicated by a negative correlation with the dose.
Roy
B
B
Environmental Mutagenesis Unit, School of Life Sciences, Sambalpur University, Orissa, India.
Das
R K
RK
D000818:Animals; D000927:Anticonvulsants / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002991:Clofazimine / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests
D000927:Anticonvulsants; D002991:Clofazimine