[The sexual system of fetal and adult male rats of 2 strains after prenatal exposure to glucocorticoids].
Testosterone level in male fetuses and adults after glucocorticoid injection to their mothers on 16-th and 18-th days of pregnancy as well as morphometric characteristics of male adult reproductive system of two outbred strains (aggressive and domesticated) were investigated. Prenatal hormonal treatment resulted in genotype-dependent changes in testosterone level in 21-day-old male fetuses; it was decreased in fetuses of domesticated rats and increased in fetuses of aggressive rats. The direction of these changes coincided completely with the subsequent changes in relative weight of preputial gland and seminal vesicles in adults. Thus, the level of glucocorticoids during prenatal period plays an important role in reproductive system development and the character of the action depends on the genotype.
Shishkina
G T
GT
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects* / Q000254:growth & development; D005838:Genotype; D005865:Gestational Age; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013739:Testosterone / Q000097:blood
D005938:Glucocorticoids; D013739:Testosterone
Polovaia sistema plodov i vzroslykh samtsov krys dvukh liniĭ posle prenatal'nogo vozdeĭstviia gliukokortikoidami.