title: Alcohol-impregnated wipes as an alternative in hand hygiene.
abstract: The antimicrobial effectiveness of four hand-wash products for health care personnel included three liquid soaps that contained 4% chlorhexidine gluconate, 1% triclosan, or no antiseptic ingredient, respectively, and a 30% w/w ethyl alcohol-impregnated hand wipe. These products were evaluated for reduction in bacterial counts on hands after extended use of 15 handwashes per day for 5 consecutive days. The order of greatest to least log reduction among products at the end of the 5-day test period was chlorhexidine gluconate (2.01), triclosan (1.52), alcohol wipe (0.04), and control soap (0.03). Skin condition before and after handwash was assessed for each treatment group. Subjects reported less skin irritation with alcohol wipes than with the two antiseptic products. Repeated washing with alcohol wipes results in reductions in bacterial colony counts comparable with nonmedicated soap, sufficient to prevent transmission of pathogens by the hands in most situations that arise in nonacute health care settings. This evidence, in addition to increased user acceptability reported by the subjects who used alcohol wipes, suggests that alcohol wipes are an acceptable alternative to soap-and-water handwashing in nonacute health care settings.
authors.affiliation: Johns Hopkins University School of Nursing, Baltimore, MD 21205.
authors.forename: A M
authors.initials: AM
authors.lastname: Butz
authors.forename: B E
authors.initials: BE
authors.lastname: Laughon
authors.forename: D L
authors.initials: DL
authors.lastname: Gullette
authors.forename: E L
authors.initials: EL
authors.lastname: Larson
mesh_terms: D000328:Adult; D002710:Chlorhexidine / Q000031:analogs & derivatives*; D015169:Colony Count, Microbial; D004203:Disinfection / Q000379:methods*; D000431:Ethanol; D005260:Female; D006229:Hand Dermatoses / Q000628:therapy*; D006235:Hand Disinfection / Q000379:methods* / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers; D012915:Soaps; D013242:Sterilization / Q000379:methods*; D013501:Surface-Active Agents; D013997:Time Factors; D014260:Triclosan
chemical_list: D010647:Phenyl Ethers; D012915:Soaps; D013501:Surface-Active Agents; D000431:Ethanol; D014260:Triclosan; C010882:chlorhexidine gluconate; D002710:Chlorhexidine