title: [The effect of ascorbic acid administration on its levels in the brain tissue in intact and hypoxic 18-day-old rats].
abstract: A single dose of ascorbic acid, 1 mg/g of body weight by the i.p. route, caused a marked increase of its content in five areas of the brain in 18-day-old laboratory rats, as compared with intact animals. Acute hypoxia at 9000 m mitigated this increase. Conversely a combination of chronic intermittent hypoxia and ascorbic acid administration led in all investigated areas of the brain to a mild but insignificant rise of values except for the vermis cerebelli, where a significant rise at the 5% level of significance occurred.
authors.affiliation: Fyziologický ústav fakulty vseobecného lékarství Univerzity Karlovy, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Schreiber
authors.forename: S
authors.initials: S
authors.lastname: Trojan
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001205:Ascorbic Acid
vernacular_title: Vliv aplikace kyseliny askorbové na její obsah v mozkové tkáni intaktních a hypoxických 18 denních potkanů.