title: Management of endometrial cancer with suspected cervical involvement.
abstract: The 1989 International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer cells for operative assessment of the extent of uterine disease, grade, and sites of metastasis before assigning a stage to the cancer. In the current study, 70 endometrial cancer patients with suspected cervical involvement based on a positive endocervical curettage or punch biopsy were treated with initial surgery followed by tailored radiation or chemotherapy. Only 37% of the patients had operative findings consistent with the preoperative suspicion of stage II disease. Postoperative therapy was determined by the extent of cervical involvement, depth of myometrial invasion, cell type, tumor grade, and the presence and location of extra-uterine disease. Based upon these parameters, 21 patients were believed to have low risk for pelvic recurrence and received no adjuvant therapy (90% 5-year survival); 38 patients received postoperative pelvic radiation because of high-risk factors for pelvic recurrence or pelvic nodal involvement (65% 5-year survival); and 11 patients received chemotherapy and/or extended radiation because of extrapelvic disease (no 5-year survivors). The approach outlined supports initial surgery for cases of endometrial cancer with suspected cervical involvement. This approach permits accurate surgical staging under the new FIGO system, avoids radiotherapy in many patients whose disease is less extensive than suspected preoperatively, and can accomplish good local control with limited morbidity.
authors.affiliation: Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City.
authors.forename: R S
authors.initials: RS
authors.lastname: Mannel
authors.forename: M L
authors.initials: ML
authors.lastname: Berman
authors.forename: J L
authors.initials: JL
authors.lastname: Walker
authors.forename: A
authors.initials: A
authors.lastname: Manetta
authors.forename: P J
authors.initials: PJ
authors.lastname: DiSaia
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*