title: Joining of the c-myc gene and a line 1 family member on chromosome 8 in a human primary giant cell carcinoma of the lung.
abstract: A rearranged c-myc gene found in a human primary giant cell carcinoma of the lung was analyzed. The rearrangement was found in the region about 6 kilobase pairs upstream of the c-myc gene. The breakpoint was joined to a sequence carrying a Line 1 (L1) family member located on chromosome 8. This in vivo rearrangement of the c-myc gene specific to tumor cells may represent one mechanism of activation of a protooncogene during tumorigenesis or tumor progression in human cancer.
authors.affiliation: Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iizuka
authors.forename: M
authors.initials: M
authors.lastname: Shiraishi
authors.forename: M C
authors.initials: MC
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Sekiya
mesh_terms: D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000032:analysis*; D005784:Gene Amplification; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D009857:Oncogenes
chemical_list: D004273:DNA, Neoplasm