Effects of profound sensorineural loss on gerbilline auditory encephalopathy.
To investigate the role of acoustic stimulation in the development of spongiform degeneration in the cochlear nuclei of Mongolian gerbils, the right cochlea in 8 juvenile gerbils was chemically treated by placing sodium chloride (NaCl) crystals on the cochlear round window membrane. Sixty days after NaCl treatment there was extensive damage to the strial, sensorineural and supporting cells of the treated inner ear. The cochlear damage was accompanied by a dramatic decrease in the number and the extent of the spongioid lesions in the ipsilateral cochlear nuclei compared to the contralateral (control) cochlear nuclei. These results lend further support to the hypothesis that the progress of this disorder is related to auditory function.
Moore
H C
HC
Department of Otolaryngology-Head and Neck Surgery, School of Medicine, University of California, Davis 95616.
McGinn
M D
MD
D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D001933:Brain Stem / Q000503:physiopathology; D003051:Cochlea / Q000503:physiopathology; D004594:Electrophysiology; D005724:Ganglia / Q000473:pathology / Q000502:physiology; D005849:Gerbillinae; D006198:Hair Cells, Auditory / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D012965:Sodium Chloride; D013316:Stria Vascularis / Q000473:pathology; D000159:Vestibulocochlear Nerve / Q000503:physiopathology
D012965:Sodium Chloride