[Hereditary cyanosis caused by the presence of abnormal hemoglobin M in the blood: its detection, identification and properties].
A total of 17 cases of anomalous hemoglobin M (Hb M) were detected among subjects of varying nationalities in different regions of the USSR. The methods used for identification of Hb M Saskatoon, Hb M Boston, Hb M Iwate, Hb M Hyde Park have been described, among them--electron paramagnetic resonance. Spectral characteristics, electrophoretic mobility of these Hb in pH gradient, reaction with cyanides, thermal stability, in vitro reduction with methemoglobin reductase, isolated from donor's red blood cells, have been investigated. The functional parameters (log P50 and n) have been determined for hemolysates containing anomalous hemoglobin, as well as for chromatographically pure fractions of anomalous hemoglobins. The importance of the proper diagnosis of hemoglobinosis M has been stressed.
Kazanets
E G
EG
Andreeva
A P
AP
Khangulov
S V
SV
Tokarev
Iu N
IuN
D003490:Cyanosis / Q000097:blood / Q000235:genetics*; D004912:Erythrocytes / Q000032:analysis*; D006449:Hemoglobin M / Q000032:analysis* / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000032:analysis* / Q000235:genetics; D006456:Hemoglobinuria / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007525:Isoelectric Focusing / Q000379:methods; D014586:USSR
D006455:Hemoglobins, Abnormal; C027541:hemoglobin M Boston; C028907:hemoglobin Saskatoon; C027542:hemoglobin M Iwate; D006449:Hemoglobin M
Nasledstvennye ysianozy, obuslovlennye prisutstviem v krovi anomal'nykh Hb gruppy M: vyiavlenie, identifikatsiia, svoĭstva.