Xanthone 1,4-dihydropyridine derivatives with a potent selective bradycardic effect.
A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The tested compounds are weak calcium antagonists but exert potent selective bradycardic effects.
Valenti
P
P
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Chiarini
A
A
Gasperi
F
F
Budriesi
R
R
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000494:pharmacology*
D004095:Dihydropyridines; D014966:Xanthenes