Alterations of urea-insoluble membrane fraction, MP26, of Emory mouse lenses in aging and cataractogenesis.
Purified lens fiber membrane fractions from Emory mouse lenses and cataract-resistant control lenses were compared by SDS-PAGE. The differences in polypeptide patterns were determined for three ages. There was a striking alteration in MP24/MP26 ratio during aging and cataractogenesis which appears to be due to a normal age-dependent conversion of MP26 to MP24, and which is accelerated during cataractogenesis.
Lo
W K
WK
Department of Anatomy, Morehouse School of Medicine, Atlanta, Ga.
Kuck
J F
JF
D000375:Aging / Q000378:metabolism*; D000818:Animals; D020346:Aquaporins; D002386:Cataract / Q000209:etiology / Q000378:metabolism*; D002462:Cell Membrane / Q000648:ultrastructure; D003720:Densitometry; D004591:Electrophoresis, Polyacrylamide Gel; D005136:Eye Proteins / Q000032:analysis*; D007908:Lens, Crystalline / Q000378:metabolism*; D008562:Membrane Glycoproteins; D051379:Mice; D008817:Mice, Mutant Strains
D020346:Aquaporins; D005136:Eye Proteins; D008562:Membrane Glycoproteins; C030328:aquaporin 0