Transient acanthosis nigricans following bone marrow transplantation for lymphoid malignancy.
Transient acanthosis nigricans (AN) was observed 3 months after bone marrow transplantation (BMT) for lymphoblastic lymphoma. The patient had no endocrine abnormality and had not received any drug known to induce AN. Forty-eight months post-BMT no malignancy recurred or appeared. Although usual hyperkeratosis, papillomatosis and acanthosis were present on skin biopsy, these were associated with the finding of keratinocyte necrosis and CD8+ lymphocytic infiltrate. It is suggested that graft-versus-host disease may be one of the triggers for AN.
Ifrah
N
N
Service de Medecine D - Maladies du Sang, CHU Angers, France.
Berger
F
F
Saint-Andre
J P
JP
Martiat
P
P
Gardembas-Pain
M
M
Boasson
M
M
D000052:Acanthosis Nigricans / Q000209:etiology* / Q000473:pathology; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*