title: Ablation of the region anterior and ventral to the third ventricle (AV3V region) in the rat does not abolish the release of oxytocin in response to systemic cholecystokinin.
abstract: The effect of peripheral administration of cholecystokinin octapeptide (CCK8) on release of oxytocin and vasopressin in the anaesthetized rat was investigated in sham-lesioned rats and in rats which had received electrolytic ablation of the region anterior and ventral to the third ventricle (AV3V region). CCK8 evoked a repeatable and dose-dependent release of oxytocin, but not vasopressin, into the systemic circulation of both sham and lesioned rats, confirming that in the rat CCK8 is a selective stimulus for oxytocin release, and showing that this release is not significantly impaired by lesions of the AV3V region.
authors.affiliation: A.F.R.C. Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
authors.forename: R E
authors.initials: RE
authors.lastname: Blackburn
authors.forename: G
authors.initials: G
authors.lastname: Leng
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D002552:Cerebral Ventricles / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010121:Oxytocin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000494:pharmacology*; D014667:Vasopressins / Q000378:metabolism
chemical_list: D014667:Vasopressins; D010121:Oxytocin; D012844:Sincalide