title: Pseudo-first-order alkaline hydrolysis of diethyl tartrate: a baseline study for a polymer matrix used in controlled-release delivery systems.
abstract: The hydrolysis kinetics of a bifunctional group compound, diethyl tartrate, was studied as a function of temperature and pH in the alkaline region. A pH-stat was used to maintain constant pH conditions in the alkaline region. This allowed the studies to be carried out at low ionic strengths and without the use of buffers. The results indicate that the hydrolysis for both steps followed specific base catalysis. The ratio of the two rate constants was 13.31, which was attributed to a strong charge effect in the second step. The results also show that the use of an overall average rate constant may not be acceptable for multifunctional group compounds.
authors.affiliation: School of Pharmacy, University of Connecticut, Storrs 06269.
authors.forename: D S
authors.initials: DS
authors.lastname: Kalonia
authors.forename: A P
authors.initials: AP
authors.lastname: Simonelli
mesh_terms: D002264:Carboxylic Acids / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000032:analysis*; D003692:Delayed-Action Preparations; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013644:Tartrates / Q000032:analysis*; D013696:Temperature
chemical_list: D002264:Carboxylic Acids; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005079:Excipients; D013644:Tartrates; C064501:diethyl tartrate