[Pyridoxal phosphate as an agent for normalizing the monoamine oxidase activity of the brain in radiation sickness].
A study was made of the influence of the coenzyme pyridoxal phosphate on the activity of mitochondrial monoaminoxidase (MAO) catalyzing oxidative deamination of serotonin at the exacerbation of acute radiation disease (on the 6th day after radiation exposure) in different parts of the brain (cerebral hemisphere, stem and cerebellum). Experiments were staged on rabbits, irradiated by x-ray at a dose of 4.5 Gy with a dose rate of 0.33 Gy/min. The peak of radiation disease was characterized by considerable changes in MAO activity resulting in catalysis of oxidative deamination of serotonin in different parts of the brain and in different mitochondrial subfractions. Pyridoxal phosphate produced a positive effect on monoaminoxidase activity, catalyzing serotonin deamination, and as a coenzyme it can be incorporated in a complex of drugs used for normalization of metabolism of mediators of the nervous system as well as for therapy of radiation injuries.
Nagiev
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ER
Tsybul'skiĭ
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D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D003641:Deamination / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism* / Q000528:radiation effects; D011732:Pyridoxal Phosphate / Q000627:therapeutic use*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000201:enzymology; D012701:Serotonin / Q000378:metabolism / Q000528:radiation effects
D012701:Serotonin; D011732:Pyridoxal Phosphate; D008995:Monoamine Oxidase
Piridoksal'fosfat kak sredstvo normalizatsii monoaminoksidaznoĭ aktivnosti golovnogo mozga pri luchevoĭ bolezni.