Influence of acid-base status on plasma catecholamines during exercise in normal humans.
The influence of acid-base status on plasma catecholamines during exercise was investigated in six healthy volunteers. Incremental exercise to 175 W was performed on a bicycle ergometer under four conditions: 1) control, 2) during forced hyperventilation (HV), 3) after pretreatment with acetazolamide (AZE), and 4) while breathing 4% CO2. Resting plasma norepinephrine (PNE) and epinephrine (PE) were not different among the four protocols despite higher resting pH during HV and lower resting pH after AZE [control, 7.4 +/- 0.02; HV, 7.48 +/- 0.03 (P less than 0.005); AZE, 7.36 +/- 0.01 (P less than 0.005) (P values indicate significant differences from the control protocol)]. Resting pH was not different from control during the 4% CO2 study (7.4 +/- 0.01). At the 175-W exercise load, there were significant differences in both pH and PNE. During the control test, pH was 7.38 +/- 0.02, PNE was 951 +/- 164 pg/ml, and PE was 264 +/- 132 pg/ml. During HV, pH was 7.46 +/- 0.5 (P less than 0.001), PNE was 976 +/- 67 pg/ml, and PE was 210 +/- 27 pg/ml. After AZE, pH was 7.31 +/- 0.2 (P less than 0.001), PNE was 1,866 +/- 561 pg/ml (P less than 0.005), and PE was 382 +/- 264 pg/ml. While subjects breathed 4% CO2, pH was 7.29 +/- 0.02 (P less than 0.001), PNE was 1.842 +/- 617 pg/ml (P less than 0.01), and PE was 467 +/- 275 pg/ml.(ABSTRACT TRUNCATED AT 250 WORDS)
Goldsmith
S R
SR
Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55455.
Iber
C
C
McArthur
C D
CD
Davies
S F
SF
D000086:Acetazolamide / Q000494:pharmacology; D000136:Acid-Base Equilibrium; D000328:Adult; D001794:Blood Pressure; D004837:Epinephrine / Q000097:blood*; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006985:Hyperventilation / Q000097:blood / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010101:Oxygen Consumption; D012016:Reference Values
D000086:Acetazolamide; D009638:Norepinephrine; D004837:Epinephrine