[Distribution of neurospecific cardioactive protein-hormone complex in the rat body during experimental myocardial ischemia].
For more than 25 years the chemistry and the function of the protein-hormonal complexes (produced by magnocellular nuclei of human and same animals) have been studied. The methods of radioimmunological analyses (RIA) for the detection of new neuropecific cardioactive protein-hormone "K" (RHK) in rat organism with myocardial ischemia has been developed. Concentration of PHK in various regions of the brain by RIA a four days after the occlusion of the carotid artery has a sharp decrease. Particularly concentration of PHK decreases 100-fold in the cerebral cortex. At the same time the level of PHK content in the blood increased from 13 +/- 0.85 to 630 +/- 3.9 ng/ml. The maximum concentration of PHK shows a sharp rise in the spleen 200-fold of their original level. This distribution pattern implies that PHK may be of importance for peripheral tissues and to the scarring in heart neurosis zone.
Gabrielian
S K
SK
Srapionian
R M
RM
Abelian
Zh G
ZhG
Galoian
A A
AA
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D007028:Hypothalamic Hormones / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D006023:Glycoproteins; D007028:Hypothalamic Hormones; D009419:Nerve Tissue Proteins
Raspredelenie neĭrospetsificheskogo kardioaktivnogo belok-gormonal'nogo kompleksa v organizme krysy pri éksperimental'noĭ ishemii miokarda.