[Cellular kinetics and the nuclear ploidy pattern in relation to the gross pathological classification and location of advanced colorectal cancers as analyzed by DNA-RNA cytofluorometry].
Correlated studies on the cellular kinetics in association with the nuclear ploidy pattern and the pathological morphology of advanced colorectal cancers have been carried out using DNA-RNA cytofluorometry with an AO stain. The results showed that advanced colorectal cancers could be separated into the 3 distinct groups that follow: group I, involving a diploid cell population; group II, a polyploid cell population; and, group II', an aneuploid cell population. The group I type was located in the entire colorectal region, where as groups II and II', were in the sigmoid and rectum. Three groups were mostly Borrmann type 3 cancers, and the gross pathological classification was not found to be related to the ploidy pattern.
Hashimoto
T
T
Dept. of 1st Pathology, Kyoto Prefectural Univ. of Med.
Morotomi
N
N
Itoi
H
H
Urata
Y
Y
Ueda
K
K
Konishi
E
E
Yagi
S
S
Tsuchihashi
Y
Y
Kodama
M
M
Ashihara
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002453:Cell Cycle; D002467:Cell Nucleus / Q000032:analysis; D015179:Colorectal Neoplasms / Q000032:analysis / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011123:Polyploidy; D012334:RNA, Neoplasm / Q000032:analysis*
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm