title: Angiotensin-converting enzyme inhibitors. 9. Novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity.
abstract: A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC50 values for ACEI as low as 7 nM were observed. Discernable diuretic activity was seen for several hydrochlorothiazide-based molecules. Effects of the ACEI and diuretic structures on the respective potencies are discussed.
authors.affiliation: Rorer Central Research, King of Prussia, Pennsylvania 19406.
authors.forename: J N
authors.initials: JN
authors.lastname: Barton
authors.forename: J J
authors.initials: JJ
authors.lastname: Piwinski
authors.forename: J W
authors.initials: JW
authors.lastname: Skiles
authors.forename: J R
authors.initials: JR
authors.lastname: Regan
authors.forename: P R
authors.initials: PR
authors.lastname: Menard
authors.forename: R
authors.initials: R
authors.lastname: Desai
authors.forename: F S
authors.initials: FS
authors.lastname: Golec
authors.forename: L W
authors.initials: LW
authors.lastname: Reilly
authors.forename: T
authors.initials: T
authors.lastname: Goetzen
authors.forename: S N
authors.initials: SN
authors.lastname: Ueng
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis; D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis; D015195:Drug Design; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D011437:Propylamines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D011437:Propylamines; D005998:Glycine