title: Therapeutic value of Gramurin (oxolinic acid) in Shigella infections and Shigella-negative dysentery syndrome.
abstract: A total of 10 Shigella-positive and 10 Shigella-negative dysentery syndrome patients were treated with daily 2-g Gramurin doses for 3 days. Favourable clinical results could be obtained in response to the therapy. The complaints of the patients ceased within 48 hours. Bacterial negativity was recorded on days 3, 4, and 5 after cessation of therapy in Shigella flexneri-positive cases (5 cases), while in case of Shigella sonnei positivity bacterium negativity could be obtained within the abovementioned period in only 3 out of the 5 cases. The presented results of Gramurin therapy in Shigella infections and Shigella-negative dysentery syndrome are virtually congruent with the earlier reported favourable observations of the authors with the drug in these conditions.
authors.affiliation: Department for Infectious Diseases, Dr. Kenézy Gyula Hospital-Outpatient Clinic, Hajdú-Bihar County.
authors.forename: D
authors.initials: D
authors.lastname: Münnich
authors.forename: F
authors.initials: F
authors.lastname: Lehel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004403:Dysentery / Q000188:drug therapy*; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010093:Oxolinic Acid / Q000627:therapeutic use*; D012760:Shigella / Q000302:isolation & purification
chemical_list: D010093:Oxolinic Acid