[The radiosensitivity and thermoresistance of the cells of substrains of rhabdomyosarcoma RA-2 in rats].
The data obtained show that clonogenic RA-2T cells are 2-3 times more thermoresistant than clonogenic cells of the original thermosensitive RA-2T strain as estimated by D0 value upon heating up to 43-45 degrees C. After X-irradiation of rat rhabdomyosarcoma, a decrease in the capacity of forming pulmonary colonies is more pronounced in cells of the thermosensitive RA-2 strain cells than in those of the thermoresistant strain RA-2T (D0 = 1.6 Gy and D0 = 2.4 Gy, respectively). In all appearance, within one and the same tumor cell population, the hereditarily thermoresistant cells are more radioresistant than the thermosensitive ones.
Fedorova
E V
EV
Trusova
V D
VD
Vakhtin
Iu B
IuB
D000818:Animals; D002461:Cell Line, Transformed; D004307:Dose-Response Relationship, Radiation; D006358:Hot Temperature; D009368:Neoplasm Transplantation; D011836:Radiation Tolerance; D051381:Rats; D012208:Rhabdomyosarcoma / Q000473:pathology / Q000532:radiotherapy*; D014410:Tumor Stem Cell Assay
Radiochuvstvitel'nost' i termoustoĭchivost' kletok subshtammov rabdomiosarkomy RA-2 krys.