Development of spiral ganglion cells in mammalian cochlea.
The development of the spiral ganglion in the cat, the rat, and the mouse was studied by electron microscopy, from fetal stages in the cat and from birth in the rodent. In the earliest stages, a single population of ganglion cells is present. Immature spiral ganglion neurons possess small perisomatic processes that seem to disappear with development, before the myelination ganglion cells are surrounded by one or two layers of Schwann cell processes. With maturation, the Schwann process increases in number around the perikaryon and its processes, which leads to the onset of myelination. The onset of myelination of the cell body processes is asynchronous. The perikaryon may be delayed in myelination by several days. Moreover, ganglion neurons from a given region of the cochlea do not myelinate simultaneously. The differentiation of two types of fibers in the intraganglionic spiral bundle and the first appearance of TII neurons occurs around birth in the cat and a few days after birth for the rat and the mouse. The distinction of TII cells is possible due to characteristic accumulation of neurofilamentous structures in the cytoplasm.
Romand
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MR
Laboratoire de Neurobiologie, Université Blaise Pascal, Aubière, France.
Romand
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R
D000818:Animals; D002415:Cats; D002454:Cell Differentiation; D003051:Cochlea / Q000196:embryology / Q000254:growth & development* / Q000294:innervation* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000166:cytology / Q000648:ultrastructure; D013136:Spiral Ganglion / Q000196:embryology / Q000254:growth & development* / Q000648:ultrastructure