Granule cells in the ventral, but not dorsal, dentate gyrus are essential for kainic acid-induced wet dog shakes.
Intrahippocampal injections of colchicine selectively destroy dentate granule cells. Wet dog shaking elicited by systemic administration of kainic acid is eliminated by bilateral destruction of ventral dentate granule cells but unaffected by bilateral destruction of dorsal dentate granule cells. This implies that ventral dentate granule cells are essential for the generation of kainic acid-induced wet dog shakes.
Grimes
L M
LM
Biological Sciences Research Center, University of North Carolina, Chapel Hill 27514.
Earnhardt
T S
TS
Mitchell
C L
CL
Tilson
H A
HA
Hong
J S
JS
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*
D007608:Kainic Acid