Codon discrimination due to presence of abundant non-cognate competitive tRNA.
It has been thought that preferential use of synonymous codons provides high efficiency and fidelity of protein synthesis through specific codon-anticodon interactions. In yeast genes, some codon boxes seem to prefer a codon which is unsuited for its cognate anticodon. Now, we propose that codon usage biases may arise due to presence of abundant non-cognate competitive tRNA capable of misreading a codon by C-U or G-U pairing in the middle position.
Kato
M
M
Laboratory of Molecular Biology, College of Integrated Arts and Sciences, University of Osaka Prefecture, Japan.
D003062:Codon / Q000235:genetics*; D012331:RNA, Fungal / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D012343:RNA, Transfer / Q000235:genetics*; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000235:genetics; D015003:Yeasts / Q000235:genetics
D003062:Codon; D012331:RNA, Fungal; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D012343:RNA, Transfer