Antroduodenal manometry in the evaluation of chronic functional gastrointestinal symptoms.
Intraluminal pressure in the gastric antrum and duodenum was studied in 44 children and adolescents referred for evaluation because of functional symptoms, including vomiting, abdominal distension, and abdominal pain. Manometric abnormalities were found in 39 patients (89%). Abnormalities during fasting included absence of the migrating motor complex; retrograde, phase 3-like episodes; increased frequency, decreased duration, and decreased amplitude of phase 3 episodes; tonic duodenal contractions; nonpropagated bursts of duodenal contractions; and consistently low-amplitude or absent contractions. Postprandial abnormalities included a phase 1-like pattern (postprandial hypomotility) and phase 3-like episodes (failure to induce a fed pattern). The presence or absence of the migrating motor complex was a predictor of disability. Parenteral alimentation was needed by only 4 of 28 patients with the migrating motor complex, but by 13 of 16 patients without the migrating motor complex (P less than .001). In 15 of 18 patients studied on consecutive days, oral cisapride was associated with increases in the number and amplitude of duodenal contractions after a complex-liquid meal (P less than .02). It is concluded that antroduodenal manometry is a useful technique that elucidates the underlying gastrointestinal motility disorder present in the majority of children and adolescents with severe functional symptoms.
Hyman
P E
PE
Department of Pediatrics, Harbor-UCLA Medical Center, Torrance 90502.
Napolitano
J A
JA
Diego
A
A
Patel
S
S
Flores
A F
AF
Grill
B B
BB
Reddy
S N
SN
Garvey
T Q
TQ
Tomomasa
T
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D020117:Cisapride; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology*; D005215:Fasting / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D008365:Manometry / Q000379:methods; D010880:Piperidines; D011706:Pyloric Antrum / Q000187:drug effects / Q000503:physiopathology; D012189:Retrospective Studies; D012702:Serotonin Antagonists; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*
D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride