The polysulphated polyxylan Hoe/Bay-946 inhibits HIV replication on human monocytes/macrophages.
Due to the important role of monocytes/macrophages in the pathogenesis of AIDS, potential drugs with anti-HIV activity in lymphocytes must also be effective in monocytes/macrophages. For testing the efficacy of antiviral substances, monocytes/macrophages from peripheral blood were infected, respectively, with highly replicating HIV1 and HIV2 strains, thereby providing an extremely sensitive system of testing. Azidothymidine was found to inhibit both HIV types at 0.04 microgram/ml. The polysulphated polyxylan, Hoe/Bay-946 (MW 6,000 Daltons), which acts through a different mechanism and is being tested in clinical pilot studies in Germany, was also found to be effective against HIV1 and HIV2 in macrophages at concentrations of 10-50 micrograms/ml.
von Briesen
H
H
Chemotherapeutisches Forschungsinstitut, Georg-Speyer-Haus, Frankfurt, FRG.
Meichsner
C
C
Andreesen
R
R
Esser
R
R
Schrinner
E
E
Rübsamen-Waigmann
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology*; D009000:Monocytes / Q000187:drug effects / Q000382:microbiology*; D010426:Pentosan Sulfuric Polyester; D011134:Polysaccharides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester