title: Ribosomal RNA gene sequences and hominoid phylogeny.
abstract: Sequences totaling 3,500 bases from the 28S rRNA gene and from one of the ribosomal internal transcribed spacers (ITS1) have been determined for human, chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus). Analyses of the rRNA alignments show (1) a clustering of substitutions in the "variable regions" of the 28S gene, (2) a 1.5-3-fold increase in divergence in the transcribed spacer over that in the exon, and (3) that human and chimpanzee are the most closely related pair, in agreement with the results of Miyamoto et al., Sibley and Ahlquist, and Caccone and Powell.
authors.affiliation: Pathology Department, Hahnemann University, Philadelphia, Pennsylvania 19102.
authors.forename: I L
authors.initials: IL
authors.lastname: Gonzalez
authors.forename: J E
authors.initials: JE
authors.lastname: Sylvester
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Stambolian
authors.forename: R D
authors.initials: RD
authors.lastname: Schmickel
mesh_terms: D000818:Animals; D001483:Base Sequence; D006071:Gorilla gorilla / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics; D010802:Phylogeny; D011148:Pongo pygmaeus / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics*; D012339:RNA, Ribosomal, 28S / Q000235:genetics*; D051381:Rats; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012335:RNA, Ribosomal; D012339:RNA, Ribosomal, 28S