Mania after brain injury: neuroradiological and metabolic findings.
We present a consecutive series of 8 patients who developed a manic episode after a brain injury. Five patients had cortical lesions (4 with damage to the right basotemporal region, and 1 with bilateral damage to the orbitofrontal area). While the other 3 patients had subcortical lesions (white matter of the right frontal lobe, right anterior limb of the internal capsule, and right head of the caudate), a fluorodeoxyglucose positron emission tomography scan showed hypometabolism in the right lateral basotemporal region in all 3 patients. These findings suggest a major role for the basal region of the right temporal lobe in the modulation of mood.
Starkstein
S E
SE
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Mayberg
H S
HS
Berthier
M L
ML
Fedoroff
P
P
Price
T R
TR
Dannals
R F
RF
Wagner
H N
HN
Leiguarda
R
R
Robinson
R G
RG
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging