title: Intravenous propofol anaesthesia using a computerised infusion system.
abstract: Propofol offers many advantages as a total intravenous anaesthetic agent compared with other agents. However, considerable experience is necessary in order to give an uncomplicated anaesthetic. A mathematical model which describes the pharmacokinetic behaviour of the drug was incorporated into a computerised delivery system which enables the anaesthetist to achieve and maintain a target blood concentration of propofol and to manipulate this at will. The system was used to provide general anaesthesia for 33 healthy patients who underwent general surgery. A strong statistical relationship was found between measured blood propofol concentrations and the corresponding computer predictions (y = -0.50 + 1.36x). No significant differences in this relationship were found between patients who breathed spontaneously (y = -0.71x + 1.43x) and those who received intermittent positive pressure ventilation (y = -0.33 + 1.32x).
authors.affiliation: University Department of Anaesthesia, Glasgow Royal Infirmary.
authors.forename: M
authors.initials: M
authors.lastname: White
authors.forename: G N
authors.initials: GN
authors.lastname: Kenny
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008838:Microcomputers; D008875:Middle Aged; D008954:Models, Biological; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D015742:Propofol