Morphine, morphine-6-glucuronide and morphine-3-glucuronide concentrations in plasma and cerebrospinal fluid during long-term high-dose intrathecal morphine administration.
The kinetics of morphine, morphine-6-glucuronide (M6G), and morphine-3-glucuronide (M3G) were studied in a 56-year-old female with lung cancer. Long-term treatment with morphine intrathecally 28 mg every 6 h was used for pain control. Cerebrospinal fluid (CSF) concentrations of morphine were high with an elimination half-life of 2.1 h. The plasma/CSF ratios for M6G and M3G were 1:0.8 and 4:1, respectively, suggesting that M6G penetrates the blood-brain barrier more easily than M3G. The low CSF concentrations indicate that M6G played hardly any major analgetic role in the patient studied.
Bigler
D
D
Pain Clinic, Bispebjerg Hospital, CopenhagenDenmark Department of Pharmacology, University of Copenhagen, CopenhagenDenmark.
Christensen
Broen C
BC
Eriksen
J
J
Jensen
H N
HN
D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008875:Middle Aged; D009020:Morphine / Q000097:blood* / Q000134:cerebrospinal fluid; D009022:Morphine Derivatives / Q000097:blood* / Q000134:cerebrospinal fluid; D009994:Osmolar Concentration; D013997:Time Factors
D009022:Morphine Derivatives; C035349:morphine-6-glucuronide; D009020:Morphine; C018108:morphine-3-glucuronide