Development of 5q- myelodysplasia in a patient with sarcoidosis.
Sarcoidosis has been observed in association with numerous blood dyscrasias including lymphoma, leukemia, and multiple myeloma. This report describes a patient with sarcoidosis and a refractory anemia whose bone marrow karyotype showed deletion of the long arm of chromosome 5, consistent with a myelodysplastic syndrome. Concurrent sarcoidosis and myelodysplasia may relate to the continued availability of cytokines as a consequence of repeated macrophage, T-cell, and B-cell interactions, with evolution to the 5q- abnormality. This association may merit specific attention in the future approach to the diagnostic evaluation in certain patients with sarcoidosis.
Tunkel
A R
AR
Department of Medicine, Medical College of Pennsylvania, Philadelphia.
Sebastianelli
K J
KJ
Pandit
N
N
Brody
J I
JI
D000368:Aged; D000753:Anemia, Refractory / Q000150:complications*; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics; D012507:Sarcoidosis / Q000150:complications* / Q000235:genetics