[Effect of amlexanox on experimental allergic rhinitis in actively sensitized guinea pigs].
The effect of amlexanox given orally for 3 weeks was studied on the IgE-mediated experimental allergic rhinitis in the actively sensitized guinea pigs. The intranasal instillation of antigen (egg albumin) induced the increase of nasal vascular permeability (dye leakage), histamine content in nasal perfusate and nasal resistance in sensitized guinea pig. Amlexanox, 20 and 60 mg/kg/day given orally for 3 weeks significantly inhibited the increase of dye leakage into the nasal cavity, histamine content and nasal resistance in a dose-dependent manner. These results suggest that amlexanox given orally may be useful therapeutic agent for human allergic rhinitis.
Ukai
K
K
Department of Otorhinolaryngology, Mie University School of Medicine.
Atsushi
Yuda
Nonoyama
T
T
Sakakura
Y
Y
Ahida
Y
Y
D000403:Airway Resistance / Q000187:drug effects; D000631:Aminopyridines / Q000627:therapeutic use*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D007114:Immunization; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000503:physiopathology; D013189:SRS-A / Q000037:antagonists & inhibitors
D000631:Aminopyridines; D013189:SRS-A; D006632:Histamine; C045742:amlexanox