Dietary fat and the risk of breast cancer.
Age-adjusted dietary fat intake of 133 incident Dutch breast cancer cases was significantly (p less than 0.01) higher than in 289 apparently healthy controls (mean and standard deviation: 102 +/- 36 g and 92 +/- 30 g, respectively). The age-adjusted relative odds of breast cancer showed a positive trend (p less than 0.05) with increasing fat intake. The multivariate adjusted relative odds was 3.5 (95% Cl = 1.6-7.6) for subjects in the highest quintile of fat intake (above 113 g) compared to those in the lowest quintile (below 65 g); this corresponds to a 30% increased risk per 10% of energy derived from fat. The association could not be attributed to energy intake, nor to the degree of saturation of the fat nor to any specific dietary source of fat.
Van't Veer
P
P
TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Kok
F J
FJ
Brants
H A
HA
Ockhuizen
T
T
Sturmans
F
F
Hermus
R J
RJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D004034:Diet Surveys; D004041:Dietary Fats / Q000009:adverse effects*; D004435:Eating; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009426:Netherlands; D012307:Risk Factors
D004041:Dietary Fats