Structure-activity relationships for osteolathyrism. III. Substituted thiosemicarbazides.
Eight substituted thiosemicarbazides were assayed for their toxicity and teratogenicity using early embryos of Xenopus laevis. Results of the 96-h static tests on seven 4-position alkyl substituents were used for quantitative structure-activity relationship (QSAR) analyses, with thiosemicarbazide as the parent compound. The compounds induced malformations via the connective tissue defect osteolathyrism. Teratogenicity (log EC50) was negatively correlated with molar refractivity, suggesting that steric inhibitions were important in explaining the variations in biological activity due to changes in the 4-position substituent. It appeared that there were two separate modes of lethal action, one associated with the ring-containing substituents and the other with straight-chain substituents. However, QSARs were not developed for embryolethality (log LC50) or for the mortality/malformation index (LC50/EC50) due to the limited number of chemicals eliciting each lethal mode of action.
Dawson
D A
DA
College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
Schultz
T W
TW
Baker
L L
LL
Mannar
A
A
D000818:Animals; D001847:Bone Diseases / Q000139:chemically induced*; D055598:Chemical Phenomena; D002621:Chemistry; D007842:Lathyrism / Q000139:chemically induced*; D012663:Semicarbazides / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013723:Teratogens; D014982:Xenopus laevis
D012663:Semicarbazides; D013723:Teratogens; C005151:thiosemicarbazide