title: Risk factors for postvitrectomy fibrin formation.
abstract: We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular fibrin formation and the association of a variety of preoperative and intraoperative variables with the formation of severe postvitrectomy fibrin. Overall, 62 (32%) patients developed postvitrectomy fibrin; 25 (13%) had mild fibrin formation, 13 (6.5%) had moderate fibrin formation, and 24 (12.4%) had severe fibrin formation. By logistic multivariate analysis, preoperative factors that were independently predictive of severe fibrin formation included severe flare (P = .004), the presence of a previously placed scleral buckle (P = .001), and poor preoperative visual acuity (P = .007). Anterior epiretinal membrane dissection was the only intraoperative factor that was independently associated with an increased fibrin risk (P = .0003). A risk score derived from the multivariate analysis effectively categorized patients according to their likelihood of developing severe postvitrectomy fibrin. Results of this study may be useful in designing prophylactic interventions to decrease postvitrectomy fibrin formation.
authors.affiliation: Medical College of Wisconsin, Milwaukee.
authors.forename: G J
authors.initials: GJ
authors.lastname: Jaffe
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.forename: D P
authors.initials: DP
authors.lastname: Han
authors.forename: M
authors.initials: M
authors.lastname: Gottlieb
authors.forename: A
authors.initials: A
authors.lastname: Hartz
authors.forename: D
authors.initials: D
authors.lastname: McCarty
authors.forename: W F
authors.initials: WF
authors.lastname: Mieler
authors.forename: G W
authors.initials: GW
authors.lastname: Abrams
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005128:Eye Diseases / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D012307:Risk Factors; D012591:Scleral Buckling; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects*
chemical_list: D005337:Fibrin