[Consequences of bacterial product interaction with the immune system in newborn mice].
The immunological competence of a newborn mice group, inoculated with a heat killed suspension of staphylococci, was studied to find out if the treated mice preserved the immunological competence of the T lymphocytes, for induce an allograft. A group of CD1 newborn male mice were injected intraperitoneally with the bacterial suspension, every three days during a four weeks period. Other group received only isotonic saline solution. The lymphocyte ability to form hemolytic plaques and their capacity to provoke a local graft-versus-host reaction in F1 receptor animals was studied in both groups. The results showed that the staphylococci treated newborn mice had a decreased capacity to form anti-erythrocyte antibodies without modification in their reactivity against histoincompatible antigens. Newborn mice, runting-like disease; bacterial inoculation; immunological response in.
García-Tamayo
F
F
Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, D.F.
Aguilar
A E
AE
Rivera
R
R
de León
S
S
Pastelín
R
R
Lastra
M D
MD
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000276:immunology*; D000917:Antibody Formation; D001427:Bacterial Toxins / Q000008:administration & dosage / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000276:immunology*; D051379:Mice; D013211:Staphylococcus aureus; D013535:Suspensions
D001427:Bacterial Toxins; D013535:Suspensions
Consecuencias de la interacción de productos bacterianos con el sistema inmunológico de ratones recién nacidos.