title: Pharmacokinetics of amikacin during continuous veno-venous hemofiltration.
abstract: We studied the pharmacokinetics of amikacin in a patient with acute oliguric renal failure during continuous veno-venous hemofiltration (CVVH). The volume of distribution, terminal disposition rate constant and elimination half-life for amikacin were 27.9 L, 0.023.h-1 and 29.7 h, respectively. Total body clearance for amikacin was 10.54 ml/min and CVVH clearance was 10.11 ml/min. Sieving coefficient for amikacin was 0.93 +/- 0.16. Our data show that during CVVH at a filtration rate of 10 ml/min, the clearance of amikacin is similar to that reported in patients with renal failure who are not being treated with CVVH.
authors.affiliation: Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA.
authors.forename: E
authors.initials: E
authors.lastname: Armendariz
authors.forename: L
authors.initials: L
authors.lastname: Chelluri
authors.forename: R
authors.initials: R
authors.lastname: Ptachcinski
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000628:therapy; D000583:Amikacin / Q000493:pharmacokinetics*; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008875:Middle Aged
chemical_list: D000583:Amikacin