title: [Synthesis and analysis of cyclic analogs of angiotensin].
abstract: Five angiotensin cycloanalogues have been synthesised by classical methods of peptide chemistry, cyclisation being carried out via pentafluorophenyl esters. Cycloanalogues (I-IV) with a fixed potential turn in the C-terminal part of the angiotensin molecule inferred on the basis of physico-chemical data do not possess angiotensin-like activity. Compounds (V) with enlarged cycle shows decreased pressor effects as compared with angiotensin. By means of circular dichroism chiroptical properties of the compounds in water and ethanol were examined.
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Antsans
authors.forename: D A
authors.initials: DA
authors.lastname: Bisenietse
authors.forename: I A
authors.initials: IA
authors.lastname: Vosekalna
authors.forename: N V
authors.initials: NV
authors.lastname: Myshliakova
authors.forename: G I
authors.initials: GI
authors.lastname: Chipens
mesh_terms: D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010456:Peptides, Cyclic / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D010456:Peptides, Cyclic; D000804:Angiotensin II
vernacular_title: Sintez i issledovanie tsiklicheskikh analogov angiotenzina.