title: Improvement of learning ability in mice and rats with the root extract of dinh lang (Policias fruticosum L.).
abstract: The effect of Dinh lang root extract (DLRE) on the learning ability of mice and rats was studied. The learning performance in groups of rats belonging to different age-cohorts (4-6 months, 16-18 months and 22-24 months) was studied in the shuttle-box and the age-related decline in the acquisition of a conditioned avoidance response (CAR) was established. Using the passive avoidance test also in mice, an age-related decay in performance, was detected. DLRE treatment 10 mg/kg daily for 3-4 weeks restored the lost ability of 22-24 months old rats to develop CAR, the same treatment significantly improved the performance of young mice and improved retention in both 5-months old and 19-20 months old groups of mice.
authors.affiliation: Department of Pharmacology, Semmelweis University Medical School, Budapest, Hungary.
authors.lastname: Tran Ty Yen
mesh_terms: D000375:Aging / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014744:Vietnam
chemical_list: D010936:Plant Extracts