[Effects of the method and regimen of administration on the carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine in rats].
Peculiarities of carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine administered through a stomach tube on rats were studied in 30 rats given 1-2 ml MNNG dissolved in distilled water (5 mg/ml) through a gastric tube for 2-3 days. The procedure is repeated every 4-10 days. This intermittent carcinogen administration continued until week 20; the animals were killed on week 25. All effective 26 (100%) rats had multiple papillomas and squamous cell carcinomas of the forestomach, 5 (19.2%) had adenomatous hyperplasias and adenocarcinomas of the glandular stomach, 7 (26.9%) had adenocarcinomas and sarcomas of the small intestine.
Kim Do Bin
Sherenesheva
N I
NI
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D007414:Intestinal Neoplasms / Q000139:chemically induced; D007421:Intestine, Small; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced; D013997:Time Factors
D008769:Methylnitronitrosoguanidine
Vliianie sposoba i rezhima vvedeniia na kantserogennyĭ éffekt N-metil-N'-nitro-N-nitrosoguanidina u krys.