title: Appearance of acute gouty arthritis on indium-111-labeled leukocyte scintigraphy.
abstract: Indium-111-labeled leukocyte scintigraphy was performed on a 66-yr-old male with polyarticular acute gouty arthritis. Images revealed intense labeled leukocyte accumulation in a pattern indistinguishable from septic arthritis, in both knees and ankles, and the metatarsophalangeal joint of both great toes, all of which were involved in the acute gouty attack. Joint aspirate as well as blood cultures were reported as no growth; the patient was treated with intravenous colchicine and ACTH for 10 days with dramatic improvement noted. Labeled leukocyte imaging, repeated 12 days after the initial study, revealed near total resolution of joint abnormalities, concordant with the patient's clinical improvement. This case demonstrates that while acute gouty arthritis is a potential pitfall in labeled leukocyte imaging, in the presence of known gout, it may provide a simple, objective, noninvasive method of evaluating patient response to therapy.
authors.affiliation: Andre Meyer Department of Physics-Nuclear Medicine, Mt. Sinai School of Medicine, Mt. Sinai Medical Center, New York, New York 10029.
authors.forename: C J
authors.initials: CJ
authors.lastname: Palestro
authors.forename: A
authors.initials: A
authors.lastname: Vega
authors.forename: C K
authors.initials: CK
authors.lastname: Kim
authors.forename: A J
authors.initials: AJ
authors.lastname: Swyer
authors.forename: S J
authors.initials: SJ
authors.lastname: Goldsmith
mesh_terms: D000208:Acute Disease; D000368:Aged; D015210:Arthritis, Gouty / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008297:Male; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes