Prostaglandin production in response to angiotensin-(1-7) in rabbit isolated vasa deferentia.
Angiotensin-(1-7) is a predominant metabolite of angiotensin I in brain tissue. Its neuromodulatory and prostaglandin (PG) synthesizing capabilities were investigated in the rabbit isolated vas deferens. This metabolite had no significant effect as a neuromodulator, however it increased PGE synthesis in the vasa deferentia with a potency equivalent to that of angiotensin II. The angiotensin-(1-7) has a unique spectrum of activity among the angiotensin peptides to selectively increase PG synthesis. It could be useful in defining the relevance of angiotensin-induced PG synthesis in various systems, particularly in neuronal tissue. Angiotensin-(1-7) potentially could be useful in defining angiotensin receptor subtypes, as well.
Trachte
G J
GJ
Department of Pharmacology, University of Minnesota-Duluth, School of Medicine, MN 55812.
Meixner
K
K
Ferrario
C M
CM
Khosla
M C
MC
D000320:Adrenergic Fibers / Q000502:physiology; D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000805:Angiotensin III / Q000494:pharmacology; D000818:Animals; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011817:Rabbits; D013268:Stimulation, Chemical; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation / Q000378:metabolism
D010446:Peptide Fragments; D011458:Prostaglandins E; D000804:Angiotensin II; D000805:Angiotensin III; D000803:Angiotensin I; C118790:angiotensin I (1-7)