Concentration adjustment of spot samples in analysis of urinary xenobiotic metabolites.
The reliability of the adjustment for the reduction of concentration-dilution effects in urinalysis of spot specimens was evaluated; 95.4% of spot specimens showed a creatinine concentration between 0.5 and 3 g/liter, whereas 59.8% showed a specific gravity between 1.010 and 1.030. Only 6% of the specimens exceeded the specific gravity of 1.035 corresponding to a creatinine concentration of 3 g/liter. Therefore, an acceptable value for specific gravity in spot specimens of 1.035 is proposed. Although either specific gravity or creatinine provides a reliable mean of adjustment, creatinine is preferred because it has fewer physiological confounding factors.
Trevisan
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Istituto di Medicina del Lavoro, Universita' di Padova, Italy.
D000328:Adult; D003404:Creatinine / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013046:Specific Gravity; D015262:Xenobiotics / Q000652:urine*
D015262:Xenobiotics; D003404:Creatinine