Studies on inhibitors of rat mast cell degranulation produced by microorganisms. I. Screening of microorganisms, and isolation and physico-chemical properties of eurocidins C, D and E.
Microorganisms producing anti-inflammatory substances were screened by the inhibitory effect on mast cell degranulation. Three new compounds related to pentaene macrolide eurocidins, eurocidins C, D and E, have been isolated from the culture broth of Streptoverticillium eurocidicum IFO 13491 as the inhibitors. Their molecular weights and molecular formulae were estimated as 781.89 and C39H59NO15 for eurocidin C, 795.92 and C40H61NO15 for eurocidin D, and 779.92 and C40H61NO14 for eurocidin E, respectively.
Nakagomi
K
K
Fermentation Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan.
Takeuchi
M
M
Tanaka
H
H
Tomizuka
N
N
Nakajima
T
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D008970:Molecular Weight; D011090:Polyenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013306:Streptomycetaceae / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011090:Polyenes; C064640:eurocidin C; C064641:eurocidin D; C064642:eurocidin E