Effects of cyclophosphamide and dexamethasone on mast cell populations in Hymenolepis microstoma-infected mice.
Antineoplastic cyclophosphamide (CY) significantly reduced the survival and the weight of Hymenolepis microstoma in mice. Corticosteroid dexamethasone (DEX), on the other hand, did not influence the worm survival and the worms in DEX-treated mice became significantly heavier. Both immunosuppressants abolished H. microstoma-induced bile duct hypertrophy and submucous enteritis and lowered the number of mast cells (MC) in these regions. CY appeared to be more effective in depleting the bile duct MC whereas DEX seemed to affect more the duodenal MC population.
Novak
M
M
Department of Biology, University of Winnipeg, Manitoba, Canada.
Buchannan
L G
LG
Howlader
H
H
D000704:Analysis of Variance; D000818:Animals; D001652:Bile Ducts / Q000473:pathology; D002452:Cell Count; D003520:Cyclophosphamide / Q000494:pharmacology* / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D004386:Duodenum / Q000473:pathology; D006925:Hymenolepiasis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D006926:Hymenolepis / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice
D003907:Dexamethasone; D003520:Cyclophosphamide