title: The effect of instruments for prothrombin time testing on the international normalized ratio.
abstract: Prothrombin time (PT) testing is used for monitoring oral anticoagulant therapy, its result being usually expressed as international normalized ratio (INR). This is done using the international sensitivity index (ISI) specific of thromboplastin employed to carry out the test. In this way a good PT standardization may be achieved although the instruments used to calibrate the thromboplastins might influence the ISI value.
authors.affiliation: Servizio di Immunoematologia e Centro Trasfusionale, Ospedale L. Sacco, Milano.
authors.forename: M
authors.initials: M
authors.lastname: Poggio
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007394:International System of Units; D011517:Prothrombin Time; D011786:Quality Control; D012015:Reference Standards; D013925:Thromboplastin / Q000592:standards
chemical_list: D000925:Anticoagulants; D013925:Thromboplastin