Genetic variation and biochemical properties of esterase-18 (ES-18) in the laboratory rat (Rattus norvegicus): a new locus of esterase cluster 2 in linkage group V.
A new liver-specific rat carboxylesterase isozyme (EC 3.1.1.1) designated esterase-18 (ES-18) is described. Genetic variation of ES-18 was examined in 93 inbred strains and substrains and a structural locus Es-18 was suggested, coding for either the presence (Es-18a) or the absence (Es-18b) of the isozyme. Linkage studies involving two backcross series revealed that Es-18 resides in cluster 2 of LGV. No recombination between Es-18 and other cluster 2 loci was found in 19 lines of two RI strain sets or in the backcross series.
Kluge
R
R
Abteilung für Versuchstierkunde, Medizinischen Fakultät der RWTH Aachen, Bundersrepublik Deutschland.
Hedrich
H J
HJ
von Deimling
O
O
D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D003433:Crosses, Genetic; D008040:Genetic Linkage; D014644:Genetic Variation; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D005810:Multigene Family; D010641:Phenotype; D051381:Rats / Q000235:genetics*
D007527:Isoenzymes; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase