Drug-protein interactions. Comparative studies of levamisole and structural analogs or agents with immunomodulatory effect on the mechanism of protein aggregation.
Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein interaction described as a mechanism of disulfide-sulfhydryl interchange reactions. The groups of atoms involved in the interaction are characterized.
Chicault
M
M
Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
Luu-Duc
C
C
Boucherle
A
A
D001798:Blood Proteins / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002626:Chemistry, Pharmaceutical; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007978:Levamisole / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013773:Tetramisole / Q000097:blood / Q000494:pharmacology
D001798:Blood Proteins; D007166:Immunosuppressive Agents; D007978:Levamisole; D013773:Tetramisole