title: Localization of PDGF-B protein in macrophages in all phases of atherogenesis.
abstract: Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.
authors.affiliation: Department of Pathology, University of Washington, Seattle 98195.
authors.forename: R
authors.initials: R
authors.lastname: Ross
authors.forename: J
authors.initials: J
authors.lastname: Masuda
authors.forename: E W
authors.initials: EW
authors.lastname: Raines
authors.forename: A M
authors.initials: AM
authors.lastname: Gown
authors.forename: S
authors.initials: S
authors.lastname: Katsuda
authors.forename: M
authors.initials: M
authors.lastname: Sasahara
authors.forename: L T
authors.initials: LT
authors.lastname: Malden
authors.forename: H
authors.initials: H
authors.lastname: Masuko
authors.forename: H
authors.initials: H
authors.lastname: Sato
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001161:Arteriosclerosis / Q000378:metabolism*; D015152:Blotting, Northern; D004036:Diet, Atherogenic; D006801:Humans; D007150:Immunohistochemistry; D008254:Macaca nemestrina; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger