[Low density lipoproteins isolated from the blood of patients with ischemic heart disease induce accumulation of lipids in human aortic intima cells].
Very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high density lipoproteins (HDL) were isolated from the blood of healthy subjects and CHD patients. LDL from the blood of healthy individuals did not raise the intracellular lipid values within 24 h of cultivation. During intracellular lipid values within 24 h of cultivation. During the same incubation period. LDL obtained from the blood of CHD patients caused a 2- to 5-fold rise in cholesterol esters as well as a 1.5- to 3-fold rise in free cholesterol and triglycerides, while the intracellular phospholipid levels remained unchanged. In one of the three cases, the ability to raise the intracellular level of cholesterol esters was demonstrated by VLDL (500 micrograms/ml) derived from CHD patients blood. HDL did not affect the lipid levels in smooth muscle cells cultured from unaffected intima. The obtained data suggests that circulating LDL and, possibly, VLDL in the blood of CHD patients are capable of inducing the accumulation of fat in vascular wall cells.
Tertov
V V
VV
Kacharava
A G
AG
Martseniuk
O N
ON
Mukhin
D N
DN
Rogova
E M
EM
Orekhov
A N
AN
D000328:Adult; D001011:Aorta / Q000032:analysis*; D002478:Cells, Cultured; D002784:Cholesterol / Q000032:analysis; D002788:Cholesterol Esters / Q000032:analysis; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000097:blood / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000032:analysis
D002788:Cholesterol Esters; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol
Lipoproteiny nizkoĭ plotnosti, vydelennye iz krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa, vyzyvaiut nakoplenie lipidov v intimal'nykh kletkakh aorty cheloveka.