title: Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study.
abstract: Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.
authors.affiliation: Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
authors.forename: T
authors.initials: T
authors.lastname: Koyama
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Boyadjive
authors.forename: P
authors.initials: P
authors.lastname: Kielholz
authors.forename: M
authors.initials: M
authors.lastname: Gastpar
authors.forename: D
authors.initials: D
authors.lastname: Moussaoui
authors.forename: M
authors.initials: M
authors.lastname: Bouzekraoui
authors.forename: B B
authors.initials: BB
authors.lastname: Sethi
mesh_terms: D000437:Alcoholism / Q000201:enzymology / Q000208:ethnology*; D000445:Aldehyde Oxidoreductases / Q000172:deficiency*; D000431:Ethanol / Q000378:metabolism; D005060:Europe / Q000208:ethnology; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008800:Mexico / Q000208:ethnology; D010679:Philippines / Q000208:ethnology; D012559:Schizophrenia / Q000201:enzymology / Q000208:ethnology; D014944:World Health Organization
chemical_list: D000431:Ethanol; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+)