Evaluation of the developmental effects on mice after prenatal, or pre- and postnatal exposure to 2,3-dimercaptopropane-1-sulfonic acid (DMPS).
The sodium salt of 2,3-dimercaptopropane-1-sulfonic acid (DMPS), a water soluble metal complexing agent, was administered to four groups of pregnant Swiss mice at 0, 70, 210, and 630 mg/kg/day by two dosing schedules: gestation day 14 until birth (prenatal exposure), and gestation day 14 until postnatal day 21 (pre- and postnatal section). Dams were allowed to deliver and the number of live and dead pups recorded. Each pup was sexed and weighed on days 0, 4, 14, and 21. Also, pinna detachment, incisor eruption and eye opening were monitored. No adverse effects on offspring survival or development were evident in either exposures at doses employed in this study. The "no observable effect level" (NOEL) for health hazard to the developing fetus or pup was 630 mg DMPS/kg/day. This dose is much higher than the amounts of DMPS usually administered in human heavy metal poisoning.
Domingo
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, Sant Llorenç, Reus, Spain.
Ortega
A
A
Bosque
M A
MA
Corbella
J
J
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D004112:Dimercaprol; D005260:Female; D007743:Labor, Obstetric / Q000187:drug effects; D007774:Lactation / Q000187:drug effects*; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D014494:Unithiol / Q000008:administration & dosage / Q000633:toxicity*
D004112:Dimercaprol; D014494:Unithiol