[The lymphocyte populations at different stages in the infection caused by the human immunodeficiency virus].
In 58 persons infected with HIV the comparative study of the content of immunocompetent cells was carried out by the methods of rosette formation and immunofluorescence with the use of monoclonal antibodies. An increase in the content of rosette-forming cells (RFC), such as active E-RFC, E-RFC, theophylline-resistant E-RFC and M-FRC, in asymptomatic seropositive persons was established. At this stage of the disease the amount of lymphocytes T4 and T8 and their ratio underwent no essential changes. At the stage of lymphoadenopathy an increase in the content of lymphocytes T8, more pronounced in patients with secondary infectious lesions, was noted. At this stage a decrease in T4/T8 ratio appeared for the first time. A high level of rosette-forming lymphocytes was still observed both at this period and at the period of clinically developed AIDS, while the level of lymphocytes T4 sharply dropped in such patients.
Pokrovskiĭ
V V
VV
Gabrilovich
D I
DI
Serebrovskaia
L V
LV
Sundukova
E Iu
EIu
Semashko
M I
MI
Khabarova
V V
VV
Shalygina
N B
NB
D000386:AIDS-Related Complex / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000349:Africa / Q000208:ethnology; D002353:Carrier State / Q000276:immunology; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D014586:USSR
Populiatsii limfotsitov na razlichnykh stadiiakh infektsii, vyzvannoĭ virusom immunodefitsita cheloveka.