title: Quantitative distributions of aspartate aminotransferase and glutaminase activities in the guinea pig cochlea.
abstract: Distributions of aspartate aminotransferase and glutaminase activities in the guinea pig cochlea have been examined with use of quantitative microchemical techniques to evaluate their roles in cochlear energy metabolism and neurotransmission. Other enzyme activities analyzed were those of choline acetyltransferase and malate dehydrogenase. It is concluded that aspartate aminotransferase activity appears to be especially concerned with cochlear energy metabolism, while glutaminase activity may function in transmitter metabolism in the guinea pig cochlea. Neither enzyme shows a clear association with the olivocochlear bundle.
authors.affiliation: Department of Physiology, Oral Roberts University, Tulsa, Oklahoma.
authors.forename: G J
authors.initials: GJ
authors.lastname: Wiet
authors.forename: D A
authors.initials: DA
authors.lastname: Godfrey
authors.forename: J A
authors.initials: JA
authors.lastname: Rubio
authors.forename: C D
authors.initials: CD
authors.lastname: Ross
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D002795:Choline O-Acetyltransferase / Q000032:analysis; D003051:Cochlea / Q000032:analysis / Q000201:enzymology* / Q000378:metabolism; D004734:Energy Metabolism; D005972:Glutaminase / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008291:Malate Dehydrogenase / Q000032:analysis; D008297:Male; D009925:Organ of Corti / Q000032:analysis / Q000033:anatomy & histology / Q000201:enzymology
chemical_list: D008291:Malate Dehydrogenase; D002795:Choline O-Acetyltransferase; D001219:Aspartate Aminotransferases; D005972:Glutaminase