Lack of interaction between disulfiram and alprazolam in alcoholic patients.
Certain interactions between disulfiram and benzodiazepines, especially diazepam and chlordiazepoxide, have previously been reported. The influence of disulfiram on the pharmacokinetics of alprazolam, a triazolobenzodiazepine, metabolized by hepatic microsomal oxidation, has been evaluated in 11 chronic alcoholic patients (6 males, 5 females) undergoing treatment for the alcohol withdrawal syndrome. Each patient received alprazolam 2 mg on the first day (control) followed by two weeks of treatment with disulfiram 0.5 g/d, and then further oral dose of alprazolam 2 mg. No significant change was found in any of the kinetic parameters. Thus, a therapeutic dose of disulfiram did not significantly alter the clearance or half-life of alprazolam in chronic alcoholic patients.
Diquet
B
B
Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpetrière, Paris, France.
Gujadhur
L
L
Lamiable
D
D
Warot
D
D
Hayoun
H
H
Choisy
H
H
D000328:Adult; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000525:Alprazolam / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D004221:Disulfiram; D000525:Alprazolam