Appearance during chick embryogenesis of vitamin D-dependent calcium-binding protein (calbindin-D28K).
The appearance of the vitamin D-dependent calcium-binding protein (calbindin-D28K) in embryonic chick tissues was determined using a sensitive immunohistochemical assay to elucidate the possible role of calbindin-D28K during embryogenesis. This protein first occurs in renal, cerebellar and intestinal cells during the final stages of maturation and/or differentiation. It is during this period of their development that these tissues become functional. On the basis of our observations, we suggest that the onset of cell function may be coupled with the appearance of calbindin-D28K.
Opperman
L A
LA
Department of Paediatrics, University of the Witwatersrand, Medical School, Johannesburg, South Africa.
Ross
F P
FP
Stein
B
B
Hirsch
G
G
D000818:Animals; D064026:Calbindins; D002117:Calcitriol / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002642:Chick Embryo / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013997:Time Factors
D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D002117:Calcitriol