Influence of clonidine, methyldopa and propranolol on acute toxicity of fenitrothion in mice.
The effect of pretreatment with clonidine, methyldopa and propranolol, and of atropine was studied in mice on acute toxicity of fenitrothion, the active ingredient of TIK-20. Atropine significantly decreased and propranolol somewhat decreased the fenitrothion induced death in mice. Clonidine and methyldopa somewhat increased the percentage mortality due to fenitrothion.
Valecha
N
N
Department of Pharmacology, Maulana Azad Medical College, New Delhi.
Prabhu
S
S
Mehta
V L
VL
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D005278:Fenitrothion / Q000633:toxicity*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*
D008750:Methyldopa; D001285:Atropine; D011433:Propranolol; D003000:Clonidine; D005278:Fenitrothion