title: Behavior of genetic markers in recipients after bone marrow transplantation and problems in forensic medicine.
abstract: The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.
authors.affiliation: Department of Legal Medicine and Human Genetics, Jichi Medical School, Tochigi, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ikemoto
authors.forename: E
authors.initials: E
authors.lastname: Kajii
authors.forename: S
authors.initials: S
authors.lastname: Tsuchida
authors.forename: Y
authors.initials: Y
authors.lastname: Amemiya
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000032:analysis; D005554:Forensic Medicine; D005819:Genetic Markers / Q000032:analysis*; D006801:Humans; D010641:Phenotype; D012463:Saliva / Q000032:analysis; D014170:Transformation, Genetic
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers