Effects of indomethacin on adhesion formation after repair of zone II tendon lacerations in the rabbit.
The flexor digitorum profundus tendon of the second medial toe of the hind foot was completely divided and repaired in zone II in 30 New Zealand white rabbits. Half of the animals received indomethacin solution (1 mg/kg/day) injected subcutaneously 2 hours before operation and daily for 4 weeks. The remaining 15 animals received daily injection of the same volume of saline solution. At 4 weeks the animals were killed and measurements were made of the angular motion of the distal interphalangeal joint and the excursion of the tendon. The animals treated with indomethacin had a greater tendon excursion and angular rotation of the joint than the control animals, implying a suppression of adhesions.
Szabo
R M
RM
Department of Orthopaedic Surgery, University of California, Davis, Sacramento.
Younger
E
E
D000818:Animals; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D012399:Rotation; D013708:Tendon Injuries / Q000503:physiopathology*; D014033:Toe Joint / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects*
D007213:Indomethacin