Hepatic branch vagotomy attenuates the feeding response to 2-deoxy-D-glucose in rats.
The effect of hepatic branch vagotomy on the feeding response induced in rats by intraperitoneally injected 2-deoxy-D-glucose (2-DG) was tested. Injections were given 1 h after onset of the dark phase, and immediately [corrected] after the rats had ingested a meal. 2-DG produced a smaller feeding response in hepatic branch-vagotomized rats compared with that in sham-vagotomized rats. This finding suggests that hepatic glucoreceptors with vagal afferent fibres are involved in the feeding response to glucose deprivation.
Delprete
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Institute of Veterinary Physiology, University of Zürich, Switzerland.
Scharrer
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D000818:Animals; D003624:Darkness; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000294:innervation*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
D003837:Deoxy Sugars; D003847:Deoxyglucose