Effects of MPTP on the fine structure of neurons in substantia nigra of dogs.
This study evaluates fine structural changes in neurons from pars compacta of substantia nigra in dogs 1 and 4 days after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The toxin induced a disruption and high amplitude swelling of mitochondria, and dispersion of rough endoplasmic reticulum at 4 days. Mitochondria in dendrites were less damaged than those in the soma. Swelling of myelinated axons in the nigrostriatal pathway was evident at 1 and 4 days after injection. Similar morphologic changes are produced by axotomy and inhibitors of mitochondrial function.
Rapisardi
S C
SC
Department of Anatomy, Howard University College of Medicine, Washington, D.C. 20059.
Warrington
V O
VO
Wilson
J S
JS
D000818:Animals; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D020267:MPTP Poisoning; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology*