title: [A model of mononuclear phagocyte block using carrageenan-kappa].
abstract: Experiments conducted on CBA mice to study the effect of intraperitoneal injections of 1.0, 2.5, 5.0, and 10 mg/mouse of carrageenan-kappa (Sigma, USA) on the ingesting capacity of mononuclear phagocytes allowed the authors to suggest a model of 10- and 24-hour macrophage block. Doses of 2.5 and 5 mg/mouse are most advisable. Monocytopenia was encountered in peripheral blood in block of macrophages. The depth and duration of the macrophage block can be controlled according to the response of peripheral blood monocytes of mice given carrageenan-kappa.
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'berg
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: T V
authors.initials: TV
authors.lastname: Guseva
authors.forename: T V
authors.initials: TV
authors.lastname: Shevchenko
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D002351:Carrageenan
vernacular_title: Model' blokady mononuklearnykh fagotsitov s ispol'zovaniem karraginana kappa.