[Interaction of xenobiotics and the body from the viewpoint of biokinetics].
On the basis of biokinetic principles with account of the concept of receptors in toxicology there were derived equations of concentration/time/effect relationship to describe both nonreversible and reversible interaction of xenobiotics and receptors in a critical organ regarded as a unique compartment responsible for xenobiotic toxic effect. An example of calculating xenoreceptor concentration in a critical organ was given.
Pavlov
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D006801:Humans; D007700:Kinetics; D007928:Lethal Dose 50; D008954:Models, Biological; D015262:Xenobiotics
D015262:Xenobiotics
Vzaĭmodeĭstvie ksenobiotikov i organizma s pozitsiĭ biokinetiki.