Use of spironolactone in treatment of hirsutism.
Spironolactone (Aldactone), 100 mg to 200 mg daily, has antiandrogenic effects that may enhance treatment of androgen-excess syndromes, particularly severe hirsutism. Combination therapy with an oral contraceptive or with dexamethasone appears to have a beneficial effect. Side effects are transient. The drug should be avoided during pregnancy and in women who have a family history of breast cancer, although there is no proven association between spironolactone and breast malignancy.
Cumming
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Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Canada.
D003276:Contraceptives, Oral / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use*
D003276:Contraceptives, Oral; D013148:Spironolactone; D003907:Dexamethasone