title: Converting enzyme inhibition by enalapril in experimental heart failure.
abstract: We analyzed the effect of enalapril (0.1 mg/kg p.o. twice daily) on plasma electrolytes, urea, and creatinine in low cardiac output failure. In 14 male dogs implanted with chronic instrumentation, tachycardia was induced by ventricular pacing (265 impulses/min., 10-14 days). In 7 untreated dogs, pacing progressively lowered aortic flow by 44% and induced hyponatremia and elevations of plasma urea, creatinine, and potassium. Treatment with enalapril (n = 7) during pacing reduced the decrease in aortic flow by 33% and prevented changes in plasma urea, potassium, and sodium. We conclude that this is due to enalapril-induced retardation of heart failure progression.
authors.affiliation: Institute of Applied Physiology, University of Freiburg, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Holtz
authors.forename: T
authors.initials: T
authors.lastname: Munzel
authors.forename: O
authors.initials: O
authors.lastname: Sommer
authors.forename: E
authors.initials: E
authors.lastname: Bassenge
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002303:Cardiac Output, Low / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D002304:Cardiac Pacing, Artificial; D003404:Creatinine / Q000097:blood; D004285:Dogs; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology*; D007010:Hyponatremia / Q000209:etiology*; D008297:Male; D008954:Models, Biological; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013610:Tachycardia / Q000209:etiology; D014508:Urea / Q000097:blood
chemical_list: D004656:Enalapril; D014508:Urea; D012964:Sodium; D003404:Creatinine; D011188:Potassium