title: Barotrauma and microvascular injury in lungs of nonadult rabbits: effect of ventilation pattern.
abstract: To study the pulmonary microvascular injury produced by ventilation barotrauma, the isolated perfused lungs of 4 to 6-wk-old New Zealand white rabbits were ventilated by one of the following methods: peak inspiratory pressure (PIP) 23 cm H2O, gas flow rate 1.1 L/min (group 1); PIP 27 cm H2O, gas flow rate 6.9 L/min (group 2); PIP 50 cm H2O, gas flow rate 1.9 L/min (group 3); or PIP 53 cm H2O, gas flow rate 8.3 L/min (group 4). Microvascular permeability was assessed using the capillary filtration coefficient (Kfc) before and 5, 30, and 60 min after a 15-min period of ventilation. Baseline Kfc was not significantly different between groups. A significant increase over the baseline Kfc was noted at 60 min in group 2 and in all postventilation Kfc values in groups 3 and 4 (p less than .05). Group 1 Kfc values did not change significantly after ventilation. At all post-ventilation times, values for Kfc were significantly greater in groups 3 and 4 than in group 1 (p less than .05). Group 4 Kfc values were significantly greater than those in group 2 at 5 and 30 min postventilation. These data indicate that high PIP, and to a lesser extent, high gas flow rates cause microvascular injury in the compliant nonadult lung and suggest that the combination of high PIP and high gas flow rates are the most threatening to microvascular integrity.
authors.affiliation: Department of Pediatrics, University of South Alabama, Mobile 36617.
authors.forename: K J
authors.initials: KJ
authors.lastname: Peevy
authors.forename: L A
authors.initials: LA
authors.lastname: Hernandez
authors.forename: A A
authors.initials: AA
authors.lastname: Moise
authors.forename: J C
authors.initials: JC
authors.lastname: Parker
mesh_terms: D000818:Animals; D001469:Barotrauma / Q000209:etiology / Q000503:physiopathology*; D002199:Capillary Permeability; D066298:In Vitro Techniques; D008168:Lung / Q000098:blood supply / Q000503:physiopathology; D055370:Lung Injury; D011312:Pressure; D011817:Rabbits; D012121:Respiration, Artificial / Q000009:adverse effects*