Targeting of urea stibamine encapsulated in liposomes to reticuloendothelial system for the treatment of experimental leishmaniasis.
The antileishmanial antimonial drug urea stibamine was encapsulated in mannosylated and nonmannosylated liposomes and was tested against experimental leishmanial infection in hamsters. The study demonstrated that liposome encapsulation of urea stibamine enhanced its effectiveness, an effect which was greater when mannosylated liposomes were used.
Das
N
N
Leishmania Group, Indian Institute of Chemical Biology, Calcutta.
Mahato
S B
SB
Naskar
K
K
Ghosh
D K
DK
Basu
M K
MK
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006224:Cricetinae; D004337:Drug Carriers; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008081:Liposomes; D008358:Mannose; D008647:Mesocricetus; D012157:Mononuclear Phagocyte System; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000627:therapeutic use; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D004337:Drug Carriers; D008081:Liposomes; D009942:Organometallic Compounds; D014508:Urea; C053921:urea stibamine; D008358:Mannose