Multiple VLA antigens on a subset of melanoma clones.
A panel of 19 melanoma clones was characterized by fluorescence activated cell sorter analysis for the expression of distinct integrin receptors in the very late activation antibody subfamily. A group of five melanoma clones (2/4, 2/14, 2/17, 2/51, and 2/60) was identified that shared coordinate expression of multiple VLA antigens. These same clones were more susceptible, in terms of lytic units, to cell-mediated lysis and also expressed the lower melanin content per cell in the panel. The data suggest that in a heterogeneous neoplastic population, distinct features such as susceptibility to cell-mediated lysis and expression of receptors for extracellular components are variables preferentially associated with cells in an early stage of differentiation.
Anichini
A
A
Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy.
Mortarini
R
R
Berti
E
E
Parmiani
G
G
D000951:Antigens, Neoplasm / Q000032:analysis*; D002454:Cell Differentiation; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D005434:Flow Cytometry; D006801:Humans; D016023:Integrins / Q000032:analysis*; D008543:Melanins / Q000032:analysis; D008545:Melanoma / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology
D000951:Antigens, Neoplasm; D016023:Integrins; D008543:Melanins