title: Lack of interaction between disulfiram and alprazolam in alcoholic patients.
abstract: Certain interactions between disulfiram and benzodiazepines, especially diazepam and chlordiazepoxide, have previously been reported. The influence of disulfiram on the pharmacokinetics of alprazolam, a triazolobenzodiazepine, metabolized by hepatic microsomal oxidation, has been evaluated in 11 chronic alcoholic patients (6 males, 5 females) undergoing treatment for the alcohol withdrawal syndrome. Each patient received alprazolam 2 mg on the first day (control) followed by two weeks of treatment with disulfiram 0.5 g/d, and then further oral dose of alprazolam 2 mg. No significant change was found in any of the kinetic parameters. Thus, a therapeutic dose of disulfiram did not significantly alter the clearance or half-life of alprazolam in chronic alcoholic patients.
authors.affiliation: Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpetrière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Diquet
authors.forename: L
authors.initials: L
authors.lastname: Gujadhur
authors.forename: D
authors.initials: D
authors.lastname: Lamiable
authors.forename: D
authors.initials: D
authors.lastname: Warot
authors.forename: H
authors.initials: H
authors.lastname: Hayoun
authors.forename: H
authors.initials: H
authors.lastname: Choisy
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000525:Alprazolam / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004221:Disulfiram / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004221:Disulfiram; D000525:Alprazolam