title: [Capacity of opsonic recognition of polymorphonuclear neutrophils in malnourished children].
abstract: The opsonic recognition capacity of polymorphonuclear neutrophils (PMNs) was evaluated in 19 noninfected children (13 eutrophic and 6 malnourished) and 22 infected children (10 eutrophic and 12 malnourished) by determining the rosette-formation capacity of the PMNs with sheep erythrocytes. After evaluating the percentage of rosette-forming neutrophils (RFN), we did not observe significant differences between the PMNs from eutrophic children and those from noninfected malnourished children (70.2 +/- 5% vs 67 +/- 3% respectively, P greater than 0.5). In contrast, the opsonic recognition capacity of PMNs from children with acute bacterial infections was significantly lower in the eutrophic (54.4 +/- 5.8%, P less than 0.05) and even more accentuated in the malnourished children (42.8 +/- 5%, P less than 0.01) when compared to the noninfected children. These results indicate that the opsonic recognition capacity of the PMNs decreases during bacterial infections. Due to the critical role of the PMNs as a mechanism of defense against infection, the greater decrease of the opsonic recognition capacity of the PMNs observed in infected malnourished children could be yet another explanation for the greater morbidity and mortality from the infectious processes observed in malnourished children.
authors.affiliation: Departamento de Enfermedades Infecciosas y Parasitarias, Hospital Infantil de México Federico Gómez, D.F.
authors.forename: C
authors.initials: C
authors.lastname: Soria-Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Arbo-Sosa
authors.forename: G
authors.initials: G
authors.lastname: Basurto-Celaya
authors.forename: J I
authors.initials: JI
authors.lastname: Santos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D009748:Nutrition Disorders / Q000276:immunology*; D010587:Phagocytosis; D012397:Rosette Formation
vernacular_title: Capacidad de reconocimiento opsónico de los neutrófilos polimorfonucleares de niños desnutridos.