title: Mammary tumor inhibiting properties of the (S,S)-configurated [1,2-bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) complex.
abstract: [(S,S)-1,2-Bis(4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) shows a strong and dose-dependent effect on the hormone-dependent MXT mammary carcinoma of the mouse. The R,R/S,S-configurated compound is markedly less active.
authors.affiliation: Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Universität Regensburg, FRG.
authors.forename: T
authors.initials: T
authors.lastname: Spruss
authors.forename: R
authors.initials: R
authors.lastname: Gust
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: H
authors.initials: H
authors.lastname: Schönenberger
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C059728:dichloro(1,2-bis(3-hydroxyphenyl)ethylenediamine)platinum II