[Subcellular basis of disorders of the contractile capacity of the heart in L-thyroxine-induced thyrotoxicosis].
In experiments on dogs, the authors examined the functional activity of three cardiomyocyte systems responsible for contraction-relaxation (the systems of contractile proteins, calcium transport and energy supply) in the dynamics of L-thyroxine-induced toxicosis. A fall in the capacity of the contractile protein system to generate energy and to perform was shown to play the leading role in decrease of myocardial reserve forces and reduction in cardiac contractility. There was a drop in the intensity of calcium transport through the membranes of the sarcoplasmic reticulum and mitochondria and a deficiency of the direct energy source for contraction only in the late period of the disease.
Karsanov
N V
NV
Melashvili
N O
NO
Khugashvili
Z G
ZG
Mamulashvili
L D
LD
Azrumelashvili
M I
MI
Khaindrava
G K
GK
Kapanadze
R V
RV
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006333:Heart Failure / Q000209:etiology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D009206:Myocardium / Q000648:ultrastructure*; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000502:physiology*; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D013974:Thyroxine
D013974:Thyroxine
Subkletochnye osnovy narusheniia sokratitel'noĭ sposobnosti serdtsa pri L-tiroksinovom toksikoze.