title: Responsiveness of subcutaneous human glioma xenografts to various antitumor agents.
abstract: Responsiveness of seven human glioma xenografts to seven antitumor agents was investigated by an sc-iv system and the efficacies of these agents against human glioma were evaluated in terms of response rate. When their maximum tolerated doses were used, experimental response rates of nimustine (ACNU), vincristine (VCR), adriamycin (ADR) and vinblastine (VLB) were as high as 86-100%, while that of mitomycin (MMC) was 57%, and those of 5-fluorouracil (5-FU) and methotrexate (MTX) were 0%. On the other hand, when the doses pharmacokinetically equivalent to their clinical doses were employed, the response rate of ADR was the highest, followed by VCR and ACNU in this order. These results suggest that gliomas are significantly responsive to various antitumor agents in this sc-iv system.
authors.affiliation: Central Institute for Experimental Animals, Kawasaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maruo
authors.forename: Y
authors.initials: Y
authors.lastname: Ueyama
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: R
authors.initials: R
authors.lastname: Emura
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: O
authors.initials: O
authors.lastname: Nakamura
authors.forename: O
authors.initials: O
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Nomura
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents