[Effects of dauricine on His-bundle electrogram and interaction with other drugs in anesthetized rabbits].
Dauricine was shown to prolong the HBE A-H, H-V intervals and the V width of anesthetized rabbits in a dose-dependent manner. Dauricine 2.5, 5 and 7.5 mg/kg iv increased the A-H interval by 11 +/- 6, 21 +/- 12 and 33 +/- 14%; prolonged the H-V interval by 22 +/- 9, 34 +/- 22 and 51 +/- 16%; and widened the V by 14 +/- 6, 22 +/- 12 and 27 +/- 11%, respectively. The effect of dauricine on the H-V interval was greater than on the A-H interval. Influence of lidocaine on the His-bundle electrogram was not significant. The effect of dauricine on the H-V interval was weakened when administered in combination with lidocaine (p less than 0.05). Dauricine 7.5 mg/kg prolonged the A-H interval at all stimulation frequencies (300, 335, 375, 430 beats/min). Dauricine increased the atrial effective refractory period (AERP) and the atrial-ventricular (A-V) node functional refractory period (AVNFRP) of the rabbits in dose-dependent manner. Isoprenaline 10 micrograms/kg iv shortened the A-H, H-V intervals and V width, and atropine 3 mg/kg iv partially reduced the A-H interval prolonged by dauricine.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhu
J Q
JQ
Department of Clinical Pharmacology, Tongji Medical University, Hankou.
Zeng
F D
FD
Hu
C J
CJ
D000470:Alkaloids; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001285:Atropine / Q000494:pharmacology; D044182:Benzylisoquinolines; D002036:Bundle of His / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006329:Heart Conduction System / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D007546:Isoquinolines / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D044005:Tetrahydroisoquinolines
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D044182:Benzylisoquinolines; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D001285:Atropine; C035934:dauricine; D008012:Lidocaine; D007545:Isoproterenol