Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats.
When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocyte acetyl cholinesterase activity. Irrespective of the route of administration, MIC also caused severe hypothermia, which was not ameliorated by prior administration of atropine sulphate. Acute toxic effects of MIC are essentially similar by either route except for the intensity of the effects.
Jeevaratnam
K
K
Division of Pharmacology and Toxicology, Defence R&D Establishment, Gwalior, India.
Vijayaraghavan
R
R
Kaushik
M P
MP
Vaidyanathan
C S
CS
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003485:Cyanates / Q000633:toxicity*; D006943:Hyperglycemia / Q000139:chemically induced*; D007035:Hypothermia / Q000139:chemically induced*; D017953:Isocyanates; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000139:chemically induced*
D001786:Blood Glucose; D003485:Cyanates; D017953:Isocyanates; C008461:methyl isocyanate