Hypertension and cerebral arteries: relationship to disruption of the blood-brain barrier.
This study was performed to determine whether structural changes in cerebral arterioles could account for differences in susceptibility of the blood-brain barrier to acute hypertensive disruption between hypertensive and normotensive animals. We studied spontaneously hypertensive rats (SHR), 3 other models of hypertension and their normotensive controls. The age and duration of hypertension of the rats were matched to an earlier study showing that protection of the blood-brain barrier was usually found in rats with chronic hypertension. We measured the dimensions of fixed pial arterioles and minimal cerebrovascular resistance produced by bicuculline. Minimal cerebrovascular resistance was not different between the groups of animals. There were no differences in the area of the media of pial arterioles between any of the groups. In addition, we examined the possibility that sympathetic nerves might affect cerebrovascular resistance during bicuculline in SHR. The presence of sympathetic nerves in SHR, but not WKY, reduced the degree of cerebral vascular dilation during bicuculline. From these data we conclude that 1) structural changes in cerebral vessels do not account for protection of the blood-brain barrier in rats with a moderate duration of hypertension and 2) sympathetic nerves may have an exaggerated effect on cerebral vessels of SHR.
Werber
A H
AH
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Fitch-Burke
M C
MC
Tobin
P C
PC
D000818:Animals; D001160:Arterioles / Q000473:pathology; D001640:Bicuculline; D001812:Blood-Brain Barrier / Q000502:physiology*; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology*; D015171:Ganglionectomy; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D006984:Hypertrophy / Q000473:pathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D001640:Bicuculline