title: [A case of primary anterior mediastinal choriocarcinoma].
abstract: A 25-year-old man was admitted to our hospital because of hemosputum and abnormal shadows on chest X-ray film. The chest film showed a mass shadow located in the right hilum and multiple coin lesions in bilateral lung fields. The chest CT scan showed a bulky mass sized 7 cm X 6 cm at the anterior mediastinum. This case was suspected to be choriocarcinoma because he was young, it was rapidly progressive and also because serum LDH and beta-HCG values were raised. The specimens obtained by surgical biopsy showed HCG-stain positive syncytiotrophoblasts. Cancer chemotherapy was started with CDDP and other anti-cancer drugs, but he succumbed about 3 months after admission. Autopsy findings showed no scar formation of his testes, and the primary lesion was finally diagnosed to be in the anterior mediastinum. Extra-gonadal choriocarcinoma is rare, and beta-HCG is very useful for its diagnosis and the follow-up of the clinical course.
authors.affiliation: Department of Internal Medicine, Showa University Fujigaoka Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Narushima
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumura
authors.forename: H
authors.initials: H
authors.lastname: Ootsuka
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Akisawa
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: E
authors.initials: E
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D002822:Choriocarcinoma / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*