Lithium acetate gastrointestinal diffusion system. Part 2: Lithium acetate multi-unit gastrointestinal diffusion system: preparation and release rate studies.
The method of obtaining the multi-unit gastrointestinal diffusion system (m-GDS), containing lithium acetate, consists in encapsulating the lithium acetate in a form of microballs and thereafter coating the resulting microballs with a porous membrane which controls the diffusion rats of the drug. For the coating, a water-insoluble polymer (cellulose acetate) and two types of polymer-modifying agents (cetyl alcohol and shellac) were used. In this paper in vitro studies of drug release from the unit in relation to the microballs' coating and mass, and exposed surface area of the capsules are presented. Most in vitro systems provide zero-order dry delivery by appropriate selection of manufacturing parameters.
Jedras
Z
Z
Department of Pharmaceutical Technology, Medical Academy of Gdańsk, Poland.
Janicki
S
S
D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004058:Diffusion; D005079:Excipients; D005233:Fatty Alcohols; D006863:Hydrogen-Ion Concentration; D008094:Lithium / Q000008:administration & dosage*; D008567:Membranes, Artificial; D008863:Microspheres
D003692:Delayed-Action Preparations; D005079:Excipients; D005233:Fatty Alcohols; D008567:Membranes, Artificial; C005062:acetylcellulose; D002482:Cellulose; C005031:cetyl alcohol; D008094:Lithium