title: [Electron microscopic and morphometric research on the development of the outer segments of the photoreceptor cells in mutant Campbell rats with hereditary retinal dystrophy].
abstract: Development of rod outer segment (ROS) in the posterior area of the retina in normal (GR) and mutant Campbell rats with inherited retinal dystrophy was studied using transmission electron microscopy and morphometry. In both strains of rats primitive cilia appear first after birth and their number progressively increases up to postnatal day 9. The first ROS membrane disks (MD) appear at postnatal day 5. Originally MD are randomly oriented but later they acquire a regular arrangement. At day 7 MD occupy about 14% area of posterior retina in transverse sections in Campbell rats versus 7% in normal animals. By day 9 MD occupy about 35% area in the same region of the retina in both lines of rats. The retina of 15-day-old rats possesses the definitive number of differentiated ROS. The data obtained show that during the period between birth and eyelid opening ROS morphogenesis in Campbell rats is not slow or disturbed as compared with that in normal rats.
authors.forename: V A
authors.initials: VA
authors.lastname: Poplinskaia
authors.forename: O G
authors.initials: OG
authors.lastname: Stroeva
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D008854:Microscopy, Electron; D010786:Photoreceptor Cells / Q000648:ultrastructure*; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D051381:Rats; D011922:Rats, Mutant Strains / Q000033:anatomy & histology*; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology*; D012374:Rod Cell Outer Segment / Q000254:growth & development / Q000648:ultrastructure*
vernacular_title: Elektronno-mikroskopicheskoe i morfometricheskoe issledovanie razvitiia naruzhnykh segmentov fotoretseptornykh kletok u mutantnykh krys Campbell s nasledstvennoĭ distrofieĭ setchatki.