title: [Evaluation of catalytic activity of multiple forms of cytochrome P-450 in liver microsomes of Wistar rats by androstenedione metabolism].
abstract: The synthesis of androstenedione (AD) metabolites in liver microsomes of control and phenobarbital (PB)-induced male and female Wistar rats was studied. In liver microsomes of non-induced male rats the predominant formation of 16 alpha-hydroxyandrostenedione was observed, whereas in females the predominant form was the 7 alpha-metabolite. Induction of animals of both sexes with PB was accompanied by an increase in the 16 beta-hydroxylase activity. The dynamics of synthesis of other AD metabolites specifically produced by such cytochrome P-450 forms as P-450a, P-450h and P-450p was investigated. The specificity of metabolism of androstenedione by multiple forms of cytochrome P-450 is postulated.
authors.forename: O G
authors.initials: OG
authors.lastname: Khatsenko
authors.forename: L F
authors.initials: LF
authors.lastname: Guliaeva
authors.forename: V M
authors.initials: VM
authors.lastname: Mishin
authors.forename: V V
authors.initials: VV
authors.lastname: Liakhovich
mesh_terms: D000735:Androstenedione / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction; D005260:Female; D006900:Hydroxylation; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007527:Isoenzymes; D000735:Androstenedione; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
vernacular_title: Otsenka kataliticheskoĭ aktivnosti mnozhestvennykh form tsitokhroma P-450 v mikrosomakh pecheni krys linii Vistar po metabolizmu androstendiona.