Synthesis of novel 2-substituted quinoline derivatives: antimicrobial, inotropic, and chronotropic activities.
Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3-(1,3-dioxolan-2-yl)-2-substituted thiocarbamoyl-hydrazinoquinolines with different alpha-halocarbonyl compounds. These series are: 3-(1,3-dioxolan-2-yl)-2-(3-substituted-4-phenylthiazolin-2-y lidene) hydrazinoquinolines; 3-(1,3-dioxolan-2-yl)-2-(3-substituted-5-ethoxycarbonyl- 4-methylthiazoline-2-ylidene)hydrazinoquinolines and 3-(1,3-dioxolan-2-yl)-2- (3-substituted-4-thiazolidinon-2-yl)hydrazinoquinolines. The active methylene group of the latter series was used for the preparation of their arylidene derivatives. The antimicrobial as well as inotropic and chronotropic activities of the prepared compounds were studied.
Farghaly
A M
AM
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
Habib
N S
NS
Khalil
M A
MA
el-Sayed
O A
OA
Bistawroos
A E
AE
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001001:Anura; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009200:Myocardial Contraction / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D042462:4-Quinolones; D000890:Anti-Infective Agents; D011804:Quinolines