Postsynaptic long-term enhancement (LTE) by dopamine may be mediated by Ca2+ and calmodulin.
Long-term enhancement (LTE), of postsynaptic slow depolarizing responses to a muscarinic agonist (MCh), follows a brief exposure of the rabbit superior cervical ganglion to another transmitter, dopamine (DA). Either reduction of external Ca2+ (to 1.0 mM or 0.2 mM) or presence of a specific calmodulin antagonist (calmidazolium at 5 microM) blocked DA induction of this LTE. However, unlike LTP in hippocampus, induction of LTE is not mediated by depolarization-dependent influx of Ca2+.
Mochida
S
S
Department of Physiology, Tokyo Medical College, Japan.
Libet
B
B
D000200:Action Potentials / Q000187:drug effects; D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D011817:Rabbits
D002147:Calmodulin; D007093:Imidazoles; C031938:calmidazolium; D002118:Calcium; D004298:Dopamine