Normocalcemic tetany abolished by calcium infusion.
Tetany is a disorder of increased neuronal excitability usually associated with hypocalcemia. We studied a patient with typical tetanic cramps that responded to intravenous infusion of calcium despite normal serum concentrations of total and ionized calcium. Three generations were affected by similar symptoms, suggesting that this is a dominantly inherited disorder of neuronal hyperirritability.
Day
J W
JW
Department of Neurology, University of California, San Francisco 94143-0114.
Parry
G J
GJ
D000200:Action Potentials; D000328:Adult; D002118:Calcium / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009132:Muscles / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology*; D009431:Neural Conduction / Q000187:drug effects; D013746:Tetany / Q000188:drug therapy* / Q000503:physiopathology
D002118:Calcium