Naloxone induces miosis in normal subjects.
In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0.4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0.4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response.
Loimer
N
N
Psychiatrische Universitätsklinik Wien, Vienna, Austria.
Schmid
R
R
Grünberger
J
J
Linzmayer
L
L
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D015877:Miosis / Q000139:chemically induced*; D009270:Naloxone / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000503:physiopathology; D011680:Pupil / Q000187:drug effects
D009270:Naloxone