title: Skeletal complications of type I Gaucher disease: the magnetic resonance features.
abstract: Abnormalities on magnetic resonance imaging (MRI) are reported in six individuals with various skeletal complications of type I Gaucher disease. The changes were a nonhomogeneous reduction in both T1 and T2 marrow signals with increased T2 signals during avascular episodes. MRI proved an excellent technique for the assessment of bone marrow changes in Type I Gaucher disease and for assessing avascular complications. It was not able to differentiate between pseudo-osteomyelitis and pyogenic osteomyelitis without clinical correlation. The problems studied included the extent of intramedullary Gaucher cell infiltration, avascular necrosis of femoral heads, assessment of bone pain from pseudo-osteomyelitis and the relationship of skeletal disease to splenectomy.
authors.affiliation: Paediatric Radiology, Red Cross Children's Hospital, University of Cape Town, South Africa.
authors.forename: B J
authors.initials: BJ
authors.lastname: Cremin
authors.forename: H
authors.initials: H
authors.lastname: Davey
authors.forename: J
authors.initials: J
authors.lastname: Goldblatt
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000175:diagnosis* / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D005190:Family; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000209:etiology; D005776:Gaucher Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis / Q000209:etiology