Does a 2----5 beta-turn structure exist in enkephalins? Study of a fully protected Leu-enkephalin in organic solution by 17O-NMR.
The 17O chemical shifts of the Gly-2 and Gly-3 oxygens of a fully protected Leu-enkephalin were measured to be identical in acetone solution. This allows the conclusion that neither of these peptide oxygens is hydrogen bonded and that no specific 2----5 beta-turn structure exists to an appreciable extent.
Moret
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E
Institut de Chimie Organique, Université de Lausanne, Switzerland.
Gerothanassis
I P
IP
Hunston
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RN
Lauterwein
J
J
D055598:Chemical Phenomena; D002621:Chemistry; D004743:Enkephalin, Leucine; D005998:Glycine; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010103:Oxygen Isotopes; D011487:Protein Conformation
D010103:Oxygen Isotopes; D004743:Enkephalin, Leucine; D005998:Glycine