title: [Population genetics of HLA polymorphism in blood donors of Bremen and Hannover].
abstract: 501 blood donors from Bremen have been typed for HLA-ABC and -DR. The results are compared with HLA data obtained on 474 blood donors from Hannover. The gene frequencies do not differ significantly between these two population samples. Comparisons with population samples from Kiel, Hamburg, Essen, Frankfurt/M., Mainz, Mannheim, Freiburg/Br., Munich and Vienna did also not reveal any remarkable differences concerning the gene frequencies. Analysis of linkage disequilibrium of two-factor and three-factor haplotypes could show that the typical Caucasoid allele combination A1/B8 is not a constituent part of three-factor haplotype combinations. Between the population samples from Bremen and Hannover no marked differences in the distribution of two-factor and three-factor haplotype frequencies could be found.
authors.affiliation: Dept. f. Humanbiologie, Universität Bremen.
authors.forename: B
authors.initials: B
authors.lastname: Kowald
authors.forename: M
authors.initials: M
authors.lastname: Kühn
authors.forename: H
authors.initials: H
authors.lastname: Walter
authors.forename: U
authors.initials: U
authors.lastname: Diekamp
authors.forename: W
authors.initials: W
authors.lastname: Stangel
authors.forename: K
authors.initials: K
authors.lastname: Erichsen
mesh_terms: D000328:Adult; D000483:Alleles; D001782:Blood Donors; D002874:Chromosome Mapping; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000097:blood; D005828:Genetics, Population; D005860:Germany, West; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens
vernacular_title: Untersuchungen zur Populationsgenetik des HLA-Polymorphismus bei Blutspendern aus Bremen und Hannover.