title: A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.
abstract: Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.
authors.affiliation: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Obuchi
authors.forename: M
authors.initials: M
authors.lastname: Tamai
authors.forename: H
authors.initials: H
authors.lastname: Araki
authors.forename: S
authors.initials: S
authors.lastname: Omura
authors.forename: J S
authors.initials: JS
authors.lastname: Yang
authors.forename: D Q
authors.initials: DQ
authors.lastname: Yu
authors.forename: X T
authors.initials: XT
authors.lastname: Liang
authors.forename: J H
authors.initials: JH
authors.lastname: Huan
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives*; D000363:Agaricales / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: C063248:6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine; D000241:Adenosine