Hypodiploid, pseudodiploid, and normal karyotypes prevail in cytogenetic studies of medullary carcinomas of the thyroid and metastatic tissues.
Medullary carcinoma of the thyroid (MCT), often a dominantly inherited neoplasm, derived from intrathyroid C-cells of neural crest origin, is one of the solid tumors least studied cytogenetically. The cells are difficult to grow in culture, only two cell lines having ever been established. Cytogenetic studies of only 5 tumors have been reported previously. In this paper we report on the cytogenetic analyses of 8 specimens of primary and/or metastatic MCT tumor tissue from 6 patients with familial disease, including more recent metastatic tumors in lymph node and femur of a patient whose thyroid and earlier lymph node metastases were described previously. Some of these specimens were harvested sequentially over time. Hypodiploid or diploid modal numbers prevailed with normal, pseudodiploid, or hypodiploid karyotypes.
Wurster-Hill
D H
DH
Department of Pathology, Dartmouth Medical School, Hanover, N.H. 03756.
Pettengill
O S
OS
Noll
W W
WW
Gibson
S H
SH
Brinck-Johnsen
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000556:secondary; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007621:Karyotyping; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology