Halothane-inhalation system for using atracurium in rats.
This report describes an inhalation anesthetic technique employed in rats. Polyethylene-glycol 400 (PEG 400) was first designed to combine with halothane to produce a slow-releasing system of vaporized halothane. This design provided adequate anesthetic levels for treating with atracurium, a new neuromuscular blocking agent. Furthermore, isoflurane was also used in this study to examine this inhalation system for treating with atracurium. The efficient concentrations of inhalated anesthetics for adequate anesthesia when combining with PEG were 0.15% and 0.1% for halothane and isoflurane, respectively. This safe efficient state of anesthesia was maintained throughout the experimental course for treating atracurium, and might be used in clinical trials.
Yang
Y C
YC
Department of Pharmacology, Kaohsiung Medical College, Taiwan, Republic of China.
Chen
I J
IJ
Yip
W H
WH
Tseng
C K
CK
D000769:Anesthesia, Inhalation / Q000379:methods*; D000818:Animals; D001279:Atracurium / Q000494:pharmacology*; D006221:Halothane / Q000008:administration & dosage*; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains
D001279:Atracurium; D011092:Polyethylene Glycols; D007530:Isoflurane; D006221:Halothane