Pseudohypertestosteronemia during danazol therapy. A case report.
Several steroid radioimmunoassay kits, particularly testosterone, cross-react with danazol, producing false elevations of serum steroid levels. A patient taking danazol simultaneously developed signs of virilization and an apparent 15-fold elevation in her serum testosterone. Discontinuation of danazol resulted in a prompt return to physical and biochemical normality.
Miller
E J
EJ
Department of Obstetrics and Gynecology, Darnall Army Community Hospital, Fort Hood, Texas 76544-5063.
Coleman
F H
FH
D000328:Adult; D003613:Danazol / Q000009:adverse effects* / Q000378:metabolism; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011245:Pregnadienes / Q000009:adverse effects*; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood*; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014770:Virilism / Q000139:chemically induced*
D011245:Pregnadienes; D013739:Testosterone; D003613:Danazol