Antineoplastic agents, 162. Zephyranthes candida.
The Chinese medicinal plant Zephyranthes candida was found to contain a cytostatic constituent. Separation of a n-BuOH extract directed by results of a bioassay employing the P-388 lymphocytic leukemia led to trans-dihydronarciclasine [2] as the principal cytostatic agent with ED50 3.2 X 10(-3) micrograms/ml.
Pettit
G R
GR
Cancer Research Institute, Arizona State University, Tempe 85287-1604.
Cragg
G M
GM
Singh
S B
SB
Duke
J A
JA
Doubek
D L
DL
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D007941:Leukemia P388 / Q000188:drug therapy; D015394:Molecular Structure
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; C064338:dihydronarciclasine