title: Concentrations of ampicillin in human serum and mixed saliva following a single oral administration of lenampicillin, and relationship between serum and mixed saliva concentrations.
abstract: The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060 micrograms/ml, respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r = 0.71, P less than 0.001, was found.
authors.affiliation: Second Department of Oral Surgery, Nihon University School of Dentistry, Matsudo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Uda
authors.forename: H
authors.initials: H
authors.lastname: Omata
authors.forename: J
authors.initials: J
authors.lastname: Shibutani
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Komiya
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Kuboyama
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood*; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis*
chemical_list: D000667:Ampicillin; C045384:lenampicillin