Evidence that cytochalasins reduce the size of polymerization nuclei during actin polymerization.
In a double-logarithmic plot of the rate of actin polymerization against monomer concentration, the slope has a lower value in the presence of the fungal metabolites cytochalasin B and D than in their absence. This suggests that actin oligomers which serve as polymerization nuclei are smaller in the presence of cytochalasins than in their absence.
Wendel
H
H
Institut für Zoologie der Technischen Hochschule Darmstadt, Bundesrepublik Deutschland.
Dancker
P
P
D000199:Actins / Q000378:metabolism*; D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology*; D015638:Cytochalasin D / Q000494:pharmacology*; D007700:Kinetics; D046911:Macromolecular Substances; D009132:Muscles / Q000378:metabolism; D011817:Rabbits
D000199:Actins; D046911:Macromolecular Substances; D015638:Cytochalasin D; D003571:Cytochalasin B