title: Experimental studies on the oxygen tension in the myocardium and changes of cardiac function in hypoxia.
abstract: Using adult mongrel dogs, experiments were performed to elucidate the relationship between the changes in the myocardial oxygen tension (PmO2) in anoxia and disturbances of cardiac function. Dogs, forced to inspire 100% N2, suffered from a respiratory arrest after 5 min, and developed acute anoxia. However, by 100% O2 inhalation 2 min after the onset of the respiratory arrest, the anoxia rapidly resolved. The arterial oxygen tension (PaO2), left intra ventricular oxygen tension (PLVO2) and PmO2 showed the most pronounced fall 2 min after the respiratory arrest induced by N2 inhalation. The arterial carbon deoxide tension (PaCO2) decreased until the respiratory arrest, after which it started to rise. When inhalation of 100% O2 was initiated at the anoxia, the PaO2, PLVO2 and PmO2 recovered within 1 min followed by a rise beyond the baseline value. Left ventricular end-diastolic pressure (LVEDP), left atrial mean pressure (LAm), left ventricular systolic pressure (LVSP), aortic mean pressure (Aom), maximum rate of force development by left ventricle (LVmax.dp/dt), total peripheral resistance (TPR), cardiac output (CO) and heart rate (HR) were measured. At the onset of anoxia, these parameters decreased sharply. When inhalation of 100% O2 was initiated within 2 min of the respiratory arrest, these disturbances of cardiac function recovered rapidly. The fall of PmO2 plays an important role in the impairment of cardiac function.
authors.affiliation: Department of Veterinary Surgery, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Yoshino
authors.forename: E
authors.initials: E
authors.lastname: Iida
authors.forename: Y
authors.initials: Y
authors.lastname: Wakao
authors.forename: M
authors.initials: M
authors.lastname: Muto
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001011:Aorta / Q000502:physiology / Q000503:physiopathology; D001785:Blood Gas Monitoring, Transcutaneous / Q000662:veterinary*; D001794:Blood Pressure; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D009584:Nitrogen; D012131:Respiratory Insufficiency / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary; D014655:Vascular Resistance; D016276:Ventricular Function
chemical_list: D009584:Nitrogen