Immunosuppressive activity and toxicity of cyclosporine metabolites characterized by mass spectroscopy and nuclear magnetic resonance.
Copeland
K R
KR
Department of Clinical Chemistry, Health Sciences Clinical Research Centre, Winnipeg, Manitoba, Canada.
Yatscoff
R W
RW
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003524:Cyclosporins / Q000493:pharmacokinetics* / Q000633:toxicity; D004261:DNA Replication; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics* / Q000633:toxicity; D016030:Kidney Transplantation / Q000276:immunology*; D007684:Kidney Tubules / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D013552:Swine
D003524:Cyclosporins; D007166:Immunosuppressive Agents