Comparison of Gd-BOPTA with Gd-DTPA in MR imaging of rat liver.
A new lipophilic compound, gadolinium benzyloxypropionictetraacetate (BOPTA), with a high rate of biliary excretion was assessed as a magnetic resonance (MR) hepatospecific contrast-enhancing agent and compared with Gd-DTPA (diethylenetriaminepentaacetic acid) in MR imaging of normal rats. T1-weighted spin-echo images obtained before and after administration of each contrast agent at doses of 0.25, 0.5, and 1.0 mmol/kg showed greater enhancement of the liver with Gd-BOPTA than with Gd-DTPA, with the advantage more evident at lower doses. Images obtained with an inversion recovery sequence at the null value of rat liver parenchyma after injection of 0.1- and 0.5-mmol/kg doses of the contrast agent provided better evidence of the greater and longer-lasting hepatic enhancement due to Gd-BOPTA when compared with that of Gd-DTPA. Gd-BOPTA is a potentially good contrast agent for obtaining prolonged enhancement of the liver, permitting studies during the long time needed to acquire conventional T1-weighted images.
Pavone
P
P
Department of Radiology, University of L'Aquila, Ospedale S.M. Collemaggio, Italy.
Patrizio
G
G
Buoni
C
C
Tettamanti
E
E
Passariello
R
R
Musu
C
C
Tirone
P
P
Felder
E
E
D000085:Acetates / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D004369:Pentetic Acid / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA