title: 6-Methylangelicins: new monofunctional photochemotherapeutic agents for psoriasis.
abstract: The monofunctional furocoumarins, the 6-methylangelicins, were tested for their antiproliferative activity with various animal models and for genotoxicity in micro-organisms and in mammalian cells. The most active compound was 6,4,4'-trimethylangelicin, which showed a high antiproliferative effect and reduced genotoxicity in comparison with 8-methoxypsoralen (8-MOP). Some of these compounds were also tested clinically by topical application on 17 patients with psoriasis. They appeared to be more active than 8-MOP in clearing psoriasis without inducing skin phototoxicity. The methylangelicins also caused skin pigmentation.
authors.affiliation: Division of Dermatology, Hospital of Santa Chiara, Trento, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cristofolini
authors.forename: G
authors.initials: G
authors.lastname: Recchia
authors.forename: S
authors.initials: S
authors.lastname: Boi
authors.forename: F
authors.initials: F
authors.lastname: Piscioli
authors.forename: F
authors.initials: F
authors.lastname: Bordin
authors.forename: F
authors.initials: F
authors.lastname: Baccichetti
authors.forename: F
authors.initials: F
authors.lastname: Carlassare
authors.forename: M
authors.initials: M
authors.lastname: Tamaro
authors.forename: B
authors.initials: B
authors.lastname: Pani
authors.forename: N
authors.initials: N
authors.lastname: Baburdi
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D011564:Furocoumarins / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D011564:Furocoumarins; D004247:DNA; C041621:4,4',6-trimethylangelicin; D008730:Methoxsalen