title: Pharmacokinetic aspects of the sublingual administration of vincamine.
abstract: The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.
authors.affiliation: Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Aiache
authors.forename: M C
authors.initials: MC
authors.lastname: Delatte
authors.forename: P P
authors.initials: PP
authors.lastname: Leblanc
authors.forename: J P
authors.initials: JP
authors.lastname: Kantelip
authors.forename: R
authors.initials: R
authors.lastname: Gomeni
authors.forename: J L
authors.initials: JL
authors.lastname: Steimer
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D011897:Random Allocation; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*; D014749:Vincamine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014748:Vinca Alkaloids; D014749:Vincamine