title: Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes.
abstract: The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.
authors.affiliation: Genetics Group, Los Alamos National Laboratory, NM 87545.
authors.forename: J
authors.initials: J
authors.lastname: Meyne
authors.forename: R J
authors.initials: RJ
authors.lastname: Baker
authors.forename: H H
authors.initials: HH
authors.lastname: Hobart
authors.forename: T C
authors.initials: TC
authors.lastname: Hsu
authors.forename: O A
authors.initials: OA
authors.lastname: Ryder
authors.forename: O G
authors.initials: OG
authors.lastname: Ward
authors.forename: J E
authors.initials: JE
authors.lastname: Wiley
authors.forename: D H
authors.initials: DH
authors.lastname: Wurster-Hill
authors.forename: T L
authors.initials: TL
authors.lastname: Yates
authors.forename: R K
authors.initials: RK
authors.lastname: Moyzis
mesh_terms: D000663:Amphibians / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D001717:Birds / Q000235:genetics; D002871:Chromosome Banding; D002875:Chromosomes; D004247:DNA; D005399:Fishes / Q000235:genetics; D007621:Karyotyping; D008322:Mammals / Q000235:genetics; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D012104:Reptiles / Q000235:genetics; D013045:Species Specificity; D014714:Vertebrates / Q000235:genetics*
chemical_list: D004247:DNA