Long-term potentiation in intact infant rat hippocampus.
In rats 14-28 days of age, high-frequency stimulation of the perforant path granule cell synapse in the dentate gyrus produced long-term potentiation of the population spike that was comparable in magnitude (150-250% of baseline) and duration (120 min) to that produced in adult animals with the same stimulation paradigm. In contrast, potentiation of the excitatory postsynaptic potential occurred inconsistently.
Trommer
B L
BL
Division of Neurology, Evanston Hospital, IL 60201.
Routtenberg
A
A
D000200:Action Potentials; D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains