Experimental immune mediated arthritis in rhesus monkeys. A model for human rheumatoid arthritis?
The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived from Mycobacterium tuberculosis, Streptococcus pyogenes, and Eubacterium aerofaciens. The tested bacterial antigens proved to be not arthrogenic. Bovine type II collagen induced clinical arthritis in 50% of the rhesus monkeys. Type II collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histological, genetic, and immunologic features associated with human RA.
Bakker
N P
NP
TNO Primate Center, Rijswijk, The Netherlands.
van Erck
M G
MG
Zurcher
C
C
Faaber
P
P
Lemmens
A
A
Hazenberg
M
M
Bontrop
R E
RE
Jonker
M
M
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology* / Q000473:pathology; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007114:Immunization; D007271:Injections, Intradermal; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008297:Male
D000942:Antigens, Bacterial; D003094:Collagen