[Functional activity of peripheral blood leukocytes as criteria of the general toxic and sensitizing action of polyoxypropyleneamine hardeners of synthetic resins].
General toxic and sensitizing characteristics of polyoxypropylenamine (POPamine) hardeners of synthetic resins under chronic inhalation impact of their aerosols were experimentally studied. Characteristic variations of synthetic activity of blood leukocytes were studied during the process of chronic POPamine intoxication. High allergic effect of those compounds was established along with the conformity of body sensitizing indicators to variations in synthetic activity of peripheral blood cells. It was concluded that the account of sensitizing POPamine characteristics was necessary when setting up hygienic standards for the work zone air. The possibility of using the indicators of synthetic activity of blood leukocytes as an additional criterion for evaluating allergenic activity of chemical substances was also pointed out.
Shevchenko
A M
AM
Iavorovskiĭ
A P
AP
Bogorad
V S
VS
Efremova
L D
LD
Martseniuk
P P
PP
D000280:Administration, Inhalation; D000818:Animals; D005260:Female; D007962:Leukocytes / Q000502:physiology*; D010969:Plastics / Q000633:toxicity*; D011126:Polypropylenes / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D010969:Plastics; D011126:Polypropylenes; C064807:polyoxypropyleneamine
Funktsional'naia aktivnost' leĭkotsitov perifericheskoĭ krovi kak kriteriĭ obshchetoksicheskogo i sensibiliziruiushchego deĭstviia polioksipropilenaminnykh otverditeleĭ sinteticheskikh smol.