B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation.
Thymuses from female (New Zealand black x New Zealand white)F1 [( NZB x NZW]F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB x NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.
Fariñas
M C
MC
Department of Medicine, Stanford University School of Medicine, California 94305.
Adkins
B
B
Stall
A M
AM
Weissman
I
I
Strober
S
S
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology* / Q000528:radiation effects; D002465:Cell Movement; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D007150:Immunohistochemistry; D015182:Lymphatic Irradiation; D051379:Mice; D008815:Mice, Inbred Strains; D013950:Thymus Gland / Q000473:pathology* / Q000528:radiation effects