[System of ethanol and acetaldehyde metabolism in the rat liver during the development of ethanol tolerance].
Following daily intraperitoneal injections of ethanol at a dose of 3.5 g/kg rats developed tolerance to its hypnotic action, which was manifested in a drastic decrease of ethanol--induced sleep time and the number of animals sleeping more than 60 min. In the liver, this process was characterized by an elevated alcohol dehydrogenase activity and a decreased aldehyde dehydrogenase one, whereas that of MEOS remained unchanged.
Satanovskaia
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D000079:Acetaldehyde / Q000378:metabolism*; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde
Sistema obmena étanola i atsetal'degida pecheni krys pri razvitii tolerantnosti k étanolu.