Testicular toxicity following short-term exposure to tri- and hexavalent chromium: an experimental study in the rat.
The effect of tri- and hexavalent chromium after intraperitoneal administration for 5 consecutive days on testicular histopathology and epididymal sperm number was assessed. Treatment with hexavalent chromium induced testicular atrophy and a reduction in epididymal sperm number after 60 days. No effect was seen after treatment with trivalent chromium.
Ernst
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Department of Neurobiology, University of Aarhus, Denmark.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides; D002840:Chromates / Q000633:toxicity; D002857:Chromium / Q000008:administration & dosage / Q000633:toxicity*; D017608:Chromium Compounds; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D017670:Sodium Compounds; D013076:Sperm Count / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D002712:Chlorides; D002840:Chromates; D017608:Chromium Compounds; D017670:Sodium Compounds; D002857:Chromium; C028982:sodium chromate(VI); C017133:chromous chloride