title: Effect of reuse on dialyzer efficacy.
abstract: The effect of reuse on dialyzer efficacy was examined by measuring blood compartment volume and dialyzer mass transfer coefficient (maximum dialyzer clearance) as a function of dialyzer use number. The 102 polysulfone dialyzers tested (F60 and HF80, Fresenius) were reprocessed on Renatron machines using peroxyacetic acid as the dual cleansing and sterilizing agent. Each dialyzer was used an average of 14.4 +/- 5.7SD times and was tested once (twice for 13/102 dialyzers) during a routine dialysis session at an arbitrary use number (7.6 +/- 5.3; range 1 to 24). The parameters tested were found to decrease only marginally with reuse, corresponding to a blood compartment volume loss of approximately 1% (R = 0.04) over a 5-week/15-use period and a decrease in dialyzer mass transfer coefficient of approximately 3% (R = 0.07 and 0.06) over the same period for urea and creatinine, respectively. It was concluded that the loss in dialyzer efficacy is negligible over the average use period of almost 5 weeks per dialyzer.
authors.affiliation: Department of Chemical Engineering, Lakehead University, Thunder Bay, Ontario, Canada.
authors.forename: L J
authors.initials: LJ
authors.lastname: Garred
authors.forename: B
authors.initials: B
authors.lastname: Canaud
authors.forename: J L
authors.initials: JL
authors.lastname: Flavier
authors.forename: C
authors.initials: C
authors.lastname: Poux
authors.forename: C
authors.initials: C
authors.lastname: Polito-Bouloux
authors.forename: C
authors.initials: C
authors.lastname: Mion
mesh_terms: D001810:Blood Volume; D003404:Creatinine / Q000378:metabolism; D004209:Disposable Equipment; D015312:Hemodialysis Solutions / Q000032:analysis; D006801:Humans; D016014:Linear Models; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000295:instrumentation*; D014508:Urea / Q000378:metabolism
chemical_list: D015312:Hemodialysis Solutions; D008567:Membranes, Artificial; D014508:Urea; D003404:Creatinine