title: The short- and long-term effect of single high-dose intra-operative electron beam irradiation of retroperitoneal structures--an experimental study in dogs.
abstract: Intra-operative electron beam radiotherapy is a new treatment modality. The abdomen is the area of greatest potential applicability of IORT and therefore its effect on retroperitoneal structures was investigated in a canine model. The retroperitoneal structures tolerate 30 to 40 Gy well, with the exception of the radiation-sensitive ureter which showed fibrosis. Twenty to 25 Gy is within the safe dose limits for the clinical application of IORT.
authors.affiliation: Division of Surgical Oncology, Gronigen University Hospital, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: D M
authors.initials: DM
authors.lastname: Mehta
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: P
authors.initials: P
authors.lastname: Westra
authors.forename: J
authors.initials: J
authors.lastname: van den Dungen
authors.forename: R G
authors.initials: RG
authors.lastname: Dijkstra
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D004285:Dogs; D004583:Electrons; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology; D005355:Fibrosis / Q000209:etiology; D007432:Intraoperative Period; D007674:Kidney Diseases / Q000209:etiology; D008159:Lumbar Vertebrae / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D012185:Retroperitoneal Fibrosis / Q000209:etiology; D012187:Retroperitoneal Space / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery; D013125:Spinal Neoplasms / Q000209:etiology; D014513:Ureter / Q000473:pathology