title: [The effect of VUFB diltiazem tablets on the sick sinus and on electrophysiologic parameters of the heart atrium].
abstract: Using invasive electrophysiological methods, the authors evaluated the preparation Diltiazem VUFB tablets on parametres of sinus automaticity in the "sick sinus syndrome" and on properties of the atria. They confirmed significant inhibition of automaticity which is not signalized by a corresponding decrease of the nodal frequency, and may remain concealed and lead unexpectedly to disorders of the cardiac rhythm. This is not a specific property of the preparation, a similar action on the sick sinus is exerted by all calcium antagonists with clinically confirmed effects on the conduction system. Diltiazem is already produced in this country and sold on the market with the name of Discordin SPOFA tablets.
authors.affiliation: I. interní klinika lékarské fakulty UK, Plzen.
authors.forename: A
authors.initials: A
authors.lastname: Mádle
authors.forename: J
authors.initials: J
authors.lastname: Kudová
authors.forename: J
authors.initials: J
authors.lastname: Vainer
authors.forename: J
authors.initials: J
authors.lastname: Smíd
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004110:Diltiazem / Q000008:administration & dosage / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012804:Sick Sinus Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D013607:Tablets
chemical_list: D013607:Tablets; D004110:Diltiazem
vernacular_title: Ucinky diltiazemu VUFB tablety na "sick sinus" a na elektrofyziologické ukazatele srdecních síní.