Orosomucoid (ORM) typing by isoelectric focusing: evidence for several new variants including ORM1 and ORM2 silent alleles.
Human orosomucoid (ORM) is composed of two tightly linked loci, ORM1 and ORM2, located on chromosome 9q. Some haplotypes contain duplicated ORM1 or ORM2. The present study using isoelectric focusing has revealed seven ORM haplotypes including new variants and/or silent alleles detected in eight Japanese families. ORM1*5.2-ORM2*15 in combination with common ORM1*1-ORM2*1 produced a five-band pattern. ORM1*5-ORM2*1 was observed in three families. ORM2*9 was coexistent with ORM1*1 or ORM1*2.1. ORM1*Q0 was linked to ORM2*1 or ORM2*14. ORM2*Q0 was suggested to be in association with ORM1*2. The ORM haplotypes with a silent gene must have arisen from unequal crossing-over between the tandemly duplicated genes of ORM.
Yuasa
I
I
Department of Legal Medicine, Tottori University School of Medicine, Yonago, Japan.
Umetsu
K
K
Suenaga
K
K
Ikebuchi
J
J
Suzuki
T
T
D000483:Alleles; D006239:Haplotypes; D006801:Humans; D007525:Isoelectric Focusing; D009961:Orosomucoid / Q000235:genetics*; D010375:Pedigree
D009961:Orosomucoid