The need for central and peripheral tolerance in the B cell repertoire.
The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination.
Goodnow
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Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.
Adelstein
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S
Basten
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D000818:Animals; D000916:Antibody Diversity / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002470:Cell Survival; D015536:Down-Regulation; D015322:Gene Rearrangement, B-Lymphocyte; D006183:H-2 Antigens / Q000276:immunology; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic; D009113:Muramidase / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D006183:H-2 Antigens; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D009113:Muramidase