Transforming growth factor-beta 1 (TGF-beta 1) is a bifunctional immune regulator for mucosal IgA responses.
Porcine transforming growth factor-beta 1 (TGF-beta 1) exerts a unique bifunctional immunoregulatory effect on IgA responses in murine mesenteric and Peyer's patches lymphocyte cultures. TGF-beta 1 is a potent costimulator of LPS-induced IgA responses. The enhancement was observed at TGF-beta 1 at 0.1 to 10 ng/ml in both early and late phases of IgA responses from Day 5 to Day 14 in cultures. On the contrary, TGF-beta 1 exerts a profound immunosuppressive effect on IL-5-induced IgA synthesis. TGF-beta 1 is a natural cytokine produced by intestinal epithelial cells and may account for the polyclonal production and secretion of IgA at the mucosal surface and ensure the integrity of the primary host defense by mucosa-associated lymphoid tissues (MALT).
Chen
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Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106.
Li
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D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D015847:Interleukin-4 / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D015291:Transforming Growth Factors / Q000502:physiology*
D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D008070:Lipopolysaccharides; D015847:Interleukin-4; D007073:Immunoglobulin E; D015291:Transforming Growth Factors