[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs].
Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003630:Daunorubicin / Q000627:therapeutic use; D004351:Drug Resistance; D006863:Hydrogen-Ion Concentration; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains
D000970:Antineoplastic Agents; D003630:Daunorubicin
Rol' vnutrikletochnogo pH v vozniknovenii ustoĭchivosti leĭkoznykh kletok k protivoopukholevym preparatam.