title: Facilitatory action of muscarine on the slow afterdepolarization of rat dorsolateral septal nucleus neurons in vitro.
abstract: Intracellular recordings were made from an isolated rat brain slice preparation containing the dorsolateral septal nucleus (DLSN). Calcium-dependent slow afterdepolarizations (slow-ADPs) were observed in a population of neurons, which exhibited bursts of action potentials. Bath application of muscarine (10-20 microM) augmented the slow-ADP and triggered burst firing on top of the slow-ADP. This effect of muscarine was blocked by atropine (1 microM). Muscarine augmented the slowly decaying inward current (slow-ADC) recorded by voltage clamping the afterpotential of cathodally-evoked spikes. Our data suggest that some of the burst-like activity induced by muscarine in a select population of rat DLSN neurons is mediated partly by augmentation of the current which underlies the slow-ADP.
authors.affiliation: Department of Physiology, Kurume University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hasuo
authors.forename: J P
authors.initials: JP
authors.lastname: Gallagher
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects / Q000502:physiology*
chemical_list: D009116:Muscarine