title: Immunohistochemistry of superoxide dismutase-1 in developing human brain.
abstract: The developmental changes in superoxide dismutase (SOD)-1 were studied in brains ranging in age from human fetuses to adults by immunohistochemistry. SOD-positive neurons and glial cells appeared with maturation in each region, and increased progressively with gestational and postnatal age. This phenomenon implies a relationship between SOD-1 gene expression and the anti-oxidant defence mechanism in developing neurons and glia.
authors.affiliation: Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: H
authors.initials: H
authors.lastname: Kuruta
authors.forename: T
authors.initials: T
authors.lastname: Mito
authors.forename: S
authors.initials: S
authors.lastname: Houdou
authors.forename: H
authors.initials: H
authors.lastname: Konomi
authors.forename: R
authors.initials: R
authors.lastname: Yao
authors.forename: K
authors.initials: K
authors.lastname: Onodera
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D002675:Child, Preschool; D004622:Embryo, Mammalian / Q000201:enzymology*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase