Cytopathic effects of measles virus on the human intestinal mucosa.
We reported a case of measles with diarrhea in an infant. Capsule biopsy samples of intestinal mucosa taken 14 days after onset of fever was damaged and had low disaccharidase activities. Virus particles were found in the damaged villous cell. Second intestinal mucosa biopsy samples taken 28 days after onset of fever was found to be normal in structure, but lactase and sucrase activities were still low. Mucosal damage by virus particles was the cause of diarrhea in our infant.
Jirapinyo
P
P
Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Thakerngpol
K
K
Chaichanwatanakul
K
K
D001706:Biopsy; D003588:Cytopathogenic Effect, Viral; D003968:Diarrhea, Infantile / Q000209:etiology / Q000473:pathology*; D004186:Disaccharidases / Q000378:metabolism; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000201:enzymology / Q000382:microbiology / Q000473:pathology*; D007421:Intestine, Small / Q000201:enzymology / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008457:Measles / Q000473:pathology; D008459:Measles virus / Q000502:physiology* / Q000648:ultrastructure; D013393:Sucrase / Q000378:metabolism
D004186:Disaccharidases; D013393:Sucrase