title: Experimental endolymphatic hydrops: are cochlear and vestibular symptoms caused by increased endolymphatic pressure?
abstract: The correlation between inner ear pressure and cochlear function was investigated in guinea pigs with unilaterally obliterated endolymphatic sacs and ducts. In 11 animals that developed endolymphatic hydrops, auditory thresholds as monitored by auditory evoked action potentials had increased with recruitment. Most of these animals also experienced episodes of spontaneous nystagmus. In control ears endolymphatic pressure did not differ more than 0.5 cm H2O from perilymphatic pressure. In six of 11 hydropic ears, endolymphatic pressure was more than 0.5 cm H2O higher than perilympathic pressure; auditory thresholds in all these ears had deteriorated within 2 weeks before pressure recording. No further hearing deterioration within this period was noted in five hydropic ears with endolymphatic pressure equal to or lower than perilymphatic pressure. Endolympathic-perilymphatic pressure gradients may contribute to auditory threshold increase in endolymphatic hydrops, but are not its only cause.
authors.affiliation: ENT Department, University Hospital, Zürich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Böhmer
authors.forename: N
authors.initials: N
authors.lastname: Dillier
mesh_terms: D000818:Animals; D003051:Cochlea / Q000503:physiopathology; D004487:Edema / Q000473:pathology / Q000503:physiopathology*; D004710:Endolymph / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006320:Hearing Tests; D007761:Labyrinthine Fluids / Q000502:physiology*; D009760:Nystagmus, Physiologic; D011312:Pressure; D012018:Reflex / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular; D014723:Vestibular Aqueduct / Q000473:pathology; D015837:Vestibular Diseases / Q000473:pathology / Q000503:physiopathology*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000503:physiopathology