Peculiar ultraviolet absorbing moieties of human osteoarthritic cartilage.
The ultraviolet absorbing components of human cartilage have been measured by microspectrophotometry. The characteristics of the chondrocytes appeared to be identical, irrespective of the pathology. However the matrix of osteoarthritis cartilage contained components that absorbed maximally in the region of 270 to 250 nm; such components were not found in the matrix of cartilage of non-arthritic joints. Substances that absorb maximally in this region of the ultraviolet could generate free radicals.
Chayen
J
J
Division of Cellular Biology, Kennedy Institute of Rheumatology, London.
Bitensky
L
L
Nahir
A M
AM
D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000032:analysis* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology*; D013056:Spectrophotometry, Ultraviolet