[The effect of alpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period].
Inhibition of an increase in total content of unsaturated fatty acids in microsomal lipids induced by phenobarbital, alterations of parameters of the fluorescent probe 1,8-ANS-binding with membranes as well as restrictions in induction of liver microsomal monooxygenase enzymatic system were detected during postischemic period after total liver tissue ischemia. Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period. Possible factors responsible for limitations of the phenobarbital inducing effect during postischemic period are discussed.
Sharapov
V I
VI
Grek
O R
OR
Zykov
A A
AA
D000817:Anilino Naphthalenesulfonates / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D004790:Enzyme Induction; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism*; D008012:Lidocaine / Q000494:pharmacology*; D008099:Liver / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology*
D000817:Anilino Naphthalenesulfonates; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System; D008012:Lidocaine; D010634:Phenobarbital
Vliianie alpha-tokoferola i lidokaina na strukturno-funktsional'nuiu perestroĭku membran éndoplazmaticheskogo retikuluma pecheni pri induktsii fenobarbitalom v postishemicheskom periode.