[Chemotherapeutic effectiveness of a new derivative of 5-alkyl-3N-furanones in experimental staphylococcal infection].
High chemotherapeutic efficacy of the compound 1929, a new derivative of 5-alkyl-3H-furanones was shown in albino mice with experimental staphylococcal infection caused by intraperitoneal administration to the animals. The efficacy was found to be higher than that of furagin used for comparison. The average therapeutic dose (AD50) of the compound for intraperitoneal administration amounted to 40 mg/kg while the average lethal dose (LD50) was 3000 mg/kg.
Tomnikov
A Iu
AIu
Shub
G M
GM
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005663:Furans / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D051379:Mice; D013203:Staphylococcal Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D005663:Furans; C064076:compound 1929
Khimioterapevticheskaia éffektivnost' novogo proizvodnogo 5-alkil-3N-furanonov pri éksperimental'noĭ stafilokokkovoĭ infektsii.