[Serum fructosamine assay in the evaluation and follow-up of diabetics].
Fructosamine (FRA) levels were determined in diabetic and nondiabetic patients. A normal mean of 2.38 mmol/L +/- 0.21 (SD), and range of 2.0-2.8, was found in 156 nondiabetic subjects. A highly significant correlation was found between FRA and glycosylated hemoglobin, and between FRA and fasting glucose and 2-hour postprandial glucose in the 163 diabetics. The mean FRA in 60 diabetics receiving oral hypoglycemic agents was 3.05 +/- 0.34. It ranged from 3.28 +/- 0.65 in patients with NIDDM receiving insulin to 3.50 +/- 1.03 in those with IDDM. Over 60% of the latter were inadequately controlled, as assessed by FRA levels. FRA repeated during 4-12 months in 68 patients showed no improvement in 45%, despite determined attempts to control blood glucose. However, fasting blood glucose in diabetics with normal FRA was 134 +/- 51 mg/dl. Therefore, a consistently normal level of FRA does not indicate normoglycemia. The FRA assay is rapid, simple, economical and of significant aid in the control of diabetes.
Shapiro
M S
MS
Meir General Hospital, Sapir Medical Center, Kfar Saba.
Ludvinovsky
S
S
Weiss
E
E
Arber
I
I
D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D019270:Fructosamine; D006442:Glycated Hemoglobin / Q000032:analysis; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use
D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines; D007004:Hypoglycemic Agents