title: Interaction of free fatty acids with the erythrocyte membrane as affected by hyperthermia and ionizing radiation.
abstract: The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37 degrees, but also at 42 degrees and 47 degrees C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection against hypotonic hemolysis occurs, without altering the minimum concentration for 100% hemolysis.
authors.affiliation: Department of Biochemistry, K. Marcinkowski Academy of Medicine, Poznan, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Rybczynska
authors.forename: A
authors.initials: A
authors.lastname: Csordas
mesh_terms: D003652:Decanoic Acids / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism* / Q000528:radiation effects; D005227:Fatty Acids / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D007850:Lauric Acids / Q000378:metabolism; D009227:Myristic Acids / Q000378:metabolism; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D003652:Decanoic Acids; D005227:Fatty Acids; D007850:Lauric Acids; D009227:Myristic Acids; D009829:Oleic Acids; D019301:Oleic Acid; C011459:elaidic acid