Vasoconstriction in the renal vascular bed during exercise: studies in control and heart failure rabbits.
1. The effects of graded treadmill exercise on renal blood flow (RBF) were examined in seven rabbits, in which congestive heart failure (CHF) was produced by the administration of doxorubicin, 1 mg/kg, twice weekly for 8 weeks, and in seven controls. A third group of five rabbits underwent doxorubicin treatment with the addition of surgical section of the left renal sympathetic nerve. 2. During submaximal exercise, there was a small reduction in RBF in controls, which was greatly exaggerated in CHF. 3. In both control and heart failure rabbits, there was a precipitous fall in RBF as exercise fatigue developed. 4. Renal sympathectomy ablated these changes in RBF during exercise. 5. It is concluded that in heart failure there is an exaggerated, sympathetically mediated, diversion of blood flow away from the kidney. The onset of exercise fatigue in both normal and heart failure rabbits is accompanied by a marked intensification of this process.
Langton
D
D
Monash University Department of Medicine, Monash Medical Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia.
Way
D
D
Trigg
L
L
Blake
D
D
McGrath
B
B
D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000098:blood supply*; D005082:Physical Exertion / Q000502:physiology; D011817:Rabbits; D014661:Vasoconstriction
D004317:Doxorubicin