Topographical distribution of fluoride in iliac bone of a fluoride-treated osteoporotic patient.
The electron microprobe was used to display the topographical distribution pattern of fluoride (F) at the microscopical level in the iliac bone of an osteoporotic patient treated with fluoride. Composite x-ray image of F K alpha emission revealed a high concentration of fluoride in the periosteal and endosteal bone layers, in the cancellous bone, and in certain osteons, which corresponded to the bone formed during the period of fluoride treatment. Fluoride was also concentrated around the Haversian canals in the vicinity of the capillary blood vessels by a diffusion process. Morphometric analysis showed that more cancellous bone than cortical bone is formed.
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Instut de Morphologie, Centre Médical Universitaire, Geneva, Switzerland.
Baud
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D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000378:metabolism*; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D011859:Radiography; D012969:Sodium Fluoride / Q000493:pharmacokinetics* / Q000627:therapeutic use
D012969:Sodium Fluoride