Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with pulmonary sarcoidosis.
The expression of c-sis proto-oncogene in bronchoalveolar mononuclear cells was studied in seven patients with pulmonary sarcoidosis. By means of nuclear run on transcription assay, the transcriptional level of c-sis proto-oncogene in bronchoalveolar mononuclear cells was investigated. Expression of c-sis proto-oncogene in bronchoalveolar mononuclear cells was enhanced. Enhancement of c-sis transcription may be involved in the process of activation of bronchoalveolar mononuclear cells in patients with pulmonary sarcoidosis.
Deguchi
Y
Y
Third Department of Internal Medicine, Osaka University School of Medicine, Japan.
Kishimoto
S
S
D000199:Actins / Q000235:genetics; D015152:Blotting, Northern; D015153:Blotting, Western; D001992:Bronchoalveolar Lavage Fluid / Q000235:genetics / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics*; D014170:Transformation, Genetic
D000199:Actins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas