In vitro susceptibility of dermatophytes from Munich to griseofulvin, miconazole and ketoconazole.
Various recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Epidermophyton floccosum from Munich were subjected to antimicrobial susceptibility testing using the microdilution method. Both azoles miconazole and ketoconazole were found to be more active than griseofulvin. Comparatively high inhibitory concentrations of griseofulvin were especially found with Tr. mentagrophytes. On the whole miconazole turned out to be even somewhat more effective than ketoconazole. Considering the minimum inhibitory concentrations found at least some of the strains tested might not be open to eradication in clinical terms with conventional treatment protocols.
Korting
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HC
Department of Dermatology and Venereology, Ludwig-Maximilians-Universität, Munich, Germany FR.
Rosenkranz
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D003883:Arthrodermataceae / Q000187:drug effects*; D005860:Germany, West; D006118:Griseofulvin / Q000494:pharmacology*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D006118:Griseofulvin; D008825:Miconazole; D007654:Ketoconazole