title: Effects of isoflurane on spinal inhibitory potentials.
abstract: The effects of isoflurane on segmental spinal cord potentials and heterosegmental slow positive potentials in response to fore- and hindpaw stimulation were studied in the rat. The heterosegmental slow positive potential and late (second) component of the slow positive wave (P2) of segmental spinal cord potential, thought to be primary afferent depolarization, an agent of presynaptic inhibition activated by a feedback loop via supraspinal structures, were greatly suppressed by the anesthetic. In contrast the negative wave (N1) of segmental spinal cord potential, believed to be synchronized activity of dorsal horn neurons, was only minimally affected. No differential effects of isoflurane on spinal cord potentials activated by fore- and hindpaws were found. Thus, the inhibitory activities of the spinal cord, particularly those produced by a feedback loop via supraspinal structures, are suggested to be highly vulnerable to isoflurane.
authors.affiliation: Department of Anesthesiology, Niigata University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimoji
authors.forename: N
authors.initials: N
authors.lastname: Fujiwara
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: S
authors.initials: S
authors.lastname: Denda
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
chemical_list: D007530:Isoflurane