Hypothesis: ischaemic plaque necrosis as the initiator of unstable angina/acute myocardial infarction?
1. Coronary atherosclerotic plaque complications are important in precipitating acute coronary events such as unstable angina and myocardial infarction. 2. The hypothesis is put forward that plaque complications are initiated by increases in local coronary artery tone sufficient to cut off the vasa vasorum blood supply to the plaque and result in its ischaemic necrosis.
Boyd
G W
GW
Department of Medicine, University of Tasmania, Hobart, Australia.
D000787:Angina Pectoris / Q000209:etiology*; D000789:Angina, Unstable / Q000209:etiology*; D003324:Coronary Artery Disease / Q000150:complications* / Q000473:pathology; D003327:Coronary Disease / Q000150:complications*; D003328:Coronary Thrombosis / Q000150:complications* / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology*; D009336:Necrosis