title: Effectiveness of BCG vaccination against tuberculous meningitis: a case-control study in São Paulo, Brazil.
abstract: A case-control study was carried out in the Metropolitan Region of São Paulo, Brazil, to determine the protection against tuberculous meningitis conferred by BCG vaccination to children aged less than 5 years. The BCG vaccination coverage in the study area was about 88%. A total of 72 tuberculous meningitis patients were studied as well as 505 neighbourhood and 81 hospital controls. Analysis of the data using a conditional logistic regression for matched case-control studies indicated that the efficacy of BCG was similar for both groups of controls, that for neighbourhood controls (84.5%) being slightly greater than that for hospital controls (80.2%). No significant interactions were found between vaccination status and sex, age, or socioeconomic status.
authors.affiliation: Department of Epidemiology, Faculdade de Saúde Publica, Universidade de São Paulo, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Wünsch Filho
authors.forename: E A
authors.initials: EA
authors.lastname: de Castilho
authors.forename: L C
authors.initials: LC
authors.lastname: Rodrigues
authors.forename: S R
authors.initials: SR
authors.lastname: Huttly
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014390:Tuberculosis, Meningeal / Q000453:epidemiology / Q000517:prevention & control*; D014505:Urban Population
chemical_list: D001500:BCG Vaccine