Vascular capacitance in rats subjected to chemical renal medullectomy.
Selective renal medullary destruction is produced in rats by a single injection of 2-bromoethylamine hydrobromide. The object of these studies was to investigate whether destruction of the renal medulla in normal rats would alter vascular capacitance. Conscious bromoethylamine-treated rats (n = 15) were compared with control saline-injected rats (n = 12). Mean circulatory filling pressure was measured during a brief circulatory arrest caused by inflation of a right atrial balloon. Blood volume was determined from plasma volume (iodine-125-labeled albumin) and hematocrit. Mean circulatory filling pressure was measured at resting blood volume and after rapid blood volume changes. Vascular compliance was derived from the mean circulatory filling pressure-blood volume curve. The bromoethylamine-treated rats were significantly hypertensive compared with control rats (mean arterial pressure 133 +/- 2 and 114 +/- 3 mm Hg, respectively, p less than 0.001) and had a significant tachycardia (475 +/- 8 and 443 +/- 10 beats/min, respectively, p = 0.02). Blood volume, plasma volume, hematocrit, and sodium excretion were no different. There was no significant difference in mean circulatory filling pressure (6.5 +/- 0.2 and 6.8 +/- 0.2 mm Hg, respectively, p = 0.4) or vascular compliance (3.64 +/- 0.20 and 3.53 +/- 0.12 ml/kg/mm Hg, respectively, p = 0.7). The position of the vascular pressure-volume curve was unchanged indicating no change in vascular capacity. This would suggest that the destruction of renal medullary vasodepressor mechanisms does not result in alterations in vascular capacitance.
Edmunds
M E
ME
Department of Medicine, University of Leicester, UK.
Russell
G I
GI
Burton
P R
PR
Swales
J D
JD
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D005021:Ethylamines; D005260:Female; D006439:Hemodynamics; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012079:Renal Circulation / Q000502:physiology; D014563:Urodynamics; D014655:Vascular Resistance
D005021:Ethylamines; C004504:2-bromoethylamine