[Evoked acoustic oto-emissions: effects of atropine].
The Evoked Otoacoustic Emissions (EOE) are a sinusoidal wave complex coming from the contractile properties of the cochlea and particularly of the outer hair cells. This activity is influenced by the centrifugal pathways whose transmitter is acetylcholine. In order to study the effects of the functional block of the cochlea, ten young normal subjects were examined recording the EOE before and ten mins after the i.v. infusion of 1 mg of atropine. The statistical analysis of the results has shown a significant decrease only in EOE appearance threshold in absence of modifications of the saturation level. These data have led us to believe that atropine blocking of the centrifugal pathways causes a disfunction of the outer hair cells that accept less energy to be transduced into a neural stimulus and on the other hand more energy as EOEs.
Salonna
I
I
Istituto Policattedra Otorinolaringoiatria-Cattedra Audiologia, Università di Bari.
Bartoli
R
R
Longo
G
G
D000293:Adolescent; D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001309:Auditory Threshold; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male
D001285:Atropine
Otoemissioni acustiche evocate: effectti dell'atropina.