Blood brain barrier function in vascular dementia.
To investigate blood-brain barrier (BBB) function measured as an albumin ratio (cerebrospinal fluid/serum) in vascular dementia (VD) samples from 53 patients and 30 healthy controls were analysed. The VD group showed a higher mean albumin ratio than controls (8.5 +/- 3.8 and 5.7 +/- 2.1, respectively). The albumin ratio did not correlate significantly with age, nor with individual clinical vascular factors. The results of the present study suggest that the altered BBB might be a consequence of small vessel disorder rather than evidence of infarcts.
Wallin
A
A
Department of Psychiatry and Neurochemistry, Gothenburg University, Sweden.
Blennow
K
K
Fredman
P
P
Gottfries
C G
CG
Karlsson
I
I
Svennerholm
L
L
D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier; D015140:Dementia, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D012709:Serum Albumin / Q000493:pharmacokinetics*
D012709:Serum Albumin