title: [Acute fatal pulmonary embolism: its prevention, diagnosis and treatment].
abstract: Acute fatal pulmonary embolism is one cause of sudden death which should be guarded against. It is the most often missed diagnosis in sudden death cases within the hospital. Clinical pictures of 10 patients with acute fatal pulmonary embolism proved by autopsy were examined to elucidate the problems of diagnosis, and to look for an effective treatment, and a method of prevention. Common risk factors were old age and immobility due to stroke or postoperative state. Common past histories were hypertension, diabetes mellitus, obesity, atrial fibrillation and hyperlipidemia. Electrocardiogram and echocardiogram showed that in these patients there was definite evidence of acute right ventricular overload. High doses of intravenous urokinase should be given whenever acute cardiovascular collapse develops in such high risk patients. Emergent pulmonary angiogram and pulmonary embolectomy could be life-saving in patients with acute massive pulmonary embolism. Prevention is, however, the best treatment. In addition to anticoagulation medication, frequent change of body position and early mobilization are important precautions to prevent fatal pulmonary embolism developing in such patients.
authors.affiliation: Division of Cardiology, National Cardiovascular Center.
authors.forename: S
authors.initials: S
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: N
authors.initials: N
authors.lastname: Nakanishi
authors.forename: T
authors.initials: T
authors.lastname: Kunieda
authors.forename: C
authors.initials: C
authors.lastname: Yutani
authors.forename: A
authors.initials: A
authors.lastname: Shimouchi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D003645:Death, Sudden; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
chemical_list: D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator