Acute oral toxicity of sodium fluoride and monofluorophosphate separately or in combination in rats.
Fasted Sprague-Dawley male rats were used in three experiments to determine the acute LD50 values of fluoride when it was administered intragastrically as NaF, disodium monofluorophosphate (Na2PO3F, MFP) or NaF and MFP. Another study was done to examine the relationship between the likelihood of a fatal outcome and peak plasma fluoride concentrations as well as 6-hour AUC values. It was concluded that fatalities due to the acute toxic effects of fluoride were: (1) independent of the chemical form in which it was given; (2) independent of the vehicle (dentifrice or water), and (3) not predictable in terms of a well-defined threshold range of peak plasma fluoride concentrations or AUC values.
Whitford
G M
GM
Department of Oral Biology, Medical College of Georgia, Augusta.
Birdsong-Whitford
N L
NL
Finidori
C
C
D000284:Administration, Oral; D000818:Animals; D003802:Dentifrices; D004338:Drug Combinations; D005459:Fluorides / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D010710:Phosphates / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000633:toxicity*; D013270:Stomach
D003802:Dentifrices; D004338:Drug Combinations; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides