Effect of quinidine on platelets.
The effects of quinidine on platelets over a wide range of concentrations of the drug were studied. It was found that quinidine at high concentrations (1 and 1.5 mM) induced platelets to undergo profound ultrastructural changes and 14C-serotonin release. In addition, the drug at these concentrations caused marked inhibition of platelet aggregation mediated by adenosine diphosphate, adrenaline, collagen and arachidonate but had no effect on ristocetin-induced agglutination. However, quinidine at 10 microM (a pharmacological concentration) had only a variable inhibitory effect on adrenaline-induced platelet aggregation.
Chong
B H
BH
Department of Haematology, St. George Hospital, Kogarah, Australia.
Kaplin
I J
IJ
D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D002250:Carbon Radioisotopes; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011802:Quinidine / Q000008:administration & dosage / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood
D002250:Carbon Radioisotopes; D010975:Platelet Aggregation Inhibitors; D012701:Serotonin; D007770:L-Lactate Dehydrogenase; D011802:Quinidine