title: [Changes in the levels of erythrocyte membrane proteins in hypertension].
abstract: The distribution of specific proteins in erythrocyte membranes was studied in patients with essential hypertension (EH) (n = 44), secondary hypertension of renal genesis (n = 42), and healthy persons (n = 44). Densitograms of gel analyzed after electrophoresis of erythrocyte ghosts showed a twofold increase in polypeptide levels in EH patients as compared to those in health persons: the band being 4.5 (Mw = 52-59 kD) and 6 (Mw = 35 kD), respectively. Radioimmunoassay has demonstrated that the amount of monoclonal antibodies bound to fragmented erythrocyte membranes from EH patients is greater by at least 28% than that in healthy persons. Patients with secondary arterial hypertension of renal genesis showed no significant difference in monoclonal antibody binding as compared to the controls.
authors.forename: V A
authors.initials: VA
authors.lastname: Loginov
authors.forename: S A
authors.initials: SA
authors.lastname: Sukhoplechev
authors.forename: B I
authors.initials: BI
authors.lastname: Minchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Aleksandrov
authors.forename: R G
authors.initials: RG
authors.lastname: Oganov
mesh_terms: D000328:Adult; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood*; D015151:Immunoblotting / Q000379:methods; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000150:complications
chemical_list: D008565:Membrane Proteins
vernacular_title: Izmenenie kolichestvennogo sootnosheniia membrannykh belkov éritrotsitov pri gipertonicheskoĭ bolezni.