title: Relationship between fatty acid synthesis, transport and total lipid content during human fetal lung development.
abstract: Levels of fatty acid binding proteins (FABPs), lipids as well as activities of fatty acid synthesizing enzymes such as fatty acid synthase and ATP-citrate lyase increase with gestation showing maximum at term in human fetal lung. However, the activity of ATP-citrate lyase showed the same trend up to 30 weeks of gestation before declining slightly at term. These results indicate the importance of supply and/or synthesis of fatty acids when lung surfactant synthesis begins; thereby showing a correlation between the FABPs, lipid pattern and the activities of fatty acid synthesizing enzymes during prenatal lung development.
authors.affiliation: Department of Biochemistry, University of Calcutta, College of Science.
authors.forename: G
authors.initials: G
authors.lastname: Sa
authors.forename: T
authors.initials: T
authors.lastname: Das
authors.forename: M
authors.initials: M
authors.lastname: Mukherjea
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D064429:Fatty Acid Synthases / Q000378:metabolism; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000201:enzymology* / Q000378:metabolism; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D064429:Fatty Acid Synthases; D001275:ATP Citrate (pro-S)-Lyase