Pancreatic and biliary secretion in the anesthetized Syrian golden hamster in response to secretin, cholecystokinin-octapeptide, bombesin, and carbachol.
The aim of this study was to characterize pancreatic and biliary secretion in the anesthetized Syrian golden hamster. There were spontaneous secretions of both pancreatic juice and bile, which were increased by 400% and 60% by optimal doses of secretin with parallel increases in bicarbonate concentrations to 150 and 80 mM, respectively. CCK-8 and bombesin had little or no effect on pancreatic water and electrolyte secretion, whereas carbachol increased flow rate and bicarbonate concentration. CCK-8, bombesin, and carbachol all increased pancreatic protein secretion but had no effect on biliary secretion. In conclusion, the patterns of pancreatic and biliary secretion in the hamster are different from those in other rodents but are quite similar to those in humans.
Ali
A E
AE
Department of Physiological Sciences, University of Manchester, U.K.
Rutishauser
S C
SC
Case
R M
RM
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D001839:Bombesin / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D002712:Chlorides / Q000378:metabolism; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D010189:Pancreatic Juice / Q000378:metabolism*; D010424:Pentobarbital; D011188:Potassium / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D012844:Sincalide / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D001639:Bicarbonates; D002712:Chlorides; D012633:Secretin; D002217:Carbachol; D012964:Sodium; D010424:Pentobarbital; D012844:Sincalide; D001839:Bombesin; D011188:Potassium