Influence of acetaminophen on antipyrine kinetics in rats.
Studies have suggested that acetaminophen may inhibit the liver metabolism of several drugs. Due to the expected clinical relevance of these findings, the present study was undertaken to examine acetaminophen effects on in vivo drug metabolism in the rat, using the model substrate antipyrine. Oral doses of 15 mg/kg acetaminophen were administered twice daily for 7 days. Antipyrine kinetics were determined before and immediately after acetaminophen treatment in rats (used as their own control). Acetaminophen treatment significantly increased antipyrine half-life by 29% and reduced its clearance by 24%, without affecting its volume of distribution. Further studies are warranted to determine the relevance and mechanism of these findings.
Vial
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Department of Pharmacology, INSERM U-80/CNRS UA-1177/UCBL, Alexis Carrel Faculty of Medecine, Lyon, France.
Sauveur
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Descotes
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D000082:Acetaminophen / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D051381:Rats; D011919:Rats, Inbred Strains
D000082:Acetaminophen; D000983:Antipyrine