The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy.
In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.
Bach
Flemming W
FW
Department of Neurology, Gentofte Hospital, CopenhagenDenmark Department of Neurology, Rigshospitalet, CopenhagenDenmark Department of Clinical Physiology, Bispebjerg Hospital, CopenhagenDenmark Department of Clinical Neurophysiology, Gentofte Hospital, CopenhagenDenmark Department of Neurology, Hvidøre Hospital, CopenhagenDenmark.
Jensen
Troels S
TS
Kastrup
Jens
J
Stigsby
Bent
B
Dejgård
Anders
A
D000328:Adult; D003929:Diabetic Neuropathies / Q000150:complications*; D004311:Double-Blind Method; D006181:H-Reflex / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012023:Reflex, Monosynaptic / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects
D008012:Lidocaine