title: Phenotypic differences in upper genital tract abnormalities and reproductive history in dizygotic twins exposed to diethylstilbestrol in utero. A case report.
abstract: Major phenotypic variations in reproductive function and upper genital tract abnormalities were found between 30-year-old dizygotic twins exposed in utero to diethylstilbestrol (DES). The women were exposed to maternal DES doses of 12.5-50.0 mg daily starting from the 12th gestational week as documented in the original antepartum obstetric office records. Twin A had primary involuntary infertility of over four years' duration associated with a severe DES uterine deformity on hysterosalpingography (HSG). A complete evaluation demonstrated all other infertility investigations to be normal. Twin B had two term pregnancies but a significant history of reproductive loss, including three miscarriages and one ectopic pregnancy. HSG demonstrated mild DES-induced changes. Cervical adenosis was observed only in the more severely affected twin.
authors.affiliation: Department of Obstetrics and Gynecology, Ottawa Civic Hospital, University of Ottawa, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Claman
authors.forename: M J
authors.initials: MJ
authors.lastname: Berger
mesh_terms: D000014:Abnormalities, Drug-Induced; D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D010641:Phenotype; D011247:Pregnancy; D011271:Pregnancy, Ectopic; D011297:Prenatal Exposure Delayed Effects; D014429:Twins, Dizygotic; D014599:Uterus / Q000002:abnormalities*
chemical_list: D004054:Diethylstilbestrol