Granule cells in the ventral dentate gyrus are essential for kainic acid-induced wet dog shakes but not those induced by precipitated abstinence in morphine-dependent rats.
Wet dog shaking elicited by systemic administration of kainic acid is eliminated by bilateral destruction of ventral dentate granule cells. In contrast, wet dog shaking induced by naltrexone precipitated abstinence in morphine-dependent rats is unaffected by destruction of ventral dentate granule cells. It is concluded that at least two anatomically distinct brain regions modulate wet dog shaking behavior.
Mitchell
C L
CL
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Grimes
L M
LM
Hong
J S
JS
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D009020:Morphine; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013239:Stereotyped Behavior / Q000187:drug effects*; D019966:Substance-Related Disorders / Q000378:metabolism*
D009270:Naloxone; D009020:Morphine; D007608:Kainic Acid