Effects of propylene glycol-containing diets on acetaminophen-induced methemoglobinemia in cats.
Soft-moist cat foods contain 7 to 13% propylene glycol (PG) on a dry-weight basis. These diets induce Heinz body formation in feline RBC. In this study, we evaluated cats on a control diet and on a commercial diet containing 8.3% PG. All cats on the PG diet developed an increase in the number of circulating Heinz bodies. We then administered acetaminophen to cats on each diet to determine whether RBC from cats on PG diets were more susceptible to oxidant stress. Methemoglobin concentrations were significantly greater in cats in PG diets after acetaminophen administration. These data indicate that RBC from cats fed PG diets are more susceptible to oxidative stress.
Weiss
D J
DJ
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
McClay
C B
CB
Christopher
M M
MM
Murphy
M
M
Perman
V
V
D000082:Acetaminophen / Q000009:adverse effects*; D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D002371:Cat Diseases / Q000097:blood* / Q000139:chemically induced; D002415:Cats; D004906:Erythrocyte Count / Q000662:veterinary; D004912:Erythrocytes / Q000032:analysis; D006366:Heinz Bodies; D008706:Methemoglobin / Q000032:analysis; D008708:Methemoglobinemia / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D010084:Oxidation-Reduction; D011409:Propylene Glycols / Q000009:adverse effects*; D012156:Reticulocytes
D011409:Propylene Glycols; D000082:Acetaminophen; D008706:Methemoglobin