Behavior of genetic markers in recipients after bone marrow transplantation and problems in forensic medicine.
The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.
Ikemoto
S
S
Department of Legal Medicine and Human Genetics, Jichi Medical School, Tochigi, Japan.
Kajii
E
E
Tsuchida
S
S
Amemiya
Y
Y
Kato
K
K
Miura
Y
Y
D001789:Blood Group Antigens / Q000235:genetics; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000032:analysis; D005554:Forensic Medicine; D005819:Genetic Markers / Q000032:analysis*; D006801:Humans; D010641:Phenotype; D012463:Saliva / Q000032:analysis; D014170:Transformation, Genetic
D001789:Blood Group Antigens; D005819:Genetic Markers