Efficacy and safety of combinations of nitrendipine, atenolol, and hydrochlorothiazide in black hypertensive patients.
Twenty-four black hypertensive patients were studied in a randomized, double-blind trial of combinations of nitrendipine, atenolol, and hydrochlorothiazide. After six weeks, blood pressure was normalized in all three treatment groups, i.e. diastolic blood pressure less than 95 mmHg and a decline in diastolic blood pressure of at least 5 mmHg from baseline. The drug combinations containing hydrochlorothiazide were associated with higher incidence of metabolic abnormalities, especially hypokalaemia and hyperuricaemia.
Zaeh
D
D
University of Medicine and Dentistry, New Jersey Medical School, Newark 07103.
Haider
B
B
Brown
P
P
Silas
E
E
D001262:Atenolol / Q000008:administration & dosage* / Q000009:adverse effects; D044383:Black People; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage* / Q000009:adverse effects
D006852:Hydrochlorothiazide; D001262:Atenolol; D009568:Nitrendipine