Who gets a second primary cancer after gastric cancer surgery?
Eleven patients presented with a second primary cancer during follow-up after surgery for gastric carcinoma. In these patients the serum concentrations of C1-INH and IgG prior to gastric cancer surgery were similar to those of 53 patients with recurrence of gastric cancer. In these two groups, the preoperative C1-INH concentrations were higher and IgG lower (P less than 0.001 and P less than 0.05) when compared to 36 patients alive and disease-free 5 years after surgery. The median time between surgery and signs of recurrence was 11 months, whereas the median time until signs of the second primary cancer was 4 years. A patient with gastric carcinoma who pre-operatively has high C1-INH and low IgG is liable either to have recurrence or to develop a second primary cancer. Our data indicate that these variables represent a cancer susceptibility feature appropriate to the host.
Janssen
C W
CW
Department of Surgery, University of Bergen, Norway.
Lie
R T
RT
Maartmann-Moe
H
H
Matre
R
R
D000368:Aged; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery*
D003174:Complement C1 Inactivator Proteins; D007074:Immunoglobulin G