title: HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx.
abstract: We studied class II antigen expression and tumor-infiltrating leukocytes (TIL) in tissue sections of 69 squamous cell carcinomas of the larynx and 24 lymph node metastases in the neck. HLA-DR expression was found only in eight well-differentiated, highly keratinizing squamous cell carcinomas comprising seven of the verrucous variety and one ventriculosaccular tumor. None of the metastases was positive for DR antigen. Neither primary tumors nor autologous metastases stained for DP or DQ antigens. DR-positive tumors shared a peculiar pattern of TIL composed mainly of T cells, most of which belonged to the cytotoxic/suppressor subset, and B cells. These neoplasms had in common a slow rate of growth, and are considered low-grade carcinomas in the literature. We conclude from our study that HLA-DR expression seems to characterize tumors with a prominent infiltrate and an excellent prognosis.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Virgen de las Nieves, Universidad de Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Esteban
authors.forename: F
authors.initials: F
authors.lastname: Ruiz-Cabello
authors.forename: A
authors.initials: A
authors.lastname: Concha
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Ayala
authors.forename: J A
authors.initials: JA
authors.lastname: Sánchez-Rozas
authors.forename: F
authors.initials: F
authors.lastname: Garrido
mesh_terms: D002291:Carcinoma, Papillary / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007820:Laryngeal Mucosa / Q000276:immunology; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011379:Prognosis
chemical_list: D006684:HLA-DR Antigens