Involvement of inhibitory innervation in reflex tracheal dilatation induced by lung inflation.
We investigated the involvement of inhibitory innervation in reflex tracheal dilatation (RTD) induced by inflating the lungs in dogs. RTD was inhibited about 50% by 100 micrograms propranolol injected into the cranial thyroid artery, but was unaffected by adrenalectomy. Residual RTD under beta-blockade was abolished by sections of both the bilateral superior laryngeal nerves and spinal cord at the C1 level. These findings suggest that RTD may be mediated by adrenergic innervation and partly by nonadrenergic inhibitory innervation.
Misawa
M
M
Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Takahashi
Y
Y
Hosokawa
T
T
Yanaura
S
S
D000315:Adrenalectomy; D000818:Animals; D004285:Dogs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008168:Lung / Q000502:physiology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012018:Reflex / Q000502:physiology; D012119:Respiration; D013564:Sympathetic Nervous System / Q000502:physiology*; D014132:Trachea / Q000294:innervation / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology
D006584:Hexamethonium Compounds; D011433:Propranolol; D010646:Phentolamine