title: Pathogenesis of skin and liver neoplasms in white suckers from industrially polluted areas in Lake Ontario.
abstract: Increased prevalences of epidermal and hepatobiliary neoplasms in white suckers (Catostomu commersoni) and brown bullheads (Ictalurus nebulosus) in the Western region of Lake Ontario have been associated with industrial pollution, but the identity and causative role of environmental carcinogens have not yet been established. Most epidermal tumors of lip and body skin are benign focal proliferations that occur in fish from the polluted Hamilton region, and also in fish from less polluted sites in the Great Lakes. These skin tumors in white suckers do not have consistent alterations in cellular glutathione S-transferases (GST), suggesting that growth of skin tumors is not promoted by chemicals normally detoxified by GST. However, elevated levels of glutathione peroxidase (GPO) and glutathione reductase (GR) in skin papillomas are indicative of promotional peroxidative tissue injury, either caused directly by xenobiotics or indirectly by chemical-induced inflammation. Liver tumors in white suckers from Lake Ontario include preneoplastic, benign, and malignant populations of hepatocellular and biliary cells, all of which are more prevalent in fish from polluted sites. These liver tumors are consistently associated with chronic cholangiohepatitis and segmental cholangiofibrosis, but these conditions also occur in white suckers in non-industrial locations. Thus, the natural occurrence of biliary disease, not attributable to industrial pollution, may have some influence on the development of liver tumors. Some preneoplastic lesions and the majority of neoplastic hepatocellular and biliary lesions in white suckers have low levels of total GST, indicating that these liver neoplasms are not promoted by xenobiotics normally detoxified by hepatic GSTs.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pathology, University of Guelph, Ontario, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Hayes
authors.forename: I R
authors.initials: IR
authors.lastname: Smith
authors.forename: T H
authors.initials: TH
authors.lastname: Rushmore
authors.forename: T L
authors.initials: TL
authors.lastname: Crane
authors.forename: C
authors.initials: C
authors.lastname: Thorn
authors.forename: T E
authors.initials: TE
authors.lastname: Kocal
authors.forename: H W
authors.initials: HW
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D003531:Cypriniformes; D005393:Fish Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D005618:Fresh Water; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007221:Industry; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D009864:Ontario; D010212:Papilloma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D012867:Skin / Q000201:enzymology / Q000473:pathology; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D014876:Water Pollution
chemical_list: D015415:Biomarkers; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase