Functional cerebral imaging by susceptibility-contrast NMR.
In vivo measurement of cerebral physiology by dynamic contrast-enhanced NMR is demonstrated. Time-resolved images of the cerebral transit of paramagnetic contrast agent were acquired using a new ultrafast NMR imaging technique and a novel mechanism of image contrast based on microscopic changes in tissue magnetic susceptibility. Global hypercapnia in dogs was used to establish the relationship between susceptibility-induced signal change and brain blood volume, and the response of gray and white matter to this microvascular stimulus was measured.
Belliveau
J W
JW
Department of Radiology, Massachusetts General Hospital, Boston.
Rosen
B R
BR
Kantor
H L
HL
Rzedzian
R R
RR
Kennedy
D N
DN
McKinstry
R C
RC
Vevea
J M
JM
Cohen
M S
MS
Pykett
I L
IL
Brady
T J
TJ
D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000378:metabolism; D004285:Dogs; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D003287:Contrast Media