Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug.
A patient with moderate pancytopenia thought to be due to chloroquine ingestion was shown to have granulocyte progenitors (CFU-G) which were abnormally sensitive in vitro to chloroquine. As he required further anti-malarial prophylaxis, his marrow was prospectively tested in vitro with proguanil and its metabolite cycloguanil. The patient's CFU-G were also abnormally sensitive to these agents and predicted neutropenia was verified when the patient had a trial course of proguanil. We believe this is the first instance of in vivo confirmation of in vitro CFU-G drug sensitivities.
Humphrey
C A
CA
Haematology Laboratory, Craigavon Area Hospital, Northern, Ireland.
French
A
A
Morris
T C
TC
D000380:Agranulocytosis / Q000175:diagnosis*; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002738:Chloroquine / Q000009:adverse effects*; D003114:Colony-Forming Units Assay; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000175:diagnosis*; D002727:Proguanil / Q000009:adverse effects; D011446:Prospective Studies
D002738:Chloroquine; D002727:Proguanil