Localization and hormonal regulation of ovarian production of histamine in the sheep.
Concentrations of histamine were measured within the follicular wall, follicular fluid and ovarian interstitium throughout the periovulatory period in sheep. Histamine within follicular tissue declined after the onset of the preovulatory surge of luteinizing hormone (LH) and remained low until after ovulation, when levels then increased markedly. Alterations in histamine within the follicular wall were not reflected by corresponding changes within follicular fluid or ovarian interstitium. Release of histamine from tissue during short-term incubation was greatest for follicles obtained after ovulation, which was not influenced by presence of LH in the incubation medium. Luteinizing hormone caused depletion of stores of histamine from the wall of follicles collected before the preovulatory surge of LH. Histamine could act as a paracrine mediator in the follicular mechanisms of ovulation and(or) luteinization.
Murdoch
W J
WJ
Department of Animal Science, University of Wyoming, Laramie 82071.
D000818:Animals; D005260:Female; D015571:Follicular Fluid / Q000032:analysis; D006632:Histamine / Q000096:biosynthesis*; D007986:Luteinizing Hormone / Q000502:physiology*; D006080:Ovarian Follicle / Q000378:metabolism; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation / Q000502:physiology*; D012756:Sheep
D006632:Histamine; D007986:Luteinizing Hormone