Two simple translocations in a primary squamous cell carcinoma of the head and neck.
A 59-year-old white man was diagnosed with primary squamous cell carcinoma at the base of the tongue (clinical stage T4N3aM0). Cytogenetic analysis of the metaphase spreads obtained from primary cultures of the tumor tissue revealed a clonal abnormality with a 46,XY,t(2;6) (p23;q21),t(18;19)(q21;q13) karyotype.
Tharapel
S A
SA
Department of Pediatrics, University of Tennessee, Memphis.
Lester
E P
EP
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic