[The efficacy of antioxidant therapy in patients with tuberculosis of the lungs and the correction of lipid peroxidation processes].
The article deals with the efficacy of the antioxidative therapy in tuberculosis. Besides chemotherapeutic drugs, the administration of alpha-tocopherol, vitamin C and sodium nucleinate brings about higher rates of smear-negative cases and shorter period of cavity closure. In case of tuberculosis, lipid peroxidation (LPO) stimulation accompanied by a sharp drop of superoxide dismutase (SOD) enzyme activity is observed. This process is considered to be a manifestation of the decompensation taking place in the antiradical cell defense systems. In the course of treatment, the LPO level seems to decrease, while SOD activity and SOD/LPO ratio tend to rise. The comparison of the results obtained in every group indicated that a combined administration of alpha-tocopherol, vitamin C and sodium nucleinate proved to be the most effective.
Safarian
M D
MD
Karagezian
K G
KG
Karapetian
E T
ET
Avanesian
N A
NA
D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology
D000975:Antioxidants
Effektivnost' antioksidantnoĭ terapii bol'nykh tuberkuleznom legkikh i korrektsiia protsessov perekisnogo okisleniia lipidov.