[Detection of antibodies to citric acid extract of skeletal muscle (CAE-ab) in the sera of patients with myasthenia gravis using indirect hemagglutination].
In this paper are described the method and results for the demonstration of the antibodies to citric acid extract of skeletal muscle (CAE-ab) in the sera from myasthenia gravis (MG) patients with or without thymoma, in patients with other diseases and in healthy controls by an indirect hemagglutination assay (IHA), were described. The CAE-ab titers were positive in 15 (71.43%) of the 21 MG patients with thymoma, the antibody titers ranging from 1:16 to 1:512. In the 35 MG patients without thymoma, as well as in the 32 healthy controls and 22 patients with other diseases, the antibody titers were all negative A statistically significant difference was found between the CAE-ab titers in the group of MG patients with thymoma and those in the other three groups. It was considered that IHA for the purpose of demonstrating CAE-ab could serve as a supplementary diagnostic method for early detection of thymoma in MG patients at an early stage.
Ma
W
W
Changhai hospital, Shanghai.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002951:Citrates / Q000276:immunology; D019343:Citric Acid; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000276:immunology*; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology*; D013945:Thymoma / Q000150:complications / Q000276:immunology*; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology*
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D002951:Citrates; D019343:Citric Acid