title: Analysis of spontaneous alcohol drinking in rhesus monkeys.
abstract: This analysis aims at determining to what extent spontaneous alcohol drinking in adult male rhesus monkeys (Macaca mulatta) represents ethanol-directed behaviour. It is shown that in a condition of free access to an ethanol/water solution (2 percent v/v) and drinking water, alcohol drinking was initiated in all subjects (n = 4) within a few days, without any specific induction procedure. Relationship between drinking behaviour and ethanol concentrations was studied in 8 subjects by use of a concurrent 3-bottle-design. 2 bottles containing ethanol solution (concentrations 2.4; 4.8; 8.16; 16.32 percent v/v), 1 bottle contained drinking water. When ethanol concentrations in the solutions increased, consumption of ethanol solutions decreased, of drinking water increased, and of total water decreased. Net ethanol intake from a certain solution was influenced by its concentration and the concentration of the concurrently available solution. After an initial increase, total net ethanol intake remained relatively constant. Consumed amounts of ethanol (on the average 2-6 ml.kg-1 per day) could lead to notable blood ethanol levels. Drinking from ethanol solution was not just an alternative for ingesting water. The observed alcohol drinking is interpreted as resulting from a central reinforcement of ethanol intake and avoidance of negative, potentially harmful effects of ethanol.
authors.affiliation: TNO Primate Center, HV Rijswijk, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Kornet
authors.forename: C
authors.initials: C
authors.lastname: Goosen
authors.forename: L G
authors.initials: LG
authors.lastname: Ribbens
authors.forename: J M
authors.initials: JM
authors.lastname: van Ree
mesh_terms: D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics; D008253:Macaca mulatta; D008297:Male; D009042:Motivation
chemical_list: D000431:Ethanol