Kidney biopsies in control or cyclosporin A-treated psoriatic patients. International Kidney Biopsy Registry of Cyclosporin A (Sandimmun) in Autoimmune Diseases.
Kidney biopsies were obtained from 14 adult patients treated with cyclosporin A (CyA) for psoriasis. These biopsies were compared with those from 16 psoriatic patients of the same age, but who were not receiving treatment with CyA. Patients receiving CyA had a maximum mean dose of 5.1 mg/kg/day for a mean duration of 15 months (range 3-37 months). Minimal or slight interstitial fibrosis, tubular atrophy or arteriolopathy were seen in the biopsies of patients receiving CyA as well as in those of the controls. No relevant CyA-related structural alterations of the kidney were detected.
D000328:Adult; D001284:Atrophy / Q000473:pathology; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000139:chemically induced; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*
D003524:Cyclosporins; D003404:Creatinine