Effects of caffeine, L-phenylisopropyladenosine and their combination on local cerebral blood flow in the rat.
The quantitative [14C]iodoantipyrine autoradiographic method was applied to study the effects of acute administration of caffeine and L-phenylisopropyladenosine (LPIA) separately or in combination on local cerebral blood flow in the rat. After the injection of caffeine, cerebral blood flow rates were decreased in 13 out of the 61 structures studied, mainly in motor and auditory areas. The administration of LPIA induced a general decrease in local cerebral blood flow, which was significant in only 4 regions. The combined administration of caffeine and LPIA induced decreases in blood flow rates in 17 brain areas, motor, limbic and hypothalamic structures and increases in 3 limbic regions. The results confirm previous data on the effect of caffeine on cerebral circulation. The consequences of LPIA administration on blood flow may originate partly from peripheral effects and may also be the reflection of the reduction in the energy demand of the brain. Finally, LPIA also seems to be able to modulate caffeine effects on local cerebral blood flow when injected simultaneously with caffeine.
Nehlig
A
A
INSERM U. 272, Nancy, France.
Pereira de Vasconcelos
A
A
Dumont
I
I
Boyet
S
S
D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010660:Phenylisopropyladenosine; D002110:Caffeine; D000241:Adenosine; D000983:Antipyrine; C008135:iodoantipyrine