Pattern of renal amyloidosis in western India. A study of 104 cases.
A total of 31,266 autopsies and 1556 renal biopsies were scrutinised over a period of 19 years (1968-1986) retrospectively and prospectively, with an aim to study the incidence and pattern of renal amyloidosis in western India. A total of 104 cases with amyloidosis were detected, 41 from the autopsy series (0.1%) and 63 from biopsies (4%). Secondary amyloidosis was seen in 83.7% and primary amyloidosis in 11.5%. The interval between the onset of predisposing disease and first evidence of amyloidosis varied from 2 months to 31 years. Tuberculosis of various organs was the main cause of secondary amyloidosis (72.4%). Nephrotic syndrome was a common mode of presentation (71.4%). Besides kidneys, which were involved in all cases, the liver, spleen and adrenals were other commonly involved organs at autopsy. Renal failure was the leading cause of death (34.1%).
Mehta
H J
HJ
Department of Nephrology and Pathology, Seth GS Medical College, Parel, Bombay.
Talwalkar
N C
NC
Merchant
M R
MR
Mittal
B V
BV
Suratkal
L H
LH
Almeida
A F
AF
Acharya
V N
VN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies; D012189:Retrospective Studies; D014398:Tuberculosis, Renal / Q000150:complications