Effectiveness of certain drugs in acute malathion intoxication in rats.
The protective effects of atropine, diacetylmonoxime (DAM), and diazepam separately and in combination were investigated in rats exposed to malathion. Malathion (500 mg/kg, ip) inhibited acetylcholinesterase (AchE) activity in RBC and brain and produced hyperglycemia and hyperlactacidemia with depletion of glycogen in liver, triceps, and brain of animals 2 hr after its administration. Atropine (20 mg/kg, ip) given immediately after malathion abolished hyperglycemia and glycogenolytic effect but exhibited no effect on the recovery of inhibited AchE activity. DAM (100 mg/kg ip) given immediately after malathion significantly reactivated the inhibited AchE activity both in RBC and brain. It also partially modified hyperglycemia and glycogenolytic effect. Diazepam (50 mg/kg, ip) slightly modified AchE and abolished hyperglycemia, hyperlactacidemia, and glycogenolytic effects. A combination of these drugs protected the animals from the acute toxic effects of malathion.
Husain
K
K
Industrial Toxicology Research Centre, Lucknow, India.
Ansari
R A
RA
D000140:Acidosis, Lactic / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001285:Atropine / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology; D002074:Butanones / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000506:poisoning; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D003931:Diacetyl / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000201:enzymology; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy; D008112:Liver Glycogen / Q000378:metabolism; D008294:Malathion / Q000037:antagonists & inhibitors / Q000506:poisoning*; D008297:Male; D051381:Rats
D002074:Butanones; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D008112:Liver Glycogen; C004717:diacetylmonoxime; D001285:Atropine; D006003:Glycogen; D003931:Diacetyl; D003975:Diazepam; D008294:Malathion