An improved cation exchange HPLC method for the measurement of serum creatinine.
An improved HPLC method for the measurement of serum creatinine is described. Separation is effected using a strong cation exchange column at pH 4.7. Analytical recovery, precision and linearity are satisfactory, and the method correlates well with a kinetic Jaffé procedure. The method provides a means of accurately measuring creatinine and may be of use in the investigation of interference in creatinine assays.
Guy
J M
JM
Department of Clinical Chemistry, East Birmingham Hospital, Bordesley Green East, UK.
Legg
E F
EF
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002852:Chromatography, Ion Exchange / Q000379:methods; D003404:Creatinine / Q000097:blood*; D006801:Humans; D015203:Reproducibility of Results
D003404:Creatinine