The pupil response to E-10-hydroxynortriptyline in rabbits with ocular sympathetic paresis.
E-10-hydroxynortriptyline, a metabolite of nortriptyline with half the norepinephrine re-uptake blocking potency of the parent drug, but only 5% of its anticholinergic effect, was as effective as cocaine in demonstrating ocular sympathetic paresis. In five rabbits with unilateral superior cervical ganglionectomies, bilateral 5% cocaine HCl or E-10-hydroxynortriptyline maleate eye drops increased (P less than 0.001) the mean +/- SE anisocoria at 1 h by 1.84 +/- 0.03 mm or 2.16 +/- 0.33 mm, respectively. A single drop of E-10-hydroxynortriptyline did not alter corneal thickness or endothelial cell count.
Mindel
J S
JS
Mount Sinai School of Medicine, Department of Ophthalmology, New York, NY 10029.
Rubin
M A
MA
Kharlamb
A B
AB
D000818:Animals; D015875:Anisocoria / Q000139:chemically induced / Q000503:physiopathology; D003042:Cocaine / Q000494:pharmacology / Q000506:poisoning; D004728:Endothelium, Corneal / Q000187:drug effects / Q000473:pathology; D005123:Eye / Q000294:innervation; D019793:Fluorescein; D005452:Fluoresceins; D005456:Fluorescent Dyes; D015171:Ganglionectomy; D009661:Nortriptyline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000506:poisoning; D009994:Osmolar Concentration; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits
D005452:Fluoresceins; D005456:Fluorescent Dyes; C013567:10-hydroxynortriptyline; D009661:Nortriptyline; D003042:Cocaine; D019793:Fluorescein