Antiulcer action of Sophora flavescens root and an active constituent. I.
The effect of a methanol extract of Sophora flavescens root was examined on gastric ulcers induced in rats by HCl/ethanol in order to substantiate its reputed protective properties. Oral doses of 1 g/kg completely suppressed ulceration. Results suggest that oral administration of 50 mg/kg of vexibinol, a flavanol found in the extract, inhibited ulceration more effectively than spizofurone at 100 mg/kg.
Yamahara
J
J
Kyoto Pharmaceutical University, Kyoto, Japan.
Mochizuki
M
M
Fujimura
H
H
Takaishi
Y
Y
Yoshida
M
M
Tomimatsu
T
T
Tamai
Y
Y
D000818:Animals; D000897:Anti-Ulcer Agents; D001572:Benzofurans / Q000494:pharmacology; D000431:Ethanol; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology; D008297:Male; D000432:Methanol; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D001572:Benzofurans; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; D000431:Ethanol; C045902:spizofurone; C064849:vexibinol; D000432:Methanol