title: Modulating fluorouracil with different drugs: the Padua experience.
abstract: Several clinical experiences from Padua, Italy confirm that 5-fluorouracil may be usefully modulated by the addition of leucovorin, and especially by platinum and alpha interferon. The intra-arterial and intraperitoneal administration of such synergistic combinations has also proved to be of benefit in special subsets of patients. Perspectives of further studies are examined.
authors.affiliation: Divisione di Oncologia Medica, Ospedale Civile di Padova, Italy.
authors.forename: M V
authors.initials: MV
authors.lastname: Fiorentino
authors.forename: A
authors.initials: A
authors.lastname: Fornasiero
authors.forename: O
authors.initials: O
authors.lastname: Daniele
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy; D004357:Drug Synergism; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007370:Interferon Type I / Q000008:administration & dosage; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage
chemical_list: D007370:Interferon Type I; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate