title: LWS cone effects on rod threshold and saturation in achromats with residual cone function.
abstract: Rod saturation on flashed and steady red backgrounds was investigated in normals and three achromats, two of whom were found to have some residual cone function. LWS cones selectively reduce the background level at which rod saturation occurs and elevate rod thresholds at flashed background levels well below saturation. Both of these LWS cone actions are also present in eyes with greatly reduced LWS cone function. In normal eyes LWS cones also elevate rod thresholds on steady backgrounds. We thus conclude that LWS cones influence rods through different mechanisms under transient (flashed) and steady-state background stimulation and that the increase in rod visual sensitivity observed during prolonged presentation of a background is due to a time-dependent reduction of LWS cone influence on rods. Finally, the finding that rod-cone interactions of the same magnitude found in normals can be seen in individuals where the cones' ability to mediate vision is severely reduced suggests the rod saturation paradigm as a sensitive technique for revealing residual LWS cone function.
authors.affiliation: School of Optometry, University of California, Berkeley 94720.
authors.forename: M E
authors.initials: ME
authors.lastname: Schneck
authors.forename: A J
authors.initials: AJ
authors.lastname: Adams
authors.forename: V J
authors.initials: VJ
authors.lastname: Volbrecht
authors.forename: G
authors.initials: G
authors.lastname: Haegerstrom-Portnoy
mesh_terms: D000221:Adaptation, Ocular / Q000502:physiology; D003117:Color Vision Defects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D010786:Photoreceptor Cells / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000502:physiology; D013053:Spectrophotometry