Effectiveness of tiazofurin (NSC 286193) in treating disseminated tumor cells and micrometastases in mice.
The authors studied the metastasis-inhibiting effect of various dosages of tiazofurin in mice inoculated with a low (LLT) and a highly (LLT-HH) metastatic variant of the Lewis lung carcinoma. The tumor cells were inoculated intravenously (lung colony assay), intramuscularly (muscle-lung metastasis model), and intrasplenically (spleen-liver metastasis model), respectively. In the lung colony assay the tiazofurin proved to be curative. In the muscle-lung and the spleen-liver model the tiazofurin treatment, started after the removal of the parent tumor, drastically decreased the number of metastases in both model systems and brought about a significant prolongation of the survival time in the spleen-liver model. Authors suggest that tiazofurin as one of the most promising candidates for metastasis prevention and inhibition in human beings, too.
Lapis
K
K
I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Pápay
J
J
Paku
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D012254:Ribavirin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012263:Ribonucleosides; D012254:Ribavirin; C033706:tiazofurin