Cow's milk protein sensitivity during infancy in patients with inflammatory bowel disease.
Seventy-eight patients with inflammatory bowel disease (35 with Crohn's disease and 43 with ulcerative colitis) and a control population of 36 children without organic disease were surveyed to determine the frequency of symptoms compatible with cow's milk-protein sensitivity during infancy. The incidence of a history compatible with cow's milk sensitivity was 8.5% (3/35) in patients with Crohn's disease and 2.8% (1/36) in controls. Patients with ulcerative colitis had a significantly greater prevalence of symptoms, compared with the other patient groups (20.9%, 9/43; p less than 0.03). In addition, patients with a history of cow's milk allergy, who subsequently developed ulcerative colitis, did so at an earlier age (6.68 +/- 2.05 yr vs. 10.62 +/- 0.74 yr: p less than 0.02) than those without a history of cow's milk sensitivity. Thus, there appears to be a potential relationship between early cow's milk sensitivity and the development of ulcerative colitis.
Glassman
M S
MS
Division of Pediatric Gastroenterology, New York Medical College, Valhalla.
Newman
L J
LJ
Berezin
S
S
Gryboski
J D
JD
D000293:Adolescent; D000367:Age Factors; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications; D003424:Crohn Disease / Q000150:complications; D005512:Food Hypersensitivity / Q000150:complications*; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008894:Milk Proteins / Q000009:adverse effects*; D011795:Surveys and Questionnaires
D008894:Milk Proteins