Strobilurins F, G and H, three new antifungal metabolites from Bolinea lutea. I. Fermentation, isolation and biological activity.
Three new strobilurins F, G and H, antibiotics with antifungal activity, were isolated from cultures of Bolinea lutea Sacc. These new compounds differ from previously described analogs in their aromatic substitution. An HPLC method allows complete separation of all the components.
Fredenhagen
A
A
Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
Kuhn
A
A
Peter
H H
HH
Cuomo
V
V
Giuliano
U
U
D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D008689:Methacrylates; D015394:Molecular Structure; D000073739:Strobilurins; D013098:Xylariales / Q000378:metabolism*
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; C065215:strobilurin F; C065217:strobilurin G; C065218:strobilurin H