title: The influence of ethanol on the stem cell toxicity of benzene in mice.
abstract: BDF1 mice were exposed to 100, 300, and 900 ppm benzene vapor, and the numbers of hematopoietic progenitor cells, early and late erythroid progenitors (BFU-E and CFU-E) and granuloid progenitors (CFU-C), were determined with and without additional exposure to ethanol (5, 10, 15 vol%) in the drinking water. The duration of benzene inhalation was up to 4 weeks, 6 hr per day, 5 days per week. It was shown that the number of CFU-E per femur was depressed in a dose-dependent manner by benzene alone and also by ethanol combined with a given benzene concentration. CFU-E showed rapid regeneration after the end of the exposure, but not BFU-E and CFU-C. Prolongation of the ethanol exposure after withdrawal of benzene had only a marginal effect on progenitor cell regeneration.
authors.affiliation: Institute for Occupational and Social Medicine, University of Ulm, Federal Republic of Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Seidel
authors.forename: R
authors.initials: R
authors.lastname: Bader
authors.forename: L
authors.initials: L
authors.lastname: Weber
authors.forename: E
authors.initials: E
authors.lastname: Barthel
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice
chemical_list: D000431:Ethanol; D001554:Benzene