Toxicity and tissue residue depletion of levamisole hydrochloride in young goats.
Toxicity and tissue residue depletion studies were conducted in young goats, using an oral drench formulation of levamisole hydrochloride. In the target animal toxicity study, 3 groups of 5 goats each were given levamisole orally to provide approximately 11.88, 23.76, or 35.64 mg of levamisole HCl/kg/d for 3 consecutive days; a fourth group of 5 goats served as untreated controls. Blood samples were taken for analysis of levamisole 1 day prior to dosing and 1, 2, 3, 4, and 7 days following the third dose. At the 35.64-mg/kg dose, 2 of 5 goats responded with typical cholinergic signs of toxicosis on each of the 3 days of dosing. The times for the onset of clinical signs of toxicosis ranged from 18 to 63 minutes, with an average duration of 32 minutes. Administration of 23.76 mg of levamisole HCl/kg resulted in hyperactive behavior in 1 of 5 goats only on the first day of dosing; no abnormal behavior was observed in any of the 5 goats following the second or third dose of levamisole HCl at 23.76 mg/kg. Untoward effects were not seen in the 5 goats dosed at 11.88 mg of levamisole HCl/kg or in the controls during the 3-day dosing period or in the following 7-day observation period. Overall, the observed signs of toxicosis did not become more severe, affect more goats, or persist for a longer period on subsequent dosing days.(ABSTRACT TRUNCATED AT 250 WORDS)
Babish
J G
JG
Department of Pharmacology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Coles
G C
GC
Tritschler
J P
JP
Gutenmann
W H
WH
Lisk
D J
DJ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D007668:Kidney / Q000032:analysis / Q000378:metabolism; D007978:Levamisole / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000032:analysis / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D009132:Muscles / Q000032:analysis / Q000378:metabolism; D010865:Pilot Projects; D013997:Time Factors
D007978:Levamisole