title: Value of adenosine deaminase estimation in the diagnosis of tuberculous ascites.
abstract: Adenosine deaminase was estimated in ascitic fluids of 49 patients with ascites (19 tuberculous, 20 cirrhotic, and 10 malignant). The adenosine deaminase concentration in tuberculous ascitic fluid was 98.8 +/- 20.1 U/L (mean +/- SD), which was significantly more than that noted in cirrhotic (14 +/- 10.6 U/L) or malignant (14.6 +/- 6.7 U/L) ascitic fluids (p less than 0.001 for each). At a cut-off value of greater than 33 U/L, the sensitivity, specificity, positive and negative predictive value, and the overall diagnostic accuracy for diagnosing tuberculous ascites were 100%, 96.6%, 95%, 100%, and 98%, respectively. We conclude that estimation of adenosine deaminase in ascitic fluid is an easy and reliable method for diagnosing tuberculous ascites.
authors.affiliation: Department of Gastroenterology, M.L.N. Medical College, Uttar Pradesh, India.
authors.forename: M
authors.initials: M
authors.lastname: Dwivedi
authors.forename: S P
authors.initials: SP
authors.lastname: Misra
authors.forename: V
authors.initials: V
authors.lastname: Misra
authors.forename: R
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001201:Ascites / Q000175:diagnosis* / Q000209:etiology; D001202:Ascitic Fluid / Q000201:enzymology*; D002648:Child; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D009700:Nucleoside Deaminases / Q000032:analysis*; D011237:Predictive Value of Tests; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis
chemical_list: D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase