The role of liver and kidneys in the removal of circulating hyaluronan. An experimental study in the rat.
The concentration of circulating hyaluronan was determined in rats after either the liver or the kidneys had been excluded from the systemic circulation. Both conditions caused an increase of the serum levels of hyaluronan. However, the rate of increase was more rapid in the animals with ligated hepatic vessels compared to those with ligated renal vessels. This in vivo investigation indicates that in the rat both kidney and liver systems are important for the removal of hyaluronan from the blood.
Engström-Laurent
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Department of Medical and Physiological Chemistry, University of Uppsala, Sweden.
Hellström
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S
D000818:Animals; D006820:Hyaluronic Acid / Q000097:blood* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000502:physiology
D006820:Hyaluronic Acid