Inhibition of experimental autoimmune uveoretinitis by mercuric chloride injections in (Lewis x Brown Norway) F1 hybrid rats.
Experimental autoimmune uveoretinitis (EAU), induced in (LEW X BN) F1 rats by immunization with S antigen (S-Ag) is T cell and antibody (ab) mediated and anti-S-Ag IgE ab have been involved in the occurrence of ocular lesions. (LEW X BN) F1 rats repeatedly injected with HgCl2 develop an autoimmune disease characterized by numerous auto-ab and a high increase of serum IgE level. We hypothesize that large amounts of non anti-S-Ag IgE induced by HgCl2 would compete with anti-S-Ag induced by S-Ag immunization so as to prevent EAU to occur. Indeed (LEW X BN) F1 rats immunized with S-Ag 7 days after the first HgCl2 injection are strongly protected against EAU. The putative role of the different mercury-induced autoimmune phenomena in the protection against EAU are discussed.
Saoudi
A
A
Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
Bellon
B
B
de Kozak
Y
Y
Vial
M C
MC
Thillaye
B
B
Druet
P
P
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D019393:Arrestin; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control*; D005136:Eye Proteins / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D008627:Mercuric Chloride / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000276:immunology / Q000517:prevention & control*; D013601:T-Lymphocytes / Q000276:immunology; D014605:Uveitis / Q000276:immunology / Q000517:prevention & control*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D007073:Immunoglobulin E; D008627:Mercuric Chloride