title: Pulmonary ventilation and perfusion abnormalities and ventilation perfusion imbalance in children with pulmonary atresia or extreme tetralogy of Fallot.
abstract: Xenon-133 lung ventilation and perfusion scans were done preoperatively after cardiac catheterization and cineangiocardiography in 19 children; 6 had pulmonary atresia with an intact ventricular septum and hypoplastic right ventricle, 4 pulmonary atresia with associated complex univentricular heart, and 9 extreme Tetralogy of Fallot. The four patients with discrepancies in the sizes of the left and right pulmonary arteries on angiography had marked asymmetry of pulmonary perfusion and ventilation-perfusion imbalance on scintigraphy. Similar degrees of asymmetry and imbalance were present in 6 of the 15 children with equal-size pulmonary vessels. Asymmetry of pulmonary perfusion and ventilation-perfusion imbalance were associated with a poor prognosis.
authors.affiliation: Department of Paediatrics and Child Health, University of Cape Town, South Africa.
authors.forename: S C
authors.initials: SC
authors.lastname: Dowdle
authors.forename: D G
authors.initials: DG
authors.lastname: Human
authors.forename: M D
authors.initials: MD
authors.lastname: Mann
mesh_terms: D002648:Child; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging*; D011379:Prognosis; D011651:Pulmonary Artery / Q000002:abnormalities*; D011877:Radionuclide Imaging; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D014692:Ventilation-Perfusion Ratio; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes