title: 13-week inhalation toxicity study and fertility assessment in rats exposed to atmospheres containing adiponitrile.
abstract: Adiponitrile is an aliphatic dinitrile that is used as an intermediate in the synthesis of hexamethylenediamine. In order to asses potential health effects associated with industrial exposure, rats were exposed 6 h/d, 5 d/wk for 4 or 13 wk to atmospheres containing a range of adiponitrile concentrations and observed for signs of toxicity. A fertility assessment was also included as a component of the 13-wk study. Mortality and reduced weight gain were observed within 1 wk only in rats exposed to 493 mg/m3. Evidence of slight anemia was present in rats exposed to 99 mg/m3 and above. There was no histopathological evidence of organ toxicity in about 30 tissues from both sexes exposed up to 99 mg/m3, the highest concentration tested, for 13 wk. In addition, fertility, as monitored by reproductive performance and litter parameters, was normal in both males and females similarly exposed.
authors.affiliation: Department of Medicine and Health Sciences, Monsanto Company, St. Louis, MO 63167.
authors.forename: R D
authors.initials: RD
authors.lastname: Short
authors.forename: W V
authors.initials: WV
authors.lastname: Roloff
authors.forename: L D
authors.initials: LD
authors.lastname: Kier
authors.forename: W E
authors.initials: WE
authors.lastname: Ribelin
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D009026:Mortality; D009570:Nitriles / Q000494:pharmacology / Q000633:toxicity*; D009994:Osmolar Concentration; D051381:Rats; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects
chemical_list: D009570:Nitriles; C036546:adiponitrile