Manganese transport across the blood-brain barrier: relationship to iron homeostasis.
The binding characteristics of manganese (Mn) to transferrin (Tf) were examined on G-75 Sephadex gel columns. When 54MnCl2 was combined with Tf and immediately fractionated on the Sephadex column, 49% of 54Mn was found to Tf. The fraction of 54Mn which was Tf-bound was dependent upon the incubation period, and increased in a time-dependent fashion. In vivo, 6 hr of intravenous administration of ferric-hydroxide dextran complex significantly inhibited (p less than 0.05) 54Mn brain uptake as compared to its uptake in iron-free dextran-treated rats. These results suggest that iron (Fe) homeostasis may play an important role in the regulation of Mn transport across the blood-brain barrier (BBB).
Aschner
M
M
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Aschner
J L
JL
D000818:Animals; D001812:Blood-Brain Barrier; D005260:Female; D006706:Homeostasis; D007501:Iron / Q000378:metabolism*; D008345:Manganese / Q000493:pharmacokinetics*; D051381:Rats
D008345:Manganese; D007501:Iron