Spurious azotemia associated with 5-fluorocytosine therapy.
A patient with false elevation of serum creatinine level due to 5-fluorocytosine (5-FC) is reported. 5-FC interferes with the enzymatic method used for creatinine determination in the Kodak Ektachem analyzer. Clinicians should be aware of the potential for spurious azotemia in patients receiving 5-FC therapy for fungal urinary tract infections.
Colagiovanni
S M
SM
Department of Urology, New England Medical Center, Boston, Massachusetts.
Meares
E M
EM
Sant
G R
GR
D000619:Aminohydrolases / Q000378:metabolism; D001322:Autoanalysis; D002177:Candidiasis; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D005189:False Positive Reactions; D005260:Female; D005437:Flucytosine / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014511:Uremia / Q000139:chemically induced* / Q000175:diagnosis; D014552:Urinary Tract Infections / Q000188:drug therapy
D003404:Creatinine; D005437:Flucytosine; D000619:Aminohydrolases; C023157:creatinine deiminase