[Treatment of chronic glomerulonephritis with small doses of acetylsalicylic acid].
The purpose of the investigation was to evaluate the long-term administration of 100 mg acetylsalicylic acid in patients with chronic proliferative glomerulonephritis. Two 12-month periods are compared in the same patients (n = 19) without and with treatment. Glomerular filtration and quantitative proteinuria did not change significantly one year prior to treatment. During treatment glomerular filtration increased from 1.22 +/- 0.37 to 1.70 + 0.55 ml/s (p less than 0.01) and proteinuria declined from 2.6 + 1.1 to 1.6 +/- 1.0 g/24 h (p less than 0.01). Treatment did not influence the excretion of the metabolite prostacyclin 186 +/- 56 and 189 + 75 ng/24 h resp., and significantly reduced the thromboxane excretion from 565 +/- 267 to 348 + 123 ng/24 h, p less than 0.01). The authors assume that long-term treatment could influence in a favourable way the course of chronic proliferative glomerulonephritis.
Petrů
I
I
II. interní katedra I. lékarské fakulty, Univerzity Karlovy, Praha.
Knotková
V
V
Nĕmecek
K
K
Jáchymová
M
M
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged
D001241:Aspirin
Lécba chronické glomerulonefritidy malými dávkami acetylosalicylové kyseliny.