Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016).
Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide (1) to 19-deformyl-4'-deoxydesmycosin (3) was performed by using a mycinamicin-producing Micromonospora species. Compound 1 at low concentrations was completely converted to compound 3, however, the conversion to compound 3 was suppressed at high concentrations and 19-deformyl-4'-deoxy-2", 3'-di-O-demethyl-desmycosin (2), an intermediate leading to compound 3 accumulated.
Fujiwara
T
T
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
Takenaka
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S
D001711:Biotransformation; D008847:Micromonospora / Q000378:metabolism*; D015645:Tylosin / Q000031:analogs & derivatives* / Q000378:metabolism
C060112:TMC 016; C065226:19-deformyl-5-O-desosaminyl tylonide; D015645:Tylosin