title: A 91-day feeding study in rats with heated olestra/vegetable oil blends.
abstract: A 91-day feeding study in rats was conducted to assess the potential toxicity of heated olestra/vegetable oil blends. Olestra is a mixture of the hexa-, hepta- and octa- long-chain fatty acid esters of sucrose. The blends tested were 35/65 olestra/vegetable oil (w/w), pan-fried at 380 degrees F for 30 min to simulate home-use conditions and 75/25 olestra/vegetable oil, deep-fried at 365 degrees F for 84 hr to simulate extended food-service use. Vegetable oil, prepared using both heating conditions, unheated vegetable oil and unheated olestra/vegetable oil blends served as controls. The olestra/vegetable oil blends and vegetable-oil control were generally fed at 10% (w/w) of the diet. Two further groups received the heated olestra/vegetable oil blends at 5% of the diet. Survival, clinical signs, body weight, feed consumption, feed conversion efficiency, organ weights, organ-to-body-weight ratios, haematological parameters and histomorphology were evaluated. No adverse effects from the ingestion of heated olestra/vegetable oil blends were detected. These findings indicate that heated olestra was non-toxic and, in this respect, no different from unheated olestra or heated or unheated vegetable oil.
authors.affiliation: Procter & Gamble Company, Winton Hill Technical Center, Cincinnati, OH 45224-1703.
authors.forename: K W
authors.initials: KW
authors.lastname: Miller
authors.forename: P H
authors.initials: PH
authors.lastname: Long
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003296:Cooking; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D002149:Energy Intake / Q000187:drug effects; D005227:Fatty Acids / Q000008:administration & dosage* / Q000633:toxicity; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D010938:Plant Oils; D013395:Sucrose; C013692:sucrose polyester