title: The immune response to short-term nutritional intervention in advanced chronic obstructive pulmonary disease.
abstract: Nine patients with advanced chronic obstructive pulmonary disease (COPD) and recent weight loss resulting in a state of mild malnutrition were entered into a refeeding program at a clinical research center. They were divided into two groups, one using a hospital diet and the other a hospital diet with supplementation. Both groups of patients gained significant weight. Refeeding and weight gain were associated with a significant increase in absolute lymphocyte count and with an increase in reactivity to skin test antigens after 21 days of refeeding. Few changes occurred in large numbers of additional serum measurements during the study period. These preliminary observations suggest that dietary and supplementary refeeding may improve the immune responses in patients with COPD.
authors.affiliation: Department of Medicine, Webb Waring Lung Institute.
authors.forename: C E
authors.initials: CE
authors.lastname: Fuenzalida
authors.forename: T L
authors.initials: TL
authors.lastname: Petty
authors.forename: M L
authors.initials: ML
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Jarrett
authors.forename: R J
authors.initials: RJ
authors.lastname: Harbeck
authors.forename: R W
authors.initials: RW
authors.lastname: Terry
authors.forename: K M
authors.initials: KM
authors.lastname: Hambidge
mesh_terms: D000368:Aged; D002149:Energy Intake; D005526:Food, Formulated; D006801:Humans; D007958:Leukocyte Count; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000178:diet therapy / Q000276:immunology*; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000178:diet therapy* / Q000209:etiology; D009752:Nutritional Status; D012882:Skin Tests; D015430:Weight Gain