DNA index--parameter for the prediction of prognosis and primary radioresistance?
It was shown in the present study that irradiation of a multiclonal tumor may destroy near-diploid cell clones preferentially, while the stemline with high DNA content continues to grow after temporary arrest. This experimental observation confirms recent clinical studies.
Wagner
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Clinic and Policlinic for Radiotherapy-Radiooncology, University of Münster, Federal Republic of Germany.
D000293:Adolescent; D000782:Aneuploidy; D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000032:analysis / Q000528:radiation effects*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D012516:Osteosarcoma / Q000235:genetics; D011379:Prognosis; D013997:Time Factors
D004273:DNA, Neoplasm