title: Are gender differences in schizophrenia reflected in brain event-related potentials?
abstract: Numerous studies have reported relationships between gender and cerebral event-related potentials (ERPs) recorded from the human scalp. Recent studies have suggested that the influences of gender on ERPs may differ in persons with schizophrenia compared to healthy controls. In a further evaluation of the influences of this critical subject variable on ERP characteristics in schizophrenia, ERPs of age- and gender-matched groups (n = 72 each) of unmedicated schizophrenic patients and healthy controls were compared. ERPs elicited by left and right median nerve stimulation, checkerboard pattern visual flash, and auditory clicks were recorded from 15 scalp leads. The results confirm previous findings showing that: (1) number of comparable gender effects present in the ERP records of these two large study groups and (2) specific Diagnosis x Gender interactions suggesting that schizophrenic illness may modify normal gender influences on ERP characteristics. These data illustrate the point that matching schizophrenic patients and healthy control populations for gender is essential but not sufficient. Even in carefully matched groups, gender confounding can persist as a source of error variance because the influence can vary for different diagnostic groups.
authors.affiliation: Medical College of Pennsylvania/EPPI, Philadelphia 19129.
authors.forename: R C
authors.initials: RC
authors.lastname: Josiassen
authors.forename: R A
authors.initials: RA
authors.lastname: Roemer
authors.forename: M M
authors.initials: MM
authors.lastname: Johnson
authors.forename: C
authors.initials: C
authors.lastname: Shagass
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012727:Sex Characteristics; D012815:Signal Processing, Computer-Assisted