Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin.
Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a relation between the pathogenesis of PD and the function of cytochrome P450 subsystems.
Ferrari
M D
MD
Department of Neurology, University Hospital of Leiden, The Netherlands.
Peeters
E A
EA
Haan
J
J
Roos
R A
RA
Vermey
P
P
de Wolff
F A
FA
Buruma
O J
OJ
D000368:Aged; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism*
D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System