title: Diadenosine tetraphosphate (Ap4A) levels in HL-60 cells during differentiation into granulocytes and monocytes.
abstract: 1. Diadenosine tetraphosphate (Ap4A) levels were determined in HL-60 cells differentiating into granulocytes or monocytes after treatment for 0-7 days with retinoic acid (RA) or 4-beta-phorbol-12-myristate-13-acetate (PMA) respectively. 2. The levels increased significantly compared to untreated control cells within 2 days and then declined again. 3. In RA treated cells the levels finally decreased far below those of untreated HL-60 cells and became equal to those found in human granulocytes. 4. PMA treatment had no effect on Ap4A levels in human granulocytes. 5. A possible interaction between Ap4A and ADP-ribosyl transferase is discussed.
authors.affiliation: Department of Zoophysiology, University of Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: S M
authors.initials: SM
authors.lastname: Oredsson
authors.forename: H
authors.initials: H
authors.lastname: Olsson
authors.forename: H
authors.initials: H
authors.lastname: Bergstrand
mesh_terms: D002454:Cell Differentiation; D015226:Dinucleoside Phosphates / Q000378:metabolism*; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism* / Q000473:pathology; D009000:Monocytes / Q000166:cytology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D015226:Dinucleoside Phosphates; C020733:diadenosine tetraphosphate; D014212:Tretinoin; D013755:Tetradecanoylphorbol Acetate