A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging.
Technetium-99m-DMG-2MP (Chloro[bis[2,3-butanedionedioxime(1-)-0][2,3- butanedionedioximato (2-)-N,N',N'',N''',N'''',N'''''] (2-methylpropyl borato (2-))technetium]), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of [99mTc]DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained less than 3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of [99mTc]DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of [99mTc]DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man.
Narra
R K
RK
Squibb Institute for Medical Research, New Brunswick, New Jersey 08903-0191.
Nunn
A D
AD
Kuczynski
B L
BL
DiRocco
R J
RJ
Feld
T
T
Silva
D A
DA
Eckelman
W C
WC
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002560:Cerebrovascular Circulation; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D010091:Oximes / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D015609:Organotechnetium Compounds; D010091:Oximes; C065364:technetium Tc 99m-SQ 32097