title: [Effects of tachycardia on ischemic canine hearts during nitrous oxide-oxygen-halothane anesthesia].
abstract: Effects of tachycardia on left ventricular function, myocardial metabolism and intramyocardial pH under nitrous oxide-oxygen-halothane anesthesia, were studied in 11 canine hearts with critical coronary stenosis. A comparison was made with coronary occlusion. Critical stenosis was produced using a screw occluder to limit the left anterior descending coronary artery blood flow to prevent reactive hyperemia after 10 second occlusion. The degree of ischemia was estimated by intramyocardial pH, arterio-venous lactate and potassium. Intramyocardial pH was measured with a hydrogen ion-selective electrode implanted in the subendocardium. Tachycardia was induced by right cardiac sympathetic nerve stimulation. After 7 min tachycardia in dogs with coronary stenosis, intramyocardial pH decreased significantly from 7.09 +/- 0.10 to 6.83 +/- 0.15, then tended to return toward control levels over a period of 20 min after cessation of tachycardia, although some did not return to the control level even after 30 min. Regarding LV function, LVP and positive LV dp/dt max did not increase. Negative LV dp/dt max decreased significantly. The time constant (T) was prolonged but not significantly, while LVEDP rose considerably from 8.2 +/- 4.1 mmHg to 14.6 +/- 6.8 mmHg. In contrast, after 7 min occlusion, intramyocardial pH decreased significantly from 7.14 +/- 0.08 to 6.72 +/- 0.15 and recovered after 15 min. LVP decreased slightly. Positive and negative LV dp/dt max decreased significantly. T was not prolonged initially, but after reperfusion prolonged significantly. LVEDP increased significantly from 7.9 +/- 3.3 mmHg to 11.9 +/- 6.3 mmHg. In summary, tachycardia in dogs with coronary stenosis under nitrous oxide-oxygen-halothane anesthesia caused regional ischemia. The degree of ischemia was slightly less than with occlusion, but LV diastolic dysfunction was more prominent.
authors.affiliation: Department of Anesthesiology, Tokushima University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Kohyama
authors.forename: T
authors.initials: T
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Akazawa
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000769:Anesthesia, Inhalation; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006221:Halothane; D009609:Nitrous Oxide; D010100:Oxygen; D013610:Tachycardia / Q000150:complications*
chemical_list: D009609:Nitrous Oxide; D010100:Oxygen; D006221:Halothane