title: The pathogenesis of Pasteurella multocida serotype A:3,4 infection in turkeys: a comparison of two vaccine strains and a field isolate.
abstract: The pathogenesis of avian pasteurellosis caused by two vaccine strains, M-9 and Clemson University (CU), and a highly virulent field isolate, 86-1913, of Pasteurella multocida (serotype A:3,4) was studied in 7-week-old turkeys inoculated by an oculo-nasal-oral technique. Turkeys inoculated with strain CU and isolate 86-1913 developed severe progressive bacteremia that began at 4 hours postinoculation (PI) and peaked at 16-20 hours PI. Turkeys inoculated with strain CU and isolate 86-1913 had significantly higher concentrations of bacteria in blood and tissues, and greater histologic lesion scores for necrosis, heterophil infiltrates, and intralesional bacteria than turkeys inoculated with strain M-9. Immunohistochemical staining specific for P. multocida demonstrated numerous extracellular bacteria in tissues from turkeys inoculated with strain CU and isolate 86-1913. The mortality for turkeys inoculated with isolate 86-1913 was significantly higher than for turkeys receiving the two vaccine strains.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
authors.forename: M M
authors.initials: MM
authors.lastname: Prantner
authors.forename: B G
authors.initials: BG
authors.lastname: Harmon
authors.forename: J R
authors.initials: JR
authors.lastname: Glisson
authors.forename: E A
authors.initials: EA
authors.lastname: Mahaffey
mesh_terms: D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009336:Necrosis; D010325:Pasteurella / Q000472:pathogenicity*; D010326:Pasteurella Infections / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D011201:Poultry Diseases / Q000209:etiology* / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology / Q000662:veterinary; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014422:Turkeys; D014765:Viral Vaccines; D014774:Virulence
chemical_list: D014765:Viral Vaccines