[Detection of beta-lactamases in the Bacteroides fragilis group].
One hundred and thirty three strains of Bacteroides fragilis group isolated from clinical specimen were tested for beta-lactamase activity against five beta-lactam antibiotics, ampicillin, cefaloridin, cefuroxime, cefotaxime and cefoxitin. The Minimal Inhibitory Concentration of antibiotics was determined using the agar dilution method. Beta-lactamase production was detected by a microbiological method in 128 of the 133 (96%) strains. The detected beta-lactamases had a broad-spectrum activity, hydrolyzing both penicillins and cephalosporins (101 strains). Some strains had a wide activity against beta-lactam antibiotics, including cefoxitin (7 strains); among these strains, 3 were found hydrolyzing imipenem.
Martin
C
C
Laboratoire de Bactériologie, Centre Hospitalier d'Annecy.
Dubreuil
L
L
Sedallian
A
A
Romond
C
C
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001441:Bacteroides fragilis / Q000187:drug effects / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D066298:In Vitro Techniques; D007526:Isoelectric Point; D001618:beta-Lactamases / Q000032:analysis*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases
Détection des bêta-lactamases des Bacteroïdes du groupe fragilis.