title: Late-appearing Philadelphia chromosome in acute lymphoblastic leukemia.
abstract: We describe the cytogenetic analysis of a patient affected by a common acute lymphoblastic leukemia, L2 type. At diagnosis and first relapse, the karyotype was normal, whereas at the second relapse more than 60% of the examined cells showed a Philadelphia chromosome, without any change in the morphological and immunophenotypical picture. This case confirms the observation that leukemic cells are susceptible to developing a Ph, considered a primary chromosomal abnormality, during the course of the disease.
authors.affiliation: Cattedra di Clinica Medica R, Università di Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: R
authors.initials: R
authors.lastname: Defferrari
authors.forename: A
authors.initials: A
authors.lastname: Dejana
authors.forename: E
authors.initials: E
authors.lastname: Salvidio
mesh_terms: D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D013997:Time Factors
chemical_list: D005819:Genetic Markers