title: Adaptation of in vitro rat brain protein synthesis to long-term ingestion of n-butanol.
abstract: Long-term treatment of rats with n-butanol leads to a change in in vitro brain protein synthesis which increases the resistance of this process to either ethanol or isopropanol. The change seems to be related to ribosomal events since the synthesis of aminoacyl-tRNA was not affected in the same conditions.
authors.affiliation: Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Muñoz
authors.forename: J M
authors.initials: JM
authors.lastname: Ferreras
authors.forename: R
authors.initials: R
authors.lastname: Iglesias
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
authors.forename: T
authors.initials: T
authors.lastname: Girbés
mesh_terms: D020001:1-Butanol; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000440:Butanols / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010452:Peptide Biosynthesis; D010455:Peptides; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000440:Butanols; D009419:Nerve Tissue Proteins; D010455:Peptides; C012001:polyphenylalanine; D020001:1-Butanol; D008274:Magnesium