title: Endoscopic sclerosis of the gastric cardia for prevention of experimental gastroesophageal reflux.
abstract: Surgical anti-reflux therapy appears to involve the muscles of the proximal gastric cardia and those of the lower esophageal sphincter. In an experimental canine reflux model, we injected sclerosant solution into the submucosa of the proximal gastric cardia, hypothesizing that the subsequent fibrotic reaction might exert an anti-reflux effect. Reflux was induced by atropine infusion, and the amount of reflux was quantitated by pH monitoring. Endoscopic sclerosis was effective in preventing reflux induced by high-dose atropine. Because the length and pressure of the lower esophageal sphincter were unaffected by endoscopic treatment, reflux prevention was possibly related to enhancement of the gastric component of the reflux barrier.
authors.affiliation: Department of Surgery, University of Illinois, Chicago.
authors.forename: P E
authors.initials: PE
authors.lastname: Donahue
authors.forename: P J
authors.initials: PJ
authors.lastname: Carvalho
authors.forename: P E
authors.initials: PE
authors.lastname: Davis
authors.forename: Y J
authors.initials: YJ
authors.lastname: Shen
authors.forename: I
authors.initials: I
authors.lastname: Miidla
authors.forename: C T
authors.initials: CT
authors.lastname: Bombeck
authors.forename: L M
authors.initials: LM
authors.lastname: Nyhus
mesh_terms: D000818:Animals; D001285:Atropine; D002299:Cardia; D004195:Disease Models, Animal; D004285:Dogs; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D005773:Gastroscopy; D006863:Hydrogen-Ion Concentration; D008991:Monitoring, Physiologic; D011312:Pressure; D012597:Sclerosing Solutions / Q000627:therapeutic use*
chemical_list: D012597:Sclerosing Solutions; D001285:Atropine