title: Psychopathological and neuropsychological symptoms in patients with subclinical and remitted hyperthyroidism.
abstract: To investigate relationships between hyperthyroidism and behavior, 45 formerly hyperthyroid patients (now euthyroid) and 51 control subjects were investigated by (a) a semi-structured psychiatric examination, (b) self-rating scales to assess mood states and personality, and (c) neuropsychological tests. Patients with "subclinical" or "remitted" hyperthyroidism showed more abnormalities than the controls in all dimensions investigated. Forty-three percent of patients (10% of controls) complained of "seriously reduced" well-being with feelings of fear, hostility, and inability to concentrate. While a fearful-agitated syndrome dominated in the initial phase of the illness, a mainly depressive syndrome was characteristic after a longer period of remission. More than 25% of the patients (2% of controls) showed "markedly impaired" neuropsychological functioning. Patients with a relapse within 2.5 years exhibited the most abnormal results. Even after a longer period of hormonal remission, there was no complete psychopathological and neuropsychological normalization. A thorough follow-up of hyperthyroid patients is recommended.
authors.affiliation: Psychiatrische Klinik Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Bommer
authors.forename: T
authors.initials: T
authors.lastname: Eversmann
authors.forename: R
authors.initials: R
authors.lastname: Pickardt
authors.forename: A
authors.initials: A
authors.lastname: Leonhardt
authors.forename: D
authors.initials: D
authors.lastname: Naber
mesh_terms: D000236:Adenoma / Q000523:psychology; D000328:Adult; D000368:Aged; D005260:Female; D006111:Graves Disease / Q000523:psychology; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000523:psychology*; D009483:Neuropsychological Tests; D013963:Thyroid Hormones / Q000097:blood; D013964:Thyroid Neoplasms / Q000523:psychology
chemical_list: D013963:Thyroid Hormones