title: Prolymphocytic leukemia treated with natural and recombinant alpha-interferon.
abstract: The patient was a 65 year old woman with a massive splenomegaly and no lymphoadenopathy. An electron microscopic study of the peripheral blood cells revealed that these cells were prolymphocytes with a single large nucleolus. Treatment with native and recombinant alpha-interferon has produced an impressive reduction in spleen size and in the count of prolymphocytes.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Terashima
authors.forename: K
authors.initials: K
authors.lastname: Ohtake
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D002466:Cell Nucleolus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D015463:Leukemia, Prolymphocytic / Q000150:complications / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D011994:Recombinant Proteins; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins