title: Liver-lesion tissue contrast on MR images: effect of iron oxide concentration and magnetic field strength.
abstract: This study assessed the enhancement of liver-lesion contrast by using low levels of iron oxide contrast agent at four common magnetic resonance (MR) imaging field strengths: 0.15, 0.35, 0.5, and 1.5 T. Adenocarcinomas were percutaneously inserted into the livers of 15 rats. Iron oxide was given intravenously in concentrations of 0 (control group), 2.5, 5, 10, and 20 mumol/kg to three rats in each concentration group. All images were acquired between 1 and 24 hours after injection. Liver-lesion contrast ratios and contrast-to-noise ratios (C/Ns) were calculated. Results showed increased liver-lesion contrast and C/Ns with increased iron oxide concentration up to 10-20 mumol/kg at all four magnetic field strengths. At 0.15 T, iron oxide produced lower gains in tumor-liver contrast. At middle and high magnetic field strengths, liver-lesion contrast was similar for each level of iron oxide concentration, but C/Ns were markedly higher at 1.5 T than at middle field strength. Low levels of iron oxide contrast agent are effective at magnetic field strengths of 0.35 T and above, producing the greatest increase in C/N at middle field strengths.
authors.affiliation: Department of Radiology, University of Colorado Health Sciences Center, Denver 80262.
authors.forename: D
authors.initials: D
authors.lastname: Thickman
authors.forename: R E
authors.initials: RE
authors.lastname: Hendrick
authors.forename: K A
authors.initials: KA
authors.lastname: Jerjian
authors.forename: C S
authors.initials: CS
authors.lastname: Schanker
mesh_terms: D000818:Animals; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D007501:Iron / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D010087:Oxides; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D003287:Contrast Media; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide