Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.
The alpha B-crystallin gene (CRYA2) encodes the abundant lens protein alpha B-crystallin. A panel of human/rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster alpha B-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.
Brakenhoff
R H
RH
Department of Molecular Biology and Cell Biology, University of Nijmegen, The Netherlands.
Guerts van Kessel
A H
AH
Oldenburg
M
M
Wijnen
J T
JT
Bloemendal
H
H
Meera Khan
P
P
Schoenmakers
J G
JG
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003459:Crystallins / Q000235:genetics*; D006801:Humans
D003459:Crystallins