title: [Effectiveness of immunostimulants in nonspecific ulcerative colitis].
abstract: Clinical and immunologic efficacies of some immunostimulants (levamisole, sodium nucleinate, thymic preparations) included in therapeutic schemes in nonspecific ulcerous colitis both separately and in various combinations were under study. The efficacy of these stimulants was found to depend on the disease severity and proved to be the highest in the light course. Thymalin and sodium nucleinate showed the highest clinical and immunologic efficacies, particularly if used together. Levamisole administration was associated with frequent side effects and had no essential advantages over basic therapy. This permits a conclusion that immunostimulants are pathogenetically validated in therapy of ulcerous colitis, for they result in reduction or elimination of immunity insufficiency and their administration leads to a positive clinical effect in the majority of cases.
authors.forename: V G
authors.initials: VG
authors.lastname: Perederiĭ
authors.forename: S M
authors.initials: SM
authors.lastname: Tkach
authors.forename: N G
authors.initials: NG
authors.lastname: Bychkova
authors.forename: I L
authors.initials: IL
authors.lastname: Blazhenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000276:immunology; D004341:Drug Evaluation; D006801:Humans; D007978:Levamisole / Q000009:adverse effects / Q000627:therapeutic use; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009696:Nucleic Acids / Q000627:therapeutic use; D012397:Rosette Formation; D013951:Thymus Hormones / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D013951:Thymus Hormones; D007978:Levamisole; C032805:thymalin; C013683:sodium nucleinate
vernacular_title: Effektivnost' immunostimuliruiushchikh sredtstv pri nespetsificheskom iazvennom kolite.