[Spectroscopic properties of the partial beta-agonist doxaminol (BM 10.188) and its metabolites].
The biotransformation of the positively inotropically active compound N-methyl-N-(2-hydroxy-3-phenoxy-propyl)-11-(2-aminoethyl)-6,11- dihydrodibenz[b,e]-oxepine, neutral fumarate, (Doxaminol, racemic mixture of diastereomeres) in dogs is examined. The metabolits M1-M7 were isolated and their chemical structures identified by 1H-NMR, 13C-NMR and mass spectroscopic methods. 2-Hydroxy-3-phenoxypropionic acid, phenoxyacetic acid, 3-(4'-hydroxy)-phenoxy-1,2-propandiol and phenylacetic acid were formed by side chain oxidation of the parent molecule. Furthermore, the following conjugates were characterized: Doxaminol-O-glucuronide, 4'-hydroxydoxaminol-O-glucuronide, and 1-hydroxy-3-phenoxy-2-propyl sulfate.
Neidlein
R
R
Pharmazeutisch-Chemisches Institut, Universität Heidelberg.
Volland
C
C
Kramer
W
W
D001711:Biotransformation; D003990:Dibenzoxepins / Q000032:analysis* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy
D003990:Dibenzoxepins; C034187:doxaminol
Spektroskopische Eigenschaften des partiellen beta-agonisten Doxaminol (BM 10.188) und seiner Stoffwechselprodukte.