[The role of lipid metabolic disorders in the development of eczema and psoriasis in chronic alcoholism (clinical and experimental research)].
Blood plasma and red-cell neutral lipid spectrum and red-cell phospholipid spectrum were examined in patients with eczema and psoriasis who abused and did not abuse alcohol. Time course of these parameters was studied in guinea pigs in various periods of chronic alcoholization. Chronic alcoholization was found to be associated with manifest lipid metabolism disorders, the most characteristic shifts being evaluated membrane concentration of free cholesterol and increased level of lisophosphatidylcholin, a membranotoxic agent, as well as reduction of polyunsaturated fatty acid level in phospholipids; these factors may aggravate the course of allergic dermatoses and psoriasis.
Lashmanova
A P
AP
Tsagareĭshvili
K A
KA
D000437:Alcoholism / Q000097:blood / Q000150:complications*; D000818:Animals; D004485:Eczema / Q000097:blood / Q000209:etiology*; D004912:Erythrocytes / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D008055:Lipids / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D011565:Psoriasis / Q000097:blood / Q000209:etiology*
D008055:Lipids; D010743:Phospholipids
Rol' narusheniĭ lipidnogo obmena v razvitii ékzemy i psoriaza pri khronicheskom alkogolizme (kliniko-éksperimental'noe issledovanie).