title: Papillary tumour of the vagina resembling transitional cell carcinoma.
abstract: A case of a peculiar papillary neoplasia of the vagina resembling a urothelial tumour is presented. Four vaginal tumours were excised from a 76-year-old woman. Five years before this patient had undergone a uretero-nephrectomy for a non-invasive papillary transitional cell carcinoma of the renal pelvis. The four vaginal tumours demonstrated gross and microscopic similarities to low-grade papillary transitional cell carcinoma of the urinary tract. This observation indicates that multicentric, non-invasive, papillary tumours may affect the whole uro-genital area. The vaginal wall was not overlaid by a normal squamous epithelium, but by a peculiar "transitional-like" epithelium. Variegated endocrine cells were documented within this lining, using immunohistochemical and ultrastructural techniques. The eventuality of a histogenetic link between the tumour and the adjacent epithelial lining remains unresolved.
authors.affiliation: Laboratoire d'Anatomie pathologique, Faculté de Médecine, Tours, France.
authors.forename: F
authors.initials: F
authors.lastname: Fetissof
authors.forename: O
authors.initials: O
authors.lastname: Haillot
authors.forename: Y
authors.initials: Y
authors.lastname: Lanson
authors.forename: B
authors.initials: B
authors.lastname: Arbeille
authors.forename: J
authors.initials: J
authors.lastname: Lansac
mesh_terms: D000368:Aged; D001839:Bombesin / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002864:Chromogranins / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D014625:Vaginal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D002864:Chromogranins; D012701:Serotonin; D010751:Phosphopyruvate Hydratase; D001839:Bombesin