The accumulation of 11C-methionine in cerebral glioma patients studied with PET.
Fourteen patients with cerebral gliomas were studied with positron emission tomography (PET) using L-[methyl-11C]methionine (11C-MET). Positive images of tumour were obtained in all cases regardless of histological grades. The analysis of differential absorption ratio (DAR) showed the higher accumulation of 11C-MET in high grade gliomas than in low grade gliomas. PET study with 11C-MET will be of great value not only in delineating the location of gliomas, but also in making a qualitative diagnosis from the view point of the biological properties of gliomas.
Kameyama
M
M
Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
Shirane
R
R
Itoh
J
J
Sato
K
K
Katakura
R
R
Yoshimoto
T
T
Hatazawa
J
J
Itoh
M
M
Ido
T
T
D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D002250:Carbon Radioisotopes; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D008715:Methionine / Q000378:metabolism; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D008715:Methionine