[The effect of OK-432 on modifying a spontaneous lung metastasis from murine fibrosarcomas].
The authors have investigated the effect of OK-432 on the spontaneous metastasis from a murine fibrosarcoma, either an NFSA or a SANH, that had been transplanted into the right thigh of C3H mice. When the NFSA or the SANH tumors grew to 7 mm in diameter, they were irradiated with a single dose of 30 Gy and 20 Gy, respectively. A local administration of OK-432 (2.5 KE) around each of the tumors was initiated immediately after irradiation and continued twice a week. It was found that regrowth in both tumors was not modified by the OK-432, though the mean number of metastatic lung nodules per mouse from either tumor was significantly decreased. The incidence of a lung metastasis also was reduced by the OK-432 but not significantly. Further, mice that had received a SANH tumor transplant developed a lymph node metastasis in the abdominal cavity that was depressed by the OK-432.
Ito
H
H
Dept. of Radiology, Keio Univ. School of Med.
Yamada
S
S
Nishiguchi
I
I
Shigematsu
N
N
Nakayama
T
T
Kuribayashi
T
T
Hashimoto
S
S
D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005354:Fibrosarcoma / Q000473:pathology / Q000532:radiotherapy*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010844:Picibanil / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism*
D001688:Biological Products; D000514:alpha 1-Antichymotrypsin; D010844:Picibanil