A comparative study of manganese meso-sulfonatophenyl porphyrins: contrast-enhancing agents for tumors.
Four manganese meso-sulfonatophenyl porphyrins were prepared, characterized and investigated for their potential as tumor-specific MRI contrast-enhancing agents in mice bearing subcutaneous implants of a mammary carcinoma (SMT-F). The trisulfonated tetraphenyl porphyrin, MnTPPS3 presented the most favorable profile: bio-distribution, tumor concentration and tumor relaxivity, when compared at 24 hr postinjection. Imaging experiments revealed that a time-dependent delineation of tumor morphology occurs in response to MnTPPS3 that appears to correlate with necrotic regions of the tumor.
Fiel
R J
RJ
Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York 14263.
Musser
D A
DA
Mark
E H
EH
Mazurchuk
R
R
Alletto
J J
JJ
D000818:Animals; D002277:Carcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D004341:Drug Evaluation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008665:Metalloporphyrins; D051379:Mice; D009132:Muscles / Q000378:metabolism; D009336:Necrosis; D011166:Porphyrins / Q000145:classification / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D008665:Metalloporphyrins; D011166:Porphyrins; C056661:manganese(III)tetraphenylporphine sulfonate