title: Comparison of flurbiprofen and acetaminophen with codeine in postoperative foot pain.
abstract: The purpose of this double-blind, randomized, parallel, multiple-dose study was to compare the efficacy and safety of flurbiprofen with acetaminophen with codeine phosphate in the 96-hr postoperative period following foot surgery. Analysis of mean pain intensity and mean pain relief for the patients not requiring rescue medication did not reveal any significant differences between treatment groups. There were also no significant differences between treatment groups with respect to patient and investigator global evaluations of therapy. The incidence of termination of the study because of side effects was higher for the acetaminophen with codeine group.
authors.affiliation: American College of Foot Surgeons, Augusta, GA.
authors.forename: M L
authors.initials: ML
authors.lastname: Ottinger
authors.forename: K W
authors.initials: KW
authors.lastname: Kinney
authors.forename: J R
authors.initials: JR
authors.lastname: Black
authors.forename: M
authors.initials: M
authors.lastname: Wittenberg
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D003061:Codeine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005480:Flurbiprofen / Q000009:adverse effects / Q000627:therapeutic use*; D005528:Foot / Q000601:surgery*; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D000082:Acetaminophen; D005480:Flurbiprofen; D003061:Codeine