[Coincidental occurrence of idiopathic thrombocytopenic purpura in a patient with familial von Willebrand disease].
A very rare case with coincidental idiopathic thrombocytopenic purpura (ITP) and familial von Willebrand disease (vWD) was reported. A 23-year-old female was admitted because of unusual bleeding tendency lasting still after the remission of thrombocytopenic state associated with ITP. Coagulation studies indicated the presence of a mild vWD, which was thought to be responsible for the bleeding tendency. The qualitative analysis of von Willebrand factor by crossed immunoelectrophoresis and SDS-1.2% agarose gel electrophoresis showed normal multimeric composition compatible with type I vWD. vWF-inhibitor was negative, and family study revealed that her mother was also affected with type I vWD. These results suggested that there was no immediate causal relation between the two disease states. The prevalence of concomitant disease states with ITP and vWD was discussed.
Shinmyozu
K
K
Division of Internal Medicine, Kagoshima City Hospital, Japan.
Tara
M
M
Okadome
T
T
Maruyama
Y
Y
Maruyama
I
I
Osame
M
M
D000328:Adult; D005260:Female; D006801:Humans; D010375:Pedigree; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000601:surgery; D013156:Splenectomy; D014842:von Willebrand Diseases / Q000150:complications / Q000235:genetics*