title: [Preclinical and clinical studies on aztreonam in pediatric surgery].
abstract: Aztreonam (AZT) was administered to immature infants, neonates and infants for preclinical and clinical studies. 1. Sufficient serum concentrations were obtained upon 1-hour intravenous drip infusion of AZT 40 mg/kg to infants with biliary atresia. The average T1/2 was about 1 hour and urinary recovery rates were in a range between 35.2 and 61.3%. Biliary recovery rates were 0.03-0.4%. 2. AZT was given to 5 cases for prophylaxis and the results showed its prophylactic effect in 3 cases. 3. AZT is effective against Gram-negative bacteria and its efficacies in the treatment of 4 infection-cases were "excellent" in 2 cases and "effective" and "somewhat effective" in 1 case each. 4. Neither side effects nor abnormal laboratory test values were observed in any of the 9 cases given AZT.
authors.affiliation: Department of Pediatric Surgery, Juntendo University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Shimomura
authors.forename: T
authors.initials: T
authors.lastname: Miyano
authors.forename: K
authors.initials: K
authors.lastname: Kimura
mesh_terms: D001398:Aztreonam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D001646:Bile / Q000378:metabolism; D001656:Biliary Atresia / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D007262:Infusions, Intravenous; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication
chemical_list: D001398:Aztreonam