title: Acceleration of conduction within an accessory pathway with propafenone.
abstract: We describe a case of dangerous acceleration of conduction through an accessory pathway produced by the Class IC agent propafenone during routine electrophysiological study of a patient with Wolff-Parkinson-White syndrome. This pro-arrhythmic effect has not previously been described with this drug. Propafenone is now being more widely used since the publication of the preliminary results of the CAST Study in the U.S.A.
authors.affiliation: Department of Cardiology, Guy's Hospital, London, U.K.
authors.forename: A N
authors.initials: AN
authors.lastname: Sulke
authors.forename: P
authors.initials: P
authors.lastname: Holt
authors.forename: G E
authors.initials: GE
authors.lastname: Sowton
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000139:chemically induced*; D001282:Atrial Flutter / Q000139:chemically induced*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D011405:Propafenone / Q000009:adverse effects*; D014927:Wolff-Parkinson-White Syndrome / Q000175:diagnosis
chemical_list: D011405:Propafenone