title: [15N tracer technical studies of protein metabolism in arteriosclerosis patients].
abstract: The incorporation of the stable isotope 15N in plasma proteins and blood cells after oral application of 3 g 15NH4Cl (95 At% 15N) per 70 kg body weight was followed up in 11 patients with ischemic heart disease or peripheral arteriosclerosis and in 7 healthy control subjects. Preliminary results indicate that the turnover of plasma protein, especially fibrin, is elevated in patients with arteriosclerosis. Investigations of platelets intimate a decreased turnover of platelet protein in patients with arteriosclerosis as compared to control subjects. Possible reasons for these alterations are discussed.
authors.affiliation: Zentralinstitut für Herz-Kreislauf-Forschung, AdW der DDR, Berlin-Buch.
authors.forename: H
authors.initials: H
authors.lastname: Barleben
authors.forename: C
authors.initials: C
authors.lastname: Wagenknecht
authors.forename: K
authors.initials: K
authors.lastname: Jung
authors.forename: L
authors.initials: L
authors.lastname: Junker
authors.forename: H
authors.initials: H
authors.lastname: Reimann
authors.forename: K
authors.initials: K
authors.lastname: Hamann
authors.forename: H
authors.initials: H
authors.lastname: Heine
mesh_terms: D001161:Arteriosclerosis / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood*; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009590:Nitrogen Radioisotopes; D012016:Reference Values
chemical_list: D001798:Blood Proteins; D009590:Nitrogen Radioisotopes; D005337:Fibrin
vernacular_title: 15N-Tracertechnische Untersuchungen zum Eiweissstoffwechsel bei Arteriosklerosepatienten.