Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports.
The report of a putative schizophrenia susceptibility gene linked to markers in the chromosome 5q11-q13 region and subsequent failures of replication have provoked considerable controversy. We here report six Welsh families multiply affected with schizophrenia in which there is no evidence for linkage between a dominant-like schizophrenia gene and 5q11-q13 markers. It is argued that our new results together with a combined reanalysis of previous studies suggest that a schizophrenia susceptibility gene can be excluded from the 5q11-q13 region. The apparent disparities between published results are most likely to reflect a chance finding in the one positive study and probably should not be interpreted as resulting from true linkage heterogeneity.
McGuffin
P
P
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
Sargeant
M
M
Hetti
G
G
Tidmarsh
S
S
Whatley
S
S
Marchbanks
R M
RM
D002895:Chromosomes, Human, Pair 5; D015342:DNA Probes; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*; D014852:Wales
D015342:DNA Probes; D005819:Genetic Markers