title: Selective variceal decompression and its role relative to other therapies.
abstract: Seventy patients, selected from 265 patients with proved variceal bleeding, underwent a distal splenorenal shunt (DSRS) procedure with or without splenopancreatic disconnection (SPD). Alcoholic cirrhosis was the cause of portal hypertension in 57% of the patients. The operative mortality was 13% (Child's classes A and B 2%, class C 66%). Despite fewer varices in all of the patients, variceal rebleeding and death occurred in one patient (2%). Late portal perfusion was observed in 91% of the patients, with worsening in 23%, compared with the preoperative study. Persistent hepatocyte necrosis and incomplete SPD were the most significant prognostic factors for decreased perfusion (presence and absence of necrosis, 38% and 12%, respectively; DSRS and DSRS with SPD, 43% and 12%, respectively). SPD also decreased ongoing hepatocyte damage. Post-shunt encephalopathy was clinically evident in 7% of the patients, but after electroencephalographic evaluation, it increased to 24.6%. Significant factors in its development included decreased portal perfusion (62% versus 14%), active hepatitis (48% versus 17%), and incomplete SPD (43% versus 14%). The higher late liver-related mortality was associated with a lack of or decreased portal perfusion and the absence of SPD.
authors.affiliation: Institute of Second Surgical Pathology, University of Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Maffei-Faccioli
authors.forename: G E
authors.initials: GE
authors.lastname: Gerunda
authors.forename: D
authors.initials: D
authors.lastname: Neri
authors.forename: R
authors.initials: R
authors.lastname: Merenda
authors.forename: F
authors.initials: F
authors.lastname: Zangrandi
authors.forename: F
authors.initials: F
authors.lastname: Meduri
mesh_terms: D004932:Esophageal and Gastric Varices / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000601:surgery*; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013164:Splenorenal Shunt, Surgical / Q000009:adverse effects / Q000379:methods