Detection of somatotropin receptors on human monocytes.
The expression of somatotropin receptors on human peripheral blood monocytes was investigated. Binding of [125I]somatotropin to human monocytes was found to be specific and saturable. The binding was rapid and time-dependent, and was abolished by pretreatment of monocytes with trypsin. Scatchard plot analysis revealed that each cell bore more than 8 x 10(3) binding sites with an affinity constant of 1 x 10(8) M-1.
Jafari
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Immunobiological Laboratories, Inc., New York, NY.
Khansari
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D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000032:analysis*; D011485:Protein Binding; D011986:Receptors, Somatotropin / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D014357:Trypsin / Q000494:pharmacology
D011986:Receptors, Somatotropin; D013006:Growth Hormone; D014357:Trypsin