title: Influence of glycine on morphine-induced antinociception in mice.
abstract: The effects of glycine on morphine-induced antinociception were investigated in mice, using a cutaneous thermal test (hot-plate), a visceral chemical test (acetylcholine writhing test), and a locomotor activity test. When glycine (200 mg/kg p.o.) and morphine (5 mg/kg s.c.) were given together during the first 30 min, glycine first antagonized the morphine-induced antinociception then this was followed by a synergistic effect. The two-phase influence of glycine on morphine-induced antinociception may be due to the interaction of glycine with different receptors.
authors.affiliation: Department of Pharmacology, University of Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Carrara
authors.forename: S
authors.initials: S
authors.lastname: Zampiron
authors.forename: F
authors.initials: F
authors.lastname: Capolongo
authors.forename: L
authors.initials: L
authors.lastname: Cima
authors.forename: P
authors.initials: P
authors.lastname: Giusti
mesh_terms: D000109:Acetylcholine; D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D005998:Glycine / Q000494:pharmacology*; D006358:Hot Temperature; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity; D010146:Pain / Q000139:chemically induced
chemical_list: D000700:Analgesics; D009020:Morphine; D000109:Acetylcholine; D005998:Glycine