title: [The contraceptive activity of triterpene glycosides--the total sum of holotoxins A1 and B1 and holothurin A in an experiment].
abstract: The sum of triterpene glycosides of the Far Eastern holothurian Stichopus japonicus Selenka (holotoxins A1 and B1) possesses the contraceptive activity. Glycoside holoturin A of the tropical holothurian Holoturia atra lacks these properties. The action of the sum of holotoxins is based on the estrogenic activity which was demonstrated both in the uterotropic and vaginotropic tests. The drug under study suppresses ovulation and stimulates the contractile activity of the uterus.
authors.forename: M N
authors.initials: MN
authors.lastname: Mats
authors.forename: V V
authors.initials: VV
authors.lastname: Korkhov
authors.forename: V R
authors.initials: VR
authors.lastname: Stepanov
authors.forename: E V
authors.initials: EV
authors.lastname: Kupera
authors.forename: G K
authors.initials: GK
authors.lastname: Oleĭnikova
authors.forename: M M
authors.initials: MM
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004447:Echinodermata; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006697:Holothurin / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D012616:Sea Cucumbers; D013737:Testis / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
chemical_list: D003281:Contraceptives, Postcoital; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; D006697:Holothurin; C034723:holothurin A; C001883:stichoposide
vernacular_title: Kontratseptivnaia aktivnost' triterpenovykh glikozidov--summy golotoksina A1 i B1 i goloturina A v éksperimente.