Correlation between cocaine-induced locomotion and cocaine disposition in the brain among four inbred strains of mice.
BALB/cByJ, C57BL/6ByJ, CXBH/By, and CXBK/By mice differed in their locomotor response to cocaine measured 1-10 min after administration of 25 mg/kg IP of the compound. These differences were paralleled by differences in the disposition of cocaine (measured at 12 min) in the brain. Among all individual animals taken together, there was a significant correlation between locomotor stimulation and the brain concentration of cocaine. These results suggest that the differences between strains in their locomotor responsiveness to cocaine are determined, in part, by the disposition of cocaine in the brain following IP administration of cocaine.
Wiener
H L
HL
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY 11439.
Reith
M E
ME
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003042:Cocaine / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D013045:Species Specificity; D014018:Tissue Distribution
D003042:Cocaine