In vivo effect of molybdenum on benzo(a)pyrene metabolism in liver and lung rat microsomes.
Lung and liver microsomal fractions of rats treated by 40 or 80 mg/kg/day of ammonium heptamolybdate for a period of 8 weeks showed a decrease in the different B(a)P metabolites assessed by high-performance liquid chromatography analysis. When the rats were induced by 3-methylcholanthrene 48 hours before the sacrifice, only the decrease in lung microsomal B(a)P metabolites formation persisted. It is suggested that, by inhibiting the cytochrome P450-dependent monooxygenase activity, Mo could have an influence on the incidence of B(a)P-induced cancer in lung which constituted the target organ for polycyclic aromatic hydrocarbon.
Bompart
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INSERM U 133, Faculté de Médecine, Toulouse, France.
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D008168:Lung / Q000648:ultrastructure*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008982:Molybdenum / Q000494:pharmacology*; D010105:Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D065607:Cytochrome P-450 Enzyme Inhibitors; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D008982:Molybdenum; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C022175:ammonium molybdate