title: [The action of cyclophosphane in different morphological variants of glomerulonephritis in mice].
abstract: Heterologous serum glomerulonephritis (GN) was induced in CBA and C57BL mice. CBA mice developed diffuse proliferative GN. Glomerular changes in C57BL mice corresponded to the mesangial GN with proliferation of glomerular mesangial cells and mesangial infiltration with mononuclear phagocytes. Single administration of cyclophosphamide (CP) at the time of immunization exerted different effect on the development of the two morphological variants of GN. In CBA mice CP treatment resulted in disappearance of the immune complexes deposits with no influence on the cell reactions. In C57BL mice CP completely inhibited the development of the glomerular morphological changes. The lack of morphological similarity is most likely connected with the immunological differences in the histocompatibility complex (H-2).
authors.forename: D V
authors.initials: DV
authors.lastname: Samoĭlov
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.forename: O P
authors.initials: OP
authors.lastname: Gladskikh
authors.forename: T N
authors.initials: TN
authors.lastname: Krasnova
authors.forename: E M
authors.initials: EM
authors.lastname: Shilov
authors.forename: M A
authors.initials: MA
authors.lastname: Pal'tsev
authors.forename: I E
authors.initials: IE
authors.lastname: Tareeva
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D003520:Cyclophosphamide / Q000633:toxicity*; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007114:Immunization / Q000379:methods; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010949:Plasma / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D003520:Cyclophosphamide
vernacular_title: Deĭstvie tsiklofosfana pri razlichnykh morfologicheskikh variantakh glomerulonefrita mysheĭ.