Human T-cell lymphotropic virus type I (HTLV-I) antibodies in pre-diagnostic serum of patients with familial adult T-cell leukemia/lymphoma (ATL).
In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non-Hodgkin's lymphoma were identified after a follow-up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T-cell leukemia/lymphoma (ATL). Both of these brothers had human T-cell lymphotropic virus type I (HTLV-I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV-I antibody positive. This finding lends further support for a role of HTLV-I in the etiology of adult T-cell leukemia/lymphoma.
Nomura
A M
AM
Kuakini Medical Center, Honolulu, HI 96817.
Yanagihara
E T
ET
Blattner
W A
WA
Ho
G Y
GY
Inamasu
M S
MS
Severson
R K
RK
Nakamura
J M
JM
D000368:Aged; D015481:HTLV-I Antibodies / Q000032:analysis*; D006254:Hawaii; D006801:Humans; D007564:Japan / Q000208:ethnology; D007938:Leukemia / Q000382:microbiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000235:genetics; D008223:Lymphoma / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000382:microbiology*
D015481:HTLV-I Antibodies