[Dimethyl sulfoxide as a corrector of disorders of cerebral hemodynamics, oxygen and carbohydrate metabolism of the brain and lipid peroxidation in the early period after intracerebral hemorrhage].
Intraperitoneal injection of DMSO (0.7 g/kg) in rats 1h after intracerebral hemorrhage prevented brain conjugated diens and fluorosciene products increase and limited cerebral ++anti-radical activity. In experiments on cats 1h after intracerebral hemorrhage intravenous infusion of DMSO (0.3 g/kg) for 30 min improved cerebral hemodynamic, oxygen and glucose metabolism; cats mortality was decreased.
Plotnikov
M B
MB
Avdoshin
A D
AD
Chernysheva
G A
GA
Saratikov
A S
AS
D000818:Animals; D000975:Antioxidants; D001921:Brain / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002415:Cats; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D004121:Dimethyl Sulfoxide
Dimetilsul'foksid kak korrektor narusheniia tserebral'noĭ gemo- dinamiki, kislorodnogo i uglevodnogo metabolizma mozga i lipidnoĭ peroksidatsii v rannie sroki posle vnutrimozgovogo krovoizliianiia.