title: Prevention of posterior capsular opacification by cryolysis and the use of heparinized irrigating solution during extracapsular lens extraction in rabbits.
abstract: We tried applying a specially-designed cryoprobe to the posterior capsule as well as adding heparin, an anticoagulative, anti-inflammatory compound, to the anterior chamber irrigation solution in an attempt to inhibit secondary cataract formation following a planned extracapsular lens extraction in 36 rabbits. The first group received both cryo treatment and heparin; a second group received heparin without cryo treatment; a third group received neither heparin nor cryo treatment. Complete opacification of the lens developed 3 months after the operation in all the rabbits not treated with heparin, and in 50% of those that received heparin. The addition of cryo treatment to the heparin-treated rabbits further reduced opacification by 20%. We conclude that in rabbits, cryo treatment, combined with intracameral administration of heparin during surgery, has a significant inhibitory effect on secondary cataract formation.
authors.affiliation: Maurice and Gabriela Goldschleger Eye Research Institute, Chaim Sheba Medical Center, Tel Aviv University, Sackler Faculty of Medicine, Tel Hashomer, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Zaturinsky
authors.forename: N
authors.initials: N
authors.lastname: Naveh
authors.forename: D
authors.initials: D
authors.lastname: Saks
authors.forename: A S
authors.initials: AS
authors.lastname: Solomon
mesh_terms: D000818:Animals; D002386:Cataract / Q000517:prevention & control*; D003452:Cryosurgery; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use*; D007908:Lens, Crystalline / Q000601:surgery*; D008297:Male; D011817:Rabbits; D007507:Therapeutic Irrigation
chemical_list: D006493:Heparin