Dietary K determines NaCl sensitivity in NaCl-induced rises of blood pressure in spontaneously hypertensive rats.
The current study tested whether the spontaneously hypertensive rats (SHR) from Charles River Laboratories are resistant or not to NaCl-induced rises of blood pressure and stroke deaths. These rats are fairly NaCl-resistant on a 2.1% high K diet, whereas they are quite susceptible to NaCl-induced hypertension and stroke deaths on a 0.5% normal K diet. Thus, a high K diet strongly protects against an NaCl-induced rise of blood pressure as well as stroke deaths in these SHR rats. Hence the level of dietary K determines the degree of NaCl sensitivity in these SHR rats.
Ganguli
M
M
Department of Medicine, University of Minnesota Hospital, School of Medicine, Minneapolis 55455.
Tobian
L
L
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000139:chemically induced / Q000401:mortality; D004032:Diet; D008297:Male; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D012965:Sodium Chloride; D011188:Potassium