title: [Anesthesiologic and intensive care aspects of severe pre-eclampsia with HELLP syndrome].
abstract: From 1984 to 1988 22 patients with preeclampsia and HELLP syndrome were treated in our ICU. The HELLP syndrome is defined as preeclampsia complicated by thrombocytopenia, hemolysis and disturbed liver function. 3 patients developed a severe DIC with consumption of hemostatic potential. One patient died in multiorgan failure having a consumption coagulopathy, liver rupture and renal failure. To prevent severe hemostatic complications, it is essential to start therapy of DIC as soon as possible by inhibition of the activated coagulation system. Bleeding caused by blood coagulation disorders can occur spontaneously and during operative treatment. Epidural or spinal anaesthesia should be avoided in patients with HELLP syndrome. Because of severe complications such as respiratory failure, diffuse bleeding caused by DIC and progressive deterioration of the renal and liver function in most of the cases, patients with HELLP syndrome require a close cooperation between obstetrics and anesthesist.
authors.affiliation: Zentrum Anaesthesiologie, Georg-August-Universität Göttingen.
authors.forename: J
authors.initials: J
authors.lastname: Rathgeber
authors.forename: W
authors.initials: W
authors.lastname: Rath
authors.forename: J U
authors.initials: JU
authors.lastname: Wieding
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy; D000328:Adult; D000743:Anemia, Hemolytic / Q000601:surgery*; D000773:Anesthesia, Obstetrical / Q000379:methods*; D001780:Blood Coagulation Tests; D001803:Blood Transfusion; D002585:Cesarean Section; D003422:Critical Care / Q000379:methods*; D004211:Disseminated Intravascular Coagulation / Q000628:therapy; D005260:Female; D006501:Hepatic Encephalopathy / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008111:Liver Function Tests; D017713:Platelet Transfusion; D011183:Postoperative Complications / Q000628:therapy; D011225:Pre-Eclampsia / Q000601:surgery*; D011247:Pregnancy; D013577:Syndrome; D013921:Thrombocytopenia / Q000601:surgery*
vernacular_title: Anästhesiologische und intensivmedizinische Aspekte der schweren Präeklampsie mit HELLP-Syndrom.