title: Degradation of human cartilage by monocytes.
abstract: The effect of human peripheral blood monocytes on the degradation of human articular cartilage was studied in vitro using a radiometric assay to detect proteoglycan breakdown. The results showed that proteoglycan breakdown was increased by 60% after a 20 h exposure to monocytes (p less than 0.001).
authors.affiliation: Department of Immunology, Adelaide Children's Hospital, North Adelaide, South Australia.
authors.forename: L M
authors.initials: LM
authors.lastname: Kumaratilake
authors.forename: I C
authors.initials: IC
authors.lastname: Kowanko
authors.forename: E J
authors.initials: EJ
authors.lastname: Bates
authors.forename: A
authors.initials: A
authors.lastname: Ferrante
mesh_terms: D002358:Cartilage, Articular / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D011509:Proteoglycans