title: Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs.
abstract: This study was undertaken to delineate the role of cholecystokinin (CCK) in bombesin- and meal-stimulated pancreatic polypeptide (PP) secretion in seven conscious dogs by studying: (1) the stimulatory effect of similar plasma levels of CCK induced by a meal and infusions of bombesin and the synthetic CCK analog cerulein on plasma PP, and (2) the inhibition of PP secretion by the CCK-receptor antagonist CR-1409 during these three stimuli. The stimulation of PP secretion during bombesin (11.0 +/- 1.6 nM/hr) and after the meal (8.9 +/- 2.0 nM/hr) were significantly (P less than 0.05) greater than during infusion of the CCK analog cerulein (2.7 +/- 0.4 nM/hr). CR-1409 significantly inhibited the bombesin- and meal-stimulated PP secretion to 2.0 +/- 0.4 nM/hr (81%; P less than 0.05) and 3.1 +/- 1.2 nM/hr (47%; P less than 0.05), respectively, while the cerulein-stimulated PP release was almost abolished to 0.2 +/- 0.1 nM/hr (93%; P less than 0.05) by the drug. These findings point to an important role for CCK in the regulation of bombesin- and meal-stimulated PP secretion.
authors.affiliation: Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
authors.forename: A J
authors.initials: AJ
authors.lastname: de Jong
authors.forename: M V
authors.initials: MV
authors.lastname: Singer
authors.forename: W
authors.initials: W
authors.lastname: Niebel
authors.forename: L C
authors.initials: LC
authors.lastname: Rovati
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000818:Animals; D001839:Bombesin; D002108:Ceruletide; D002766:Cholecystokinin / Q000502:physiology*; D004285:Dogs; D005260:Female; D005502:Food; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D011377:Proglumide / Q000031:analogs & derivatives; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors
chemical_list: D011949:Receptors, Cholecystokinin; D010191:Pancreatic Polypeptide; D002108:Ceruletide; D002766:Cholecystokinin; D011377:Proglumide; C048181:lorglumide; D001839:Bombesin