[An experimental study on the pathogenesis of congenital hand malformation--with reference to local disturbance in the limb bud and congenital constriction band syndrome].
In order to study congenital constriction band syndrome, we performed local cauterization of the lower limb buds of embryos in fertilized white leghorn eggs between hour 0 on day 4 (day 4-0) and day 7-0 of incubation. Constriction bands, acrosyndactyly, and amputation of digits, malformations characteristic of this syndrome, were all induced by intervention after day 5-0, when digital ray formation was first observed, indicating that they all develop after ray formation. Histological examination showed that encapsulation and shedding of the lesion containing hematoma and necrotic tissue at the distal end of a digital ray led to digit amputation. When the cells encapsulating this lesion extend over another digital ray, moreover, the ray tips fuse, while the rest of the two digits involved remain discrete-resulting in acrosyndactyly.
Togawa
M
M
Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan.
D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004195:Disease Models, Animal; D006225:Hand / Q000196:embryology* / Q000473:pathology; D006228:Hand Deformities, Congenital / Q000196:embryology* / Q000209:etiology / Q000473:pathology