[Thiol-dependent protective systems in alimentary prevention of the toxic effect of carminomycin].
The state of the thiol-dependent systems i.e. concentration of the SH-groups, activity of glutathione reductase and glutathione-S-transferase, carminomycin antitumor and toxic effects was studied under conditions of tumor growth and carminomycin therapy with the use of prophylactic rations (PR) aimed at stimulating the cell thiol-dependent and antioxidant systems for decreasing the drug toxic action. It was shown that addition of sulfur-containing amino acids, selenium and vitamin E to the ration of healthy and tumor-bearing rats (Walker carcinosarcoma 256) induced a decrease in the level of the SH-groups in the liver just likely promoting efficient extrahepatic usage of glutathione. After administration of carminomycin a long with the PR use, the liver showed the thiol-preserving capacity evidenced by a decrease or complete elimination of the above effect of the ration. The use of PR resulted in a marked increase in the glutathione-S-transferase activity in cytosol and to a lesser extent in the liver microsomes. A regulating effect of the PR on the activity of glutathione reductase was observed: its inhibition in the healthy animals and stimulation after carminomycin administration in the heart of the healthy animals and the liver of the tumor-bearing animals.
Lenskaia
E G
EG
Tazhibaev
Sh S
ShS
Alekseeva
N R
NR
Monakhov
B V
BV
Karsybekova
N M
NM
Sisemalieva
Zh S
ZhS
Sarbaev
B T
BT
D000603:Amino Acids, Sulfur / Q000008:administration & dosage*; D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism; D002360:Carubicin / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D003630:Daunorubicin / Q000031:analogs & derivatives*; D005527:Food, Fortified; D008658:Inactivation, Metabolic / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000603:Amino Acids, Sulfur; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D002360:Carubicin; D020887:Selenious Acid; D024502:alpha-Tocopherol; D012643:Selenium; D024505:Tocopherols; D003630:Daunorubicin
Tiolzavisimye zashchitnye sistemy pri alimentarnoĭ profilaktike toksicheskogo deĭstviia karminomitsina.