[Modification by alpha-interferon of ethanol-induced changes in the level of opioid peptides in the rat striatum and hypophysis].
Content of Met-enkephalin in striatum and of beta-endorphin in rat hypophysis were estimated after administration of ethanol and alpha-interferon into the animals. Ethanol decreased Met-enkephalin content in striatum and of beta-endorphin in hypophysis. Preadministration of alpha-interferon into brain ventricles before ethanol administration led to an increase in concentration of Met-enkephalin, while content of beta-endorphin was unaltered. In peripheric administration alpha-interferon normalized content of beta-endorphin in adenohypophysis but did not affect the Met-enkephalin concentration. Effects of alpha-interferon on content of Met-enkephalin and beta-endorphin, related to dissimilar organization of the opiate systems in hypophysis and striatum tissues, are discussed.
Panchenko
L F
LF
Terebilina
N N
NN
Malinovskaia
V V
VV
Manakhova
L S
LS
Petrichenko
O B
OB
Balashov
A M
AM
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D004723:Endorphins / Q000032:analysis*; D004744:Enkephalin, Methionine / Q000032:analysis; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D010902:Pituitary Gland / Q000032:analysis*; D051381:Rats
D004723:Endorphins; D007370:Interferon Type I; D000431:Ethanol; D004744:Enkephalin, Methionine
Modifikatsiia pod vliianiem alpha-interferona vyzvannykh étanolom izmeneniĭ soderzhaniia opioidnykh peptidov v striatume i gipofize krys.