Tissue distribution and elimination of 14C-aminoglutethimide in the mouse.
Following oral administration of 14C-aminoglutethimide (Orimeten), male mice excreted 75% and female mice 59% of the administered dose during 24 h. After 72 h, elimination was essentially complete in male mice, whilst recovery from female mice was 74%. As assessed by quantitative assay and whole-body autoradiography, a wide distribution of radioactivity was found with high concentrations of radioactivity occurring only in the bile, gastro-intestinal tract and liver at early times. Residual (72 h) tissue levels of radioactivity were less than 1 microgram equiv. of 14C-aminoglutethimide/g tissue. Metabolite profiles in urine, tissues and faeces showed extensive metabolism of the drug in a pattern similar to that found in the rat.
Dalrymple
P D
PD
Welsh School of Pharmacy, U.W.C.C., Cardiff, UK.
Nicholls
P J
PJ
D000616:Aminoglutethimide / Q000493:pharmacokinetics*; D000818:Animals; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014018:Tissue Distribution
D000616:Aminoglutethimide