[Effect of ethanol on the levels of dopamine and its metabolites in the brain of rats with different degree of sensitivity to stress].
It was shown, that content of dopamine and its metabolites (DOPAC and HVA) are the same in two groups of rats with different time of immobilization in forced swimming test. One group of low active (LA) animals experienced the immobilization more than 300s, other high active (HA) rats for less than 120 s. Ethanol (2 g/kg per oris) increased the level of DA in the striatum and medial prefrontal cortex only in LA rats and besides, the concentration of dopamine after ethanol administration was higher in the n. accumbens of LA rats, than in that of HA rats. The authors suggest that differences in dopamine content between LA and HA rats are connected with different levels of voluntary alcohol consumption. The opportunity to use both groups of HA and LA rats for developing models of pathogenic heterogeneity of alcoholism is discussed.
Iukhananov
R Iu
RIu
Tennila
T M
TM
Miroshnichenko
I I
II
Kudrin
V S
VS
Raevskiĭ
K S
KS
Aĭraksinen
M M
MM
Maĭskiĭ
A I
AI
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000223:Adaptation, Psychological / Q000502:physiology; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D007101:Immersion; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism*; D013550:Swimming
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D000431:Ethanol; D004298:Dopamine; D006719:Homovanillic Acid
Vliianie étanola na uroven' dofamina i ego metabolitov v mozge krys s razlichnoĭ chuvstvitel'nost'iu k stressu.