title: [Dynamic CT under angiotensin II-induced hypertension--application for the differential diagnosis between benign and malignant solid ovarian tumors].
abstract: Dynamic CT was applied to 9 patients with solid ovarian tumors of an unknown nature after ultrasonography and tumor marker tests with CA125, TPA and IAP. Dynamic CT was performed under the condition of normotension and angiotensin II (AT II)-induced hypertension. The results obtained were as follows. 1. Intratumoral blood flow increased 25 percent in patients with malignant tumors, decreased 7 percent in tumors of low potential malignancy, and increased 6 percent in patients with benign tumors due to the pressor effect of AT II. 2. Changes in intratumoral blood flow were not uniform in various parts of a malignant tumor. 3. Differential diagnosis of malignant and benign tumors and tumors of low potential malignancy was possible by this method. 4. The results indicated that chemotherapy under AT II-induced hypertension would have a better effect on the treatment of malignant ovarian tumors.
authors.affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Higashijima
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Akizuki
authors.forename: N
authors.initials: N
authors.lastname: Kishi
authors.forename: M
authors.initials: M
authors.lastname: Yakushiji
mesh_terms: D000328:Adult; D000804:Angiotensin II; D001794:Blood Pressure / Q000187:drug effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000804:Angiotensin II