Enzyme polymorphism and clinical variability of diseases: study of acid phosphatase locus 1 (ACP1) in obese subjects.
The ACP1*A allele of erythrocyte acid phosphatase (ACP1) has a lower enzymatic activity when compared to other ACP1 alleles and is associated with maximal rate of body growth during intrauterine life. In three different samples of obese subjects (total number = 218). ACP1*A was associated with extreme body mass deviations. No difference in ACP1 allele distribution was observed between obese and nonobese subjects. These data suggest that a genetically determined variability of ACP1 influences the degree of obesity, but only when obesity itself has been triggered by some other factors.
Bottini
E
E
Chair of Human Development, 2d University of Rome, School of Medicine, Italy.
Lucarini
N
N
Gerlini
G
G
Finocchi
G
G
Sciré
G
G
Gloria-Bottini
F
F
D000135:Acid Phosphatase / Q000235:genetics*; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009765:Obesity / Q000201:enzymology / Q000235:genetics* / Q000473:pathology
D000135:Acid Phosphatase