[Severe neutropenia following cytostatic drug therapy--clinical symptoms, follow-up and prognosis in 26 patients of a district hospital].
The clinical courses of 26 patients with severe neutropenia after application of cytostatic agents are demonstrated. The symptomatology reaches from complete freedom of complaints to severe and most severe clinical appearances. In all 7 asymptomatic patients a complete remission of the changes of the blood picture occurred. Patients with lacking or partial remission of the blood picture after severe neutropenia induced by cytostatic agents have in general a bad prognosis quoad vitam. Infections are the most important complication of a severe neutropenia. Conclusions for the clinical practice concerning the prophylaxis and the early recognition of severe neutropenias as well as of neutropenic complications are derived. Irreversible lesions of the bone marrow by cytostatic agents are notifiable unwished effects of drugs.
Radke
E U
EU
Inneren Abteilung, Kreiskrankenhauses Sebnitz.
Papke
J
J
D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced*; D009894:Opportunistic Infections / Q000139:chemically induced; D012189:Retrospective Studies; D012307:Risk Factors
D000970:Antineoplastic Agents
Schwere Neutropenie nach Zytostatikatherapie--klinische Symptomatik, Verlauf und Prognose bei 26 Patienten eines Kreiskrankenhauses.