[The effect of L-carnitine on the energy metabolism of isolated rat heart perfused by Langendorff's method using 31P-NMR spectroscopy].
31P-NMR spectroscopy is a method for continuous, noninvasive determination of high-energy phosphates in the intact organ. On the isolated Langendorff perfused rat heart the effect of L-carnitine on concentration of cytosolic ATP and phosphocreatine was studied under influence of a single or repeated periods of 20 min ischemia. On reperfusion the carnitine-treated hearts showed higher CP/Pi values and an increase of the energy index (CP + ATP)/(C) + ATP + Pi) then did control hearts. An improved ischemia tolerance was demonstrated.
Löster
H
H
Institut für Pathologische Biochemie, Bereichs Medizin, Karl-Marx-Universität Leipzig.
Gründer
W
W
Keller
T
T
Seim
H
H
Grommisch
J
J
Müller
F
F
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015425:Myocardial Reperfusion; D010725:Phosphocreatine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D002331:Carnitine
Untersuchungen zum Einfluss von L-Carnitin auf den Energiestoffwechsel des isolierten, nach Langendorff perfundierten Rattenherzens mittels 31P-NMR-Spektroskopie.