title: [The protective properties of different Legionella antigens in experimental Legionella infection].
abstract: The protective properties of Legionella antigenic preparations were studied on guinea pigs with experimental Legionella infection. Preliminary immunization of guinea pigs with serotypic antigen, cytolysin, as well as live or formalin-treated Legionella cells, did not protect the animals from the subsequent aerogenic infection with 10(5) colony-forming units of virulent L. pneumophila. Immunization with the main outer membrane protein ensured the survival of 70% of the animals and inhibited the proliferation of the infective agent in the lungs of guinea pigs subjected to aerogenic infection with 10(5) colony-forming units of virulent L. pneumophila. The data obtained in this study indicate that the main outer membrane protein of L. pneumophila is capable of stimulating protective immunity.
authors.forename: I S
authors.initials: IS
authors.lastname: Tartakovskiĭ
authors.forename: I K
authors.initials: IK
authors.lastname: Zubashev
authors.forename: V F
authors.initials: VF
authors.lastname: Koniukhov
authors.forename: V V
authors.initials: VV
authors.lastname: Petrosov
authors.forename: B V
authors.initials: BV
authors.lastname: Eruslanov
authors.forename: L V
authors.initials: LV
authors.lastname: Nebozhina
authors.forename: A V
authors.initials: AV
authors.lastname: Rodionov
authors.forename: B A
authors.initials: BA
authors.lastname: Dmitriev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Suchkov
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
mesh_terms: D000336:Aerosols; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D007875:Legionella / Q000276:immunology* / Q000472:pathogenicity; D007877:Legionnaires' Disease / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D008168:Lung / Q000382:microbiology; D012692:Serial Passage; D013997:Time Factors; D014774:Virulence
chemical_list: D000336:Aerosols; D000942:Antigens, Bacterial
vernacular_title: Izuchenie protektivnykh svoĭstv razlichnykh antigenov legionell pri éksperimental'noĭ legionelleznoĭ infektsii.