Excretion of tolbutamide metabolites in young and old subjects.
Tolbutamide (1 g/70 kg) was administered as a single intravenous dose to 31 healthy, non-smoking, drug-free males between 23 and 87 years old and the total amounts of hydroxy and carboxytolbutamide excreted in 24 h were measured. There was a significant decrease in the urinary recovery of both metabolites with age. The reason for these findings is not known at the present time and may be associated with the decrease in creatinine clearance observed in these subjects or other changes in the pharmacokinetics of tolbutamide which are currently being investigated.
Miller
A K
AK
Department of Pharmaceutics, College of Pharmacy and Pharmacal Sciences, Howard University, Washington, D.C. 20059.
Adir
J
J
Vestal
R E
RE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014044:Tolbutamide / Q000031:analogs & derivatives / Q000652:urine*; D000096926:Benzenesulfonamides
D014044:Tolbutamide; C006913:carboxytolbutamide; C031014:hydroxymethyltolbutamide; D000096926:Benzenesulfonamides