[Studies of the dependence of alkoxycyanodiphenyl toxicity on structure with the aim of health-related group standardization].
The article presents results of toxicity and hazard effects studies of alcoxicyandiphenyl CnH2n+ 1OC12H8CN with n = 1-8, octilcyandiphenyl and octildiphenyl. Toxicity parameters were established in animal tests and on isolated mitochondria, and inhibiting concentrations were calculated. Correlation was established between the alcoxicyandiphenyl detainment in high-performance liquid chromatography and the inhibition rate constant. The allowable and hazard levels are also specified.
Kurliandskiĭ
B A
BA
Balabanova
E L
EL
Kliachkina
A M
AM
Braude
E V
EV
Pervukhina
I V
IV
D000818:Animals; D001713:Biphenyl Compounds / Q000032:analysis / Q000592:standards / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects; D009570:Nitriles / Q000032:analysis / Q000592:standards / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
D001713:Biphenyl Compounds; D009570:Nitriles
Izuchenie zavisimosti toksichnosti alkoksitsiandifenilov ot ikh struktury s tsel'iu gruppovogo gigienicheskogo normirovaniia.