title: Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin.
abstract: Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a relation between the pathogenesis of PD and the function of cytochrome P450 subsystems.
authors.affiliation: Department of Neurology, University Hospital of Leiden, The Netherlands.
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: E A
authors.initials: EA
authors.lastname: Peeters
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
authors.forename: P
authors.initials: P
authors.lastname: Vermey
authors.forename: F A
authors.initials: FA
authors.lastname: de Wolff
authors.forename: O J
authors.initials: OJ
authors.lastname: Buruma
mesh_terms: D000368:Aged; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism*
chemical_list: D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System