Serum sickness-like syndrome associated with minocycline therapy.
A 19 year-old youth was taking oral minocycline and after 8 days he presented all four cardinal symptoms of serum sickness (urticaria, fever, lymphadenopathy and joint symptoms). C3, C4 and CH50 evolution imitate experimental serum sickness complement evolution. We exclude other causes of this syndrome. Although other hypersensitivity reactions have occurred with minocycline usage, to our knowledge serum sickness-like syndrome has not been previously reported with this drug.
Puyana
J
J
Department of Allergy, Ramon y Cajal Hospital, Madrid, Spain.
Ureña
V
V
Quirce
S
S
Fernandez-Rivas
M
M
Cuevas
M
M
Fraj
J
J
D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012713:Serum Sickness / Q000139:chemically induced* / Q000276:immunology; D013577:Syndrome; D013754:Tetracyclines / Q000009:adverse effects*; D013997:Time Factors
D013754:Tetracyclines; D008911:Minocycline