title: Differential diagnosis of fibro-osseous jaw lesions. A histological investigation on 30 cases.
abstract: A series of 30 fibro-osseous jaw lesions was evaluated for histological parameters that enable appropriate diagnostic classification. Special emphasis was laid upon the histomorphology of the lesion-jawbone interface, blending of lesional bone with adjacent jawbone being employed as the decisive factor in distinguishing between fibrous dysplasia and other fibro-osseous jaw lesions. Using this feature as a discriminative tool, other histological aspects that were useful in differential diagnosis could be identified. Fibrous dysplasia (n = 11) shows a rather uniform appearance with a constant ratio bone: fibrous tissue throughout the entire lesion; acellular mineralized particles are virtually absent. Juvenile ossifying fibroma (n = 3) is characterized by a highly cellular fibroblastic stroma and garland-like strands of cellular osteoid. Ossifying fibroma (n = 12) shows a high variability in stromal cellularity and types of mineralized material. Localized periapical fibro-osseous cemental lesions (n = 4) are histologically almost similar to ossifying fibroma although more heavily mineralized. It is concluded that there is full agreement between histology and radiology in indicating whether a fibro-osseous jaw lesion is demarcated or blends into its surroundings. Moreover, an appropriate diagnosis can be reliably made on histological grounds.
authors.affiliation: Pathology Instítute, University of Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Slootweg
authors.forename: H
authors.initials: H
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003094:Collagen; D003937:Diagnosis, Differential; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005350:Fibroma / Q000000981:diagnostic imaging / Q000473:pathology; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007568:Jaw / Q000000981:diagnostic imaging / Q000473:pathology; D007571:Jaw Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010016:Osteoma / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography
chemical_list: D003094:Collagen