[Distribution of calcium and magnesium in soft tissues, especially in the central nervous system, and bone of rats fed with low calcium-magnesium with or without aluminum loading diets].
Current epidemiological investigations in the Western Pacific area have suggested that the environmental factors contribute to the pathogenetic process of amyotrophic lateral sclerosis (ALS). The condition of unbalanced minerals found in soil and drinking water of ALS foci with low content of Ca and Mg plus high content of Al was experimentally mimicked in this study using rats. In the groups fed with low calcium diet, low Ca-Mg diet and low Ca-Mg plus high Al diet, serum calcium levels were lower than those in the group fed with standard diet. Also serum Mg levels were lower in the groups fed with low Ca-Mg diet and low Ca-Mg plus high Al diet than in the group fed with standard diet and low Ca diet. However, there was no significant difference in Mg content of the central nervous system (CNS) tissues of groups with unbalanced and standard diets except for that in spinal cord of rats fed with low Ca-Mg plus high Al diet, determined by inductively coupled plasma emission spectrometry. On the other hand, Ca content of CNS showed higher values in the unbalanced diet groups, especially in spinal cord of the low Ca-Mg plus high Al diet group, than those in the standard diet group. And Ca content in heart, liver, kidney and abdominal aorta of rats fed with both low Ca-Mg diet and low Ca-Mg plus high Al diet increased that those of standard and low Ca diet groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Yasui
M
M
Division of Neurological Diseases, Wakayama Medical College, Japan.
Yano
I
I
Yase
Y
Y
Ota
K
K
D000535:Aluminum / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D005526:Food, Formulated; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014781:Viscera / Q000187:drug effects / Q000378:metabolism*
D000535:Aluminum; D008274:Magnesium; D002118:Calcium