title: [Treatment of defects of the long bones using distraction osteogenesis (Ilizarov) and intramedullary nailing. Theoretic principles, animal experiments, clinical relevance].
abstract: For large shaft defects of tibia and femur, distraction-compression osteosynthesis (Ilizarov) provides an ideal autologous bone graft. Combination of this with an intramedullary interlocking nail instead of an external fixator could improve patient comfort, because transport with a small external device takes only one-third of the total fixation period. Using 21 adult female sheep we created standardized tibia shaft defects 20 mm (medium size) and 45 mm (large size) in length. The tibiae were stabilized with non-reamed intramedullary interlocking nails. Following corticotomy by chisel, segments were transported using subcutaneous traction wires with a screw as a fulcrum to maintain stationary skin exit points without soft tissue problems. The external traction devices were removed after 12 or 16 weeks. Animals were sacrificed after 12 or 24 weeks with medium-size defects, and after 16 or 32 weeks with large defects. We evaluated the results clinically, by standardized weekly X-rays and, after sacrifice, by quantitative computed tomography (QCT). No animals had to be excluded from the study. Despite primary destruction of the intramedullary circulation all distraction gaps were spanned with bone. X-Rays showed typical signs of good quality of distraction bone regeneration (narrow radiolucent zone in the middle of the regenerate, longitudinal structure), continuous calcification, and cortex formation. QCT cross sections showed completely circular bone regeneration with small and large defects. Bone regeneration was faster on the dorsal side, where more bone was formed than ventrally. Small defects can remain ventrally in the regenerate; these close secondarily.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Chirurgische Klinik Innenstadt, Ludwig-Maximilians-Universität München.
authors.forename: U
authors.initials: U
authors.lastname: Brunner
authors.forename: S
authors.initials: S
authors.lastname: Kessler
authors.forename: J
authors.initials: J
authors.lastname: Cordey
authors.forename: B
authors.initials: B
authors.lastname: Rahn
authors.forename: L
authors.initials: L
authors.lastname: Schweiberer
authors.forename: S M
authors.initials: SM
authors.lastname: Perren
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D005260:Female; D005594:Fracture Fixation, Intramedullary; D009984:Orthopedic Fixation Devices; D012756:Sheep; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014143:Traction
vernacular_title: Defektbehandlung langer Röhrenknochen durch Distraktionsosteogenese (Ilizarov) und Marknagelung. Theoretische Grundlagen, tierexperimentelle Ergebnisse, klinische Relevanz.