title: Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow.
abstract: We examined the ability of individual regions of the canine left ventricle to increase blood flow relative to baseline rates of perfusion. Regional coronary flow was measured by injecting radioactive microspheres over 90 seconds in seven anesthetized mongrel dogs. Preliminary experiments demonstrated a correlation between the regional distributions of blood flow during asphyxia and pharmacological vasodilatation with adenosine (mean r = 0.75; 192 regions in each of two dogs), both of which resulted in increased coronary flow. Subsequent experiments, during which coronary perfusion pressure was held constant at 80 mm Hg, examined the pattern of blood flow in 384 regions (mean weight, 106 mg) of the left ventricular free wall during resting flow and during maximal coronary flow effected by intracoronary adenosine infusion. We found that resting and maximal flow patterns were completely uncorrelated to each other in a given dog (mean r = 0.06, p = NS; n = 3 dogs). Furthermore, regional coronary reserve, defined as the ratio of maximal to resting flow, ranged from 1.75 (i.e., resting flow was 57% of maximum) to 21.9 (resting flow was 4.5% of maximum). Thus, coronary reserve is spatially heterogeneous and determined by two distinct perfusion patterns: the resting (control) pattern and the maximal perfusion pattern. Normal hearts, therefore, contain small regions that may be relatively more vulnerable to ischemia. This may explain the patchy nature of infarction with hypoxia and at reduced perfusion pressures as well as the difficulty of using global parameters to predict regional ischemia. Despite the wide dispersion of coronary reserve, we found, by autocorrelation analysis, that reserve in neighboring regions (even when separated by a distance of several tissue samples) was significantly correlated. This also applied to patterns of resting myocardial flow. Thus, both resting coronary blood flow and reserve appear to be locally continuous and may define functional zones of vascular control and vulnerability, respectively.
authors.affiliation: Cardiovascular Research Institute, University of California, San Francisco 94143.
authors.forename: R E
authors.initials: RE
authors.lastname: Austin
authors.forename: G S
authors.initials: GS
authors.lastname: Aldea
authors.forename: D L
authors.initials: DL
authors.lastname: Coggins
authors.forename: A E
authors.initials: AE
authors.lastname: Flynn
authors.forename: J I
authors.initials: JI
authors.lastname: Hoffman
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001237:Asphyxia / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D014644:Genetic Variation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008863:Microspheres; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D010477:Perfusion; D012016:Reference Values; D013997:Time Factors; D016276:Ventricular Function
chemical_list: D000241:Adenosine