Stressor-like effects of FG-7142 on medial prefrontal cortex self-stimulation.
The effects of uncontrollable stress and the anxiogenic beta-carboline FG-7142 were compared on rats bar-pressing for electrical stimulation of the medial prefrontal cortex (MPC). One minute of restraint stress produced an immediate 20% increase in response rates. A significant facilitation was also evident 24 and 48 h later. Similarly, FG-7142 (10 mg/kg) produced an immediate 20% elevation of self-stimulation rates and a significant facilitation 24 and 48 h following administration. Lower (3 mg/kg) and higher (20 mg/kg) doses of FG-7142 caused immediate decreases in MPC self-stimulation and no significant long-term effects. These results agree with previous findings that FG-7142, administered at certain doses, may mimic the effects of exposure to uncontrollable stress.
McGregor
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Department of Psychology, University of Sydney, N.S.W., Australia.
Atrens
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D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000503:physiopathology; D002243:Carbolines / Q000494:pharmacology*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012653:Self Stimulation / Q000187:drug effects*; D013315:Stress, Psychological / Q000503:physiopathology*
D002243:Carbolines; C035874:FG 7142