Cyclosporine in vitro reduces endothelium-dependent relaxation to acetylcholine but does not affect relaxation to nitrovasodilators.
Dinh Xuan
A T
AT
Respiratory Physiology Department, Papworth Hospital, Cambridge, UK.
Fan
T P
TP
Higenbottam
T W
TW
Wallwork
J
J
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000502:physiology*; D003524:Cyclosporins / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005292:Ferricyanides / Q000494:pharmacology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation / Q000187:drug effects*
D003524:Cyclosporins; D005292:Ferricyanides; D009599:Nitroprusside; D000109:Acetylcholine; D007213:Indomethacin