title: Plasma chloride and alkalaemia in pyloric stenosis.
abstract: Fifty infants with infantile hypertrophic pyloric stenosis were studied prospectively to evaluate the reliability of plasma chloride estimation in the assessment of the acid-base status on admission and during correction of alkalaemia. Four cases were subsequently excluded because of a breach of the study protocol, leaving 46 cases in the study. Seventeen (37 per cent) were normoacidaemic on admission; 13 had plasma chloride concentrations of greater than or equal to 106 mmol/l and four had chloride concentrations of 100-105 mmol/l on admission. Twenty-nine (63 per cent) were alkalaemic on admission; six cases had chloride concentrations of 100-105 mmol/l and 23 cases had concentrations of less than 100 mmol/l. Of those 29 cases requiring correction of alkalaemia, normoacidaemia was achieved at a plasma chloride concentration of greater than or equal to 106 mmol/l in 21 cases (72 per cent) and at a concentration of 100-105 mmol/l in eight cases (28 per cent). Plasma chloride is a reliable parameter in the assessment and correction of alkalaemia in infantile hypertrophic pyloric stenosis provided that a concentration of at least 106 mmol/l is the goal.
authors.affiliation: Department of Paediatric Surgery, Birmingham Children's Hospital, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Goh
authors.forename: S K
authors.initials: SK
authors.lastname: Hall
authors.forename: P
authors.initials: P
authors.lastname: Gornall
authors.forename: R G
authors.initials: RG
authors.lastname: Buick
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: J J
authors.initials: JJ
authors.lastname: Corkery
mesh_terms: D000136:Acid-Base Equilibrium; D000471:Alkalosis / Q000097:blood*; D002712:Chlorides / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011189:Potassium Chloride / Q000097:blood; D011707:Pyloric Stenosis / Q000097:blood*; D012965:Sodium Chloride / Q000097:blood
chemical_list: D002712:Chlorides; D012965:Sodium Chloride; D011189:Potassium Chloride