title: ACP and Surgicel in bone hemostasis. A comparative experimental and histologic study.
abstract: The search for a biodegradable material which may prevent or stop bleeding in bone tissue and ensure healing is of continuous interest. ACP, an absorbable collagen paste, is a new hemostatic agent. The present study was devised to compare ACP with another commonly used hemostatic agent, Surgicel, in order to determine the tissue response during bone healing. The materials were implanted in the mandibular bone of New Zealand white rabbits. The observation times were 1, 2, 4 and 8 weeks. The result showed that the healing was uneventful for both the hemostatic agents even though healing was slightly retarded compared to natural healing. Both the hemostatic agents were completely resorbed within 4-8 weeks and also the bone healing was completed after this observation period.
authors.affiliation: Department of Oral Surgery, School of Dentistry, Karolinska Institutet, Stockholm, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Mattsson
authors.forename: G
authors.initials: G
authors.lastname: Anneroth
authors.forename: P A
authors.initials: PA
authors.lastname: Köndell
authors.forename: A
authors.initials: A
authors.lastname: Nordenram
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D001861:Bone Regeneration / Q000187:drug effects*; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use; D008334:Mandible / Q000601:surgery; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D006490:Hemostatics; C013695:Surgicel; D002482:Cellulose; D003094:Collagen