[Photosensitized formation of singlet oxygen in water solutions of covalent porphyrin-antibody conjugates].
The effective photogeneration of singlet molecular oxygen (1O2) by porphyrins (coproporphyrin I; 2,4-bi (alpha-methoxyethyl) deuteroporphyrin IX and cyclopanten-coproporphyrin I) conjugated with antibodies (mouse monoclonal IgG and IgM and human gamma-globulin) have been observed with the direct luminescence method of 1O2 detection. Absolute quantum yields of 1O2 formation by the conjugates have been determined. The data suggest that porphyrin-antibody conjugates are promising for the use as drugs in photodynamic tumor treatment.
Egorov
S Iu
SIu
Krasnovskiĭ
A A
AA
Pankovskiĭ
D B
DB
Ponomarev
G V
GV
Savitskiĭ
A P
AP
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology* / Q000627:therapeutic use; D053685:Laser Therapy; D051379:Mice; D010100:Oxygen; D010777:Photochemistry; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology* / Q000627:therapeutic use; D026082:Singlet Oxygen; D012996:Solutions; D014867:Water
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D011166:Porphyrins; D012996:Solutions; D014867:Water; D026082:Singlet Oxygen; D010100:Oxygen
Fotosensibilizirovannoe obrazovanie singletnogo kisloroda v vodnykh rastvorakh kovalenthykh kon''iugatov porfirinov s antitelami.