The effect of molecular structure in a series of merocyanines on the in vitro cytotoxicity for adenocarcinoma cells.
Preliminary results have shown that merocyanines were cytotoxic for human adenocarcinoma cells in vitro. We report the synthesis of a series of new merocyanines and the structure-effect relationship as cytotoxic agents on human adenocarcinoma cells in vitro. Some of these new derivatives were found very cytotoxic for tumor cells in vitro, whereas their systemic toxicity in vivo was very low.
Laliberté
S
S
Department of Chemistry-Biology, UQTR, Trois-Rivières, Québec, Canada.
Gruda
I
I
Pagé
M
M
Grenier
F
F
Pépin
A
A
Noël
C
C
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D011744:Pyrimidinones / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D011744:Pyrimidinones; C003954:merocyanine dye