title: Fc receptor gene translocation in a t(1;19) pre-B ALL cell line.
abstract: We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene.
authors.affiliation: Department of Cytogenetics and Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
authors.forename: L M
authors.initials: LM
authors.lastname: Webber
authors.forename: O M
authors.initials: OM
authors.lastname: Garson
authors.forename: B
authors.initials: B
authors.lastname: Tate
authors.forename: I F
authors.initials: IF
authors.lastname: McKenzie
authors.forename: P M
authors.initials: PM
authors.lastname: Hogarth
mesh_terms: D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D009693:Nucleic Acid Hybridization; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011961:Receptors, Fc / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D011961:Receptors, Fc