[The effect of injectable leukinferon on the immune reactivity of patients with steroid-dependent bronchial asthma].
The authors provide the results of the treatment with leukinferon for injections of 25 patients with steroid-dependent bronchial asthma. It is the authors' belief that leukinferon for injections may be recommended for introduction into multimodality schedules of the treatment of patients with the above-indicated pathology. The drug is tolerated well, without any phenomena of sensitization, when administered by inhalation in the form of aqueous aerosol in a dose of 10,000 IU/day. As a result of 6 to 8 injections, immunoreactivity showed a positive time-course of changes, the patients' clinical status improved, and the maintenance doses of glucocorticosteroids could be noticeably reduced.
Marinin
V F
VF
Andriukin
A A
AA
Kuznetsov
V P
VP
Nastiukova
E G
EG
Dudkina
L N
LN
Niaĭkina
N Iu
NIu
Beliaev
D L
DL
D000280:Administration, Inhalation; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D016207:Cytokines; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007370:Interferon Type I / Q000008:administration & dosage*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D016207:Cytokines; D004338:Drug Combinations; D005938:Glucocorticoids; D007370:Interferon Type I; C062252:leukinferon; D007073:Immunoglobulin E
O vliianii leĭkinferona dlia in''ektsiĭ na immunoreaktivnost' bol'nykh steroidozavisimoĭ bronkhial'noĭ astmoĭ.