[Treatment of adult type atopic dermatitis (AD) with bacterial vaccine prepared from individual cases (II)--The mechanism].
Sixty eight cases with severe adult type AD treated by bacterial vaccine were classified into 2 subgroups, effective and ineffective cases. And the differences of these 2 subgroups were examined by various laboratory data. In effective groups, specific IgG antibody level against bacteria increased to correlate to the clinical course. In contrast, ineffective groups were not changed the antibody level. There were no significant differences between these 2 subgroups concerning results of specific IgE antibody level against bacteria. Decrease of CD4/CD8 ratio was more prominent in effective groups than ineffective groups after treated for 6 months. It is known that bacteria and bacterial products (peptidoglycan and endotoxin etc) cause release of histamine. Our results support that the elevation of specific IgG antibody against bacteria and enhanced cell mediated immunity are decreased the numbers of bacteria on the skin surface and improved irritable skin. These effects may be inhibit histamine release induced by bacteria, so therefore we suggest that general skin condition and pruritus with AD will be improved by the treatment.
Mukai
H
H
Department of Dermatology, Kitasato University School of Medicine.
Nishioka
K
K
Noguchi
T
T
Fujimoto
S
S
Nishiyama
S
S
Akiyama
S
S
D000328:Adult; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013210:Staphylococcus / Q000276:immunology
D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D007073:Immunoglobulin E