The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats.
Groups of isogenous Brown-Norway rats received heterotopic heart transplants from (Brown-Norway/Wistar Furth) x F1 hybrid rats. Methylprednisolone was administered IV in a daily dose of 5-40 mg/kg, using a dose interval of 24, 12, or 0 h (continuous infusion). Continuous infusion proved to be superior when small daily doses were used and then caused a more than threefold increase in graft survival. High daily doses created a substantial mortality with all dose intervals. Moreover, the equipment used for continuous drug administrations was unreliable beyond 4 weeks of infusion.
Husberg
B S
BS
Transplantation Services, Baylor University Medical Center, Dallas, TX 75246.
Konrad
P I
PI
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation / Q000276:immunology*; D007165:Immunosuppression Therapy; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D051381:Rats; D011914:Rats, Inbred BN; D014185:Transplantation, Isogeneic
D008775:Methylprednisolone