title: Quantification of the relation between electrophysiologic and morphologic changes in experimental endolymphatic hydrops.
abstract: The degree of hydrops in guinea pig ears that had undergone unilateral endolymphatic sac and duct obliteration was quantified. For 15 guinea pigs from a prior study, the correlation between the degree of hydrops and several electrophysiologic measures of the functional state of the cochlea was determined. A significant correlation between the degree of hydrops and a reduction in the low-frequency cochlear microphonic evoked by a 29-Hz tone was found. No correlation was found between the degree of hydrops and the magnitude of the summating potential evoked by 8-kHz probes. A weak correlation was found between the degree of hydrops and a reduction in the compound action potential evoked by 2-kHz probes. Possible differences in the way the endolymphatic duct obliteration exerts its effect on the different cochlear potentials are discussed.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands.
authors.forename: S F
authors.initials: SF
authors.lastname: Klis
authors.forename: J
authors.initials: J
authors.lastname: Buijs
authors.forename: G F
authors.initials: GF
authors.lastname: Smoorenburg
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004487:Edema / Q000473:pathology / Q000503:physiopathology*; D004594:Electrophysiology; D004711:Endolymphatic Duct; D005069:Evaluation Studies as Topic; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006168:Guinea Pigs; D008433:Mathematics; D015837:Vestibular Diseases / Q000473:pathology / Q000503:physiopathology*; D014722:Vestibule, Labyrinth