[Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].
The biocompatibility and pharmacokinetics of hydroxypropylmethylcellulose (HPMC) 2% (Adatocel) and Tylose 2% (MH 1000) were investigated. A modified anterior chamber implantation test on the rabbit eye is suitable for testing both the biocompatibility and the pharmacokinetics of visco-surgical substances. Both substances were well tolerated. From the fourth day onward, HPMC was no longer detectable in the anterior chamber by infrared spectroscopy.
Ehrich
W
W
Augenklinik der Universität des Saarlandes, Homburg/Saar.
Höh
H
H
Kreiner
C F
CF
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects / Q000378:metabolism*; D001672:Biocompatible Materials; D005260:Female; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D001672:Biocompatible Materials; D065347:Hypromellose Derivatives; D008747:Methylcellulose
Biologische Verträglichkeit und Pharmakokinetik von Hydroxypropylmethylcellulose (HPMC) in der Vorderkammer des Kaninchenauges.