Antibody transport and internalization into tumours.
Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
Matzku
S
S
Institute of Radiology and Pathophysiology, German Cancer Research Center, Heidelberg.
Moldenhauer
G
G
Kalthoff
H
H
Canevari
S
S
Colnaghi
M
M
Schuhmacher
J
J
Bihl
H
H
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism*; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes