[Biopharmaceutic studies of a bioerodible nystatin unit].
The release of nystatin from monolithic bioerodible system with pectin was studied. The process of both system degradation and drug release was expressed with an equation of Hixon and Crowell. It was established that an increasing thickness of the system as well as an increase of drug concentration decreased the rate of erosion and the release of the active principle. Both the concentration of the plastificator and the temperature of drying the system in the range of investigation did not change these processes.
Krusteva
S
S
Institut für Pharmakologie und Pharmazie, Medizinische Akademie, Sofia, VR Bulgarien.
Lambov
N
N
Velinov
G
G
D001702:Biopharmaceutics; D003692:Delayed-Action Preparations; D009761:Nystatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011108:Polymers
D003692:Delayed-Action Preparations; D011108:Polymers; D009761:Nystatin
Biopharmazeutische Untersuchungen einer bioerodierbaren Nystatineinheit.