Serum interleukin 2-receptor levels in uveitis.
This study reports on serum interleukin 2-receptor (IL-2R) levels in uveitis patients. IL-2R is the mediator protein of interleukin 2 (IL-2), a mitogenetic cytokine of primarily immune cell interaction. Stimulated T-cells readily express IL-2R on their cell surface and release a soluble form into serum. The measurement of IL-2R serum levels was performed using a monoclonal antibody based ELISA with age and sex matched healthy blood donors serving as the control group. The increase of IL-2R serum levels in patients affected by heterochromic cyclitis Fuchs (HCF) and a small group of children with chronic anterior uveitis affected by juvenile rheumatoid arthritis (JRA) was statistically highly significant, when compared to the control group (n = 84, alpha = 0.01). Serum levels of patients with intermediate uveitis (IU), patients with HLA-B27 positive acute anterior uveitis (AAU) and patients with HLA-B27 negative AAU did not differ significantly from the controls.
Arocker-Mettinger
E
E
2nd Department of Ophthalmology, University of Vienna, Austria.
Asenbauer
T
T
Ulbrich
S
S
Grabner
G
G
D000704:Analysis of Variance; D000911:Antibodies, Monoclonal; D001171:Arthritis, Juvenile / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*; D014605:Uveitis / Q000097:blood*; D014606:Uveitis, Anterior / Q000097:blood; D015867:Uveitis, Intermediate / Q000097:blood
D000911:Antibodies, Monoclonal; D015796:HLA-B27 Antigen; D015375:Receptors, Interleukin-2