title: Quantitative SPECT by attenuation correction of the projection set using transmission data: evaluation of a method.
abstract: A method for measuring attenuation coefficients in single-photon emission tomography (SPECT) is described and evaluated, together with a method for attenuation correction using these measured attenuation coefficients. Build-up, caused by scattered photons, is corrected for by a simple substitution in the algorithms. Transmission studies are performed with a 99mTc- or 57Co flood source, and emission phantom studies with 99mTc line sources. The method is evaluated with variable but well-defined phantoms. The result is accurate attenuation coefficients for different densities, dimensions and geometries, and an accuracy of corrected emission activities of better than +/- 10% in most cases. The present limitations of the method for attenuation correction are discussed.
authors.affiliation: Department of Clinical Physiology, University of Lund, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Almquist
authors.forename: J
authors.initials: J
authors.lastname: Palmer
authors.forename: M
authors.initials: M
authors.lastname: Ljungberg
authors.forename: P
authors.initials: P
authors.lastname: Wollmer
authors.forename: S E
authors.initials: SE
authors.lastname: Strand
authors.forename: B
authors.initials: B
authors.lastname: Jonson
mesh_terms: D000465:Algorithms; D003037:Cobalt Radioisotopes; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008961:Models, Structural; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D003037:Cobalt Radioisotopes; D013667:Technetium