Dietary beta-carotene and 13-cis-retinoic acid are not effective in preventing some features of UVB-induced dermal damage in hairless mice.
Albino hairless mice were fed diets containing 10 g/kg feed of beta-carotene and 200 mg/kg feed of 13-cis retinoic acid to assess the ability of these molecules to prevent UVB-induced dermal damage. Diets were administered for 12 weeks prior to UVB exposure and were continued throughout the 20 week irradiation period. The UVB source was a bank of FS-20 sunlamps (280-400 nm: peak 313 nm). Exposures were thrice weekly at 0.1 J/cm2 per exposure for the first 10 weeks and 0.2 J/cm2 per exposure for the second 10 weeks. Histologic evaluation of skin biopsies revealed no difference, between animals fed active or placebo diets, in UVB-induced elastosis, collagen changes or amounts of glycosaminoglycans and proteoglycans of the ground substance.
Kligman
L H
LH
University of Pennsylvania, School of Medicine, Department of Dermatology, Philadelphia 19104-6142.
Mathews-Roth
M M
MM
D000818:Animals; D002338:Carotenoids / Q000008:administration & dosage / Q000627:therapeutic use*; D004032:Diet; D051379:Mice; D008812:Mice, Hairless; D011832:Radiation Injuries / Q000517:prevention & control*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D014466:Ultraviolet Rays; D019207:beta Carotene
D019207:beta Carotene; D002338:Carotenoids; D014212:Tretinoin