title: Bile acid profile as early indicator of allograft function during orthotopic liver transplantation.
abstract: Orthotopic liver transplantation was performed in 20 pigs. Serum total bile acids (STBA) were determined and their profile compared with standard early function parameters: total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid. In phase I, the STBA level was 32.89 +/- 1.29 mumol/l. In phase II, STBA accumulated to 84.46 +/- 15.25 mumol/l (p less than 0.01), followed by hepatic clearance in phase III (63.61 +/- 9.71 mumol/1; NS). Between phase III and 6- and 12-hour samples, STBA decreased progressively, reaching values of 33.63 +/- 7.05 mumol/l at 24 h. AST was elevated in phases I, II, III, and at 6, 12 and 24 h (p less than 0.001), as was ALT (but with insignificant differences). Thus, STBA and their profile appear to be earlier and more specific indicators of early graft function than conventional parameters.
authors.affiliation: Departamento de Cirugía, Clínica Puerta de Hierro, Madrid, España.
authors.forename: F J
authors.initials: FJ
authors.lastname: Herrera
authors.forename: R
authors.initials: R
authors.lastname: Codoceo
authors.forename: J
authors.initials: J
authors.lastname: Cienfuegos
authors.forename: F
authors.initials: F
authors.lastname: Pardo
authors.forename: N P
authors.initials: NP
authors.lastname: Mora
authors.forename: F
authors.initials: F
authors.lastname: Pereira
authors.forename: J L
authors.initials: JL
authors.lastname: Castillo-Olivares
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests; D016031:Liver Transplantation; D015424:Reperfusion; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D001647:Bile Acids and Salts; D007773:Lactates; D019344:Lactic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin