[Monoclonal gammopathy of uncertain significance in rheumatic disease].
Among 358 patients with rheumatic diseases, the incidence of monoclonal gammopathy of undetermined significance (MGUS) as detected by immunofixation was 4.4% (11 of 248 patients) in rheumatoid arthritis (RA), 3% (1 of 32 patients) in systemic lupus erythematosus (SLE), 6% (3 of 49 patients) in Sjögren's syndrome (SS) and 3% (1 of 29 patients) in progressive systemic sclerosis (PSS). Solid tumor was present in 4 (36%) of the 11 RA-MGUS patients. In these cases the monoclonal component could be related to a paraneoplastic syndrome rather than to rheumatic diseases. The association of rheumatic diseases, MGUS, solid tumor and immunological disorders are discussed.
Broggini
M
M
Divisione di Medicina generale, Ospedale F. del Ponte, Varese.
Cavallo
A
A
Baratelli
E
E
Volonté
S
S
Crespi
E
E
Cappelli
A
A
Chelazzi
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000453:epidemiology; D012595:Scleroderma, Systemic / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*
Le grammapatie monoclonali di incerto significato nelle malattie reumatiche.