[In vitro prompt killing by chlorhexidine of human colorectal carcinoma cell lines].
Cell lines of human colorectal carcinoma were used to test the prompt killing effect of chlorhexidine in several concentrations of normal saline or distilled water 0.25g/L 5-fluorouracil in normal saline was used as positive control. Normal saline was used as negative control. It was found that chlorhexidine were more effective than 5-fluorouracil as shown by the proliferation of cells, the mitotic index and the morphology of cells. New passages of cells failed to proliferate and died in 19 days after chlorhexidine treatment. The authors came to the conclusion that 0.2g/L chlorhexidine in distilled water can be used for irrigation of the peritoneal and pelvic cavities on the end of colorectal carcinoma resection to prevent implantation metastasis and infection.
Xu
S H
SH
Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou.
D000230:Adenocarcinoma / Q000473:pathology*; D002430:Cecal Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002710:Chlorhexidine / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008940:Mitotic Index / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002710:Chlorhexidine