[Effect of dietary level of vitamin E on protection of fetus against ischemic distress induced by clamping the uterotubal vessels of pregnant rats].
The effect of dietary vitamin E on the fetal ischemic distress induced by clamping the uterotubal vessels of pregnant rats was studied. The fetal heart rate was measured by the pulsed doppler technique as an index of fetal distress induced by ischemia. On reperfusion after clamping the vessels for 9 min., the decreased fetal heart rate was restored to normal rapidly and completely in the E-supplemented group, but slowly and incompletely in the E-deficient and control groups. On reperfusion after ischemia, the amounts of lipid peroxides, measured as thiobarbituric acid (TBA)-reactive substances, were greatly increased in the fetal brain and liver and in the placenta in the E-deficient and control groups, but not in the E-supplemented group. The vitamin E concentrations in fetal tissues were less than 10% of those in the maternal tissues. But a diet containing a large amount of vitamin E induced significantly increased concentrations of vitamin E in fetal brain and liver. These results suggest that vitamin E may have a protective effect on fetal distress by decreasing lipid peroxides.
Iwasa
H
H
Department of Obstetrics and Gynecology, Tokushima University School of Medicine.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003250:Constriction; D005187:Fallopian Tubes; D005260:Female; D005316:Fetal Distress / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D005527:Food, Fortified; D006340:Heart Rate, Fetal; D007511:Ischemia / Q000150:complications*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000098:blood supply*; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D008054:Lipid Peroxides; D014810:Vitamin E