title: Evidence for mendelian inheritance in the pathogenesis of lung cancer.
abstract: Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produces earlier age of onset of the cancer. Segregation at this putative locus could account for 69% and 47% of the cumulative incidence of lung cancer in individuals up to ages 50 and 60, respectively. The gene was involved in only 22% of all lung cancers in persons up to age 70, a reflection of an increasing proportion of noncarriers succumbing to the effects of long-term exposure to tobacco.
authors.affiliation: Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans.
authors.forename: T A
authors.initials: TA
authors.lastname: Sellers
authors.forename: J E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: A F
authors.initials: AF
authors.lastname: Wilson
authors.forename: G Z
authors.initials: GZ
authors.lastname: Elston
authors.forename: W L
authors.initials: WL
authors.lastname: Ooi
authors.forename: H
authors.initials: H
authors.lastname: Rothschild
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002875:Chromosomes / Q000502:physiology; D004777:Environment; D005192:Family Health; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D010375:Pedigree; D012907:Smoking