title: Neuropsychologic "impairment" in a cohort of hospital workers chronically exposed to ethylene oxide.
abstract: Ethylene Oxide is widely used to sterilize heat-sensitive materials. Acute and chronic neurogenic effects to the central and peripheral nervous system in man and animals have been described. To assess the chronic, subtle neuropsychologic effects of ethylene oxide, we performed a cross-sectional study of 25 hospital central supply workers exposed to low levels of ethylene oxide and 24 unexposed control workers. Subjects were tested using a neuropsychological screening battery by examiners blinded to exposure status. Testing results were reviewed independently by two neuropsychologists without knowledge of exposure. Subject status was categorized as normal, "impaired," or disagreement (between the two neuropsychologists). There were significantly more subjects concordantly judged as impaired in the exposed group versus the control group (chi 2 (2) = 6.0861, p less than 0.05). Although limited by the cross-sectional study design and the global categorization, these findings suggest that CNS dysfunction and cognitive impairment may result from chronic ethylene oxide exposure in hospital central supply units.
authors.affiliation: Division of Occupational Medicine, University of California, San Francisco.
authors.forename: J E
authors.initials: JE
authors.lastname: Klees
authors.forename: A
authors.initials: A
authors.lastname: Lash
authors.forename: R M
authors.initials: RM
authors.lastname: Bowler
authors.forename: M
authors.initials: M
authors.lastname: Shore
authors.forename: C E
authors.initials: CE
authors.lastname: Becker
mesh_terms: D000328:Adult; D003071:Cognition / Q000187:drug effects; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D005027:Ethylene Oxide / Q000506:poisoning*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010564:Personnel, Hospital; D011596:Psychomotor Disorders / Q000139:chemically induced* / Q000453:epidemiology; D013242:Sterilization
chemical_list: D005027:Ethylene Oxide