title: Nickel-selenium interaction-time dependent biochemical alterations and metal decorporation in rats.
abstract: The influence of selenium on the disposition of nickel and on Ni induced metallothionein levels was studied in female rats. Concomitant administration of Se (6.3 mumol/kg, intraperitoneally) and 63Ni (0.12 mmol/kg subcutaneously) lowered the Ni burden of all the soft organs and the plasma ceruloplasmin levels. Selenium caused no potentiating effect on the Ni induced hepatic MT. However, 3 days later, the lowered MT levels appeared related to the corresponding decrease in hepatic Ni content at day 6. The Ni selenide excretable complex and Ni-selenide protein complex appear to be probable mechanisms of the Ni-Se interaction in the present study.
authors.affiliation: Industrial Toxicology Research Centre, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Khandelwal
authors.forename: S J
authors.initials: SJ
authors.lastname: Flora
authors.forename: S K
authors.initials: SK
authors.lastname: Tandon
mesh_terms: D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009532:Nickel / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000494:pharmacology*
chemical_list: D009532:Nickel; D008668:Metallothionein; D002570:Ceruloplasmin; D012643:Selenium