[Hematologic and biochemical characteristics of the effects of pentacaine in pregnant rabbits].
The effect of intragastric administration of pentacaine, a novel Czechoslovak local anesthetic with antiulcer and gastro-protective effect, was studied on the basis of hematological and biochemical parameters in pregnant white New Zealand rabbits. Pentacaine administration in doses of 1, 10, and 50 mg/kg from day 6 to 20 of gestation showed neither signs of toxic effect on hematological parameters, nor did it affect the activity of serum enzymes and the level of glucose, creatinine, urea, and total proteins. The presented results corroborate the safety of pentacaine administration on the applied biomodel.
Kristofová
A
A
Ustav experimentálnej farmakológie CFV SAV. Dúbravská, Bratislava.
Babinská
M
M
Ujházy
E
E
Nosál
R
R
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood* / Q000187:drug effects; D011817:Rabbits
D000779:Anesthetics, Local; D002219:Carbamates; C010618:pentacaine
Hematologická a biochemická charakteristika úcinkov pentakaínu u gravidných králikov.