title: Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents.
abstract: Zacopride administered orally was more emetic in fed than in fasted ferrets. The emetic activity of zacopride (0.1 mg/kg p.o.) was inhibited (100%) by 0.1 mg/kg i.p. of zacopride and 1 mg/kg i.p. of ICS 205-930. Haloperidol (3.16 mg/kg i.p.) and prochlorperazine (3.16 mg/kg i.p.) were weakly effective. N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, a 5-HT1P antagonist, was inactive. Thus, the emetic activity of zacopride, like that of cisplatin, is blocked by 5-HT3 receptor antagonists.
authors.affiliation: Department of Pharmacology, A.H. Robins Research Laboratories, Richmond, VA 23261-6609.
authors.forename: L F
authors.initials: LF
authors.lastname: Sancilio
authors.forename: L M
authors.initials: LM
authors.lastname: Pinkus
authors.forename: C B
authors.initials: CB
authors.lastname: Jackson
authors.forename: H R
authors.initials: HR
authors.lastname: Munson
mesh_terms: D000818:Animals; D000932:Antiemetics; D001549:Benzamides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001643:Bridged Bicyclo Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004639:Emetics; D005215:Fasting / Q000502:physiology; D005289:Ferrets; D006220:Haloperidol / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D011346:Prochlorperazine / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D000077526:Tropisetron
chemical_list: D000932:Antiemetics; D001549:Benzamides; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D018492:Dopamine Antagonists; D004639:Emetics; D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron; C055971:zacopride; D006220:Haloperidol; D011346:Prochlorperazine