[Effects of a lymph node extract on hemopoietic and lymphoid cells in normal state and in different forms of leukemia].
The chemical composition and properties of the lymphatic node extract (LNE) obtained from the porcine submandibular lymphatic nodes have been studied. It has been established that the LNE is the mixture of low-molecular weight peptides and the components of nucleic acids with the molecular mass below 2 kD. It possesses antiproliferative, immunosuppressive and antileukemic activities in vitro and in vivo. The inhibitory effect was the most pronounced in respect to lymphoid cells rather than myeloid cells of the patients with leukemia.
Fediakhina
R F
RF
Rybakova
L P
LP
Tutova
I Iu
IIu
D000818:Animals; D002478:Cells, Cultured; D004341:Drug Evaluation; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D007962:Leukocytes / Q000187:drug effects*; D008198:Lymph Nodes; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D051381:Rats; D013552:Swine; D014020:Tissue Extracts / Q000494:pharmacology* / Q000627:therapeutic use
D014020:Tissue Extracts
Vliianie ékstrakta limfaticheskikh uzlov na gemopoéticheskie i limfoidnye kletki v norme i pri razlichnykh formakh leĭkoza.