In vivo and in vitro inhibition of platelet aggregation by SV-IV, a major protein secreted from the rat seminal vesicle epithelium.
In summary, the present study documents that platelet aggregation triggered by thrombin, ADP, collagen and PAF both in vivo and in vitro, was prevented by SV-IV in a dose-dependent manner. Only platelet aggregation by AA was not affected by the protein, thus suggesting a possible involvement of PLA2 inhibition in the molecular mechanism at the basis of SV-IV anti-thrombotic effect.
Persico
P
P
Department of Experimental Pharmacology, University of Naples, Italy.
Mancuso
F
F
Metafora
S
S
Peluso
G
G
Ravagnan
G
G
Esposito
C
C
Porta
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D029589:Seminal Plasma Proteins; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000970:Antineoplastic Agents; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D003094:Collagen; D013917:Thrombin