title: [Current status of chemotherapy for colonic, rectal and anal carcinoma].
abstract: Despite great efforts chemotherapeutic results of metastatic colorectal cancer are still unsatisfactory. In general, single agent treatment with 5-fluorouracil is the standard. The combination of 5-fluorouracil and folinic acid, however, shows favorable preliminary results which can be expected to lead to a small progress in this area. During the last several years the treatment strategy of squamous cell cancer of the anus has changed profoundly. In most patients radical surgery with colostomy has become unnecessary. With combined simultaneous chemotherapy and radiotherapy about 80% of all patients can achieve long term disease free survival.
authors.affiliation: Abteilung Inner Medizin, Universitätsklinikum Rudolf Virchow der Freien Universität Berlin, Standort Charlottenburg.
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
mesh_terms: D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*
chemical_list: D002955:Leucovorin; D005472:Fluorouracil
vernacular_title: Gegenwärtiger Stand der Chemotherapie von Kolon-, Rektum- und Analkarzinomen.