title: 2-Imidazolethiones protect ascorbic acid from oxidation induced by copper.
abstract: The oxidation of ascorbic acid to dehydroascorbic acid was accelerated by metal ions such as copper. This stimulation of ascorbate oxidation was inhibited by the addition of 2-imidazolethiones and other sulfhydryl-containing compounds, but not by 2-imidazolones or phenytoin. Although the 2-imidazolethiones interacted with copper, as shown by a decrease in the ultraviolet absorbance of the compounds, the product formed still protected ascorbate from oxidation. The 2-imidazolethiones are proposed to complex copper through their free -SH groups.
authors.affiliation: Department of Animal and Dairy Sciences, Auburn University 36849-5415.
authors.forename: R C
authors.initials: RC
authors.lastname: Smith
authors.forename: J Z
authors.initials: JZ
authors.lastname: Gore
mesh_terms: D001205:Ascorbic Acid; D002851:Chromatography, High Pressure Liquid; D003300:Copper; D003545:Cysteine; D003553:Cystine; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013871:Thiones / Q000494:pharmacology*
chemical_list: D007093:Imidazoles; D013438:Sulfhydryl Compounds; D013871:Thiones; D003553:Cystine; D003300:Copper; D003606:Dacarbazine; D003545:Cysteine; D001205:Ascorbic Acid; C010243:5-(3-methyl-1-triazeno)imidazole-4-carboxamide