[Evaluation of BPA secretory ability from blood mono-nuclear cells in uremic patients after renal transplantation or rEpo treatment].
Conditioned media (CM) of phyto-hemagglutinin-stimulated lymphocytes from chronic uremic patients were studied for burst promoting activity (BPA), using methylcellulose cultures with cord blood cells as a target population. Renal transplantation procedure was followed by a prompt rise of BPA, as well as the number of blood burst-forming unit erythroid (BFU-E) and hemoglobin levels, while no change in BPA and blood BFU-E number was observed in patients receiving rEpo and recovering from anemia. Thus, low BPA secretion from blood cells may have a role in the development of anemia in uremic patients.
Abe
T
T
Department of Pediatrics, University of Tokushima.
Kawano
Y
Y
Takaue
Y
Y
Watanabe
T
T
Kuroda
Y
Y
Ninomiya
T
T
Minakuchi
J
J
Kawashima
S
S
D000328:Adult; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D009000:Monocytes / Q000502:physiology; D014511:Uremia / Q000097:blood* / Q000628:therapy
D004921:Erythropoietin