[Significance of the acetylator phenotype and initial oral/intravenous rifampicin administration in the treatment of tuberculosis].
In a pilot study involving 62 patients with open pulmonary tuberculosis, we established that slow acetyators and patients receiving intravenous rifampicin treatment showed a tendency towards a more rapid negativisation of the sputum culture than did fast acetyators (lower levels of isoniazid) or patients receiving oral rifampicin therapy (decreasing bioavailability of the rifampicin during treatment).
Loos
U
U
Medizinische Universitätsklinik Bonn.
Musch
E
E
Schwabe
H K
HK
D000107:Acetylation; D000284:Administration, Oral; D004977:Ethambutol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000502:physiology; D006899:Mixed Function Oxygenases / Q000235:genetics*; D010641:Phenotype; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D004977:Ethambutol; D006899:Mixed Function Oxygenases; D007538:Isoniazid; D012293:Rifampin
Bedeutung des Azetyliererphänotyps und der initialen oralen/intravenösen Rifampicingabe in der Tuberkulosebehandlung.