title: [The efficacy of antioxidant therapy in patients with tuberculosis of the lungs and the correction of lipid peroxidation processes].
abstract: The article deals with the efficacy of the antioxidative therapy in tuberculosis. Besides chemotherapeutic drugs, the administration of alpha-tocopherol, vitamin C and sodium nucleinate brings about higher rates of smear-negative cases and shorter period of cavity closure. In case of tuberculosis, lipid peroxidation (LPO) stimulation accompanied by a sharp drop of superoxide dismutase (SOD) enzyme activity is observed. This process is considered to be a manifestation of the decompensation taking place in the antiradical cell defense systems. In the course of treatment, the LPO level seems to decrease, while SOD activity and SOD/LPO ratio tend to rise. The comparison of the results obtained in every group indicated that a combined administration of alpha-tocopherol, vitamin C and sodium nucleinate proved to be the most effective.
authors.forename: M D
authors.initials: MD
authors.lastname: Safarian
authors.forename: K G
authors.initials: KG
authors.lastname: Karagezian
authors.forename: E T
authors.initials: ET
authors.lastname: Karapetian
authors.forename: N A
authors.initials: NA
authors.lastname: Avanesian
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000975:Antioxidants
vernacular_title: Effektivnost' antioksidantnoĭ terapii bol'nykh tuberkuleznom legkikh i korrektsiia protsessov perekisnogo okisleniia lipidov.