title: Osteocyte differentiation in the tibia of newborn rabbit: an ultrastructural study of the formation of cytoplasmic processes.
abstract: The morphological changes undergone by the osteoblast at the ultrastructural level, during its differentiation into osteocyte, were studied in the primary parallel-fibred bone of the newborn rabbit by means of incomplete three-dimensional reconstruction from partially serial-sectioned preosteocytes. The findings obtained suggest that the formation of osteocyte cytoplasmic processes is an asynchronous and asymmetrical phenomenon that seems to precede the mineralization of the organic matrix and to give rise to an asymmetrical mature osteocyte. The functions of cytoplasmic processes as regards bone formation, cell nutrition and osteoblast modulation are discussed. The mechanism by which the osteoblast 'enters' the bone matrix is hypothesized.
authors.affiliation: Istituto di Anatomia umana normale, Università di Modena, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Palumbo
authors.forename: S
authors.initials: S
authors.lastname: Palazzini
authors.forename: D
authors.initials: D
authors.lastname: Zaffe
authors.forename: G
authors.initials: G
authors.lastname: Marotti
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology* / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D003593:Cytoplasm / Q000648:ultrastructure; D007091:Image Processing, Computer-Assisted; D008854:Microscopy, Electron; D010006:Osteoblasts / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D010011:Osteocytes / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D011817:Rabbits; D013977:Tibia / Q000166:cytology / Q000196:embryology* / Q000648:ultrastructure