Muscle biopsy in AIDS and ARC: analysis of 50 patients.
We report a large spectrum of histological muscle abnormalities in 50 homosexual men with AIDS and ARC. We encountered moth-eaten fibers in 76%, angulated fibers in 76%, type groupings in 62%, type 2 fiber atrophy in 58%, mononuclear endomysial and/or perimysial and/or perivascular infiltrates in 36%, necrosis and phagocytosis in 30% and target fibers in 6%. Two patients showed vasculitis and two others showed perifascicular atrophy. On the whole, 96% of the biopsies showed substantial abnormalities. Muscle involvement in AIDS seems more common than previously suspected.
Gabbai
A A
AA
Department of Neurology, Escola Paulista de Medicina, Sao Paulo, Brazil.
Schmidt
B
B
Castelo
A
A
Oliveira
A S
AS
Lima
J G
JG
D000386:AIDS-Related Complex / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D000328:Adult; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000473:pathology*