Malignant transformation in fibrous dysplasia. A report of 3 cases.
Three patients with fibrous dysplasia were encountered in whom osteosarcoma subsequently developed. A review of published reports and the authors' experience establishes fibrous dysplasia as a premalignant bone lesion. Radiation appears to enhance the inherent tendency towards malignant transformation.
Chetty
R
R
Department of Anatomical Pathology, University of Cape Town.
Kalan
M R
MR
Kranold
D H
DH
D000328:Adult; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000150:complications*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000209:etiology*; D008875:Middle Aged; D012516:Osteosarcoma / Q000209:etiology*; D012888:Skull Neoplasms / Q000209:etiology*