title: [4 families with silent cholinesterase variant].
abstract: We report 4 patients who had apnea of variable duration after succinylcholine administration to facilitate orotracheal intubation during anesthesia. After ruling out other causes of apnea unrelated to succinylcholine, we genotyped the cholinesterase variants of these patients and their relatives measuring total plasmatic cholinesterase activity and using the inhibitors dibucaine and fluoride. We found the silent gene (Es1) both in homozygosis (2 cases) and heterozygosis, with the atypical gene (Ea11) (2 cases). The relevance of preoperative screening to prevent anesthetic accidents is emphasized.
authors.affiliation: Servicios de Análisis Clínicos y Bioquímica Clínica, Hospital Dr. Peset, Valencia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Moreno Monedero
authors.forename: D
authors.initials: D
authors.lastname: Acevedo León
authors.forename: S
authors.initials: S
authors.lastname: Caballero Ramón
authors.forename: J
authors.initials: J
authors.lastname: Vidal Martínez
authors.forename: A
authors.initials: A
authors.lastname: Moral Baltuille
authors.forename: G
authors.initials: G
authors.lastname: Perales Tortosa
authors.forename: E
authors.initials: E
authors.lastname: Casas Terrón
authors.forename: C
authors.initials: C
authors.lastname: Gil Minguillón
mesh_terms: D000328:Adult; D000368:Aged; D001049:Apnea / Q000139:chemically induced*; D002802:Cholinesterases / Q000097:blood / Q000235:genetics*; D005192:Family Health; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010375:Pedigree; D013390:Succinylcholine / Q000009:adverse effects*
chemical_list: D002802:Cholinesterases; D013390:Succinylcholine
vernacular_title: Estudio de cuatro familias con variante colinesterásica silente.