title: The effect of Hexabrix tracheobronchography on the ultrastructure of the airway epithelium.
abstract: The ultrastructure of the airway epithelium was studied after experimental Hexabrix tracheobronchography. Serious damage to the tracheal epithelium due to Hexabrix was recorded. 81 +/- 5% of goblet cells were stimulated to discharge mucus. 43 +/- 3% were completely exhausted and degenerated. The ciliated cells displayed vacuolar degeneration or severe pathological alteration. The average number of cilia/micron 2 fell to 3.3 +/- 0.5. As morphological signs of impaired self-cleaning ability the inspissated mucus and numerous bacteria appeared in the area of the disorganized ciliary border.
authors.affiliation: Research Institute for Child Development, Faculty of Pediatrics, University Hospital Motol, Prague, Czechoslovakia.
authors.forename: V
authors.initials: V
authors.lastname: Konrádová
authors.forename: S
authors.initials: S
authors.lastname: Tůma
authors.forename: J
authors.initials: J
authors.lastname: Kanta
mesh_terms: D000818:Animals; D001995:Bronchography; D002923:Cilia / Q000187:drug effects / Q000648:ultrastructure*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D007485:Ioxaglic Acid / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D014132:Trachea / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D007485:Ioxaglic Acid