Radioimmune localization of occult carcinoma.
Patients with a rising serum carcinoembryonic antigen level and no clinical or roentgenographic evidence of recurrent or metastatic cancer present a treatment dilemma. Eleven such patients, 10 with a previously treated colorectal carcinoma and 1 with a previously treated breast carcinoma, received an injection of the anticarcinoembryonic antigen monoclonal antibody ZCE-025 labeled with the radioisotope indium 111. Nuclear scintigraphy was performed on days 3 and 5 through 7 to detect potential sites of tumor recurrence. The monoclonal antibody scan accurately predicted the presence or absence of occult malignancy in 7 (64%) patients. Second-look laparotomy confirmed the monoclonal antibody scan results in the patients with colorectal cancer, and magnetic resonance imaging confirmed metastatic breast cancer. This study demonstrates that In-ZCE-025 can localize occult carcinoma and may assist the surgeon in facilitating the operative exploration. In-ZCE-025 assisted in the initiation of adjuvant therapy for the patient with breast cancer.
Duda
R B
RB
Department of Surgery, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Illinois 60611.
Zimmer
A M
AM
Rosen
S T
ST
Gilyon
K A
KA
Webber
D
D
Spies
S
S
Spies
W
W
Merchant
B
B
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002951:Citrates; D019343:Citric Acid; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D007205:Indium Radioisotopes; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009382:Neoplasms, Unknown Primary / Q000097:blood / Q000000981:diagnostic imaging*; D011859:Radiography; D011877:Radionuclide Imaging; D012086:Reoperation
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D002951:Citrates; D007205:Indium Radioisotopes; D019343:Citric Acid