[Immunomodulators with an 8-azasteroid structure as inducers of liver cytochrome P-450].
Two structural analogues of D-homo-8-azasteroids, both an immunostimulant and an immunodepressant, are inductors of the liver cytochrome P-450 in animals. This capability was shown by means of both a decrease of the hexenal sleep duration in the pharmacological test and an increase of the quantity of cytochrome P-450 and the rate of N-demethylation of aminopyrine in the biochemical assays.
Kuz'mitskiĭ
B B
BB
Dad'kov
I G
IG
Mashkovich
A E
AE
Stoma
O V
OV
Slepneva
L M
LM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001378:Azasteroids / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013260:Steroids, Heterocyclic / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D001378:Azasteroids; D007166:Immunosuppressive Agents; D013260:Steroids, Heterocyclic; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D010634:Phenobarbital
Immunomoduliatory 8-azasteroidnoĭ struktury kak induktory tsikhroma P-450.