[Physiopathology of neural death and of gliosis].
From a neurobiological point of view, three aspects have to be considered when elaborating a therapeutic strategy to improve functional recovery after an acute lesion of the central nervous system: prevention of secondary neuronal death and axonal lesions, stimulation of nerve cells regeneration and neuronal replacement by grafting. Two aspects of our research program will be discussed in this lecture: 1. The pathophysiology of secondary neuronal death. We will focus on a neuronotoxic activity released by astrocytes and whose presently established properties suggest its involvement in the pathophysiology of secondary cell death. These data open new prospects for the pharmacological approach of neuroprotection. 2. The pathophysiology of astrogliosis: our data suggest that the neuronal control of type one astrocytes proliferation is twofold: normal neurons release a proliferation inhibition factor (a 17 Kd protein for which we suggest the name astrostatine) while injured neurons release one or several astroglial mitogens.
Moonen
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Service de Physiologie humaine et de Physiopathologie, Institut Léon Fredericq, Université de Liège.
D001253:Astrocytes / Q000378:metabolism / Q000502:physiology; D002470:Cell Survival; D002478:Cells, Cultured; D005911:Gliosis / Q000503:physiopathology*; D006131:Growth Inhibitors / Q000096:biosynthesis; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D009474:Neurons / Q000502:physiology*; D009498:Neurotoxins / Q000378:metabolism
D006131:Growth Inhibitors; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; C063563:astrostatine
Physiopathologie de la mort neuronale et de la gliose.