title: A54145, a new lipopeptide antibiotic complex: microbial and chemical modification.
abstract: A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 complex was deacylated by Actinoplanes utahensis; three protected core peptides were isolated. A54145 antibiotic analogs were synthesized by acylation of the tryptophan N-terminus with 2,4,5-trichlorophenyl active esters, followed by deblocking with trifluoroacetic acid.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors.forename: D S
authors.initials: DS
authors.lastname: Fukuda
authors.forename: M
authors.initials: M
authors.lastname: Debono
authors.forename: R M
authors.initials: RM
authors.lastname: Molloy
authors.forename: J S
authors.initials: JS
authors.lastname: Mynderse
mesh_terms: D000192:Actinomycetales / Q000378:metabolism; D000215:Acylation; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism; D008969:Molecular Sequence Data
chemical_list: C065208:A54145; D000900:Anti-Bacterial Agents; D008074:Lipoproteins