Lovastatin-induced acute rhabdomyolysis.
Severe rhabdomyolysis complicated by respiratory and renal failure developed three weeks after initiation of low dose lovastatin therapy in a 79 year old, non-immunocompromised patient. The concomitant use of gemfibrozil may increase the risk of this complication.
Kogan
A D
AD
Department of Medicine, Loyola University, Evanston 60202.
Orenstein
S
S
D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D015248:Gemfibrozil / Q000009:adverse effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy; D008148:Lovastatin / Q000009:adverse effects* / Q000627:therapeutic use; D009132:Muscles / Q000473:pathology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology
D008148:Lovastatin; D015248:Gemfibrozil