The recovery from ultraviolet radiation-induced erythema and melanoma risk factors: a case-control study.
The proportion of subjects recovering from skin erythema induced by a single ultraviolet radiation challenge of 6 times the minimal erythema dose during a 3-week period was lower in 47 patients with stage I cutaneous melanoma than in 48 healthy control subjects with similar risk factors of increased sensitivity to ultraviolet radiation (p = 0.045). This difference indicates that the patients with melanoma were more susceptible to prolonged ultraviolet radiation-induced skin damage than the control subjects. Prolonged erythema response was significantly associated in the melanoma group with decreased minimal erythema doses (odds ratio [OR] = 11.3) and with the presence of freckles (OR = 5.5), and was associated in the control group with light eye color (OR = 5.8). Prolonged ultraviolet radiation-induced erythema is neither a unique feature of melanoma patients nor a useful marker for identifying risk groups for cutaneous melanoma.
Azizi
E
E
Department of Dermatology, Chaim Sheba Medical Center, Tel Aviv, Israel.
Wax
Y
Y
Lusky
A
A
Kushelevsky
A
A
Schewach-Millet
M
M
D000328:Adult; D016022:Case-Control Studies; D004198:Disease Susceptibility; D004890:Erythema / Q000209:etiology / Q000503:physiopathology*; D005127:Eye Color; D005260:Female; D005500:Follow-Up Studies; D006200:Hair Color; D006801:Humans; D008297:Male; D008545:Melanoma / Q000503:physiopathology*; D008548:Melanosis / Q000503:physiopathology; D008875:Middle Aged; D011829:Radiation Dosage; D012044:Regression Analysis; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000503:physiopathology*; D013471:Sunburn / Q000209:etiology / Q000503:physiopathology*; D014466:Ultraviolet Rays