title: Novel hypotensive peptides from the body of Elaphe climacophora.
abstract: Four hypotensive peptides called elapherine-A, -B, -C and -D were isolated from the body of Elaphe climacophora after removal of the internal organs. Elapherine-A, which had the lowest molecular weight, exhibited a prolonged fall for 5 min in the blood pressure of spontaneously hypertensive rats, whereas elapherin-B, -C and -D displayed a transient fall in the blood pressure. The molecular weights of elapherine-A---D estimated from sodium dodecyl sulfate (SDS) gel disk electrophoresis were 6600, 6900, 7000 and 7200, respectively. The isoelectric points of these peptides were 10.4, 10.6, 10.7 and 10.5, respectively. They possessed a single polypeptide chain of 34-35 (elapherine-A), 56-58 (elapherine-B), 56-57 (elapherine-C) and 52-53 (elapherine-D) amino acid residues.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsujibo
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kamatani
authors.forename: P T
authors.initials: PT
authors.lastname: Kenny
authors.forename: K
authors.initials: K
authors.lastname: Nomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Inamori
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012911:Snakes / Q000378:metabolism*
chemical_list: D000959:Antihypertensive Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C064851:elapherine A; C064852:elapherine B; C064853:elapherine C; C064854:elapherine D