Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.
The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked response than did similar stimulation in control medium. In addition, baclofen enabled stimulus trains, ordinarily subthreshold for LTP induction, to produce LTP. These results demonstrate that GABAB receptor activation by baclofen makes repetitive stimulation more effective at producing LTP.
Mott
D D
DD
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Lewis
D V
DV
Ferrari
C M
CM
Wilson
W A
WA
Swartzwelder
H S
HS
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001418:Baclofen