[Production of cyanide in the rat liver from 3-aminopropionitrile].
CN- Production was investigated from a saturated mononitrile, 3-aminopropionitrile, in small liver pieces and liver homogenates. Results show that CN- production is a function of time and of the concentration of active ingredient, with a trend to saturation in both cases. Similarly, cell integrity is not required for the biotransformation of 3-aminopropionitrile to occur. Cofactors such as NADPH must be present to reach high level activities. The effect of free radicals scavengers such as mannitol and DMSO was also studied.
Fernandez
G M
GM
Dpto. de Farmacología y Toxicología, Facultad de Veterinaria, Universitad Complutense, Madrid, España.
Lumbreras
J M
JM
Balaña
R
R
Ordoñez
D
D
D000629:Aminopropionitrile / Q000378:metabolism*; D000818:Animals; D003486:Cyanides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D003486:Cyanides; D009243:NAD; D000629:Aminopropionitrile; D009249:NADP
Production de cyanure dans le foie de rat à partir de 3-aminopropionitrile.