Severe self-poisoning with oxetorone: report of one case.
The authors report a case of severe self-poisoning with oxetorone. Plasma concentration of the drug assessed by HPLC was a thousand times higher than therapeutic levels. Coma, convulsions, and cardiac conduction defects were observed, similar to those noted with tricyclic and tetracyclic antidepressant poisoning. Similar cardiac disorders consisting of conduction defects had not been previously described during oxetorone intoxication.
Galerneau
V
V
Département d'Anesthésie et de Réanimation Chirurgicale, Université de Rouen, Hôpital Charles Nicolle, France.
Petit
J
J
Deghmani
M
M
Leroy
J
J
Droy
J M
JM
Leroy
A
A
Oksenhendler
G
G
Winckler
C
C
D000328:Adult; D001584:Benzoxepins / Q000097:blood / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D002998:Clonazepam / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced*; D004562:Electrocardiography; D004630:Emergencies; D005260:Female; D005751:Gastric Lavage; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy
D001584:Benzoxepins; D002998:Clonazepam; C011962:oxetorone