Inhibition of beta-glucuronidase in human urine by ascorbic acid.
The effects of oral supplementation of ascorbic acid (1500 mg d-1) on urinary beta-glucuronidase (beta-G) activity was assessed in a double-blind crossover study design over a 3-week period. The subjects on ascorbic acid treatment displayed a statistically significant (P less than 0.05) decrease in beta-G with an approximate decrease of 25%.
Young
J C
JC
Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst 01003.
Kenyon
E M
EM
Calabrese
E J
EJ
D000328:Adult; D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000652:urine; D004311:Double-Blind Method; D005966:Glucuronidase / Q000037:antagonists & inhibitors* / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010865:Pilot Projects; D011897:Random Allocation; D013997:Time Factors
D005966:Glucuronidase; D001205:Ascorbic Acid