[Action of carcinogenesis promoters on the adhesive force of cells in the liver, lung and thyroid gland in rats and mice].
The short-term effects of the carcinogenesis promoters on the adhesive force of cells are compared with the data from literature on their ability to exert a promoter action on the carcinogenesis development in the same organs during prolonged introduction after an initiator. The ability of substances to decrease the adhesive force in the tissue below the resistance threshold is established to correlate with its promoter activity. The coincidence of tissue specificity of both effects and active doses of substances is observed.
Kolotygina
I M
IM
Modianova
E A
EA
Malenkov
A G
AG
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002448:Cell Adhesion; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008168:Lung / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D051381:Rats; D013961:Thyroid Gland / Q000166:cytology* / Q000187:drug effects
D002273:Carcinogens
Deĭstvie promotorov kantserogeneza na silu stsepleniia kletok pecheni, legkikh i shchitovidnoĭ zhelezy u krys i mysheĭ.