title: Signal-to-noise ratio improvements in in vivo high resolution micro-volume selected spectroscopy.
abstract: A system capable of in vivo volume selected 1H NMR spectroscopy of voxels as small as 0.2 cm3 is described. Signal-to-noise ratio improvements with probe design and a novel signal steering device are detailed. A high-resolution, image-directed proton spectrum from 0.2 cm3 of a rat's brain at 200 MHz obtained using the SUBMERGE/SPACE pulse sequence is presented. Single-scan voxel shimming was implemented to improve spectral resolution.
authors.affiliation: Department of Chemistry, University of Queensland, St. Lucia, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Crozier
authors.forename: J
authors.initials: J
authors.lastname: Field
authors.forename: D M
authors.initials: DM
authors.lastname: Doddrell
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D004560:Electricity; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008433:Mathematics; D051381:Rats; D011919:Rats, Inbred Strains