Recovery of regional myocardial dysfunction after successful coronary angioplasty early after a non-Q wave myocardial infarction.
More aggressive therapy has been suggested for patients who have a non-Q wave myocardial infarction (MI) because of the frequency of subsequent unstable angina, recurrent MI, and high mortality rate compared to patients with Q wave MI. The present study was undertaken to investigate the effect of coronary angioplasty on regional myocardial function of the infarct zone in patients with angina early after a non-Q wave MI. The study population consisted of 36 patients undergoing successful coronary angioplasty within 30 days of a non-Q wave MI, in whom sequential left ventricular angiograms of adequate quality were obtained before the initial procedure and at follow-up angiography. The global ejection fraction increased significantly from 60 +/- 9% to 67 +/- 6% (p = 0.0003). This significant increase in the global ejection fraction was primarily due to a significant improvement in the regional myocardial function of the infarct zone. The results of the present study show not only that ischemic attacks early after a non-Q wave MI may lead to prolonged regional myocardial dysfunction but more important that this depressed myocardium has the potential to achieve normal contraction after successful coronary angioplasty.
Suryapranata
H
H
Thoraxcenter, University Hospital Rotterdam, The Netherlands.
Serruys
P W
PW
Beatt
K
K
De Feyter
P J
PJ
van den Brand
M
M
Roelandt
J
J
D000792:Angiography; D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013794:Thallium Radioisotopes; D013997:Time Factors
D013794:Thallium Radioisotopes