title: [Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].
abstract: The biocompatibility and pharmacokinetics of hydroxypropylmethylcellulose (HPMC) 2% (Adatocel) and Tylose 2% (MH 1000) were investigated. A modified anterior chamber implantation test on the rabbit eye is suitable for testing both the biocompatibility and the pharmacokinetics of visco-surgical substances. Both substances were well tolerated. From the fourth day onward, HPMC was no longer detectable in the anterior chamber by infrared spectroscopy.
authors.affiliation: Augenklinik der Universität des Saarlandes, Homburg/Saar.
authors.forename: W
authors.initials: W
authors.lastname: Ehrich
authors.forename: H
authors.initials: H
authors.lastname: Höh
authors.forename: C F
authors.initials: CF
authors.lastname: Kreiner
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects / Q000378:metabolism*; D001672:Biocompatible Materials; D005260:Female; D065347:Hypromellose Derivatives; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000633:toxicity; D011817:Rabbits; D013055:Spectrophotometry, Infrared
chemical_list: D001672:Biocompatible Materials; D065347:Hypromellose Derivatives; D008747:Methylcellulose
vernacular_title: Biologische Verträglichkeit und Pharmakokinetik von Hydroxypropylmethylcellulose (HPMC) in der Vorderkammer des Kaninchenauges.