title: [The action of aqueous solutions of dicaine and pyromecaine on the epithelium of the oral mucosa].
abstract: Buccal mucosa epithelium was studied by the cytological method in 70 patients before and after applications of 3% dicain and 2% pyromecain solutions. A statistically significant increase in the count of dissociated cells with altered nuclei and lysed cells were observed after application of 3% dicain, particularly so in the patients with aggravated case histories (i.e. with a history of multiple surgeries, with concomitant diseases). Applications of 2% pyromecain solution did not result in epitheliocyte changes in the patients with nonaggravated anamnesis; in the patients with aggravated anamnesis the count of cells containing catabolism products increased.
authors.forename: O F
authors.initials: OF
authors.lastname: Konobevtsev
authors.forename: N P
authors.initials: NP
authors.lastname: Polevaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D004341:Drug Evaluation; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects*; D011759:Pyrrolidines / Q000008:administration & dosage / Q000009:adverse effects*; D012996:Solutions; D013748:Tetracaine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000779:Anesthetics, Local; D011759:Pyrrolidines; D012996:Solutions; D013748:Tetracaine; C000661:bumecain
vernacular_title: Deĭstvie vodnykh rastvorov dikaina i piromekaina na épiteliĭ slizistoĭ obolochki polosti rta.