title: Polymorphic oxidation of debrisoquine in bladder cancer.
abstract: The oxidative polymorphism of debrisoquine has been determined in 125 patients with bladder cancer and in 556 healthy control subjects; 96.6% of patients and 93.9% of controls with a metabolic ratio of debrisoquine less than 12.6 were classified as extensive metabolizers of debrisoquine (P = NS). The distribution of frequencies of metabolic ratio values tended to have lower values in the patients (P less than 0.05), reflecting a higher oxidative rate of debrisoquine in urothelioma patients that cannot be explained solely in terms of enzymatic induction by drugs, tobacco or alcohol. Patients with a high occupational risk for urothelioma had lower metabolic ratio values (P = 0.03). Our results suggest that oxidative polymorphism of debrisoquine might be related to the pathogenesis of bladder cancer.
authors.affiliation: Department of Pharmacology, University of Extremadura, Badajoz, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Benítez
authors.forename: J M
authors.initials: JM
authors.lastname: Ladero
authors.forename: M J
authors.initials: MJ
authors.lastname: Fernández-Gundín
authors.forename: A
authors.initials: A
authors.lastname: Llerena
authors.forename: J
authors.initials: J
authors.lastname: Cobaleda
authors.forename: C
authors.initials: C
authors.lastname: Martínez
authors.forename: J J
authors.initials: JJ
authors.lastname: Muñoz
authors.forename: E
authors.initials: E
authors.lastname: Vargas
authors.forename: J
authors.initials: J
authors.lastname: Prados
authors.forename: F
authors.initials: F
authors.lastname: González-Rozas
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D007546:Isoquinolines; D003647:Debrisoquin