title: Acute renal failure in sickle cell anemia.
abstract: We performed a case-control study of acute renal failure (ARF) in patients hospitalized with sickle cell anemia (SCA). Twelve of the 116 patients (10.3%) whose records were suitable for analysis were diagnosed as having ARF based on a minimum of doubling of their serum creatinine levels (mean rise was 205 +/- 49%). ARF patients were more likely to have been admitted with infection and had a lower mean hemoglobin level than the control group. Volume depletion was the most common identifiable cause for ARF. Two of 3 patients with severe ARF received dialytic support. Ten of 12 ARF patients survived and subsequently had recovery of renal function.
authors.affiliation: Department of Medicine, Medical College of Georgia, Augusta.
authors.forename: A H
authors.initials: AH
authors.lastname: Sklar
authors.forename: J C
authors.initials: JC
authors.lastname: Perez
authors.forename: R J
authors.initials: RJ
authors.lastname: Harp
authors.forename: R J
authors.initials: RJ
authors.lastname: Caruana
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies