title: Allan-Herndon syndrome. II. Linkage to DNA markers in Xq21.
abstract: The original family with the Allan-Herndon type of X-linked mental retardation has been investigated for linkage by using DNA probes spanning the length of the X chromosome. Available for study, over 3 generations, were 13 affected males, three obligate carriers, and three normal sons of the obligate carriers. Initial disease-to-marker analysis suggested linkage to three markers (DXYS2 [7b], DXS250 [GMGX22], and DXS3 [p19-2]) located in Xq21. All three exhibited the same maximum lod score of 2.3 at a maximum theta of .05. Multipoint analysis using LINKMAP and a set of four DNA markers (DXYS1-DXYS2-DXS3-DXS94) gave a multipoint lod score of 3.58 for a location of the Allan-Herndon syndrome near locus DXYS1 (pDP34). Therefore, our data indicate that the gene for the Allan-Herndon syndrome is likely located in Xq21.
authors.affiliation: Greenwood Genetic Center, SC 29646.
authors.forename: C E
authors.initials: CE
authors.lastname: Schwartz
authors.forename: J
authors.initials: J
authors.lastname: Ulmer
authors.forename: A
authors.initials: A
authors.lastname: Brown
authors.forename: I
authors.initials: I
authors.lastname: Pancoast
authors.forename: H O
authors.initials: HO
authors.lastname: Goodman
authors.forename: R E
authors.initials: RE
authors.lastname: Stevenson
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D015342:DNA Probes; D005145:Face / Q000002:abnormalities; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D009135:Muscular Diseases / Q000235:genetics*; D010375:Pedigree; D013577:Syndrome; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers