title: Vasopressin-deficient paraventricular magnocellular neurons of homozygous Brattleboro rats synthesize neuropeptide Y.
abstract: Immunohistochemical study was carried out to determine whether neuropeptide Y (NPY), which was only found in certain experimental procedures in arginine vasopressin (AVP)-containing neurons of the magnocellular paraventricular nucleus, might also be synthesized in AVP-deficient homozygous Brattleboro (BB) rats. After an intraventricular colchicine administration, NPY was found in many AVP-deficient non-oxytocinergic magnocellular neurons of the paraventricular and supraoptic nuclei in BB rats, but not in suprachiasmatic nucleus neurons. The results suggest that the NPY synthesis is a phenotype of magnocellular non-oxytocinergic neurosecretory neurons and occurs independently from the synthesis of AVP.
authors.affiliation: Department of Anatomy, School of Medicine, University of Tokushima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kagotani
authors.forename: S
authors.initials: S
authors.lastname: Hisano
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuruo
authors.forename: S
authors.initials: S
authors.lastname: Daikoku
authors.forename: K
authors.initials: K
authors.lastname: Chihara
mesh_terms: D000818:Animals; D009478:Neuropeptide Y / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro / Q000378:metabolism*; D011922:Rats, Mutant Strains / Q000378:metabolism*; D014667:Vasopressins / Q000172:deficiency*
chemical_list: D009478:Neuropeptide Y; D014667:Vasopressins