The B cell antigen CD75 is a cell surface sialytransferase.
In this work we have isolated a cDNA clone encoding the B cell antigen CD75. The amino acid sequence of CD75 is shown to be identical to that of human alpha 2,6 sialyltransferase, believed to be primarily associated with the Golgi complex. This is the first demonstration of cell surface expression of sialytransferase which, in B cells, may play an important role in intercellular adhesion and antigen presentation events.
Stamenkovic
I
I
Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
Asheim
H C
HC
Deggerdal
A
A
Blomhoff
H K
HK
Smeland
E B
EB
Funderud
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D001483:Base Sequence; D002051:Burkitt Lymphoma; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D015723:Gene Library; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D012799:Sialyltransferases / Q000235:genetics*; D014162:Transfection
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D012799:Sialyltransferases