[Alcohol dehydrogenase inhibitors and their effect on major enzymatic systems involved in oxidation of aliphatic alcohols].
Effects of four main inhibitors of rat liver tissue alcohol dehydrogenase (4-methyl pyrasol, dimethyl sulfoxide, amide isovaleric acid and dioxime benzoylacetic aldehyde) were studied. Constants and type of inhibition of these substances were evaluate. Effects of these inhibitors on alternative pathways of aliphatic alcohols oxidation were studied: on microsomal ethanol oxidizing system, catalase, xanthine oxidase and on aldehyde dehydrogenases.
Kozhemiakin
L A
LA
Zelenin
K N
KN
Bonitenko
Iu Iu
IuIu
Ivanova
L I
LI
Ershov
A Iu
AIu
Zemlianoĭ
A V
AV
Koroliuk
M A
MA
D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000494:pharmacology; D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000438:Alcohols / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors; D000577:Amides / Q000494:pharmacology; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D002374:Catalase / Q000037:antagonists & inhibitors; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D000077604:Fomepizole; D006736:Horses; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010091:Oximes / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000438:Alcohols; D000577:Amides; D001565:Benzoates; D010091:Oximes; D011720:Pyrazoles; D000077604:Fomepizole; C038165:isovaleramide; D000426:Alcohol Dehydrogenase; D002374:Catalase; D014969:Xanthine Oxidase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D004121:Dimethyl Sulfoxide
Ingibitory alkogol'degidrogenazy i ikh vliianie na osnovnye fermentnye sistemy, okisliaiushchie alifaticheskie spirty.