title: Successful treatment of systemic blastomycosis with high-dose ketoconazole in a renal transplant recipient.
abstract: A case of disseminated blastomycosis in a male renal transplant recipient is presented. Discontinuation of immunosuppressive therapy and treatment with high-dose ketoconazole was successful in treating the patient's cutaneous and pulmonary disease initially. Ketoconazole was discontinued after 12 months of chronic therapy, but 2 weeks after discontinuation, blastomycosis recurred. High-dose ketoconazole was again effective; the patient remains asymptomatic presently on chronic suppressive therapy with ketoconazole.
authors.affiliation: Department of Microbiology, Toronto Hospital, Ontario, Canada.
authors.forename: J H
authors.initials: JH
authors.lastname: Hii
authors.forename: L
authors.initials: L
authors.lastname: Legault
authors.forename: G
authors.initials: G
authors.lastname: DeVeber
authors.forename: S I
authors.initials: SI
authors.lastname: Vas
mesh_terms: D000368:Aged; D001759:Blastomycosis / Q000188:drug therapy*; D002908:Chronic Disease; D003881:Dermatomycoses / Q000188:drug therapy; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D007654:Ketoconazole