title: [Characteristics of the occurrence of hematotoxic side effects of cytostatic drugs--results of a retrospective 10 year study of a district hospital].
abstract: From 1978 to 1988 in 77 patients of a district hospital, 58 females and 19 males, with malignant tumours or haemoblastoses a therapy with cytostatic agents was finished. A retrospective study analyses characteristics of haematotoxic side effects of cytostatic agents, which despite usual dosage according to the valid guide-lines have appeared in this patient population. According to this the granulocytopoiesis is injured most frequently and most severely. In one third of all patients under influence of cytostatic agents the number of the segment-nuclear granulocytes in the peripheral blood decreased deeper than 0.5 Gpt/l (severe neutropenia). In toxic influences on the thrombopoiesis slight and medium degrees of severity are dominating. Lesions of the erythropoiesis are apparently more infrequent, though they are more difficult to be proved. Further characteristics in the occurrence of severe neutropenias (date, dependence on age, pharmacological aspects) are demonstrated and discussed.
authors.affiliation: Inneren Abteilung, Kreiskrankenhauses Sebnitz.
authors.forename: E U
authors.initials: EU
authors.lastname: Radke
authors.forename: J
authors.initials: J
authors.lastname: Papke
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: A
authors.initials: A
authors.lastname: Hübler
authors.forename: K
authors.initials: K
authors.lastname: Mustafa
authors.forename: K
authors.initials: K
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Eichelroth
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced*; D010954:Plasmacytoma / Q000188:drug therapy; D012189:Retrospective Studies; D012307:Risk Factors; D013736:Testicular Neoplasms / Q000188:drug therapy; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Charakteristika des Auftretens hämatotoxischer Nebenwirkungen von Zytostatika--Ergebnisse einer retrospektiven Zehnjahresstudie eines Kreiskrankenhauses.