Postingestional effects of a high-protein diet on the regulation of food intake in monkeys.
Using a system in which the composition of an intragastric diet could be manipulated while oral factors were kept constant, we studied the effect of a high-protein diet on food intake. Four adult rhesus monkeys with chronically implanted intragastric cannulas were trained to use suction-activated food pumps that were monitored by computer so feeding pattern could be assessed over periods averaging 4 wk each. Each suck delivered the oral control diet while simultaneously activating a second pump, which delivered a second diet directly into the stomach, resulting in net diet compositions of either 14% or 50% protein. The calorie intake was consistently reduced by 24.7 +/- 1.6% when the high-protein diet was fed. The effect on intake was not due to increased diet osmolality. A doubling in plasma branched-chain amino acid concentration occurred when the high-protein diet was fed. These data indicate that feeding a high-protein diet results in a physiological appetite suppression, possibly mediated through branched-chain amino acids.
Hannah
J S
JS
Department of Physiology, School of Medicine, University of Maryland, Baltimore 21201.
Dubey
A K
AK
Hansen
B C
BC
D000596:Amino Acids / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000097:blood; D000818:Animals; D001835:Body Weight; D003201:Computers; D015930:Diet Records; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating / Q000502:physiology*; D002149:Energy Intake; D005247:Feeding Behavior; D008253:Macaca mulatta; D008297:Male; D009994:Osmolar Concentration
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D004044:Dietary Proteins