Prospective and retrospective analysis of colonoscopy findings in patients with a history of colorectal carcinoma in first-degree relatives.
The frequency of colorectal neoplasia was assessed by colonoscopy in 48 patients with a history of colorectal cancer in a first-degree relative. Twelve of these patients were found to have polyps in the colon, including 1 who had invasive cancer. Patients with multiple first-degree relatives who have a history of colorectal cancer were found to be at increased risk, 56% having colonoscopic findings positive for polyps. Of the 12 patients with positive colonoscopic findings, 5 (42%) had multiple lesions. These findings are similar to those reported in recent pedigree studies and further support a genetic basis for common colorectal cancer. First-degree relatives of patients with colorectal cancer should be considered a high-risk group for colorectal neoplasia. Screening with colonoscopy is recommended.
Brzezinski
W
W
University of Alberta, Edmonton.
Orrom
W J
WJ
Wiens
E
E
D000236:Adenoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000235:genetics; D003111:Colonic Polyps / Q000235:genetics; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk