title: Organic affective psychosis associated with the routine use of non-prescription cold preparations.
abstract: A patient experienced an organic affective psychosis on three separate occasions after taking recommended doses of non-prescription cold/sinus preparations. The possible underlying pharmacological mechanisms of this clinical reaction lend support to the cholinergic-adrenergic balance hypothesis of affective disorders. Recognition of this acute drug-induced state can lead to appropriate short-term pharmacotherapy and can prevent misdiagnosis of a major affective disorder or schizophrenia.
authors.affiliation: Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill 27599.
authors.forename: T M
authors.initials: TM
authors.lastname: Brown
authors.forename: R N
authors.initials: RN
authors.lastname: Golden
authors.forename: D L
authors.initials: DL
authors.lastname: Evans
mesh_terms: D003139:Common Cold / Q000188:drug therapy*; D004338:Drug Combinations; D006140:Guaifenesin / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000009:adverse effects*; D010656:Phenylephrine / Q000009:adverse effects / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000209:etiology*
chemical_list: D004338:Drug Combinations; D004366:Nonprescription Drugs; D010656:Phenylephrine; D006140:Guaifenesin