Immunohistologic analysis of epithelial cell populations in oral lichen planus.
Previous studies have demonstrated heterogeneity within lesional lymphocytes in drug-related oral lichen planus (D-LP) and idiopathic lichen planus (I-LP). This study examined the phenotype of Langerhans cells (LC) and keratinocytes in non-erosive D-LP and I-LP. In I-LP, keratinocytes expressed HLA-DR antigens whilst LC co-expressed CDIa, MHC Class II and CD4 antigens. The high levels of expression of MHC Class II antigens by LC were maintained during short term organ culture. In I-LP, the epithelium contained occasional CD25+ dendritic cells (putative activated LC). These cell phenotypes are suggestive of cell activation and likely result from local production of gamma interferon. In D-LP, expression of MHC Class II antigens on LC was reduced and no CD25+ cells were detected. The epithelium contained an increased number of CD45RA+ dendritic cells. While no differences between the production of interleukin-1 and interleukin-1 inhibitors by tissue samples could be detected, it is likely that the variations in epithelial cell phenotypes in I-LP and D-LP reflect altered cytokine production.
Walsh
L J
LJ
Department of Social and Preventive Dentistry, University of Queensland, Brisbane, Australia.
Ishii
T
T
Savage
N W
NW
Gemmell
E
E
Seymour
G J
GJ
D000328:Adult; D000368:Aged; D000943:Antigens, Differentiation / Q000032:analysis*; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology; D004848:Epithelium / Q000473:pathology; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D008010:Lichen Planus / Q000139:chemically induced / Q000473:pathology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
D000943:Antigens, Differentiation; D000949:Histocompatibility Antigens Class II