[Neutropenia caused by low-dose trimethoprim-sulfamethoxazole in children with chronic pathology of the urinary tract].
Neutropenia is the most common hematologic abnormality detected as consequence of Trimethoprim Sulfamethoxazole (TMP-SMX) therapy. Its incidence is evaluated in 27 children affected by urinary tract anomalies and treated with low doses of TMP SMX (2 + 10 mg/kg/die) for more than one month. A slight neutropenia was detected in 8 children (6 of these were in their first two years of life). In all the 27 cases a supplementation of folinic acid was started: a significant increase of PMN count was noted in all cases. Neutropenia can also appear after low (prophylactic) dosage of TMP-SMX, and can be prevented by concomitant administration of folinic acid.
De Manzini
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A
Clinica pediatrica. Istituto per l'Infanzia Burlo Garofolo Trieste, Italia.
Peratoner
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L
Lepore
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L
D000293:Adolescent; D000380:Agranulocytosis / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000517:prevention & control; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000517:prevention & control*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002955:Leucovorin
Neutropenia da trimetoprim-sulfametossazolo a basso dosaggio nei bambini con patologia cronica delle vie urinarie.