Renal transplant rejection. Transient immunodominance of HLA mismatches.
Many studies have shown long-term benefits of HLA matching in kidney transplantation. By examining rates of graft loss within consecutive posttransplant intervals, using data from the UK Transplant Service, we show that the long-term benefits of HLA matching are due to reduction of the graft failure rate within five months of transplantation. After 5-months, HLA-A,B,DR matching appears to have little impact on graft loss. We suggest that graft losses after 5 months may be attributable to non-HLA targets.
Gilks
W R
WR
Biostatistics Unit, Medical Research Council, Cambridge, England.
Gore
S M
SM
Bradley
B A
BA
D006084:Graft Rejection; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation
D006680:HLA Antigens; D006684:HLA-DR Antigens