Syntheses and antifungal activities of dl-griseofulvin and its congeners. I.
dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a. Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were undertaken.
Tomozane
H
H
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Takeuchi
Y
Y
Choshi
T
T
Kishida
S
S
Yamato
M
M
D000935:Antifungal Agents / Q000138:chemical synthesis*; D005658:Fungi / Q000187:drug effects; D006118:Griseofulvin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D006118:Griseofulvin