title: Changes in T1 relaxation processes in the bone marrow following treatment in children with acute lymphoblastic leukemia. A magnetic resonance imaging study.
abstract: Magnetic resonance imaging (MRI) and T1 relaxation time measurements of the vertebral bone marrow were performed in 11 children with acute lymphoblastic leukemia (ALL) at diagnosis. Nine of the children were re-examined after chemotherapeutic treatment. The results were compared with histological data from bone marrow biopsies obtained in close association to the MR examinations. Ten age matched children were examined as a control group. A 1.5 Tesla whole body scanner was used for the measurements. The pretreatment T1 relaxation times of the bone marrow were significantly prolonged, compared to the age matched controls. After chemotherapy the T1 relaxation times of the children with ALL decreased significantly towards or into the normal range. A significant correlation was found between the T1 relaxation time and the content of malignant blast cells in the bone marrow.
authors.affiliation: Department of Magnetic Resonance, Hvidovre Hospital, Denmark.
authors.forename: K E
authors.initials: KE
authors.lastname: Jensen
authors.forename: C
authors.initials: C
authors.lastname: Thomsen
authors.forename: O
authors.initials: O
authors.lastname: Henriksen
authors.forename: H
authors.initials: H
authors.lastname: Hertz
authors.forename: H K
authors.initials: HK
authors.lastname: Johansen
authors.forename: M
authors.initials: M
authors.lastname: Yssing
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000473:pathology*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents