title: Auditory event-related potentials and reaction times during simple sensorymotor tasks in subjects with sickle cell disease and related hemoglobinopathies.
abstract: 40 subjects of both sexes assigned to five groups of 8: healthy students, homozygous sicklemics, hemoglobin SC sicklemics, sickle cell Bo thalassemics, and sickle cell B+ thalassemics were subjected to 1/simple auditory stimuli; 2/paired auditory stimuli. The subjects were asked to respond quickly, by pressing a push button on detection of the simple stimulus or the unconditional stimulus of paired stimuli. A subsequent increase in reaction times and a reduction in event-related potential component amplitudes were obvious in major (SS and SC) sicklemics compared to controls and sickle cell B thalassemics. Between simple and paired auditory conditions, reaction times were more increased in sicklemics than in controls. These findings suggest that impairment of attentiveness, performance and cognitive capability in sicklemics is a function of sickle cell anemia severity.
authors.affiliation: Département de Biologie et Physiologie Animale. Laboratoire de Physiologie Animale et de Psychophysiologie. Faculté des Sciences et Techniques, Abidjan.
authors.forename: J F
authors.initials: JF
authors.lastname: Hamon
authors.forename: B
authors.initials: B
authors.lastname: Seri
authors.forename: A
authors.initials: A
authors.lastname: Sangare
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000503:physiopathology*; D003265:Contingent Negative Variation; D005072:Evoked Potentials, Auditory; D005260:Female; D006453:Hemoglobinopathies / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011930:Reaction Time; D012677:Sensation / Q000502:physiology*; D012805:Sickle Cell Trait / Q000503:physiopathology*