Long-term synaptic changes in rat cerebellar slices reflected in extracellular K+ activity.
In rat cerebellar slices, a [K+]o increase evoked locally by molecular layer stimulation was recorded by a K(+)-sensitive microelectrode. This K+ response was reduced clearly during application of low-Ca2+ medium, kynurenate or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Sustained depression of the K+ response by about 20% was observed after simultaneously but not after alternately combined stimulation of the molecular layer and the white matter/granule cell layer. It is concluded from these results that long-term depression of parallel fiber-Purkinje cell transmission can be detected as depression of the K+ response.
Shibuki
K
K
Laboratory for Neural Networks, Frontier Research Program, RIKEN, Saitama, Japan.
Okada
D
D
D000222:Adaptation, Physiological; D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials; D009433:Neural Inhibition; D011188:Potassium / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology*
D011188:Potassium