[Study of the intraperitoneal penetration of imipenem/cilastatin in acute peritonitis with perforation].
A study was performed to investigate the intraperitoneal penetration of Imipenem/cilastatin into inflammatory peritoneal fluid. Six patients undergoing abdominal surgery (acute peritonitis), were treated with Imipenem/cilastatin (4 perfusions of 0.5 g/day) during 5 days after the intervention. Plasma samples were obtained on day 1 and 4 at the pic and at the valley; peritoneal samples were obtained every days for 4 days, 1, 3 and 6 hours after the end of a perfusion. The samples were immediately stabilised following the manufacturer instructions and quick freezed at -80 degrees C. Dosages were performed using a microbiological assay. The mean peritoneal levels are above the MIC 90 of the more frequent bacteria which cause infection in abdominal surgery. Moreover none of the patients showed relapse of infection or complication during this treatment.
Pezé
P
P
Service de Chirurgie Générale B, CHU Dupuytren, Limoges.
Mounier
M
M
Cevallos
R
R
Denis
F
F
D000208:Acute Disease; D000368:Aged; D015377:Cilastatin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007416:Intestinal Perforation / Q000150:complications; D008297:Male; D010529:Peritoneal Cavity; D010538:Peritonitis / Q000150:complications / Q000378:metabolism* / Q000601:surgery
D015377:Cilastatin; D015378:Imipenem
Etude de la pénétration intrapéritonéale de l'imipénème/cilastatine au cours de péritonites aiguës avec perforation.