title: [Precocious pseudo-puberty in granulosa cell tumor in children less than 1 year old. 2 cases].
abstract: Two cases of isosexual precocity in relation to granulosa cell tumor in 2 girls aged 6 and 9 months respectively are described. In the two cases clinical and biological signs of hyperoestrogenemia were found but in one, acute signs of tumoral rupture were the first symptom. Histologically, the two classical subtypes were found: macrofollicular ("adult" type) and "juvenile". These two children are alive without any sign of recurrence with a follow up of 12 and 18 months. The occurrence of granulosa cell tumors in such young girls seems extremely rare.
authors.affiliation: Service de Chirurgie Pédiatrique, Hôpital Cl. Huriez, Lille.
authors.forename: M
authors.initials: M
authors.lastname: Bonnevalle
authors.forename: F
authors.initials: F
authors.lastname: Mazingue
authors.forename: B
authors.initials: B
authors.lastname: Nelken
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.forename: M
authors.initials: M
authors.lastname: Lecomte-Houcke
authors.forename: P
authors.initials: P
authors.lastname: Debeugny
mesh_terms: D004958:Estradiol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000097:blood / Q000150:complications*; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications*; D011629:Puberty, Precocious / Q000209:etiology*
chemical_list: D004958:Estradiol
vernacular_title: Pseudo-puberté précoce par tumeur de la granulosa chez des enfants de moins de 1 an. 2 cas.