Detection of beta-nerve growth factor mRNA in the human fetal brain.
Nerve growth factor (NGF) is a trophic molecule recently demonstrated to interact with different structures in the central nervous system. The expression of the beta-NGF mRNA from human fetal cortices at the 15-16th week of gestational age has been demonstrated and quantitated by polymerase chain reaction amplification of the specific cDNA. beta-NGF mRNA expression in the human brain coincides with the period of active differentiation and synaptogenesis, suggesting that the trophic agent plays a role in the cerebral development.
Pizzuti
A
A
Dino Ferrari Center, Institute of Neurology, University of Milan Medical School, Italy.
Borsani
G
G
Falini
A
A
Rugarli
E I
EI
Sidoli
A
A
Baralle
F E
FE
Scarlato
G
G
Silani
V
V
D001483:Base Sequence; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D004247:DNA / Q000235:genetics; D005333:Fetus; D006801:Humans; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics*; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics
D009414:Nerve Growth Factors; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D004247:DNA