[Polysaccharides in fungi. XXV. Biological activities of two galactomannans from the insect-body portion of Chán hua (fungus: Cordyceps cicadae)].
Biological activities of two galactomannans (CI-P and CI-A) isolated from the insectbody portion of Chán hua (fungus: Cordyceps cicadae) were studied. CI-P having low affinity for concanavalin A (Con A) exhibited potent carbon-clearance activity in mouse, although both polysaccharides had little antitumor activity against sarcoma 180 in mice. Furthermore, CI-P and CI-A was found to have potent hypoglycemic activity in normal mice, and CI-A having high affinity for Con A showed slightly higher activity than CI-P.
Kiho
T
T
Gifu Pharmaceutical University, Japan.
Nagai
K
K
Miyamoto
I
I
Watanabe
T
T
Ukai
S
S
D000818:Animals; D003208:Concanavalin A / Q000493:pharmacokinetics; D005690:Galactose / Q000031:analogs & derivatives; D006999:Hypocreales; D007004:Hypoglycemic Agents; D007915:Lepidoptera / Q000737:chemistry*; D008351:Mannans / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects
D007004:Hypoglycemic Agents; D008351:Mannans; D003208:Concanavalin A; C012990:galactomannan; D005690:Galactose