title: [Serological surveillance of West Nile virus infection in a village of the Central Highlands in Madagascar].
abstract: A serological survey on the frequency of West Nile virus antibodies has been carried out in a village near Antananarivo. IgG antibodies were searched for by enzyme-linked immunosorbent assay on 460 sera collected in December 1988 and on 494 sera collected in July 1989. The prevalence of West Nile virus antibodies varied from 13.4% to 21.8% between the beginning and the end of the rainy season. Seroconversion was observed in 14.7% of 354 paired serum samples collected in December and July which had been negative in December. The distribution of seropositive samples in the hamlets, and their frequency in relation to the presence of domesticated animals were analysed. Results show that West Nile virus circulates in the human population of the central highlands of Madagascar, which might account for the pseudo-influenza pathology observed in the region.
authors.affiliation: Institut Pasteur, Antananarivo, Madagascar.
authors.forename: J
authors.initials: J
authors.lastname: Morvan
authors.forename: D
authors.initials: D
authors.lastname: Fontenille
authors.forename: J P
authors.initials: JP
authors.lastname: Lepers
authors.forename: P
authors.initials: P
authors.lastname: Coulanges
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003465:Culex / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008270:Madagascar; D008297:Male; D008875:Middle Aged; D014902:West Nile virus / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000914:Antibodies, Viral
vernacular_title: Surveillance sérologique de l'infection à virus West Nile dans un village des hauts plateaux à Madagascar.