title: [Acute fatty degeneration of the liver in pregnancy].
abstract: Acute fatty liver of pregnancy is considered an uncommon disorder that may complicate the third trimester of pregnancy, with high fetal and maternal mortality rates. However, in recent years it has become clear that the course of the disorder can be less fulminant than previously believed. The diagnosis is also made more frequently. The case histories of three patients are described followed by a review of the clinical and diagnostic features. It is concluded that with all women showing symptoms of malaise, nausea, vomiting and upper abdominal pain in the third trimester of pregnancy liver enzymes should be measured. If evidence of liver dysfunction is found, acute fatty liver of pregnancy should be considered in the differential diagnosis. Only early recognition and prompt treatment will improve both fetal and maternal survival.
authors.affiliation: Afd. Gynaecologie en Obstetrie, Ziekenhuis Leyenburg, CH's-Gravenhage.
authors.forename: J A
authors.initials: JA
authors.lastname: Schueler
authors.forename: P A
authors.initials: PA
authors.lastname: Van De Lubbe
authors.forename: E J
authors.initials: EJ
authors.lastname: Van Erp
authors.forename: S J
authors.initials: SJ
authors.lastname: Smith
authors.forename: J P
authors.initials: JP
authors.lastname: Holm
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*
vernacular_title: Acute leververvetting in de zwangerschap.