The effect of pentachlorophenol and its metabolite tetrachlorohydroquinone on cell growth and the induction of DNA damage in Chinese hamster ovary cells.
It is shown that p-tetrachlorohydroquinone (TCH), the metabolite of the environmental chemical pentachlorophenol (PCP), is more toxic to cultured CHO cells than PCP, and that it causes DNA single-strand breaks and/or alkali-labile sites at concentrations of 2-10 microgram/ml as demonstrated by the alkaline elution technique.
Ehrlich
W
W
Institut für Biochemie und Molekularbiologie, Freie Universität Berlin, Germany.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002733:Chlorophenols / Q000633:toxicity*; D004249:DNA Damage; D006873:Hydroquinones / Q000633:toxicity*; D007700:Kinetics; D010416:Pentachlorophenol / Q000378:metabolism / Q000633:toxicity*
D002733:Chlorophenols; D006873:Hydroquinones; C044578:2,3,5,6-tetrachlorohydroquinone; D010416:Pentachlorophenol