title: A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.
abstract: Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5'-amino-5'-deoxy-5,6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Ezaki
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: M
authors.initials: M
authors.lastname: Okuhara
authors.forename: M
authors.initials: M
authors.lastname: Kohsaka
authors.forename: K
authors.initials: K
authors.lastname: Horikoshi
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D003521:Cyclopropanes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D009705:Nucleosides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013306:Streptomycetaceae / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D000935:Antifungal Agents; D003521:Cyclopropanes; D009705:Nucleosides; C065437:FR 900848