Hepatitis B in a highly active prostitute population: evidence for a low risk of chronic antigenemia.
The epidemiology of hepatitis B in female prostitutes was studied in a cross-sectional survey of 467 prostitutes and 510 control prenatal clinic patients from Lima and Iquitos, Peru. Prostitutes reported a mean of 8.8 +/- 6.7 years of active prostitution and a mean of 205 +/- 137 sexual contacts in the month prior to the study. Hepatitis B surface antigen (HBsAg) was found in comparable percentages of prostitutes (1.7%) and controls (0.8%; P = .305). In contrast, seropositivity for both antigen and antibody markers (HBsAg, anti-HBs, or anti-hepatitis B core) was found in a significantly higher percentage of prostitutes than controls (67.0% vs. 10.0%; P less than .0001). By multivariate analysis, both prostitution (odds ratio [OR] 14.6) and the number of years of exposure as a prostitute (OR 3.2 for 10 years of exposure at age 35 years) were significantly associated with seropositivity for hepatitis B markers when adjusted for age. In this study, the prevalence of HBsAg was not substantially increased in highly active female prostitutes compared with the general population, even though hepatitis B transmission was greatly increased. These data suggest that in adult women with a high level of hepatitis B infection, hepatitis B antigenemia may not persist as frequently as previously indicated in studies of other populations.
Hyams
K C
KC
US Naval Medical Research Institute Detachment, Rockville, MD 20852.
Phillips
I A
IA
Tejada
A
A
Li
O
O
Hermoza
P
P
Lopez
F
F
Alva
P
P
Chauca
G
G
Sanchez
S
S
Wignall
F S
FS
D000328:Adult; D000367:Age Factors; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007407:Interviews as Topic; D008875:Middle Aged; D015999:Multivariate Analysis; D010568:Peru / Q000453:epidemiology; D015995:Prevalence; D011477:Sex Work / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens