Separation of the enantiomeric intermediates of some platelet-activating factor analogues on a naphthylalanine-type Pirkle column.
A chiral high-performance liquid-chromatographic separation method was developed for the analysis of some glycerol-based, ether-linked platelet-activating factor precursors. Using a D-naphthylalanine-type Pirkle-column and tetrahydrofuran-hexane eluents, the retention-structure relationships were determined for a large number of glycerol ether derivatives. The derivatives leading to the highest chiral selectivity factors in the analytical separations were surveyed for their applicability in large-scale isolation of chiral synthetic intermediates.
Camacho
P L
PL
Chemistry Department, Texas A and M University, College Station 77843-3255.
Geiger
E
E
Vigh
G
G
Webster
R
R
Thompson
D H
DH
D000409:Alanine / Q000031:analogs & derivatives*; D002845:Chromatography / Q000379:methods; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000302:isolation & purification*; D013237:Stereoisomerism
D010972:Platelet Activating Factor; C059031:1-naphthylalanine; D000409:Alanine