Patch testing with the "sesquiterpene lactone mix": a marker for contact allergy to Compositae and other sesquiterpene-lactone-containing plants. A multicentre study of the EECDRG.
6278 patients were patch tested with a sesquiterpene lactone mix (SL-mix) in 10 European clinics. 4011 patients were tested only with 0.1% SL-mix, 63 (approximately 1.5%) of whom were positive, with 26 (41%) of these cases being considered clinically relevant. There were no cases of active sensitization, though 5 cases of irritation were reported. 22 irritant reactions and 22 cases of active sensitization occurred when testing also with 1% and 0.33% concentrations of SL-mix. SL-mix 0.1% pet. is shown to be an important patch test and many relevant sensitizations will be missed without routine screening with such a mix. Most patients with SL-mix sensitivity presented with hand and/or face dermatitis, apparent photodermatitis or more generalised eczema.
Ducombs
G
G
Hôpital Pellegrin, Clinique Dermatologique, Bordeaux, France.
Benezra
C
C
Talaga
P
P
Andersen
K E
KE
Burrows
D
D
Camarasa
J G
JG
Dooms-Goossens
A
A
Frosch
P J
PJ
Lachapelle
J M
JM
Menné
T
T
D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D005060:Europe; D005148:Facial Dermatoses / Q000175:diagnosis / Q000209:etiology; D006229:Hand Dermatoses / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007783:Lactones; D010328:Patch Tests / Q000379:methods*; D010936:Plant Extracts / Q000009:adverse effects; D010944:Plants / Q000276:immunology*; D012717:Sesquiterpenes; D012882:Skin Tests / Q000379:methods*
D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes