Adaptation of in vitro rat brain protein synthesis to long-term ingestion of n-butanol.
Long-term treatment of rats with n-butanol leads to a change in in vitro brain protein synthesis which increases the resistance of this process to either ethanol or isopropanol. The change seems to be related to ribosomal events since the synthesis of aminoacyl-tRNA was not affected in the same conditions.
Muñoz
R
R
Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
Ferreras
J M
JM
Iglesias
R
R
Merino
M J
MJ
Girbés
T
T
D020001:1-Butanol; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000440:Butanols / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010452:Peptide Biosynthesis; D010455:Peptides; D051381:Rats; D011919:Rats, Inbred Strains
D000440:Butanols; D009419:Nerve Tissue Proteins; D010455:Peptides; C012001:polyphenylalanine; D020001:1-Butanol; D008274:Magnesium