[The effect of the 5-lipoxygenase inhibitor quercetin on the functional and morphologic manifestations of myocardial lesions in ischemia and reperfusion of the heart].
In experimental canine myocardial infarction induced by an hour coronary artery occlusion, followed by 5-hour reperfusion, quercetin solution, 10 mg/kg, was demonstrated to improve left ventricular myocardial contractility, to reduce the incidence of rhythm and conduction disturbances, to promote the limitation of an ischemic lesion area, to produce a protective effect on the ultrastructure of coronary artery, contributing to the maintenance of vessel integrity, improvement of coronary blood flow, and prevention of intravascular thrombus formation.
Kolchin
Iu N
IuN
Popovich
L F
LF
Grabovskiĭ
L A
LA
Luĭk
A I
AI
Moĭbenko
A A
AA
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology / Q000648:ultrastructure; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors; D005419:Flavonoids / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D016859:Lipoxygenase Inhibitors; D008854:Microscopy, Electron; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D011794:Quercetin / Q000627:therapeutic use*
D004791:Enzyme Inhibitors; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D011794:Quercetin
Vliianie blokatora 5-lipoksigenazy kvertsetina na funktsional'nye i morfologicheskie proiavleniia porazheniia miokarda pri ishemii i reperfuzii serdtsa.