[Bronchopulmonary penetration of ciprofloxacin].
We determined ciprofloxacin levels in plasma, saliva, bronchial secretions, lavage fluid, and alveolar macrophages in 9 patients five hours following the last administration of the drug (2 x 750 mg ciprofloxacin daily over a period of at least 3 days). The ciprofloxacin concentration in the alveolar film was determined using urea as internal marker for the lavage. On average it was 2.51 micrograms/ml (= 186% of the plasma level), and clearly exceeded the minimal inhibition concentrations for the facultative pathogenic organism. This means that, in the alveolar film--which represents the barrier to descending pneumonia--an effective accumulation of the quinolone takes place.
Loos
U
U
Medizinische Universitätsklinik Bonn.
Marklein
G
G
Scholl
H
H
Schwabe
H K
HK
D001424:Bacterial Infections / Q000097:blood; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D011014:Pneumonia / Q000097:blood; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*
D002939:Ciprofloxacin
Bronchopulmonale Penetration von Ciprofloxacin.