title: Silicone implant to prevent visceral damage during adjuvant radiotherapy for retroperitoneal sarcoma.
abstract: The incidence of local recurrence after surgery for retroperitoneal sarcoma is reduced by high-dose adjuvant radiotherapy but treatment is restricted by the effects of irradiation on adjacent viscera. By securing a silicone gel-filled implant (breast prosthesis) in the tumour bed after excision of the tumour, adjacent viscera are displaced from the site of maximum irradiation and may thereby be protected. We used this technique in three patients in whom excision of a retroperitoneal sarcoma was followed by high-dose adjuvant radiotherapy. Post-operative radiotherapy was well tolerated but local recurrence developed in one patient, and delayed perforation of the large bowel occurred in another. Both cases underwent further surgery at which the implant was removed. The same two cases also developed asymptomatic hydronephrosis on the side of the implant, attributed to local fibrosis.
authors.affiliation: Academic Surgical Unit, Royal Marsden Hospital, London.
authors.forename: A B
authors.initials: AB
authors.lastname: Ball
authors.forename: A
authors.initials: A
authors.lastname: Cassoni
authors.forename: R M
authors.initials: RM
authors.lastname: Watkins
authors.forename: J M
authors.initials: JM
authors.lastname: Thomas
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D011832:Radiation Injuries / Q000517:prevention & control*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012186:Retroperitoneal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D012509:Sarcoma / Q000532:radiotherapy* / Q000601:surgery; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers