Disposition kinetics and dosage regimen of sulfadiadine in crossbred calves.
After a single intravenous administration (100 mg/kg) of sulfadiadine to calves, the distribution half-life, elimination half-life and volume of distribution were 0.353 +/- 0.071 h, 11.2 +/- 0.79 h and 0.55 +/- 0.08 l/kg, respectively. Total body clearance and tissue/plasma ratio were calculated to be 34.8 +/- 4.6 ml.kg-1.1-1 and 1.34 +/- 0.38, respectively. A satisfactory intravenous dosage regimen of sulfadiadine in the treatment of infections in calves would be 125 mg/kg, followed by 100 mg/kg at 24 h intervals.
Srivastava
A K
AK
GSF, Institut für Toxikologie, Munich, FRG.
Chaudhary
R K
RK
Raina
R
R
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002417:Cattle / Q000235:genetics / Q000378:metabolism*; D003433:Crosses, Genetic; D004334:Drug Administration Schedule; D008297:Male; D013411:Sulfadiazine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D013411:Sulfadiazine