[Is bronchial hypersensitivity in early childhood genetically determined?].
In order to study the familial occurrence of bronchial hypereactivity (BH) the parents of infants with BH were evaluated. 47 pairs of parents of infants aged 10-33 months were studied. All infants following spastic bronchitis developed BH. All parents had bronchial reactivity assessed. All answered a questionnaire from which the following data were retrieved: family history, personal history, environmental data and smoking habits. A similar analysis was carried out on a group of 19 pairs of parents forming a control group, derived randomly from hospital personnel. In parents of children with BH a higher incidence of BH was found in comparison with the control chi 2 = 11.52; p less than 0.01). In 14 subjects a positive familial history was found. This did not differ from the control. The smoking habit was seen more often in the study group that in the control (chi 2 = 9.82; p less than 0.01). These results allow us to state that familial factors play a role in bronchial hypereactivity in early infancy.
Gutkowski
P
P
Samodzielnej Pracowni Pulmonologicznej Oddziału Izolacyjno-Obserwacyjnego Centrum Zdrowia Dziecka.
Nowacka
K
K
Kluczek
M
M
Migdał
M
M
Zychowicz
C
C
D000328:Adult; D001249:Asthma / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D001980:Bronchi / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
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