title: Four years of experience with cyclosporin A for psoriasis.
abstract: Forty-four patients with severe psoriasis have been treated with cyclosporin A (CyA) for 2-50 months (mean 17 months). During the study, 31 (70%) of these patients achieved a greater than 70% reduction in PASI score, 39 (88%) achieved a greater than 60% reduction and 42 (95%) a greater than 50% reduction. The mean initial dose of CyA was 3 mg/kg/day and the mean dose was 3.3 mg/kg/day throughout the study. Twenty-five (57%) patients were maintained on less than or equal to 3 mg and six (14%) required greater than 5 mg/kg/day for limited periods to obtain significant improvement. In three of these patients, this was achieved with 6 mg/kg/day but, of the remainder, one required 7 mg and two required 10 mg/kg/day. Of the 44 patients, 32 (73%) are still taking CyA. Patients were discontinued because of: side-effects directly attributable to treatment (n = 4); remission of psoriasis (n = 4); death (n = I); defaulting (n = I); infrequent attendance (n = I); high doses of NSAID were necessary for arthritis (n = I). Before starting CyA, 39 patients were normotensive; 21 (54%) developed mild hypertension. In 28 patients where the GFRs were estimated before and during treatment, there was a 16% reduction (P less than 0.0001) during a mean period of 8 months. Two patients developed malignancies. The incidence of hypertension and percentage decrease in GFR were strongly correlated with the dose required to control the psoriasis.
authors.affiliation: Department of Dermatology, St Mary's Hospital, London, U.K.
authors.forename: A V
authors.initials: AV
authors.lastname: Powles
authors.forename: B S
authors.initials: BS
authors.lastname: Baker
authors.forename: H
authors.initials: H
authors.lastname: Valdimarsson
authors.forename: B
authors.initials: B
authors.lastname: Hulme
authors.forename: L
authors.initials: L
authors.lastname: Fry
mesh_terms: D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced
chemical_list: D003524:Cyclosporins; D003404:Creatinine