Studies on the relationship between chromosome No15 and the biological characteristics of malignant transformed Syrian hamster fibroblast cell lines.
During the course of malignant transformation of mammalian cells in vitro, a regular variation in chromosome number and structure is usually found. In order to elucidate the relationship between chromosomal changes and malignant expression, we isolated five clones from a malignant transformed Syrian hamster fibroblast cell line and analysed their biological characteristics, as well as chromosomal changes. A positive correlation between chromosome No 15 monosomy and the transformed and malignant phenotype was observed. We suggest that a suppression gene may be located on chromosome No 15, and its deletion or the loss of the chromosome may result in expression of the malignant phenotype.
Li
S
S
Cancer Institute, CAMS, Beijing.
Liu
B
B
Xu
D
D
D000818:Animals; D002461:Cell Line, Transformed; D002872:Chromosome Deletion; D006224:Cricetinae; D005347:Fibroblasts / Q000166:cytology; D005354:Fibrosarcoma / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D008168:Lung / Q000166:cytology*; D008647:Mesocricetus; D008769:Methylnitronitrosoguanidine; D009006:Monosomy; D009368:Neoplasm Transplantation; D010641:Phenotype
D008769:Methylnitronitrosoguanidine