Small animal MRI at 0.35 Tesla: growth and morphology of intra-organ murine tumors.
A whole-body small animal radiofrequency coil was designed and built for use with a 0.35 Tesla clinical magnetic resonance imager. The primary motivation for this work was to evaluate the effectiveness of this system for small animal magnetic resonance imaging of tumor-bearing mice. This noninvasive technique is shown to provide high resolution whole-body images of mice, to be capable of detecting intra-organ tumors, and to be useful for evaluating tumor size and growth. Its potential for monitoring response to experimental therapeutic regimens is also noted. Two tumor models were examined--colon adenocarcinoma MCA-38 and human ASPC-1 pancreatic adenocarcinoma.
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T M
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Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York 14263.
Fiel
R J
RJ
Goldrosen
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M
Paolini
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D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary; D000818:Animals; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000175:diagnosis*