title: Metabolic pathways of sodium bisulfite injected intravenously in rabbits.
abstract: The metabolites of sodium bisulfite in rabbits through intravenous injection were examined according to the high performance liquid chromatography method for determination of sulfur-containing substances. Most of the administered sulfite was oxidized to sulfate, and a small part was converted to thiosulfate, S-sulfoalbumin, S-sulfoglutathione and S-sulfocysteine. Furthermore, it was found that S-sulfocysteine administered intravenously to a rabbit was partially changed to inorganic sulfate and thiosulfate. These metabolites produced from sulfite in rabbits indicated the presence of the many and complicated metabolic pathways of sulfite in vivo.
authors.affiliation: Department of Analytical Chemistry, Meiji College of Pharmacy, Yato-cho Tanashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Togawa
authors.forename: S
authors.initials: S
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: I
authors.initials: I
authors.lastname: Koshiishi
authors.forename: T
authors.initials: T
authors.lastname: Toida
authors.forename: T
authors.initials: T
authors.lastname: Imanari
mesh_terms: D000818:Animals; D000838:Anions / Q000097:blood; D002850:Chromatography, Gel; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood; D007275:Injections, Intravenous; D009153:Mutagens / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D013447:Sulfites / Q000008:administration & dosage / Q000378:metabolism*; D013451:Sulfonic Acids / Q000097:blood; D013455:Sulfur / Q000097:blood
chemical_list: D000838:Anions; D009153:Mutagens; D013447:Sulfites; D013451:Sulfonic Acids; D013455:Sulfur; C011119:S-sulphocysteine; D003545:Cysteine; C009279:sodium bisulfite