title: The inhibitory effect of ionizing radiation on Fc and C3 receptors on mouse and human leukocytes, and the protective potential of human albumin.
abstract: The effect that ionizing radiation has in vitro on Fc and C3 receptors was evaluated at various doses and measured by means of erythrocytes coated with antibody (EA) and erythrocytes coated with antibody and complement (EAC) rosettes on human peripheral blood leukocytes (PBL) and on mouse bone marrow cells (BMC) and PBL. We found that the number of cells with either EA and EAC rosettes decreased as the radiation doses increased, and that they were almost absent when the highest doses were employed. We obtained evidence that albumin is a natural source of radio-protection for Fc and C3 receptors, and we showed that by increasing the amount of this molecule we could completely protect receptors for EA and EAC in vitro. Finally, the possible therapeutic value of the administration of human albumin to patients undergoing radiotherapy is discussed.
authors.affiliation: Laboratory of Cellular Diferentiation and Cancer, ENEP-Zaragoza, National University of Mexico, Mexico City.
authors.forename: M A
authors.initials: MA
authors.lastname: Herrera
authors.forename: R
authors.initials: R
authors.lastname: Díaz-Perches
authors.forename: M
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: E
authors.initials: E
authors.lastname: Gamminio
authors.forename: C
authors.initials: C
authors.lastname: Liera
authors.forename: P
authors.initials: P
authors.lastname: Nieto
authors.forename: B
authors.initials: B
authors.lastname: Weiss-Steider
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D011837:Radiation-Protective Agents; D011951:Receptors, Complement / Q000378:metabolism*; D011961:Receptors, Fc / Q000378:metabolism*; D012397:Rosette Formation; D012709:Serum Albumin
chemical_list: D011837:Radiation-Protective Agents; D011951:Receptors, Complement; D011961:Receptors, Fc; D012709:Serum Albumin