title: Cholecystokinin, secretin, pancreatic polypeptide in relation to gallbladder dynamics and gastrointestinal interdigestive motility.
abstract: Using a combined technique of hepatobiliary scintigraphy and gastrointestinal motility recordings, the changes in blood concentrations of cholecystokinin (CCK), secretin and pancreatic polypeptide (PP) were studied in relation to gastrointestinal motility and gallbladder dynamics in the interdigestive state in 7 healthy male volunteers. No changes in CCK concentration were found in relation to the migrating motor complex (MMC). In 3 subjects a slightly but insignificant elevated secretin level was seen during phase I of the MMC, otherwise no changes were observed. More pronounced fluctuations in PP appeared with significantly higher values during phase III compared to phase II. Values of concentrations of CCK, secretin and PP in periods with gallbladder filling were not significantly different from the values in periods of emptying.
authors.affiliation: Department of Surgical and Medical Gastroenterology, Odense University Hospital, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Qvist
authors.forename: E
authors.initials: E
authors.lastname: Oster-Jørgensen
authors.forename: L
authors.initials: L
authors.lastname: Rasmussen
authors.forename: S A
authors.initials: SA
authors.lastname: Pedersen
authors.forename: O
authors.initials: O
authors.lastname: Olsen
authors.forename: P
authors.initials: P
authors.lastname: Cantor
authors.forename: O B
authors.initials: OB
authors.lastname: Schaffalitzky de Muckadell
mesh_terms: D000328:Adult; D000818:Animals; D001646:Bile / Q000378:metabolism; D001659:Biliary Tract / Q000000981:diagnostic imaging; D002766:Cholecystokinin / Q000097:blood*; D004063:Digestion / Q000502:physiology; D005704:Gallbladder / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007098:Imino Acids; D008297:Male; D015609:Organotechnetium Compounds; D010191:Pancreatic Polypeptide / Q000097:blood*; D011877:Radionuclide Imaging; D051381:Rats; D012633:Secretin / Q000097:blood*; D019780:Technetium Tc 99m Lidofenin
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D012633:Secretin; D010191:Pancreatic Polypeptide; D019780:Technetium Tc 99m Lidofenin; D002766:Cholecystokinin