[Effects of beta adrenergic blocking agents and calcium antagonists on atherogenic properties of blood serum of patients with ischemic heart disease].
The beta-adrenoblockers anapriline and visken and the calcium antagonist corinfar were studied for effects on the atherogenic properties of the sera from patients with coronary heart disease who took the drugs. The study was performed by using cultured atherosclerotically altered human aortic smooth muscle cells. A single dose of anapriline, 80 mg, and that of visken, 20 mg, were found to give rise to or to enhance atherogenic properties of the patients' sera, while that of corinfar, 20 mg, yielded their antiatherosclerotic properties.
Kozlov
S G
SG
Orekhov
A N
AN
Tertov
V V
VV
Liakishev
A A
AA
Baldenkov
G N
GN
Li Khva Ren
Bocharova
O I
OI
Ruda
M Ia
MIa
D000328:Adult; D002478:Cells, Cultured; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D010869:Pindolol / Q000494:pharmacology* / Q000627:therapeutic use; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D011433:Propranolol; D010869:Pindolol; D009543:Nifedipine
Vliianie beta-adrenoblokatorov i antagonistov kal'tsiia na aterogennye svoĭstva syvorotok krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa.