title: In vivo estimates of hepatic binding protein concentration: correlation with classical indicators of hepatic functional reserve.
abstract: Hepatic binding protein (HBP) is a hepatic cell surface receptor specific for asialoglycoprotein. In vivo estimates of HBP concentration ([HBP]) were compared to classical indicators for hepatic functional reserve to clarify the validity of [HBP] in estimating the hepatic functional reserve in 30 humans. Estimates of [HBP] were obtained based on kinetic analysis of liver and blood time-activity data resulting from the hepatic clearance of a single injection of technetium-99m galactosyl-neoglycoalbumin, which is a synthetic analog radioligand specific to HBP. Estimates of [HBP] ranged 0.054 to 0.720 microM. Estimates of [HBP] in normal volunteers were 0.668 +/- 0.050 microM, whereas that in liver cirrhosis were 0.188 +/- 0.112 microM. The difference between the mean values of [HBP] estimates was statistically significant (p = 0.0001). Good correlations were observed between [HBP] and prothrombin time (r = 0.625, p = 0.0002), serum albumin level (r = 0.687, p = 0.0001), serum cholinesterase level (r = 0.764, p = 0.0001), indocyanine green plasma disappearance rate (r = 0.602, p = 0.0024), and Child-Turcotte classification score (Pugh's modification) (r = -0.797, p = 0.0001). We concluded that excellent correlations of [HBP] with classical indicators for hepatic functional reserve suggest potential value of [HBP] as a sensitive measure of functioning hepatocyte mass.
authors.affiliation: Division of Gastroenterology, Kobe City General Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kudo
authors.forename: D R
authors.initials: DR
authors.lastname: Vera
authors.forename: R C
authors.initials: RC
authors.lastname: Stadalnik
authors.forename: W L
authors.initials: WL
authors.lastname: Trudeau
authors.forename: K
authors.initials: K
authors.lastname: Ikekubo
authors.forename: A
authors.initials: A
authors.lastname: Todo
mesh_terms: D000328:Adult; D000368:Aged; D037263:Asialoglycoprotein Receptor; D001663:Bilirubin / Q000097:blood; D002352:Carrier Proteins / Q000378:metabolism*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D005690:Galactose / Q000378:metabolism*; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D037263:Asialoglycoprotein Receptor; D002352:Carrier Proteins; D012709:Serum Albumin; C027122:hepatic sialoglycoprotein receptor; D002802:Cholinesterases; D007208:Indocyanine Green; D001663:Bilirubin; D005690:Galactose