Chronic administration of phosphatidylserine during ontogeny enhances subject-environment interactions and radial maze performance in C57BL/6 mice.
A longitudinal behavioral study was performed in mice exposed to the bovine brain phospholipid phosphatidylserine (BC-PS) from birth until sixty days. Examination of treated and control pups revealed no effect of the treatment on body weight nor on sensorimotor reflexes. At one and two months of age, when placed in an open field and, particularly, in the presence of a novel object, treated mice were found more interactive with their environment than control mice. Finally, when submitted to a radial eight-arm maze problem, choice accuracy was higher and maze-running strategies more adaptive in treated than in control adult mice. These results suggest a stimulating effect of the treatment on subject-environment interactions during ontogeny underlying improved cognitive abilities in adulthood.
Ammassari-Teule
M
M
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Fagioli
S
S
Maritati
M
M
Populin
R
R
Pavone
F
F
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects*; D005260:Female; D006120:Grooming / Q000187:drug effects; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009949:Orientation / Q000187:drug effects*; D010718:Phosphatidylserines / Q000494:pharmacology*; D011247:Pregnancy
D010718:Phosphatidylserines