Changes in the esophageal epithelium in rabbits treated by Cis-dichlorodiammineplatinum as studied by electron microscopy.
The esophageal mucosa of the rabbit was investigated after a single dose of 5 mg Cis-Dichlorodiammineplatinum (Cis-DDP). Specimens were taken for scanning electron microscopy, transmission electron microscopy, and light microscopy. Examination was performed daily for 20 consecutive days. A cytotoxic effect was observed already the first day after injection with an intracellular oedema. Thereafter the height of the esophageal epithelium and the basal cell layer steadily decreased to a minimum day 11. This parallels the damaged microridges and an increased cell loss as revealed by scanning electron microscopy. At the end of the observation period the esophageal mucosa had completely restituted.
Albertsson
M
M
Department of Oncology, University Hospital, Lund, Sweden.
Hakansson
C H
CH
Palmegren
M
M
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004947:Esophagus / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits
D002945:Cisplatin