title: [Prospective study of primary and secondary prevention of Pneumocystis carinii pneumonia with pentamidine aerosol].
abstract: In an open prospective study in the AIDS Outpatient Department of the Frankfurt University Clinic the efficacy of pentamidine aerosol at a dosage of 200 mg every 14 days in the primary and secondary prophylaxis of pneumocystis carinii pneumonia was tested. The incidence of pneumocystis carinii pneumonia was reduced by more than 75% in the group of patients receiving pentamidine additionally by inhalation as compared with a historical cohort given azidothymidine alone. The results of the study suggest that a CD4-positive cell count of less than 50/microliters with a concomitant secondary lung infection promotes the development of pneumocystis carinii pneumonia. There was no correlation between the incidence of pneumocystis carinii pneumonia and the number of previous disease episodes. No systemic toxicity of pentamidine aerosol was established.
authors.affiliation: Zentrum der Inneren Medizin, Infektiologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankturt a. M.
authors.forename: S
authors.initials: S
authors.lastname: Staszewski
authors.forename: S
authors.initials: S
authors.lastname: Trinder
authors.forename: A
authors.initials: A
authors.lastname: Gottstein
authors.forename: J
authors.initials: J
authors.lastname: Odewald
authors.forename: S
authors.initials: S
authors.lastname: Rehmet
authors.forename: R
authors.initials: R
authors.lastname: Brodt
authors.forename: V
authors.initials: V
authors.lastname: Jacobi
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Müller
authors.forename: E B
authors.initials: EB
authors.lastname: Helm
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000280:Administration, Inhalation; D000328:Adult; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000517:prevention & control*; D010419:Pentamidine / Q000008:administration & dosage*; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D010419:Pentamidine
vernacular_title: Prospektive Studie zur Primär- und Sekundärprophylaxe der Pneumocystis-carinii-Pneumonie mit Pentamidin-Aerosol.