title: The renal excretion of pethidine administered postoperatively to male dogs.
abstract: The urinary excretion of pethidine and its major metabolite, norpethidine, was investigated in four male dogs given pethidine as a postoperative analgesic. The urinary excretion of pethidine in the first 4 h after drug administration was low at 1.9% of the administered dose. The percentage of the drug excreted as norpethidine was also low at 3.7% but there was a great deal of individual variation. Urinary excretion, therefore, appears to be a minor route in the clearance of pethidine in the dog.
authors.affiliation: Department of Veterinary Surgery, University of Bristol, Langford.
authors.forename: W
authors.initials: W
authors.lastname: Kalthum
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman
mesh_terms: D000818:Animals; D004285:Dogs / Q000652:urine*; D008614:Meperidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine*; D011184:Postoperative Period
chemical_list: D008614:Meperidine; C002752:normeperidine