[A comparative study of the action of liver extracts from C57Bl and CBA mice on hepatocyte adhesion].
The adhesiometric methods were used for the investigation of influence of the preparations extracted from liver of CBA mice, predisposed to spontaneous blastomogenesis, and stable C57BL mice on cell adhesion. The extraction was carried out at 4 degrees C or 20 degrees C under condition of Ca2(+)-deficiency, so four preparations were investigated. The differences in adhesive activity between these liver preparations of two mouse lines were determined. The influence of the liver extracts (20 degrees C) from C57BL and CBA mice on cell adhesion was different. These preparations from C57BL mice contained the cell surface and membrane connected adhesion factors. The liver extracts (4 degrees C) from C57BL mice contained the cell surface adhesion factors influenced adhesive properties of hepatocytes under condition of cell surface preservation, and acted only on hepatocytes of C57BL mice. Our results concluded that, first, there were different adhesion factors extracted at 4 degrees C and 20 degrees C in liver preparations from C57BL mice; second, there was the strong change in cell surface of CBA mouse hepatocytes.
Iamskova
V P
VP
Tumanova
N B
NB
Loginov
A S
AS
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology*; D008808:Mice, Inbred CBA / Q000502:physiology*; D013696:Temperature; D014020:Tissue Extracts / Q000494:pharmacology*
D046911:Macromolecular Substances; D014020:Tissue Extracts
Sravnitel'noe issledovanie deĭstviia ékstraktov pecheni mysheĭ linii C57Bl i CBA na adgeziiu gepatotsitov.