Antineoplastic agents, 178. Isolation and structure of lychnostatins 1 and 2 from the South American Lychnophora antillana.
Bioassay-guided (P388 lymphocytic leukemia cell line) separation of a CH2Cl2/MeOH extract of Lychnophora antillana led to the isolation of two cytostatic (P-388, ED50 2.0 and 0.19 micrograms/ml, respectively) germacranolides designated lychnostatins 1 [1] and 2 [2]. Structural elucidation was based initially upon high field (400 MHz) nmr and electron impact mass spectral interpretations and unequivocally completed by X-ray crystal structure determinations.
Pettit
G R
GR
Cancer Research Institute, Arizona State University, Tempe 85287.
Herald
D L
DL
Cragg
G M
GM
Rideout
J A
JA
Brown
P
P
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D010944:Plants / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C064679:lychnostatin 1; C064680:lychnostatin 2