Vitamin C influence on localized adjuvant arthritis.
This work attempts to determine the influence of vitamin C on locally induced inflammation and arthritis in rat paws, as measured by rat paw swelling, polymorphonuclear leukocyte infiltration, pain, and surface skin temperature. Daily subcutaneous administration of 150 mg/kg of vitamin C over 20 days reduced arthritic swelling, increased pain tolerance, and decreased polymorphonuclear leukocyte infiltration, with no significant change in surface temperature. Vitamin C may provide podiatrists with a supplemental or alternative treatment for patients with rheumatoid arthritis.
Davis
R H
RH
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Rosenthal
K Y
KY
Cesario
L R
LR
Rouw
G R
GR
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D004195:Disease Models, Animal; D004487:Edema / Q000209:etiology / Q000473:pathology; D008297:Male; D010146:Pain / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D001205:Ascorbic Acid