Learning-induced change in neural activity during acquisition and consolidation of a passive avoidance response in the rat.
Time-dependent alterations in neural activity have been established during the acquisition and consolidation of a stepdown passive avoidance paradigm. Change in neural activity was established by administering a glucose analogue, [3H]2-deoxyglucose, 50min prior to sacrifice and estimating perchloric acid soluble counts in nine hand dissected brain regions. Change in [3H]2-deoxyglucose uptake was closely paralleled in both trained and yoked animals for up to 40min following task acquisition however the striatum was the only area to exhibit a task-specific increase in [3H]2-deoxyglucose uptake at 20-30min after training. Longterm changes in neural activity were also apparent as the amygdala and brainstem showed increased [3H]2-deoxyglucose uptake at the 24 h time point. No further paradigm-specific changes were apparent at 48 h. These findings are concluded to suggest that the striatum is involved in the early events of acquiring a passive avoidance response and the amygdala and brainstem during the later events.
Doyle
E
E
Department of Pharmacology, University College, Belfield, Dublin, Ireland.
Nolan
P M
PM
Regan
C M
CM
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D003847:Deoxyglucose / Q000378:metabolism; D004597:Electroshock; D006624:Hippocampus / Q000502:physiology; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003847:Deoxyglucose