title: Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat.
abstract: Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enhanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.
authors.affiliation: Clinical Brain Disorders Branch, NIMH Research Center at St. Elizabeths, Washington, DC 20032.
authors.forename: G E
authors.initials: GE
authors.lastname: Jaskiw
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D002243:Carbolines / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects*; D007051:Ibotenic Acid / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology / Q000523:psychology*
chemical_list: D002243:Carbolines; D010080:Oxazoles; D007051:Ibotenic Acid; C035874:FG 7142