title: Effects of methamphetamine on regional cerebral glucose utilization in rats with unilateral lesion of substantia nigra.
abstract: In rats with electrocoagulation of the unilateral substantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats.
authors.affiliation: Department of Hospital Pharmacy, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Gomita
authors.forename: Y
authors.initials: Y
authors.lastname: Ichimaru
authors.forename: K
authors.initials: K
authors.lastname: Furuno
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
mesh_terms: D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000187:drug effects*; D003847:Deoxyglucose; D004564:Electrocoagulation; D005947:Glucose / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D013378:Substantia Nigra / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D008694:Methamphetamine; D003847:Deoxyglucose; D005947:Glucose