Uricosuric effect of different doses of irtemazole in normouricaemic subjects.
Irtemazole 12.5 to 50 mg in 6 healthy, normouricaemic subjects caused a maximal decrease in plasma uric acid (after 8 to 12 h) of 46.5%. The uricosuric effect began during the first 60 min after drug administration and it lasted for 7 to 24 h. Renal uric acid excretion returned to its base line value after 8 to 16 h and uric acid clearance after 10.0 to 12.0 h. Doses of irtemazole between 12.5 and 37.5 mg produced a dose-related rise in the uricosuric effect. There was no essential difference between the uricosuric effect of 37.5 mg and 50 mg irtemazole. The D50 dose (that producing a half-maximal effect) was between 16.3 mg and 34.2 mg, (average 24.7 mg). The value of irtemazole in the management of hyperuricaemia and gout remains to be determined.
Gresser
U
U
Medizinische Poliklinik, Universität München, West Germany.
Kamilli
I
I
Kronawitter
U
U
Zöllner
N
N
D000328:Adult; D001562:Benzimidazoles / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000097:blood* / Q000652:urine; D014528:Uricosuric Agents / Q000009:adverse effects / Q000494:pharmacology*
D001562:Benzimidazoles; D014528:Uricosuric Agents; D014527:Uric Acid; C060889:irtemazole