[Pharmacokinetics and toxicokinetics of pentamidine in the rat following intravenous and aerosol administration].
Within the framework of toxicity studies with pentamidine aerosol the pharmacokinetics and toxicokinetics of the active substance was investigated. The plasma kinetics after intravenous administration show a strong distribution into tissues. The validity of toxicity studies was demonstrated by quantitative tissue analysis. The highest pentamidine concentrations were found in the target organ lung with a long elimination half life. The benefit of lower systemic side effects of the aerosol compared to the intravenous administration could be shown by comparative investigations. These studies were also used for doses calculations after aerosol administration.
Terlinden
R
R
Rhône-Poulenc/Nattermann Cologne Research Centre, Köln.
Römer
A
A
D000284:Administration, Oral; D000818:Animals; D007262:Infusions, Intravenous; D008657:Metabolic Clearance Rate / Q000502:physiology; D010419:Pentamidine / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution / Q000502:physiology
D010419:Pentamidine
Pharmakokinetik und Toxikokinetik von Pentamidin in der Ratte nach intravenöser und Aerosolgabe.