[Clinical feature and laboratory findings of multiple organ failure].
The pathology of multiple organ failure consists of tissue-cell damage (disruption of energy metabolism) and severe infections (host exhaustion). The impairment of the TCA cycle was mild in two-organ disease but was nearly arrested in three-organ disease, and the cells are considered to have been in lactic acidosis with a shift of the glycolytic system from pyruvate to lactate. Significant differences were observed also in the number and the function of lymphocytes between two-organ and three-organ diseases. Therefore, in multiple organ failure, infections are considered to worsen as the ability of antigen recognition is impaired and differentiation of B cells into antibody-producing cells is inhibited with a decrease in lymphocytes. The phagocytic activity of neutrophils did not decrease unless leukocytes were reduced.
Kaku
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N
Critical Care Center, Kurume University School of Medicine.
D002952:Citric Acid Cycle; D004734:Energy Metabolism; D006801:Humans; D007239:Infections / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009102:Multiple Organ Failure / Q000276:immunology / Q000378:metabolism*