A rapidly reversible effect of a single dose of phenoxybenzamine on the fertility of male rats.
Male Sprague-Dawley rats received a single subcutaneous injection of phenoxybenzamine and each was allowed to mate with an untreated receptive female at 5, 29 or 53 h post-injection. At 5 h the number of males ejaculating was reduced and fertility virtually abolished; at 29 h all males ejaculated, but fertility was still low; at 53 h the performance of the males was normal.
Kessedjian
M J
MJ
Centre de Recherche, Laboratoires Pfizer, Amboise, France.
Monro
A M
AM
Stadler
J
J
D000818:Animals; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D010643:Phenoxybenzamine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013997:Time Factors
D010643:Phenoxybenzamine