title: Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A.
abstract: Staphylococcus aureus D4508, obtained from a patient with nonmenstrual toxic shock syndrome (TSS), produced enterotoxin A while not making other known enterotoxins or TSS toxin 1. Concentrated culture fluids of the organism, administered subcutaneously in miniosmotic pumps, induced TSS-like symptoms (four of six animals succumbed). Identical culture fluids pretreated with anti-enterotoxin A serum failed to induce symptoms except for fever (none of six animals succumbed). Purified staphylococcal enterotoxin A also had the ability to induce TSS-like symptoms. These data suggest that enterotoxin A is the major TSS-associated toxin made by strain D4508.
authors.affiliation: Department of Microbiology, University of Minnesota, Minneapolis 55455.
authors.forename: B D
authors.initials: BD
authors.lastname: McCollister
authors.forename: B N
authors.initials: BN
authors.lastname: Kreiswirth
authors.forename: R P
authors.initials: RP
authors.lastname: Novick
authors.forename: P M
authors.initials: PM
authors.lastname: Schlievert
mesh_terms: D000818:Animals; D003470:Culture Media; D004768:Enterotoxins / Q000096:biosynthesis* / Q000502:physiology; D011817:Rabbits; D012772:Shock, Septic / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*
chemical_list: D003470:Culture Media; D004768:Enterotoxins; C026066:enterotoxin A, Staphylococcal