title: Resting energy expenditure in interstitial lung disease.
abstract: Because interstitial lung disease increases the work of breathing, the aim of this study was to determine if this condition is associated with increased energy requirements. A group of 12 clinically stable patients with interstitial lung disease was studied. Patients with a history of weight loss had significantly more severe lung volume restriction. Regression analysis showed that 42% of body weight variation was explained by vital capacity (p less than 0.025). Resting energy expenditure was measured by standard methods of indirect calorimetry. The measurements were performed with a ventilated hood during prolonged steady-state periods after an overnight fast. We found that resting energy expenditure was increased to 117.3 and 118.7% of the predicted basal metabolic rate, according to Fleisch and to Harris and Benedict reference values, respectively (p less than 0.001). Furthermore, resting energy expenditure was increased to 120.8% of the predicted value according to body fat-free mass (p less than 0.001). This extra energy expenditure in patients with interstitial lung disease is similar to that recently reported in patients with chronic obstructive pulmonary disease.
authors.affiliation: Département de Médecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: J W
authors.initials: JW
authors.lastname: Fitting
authors.forename: P
authors.initials: P
authors.lastname: Frascarolo
authors.forename: E
authors.initials: E
authors.lastname: Jéquier
authors.forename: P
authors.initials: P
authors.lastname: Leuenberger
mesh_terms: D000328:Adult; D000368:Aged; D001481:Basal Metabolism; D001835:Body Weight; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000503:physiopathology; D011659:Pulmonary Gas Exchange; D012115:Residual Volume; D013961:Thyroid Gland / Q000503:physiopathology; D014109:Total Lung Capacity; D014797:Vital Capacity