Mouse strain differences in plasma corticosterone following uncontrollable footshock.
Exposure to acute inescapable footshock provoked marked increases of plasma corticosterone concentrations in six strains of mice (A/J, Balb/cByJ, C57BL/6J, C3H/HeJ, DBA/2J and CD-1). However, the magnitude of the increase, as well as the time required for corticosterone to return to control values, varied appreciably across strains. Moreover, it appeared that the strain-specific corticoid increases ordinarily observed after acute shock were also evidence following a chronic stressor regimen. The data were related to previously observed strain differences in stressor-induced alterations of brain norepinephrine, dopamine and serotonin, as well as variations in performance in several behavioral paradigms.
Shanks
N
N
Department of Psychology, Carleton University, Ottawa, Ontario, Canada.
Griffiths
J
J
Zalcman
S
S
Zacharko
R M
RM
Anisman
H
H
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004597:Electroshock; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology
D003345:Corticosterone