Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder.
Serotonin receptors of the 5-HT2 type were studied on platelet membranes from 15 patients suffering from major depression. Receptor binding and clinical state (assessed by the Hamilton and Beck rating scales) were examined in a drug free state upon admission and after 1 and 3 weeks of treatment with the antidepressant maprotiline (MPT). 5-HT2 receptor binding changed in correlation with changes in the clinical state of the patients as judged by the rating scales. Since most patients showed a clinical improvement, the patients as a group exhibited a significant decrease in binding concomitant with a drop in depression scores. However, in those patients in whom there was no clinical change or an increase in depression scores, 5-HT2 receptor binding did not change or increased, respectively, thus resulting in a significant correlation between clinical changes and changes in binding. These results support the use of 5-HT2 receptors on platelets in evaluating depression and its treatment.
Biegon
A
A
Weizman Institute of Science, Rehovot, Israel.
Essar
N
N
Israeli
M
M
Elizur
A
A
Bruch
S
S
Bar-Nathan
A A
AA
D000328:Adult; D000368:Aged; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood / Q000523:psychology; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008376:Maprotiline; D008875:Middle Aged; D019964:Mood Disorders / Q000097:blood* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000378:metabolism*
D015415:Biomarkers; D011985:Receptors, Serotonin; D008376:Maprotiline; D007650:Ketanserin