HLA typing in actinic prurigo.
Thirty-two actinic prurigo patients of Cree ancestry underwent human lymphocyte antigen (HLA) typing and were compared with 32 control subjects of Cree ancestry. We found a significantly increased frequency of HLA-A24 and Cw4 antigens and a significant decrease in the frequency of the A3 antigen in actinic prurigo patients. These HLA associations may be helpful in determining whether actinic prurigo is a distinct disease or a variant of polymorphous light eruption.
Sheridan
D P
DP
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Lane
P R
PR
Irvine
J
J
Martel
M J
MJ
Hogan
D J
DJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000235:genetics / Q000276:immunology*; D011536:Prurigo / Q000235:genetics / Q000276:immunology*; D012525:Saskatchewan
D006680:HLA Antigens