Therapeutic effects of the joint administration of magnesium aspartate and adenosine monophosphate in gamma irradiated mice.
The joint administration of magnesium aspartate and adenosine monophosphate, injected on days 1 to 4 post radiation, has been found to exert stimulatory effects on the recovery of hemopoietic functions in sublethally gamma irradiated mice. These therapeutical effects were enhanced in animals protected by peroral administration of cystamine. The treatment scheme used did not modify survival of lethally irradiated mice. The therapeutic effects of magnesium aspartate and adenosine monophosphate in sublethally irradiated mice are explained by the stimulatory action of these drugs on the cell adenylate cyclase system, which influences the erythropoietic functions.
Pospísil
M
M
Institute for Biophysics, Czechoslovak Academy of Sciences, Brno, CSSR.
Netiková
J
J
Pipalová
I
I
Kozubík
A
A
D000249:Adenosine Monophosphate / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D003037:Cobalt Radioisotopes; D004359:Drug Therapy, Combination; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*
D003037:Cobalt Radioisotopes; D001224:Aspartic Acid; D000249:Adenosine Monophosphate