Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy.
Ochratoxin A (OA), a mycotoxin which induces nephropathy and kidney tumours in rats and mice, is a contaminant of food consumed by a population with a high incidence of endemic nephropathy (EN). It was therefore tested in vitro for its ability to induce chromosomal aberrations in human peripheral lymphocytes in a small number of subjects, in the presence or absence of a kidney microsomal metabolic activation system. OA was found to induce aberrations on X chromosomes of similar types to those previously detected in lymphocytes from patients suffering from endemic nephropathy.
Manolova
Y
Y
National Oncological Center, Bulgarian Medical Academy, Sofia.
Manolov
G
G
Parvanova
L
L
Petkova-Bocharova
T
T
Castegnaro
M
M
Chernozemsky
I N
IN
D000818:Animals; D001449:Balkan Nephropathy / Q000209:etiology / Q000235:genetics; D001711:Biotransformation; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D007668:Kidney / Q000378:metabolism; D008214:Lymphocytes; D008861:Microsomes / Q000378:metabolism; D009793:Ochratoxins / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D014314:Trisomy; D014960:X Chromosome
D009793:Ochratoxins; C025589:ochratoxin A