title: Leukotoxic activity of Clostridium perfringens of equine origin.
abstract: Leukotoxic activity of equine isolates of Clostridium perfringens type A was examined. Thirty-seven isolates (94.9%) of 39 isolates demonstrated leukotoxic effects on mouse peritoneal macrophages. Phase contrast microscopy revealed that the toxic preparations induced rounded protoplasmic extrusion and sometimes destruction of the cells, leaving some membrane fragments. These findings suggest that the leukotoxic activity could be considered to be a virulence factor of C. perfringens.
authors.affiliation: Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kanoe
authors.forename: S
authors.initials: S
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D002470:Cell Survival; D003015:Clostridium Infections / Q000382:microbiology / Q000662:veterinary*; D003016:Clostridium perfringens / Q000472:pathogenicity*; D003603:Cytotoxins / Q000494:pharmacology; D005098:Exotoxins / Q000494:pharmacology*; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; C018579:leukotoxin