title: Airflow limitation in morbidly obese, nonsmoking men.
abstract: OBJECTIVE
  To determine the effect of obesity on pulmonary function.
  
  
  METHODS
  Case-control study, using nonobese, age- and height-matched [corrected] nonsmokers.
  
  
  METHODS
  Metabolic and obesity clinics of two major teaching hospitals.
  
  
  METHODS
  One hundred and three obese, lifelong nonsmokers without cardiopulmonary disease.
  
  
  METHODS
  One hundred and ninety healthy, nonobese nonsmokers recruited from among hospital personnel.
  
  
  RESULTS
  Complete pulmonary function measurements in all patients and controls. These measurements included maximum expiratory flow-volume curve, lung volumes and airway resistance using body plethysmograph, single-breath diffusing capacity for carbon monoxide, and total lung capacity using the helium dilution technique. Obese persons were found to have lower functional residual capacity, expiratory reserve volume, and total lung capacity by helium dilution than nonobese controls. In addition, residual volume and diffusing capacity were higher in the obese group. Finally, we found that obese men, but not women, had reduced maximum expiratory flow rates at 50% and 75% of exhaled vital capacity.
  
  
  CONCLUSIONS
  Obesity may contribute independently of smoking habits to chronic airflow limitation in men.
authors.affiliation: St. Michael's Hospital, Toronto, Ontario.
authors.forename: I
authors.initials: I
authors.lastname: Rubinstein
authors.forename: N
authors.initials: N
authors.lastname: Zamel
authors.forename: L
authors.initials: L
authors.lastname: DuBarry
authors.forename: V
authors.initials: V
authors.lastname: Hoffstein
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000209:etiology; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000503:physiopathology*; D012123:Pulmonary Ventilation / Q000502:physiology*; D012129:Respiratory Function Tests; D012737:Sex Factors; D012907:Smoking; D013223:Statistics as Topic