title: Chronic supraventricular tachycardia causes ventricular dysfunction and subendocardial injury in swine.
abstract: Chronic supraventricular tachycardia has been associated with ventricular dysfunction in humans and animals. However, this ventricular failure is poorly characterized, and the ultrastructural consequences of supraventricular tachycardia are unknown. We serially examined right and left ventricular function, endomyocardial ultrastructure, and creatine kinase activity in eight pigs at base line and again at 1, 2, and 3 wk following rapid atrial pacing. Left and right ventricular ejection fractions fell significantly from base line after 1 wk of chronic tachycardia. Three weeks of chronic pacing resulted in further deterioration in ejection fractions. Significant biventricular chamber dilatation developed and was associated with a reduction in end-diastolic wall thickness after 2 wk of tachycardia. Mitochondrial injury and diminished mitochondrial cytochrome oxidase staining of subendocardial myocytes were observed after 2 wk of tachycardia. Endomyocardial creatine kinase activity fell from control levels following 2 wk of pacing. Postmortem examination revealed a reduction in left ventricular wall thickness compared with 14 control animals. Fibrosis occurred along the subendocardial layer in paced animals, and glycogen content was also reduced. In summary, chronic supraventricular tachycardia resulted in severe biventricular pump dysfunction and chamber dilatation that were associated with ultrastructural alterations and reduced enzyme activity of the subendocardial myocytes. These ultrastructural and metabolic changes may be potential mechanisms responsible for the ventricular dysfunction and dilatation observed in this model.
authors.affiliation: Department of Comparative Medicine, Medical University of South Carolina, Charleston 29425.
authors.forename: F G
authors.initials: FG
authors.lastname: Spinale
authors.forename: D A
authors.initials: DA
authors.lastname: Hendrick
authors.forename: F A
authors.initials: FA
authors.lastname: Crawford
authors.forename: A C
authors.initials: AC
authors.lastname: Smith
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: B A
authors.initials: BA
authors.lastname: Carabello
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003402:Creatine Kinase / Q000378:metabolism; D004699:Endocardium / Q000293:injuries / Q000503:physiopathology / Q000648:ultrastructure; D006335:Heart Injuries / Q000209:etiology*; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D013552:Swine; D013617:Tachycardia, Supraventricular / Q000150:complications* / Q000473:pathology / Q000503:physiopathology
chemical_list: D003402:Creatine Kinase