[Changes of creatine phosphokinase and malondialdehyde in the serum and clinical use of large doses of vitamin C following open heart surgery].
The protective effect of a large dose Vit. C on ischemic myocardium was studied on 10 patients who underwent open heart operation and received 250 mg/kg Vit. C before the start of ECC (Group II). Another 10 similar patients receiving no Vit. C served as a control (Group I). Blood samples were taken from the brachial artery at different time intervals for determination of CPK-MB and MDA in both groups. Considerable increases of serum CPK-MB and MDA in both group I and II were noted. The differences of CPK-MB and MDA concentration between Group I and II were highly significant from 2 to 12 hours postoperatively. The effect of Vit. C in the reduction of the release of CPK-MB and MDA after open heart operation was attributed to its action as an oxygen free radical scavenger, thus decreasing the peroxidation of the lipids present in the cell membrane.
Li
C C
CC
Second Affiliated Hospital, Xi-an Medical University.
D000293:Adolescent; D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D002648:Child; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000097:blood / Q000601:surgery; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*
D007527:Isoenzymes; D008314:Malonates; D008315:Malondialdehyde; D003402:Creatine Kinase; D001205:Ascorbic Acid