Quantitative evaluation of the stability and delivery of interleukin-1B by infusion.
The stability and delivery of IL-1 beta has been characterized in a polypropylene based syringe pump infusion system and in polyvinyl chloride based infusion bags, at concentrations ranging from 100 ng/mL to 1 microgram/mL. At higher concentrations (1 microgram/mL), minimal drug loss was observed in both systems. At low doses (100 ng/mL) in the syringe-pump system, the addition of 1% human serum albumin was necessary to prevent significant drug absorption to the polypropylene drug reservoir.
Visor
G C
GC
Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California.
Tsai
K P
KP
Duffy
J
J
Miller
M D
MD
Calderwood
T
T
Knepp
V M
VM
D000327:Adsorption; D004355:Drug Stability; D004867:Equipment Design; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous / Q000295:instrumentation / Q000379:methods; D007375:Interleukin-1 / Q000008:administration & dosage*; D053583:Interleukin-1beta; D008954:Models, Biological; D010446:Peptide Fragments / Q000008:administration & dosage*; D011126:Polypropylenes; D013594:Syringes
D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; D011126:Polypropylenes; C056932:interleukin 1beta (193-195)