title: Evaluation of indicators of erythropoiesis stimulated by recombinant human erythropoietin in renal anemia.
abstract: Recombinant human erythropoietin (rh-EPO) was administered to 11 anemic children with end-stage renal disease who were undergoing hemodialysis. Hematocrit (Hct), absolute reticulocyte count (retics), creatine concentration of red cells and erythrocyte density test (EDT) were chosen as indicators of rh-EPO effect on erythropoiesis. In the present report the first 9 weeks shall be presented in which all patients received an identical dosage of rh-EPO per kg body weight. The pre-EPO values of retics, creatine and EDT varied considerably. In 10 patients the Hct increased to 0.30 after 9 weeks of rh-EPO treatment. Retics and creatine rose in all cases above the normal range, rates of increase and maximal values differed. Retics, creatine and EDT respond faster to rh-EPO than Hct. Retics and creatine seem to be equally good indicators of rh-EPO stimulated erythropoiesis. The EDT showed an increase only up to the 4th week.
authors.affiliation: Children's Hospital, Berlin, GDR.
authors.forename: G
authors.initials: G
authors.lastname: Schmidt
authors.forename: G
authors.initials: G
authors.lastname: Stamminger
authors.forename: A
authors.initials: A
authors.lastname: Daniel
authors.forename: J
authors.initials: J
authors.lastname: Gross
authors.forename: I
authors.initials: I
authors.lastname: Syllm-Rapoport
authors.forename: A
authors.initials: A
authors.lastname: Lun
authors.forename: K
authors.initials: K
authors.lastname: Zoellner
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000150:complications / Q000378:metabolism*; D002648:Child; D003401:Creatine / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D006435:Renal Dialysis
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D003401:Creatine