title: Multicentric reticulohistiocytosis in a patient with malignant melanoma: a response to cyclophosphamide and a unique cutaneous feature.
abstract: We describe a patient with multicentric reticulohistiocytosis and a history of malignant melanoma. His widely disseminated disease did not affect the site of surgical removal of the malignant melanoma nor the donor site of a skin graft. The multicentric reticulohistiocytosis progressed while the patient was taking nonsteroidal antiinflammatory agents, but showed significant response during a 10-month course of cyclophosphamide. While he was taking the cyclophosphamide, however, his melanoma recurred, and the patient subsequently died.
authors.affiliation: Department of Internal Medicie, Creighton University School of Medicine, Omaha, Nebraska 68131.
authors.forename: J G
authors.initials: JG
authors.lastname: Kenik
authors.forename: F
authors.initials: F
authors.lastname: Fok
authors.forename: C J
authors.initials: CJ
authors.lastname: Huerter
authors.forename: J A
authors.initials: JA
authors.lastname: Hurley
authors.forename: J F
authors.initials: JF
authors.lastname: Stanosheck
mesh_terms: D003520:Cyclophosphamide / Q000627:therapeutic use*; D015614:Histiocytosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications*; D008875:Middle Aged; D012156:Reticulocytes / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications*
chemical_list: D003520:Cyclophosphamide