title: The effect of ACE inhibition on myocardial energy metabolism.
abstract: There are several indications that the oxygen supply to the myocardium is inadequate in chronic heart failure. This is due to an increased intramyocardial vascular resistance, elevated filling pressures, and a shortened diastolic perfusion time. In parallel, the myocardial oxygen demand is heightened due to elevated wall stress, heart rate and contractility. This imbalance between myocardial oxygen supply and demand might be the cause of the adaptive metabolic changes seen in severe chronic heart failure. We showed increased LDH 5, decreased LDH 1 and increased ADP/ATP-carrier concentration in the myocardium from patients with chronic heart failure. After ACE-inhibitor treatment in 33 patients with chronic heart failure, LDH 1 increased from 38.7 +/- 6.7% to 42.3 +/- 5.5% (P less than 0.005) paralleled by a decrease in LDH 5 from 20.8 +/- 7.0% to 15.8 +/- 4.7% (P less than 0.001). The ADP/ATP-carrier concentration also decreased significantly within the normal range. This shift in the LDH isoenzyme pattern and decrease in the ADP/ATP-concentration can be interpreted as an indication for an improvement of myocardial energy balance in chronic heart failure under ACE-inhibitor therapy. This might help interrupt the self-perpetuation of chronic heart failure which is partially caused by a progressive subendocardial perfusion deficit.
authors.affiliation: Medizinische Klinik and Poliklinik B, Universität Düsseldorf, F.R.G.
authors.forename: H P
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: G
authors.initials: G
authors.lastname: Ullrich
authors.forename: M
authors.initials: M
authors.lastname: Schindler
authors.forename: K
authors.initials: K
authors.lastname: Schulze
authors.forename: B E
authors.initials: BE
authors.lastname: Strauer
mesh_terms: D002303:Cardiac Output, Low / Q000503:physiopathology; D002908:Chronic Disease; D004656:Enalapril / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007525:Isoelectric Focusing; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D004656:Enalapril; D000226:Mitochondrial ADP, ATP Translocases; D007770:L-Lactate Dehydrogenase; D005947:Glucose