title: Small intestinal injury and parasitic diseases in AIDS.
abstract: OBJECTIVE
  To examine jejunal biopsies from patients with the acquired immunodeficiency syndrome (AIDS), chronic diarrhea, and weight loss, and to correlate the presence of small intestinal injury with pathogens, histopathologic changes, and absorption.
  
  
  METHODS
  Prospective analysis of jejunal biopsies from 43 patients with AIDS, 10 patients with AIDS-related complex, and 6 heterosexual control volunteers. The biopsies were examined for pathogens; electron microscopy was used in 22 patients. The results of quantitative histologic measurements were correlated with histopathologic features and D-xylose absorption.
  
  
  METHODS
  A university-affiliated teaching hospital with many AIDS patients of varying demographic characteristics.
  
  
  RESULTS
  Jejunal biopsies in 62% of the patients with AIDS had partial villus atrophy with or without crypt hyperplasia unlike those of controls, a result implying small intestinal injury. Small intestinal injury was associated with lymphoplasmacytic infiltration and cytopathic change of the villus epithelium. Light and electron microscopic examination detected cryptosporidia or microsporidia in 19 of 27 patients with small intestinal injury. The presence of these parasites was associated with significantly diminished D-xylose absorption when compared with absorption in controls or in patients with AIDS, diarrhea, weight loss, and no parasites.
  
  
  CONCLUSIONS
  A significant proportion of patients with AIDS with severe small intestinal injury have enterocyte infections. Like cryptosporidiosis, intestinal microsporidiosis may be an important cause of enteropathy in patients with AIDS.
authors.affiliation: St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: D P
authors.initials: DP
authors.lastname: Kotler
authors.forename: A
authors.initials: A
authors.lastname: Francisco
authors.forename: F
authors.initials: F
authors.lastname: Clayton
authors.forename: J V
authors.initials: JV
authors.lastname: Scholes
authors.forename: J M
authors.initials: JM
authors.lastname: Orenstein
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D001284:Atrophy / Q000209:etiology; D003967:Diarrhea / Q000150:complications; D006801:Humans; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000209:etiology / Q000473:pathology; D007411:Intestinal Diseases, Parasitic / Q000150:complications* / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000469:parasitology / Q000473:pathology*; D007583:Jejunum / Q000473:pathology; D015995:Prevalence; D015431:Weight Loss