Amphetamine lowers extracellular GABA concentration in the ventral pallidum.
In vivo dialysis was performed in the ventral pallidum of the conscious rat, and extracellular levels of gamma-aminobutyric acid (GABA) measured. Forty minutes following peripheral administration of amphetamine (2.0 mg/kg, s.c.) the extracellular concentration of GABA was significantly reduced, in parallel with a significant elevation in motor activity. These data indicate that a decline in GABA transmission in the ventral pallidum may be important in the initiation of amphetamine-induced motor activity.
Bourdelais
A
A
Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520.
Kalivas
P W
PW
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D000661:Amphetamine