title: [Benzalkonium chloride for vaginal contraception--the vaginal sponge].
abstract: From March 1986 to December 1987, a vaginal contraceptive, not yet commercially available in Germany, was studied in 56 women. The substance benzalconium chloride (BZC) was contained in vaginal sponges (n = 46), pessaries (n = 4) and cream (n = 6) at a dose rate of 1.18%. BZC is a surfactant of the ammonium series that ruptures the spermatozoal membrane. It is also a powerful bactericide and viricide. The advantages of the vaginal sponge (intercourse is safe immediately after insertion for the next 24 h and for multiple intercourses) made it pleasant for the women. The rate of transitory local side effects (16%) was acceptable. The vaginal contraception did not interfere with the sexual life. In 645 months of use 10 pregnancies occurred of which 9 happened with the sponge (PI 20.3). Its fixation before the cervix and the release of the spermicide is not reliable enough, so that we cannot recommend the sponge as a safe vaginal contraceptive.
authors.affiliation: Abteilung für Gynäkologische Endokrinologie der Universitäts, Frauenklinik Heidelberg.
authors.forename: U
authors.initials: U
authors.lastname: Meyer
authors.forename: I
authors.initials: I
authors.lastname: Gerhard
authors.forename: B
authors.initials: B
authors.lastname: Runnebaum
mesh_terms: D000328:Adult; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D003274:Contraceptive Devices, Female; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D013089:Spermatocidal Agents; D013630:Tampons, Surgical
chemical_list: D001548:Benzalkonium Compounds; D013089:Spermatocidal Agents
vernacular_title: Benzalkonium-Chlorid zur vaginalen Kontrazeption-der Scheidenschwamm.