Suppression of urushiol-induced delayed-type hypersensitivity responses in mice with serum IgG immunoglobulin from human hyposensitized donors.
Serum IgG immunoglobulin fractions from human subjects hyposensitized to poison ivy/oak by oral administration of urushiol suppressed the induction of delayed-type hypersensitivity (DTH) responses in mice to this hapten. This suppressive activity was hapten specific because it did not modify DTH responses to dinitrofluorobenzene (DNFB). Absorption of human serum with lymph node cells from urushiolsensitized but not DNFB-sensitized mice removed the suppressive activity, suggesting that anti-idiotypic antibodies reacting with T-cell receptors are involved.
Stampf
J L
JL
Division of Toxicology, University of California, San Francisco 94143-0536.
Castagnoli
N
N
Epstein
W
W
Baldwin
R W
RW
Byers
V
V
D000818:Animals; D002396:Catechols / Q000276:immunology*; D003864:Depression, Chemical; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D007074:Immunoglobulin G / Q000494:pharmacology; D008198:Lymph Nodes / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C
D002396:Catechols; D007074:Immunoglobulin G; C003747:urushiol