title: Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs.
abstract: Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10-15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10-25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls.
authors.affiliation: Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN.
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: G D
authors.initials: GD
authors.lastname: Bottoms
authors.forename: S M
authors.initials: SM
authors.lastname: Gaafar
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000662:veterinary*; D001196:Ascariasis / Q000097:blood / Q000150:complications / Q000662:veterinary*; D002448:Cell Adhesion / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology; D001068:Feeding and Eating Disorders / Q000662:veterinary*; D005260:Female; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D003609:Dactinomycin