Enhanced fecal excretion of bile acids by a new anion-exchange resin possessing a spacer arm in rats.
The effect of a new polystyrene-based, strongly basic, anion-exchange resin possessing an omega-oxobutyl chain as a spacer arm on the fecal bile acid excretion was investigated in rats and compared with that of Dowex 1-X2, chemically equivalent to cholestyramine. The new resin did produce a significant rise in the total fecal bile acid excretion with its ingestion for a period of 4 weeks. Its promoting activity proved to be 2.0- and 1.8-fold more potent than that of Dowex 1-X2 at the 3rd and 4th week, respectively. These results suggest that the introduction of a spacer arm between the polymer backbone and a functional group would lead to an improvement in the in vivo adsorptive efficiency of the resin.
Honda
Y
Y
Department of Pharmacy, Kumamoto University Hospital, Japan.
Nakano
M
M
Haratake
M
M
Sugii
A
A
D000818:Animals; D000837:Anion Exchange Resins / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002082:Butylamines / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D005243:Feces / Q000032:analysis*; D007475:Ion Exchange Resins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012117:Resins, Synthetic
D000837:Anion Exchange Resins; D001647:Bile Acids and Salts; D002082:Butylamines; D007475:Ion Exchange Resins; D012117:Resins, Synthetic; C065322:SP-3 resin; C027972:Dowex; D002784:Cholesterol