Kynurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats.
The effects of the excitatory amino acid receptor antagonist, kynurenate, were investigated in spontaneously hypertensive rats after middle cerebral artery occlusion. Kynurenate did not significantly modify either the infarct volume, measured 48 h after occlusion, or the neurological score. The absence of a neuroprotective effect of kynurenate in this study, which contrasts with results in normotensive rats, is suggested to be due to impaired collateral circulation in spontaneously hypertensive rats.
Roussel
S
S
Laboratoire de Physiologie et Physiopathologie cérébrovasculaire, U. 182 I.N.S.E.R.M., Paris, France.
Pinard
E
E
Seylaz
J
J
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000473:pathology; D002536:Cerebral Arteries / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D002544:Cerebral Infarction / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D007736:Kynurenic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D007736:Kynurenic Acid