title: [Bone marrow necrosis in thymic T cell lymphoma].
abstract: A 29 year-old male patient was admitted because of exertional dyspnea, due to the pleural effusion on chest X-P on June 18 of 1988. On admission, enlargement of left supraclavicular and mediastinal lymph nodes were found. Cytological studies of pleural exudate cells showed the proliferation of atypical lymphoid cells with a few eosinophiles. Surface markers of the tumor cells were just positive for both CD5 and CD38, thus indicated that they resided as early thymocyte along T cell differentiation. Moreover, according to Southern blotting analysis, these DNA's showed rearrangement of TCR-beta genes. Based on these results, he was diagnosed to be suffered from thymic T cell lymphoma. Bone marrow biopsy on left posterior iliac bone showed tumor necrosis owing to extensive tumor which were diffusely infiltrated among collagen fibers with reticulin fibrosis. He was treated with aggressive combination chemotherapy but achieved no remission and died of cerebral vascular bleeding on Jan. 7, 1989.
authors.affiliation: Third Department of Internal Medicine, Hokkaido University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Kunieda
authors.forename: M
authors.initials: M
authors.lastname: Okabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kunita
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: M
authors.initials: M
authors.lastname: Akiba
authors.forename: Y
authors.initials: Y
authors.lastname: Oikawa
authors.forename: M
authors.initials: M
authors.lastname: Oita
authors.forename: M
authors.initials: M
authors.lastname: Ogasawara
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Morioka
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D009336:Necrosis; D013601:T-Lymphocytes