Monoiodo-D-tyrosine, an artificial amino acid radiopharmaceutical for selective measurement of membrane amino acid transport in the pancreas.
Using 11C-labeled natural amino acids, the functional diagnosis of tissue metabolism has been actively studied. Our interest has been focused on developing a clinically available 123I-labeled artificial amino acid with a single metabolic function. For this study, [123I]3-iodo-D-tyrosine ([123I]D-MIT) was selected. In vitro and in vivo studies using 125I-labeled D-MIT indicated that it showed a high pancreatic accumulation, selective affinity for membrane active transport systems, and was stable against enzymatic deiodination. A canine scintigraphic study using 123I-labeled D-MIT and kinetic analysis showed that it behaved as an "artificial amino acid" radiopharmaceutical with selective membrane amino acid transport affinity in the pancreas.
Kawai
K
K
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Fujibayashi
Y
Y
Saji
H
H
Konishi
J
J
Kubodera
A
A
Yokoyama
A
A
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D004285:Dogs; D004355:Drug Stability; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D007470:Monoiodotyrosine / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010179:Pancreas / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D014018:Tissue Distribution
D000596:Amino Acids; D007457:Iodine Radioisotopes; D007470:Monoiodotyrosine