title: Hormonal basis of variation in oestrous cyclicity in selected strains of mice.
abstract: Reproductive hormone secretion and ovarian LH receptor content were studied during the oestrous cycle of mice that differed in fertility after genetic selection. Strain variation in the secretory pattern of progesterone was observed along with differences in the timing and magnitude of prolactin release. Scatchard analysis showed similar affinities of the LH receptor for hCG in strains with increased or decreased reproductive performance, with a single order of binding sites during both pro-oestrus and dioestrus. The number of unoccupied LH receptors during pro-oestrus was greatest in mice with increased reproductive performance. These results provide evidence that trait selection can change gonadotrophin receptor concentration and the dynamics of hormone secretion during the oestrous cycle of the mouse.
authors.affiliation: Department of Animal Physiology, University of California, Davis 95616.
authors.forename: D D
authors.initials: DD
authors.lastname: DeLeon
authors.forename: M B
authors.initials: MB
authors.lastname: Zelinski-Wooten
authors.forename: M S
authors.initials: MS
authors.lastname: Barkley
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004971:Estrus / Q000378:metabolism*; D005260:Female; D005298:Fertility / Q000235:genetics / Q000502:physiology*; D005838:Genotype; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D010053:Ovary / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D011974:Receptors, LH / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D011974:Receptors, LH; D011374:Progesterone; D011388:Prolactin