Myasthenia gravis after allogeneic bone marrow transplantation: report of a new case and pathogenetic considerations.
A 21-year-old caucasian man with T acute lymphoblastic leukemia underwent a bone marrow transplantation (BMT) and developed classic myasthenia gravis (MG) 46 months later. The association of almost all published cases with HLA B35 is discussed, as are the clinical aspects suggesting that BMT survivors are at risk for developing MG as part of the spectrum of chronic graft-versus-host disease.
Grau
J M
JM
Muscle Research Unit, Hospital Clinic i Provincial, Barcelona, Spain.
Casademont
J
J
Monforte
R
R
Marín
P
P
Grañena
A
A
Rozman
C
C
Urbano-Márquez
A
A
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D014184:Transplantation, Homologous / Q000009:adverse effects*