Lactational variation and relationship to postnatal growth of insulin-like growth factor-I in mammary secretions from genetically diverse sows.
Mammary secretions obtained from four groups of sows at parturition and on days 7, 14 and 21 of lactation were defatted and assayed for total protein and insulin-like growth factor-I (IGF-I). Sows (n = 57) represented two breeds (Landrace and Duroc) and two genetic lines (selected for differences in sow productivity index, SPI) within each breed. Colostrum of Duroc sows was 4-6 fold and 30-60 fold greater in protein (P less than .001) and IGF-I (P less than .001) concentrations, respectively, than the corresponding day 7 milk from these sows. In contrast, the colostrum of Landrace sows was 2-3 fold and 30-50 fold greater in protein (P less than .001) and IGF-I (P less than .001) concentrations, respectively, than the corresponding day 7 milk. The IGF-I content in milk from Duroc sows did not differ among days 7, 14 and 21 of lactation, whereas the IGF-I content of day 7 milk from Landrace sows exceeded those for the corresponding 14 day and 21 day secretion (P less than .05). IGF-I concentration in days 14 and 21 milk was higher in Duroc (P less than .001 respectively) than Landrace sows. No significant differences in total protein or IGF-I content of mammary secretions were observed between the selected and control lines within each breed.(ABSTRACT TRUNCATED AT 250 WORDS)
Simmen
F A
FA
Laboratory of Molecular Biology, Ohio Agricultural Research and Development Center, Ohio State University, Wooster 44691-6900.
Whang
K Y
KY
Simmen
R C
RC
Peterson
G A
GA
Bishop
M D
MD
Irvin
K M
KM
D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development*; D001947:Breeding; D003126:Colostrum / Q000032:analysis; D005260:Female; D005838:Genotype; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D007774:Lactation / Q000235:genetics / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000032:analysis; D008894:Milk Proteins / Q000032:analysis; D011247:Pregnancy; D013002:Somatomedins / Q000378:metabolism*; D013552:Swine / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D008894:Milk Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I