[The effect of a 3-hydroxypyridine-class antioxidant on disorders of the microcirculatory system in experimental dyslipoproteinemia and its alimentary correction].
The effect of antioxidant (AO) of the 3-hydroxypyridin class on microcirculatory system (MC) disorders of rabbits with dyslipoproteinemia (DLP) and its alimentary correction (the standard ration--9 months) was studied. Aorta, the intestinal mesentery microcirculatory bed, the microvessels adrenergic innervation, erythrocyte morphology were examined. The various lipoprotein fractions and lipid peroxidation (LP) products were studied in venous blood. After AO including into atherogenic diet (ATD) the lipid homeostasis disorders, the LP activation, MC disturbances, anomalous erythrocyte form appearance and atherosclerosis changes in aorta were less pronounced. Under the AO influence when DLP was corrected the initial level of lipid metabolism and LP restored, the MC disorders and the atherosclerosis changes in aorta regressed in a shorter period of time. The interrelation was observed between the DLP level, the structural and functional MC disorders and the extent of aorta atherosclerosis. Thus, DLP and LP correction at the early stages of pathological process can lead to the disappearance of MC disorders, what seems important for the prevention of atherosclerosis. The role of the LP activation in MC disorders in DLP and mexidol effect on them, especially in complex with DLP correction were evaluated.
Klimenko
E D
ED
Kobozeva
L P
LP
Michunskaia
A B
AB
Zolotov
N N
NN
Khabarina
I Iu
IIu
Pozdniakov
O M
OM
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D006951:Hyperlipoproteinemias / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D008643:Mesentery / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D000975:Antioxidants; D008055:Lipids; D011725:Pyridines; C023500:3-hydroxypyridine
Vliianie antioksidanta iz klassa 3-oksipiridina na narusheniia v mikrotsirkuliatornoĭ sisteme pri éksperimental'noĭ dislipoproteidemii i ee alimentarnoĭ korrektsii.