A defect in the central component of the immune system--hypothalamic-pituitary-adrenal axis feedback loop is associated with susceptibility to experimental arthritis and other inflammatory diseases.
Sternberg
E M
EM
Clinical Neurosciences Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892.
Wilder
R L
RL
Gold
P W
PW
Chrousos
G P
GP
D000818:Animals; D001168:Arthritis / Q000209:etiology*; D005246:Feedback; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007249:Inflammation / Q000209:etiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew