Role of cholecystokinin in bombesin- and meal-stimulated pancreatic polypeptide secretion in dogs.
This study was undertaken to delineate the role of cholecystokinin (CCK) in bombesin- and meal-stimulated pancreatic polypeptide (PP) secretion in seven conscious dogs by studying: (1) the stimulatory effect of similar plasma levels of CCK induced by a meal and infusions of bombesin and the synthetic CCK analog cerulein on plasma PP, and (2) the inhibition of PP secretion by the CCK-receptor antagonist CR-1409 during these three stimuli. The stimulation of PP secretion during bombesin (11.0 +/- 1.6 nM/hr) and after the meal (8.9 +/- 2.0 nM/hr) were significantly (P less than 0.05) greater than during infusion of the CCK analog cerulein (2.7 +/- 0.4 nM/hr). CR-1409 significantly inhibited the bombesin- and meal-stimulated PP secretion to 2.0 +/- 0.4 nM/hr (81%; P less than 0.05) and 3.1 +/- 1.2 nM/hr (47%; P less than 0.05), respectively, while the cerulein-stimulated PP release was almost abolished to 0.2 +/- 0.1 nM/hr (93%; P less than 0.05) by the drug. These findings point to an important role for CCK in the regulation of bombesin- and meal-stimulated PP secretion.
Jansen
J B
JB
Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
de Jong
A J
AJ
Singer
M V
MV
Niebel
W
W
Rovati
L C
LC
Lamers
C B
CB
D000818:Animals; D001839:Bombesin; D002108:Ceruletide; D002766:Cholecystokinin / Q000502:physiology*; D004285:Dogs; D005260:Female; D005502:Food; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D011377:Proglumide / Q000031:analogs & derivatives; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors
D011949:Receptors, Cholecystokinin; D010191:Pancreatic Polypeptide; D002108:Ceruletide; D002766:Cholecystokinin; D011377:Proglumide; C048181:lorglumide; D001839:Bombesin