The anthelmintic activity of a novel organic arsenical, R7/45, upon Brugia pahangi in Meriones unguiculatus.
The new organic arsenical R7/45 is a rapidly acting and very potent anthelmintic against adult Brugia pahangi in jirds. Against adult worms implanted into the peritoneal cavity 5 subcutaneous (SC) injections at 2.5 mg/kg of R7/45 killed 100% of adult worms. A single dose SC of 20 mg/kg was 100% effective and 10 mg/kg 76% effective against adult worms. When jirds were autopsied at different times after treatment at 20 mg/kg SC 89% of worms were dead within three days. R7/45 was not active when given by stomach intubation. Pretreatment of jirds with R7/45 had no effect on adult worms subsequently implanted into jirds. R7/45 was highly active against third and fourth stage larvae of B. pahangi in jirds.
Denham
D A
DA
London School of Hygiene and Tropical Medicine, England.
Midwinter
I T
IT
Friedheim
E A
EA
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001152:Arsenicals / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002009:Brugia / Q000187:drug effects; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005849:Gerbillinae; D007279:Injections, Subcutaneous; D010529:Peritoneal Cavity / Q000469:parasitology; D013997:Time Factors
D000871:Anthelmintics; D001152:Arsenicals; D005369:Filaricides; C065461:R 7-45