New triterpenes from a Chinese medicine, goreishi.
Besides serratagenic acid, three new ursane-type triterpenes, named goreishic acids I (1), II (2), and III (3), were isolated from a Chinese medicine, Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). The structures of 1, 2 and 3 were respectively determined as 2 alpha,3 beta-dihydroxyursa-12,18-dien-28-oic acid, 2 alpha,3 beta-dihydroxy-23-norursa-12,18-dien-28-oic acid and 2 alpha,3 beta-dihydroxy-24-norursa-12,18-dien-28-oic acid on the basis of spectroscopic evidence.
Numata
A
A
Osaka University of Pharmaceutical Sciences, Matsubara, Japan.
Takahashi
C
C
Miyamoto
T
T
Yoneda
M
M
Yang
P M
PM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000494:pharmacology; D051379:Mice; D014315:Triterpenes / Q000032:analysis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C064858:goreishic acid I; C064857:goreishic acid II; C064859:serratagenic acid