title: [The correction with hepatic protectors of structural metabolic disorders in the liver in D-galactosamine poisoning].
abstract: The hepatoprotective agents silybinin, essentiale and eplir (the complex of phospholipids and caratinoids from the mud) prevent in D-galactosamine-induced intoxication of rats the development of hepatitis, hepatocyte necrosis, a decrease in hepatocytes of the activity of the enzymes of mitochondria and endoplasmic reticulum, labilization of lysosomes. These drugs stimulate D-galactosamine-suppressed antitoxic function of the liver: they increase the contents of RNA, cytochromes P-450, b5, the activity of amidopyrine-D-demethylase, hydroxylases of hexobarbital and aniline, improve the activity of the respiratory chain of microsomes, counteract inactivation of cytochrome P-450 into cytochrome P-420. Essentiale and eplir activate conjugation of xenobiotics with reduced glutathione.
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovskiĭ
authors.forename: I M
authors.initials: IM
authors.lastname: Sedykh
mesh_terms: D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use*; D005688:Galactosamine / Q000506:poisoning*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009094:Mud Therapy; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010743:Phospholipids / Q000627:therapeutic use*; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use*
chemical_list: D000931:Antidotes; D004338:Drug Combinations; D005419:Flavonoids; D010713:Phosphatidylcholines; D010743:Phospholipids; D012838:Silymarin; C064845:eplir; C011246:essential 303 forte; D002338:Carotenoids; D005688:Galactosamine
vernacular_title: Korrektsiia gepatoprotektorami strukturno-metabolicheskikh narusheniĭ v pecheni pri intoksikatsii D-galaktozaminom.