Acute effect of parathyroid hormone-(1-34) fragment on blood pressure in rats fed a low calcium diet.
1. Acute effects of human PTH-(1-34) fragment on blood pressure were examined in rats fed a low or normal calcium diet. 2. Plasma biochemistry showed that a low calcium diet evoked hyperparathyroidism as well as hypocalcemia in rats. 3. Subcutaneous administration of human PTH-(1-34) caused a significant decrease in tail-cuff systolic blood pressure in rats fed a normal calcium diet, but not in rats fed a low calcium diet. 4. Intravenous administration of human PTH-(1-34) reduced the arterial blood pressure in rats, dose-dependently. The reduction of blood pressure was more pronounced in rats fed a normal calcium diet than that in the rats fed a low calcium diet. 5. It is suggested that the hypotensive action of human PTH-(1-34) was more pronounced in the rats fed a normal diet than in the rats fed a low calcium diet, and that PTH has different cardiovascular consequences under chronic hyperparathyroidism and/or hypocalcemia.
Togari
A
A
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Shintani
S
S
Arai
M
M
Matsumoto
S
S
Nagatsu
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000097:blood / Q000172:deficiency; D002136:Calcium, Dietary / Q000008:administration & dosage*; D006961:Hyperparathyroidism / Q000503:physiopathology; D006996:Hypocalcemia / Q000503:physiopathology; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D019379:Teriparatide; D014664:Vasodilation / Q000187:drug effects
D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019379:Teriparatide; D002118:Calcium