Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
Short-term cultures of two myxoid liposarcomas and two mixed-type (myxoid and round cell) liposarcomas were cytogenetically analyzed. A t(12;16)(q13;p11) was present in three tumors, whereas the fourth had an unbalanced 12;16-translocation with breaks in 12q13 and 12q22, with loss of the 12q13-q22 segment, and in 16p11. In the two mixed liposarcomas, the breakpoints could be determined at subband level to 12q13.3 and 16p11.2.
Eneroth
M
M
Department of Clinical Genetics, Lund University Hospital, Sweden.
Mandahl
N
N
Heim
S
S
Willén
H
H
Rydholm
A
A
Alberts
K A
KA
Mitelman
F
F
D000328:Adult; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D005819:Genetic Markers