Improvement of decreased natural killer cell activity in cervical cancer patients by active lipids (AL 721).
In the present study we observed the absolute number of NK cells and the NK activity in 10 patients with cervical cancer. NK activity was determined before and after stimulation with Active Lipids. We reported a significant decrease of basal NK activity, but after AL stimulation NK activity was increased with statistical significance. Therefore our findings show that the reduction of NK activity in neoplastic patients is not an irreversible phenomenon since it can be restored by "in vitro" AL administration. This is important for the adoptive immunotherapy by which we could give LAK cells to the patients.
Garzetti
G G
GG
Department of Obstetrics and Gynaecology, University of Ancona, Italy.
Cignitti
M
M
Marchegiani
F
F
Provinciali
M
M
Zaia
A M
AM
Fabris
N
N
Pieri
C
C
Romanini
C
C
D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005989:Glycerides / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010714:Phosphatidylethanolamines / Q000494:pharmacology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D004338:Drug Combinations; D005989:Glycerides; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; C046637:neutral lipid, phosphatidylcholine, phosphatidylethanolamine drug combination