1,8-Dinitropyrene: comparative mutagenicity in Chinese hamster V79 and CHO cells.
1,8-Dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary data indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensitivity of the two cell lines to the mutagenicity of 1,8-DNP.
O'Donovan
M R
MR
Boots Pharmaceuticals Research Department, Nottingham, UK.
D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D002460:Cell Line / Q000187:drug effects* / Q000201:enzymology; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens; D011721:Pyrenes / Q000633:toxicity*
D009153:Mutagens; D011721:Pyrenes; C033310:1,8-dinitropyrene; D001191:Arylamine N-Acetyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase