[The central effects of a steroid alkaloid, Buxaminol-E, in conscious cats].
Buxaminol-E injected i.v. to conscious cats evoked hypothermia, tachypnoe, anorexia, salivation, defecation, decrease of spontaneous activity and sensitivity to painful stimulus and agitation during its administration. The above mentioned effects of B--E, with the exception of the antinociceptive action which was not examined and of the initial excitation, were observed also after intracerebroventricular (i.c.v.) administration of B--E, and they were depressed by atropine administered i.c.v. Our findings suggest a central cholinergic action of B--E in conscious cats. Paroxysmal tonic-clonic convulsions and circling observed only after i.c.v. administration of B--E and piloerection, ataxia and urination were not inhibited by atropine administered i.c.v.
Lukovic
L
L
Ustav experimentálnej farmakológie CFV SAV, Dúbravská, Bratislava.
Machová
J
J
D000470:Alkaloids / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects*; D003243:Consciousness; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009649:Norpregnadienes / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity*
D000470:Alkaloids; D009649:Norpregnadienes; C065119:buxaminol E; D001285:Atropine
Centrálne úcinky stereoidného alkaloidu Buxaminolu-E u bdelých maciek.