title: Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains.
abstract: By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration greater than or equal to 8 mg/l) or resistant (minimal inhibiting concentration greater than or equal to 64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam-mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations.
authors.affiliation: Unit of Antibiotic Research, Institute Pasteur of Brabant, Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Vanhoof
authors.forename: J M
authors.initials: JM
authors.lastname: Hubrechts
authors.forename: H J
authors.initials: HJ
authors.lastname: Nyssen
authors.forename: E
authors.initials: E
authors.lastname: Nulens
authors.forename: J
authors.initials: J
authors.lastname: Leger
authors.forename: N
authors.initials: N
authors.lastname: de Schepper
authors.forename: E
authors.initials: E
authors.lastname: Kupperberg
authors.forename: M L
authors.initials: ML
authors.lastname: Couvreur
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015310:Cefotiam / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D015310:Cefotiam