[The contraceptive activity of triterpene glycosides--the total sum of holotoxins A1 and B1 and holothurin A in an experiment].
The sum of triterpene glycosides of the Far Eastern holothurian Stichopus japonicus Selenka (holotoxins A1 and B1) possesses the contraceptive activity. Glycoside holoturin A of the tropical holothurian Holoturia atra lacks these properties. The action of the sum of holotoxins is based on the estrogenic activity which was demonstrated both in the uterotropic and vaginotropic tests. The drug under study suppresses ovulation and stimulates the contractile activity of the uterus.
Mats
M N
MN
Korkhov
V V
VV
Stepanov
V R
VR
Kupera
E V
EV
Oleĭnikova
G K
GK
Anisimov
M M
MM
D000818:Animals; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004447:Echinodermata; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006697:Holothurin / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D012616:Sea Cucumbers; D013737:Testis / Q000187:drug effects; D014315:Triterpenes / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D003281:Contraceptives, Postcoital; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; D006697:Holothurin; C034723:holothurin A; C001883:stichoposide
Kontratseptivnaia aktivnost' triterpenovykh glikozidov--summy golotoksina A1 i B1 i goloturina A v éksperimente.