Methyl chloride transferase: a carbocation route for biosynthesis of halometabolites.
Enzymatic synthesis of methyl halides through an S-adenosyl methionine transfer mechanism has been detected in cell extracts of Phellinus promaceus (a white rot fungus), Endocladia muricata (a marine red algae), and Mesembryanthemum crystallium (ice plant). This mechanism represents a novel pathway for the formation of halometabolites. The Michaelis constants for chloride and bromide ion and for S-adenosyl methionine in the reaction have been determined for the enzyme from E. muricata. A recent survey of marine algae indicates that there may be a broad distribution of this enzyme among marine algae.
Wuosmaa
A M
AM
Roger Adams Laboratory, Department of Biochemistry, University of Illinois, Urbana 61801.
Hager
L P
LP
D001487:Basidiomycota / Q000201:enzymology; D001965:Bromides / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007454:Iodides / Q000378:metabolism; D008737:Methyl Chloride / Q000378:metabolism*; D008745:Methylation; D008780:Methyltransferases / Q000302:isolation & purification / Q000378:metabolism*; D008970:Molecular Weight; D010944:Plants / Q000201:enzymology; D000461:Rhodophyta / Q000201:enzymology*; D014871:Water Microbiology
D001965:Bromides; D002712:Chlorides; D007454:Iodides; D008737:Methyl Chloride; D008780:Methyltransferases; C064965:methyl chloride transferase