Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine.
Serum levels of 7 alpha-hydroxycholesterol (7 alpha (OH)C) were found to increase considerably in hypercholesterolemic patients treated with cholestyramine. After 3-5 days, the normal level, which is in the range of 0.04 mg/l, rose to 1 mg/l. When the treatment was stopped it decreased rapidly with a half-life analogous to that of LDLs. This phenomenon was also observed in non-hypercholesterolemic humans. More than 75% of 7 alpha (OH)C is carried in blood by the LDLs.
Bascoul
J
J
INSERM U.58, Montpellier, France.
Gozé
C
C
Domergue
N
N
Crastes de Paulet
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006888:Hydroxycholesterols / Q000097:blood*; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000188:drug therapy; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged
D006888:Hydroxycholesterols; D008077:Lipoproteins, LDL; D002792:Cholestyramine Resin; C011724:cholest-5-en-3 beta,7 alpha-diol