Effects of dihydroergotoxine on some dopamine-related behaviors in rats.
1. The effects of dihydroergotoxine on open-field behavior, apomorphine-induced stereotype and haloperidol-induced catalepsy were studied quantitatively in rats. 2. Dihydroergotoxine decreased the open-field behavior of rats, in a dose-dependent manner; this effect remained at least for 8 hr. 3. Dihydroergotoxine (10.0 mg/kg) caused a 1.40 leftward displacement of the dose-response curve constructed for apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 0.40 (+/- 0.05) to 0.29 (+/- 0.03). 4. Dihydroergotoxine (10.0 mg/kg) was unable to change haloperidol-induced catalepsy. 5. Results were discussed in the light of a possible interference of central noradrenergic systems with the expression of dopaminergic behaviors.
Flório
J C
JC
Applied Pharmacology and Toxicology Laboratory School of Veterinary Medicine, University of São Paulo, Brazil.
Palermo-Neto
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D002395:Catecholamines / Q000378:metabolism; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D002395:Catecholamines; D004088:Dihydroergotoxine; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine