Brugia pahangi adults implanted into mice: a possible screen for filaricidal activity.
Brugia pahangi adults grown in the peritoneal cavities of jirds (Meriones unguiculatus) were implanted into the peritoneal cavities of six inbred mouse strains to investigate this system as a screen for detecting filaricidal activity. The mice were given 15 adult B. pahangi and autopsied 35 days later. The recoveries of adult worms were 25%, 35%, 49%, 33%, 26% and 27% of the number implanted respectively for the MF1, TO, NIH, CBA, BALB/c and C3H/HE strains. There was great variation in the number of worms recovered from each strain of mouse. It is concluded that the variation in recoveries was so high that this system is not useful in detecting low level filaricidal activity.
Denham
D A
DA
London School of Hygiene and Tropical Medicine, England.
Midwinter
I T
IT
Shipley
M J
MJ
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002009:Brugia / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005260:Female; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides / Q000494:pharmacology* / Q000627:therapeutic use; D005849:Gerbillinae; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000469:parasitology*; D010529:Peritoneal Cavity / Q000469:parasitology
D000871:Anthelmintics; D005369:Filaricides