title: Rapid eradication of trichomonads by single-dosed nimorazole.
abstract: Previous in vitro studies demonstrated the rapidity of trichomonacidal action of nimorazole (Naxogin 500) which was twice that of metronidazole and many times that of tinidazole. Since rapid eradication of parasites can lead to a significant decrease in transmission rate, and hence, a lower prevalence of this sexually transmitted disease, a pilot study was designed to investigate the in vivo speed of action of nimorazole. Twenty females with positive wet smears for trichomonas vaginalis were treated with a single 2 gram-dose of nimorazole orally. Without any antiseptics, specimens of vaginal discharge were collected at 0 hour (before treatment), 3, 24 and 72 hours for parasite count and culture. After a single treatment with 2 g of nimorazole the cure rate was 65 per cent at 3 hours and 100 per cent at all points thereafter. The result of this pilot study supports previous in vitro findings that nimorazole rapidly eradicates vaginal parasites.
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Bhiraleus
authors.forename: A
authors.initials: A
authors.lastname: Roongpisuthipong
authors.forename: C
authors.initials: C
authors.lastname: Bhadrakom
authors.forename: P
authors.initials: P
authors.lastname: Patanaparnich
authors.forename: D
authors.initials: D
authors.lastname: Nacapunchai
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D008875:Middle Aged; D009554:Nimorazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D010270:Parasite Egg Count; D010865:Pilot Projects; D012749:Sexually Transmitted Diseases / Q000188:drug therapy / Q000469:parasitology; D014247:Trichomonas Vaginitis / Q000188:drug therapy* / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D009593:Nitroimidazoles; D009554:Nimorazole