title: Trauma-induced increase of extracellular ascorbate in rat cerebral cortex.
abstract: Extracellular (EC) ascorbate concentrations were measured in microdialysates from the cerebral cortex in rats subjected to cortical compression-contusion trauma. The trauma induced a transient, dramatic increase in EC ascorbate compared to the basal level before the insult and compared to control animals. The data support the presence of a releasable intracellular pool of ascorbate in the neocortex. The possibility that ascorbate may influence traumatic brain damage by its proposed neuromodulatory property and/or by its ability to induce lipid peroxidation is considered.
authors.affiliation: Department of Neurosurgery, University Hospital, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Hillered
authors.forename: P
authors.initials: P
authors.lastname: Nilsson
authors.forename: U
authors.initials: U
authors.lastname: Ungerstedt
authors.forename: U
authors.initials: U
authors.lastname: Pontén
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001205:Ascorbic Acid