Synthesis and activity of a novel, irreversible inhibitor of cathepsin B.
Cullen
B M
BM
Department of Biochemistry, Queen's University of Belfast, Northern Ireland.
McGinty
A
A
Walker
B
B
Nelson
J
J
Halliday
I
I
Bailie
J R
JR
Kay
G
G
D000818:Animals; D001665:Binding Sites; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002401:Cathepsin B / Q000037:antagonists & inhibitors*; D002417:Cattle; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D003978:Diazomethane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques
D015853:Cysteine Proteinase Inhibitors; C024918:benzyloxycarbonylphenylalanylalanine diazomethyl ketone; C064862:biotin-phenylalanyl-alanine diazomethyl ketone; D003978:Diazomethane; D001710:Biotin; D002401:Cathepsin B