title: Comparative studies on the effect of vitamin A, B1 and B6 deficiency on oxalate metabolism in male rats.
abstract: The study was conducted to investigate the effect of vitamin A, B1 and B6 deficiency on oxalate metabolism in rats. A significant hyperoxaluria was the common observation in all the three vitamin deficiencies (vitamin B6 greater than vitamin A greater than vitamin B1). The activities of hepatic glycolate oxidase and glycolate dehydrogenase were markedly enhanced in vitamin-A- and vitamin-B6-deficient rats. However, lactate dehydrogenase levels remained unaltered in these deficiencies as compared to their respective pair-fed controls. Vitamin B1 deficiency of 4 weeks' duration could augment the activity of glycolate oxidase only, with no alterations in the glycolate dehydrogenase and lactate dehydrogenase levels. Intestinal oxalate uptake studies revealed increased bio-availability of oxalate from the gut in vitamin-A- and vitamin-B6-deficient rats. Thus, the results suggest the relative contribution of both exogenous as well as endogenous oxalate in the process of calculogenesis under various nutritional stress conditions in rat.
authors.affiliation: Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: H
authors.initials: H
authors.lastname: Sidhu
authors.forename: R
authors.initials: R
authors.lastname: Narula
authors.forename: S K
authors.initials: SK
authors.lastname: Thind
authors.forename: R
authors.initials: R
authors.lastname: Nath
mesh_terms: D000818:Animals; D008297:Male; D010070:Oxalates / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000209:etiology / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*; D014804:Vitamin B Deficiency / Q000378:metabolism*
chemical_list: D010070:Oxalates