Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata.
The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily x 5 days or 17 mg/kg weekly x 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50.6% and 13.6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily x 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4.5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.
Mak
J W
JW
Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
Lam
P L
PL
Choong
M F
MF
Suresh
K
K
D000284:Administration, Oral; D000818:Animals; D002009:Brugia / Q000187:drug effects / Q000254:growth & development; D002520:Cercopithecidae; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005260:Female; D005368:Filariasis / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D008842:Microfilariae / Q000187:drug effects / Q000254:growth & development; D013498:Suramin / Q000008:administration & dosage / Q000627:therapeutic use*
D013498:Suramin; D004049:Diethylcarbamazine