[Changes in the activity of lysosomal enzymes and in the indices of cardiac contractile function in experimental diphtheria poisoning in rabbits].
Contractility of the heart ventricles and the activity of N-acetyl-beta-D-galactosaminiidase in fraction of lysosomes of this part of the heart were studied in rabbits with experimental diphtheritic intoxication. Three days after the onset of the process changes in the activity of the enzyme reached maximum and were expressed in increase of values indicating increased transfer of enzymes from the particles into the cytosol. At the same time, values which were evidence of fixation of the enzyme in the lysosomes reduced. Correlation analysis showed that intensified escape of enzymes into the cytoplasm led to weakening of heart contractile function.
Frolov
V A
VA
Shkirmante
B K
BK
Kazanskaia
T A
TA
D000818:Animals; D004165:Diphtheria / Q000201:enzymology* / Q000503:physiopathology; D004167:Diphtheria Toxin / Q000506:poisoning; D006352:Heart Ventricles / Q000201:enzymology / Q000503:physiopathology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000201:enzymology; D011817:Rabbits; D013997:Time Factors
D004167:Diphtheria Toxin
Izmenenie aktivnosti fermentov lizosom i nekotorykh pokazateleĭ sokratitel'noĭ funktsii serdtsa pri éksperimental'noĭ difteriĭnoĭ intoksikatsii u krolikov.