Effects of oxytocin and an oxytocin antagonist on testosterone secretion during the oestrous cycle of the goat (Capra hircus).
Oxytocin at a dose of 100 i.u. injected subcutaneously (s.c.) daily to goats between Days 3 and 6 of the oestrous cycle caused a significant increase in testosterone secretion compared with saline-treated animals. An oxytocin antagonist (0.2 micrograms/kg) injected intra-arterially between Days 12 and 18 of the oestrous cycle or simultaneously with oxytocin between Days 3 and 6 blocked the increased release of testosterone and occurrence of oestrus. It is suggested that oxytocin-induced oestrus may occur via testosterone secretion.
Homeida
A M
AM
Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, Sudan.
Khalafalla
A E
AE
D000818:Animals; D004971:Estrus / Q000502:physiology*; D005260:Female; D006041:Goats / Q000502:physiology*; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood / Q000378:metabolism*; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000494:pharmacology
D013739:Testosterone; D011374:Progesterone; D010121:Oxytocin; C065085:vasotocin, 1-(beta-mercapto-beta,beta-diethylpropionic acid)-(OEt-Tyr)(2)-Orn(8)-; D014668:Vasotocin