title: Delta 6 desaturase in brain and liver during development and aging.
abstract: delta 6 Desaturase was measured in the mouse brain and liver using linoleic acid as substrate. During pre- and postnatal development, delta 6 desaturase in brain decreased dramatically (12-fold) up to postnatal day 21 and remained nearly constant thereafter. In liver, the activity increased approximately 9-fold between day 3 before birth and day 7 after birth. Then it decreased slightly up to weaning and was approximately constant up to 4 mo. From then on, delta 6 desaturase decreased with age (40% between 4 and 17 mo).
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U26 Hopital Fernand Widal, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
authors.forename: M
authors.initials: M
authors.lastname: Piciotti
authors.forename: O
authors.initials: O
authors.lastname: Dumont
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005333:Fetus / Q000201:enzymology; D050602:Linoleoyl-CoA Desaturase; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D051379:Mice
chemical_list: D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase