[Dual cephalosporins--a return of fixed combinations of antibiotics?].
The author submits information on the preparation and properties of new molecules of "tailored antibiotics"--dual cephalosporins. They are formed by esterification of cephalosporins of the third generation (so far only cephotaxim) with fleroxacine or another fluoroquinolone chemotherapeutic agent. The author discusses the aptness and advantage of this new approach to the innovation of the existing spectrum of antibacterial agents.
Krcméry
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Výskumný ústav preventívneho lekárstva, Bratislava.
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004338:Drug Combinations; D016576:Fleroxacin / Q000031:analogs & derivatives*; D024841:Fluoroquinolones
D000890:Anti-Infective Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; C060441:Ro-23-9424; D002939:Ciprofloxacin; D002439:Cefotaxime; D016576:Fleroxacin
Duálne cefalosporíny--návrat fixných kombinácií antibiotík?