Pharmacokinetics of fluconazole in serum and cerebrospinal fluid in a patient with AIDS and cryptococcal meningitis.
The detailed pharmacokinetics of fluconazole in serum and cerebrospinal fluid (CSF) were studied in a patient with acquired immunodeficiency syndrome and cryptococcal meningitis, after an intravenous dose of 400 mg. Fluconazole exhibited a serum elimination half-life of 34.2 hours, distribution volume of 0.56 L/kg, and clearance of 0.19 ml/min/kg. Peak CSF concentration occurred at 4 hours after the dose. Overall penetration of fluconazole based on the ratio of areas under the curve of CSF to serum was 70%. The drug exhibited an excellent pharmacokinetic profile for treatment of central nervous system fungal infections.
Chin
T
T
Department of Pharmacy, St. Michael's Hospital, Toronto, Ontario, Canada.
Fong
I W
IW
Vandenbroucke
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications* / Q000378:metabolism; D000328:Adult; D003454:Cryptococcus; D015725:Fluconazole / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D013997:Time Factors
D015725:Fluconazole