[Thrombin-fibrinogen interaction: release of fibrinopeptides and the effects of ATP].
This study presents experimental data on the time dependence of the release of fibrinopeptides A and B following the interaction between thrombin and fibrinogen. It is found that the release of fibrinopeptide A is fast as compared to that of fibrinopeptide B. This process is modulated by ATP in a complex fashion. In fact, the release of fibrinopeptide A is first enhanced at low (less than 1 mM) ATP concentrations and then progressively inhibited at ATP concentrations greater than 1 mM. These results draw attention to a possible model for the in vivo modulation of thrombin activity by ATP.
Gurrieri
M A
MA
Semeiotica Medica, Università Cattolica Sacro Cuore.
D000255:Adenosine Triphosphate / Q000494:pharmacology* / Q000502:physiology; D005340:Fibrinogen / Q000502:physiology*; D005344:Fibrinopeptide A / Q000502:physiology; D005345:Fibrinopeptide B / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D013917:Thrombin / Q000502:physiology*; D013997:Time Factors
D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D000255:Adenosine Triphosphate; D005340:Fibrinogen; D013917:Thrombin
Interazione trombina-fibrinogeno: rilascio dei fibrinopeptidi ed effetto dell'ATP.