Is the detection of fucose cancer markers by 2D 1H NMR unequivocal?
Fucose is believed to be a marker for cancer that may be detectable by the 2D proton NMR (COSY) of human plasma. However, the COSY technique is time consuming and prone to error. These problems may be alleviated by using the SUPERCOSY pulse sequence; this technique shows that there are many other cross peaks in the region (1.3, 4.2 ppm) which are not readily distinguishable from fucose.
Phillips
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PS
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Herring
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FG
D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005643:Fucose / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D014408:Biomarkers, Tumor; D005643:Fucose