[Clinico-biological classification of systemic lupus].
Anti-nuclear and anti-cytoplasmic antibodies are found in nearly 99% of systemic lupus erythematosus (SLE) patients. Among the different antibodies described, 2 are highly specific for SLE although their frequencies differ considerably. Anti-dsDNA (anti-native DNA) antibodies are detected at some point during disease evolution in 65-95% of the patients, whereas anti-Sm antibodies occur in only 7-30% of the cases, with wide variations according to race and geographical origin. The present study attempts to correlate specific clinical manifestations as a function of certain antibodies: SLE with anti-U1 RNP, with or without anti-dsDNA; SLE with anti-histones; SLE with anti-Ro (SS-A); SLE with anti-phospholipid antibodies or anti-type 5 mitochondrial antibodies; and SLE with anti-ribosomal antibodies. The diversity of these clinical-biological subgroups tends to imply that SLE is a syndrome rather than a distinct disease state.
Meyer
O
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Clinique de Rhumatologie, Université Paris-VII, Hôpital Bichat.
D000974:Antibodies, Antinuclear / Q000502:physiology*; D001323:Autoantibodies / Q000502:physiology; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000145:classification* / Q000175:diagnosis / Q000276:immunology; D012698:Serologic Tests; D013577:Syndrome
D000974:Antibodies, Antinuclear; D001323:Autoantibodies
Classification clinico-biologique des lupus systémiques.