[Effects of heptapeptide of the tuftsin group with nootropic components of action and piracetam on formation of escape reaction in normal conditions and in conflict situation].
In this work we have compared the effect of Tuftsin Group synthetic heptapeptide (TP-1) and Piracetam on learning of avoidance response and its restoring after disturbance provoked by unexpected changes of previously established cause-effect relations in experimental environment. We have pointed out that both of the drugs improve learning but the dynamics is different, namely: Piracetam causes the greatest improvement on the 1st day, meanwhile the Heptapeptide--on the 4th day. Both of them preclude from disturbing avoidance response and this protective action of peptide is more effective.
Inozemtsev
A N
AN
Kokaeva
F F
FF
Kozlovskiĭ
I I
II
Sarychev
E I
EI
Demidov
V M
VM
Tushmalova
N A
NA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003220:Conflict, Psychological; D004924:Escape Reaction / Q000187:drug effects*; D008297:Male; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014405:Tuftsin / Q000008:administration & dosage / Q000494:pharmacology*
D011760:Pyrrolidinones; D014405:Tuftsin; D010889:Piracetam
Vliianie geptapeptida gruppy taftsina s nootropnym komponentom deĭstviia i piratsetama na formirovanie reaktsii izbeganiia v norme i pri ee narushenii v usloviiakh konfliktnoĭ situatsii.