[Experimental bases of directed transport of antibiotics in suppurative-inflammatory diseases of the liver and biliary tract].
The possibility of use and effectiveness of directed transport of antibiotics in erythrocyte carriers in the treatment of suppurative-inflammatory diseases of biliary ducts has been studied on dogs. It has been found that erythrocyte carriers were resistant to desorption of antibiotics in the blood circulation. Pharmacokinetic investigation has shown the more prolonged collection of antibiotics in hepatic tissue in comparison with traditional intravenous route. The results of clinical, pharmacokinetic and morphological investigation have shown more effectiveness of directed transport of antibiotics to the liver in autologous erythrocyte carriers in treatment of suppurative diseases of biliary ducts in comparison with traditional methods of infusion of antibiotics. For reasons given it is recommended to use this method in clinical practice.
Zhumadilov
Zh Sh
ZhSh
Skuba
N D
ND
Makarenkova
R V
RV
D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D002764:Cholecystitis / Q000188:drug therapy*; D004285:Dogs; D004337:Drug Carriers; D004912:Erythrocytes; D007612:Kanamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy*; D013492:Suppuration
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D007612:Kanamycin
Eksperimental'noe obosnovanie napravlennogo transporta antibiotikov pri gnoĭno-vospalitel'nykh zabolevaniiakh pecheni i zhelchnykh puteĭ.