title: [Use of urokinase in the occlusion of the vascular access routes in chronic hemodialysis. 7 years' experience].
abstract: Pharmacological treatment with urokinase in obstructions of vascular accesses due to chronic dialysis is a tried and tested technique. Retrospective investigation of a group of 111 cases treated with urokinase makes it possible to calculate the actuarial survival curve of vascular access in the period subsequent to fibrinolytic treatment. Mathematical analysis provides a precise indication to the use of the drug in thromboses of a-v fistulas and anatomically unimpaired vascular prothesies. In the presence of stenosis of a-v anastomosis, pharmacological thrombolysis permits restoration of a blood flow suitable to the conduction of haemodialytic treatment for a period useful to surgical correction. Infusion of urokinase is useless in cases of vascular prosthesis thrombosis complicated by the presence of stenosis of the lumen.
authors.affiliation: U.S.S.L. n. 70, Ospedale Civile, Alessandria, Divisione di Nefrologia e Dialisi.
authors.forename: A
authors.initials: A
authors.lastname: Ortensia
authors.forename: M
authors.initials: M
authors.lastname: Delle Volpe
authors.forename: M
authors.initials: M
authors.lastname: Iberti
authors.forename: G V
authors.initials: GV
authors.lastname: Veronesi
authors.forename: G
authors.initials: G
authors.lastname: De Micheli
mesh_terms: D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D004341:Drug Evaluation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D015993:Life Tables; D006435:Renal Dialysis; D012189:Retrospective Studies; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Uso dell'urochinasi nell'occlusione di accessi vascolari per emodialisi cronica. Sette anni di esperienza.