[Pharmacological study on Agkistrodon blomhoffii blomhoffii Boie. II. Effect of 50% ethanolic extract on phagocytic activity of mouse reticuloendothelial system].
Effect of a 50% ethanolic extract ([M]) from dried whole body of Agkistrodon blomhoffii blomhoffii Boie on a phagocytic activity of reticuloendothelial system was studied by the carbon clearance method in mice. The clearance-rate of carbon was significantly shortened 1 h after the oral administration of [M] (250 or 500 mg/kg, one time/d for 3d). [M] activated the phagocytosis of carbon by macrophage (M phi) in the spleen and the phagocytosis of latex by peritoneal M phi. These results suggested that [M] may promote the phagocytic activity on the reticuloendothelial system in mice and has a stimulatory effect on M phi.
Moriura
T
T
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Matsuda
H
H
Kubo
M
M
D000818:Animals; D008264:Macrophages / Q000276:immunology; D008297:Male; D008419:Materia Medica; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D012911:Snakes; D014020:Tissue Extracts / Q000494:pharmacology*
D008419:Materia Medica; D014020:Tissue Extracts