Synthesis and pharmacological activity of 6H-thiazolo [3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives, a new heterocyclic ring system.
In the outline of the investigations concerning the analgesic and antiinflammatory activity of new fused heterocyclic compounds containing the pyrimidine ring, a series of 6H-thiazolo[3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives was synthesized. Pharmacological results are reported and discussed.
Russo
F
F
Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Catania, Italy.
Romeo
G
G
Guccione
S
S
Bousquet
E
E
Caruso
A
A
Leone
M G
MG
Attaguile
G
G
Roxas
M A
MA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005122:Exudates and Transudates / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D011743:Pyrimidines; D013844:Thiazoles; D002351:Carrageenan