Recent advances in the management of lung and breast cancer. Future directions.
Since mortality from breast cancer remains unacceptably high, hopes for future treatment depend, in large part, on the development of pharmacologic interventions based on an increased understanding of the biology of cancer. A fruitful area of exploration may be that of antisense RNAs which may inhibit the expression of a given growth factor or a given cellular product. It is also possible that an antisense RNA can be developed that will inhibit the production of proteins responsible for drug resistance. Another potential approach is the use of the Her-2-Neu oncogene cell membrane protein target for monoclonal antibody radioimmunoconjugates for therapy. Finally, since low-fat, reduced-calorie diets are considered an important part of preventive programs, the use of artificial fats may also make a significant difference in changing life-style habits.
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Arizona Cancer Center, University of Arizona College of Medicine, Tucson 85724.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D004351:Drug Resistance; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D005544:Forecasting; D006801:Humans; D008207:Lymphatic Metastasis
D000970:Antineoplastic Agents; D004965:Estrogen Antagonists