title: [A case of double primary malignancy of intracranial germinoma and thymoma controlled by radiotherapy].
abstract: We report a case of double primary malignancy, in which intracranial germinoma and thymoma occurred successively and independently. As curative therapies, the former lesion was treated by definitive irradiation and the latter by postoperative irradiation. Excellent local control has been maintained for 79 and 49 months, respectively, since the beginning of the radiotherapy. The accumulated dose to the thoracic spinal cord was 63.5 Gy. No symptoms suggesting the onset of radiation myelopathy, the most critical late radiation injury, have been observed up to now. We also investigated radiobiological effect to the spinal cord assessed by the formulae of CRE and TDF.
authors.affiliation: Department of Radiology, University of Tsukuba School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Okumura
authors.forename: K
authors.initials: K
authors.lastname: Ohara
authors.forename: S
authors.initials: S
authors.lastname: Sugawara
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Akisada
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004407:Dysgerminoma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D011879:Radiotherapy Dosage; D013945:Thymoma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed