title: A comparison of micronucleus induction in 3 mouse strains with representative clastogens.
abstract: The frequency of micronucleated polychromatic erythrocytes (MNPCEs) was compared in BALB/c, C57BL/6 and DBA/2 mice after the intraperitoneal injection (i.p.) of methyl methanesulfonate (MMS), potassium chromate (K2CrO4), colchicine (COL), cycloheximide (CYH), 4-nitroquinoline-1-oxide (4-NQO) and 5-fluorouracil (5-FU). In BALB/c mice, the frequency of MNPCEs was significantly increased by all the chemicals tested, as compared to the vehicle control. In both C57BL/6 and DBA/2 mice, MMS, K2CrO4, COL and 4-NQO significantly increased MNPCEs, but CYH and 5-FU only slightly increased the MNPCEs in C57BL/6 and had no effect on DBA/2 mice. These results suggest that BALB/c mice are more sensitive to the induction of MNPCEs with a wider spectrum of chemicals than C57BL/6 or DBA/2 mice.
authors.affiliation: Toxicology Research Laboratories, Japan Tobacco Inc., Kanagawa.
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Takizawa
authors.forename: N
authors.initials: N
authors.lastname: Inui
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D009153:Mutagens