Simultaneous determination of quinidine and butyrophenones in human plasma by GC-MS.
This report describes a sensitive GC and HRGC-MS procedure for the simultaneous determination of Quinidine and some bytyrophenone drugs in human plasma. The quantitative response is linear from 50-250 ng/ml using Pipamperone as international standard. It is suitable for clinical analysis at therapeutic levels.
Quaglio
M P
MP
Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.
Bellini
A M
AM
Minozzi
L
L
Frisina
G
G
Testoni
F
F
D002090:Butyrophenones / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D011802:Quinidine / Q000097:blood*; D012015:Reference Standards; D012996:Solutions
D002090:Butyrophenones; D007202:Indicators and Reagents; D012996:Solutions; D011802:Quinidine