[Effect of Chinese green tea extracts on the human gastric carcinoma cell in vitro].
We have studied and found antitumor effects in Chinese green tea extracts (T-8750). By pharmacologic test, it showed anticancer actions against several kinds of tumors in NIH mice evidently. Clinical trials on the therapeutics effects against early stomach cancer showed very effective. In order to prove it's function to prevent cancer. The research results as follows: (1) In vitro, T-8750 (0.5-1 mg/ml) could inhibit the cell growth of SGC (stomach gastric cancer) significantly. The inhibition action are obviously within 12-24 hr. (2) T-8750 traversed the migration of cell line L1210 from G1 phase to S phase, the rate were (63%). (3) In vitro, the blocking effect of T-8750 on the nitrosation of morpholine-nitrite was (92.4%). (4) the effect of T-8750 scavenger harmful free radicals was (63%).
Yan
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Chinese Cancer Research Foundation Association, Nanjing Zhong Shan Institute.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000970:Antineoplastic Agents; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology*; D013662:Tea / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010936:Plant Extracts; D013662:Tea