title: Cardiac and skeletal muscle adaptations to training in systemic hypertension and effect of beta blockade (metoprolol or propranolol).
abstract: Cardiovascular and peripheral adaptations to an aerobic conditioning program were studied in 30 hypertensive adults taking either placebo, beta 1-selective beta-adrenergic blocker (metoprolol) or beta 1-nonselective beta-adrenergic blocker (propranolol). The placebo group increased aerobic capacity (VO2max) 24% (p less than 0.002), largely explained by an increased peripheral arteriovenous (AV) oxygen difference with minimal changes in cardiac size and function. Resting blood pressure and total systemic resistance also decreased. The group taking a beta 1-selective beta blocker increased VO2max 8% (p less than 0.05), reduced resting blood pressure but had no significant change of AV oxygen difference or cardiac size or function. The group taking the beta 1-nonselective beta blocker propranolol had no increase in VO2max, no decrease in resting blood pressure and no cardiovascular or peripheral adaptations to the exercise program. Thus, beta 1-selective and beta 1-nonselective beta blockers attenuate conditioning in hypertensive patients to differing degrees, in each case by blocking peripheral mechanisms of conditioning.
authors.affiliation: Division of Cardiology, University of Vermont College of Medicine, Burlington.
authors.forename: P A
authors.initials: PA
authors.lastname: Ades
authors.forename: P G
authors.initials: PG
authors.lastname: Gunther
authors.forename: W L
authors.initials: WL
authors.lastname: Meyer
authors.forename: T C
authors.initials: TC
authors.lastname: Gibson
authors.forename: J
authors.initials: J
authors.lastname: Maddalena
authors.forename: T
authors.initials: T
authors.lastname: Orfeo
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D005081:Exercise Therapy; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects* / Q000503:physiopathology; D010101:Oxygen Consumption / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D011433:Propranolol; D008790:Metoprolol