title: [The effect of L-carnitine on the energy metabolism of isolated rat heart perfused by Langendorff's method using 31P-NMR spectroscopy].
abstract: 31P-NMR spectroscopy is a method for continuous, noninvasive determination of high-energy phosphates in the intact organ. On the isolated Langendorff perfused rat heart the effect of L-carnitine on concentration of cytosolic ATP and phosphocreatine was studied under influence of a single or repeated periods of 20 min ischemia. On reperfusion the carnitine-treated hearts showed higher CP/Pi values and an increase of the energy index (CP + ATP)/(C) + ATP + Pi) then did control hearts. An improved ischemia tolerance was demonstrated.
authors.affiliation: Institut für Pathologische Biochemie, Bereichs Medizin, Karl-Marx-Universität Leipzig.
authors.forename: H
authors.initials: H
authors.lastname: Löster
authors.forename: W
authors.initials: W
authors.lastname: Gründer
authors.forename: T
authors.initials: T
authors.lastname: Keller
authors.forename: H
authors.initials: H
authors.lastname: Seim
authors.forename: J
authors.initials: J
authors.lastname: Grommisch
authors.forename: F
authors.initials: F
authors.lastname: Müller
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015425:Myocardial Reperfusion; D010725:Phosphocreatine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D002331:Carnitine
vernacular_title: Untersuchungen zum Einfluss von L-Carnitin auf den Energiestoffwechsel des isolierten, nach Langendorff perfundierten Rattenherzens mittels 31P-NMR-Spektroskopie.