Arginine residues are involved in the transport function of bilitranslocase.
Specific guanido group reagents inhibit bilitranslocase transport activity in rat liver plasma membrane vesicles. Their reaction is shown to be affected by sulfobromophthalein, Thymol blue and bilirubin, which are translocated by bilitranslocase across the plasma membrane. It is concluded that the transport function of bilitranslocase depends on arginine residues, which are involved in the interaction with the molecules to be translocated.
Passamonti
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S
Dipartimento di Biochimica Biofisica e, Chimica delle Macromolecole, Università degli Studi di Trieste, Italy.
Battiston
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L
Sottocasa
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GL
D000838:Anions; D001120:Arginine; D001663:Bilirubin / Q000378:metabolism*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002570:Ceruloplasmin; D008099:Liver / Q000378:metabolism*; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000378:metabolism*; D010658:Phenylglyoxal / Q000494:pharmacology; D011765:Pyruvaldehyde / Q000494:pharmacology; D013448:Sulfobromophthalein / Q000378:metabolism
D000838:Anions; D008565:Membrane Proteins; D013448:Sulfobromophthalein; D011765:Pyruvaldehyde; D001120:Arginine; D002570:Ceruloplasmin; C033838:bilitranslocase; D010658:Phenylglyoxal; D001663:Bilirubin