Novel structural concepts in elucidating the potential genotoxicity and carcinogenicity of tetrandrine, a traditional herbal drug.
Tetrandrine, a widely used remedy, is predicted to be a 'genotoxic' carcinogen. This finding suggests that the usage of this substance in non-life-threatening situations should be evaluated.
Rosenkranz
H S
HS
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Klopman
G
G
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D044182:Benzylisoquinolines; D002273:Carcinogens; D005103:Expert Systems; D007256:Information Systems; D051379:Mice; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats
D000470:Alkaloids; D044182:Benzylisoquinolines; D002273:Carcinogens; D009153:Mutagens; C009438:tetrandrine