title: Pulsed dye laser treatment of telangiectases with and without subtherapeutic sclerotherapy. Clinical and histologic examination in the rabbit ear vein model.
abstract: The treatment of leg telangiectases with the carbon dioxide or argon laser results in a low success rate and an unacceptable risk of scarring. Sclerotherapy is effective; however, pigmentation and telangiectatic matting induced by extravasation of RBCs and excessive posttreatment inflammation are common. We conducted a clinical and histologic study of therapy with the 585 nm pulsed dye laser alone and in combination with subtherapeutic sclerotherapy in the rabbit ear vein model. The pulsed dye laser alone was effective when 10 joule/cm2 was used. In combination with immediate injection of the sclerosant, effective endosclerosis occurred with all tested laser energies (8 to 10 joule/cm2).
authors.affiliation: Department of Medicine, University of California School of Medicine.
authors.forename: M P
authors.initials: MP
authors.lastname: Goldman
authors.forename: D E
authors.initials: DE
authors.lastname: Martin
authors.forename: R E
authors.initials: RE
authors.lastname: Fitzpatrick
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Esparza
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D004423:Ear / Q000098:blood supply; D004730:Endothelium, Vascular / Q000473:pathology; D004912:Erythrocytes / Q000473:pathology; D053685:Laser Therapy; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011817:Rabbits; D011897:Random Allocation; D012597:Sclerosing Solutions / Q000627:therapeutic use; D015911:Sclerotherapy; D013684:Telangiectasis / Q000473:pathology / Q000532:radiotherapy* / Q000628:therapy; D013924:Thrombophlebitis / Q000473:pathology; D014680:Veins
chemical_list: D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols