title: Bovine citrullinaemia: a clinical, pathological, biochemical and genetic study.
abstract: Calves affected with citrullinaemia are clinically normal immediately after birth. In the majority of calves the clinical course of the disease was similar. Within 24 hours of birth they become depressed; then within 3 to 4 days were observed to wander aimlessly or stand with their head pressed against a wall or fence. By day 4 to 5 they become recumbent, developed convulsions, followed by collapse and death. Oedema of the cerebral cortex is a consistent histological lesion. Citrulline concentration in blood, cerebrospinal fluid, eye fluid and cerebral tissue is greatly elevated. Information gathered from pedigrees of affected calves indicate that the defect is widely disseminated throughout the Australian Friesian population.
authors.affiliation: Elizabeth Macarthur Agricultural Institute, Menangle, New South Wales.
authors.forename: P J
authors.initials: PJ
authors.lastname: Healy
authors.forename: P A
authors.initials: PA
authors.lastname: Harper
authors.forename: J A
authors.initials: JA
authors.lastname: Dennis
mesh_terms: D000818:Animals; D001124:Argininosuccinate Synthase / Q000172:deficiency*; D001929:Brain Edema / Q000473:pathology / Q000662:veterinary; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002956:Citrulline / Q000032:analysis / Q000097:blood* / Q000134:cerebrospinal fluid; D005260:Female; D008025:Ligases / Q000172:deficiency*; D008099:Liver / Q000473:pathology; D008297:Male
chemical_list: D002956:Citrulline; D008025:Ligases; D001124:Argininosuccinate Synthase