title: Hereditary cerebellar degeneration with downbeat nystagmus. A case and it's treatment.
abstract: We present a female patient of 48 years with downbeat nystagmus (DBN), moderate impairment of coordination testing and a family history of cerebellar ataxia. We report that a single 2 mg dose of clonazepam (following Currie & Matsuo) resulted in a virtual disappearance of nystagmus and of the patient's symptom of oscillopsia. This result is interpreted in terms of current models of DBN.
authors.affiliation: Department of Physiology, University of Otago, Dunedin, New Zealand.
authors.forename: H W
authors.initials: HW
authors.lastname: McConnell
authors.forename: C L
authors.initials: CL
authors.lastname: Darlington
authors.forename: P F
authors.initials: PF
authors.lastname: Smith
authors.forename: D L
authors.initials: DL
authors.lastname: Sturge
authors.forename: S D
authors.initials: SD
authors.lastname: Thomson
authors.forename: H
authors.initials: H
authors.lastname: Nukada
authors.forename: M W
authors.initials: MW
authors.lastname: Mair
mesh_terms: D002524:Cerebellar Ataxia / Q000150:complications / Q000235:genetics*; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000188:drug therapy / Q000209:etiology*
chemical_list: D002998:Clonazepam