The first organoantimony(III) compounds possessing antitumor properties: diphenylantimony(III) derivatives of dithiophosphorus ligands.
Two organoantimony (III) derivatives, i.e., diphenylantimony diphenyl-dithiophosphinate, Ph2SbS2PPh2, and diphenylantimony diizopropyldithiophosphate, Ph2SbS2P(OPri)2, were shown to exhibit antitumor properties. Both compounds produced strong tumor inhibition effects in mice bearing Ehrlich ascites tumor. Moreover, the dithiophosphate (15 mg/kg, i.p., in days 1, 3 and 5) produced a cure rate of 30%.
Silvestru
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C
Chemistry Department, University of Cluj-Napoca, Romania.
Socaciu
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C
Bara
A
A
Haiduc
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I
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009946:Organothiophosphorus Compounds; C064871:diphenylantimony diphenyldithiophosphinate; C064870:diphenylantimony diisopropyldithiophosphate