title: Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia.
abstract: The effect of direct current stimulation on bone formation during limb lengthening was tested in a lower leg lengthening model in the rabbit. Limb lengthening was performed by distraction epiphysiolysis. A specially designed external distraction device was placed at the tibia. The distractor allowed 10 mm of lengthening in 4 weeks. Two weeks after starting the distraction, a platinum electrode was passed through the anterior cortex below the tibial tuberosity and advanced via the medullary cavity so that the tip rested in the elongated zone. Stimulation started at the time of placement of the electrodes and was continued for 3 weeks. The electrode in the elongated zone served as the cathode; the anode was placed subcutaneously. A 20 microA stimulus was selected. A control group received the same treatment without stimulation. Bone formation in the elongated zone was evaluated by histology and scintigraphy. The data from this experiment show that direct current stimulation in the early phase of a limb lengthening procedure had no effect on the extent of bone formation in the elongated zone.
authors.affiliation: Department of Orthopaedic Surgery, State University of Utrecht, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: van Roermund
authors.forename: A
authors.initials: A
authors.lastname: Hoekstra
authors.forename: W J
authors.initials: WJ
authors.lastname: Visser
authors.forename: W
authors.initials: W
authors.lastname: Renooij
mesh_terms: D000818:Animals; D001852:Bone Lengthening / Q000379:methods*; D004558:Electric Stimulation; D005260:Female; D010012:Osteogenesis; D011817:Rabbits; D011859:Radiography; D011877:Radionuclide Imaging; D013977:Tibia / Q000000981:diagnostic imaging / Q000254:growth & development*