title: [The dynamics of antibody formation to a vaccinal strain of Francisella tularensis in different immunization regimens].
abstract: The use of different schemes of albino mice immunization either by living or by killed preparations of the vaccine strain of Francisella tularensis when obtaining monoclonal antibodies to the tularemia microbe made it possible to reveal definite regularities in the dynamics of antibody formation. The highest titres of antibodies in sera of animals-donors of splenocytes were obtained during the daily (for 3 days) intraperitoneal immunization of mice with living vaccine or with its thrice administration to the spleen thrice with the interval of 10 days. Revaccination against a background of high titres of antibodies decreased their quantity in blood serum of mice, while that against a background of low titres increased them.
authors.forename: I Ia
authors.initials: IIa
authors.lastname: Cherepakhina
authors.forename: V N
authors.initials: VN
authors.lastname: Kozlovskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Efanova
authors.forename: A S
authors.initials: AS
authors.lastname: Novokhatskiĭ
authors.forename: L P
authors.initials: LP
authors.lastname: Alekseeva
authors.forename: V V
authors.initials: VV
authors.lastname: Sukhar'
authors.forename: L A
authors.initials: LA
authors.lastname: Prozorova
authors.forename: L V
authors.initials: LV
authors.lastname: Larionova
authors.forename: V M
authors.initials: VM
authors.lastname: Sorokin
authors.forename: L K
authors.initials: LK
authors.lastname: Lysova
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis*; D000918:Antibody Specificity / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated
vernacular_title: Dinamika obrazovaniia antitel k vaktsinnomu shtammu Francisella tularensis pri razlichnykh skhemakh immunizatsii.