[The effect of the acute and chronic administration of melatonin on the relearning of rats in a Y maze and their sensitivity to haloperidol].
After acute (10 mg/kg) and chronic (1 mg/kg, 10 days) administration melatonin facilitated parameters of rats relearning in the Y-maze. A simultaneous shortening of latency avoidance reaction was observed. Haloperidol (0.1 mg/kg) against the background of chronic melatonin administration more strongly optimized the animals' relearning. The hormonal action is supposed to depend on its sedative properties.
Ovanesov
K B
KB
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006220:Haloperidol / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D006220:Haloperidol; D008550:Melatonin
Vliianie ostrogo i khronicheskogo vvedeniia melatonina na pereobuchenie krys v U-obraznom labirinte i ikh chuvstvitel'nost' k galoperidolu.