Effects of lithium and rubidium on immune responses of rats.
Rats were treated with LiCl or RbCl in drinking water for 65 days. Spleen cells from both treated groups exhibited significantly greater proliferative responses to lipopolysaccharide (LPS) than those from untreated controls. Responses to concanavalin A (Con A) were not affected. Cytotoxic activities of natural killer (NK) cells from both treated groups were significantly less than those from untreated controls. In vitro, Li augmented responses of spleen cells to LPS, but the same doses of Rb suppressed the responses. Effects on responses to Con A were variable. Both Li and Rb alone had a small mitogenic effect on spleen cells.
Jones
J M
JM
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Yeralan
O
O
Hines
G
G
Maher
M
M
Roberts
D W
DW
Benson
R W
RW
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012413:Rubidium / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D013936:Thymidine / Q000378:metabolism
D008070:Lipopolysaccharides; D003208:Concanavalin A; D008094:Lithium; D012413:Rubidium; D013936:Thymidine