title: The development of a sedation model in dogs.
abstract: The effect of various sedatives (ketamine, valium, acetylpromazine) on the saliva flow rate, swallowing capacity, muscle rigidity and ability to immobilize in an upright position was investigated in dogs. Ten healthy beagle dogs (3, six months old, 3, six years old, and 4 fourteen years old) were used for this study. A combination of ketamine (5 mg/kg) and acetylpromazine (0.175 mg/kg) produced the desired effect of normal saliva flow rate, swallowing capacity and muscle rigidity; immobilization in an upright position was attained. The saliva flow rate (unsedated) was found to decrease with increasing age of the dogs. The time to recovery from the ketamine/acetylpromazine sedation increased with increasing age of the dogs.
authors.affiliation: Division of Pharmaceutics, University of Cincinnati Medical Center, OH.
authors.forename: M L
authors.initials: ML
authors.lastname: Wilson
authors.forename: W A
authors.initials: WA
authors.lastname: Ritschel
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003679:Deglutition / Q000187:drug effects; D004285:Dogs; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008960:Models, Psychological; D009127:Muscle Rigidity / Q000139:chemically induced / Q000503:physiopathology; D012472:Salivation / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives