title: [Clinical study on the use of retrograde cardioplegia with St. Thomas' Hospital solution].
abstract: One hundred and three consecutive patients with aortic valve disease and twenty seven patients with ischemic heart disease of severe critical coronary stenosis or left main trunk stenosis underwent open heart operations with the use of retrograde cardioplegic technique for myocardial protection. Under complete cardiopulmonary bypass, a balloon catheter was inserted into the coronary sinus through small right atriotomy and secured in place. Retrograde cardioplegia was accomplished using cold St. Thomas' Hospital solution by drip method at height of 60 to 80 cm with topical saline slush. Cardiac resuscitation was very easy and acceptable hemodynamics were obtained in all patients. Even in 8 patients in which aortic crossclamping time was above 180 minutes cardiac recovery was excellent except one who needed IABP support. Eight patients in aortotomy group were died postoperatively from the reasons unrelated to myocardial protection. Postoperative hemodynamic data and enzymatic analyses of CK-MB revealed good myocardial protective effects. Retrograde cardioplegia with the use of cold St. Thomas' Hospital solution is thus an effective alternative of myocardial protection in aortic valve surgery or aortotomy surgery and in coronary revascularization for multiple coronary stenoses or left main trunk lesions.
authors.affiliation: Department of Cardiovascular Surgery, Akita University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Sakurada
authors.forename: R
authors.initials: R
authors.lastname: Kuribayashi
authors.forename: S
authors.initials: S
authors.lastname: Sekine
authors.forename: H
authors.initials: H
authors.lastname: Aida
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Meguro
authors.forename: R
authors.initials: R
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D001011:Aorta / Q000601:surgery; D001021:Aortic Valve / Q000601:surgery; D001639:Bicarbonates / Q000627:therapeutic use; D002122:Calcium Chloride / Q000627:therapeutic use; D002314:Cardioplegic Solutions; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods; D006349:Heart Valve Diseases / Q000601:surgery; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011189:Potassium Chloride / Q000627:therapeutic use; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D001639:Bicarbonates; D002314:Cardioplegic Solutions; C041711:St. Thomas' Hospital cardioplegic solution; D012965:Sodium Chloride; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride