Preparation and biokinetic evaluation of various halogenated iminodiacetic acid-type compounds labeled with technetium-99m for hepatobiliary scintigraphy in the baboon (Papio ursinus) model.
In an evaluation of various 99mTc-labeled halogenated (F, Cl, Br, I) iminodiacetic acid (IDA) derivatives for hepatobiliary scintigraphy, it was found that, in the baboon model, none of these compounds performed as well as did disida. F-IDA was least effective, with the lowest biliary excretion and highest renal participation, but multihalogen substitution as in penta-F-IDA increased the biliary specificity and reduced urinary excretion to the extent that penta-F-IDA scored second to disida and even above I-IDA, with its high molecular weight. Surprising also was the relatively good performance of Cl-IDA compared to Br-IDA and I-IDA.
Dormehl
I C
IC
Institute for Life Sciences, University of Pretoria, South Africa.
Grobbelaar
C
C
van Wyk
A
A
Jacobs
L
L
Maree
M
M
Oliver
D
D
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D006219:Halogens; D007098:Imino Acids / Q000138:chemical synthesis*; D008099:Liver / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010215:Papio; D011877:Radionuclide Imaging; D013667:Technetium; D019785:Technetium Tc 99m Disofenin; D014018:Tissue Distribution
D006219:Halogens; D007098:Imino Acids; D015609:Organotechnetium Compounds; D013667:Technetium; D019785:Technetium Tc 99m Disofenin; C008109:iminodiacetic acid