The antioxidative properties of carnosine and other drugs.
The antioxidative effect of various drugs on lipid peroxidation in rat serum in the presence of FeSO4 was studied. The concentration of TBA-active products decreased in the presence of carnosine and anticataract drugs (Japanese Catalin, Chinese Baineiting and Finnish Catachrom-OFTAN). Vita-iodurol (France) and Quinax (USA) were completely inert. One of feasible mechanisms underlying certain pathologies (cataract, rheumatism, etc.) is the damage of biomembranes by active oxygen species. The potent antioxidative activity of carnosine reflects the high therapeutic value of this compound.
Chasovnikova
L V
LV
Institute of Physico-Chemical Medicine, Moscow, USSR.
Formazyuk
V E
VE
Sergienko
V I
VI
Boldyrev
A A
AA
Severin
S E
SE
D000166:Acridines / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology*; D002386:Cataract / Q000188:drug therapy; D004151:Dipeptides / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D010078:Oxazines / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D013858:Thiobarbiturates / Q000494:pharmacology; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000166:Acridines; D004151:Dipeptides; D005296:Ferrous Compounds; D010078:Oxazines; D013858:Thiobarbiturates; C027197:phacolysin; D014810:Vitamin E; C004580:pirenoxine; C020748:ferrous sulfate; D002336:Carnosine; D024502:alpha-Tocopherol; D024505:Tocopherols; D001241:Aspirin