title: Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation.
abstract: Polymethoxylated flavones and C-glycosyl derivatives isolated from medicinal plants besides other flavonoid compounds were studied for their influence on lipid peroxidation induced by FeSO4+ cysteine in rat liver microsomes. A number of hydroxyflavones (e.g. luteolin); C-glycosyl-flavones (e.g. orientin); methoxyflavones (e.g. gardenin D) and flavonols (e.g. datiscetin), as well as the flavanol leucocyanidol and the biflavone amentoflavone behaved as inhibitors of non-enzymic lipid peroxidation. Structure-activity relationships were established and it was observed that the structural features for active polyhydroxylated compounds were different from those of polymethoxylated flavones, antiperoxidative flavonoids possessing a high lipophilicity.
authors.affiliation: Departamento de Farmacología y Farmacotecnia, Facultad de Farmacía, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Mora
authors.forename: M
authors.initials: M
authors.lastname: Payá
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
authors.forename: M J
authors.initials: MJ
authors.lastname: Alcaraz
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids