Non-mutagenic carcinogens are primarily hydrophobic.
There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients than mutagenic ones. This property of non-mutagenic carcinogens may suggest that their ability to induce tumors is associated with membraneous receptor sites and/or a longer residence time in the animal.
McCoy
G D
GD
Department of Environmental Health Sciences, Case Western Reserve University, Cleveland, OH 44106.
Rosenkranz
H S
HS
Klopman
G
G
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000145:classification / Q000378:metabolism* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation; D051381:Rats
D002273:Carcinogens; D004247:DNA