[Changes in the invasive process and the immune response of the host during the mebendazole and voltaren treatment of experimental trichinelliasis in guinea pigs].
Guinea pigs infested with Trichinella (5-10 larvae per 1 g body weight) at the intestinal (at days 2-4 of infection), migration al (at days 6-11), and muscular (at days 22-27) stages of invasion, were given voltaren, 2.14 mg/kg daily, and mebendazole, 75 mg/kg daily. The amount of adult Trichinella in small intestine and larvae in the diaphragm, T- and B-lymphocyte count (T-REC and B-RFC), functional leukocyte activity in RTML for FGA and Trichinella larvae antigens, content of circulating immune complexes and complement were determined. Voltaren did not cause delay in adult Trichinella elimination from the intestine of experimental animals, it also did not increase invasion rate at the muscular stage. As compared to the control, T- and B-lymphocyte content and RTML for FGA remained unaltered. Experimental animals show elevated blood complement activity and RTML inhibition of trichinella antigens. The combination of mebendasole and voltaren did not reduce parasitogenic effect. Despite the terms of drug injection, T- and B-lymphocytes count and complement levels in blood were found to increase, as well as the RTML index on FGA and its inhibition of specific antigens as compared with the infected untreated animals.
Raisov
T K
TK
Temirbekov
D A
DA
Arkhipov
G S
GS
Ozeretskovskaia
N N
NN
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood; D003165:Complement System Proteins / Q000032:analysis; D003964:Diaphragm / Q000469:parasitology; D004008:Diclofenac / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000276:immunology; D007421:Intestine, Small / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D013997:Time Factors; D014235:Trichinellosis / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology*
D000936:Antigen-Antibody Complex; D004008:Diclofenac; D008463:Mebendazole; D003165:Complement System Proteins
Izmenenie invazionnogo protsessa i immunnogo otveta khoziaina pri lechenii mebendazolom i vol'tarenom éksperimental'nogo trikhinelleza morskikh svinok.