[Pharmacokinetics of drugs used during the period of cardiac support].
Deep endobronchial instillation of epinephrine (2-5 mg in 5 ml saline, catheter of 50 cm in length), during cardiopulmonary resuscitation in man, results rapidly in efficient blood concentrations, similar to those obtained with i.v. route, but with the additional benefit of a more prolonged effect, due to a slower blood concentration decrease. Despite the large interindividual variations in resulting blood concentrations, also observed with the i.v. route, the endobronchial instillation of lidocaine (5-7 mg.kg-1 in 10 ml saline) results in most cases in blood concentrations located in the therapeutic range. As with epinephrine, the endobronchial route results in a prolonged, infusion-like effect. This can be of benefit for the prevention of recurrent ventricular fibrillation. This study provides further arguments for a more extensive use of the endobronchial route, especially in out-of-hospital resuscitation.
Schüttler
J
J
Institut für Anästhesiologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Venusberg.
D000280:Administration, Inhalation; D000818:Animals; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006323:Heart Arrest / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012151:Resuscitation
D008012:Lidocaine; D004837:Epinephrine
Pharmacocinétique des médicaments utilisés pour la phase de relance cardiaque.