[Inhibition of alfa interferon and ampligen of human immunodeficiency virus (HIV) replication in monocyte-macrophage subpopulations].
Levels of replication of HIV in two different populations of monocyte/macrophages (M/M) at different stages of maturation were evaluated, as well as the antiviral activity of alpha-interferon (alpha-IFN) and Ampligen (an inductor of endogenous production of alpha-IFN). HIV replication was found to be 5-10 times greater in mature than in young M/M. Furthermore, alpha-IFN and Ampligen showed a substantial anti-HIV activity in young M/M, while little effect was achieved in mature M/M. Finally, HIV replication in chronically-infected M/M was not affected by alpha-IFN. These results suggest that alpha-IFN might be useful in combination with other anti-HIV drugs in the therapy of HIV-related disease.
Bergamini
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Dipartimento di Sanità Pubblica, Università di Roma Tor Vergata.
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D000386:AIDS-Related Complex / Q000188:drug therapy; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006678:HIV / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D008264:Macrophages / Q000382:microbiology*; D009000:Monocytes / Q000382:microbiology*; D011070:Poly I-C; D011072:Poly U; D011131:Polyribonucleotides / Q000494:pharmacology* / Q000627:therapeutic use; D012330:RNA, Double-Stranded; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007370:Interferon Type I; D011131:Polyribonucleotides; D012330:RNA, Double-Stranded; D011072:Poly U; C047490:poly(I).poly(c12,U); D011070:Poly I-C
Inibizione da interferon alfa e ampligen della replicazione del virus dell'immunodeficienza umana (HIV) in sottopopolazioni di monocito-macrofagi.