Mechanism of influenza virus transcription inhibition by matrix (M1) protein.
The mechanism by which influenza virus matrix (M1) protein inhibits viral RNA (vRNA) transcription was investigated. Evidence has been generated that M1 protein inhibits the steps of vRNA transcription initiation and reinitiation more effectively than that of RNA chain elongation. The vRNA-associated nucleocapsid protein (NP) appears to be critical for this inhibition, implying that M1 protein binds to the ribonucleoprotein complex (RNP) through NP.
Hankins
R W
RW
Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan.
Nagata
K
K
Kato
A
A
Ishihama
A
A
D002213:Capsid / Q000378:metabolism; D009980:Influenza A virus / Q000235:genetics*; D007700:Kinetics; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D014158:Transcription, Genetic; D014758:Viral Core Proteins / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000378:metabolism*
D012367:RNA, Viral; D012261:Ribonucleoproteins; D014758:Viral Core Proteins; D014763:Viral Matrix Proteins