Cell types and axonal sizes of calcitonin gene-related peptide-containing primary sensory neurons of the rat.
Neurons with immunoreactivity (IR) for calcitonin gene-related peptide (CGRP) in the rat dorsal root ganglia were examined by immunoelectron microscopy. About one-half of the neurons of the L5 dorsal root ganglia of animals treated with colchicine had CGRP-IR, and 40% of these were large neurons of type A. The proximal parts of their peripheral axons were, however, unmyelinated (91%) or thinly myelinated (9%). Thickly myelinated axons observed in the same sections were always devoid of CGRP-IR. The CGRP-IR neurons were various subtypes of type A and B neurons. No specific morphological characteristics were associated with CGRP-IR.
Ishida-Yamamoto
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A
Department of Anatomy II, Osaka University Medical School, Japan.
Senba
E
E
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009475:Neurons, Afferent / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D015740:Calcitonin Gene-Related Peptide