[Oxygen radical production by alveolar macrophages in sarcoidosis in relation to activity status of bronchoalveolar lavage lymphocytes].
Mediators of lymphocytic alveolitis in sarcoidosis are able to activate alveolar macrophages. In sarcoidosis, there is a pre-activation of the alveolar macrophages, which is reflected in an elevated production of O2 by the alveolar macrophages. There is a positive correlation between this radical load in the distal respiration tract and parameters of lymphocytic alveolitis.
Strausz
J
J
III. Medizinische Klinik-Schwerpunkt Pneumologie, Universitätskliniken Mainz.
Müller-Quernheim
J
J
Steppling
H
H
Nagel
M
M
Ferlinz
R
R
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D008171:Lung Diseases / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D010101:Oxygen Consumption / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology*
D005609:Free Radicals
Sauerstoffradikalproduktion durch Alveolarmakrophagen (AM) bei Sarkoidose in Abhängigkeit des Aktivitätsstatus der bronchoalveolären Lavage Lymphozyten.