Effect of N-acetylchitohexaose against Candida albicans infection of tumor-bearing mice.
A water-soluble oligosaccharide, N-acetylchitohexaose (NACOS-6), was able to enhance the protective effect against Candida albicans infection in mice during the early phase of tumor-bearing. A significant decrease in the number of C. albicans cells in the kidneys of NACOS-6-treated tumor-bearing mice was observed 8 days after the fungal infection, or 15 days after the tumor transplantation. The candidacidal activity of polymorphonuclear leukocytes from NACOS-6-treated tumor-bearing mice did not differ from that of NACOS-6-untreated tumor-bearing mice. On the other hand, the candidacidal activities of both macrophages and T lymphocytes increased following administration of NACOS-6 in the early phase of tumor-bearing. The culture supernatant of T lymphocytes from NACOS-6-treated tumor-bearing mice also potentiated the candidacidal activity of casein-induced macrophages. An enhancement of natural killer cell activity of splenic lymphocytes obtained from NACOS-6-treated tumor-bearing mice was also observed.
Kobayashi
M
M
Department of Microbiology, Tohoku College of Pharmacy, Miyagi.
Watanabe
T
T
Suzuki
S
S
Suzuki
M
M
D000818:Animals; D002177:Candidiasis / Q000150:complications / Q000517:prevention & control*; D015169:Colony Count, Microbial; D007668:Kidney / Q000187:drug effects / Q000382:microbiology; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000150:complications*; D009844:Oligosaccharides / Q000627:therapeutic use*
D009844:Oligosaccharides; C056529:N-acetylchitohexaose