[The inhibitory effect of ascorbic acid on the estrogen-stimulated promotion of uterine sarcoma development in mice].
The administration of estradiol propionate after the discontinuation of 1,2-dimethylhydrazine (DMH) treatment increased the incidence of uterine sarcoma in CBA mice from 32.5 (DMH alone) to 62.5%. The addition of the ascorbic acid (0.3% solution in drinking water) to estradiol propionate was followed by a decrease in the tumor incidence to 35%, i. e. the acid levelled the promoting effect of estradiol propionate almost completely. Sodium ascorbate did not share that effect. Mechanisms underlying the antiestrogenic effect of the ascorbic acid are discussed.
Trukhanova
L S
LS
Parfenov
Iu D
IuD
Turusov
V S
VS
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002273:Carcinogens; D004127:Dimethylhydrazines; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D004965:Estrogen Antagonists; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*
D002273:Carcinogens; D004127:Dimethylhydrazines; D004965:Estrogen Antagonists; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate; D001205:Ascorbic Acid
Tormoziashchiĭ éffekt askorbinovoĭ kisloty na stimulirovannuiu éstrogenom promotsiiu sarkomogeneza matki u mysheĭ.