title: Impaired active avoidance responding in rats selectively bred for increased cholinergic function.
abstract: It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.
authors.affiliation: Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill 27514.
authors.forename: D H
authors.initials: DH
authors.lastname: Overstreet
authors.forename: A H
authors.initials: AH
authors.lastname: Rezvani
authors.forename: D S
authors.initials: DS
authors.lastname: Janowsky
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology; D002799:Cholinergic Fibers / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000235:genetics*; D012641:Selection, Genetic; D013045:Species Specificity
chemical_list: D011950:Receptors, Cholinergic