title: [The use of the triphasic contraceptive preparation trisiston for therapeutic purposes].
abstract: After a brief review of the qualities of the new triphasic contraceptive preparation Trisistone and some of its advantages in comparison with the other combined contraceptive drugs the authors report on the results from the first study, carried out in our country, on the therapeutic effect of Trisistone. Thirty-eight women with various gynecological diseases were treated. The largest group was that of women with irregular bleedings. In this group the effect was not good in all women. It was found that Trisistone had limited possibilities to control irregular uterine bleedings, which most probably was connected with its comparatively low dose of steroid hormones. The side effects were comparatively slight and not quite frequently. The most frequent side effect was the occurrence of irregular bleeding in 9.5% of the treated women. The state without any side effects was improved in 30.1% of the patients. Best results were found in women with postcastration syndrome, hypoestrogenism and congenital anomalies in the development of ovaries--primary ovarian dysgenesis. Trisistone is especially suitable for substituted treatment in women with ovarian hormonal deficit.
authors.forename: D
authors.initials: D
authors.lastname: Vasilev
authors.forename: M
authors.initials: M
authors.lastname: Katsarova
authors.forename: I
authors.initials: I
authors.lastname: Dikov
authors.forename: E
authors.initials: E
authors.lastname: Rachev
mesh_terms: D000328:Adult; D003271:Contraceptive Agents, Female / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009644:Norgestrel / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003271:Contraceptive Agents, Female; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination
vernacular_title: Prilozhenie na trifazniia kontratseptiven preparat trisiston za lechebni tseli.