Synthesis and estrogen activity screening of some new D-secoestrone derivatives.
Five new D-secoestrone derivatives were synthesized, starting from 3-methoxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile. Newly synthesized compounds showed a complete loss of estrogenic activity.
Petrović
J A
JA
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
Pejanović
V M
VM
Miljković
D A
DA
Hranisavljević
J T
JT
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012632:Secosteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects / Q000254:growth & development
D004967:Estrogens; D012632:Secosteroids; D004970:Estrone