[The combined action of glucocorticoid hormones and interleukin-1 on the development of an immune response].
The effect of interleukin-I (IL-I) on glucocorticoid-induced inhibition of the immune response and reactions of cyclic nucleotides to antigen was studied on a model with the use of purified IL-I preparation. Hydrocortisone (HC) in the applied dose caused suppression of the immune response and sharp inhibition of antigen-induced reactions--cAMP in 10 minutes and cGMP on the 6th day after immunization. IL-I administered 10 minutes prior to HC and before immunization prevented the immunosuppressive effect of HC completely. Control administration of heated IL-I and in inactive fraction of the preparation failed to produce a similar effect. IL-I injected 10 minutes after HC also inhibited immunosuppression.
Lesnikova
M P
MP
Rybakina
E R
ER
Kozinets
I A
IA
Shkhinek
E K
EK
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006854:Hydrocortisone / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D007114:Immunization; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009712:Nucleotides, Cyclic / Q000276:immunology; D011817:Rabbits; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D007375:Interleukin-1; D009712:Nucleotides, Cyclic; D006854:Hydrocortisone
Sochetannoe deĭstvie gliukokortikoidnykh gormonov i interleĭkina-1 na razvitie immunnogo otveta.