Variables of patient-controlled analgesia. 3: Test of an infusion-demand system using alfentanil.
Patient-controlled infusion-demand analgesia was studied using alfentanil. We were unable to identify an optimal dose and administration rate; doses required range from 100 to 900 micrograms alfentanil. The mean concentration of alfentanil in blood associated with return of pain (i.e. immediately before demand) was 58 ng/ml on day 1 and 37 ng/ml on day 2. This difference was despite similar drug consumption on both days.
Owen
H
H
Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, Adelaide, South Australia.
Brose
W G
WG
Plummer
J L
JL
Mather
L E
LE
D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D012646:Self Administration; D013997:Time Factors
D015760:Alfentanil