[The anti-arrhythmia properties of bonnecor metabolites].
The experiments on the model of aconitine-induced arrhythmia in anesthetized rats and awake dogs with cardiac rhythm disorders caused by the coronary artery occlusion showed that all four metabolites of bonnecor possessed the antiarrhythmic activity. Metabolite 4 proved to be the most active on both models of cardiac rhythm disorders.
Grigor'eva
E K
EK
Poppe
H
H
Tolmacheva
E A
EA
Krasnykh
L M
LM
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D003984:Dibenzazepines / Q000378:metabolism / Q000627:therapeutic use*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D051381:Rats; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine; D000157:Aconitine
Antiaritmicheskie svoĭstva metabolitov bonnekora.