title: Multiple congenital contractures (MCC) and cleft palate induced in goats by ingestion of piperidine alkaloid-containing plants: reduction in fetal movement as the probable cause.
abstract: Fetal movement, observed by ultrasound imaging, was significantly reduced (P less than or equal to 0.001) in pregnant goats gavaged with Conium seed and Nicotiana glauca and temporarily reduced with fresh Conium plant. Conium seed and Nicotiana glauca induced cleft palate and multiple congenital contractures in 100% of the kids born to pregnant goats gavaged with these plants. Multiple congenital contractures included torticollis, scoliosis, lordosis, arthrogryposis, rib cage anomalies, over extension, and flexure and rigidity of the joints. However, in goats gavaged with fresh Conium plant, fetal movement was inhibited for only about 5 hours after each individual dosage and gradually returned to control levels 12 hours after dosing. Fetal malformations in this group were limited from modest to moderate contractures of the front limbs, which resolved by 8-10 weeks post partum. No cleft palates were induced. Fetal movement was not inhibited in goats fed Lupinus caudatus and no cleft palates or multiple congenital contractures were induced in their offspring. The duration of the reduction in fetal movement appears to be an important factor in the severity and permanence of the deformities, particularly with cleft palate, spinal column defects, and severe joint deviation and fixation.
authors.affiliation: USDA/ARS/Poisonous Plant Research Laboratory, Logan, Utah.
authors.forename: K E
authors.initials: KE
authors.lastname: Panter
authors.forename: T D
authors.initials: TD
authors.lastname: Bunch
authors.forename: R F
authors.initials: RF
authors.lastname: Keeler
authors.forename: D V
authors.initials: DV
authors.lastname: Sisson
authors.forename: R J
authors.initials: RJ
authors.lastname: Callan
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000209:etiology*; D000284:Administration, Oral; D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced*; D005260:Female; D005324:Fetal Movement / Q000187:drug effects*; D006041:Goats; D008431:Maternal-Fetal Exchange; D010880:Piperidines / Q000633:toxicity*; D011247:Pregnancy
chemical_list: D000470:Alkaloids; D010880:Piperidines