title: Amphetamine lowers extracellular GABA concentration in the ventral pallidum.
abstract: In vivo dialysis was performed in the ventral pallidum of the conscious rat, and extracellular levels of gamma-aminobutyric acid (GABA) measured. Forty minutes following peripheral administration of amphetamine (2.0 mg/kg, s.c.) the extracellular concentration of GABA was significantly reduced, in parallel with a significant elevation in motor activity. These data indicate that a decline in GABA transmission in the ventral pallidum may be important in the initiation of amphetamine-induced motor activity.
authors.affiliation: Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520.
authors.forename: A
authors.initials: A
authors.lastname: Bourdelais
authors.forename: P W
authors.initials: PW
authors.lastname: Kalivas
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D000661:Amphetamine