Neutrophil functions in lead-exposed workers.
Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemiluminescence was found to be slightly but not significantly altered in exposed workers. In contrast, chemotaxis using the agarose technique was significantly depressed. These results are in agreement with previous in-vitro findings. A further assessment of clinical consequences is warranted.
Bergeret
A
A
Institut Universitaire de Médecine du Travail, Lyon, France.
Pouget
E
E
Tedone
R
R
Meygret
T
T
Cadot
R
R
Descotes
J
J
D000622:Aminolevulinic Acid / Q000097:blood; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007855:Lead Poisoning / Q000097:blood*; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced; D010587:Phagocytosis / Q000187:drug effects
D006454:Hemoglobins; D000622:Aminolevulinic Acid