Evaluation of indicators of erythropoiesis stimulated by recombinant human erythropoietin in renal anemia.
Recombinant human erythropoietin (rh-EPO) was administered to 11 anemic children with end-stage renal disease who were undergoing hemodialysis. Hematocrit (Hct), absolute reticulocyte count (retics), creatine concentration of red cells and erythrocyte density test (EDT) were chosen as indicators of rh-EPO effect on erythropoiesis. In the present report the first 9 weeks shall be presented in which all patients received an identical dosage of rh-EPO per kg body weight. The pre-EPO values of retics, creatine and EDT varied considerably. In 10 patients the Hct increased to 0.30 after 9 weeks of rh-EPO treatment. Retics and creatine rose in all cases above the normal range, rates of increase and maximal values differed. Retics, creatine and EDT respond faster to rh-EPO than Hct. Retics and creatine seem to be equally good indicators of rh-EPO stimulated erythropoiesis. The EDT showed an increase only up to the 4th week.
Schmidt
G
G
Children's Hospital, Berlin, GDR.
Stamminger
G
G
Daniel
A
A
Gross
J
J
Syllm-Rapoport
I
I
Lun
A
A
Zoellner
K
K
D000293:Adolescent; D000740:Anemia / Q000150:complications / Q000378:metabolism*; D002648:Child; D003401:Creatine / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D006435:Renal Dialysis
D011994:Recombinant Proteins; D004921:Erythropoietin; D003401:Creatine