Tropic effect of dexamethasone on goldfish melanocytoma cells: induction of calcium-dependent but protein synthesis-independent morphological changes.
Treatment of melanocytoma cells of goldfish origin with dexamethasone leads to rapid morphological changes, flattening of cell body and extension of dendrites. This effect is independent of protein synthesis but requires the presence of extracellular calcium, indicating that it is a "tropic effect" distinct from the typical "trophic effects" of steroid hormones that involve de novo protein synthesis.
Shih
Y L
YL
Graduate Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taiwan, Republic of China.
Chou
S C
SC
Chi
C W
CW
Tchen
T T
TT
Lo
S J
SJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D003530:Cyprinidae / Q000033:anatomy & histology*; D003712:Dendrites / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D006054:Goldfish / Q000033:anatomy & histology*; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology*; D011506:Proteins / Q000378:metabolism; D015290:Second Messenger Systems; D013997:Time Factors
D011506:Proteins; D003907:Dexamethasone; D002118:Calcium