The response of rat adrenal zona fasciculata and zona reticularis to oxytocin treatment.
The response of the adrenal zona fasciculata (ZF) and zona reticularis (ZR) to oxytocin (OT) was examined in male rats using a stereological method. The 10-day administration of 0.25 IU OT/100 g daily caused an enlargement of ZF due to cell hypertrophy associated with striking lipid accumulation. The volume of ZR was decreased, this change being the consequence of the reduced cell population. The possible site of OT action is discussed.
Plećas
B
B
Department of Physiology, Faculty of Pharmacy, Belgrade/Yugoslavia.
Hristić
M
M
Jovović
D
D
Popović
A
A
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015383:Zona Fasciculata / Q000166:cytology / Q000187:drug effects*; D015385:Zona Reticularis / Q000166:cytology / Q000187:drug effects*
D010121:Oxytocin; D006854:Hydrocortisone