Identification of transcription stop sites at the 5' and 3' ends of the murine adenosine deaminase gene.
We report here the identification and nucleotide sequence of two transcription termination regions associated with the murine adenosine deaminase gene. One region is situated within or very near exon one and in mouse fibroblasts accounts for more than a 50-fold drop in the abundance of nascent transcripts. This termination region is believed to be involved in the regulation of adenosine deaminase gene transcription. The other termination region is located approximately 3.5 kilobases beyond the major polyadenylation site and defines the 3' boundary of the adenosine deaminase transcription unit.
Maa
M C
MC
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030.
Chinsky
J M
JM
Ramamurthy
V
V
Martin
B D
BD
Kellems
R E
RE
D000243:Adenosine Deaminase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D005091:Exons; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D051379:Mice; D008969:Molecular Sequence Data; D009700:Nucleoside Deaminases / Q000235:genetics*; D010920:Placenta / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D013728:Terminator Regions, Genetic; D014158:Transcription, Genetic
D012333:RNA, Messenger; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase