Microencapsulation using poly(DL-lactic acid). IV: Effect of storage on the microcapsule characteristics.
Poly (DL-lactic acid) [DL-PLA] microcapsules containing phenobarbitone were prepared using a W/O emulsion method. Microcapsules of nominal C : P ratio, 1 : 2 and 1 : 3 using three different molecular weight polymers, 20,500, 13,300 and 5,200 were investigated to study the effect of storage conditions on the microcapsule properties. All microcapsules were stored under desiccated condition at temperatures of 4 degrees, 20 degrees and 37 degrees C for six months. Storage temperatures of 4 degrees and 20 degrees C did not cause appreciable changes in the release rate after storage. Microcapsules stored at 37 degrees C showed an annealing effect, causing shrinkage of microcapsules, and lowering of the release rate after storage for six months. The microcapsules prepared from low molecular weight DL-PLA fused completely whilst stored at 37 degrees C and the other two high molecular DL-PLA also showed some aggregation. There were insignificant variations in the mean microcapsule diameter during storage. The phenobarbitone content of the microcapsules was also unchanged.
Jalil
R
R
Chelsea Department of Pharmacy, King's College London, University of London.
Nixon
J R
JR
D003692:Delayed-Action Preparations; D004355:Drug Stability; D004356:Drug Storage; D007773:Lactates; D019344:Lactic Acid; D010316:Particle Size; D010634:Phenobarbital / Q000493:pharmacokinetics*; D011091:Polyesters; D011108:Polymers; D013696:Temperature
D003692:Delayed-Action Preparations; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D010634:Phenobarbital