title: Three related near-haploid clones in a primary endometrioid carcinoma of the ovary.
abstract: We report the cytogenetic findings in a primary endometrioid carcinoma of the ovary from a 29-year-old woman. Three clones with counts of 30, 29, and 27 chromosomes were observed. The predominant clone had 29 chromosomes and the following karyotype: 29, X, -X, -3, -3, +der(3)ins(3;?) (q21;?), -4, -5, -6, -8, -9, -11, -13, -14, -15, -16, -17, -18, -19, -21, -22, +mar. The clone with 30 chromosomes had an additional marker in the form of a minute chromosome, and the clone with 27 chromosomes was monosomic for chromosomes 12 and 20 also. Interestingly, there was no nullisomy of any of the chromosomes.
authors.affiliation: Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
authors.forename: C
authors.initials: C
authors.lastname: Sreekantaiah
authors.forename: K
authors.initials: K
authors.lastname: Crickard
authors.forename: U
authors.initials: U
authors.lastname: Crickard
authors.forename: M
authors.initials: M
authors.lastname: Yoonessi
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology