[Comparison of the distribution sites and diagnostic significance of three antibodies as the melanoma markers].
S-100 and its subunits have subsequently been shown to be present in a wide variety of human neoplastic tissues. Three antibodies, monoclonal S-100, polyclonal S-100 and HMB-45, were used for comparison of the positive rates of different sites of melanomas. The results showed that HMB-45 was positive for those melanoma cells in epidermis and negative for those in dermis. Monoclonal S-100 was negative for melanoma cells in epidermis and positive for those in dermis. They are useful for the diagnosis of melanoma in surgical pathology.
Ji
X L
XL
Department of Pathology, Chinese PLA General Hospital.
Li
W H
WH
D000911:Antibodies, Monoclonal / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D004817:Epidermis / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000175:diagnosis*; D009418:S100 Proteins / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D009418:S100 Proteins