[The protective properties of different Legionella antigens in experimental Legionella infection].
The protective properties of Legionella antigenic preparations were studied on guinea pigs with experimental Legionella infection. Preliminary immunization of guinea pigs with serotypic antigen, cytolysin, as well as live or formalin-treated Legionella cells, did not protect the animals from the subsequent aerogenic infection with 10(5) colony-forming units of virulent L. pneumophila. Immunization with the main outer membrane protein ensured the survival of 70% of the animals and inhibited the proliferation of the infective agent in the lungs of guinea pigs subjected to aerogenic infection with 10(5) colony-forming units of virulent L. pneumophila. The data obtained in this study indicate that the main outer membrane protein of L. pneumophila is capable of stimulating protective immunity.
Tartakovskiĭ
I S
IS
Zubashev
I K
IK
Koniukhov
V F
VF
Petrosov
V V
VV
Eruslanov
B V
BV
Nebozhina
L V
LV
Rodionov
A V
AV
Dmitriev
B A
BA
Suchkov
Iu G
IuG
Pronin
A V
AV
D000336:Aerosols; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D007875:Legionella / Q000276:immunology* / Q000472:pathogenicity; D007877:Legionnaires' Disease / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D008168:Lung / Q000382:microbiology; D012692:Serial Passage; D013997:Time Factors; D014774:Virulence
D000336:Aerosols; D000942:Antigens, Bacterial
Izuchenie protektivnykh svoĭstv razlichnykh antigenov legionell pri éksperimental'noĭ legionelleznoĭ infektsii.