title: Neuroendocrine differentiation in a case of acinic cell carcinoma of the parotid gland.
abstract: We report a case of acinic cell carcinoma of the parotid gland with neuroendocrine differentiation. Light microscopically, the tumor appeared as clear cell-type acinic cell carcinoma. In addition, the tumor showed neurosecretory features such as Grimelius positivity and the presence of neurosecretory granules by electron microscopy. We suggest that a tumor cell arising from a stem cell can show simultaneous differentiation to both neuroendocrine and acinic cells.
authors.affiliation: Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Kakudo
authors.forename: I
authors.initials: I
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Horiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Osamura
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology* / Q000648:ultrastructure; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure