A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.
The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. The method is illustrated by the study of apolipoprotein and cholesterol levels in individuals from a large family that had many members diagnosed with coronary heart disease.
Amos
C I
CI
Family Studies Section, National Cancer Institute, Bethesda, MD 20892.
Elston
R C
RC
Bonney
G E
GE
Keats
B J
BJ
Berenson
G S
GS
D001053:Apolipoproteins / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000235:genetics*; D008957:Models, Genetic; D015999:Multivariate Analysis; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005819:Genetic Markers; D008074:Lipoproteins