[Effects of intragastric and intrajejunal ethanol administration on canine pancreatic exocrine secretion and duodenal pH].
The effect of ethanol on pancreatic exocrine secretion and intraduodenal pH was investigated in 3 dogs, after making pancreatic, gastric, and jejunal fistula. After intragastric and intrajejunal administration of ethanol the intraduodenal pH went down and pancreatic juice, pancreatic bicarbonate output was increased. The integrated value of pancreatic juice, pancreatic bicarbonate and pancreatic protein output was greater in case of intrajejunal administration rather than intragastric administration of the ethanol. After intragastric and intrajejunal administration of the ethanol the plasma concentration of CCK was unchanged. The decrease of intraduodenal pH and increase of pancreatic exocrine secretion was though be mainly due to the secondary action of gastric acid secretion stimulated by ethanol.
Tsai
J
J
First Department of Surgery, Tohoku University School of Medicine, Sendai.
Miyashita
E
E
Kobari
M
M
Matsuno
S
S
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D007583:Jejunum; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000378:metabolism; D013270:Stomach
D001639:Bicarbonates; D000431:Ethanol; D010191:Pancreatic Polypeptide