[The efficacy of dimethyl sulfoxide in secondary amyloidosis in patients with rheumatic diseases].
The author studied the efficacy of dimethylsulfoxide (DMSO) in 26 patients (22 patients with rheumatoid arthritis, 3--with Bechterew's disease, I--with psoriatic arthropathy) with recurrent amyloidosis with predominant affection of the kidneys. The control group was given colchicine (15 patients with rheumatoid arthritis, one patient with Bechterew's disease and one with psoriatic arthropathy). It has been shown that DMSO given in a daily dose much smaller than usually recommended provides a therapeutic effect (improves the function of the kidneys) already in 1-1.5 months of peroral administration irrespective of the presence of the signs of renal insufficiency; it exceeds the effect of colchicine. DMSO is well tolerated.
Murav'ev
Iu V
IuV
D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000150:complications*; D003078:Colchicine / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D003078:Colchicine; D004121:Dimethyl Sulfoxide
Effektivnost' dimetilsul'foksida pri vtorichnom amiloidoze u bol'nykh s revmaticheskimi zabolevaniiami.