title: Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
abstract: A series of 1-[1-arylcyclohexyl]-1,2,3,6-tetrahydropyridines were prepared by the reaction between 1-(1-cyanocyclohexyl)-1,2,3,6-tetrahydropyridine (1) and an appropriately substituted Grignard reagent. The resulting compounds were tested for their phencyclidine binding site affinities. Selected compounds were then tested for their ability to produce ketamine appropriate responding in monkeys and/or to show neuroprotective effects in a baby rat hypoxia/ischemia model. While it was found that binding site affinity correlated well with discriminative stimulus effects, it was found to be a poor indicator of neuroprotective efficacy within this series.
authors.affiliation: Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: A
authors.initials: A
authors.lastname: Thurkauf
authors.forename: B
authors.initials: B
authors.lastname: de Costa
authors.forename: M V
authors.initials: MV
authors.lastname: Mattson
authors.forename: C P
authors.initials: CP
authors.lastname: France
authors.forename: M T
authors.initials: MT
authors.lastname: Price
authors.forename: J W
authors.initials: JW
authors.lastname: Olney
authors.forename: J H
authors.initials: JH
authors.lastname: Woods
authors.forename: A E
authors.initials: AE
authors.lastname: Jacobson
authors.forename: K C
authors.initials: KC
authors.lastname: Rice
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004192:Discrimination, Psychological / Q000187:drug effects; D000860:Hypoxia / Q000517:prevention & control; D007511:Ischemia / Q000517:prevention & control*; D007649:Ketamine; D008253:Macaca mulatta; D015394:Molecular Structure; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D011725:Pyridines; D007649:Ketamine; C012058:tenocyclidine; D010622:Phencyclidine