title: The lymphocyte response to nickel salt in patients with orthopedic implants.
abstract: In this pilot study, 14 patients with different symptoms and signs in relation to orthopedic implants were compared with 12 asymptomatic patients to determine the in vitro lymphocyte response to nickel sulfate. We conclude that nickel allergy may explain some, but not most, of the local and generalized symptoms associated with orthopedic implants.
authors.affiliation: Department of Orthopedics, Danderyd Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Bjurholm
authors.forename: N A
authors.initials: NA
authors.lastname: al-Tawil
authors.forename: J A
authors.initials: JA
authors.lastname: Marcusson
authors.forename: P
authors.initials: P
authors.lastname: Netz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007509:Irritants / Q000009:adverse effects* / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects* / Q000494:pharmacology; D010865:Pilot Projects; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D007509:Irritants; C029938:nickel sulfate; D009532:Nickel