title: Remote lateralized changes in cortical [3H]spiperone binding following focal frontal cortex lesions in the rat.
abstract: Positron emission tomography (PET) studies in stroke patients have shown that right hemisphere lesions lead to increases in ipsilateral (compared to contralateral) cortical S2-serotonin receptors, while left hemisphere lesions do not. To assess whether similar lateralized changes in cortical S2-receptors could be demonstrated in response to brain injury in the rat, [3H]spiperone (SP) autoradiography was performed 30 days after unilateral cortical suction lesions. Right lesions produced bilateral increases in total SP binding in frontal cortex (excluding the lesion site): 48% greater than after left lesions, and 23% greater than shams. Left lesions led to bilateral decreases in S2-receptors in the frontal and perirhinal cortex and these decreases were asymmetric. There was a greater decrease in the hemisphere contralateral to the lesion than in the side with the lesion. Frontal S2-receptor binding was positively correlated with running wheel activity in all animals with lesions, regardless of lesion side. These results suggest that there is a lateralized receptor and behavioral response to focal injury in rats, analogous to that previously observed in humans.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
authors.forename: H S
authors.initials: HS
authors.lastname: Mayberg
authors.forename: T H
authors.initials: TH
authors.lastname: Moran
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D005625:Frontal Lobe / Q000378:metabolism / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism* / Q000502:physiology; D013134:Spiperone / Q000378:metabolism*
chemical_list: D011985:Receptors, Serotonin; D013134:Spiperone