title: Dominance of memory over naive T cells in contact dermatitis is due to differential tissue immigration.
abstract: CD4+ T cells include a naive (CD4-, CD45RO-, CD29-, CD45RA+) as well as a memory subpopulation (CD4+, CD45RO+, CD29+, CD45RA-). These subpopulations represent different stages in T-cell development and function. Recently, it has been shown that inflammatory and neoplastic CD4+ T-cell infiltrates are dominated by the memory subpopulation, whereas both subpopulations are about the same size in the peripheral blood. This was thought to be the result of in situ maturation of naive into memory T cells. We analysed early positive patch-test reactions 1-2 days after antigen challenge and found that most of the CD4+ T cells that had freshly immigrated into the tissue carried the memory phenotype. Their preferential migration may be mediated by at least five adhesion molecules expressed on their cell surface. This observation has important pathogenetic implications, since memory T cells can be rapidly activated by antigens and secrete a wide variety of pro-inflammatory cytokines.
authors.affiliation: Department of Dermatology, University of Kiel, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Sterry
authors.forename: S
authors.initials: S
authors.lastname: Bruhn
authors.forename: N
authors.initials: N
authors.lastname: Künne
authors.forename: B
authors.initials: B
authors.lastname: Lichtenberg
authors.forename: K
authors.initials: K
authors.lastname: Weber-Matthiesen
authors.forename: J
authors.initials: J
authors.lastname: Brasch
authors.forename: V
authors.initials: V
authors.lastname: Mielke
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D003877:Dermatitis, Contact / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008213:Lymphocyte Activation; D010641:Phenotype; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D015704:CD4 Antigens