[A spectral analysis and mathematical modelling of the brain electrical activity in normal rats and in genetically conditioned convulsibility].
Spectral signs of genetically conditioned convulsibility of rats of the Krushinskiĭ-Molodkina (KM) strain were determined when studying the background electrical brain activity. These signs were: an increase of the delta-activity power in motor and visual cortical zones; considerable increase of the hippocampal potential power; weakening of the caudate nucleus potential power. Spectra of biopotentials being approximated by theoretical spectral function, model parameters simulating physiological characteristics of neural networks were estimated (an inverse problem of modelling). Spectral signs of convulsibility were shown to reflect changes in properties of the neural network. On the basis of calculations it is supposed that genetically determined convulsibility of KM rats results from weakening of inhibitory functions of the caudate nucleus as well as from increased excitability (reactivity) of hippocampal and neocortical neurons.
Medvedev
A V
AV
Frolov
A A
AA
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000502:physiology*; D004198:Disease Susceptibility / Q000503:physiopathology; D007395:Interneurons / Q000502:physiology; D008297:Male; D008433:Mathematics; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology
Spektral'nyĭ analiz i matematicheskoe modelirovanie élektricheskoĭ aktivnosti mozga krys v norme i pri geneticheski obuslovlennoĭ sudorozhnoĭ gotovnosti.