Anti-glomerular basement membrane (GBM) glomerulonephritis in the mouse: development of disease and cell proliferation.
In a mouse model of anti-glomerular basement membrane (GBM) glomerulonephritis, associated with the nephrotic syndrome, a wide range of morphological and proliferative responses was seen in the renal corpuscle, at 6 days. The severity of the damage could be assessed by measuring the average daily weight gain between days 0 and 3 (DWG) of the animal. Those animals with a high DWG showed capsular proliferation, whereas animals with a low DWG showed predominantly tuft cell proliferation. Capsular cell birth rate increased with DWG whilst tuft cell birth rate was negatively related. A computer simulation suggests that the results are compatible with the induction of successive but overlapping waves of tuft and capsular cell proliferation.
Wheeler
J
J
Department of Microbiology, University of Newcastle upon Tyne, UK.
Morley
A R
AR
Appleton
D R
DR
D000818:Animals; D001485:Basement Membrane / Q000276:immunology; D002455:Cell Division; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D008940:Mitotic Index
D007074:Immunoglobulin G