Fibroblast colony-forming cells with high sensitivity to serum mitogen(s) exist in bone marrow of patients with chronic myelocytic leukemia.
Marrow fibroblast colony formation was studied in patients with myeloproliferative disorders, using human serum or platelet-derived growth factor plus plasma-derived serum as growth-stimulating factors. Colony numbers negatively correlated with the patient's age, but were not different from those of controls. However, both maximum and average cell numbers per colony were significantly increased in patients with chronic myelocytic leukemia (CML) as compared to controls. These results suggest that fibroblast colony-forming cells with high sensitivity to human serum mitogen(s) exist in a CML bone marrow. These may possibly be involved in one of the mechanism concerned with promoting fibrosis in this disease.
Kimura
A
A
Department of Internal Medicine, Hiroshima University, Japan.
Katoh
O
O
Hyodo
H
H
Kusumi
S
S
Kuramoto
A
A
D000328:Adult; D000368:Aged; D001790:Blood Physiological Phenomena; D001853:Bone Marrow / Q000473:pathology*; D002452:Cell Count / Q000187:drug effects; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008875:Middle Aged; D008934:Mitogens / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D013234:Stem Cells / Q000473:pathology*
D008934:Mitogens; D010982:Platelet-Derived Growth Factor