A cyanide-aldehyde complex inhibits bacterial luciferase.
Cyanide at high (millimolar) concentrations inhibited in the in vitro Vibrio harveyi luciferase reaction. Cyanide reacted with free aldehyde to form an inhibitor. Inhibitor formation was accelerated by alkaline conditions and bovine serum albumin.
Makemson
J C
JC
Department of Biological Science, Florida International University, University Park, Miami 33199.
D000447:Aldehydes / Q000494:pharmacology*; D003486:Cyanides / Q000494:pharmacology*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008156:Luciferases / Q000037:antagonists & inhibitors*; D014733:Vibrio / Q000201:enzymology*
D000447:Aldehydes; D003486:Cyanides; C021170:decanaldehyde; D008156:Luciferases