title: Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens.
abstract: In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.
authors.affiliation: Department of Thoracic Medicine, Dudley Road Hospital, Birmingham.
authors.forename: D R
authors.initials: DR
authors.lastname: Baldwin
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: J P
authors.initials: JP
authors.lastname: Ashby
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: D
authors.initials: D
authors.lastname: Honeybourne
mesh_terms: D000284:Administration, Oral; D001980:Bronchi / Q000032:analysis*; D020682:Cefixime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D004334:Drug Administration Schedule; D006801:Humans; D009092:Mucous Membrane / Q000032:analysis; D013183:Sputum / Q000032:analysis*
chemical_list: D020682:Cefixime; D002439:Cefotaxime