[The effect of the plasma of patients with asthma of physical effort on the energy state of the lymphocytes].
The effect of the plasma obtained before and after graded submaximal exercise was examined in 10 bronchial asthma patients with the syndrome of asthma of physical effort (APE) by means of fluorescent exploration using the cation probe 4-(p-demethylaminostyryl)-1-methylpyridinum and rat thymocytes as a test system. Four normal donors and five bronchial asthma patients without the APE syndrome were used as control. The plasma of patients with the APE syndrome, obtained after physical exercise, brought about a decrease of the number of fluorescent cells. In APE patients, the coefficient of the drop of thymocyte fluorescence amounted to 0.65 +/- 0.04, that in the control group to 1.1 +/- 0.08 (p less than 0.01). It is assumed that after physical exercise in the plasma of APE patients, there may occur factor depolarizing the membrane of thymocytes, which is likely to play a substantial role in the pathogenesis of the afterload bronchospasm.
Didkovskiĭ
N A
NA
Kosnikov
V V
VV
Reshetova
N V
NV
Treskunov
V K
VK
Dobretsov
G E
GE
Evseev
N G
NG
D000328:Adult; D000818:Animals; D001249:Asthma / Q000097:blood*; D001250:Asthma, Exercise-Induced / Q000097:blood*; D001986:Bronchial Spasm / Q000097:blood; D002462:Cell Membrane / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000502:physiology*; D011726:Pyridinium Compounds; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects*
C032315:4-(4-dimethylaminostyryl)-1-methylpyridinium; D005456:Fluorescent Dyes; D011726:Pyridinium Compounds
Vliianie plazmy bol'nykh astmoĭ fizicheskogo napriazheniia na énergeticheskoe sostoianie limfotsitov.