Tissue contents and urinary excretion of taurine after administration of L-cysteine and L-2-oxothiazolidine-4-carboxylate to rats.
Tissue contents and urinary excretion of taurine were studied in rats after the administration of L-cysteine and its derivatives. Average taurine content in the liver of rats fed a 25% casein diet for 7 days increased 2-fold 2h after the intraperitoneal administration of 5 mmol of L-cysteine per kg of body weight, whereas that in rats fed a 5% casein diet for 2 days increased only slightly. The difference in the liver taurine contents between these two groups was discussed in relation to cysteine dioxygenase. Taurine contents in the heart, brain and blood did not differ significantly between these two groups or between the control and the group of rats which received L-cysteine. The increase in liver taurine concentrations after L-cysteine administration was much higher than that after L-cystine administration, suggesting a difference in their absorption. The intraperitoneal administration of 5 mmol/kg of L-2-oxothiazolidine-4-carboxylate (OTCA) resulted in a 3-fold increase in liver taurine content. The average increase in taurine excretion in the 24-h urine after OTCA administration corresponded to about 6.0% and that in the next 24-h urine to about 2.6% of OTCA administered, suggesting that nearly 10% of OTCA was metabolized to taurine and excreted in the urine.
Taguchi
T
T
Department of Biochemistry, Okayama University Medical School, Japan.
Akagi
R
R
Ubuka
T
T
D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D003545:Cysteine / Q000493:pharmacokinetics*; D050558:Cysteine Dioxygenase; D003553:Cystine / Q000493:pharmacokinetics; D004044:Dietary Proteins / Q000008:administration & dosage; D049308:Dioxygenases; D007274:Injections, Intraperitoneal; D008099:Liver / Q000032:analysis; D008297:Male; D010105:Oxygenases / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D013844:Thiazoles / Q000493:pharmacokinetics*; D053778:Thiazolidines; D014018:Tissue Distribution
D002364:Caseins; D004044:Dietary Proteins; D013844:Thiazoles; D053778:Thiazolidines; D013654:Taurine; D003553:Cystine; C003949:hypotaurine; D010105:Oxygenases; D049308:Dioxygenases; D050558:Cysteine Dioxygenase; D003545:Cysteine; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid