Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue.
Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.
Elfving
P
P
Department of Urology, University Hospital, Lund, Sweden.
Cigudosa
J C
JC
Lundgren
R
R
Limon
J
J
Mandahl
N
N
Kristoffersson
U
U
Heim
S
S
Mitelman
F
F
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D007668:Kidney / Q000166:cytology; D008297:Male; D014314:Trisomy; D014998:Y Chromosome
D014408:Biomarkers, Tumor