Adrenal adenoma with excess secretion of corticosterone and 18-hydroxycorticosterone.
A 64-year-old man with sudden onset of quadriplegia due to marked hypokalemia was referred to our clinic with suppressed plasma renin activity in the presence of a low aldosterone level. Computerized tomography demonstrated a left adrenal adenoma, shown on adrenal scintigraphy to be functioning. The elevated basal level of plasma corticosterone and its increased response to 1-24 adrenocorticotropic hormone suggested the tumor produced corticosterone. The surgical specimen was a benign adrenocortical adenoma with excess content of corticosterone and 18-hydroxycorticosterone.
Morioka
M
M
Department of Urology, Kochi Medical School, Japan.
Sen
Y
Y
Inoue
K
K
Fujita
Y
Y
D015069:18-Hydroxycorticosterone / Q000378:metabolism*; D000236:Adenoma / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism*; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000378:metabolism*; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011782:Quadriplegia / Q000209:etiology
D015069:18-Hydroxycorticosterone; D003345:Corticosterone