Successful treatment of systemic blastomycosis with high-dose ketoconazole in a renal transplant recipient.
A case of disseminated blastomycosis in a male renal transplant recipient is presented. Discontinuation of immunosuppressive therapy and treatment with high-dose ketoconazole was successful in treating the patient's cutaneous and pulmonary disease initially. Ketoconazole was discontinued after 12 months of chronic therapy, but 2 weeks after discontinuation, blastomycosis recurred. High-dose ketoconazole was again effective; the patient remains asymptomatic presently on chronic suppressive therapy with ketoconazole.
Hii
J H
JH
Department of Microbiology, Toronto Hospital, Ontario, Canada.
Legault
L
L
DeVeber
G
G
Vas
S I
SI
D000368:Aged; D001759:Blastomycosis / Q000188:drug therapy*; D002908:Chronic Disease; D003881:Dermatomycoses / Q000188:drug therapy; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*
D007654:Ketoconazole