[Sterigmatocystin induced adenocarcinoma of the lung and atypical hyperplasia of glandular stomach in mice].
Aspergillus versicolor was isolated from the gastric juice of patients with chronic stomach diseases in high-risk area of gastric cancer. Mice fed with aspergillus-inoculated corn flour developed adenocarcinoma of the lung in 15 of 35 mice (42.9%) and atypical hyperplasia of the glandular stomach in 13 of 35 mice (37.4%). Sterigmatocystin was identified by HPLC and fluorescence spectrophotometry in the extract of aspergillus-inoculated corn flour. The results suggest that the mycotoxin sterigmatocystin is a potential carcinogen in human.
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Hebei Medical College, Shijiazhuang.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D005260:Female; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011230:Precancerous Conditions / Q000139:chemically induced; D013241:Sterigmatocystin; D013270:Stomach / Q000473:pathology*
D013241:Sterigmatocystin