[Description of a special form of postprandial hyperlipidemia: possible cause of premature coronary heart disease].
We have studied the metabolism of post-prandial lipoproteins in four male patients who suffered from premature (less than 60 years) angiographically proven coronary heart disease. They had normal to low total and low density lipoprotein cholesterol levels. Other risk factors were absent. Using the vitamin A fat loading test we were able to show that the clearance of chylomicron remnants was delayed compared to three healthy control subjects. Since these postprandial lipoproteins have been implicated in atherogenesis, we conclude that this defect contributed to the development of coronary heart disease in these patients.
Wieland
E
E
Abteilung für klinische Chemie der Universität Göttingen.
Walli
A K
AK
Niedmann
P D
PD
Lohstöter
C
C
Kraemer
A
A
Seidel
D
D
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics; D003327:Coronary Disease / Q000209:etiology*; D004435:Eating; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors
D001057:Apolipoproteins E
Beschreibung einer besonderen Form von post-prandialer Hyperlipidämie: mögliche Ursache einer frühzeitigen koronaren Herzkrankheit.