[Membrane mechanisms of the effect of alkylating cytostatic agents].
The data bearing witness to realization of the cytostatic activity of alkylating agents by means of interaction with cell membrane receptors was obtained. Alkylating agents block receptors of the polyphosphoinositol system. It is shown that chloralkylamines inhibiting sites coincide with M-++cholinomimetics and alpha-adrenergic receptors, inhibitors of H-histamine receptors, cyclo- and lypoxigenase inhibitors. Such likeness is determined by identical structures of the molecule active part, and quantum-chemical calculations.
Mukhin
V V
VV
Poda
G I
GI
Luĭk
A I
AI
Baldenkov
G N
GN
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001665:Binding Sites; D002462:Cell Membrane / Q000187:drug effects*; D002540:Cerebral Cortex / Q000648:ultrastructure; D003342:Corpus Striatum / Q000648:ultrastructure; D066298:In Vitro Techniques; D008099:Liver / Q000648:ultrastructure; D008958:Models, Molecular; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits
D000477:Alkylating Agents; D000970:Antineoplastic Agents
Membrannye mekhanizmy deĭstviia alkiliruiushchikh tsitostatikov.