Acute pancreatitis during oral 5-aminosalicylic acid therapy.
Therapy with oral 5-aminosalicylic acid for inflammatory bowel disease has been reported as effective and safe. We report two cases of biochemically proven mild acute pancreatitis occurring 2 and 14 days, respectively, after oral 5-aminosalicylic acid therapy was instituted for inflammatory bowel disease. A hypersensitivity mechanism might be involved, owing to possible erratic systemic absorption of the drug. We suggest clinical and biochemical monitoring for patients undergoing oral 5-aminosalicylic acid therapy in order to confirm its possible association with acute pancreatitis and to assess the actual incidence of such an adverse reaction.
Fiorentini
M T
MT
Divisione di Gastroenterologia, Ospedale Mauriziano Umberto I di Torino, Italy.
Fracchia
M
M
Galatola
G
G
Barlotta
A
A
de la Pierre
M
M
D000208:Acute Disease; D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019804:Mesalamine; D010195:Pancreatitis / Q000139:chemically induced*
D000636:Aminosalicylic Acids; D019804:Mesalamine