Proliferation of marginal zone cells mimicking malignant lymphoma.
An enlarged axillary lymph node from a 58-year-old woman showed a proliferation of marginal zone cells in nodules or large band-forming aggregates within the cortex. The marginal zone cells also infiltrated the adjacent fatty tissue. They showed polytypic surface immunoglobulins (IgM++, IgG+, kappa+, lambda+). Their immunophenotype (IgD-, CD23-, KiB3-) differed from that of the small lymphocytes of the mantle zone. They were also positive for alkaline phosphatase. The lesion is reactive and must be differentiated from low-grade malignant lymphomas, especially centrocytic lymphoma.
van Krieken
J H
JH
Department of Pathology, Leiden University Hospital, The Netherlands.
Lennert
K
K
D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D001365:Axilla / Q000473:pathology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008199:Lymphadenitis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008223:Lymphoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010641:Phenotype
D015703:Antigens, CD