[The relationship between the physicochemical and pharmacokinetic parameters and the anti-arrhythmia activity of bonnecor and its metabolites].
The antioxidant properties of a new antiarrhythmic drug bonnecor and its main metabolites were determined by using chemoluminescence. A significant correlation was revealed between the physicochemical properties, antiarrhythmic activity, pharmacokinetic parameters of bonnecor and its metabolites.
Rodionov
A P
AP
Zolotov
N N
NN
Lyskovtsev
V V
VV
Zalilov
K Iu
KIu
Poppe
H
H
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants; D002415:Cats; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002853:Chromatography, Liquid; D003984:Dibenzazepines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D005609:Free Radicals; D008401:Gas Chromatography-Mass Spectrometry; D008163:Luminescent Measurements
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D003984:Dibenzazepines; D005609:Free Radicals; C048166:tiracizine
Vzaimosviaz' mezhdu nekotorymi fiziko-khimicheskimi, farmakokineticheskimi parametrami i antiaritmicheskoĭ aktivnost'iu bonnekora i ego metabolitov.