Antioxidant enzymatic systems in human erythrocytes from subjects with chronic cerebrovascular disease.
In the present study we have assayed antioxidant enzymatic systems in erythrocytes from subjects with chronic cerebrovascular disease to correlate their involvement in red cell deformability. A significant decrease of glutathione peroxidase, reductase, catalase and superoxide dismutase activities has been found in human red blood cells from patients with chronic cerebrovascular disease when compared to the control group. The decrease in antioxidant enzymatic systems found in these patients was accompanied by reduced cellular resistance to hydrogen peroxide. An altered balance between the partially reduced forms of oxygen metabolism and the antioxidant enzymatic systems could play a crucial role in the haemorheological alteration frequently occurring in subjects affected by chronic cerebrovascular disease.
Vanella
A
A
Chair of Biochemistry, School of Pharmacy, University of Catania, Italy.
Scalia
R
R
Terminella
C
C
Gambera
G
G
Castorina
C
C
Sorrenti
V
V
Campisi
A
A
Bianchi
A
A
D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000201:enzymology*; D002908:Chronic Disease; D004907:Erythrocyte Deformability / Q000502:physiology; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase