Degradation of human cartilage by monocytes.
The effect of human peripheral blood monocytes on the degradation of human articular cartilage was studied in vitro using a radiometric assay to detect proteoglycan breakdown. The results showed that proteoglycan breakdown was increased by 60% after a 20 h exposure to monocytes (p less than 0.001).
Kumaratilake
L M
LM
Department of Immunology, Adelaide Children's Hospital, North Adelaide, South Australia.
Kowanko
I C
IC
Bates
E J
EJ
Ferrante
A
A
D002358:Cartilage, Articular / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism
D011509:Proteoglycans