Mitosis and histopathology in rat liver during methylclofenapate-induced hyperplasia.
Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larger (21.3%) peak in arrested metaphases at 36 h after partial hepatectomy, but was still unexpectedly large in comparison with the S-phase response to methylclofenapate reported in a previous study. Progressive hypertrophic histopathological changes were apparent during the whole course of treatment.
Bybee
A
A
ICI Central Toxicology Laboratory, Macclesfield, Cheshire, U.K.
Styles
J A
JA
Beck
S L
SL
Blackburn
D
D
D000818:Animals; D002087:Butyrates; D056486:Chemical and Drug Induced Liver Injury; D002992:Clofenapate; D003078:Colchicine / Q000494:pharmacology; D006965:Hyperplasia / Q000139:chemically induced*; D008107:Liver Diseases / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index; D051381:Rats; D011919:Rats, Inbred Strains
D002087:Butyrates; D002992:Clofenapate; D003078:Colchicine