title: Paradoxical bone mineralisation in the twin to twin transfusion syndrome.
abstract: We report twin preterm infants with the twin to twin transfusion syndrome, exhibiting grossly different bone densities on chest radiographs. Photonabsorptiometry showed the polycythaemic twin was osteopenic and the anaemic twin osteosclerotic; bone mineral contents were 0.028 g/cm and 0.074 g/cm respectively (normal mean (SD) 0.041 (0.006) g/cm. We speculate that alterations in macrophage derived osteoclastic activity contribute to these previously unreported findings.
authors.affiliation: MRC Dunn Nutrition Unit, Cambridge.
authors.forename: N J
authors.initials: NJ
authors.lastname: Bishop
authors.forename: F J
authors.initials: FJ
authors.lastname: King
authors.forename: P
authors.initials: P
authors.lastname: Ward
authors.forename: J M
authors.initials: JM
authors.lastname: Rennie
authors.forename: A K
authors.initials: AK
authors.lastname: Dixon
mesh_terms: D015502:Absorptiometry, Photon; D000469:Alkaline Phosphatase / Q000097:blood; D000886:Anthropometry; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002113:Calcification, Physiologic / Q000502:physiology; D002118:Calcium / Q000097:blood; D005260:Female; D005330:Fetofetal Transfusion / Q000097:blood / Q000150:complications*; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D010026:Osteosclerosis / Q000209:etiology*; D010710:Phosphates / Q000097:blood; D011247:Pregnancy; D013902:Radiography, Thoracic
chemical_list: D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium