title: Competition between tuftsin and HBV S-protein sequences.
abstract: The syntheses of HBV S-protein partial sequences: Thr-Lys-Pro-Thr (I), Thr-Lys-Pro-Thr-Asp (II), and Thr-Lys-Pro-Thr-Asp-Gly (III) and also of pentapeptide Thr-Lys-Pro-Gly-Arg (IV), are described. For the peptides II and III inhibitory activity against tuftsin was found. Peptide IV (an analogue of tuftsin-inhibitor Thr-Lys-Pro-Pro-Arg) demonstrated a tuftsin-like activity in the phagocytosis experiments.
authors.affiliation: Institute of Chemistry, Wrocław University, Poland.
authors.forename: I Z
authors.initials: IZ
authors.lastname: Siemion
authors.forename: J
authors.initials: J
authors.lastname: Słoń
authors.forename: E
authors.initials: E
authors.lastname: Nawrocka
authors.forename: Z
authors.initials: Z
authors.lastname: Wieczorek
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens; D066298:In Vitro Techniques; D007962:Leukocytes / Q000502:physiology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D014405:Tuftsin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D006514:Hepatitis B Surface Antigens; D010446:Peptide Fragments; D014405:Tuftsin