title: Sensorineural hearing loss associated with Kawasaki disease.
abstract: In five children who met the diagnostic criteria for Kawasaki Disease, sensorineural hearing loss developed in association with the acute illness. The children, aged 7 months to 13 years, had deficits ranging from mild to profound bilateral sensorineural hearing loss. There were no associated neurologic abnormalities, and immunologic investigations and magnetic resonance imaging failed to reveal a cause. Treatment regimens differed among the children, but none had high salicylate levels (greater than 20 mg/dl) or received other ototoxic medications. Antiinflammatory therapy was not obviously beneficial in any case, and four of the children have persistent hearing deficits. We conclude that auditory involvement may be a complication of Kawasaki disease; screening of clinically affected children should be considered.
authors.affiliation: Department of Medicine, Children's Hospital, Boston, Massachusetts.
authors.forename: R P
authors.initials: RP
authors.lastname: Sundel
authors.forename: J W
authors.initials: JW
authors.lastname: Newburger
authors.forename: T
authors.initials: T
authors.lastname: McGill
authors.forename: S S
authors.initials: SS
authors.lastname: Cleveland
authors.forename: W W
authors.initials: WW
authors.lastname: Miller
authors.forename: B
authors.initials: B
authors.lastname: Berry
authors.forename: A M
authors.initials: AM
authors.lastname: Klein
authors.forename: J C
authors.initials: JC
authors.lastname: Burns
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006320:Hearing Tests; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents