Pharmacokinetics and tissue penetration of cefprozil.
The pharmacokinetics of cefprozil after a single 500 mg oral dose were studied, measuring plasma, inflammatory fluid and urine concentrations. Mean peak plasma concentrations of 9.6 mg/l (measured by bioassay) were achieved at a mean time of 1.9 h after administration. The mean plasma elimination half-life was 1.4 h; 63.6% of the dose was eliminated in urine by 24 h. Mean peak levels in inflammatory fluid reached 4.9 mg/l after 3.5 h. Mean plasma levels remained 2 mg/l for almost 5 h post dose and more than 6 h in inflammatory fluid. These data suggest that infections caused by highly susceptible pathogens might respond to a twice daily dosing regimen and less susceptible pathogens might require a higher dose or more frequent administration.
Nye
K
K
Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
O'Neill
P
P
Andrews
J M
JM
Wise
R
R
D000328:Adult; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008297:Male; D014018:Tissue Distribution; D000097670:Cefprozil
D002511:Cephalosporins; D000097670:Cefprozil