Modification of prostaglandin metabolism in vivo by long-chain omega-3 polyunsaturates.
In a pilot study conducted with a healthy male volunteer we determined that short-term dietary supplementation with fish oil markedly suppresses the systemic production of prostaglandin E (P = 0.04). This biochemical effect is observable after an incubation period of several days. The potential consequences of a reduced PGE synthetic rate on renal function, immune system and vascular dynamics, must be considered in the overall evaluation of the safety of fish oil supplements.
Ferretti
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A
Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, USDA, MD 20705.
Flanagan
V P
VP
D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005395:Fish Oils / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D011453:Prostaglandins; D011458:Prostaglandins E; C060580:Promega