Concentration of ofloxacin and ciprofloxacin in human semen following a single oral dose.
A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.
Berger
S A
SA
Department of Microbiology, Tel-Aviv Medical Center, Israel.
Yavetz
H
H
Paz
G
G
Gorea
A
A
Homonnai
Z
Z
D000284:Administration, Oral; D000328:Adult; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D012661:Semen / Q000032:analysis*; D013997:Time Factors
D002939:Ciprofloxacin; D015242:Ofloxacin