Human T-cell leukemia virus type I trans activator induces class I major histocompatibility complex antigen expression in glial cells.
Transfection of the tax gene encoding the trans activator of human T-cell leukemia virus type I into glial line cells induced class I major histocompatibility complex (MHC) antigens on these cells. This occurred through the interaction of tax protein with the gene encoding class I MHC antigens but not through any soluble factors, such as interferons, or factors from glial cells. Since neural cells do not usually express MHC antigens, this novel mechanism may be an intermediate event between viral infection and subsequent immune-mediated pathology in the central nervous system.
Sawada
M
M
Division of Cell Biology, Fujita Health University, Aichi, Japan.
Suzumura
A
A
Yoshida
M
M
Marunouchi
T
T
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D005434:Flow Cytometry; D015870:Gene Expression; D005805:Genes, MHC Class I; D005814:Genes, Viral; D006183:H-2 Antigens / Q000235:genetics*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D009457:Neuroglia / Q000276:immunology; D051381:Rats; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology*; D014162:Transfection
D006183:H-2 Antigens; D015534:Trans-Activators