title: Orange/black discolouration of the bowel (at laparotomy) due to clofazimine.
abstract: Clofazimine, a commonly used anti-lepromatous drug, is now being prescribed for the treatment of pyoderma gangrenosum, a complication of inflammatory bowel disease. This drug can cause an obstructive exacerbation of Crohn's disease. Surgeons should be aware of the orange/black discolouration of the bowel, which may mimic ischaemia macroscopically. A case, the first reported in Australia, is described and the literature discussed.
authors.affiliation: Department of Gastroenterology, Prince Henry's Hospital, Melbourne, Victoria, Australia.
authors.forename: M N
authors.initials: MN
authors.lastname: Merrett
authors.forename: R W
authors.initials: RW
authors.lastname: King
authors.forename: K E
authors.initials: KE
authors.lastname: Farrell
authors.forename: H
authors.initials: H
authors.lastname: Zeimer
authors.forename: E
authors.initials: E
authors.lastname: Guli
mesh_terms: D000328:Adult; D002991:Clofazimine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D011711:Pyoderma / Q000188:drug therapy*
chemical_list: D002991:Clofazimine