Tumorigenicity of nickel subsulfide in Strain A/J mice.
The pulmonary tumor response of Strain A mice has been reported to be a rapid and efficient predictor of carcinogenic potential for a variety of chemicals. The route of exposure has usually been by intraperitoneal injection (i.p.) of solubilized materials. We compared intratracheal (i.t.) instillation as a more representative route typical of human exposures, with i.p. injection of nickel subsulfide, a potent animal carcinogen. Animals were sacrificed either 20 weeks after the first dosing, or were held until 45 weeks after the first dosing. Urethane, a positive control, produced a significant increase in pulmonary tumor response after i.t. instillation as well as i.p. injection. For nickel subsulfide treated animals, there was no evidence of a dose-related increase in pulmonary tumor response in any i.p. or i.t. treatment group when compared with age-matched controls.
McNeill
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Battelle, Columbus, Ohio 43201.
Chrisp
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Fisher
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D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000280:Administration, Inhalation; D000818:Animals; D002273:Carcinogens; D007274:Injections, Intraperitoneal; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009532:Nickel / Q000633:toxicity*; D010316:Particle Size; D014520:Urethane / Q000633:toxicity
D002273:Carcinogens; D014520:Urethane; D009532:Nickel; C017557:nickel subsulfide