Impaired active avoidance responding in rats selectively bred for increased cholinergic function.
It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.
Overstreet
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DH
Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill 27514.
Rezvani
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AH
Janowsky
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DS
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology; D002799:Cholinergic Fibers / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000235:genetics*; D012641:Selection, Genetic; D013045:Species Specificity
D011950:Receptors, Cholinergic