title: Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma.
abstract: The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.
authors.affiliation: II Clinica Otorinolaringoiatrica, Università degli Studi di Torino, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Bongioannini
authors.forename: M
authors.initials: M
authors.lastname: Vercellino
authors.forename: M G
authors.initials: MG
authors.lastname: Rugiu
authors.forename: A
authors.initials: A
authors.lastname: Ferreri
authors.forename: G
authors.initials: G
authors.lastname: Succo
authors.forename: G
authors.initials: G
authors.lastname: Cortesina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007108:Immune Tolerance; D007432:Intraoperative Period; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D011184:Postoperative Period; D065227:Transfusion Reaction