title: Synthetic fragments and analogues of elastin. I. The synthesis.
abstract: The synthesis of some repetitive sequences of elastin and their simplified analogues, all comprising the structural unit Gly-X-Gly (X = Val, Leu, Ala), is described. In particular, the following peptides and polypeptides were synthesized and characterized: Boc-Gly-Val-Gly-Gly-Leu-OMe, Boc-Gly-Leu-Gly-Gly-Val-OMe, Boc-(Gly-Val-Gly-Gly-Leu)2-OMe, Boc-(Gly-Val-Gly-Gly-Leu)3-OMe, Boc-Gly-Val-Gly-Gly-OEt, Boc-Leu-Gly-Gly-Leu-OMe, Boc-Val-Gly-Gly-Val-OMe, poly(Ala-Gly-Gly), poly(Val-Gly-Gly), and poly(Leu-Gly-Gly). In every case, the synthesis was accomplished by classical procedures in solution, by using the p-nitrophenyl ester method for the polycondensation step, and the mixed anhydride or the azide methods for the coupling steps.
authors.affiliation: Department of Inorganic, Metallorganic and Analytical Chemistry, University of Padova, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Guantieri
authors.forename: S
authors.initials: S
authors.lastname: Grando
authors.forename: L
authors.initials: L
authors.lastname: Pandolfo
authors.forename: A M
authors.initials: AM
authors.lastname: Tamburro
mesh_terms: D000595:Amino Acid Sequence; D004549:Elastin / Q000031:analogs & derivatives*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis*
chemical_list: D010446:Peptide Fragments; D004549:Elastin