title: Fever, haemoglobin and smoking as prognostic factors during the treatment of cervical carcinoma by radiotherapy.
abstract: In a series of 151 patients diagnosed with cervical carcinoma the prognostic importance of temperature elevation, anaemia and smoking during radiotherapy was evaluated. Tumor necrosis and infection at the start of therapy were also analysed. A febrile reaction during irradiation seems to be an ominous sign with regard to tumour cure and survival rates. It was not possible to verify any enhancement of the radiotherapeutic effect by hyperthermia in the 38-40 degrees C body temperature range. A haemoglobin level less than 120 g/l and tumour necrosis were highly significantly associated with local treatment failure, tumour recurrences and decreased patient survival. Smoking during radiotherapy was a non-significant prognostic variable when tested by a multivariate technique.
authors.affiliation: Department of Gynaecological Oncology, Orebro Medical Centre Hospital, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Solberger
authors.forename: B
authors.initials: B
authors.lastname: Sorbe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D002277:Carcinoma / Q000532:radiotherapy*; D005260:Female; D005334:Fever / Q000150:complications*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012907:Smoking; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
chemical_list: D006454:Hemoglobins; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase