[Relationship of oral leukoplakia and cancer by immunohistochemical expression of EGF-receptor].
To examine the relationship between the oral leukoplakia and cancer, an immunohistochemical study of the EGF-receptor was performed by the avidin-biotin peroxidase-complex method and silver enhancement with anti-human EGF-receptor antibody (Bio-yeda). Totally 61 cases of leukoplakias without relation to cancer, 20 cases of leukoplakias with relation to cancer and 31 cases of squamous cell carcinomas were examined. Seventy percent of leukoplakias and 55% of cancer cases were positive for the EGF-receptor. The proportion of the EGF-receptor-positive cells in the leukoplakia cases was slightly decreased in proportion to the degree of the epithelial dysplasia. The proportion of the EGF-receptor-positive cells in the poorly differentiated type cancer cases (3%) was fewer than that in the differentiated type cancer cases (31%). In the leukoplakia related to cancer, the leukoplakia and cancer of the same patient did not always show the same pattern of EGF-receptor.
Yamada
T
T
Department of Oral Pathology, Faculty of Dentistry, Tokyo Medical and Dental University.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology
D066246:ErbB Receptors