title: The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells.
abstract: In an investigation of the action of integerrimine on chromosomes, the bone marrow was taken as target organ. Male and female mice of the C57Bl/6 strain received a single acute dose of this pyrrolizidine alkaloid, in 2 concentrations: 18.75 and 37.50 mg/kg. Bone marrow cells were collected 6, 12 and 24 h after treatment. The analysis of metaphasic chromosomes demonstrated that chromosomal damage occurs, correlated with drug concentration. The greatest frequency of chromosomal aberrations was detected 12 h after treatment.
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Gimmler-Luz
authors.forename: B
authors.initials: B
authors.lastname: Erdtmann
authors.forename: R A
authors.initials: RA
authors.lastname: Balbueno
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*
chemical_list: D011763:Pyrrolizidine Alkaloids; C009237:senecionine