title: Cerebral perfusion changes in schizophrenic patients using Tc-99m hexamethylpropylene amineoxime (HMPAO).
abstract: Tc-99m hexamethylpropylene amineoxime (HMPAO) was used to image cerebral perfusion changes in 20 patients with chronic schizophrenia (19 male and 1 female, aged 22-48, at an average age of 29.0). All were being given neuroleptic drugs. Twelve had electroconvulsive therapy. In addition, all had abnormal studies except one, who was normal and had a poor response to treatment. Ventricular dilatation and cerebral atrophy was seen in eleven patients, and 77 focal lesions were detected. Forty-two lesions demonstrated increased HMPAO retention, which was distributed as follows: 26 in the basal ganglia in 14 patients (12 bilateral, 2 unilateral); 10 along the sylvian fissure in the parietotemporal region; and 3 in the frontal and 1 in each of the temporal, parietal, and occipital regions. Thirty-five focal lesions exhibited decreased perfusion: ten parietal, eight frontal, seven temporal, six cerebellar, and four occipital lobes. This study demonstrates the potential value of Tc-99m HMPAO in schizophrenia and other psychiatric disorders.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat.
authors.forename: H M
authors.initials: HM
authors.lastname: Abdel-Dayem
authors.forename: S
authors.initials: S
authors.lastname: el-Hilu
authors.forename: A
authors.initials: A
authors.lastname: Sehweil
authors.forename: E
authors.initials: E
authors.lastname: Higazi
authors.forename: S
authors.initials: S
authors.lastname: Jahan
authors.forename: M
authors.initials: M
authors.lastname: Salhat
authors.forename: S
authors.initials: S
authors.lastname: al-Mohannadi
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime