Neuroleptic malignant syndrome and hypothyroidism.
Two patients with primary hypothyroidism who developed neuroleptic malignant syndrome (NMS) are described. Thyroid disease might predispose to NMS by altering brain dopamine metabolism.
Moore
A P
AP
Department of Neurological Science, University of Liverpool, Walton Hospital, Liverpool, United Kingdom.
Macfarlane
I A
IA
Blumhardt
L D
LD
D000328:Adult; D001921:Brain / Q000187:drug effects; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D010259:Paranoid Disorders / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000187:drug effects; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects*; D013974:Thyroxine / Q000097:blood
D011954:Receptors, Dopamine; D013881:Thioridazine; D013974:Thyroxine