title: Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy.
abstract: Ochratoxin A (OA), a mycotoxin which induces nephropathy and kidney tumours in rats and mice, is a contaminant of food consumed by a population with a high incidence of endemic nephropathy (EN). It was therefore tested in vitro for its ability to induce chromosomal aberrations in human peripheral lymphocytes in a small number of subjects, in the presence or absence of a kidney microsomal metabolic activation system. OA was found to induce aberrations on X chromosomes of similar types to those previously detected in lymphocytes from patients suffering from endemic nephropathy.
authors.affiliation: National Oncological Center, Bulgarian Medical Academy, Sofia.
authors.forename: Y
authors.initials: Y
authors.lastname: Manolova
authors.forename: G
authors.initials: G
authors.lastname: Manolov
authors.forename: L
authors.initials: L
authors.lastname: Parvanova
authors.forename: T
authors.initials: T
authors.lastname: Petkova-Bocharova
authors.forename: M
authors.initials: M
authors.lastname: Castegnaro
authors.forename: I N
authors.initials: IN
authors.lastname: Chernozemsky
mesh_terms: D000818:Animals; D001449:Balkan Nephropathy / Q000209:etiology / Q000235:genetics; D001711:Biotransformation; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D007668:Kidney / Q000378:metabolism; D008214:Lymphocytes; D008861:Microsomes / Q000378:metabolism; D009793:Ochratoxins / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D014314:Trisomy; D014960:X Chromosome
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A