title: [Changes in surface activity of surfactant and ultrastructure of the air-blood barrier in alcoholic intoxication in experimental animals].
abstract: In the results of complex investigation of the lungs of 26 white rats, it was established, that there is the suppression of surface active properties of surfactant under influence of ethanol. In acute poisoning this suppression is associated with direct injury of surfactant with ethanol and inactivation of surfactant with serum proteins, which appear in the alveolar space because of the edema of air-haematic barrier. In prolonged influence the suppression of the surface activity of surfactant is due to the increase of its catabolism with alveolar macrophages.
authors.forename: A K
authors.initials: AK
authors.lastname: Zagorul'ko
authors.forename: A A
authors.initials: AA
authors.lastname: Birkun
authors.forename: E E
authors.initials: EE
authors.lastname: Fisik
authors.forename: L G
authors.initials: LG
authors.lastname: Safronova
mesh_terms: D000435:Alcoholic Intoxication / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D015824:Blood-Air Barrier / Q000187:drug effects* / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D008168:Lung / Q000648:ultrastructure*; D008264:Macrophages / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000648:ultrastructure; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013501:Surface-Active Agents / Q000032:analysis*
chemical_list: D013501:Surface-Active Agents; D000431:Ethanol
vernacular_title: Izmeneniia poverkhnostnoĭ aktivnosti surfaktanta i ul'trastruktura aérogematicheskogo bar'era pri alkogol'noĭ intoksikatsii v éksperimente.