Fc receptor gene translocation in a t(1;19) pre-B ALL cell line.
We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene.
Webber
L M
LM
Department of Cytogenetics and Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
Garson
O M
OM
Tate
B
B
McKenzie
I F
IF
Hogarth
P M
PM
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D009693:Nucleic Acid Hybridization; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011961:Receptors, Fc / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D011961:Receptors, Fc