title: Inhibition of mitochondrial palmitate oxidation by calmodulin antagonists.
abstract: 1. The effect of calmodulin antagonists on the rate of palmitate oxidation by isolated rat liver mitochondria was studied. 2. In the presence of 100 microM amitriptyline, chlorpromazine, prenylamine, N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide or N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, palmitate oxidation was inhibited by 17, 34, 49, 31 and 37%, respectively. 3. The degree of inhibition of palmitate oxidation exerted by these chemical compounds did not appear to correlate appreciably with changes in mitochondrial membrane fluidity.
authors.affiliation: Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, MD 20705.
authors.forename: G
authors.initials: G
authors.lastname: Loo
authors.forename: E
authors.initials: E
authors.lastname: Berlin
authors.forename: J T
authors.initials: JT
authors.lastname: Smith
mesh_terms: D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010168:Palmitates / Q000378:metabolism*; D010169:Palmitic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002147:Calmodulin; D010168:Palmitates; D010169:Palmitic Acids