Type I protein S deficiency and skin necrosis.
A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.
Craig
A
A
Department of Haematology, Withington Hospital, Manchester, UK.
Taberner
D A
DA
Fisher
A H
AH
Foster
D N
DN
Mitra
J
J
D000074:Acenocoumarol / Q000009:adverse effects; D000328:Adult; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008297:Male; D009336:Necrosis; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011486:Protein C / Q000302:isolation & purification; D012867:Skin / Q000473:pathology*; D013924:Thrombophlebitis / Q000188:drug therapy*; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors
D011486:Protein C; D014157:Transcription Factors; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors; C018648:transcription factor S-II; D006493:Heparin; D000074:Acenocoumarol