[Sex hormone metabolism in acute systemic lupus erythematosus].
The numerous clinical and experimental data suggesting a lupus-induced modulation of sex hormones prompted the study of sex hormone metabolism in these patients. Some hormonal abnormalities were reported in female patients: a) over production of 16-alpha-hydroxylated estradiol derivatives with potent peripheral estrogenic activities; b) under production of the following androgens: testosterone, dihydrotestosterone, dihydroandrosterone, dihydroandrosterone sulfate, delta 4-androstenedione. Moreover, some observations suggest an excessive transformation of androgens into estrogens: increased oxidation of testosterone on C17, skin lesions, abnormal skin, aromatase activity responsible for estradiol synthesis.
Dougados
M
M
Clinique de Rhumatologie, Hôpital Cochin, Paris.
D000208:Acute Disease; D000728:Androgens / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004967:Estrogens / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000728:Androgens; D004967:Estrogens
Métabolisme des hormones sexuelles au cours du lupus érythémateux aigu disséminé.