title: CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.
abstract: A new polyether antibiotic CP-84,657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Treponema hyodysenteriae.
authors.affiliation: Central Research, Pfizer Inc., Groton, CT 06340.
authors.forename: J P
authors.initials: JP
authors.lastname: Dirlam
authors.forename: A M
authors.initials: AM
authors.lastname: Belton
authors.forename: J
authors.initials: J
authors.lastname: Bordner
authors.forename: W P
authors.initials: WP
authors.lastname: Cullen
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: J R
authors.initials: JR
authors.lastname: Oscarson
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D003461:Crystallography; D004539:Eimeria / Q000187:drug effects*; D005285:Fermentation; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011714:Pyrans / Q000494:pharmacology; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D005663:Furans; D011714:Pyrans; C065219:CP 84657; C010327:salinomycin; D000095662:Polyether Polyketides