Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1.
A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.
Whitman
G J
GJ
Department of Surgery, University of Colorado, Denver.
Martel
D
D
Weiss
M
M
Pochanapring
A
A
See
W M
WM
Hopeman
A
A
Harken
A H
AH
Dauber
I M
IM
D000527:Alprostadil / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000009:adverse effects* / Q000627:therapeutic use; D014652:Vascular Diseases / Q000139:chemically induced* / Q000188:drug therapy; D014661:Vasoconstriction / Q000187:drug effects
D011479:Protamines; D000527:Alprostadil