[A high pressure liquid chromatography method for detecting the isoniazid derivative isonicotinoyl-hydrazine sodium glucuronide, free isoniazid and acetylisoniazid and its use in pharmacologic studies].
A specific direct method for determining the isoniazid derivative isonicotinoyl-hydrazine sodium glucuronide (INHG-Na) with the aid of high-pressure liquid chromatography has been developed, which permits the analysis of this derivative of isoniazid in addition to isoniazid itself and acetylisoniazid in the plasma of patients. In initial pharmacokinetic applications of the method, it has been shown that plasma INHG-Na is a stable substance that liberates only negligible concentrations of INH.
Musch
E
E
Medizinische Universitätsklinik Bonn.
Lütjohann
D
D
Peter
M G
MG
Schwabe
H K
HK
D000107:Acetylation; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D010641:Phenotype; D014397:Tuberculosis, Pulmonary / Q000097:blood*
C006377:(N)1-acetylisoniazid; C064889:isonicotinoylhydrazine glucuronide; D007538:Isoniazid
Hochdruckflüssigchromatographische Nachweismethode für das Isoniazidderivat Isonicotinoyl-Hydrazinnatriumglucuronid neben freiem Isoniazid und Azetylisoniazid und ihre Anwendung für pharmakologische Untersuchungen.