[Interaction between phenobarbital and ciclosporin following renal transplantation: a case report].
We report a case of decreased ciclosporin (CsA) trough level due to the interaction with phenobarbital after living renal transplantation in a 15-year-old male. Two other cases prescribed valproate sodium as an anticonvulsant, showed no change in the plasma CsA levels. Therefore, it is necessary to recognize the drug interaction with CsA, and appropriate drug should be chosen in clinical renal transplantation.
Nishioka
T
T
Department of Urology, Kinki University School of Medicine.
Ikegami
M
M
Imanishi
M
M
Ishii
T
T
Uemura
T
T
Kunikata
S
S
Kanda
H
H
Matsuura
T
T
Akiyama
T
T
Kurita
T
T
D000293:Adolescent; D003524:Cyclosporins / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*
D003524:Cyclosporins; D010634:Phenobarbital