title: Detection of somatotropin receptors on human monocytes.
abstract: The expression of somatotropin receptors on human peripheral blood monocytes was investigated. Binding of [125I]somatotropin to human monocytes was found to be specific and saturable. The binding was rapid and time-dependent, and was abolished by pretreatment of monocytes with trypsin. Scatchard plot analysis revealed that each cell bore more than 8 x 10(3) binding sites with an affinity constant of 1 x 10(8) M-1.
authors.affiliation: Immunobiological Laboratories, Inc., New York, NY.
authors.forename: P
authors.initials: P
authors.lastname: Jafari
authors.forename: D N
authors.initials: DN
authors.lastname: Khansari
mesh_terms: D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000032:analysis*; D011485:Protein Binding; D011986:Receptors, Somatotropin / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D014357:Trypsin / Q000494:pharmacology
chemical_list: D011986:Receptors, Somatotropin; D013006:Growth Hormone; D014357:Trypsin