title: Association of L-tryptophan and an illness resembling eosinophilic fasciitis. Clinical and histopathologic findings in four patients with eosinophilia-myalgia syndrome.
abstract: The Centers for Disease Control has recently reported an association between the use of oral L-tryptophan preparations and a disease marked by severe myalgia, peripheral eosinophilia, and neuromuscular and cutaneous abnormalities. They have labeled the condition eosinophilia-myalgia syndrome. We report here the clinical and histopathologic findings in 4 patients who developed an illness resembling eosinophilic fasciitis following the initiation of oral L-tryptophan supplementation.
authors.affiliation: Department of Medicine, University of California, Los Angeles School of Medicine.
authors.forename: K J
authors.initials: KJ
authors.lastname: Bulpitt
authors.forename: M A
authors.initials: MA
authors.lastname: Verity
authors.forename: P J
authors.initials: PJ
authors.lastname: Clements
authors.forename: H E
authors.initials: HE
authors.lastname: Paulus
mesh_terms: D000328:Adult; D001706:Biopsy; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D005208:Fasciitis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000473:pathology; D013577:Syndrome; D014364:Tryptophan / Q000009:adverse effects*
chemical_list: D014364:Tryptophan