[Effects of sexual difference on the toxicity of ethylene oxide. III. The rat hepatic monooxygenase system].
Wistar male and female rats were exposed to ethylene oxide (EO) at a concentration of 250 ppm, 6 hours a day, 5 days a week for 17 weeks and the effect of EO on the hepatic monooxygenase system in regards to the sex difference was investigated. Serum GOT of the exposed male rat slightly increased, but that of the female did not change. Contents of microsomal protein and cytochrome P-450 of the male exposed group decreased significantly compared to the male control group, but that of the female exposed group did not change. The change of cytochrome b5, protoheme and NADH-ferricyanide reductase activity of the female exposed group was the same as that of the male. Although NADPH-cytochrome c reductase activity of the male exposed group did not change, that of the female group exposed increased significantly when compared to the female control group. From these observations, we concluded that the effect of EO on the hepatic monooxygenase system was different between male and female.
Fujishiro
K
K
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mori
K
K
Inoue
N
N
Imazu
K
K
Tanaka
I
I
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005027:Ethylene Oxide / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D009245:NADH Dehydrogenase; D001219:Aspartate Aminotransferases; D005027:Ethylene Oxide