Evidence for a modulation of the stress response by the pineal gland.
Wistar rats show a circadian variation in their response to stress. Pinealectomy exacerbates stress-induced gastric ulceration in rats. This effect is counteracted by melatonin administration.
Khan
R
R
School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
Daya
S
S
Potgieter
B
B
D000818:Animals; D002940:Circadian Rhythm; D003080:Cold Temperature; D005260:Female; D008550:Melatonin / Q000494:pharmacology; D010437:Peptic Ulcer / Q000503:physiopathology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*
D008550:Melatonin