[Antiaggregation action of chloroquine].
The authors have studied in vitro the platelet aggregability induced with ADP, collagen and ristocetin. Chloroquine was added at increasing concentration (3,2 mgr/l, 16 mgr/l, 32 mgr/l). The results have been highly significant. They showed that chloroquine has an anti aggregating effect with the three inducing agents. This effect was increasing with the chloroquine concentration. Some previous works have been indicative of the inhibiting effect of chloroquine on platelet aggregability. In the treatment of the malaria, this inhibiting effect could be complementary with the specific antiparasitic effect. On the other hand the inhibiting effect on platelet aggregability could be useful for the prevention of thrombosis.
Bertrand
E
E
Service de Cardiologie Médicale, Institut de Cardiologie d'Abidjan.
Cloitre
B
B
Ticolat
R
R
Bile
R K
RK
Gautier
C
C
Abiyou
G O
GO
Bohui
B Y
BY
D000328:Adult; D001792:Blood Platelets / Q000032:analysis / Q000187:drug effects / Q000502:physiology; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010740:Phospholipases / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors
D010975:Platelet Aggregation Inhibitors; D002738:Chloroquine; D010740:Phospholipases
Action antiagrégante de la chloroquine.