Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone (CRH)-like immunoreactivity in the rat.
The present study was designed to determine the effects of partial cholinergic denervation on parietal cortical corticotropin-releasing hormone-like immunoreactivity (CRH-LI) in the rat at different ages. Young adult rats received either unilateral or bilateral ibotenic acid infusions into their nucleus basalis, destroying most of the acetylcholinesterase-positive neurons in that region. Parietal cortical levels of CRH-LI were assayed 2.5, 10, 14 and 19 months after placement of nucleus basalis lesions. Parietal CRH-LI was elevated at 10, 14 and 19 months in bilaterally lesioned animals, while unilateral lesions had no effect on CRH-LI.
Millard
W J
WJ
Department of Pharmacodynamics, University of Florida, Gainesville 32610.
Arendash
G W
GW
Dunn
A J
AJ
Meyer
E M
EM
D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001479:Basal Ganglia / Q000254:growth & development / Q000502:physiology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007051:Ibotenic Acid; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D007051:Ibotenic Acid; D003346:Corticotropin-Releasing Hormone