[Comprehensive observation of a canine model of respiratory distress syndrome induced with bone marrow].
An animal model of respiratory distress syndrome (RDS) was made with homologous bone marrow extraction in dogs, which had a similar alter to clinic ARDS patients in blood gases, chest X-ray films and pulmonary pathologic findings. Its pathogenetic key point was extensive pulmonary fat emboli, while active oxygen and neutrophil elastase also play an important role in it. Our results indicate that this model is a rather better one, and anisodamine has some therapeutic effects on the experimental RDS model.
Chen
Z T
ZT
Second Affiliated Hospital, Third Millitary Medical University, PLA. Chongqing.
D000818:Animals; D001853:Bone Marrow; D004285:Dogs; D008054:Lipid Peroxides / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology; D012991:Solanaceous Alkaloids / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D008054:Lipid Peroxides; D012991:Solanaceous Alkaloids; D000515:alpha 1-Antitrypsin; C003922:anisodamine; D013482:Superoxide Dismutase; D010196:Pancreatic Elastase