title: Carcinoma of the prostate. Guidelines for treatment: the role of antiandrogens.
abstract: Our preliminary experience shows that flutamide is effective in patients with stage C or D prostate cancer. Local and distant response rates are comparable to those obtained with "classic" hormone therapy. Libido and sexual potency generally are unaffected. Palliation of symptoms, which is frequent, is usually accompanied by improved performance status and quality of life. Side effects are slight or moderate, but elevated transaminase levels in patients with borderline liver insufficiency are possible.
authors.affiliation: Institute of Urology, University of Palermo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pavone-Macaluso
authors.forename: M
authors.initials: M
authors.lastname: Cacciatore
authors.forename: G
authors.initials: G
authors.lastname: Daricello
authors.forename: C
authors.initials: C
authors.lastname: Pavone
authors.forename: V
authors.initials: V
authors.lastname: Serretta
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D005485:Flutamide / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D048289:Imidazolidines; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000726:Androgen Antagonists; D007093:Imidazoles; D048289:Imidazolidines; C021277:nilutamide; D005485:Flutamide