Correlation of blood pressure in end-stage renal disease with platelet cytosolic free-calcium concentration.
The fluorescent probe Quin-2 showed the cytosolic free-calcium concentration in platelets to be elevated in 12 hypertensive hemodialysis patients, who were compared with 12 normotensive hemodialysis patients. There was a close correlation between the free-calcium level of platelets and mean arterial pressure (r = 0.88). Short-term antihypertensive treatment resulted in a reduction of free-calcium concentration and a concomitant fall in blood pressure. These results suggest an integrative contributory role for calcium in the pathophysiology of hypertension accompanying end-stage renal disease.
Schiffl
H
H
Medizinische Klinik Innenstadt, Universität München.
D000328:Adult; D001262:Atenolol / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood* / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use; D006435:Renal Dialysis
D001262:Atenolol; D009568:Nitrendipine; D002118:Calcium