title: Trehalase inhibitors, validoxylamine A and related compounds as insecticides.
abstract: Validoxylamine A showed a potent inhibitory activity against insect trehalase in a competitive manner with a Ki value of 4.3 x 10(-10) M. The other validoxylamines and validamycins also exhibited the activity in vitro. Injection of these compounds to young last instar larvae of the tobacco cutworm, Spodoptera litura, elicited the morphological abnormality followed by death after the cessation of feeding. Validoxylamine A showed 100% mortality at a dose of 10 micrograms/ last instar larva.
authors.affiliation: School of Pharmacy, Hokuriku University, Kanazawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Asano
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kameda
authors.forename: K
authors.initials: K
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Kono
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology*; D007915:Lepidoptera / Q000201:enzymology*; D009036:Moths / Q000201:enzymology*; D014198:Trehalase / Q000037:antagonists & inhibitors*
chemical_list: D000935:Antifungal Agents; D007306:Insecticides; C050693:validoxylamine G; C052534:validoxylamine A; C052533:validoxylamine B; D007294:Inositol; C003749:validamycins; D014198:Trehalase