Pharmacokinetics of sulfadimidine and its N4-acetyl metabolite in healthy and diseased rabbits infected with Pasteurella multocida.
The pharmacokinetics of sulfadimidine (SDM) and its N4-acetyl metabolite (N4SDM) were investigated after intravenous bolus injection of a single dose (200 mg/kg) of SDM in normal and diseased New Zealand white rabbits. The apparent distribution volume at steady state, total body clearance and elimination half-life of SDM in normal animals were 0.7 +/- 0.3 l/kg, 0.57 +/- 0.24 l/kg/h and 1.6 +/- 1.3 h, respectively. Of the administered dose, 62.1% was metabolized by N4-acetylation, and 12.7 +/- 1.1 and 2.8 +/- 1.8% of the dose was excreted as free drug by the kidney and gastrointestinal tract, respectively. The 'apparent' formation and elimination half-lives of N4SDM were 0.6 +/- 0.4 and 2.2 +/- 1.1 h, respectively. The metabolite was eliminated mainly by excretion through the kidney. There was no significant effect of acute pasteurellosis on the pharmacokinetics of either SDM or N4SDM in rabbits.
Yuan
Z H
ZH
Department of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Fung
K F
KF
D000042:Absorption; D000818:Animals; D005243:Feces / Q000032:analysis; D005260:Female; D008297:Male; D010326:Pasteurella Infections / Q000378:metabolism / Q000662:veterinary*; D011817:Rabbits / Q000378:metabolism*; D013418:Sulfamethazine / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D014018:Tissue Distribution
D013418:Sulfamethazine