title: Cell renewal and ground substance formation in replanted cat teeth.
abstract: The cellular dynamic pattern of pulpal healing 4, 10, 30, and 60 days after replantation of 47 apicoectomized cat incisors was studied after pulse labeling with 3H-thymidine and 35S-sulfate, autoradiography, and routine histology. In the control teeth the labeling index was less than 0.05%. The apical pulpal cells were capable of ground substance formation and cell proliferation already 4 days after replantation, with a labeling index of 7%, which increased up to 43% within 10 days. A gradual postoperative restitution and reorganization within the pulpal cellular compartment was seen. The maximum cell density, reached after 30 days, was reduced to on average 60% compared with the controls. The tissue reorganization was near completion within all pulpal zones after 60 days, and the labeling index was reduced to 2.5%. In some instances internal resorption in cervical pulpal areas negatively influenced the favorable healing. The present study shows that the pulpal healing in replanted teeth follows a consistent basic pattern in cellular dynamics and in histologic changes. The replanted tooth thus seems to be a suitable model for studies of healing and repair in connective tissues.
authors.affiliation: Department of Cariology and Endodontics, School of Dentistry, University of Bergen, Norway.
authors.forename: I
authors.initials: I
authors.lastname: Kvinnsland
authors.forename: K J
authors.initials: KJ
authors.lastname: Heyeraas
mesh_terms: D000818:Animals; D001047:Apicoectomy; D001345:Autoradiography; D002415:Cats; D002452:Cell Count; D002455:Cell Division; D003238:Connective Tissue / Q000502:physiology; D003239:Connective Tissue Cells; D003593:Cytoplasm / Q000648:ultrastructure; D003782:Dental Pulp / Q000166:cytology* / Q000502:physiology; D007180:Incisor; D009804:Odontoblasts / Q000166:cytology; D013462:Sulfur Radioisotopes; D013997:Time Factors; D014090:Tooth Replantation; D014316:Tritium; D014945:Wound Healing
chemical_list: D013462:Sulfur Radioisotopes; D014316:Tritium