[Effect of calcium antagonists on the Ca2(+) paradox].
The model of calcium paradox was used to test the effect of the calcium entry blocker Diltiazem (concentration 4.0 mumol.l-1) and of the calmodulin inhibitor Trifluoroperazin (concentration 1.0 mumol.l-1). Application of each preparation resulted in improved cardiac function manifested by restoration of the electrical and contractile activity and by increased coronary flow. Both Diltiazem and Trifluoroperazin exerted a protective effect on the preservation of enzymatic activities and of ultrastructure in conditions of impaired calcium homeostasis.
Tribulová
N
N
Ustavu experimentálnej chirurgie CFV SAV v Bratislave.
Slezák
J
J
Ravingerová
T
T
Okruhlicová
L
L
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D004110:Diltiazem / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D014268:Trifluoperazine; D004110:Diltiazem; D002118:Calcium
Ovplyvnenie Ca2(+)-paradoxu antagonistami kalcia.