title: Effects of single-dose ultraviolet radiation on skin superoxide dismutase, catalase, and xanthine oxidase in hairless mice.
abstract: The effects of a single exposure to UVB radiation on skin antioxidant enzymes and superoxide-generating xanthine oxidase were examined in Skh:HR-1 hairless mice. Significant decreases in superoxide dismutase (SOD) and catalase (CAT) were observed by 12 h after UV irradiation and remained depressed for up to 72 h. No induction of xanthine dehydrogenase (XD) or xanthine oxidase (XO) occurred with UV treatment, although significant hyperplasia was evident. Ornithine decarboxylase was induced after UV irradiation as has been previously reported. These results demonstrate significant biochemical effects of a single dose of UVB on murine epidermis, especially in terms of antioxidant defenses.
authors.affiliation: Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430.
authors.forename: B C
authors.initials: BC
authors.lastname: Pence
authors.forename: M F
authors.initials: MF
authors.lastname: Naylor
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism / Q000528:radiation effects*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism / Q000528:radiation effects; D006965:Hyperplasia; D007700:Kinetics; D051379:Mice; D008812:Mice, Hairless; D009955:Ornithine Decarboxylase / Q000378:metabolism / Q000528:radiation effects; D012867:Skin / Q000201:enzymology* / Q000473:pathology / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays; D014969:Xanthine Oxidase / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D009955:Ornithine Decarboxylase