Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism.
The sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS), a potent chelating agent used in the treatment of inorganic and organic heavy metal intoxications was evaluated for developmental toxicity in pregnant Swiss mice. DMPS was administered by gavage at doses of 0, 75, 150 and 300 mg/kg per day on gestational days 6-15. Females were evaluated for body weight gain, food consumption, appearance and behavior, survival rates and reproduction data. Cesarean sections were performed on gestation day 18. There were no maternal toxic effects, and no treatment-related changes were recorded in the number of total implants, resorption, the number of live and dead fetuses, fetal body weight or fetal sex distribution data. Gross external, soft tissue and skeletal examination of the DMPS-treated fetuses did not show significant differences at any dose in comparison with the controls. Mineral analysis of maternal and fetal tissues revealed slight effects of DMPS on metabolism of calcium, magnesium, zinc, copper and iron. The results of this study in mice indicate that DMPS is not a developmental toxicant at levels up to 300 mg/kg per day.
Bosque
M A
MA
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, San Lorenzo, Spain.
Domingo
J L
JL
Paternain
J L
JL
Llobet
J M
JM
Corbella
J
J
D000014:Abnormalities, Drug-Induced / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004112:Dimercaprol / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D008431:Maternal-Fetal Exchange; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D014018:Tissue Distribution; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism*; D014494:Unithiol / Q000493:pharmacokinetics / Q000633:toxicity*
D014131:Trace Elements; D004112:Dimercaprol; D014494:Unithiol