title: [The treatment of blepharospasm with botulinum toxin A].
abstract: 12 patients suffering from essential blepharospasm were treated by injection of 4 ng botulinum toxin A into the Musculus orbicularis oculi of each eye. The effect was followed up over a period of 6 weeks by means of a subjective rating scale, a visual function score and a score for the overall clinical impression. After 4 days an improvement was observed in all patients and it was still present after 6 weeks. After a time interval of 12 weeks reinjection was performed in 8 cases with half the initial dose, since the beneficial effect had decreased to under 50%. Follow-up showed an impressive response to reinjection of botulinum toxin A, which remained undiminished still after 6 weeks. No serious side effects were observed. Hence, this form of therapy appears to be an effective alternative to all other therapeutic measures in this disease.
authors.affiliation: Neurologisch-Psychiatrische Abteilung, Krankenhaus der Barmherzigen Brüder, Graz-Eggenberg.
authors.forename: P
authors.initials: P
authors.lastname: Költringer
authors.forename: H
authors.initials: H
authors.lastname: Haselwander
authors.forename: F
authors.initials: F
authors.lastname: Reisecker
mesh_terms: D000328:Adult; D000368:Aged; D001764:Blepharospasm / Q000188:drug therapy*; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D005141:Eyelid Diseases / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000187:drug effects
chemical_list: D001905:Botulinum Toxins
vernacular_title: Die Behandlung des Blepharospasmus mit Botulinum-Toxin A.