title: In vitro susceptibility of Mycobacterium marinum to dihydromycoplanecin A and ten other antimicrobial agents.
abstract: The in vitro susceptibilities of 16 Mycobacterium marinum strains to 11 antimicrobial agents were determined by the Dubos Tween albumin liquid dilution technique. The results (MICs) were: 0.19-0.39 microgram/ml for dihydromycoplanecin A; 0.78-1.56 micrograms/ml for amikacin; 1.56-3.13 micrograms/ml for ofloxacin, norfloxacin and enoxacin; 1.56-6.25 micrograms/ml for minocycline; 1.56-25 micrograms/ml for sulfamethoxazole and sulfamethoxazole-trimethoprim; 3.13-12.5 micrograms/ml for oxytetracycline; 25-200 micrograms/ml for trimethoprim; and 50-200 micrograms/ml for pipemidic acid. The most active drugs were dihydromycoplanecine A and amikacin. Also active were minocycline, oxytetracycline, sulfamethoxazole and sulfamethoxazole-trimethoprim. Ofloxacin, norfloxacin and enoxacin demonstrated activity only at concentrations at or greater than those usually attained in serum. Pipemidic acid and trimethoprim were inactive.
authors.affiliation: Department of Dermatology, Yokohama City University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Kaminaga
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D006801:Humans; D066298:In Vitro Techniques; D007564:Japan; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D010455:Peptides; D010456:Peptides, Cyclic / Q000494:pharmacology; D012874:Skin Diseases, Infectious / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; D010456:Peptides, Cyclic; C055186:dihydromycoplanecin A