The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells.
In an investigation of the action of integerrimine on chromosomes, the bone marrow was taken as target organ. Male and female mice of the C57Bl/6 strain received a single acute dose of this pyrrolizidine alkaloid, in 2 concentrations: 18.75 and 37.50 mg/kg. Bone marrow cells were collected 6, 12 and 24 h after treatment. The analysis of metaphasic chromosomes demonstrated that chromosomal damage occurs, correlated with drug concentration. The greatest frequency of chromosomal aberrations was detected 12 h after treatment.
Gimmler-Luz
M C
MC
Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Erdtmann
B
B
Balbueno
R A
RA
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*
D011763:Pyrrolizidine Alkaloids; C009237:senecionine