title: Combination of dynamic and integral methods for generating reproducible functional CBF images.
abstract: A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, England.
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: V J
authors.initials: VJ
authors.lastname: Cunningham
authors.forename: M P
authors.initials: MP
authors.lastname: Deiber
authors.forename: J D
authors.initials: JD
authors.lastname: Heather
authors.forename: P M
authors.initials: PM
authors.lastname: Bloomfield
authors.forename: J
authors.initials: J
authors.lastname: Nutt
authors.forename: R S
authors.initials: RS
authors.lastname: Frackowiak
authors.forename: T
authors.initials: T
authors.lastname: Jones
mesh_terms: D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D010104:Oxygen Radioisotopes; D012016:Reference Values; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D010104:Oxygen Radioisotopes