Orange/black discolouration of the bowel (at laparotomy) due to clofazimine.
Clofazimine, a commonly used anti-lepromatous drug, is now being prescribed for the treatment of pyoderma gangrenosum, a complication of inflammatory bowel disease. This drug can cause an obstructive exacerbation of Crohn's disease. Surgeons should be aware of the orange/black discolouration of the bowel, which may mimic ischaemia macroscopically. A case, the first reported in Australia, is described and the literature discussed.
Merrett
M N
MN
Department of Gastroenterology, Prince Henry's Hospital, Melbourne, Victoria, Australia.
King
R W
RW
Farrell
K E
KE
Zeimer
H
H
Guli
E
E
D000328:Adult; D002991:Clofazimine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D011711:Pyoderma / Q000188:drug therapy*
D002991:Clofazimine