[Age-related dynamics of energy metabolism enzymes of neurons and microvessels of the brain in spontaneously hypertensive rats].
The age changes in the activity of some enzymes in neurons and in microvessels, revealed histochemically, as well as the volume of microvessels in spontaneously hypertensive (SH) rats differ from these changes in the controls. At the age of 3 months the activity of these enzymes and the number of active microvessels in SH rats increased. At the age of 6 months the activity of studied enzymes in SH rats decreased, while the number of active microvessels remained constant. The correlation between the morpho-functional characteristics of brain tissue in SH rats and its greater ischemic vulnerability is assumed.
Sorokoumov
V A
VA
Kisliakov
Iu Ia
IuIa
Pugacheva
E L
EL
Barantsevich
E R
ER
Grantyn'
V A
VA
D000612:4-Aminobutyrate Transaminase / Q000032:analysis; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002560:Cerebrovascular Circulation; D005993:Glycerolphosphate Dehydrogenase / Q000032:analysis; D006973:Hypertension / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008833:Microcirculation; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013385:Succinate Dehydrogenase / Q000032:analysis
D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000612:4-Aminobutyrate Transaminase; D000469:Alkaline Phosphatase
Vozrastnaia dinamika fermentov énergeticheskogo metabolizma neĭronov i mikrososudov golovnogo mozga spontanno gipertenzivnykh krys.