[The serum level of the secreted interleukin 2 receptor (sIL-2R): a lymphocyte activity parameter in sarcoidosis].
Current concepts of the immunopathology of sarcoidosis indicate that activated pulmonary T-lymphocytes play a central role in the maintenance of inflammatory processes. For the clinical management of the disease parameters which reflect the compartmentalized T-cell activation in the lung and which can be obtained from the peripheral blood are desired. Activated T-cells are known to release sIL-2R. Thus, we hypothesized that in pulmonary sarcoidosis disease activity could be monitored by the measurement of serum levels of sIL-2R. Our results demonstrate that disease activity is reflected more accurately by the serum level of sIL-2R than that of ACE, suggesting that phenomena of T-cell activation determining the course of the disease are monitored by this approach.
Müller-Quernheim
J
J
III. Med. Klinik-Schwerpunkt Pneumologie, Universitätskliniken Mainz.
Strausz
J
J
Ferlinz
R
R
D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012507:Sarcoidosis / Q000175:diagnosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015375:Receptors, Interleukin-2
Der Serumspiegel des sezernierten Interleukin-2-Rezeptors (sIL-2R): Ein lymphozytärer Aktivitätsparameter der Sarkoidose.