title: Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone (CRH)-like immunoreactivity in the rat.
abstract: The present study was designed to determine the effects of partial cholinergic denervation on parietal cortical corticotropin-releasing hormone-like immunoreactivity (CRH-LI) in the rat at different ages. Young adult rats received either unilateral or bilateral ibotenic acid infusions into their nucleus basalis, destroying most of the acetylcholinesterase-positive neurons in that region. Parietal cortical levels of CRH-LI were assayed 2.5, 10, 14 and 19 months after placement of nucleus basalis lesions. Parietal CRH-LI was elevated at 10, 14 and 19 months in bilaterally lesioned animals, while unilateral lesions had no effect on CRH-LI.
authors.affiliation: Department of Pharmacodynamics, University of Florida, Gainesville 32610.
authors.forename: W J
authors.initials: WJ
authors.lastname: Millard
authors.forename: G W
authors.initials: GW
authors.lastname: Arendash
authors.forename: A J
authors.initials: AJ
authors.lastname: Dunn
authors.forename: E M
authors.initials: EM
authors.lastname: Meyer
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001479:Basal Ganglia / Q000254:growth & development / Q000502:physiology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007051:Ibotenic Acid; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007051:Ibotenic Acid; D003346:Corticotropin-Releasing Hormone