In vivo IL-1 potentiates both specific and non-specific arms of immune response to infection.
Injection of 10(5) U interleukin-1 (IL-1) 4 hr before intravenous infection with Listeria monocytogenes hastens recovery of mice. This is accompanied not only by early stimulation of colony-forming cells in the spleen to levels higher than those in untreated, infected mice but also by accelerated activation of lymphokine-producing, specific T lymphocytes.
Cheers
C
C
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Zhan
Y F
YF
Egan
P J
PJ
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003114:Colony-Forming Units Assay; D007113:Immunity, Innate / Q000187:drug effects; D007375:Interleukin-1 / Q000494:pharmacology*; D008088:Listeriosis / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D011994:Recombinant Proteins