Peptide histidine methionine (PHM) increases vaginal blood flow in normal women.
The effect of increasing doses of PHM given subepithelially or intravenously on vaginal blood flow was studied. Vaginal blood flow was measured by a heated oxygen electrode, and the concentration of PHM in peripheral plasma was monitored radioimmunochemically. Injection of PHM induced a significant dose-dependent increase in vaginal blood flow. The flow values correlated with the plasma concentrations independent of the way of administration. The efficacy was the same as previously found for VIP but the potency of subepithelially injected PHM was found to be 10-fold lower than that of VIP. In conclusion, PHM and VIP seem to have similar vasodilatory effects upon vaginal blood flow.
Palle
C
C
Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen NV, Denmark.
Bredkjaer
H E
HE
Ottesen
B
B
Fahrenkrug
J
J
D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D010451:Peptide PHI / Q000502:physiology*; D012016:Reference Values; D012039:Regional Blood Flow; D014621:Vagina / Q000098:blood supply*
D010451:Peptide PHI