title: [Significance of the acetylator phenotype and initial oral/intravenous rifampicin administration in the treatment of tuberculosis].
abstract: In a pilot study involving 62 patients with open pulmonary tuberculosis, we established that slow acetyators and patients receiving intravenous rifampicin treatment showed a tendency towards a more rapid negativisation of the sputum culture than did fast acetyators (lower levels of isoniazid) or patients receiving oral rifampicin therapy (decreasing bioavailability of the rifampicin during treatment).
authors.affiliation: Medizinische Universitätsklinik Bonn.
authors.forename: U
authors.initials: U
authors.lastname: Loos
authors.forename: E
authors.initials: E
authors.lastname: Musch
authors.forename: H K
authors.initials: HK
authors.lastname: Schwabe
mesh_terms: D000107:Acetylation; D000284:Administration, Oral; D004977:Ethambutol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate / Q000502:physiology; D006899:Mixed Function Oxygenases / Q000235:genetics*; D010641:Phenotype; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D004977:Ethambutol; D006899:Mixed Function Oxygenases; D007538:Isoniazid; D012293:Rifampin
vernacular_title: Bedeutung des Azetyliererphänotyps und der initialen oralen/intravenösen Rifampicingabe in der Tuberkulosebehandlung.