Chemical characterization of acylpolyamine toxins from venom of a trap-door spider and two tarantulas.
Two acylpolyamines are identified from venom of the trap-door spider, Hebestatis theveniti. These toxins (paralytic to lepidopteran insect larvae) are amides containing 3-(3-indolyl)lactic acid joined to spermine or 1,13-diamino-4,10-diazatridecane (Het389 and Het403, respectively). Het389 is also abundant in venom from a tarantual from Mozambique (Harpactirella sp.). Two additional acylpolyamines (Apc600 and Apc728) are partially characterized from venom of another tarantula, Aphonopelma chalcodes.
Skinner
W S
WS
Sandoz Crop Protection Corporation, Research Division, Palo Alto, CA 94304.
Dennis
P A
PA
Lui
A
A
Carney
R L
RL
Quistad
G B
GB
D000818:Animals; D001180:Arthropod Venoms / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007211:Indoles / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D007915:Lepidoptera / Q000187:drug effects; D013058:Mass Spectrometry; D008970:Molecular Weight; D011073:Polyamines / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives / Q000494:pharmacology; D013111:Spider Venoms / Q000032:analysis*; D013112:Spiders; D014118:Toxins, Biological
D001180:Arthropod Venoms; C065317:Het 389 toxin; C065318:Het 403 toxin; D007211:Indoles; D011073:Polyamines; D013111:Spider Venoms; D014118:Toxins, Biological; D013096:Spermine