Can acetaminophen excess result in maternal and fetal toxicity?
This is the third case reported of maternal acetaminophen overdose during pregnancy. Such overdose may be associated with maternal liver toxicity. Fetal hepatotoxicity may be seen in association with maternal hepatotoxicity. As a result, the infant's blood coagulation times may be prolonged, and intracranial hemorrhage at delivery is a concern. Our case shows such a complication after chronic exposure to acetaminophen.
Kurzel
R B
RB
Department of Obstetrics and Gynecology, St. Louis University School of Medicine, St. Mary's Health Center, Mo.
D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced; D002543:Cerebral Hemorrhage / Q000097:blood / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000139:chemically induced*; D005323:Fetal Monitoring; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000097:blood; D008111:Liver Function Tests; D008431:Maternal-Fetal Exchange; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011517:Prothrombin Time
D000082:Acetaminophen