Multicentric reticulohistiocytosis in a patient with malignant melanoma: a response to cyclophosphamide and a unique cutaneous feature.
We describe a patient with multicentric reticulohistiocytosis and a history of malignant melanoma. His widely disseminated disease did not affect the site of surgical removal of the malignant melanoma nor the donor site of a skin graft. The multicentric reticulohistiocytosis progressed while the patient was taking nonsteroidal antiinflammatory agents, but showed significant response during a 10-month course of cyclophosphamide. While he was taking the cyclophosphamide, however, his melanoma recurred, and the patient subsequently died.
Kenik
J G
JG
Department of Internal Medicie, Creighton University School of Medicine, Omaha, Nebraska 68131.
Fok
F
F
Huerter
C J
CJ
Hurley
J A
JA
Stanosheck
J F
JF
D003520:Cyclophosphamide / Q000627:therapeutic use*; D015614:Histiocytosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications*; D008875:Middle Aged; D012156:Reticulocytes / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications*
D003520:Cyclophosphamide