title: [Low-grade B cell gastric lymphoma originated in mucosa-associated lymphoid tissue. Relationship of tumor cells with the marginal zone and monocytoid B lymphocytes. An immunohistochemical and ultrastructural study].
abstract: Seven cases of gastric B-cell low-grade lymphomas were characterized by morphology, immunohistology and electron microscopy. All them were immunophenotyped with a panel of monoclonal antibodies against immunoglobulins and other B-cell determinants. Histologic study of gastric B-cell low-grade lymphomas showed germinal centers of lobated shape and polyclonal nature, mainly polyclonal subepithelial plasma cell (except in one case) and neoplastic interfollicular B-cells of monoclonal character. Light-chain restriction supports the neoplastic nature of gastric lymphoma of low-grade malignancy, a distinctive tumour of extranodal B-cell origin. Interfollicular B-cells share with marginal zone cells a perifollicular localization, morphology and phenotype, suggesting a possible relation between these two cellular subtypes. In two cases, the tumour appears constituted by monocytoid B-lymphocytes (MBL), which suggests a relation of tumoral interfollicular B-cells with this subpopulation.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Virgen de la Salud, Toledo.
authors.forename: M A
authors.initials: MA
authors.lastname: Piris
authors.forename: C
authors.initials: C
authors.lastname: Rivas
authors.forename: M
authors.initials: M
authors.lastname: Morente
authors.forename: J L
authors.initials: JL
authors.lastname: Orradre
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
authors.forename: M A
authors.initials: MA
authors.lastname: Cruz
authors.forename: J L
authors.initials: JL
authors.lastname: Martínez
authors.forename: C
authors.initials: C
authors.lastname: Rubio
authors.forename: H
authors.initials: H
authors.lastname: Oliva
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D008221:Lymphoid Tissue; D008223:Lymphoma / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D000911:Antibodies, Monoclonal
vernacular_title: Linfoma B gástrico de bajo grado originado en tejido linfoide asociado a mucosas. Relación de las células tumorales con la zona marginal y los linfocitos B monocitoides. Estudio inmunohistoquímico y ultraestructural.