Proliferation rates of lymphocytes in subcutaneously transposed spleen and peripheral blood after heterotopic heart transplantation in rats.
In a transplantation model using Dark Agouti rats as heart donors and Lewis rats as recipients, mean graft survival time was 7.1 days in GII, receiving no immunosuppression, and 31.4 days in GIII, animals immunosuppressed by DSG. A higher percentage of Lb in the spleen than in the PB in the transplanted groups was detected on certain days. HCT sharply decreased in immunosuppressed animals, thus suggesting a reversible suppression of erythropoesis induced by DSG.
Kleinsasser
N
N
Institute for Surgical Research, University of Munich, FRG.
Krombach
F
F
Hammer
C
C
Brendel
W
W
D000818:Animals; D005260:Female; D006146:Guanidines / Q000627:therapeutic use; D016027:Heart Transplantation / Q000276:immunology* / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D016042:Transplantation, Heterotopic / Q000379:methods
D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus