[Effects of recombinant interleukin-2 on several characteristics of functional activity of lymphocytes from the lymph nodes regional to tumor and mononuclear cells of peripheral blood in cancer patients].
The level of endogenous production of IL-2 by lymphocytes of lymph nodes regional to tumour and by mononuclear cells of peripheral blood, proliferative response of these cell to recombinant IL-2, as well as a modifying influence of autologous serum and actively proliferating bioptats of autologous tumours on enumerated parameters have been studied in cancer patients (tumours of the head and neck and locomotor system). Regional IL-2-dependent immunotherapy of malignant tumors with obligatory preliminary testing for individual sensitivity of the tumor bioptat to the influence of the RIL-2 and RIL-2 activated lymphocytes is shown to be promising.
Semenova-Kobzar'
R A
RA
Kushko
L Ia
LIa
Iakhimovich
L V
LV
Protsyk
V S
VS
Tolstopiatov
B A
BA
Konovalenko
V F
VF
Berezhnaia
N M
NM
D000293:Adolescent; D000328:Adult; D000368:Aged; D005069:Evaluation Studies as Topic; D006258:Head and Neck Neoplasms / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000494:pharmacology* / Q000627:therapeutic use; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2
Vliianie rekombinantnogo interleĭkina-2 na nekotorye osobennosti funktsional'noĭ aktivnosti limfotsitov regionarnykh k opukholi limfaticheskikh uzlov i mononuklearnykh kletok perifericheskoĭ krovi onkologicheskikh bol'nykh.