title: [Nasal lymphoma of natural killer cell origin].
abstract: We report a case of nasal lymphoma with characteristics of natural killer (NH) cells. A 44-year-old man was admitted to our hospital because of right nasal obstruction. Physical examination revealed a tumor in the right nasal cavity and swelling of the right cervical lymph nodes. Histopathological examination showed diffuse medium sized cell lymphoma. The neoplastic cells expressed CD2, NKH-1, HLA-DR and leukocyte common antigen, but lacked other T-cell, B-cell and myeloid markers. They were in germline configuration for immunoglobulin heavy chain and T-cell receptor genes by southern blot analysis. These findings suggest that they are derived from NK cell.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Sekine
authors.forename: A
authors.initials: A
authors.lastname: Otsuji
authors.forename: N
authors.initials: N
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Kita
authors.forename: S
authors.initials: S
authors.lastname: Shirakawa
mesh_terms: D000328:Adult; D015321:Gene Rearrangement; D006801:Humans; D007694:Killer Cells, Natural; D008223:Lymphoma / Q000235:genetics / Q000473:pathology*; D008297:Male; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000235:genetics / Q000473:pathology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
chemical_list: D011948:Receptors, Antigen, T-Cell