title: Experimental reconstruction of the canine trachea with a free revascularized small bowel graft.
abstract: Extensive tracheal stenotic lesions caused by tracheomalacia or neoplasms represent a surgical challenge. Segmental tracheal substitution is sometimes required to obtain radical cure. We present an experimental study of 27 dogs undergoing replacement of the cervical trachea using a vascularized small bowel segment as a tubular graft. A silicone stent was placed in the lumen of the intestinal fragment and was removed the second week after operation. Endoscopic and histological examinations were performed between the first week and second month after operation, and rigidity of the graft was assessed in all cases. No evidence of anastomotic stricture or mucous formation was found. Microscopic examination showed the substitution of bowel mucosa by squamous epithelium as well as the development of connective tissue favoring the fixation of the skeletal muscular structures of the neck to the serous layer of the graft, thus avoiding collapse of the new airway.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Letang
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Lloret
authors.forename: J M
authors.initials: JM
authors.lastname: Gimferrer
authors.forename: J
authors.initials: J
authors.lastname: Ramírez
authors.forename: A
authors.initials: A
authors.lastname: Vicens
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D004285:Dogs; D004724:Endoscopy; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D007440:Intubation / Q000295:instrumentation; D009092:Mucous Membrane / Q000473:pathology; D012826:Silicone Elastomers; D015607:Stents; D013524:Surgical Flaps; D014132:Trachea / Q000473:pathology / Q000601:surgery*
chemical_list: D012826:Silicone Elastomers