[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
Using hybrid mice BDF1 doxorubicin (Dx) accumulation has been determined in leukemia P388 cells (P388/0), P388 cells with induced resistance to Dx (P388/Dx) and P388 cells with induced resistance to the finoptin (Fp) + Dx combination (P388/Fp + Dx). It has been shown that Fp doesn't affect Dx accumulation in or elimination from leukemia cells P388/0 or P388/Fp + Dx. The resistance of P388/Fp + Dx cells to the Fp + Dx combination develops during 6 passages. It can be concluded that Fp application doesn't abolish the problem of tumor cells' resistance to cytostatics.
Moroz
L V
LV
Donenko
F V
FV
Borovkova
N B
NB
Sitdikova
S M
SM
Kabieva
A O
AO
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004347:Drug Interactions; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology
D004317:Doxorubicin; D014700:Verapamil
Vliianie finoptina na nakoplenie doksorubitsina v kletkakh leĭkoza P-388 s indutsirovannoĭ ustoĭchivost'iu k kombinatsii finoptina s doksorubitsinom.