title: [The interaction of cytostatic compounds with urinary enzymes. 1. The influence on acylase from the human kidney].
abstract: Acylase, a cytosolic carboxypeptidase of human kidneys, is inhibited by various xenobiotics as well as by the physiological pH of human urine in the range of pH 4.5-5.8. Caused by this, the enzyme is unsuited for the demonstration of nephrotoxic processes.
authors.affiliation: Institut für Pathologische Biochemie, Bereichs Medizin der Martin-Luther-Universität Halle-Wittenberg.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hütter
authors.forename: R
authors.initials: R
authors.lastname: Pantschewa-Haschen
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000201:enzymology*; D015262:Xenobiotics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D015262:Xenobiotics; D000581:Amidohydrolases; C019665:amidase
vernacular_title: Die Wechselwirkung von cytostatischen Verbindungen mit Harnenzymen. 1. Mitteilung: Einfluss auf Acylase menschlicher Niere.