[Delta sleep-inducing peptide as a modulator of mediators acting on the heart].
Experiments on 51 isolated rabbit hearts have documented, that delta sleep-inducing peptide (6 X 10(-6) M/l) has a modulating effect on the mediators influencing the heart. This peptide enhances negative chronotropic effect of acetylcholine (1 X 10(-6) M/l) and decreases positive chronotropic effect of noradrenaline (1 X 10(-6) M/l). Such effect may be one of mechanisms of changes in the extracardiac regulation on the heart influenced by this peptide.
Ul'ianinskiĭ
L S
LS
Zviaginstseva
M A
MA
Kosharskaia
I L
IL
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology / Q000502:physiology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D007552:Isotonic Solutions; C037692:Tyrode's solution; D003701:Delta Sleep-Inducing Peptide; D000109:Acetylcholine; D009638:Norepinephrine
Peptid del'ta-sna kak moduliator deĭstviia mediatorov na serdtse.