title: [Trichosporon capitatum septicemia in immunosuppressed patients].
abstract: Disseminated Trichosporon capitatum infections are seldom reported. We observed 3 cases in leukemic patients within 4 months. All 3 patients were granulocytopenic. One of them was also treated with cyclosporine and methyl-prednisolone after an allogenic bone marrow transplant. The portal of entry was certainly the digestive tract as Tr. capitatum have been isolated in the stool before the septicemia. All 3 patients were previously treated with an azole antifungal compound. The part of this treatment in the emergence of Tr. capitatum in the digestive tract and in the occurrence of the septicemia must be considered. As Tr. capitatum are usually sensitive to the azole compounds the explanation may be a too low daily dosage for the treatment of severely immunocompromised hosts.
authors.affiliation: Service d'Onco-Hématologie, Hôpital de Hautepierre, Strasbourg.
authors.forename: R
authors.initials: R
authors.lastname: Herbrecht
authors.forename: K L
authors.initials: KL
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Koenig
authors.forename: J
authors.initials: J
authors.lastname: Waller
authors.forename: P
authors.initials: P
authors.lastname: Dufour
authors.forename: F
authors.initials: F
authors.lastname: Maloisel
authors.forename: J P
authors.initials: JP
authors.lastname: Bergerat
authors.forename: F
authors.initials: F
authors.lastname: Oberling
mesh_terms: D000328:Adult; D005260:Female; D015725:Fluconazole / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000139:chemically induced / Q000150:complications*; D018805:Sepsis / Q000139:chemically induced / Q000150:complications*; D014250:Trichosporon
chemical_list: D015725:Fluconazole; D007654:Ketoconazole
vernacular_title: Septicémies à Trichosporon capitatum chez des malades immunodéprimés.