Visual control of balance in cerebellar and parkinsonian syndromes.
The role of vision in the control of balance in patients with Parkinson's disease (PD) and cerebellar disease (CD) was studied by measuring body sway with eyes open, closed, and in response to visual stimuli generated by discrete lateral displacements of a moveable room which enclosed the subjects. In response to room movement, normal subjects swayed by an amount intermediate between sway with eyes open and eyes closed and their response attenuated on repetition of the movement, a process depending on shifting from predominantly visual to proprioceptive control. CD patients swayed more than controls with eyes open or closed and as shown by high 'Romberg quotients' (eyes closed/eyes open sway ratio) were able to use visual information to control much of their unsteadiness. CD patients had a normal attenuation of response to repetition of the room movement. PD patients had normal sway with eyes open or closed but their responses to room movement were abnormal, being proportionately larger and failing to attenuate during successive stimuli. The results indicate that cerebellar lesions seem largely to spare the visuopostural loop and also spare the ability to shift from a visual to a proprioceptive control of postural sway. In contrast, the findings in PD suggest that the visuopostural loop is hyperactive and that its influence cannot easily be de-emphasized when visual information is misleading. The latter finding suggests that basal ganglia participation in posture is concerned with the reweighting of the various sensorimotor loops controlling posture in the process of adapting to novel situations.
Bronstein
A M
AM
Medical Research Council Neuro-Otology Unit, Institute of Neurology, Queen Square, London, UK.
Hood
J D
JD
Gresty
M A
MA
Panagi
C
C
D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D002526:Cerebellar Diseases / Q000503:physiopathology*; D005583:Fourier Analysis; D006801:Humans; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000503:physiopathology*; D010775:Photic Stimulation; D004856:Postural Balance / Q000502:physiology*; D012016:Reference Values; D014202:Tremor / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology*