PDN-21: possible tumor marker for medullary thyroid carcinoma.
The plasma level of PDN-21 was measured by RIA in 10 patients with medullary thyroid carcinoma (MTC). All 10 patients with MTC had extremely elevated PDN-21 levels. The correlations between PDN-21, calcitonin gene-related peptide, and calcitonin, (all of which are calcitonin gene products) were significant (P less than .001) in the 10 MTC patients. This study suggests that PDN-21, as well as calcitonin, may be a useful marker for the detection of patients with MTC.
Takami
H
H
First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Shikata
J
J
Horie
H
H
Sekine
K
K
Ito
K
K
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D002277:Carcinoma / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011863:Radioimmunoassay; D012016:Reference Values; D013964:Thyroid Neoplasms / Q000097:blood*
D014408:Biomarkers, Tumor; D010446:Peptide Fragments; C037553:katacalcin; D002116:Calcitonin