[The long-term action of camphor on "audiosensitive" rats: electrophysiological research and mathematical modelling of the properties of the neuronal networks].
Rats of the Krushinskiĭ-Molodkina (KM) strain genetically predisposed to audiogenic seizures were repeatedly injected camphor for 4-5 months in gradually increasing doses (beginning from those below the seizure threshold up to those above it). As a result of "adaptation" to the convulsant action rats endured without seizures camphor doses 1.5-3 times higher than seizure threshold ones. Parallel with this "adaptation" the motor cortex of KM rats accumulated properties peculiar to the epileptic focus: spontaneous epileptiform spikes were recorded there after the camphor application. Estimation of the neural network parameters from spectra of the motor cortex biopotentials using the network model has shown a decrease of a parameter reflecting efficacy of the recurrent inhibition mechanisms. It is supposed that development of compensatory processes making rats able to avoid generalized camphor seizures are related to an increase of inhibitory functions of the caudate nucleus and weakening of the hippocampal excitability.
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D000161:Acoustic Stimulation; D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002164:Camphor / Q000494:pharmacology*; D004198:Disease Susceptibility / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008433:Mathematics; D008959:Models, Neurological; D009415:Nerve Net / Q000187:drug effects* / Q000503:physiopathology; D009420:Nervous System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*; D013997:Time Factors
D002164:Camphor
Dlitel'noe vozdeĭstvie kamforoĭ na "audiochuvstvitel'nykh" krys: élektrofiziologicheskoe issledovanie i matematicheskoe modelirovanie svoĭstv neĭronnykh seteĭ.