Heterotopic new bone formation causes resorption of the inductive bone matrix.
The bone matrix of growing rats was labeled by multiple injections of 3H-proline, and demineralized bone matrix (DBM) was prepared. The DBM was allotransplanted heterotopically into growing rats. New bone formation was induced in and around the implants. The new bone formation was accompanied by a decrease in the content of 3H; 20 and 30 days after implantation, 72% and 46%, respectively, of the activity remained in the implants. Daily injections of indomethacin (2 mg/kg) inhibited calcium uptake by about 20% at 20 and 30 days and inhibited the release of 3H from the DBM to a similar degree. Heterotopic bone induction by DBM is accompanied by matrix resorption, and inhibition of the new bone formation decreases the resorption of DBM.
Nilsson
O S
OS
Department of Orthopaedic Surgery, Karolinska Institute and Hospital, Stockholm, Sweden.
Persson
P E
PE
Ekelund
A
A
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001857:Bone Matrix / Q000378:metabolism* / Q000637:transplantation; D001862:Bone Resorption; D002118:Calcium / Q000037:antagonists & inhibitors; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011392:Proline / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D016042:Transplantation, Heterotopic; D014316:Tritium / Q000378:metabolism
D014316:Tritium; D011392:Proline; D002118:Calcium; D007213:Indomethacin