title: DNA demethylation in erythroleukaemia cells.
abstract: Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30-50% and this may be a contributory cause of the observed fall in CG methylation.
authors.affiliation: Department of Biochemistry, University of Glasgow, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Adams
authors.forename: A
authors.initials: A
authors.lastname: Hanley
authors.forename: A
authors.initials: A
authors.lastname: Rinaldi
mesh_terms: D000818:Animals; D001482:Base Composition; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism*; D015257:DNA-Cytosine Methylases / Q000378:metabolism; D004920:Erythropoiesis; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism*; D008745:Methylation; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D004247:DNA; D015257:DNA-Cytosine Methylases