title: [Spread and control of a methicillin-resistant Staphylococcus aureus in an academic hospital].
abstract: Between December 1988 and March 1989 twelve patients in the Utrecht University Hospital developed an infection with a methicillin-resistant Staphylococcus aureus (MRSA). Twenty other patients and 39 personnel members became colonized with the same MRSA strain. In spite of early isolation measures, progression of this epidemic was probably caused by the extreme degree of contagiousness of the first patient, who had a drug-induced allergic skin eruption. It seems likely that spread occurred via personnel and via a computer tomographic scanner. To contain the epidemic it was necessary to institute a special isolation ward with dedicated personnel. Although several MRSA strains have been introduced in the University Hospital since 1986, the strain we describe here is the only one which spread epidemically.
authors.affiliation: Afd. Medische Microbiologie en Laboratorium voor Infectieziekten, Academisch Ziekenhuis, Utrecht.
authors.forename: H M
authors.initials: HM
authors.lastname: Frénay
authors.forename: C M
authors.initials: CM
authors.lastname: Vandenbroucke-Grauls
authors.forename: T J
authors.initials: TJ
authors.lastname: Savelkoul
authors.forename: J H
authors.initials: JH
authors.lastname: Rommes
authors.forename: B
authors.initials: B
authors.lastname: van Klingeren
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
mesh_terms: D000046:Academic Medical Centers; D003428:Cross Infection / Q000382:microbiology*; D004196:Disease Outbreaks; D006801:Humans; D008712:Methicillin / Q000494:pharmacology*; D009426:Netherlands / Q000453:epidemiology; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D008712:Methicillin
vernacular_title: Verspreiding en bestrijding van een meticilline-resistente Staphylococcus aureus in een academisch ziekenhuis.