title: Inhibition of beta-glucuronidase in human urine by ascorbic acid.
abstract: The effects of oral supplementation of ascorbic acid (1500 mg d-1) on urinary beta-glucuronidase (beta-G) activity was assessed in a double-blind crossover study design over a 3-week period. The subjects on ascorbic acid treatment displayed a statistically significant (P less than 0.05) decrease in beta-G with an approximate decrease of 25%.
authors.affiliation: Environmental Health Sciences Program, School of Public Health, University of Massachusetts, Amherst 01003.
authors.forename: J C
authors.initials: JC
authors.lastname: Young
authors.forename: E M
authors.initials: EM
authors.lastname: Kenyon
authors.forename: E J
authors.initials: EJ
authors.lastname: Calabrese
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000652:urine; D004311:Double-Blind Method; D005966:Glucuronidase / Q000037:antagonists & inhibitors* / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010865:Pilot Projects; D011897:Random Allocation; D013997:Time Factors
chemical_list: D005966:Glucuronidase; D001205:Ascorbic Acid