title: Acute effects of electromagnetic stimulation of the brain on cortical activity, cortical blood flow, blood pressure and heart rate in the cat: an evaluation of safety.
abstract: The influence of repeated high intensity electromagnetic stimulation of the brain on cortical activity, cortical blood flow, blood pressure and heart rate has been investigated in the cat, to evaluate the safety of the method. The observations have been made in preparations under propofol anaesthesia before, during and after periods of anoxia. Electromagnetic stimulation of the brain evoked activity in descending motor pathways and was recorded by activity in the median nerve and by muscle twitches. Following repeated series of high intensity stimulation there were no systematic changes in somatosensory evoked potentials or background EEG, nor were there signs of epileptogenic activity during electromagnetic stimulation, before, during or after periods of anoxia. No systematic changes in cortical blood flow, blood pressure or heart rate were observed during electromagnetic stimulation, before or after periods of anoxia. In conclusion, no acute adverse consequences following electromagnetic stimulation in the normal and anoxic cat brain were demonstrated.
authors.affiliation: Department of Child Health, University of Newcastle upon Tyne, United Kingdom.
authors.forename: J A
authors.initials: JA
authors.lastname: Eyre
authors.forename: P A
authors.initials: PA
authors.lastname: Flecknell
authors.forename: B R
authors.initials: BR
authors.lastname: Kenyon
authors.forename: T H
authors.initials: TH
authors.lastname: Koh
authors.forename: S
authors.initials: S
authors.lastname: Miller
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply*; D004569:Electroencephalography; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D008475:Median Nerve / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*
chemical_list: D010100:Oxygen