title: [Bronchopulmonary penetration of ciprofloxacin].
abstract: We determined ciprofloxacin levels in plasma, saliva, bronchial secretions, lavage fluid, and alveolar macrophages in 9 patients five hours following the last administration of the drug (2 x 750 mg ciprofloxacin daily over a period of at least 3 days). The ciprofloxacin concentration in the alveolar film was determined using urea as internal marker for the lavage. On average it was 2.51 micrograms/ml (= 186% of the plasma level), and clearly exceeded the minimal inhibition concentrations for the facultative pathogenic organism. This means that, in the alveolar film--which represents the barrier to descending pneumonia--an effective accumulation of the quinolone takes place.
authors.affiliation: Medizinische Universitätsklinik Bonn.
authors.forename: U
authors.initials: U
authors.lastname: Loos
authors.forename: G
authors.initials: G
authors.lastname: Marklein
authors.forename: H
authors.initials: H
authors.lastname: Scholl
authors.forename: H K
authors.initials: HK
authors.lastname: Schwabe
mesh_terms: D001424:Bacterial Infections / Q000097:blood; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D011014:Pneumonia / Q000097:blood; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*
chemical_list: D002939:Ciprofloxacin
vernacular_title: Bronchopulmonale Penetration von Ciprofloxacin.