Kinetics of intravenously administered vitamin E in sheep and its biliary excretion.
This report describes studies of vitamin E kinetics and biliary excretions of vitamin E in 7 sheep administered [3H]-d-alpha-tocopherol (2 microCi/kg body weight) intravenously. Blood samples were periodically withdrawn from the jugular vein and bile samples from a biliary fistula for 56 h after intravenous administration of the [3H]-d-alpha-tocopherol. The kinetic data were modelled as 2-exchanging compartments. Radiovitamin E was rapidly distributed into the peripheral compartment and was widely distributed throughout the body. A high level of radioactivity was recorded in the lung, liver, spleen and renals. The concentrations of d-alpha-tocopherol in bile and plasma did not run parallel. The pattern of biliary radioactivity concentration suggests a rapid biliary clearance.
Hidiroglou
M
M
Animal Research Centre, Agriculture Canada, Ottawa, Ontario.
Ivan
M
M
Hidiroglou
N
N
D000818:Animals; D001646:Bile / Q000032:analysis* / Q000378:metabolism; D007262:Infusions, Intravenous / Q000662:veterinary; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D012756:Sheep / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*
D014810:Vitamin E