title: Intestinal obstruction at the onset of acute lymphoblastic leukemia in a child.
abstract: Surgical complications need not be fatal in acute leukemia. If these are promptly diagnosed and properly treated, the prognosis will improve. This report deals with a case of acute lymphoblastic leukemia presenting with an acute abdomen following surgery for choledochal cyst. A peripheral blood smear and examination of the bone marrow revealed acute lymphoblastic leukemia. The child received transfusions of blood and platelets. Pretreatment with prednisolone was started as therapy for leukemia, and 2 days later, the patient underwent surgery. Therapy was continued until the general condition allowed a more aggressive form of treatment. Complete remission was achieved, and the patient is still in good health 48 months after diagnosis and 15 months after discontinuation of treatment. The favorable outcome in this child shows that prompt surgery is sometimes an essential step in the treatment of childhood leukemia.
authors.affiliation: Third Department of Pediatrics, Policlinico Umberto I, University of Rome La Sapienza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Digilio
authors.forename: G
authors.initials: G
authors.lastname: Multari
authors.forename: B
authors.initials: B
authors.lastname: Werner
authors.forename: G
authors.initials: G
authors.lastname: Ballati
authors.forename: M
authors.initials: M
authors.lastname: Lemmo
authors.forename: A
authors.initials: A
authors.lastname: Sirignano
authors.forename: M
authors.initials: M
authors.lastname: Iacobini
authors.forename: M
authors.initials: M
authors.lastname: Roggini
authors.forename: F
authors.initials: F
authors.lastname: Cozzi
mesh_terms: D000006:Abdomen, Acute / Q000175:diagnosis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001803:Blood Transfusion; D002675:Child, Preschool; D015529:Choledochal Cyst / Q000150:complications / Q000601:surgery; D005260:Female; D006406:Hematoma / Q000150:complications; D006801:Humans; D007077:Ileal Diseases / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D007415:Intestinal Obstruction / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D007581:Jejunoileal Bypass; D007582:Jejunostomy; D017713:Platelet Transfusion; D011182:Postoperative Care; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D011300:Preoperative Care
chemical_list: D011239:Prednisolone