Competition between tuftsin and HBV S-protein sequences.
The syntheses of HBV S-protein partial sequences: Thr-Lys-Pro-Thr (I), Thr-Lys-Pro-Thr-Asp (II), and Thr-Lys-Pro-Thr-Asp-Gly (III) and also of pentapeptide Thr-Lys-Pro-Gly-Arg (IV), are described. For the peptides II and III inhibitory activity against tuftsin was found. Peptide IV (an analogue of tuftsin-inhibitor Thr-Lys-Pro-Pro-Arg) demonstrated a tuftsin-like activity in the phagocytosis experiments.
Siemion
I Z
IZ
Institute of Chemistry, Wrocław University, Poland.
Słoń
J
J
Nawrocka
E
E
Wieczorek
Z
Z
D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens; D066298:In Vitro Techniques; D007962:Leukocytes / Q000502:physiology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D014405:Tuftsin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000494:pharmacology
D006514:Hepatitis B Surface Antigens; D010446:Peptide Fragments; D014405:Tuftsin