Isochromosome 11q in acute monoblastic leukemia (M5a).
An isochromosome 11q in a patient with M5a type acute monoblastic leukemia is reported. The leukemic cells had a few azurophilic and alpha-naphthyl butyrate esterase-positive granules in the cytoplasm. Electron microscopy showed indented nuclei, abundant perinuclear fibrous bundles, and small lysosomes which were characteristic of monocytoid cells. A strong inhibitory activity against urokinase was detected in the cell lysates as compared with other leukemic cells. Cytogenetic analysis of the leukemic cells showed the karyotype 47, XY, +i(11q), which has not been observed hitherto in acute monocytic leukemia.
Niiya
K
K
Department of Medicine, Kochi Medical School, Japan.
Iwahara
Y
Y
Ishii
K
K
Takeuchi
T
T
Taguchi
H
H
Ohtsuki
Y
Y
Miyoshi
I
I
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D008854:Microscopy, Electron
D005819:Genetic Markers