[Changes in blood iron levels during cisplatin chemotherapy. Preliminary results].
Iron levels during cisplatin chemotherapy were evaluated in 23 neoplastic patients who received a total of 59 courses of cisplatin 80-100 mg/m2. In all cases hypersideraemia developed within 24 hours: iron mean value increased from 70.5 micrograms/dl to 237.4 micrograms/dl (p less than 0.001). Return to basal levels was achieved after 8-9 days. Indirect bilirubin, lactic-dehydrogenase, haemoglobin and red cells levels remained unmodified; reticulocyte count decreased only after 4 days, so making unlikely that a drug-induced haemolysis or a reduced iron utilization by inhibitory effect of cisplatin on erithron could be the cause of hypersideraemia, which at this moment remains unexplained.
Sartori
S
S
II Divisione di Medicina Generale e Servizio di Oncologia, Arcispedale S. Anna.
Nielsen
I
I
Malacarne
P
P
D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005293:Ferritins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D005293:Ferritins; D007501:Iron; D002945:Cisplatin
Variazioni del livello di sideremia durante chemioterapia con cisplatino. Risultati preliminari.