S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing.
The enzyme activities of S-adenosylhomocysteine hydrolase, adenosine deaminase and pyruvate kinase were determined in normal human erythrocytes subpopulations of different ages separated by centrifugation on a discontinuous Percoll:NaCl density gradient. The levels of S-adenosylhomocysteine hydrolase activity were found to undergo a sharp decrease with red cell ageing. Adenosine deaminase activities were, however, less critically dependent on erythrocyte age.
Bozzi
A
A
Department of Biochemical Sciences, University of Rome La Sapienza, Italy.
Furciniti-La Chiusa
B
B
Strom
R
R
Crifò
C
C
D000243:Adenosine Deaminase / Q000097:blood*; D043383:Adenosylhomocysteinase; D004905:Erythrocyte Aging / Q000502:physiology*; D004912:Erythrocytes / Q000201:enzymology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006867:Hydrolases / Q000097:blood*; D009700:Nucleoside Deaminases / Q000097:blood*; D011770:Pyruvate Kinase / Q000097:blood
D006454:Hemoglobins; D011770:Pyruvate Kinase; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase