title: In vitro studies of ciprofloxacin and survey of resistance patterns in current isolates.
abstract: We studied the activity of ciprofloxacin and other antibiotics against both routine and multiresistant (multi-R) clinical isolates. Ciprofloxacin inhibited more than 98% of most species of Enterobacteriaceae at a concentration of 2 micrograms/ml. Only Acinetobacter calcoaceticus, and to a much lesser degree, Providencia and Serratia, were resistant. Most Pseudomonas aeruginosa isolates were susceptible. Only 1% of staphylococci were resistant; the test panel included 1200 MRSA. For most species of streptococci, the MIC90 was 1 microgram/ml; for enterococci, it was 2 micrograms/ml. We also surveyed resistance in our current isolates. Resistance to ciprofloxacin has increased in A. calcoaceticus and Providencia, and in Streptococcus pneumoniae and group B streptococci. Ciprofloxacin-resistant isolates tended to show increased resistance to other antibiotics, including aminoglycosides and, later, cephalosporins.
authors.affiliation: Department of Microbiology, Royal North Shore Hospital, St. Leonards, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Fernandes
authors.forename: V P
authors.initials: VP
authors.lastname: Ackerman
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D011532:Providencia / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects*; D012705:Serratia / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
chemical_list: D002939:Ciprofloxacin