Effects of spaceflight on levels and activity of immune cells.
Experiments were carried out on cells from rats that had been flown on Soviet Biosputnik Cosmos 1887 to explore the effects of spaceflight on immune responses. Rat bone marrow cells were examined for their response to colony stimulating factor-M. Rat spleen and bone marrow cells were stained with antibodies directed against cell surface antigenic markers. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and interleukin-2 receptor cell surface antigens. A small increase in the percentage of cells staining positively for helper-T-cell antigens was also noted. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin.
Sonnenfeld
G
G
Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292.
Mandel
A D
AD
Konstantinova
I V
IV
Taylor
G R
GR
Berry
W D
WD
Wellhausen
S R
SR
Lesnyak
A T
AT
Fuchs
B B
BB
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects / Q000502:physiology; D000954:Antigens, Surface; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D001854:Bone Marrow Cells; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D007109:Immunity; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D014586:USSR
D000954:Antigens, Surface; D003115:Colony-Stimulating Factors