Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats.
Responses to adrenergic agents were measured on rings of mesenteric, artery of nonpregnant and pregnant rats at 21 days' gestation. In tissues from pregnant rats, norepinephrine, and phenylephrine were less sensitive than in rings from nonpregnant animals; maximum responses were not affected. The effect of isoproterenol was not modified in tissues from pregnant rats. The presence of endothelium in tissue rings was evaluated as fractional relaxation to acetylcholine. Sensitivity to phenylephrine and norepinephrine was inversely related to the effect of acetylcholine. This relationship was similar in slope in both groups but different in intercept. The sensitivity to isoproterenol was directly related to the presence of endothelium (curves similar in both slope and intercept). This demonstrates that the responses of mesenteric artery rings depends on the presence of endothelium. Furthermore, vascular endothelium is not involved in the blunted responses to adrenergic vasoconstrictor during pregnancy.
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Experimental Hypertension Laboratory, Clinical Research Institute of Montreal, Quebec, Canada.
Schiffrin
E L
EL
St-Louis
J
J
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008638:Mesenteric Arteries / Q000187:drug effects / Q000294:innervation*; D009638:Norepinephrine / Q000494:pharmacology; D009994:Osmolar Concentration; D010656:Phenylephrine / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013223:Statistics as Topic; D013564:Sympathetic Nervous System / Q000502:physiology*; D014661:Vasoconstriction; D014664:Vasodilation
D010656:Phenylephrine; D007545:Isoproterenol; D009638:Norepinephrine