title: A critical look at the TNM classification for laryngeal carcinoma.
abstract: A total number of 564 patients with glottic (427) and supraglottic (137) laryngeal carcinoma was prospectively staged clinicoendoscopically (CS) and radiologically (RS). These patients were treated from 1974 to 1985 with quality-controlled high-dose radiation therapy. The validity of CS versus RS was checked in this study with the parameter of recurrence-free adjusted survival (RFADS) at 3 and at 5 years. It appears that RS is more valid and has therapeutic implications in planning the target volume for irradiation. The CS should be regarded as inadequate for radiotherapeutic considerations. The International Union Against Cancer (UICC) 1987 norms for staging laryngeal carcinoma (clinical, endoscopic, and imaging) should be strictly followed.
authors.affiliation: Department of Radiation Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: A B
authors.initials: AB
authors.lastname: Karim
authors.forename: J H
authors.initials: JH
authors.lastname: Kralendonk
authors.forename: K H
authors.initials: KH
authors.lastname: Njo
authors.forename: J M
authors.initials: JM
authors.lastname: Tabak
authors.forename: G
authors.initials: G
authors.lastname: Gort
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005931:Glottis / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000145:classification* / Q000000981:diagnostic imaging / Q000532:radiotherapy; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011859:Radiography