title: Effects of FeSO4 on B16 melanoma cells differentiation and proliferation.
abstract: The effects exerted by FeSO4, in the presence or absence of vitamin C, on melanogenesis and proliferation in mouse B16 melanoma cells in culture were analysed either in serum-free (MEM-N2) or in serum-supplemented media. These cellular parameters can be either stimulated or on the contrary inhibited, depending on the metal concentration, the presence or the absence of vitamin C and serum, and on the type of culture (subconfluent or clonal). Vitamin C toxicity for B16 cells was decreased in the presence of FeSO4.
authors.affiliation: Department of Histology and Cytology, Faculty of Medicine, Université de Liège, Belgium.
authors.forename: M C
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.forename: B
authors.initials: B
authors.lastname: Siwek
authors.forename: G
authors.initials: G
authors.lastname: Pozzi
authors.forename: E
authors.initials: E
authors.lastname: Sabbioni
authors.forename: R J
authors.initials: RJ
authors.lastname: Bassleer
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D011232:Chemical Precipitation; D003470:Culture Media; D005296:Ferrous Compounds / Q000378:metabolism / Q000494:pharmacology*; D008543:Melanins / Q000032:analysis; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D003470:Culture Media; D005296:Ferrous Compounds; D008543:Melanins; C020748:ferrous sulfate; D001205:Ascorbic Acid