title: Time course of cycloplegia induced by a new phenylephrine-tropicamide combination drug.
abstract: A motorized and computer-interfaced phoropter was used to track the development of cycloplegia and recovery of accommodation over a 60-min period, after the topical application of a phenylephrine 5%-tropicamide 0.8% drug combination (Phenyltrope). Phenyltrope was introduced into the Canadian market about 2 years ago (Compendium of Pharmaceuticals and Specialties, 1987), and advertised as a fast acting cycloplegic and mydriatic drug. Here we report the results of our investigation of the depth of action and the temporal aspects of cycloplegia for this drug combination as a function of iris color. We also compare the action spectrum of Phenyltrope to that of tropicamide 1% under similar test conditions. Our results indicate that the latency for cycloplegia was shorter for tropicamide, the maximum rate of accommodative loss similar for both drugs, and the resultant cycloplegia at 20 min deeper for Phenyltrope. Recovery from induced cycloplegia was greater for tropicamide 60 min after drug administration. For both Phenyltrope and tropicamide, no significant differences in any of the parameters investigated were observed as a function of iris color. We conclude that even though Phenyltrope induced a measurably deeper cycloplegia than did tropicamide, the amount of residual accommodation present at 20 min (about 38%) is insufficient for most refractive purposes.
authors.affiliation: Université de Montréal, Ecole d'Optométrie, Montréal, Québec, Canada.
authors.forename: J V
authors.initials: JV
authors.lastname: Lovasik
authors.forename: H
authors.initials: H
authors.lastname: Kergoat
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects; D000287:Administration, Topical; D000328:Adult; D004338:Drug Combinations / Q000494:pharmacology; D005127:Eye Color / Q000187:drug effects; D005260:Female; D006801:Humans; D007498:Iris / Q000187:drug effects*; D008297:Male; D009184:Mydriatics / Q000008:administration & dosage; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D013997:Time Factors; D014331:Tropicamide / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D009184:Mydriatics; D011725:Pyridines; C064890:phenyltrope; D010656:Phenylephrine; D014331:Tropicamide