title: Determinants of pulmonary function in patients undergoing coronary bypass operations.
abstract: Pulmonary function testing was conducted consecutively in 29 healthy men (age range, 42 to 71 years) undergoing elective coronary artery bypass grafting. Lung volumes, expiratory flow rates, diffusing capacity, and blood gases were determined before operation, at discharge (8.7 +/- 1.9 days), and at 3 months postoperatively. In addition, peak expiratory flow rate was measured immediately after extubation (21.4 +/- 2.7 hours). Fifteen patients had smoked within the past year, but none had a history of pulmonary impairment. Twenty-two patients had internal mammary artery (IMA) dissection. Operation and recovery were uneventful in all cases. After extubation, peak expiratory flow rate was decreased by 65%. At discharge, lung volumes were decreased by 19% to 33% below preoperative values and expiratory flow rates were decreased by 33% to 37% below preoperative values. Some minor changes were detected at 3 months. Further analysis of these changes according to smoking history, age, preoperative weight, dissection of IMA, and aortic cross-clamp time showed that only IMA dissection affected the postextubation changes in peak expiratory flow rate (p less than 0.0001), whereas the decreases in functional residual capacity and expiratory reserve volume at discharge were affected by IMA dissection (p less than 0.05) and age (p = 0.01). Thus, median sternotomy is associated with severe but short-term pulmonary dysfunction; IMA dissection has a significant adverse effect on these changes.
authors.affiliation: Department of Surgery, Medical Center of Delaware, Wilmington 19713.
authors.forename: N
authors.initials: N
authors.lastname: Shapira
authors.forename: S M
authors.initials: SM
authors.lastname: Zabatino
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: D M
authors.initials: DM
authors.lastname: Murphy
authors.forename: D
authors.initials: D
authors.lastname: Sullivan
authors.forename: G M
authors.initials: GM
authors.lastname: Lemole
mesh_terms: D000367:Age Factors; D001835:Body Weight; D001026:Coronary Artery Bypass; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D011183:Postoperative Complications / Q000503:physiopathology*; D011300:Preoperative Care; D011653:Pulmonary Diffusing Capacity; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012907:Smoking / Q000009:adverse effects; D013249:Sternum / Q000601:surgery*