Imaging of acute myocardial infarction in pigs with Indium-111 monoclonal antimyosin scintigraphy and MRI.
Indium-111 antimyosin F(ab')2 was used in a series of scintigraphic studies on experimentally induced myocardial infarctions in pigs. Antimyosin distribution recorded by planar images of in vivo pigs and by single photon emission computed tomography (SPECT) of excised hearts delineated areas of myocardial necrosis if infarct volume exceeded 3.3 cm3. Scintigraphic images were compared with magnetic resonance images (MRI) obtained from excised hearts and with photographs of slices of the hearts. Infarct size and localization determined with antimyosin were compared. The MR images, with or without gadolinium-DTPA (Gd-DTPA), of the in vivo pigs were all false-negative; some myocardial wall thinning and high bloodpool signals were visible. Results show that both the antimyosin and the MR technique are specific methods for the visualization of induced myocardial necrosis in this animal model. However, the use of antimyosin is limited to a period ranging from 24 to 72 hours after infarction.
ten Kate
C I
CI
Department of Diagnostic Radiology (Division of Nuclear Medicine), University of Leiden, The Netherlands.
van Kroonenburgh
M J
MJ
Schipperheyn
J J
JJ
Doornbos
J
J
Hoedemaeker
P J
PJ
Maes
A
A
vd Nat
K H
KH
Camps
J A
JA
Huysmans
H A
HA
Pauwels
E K
EK
D000818:Animals; D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009942:Organometallic Compounds; D013552:Swine; D015899:Tomography, Emission-Computed, Single-Photon
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C058899:imciromab pentetate