A54145, a new lipopeptide antibiotic complex: microbial and chemical modification.
A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 complex was deacylated by Actinoplanes utahensis; three protected core peptides were isolated. A54145 antibiotic analogs were synthesized by acylation of the tryptophan N-terminus with 2,4,5-trichlorophenyl active esters, followed by deblocking with trifluoroacetic acid.
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Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
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Molloy
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Mynderse
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D000192:Actinomycetales / Q000378:metabolism; D000215:Acylation; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism; D008969:Molecular Sequence Data
C065208:A54145; D000900:Anti-Bacterial Agents; D008074:Lipoproteins