[Effect of defensin on the process of healing of aseptic skin wound and on the permeability of blood vessels].
It was shown, for the first time, that polypeptide of rabbit's neutrophils, defensin (D) has the ability to accelerate the reparation process (RP). D was infused intramuscular to rats (125 micrograms/kg) 2 days before the operation, then the skin on the back was dissected through all layers (the length of the wound was constant-10 mm). The rate of the RP was estimated by the changes of the wound length on 2, 5, 7, 13-15 days after the operation. The injection of D or physiological solution was continued during 2 weeks. It was shown, that beginning from the fifth postoperative day the RP in the experimental rats developed faster, than in control rats. In the experimental group the full reparation appeared earlier, than in the control group (on 21-22 and 24-26 days correspondingly. Qualitative (with trypan blue) and semi-quantitative (with colloid coal) methods have shown, that D augmented the permeability of blood vessels. It was proposed, that the RP acceleration was induced by D augmentation of the blood vessels permeability.
Kudriashov
B A
BA
Kondashevskaia
M V
MV
Liapina
L A
LA
Kokriakov
V N
VN
Mazing
Iu A
IuA
Shamova
O V
OV
D000818:Animals; D001798:Blood Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects* / Q000502:physiology; D023082:Defensins; D008297:Male; D008643:Mesentery / Q000098:blood supply; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014950:Wounds, Penetrating / Q000188:drug therapy*
D001798:Blood Proteins; D023082:Defensins
Deĭstvie defensina na protsess zazhivleniia asepticheskoĭ kozhnoĭ rany i na pronitsaemost' krovenosnykh sosudov.