Calcium carbonate exacerbates glomerular capillary hypertension and injury in rats with desoxycorticosterone-salt hypertension.
To examine the effects of dietary calcium supplementation on systemic and renal hemodynamics and glomerular injury in experimental hypertension, rats with desoxycorticosterone-salt hypertension were fed either standard chow, containing 1% calcium by weight, or chow supplemented with calcium carbonate to achieve a calcium content of 2% by weight. Ingestion of calcium carbonate failed to reduce systemic blood pressure, but was associated with increased proteinuria and morphologic evidence of glomerular injury. Micropuncture studies revealed that afferent arteriolar resistance was reduced and glomerular capillary pressure further increased in the high calcium group. Thus, calcium carbonate, in moderate amounts, not only failed to ameliorate systemic hypertension but, paradoxically, worsened intrarenal hypertension and injury in rats with mineralocorticoid-induced hypertension.
Dworkin
L D
LD
Department of Medicine, New York University Medical Center, New York 10016.
Feiner
H D
HD
Parker
M
M
Randazzo
J
J
D000818:Animals; D002119:Calcium Carbonate / Q000494:pharmacology*; D002196:Capillaries; D003900:Desoxycorticosterone; D006439:Hemodynamics; D006973:Hypertension / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D011507:Proteinuria / Q000652:urine; D011677:Punctures; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D002119:Calcium Carbonate