Comparative studies on the effect of vitamin A, B1 and B6 deficiency on oxalate metabolism in male rats.
The study was conducted to investigate the effect of vitamin A, B1 and B6 deficiency on oxalate metabolism in rats. A significant hyperoxaluria was the common observation in all the three vitamin deficiencies (vitamin B6 greater than vitamin A greater than vitamin B1). The activities of hepatic glycolate oxidase and glycolate dehydrogenase were markedly enhanced in vitamin-A- and vitamin-B6-deficient rats. However, lactate dehydrogenase levels remained unaltered in these deficiencies as compared to their respective pair-fed controls. Vitamin B1 deficiency of 4 weeks' duration could augment the activity of glycolate oxidase only, with no alterations in the glycolate dehydrogenase and lactate dehydrogenase levels. Intestinal oxalate uptake studies revealed increased bio-availability of oxalate from the gut in vitamin-A- and vitamin-B6-deficient rats. Thus, the results suggest the relative contribution of both exogenous as well as endogenous oxalate in the process of calculogenesis under various nutritional stress conditions in rat.
Sharma
S
S
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sidhu
H
H
Narula
R
R
Thind
S K
SK
Nath
R
R
D000818:Animals; D008297:Male; D010070:Oxalates / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000209:etiology / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*; D014804:Vitamin B Deficiency / Q000378:metabolism*
D010070:Oxalates