Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.
The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.
Pettit
G R
GR
Cancer Research Institute, Arizona State University, Tempe 85287.
Numata
A
A
Takemura
T
T
Ode
R H
RH
Narula
A S
AS
Schmidt
J M
JM
Cragg
G M
GM
Pase
C P
CP
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D010636:Phenols; D010946:Plants, Medicinal / Q000032:analysis*; D059808:Polyphenols
D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; C058956:acteoside; D059808:Polyphenols; C064683:isoacteoside