Deletions in chromosome 2 and fragile sites.
We report on 2 patients with de novo deletions of 2q and chromosome constitutions of 46,XY,del(2)(q32.3q33.3) and 46,XX,del(2) (q21q23.2), respectively. Comparisons of breakpoints of interstitial deletions show frequent correspondence to common fragile sites.
Palmer
C G
CG
Department of Medical Genetics, Indiana University, Indianapolis.
Heerema
N
N
Bull
M
M
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002889:Chromosomes, Human, Pair 2; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male