Increased levels of lipid peroxides in aged rat brain as revealed by direct assay of peroxide values.
Lipid peroxide concentrations in brain tissues of young and aged rats were determined by a direct method for measuring peroxide values. Three different brain regions were analyzed for lipid peroxides. The peroxide levels increased in all three regions of aged as compared to those of young rats, while lipid peroxides in plasma appeared to be stable along with age. Lipid peroxides in cerebrum and cerebellum increased 1.6-2.0 times in aged brains compared with young ones, and about 3-fold in the brain stem. Increased levels of lipid peroxides in aged brains seem not merely due to increased pools of precursor polyene fatty acids, but rather due to altered protection systems for lipid peroxidase formation.
Ando
S
S
Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, Japan.
Kon
K
K
Aino
K
K
Totani
Y
Y
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D008054:Lipid Peroxides