Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography.
The oral anticoagulant warfarin and its 14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance of levo-warfarin and its metabolites to be substantially slower than that of dextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines.
Szinai
I
I
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
Simonyi
M
M
Fitos
I
I
Tegyey
Z
Z
Magyar
A
A
D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013997:Time Factors; D014018:Tissue Distribution; D014859:Warfarin / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D014859:Warfarin