title: [Immunomodulators with an 8-azasteroid structure as inducers of liver cytochrome P-450].
abstract: Two structural analogues of D-homo-8-azasteroids, both an immunostimulant and an immunodepressant, are inductors of the liver cytochrome P-450 in animals. This capability was shown by means of both a decrease of the hexenal sleep duration in the pharmacological test and an increase of the quantity of cytochrome P-450 and the rate of N-demethylation of aminopyrine in the biochemical assays.
authors.forename: B B
authors.initials: BB
authors.lastname: Kuz'mitskiĭ
authors.forename: I G
authors.initials: IG
authors.lastname: Dad'kov
authors.forename: A E
authors.initials: AE
authors.lastname: Mashkovich
authors.forename: O V
authors.initials: OV
authors.lastname: Stoma
authors.forename: L M
authors.initials: LM
authors.lastname: Slepneva
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001378:Azasteroids / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013260:Steroids, Heterocyclic / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000276:Adjuvants, Immunologic; D001378:Azasteroids; D007166:Immunosuppressive Agents; D013260:Steroids, Heterocyclic; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D010634:Phenobarbital
vernacular_title: Immunomoduliatory 8-azasteroidnoĭ struktury kak induktory tsikhroma P-450.