title: Surgery for Crohn's disease in childhood: influence of site of disease and operative procedure on outcome.
abstract: Factors influencing outcome after surgery have been studied in 67 children requiring bowel resection or diversion of the faecal stream for Crohn's disease. Patients were divided into four groups on the basis of disease location at time of surgery, and mean follow-up was 4.5 years. All three children with panenteric disease (group 1) have relapsed. Best results were observed in cases with disease confined to the small bowel (group 2) and ileocaecal region (group 3), in whom surgery was followed by sustained remission in six out of seven and 24 out of 30 patients respectively. In the 27 children with colitis (group 4), results were mixed. Six of the seven patients who had staged colonic resections with a primary anastomosis relapsed, as did three out of four patients given a loop ileostomy to divert the faecal flow; in contrast, 15 out of 16 children who had a subtotal colectomy with ileostomy as the primary procedure have remained well, with only minor problems involving the rectal stump. An acceleration in growth velocity was observed during the first year after operation in 89 per cent of 40 children studied. Outcome after surgery for Crohn's disease in childhood depends mainly on disease location, but is influenced by the type of primary operation performed. In addition to symptomatic relief the principal early benefit of surgery is improved growth.
authors.affiliation: Department of Surgery, St. Bartholomew's Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Davies
authors.forename: C M
authors.initials: CM
authors.lastname: Evans
authors.forename: W S
authors.initials: WS
authors.lastname: Shand
authors.forename: J A
authors.initials: JA
authors.lastname: Walker-Smith
mesh_terms: D000293:Adolescent; D002432:Cecum / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000473:pathology / Q000601:surgery; D003424:Crohn Disease / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007422:Intestines / Q000601:surgery*; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies