title: Glutathione S-transferases in alcoholic liver disease.
abstract: There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.
authors.affiliation: Department of Pathology, University of Edinburgh.
authors.forename: D J
authors.initials: DJ
authors.lastname: Harrison
authors.forename: L
authors.initials: L
authors.lastname: May
authors.forename: P C
authors.initials: PC
authors.lastname: Hayes
authors.forename: M M
authors.initials: MM
authors.lastname: Haque
authors.forename: J D
authors.initials: JD
authors.lastname: Hayes
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase