Vasopressin-deficient paraventricular magnocellular neurons of homozygous Brattleboro rats synthesize neuropeptide Y.
Immunohistochemical study was carried out to determine whether neuropeptide Y (NPY), which was only found in certain experimental procedures in arginine vasopressin (AVP)-containing neurons of the magnocellular paraventricular nucleus, might also be synthesized in AVP-deficient homozygous Brattleboro (BB) rats. After an intraventricular colchicine administration, NPY was found in many AVP-deficient non-oxytocinergic magnocellular neurons of the paraventricular and supraoptic nuclei in BB rats, but not in suprachiasmatic nucleus neurons. The results suggest that the NPY synthesis is a phenotype of magnocellular non-oxytocinergic neurosecretory neurons and occurs independently from the synthesis of AVP.
Kagotani
Y
Y
Department of Anatomy, School of Medicine, University of Tokushima, Japan.
Hisano
S
S
Tsuruo
Y
Y
Daikoku
S
S
Chihara
K
K
D000818:Animals; D009478:Neuropeptide Y / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro / Q000378:metabolism*; D011922:Rats, Mutant Strains / Q000378:metabolism*; D014667:Vasopressins / Q000172:deficiency*
D009478:Neuropeptide Y; D014667:Vasopressins