title: Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.
abstract: Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.
authors.affiliation: Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
authors.forename: B B
authors.initials: BB
authors.lastname: Knowles
authors.forename: J
authors.initials: J
authors.lastname: McCarrick
authors.forename: N
authors.initials: N
authors.lastname: Fox
authors.forename: D
authors.initials: D
authors.lastname: Solter
authors.forename: I
authors.initials: I
authors.lastname: Damjanov
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics* / Q000378:metabolism; D001859:Bone Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D003001:Cloning, Molecular; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011401:Promoter Regions, Genetic; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology; D000516:alpha-Amylases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000952:Antigens, Polyomavirus Transforming; D000516:alpha-Amylases