[An experimental and clinical study of the analgesic action of clofelin when administered epidurally].
Clonidine and its Soviet-made analogue clopheline (10 micrograms) after epidural administration to rats equally inhibited nociceptive reactions and changes in arterial blood pressure in the somatic and visceral pain tests. In patients with obliterating atherosclerosis of the lower extremities clopheline (100 and 200 micrograms) relieved the pain syndrome and shifts of II-hydroxycorticosteroids in blood, induced bradycardia and the background arterial blood pressure-dependent antihypertensive effect.
Ignatov
Iu D
IuD
Zaĭtsev
A A
AA
Strashnov
V I
VI
Dzhaberi
M
M
Khnykina
V I
VI
D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural / Q000379:methods*; D000818:Animals; D001162:Arteriosclerosis Obliterans / Q000503:physiopathology / Q000628:therapy; D003000:Clonidine / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D051381:Rats
D003000:Clonidine
Eksperimental'no-klinicheskoe izuchenie boleutoliaiushchego deĭstviia klofelina pri épidural'nom vvedenii.