title: Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy.
abstract: Six patients with newly diagnosed haematological malignancy were treated with ciprofloxacin 500 mg orally, as chemoprophylaxis during neutropenia. The mean serum ciprofloxacin concentrations, measured 1, 2, 3 and 4 h after dosage were reduced for up to ten days after the start of chemotherapy. The mean maximum serum concentration and AUC 0-4 h were reduced from 3.7 (95% confidence limits, 2.3-5.1) mg/l and 10.7 (6.2-15.2) mg/l.h pre-chemotherapy to 2.0 (1.4-2.6) mg/l and 5.7 (4.4-7.0) mg/l.h, 13 days after chemotherapy. Absorption of ciprofloxacin is reduced after cytotoxic chemotherapy, and this may have implications for the use of oral ciprofloxacin in this group of patients.
authors.affiliation: Department of Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Johnson
authors.forename: A P
authors.initials: AP
authors.lastname: MacGowan
authors.forename: M N
authors.initials: MN
authors.lastname: Potter
authors.forename: R J
authors.initials: RJ
authors.lastname: Stockley
authors.forename: L O
authors.initials: LO
authors.lastname: White
authors.forename: R R
authors.initials: RR
authors.lastname: Slade
authors.forename: D S
authors.initials: DS
authors.lastname: Reeves
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D002939:Ciprofloxacin