Coexistence of CRF peptide and oxytocin mRNA in the paraventricular nucleus.
Several studies have reported coexistences of peptides in parvocellular neurons of the paraventricular nucleus (PVN). However, the coexistence of peptides in the magnocellular PVN is less clear. Controversy exists in particular about the coexistence of corticotropin-releasing factor (CRF) and oxytocin (OX). Although these peptides are present in distinct areas of the PVN, some overlap may exist. This study investigated a potential coexistence of OX and CRF in magno- and parvocellular PVN. The data demonstrate with clarity that neurons containing both the mRNA for OX and the peptide CRF are present in subpopulations of magnocellular and parvocellular neurons of the PVN.
Pretel
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Neuroendocrine Unit, University of Rochester, School of Medicine and Dentistry, NY 14642.
Piekut
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DT
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D007150:Immunohistochemistry; D008297:Male; D009693:Nucleic Acid Hybridization; D010121:Oxytocin / Q000235:genetics*; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis*; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D012333:RNA, Messenger; D010121:Oxytocin; D003346:Corticotropin-Releasing Hormone