[The protective action on the myocardium of antihypoxants in acute occlusion and subsequent reperfusion of the coronary artery].
In experiments on anesthetized cats with acute occlusion of the coronary artery followed by its reperfusion antihypoxants piracetam, lithium hydroxybutyrate and pyrid oxynyl-glyoxylate (glyo-6) were shown to stabilize the contractile and pumping functions of the heart. GABA derivatives piracetam and lithium hydroxybutyrate in contrast to glyo-6 were found not only to stimulate the compensatory processes in the conventional intact area of the ischemized left ventricle but also improve the energy metabolism in the ischemic focus itself.
Lomtadze
D M
DM
Tsorin
I B
IB
Chirkova
E Iu
EIu
Chichkanov
G G
GG
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006885:Hydroxybutyrates / Q000627:therapeutic use; D000860:Hypoxia / Q000503:physiopathology / Q000517:prevention & control*; D008094:Lithium / Q000627:therapeutic use; D015425:Myocardial Reperfusion; D009942:Organometallic Compounds / Q000627:therapeutic use; D010889:Piracetam / Q000627:therapeutic use; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000627:therapeutic use
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C001310:pyridoxilate; C022826:lithium hydroxybutyrate; D008094:Lithium; D011736:Pyridoxine; D010889:Piracetam
Zashchitnoe deĭstvie na miokard nekotorykh antigiposantov v usloviiakh ostroĭ okkliuzii i posleduiushcheĭ reperfuzii koronarnoĭ arterii.