Influence of glycine on morphine-induced antinociception in mice.
The effects of glycine on morphine-induced antinociception were investigated in mice, using a cutaneous thermal test (hot-plate), a visceral chemical test (acetylcholine writhing test), and a locomotor activity test. When glycine (200 mg/kg p.o.) and morphine (5 mg/kg s.c.) were given together during the first 30 min, glycine first antagonized the morphine-induced antinociception then this was followed by a synergistic effect. The two-phase influence of glycine on morphine-induced antinociception may be due to the interaction of glycine with different receptors.
Carrara
M
M
Department of Pharmacology, University of Padova, Italy.
Zampiron
S
S
Capolongo
F
F
Cima
L
L
Giusti
P
P
D000109:Acetylcholine; D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D005998:Glycine / Q000494:pharmacology*; D006358:Hot Temperature; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity; D010146:Pain / Q000139:chemically induced
D000700:Analgesics; D009020:Morphine; D000109:Acetylcholine; D005998:Glycine