title: Cardiac resuscitability with cardiopulmonary bypass after increasing ventricular fibrillation times in dogs.
abstract: Previous studies in dogs have shown resuscitation from prolonged cardiac arrest to conscious survival to be more effective with the use of cardiopulmonary bypass (CPB) than with standard advanced cardiac life support. This study compared cardiovascular resuscitability with CPB only after varying periods of cardiac arrest without artificial circulatory support in a canine model. Group 1 (ten) was subjected to ventricular fibrillation for 15 minutes; group 2 (ten) for 20 minutes; and group 3 (ten) for 30 minutes. All received total CPB after ventricular fibrillation without advanced cardiac life support to defibrillation at two to five minutes and partial CPB to four hours. In all three groups CPB with epinephrine generated normal coronary perfusion pressure and increased ventricular fibrillation amplitude significantly. In groups 1 and 2, CPB reperfusion allowed for successful defibrillation in less than five minutes, weaning from CPB in all dogs at four hours, and stable spontaneous circulation thereafter. In group 3, only five of ten dogs could be weaned from bypass at four hours, and all died early with myocardial necroses. It was concluded that CPB may be of value in the setting of prolonged cardiac arrest when advanced cardiac life support has not been provided or is unable to restore spontaneous heart-beat.
authors.affiliation: International Resuscitation Research Center, University of Pittsburgh, Pennsylvania 15260.
authors.forename: H
authors.initials: H
authors.lastname: Reich
authors.forename: M
authors.initials: M
authors.lastname: Angelos
authors.forename: P
authors.initials: P
authors.lastname: Safar
authors.forename: F
authors.initials: F
authors.lastname: Sterz
authors.forename: Y
authors.initials: Y
authors.lastname: Leonov
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D003327:Coronary Disease / Q000628:therapy*; D004285:Dogs; D004554:Electric Countershock; D006323:Heart Arrest / Q000628:therapy*; D015425:Myocardial Reperfusion; D012151:Resuscitation / Q000379:methods*; D014693:Ventricular Fibrillation / Q000628:therapy*