title: [The polymorphism of the pharmacological effects of calcium channel blockers].
abstract: In experiments on mice and rats it was shown that the studied calcium channel blockers--verapamil (finoptin, isoptin), nifedipine (corinfar), sensit (phendilin), cinnarizine (stugeron), diltiazem--are heterogeneous by their pharmacological properties. No relationships between the antiarrhythmic, anticonvulsant and cholinolytic effects of the compounds were revealed. It was supposed that the cholinolytic activity of nifedipine and diltiazem in arecoline salivation test reflects not their competitive relations with acetylcholine on the active surface of the receptor, but rather is realized at the level of the signal transmembrane transmission systems.
authors.forename: T M
authors.initials: TM
authors.lastname: Ivanova
authors.forename: N P
authors.initials: NP
authors.lastname: Podosinovikova
authors.forename: V B
authors.initials: VB
authors.lastname: Dolgo-Saburov
authors.forename: M B
authors.initials: MB
authors.lastname: Predtechenskiĭ
authors.forename: N A
authors.initials: NA
authors.lastname: Stepanova
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D001115:Arecoline / Q000506:poisoning; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D051379:Mice; D010276:Parasympatholytics; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D010276:Parasympatholytics; D001115:Arecoline
vernacular_title: Polimorfizm farmakologicheskikh éffektov blokatorov kal'tsievykh kanalov.