title: Induction of pregnancy-associated murine protein-1 in dwarf mice by human growth hormone.
abstract: Pregnancy-associated murine protein-1 (PAMP-1) could not be detected in peripheral blood of female dwarf mice (genotype dw/dw of the DW strain). By contrast the normal size females of the DW strain (genotypes +/+ and +/dw) had PAMP-1 serum levels of 18.9 AU +/- 15.7 AU/ml. Following administration of biosynthetic human growth hormone (hGH) every 2 h for 52 h PAMP-1 was detected in all dwarf females at concentrations of 16.0 AU +/- 3.3 AU/ml. The albumin levels in the circulation of DW females of normal size were significantly higher (P less than 0.05) than those of DW dwarfs, and the hGH administration did not change the serum albumin levels. The present experiment adds weight to the suggestion that the PAMP-1 serum level is regulated by GH.
authors.affiliation: Department of Veterinary Pathology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Hau
authors.forename: O M
authors.initials: OM
authors.lastname: Poulsen
authors.forename: N F
authors.initials: NF
authors.lastname: Dagnaes Hansen
authors.forename: K R
authors.initials: KR
authors.lastname: Worm
mesh_terms: D000818:Animals; D004392:Dwarfism / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D006062:Gonadotropins / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D011257:Pregnancy Proteins / Q000096:biosynthesis* / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D006062:Gonadotropins; D011257:Pregnancy Proteins; D012709:Serum Albumin; C033484:pregnancy-associated murine protein 1