[Multiple liver abscesses due to Candida albicans in a patient with acute promyelocytic leukemia: percutaneous transhepatic intraportal administration of amphotericin B].
A 36-year-old male with acute promyelocytic leukemia in second relapse was admitted to receive reinduction therapy in June, 1985, and entered into third complete remission, but he developed spiky fever after chemotherapy. Ultrasonic tomography revealed multiple liver abscesses and culture of the aspirates demonstrated Candida albicans in the abscesses. He was treated with intravenous administration of amphotericin B (AMPH-B) but the effect on the liver abscesses was unsatisfactory and consolidation therapy was difficult to start. AMPH-B (30 mg/day) was administered by percutaneous transhepatic intraportal administration (PTIA). About two months later, multiple liver abscesses disappeared. No remarkable complications such as severe fever, chill and renal dysfunction were recognized during PTIA of AMPH-B. So PTIA of AMPH-B is considered to be useful and safe for the management of fungal liver abscesses.
Ishii
H
H
Second Department of Internal Medicine, Chiba University School of Medicine.
Hiruma
K
K
Morio
S
S
Hirasawa
A
A
Wakita
H
H
Endoh
N
N
Oh
H
H
Yoshida
S
S
Aotsuka
N
N
Asai
T
T
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D002177:Candidiasis; D002404:Catheterization; D003561:Cytarabine / Q000008:administration & dosage; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D008100:Liver Abscess / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011168:Portal System
D003561:Cytarabine; D000666:Amphotericin B