[Electron microscopy study of amorolfin action against Malassezia furfur (Robin) Baillon].
During 48 hours, yeasts (Malassezia furfur) are brought into contact with a new antifungal agent of broad antifungal spectrum, amorolfine, used with the following concentrations: 0.1, 0.5, 1, 2, 5, 10 micrograms/ml. After centrifugation, pellets are fixed, using the conventional technique of electron microscopy. Although the cell wall seems intact, the changes observed at the level of the cytoplasm and of the cell organels can be compared to those observed in blastospores of C. albicans. This analogy of activity of amorolfine and of azole derivatives is discussed.
Moulin-Traffort
J
J
Laboratoire de Botanique et Cryptogamie, Faculté de Pharmacie, Marseille.
Goudard
M
M
Regli
P
P
D000935:Antifungal Agents / Q000494:pharmacology*; D008290:Malassezia / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009025:Morpholines / Q000494:pharmacology*
D000935:Antifungal Agents; D009025:Morpholines; C038974:amorolfine
Etude en microscopie électronique de l'action de l'amorolfine sur Malassezia furfur (Robin) Baillon.