Nuclear and "cytoplasmic" estrogen and progesterone receptors in squamous cell carcinoma of the cervix.
Biopsies from 131 women with squamous cell carcinoma of the cervix diagnosed between May 1983 and July 1986 were assayed for nuclear and "cytoplasmic" estrogen receptors (NER and CER). Progesterone receptors (PR) were also assayed in 45 of these tumors. About a third of the tumors contained both CER and NER. One or the other fraction contained ER in 76.9% of cases and PR in 66.6%. Although there was a trend for those women whose tumors contained CER or NER to have a better prognosis, this was not significant. There was no evidence that PR status affected the prognosis.
Darne
J
J
University Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield, England.
Soutter
W P
WP
Ginsberg
R
R
Sharp
F
F
D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000401:mortality; D002467:Cell Nucleus / Q000032:analysis; D003593:Cytoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000401:mortality
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone