title: Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome.
abstract: Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italia.
authors.forename: S
authors.initials: S
authors.lastname: Scappaticci
authors.forename: A
authors.initials: A
authors.lastname: Forabosco
authors.forename: G
authors.initials: G
authors.lastname: Borroni
authors.forename: G
authors.initials: G
authors.lastname: Orecchia
authors.forename: M
authors.initials: M
authors.lastname: Fraccaro
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002999:Clone Cells / Q000648:ultrastructure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D014898:Werner Syndrome / Q000235:genetics*