title: Clinical, biochemical and immunoelectron microscopical evidence of dual hormone production in a mammosomatotroph cell adenoma.
abstract: This paper reports the occurrence of a rare, yet distinct pituitary adenoma which was surgically removed from a 42-year-old male with both clinical and biochemical evidence of acromegaly and mild hyperprolactinaemia. The monomorphic adenoma consisted of mature cells which were ultrastructurally indistinguishable from those of a prolactinoma. Electron immunocytochemistry, including a series of double-labelling techniques using selected colloidal gold particles as markers, indicated the presence of a pituitary adenoma in which the cells were capable of simultaneously producing growth hormone and prolactin and packaging them within the same secretory granule. This is thought to represent a mammosomatotroph cell adenoma.
authors.affiliation: Department of Pathology, Queen's University, Belfast, Northern Ireland, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Cameron
authors.forename: I
authors.initials: I
authors.lastname: Allen
authors.forename: C
authors.initials: C
authors.lastname: Ozo
authors.forename: L
authors.initials: L
authors.lastname: Kennedy
authors.forename: B
authors.initials: B
authors.lastname: Atkinson
authors.forename: D
authors.initials: D
authors.lastname: Hadden
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000648:ultrastructure; D000328:Adult; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism*
chemical_list: D011388:Prolactin; D013006:Growth Hormone