Pradimicins A, B and C: new antifungal antibiotics. I. Taxonomy, production, isolation and physico-chemical properties.
New antifungal antibiotics, pradimicins A, B and C were isolated from the culture broth of actinomycete strains proposed as Actinomadura hibisca. They are orange to red pigments containing a benzo[a]naphthacenequinone chromophore substituted with a D-alanine, an aminosugar and a D-xylose (pradimicins A and C).
Tomita
K
K
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Nishio
M
M
Saitoh
K
K
Yamamoto
H
H
Hoshino
Y
Y
Ohkuma
H
H
Konishi
M
M
Miyaki
T
T
Oki
T
T
D000192:Actinomycetales / Q000145:classification / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056806:benanomicin B; D000095643:Pradimicins and Benanomicins; C058036:pradimicin A; C058037:pradimicin B