title: Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation.
abstract: Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-induced cirrhosis and recurrent variceal hemorrhage. She underwent successful orthotopic liver transplant. Her postoperative course was uncomplicated, with no evidence of rejection or recurrence of graft-vs.-host disease. As bone marrow transplantation is more widely used and survival improves, the number of patients with graft-vs.-host disease or venoocclusive disease resulting in cirrhosis is likely to increase. Hepatic transplantation should be considered for bone marrow transplant patients who develop end-stage liver disease.
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston.
authors.forename: D F
authors.initials: DF
authors.lastname: Rhodes
authors.forename: W M
authors.initials: WM
authors.lastname: Lee
authors.forename: J R
authors.initials: JR
authors.lastname: Wingard
authors.forename: M D
authors.initials: MD
authors.lastname: Pavy
authors.forename: G W
authors.initials: GW
authors.lastname: Santos
authors.forename: B W
authors.initials: BW
authors.lastname: Shaw
authors.forename: R P
authors.initials: RP
authors.lastname: Wood
authors.forename: M F
authors.initials: MF
authors.lastname: Sorrell
authors.forename: R S
authors.initials: RS
authors.lastname: Markin
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004932:Esophageal and Gastric Varices / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006086:Graft vs Host Disease / Q000209:etiology / Q000601:surgery*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008103:Liver Cirrhosis / Q000209:etiology; D016031:Liver Transplantation