title: Thermodynamic effects of bile acids in the stomach.
abstract: The surface thermodynamic effects of bile acids in the stomach were assessed in 48 subjects who had undergone gastric surgery for peptic ulcer disease and in 52 controls with medically healed ulcers. We derived values for surface tension of gastric mucosa from contact angle using a goniometer and measured the surface tension of gastric juice by the drop-weight method. Subjects with gastric surgery had higher median fasting bile acid concentrations than controls (1.2 vs. 0.1 mmol/L; P less than 0.0001), higher mean mucosal surface tension (51.9 vs. 47.9 mN/m; P less than 0.0001), and lower mean surface tension of gastric juice (43.2 vs. 51.7 mN/m; P less than 0.0001). Subjects who had had a Billroth II gastrectomy (n = 19) had higher bile acid concentrations (5.8 vs. 0.6 mmol/L; P less than 0.01), higher mucosal surface tension (53.7 vs. 50.3 mN/m; P less than 0.05), and lower gastric juice surface tension (41.3 vs. 47.1 mN/m; P less than 0.05) than those who had a vagotomy and drainage procedure (n = 17). Overall, intragastric bile acid concentration correlated directly with surface tension of gastric mucosa (r = 0.51, P less than 0.0001) and inversely with that of gastric juice (r = -0.60, P less than 0.0001). In conclusion, the interfacial energy barrier at the surface of the gastric mucosa is overcome in the presence of intragastric bile acids.
authors.affiliation: Department of Medicine, St. George's Hospital Medical School, Tooling, London, England.
authors.forename: R T
authors.initials: RT
authors.lastname: Spychal
authors.forename: R S
authors.initials: RS
authors.lastname: Savalgi
authors.forename: J M
authors.initials: JM
authors.lastname: Marrero
authors.forename: S H
authors.initials: SH
authors.lastname: Saverymuttu
authors.forename: J S
authors.initials: JS
authors.lastname: Kirkham
authors.forename: T C
authors.initials: TC
authors.lastname: Northfield
mesh_terms: D001647:Bile Acids and Salts / Q000494:pharmacology*; D005743:Gastrectomy; D005750:Gastric Juice / Q000502:physiology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D013500:Surface Tension; D013816:Thermodynamics; D014628:Vagotomy
chemical_list: D001647:Bile Acids and Salts