[Results of conversion from conventional immunosuppressive therapy to cyclosporin A in complications following kidney transplantation].
In 41 patients suffering from complications late after kidney transplantation the conventional immunosuppression was converted to Cyclosporin A. A complete normalization was obtained in the case of acquired immunoglobulin G deficiency and in persistent leukocytopenia. 6 patients suffering from life-threatening bacterial infections did survive after conversion with functioning allograft and 8 out of 9 late rejections were reversible. Conversion may be necessary in chronic hepatopathy and chronic rejection. A conversion to cyclosporin A is recommended because of control of complications in 78% (46/59) of the recipients.
Scholz
D
D
Abteilung Zentrales Nierentransplantierten-Dispensaire der Urologischen Klinik.
Blank
W
W
Bärwolf
C
C
Ditscherlein
G
G
Christenfeld
R
R
Hüller
H
H
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage* / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007074:Immunoglobulin G / Q000032:analysis; D016030:Kidney Transplantation / Q000276:immunology*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000517:prevention & control; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects
D003524:Cyclosporins; D007074:Immunoglobulin G; D011239:Prednisolone; D003404:Creatinine; D001379:Azathioprine
Ergebnisse der Konversion von konventioneller immunsuppressiver Therapie auf Cyclosporin A bei Komplikationen nach Nierentransplantation.