[The morphofunctional characteristics of lymphoma NK/LY cells treated with concanavalin A and Vibrio cholerae neuraminidase].
Mouse NK/LY lymphoma cells were modified by Con A or Vibrio cholerae neuraminidase (VCN). Severe damage of the modified cells was not revealed by either supravital staining or light microscopy. Ultrastructural signs of metabolic lowering in the Con-A-treated cells were determined. Some increase in electrophoretic mobility of Con-A-modified cells was found, along with its decrease in VCN-modified cells. The decrease in the pool of proliferating cells was determined in both the types of modification, being more evident in the Con-A-modified material. A marked tumorigenic decrease of Con-A-modified cells was fixed.
Bratus'
G G
GG
Naumenko
O I
OI
Nastenko
E P
EP
Novichenko
N L
NL
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D004586:Electrophoresis; D008223:Lymphoma / Q000503:physiopathology / Q000648:ultrastructure*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009439:Neuraminidase / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D014734:Vibrio cholerae / Q000201:enzymology*
D003208:Concanavalin A; D009439:Neuraminidase
Morfofunktsional'ne osobennosti kletok limfomy NK/LY, obrabotannykh konkanavalinom A i neĭraminidazoĭ kholernykh vibrionov.