The effects of charcoal and sorbitol (alone and in combination) on plasma theophylline concentrations after a sustained-release formulation.
1. The effects of charcoal and sorbitol, alone and in combination, were investigated in eight healthy female volunteers who received 600 mg slow-release theophylline (two 300 mg capsules). 2. The area under the plasma concentration time curve to 24 h (AUC0-24) after theophylline alone was significantly greater than after both the charcoal and charcoal plus sorbitol phase. 3. Charcoal and charcoal with sorbitol also significantly reduced the maximum plasma theophylline concentration (Tmax) and time to maximum concentration (Cmax). 4. Sorbitol significantly increased Cmax and shortened Tmax. 5. Although sorbitol did not reduce the adsorptive efficacy of charcoal, its use alone may be deleterious in poisoning with sustained-release theophylline products.
al-Shareef
A H
AH
Welsh National Poisons Unit, Llandough Hospital, UK.
Buss
D C
DC
Allen
E M
EM
Routledge
P A
PA
D000328:Adult; D000628:Aminophylline / Q000378:metabolism; D001682:Biological Availability; D002606:Charcoal / Q000378:metabolism / Q000494:pharmacology*; D002792:Cholestyramine Resin / Q000378:metabolism; D003084:Colestipol / Q000378:metabolism; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D013012:Sorbitol / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D013997:Time Factors
D003692:Delayed-Action Preparations; D002792:Cholestyramine Resin; D002606:Charcoal; D000628:Aminophylline; D013012:Sorbitol; D013806:Theophylline; D003084:Colestipol