[Model of occlusion-reperfusion arrhythmias of the transplanted heart in rats].
Rats with heterotopically transplanted heart were used for modeling of occlusion-reperfusion arrhythmias. Heart transplantation was carried out by performing the anastomoses between the recipient carotid artery and jugular vein and innominate artery and pulmonary artery of the transplant respectively. The reversible ischemia of myocardium was achieved through temporal occlusion of recipient carotid artery supplying transplanted heart. The model is characterised by total denervation of the heart, the absence of pump function, total nature of myocardial ischemia during occlusion of supplying artery, high reproducibility of arrhythmias and the opportunity of repeated use of the animals.
Akchurin
R S
RS
Khalatov
V Iu
VIu
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004562:Electrocardiography; D016027:Heart Transplantation; D008297:Male; D015425:Myocardial Reperfusion; D051381:Rats; D011919:Rats, Inbred Strains; D016042:Transplantation, Heterotopic
Model' okkliuzionno-reperfuzionnykh aritmiĭ peresazhennogo serdtsa u krys.