title: [Interaction of cholestyramine and chloroquine].
abstract: The plasma levels of chloroquine after an oral intake of 10 mg/kg were measured in 5 children, with or without simultaneous intake of cholestyramine. Plasma chloroquine levels measured 6 hours after intake were significantly lower in case of simultaneous administration of cholestyramine, in spite of important individual changes. These data suggest a decrease in chloroquine bioavailability in the presence of cholestyramine. However, the methodology used does not allow to assert it.
authors.affiliation: Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon.
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
authors.forename: F
authors.initials: F
authors.lastname: Verdier
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
authors.forename: M
authors.initials: M
authors.lastname: Nardou
mesh_terms: D000293:Adolescent; D001682:Biological Availability; D002648:Child; D002738:Chloroquine / Q000493:pharmacokinetics*; D002792:Cholestyramine Resin / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans
chemical_list: D002792:Cholestyramine Resin; D002738:Chloroquine
vernacular_title: Interaction entre cholestyramine et chloroquine.