Proton relaxation enhancement in experimental brain tumors--in vivo NMR study of manganese(III)TPPS in rat brain gliomas.
The effect of manganese(III)tetraphenylporphine sulfonate (MnTPPS) on the relaxation enhancement of NMR images (MRI) was studied in experimental brain tumors in rats. Brains were inoculated with the glioma cell line F98 12 to 19 days before the NMR experiment, and the effect of MnTPPS (0.25 mmol/kg body weight) was investigated 2 and 4 days after intraperitoneal injection. After MnTPPS addition tumors could be clearly distinguished by the brightness from the surrounding brain whereas they were barely visible without contrast enhancement. At SE time of 25 msec and TR time of 3500 msec the ratio of magnetization values of tumor versus normal grey matter increased from 0.98 +/- 0.08 to 1.24 +/- 0.09 (means +/- SD). When TR was shortened to 1100 msec contrast enhancement further increased to 1.77 +/- 0.25. These results demonstrate for the first time that MnTPPS is an efficient agent for contrast enhancement of brain tumors.
Bockhorst
K
K
Max-Planck-Institut für neurologische Forschung, Abteilung für experimentelle Neurologie, Cologne, FRG.
Höhn-Berlage
M
M
Kocher
M
M
Hossmann
K A
KA
D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D005910:Glioma / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese; D011166:Porphyrins; D051381:Rats
D003287:Contrast Media; D011166:Porphyrins; C016136:tetraphenylporphine sulfonate; D008345:Manganese