[Kinetic analysis of contraction-relaxation process in smooth muscles].
A method is proposed for analysing kinetic curves of the smooth muscle contraction--relaxation approved on smooth muscle preparations of ureter and taenia coli. A notion of the velocity coefficient is introduced. It is the parameter which gives a quantitative characteristics of changes in the dynamics of muscle contraction and relaxation under the effect of factors modifying the contractile response. In order to illustrate the application of this parameter studies were carried out of the effect of sodium-free medium, monensin, and of temperature decrease on the contractile activity of the smooth muscle tissue of the ureter. The method can be useful while investigating the regularities of electro- and pharmacomechanical conjunction in the smooth muscles, as well as during pharmacological screening of compounds--regulators of calcium homeostasis in myocytes and their contractile activity.
Kosterin
S A
SA
Burdyga
F V
FV
D000818:Animals; D003106:Colon / Q000502:physiology; D006168:Guinea Pigs; D007700:Kinetics; D008954:Models, Biological; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009130:Muscle, Smooth / Q000502:physiology*; D014513:Ureter / Q000502:physiology
Kineticheskiĭ analiz protsessa sokrashcheniia-rasslableniia gladkikh myshts.