title: Influence of electrical stimulation of the hypothalamus on ovarian steroidogenesis in hypophysectomized and adrenalectomized rats.
abstract: The effects of electrical stimulation of the lateral hypothalamic area (LHA), periventricular arcuate nucleus (ARC) and ventromedial hypothalamic nucleus (VMH) on the rates of 14C transfer from 14C-1 acetate into ovarian steroids in ovarian slices of hypophysectomized and adrenalectomized (H-A) rats were investigated. The 14C transfer rates into estrogen and 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OH-P) were decreased by LHA stimulation. The stimulation of the ARC and VMH increased the rates of 14C transfer into estrogen, progesterone and 20 alpha-OH-P. From these results, it might be suggested that these hypothalamic structures were involved in the regulation of ovarian steroidogenesis without participation of the pituitary and adrenal.
authors.affiliation: First Department of Physiology, Kochi Medical School, Nankoku, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Kaba
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Takeshima
authors.forename: N
authors.initials: N
authors.lastname: Edashige
authors.forename: K
authors.initials: K
authors.lastname: Seto
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
mesh_terms: D004092:20-alpha-Dihydroprogesterone / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology; D004558:Electric Stimulation; D004967:Estrogens / Q000096:biosynthesis*; D005260:Female; D007016:Hypophysectomy; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D010053:Ovary / Q000378:metabolism*; D010902:Pituitary Gland / Q000502:physiology*; D011374:Progesterone / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
chemical_list: D004967:Estrogens; D004092:20-alpha-Dihydroprogesterone; D011374:Progesterone