[Immunoglobulin and T-cell receptor gene rearrangements in patients with autoimmune diseases].
Immunoglobulin-(Ig-) and T-cell-receptor-(TcR-)gene rearrangements were investigated in peripheral blood lymphocytes (PBL) of patients with various autoimmune disorders. In patients with SLE there was no predominant Ig- or TcR-gene rearrangement. This was also true in patients with a long disease duration and with excessive hypergammaglobulinemia. These results lead us to suggest that B cells are activated polyclonally in these patients. In those cases, where predominantly rearranged Ig- or TcR-genes were found, the autoimmune disorder was associated with a low-grade non-Hodgkin lymphoma (NHL). This coherence of B-cell malignancy and autoimmunity was only found in patients with cryoglobulinemia (KG), cold agglutinin disease (KA), and hemolytic anemia (AIHA).
Hauke
G
G
Medizinische Universitätsklinik Freiburg, Abteilung für Rheumatologie und Klinische Immunologie.
Rüde
B
B
Hollmann
A
A
Lang
B
B
Peter
H H
HH
D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications / Q000235:genetics* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D003449:Cryoglobulinemia / Q000150:complications / Q000235:genetics / Q000276:immunology; D005260:Female; D015321:Gene Rearrangement; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000235:genetics / Q000276:immunology; D012859:Sjogren's Syndrome / Q000235:genetics / Q000276:immunology
D011948:Receptors, Antigen, T-Cell
Immunglobulin- und T-Zellrezeptor-Genrearrangements bei Patienten mit Autoimmunkrankheiten.