title: The structure of tautomycin, a dialkylmaleic anhydride antibiotic.
abstract: The chemical structure of tautomycin (C41H66O13) was determined by chemical degradation, spectroscopic analysis and 2D INADEQUATE of tautomycin labeled with [1,2-13C]acetate. Tautomycin exists in methanol-buffer solution (1% diethylamine-formic acid, pH 7.3) as an equilibrium mixture of a 2,3-dialkylmaleic anhydride and its dicarboxylic acid in a ratio of approximately 5:4.
authors.affiliation: Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
authors.forename: X C
authors.initials: XC
authors.lastname: Cheng
authors.forename: M
authors.initials: M
authors.lastname: Ubukata
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D000107:Acetylation; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004952:Esters; D005285:Fermentation; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008745:Methylation; D015394:Molecular Structure; D011714:Pyrans; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds
chemical_list: D000935:Antifungal Agents; D004952:Esters; D011714:Pyrans; D013141:Spiro Compounds; C053079:tautomycin