[Results of intracerebral inoculation of the cerebrospinal fluid of patients with Parkinson disease in experimental animals].
Intracerebral inoculation of parkinsonian's cerebrospinal fluid were carried out in 720 mice, under strict observation during 48 weeks. The inoculations led to a mortality rate of 157 mice (21.8%), being 31% (76) in the first, 17% (41) in the second, and 16% (40) after the third one. High mortality rates occurred, most prevalent in the first inoculation and during the first 7 weeks. Dendrite tumefaction and disintegration as well as nerve cell swelling were the ultrastructural changes observed in the brain of mice.
De Mattos
J P
JP
Instituto de Neurologia Deolindo Couto (INDC) da Universidade Federal do Rio de Janeiro.
Andrade
C de M
Cde M
Da Silva
A G
AG
Alencar
A
A
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D006801:Humans; D051379:Mice; D008854:Microscopy, Electron; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000401:mortality
Resultados das inoculações intracerebrais de líquido cefalorraquiano de parkinsonianos em animais de experimentações.