[An experimental study of the basic properties of drug microspheres and target treatment of rats with liver tumor].
This experimental hepatic artery embolization with Camptothecin (CPT) albumin microspheres was performed in normal rats and rats with liver tumor. The basic properties of the CPT albumin microspheres and the effects of target treatment on rats with liver tumor were studied. The results showed that the concentration of the drug released into hepatic vein was almost stable for over 3 hours after hepatic arterial infusion of CPT albumin microspheres, the partial and complete recovery of hepatic artery inflow occurred within 50-70 days after embolization. Pathological examination revealed many irreversible damages of the liver, and the tumor vessels and stains disappeared after hepatic arterial embolization, some of the tumor were decreased in size and had complete necrosis. Therefore, CPT albumin microspheres are peripheral biodegradable embolizatic substances with the property of slowly drug-releasing. It can exert the effect of chemoembolization in treating the hepatic malignant tumor, alleviating the toxic reaction of CPT and increasing the patient's tolerance to CPT.
Wu
X J
XJ
Second Military Medical College, Shanghai.
D000818:Animals; D002166:Camptothecin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D007261:Infusions, Intra-Arterial; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains
D003692:Delayed-Action Preparations; D002166:Camptothecin