[Sedative-hypnotic effect of caulis Polygoni multiflori decoction].
The sedative-hypnotic effect of Caulis Polygoni multiflori decoction (CPMD) was studied by the rolling cylinder method in mice and by the somnopolygraphic recording method in rats. The result from the rolling method in mice showed that CPMD (9g/kg) did have synergic action with the subthreshold hypnotic dose of sodium pentobarbital (20mg/kg). The result from the somnopolygraphic recording experiment showed that the immediate hypnotic effect of an effective dose of CPMD (20g/kg) was basically similar to that of diazepam (5mg/kg) used under the same experimental condition, chiefly an increase in the duration of slow wave sleep phase (SWS) and a decrease in the duration of paradoxical sleep phase (PS). By the end of a three-day session in dose of twice a day the hypnotic effect appeared more prominent and the reduction of SWS latency became significant.
Yang
J
J
Xu
J
J
Zhou
L
L
Huang
L
L
Yang
S
S
Xiong
T
T
Dong
L
L
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D003975:Diazepam