Evaluation of ibuprofen dimethyl aminoethanol octyl bromide and related active metabolites in biological samples.
AF 150 is ibuprofen dimethyl aminoethanol octyl bromide, endowed with antibacterial and antiinflammatory activities. An indirect HPLC analytical method for AF 150 with UV detection, to be used for pharmacokinetic studies, has been validated in terms of linearity, reproducibility, specificity and sensitivity. Using this method the bioavailability of AF 150 and its active metabolite ibuprofen was investigated following parenteral administration and topical application.
Marzo
A
A
Real srl, Villaguardia, Como, Italy.
Reiner
A
A
Monti
N
N
Ripamonti
M
M
Lucarelli
C
C
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
C065129:ibuprofen dimethyl aminoethanol octyl; D007052:Ibuprofen