[Hemodynamic and microcirculatory changes in the liver in experimental acute pancreatitis of dogs].
To investigate the hemodynamic changes of the liver in acute pancreatitis the microcirculation of the liver, portal venous flow, hepatic artery blood flow, cardiac index were measured in 15 dogs with acute pancreatitis induced by autologous bile and trypsin injection into the main pancreatic duct during the experimental period for 5 hrs. The effect of protease inhibitor (PATM) in a dose of 3 mg/kg/kg/hr on those hemodynamic changes was investigated in another series of acute pancreatitis in dogs. In acute pancreatitis hepatic microcirculation decreased to 26 +/- 15 ml/min/100g at 5 hrs after onset of pancreatitis, portal venous flow and hepatic artery flow decreased to 86 +/- 16 ml/min and 66 +/- 30 ml/min at 5 hrs, respectively. The administration of PATM maintained the portal blood flow during the first 2 hrs and showed a trend of decreasing to 219 +/- 93 ml/min at 5 hrs. The hepatic microcirculation showed 77 +/- 25 ml/min/100g and 72 +/- 14 ml/min/100g at 1 and 2 hrs respectively and then decreased to 47 +/- 21 ml/min/100g at 5 hrs. We concluded hemodynamic and microcirculatory changes of the liver in acute pancreatitis was disturbed due to the decreased portal and hepatic artery flow, however, the administration of PATM has an effect of improvement of liver microcirculation.
Nishiwaki
H
H
First Department of Surgery, Osaka City University Medical School, Japan.
Hiura
A
A
Sin-so
H A
HA
Koh
I
I
Satake
K
K
Umeyama
K
K
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008102:Liver Circulation / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D010195:Pancreatitis / Q000473:pathology / Q000503:physiopathology*; D011480:Protease Inhibitors / Q000494:pharmacology
D011480:Protease Inhibitors