The renal excretion of pethidine administered postoperatively to male dogs.
The urinary excretion of pethidine and its major metabolite, norpethidine, was investigated in four male dogs given pethidine as a postoperative analgesic. The urinary excretion of pethidine in the first 4 h after drug administration was low at 1.9% of the administered dose. The percentage of the drug excreted as norpethidine was also low at 3.7% but there was a great deal of individual variation. Urinary excretion, therefore, appears to be a minor route in the clearance of pethidine in the dog.
Kalthum
W
W
Department of Veterinary Surgery, University of Bristol, Langford.
Waterman
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AE
D000818:Animals; D004285:Dogs / Q000652:urine*; D008614:Meperidine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine*; D011184:Postoperative Period
D008614:Meperidine; C002752:normeperidine