title: Localization of P-31 MR signal with use of superparamagnetic iron oxide particles.
abstract: Volume localization of magnetic resonance signals was achieved by using the regional susceptibility differences produced by superparamagnetic iron oxide particles. In vitro experiments demonstrated a direct linear relationship between the concentration of particulate iron and phosphorus-31 chemical shift or line broadening. In vivo experiments indicated that an intravenous dose of 5-10 mg of iron per kilogram of body weight suppressed P-31 signal from normal liver in healthy rats. In rats with hepatic implants of mammary adenocarcinoma, superparamagnetic iron oxide particles suppressed detectable P-31 or hydrogen-1 signal arising from healthy liver tissue, but not that from tumor. Signal due to surface tissues, which affect surface-coil spectra, could be selectively suppressed with a film-based application of particles to the abdominal wall. Thus, P-31 spectra from simulated or actual lesions could be selectively detected after chemically suppressing signals from neighboring or surrounding tissue.
authors.affiliation: Department of Radiology, University of California School of Medicine, San Francisco 94143-0628.
authors.forename: B L
authors.initials: BL
authors.lastname: Engelstad
authors.forename: D L
authors.initials: DL
authors.lastname: White
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
authors.forename: D D
authors.initials: DD
authors.lastname: Stark
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D052203:Ferrosoferric Oxide; D066298:In Vitro Techniques; D007501:Iron / Q000008:administration & dosage; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010087:Oxides; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010087:Oxides; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate; D007501:Iron; D052203:Ferrosoferric Oxide