Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes.
The analgesic and antiinflammatory activities of some N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes 3 a-l were studied. The compounds were prepared very conveniently by fusion of phenyl salicylate 2 and diaminoalkanes 1 a-l. The pharmacological activities were influenced by the number of carbon atoms in the polimethylenic chain. Some derivatives were more effective and less gastrolesive than salicylamide.
Daidone
G
G
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Parlermo.
Raffa
D
D
Maggio
B
B
Plescia
S
S
Matera
M
M
Caruso
A
A
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D062385:Hydroxybenzoates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003959:Diamines; D062385:Hydroxybenzoates