Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences.
Theoretical search and selection criteria for putative fusion peptides of enveloped viruses are proposed. Arenavirus fusion peptides are predicted on the basis of computer-assisted analysis of amino acid sequences of arenavirus envelope proteins and elements of their secondary and tertiary structure. Accordingly, two regions of GP2 surface protein from 5 viruses of Arenaviridae family have been detected with properties typical of fusion peptides of other enveloped viruses. One region, named peptide IV, located at the N-terminus of the GP2 protein, is followed by the other region or peptide V, more likely candidate for the arenavirus fusion peptide.
Glushakova
S E
SE
Department of Special Pathogens, Byelorussian Research Institute of Epidemiology and Microbiology, Minsk, U.S.S.R.
Lukashevich
I S
IS
Baratova
L A
LA
D000595:Amino Acid Sequence; D001116:Arenaviridae; D007836:Lassa virus; D008562:Membrane Glycoproteins / Q000648:ultrastructure; D008969:Molecular Sequence Data; D010455:Peptides; D011487:Protein Conformation; D014759:Viral Envelope Proteins / Q000648:ultrastructure; D014760:Viral Fusion Proteins / Q000648:ultrastructure
D008562:Membrane Glycoproteins; D010455:Peptides; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins