title: [Morbidity of surgical treatment for advanced cancer of the breast after irradiation].
abstract: The authors reviewed the medical files of 100 patients with locally advanced breast cancer (stage III), treated in the department of surgery of the Institut Jules-Bordet between 1974 and 1988. All patients received preoperative radiotherapy (average total dose of 45 Grays). This preoperative irradiation was associated with chemotherapy in 74% of patients. All patients subsequently underwent surgery and a modified radical mastectomy was performed in 92% of cases. Our data analysis reveals an incidence of 25% of local wound infections, 34% of delayed wound healing, 63% of seroma formation and 22% of lymphoedema of the upper limb. The local postoperative morbidity appears to be increased in patients preoperatively irradiated. This indicates that preoperative chemotherapy may be preferable in these patients to minimise the local postoperative morbidity and its impact on the quality of life.
authors.affiliation: Service de Chirurgie, Institut Jules-Bordet, Centre anticancéreux de l'Université Libre de Bruxelles, Belgique.
authors.forename: C
authors.initials: C
authors.lastname: Guenier
authors.forename: M
authors.initials: M
authors.lastname: Coibion
authors.forename: A
authors.initials: A
authors.lastname: Badr el Din
authors.forename: J M
authors.initials: JM
authors.lastname: Nogaret
authors.forename: I
authors.initials: I
authors.lastname: Lorent
authors.forename: E
authors.initials: E
authors.lastname: Toueni
authors.forename: P
authors.initials: P
authors.lastname: Vanhoute
authors.forename: W
authors.initials: W
authors.lastname: Mattheiem
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged; D011183:Postoperative Complications; D011300:Preoperative Care; D011878:Radiotherapy / Q000009:adverse effects*; D014945:Wound Healing
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Morbidité du traitement chirurgical du cancer due sein avancé après irradiation.