Kaposi's sarcoma in human T-cell leukemia virus type I-associated adult T-cell leukemia.
Kaposi's sarcoma (KS) developed in a patient with human T-cell leukemia virus type I (HTLV-I)-associated adult T-cell leukemia who was treated with a short-term course of monoclonal antibody immunotherapy. The presentation was transient and temporally related to the underlying clinical course. The association of KS in an HTLV-I infected, but not human immunodeficiency virus (HIV)-infected, individual should alert investigators to the occurrence of KS in retroviral-associated diseases other than acquired immunodeficiency disease syndrome. Recognition of the similarities and differences between HTLV-I and HIV infections may provide insights concerning the angiopathogenesis of KS.
Greenberg
S J
SJ
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Jaffe
E S
ES
Ehrlich
G D
GD
Korman
N J
NJ
Poiesz
B J
BJ
Waldmann
T A
TA
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D006679:HIV Seropositivity; D015486:HTLV-I Antigens / Q000032:analysis; D006801:Humans; D007167:Immunotherapy; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D012882:Skin Tests
D000911:Antibodies, Monoclonal; D015486:HTLV-I Antigens