Immunoscintigraphy in laryngeal and pharyngeal carcinomas using indium-111 labelled monoclonal antibody.
Localization of primary tumors, metastases or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was determined with radioimmunoscintigraphy using monoclonal radiolabelled anti-CEA-antibody. In 12 of the 13 cases, immunohistochemical stainings were positive for CEA. Correct radioimmunoscintigraphic localization was obtained in 15 of the 19 surgically verified tumor sites. There were two positive scintigraphic findings which could not be verified during one year follow-up. The CEA serum concentrations were with one exception normal in all patients, showing that the serum CEA level does not predict the possible benefit from anti-CEA radioimmunoscintigraphy.
Kairemo
K J
KJ
Division of Nuclear Medicine, Helsinki University Central Hospital, Finland.
Hopsu
E V
EV
D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007275:Injections, Intravenous; D007822:Laryngeal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007205:Indium Radioisotopes