The effect of serum from patients of chronic renal failure on colony forming units (CFU-S) in mice.
Repopulating ability of mouse bone marrow stem cells, treated with pre-dialysis, post-dialysis and control sera was assessed by colony forming units (CFU-S). Significant lower colony counts were observed in pre-dialysis group as compared to control group. There was an improvement in the colony counts when the cells were treated with post-dialysis sera. The study suggests the presence of inhibitor/s of CFU-S in the uraemic sera which is/are partially removed by haemodialysis.
Srivastava
A
A
Department of Pathology, University College of Medical Sciences, New Delhi.
Agarwal
S
S
Malhotra
K K
KK
Sood
S K
SK
D000328:Adult; D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D051379:Mice; D008875:Middle Aged; D006435:Renal Dialysis; D013234:Stem Cells / Q000276:immunology*; D014511:Uremia / Q000276:immunology*