Specific anti-digoxin Fab fragments: an available antidote for proscillaridin and scilliroside poisoning?
The purpose of this study was to evaluate the capacity of specific anti-digoxin Fab fragments to bind to and neutralize scilliroside and proscillaridin in acute poisoning. Apparent affinity constants were determined with values of 2.6 10(8)M-1 for scilliroside and 3.8 10(7)M-1 for proscillaridin. These results are in accordance with a possible in-vivo neutralization of these toxins.
Sabouraud
A
A
INSERM U26, Hôpital Fernand Widal 200, Paris, France.
Urtizberea
M
M
Cano
N
N
Garnier
R
R
Scherrmann
J M
JM
D000915:Antibody Affinity; D000931:Antidotes; D002018:Bufanolides / Q000506:poisoning; D004077:Digoxin / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D011442:Proscillaridin / Q000506:poisoning; D012378:Rodenticides / Q000506:poisoning; D014316:Tritium
D000931:Antidotes; D002018:Bufanolides; D007140:Immunoglobulin Fab Fragments; D012378:Rodenticides; D014316:Tritium; C022879:scilliroside; D004077:Digoxin; D011442:Proscillaridin