[The effect of modified sham-feeding on gastrin-stimulated gastric secretion in patient with duodenal ulcer].
Patients with duodenal ulcer were classified into responders to H2-receptor antagonist and non-responders in whom duodenal ulcer did not heal within three months with the antagonist. In these patients and healthy controls, modified sham-feeding (MSF) test was performed to elucidate the pathophysiological differences between these groups, especially vagal activity of acid output. After tetragastrin 4 micrograms/kg/hr infusion for one hour, MSF was superimposed to the infusion (G + MSF). The acid output of non-responders (8 cases) and controls (8 cases) significantly increased in G + MSF. On the other hand, the acid output of responders (6 cases) significantly decreased. The acid output of non-responders in G + MSF was also significantly higher than that of controls. The results suggest that vagal activity of non-responders is higher than responders, and that there is disturbance of inhibitory mechanism in vagal system.
Sakakibara
T
T
First Department of Medicine, Hamamatsu University School of Medicine.
Kaneko
E
E
Kumagai
J
J
Ito
G
G
Ooi
S
S
D000328:Adult; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000503:physiopathology; D004435:Eating; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins; D006801:Humans; D008297:Male; D013758:Tetragastrin; D014630:Vagus Nerve / Q000503:physiopathology
D005755:Gastrins; D013758:Tetragastrin