[Penetration of antibiotics in alveolar macrophages compared by in vitro and in vivo data in man].
Optimal therapy of infections caused by intracellular organisms requires an active antibiotic prone to intracellular penetration. This phenomenon has been studied on alveolar macrophages as well in vitro as in vivo for most groups of antibiotics. The comparison of data shows that the values obtained by incubation are not predictive of what happens in situ. These results must be taken in account for the choice of an antibiotic in pulmonary infections as well as its spectrum, pharmacokinetic, and possible side effects.
Harf
R
R
Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Panteix
G
G
Leclercq
M
M
Perrin-Fayolle
M
M
D000900:Anti-Bacterial Agents / Q000145:classification / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000378:metabolism
D000900:Anti-Bacterial Agents
Pénétration des antibiotiques dans les macrophages alvéolaires comparaison des données in vitro et in vivo chez l'homme.