Nasal secretion specific IgE in rhinitis patients.
Forty-five subjects with rhinitis of suspected allergic origin underwent immune and allergy testing including skin-tests and immuno-enzymatic assay of serum and nasal secretion specific IgE (RAST). Nasal secretion was collected using a cotton tampon inserted in both middle meati. A statistical analysis comparing the results of skin-tests and serum RAST was performed: the results obtained with these two techniques were very homogeneous (86.7% accuracy). An overall concordance (82.2%) was also observed by comparing skin-tests and nasal secretion RAST. Finally, the results of serum and nasal secretion RAST were compared: in this case totally superimposed data were reported (overall accuracy: 93.3%). In all cases the comparison between RAST classes in serum and nasal secretion was carried out: the difference between the semiquantitative evaluation of reaginic concentration classes using these two methods is not statistically significant (chi-square test). This technique of nasal secretion collection is simple and with no risk involved.
Patriarca
G
G
Servizio di Allergologia, Università Cattolica del Sacro Cuore, Rome, Italy.
di Rienzo
V
V
Schiavino
D
D
Nucera
E
E
Romano
A
A
Pellegrino
S
S
Milani
A
A
Fais
G
G
D000293:Adolescent; D000328:Adult; D001826:Body Fluids / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology*; D011852:Radioallergosorbent Test; D012220:Rhinitis / Q000097:blood / Q000276:immunology*; D012882:Skin Tests; D013048:Specimen Handling / Q000379:methods
D007073:Immunoglobulin E