title: Failure of ADCC to predict HIV-associated disease progression or outcome in a haemophiliac cohort.
abstract: Antibody-dependent cell-mediated cytotoxicity (ADCC) has been described in a number of virus infections and occurs in HIV infection. In spite of numerous studies on the ability of HIV-positive sera to mediate ADCC, it remains unclear whether ADCC has any functional significance. Here we examine serial serum samples from a cohort of haemophilia patients who became infected from a common source in 1984, and show that there is no significant difference in ADCC values between those who remained asymptomatic and those who progressed to disease. This study does not compare effector cell function and clinical status and does not exclude activity against different target cell lineages in vivo.
authors.affiliation: Retrovirus Research Group, MRC Clinical Research Centre, Harrow, UK.
authors.forename: A
authors.initials: A
authors.lastname: Dalgleish
authors.forename: A
authors.initials: A
authors.lastname: Sinclair
authors.forename: M
authors.initials: M
authors.lastname: Steel
authors.forename: D
authors.initials: D
authors.lastname: Beatson
authors.forename: C
authors.initials: C
authors.lastname: Ludlam
authors.forename: J
authors.initials: J
authors.lastname: Habeshaw
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D015483:HIV Antibodies / Q000276:immunology; D015488:HIV Antigens / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D013997:Time Factors
chemical_list: D015483:HIV Antibodies; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41