In vitro cytotoxicity of polyindolenine alkaloids on rat hepatoma cell lines. Structure activity relationships.
New groups of polyindolenine alkaloids have been isolated from new species of the tribe Psychotriae (Rubiaceae). The cyto-inhibitory effects of these compounds on tumoral cell lines have been thoroughly investigated and thus allow the statement of relationships between some original structural patterns and the observed biological effects.
Adjibadé
Y
Y
Université Louis Pasteur, Faculté de Pharmacie, Laboratoire de Pharmacognosie, Illkirch, France.
Saad
H
H
Kuballa
B
B
Beck
J P
JP
Sévenet
T
T
Cabalion
P
P
Anton
R
R
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D007536:Isomerism; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D008970:Molecular Weight; D011108:Polymers; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D011108:Polymers