title: Morphometric definition and grading of gastric intestinal metaplasia.
abstract: Type I and type III intestinal metaplasia in gastric mucosa have been examined using morphometric methods. Tissue (volume per cent gland, lumen, epithelium, goblet cell vacuoles) and nuclear parameters (area, with related standard deviation, and form factors) were used as indicators of gland crowding, nuclear-cytoplasmic ratio, nuclear atypia, and pleomorphism. In type III intestinal metaplasia, there is significantly (i) greater nuclear pleomorphism, (ii) a higher nuclear-cytoplasmic ratio, and (iii) smaller and less numerous goblet cell vacuoles in both the upper and the lower parts of the crypts. These two parameters have significantly higher values in the lower than in the upper part of individual crypts. No cell population with large pleomorphic nuclei characterized type III metaplasia, though there was more variation in nuclear size.
authors.affiliation: Institute of Pathological Anatomy and Histopathology, University of Siena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tosi
authors.forename: M I
authors.initials: MI
authors.lastname: Filipe
authors.forename: J P
authors.initials: JP
authors.lastname: Baak
authors.forename: P
authors.initials: P
authors.lastname: Luzi
authors.forename: R
authors.initials: R
authors.lastname: Santopietro
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: V
authors.initials: V
authors.lastname: Sforza
authors.forename: T
authors.initials: T
authors.lastname: Megha
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005088:Exocrine Glands / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D009077:Mucins / Q000032:analysis; D009093:Mucus / Q000032:analysis; D052116:Sialomucins; D013270:Stomach / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D009077:Mucins; D052116:Sialomucins; C012564:sulfomucin