[Antiaggregatory and anticoagulant effects of oligoamines. 12. Alkyl- and arylalkyl- derivatives of putrescine, spermidine and spermine].
Eleven lipophilic derivatives of the title biogenic amines and 28 structurally related triamines and tetramines have been synthesized. Twenty-three of them inhibited the platelet aggregation induced by collagen at an IC50 between 8 mumol/L and 30 mumol/L. Five compounds prolonged the one stage thromboplastin time (Quick) by 7s or more at 100 mumol/L. The antiplatelet and anticoagulant effect do not run parallel. The relationship between the effects observed and the chemical structure of the oligoamines has been elucidated.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin.
Puchert
E
E
Leissring
S
S
D000925:Anticoagulants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011700:Putrescine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D013096:Spermine; D013095:Spermidine; D011700:Putrescine
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 12. Mitt. Alkyl- und Arylalkylderivate von Putrescin, Spermidin und Spermin.