Prostaglandin production in chronic progressive multiple sclerosis.
Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E2 (PGE2) and thromboxane B2 (TxB2) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB2 release were noted between the three groups.
Aberg
J A
JA
Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Demers
L M
LM
Romano
P J
PJ
Tenser
R B
RB
D002851:Chromatography, High Pressure Liquid; D003165:Complement System Proteins / Q000008:administration & dosage; D015232:Dinoprostone / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology; D011453:Prostaglandins / Q000097:blood*; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000097:blood
D011453:Prostaglandins; D013929:Thromboxane B2; D003165:Complement System Proteins; D015232:Dinoprostone