title: [The use of immunoenzyme analysis in studying the etiologic structure of influenza morbidity in 1985-1988].
abstract: In the periods of epidemic increases in the incidence of influenza in 1985-1988, approximately 600 patients with clinical diagnoses of ARVI and influenza were examined for the presence of viral antigen in nasopharyngeal washings by solid-phase enzyme-immunoassay and for antibody rises in paired blood sera. The use of modified SPEIA and original test sera for influenza type A and B viruses in rapid diagnosis of influenza made it possible to decode the etiology of the epidemic situations in 1985-1988. Influenza A and B virus antigens were detected in a high portion of the examined nasopharyngeal washings. The analysis of the distribution of positive results in the detection of viral antigen in the clinical specimens and in influenza serodiagnosis demonstrated a high correlation of the results (93.9%). The etiological pattern of influenza in recent years is characterized by simultaneous circulation in the human population of influenza A (H1N1, H3N2) and B viruses, as reflected by detection of mixed infections in 1-3% of the cases.
authors.forename: E I
authors.initials: EI
authors.lastname: Isaeva
authors.forename: Z I
authors.initials: ZI
authors.lastname: Rovnova
authors.forename: T G
authors.initials: TG
authors.lastname: Poliakova
authors.forename: V M
authors.initials: VM
authors.lastname: Stakhanova
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006385:Hemagglutination Inhibition Tests; D006525:Hepatitis, Viral, Human / Q000382:microbiology; D006801:Humans; D009980:Influenza A virus / Q000276:immunology* / Q000302:isolation & purification; D009981:Influenza B virus / Q000276:immunology* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D009031:Moscow / Q000453:epidemiology; D009305:Nasopharynx / Q000382:microbiology; D012621:Seasons
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Primenenie immunofermentnogo analiza dlia izucheniia étiologicheskoĭ struktury zabolevaemosti grippom v 1985--1988 gg.