[Effects of radiation on the human renal cell carcinoma transplantable to the nude mice].
Effects of irradiation were studied using human renal cell carcinoma (AM-RC-3) implanted subcutaneously in nude mice. Tumors were irradiated locally with 60Co gamma-ray as a single dose of 5, 10, 15 and 20 Gy, then the tumor volume was measured periodically. Efficacy of irradiation was determined using Battelle Columbus Standard. The data obtained are as follows: 1) Tumor growth in every irradiated groups was delayed significantly (p less than 0.01) as compared with control group. 2) There was a significant difference in tumor growth between 10 and 15 Gy group, but no significant difference among any other groups. 3) The ratio of RV (relative mean tumor volume) of irradiated to that of unirradiated group (T RV/C RV) obtained from the tumor growth curve was 42% or less in all groups except in the 5 Gy group. A dose more than 15 Gy was particularly effective and the tumor mass was reduced to a T RV/C RV of 5.3% and 5.2% by 15 and 20 Gy, respectively.
Hishikawa-Itoh
Y
Y
Department of Radiology, Aichi Medical University.
Miyata
N
N
Yamada
Y
Y
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000532:radiotherapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage