title: Photochemical one-pot synthesis of vinblastine and vincristine.
abstract: The naturally occurring cytostatic dimer alkaloids vinblastine 1 and vincristine 2 were photochemically synthesized in slightly acidic aqueous solution from the monomer alkaloids catharanthine 3 and vindoline 4. Multi-centre reactions should obviously be involved and some of the principal photochemistry-associated phenomena here discussed are quite likely to be characteristic even to the biosynthetic reactions yielding vinblastine 1 and vincristine 2 in the cells of Catharanthus roseus.
authors.affiliation: Helsinki University of Technology, Department of Chemistry, Espoo, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Pennanen
authors.forename: A
authors.initials: A
authors.lastname: Huhtikangas
mesh_terms: D007202:Indicators and Reagents; D010777:Photochemistry; D014747:Vinblastine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D014748:Vinca Alkaloids; D014750:Vincristine / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D014748:Vinca Alkaloids; C009667:vindoline; D014750:Vincristine; D014747:Vinblastine; C017836:catharanthine