title: Protective efficacy of the Takeda acellular pertussis vaccine combined with diphtheria and tetanus toxoids following household exposure of Japanese children.
abstract: The clinical efficacy of an acellular pertussis vaccine containing lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and the 69-kd outer membrane protein, combined with diphtheria and tetanus toxoids and adsorbed onto an aluminum salt, was assessed in a household contact study. The occurrence of pertussis 7 to 30 days following home exposure among 62 previously vaccinated children was compared with that among 62 unvaccinated children similarly exposed. Classic whooping cough was diagnosed in 43 unimmunized children, and 1 vaccinated child experienced a 5-week illness that was probably pertussis (efficacy, 98%; 95% confidence interval, 84% to 99%). A few children in each group incurred respiratory illnesses that may have represented mild, atypical pertussis; including these as probable pertussis, vaccine efficacy was 81% (95% confidence interval, 64% to 90%). It is concluded that prior immunization with this four-component pertussis vaccine combined with diphtheria and tetanus toxoids is highly efficacious in preventing pertussis.
authors.affiliation: Department of Epidemiology, Case Western Reserve University, Cleveland, Ohio.
authors.forename: E A
authors.initials: EA
authors.lastname: Mortimer
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: J D
authors.initials: JD
authors.lastname: Cherry
authors.forename: H
authors.initials: H
authors.lastname: Kuno-Sakai
authors.forename: M G
authors.initials: MG
authors.lastname: Stout
authors.forename: C L
authors.initials: CL
authors.lastname: Dekker
authors.forename: R
authors.initials: R
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: J V
authors.initials: JV
authors.lastname: Scott
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D015982:Bias; D002648:Child; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000494:pharmacology / Q000592:standards*; D006801:Humans; D007223:Infant; D007564:Japan; D014917:Whooping Cough / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine