The biological characteristics of a water soluble porphyrin in rat lymph nodes.
The biological characteristics of a radiolabeled metalloporphyrin, 5,10,15,20-tetrakis(4-carboxyphenyl)-porphinato [67Cu]copper (II) [( 67Cu]TCPP), in rat lymph nodes, surrounding muscle, fat, and blood were determined. Lymphatic tissue localized greater amounts of [67Cu]TCPP than did surrounding muscle and fat. Inflamed lymph nodes localized greater amounts of [67Cu]TCPP than did noninflamed lymph nodes. Time course studies suggest that the uptake of [67Cu]TCPP in noninflamed and in inflamed lymph nodes may involve different biological processes. The affinity of [67Cu]TCPP for inflamed lymph nodes may be influenced by the degree of inflammation. If further studies confirm these results, [67Cu]TCPP may be useful as a potential radiopharmaceutical for imaging inflamed lymph nodes.
Cole
D A
DA
Medical Radioisotopes Research Program, Los Alamos National Laboratory, NM 87545.
Mercer-Smith
J A
JA
Schreyer
S A
SA
Norman
J K
JK
Lavallee
D K
DK
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003301:Copper Radioisotopes; D008198:Lymph Nodes / Q000378:metabolism*; D008199:Lymphadenitis / Q000378:metabolism; D008297:Male; D008665:Metalloporphyrins / Q000097:blood / Q000493:pharmacokinetics*; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
D003301:Copper Radioisotopes; D008665:Metalloporphyrins; C063213:5,10,15,20-tetrakis(4-carboxyphenyl)porphinatocopper(II)