title: [High-dose inhaled beta-2 sympathomimetics in severe bronchial asthma].
abstract: We made the observations that in patients with severe bronchial asthma, the inhalative dose of beta-2 sympathomimetics that was required for optimal bronchial dilation revealed a large inter-individual scatter. In 21 patients, the inhalation of a maximum of 10 metered doses of salbutamol at intervals of five minutes each, led to a mean (SD) increase in the FEV 1.0 from 1.3 (0.6) 1 to 1.8 (0.7) 1. The maximum increase in the FEV 1.0 was achieved in 10 patients following the inhalation of 1 to 3 metered doses, and in 11 patients after 4 to 10 such doses. The individual requirement for inhaleable beta-2 agonists should therefore be taken into account when planning treatment.
authors.affiliation: Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie.
authors.forename: A
authors.initials: A
authors.lastname: Meyer
authors.forename: P
authors.initials: P
authors.lastname: Jacobsen
authors.forename: H
authors.initials: H
authors.lastname: Magnussen
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage
chemical_list: D005938:Glucocorticoids; D013806:Theophylline; D000420:Albuterol
vernacular_title: Hochdosierte inhalative Beta-2 Sympathomimetika bei schwerem Asthma bronchiale.