title: Delayed biliary-to-bowel transit in cholescintigraphy after cholecystokinin treatment.
abstract: The authors assessed the influence of cholecystokinin (CCK), administered before cholescintigraphy, on the biliary-to-bowel transit time (BBTT) of technetium-99m disofenin. Fourteen healthy volunteers underwent two separate cholescintigraphic studies with and without CCK treatment. BBTT was less than 1 hour in all 14 studies of subjects not treated with CCK. In 14 subjects treated with CCK, there was no tracer activity in the bowel up to 2 hours in seven (50%) (P = .006). Eighty-three cholescintigrams obtained in patients with suspected acute cholecystitis were also retrospectively analyzed. In 53 of 83 patients in whom the gallbladder was visualized within 1 hour, significantly delayed BBTT was found in 14 of 29 (48%) who received CCK, compared with the BBTT in one of 24 patients (4%) who did not receive CCK (P less than .001). In the 30 patients in whom the gallbladder was never visualized (n = 28) or was visualized after 1 hour (n = 2), BBTT was less than 30 minutes, regardless of whether patients were treated with CCK. Results show that CCK treatment causes significantly delayed BBTT in many cases, and this finding should not be interpreted as abnormal.
authors.affiliation: Andre Meyer Department of Physics and Nuclear Medicine, Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: C K
authors.initials: CK
authors.lastname: Kim
authors.forename: C J
authors.initials: CJ
authors.lastname: Palestro
authors.forename: R W
authors.initials: RW
authors.lastname: Solomon
authors.forename: D S
authors.initials: DS
authors.lastname: Molinari
authors.forename: S O
authors.initials: SO
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Goldsmith
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002764:Cholecystitis / Q000000981:diagnostic imaging; D002766:Cholecystokinin / Q000494:pharmacology*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007098:Imino Acids / Q000493:pharmacokinetics; D007422:Intestines / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D019785:Technetium Tc 99m Disofenin; D013997:Time Factors
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D002766:Cholecystokinin; D019785:Technetium Tc 99m Disofenin