title: Synthesis and pharmacological activity of 6H-thiazolo [3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives, a new heterocyclic ring system.
abstract: In the outline of the investigations concerning the analgesic and antiinflammatory activity of new fused heterocyclic compounds containing the pyrimidine ring, a series of 6H-thiazolo[3',2': 1,2]-5-oxopyrimido[5,4-b]indole derivatives was synthesized. Pharmacological results are reported and discussed.
authors.affiliation: Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: S
authors.initials: S
authors.lastname: Guccione
authors.forename: E
authors.initials: E
authors.lastname: Bousquet
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: M G
authors.initials: MG
authors.lastname: Leone
authors.forename: G
authors.initials: G
authors.lastname: Attaguile
authors.forename: M A
authors.initials: MA
authors.lastname: Roxas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005122:Exudates and Transudates / Q000378:metabolism; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D011743:Pyrimidines; D013844:Thiazoles; D002351:Carrageenan