title: Xanthogranulomatous cholecystitis. Histopathological study and classification.
abstract: Xanthogranulomatous cholecystitis (XC) is a chronic inflammatory lesion of the gallbladder histologically characterized by the presence of varying amounts of foamy histiocytes in the inflammatory infiltrate. In this study a review of 63 cases selected from 1207 surgically removed gallbladder is presented; the percentage found (5.2%) is slightly higher than that of previous reports showing that XC is less uncommon than generally believed. A detailed microscopic study is performed: the authors observed according to the histological features particularly the different patterns of distribution of the inflammatory infiltrate and postulate the existence of three subtypes of XC: multinodular, focal and diffuse XC. Finally, the main etiopathogenetic hypotheses are briefly discussed.
authors.affiliation: Istituto di Anatomia e Istologia Patologica dell' Università di Palermo, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Franco
authors.forename: F
authors.initials: F
authors.lastname: Aragona
authors.forename: G
authors.initials: G
authors.lastname: Genova
authors.forename: A M
authors.initials: AM
authors.lastname: Florena
authors.forename: M
authors.initials: M
authors.lastname: Stella
authors.forename: G
authors.initials: G
authors.lastname: Campesi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002764:Cholecystitis / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005705:Gallbladder Diseases / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D006099:Granuloma / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014973:Xanthomatosis / Q000145:classification / Q000453:epidemiology / Q000473:pathology