Transfer of diclofenac sodium across excised guinea pig skin on high-frequency pulse iontophoresis. II. Factors affecting steady-state transport rate.
Some of the factors affecting the steady-state transport rate of diclofenac sodium across excised guinea-pig skin during high-frequency pulse iontophoresis were examined. The same mathematical expression was employed for enhancement ratio as a function of applied voltage as the one derived for direct-current iontophoresis. The effective voltage drop across the skin was only 1.1% of the applied voltage. The steady-state flux value increased with increase of the donor concentration.
Koizumi
T
T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Kakemi
M
M
Katayama
K
K
Inada
H
H
Sudeji
K
K
Kawasaki
M
M
D000818:Animals; D004008:Diclofenac / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007478:Iontophoresis; D008297:Male; D012869:Skin Absorption
D004008:Diclofenac