[A comparative study of the effect of nimodipine and flunarizine on the intact and ischemic myocardium].
In the experiments on anesthetized cats and dogs it was shown that calcium antagonists nimodipine and flunarisine possessing the predominant action on the cerebral vessels exert a significant effect on the blood supply and the activity of the cardiac muscle. Administration of the drugs causes bradycardia, increases the total coronary blood flow. Nimodipine enhances the contractile function of the myocardium, flunarisine fails to change it. Under ischemia of the cardiac muscle the drugs increase the blood supply of only the intact zones of the left ventricle without influencing positively the blood supply of the ischemic focus itself.
Kazanova
G V
GV
Kirsanova
G Iu
GIu
Tsorin
I B
IB
Chichkanov
G G
GG
D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005444:Flunarizine / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009553:Nimodipine / Q000494:pharmacology* / Q000627:therapeutic use
D009553:Nimodipine; D005444:Flunarizine
Sravnitel'noe izuchenie vliianiia nimodipina i flunarizina na intaktnyĭ i ishemizirovannyĭ miokard.