The histopathology of rat lung following exposure to zinc oxide/hexachloroethane smoke or installation with zinc chloride followed by treatment with 70% oxygen.
The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation of zinc chloride produced similar effects that included pulmonary edema, alveolitis and, at a later stage, some fibrosis. After zinc chloride instillation, the pathological changes largely spared the periphery of the lung, while following smoke inhalation they were more diffuse. Subsequent oxygen administration had little effect on the development or progression of the pathological changes.
Brown
R F
RF
Pathology Section, Ministry of Defence, Chemical Defence Establishment, Salisbury, Wiltshire, UK.
Marrs
T C
TC
Rice
P
P
Masek
L C
LC
D000280:Administration, Inhalation; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D006582:Hexachlorophene / Q000008:administration & dosage / Q000633:toxicity*; D007322:Instillation, Drug; D008171:Lung Diseases / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D010102:Oxygen Inhalation Therapy; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012906:Smoke / Q000009:adverse effects; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*; D017967:Zinc Compounds; D015034:Zinc Oxide / Q000008:administration & dosage / Q000633:toxicity*
D002712:Chlorides; D012906:Smoke; D017967:Zinc Compounds; C016837:zinc chloride; D006582:Hexachlorophene; D015032:Zinc; D015034:Zinc Oxide