title: Ocular effects of two different prostaglandin F2 alpha esters. A doublemasked cross-over study on normotensive eyes.
abstract: Ocular hypotensive effects and side effects of two different topically applied prostaglandin (PG) esters were evaluated in a double masked study in 12 healthy males. Three doses of 15-propionat-PGF2 alpha-isopropylester (15-prop-PGF2 alpha-IE), two doses of PGF2 alpha-isopropylester (PGF2 alpha-IE), and placebo were compared. At equipotent doses 15-prop-PGF2 alpha-IE caused similar ocular side effects as PGF2 alpha-IE. It is concluded that both PGF2 alpha-IE and 15-prop-PGF2 alpha-IE reduce the IOP in normal eyes, but the use of a diester such as 15-prop-PGF2 alpha-IE does not provide a better separation between effect on IOP and side effects than PGF2 alpha-IE.
authors.affiliation: Department of Ophthalmology, University Hospital, Umeå, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Villumsen
authors.forename: A
authors.initials: A
authors.lastname: Alm
mesh_terms: D000287:Administration, Topical; D000328:Adult; D015237:Dinoprost / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D015814:Ocular Hypotension / Q000139:chemically induced
chemical_list: C065542:15-propionat-prostaglandin F2alpha-isopropyl ester; C041158:prostaglandin F2 isopropyl ester; D015237:Dinoprost