Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma.
The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.
Bongioannini
G
G
II Clinica Otorinolaringoiatrica, Università degli Studi di Torino, Italia.
Vercellino
M
M
Rugiu
M G
MG
Ferreri
A
A
Succo
G
G
Cortesina
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007108:Immune Tolerance; D007432:Intraoperative Period; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D011184:Postoperative Period; D065227:Transfusion Reaction