Fructose-1,6-diphosphate counteracts ethanol-stimulated calcium uptake in isolated BHK cells.
Ethanol increases the uptake of 45Ca by isolated baby hamster kidney (BHK) cells in vitro. The effect is dependent on ethanol and 45Ca++ concentration and on the incubation time. Fructose-1,6-diphosphate (FDP) added at different concentration during the pre-incubation exerts a protective effect through a membrane-stabilizing action which is consistent with its in vivo anti-alcohol activity documented in previous studies.
Rizzoli
V
V
Department of Biological Chemistry, University of Padova, Italy.
Battilana
G
G
Galzigna
L
L
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D000431:Ethanol / Q000494:pharmacology*; D005635:Fructosediphosphates / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000494:pharmacology*; D013997:Time Factors
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D000431:Ethanol; C029063:fructose-1,6-diphosphate; D002118:Calcium