[Biological age and longitudinal study of aging].
We assessed the biological aging status by multiple regression analysis of clinical parameters. Estimated ages of external appearance, physiological function, physical strength and general biological status were calculated. The aging grade was defined as the percent estimated age to chronological age. The aging grade was lower in the managers, and in nonsmokers. It was lower in subjects who drank a small amount of alcohol than in those who drank a large amount of alcohol or those who did not drink alcohol. We also studied the longitudinal changes of 27 clinical parameters. Physical, hematological and blood biochemical data were annually recorded for a 10-year period. Age-time matrix was made for each parameter and was analyzed in terms of aging, cohort and time, by utilizing [1] longitudinal, [2] cross-sectional and [3] time series approaches. The parameters that were considered to be affected by aging were right grip strength (reduced), and sedimentation rate (increased).
Tateishi
T
T
Department of Geriatrics, Nagoya University School of Medicine.
Shimokata
H
H
Kuzuya
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis