title: Single and combination effects of administering salinomycin and aflatoxin to broiler chicks.
abstract: A factorial design (2 by 3) was used to evaluate the interaction between aflatoxin (0, 2.5, and 5 mg per kg) and salinomycin [0, 60 g per ton (909 kg)]. There were four replicates of 10 chicks per treatment. The chicks were maintained in batteries from 0 to 3 wk of age, with feed and water available for ad libitum intake. Aflatoxin at both levels (2.5 and 5 mg per kg) with and without salinomycin decreased body weight. The efficiency of feed utilization was affected only at the 5 mg per kg level of aflatoxin. Feeding 5 mg per kg of aflatoxin alone decreased the hemoglobin level. The inclusion of salinomycin (60 g per ton) in the diet with 2.5 or 5 mg per kg of aflatoxin initiated no significant change in body weight or feed efficiency. No significant interaction was observed between aflatoxin and salinomycin on any of the parameters measured.
authors.affiliation: Cooperative Agricultural Research Center, Prairie View A&M University, Texas 77446.
authors.forename: S A
authors.initials: SA
authors.lastname: Pearson
authors.forename: V G
authors.initials: VG
authors.lastname: Stanley
authors.forename: A H
authors.initials: AH
authors.lastname: Reine
authors.forename: W E
authors.initials: WE
authors.lastname: Huff
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000097:blood / Q000254:growth & development*; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology*; D000095662:Polyether Polyketides
chemical_list: D000348:Aflatoxins; D003049:Coccidiostats; D006454:Hemoglobins; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides