Cholesterol oxidation on fluorocarbon emulsion surface leads to the formation of 7-peroxycholesterol.
Formation of biologically active oxidized derivatives of cholesterol as a result of its oxidation on the surface of fluorocarbon emulsions was studied. A single product of cholesterol oxidation, 7-peroxycholesterol, was found. It was shown that 7-peroxycholesterol and its derivative 7-keto-cholesterol inhibit the rosette formation between human T-lymphocytes and sheep erythrocytes. These substances exert a strong cytostatic action on the growth of procaryotic and eucaryotic cell cultures. Thus, oxidative modification of blood plasma components on the surface of fluorocarbon emulsion particles with the formation of highly active compounds must be taken into account when using the fluorocarbon emulsions in medicine.
Beriozov
A T
AT
Institute of Physiochemical Medicine, Ministry of Public Health of the RSFSR, Moscow.
Ivanov
A S
AS
Ivkov
V G
VG
Obraztsov
V V
VV
Khalilov
E M
EM
Archakov
A I
AI
D000128:Acholeplasma laidlawii / Q000187:drug effects; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002784:Cholesterol; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D004655:Emulsions; D005466:Fluorocarbons; D066298:In Vitro Techniques; D007653:Ketocholesterols / Q000494:pharmacology; D008054:Lipid Peroxides; D008081:Liposomes; D010084:Oxidation-Reduction; D010100:Oxygen
D004655:Emulsions; D005466:Fluorocarbons; D007653:Ketocholesterols; D008054:Lipid Peroxides; D008081:Liposomes; D002784:Cholesterol; C003001:7-ketocholesterol; D010100:Oxygen