Aggression by ovariectomized female rats: combined testosterone/estrogen implants support the development of hormone-dependent aggression.
Female hooded rats were ovariectomized and implanted with a single estrogen-filled and a single testosterone-filled Silastic tube. Control animals were ovariectomized and implanted with empty tubes. The implants produced an estrogen concentration of 30 pg/ml and a testosterone concentration of 0.25 ng/ml, levels close to those found in intact females. Two weeks following surgery, all animals were housed in individual cages, placed on a 23-hr food-deprivation schedule, and adapted to a liquid food. They were then housed in hormone-implant/empty-implant pairs and given a series of 3 restricted-access competition tests and 3 free-access competition tests (1/day). The animals were then paired with new partners and given a second series of restricted-access and free-access competition tests. Ovariectomized females with hormone implants were more successful at maintaining access to the liquid food and more aggressive than their competitors without hormone replacement. The aggression was used to maintain access to food during free-access as well as restricted-access competition. Following the competition tests, animals with hormone implants were significantly more aggressive toward an unfamiliar conspecific than were their cagemates with empty implants. The level of success and aggression by females with testosterone + estrogen implants appears greater than that which occurs with either hormone alone and comparable to that observed in intact females.
Albert
D J
DJ
Psychology Department, University of British Columbia, Vancouver, Canada.
Jonik
R H
RH
Walsh
M L
ML
D000374:Aggression / Q000502:physiology*; D000378:Agonistic Behavior / Q000502:physiology; D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D001143:Arousal / Q000502:physiology*; D003163:Competitive Behavior / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D010052:Ovariectomy; D051381:Rats; D012931:Social Environment; D013739:Testosterone / Q000502:physiology*
D004967:Estrogens; D013739:Testosterone