CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.
A new polyether antibiotic CP-84,657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Treponema hyodysenteriae.
Dirlam
J P
JP
Central Research, Pfizer Inc., Groton, CT 06340.
Belton
A M
AM
Bordner
J
J
Cullen
W P
WP
Huang
L H
LH
Kojima
Y
Y
Maeda
H
H
Nishida
H
H
Nishiyama
S
S
Oscarson
J R
JR
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D003461:Crystallography; D004539:Eimeria / Q000187:drug effects*; D005285:Fermentation; D005663:Furans / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011714:Pyrans / Q000494:pharmacology; D000095662:Polyether Polyketides
D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D005663:Furans; D011714:Pyrans; C065219:CP 84657; C010327:salinomycin; D000095662:Polyether Polyketides