[Lipid peroxidation and state of antioxidant system in patients with systemic lupus erythematosus].
Lipid peroxidation (LP) and antioxidant system (AS) have been investigated in 30 patients suffering from systemic lupus erythematosus (SLE). LP was assessed by plasma levels of intermediate (dienic conjugates) and end (malonic dialdehyde) LP products, AS by concentration of alpha-tocopherol and free fatty acids indicating the intensity of phospholipase hydrolysis. Shifts in AS and LP correlated with clinical SLE appearance. The paper discusses causes which may underlie the observed abnormalities and validity of antioxidant SLE therapy.
Agisheva
K N
KN
Salikhov
I G
IG
D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D005230:Fatty Acids, Nonesterified; D014810:Vitamin E; D008315:Malondialdehyde
Perekisnoe okislenie lipidov i sostoianie antioksidantnoĭ sistemy u bol'nykh sistemnoĭ krasnoĭ volchankoĭ.