Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes, III: Evaluation of the mammary tumor inhibiting properties.
Diastereomeric diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone-dependent MXT-M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to the R,R/S,S configurated diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) salts the corresponding R,S configurated compounds are also markedly active on the hormone-independent MXT-Ovex mammary carcinoma of the B6D2F1 mouse.
Reile
H
H
Institut für Pharmazie, Universität Regensburg, FRG.
Spruss
T
T
Müller
R
R
Gust
R
R
Bernhardt
G
G
Schönenberger
H
H
Engel
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D008815:Mice, Inbred Strains; D009566:Nitrates / Q000138:chemical synthesis / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis*; D013464:Sulfuric Acids / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005029:Ethylenediamines; D009566:Nitrates; D009944:Organoplatinum Compounds; D013464:Sulfuric Acids