Variation of corticosteroid-induced inhibition of collagen synthesis at equivalent anti-inflammatory doses.
At equivalent anti-inflammatory doses of corticosteroids, granuloma growth is not linearly related to the inhibition of granuloma collagen synthesis. However, the inhibition of granuloma collagen synthesis is linearly related to the inhibition of skin collagen synthesis. Therefore the decrease of collagen synthesis by corticosteroids is not related to anti-inflammatory activity but is related to the specific corticosteroid used.
Cutroneo
K R
KR
Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405.
DiPetrillo
T A
TA
Cutroneo
K R
KR
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D004195:Disease Models, Animal; D006099:Granuloma / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*; D013256:Steroids
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D013256:Steroids; D003094:Collagen