title: Multiple graft harvestings from deep partial-thickness scald wounds healed under the influence of weak direct current.
abstract: The time required for wound healing, contraction, and hypertrophic scarring often limit the use of deep partial-thickness burn wounds as donor sites for split-thickness grafts. We have examined the effects of weak direct current and silver nylon dressings on the healing of partial-thickness scald burns, split-thickness grafts taken from these wounds when healed, and the resulting donor sites in a guinea pig model. Dorsal scald wounds treated with weak direct current reepithealized by 12 days postinjury. Split-thickness grafts taken from healed scald wounds showed more rapid revascularization with direct current treatment than did control grafts. Grafts and donor sites treated with direct current showed more rapid reepithelialization, decreased contraction, improved hair survival, and decreased dermal fibrosis when compared to controls not treated with direct current. Only donor wounds treated with weak direct current were reusable as donor sites.
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234-5012.
authors.forename: C S
authors.initials: CS
authors.lastname: Chu
authors.forename: A T
authors.initials: AT
authors.lastname: McManus
authors.forename: A D
authors.initials: AD
authors.lastname: Mason
authors.forename: C V
authors.initials: CV
authors.lastname: Okerberg
authors.forename: B A
authors.initials: BA
authors.lastname: Pruitt
mesh_terms: D000818:Animals; D001458:Bandages; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D004599:Electric Stimulation Therapy / Q000379:methods*; D004848:Epithelium / Q000254:growth & development; D006168:Guinea Pigs; D008297:Male; D009757:Nylons; D012834:Silver; D012867:Skin / Q000098:blood supply / Q000166:cytology; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014945:Wound Healing
chemical_list: D009757:Nylons; D012834:Silver