title: [Gas transfer in nonspecific inhalation provocation].
abstract: In 37 patients with clinically suspected non-specific bronchial hyperreactivity, a comparative study was performed prior to and following bronchial challenge with histamine employing the following parameters: flow-volume curve, whole-body plethysmography, single-breath spirometry, capillary blood gas analysis. Four types of reaction can be distinguished: isolated bronchial reaction, isolated gas transfer disturbance, dual reaction, no reaction. A Correlation of the induced gas transfer disturbance was found only for the flow data reflecting small airways dysfunction (Vmax 25%), but not for the basic lung function parameters. The transfer factor and transfer coefficient are insensitive and, on average, show only small, non-directed changes.
authors.affiliation: Lungenklinik Heckeshorn, Krankenhaus Zehlendorf, Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Schultebraucks
authors.forename: W
authors.initials: W
authors.lastname: Frank
authors.forename: R
authors.initials: R
authors.lastname: Loddenkemper
mesh_terms: D000328:Adult; D000368:Aged; D001985:Bronchial Provocation Tests / Q000379:methods*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*
chemical_list: D006632:Histamine; D010100:Oxygen
vernacular_title: Untersuchungen zum Gastransfer bei der unspezifischen inhalativen Provokation.