Relative absorption of the two enantiomers of terbutaline after duodenal administration.
The absorption of the two enantiomers of terbutaline, (+)-terbutaline and (-)-terbutaline, and of the racemate, (+/-)-terbutaline, has been studied in six healthy volunteers using a newly developed intestinal perfusion technique. The area under the plasma concentration curve for the (-)-enantiomer was more than twice that for the (+)-enantiomer. The data demonstrate a clear difference in absorption efficiency between (-)- and (+)-terbutaline, but further studies are required to establish whether (-)-terbutaline influences the absorption of (+)-terbutaline.
Borgström
L
L
Explorative Clinical Research, AB Draco, Lund, Sweden.
Kennedy
B M
BM
Nilsson
B
B
Angelin
B
B
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004386:Duodenum; D006801:Humans; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D008297:Male; D010477:Perfusion; D013237:Stereoisomerism; D013726:Terbutaline / Q000493:pharmacokinetics*
D013726:Terbutaline