[Pathogenesis of varicose ulcers of the lower extremities].
The article discusses the biochemical mechanisms of skin destruction and ulcer formation in patients with varicosity of the lower limbs. Cathepsins A, B, C, and D were determined in the skin in various parts of the limb in 57 patients: in the lower third of the leg the activity of cathepsin D was increased by 183.8%, that of cathepsin B by 140.2%, and the activity of cathepsin B by 239%. On basis of the data obtained the authors conclude that cathepsins take part in skin destruction. Increased activity of cathepsin D plays the initiative role in this process. Cathepsin activity reduced after 14-16 day treatment with aescusan; D by 24.1%, B by 17.7%, and A by 15.4%. The authors link the effect of the treatment with the protective effect of the preparation on the lysosomal membranes.
Gostishchev
V K
VK
Khokhlov
A M
AM
Vorobeĭchik
T A
TA
Shimanovskaia
N P
NP
D002403:Cathepsins / Q000378:metabolism*; D004789:Enzyme Activation / Q000502:physiology; D006801:Humans; D012867:Skin / Q000201:enzymology*; D014647:Varicose Ulcer / Q000209:etiology*; D014648:Varicose Veins / Q000150:complications* / Q000201:enzymology
D002403:Cathepsins
Patogenez iazvy pri varikoznoĭ bolezni nizhnikh konechnosteĭ.