[Thymolytic effects of methandrostenolone].
It was shown, that in castrated rats dianabol (10 mg/kg of body mass daily for 7 days) inhibits the protein synthesis in thymus. The binding analysis of 3H-dianabol showed the specific binding sites in thymic cytosol, which are identical to those for androgens. Isolated thymocytes didn't bind dianabol.
Chermnykh
N S
NS
Dukhanin
A S
AS
Andreev
Iu A
IuA
Karymshakova
Ch T
ChT
D000728:Androgens / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D002369:Castration; D003600:Cytosol / Q000378:metabolism; D008297:Male; D008696:Methandrostenolone / Q000008:administration & dosage / Q000494:pharmacology*; D014176:Protein Biosynthesis; D051381:Rats; D013601:T-Lymphocytes / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000728:Androgens; D008696:Methandrostenolone
Izuchenie mekhanizmov timoliticheskogo éffekta metandrostenolona.