Invertebrate neuropeptides resembling vasotocin and some analogues: synthesis and pharmacological properties.
The solid phase synthesis of three invertebrate vasopressin-oxytocin homologs: AVP-like factor, F1(1), ([Leu2, Thr4] AVT)2 isolated from subesophageal and thoracic ganglia of Locusta migratoria3, Arg-conopressin-S4. ([Ile2, Arg4] AVT), Lys-conopressin-G4 ([Phe2, Arg4] LVT), both isolated from the venom of fish-hunting marine snails of the genus Conus and six of their analogues is reported. These analogues are: [Arg4] AVT, [Ile2] AVT, [Leu2] AVT, [Phe2, Arg4] AVT, [Arg4] LVT and [Ile2, Arg4] LVT. All peptides were tested for antidiuretic and vasopressor activities.
Kruszyński
M
M
Department of Biochemistry, Medical College of Ohio, Toledo 43699.
Manning
M
M
Wo
N C
NC
Sawyer
W H
WH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004231:Diuresis / Q000187:drug effects; D007447:Invertebrate Hormones / Q000138:chemical synthesis* / Q000494:pharmacology; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010121:Oxytocin; D051381:Rats; D014668:Vasotocin
D007447:Invertebrate Hormones; D009479:Neuropeptides; D010121:Oxytocin; D014668:Vasotocin