title: cANCA test and the detection of Wegener's disease in sclerokeratitis and uveitis.
abstract: Ocular signs and symptoms may be the initial signs of systemic or limited Wegener's granulomatosis. The diagnosis is difficult to make on ophthalmic manifestations alone, because clinical and histopathological markers are not specific enough. By means of the cANCA serum test it is possible to make the diagnosis in an early stage and to prevent more disastrous complications. The relation of cANCA titre and the clinical and histopathological findings of five patients with an acute or chronic Wegener's granulomatosis are discussed.
authors.affiliation: Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: F J
authors.initials: FJ
authors.lastname: van der Woude
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007159:Immunologic Tests; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D015423:Scleritis / Q000209:etiology*; D014605:Uveitis / Q000209:etiology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies