Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation.
Pillay
T S
TS
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, U.K.
Whittaker
J
J
Siddle
K
K
D000818:Animals; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate