Humoral immune responses in seals infected by phocine distemper virus.
Recently the isolation and characterisation of a morbillivirus which caused high mortality in common seals (Phoca vitulina) in 1988 have been reported. Because of the clinical and pathological similarity of the disease in seals to that of distemper in dogs, the name phocine distemper virus (PDV) has been proposed. There are marked differences in the virus-induced proteins of PDV compared to other morbilliviruses and the humoral immune response of moribund and dead seals to PDV was restricted to some of the internal antigens of PDV, similar to the response described earlier for canine distemper virus infection in dogs.
Rima
B K
BK
Department of Biology, Queen's University of Belfast, Northern Ireland.
Cosby
S L
SL
Duffy
N
N
Lyons
C
C
O'Loan
D
D
Kennedy
S
S
McCullough
S J
SJ
Smyth
J A
JA
McNeilly
F
F
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000276:immunology*; D010872:Caniformia; D004591:Electrophoresis, Polyacrylamide Gel; D010252:Paramyxoviridae / Q000276:immunology*; D011233:Precipitin Tests; D010253:Respirovirus Infections / Q000276:immunology / Q000662:veterinary*; D046048:Seals, Earless; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014764:Viral Proteins