Systemic absorption of sulphadiazine, silver sulphadiazine and sodium sulphadiazine through human burn wounds.
Systemic absorption of water-soluble and water-insoluble drugs through human burn wounds was compared. Serum levels of sulphadiazine were estimated after application of silver sulphadiazine (water-insoluble) cream, sulphadiazine (water-insoluble) cream and sodium sulphadiazine (water-soluble) cream. It was found that the absorption of sodium sulphadiazine was greater than that of sulphadiazine or silver sulphadiazine.
Aoyama
H
H
Department of Plastic Surgery, Aichi Medical University, Japan.
Yokoo
K
K
Fujii
K
K
D000042:Absorption; D000287:Administration, Topical; D000328:Adult; D002056:Burns / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013411:Sulfadiazine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D013411:Sulfadiazine; D012837:Silver Sulfadiazine