title: Cimetidine increases the pancreatic response to histamine.
abstract: The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2-0.8 n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic secretion was observed when histamine was administered against a constant background of H2 antagonist (cimetidine 4 mumol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors.
authors.affiliation: Department of Physiology, Faculty of Veterinary Sc., University of Extremadura, Cáceres, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pariente
authors.forename: L P
authors.initials: LP
authors.lastname: Francis
authors.forename: G M
authors.initials: GM
authors.lastname: Salido
authors.forename: J A
authors.initials: JA
authors.lastname: Madrid
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D011817:Rabbits
chemical_list: D002927:Cimetidine; D006632:Histamine