[A comparative analysis of the morphochemical changes in the neurons of the visual and sensorimotor cortices and the nucleus accumbens of rats administered tuftsin].
White rats were treated with a single administration of tetrapeptide tuftsin (Thr-Lys-Pro-Arg) in the dose 300 mcg/kg (b.w). Using interferometry, the protein content and concentration were assessed 15, 30 and 60 minutes after injection. The area of the neuron cytoplasm and nucleus were measured too. The nucleoplasmic balance and dispersion were calculated. Significant alterations in the protein contents and cellular area, nucleoplasmic balance and dispersion were detected in neurons of visual, sensomotor cortex and of n. accumbens. A possible interrelation is discussed between tuftsin action and the functional activity of neurons, between the level of their protein metabolism and establishment of emotional and motor response.
Chebotareva
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TL
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D008857:Microscopy, Interference; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009714:Nucleus Accumbens / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012686:Septal Nuclei / Q000187:drug effects*; D013997:Time Factors; D014405:Tuftsin / Q000494:pharmacology*; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D009419:Nerve Tissue Proteins; D014405:Tuftsin
Sravnitel'nyĭ analiz morfokhimicheskikh izmeneniĭ neĭronov zritel'noĭ, sensomotornoĭ kory i nucleus accumbens mozga krys pri vvedeniia taftsina.