title: The effect of feeding lovastatin and colestipol on production and cholesterol content of eggs.
abstract: The purpose of the present study was to determine whether feeding lovastatin or colestipol, or both, to laying hens would decrease the concentration of cholesterol in eggs. Forty-eight White Leghorn hens (69 wk of age) were allocated randomly to one of four groups. For 5 wk, the birds were fed: 1) a control diet; 2) diets supplemented with 35 mg of lovastatin per kg of feed; 3) 11.7 g of colestipol per kg of feed; or 4) both 35 mg of lovastatin and 11.7 g of colestipol per kg of feed. Drug feeding did not affect egg production or the concentration of cholesterol in the yolk, muscle, or liver. Lovastatin residue was found in liver samples from hens receiving lovastatin, but no lovastatin residue was found in the muscle, egg-white, or egg-yolk samples from hens on any treatment. These findings suggest that lovastatin or colestipol, or both, fed at relatively low amounts do not decrease the concentration of cholesterol in egg yolk and do not depress egg production.
authors.affiliation: Department of Animal Science, Iowa State University, Ames 50011.
authors.forename: C M
authors.initials: CM
authors.lastname: Luhman
authors.forename: B G
authors.initials: BG
authors.lastname: Miller
authors.forename: D C
authors.initials: DC
authors.lastname: Beitz
mesh_terms: D000821:Animal Feed; D000818:Animals; D002645:Chickens / Q000502:physiology*; D002784:Cholesterol / Q000032:analysis* / Q000097:blood; D003084:Colestipol / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D004032:Diet; D004347:Drug Interactions; D004350:Drug Residues / Q000032:analysis; D004531:Eggs / Q000032:analysis*; D005260:Female; D008099:Liver / Q000032:analysis; D008148:Lovastatin / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D010058:Oviposition / Q000187:drug effects; D011073:Polyamines / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D011073:Polyamines; D002784:Cholesterol; D008148:Lovastatin; D003084:Colestipol