title: Concentrations of temafloxacin in serum and bronchial mucosa.
abstract: The bronchial mucosal concentrations of temafloxacin hydrochloride were determined in specimens obtained at fibreoptic bronchoscopy and compared with simultaneous serum concentrations. The 18 patients studied were given an oral dose of 400 mg b.i.d for three days to achieve steady state levels. The mean serum concentration was 6.9 mg/l (SD 2.5 mg/l) and the mean bronchial mucosal concentration 12.2 mg/kg (SD 4 mg/kg). The mucosal levels exceeded those required to inhibit most of the common respiratory pathogens, including Streptococcus pneumoniae and Pseudomonas aeruginosa. These data support the use of temafloxacin for therapy of bronchial infections.
authors.affiliation: Department of Thoracic Medicine, Dudley Road Hospital, Birmingham, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Baldwin
authors.forename: L
authors.initials: L
authors.lastname: Wilkinson
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: J P
authors.initials: JP
authors.lastname: Ashby
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: D
authors.initials: D
authors.lastname: Honeybourne
mesh_terms: D042462:4-Quinolones; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000378:metabolism*; D001980:Bronchi / Q000378:metabolism*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D015363:Quinolones
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin