title: Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins.
abstract: Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues.
authors.affiliation: Department of Chemistry, University of Cambridge, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Horovitz
authors.forename: A R
authors.initials: AR
authors.lastname: Fersht
mesh_terms: D009154:Mutation; D010455:Peptides / Q000378:metabolism*; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D010455:Peptides; D011506:Proteins