title: Growth, nutrient retention, and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk.
abstract: Growth, nutrient retention, and metabolic response of low-birth-weight infants fed human milk provided by their mother; this milk supplemented with bovine milk protein, calcium, phosphorus, and sodium; or pasteurized term human milk with the same supplement were monitored from the time desired intake was tolerated until weight reached 2200 g. The supplement resulted in greater rates of weight gain (20.5 +/- 2.3 vs 16.4 +/- 2.2 g.kg-1.d-1) and nitrogen retention (353 +/- 76 vs 270 +/- 53 mg.kg-1.d-1), increase in plasma transthyretin (TTR) concentration (7 +/- 16 vs -3 +/- 9 mg.L-1.wk-1), a higher mean plasma albumin concentration (34 +/- 3 vs 32 +/- 4 g/L), and a higher plasma TTR concentration at discharge (100 +/- 22 vs 75 +/- 24 mg/L). All these variables correlated significantly with total nitrogen intake, suggesting that the differences are attributable to the protein content of the supplement. The supplement also resulted in greater rates of calcium and phosphorus accretion but the plasma alkaline phosphatase activity of the supplemented vs the unsupplemented groups did not differ.
authors.affiliation: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032.
authors.forename: S
authors.initials: S
authors.lastname: Kashyap
authors.forename: K F
authors.initials: KF
authors.lastname: Schulze
authors.forename: M
authors.initials: M
authors.lastname: Forsyth
authors.forename: R B
authors.initials: RB
authors.lastname: Dell
authors.forename: R
authors.initials: R
authors.lastname: Ramakrishnan
authors.forename: W C
authors.initials: WC
authors.lastname: Heird
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000378:metabolism; D002712:Chlorides / Q000008:administration & dosage / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D004734:Energy Metabolism; D006801:Humans; D007225:Infant Food; D007230:Infant, Low Birth Weight / Q000254:growth & development* / Q000378:metabolism; D007231:Infant, Newborn; D008895:Milk, Human; D009584:Nitrogen / Q000008:administration & dosage / Q000378:metabolism; D010758:Phosphorus / Q000008:administration & dosage / Q000378:metabolism; D011228:Prealbumin / Q000032:analysis; D011897:Random Allocation; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000378:metabolism; D015430:Weight Gain
chemical_list: D000596:Amino Acids; D001798:Blood Proteins; D002136:Calcium, Dietary; D002712:Chlorides; D004044:Dietary Proteins; D011228:Prealbumin; D012982:Sodium, Dietary; D010758:Phosphorus; D000469:Alkaline Phosphatase; D009584:Nitrogen