title: Reductions in overshoot during aspirin use.
abstract: The overshoot effect was measured before, during, and after the administration of a moderate dose of aspirin. Prior to the drug, detectability of the 6-ms, 3550-Hz signal was 5-11 dB worse when presented 2 ms after the onset of the 200-ms wideband masking noise than when presented 190 ms after masker onset. Following 4 days of aspirin use, detectability in the long-delay condition was unchanged from the predrug value, but (for four of the five subjects) detectability in the short-delay condition was improved by about 4-8 dB. Thus the overshoot effect was markedly reduced by aspirin because the drug partially counteracted the normally poor detectability for signals presented soon after masker onset. This paradoxical improvement in detectability was accompanied by an aspirin-induced loss in detectability of 5-16 dB for a 200-ms sample of that same signal presented in the quiet. Similar paradoxical effects have previously been obtained by inducing a temporary hearing loss with exposure to intense sound. It is presumed that the same basic mechanisms underlie the parallel outcomes. The so-called cochlear amplifier is discussed in this regard, and also the possibility that the known differences in those primary auditory fibers having high and low spontaneous rates may be involved. A supplementary experiment demonstrated that shifting audibility with either a wideband or a narrow-band background noise does not affect the overshoot effect in the same way as does aspirin or exposure to intense sound, further suggesting that the cochlear amplifier must be altered in order for overshoot to be diminished.
authors.affiliation: Department of Psychology, University of Texas, Austin 78712.
authors.forename: D
authors.initials: D
authors.lastname: McFadden
authors.forename: C A
authors.initials: CA
authors.lastname: Champlin
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001306:Auditory Pathways / Q000187:drug effects / Q000502:physiology*; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010470:Perceptual Masking / Q000502:physiology*
chemical_list: D001241:Aspirin