Toxicity resulting from lithium augmentation of antidepressant treatment in elderly patients.
Lithium augmentation of antidepressant treatment is a commonly used strategy for treatment-resistant cases of depression. Two cases are described in which significant neurotoxicity developed in elderly patients despite therapeutic doses of antidepressant and lithium.
Austin
L S
LS
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29464.
Arana
G W
GW
Melvin
J A
JA
D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000139:chemically induced; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000139:chemically induced
D000928:Antidepressive Agents; D005473:Fluoxetine; D008094:Lithium; D006220:Haloperidol