Calcitonin, estradiol, and hydroxyproline as parameters in the early diagnosis of involutional osteoporosis. The importance of the "second calcitonin phenomenon".
Bone metabolism was studied in a group of 92 subjects. A greater age-related decrease in calcitonin and estradiol concentrations exists in women than in men, though this difference was not significant; it was significant, however, when the values of the three different groups of women were compared. We present what we have called the second calcitonin phenomenon, that is, a highly significant difference in women between a second basal calcitonin level and the primary admission value. In the calcium infusion test, men considered to be osteoporotic showed a deceleration in the rapid loss of reserve calcitonin deposits.
Ferrández
L
L
Department of Traumatology and Orthopedic Surgery, Hospital Clínico Universitario, Salamanca, Spain.
Martín
M
M
Fernández
M
M
D000367:Age Factors; D000368:Aged; D015519:Bone Density; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000652:urine; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis* / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
D004958:Estradiol; D002116:Calcitonin; D006909:Hydroxyproline; D002118:Calcium