[Use of calcium carbonate as an intestinal chelator of phosphorus].
Fourteen patients undergoing periodic dialysis who had been taking AL(OH)3 as an intestinal chelant of phosphorus have been examined. AL(OH)3 was replaced by CaCO3 for a period of 6 months. At the end of the study, statistically significant reductions were evidenced in alkaline phosphatase, basal serum aluminiaemia and its increase after Desferal test, while the bicarbonates (HCO3) were found to be increased. Statistically non-significant increases were observed in calcaemia, PTH, and pH. It is concluded that the replacement of AL(OH)3 with CaCO3 is effective in controlling phosphoraemia, in diminishing serum concentrations and tissue deposits of Al and in improving uraemic acidosis.
Bongiorno
P
P
U.S.L. n. 68, Asti, Servizio di Nefrologia e Dialisi.
Caligaris
F
F
Montalcini
G
G
Biamino
E
E
Imarisio
P
P
Dagna
L
L
Arnaud
A
A
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000032:analysis; D000536:Aluminum Hydroxide / Q000009:adverse effects; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis
D002614:Chelating Agents; D010758:Phosphorus; D000536:Aluminum Hydroxide; D000535:Aluminum; D002119:Calcium Carbonate
Utilizzo del calcio carbonato (CaCO3) come chelante intestinale del fosforo.