title: Polarity and velocity of sliding filaments: control of direction by actin and of speed by myosin.
abstract: Myosin filaments, which are responsible for a large repertoire of motile activities in muscle and nonmuscle cells, can translocate actin filaments both toward and away from their central bare zone. This bidirectional movement suggests that there is enough flexibility in the head portion of the tightly packed myosin molecules in the native myosin filaments to move actin filaments not only in the expected direction, but also in the direction opposite to that predicted by the regular structure of muscle--away from the center of the myosin filament.
authors.affiliation: Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: J R
authors.initials: JR
authors.lastname: Sellers
authors.forename: B
authors.initials: B
authors.lastname: Kachar
mesh_terms: D000199:Actins / Q000502:physiology*; D000818:Animals; D049872:Bivalvia; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D046911:Macromolecular Substances; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology / Q000648:ultrastructure*; D009218:Myosins / Q000502:physiology*
chemical_list: D000199:Actins; D046911:Macromolecular Substances; D009218:Myosins