title: Aggregation behaviour of blood granulocytes in patients with periodontal disease.
abstract: This behaviour was studied in 17 patients with severe marginal periodontitis and in 16 healthy controls. Aggregation induced by platelet-activating factor (PAF-acether), a potent mediator of inflammation, was significantly enhanced in the patients, whereas no significant difference was observed between patients and controls when aggregation was induced by the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP). When the patients were subdivided into categories of progressive adult periodontitis, juvenile or post-juvenile periodontitis, aggregation induced by PAF-acether was enhanced in all three subgroups. However, FMLP-induced aggregation was slightly increased only in progressive adult and post-juvenile periodontitis, but decreased in juvenile periodontitis.
authors.affiliation: Institute of Pathological Biochemistry, School of Dental Medicine, Medical Academy of Erfurt, G.D.R.
authors.forename: S
authors.initials: S
authors.lastname: Krause
authors.forename: P
authors.initials: P
authors.lastname: Brachmann
authors.forename: C
authors.initials: C
authors.lastname: Brandes
authors.forename: W
authors.initials: W
authors.lastname: Lösche
authors.forename: T
authors.initials: T
authors.lastname: Hoffmann
authors.forename: P
authors.initials: P
authors.lastname: Gängler
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood; D002449:Cell Aggregation / Q000187:drug effects; D002648:Child; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010518:Periodontitis / Q000097:blood*; D010972:Platelet Activating Factor / Q000494:pharmacology
chemical_list: D010972:Platelet Activating Factor; D009240:N-Formylmethionine Leucyl-Phenylalanine