Resection guided by antibodies (REGAJ): a diagnostic procedure during second-look operation in ovarian cancer patients.
A hand-held probe has been used to localise the 131I-labelled antibody OC125 during second-look operation (SLO) in 22 ovarian cancer patients. In six patients microscopic cancer was detected with the procedure and a further six patients with areas of increased radioactivity during SLO developed recurrent disease within 1-4 months. We suggest examining resection guided by antibodies as a possible means of removing antigen-producing cancerous tissues during surgery.
Jäger
W
W
Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, FRG.
Feistel
H
H
Paterok
E M
EM
Ronay
G
G
Tulusan
A H
AH
Wolf
F
F
Lang
N
N
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000601:surgery; D011877:Radionuclide Imaging / Q000379:methods*; D012086:Reoperation
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate