[Senescence grading system in mice].
A grading system was devised to evaluate the degree of senescence in accelerated senescence prone (SAM-P) and resistant (SAM-R) mice, using 11 items considered to be associated with senescence. The items were graded from 0 to 4. For most items, the score and incidence began to increase from 4-6 month-old, continued to increase with age in both SAM-P and SAM-R and reached similar plateau levels at 12-16 months and 24 months, respectively. In both SAM-P/1 at 8 month-old and SAM-R/2 at 12 month-old, there was an inverse correlation between the total score and duration of survival after examination. Thus, the grading system is useful for evaluation of the degree of senescence of mice.
Hosokawa
M
M
Department of Senescence Biology, Kyoto University.
D000375:Aging / Q000502:physiology*; D000818:Animals; D051379:Mice; D008817:Mice, Mutant Strains