[Long-term maintenance therapy in duodenal ulcer. Efficacy and safety].
The efficacy and safety of continuous (maintenance) treatment with ranitidine has been studied retrospectively in 388 patients with duodenal ulcer. The cumulative rate of symptomatic relapse was 16% after 5 years. Very few of the patients developed ulcer complications during maintenance treatment, with a cumulative risk of haemorrhage of 1.8% during 5 years. The patients developed no drug-related disease. We conclude that long-term, continuous treatment with ranitidine is effective in maintaining remission of duodenal ulcers, protects the patients against the risk of complications, and is safe.
Penston
J
J
Ninewells Hospital, Dundee, Scotland, U.K.
Wormsley
K G
KG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D011899:Ranitidine / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
D011899:Ranitidine
Langzeiterhaltungstherapie beim Ulcus duodeni. Wirksamkeit und Sicherheit.