title: The effects of chemotherapy on murine wound healing and orocutaneous fistula closure.
abstract: The effects of cisplatin and 5-fluorouracil on wound breaking strength and the rate of closure of an orocutaneous fistula were studied in 80 male rodents. Treatment rats received a total of 4.6 mg/kg cisplatin and 62 mg/kg 5-fluorouracil in six doses/12 days; control rats received 0.9 per cent saline. After treatment, 30 treatment and 30 control rats received a dorsal skin incision which was closed primarily. Wound breaking strength were tested at one, three and five weeks in ten rats from each group. An 8-mm orocutaneous fistula was made in the remaining ten treatment and ten control rats; the rate of closure was noted weekly. Cisplatin and 5-fluorouracil did not significantly impair wound breaking strength at one, three, or five weeks. The rate of closure of the orocutaneous fistula was not effected by cisplatin/5-fluorouracil. The chemotherapy caused severe facial cellulitis and death in four orocutaneous fistula rats. Combined chemotherapy with cisplatin and 5-fluorouracil should not interfere with planned surgical care of head and neck tumors. Concomitant antibiotic coverage, however, is advocated.
authors.affiliation: Department of Surgery, Wayne State University, Detroit, Michigan.
authors.forename: T
authors.initials: T
authors.lastname: Whittle
authors.forename: C E
authors.initials: CE
authors.lastname: Lucas
authors.forename: A M
authors.initials: AM
authors.lastname: Ledgerwood
authors.forename: A
authors.initials: A
authors.lastname: Weaver
authors.forename: M
authors.initials: M
authors.lastname: al-Sarraf
authors.forename: Z X
authors.initials: ZX
authors.lastname: Guan
authors.forename: D
authors.initials: D
authors.lastname: Grabow
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology; D005402:Fistula / Q000503:physiopathology / Q000601:surgery*; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009059:Mouth Diseases / Q000503:physiopathology / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000503:physiopathology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D002945:Cisplatin; D005472:Fluorouracil