title: Calcitonin, estradiol, and hydroxyproline as parameters in the early diagnosis of involutional osteoporosis. The importance of the "second calcitonin phenomenon".
abstract: Bone metabolism was studied in a group of 92 subjects. A greater age-related decrease in calcitonin and estradiol concentrations exists in women than in men, though this difference was not significant; it was significant, however, when the values of the three different groups of women were compared. We present what we have called the second calcitonin phenomenon, that is, a highly significant difference in women between a second basal calcitonin level and the primary admission value. In the calcium infusion test, men considered to be osteoporotic showed a deceleration in the rapid loss of reserve calcitonin deposits.
authors.affiliation: Department of Traumatology and Orthopedic Surgery, Hospital Clínico Universitario, Salamanca, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ferrández
authors.forename: M
authors.initials: M
authors.lastname: Martín
authors.forename: M
authors.initials: M
authors.lastname: Fernández
mesh_terms: D000367:Age Factors; D000368:Aged; D015519:Bone Density; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000652:urine; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis* / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
chemical_list: D004958:Estradiol; D002116:Calcitonin; D006909:Hydroxyproline; D002118:Calcium