title: Evaluation of the efficacy and safety of two formulations of pyrantel pamoate in cats.
abstract: The efficacy of paste and granule formulations of pyrantel pamoate against concurrent infections of Toxocara cati and Ancylostoma tubaeforme in cats was examined in a controlled trial. Three groups of 8 cats received either no medication (controls) or pyrantel pamoate in paste or granule formulations at a dosage of 20 mg/kg of body weight. After administration of the paste formulation, fecal egg counts of A tubaeforme and T cati were decreased by 98.6 and 96.4%, respectively, and 100% of hookworms and 93.5% of ascarids were removed from the intestine. After administration of the granule formulation, fecal egg counts of A tubaeforme and T cati were decreased by 99.4 and 78.2%, respectively, and 100% of adult hookworms and 88.9% of ascarids were removed. All reductions of egg counts and worm numbers were significant (P less than 0.01). The clinical safety of pyrantel pamoate was evaluated in 4- to 6-week-old kittens. Three groups of 10 kittens received either no medication (controls) or pyrantel pamoate in paste or granule formulations at the rate of 100 mg/kg for 3 consecutive days. Adverse effects were not observed in young kittens following administration of the high dose of pyrantel pamoate.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071.
authors.forename: C R
authors.initials: CR
authors.lastname: Reinemeyer
authors.forename: R C
authors.initials: RC
authors.lastname: DeNovo
mesh_terms: D000284:Administration, Oral; D000724:Ancylostomiasis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002626:Chemistry, Pharmaceutical; D010270:Parasite Egg Count / Q000662:veterinary; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000008:administration & dosage* / Q000627:therapeutic use; D012307:Risk Factors; D014120:Toxocariasis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D011715:Pyrantel; D011716:Pyrantel Pamoate