The effect of asanguinous cardioplegic arrest on atrial preservation using atrial ATP as a marker.
Changes in atrial adenosine triphosphate (ATP) and the presence of postoperative arrhythmias were studied in 14 patients during routine coronary artery bypass grafting to 1) attempt to evaluate atrial preservation, and 2) determine if a relationship exists between changes in ATP and the development of postoperative arrhythmias. Atrial biopsies were obtained at the time of cannulation (preischemic sample) and after the removal of the aortic crossclamp (postischemic sample). Methods of myocardial protection included systemic hypothermia (28 degrees C), periodic reinfusion of crystalloid cardioplegia into the aortic root and completed vein grafts, and iced slush in the pericardial well. Atrial temperature was monitored. Preischemic ATP was 0.412 +/- 0.32 mu mol/gm, and the postischemic value was 0.220 +/- 0.13 mu mol/gm (p less than .02). Atrial temperature routinely decreased to 13-18 degrees C after cardioplegic infusion but rose to 24 degrees C between infusions. There was no correlation between postoperative supraventricular arrhythmias (4 patients) and changes in ATP. In conclusion, routine coronary artery bypass grafting with standard methods of cardiac preservation does not appear to satisfactorily preserve atrial tissue. The clinical correlation and significance of this remains to be elucidated.
Hines
G L
GL
Department of Thoracic and Cardiovascular Surgery, Winthrop University Hospital, Mineola, N.Y.
Scheaffer
P
P
Williams
L
L
Mantell
P
P
Cheifitz
P
P
D000255:Adenosine Triphosphate / Q000032:analysis*; D001145:Arrhythmias, Cardiac / Q000201:enzymology / Q000209:etiology; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood; D006324:Heart Arrest, Induced / Q000379:methods; D006325:Heart Atria / Q000201:enzymology / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism; D013053:Spectrophotometry
D015415:Biomarkers; D000255:Adenosine Triphosphate; D003402:Creatine Kinase