[Baroreceptor reflex response to acute blood loss during induced hypotension--a comparison of sodium nitroprusside, prostaglandin E1 and trimethaphan].
This experiment was designed to evaluate the reflexive heart rate (HR) response to acute blood loss during sodium nitroprusside (SNP), prostaglandin E1 (PGE1) and trimethaphan (TM) induced-hypotension in isoflurane anesthetized dogs. Reflexive increase in HR to acute blood loss was significantly greater during PGE1 induced-hypotension than during that with SNP. TM inhibited the reflexive HR response to acute blood loss. These results suggest that PGE1 induced-hypotension provides a safer margin than that with SNP and TM when rapid bleeding occurs during anesthesia and surgery.
Taneyama
C
C
Department of Anesthesiology, University of Kansas Medical Center, Kansas City.
Goto
H
H
Benson
K T
KT
Unruh
G K
GK
Arakawa
K
K
D000527:Alprostadil; D000818:Animals; D004285:Dogs; D005292:Ferricyanides; D006339:Heart Rate / Q000502:physiology; D006470:Hemorrhage / Q000503:physiopathology*; D007023:Hypotension, Controlled; D009599:Nitroprusside; D011311:Pressoreceptors / Q000503:physiopathology*; D012018:Reflex / Q000502:physiology*; D014294:Trimethaphan
D005292:Ferricyanides; D009599:Nitroprusside; D014294:Trimethaphan; D000527:Alprostadil