[Low-grade B cell gastric lymphoma originated in mucosa-associated lymphoid tissue. Relationship of tumor cells with the marginal zone and monocytoid B lymphocytes. An immunohistochemical and ultrastructural study].
Seven cases of gastric B-cell low-grade lymphomas were characterized by morphology, immunohistology and electron microscopy. All them were immunophenotyped with a panel of monoclonal antibodies against immunoglobulins and other B-cell determinants. Histologic study of gastric B-cell low-grade lymphomas showed germinal centers of lobated shape and polyclonal nature, mainly polyclonal subepithelial plasma cell (except in one case) and neoplastic interfollicular B-cells of monoclonal character. Light-chain restriction supports the neoplastic nature of gastric lymphoma of low-grade malignancy, a distinctive tumour of extranodal B-cell origin. Interfollicular B-cells share with marginal zone cells a perifollicular localization, morphology and phenotype, suggesting a possible relation between these two cellular subtypes. In two cases, the tumour appears constituted by monocytoid B-lymphocytes (MBL), which suggests a relation of tumoral interfollicular B-cells with this subpopulation.
Piris
M A
MA
Servicio de Anatomía Patológica, Hospital Virgen de la Salud, Toledo.
Rivas
C
C
Morente
M
M
Orradre
J L
JL
Rodríguez
R
R
Cruz
M A
MA
Martínez
J L
JL
Rubio
C
C
Oliva
H
H
D000328:Adult; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D005260:Female; D005753:Gastric Mucosa; D006801:Humans; D008221:Lymphoid Tissue; D008223:Lymphoma / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000473:pathology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal
Linfoma B gástrico de bajo grado originado en tejido linfoide asociado a mucosas. Relación de las células tumorales con la zona marginal y los linfocitos B monocitoides. Estudio inmunohistoquímico y ultraestructural.