[Treatment of olfactory neuroblastoma: a report of 14 cases].
Olfactory neuroblastoma is a rare malignant tumor arising from the nasal cavity. From 1982 to 1987 fourteen cases had been treated in this hospital. The average age was 34 years with a range from 15 to 65 years, male to female ratio was 1:1. At the time of diagnosis, 3 tumors were of kadish stage A-involvement of the nasal cavity only, 5 of stage B-involvement of the nasal cavity and one or more paranasal sinuses, and six of stage C-extension beyond the nasal cavity, including the orbit, base of skull or intracranial cavity, or metastasis to cervical nodes or distant sites. All were treated with radiation therapy and 7 also by surgery. The three and five-year survival rates were 50% and 30% respectively. Seven patients died, six because of distant metastases within one year. It shows that the disease is aggressive from the beginning, and tends to metastasize early. A treatment regimen for prophylactic cervical node irradiation combining chemotherapy is proposed.
Tu
M C
MC
Tumor Hospital, Guangzhou.
D000293:Adolescent; D000328:Adult; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology / Q000532:radiotherapy*; D009832:Olfactory Nerve