Studies on the genotoxicity of endosulfan, an organochlorine insecticide, in mammalian germ cells.
The genotoxic potential of endosulfan was assessed in mouse germ cells by 2 in vivo tests: the dominant lethal and the sperm shape abnormality test. At higher doses, endosulfan induced dominant lethal mutations in one mating interval (36-42 days) post treatment. A statistically significant dose-dependent increase in sperm abnormalities was observed with endosulfan treatment. At high doses the sperm count decreased up to 39%. No change in sperm motility was observed at any dose level. On the basis of the present in vivo results, it appears that endosulfan has a damaging effect on spermatogonial cells as well as on sperm morphology.
Pandey
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N
Environmental Microbiology Section, Industrial Toxicology Research Center, Mahatma Gandhi Marg, Lucknow, India.
Gundevia
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F
Prem
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AS
Ray
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PK
D000818:Animals; D004726:Endosulfan / Q000633:toxicity*; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D009153:Mutagens; D004726:Endosulfan