The effect of different nutritional states on cell-mediated cytotoxicity.
We have studied the effect of acute short-term starvation (in 9 patients) and of prolonged caloric deprivation (in 10 patients with anorexia nervosa), on cell-mediated cytotoxicity (CMC). CMC became severely depressed after six days on a very low caloric diet (1.2 +/- 1.4 vs. 7.0 +/- 2.9 lytic units/10(6) cells; P less than 0.01). CMC was also low in our patients with anorexia nervosa compared to a matched control group (3.3 +/- 1.7 vs. 10.0 +/- 3.0 lytic units/10(6) cells; P less than 0.01) and increased in most of the patients studied (five cases) after the first 3-4 weeks of refeeding in correlation with weight gain. Dietary deprivation may lead to a significant impairment in cell-mediated cytotoxicity, which appears to be reversible after refeeding.
Vaisman
N
N
Department of Paediatrics, Kaplan Hospital, Rehovot, Israel.
Hahn
T
T
Dayan
Y
Y
Schattner
A
A
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000276:immunology*; D001835:Body Weight; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D002149:Energy Intake; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D013217:Starvation / Q000276:immunology