[An experimental study of the cardio- and hemodynamic effects of the carboxyl ionophore monensin].
The effect of ionophore monensin on the main parameters of cardio- and hemodynamics was studied in the experiments on anesthetized cats. Monensin (0.075-0.375 mg/kg) administered intravenously in the increasing doses was shown to produce the dose-dependent elevation of arterial blood pressure, the increase of myocardial contractility and the total peripheral resistance. A single administration of monensin (0.375 mg/kg) was found to exert the two-phase action on the parameters of cardio- and hemodynamics.
Gurbanov
K G
KG
Kovalev
G V
GV
Paperno
A A
AA
D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D008985:Monensin / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D008985:Monensin
Eksperimental'noe izuchenie kardio- i gemodinamicheskikh éffektov karboksil'nogo ionofora monensina.