[Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system].
Effects of a 70% methanolic extract (E-S) from the dried leaves of Epimedium sagittatum on a phagocytic activity of reticuloendothelial system were studied by the carbon clearance method in mice. The clearance-rate of carbon significantly increased 1 h after the oral administration of E-S (200 or 500 mg/kg, one time/d for 5d). E-S activated the phagocytosis of carbon by Kupffer cells in the liver. Icariin and epimedin C isolated from E-S also activated the phagocytosis. These results suggest that E-S promotes the phagocytic activity of the reticuloendothelial system in mice and has a stimulatory effect on macrophage.
Iinuma
M
M
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Tanaka
T
T
Sakakibara
N
N
Mizuno
M
M
Matsuda
H
H
Shiomoto
H
H
Kubo
M
M
D000135:Acid Phosphatase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D000135:Acid Phosphatase