title: [Pharmacokinetics of drugs in single and multiple organ failure].
abstract: Organ failure modifies the pharmacokinetics of drugs and usually requires a decrease in their dosage. A decrease in cardiac output, in protein binding and extraction ratio, hepatic and renal insufficiency, a modification in acid-base balance are the main factors regulating pharmacokinetics of drugs used in anaesthesia and intensive therapy.
authors.affiliation: Medizinische Fakultät, Universität Bonn.
authors.forename: H
authors.initials: H
authors.lastname: Schwilden
mesh_terms: D000758:Anesthesia; D002303:Cardiac Output, Low / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D009102:Multiple Organ Failure / Q000378:metabolism*; D010599:Pharmacokinetics; D011485:Protein Binding; D012151:Resuscitation; D014018:Tissue Distribution
vernacular_title: Pharmacocinétique des médicaments en cas de défaillance mono et multiviscérale.