[Effects of intracellular Na+/K+ ratio on expression of c-fos oncogene and beta-actin gene in ascitic cells of leukemia P-388 and Ehrlich tumor].
The intracellular Na+/K+ ratio was studied for its effect on expression gene beta-actin and oncogene c-fos and activity of these genes during the mitotic cycle in ascites cells of leukemia P-388 and Ehrlich tumour. It was established that gene beta-actin was activated at high and low ratios of Na+/K+, while c-fos only at high ones. The expression of these genes during the mitotic cell cycle was due to changes in the intracellular Na+/K+ ratio. The obtained data showed an important role of intracellular homeostasis of monovalent cations in regulation of gene expression during the mitotic cell cycle.
Smirnova
N V
NV
Danko
I M
IM
Kolosov
E V
EV
Kaz'min
S D
SD
D000199:Actins / Q000235:genetics*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D007941:Leukemia P388 / Q000235:genetics* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008938:Mitosis; D009857:Oncogenes; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D000199:Actins; D012964:Sodium; D011188:Potassium
Vliianie vnutrikletochnogo sootnosheniia Na+/K+ na ékspressiiu onkogena c-fos i gena beta-aktina v astsitnykh kletkakh leĭkoza P-388 i raka Erlikha.