Serological H-Y antigen and gonadal status in XYDOM sex-reversed mice.
Y chromosomes of feral mice (Mus musculus domesticus) from various localities, when introduced into the C57BL/6 laboratory strain, give rise to phenotypic females and true hermaphrodites both with the sex chromosome constellation XY. Sex-reversed animals of each type were examined macroscopically or histologically for gonadal status and H-Y antigenic activity by serological assay methods. Most XY females with histologically confirmed bilateral ovaries did not differ from XX female controls with respect to serological H-Y antigen, i.e. they were H-Y negative. The true hermaphrodites were H-Y positive, though H-Y antigenic activity was intermediate to male and female controls in the majority of cases. The findings support a relationship between the presence of serological H-Y antigen and gonadal status.
Ebensperger
C
C
Institut für Humangenetik und Anthropologie, Universität, Freiburg.
Mayerova
A
A
Wienker
T F
TF
Winking
H
H
Wolf
U
U
D000818:Animals; D012734:Disorders of Sex Development / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006182:H-Y Antigen / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae; D010053:Ovary / Q000473:pathology; D010641:Phenotype; D012732:Sex Determination Analysis; D013737:Testis / Q000473:pathology
D006182:H-Y Antigen