Effect of renal function on the bioavailability of ciprofloxacin.
The effect of renal function on the bioavailability of ciprofloxacin was studied in 21 subjects with measured creatinine clearances ranging from 0 to 8.99 liters/h per 1.73 m2. Each subject received ciprofloxacin, 200 mg intravenously and 750 mg orally, separated by at least 1 week. Serial (12 to 15) blood samples were obtained over 24 to 48 h. Concentrations in serum were assayed by high-pressure liquid chromatography. Area under the curve was calculated by the trapezoidal rule with extrapolation to infinity. Bioavailability was calculated as the ratio between the dose-normalized area under the curve of oral and intravenous administrations. The overall mean (standard deviation) bioavailability observed was 63.4% (14.6%), similar to that observed in those with normal renal function (69.0% [15.7%]). The mean bioavailability in the subgroup of subjects with renal insufficiency was 59.9% (13.3%). The observed range in bioavailability was 33.9 to 91.4%. Linear regression did not reveal a correlation between creatinine clearance and bioavailability. Renal insufficiency does not appear to affect ciprofloxacin bioavailability.
Plaisance
K I
KI
University of Maryland School of Pharmacy, Baltimore 21201.
Drusano
G L
GL
Forrest
A
A
Weir
M R
MR
Standiford
H C
HC
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D007275:Injections, Intravenous; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D002939:Ciprofloxacin