title: Gamma scintigraphic imaging of lung microvascular permeability in adult respiratory distress syndrome.
abstract: The sequence of lung microvascular permeability (LMVP) changes in early direct posttraumatic and late indirect pancreatitis-induced adult respiratory distress syndrome (ARDS) was studied and compared with that of a control group, as well as non-ARDS ICU patients. A computerized large field of view gamma camera was used to measure LMVP simultaneously over both lungs by In 113m-labeled transferrin and Tc 99m-labeled erythrocytes. The LMVP index (LMVPI) (%/h) was used to quantify LMVP in the dynamic scintigraphic measurement. In the control group the LMVPI was 2.6 +/- 2.8%/h for the right and 2.0 +/- 2.8%/h for the left lung. Similar values were found in mechanically ventilated ICU patients without ARDS (group A) on admission (right LMVPI 3.2 +/- 2.6, left LMVPI 2.6 +/- 2.7%/h) and 4 days later (right LMVPI 3.9 +/- 2.6, left LMVPI 2.3 +/- 1.8%/h). Interestingly, the initial evaluation of patients with direct early posttraumatic ARDS (lung contusion) (group B) showed significantly (p less than .01) elevated LMVP for the contused side (LMVPI 10.8 +/- 5.1%/h), but normal values for the nontraumatized lung (LMVPI 3.9 +/- 3.4%/h), whereas 4 days later the LMVP increased significantly (p less than .05) on the primarily healthy side (LMVPI 8.0 +/- 5.0%/h) while remaining elevated for the traumatized lung (LMVPI 10.9 +/- 6.0%/h).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Clinic of Anesthesiology and Intensive Care Medicine, University of Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Putensen
authors.forename: N
authors.initials: N
authors.lastname: Mutz
authors.forename: G
authors.initials: G
authors.lastname: Himmer
authors.forename: M
authors.initials: M
authors.lastname: Neumann
authors.forename: U
authors.initials: U
authors.lastname: Waibel
authors.forename: G
authors.initials: G
authors.lastname: Putz
authors.forename: B
authors.initials: B
authors.lastname: Braunsberger
authors.forename: M
authors.initials: M
authors.lastname: Oberladstätter
mesh_terms: D000328:Adult; D000818:Animals; D002199:Capillary Permeability; D003422:Critical Care; D004285:Dogs; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications; D010195:Pancreatitis / Q000150:complications; D011877:Radionuclide Imaging; D012016:Reference Values; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D013898:Thoracic Injuries / Q000150:complications