title: Effect of fluoride concentration on remineralization of carious enamel: an in vitro pH-cycling study.
abstract: An in vitro pH-cycling experiment was carried out to investigate the effect of fluoride concentration on enamel demineralization and remineralization. Artificial caries lesions were formed in an acid-buffered solution and subjected daily to a 3-hour acid attack, a 5-min immersion in the test NaF solution (0, 1, 250, 500, 1,000, 1,750 and 2,500 ppm F), and to 21 h in an artificial saliva. Changes in mineral content were assessed weekly for 5 weeks using microradiography/microdensitometry. The lesions in the control group (0 ppm F) and the 1-ppm F group demineralized. Remineralization was significantly higher in the 500-ppm F group compared to the 250-ppm F group. However, higher fluoride concentrations did not produce any further significant increase in remineralization. Laminations were apparent in lesions subjected to the 250- and 500-ppm F solutions.
authors.affiliation: Department of Oral Medicine and Pathology, University of Glasgow, UK.
authors.forename: F A
authors.initials: FA
authors.lastname: Damato
authors.forename: R
authors.initials: R
authors.lastname: Strang
authors.forename: K W
authors.initials: KW
authors.lastname: Stephen
mesh_terms: D001641:Bicuspid; D003720:Densitometry / Q000706:statistics & numerical data; D003731:Dental Caries / Q000378:metabolism* / Q000628:therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008852:Microradiography; D012044:Regression Analysis; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D012969:Sodium Fluoride