title: Microcytosis, hypoferremia, hypoferritemia, and hypertransferrinemia in standardbred foals from birth to 4 months of age.
abstract: At birth, 24 Standardbred foals were assigned at random to 1 of 2 groups and were given a placebo supplement (group 1) or an iron supplement (248 mg of iron/treatment; group 2). Foals were given iron supplement or placebo 4 times during the second and third weeks after birth. Hematologic variables and general health were monitored until foals were 4 months old. Mean PCV in foals of both groups decreased during the first 2 weeks after birth, but values remained within adult horse reference ranges. During the first 6 weeks after birth, foal erythrocytes were smaller than adult horse erythrocytes, but foal erythrocyte glucose-6-phosphate dehydrogenase activity was greater than that in adult horses. At every measurement, indices of anisocytosis were lower in foals, compared with adult horse reference values, suggesting that foals have a homogeneous population of microcytic erythrocytes during early foalhood. In 2-week-old foals of both groups and in 4-week-old placebo-treated foals, mean serum iron concentration was lower than that in adult horses. In foals at birth and during the first 4 months, total iron-binding capacity values were above the adult reference range. In newborn foals, transferrin saturation percentage values decreased to below the reference range in foals from 2 weeks to 4 months after birth. When foals were born, serum ferritin concentration values were above the adult horse reference range, but decreased to within the reference range by the time foals were 1 day old. From 2 through 6 weeks after birth, foal ferritin concentration values were below the adult reference range.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
authors.forename: C W
authors.initials: CW
authors.lastname: Kohn
authors.forename: R M
authors.initials: RM
authors.lastname: Jacobs
authors.forename: D
authors.initials: D
authors.lastname: Knight
authors.forename: W
authors.initials: W
authors.lastname: Hueston
authors.forename: A A
authors.initials: AA
authors.lastname: Gabel
authors.forename: S M
authors.initials: SM
authors.lastname: Reed
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005293:Ferritins / Q000097:blood*; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D006736:Horses / Q000097:blood*; D007501:Iron / Q000008:administration & dosage / Q000097:blood*; D011247:Pregnancy; D011897:Random Allocation; D012016:Reference Values; D014168:Transferrin / Q000032:analysis*
chemical_list: D014168:Transferrin; D005293:Ferritins; D007501:Iron; D005954:Glucosephosphate Dehydrogenase