[Synthesis and pharmacologic properties of pranolium and its optical isomers].
Propranolol is a well-known powerful betareceptor-blocking agent. Its quaternary dimethyl derivative, designated as pranolium was firstly prepared by Lucchesi. Compared to propranolol it possesses no betareceptor-blocking activity and no local anaesthetic properties but shows the same antiarrhythmic action as the starting material. The synthesis of pranolium and its optical isomers starting from the corresponding propranolol derivatives is described. Their pharmacological activities have been tested. No significant differences regarding the pharmacological action could be observed.
Foken
H
H
VEB Isis-Chemie, Zwickau.
Gerbsch
S
S
Schmauder
H P
HP
Heyde
R
R
Lohmann
D
D
Hagen
A
A
Grünheid
K
K
Flöther
F U
FU
Gröger
D
D
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003327:Coronary Disease / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007536:Isomerism; D007545:Isoproterenol / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D011433:Propranolol / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000889:Anti-Arrhythmia Agents; C002616:pranolium; D006003:Glycogen; D011433:Propranolol; D007545:Isoproterenol; D000157:Aconitine
Synthese und pharmakologische Eigenschaften von Pranolium und seinen optischen Isomeren.