[The interaction of cytostatic compounds with urinary enzymes. 1. The influence on acylase from the human kidney].
Acylase, a cytosolic carboxypeptidase of human kidneys, is inhibited by various xenobiotics as well as by the physiological pH of human urine in the range of pH 4.5-5.8. Caused by this, the enzyme is unsuited for the demonstration of nephrotoxic processes.
Hütter
H J
HJ
Institut für Pathologische Biochemie, Bereichs Medizin der Martin-Luther-Universität Halle-Wittenberg.
Pantschewa-Haschen
R
R
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000201:enzymology*; D015262:Xenobiotics / Q000494:pharmacology*
D000970:Antineoplastic Agents; D015262:Xenobiotics; D000581:Amidohydrolases; C019665:amidase
Die Wechselwirkung von cytostatischen Verbindungen mit Harnenzymen. 1. Mitteilung: Einfluss auf Acylase menschlicher Niere.