The structure of tautomycin, a dialkylmaleic anhydride antibiotic.
The chemical structure of tautomycin (C41H66O13) was determined by chemical degradation, spectroscopic analysis and 2D INADEQUATE of tautomycin labeled with [1,2-13C]acetate. Tautomycin exists in methanol-buffer solution (1% diethylamine-formic acid, pH 7.3) as an equilibrium mixture of a 2,3-dialkylmaleic anhydride and its dicarboxylic acid in a ratio of approximately 5:4.
Cheng
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Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
Ubukata
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M
Isono
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D000107:Acetylation; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004952:Esters; D005285:Fermentation; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008745:Methylation; D015394:Molecular Structure; D011714:Pyrans; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013141:Spiro Compounds
D000935:Antifungal Agents; D004952:Esters; D011714:Pyrans; D013141:Spiro Compounds; C053079:tautomycin