title: Prophylaxis of oxalate urolithiasis with alkaline citrates.
abstract: Hypocitraturia, hypercalciuria, hypokalaemia, and some form of acidosis are often characteristic accompanying symptoms of calcium containing urinary stone formation. These alterations may be controlled or normalized with the administration of alkaline citrates which slow the relative growth rate of calcium oxalate crystals down. In response to the administration of a single 2-g dose of Magurlit granulate, also regarded as alkaline citrate, citrate excretion increases, urinary Ca/citrate, Ca/creatinine, and Ca.P/creatinine quotients decrease. Since these changes of the urinary constituents are advantageous as far as the prophylaxis of stone formation is considered and may be observed following the administration of other citrate mixtures as well the application of Magurlit is recommended for the prevention of calcium oxalate stones and for the treatment of distal renal tubular acidosis.
authors.affiliation: Department of Urology, Semmelweis University School of Medicine, Budapest.
authors.forename: D
authors.initials: D
authors.lastname: Frang
authors.forename: M
authors.initials: M
authors.lastname: Berényi
authors.forename: R
authors.initials: R
authors.lastname: Szebeni
mesh_terms: D002951:Citrates / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D010070:Oxalates / Q000378:metabolism*; D011736:Pyridoxine / Q000494:pharmacology / Q000627:therapeutic use*; D014545:Urinary Calculi / Q000517:prevention & control* / Q000652:urine
chemical_list: D002951:Citrates; D004338:Drug Combinations; D010070:Oxalates; C008309:magnesium citrate, potassium citrate, pyridoxine HCl, sodium citrate drug combination; D011736:Pyridoxine