Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats.
The hepatoprotective effect of Garcinia kola seed extract was investigated in rats treated with high doses of paracetamol. The extracts when administered at 100 mg/kg three times a day for five consecutive days reduced paracetamol- (800, 1000, 1200 mg/kg) induced lethality from 50, 90 and 100% to 0, 20 and 40%, respectively. There was a significant reduction in the liver enzymes SGOT and SGPT and histology scores. The hepatoprotective effect of the extract may be due to inhibition of cytochrome P-450 which normally converts paracetamol to the toxic intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI).
Akintonwa
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A
Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
Essien
A R
AR
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D009549:Nigeria; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012639:Seeds / Q000032:analysis*
D010936:Plant Extracts; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase