title: Genotoxicity of the pesticide propoxur and its nitroso derivative, NO-propoxur, on human lymphocytes in vitro.
abstract: The aim of this work was to investigate whether the pesticide propoxur and its nitroso derivative nitroso-propoxur increased the frequencies of sister-chromatid exchanges and micronuclei in human lymphocytes in vitro. The results show that both chemicals were genotoxic in the tested system.
authors.affiliation: Instituto de Oncologia Angel H. Roffo, Departmento de Investigaciones, Servicio de Carcinogenesis Química y Ambiental, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez Cid
authors.forename: D
authors.initials: D
authors.lastname: Loria
authors.forename: E
authors.initials: E
authors.lastname: Matos
mesh_terms: D002453:Cell Cycle; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D009153:Mutagens; D001074:Propoxur / Q000031:analogs & derivatives* / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D009153:Mutagens; C063383:N-nitrosopropoxur; D001074:Propoxur