Effect of dietary fat and monoclonal antibody therapy on the growth of human mammary adenocarcinoma MX-1 grafted in athymic mice.
A diet containing 11% per weight fish oils (Max-EPA) reduced the rate of growth of a transplantable human breast tumor (MX-1) grafted into immunodeficient mice (BALB/c, nu/nu) when compared to MX-1 tumors in mice fed polyunsaturated (corn oil) and saturated (lard) fatty acids; however, there was no difference between the corn oil and lard animal groups. Treatment with a cocktail of monoclonal antibodies (MoAbs) decreased the rat of growth of MX-1 in the corn oil fed animals but not in those fed lard or Max-EPA, but the rate of tumor growth of the Max-EPA treated group, either MoAb treated or not, was slower than that of the corn oil and lard groups.
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John Muir Cancer & Aging Research Institute, Walnut Creek, CA 94596.
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Ceriani
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D000230:Adenocarcinoma / Q000178:diet therapy / Q000628:therapy*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000178:diet therapy / Q000628:therapy*; D002460:Cell Line; D004041:Dietary Fats; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D004041:Dietary Fats; D005395:Fish Oils