Thymostimuline and uterine cancer satellite lymph nodes. Morphometric comparison between an 8-day-before-surgery and a 14-day-before-surgery single treatment.
The Authors analyse the functional areas (cortical, paracortical, germinal center, medullary, histiocytosis of the sinuses) of regional lymph nodes in women having uterine carcinoma and previously treated with Thymostimuline, and who were operated on respectively 8 and 14 days after inoculation. They also evaluate the degree of significance when compared with a control group treated locally with a physiological solution. The number of lymph nodes examined is at least 5, and the stereological analysis was carried out with the use of a grid: 200 points, actual area 200 cm2, effective area at the level of the preparation 0.32 mm2 (250 X). The Authors examine the results obtained after 8 days' action by Thymostimuline, and, after 14 days, the difference between the 8-day-after and the 14-day-after administration results, and those between the cervical and the endometrial. 4 women with uterine cancer (Stages I and II) and treated with the same doses of physiological saline solution were used as controls.
Cappello
F
F
Department of Obstetrics and Gynecology, Schio Hospital, Italy.
Pomari
R
R
Tripodi
S
S
Notario
G
G
Corradi
G
G
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008198:Lymph Nodes / Q000032:analysis / Q000187:drug effects* / Q000473:pathology; D013949:Thymus Extracts / Q000494:pharmacology*; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery
D013949:Thymus Extracts; C031407:thymostimulin