title: Diagnosis and treatment of Neospora caninum infection in a dog.
abstract: Neospora caninum, a protozoan organism, caused extensor rigidity of the pelvic limbs in a 12-week-old dog. Diagnosis was based on results of muscle biopsy, neuroelectrodiagnostics, serotesting, and cell culture. Indirect fluorescent antibody (IFA) titer to N caninum was 1:800 at time of admission and 1:3,200 after 4 and 6 weeks. A reciprocal IFA titer of 50 to N caninum was also found in the CSF. Serotesting for T gondii was negative. Treatment with clindamycin followed by sulfadiazine and trimethoprim did not change the pelvic limb extensor rigidity, but other signs of minor neurologic dysfunction improved.
authors.affiliation: Virginia-Maryland Regional College of Veterinary Medicine, Department of Small Animal Clinical Sciences, Virginia Polytechnic Institute and State University, Blacksburg.
authors.forename: W H
authors.initials: WH
authors.lastname: Hay
authors.forename: L G
authors.initials: LG
authors.lastname: Shell
authors.forename: D S
authors.initials: DS
authors.lastname: Lindsay
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D001706:Biopsy / Q000662:veterinary; D002981:Clindamycin / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004359:Drug Therapy, Combination; D004576:Electromyography; D056890:Eukaryota / Q000276:immunology / Q000302:isolation & purification; D006614:Hindlimb / Q000503:physiopathology; D008297:Male; D009132:Muscles / Q000469:parasitology / Q000503:physiopathology; D011528:Protozoan Infections / Q000175:diagnosis / Q000188:drug therapy; D011529:Protozoan Infections, Animal; D013411:Sulfadiazine / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D000913:Antibodies, Protozoan; D013411:Sulfadiazine; D002981:Clindamycin; D014295:Trimethoprim