[Concentration of thiobarbituric acid-reactive substances (TBARS) in the plasma of patients with atherosclerosis with different localizations and different degrees of severity].
The concentration of thiobarbituric acid reactive substances (TBARS) formed as a result of lipid peroxidation and prostanoid metabolism was measured in the plasma of patients with coronary or peripheric atherosclerosis. From the results conclusions were deduced to the function of reactive O2-species in the atherogenesis. We found in plasma of patients with coronary as well as with peripheric atherosclerosis increased TBARS concentrations dependent on the dimension of atherosclerosis as an index of activation of reactive O2-species formation. The TBARS concentration correlated with the cholesterol and LDL-cholesterol concentration in plasma.
Schimke
I
I
Institut für Pathologische und Klinische Biochemie, Humboldt-Universität zu Berlin.
Romaniuk
P
P
Schimke
E
E
Papies
B
B
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D013858:Thiobarbiturates; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D013858:Thiobarbiturates; D014280:Triglycerides; D002784:Cholesterol; C029684:thiobarbituric acid; D010100:Oxygen
Konzentration Thiobarbitursäure-reaktiver Substanzen (TBARS) im Plasma von Patienten mit Atherosklerose unterschiedlicher Lokalisation und unterschiedlichen Schweregrades.