Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens.
In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.
Baldwin
D R
DR
Department of Thoracic Medicine, Dudley Road Hospital, Birmingham.
Andrews
J M
JM
Ashby
J P
JP
Wise
R
R
Honeybourne
D
D
D000284:Administration, Oral; D001980:Bronchi / Q000032:analysis*; D020682:Cefixime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D004334:Drug Administration Schedule; D006801:Humans; D009092:Mucous Membrane / Q000032:analysis; D013183:Sputum / Q000032:analysis*
D020682:Cefixime; D002439:Cefotaxime