Trichomycin B, a polyene macrolide from Streptomyces.
Two polyene macrolide, trichomycins A and B, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1,096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A.
Komori
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Research and Technology Group, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
D000935:Antifungal Agents / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009930:Organic Chemicals; D013302:Streptomyces / Q000378:metabolism*; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D003470:Culture Media; D009930:Organic Chemicals; C100192:hachimycin