title: Lysis of egg phosphatidylcholine vesicles by tricyclic carboxamide antitumor agents.
abstract: The stability of small unilamellar vesicles formed by egg phosphatidylcholine has been examined in the presence of 38 tricyclic carboxamide DNA-intercalating agents (19 phenylquinolines, 17 phenylbenzimidazoles, an acridine and an anthracene). Lysis of the vesicular membrane is time-dependent and also dependent on the concentration of the cytotoxic agent. The relative concentration of agent to cause a fixed degree of lysis in a fixed time, as measured by the release of encapsulated 6-carboxyfluorescein, is directly related to the relative hydrophobicity of the agents.
authors.affiliation: Department of Chemistry, School of Medicine, University of Auckland, New Zealand.
authors.forename: C J
authors.initials: CJ
authors.lastname: O'Connor
authors.forename: D P
authors.initials: DP
authors.lastname: Emery
authors.forename: H
authors.initials: H
authors.lastname: Tank
authors.forename: W A
authors.initials: WA
authors.lastname: Denny
authors.forename: J
authors.initials: J
authors.lastname: Sunamoto
mesh_terms: D000166:Acridines / Q000494:pharmacology; D000873:Anthracenes / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004337:Drug Carriers; D004355:Drug Stability; D008081:Liposomes; D010713:Phosphatidylcholines; D011804:Quinolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D000873:Anthracenes; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D004337:Drug Carriers; D008081:Liposomes; D010713:Phosphatidylcholines; D011804:Quinolines