[A karyotype and chromatin study of the peripheral blood lymphocytes of patients with pigmented skin neoplasms].
Rearrangements of genetic material in the peripheral blood lymphocyte nuclei have been found in patients with dysplastic pigmented nevi and malignant melanomas (15 cases), in contrast to the control (10 healthy persons). It is expressed as an increase in the number of chromosome aberrations in the karyotype and as a change of the Feulgen-positive substance correlation in the interphase nuclei of the given cells towards an increase in the active-functioning DNA structures.
Ganina
K P
KP
Naleskina
L A
LA
Kireeva
S S
SS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D002843:Chromatin / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000235:genetics*; D004273:DNA, Neoplasm / Q000648:ultrastructure; D006801:Humans; D007399:Interphase; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure*; D008545:Melanoma / Q000235:genetics* / Q000648:ultrastructure; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000235:genetics* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000235:genetics* / Q000648:ultrastructure
D002843:Chromatin; D004273:DNA, Neoplasm
Issledovanie kariotipa i khromatina limfotsitov perifericheskoĭ krovi bol'nykh pigmentnymi novoobrazovaniiami kozhi.