[Morphological and histochemical analysis of central effects of angiotensin-II after experience of emotional stress].
It was shown in our physiological study that angiotensin-II induced drinking behavior was changed in previously stress exposed rats as compared to control animals. In order to determine the structural basis of the data obtained in the morphology and histochemistry (nucleic acids concentration) of the nucleus paraventricularis (n. PV), nucleus supraopticus (n. SO) and subfornical organ (SFO) neurons were studied in rats of several experimental groups. The most pronounced changes manifested the shape increase of the neurons functional activity after angiotensin-II (A-II) infusion into control and especially into previously stressed rats were discovered in n. PV. It was supposed that the disturbance of A-II-induced drinking behavior in stressed rats might be mainly due to the disfunction of n. PV neurons.
Ishchenko
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AG
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*; D004327:Drinking Behavior / Q000187:drug effects*; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009696:Nucleic Acids / Q000032:analysis; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*; D013356:Subfornical Organ / Q000378:metabolism / Q000503:physiopathology; D013495:Supraoptic Nucleus / Q000378:metabolism / Q000503:physiopathology
D009696:Nucleic Acids; D000804:Angiotensin II
Morfologicheskiĭ i gistokhimicheskiĭ analiz tsentral'nogo éffekta angiotenzina-II na fone perenesennogo émotsional'nogo stressa.