title: Electroencephalographic observation on sheep and cattle with experimental cerebrocortical necrosis.
abstract: Nine Suffolk sheep and 4 Holstein cattle were employed to observe electroencephalographic changes in experimental cerebrocortical necrosis. Amprolium (600 mg/kg/day) alone was given intraruminally 6 sheep and 4 cattle, all of which showed neurological signs and abnormal electroencephalograms. Both amprolium and thiamine (200 mg/day) and thiamine (50 mg/day) alone were given 2 and 1 sheep, respectively, as controls, which did not show any abnormal signs. Abnormal electroencephalograms included continuous slow waves and long-lasting spindles, both of which appeared diffusely and were seen subclinically or with neurological signs. The spindles consisted of slow waves or sharp- (or spike-) and-slow-wave complexes with or without convulsive seizures even during the convulsion stage. Conversely, the seizures occurred with the spindles or slow waves.
authors.affiliation: Third Research Division, National Institute of Animal Health, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Itabisashi
authors.forename: R
authors.initials: R
authors.lastname: Horino
authors.forename: K
authors.initials: K
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Maeda
mesh_terms: D000670:Amprolium; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000473:pathology*; D004567:Electrodes, Implanted / Q000662:veterinary; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation / Q000662:veterinary*; D005260:Female; D008297:Male; D009336:Necrosis; D012756:Sheep; D012757:Sheep Diseases / Q000503:physiopathology*; D013831:Thiamine / Q000627:therapeutic use
chemical_list: D000670:Amprolium; D013831:Thiamine