Prediction of cancer potency using a battery of mutation and toxicity data.
Correlations between the carcinogenic potencies of 146 known mouse carcinogens and potency estimates determined from (i) Ames test results, (ii) a battery of mutation test results, and (iii) a battery of mutation and toxicity data are presented. The lowest correlation was found using Salmonella mutagenic potency (r = 0.37). The highest correlations were found using the battery of mutation and toxicity data to predict the potency of lung carcinogens (r = 0.94) and liver carcinogens (r = 0.91). The results suggest that short-term batteries which include tests for both mutagenicity and toxicity will be able to predict carcinogenic potency better than current batteries relying solely on mutagenicity tests.
Travis
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Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831-6109.
Saulsbury
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Pack
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D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D009374:Neoplasms, Experimental / Q000175:diagnosis* / Q000235:genetics
D002273:Carcinogens; D009153:Mutagens