[Biliary elimination and hepatic disposition of piperacillin: experimental evaluation].
The rate of biliary elimination and the hepatic disposition of piperacillin were studied by using an experimental model of a three hours perfusion of five isolated rabbit liver preparations. After addition of 10 mg of the antibiotic to the circulating blood, a mean biliary peak of 1,013 +/- 305 micrograms/ml was obtained between the 30th and 60th minute. The cumulated biliary elimination (0-3 hr) amounted to 5,665 +/- 389 micrograms (56.7% of the dose given). The hepatobiliary clearance was calculated to 134.2 ml/hr and the biliary elimination rate constant to 0.5 545 (h-1). After the procedure, 7.2 +/- 2.7% of the dose of piperacillin was still present in the circulating blood and 0.4 +/- 0.1% in the liver. The degradation of the antibiotic in the perfusion device concerned 24.9% of the dose. The percentage of piperacillin undergoing hepatic biotransformation, calculated by subtraction, was 10.8%. Under these conditions, the biliary elimination of piperacillin is much higher than that of the twenty other beta-lactams studied in our laboratory by the same experimental procedure.
Brogard
J M
JM
Département de Médecine Interne de la Clinique Médicale B, Université Louis-Pasteur, Strasbourg.
Dorner
M
M
Blickle
J F
JF
Jehl
F
F
Monteil
H
H
D000818:Animals; D001659:Biliary Tract / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008099:Liver / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D010878:Piperacillin / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
D010878:Piperacillin
Elimination biliaire et disposition hépatique de la pipéracilline: évaluation expérimentale.