[Functional testing of the immunotoxicity of the phenoxyalkane acid mecoprop in rats and prevention of immunotoxic effects by adrenalectomy].
Mecoprop caused in former toxicological examinations time and dose dependent changes of structural components of the immune system. By investigation of humoral and cell immunity was to test, if functional parameter are also influenced by the substance. Mecoprop decreased the delayed hypersensitivity as parameter of cell immunity. The haemagglutination titer against sheep erythrocytes was not influenced by the substance. But the decrease of IgG-concentration in the serum shows also an effect of Mecoprop on the humoral immunity. Adrenalectomy was carried out to test, if there is an indirect mechanism of the action on the immune system, which is mediated by the activity of adrenals. The results show a nearly complete elimination of substance effects in adrenalectomized animals.
Moeller
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Institut für Pflanzenschutzforschung der Akademie der Landwirtschaftswissenschaften der DDR.
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000633:toxicity*; D000302:Adrenal Cortex / Q000187:drug effects*; D000315:Adrenalectomy; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000502:physiology; D006016:Glycolates / Q000633:toxicity*; D006540:Herbicides; D007108:Immune Tolerance / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D051381:Rats
D005938:Glucocorticoids; D006016:Glycolates; D006540:Herbicides; C008340:mecoprop; D008456:2-Methyl-4-chlorophenoxyacetic Acid
Funktionelle Testung der Immunotoxizität der Phenoxyalkansäure Mecoprop an Ratten und Ausschaltung immuntoxischer Effekte durch Adrenalektomie.