[Human malaria: dysglobulinemia-hypocholesterolemia syndrome].
Comparative study of protein and lipid parameters within a homogenous sample of 144 non-immune subjects having stayed for four months in Central Africa, suggests a dysglobulinemia more significant in the infected group. This dysglobulinemia affects in particular the IgM which are negatively correlated with cholesterol, positively with apoproteins A2 and H.D.L. Such a peculiar profiling involving immunoglobulins, apoproteins and cholesterol is rapidly regressive after stopping exposure to parasitic risk. It appears as an adaptation syndrome--or resistance--to tropical environment.
Cuisinier-Raynal
J C
JC
Centre d'Etudes Métaboliques et Tropicales, Hôpital d'Instruction des Armées R. Picque, Bordeaux Armées.
Bire
F
F
Clerc
M
M
Bernard
J
J
Sarrouy
J
J
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001059:Apoproteins / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D004406:Dysgammaglobulinemia / Q000097:blood* / Q000276:immunology; D005602:France / Q000208:ethnology; D005681:Gabon; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008288:Malaria / Q000097:blood* / Q000276:immunology; D008889:Military Personnel
D001059:Apoproteins; D008076:Cholesterol, HDL; D007075:Immunoglobulin M
Paludisme. Le syndrome dysglobulinémie--hypocholestérolémie.