Heartworm migration toward right atrium following artificial pulmonary arterial embolism or injection of heartworm body fluid.
Heartworms harboring in the pulmonary arteries migrated toward the right atrium following insertion of dead heartworms or heartworm-like silicone tubes, or intravenous injection of body fluid extract of a female heartworm. The migration occurred within 3 hr (early group) or 1 to 7 days (late group) after insertion of dead worms, 1 to 11 days after insertion of silicone tubes, and immediately after infusion of heartworm-body fluid. The cardiac output decreased to an unmeasurably low level, and the pulmonary arterial pressure was also reduced in the early group. Although the output decreased, the pulmonary arterial pressure and the total pulmonary resistance increased gradually in the late group. In dogs with heartworm migration, in which silicone tubes had been inserted, the changes in cardiopulmonary values were the same as those in dogs of the late group. In dogs to which the body fluid had been administered intravenously, the changes in cardiopulmonary values were well accord with those in the early group. The systemic blood pressure also fell immediately after the administration with the shock-like state. These results suggest that the death of a part of the heartworms may be closely associated with the migration of heartworms toward the right atrium through the pulmonary arterial embolism and/or shock-like reaction by heartworm body fluid.
Kitagawa
H
H
Laboratory of Internal Medicine, Faculty of Agriculture, Gifu University, Japan.
Sasaki
Y
Y
Ishihara
K
K
Kawakami
M
M
D000818:Animals; D001826:Body Fluids; D004182:Dirofilaria / Q000502:physiology*; D004285:Dogs; D005260:Female; D005370:Filarioidea / Q000502:physiology*; D006321:Heart / Q000469:parasitology*; D006325:Heart Atria / Q000469:parasitology; D007269:Injections, Intra-Arterial / Q000662:veterinary; D008297:Male; D011651:Pulmonary Artery / Q000469:parasitology*; D011655:Pulmonary Embolism / Q000469:parasitology / Q000662:veterinary*