Feed intake after inhibition of histamine catabolism.
It has been reported that histamine and its precursor histidine have a feeding-suppressing effect. The present study shows that metoprine (20 mg/kg i.p.), which increases brain histamine levels by inhibiting its catabolism, also significantly decreases daily feed intake in rats. The reduced feed consumption is evident in different states of water balance. These results agree with an involvement of histaminergic systems in the regulation of feeding behaviour.
Lecklin
A
A
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Tuomisto
L
L
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005493:Folic Acid Antagonists / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D006639:Histidine / Q000031:analogs & derivatives*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005493:Folic Acid Antagonists; D008762:Methylhistidines; C006308:metoprine; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D011739:Pyrimethamine