title: [The relationship between the chemical structure and anti-arrhythmia action of a number of omega-aminoacyl-3-carbalcoxyaminodibenzazepines].
abstract: The antiarrhythmic activity of 20 derivatives of dibenzazepine (the effects on the maximal effective rabbit heart auricle contraction rate, aconitine-induced arrhythmia in rats under or without anesthesia) was studied. It was shown that the most active compounds are those with carbethoxyamine group in position 3 in combination with dimethylamino- or diethylamino-acetyl groups in position 5 of dibenzazepine ring. 5-dimethyl-aminoacetyl-10,11-dihydro-5H-dibenz b, f azepine (GS-015, bonnecor) was selected for the further detailed investigation.
authors.forename: A N
authors.initials: AN
authors.lastname: Gritsenko
authors.forename: V V
authors.initials: VV
authors.lastname: Lyskovtsev
authors.forename: Z P
authors.initials: ZP
authors.lastname: Senova
authors.forename: A P
authors.initials: AP
authors.lastname: Skoldinov
authors.forename: A
authors.initials: A
authors.lastname: Stark
authors.forename: G
authors.initials: G
authors.lastname: Wunderlich
authors.forename: H
authors.initials: H
authors.lastname: Poppe
authors.forename: R
authors.initials: R
authors.lastname: Barch
mesh_terms: D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D003984:Dibenzazepines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine; D000157:Aconitine
vernacular_title: Izuchenie zavisimosti mezhdu khimicheskim stroeniem i antiaritmicheskim deĭstviem v riadu omega-aminoatsil-3-karbalkoksiaminodibenzazepinov.