title: Thrombosis in a mechanical aortic valve prosthesis during subcutaneous heparin therapy in pregnancy; a case report.
abstract: Maternal death due to thrombosis in a mechanical aortic valve prosthesis during heparin therapy is described. The patient had a normal pregnancy during warfarin therapy. In this pregnancy, warfarin therapy was replaced by subcutaneous heparin injections, and the patient died of massive thrombosis in the valvuloprosthesis at 20 weeks of pregnancy. The effectiveness of heparin therapy and difficulties in the follow-up of heparin treatment during pregnancy are discussed.
authors.affiliation: Department of Obstetrics and Gynecology, University of Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Tapanainen
authors.forename: M
authors.initials: M
authors.lastname: Ikäheimo
authors.forename: P
authors.initials: P
authors.lastname: Jouppila
authors.forename: M L
authors.initials: ML
authors.lastname: Kortelainen
authors.forename: P
authors.initials: P
authors.lastname: Salmela
mesh_terms: D000328:Adult; D001021:Aortic Valve; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D013927:Thrombosis / Q000209:etiology*
chemical_list: D006493:Heparin