Leishmania infecting man and wild animals in Saudi Arabia. 7. Partial protection of mice against Leishmania major by prior infection with L. arabica.
A survey of inbred mouse strains showed that strain C3H/he was the most comparable to man in respect of its susceptibility to Leishmania major and the subsequent healing of lesions produced by this organism. L. arabica proved to have a lower virulence than L. major and prior inoculation with the former resulted in a decrease of the lesion sizes following subsequent L. major challenge. Moreover, L. major lesions that did develop in mice previously inoculated with L. arabica generally healed faster.
Neal
R A
RA
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK.
Reeves
A
A
Peters
W
W
D000818:Animals; D000835:Animals, Wild / Q000469:parasitology*; D000917:Antibody Formation; D006224:Cricetinae / Q000469:parasitology*; D004198:Disease Susceptibility; D006801:Humans; D007891:Leishmania / Q000472:pathogenicity*; D007895:Leishmania tropica / Q000472:pathogenicity*; D007896:Leishmaniasis / Q000276:immunology* / Q000469:parasitology; D008647:Mesocricetus / Q000469:parasitology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000469:parasitology*; D012529:Saudi Arabia; D013045:Species Specificity; D013997:Time Factors; D014774:Virulence