Genotoxicity of the pesticide propoxur and its nitroso derivative, NO-propoxur, on human lymphocytes in vitro.
The aim of this work was to investigate whether the pesticide propoxur and its nitroso derivative nitroso-propoxur increased the frequencies of sister-chromatid exchanges and micronuclei in human lymphocytes in vitro. The results show that both chemicals were genotoxic in the tested system.
Gonzalez Cid
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M
Instituto de Oncologia Angel H. Roffo, Departmento de Investigaciones, Servicio de Carcinogenesis Química y Ambiental, Buenos Aires, Argentina.
Loria
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D
Matos
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E
D002453:Cell Cycle; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D009153:Mutagens; D001074:Propoxur / Q000031:analogs & derivatives* / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D009153:Mutagens; C063383:N-nitrosopropoxur; D001074:Propoxur