[Studies on chemical protectors against radiation. XXVIII. Protective effect of nucleic acid constitutional compounds on radiation damages induced by X-irradiation].
The effects of various nucleic acid constitutional compounds, base, nucleoside and nucleotide on lethality and skin injury induced by soft X-irradiation were studied. The survival effect was determined by use of survival days after irradiation of lethal dose of 70 kVp, 2100R and the protective effect on skin injury was determined by use of degrees on skin injury after 30 kVp, 1100R soft X-irradiation. As a result of these studies, the survival effect was observed by single injection of inosine at 120, 60 and 5 min before irradiation and three times injection after irradiation. And the other nucleic acid constitutional compounds had no effect on survival. Protective effect of skin injury was observed by single injection of adenosine, guanosine, inosine, 5'-adenosine monophosphate (5'-AMP), 5'-guanosine monophosphate (5'-GMP) and 5'-inosine monophosphate (5'-IMP) before irradiation. Protective effect of skin injury by three time injection before irradiation were revealed in adenosine, inosine, 5'-AMP and 5'-IMP. For the investigation of superoxide anions and hydroxyl radicals scavenge activities, the relationship between radical scavenge activities and protective effect of radiation by using various nucleosides was not observed.
Sato
Y
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Ohta
S
S
Shinoda
M
M
D000241:Adenosine / Q000627:therapeutic use*; D000818:Animals; D005609:Free Radicals; D007288:Inosine / Q000627:therapeutic use*; D051379:Mice; D011684:Purine Nucleosides / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*
D005609:Free Radicals; D011684:Purine Nucleosides; D007288:Inosine; D000241:Adenosine