title: [Electron microscopy studies of the collagen fiber structure of the human tympanic membrane in an adhesive process].
abstract: In an EM study, the collagen fiber arrangement of the lamina propria in adhesive otitis media was investigated. Nine biopsies of the tympanic membrane were taken intraoperatively, and compared with two normal ones. The physiological specimens showed a regular arrangement of collagen fibrils and fibers, the typical network of the lamina propria. This confirmed results reported previously. In all adhesive otitis media samples the regular structure of the fiber arrangement was disturbed. Degenerative processes were to be found in the form of hyaline changes, with the network character of the fibers no longer in evidence. In one specimen a mass of microfibrils was observed, which was possibly a sign of reparative processes. The pathohistological findings in adhesive otitis media may be due to mechanical stresses (tubal function). Aside from that, they may also be caused by the biochemical influence of specific collagenases, which have been found by several authors in secretory otitis was well as in cholesteatoma.
authors.affiliation: Universitäts-HNO-Klinik Hamburg Eppendorf.
authors.forename: J
authors.initials: J
authors.lastname: Hartwein
authors.forename: K
authors.initials: K
authors.lastname: Mensing
authors.forename: G
authors.initials: G
authors.lastname: Schaeg
authors.forename: H W
authors.initials: HW
authors.lastname: Pau
mesh_terms: D001706:Biopsy; D002781:Cholesteatoma / Q000473:pathology*; D003094:Collagen / Q000648:ultrastructure*; D006801:Humans; D008854:Microscopy, Electron; D010034:Otitis Media with Effusion / Q000473:pathology*; D000267:Tissue Adhesions; D014432:Tympanic Membrane / Q000473:pathology*; D014433:Tympanoplasty
chemical_list: D003094:Collagen
vernacular_title: Elektronenoptische Untersuchungen zur Kollagenfaserstruktur des menschlichen Trommelfells beim Adhäsivprozess.