title: A cytotoxic antibody produced by allo-skin transplantation in cats.
abstract: A high titer of cytotoxic antibody against donor lymphocytes, tentatively designated as anti-F1, was found in one cat who received 3 times of skin allograft from the same donor. The anti-F1 antibody titer was 1:16, and the antibody activity was mostly detected in the IgG fraction. A cross-absorption test using erythrocytes from F1-positive animals revealed that the F1(+) antigen recognized by anti-F1 antibody was expressed on erythrocytes as well as lymphocytes. The frequencies of F1(+) and F1(-) types in 81 healthy cats, involving all the cats used for allo-immunization in the present study, were 30.9 and 69.1%, respectively. Moreover, F1 antigen was considered to be a hereditary antigen from family studies.
authors.affiliation: Department of Surgery, School of Veterinary Medicine, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Ejima
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Tagawa
authors.forename: S
authors.initials: S
authors.lastname: Motoyoshi
authors.forename: S
authors.initials: S
authors.lastname: Ikemoto
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D000941:Antigens / Q000235:genetics*; D002415:Cats / Q000097:blood / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D016038:Skin Transplantation / Q000276:immunology*; D013045:Species Specificity; D014184:Transplantation, Homologous
chemical_list: D000906:Antibodies; D000941:Antigens; D007074:Immunoglobulin G