title: SPECT quantification of cerebral ischemia before and after carotid endarterectomy.
abstract: A method to assess changes in cerebral perfusion following carotid endarterectomy was developed using late (2 hr)/early (20 min) single-photon emission computed tomography (SPECT)/[123I]iodoamphetamine count ratios. Using a ratio greater than 1.0 to indicate redistribution and reversible ischemia, pre- and postoperative studies were compared for 20 patients. Regional polar plots based on 30 degrees angular sectors showed improvement greater than 2 standard deviations (s.d.s) ipsilateral to surgery in 15/19 (79%) and contralateral to the side of surgery in 8/19 (42%) patients with significant hemodynamic lesions. Using a hemispheric perfusion index (mean of four 30 degrees sectors) ipsilateral perfusion improved in 11/19 (58%) with bilateral improvement in 6/19 (32%). Visual interpretation was similar to the regional analysis with 14/19 (74%) improving on the operative side; however, it was less sensitive for contralateral changes, 4/19 (21%). We conclude that quantitation of redistribution can provide an objective index of improved perfusion and is especially important to detect contralateral changes.
authors.affiliation: Department of Diagnostic Imaging, Temple University Hospital, Philadelphia, Pennsylvania 19140.
authors.forename: A H
authors.initials: AH
authors.lastname: Maurer
authors.forename: J A
authors.initials: JA
authors.lastname: Siegel
authors.forename: A J
authors.initials: AJ
authors.lastname: Comerota
authors.forename: W A
authors.initials: WA
authors.lastname: Morgan
authors.forename: M H
authors.initials: MH
authors.lastname: Johnson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000601:surgery; D002339:Carotid Arteries / Q000601:surgery*; D002560:Cerebrovascular Circulation; D004691:Endarterectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; C041336:4-iodoamphetamine