title: [Combined treatment of rectal cancer using intensive macrofractional preoperative irradiation].
abstract: The article discusses the results of a cooperative randomized study according to evaluation of the efficacy of combined treatment in 451 patients among which 248 patients received an intensive course of macrofractional irradiation in cumulative local dose of--25 Gr. Intensive macrofractional irradiation increases neither the frequency of postoperative complications nor the mortality rate. At the same time, the combined method of treatment leads to a significant reduction in the frequency of a recurrent tumor and an increase in 5-year survival, particularly among patients with a stage III tumorous process. Combination of radiotherapy and surgery with the use of local UHF hyperthermia is the method of choice in the treatment of squamous cell carcinoma of the anal canal.
authors.forename: V I
authors.initials: VI
authors.lastname: Knysh
authors.forename: G V
authors.initials: GV
authors.lastname: Bondar'
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Barsukov
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Timofeev
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Basheev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000601:surgery*; D012007:Rectum / Q000528:radiation effects / Q000601:surgery*
vernacular_title: Kombinirovannoe lechenie raka priamoĭ kishki s ispol'zovaniem intensivnogo krupnofraktsionnogo predoperatsionnogo oblucheniia.