High incidence of endogenous depression in migraine: confirmation by tyramine test.
Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.
Jarman
J
J
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
Fernandez
M
M
Davies
P T
PT
Glover
V
V
Steiner
T J
TJ
Thompson
C
C
Rose
F C
FC
Sandler
M
M
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D010556:Personality Tests; D014439:Tyramine / Q000652:urine
D014439:Tyramine