[The preclinical assessment of the activity and pharmacological action of native human interleukin-2].
It was demonstrated in in vivo and in vitro experiments that interleukin-2, obtained by cultivation of donor lymphocytes and purified by gel filtration, induces the production of mouse and human killer lymphocytes possessing high cytolytic activity against tumor cells. Interleukin-2 does not cause irreversible changes of the physiological and morphologic indices of vital activity in mice.
Malakhova
N V
NV
Treshchalin
I D
ID
Iobadze
M S
MS
Abronina
I F
IF
Bykovskaia
S N
SN
Iushkov
S F
SF
Pereverzeva
E R
ER
Syrkin
A B
AB
Raushenbakh
M O
MO
D000818:Animals; D000970:Antineoplastic Agents; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects / Q000276:immunology; D007941:Leukemia P388 / Q000188:drug therapy / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000276:immunology
D000970:Antineoplastic Agents; D007376:Interleukin-2
Predklinicheskaia otsenka aktivnosti i farmakologicheskogo deĭstviia nativnogo interleĭkina-2 cheloveka.