[Potential cardiotonic agents. 6. Synthesis and cardiovascular properties of 5-(4-pyridinyl)-, 6-methyl-5-(4-pyridinyl)- and 6-methyl-5-phenyl-substituted 3-cyano-2-oxaalkyoxy-pyridines].
The headline compounds were prepared by the reaction of 2-chloropyridines 1-3 with the appropriate alcohols in presence of potassium hydroxide and the sodium alkoxides, respectively. Especially some of the 3-cyano-2-hydroxyalkoxy-5-(4-pyridinyl)pyridines showed remarkable positive inotropic potency and, additionally, a vasodilator activity. In spontaneously beating isolated guinea pig atria they had a greater activity than amrinone.
Hagen
V
V
Akademie, Wissenschaften, DDR.
Klauschenz
E
E
Rumler
A
A
Hagen
A
A
Heer
S
S
Mitzner
R
R
Niedrich
H
H
Lohmann
D
D
D000676:Amrinone / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004285:Dogs; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D020105:Milrinone; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002316:Cardiotonic Agents; D009570:Nitriles; D011725:Pyridines; D011728:Pyridones; D020105:Milrinone; D000676:Amrinone
Potentielle Kardiotonika. 6. Mitteilung: Darstellung und kardiovaskuläre Eigenschaften von 5-(pyrid-4-yl)-, 6-methyl-5-(pyrid-4-yl)- und 6-methyl-5-phenylsubstituierten 3-Cyan-2-oxaalkoxy-pyridinen.