[The role of maternal virus-specific cytotoxic T-lymphocytes in the immunopathology of congenital influenza infection in mice].
Using 51Cr isotope label it was demonstrated that a very low per cent of syngeneic lymphocytes derived from healthy donors and inoculated in the blood stream of uninfected or influenza virus-infected pregnant mice is found in fetuses before delivery. Similar results were obtained after inoculation of virus-specific cytotoxic lymphocytes (CTL) into uninfected pregnant mice. After inoculation into the blood stream of infected pregnant mice of virus-specific CTL their migration into fetuses before delivery increases, being most marked in 25-30% of mice. Intravenous inoculation of excess CTL (10(6) cells) to infected pregnant mice resulted in rapid development of signs of slow influenza infection in the progeny with typical clinical picture and histopathological lesions in organs and tissues. Large doses (10(7)-10(8) cells) of CTL inoculated into the blood stream cause higher reduction and death of fetuses and increase the rate of stillbirths. The role of maternal virus-specific CTL in the pathogenesis of experimental congenital and especially slow influenza infection is discussed.
Gordeeva
M S
MS
Nefedova
N B
NB
Zuev
V A
VA
D000818:Animals; D002860:Chromium Radioisotopes; D005260:Female; D005333:Fetus / Q000276:immunology; D007154:Immune System Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D009980:Influenza A virus / Q000276:immunology*; D008431:Maternal-Fetal Exchange / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000151:congenital / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D012897:Slow Virus Diseases / Q000150:complications / Q000151:congenital / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000637:transplantation
D002860:Chromium Radioisotopes
Rol' materinskikh virusspetsificheskikh tsitotoksicheskikh T-limfotsitov v immunopatologii pri vrozhdennoĭ grippoznoĭ infektsii u mysheĭ.