[Experimental study of the effect on the liver of cortisol after diverting the adrenal venous circulation into the portal circulation].
In order to evaluate the operation of the adrenal autotransplantation into omentum with arterio-venous anastomosis, the right adrenal of fifteen dogs was preliminarily removed and then the left adrenal vein was diverted into the portal circulation by micro surgical technique. Before and after the diversion, the serum cortisol taken from portal vein, hepatic vein, inferior vena cava and peripheral vein was analysed by radioimmunoassay. The dog's adrenal cortex, pituitary were removed for light and electron-microscopic examination. The experimental results demonstrate that the cortisol inactivation effect of the liver was not statistically different before and after the procedure (P greater than 0.05). Thus, we believe that the omentum which has obvious absorbability and revascularity is a reasonable site for adrenal transplantation. And we also found the adrenal cortex left appear slight hypotrophy and pituitary hypertrophy after the diversion. The cause however, requires further research.
Zhou
X B
XB
First Affiliated Hospital of Henan Medical University, Zhengzhou.
D000311:Adrenal Glands / Q000098:blood supply*; D000714:Anastomosis, Surgical; D000818:Animals; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011169:Portal Vein / Q000601:surgery*; D014680:Veins / Q000601:surgery
D006854:Hydrocortisone