title: [Neopterin as a marker of aspecific immunostimulation with Propionibacterium avidum KP-40 in patients with gastrointestinal tumors. A prospective randomized study].
abstract: This prospective randomized study demonstrated that a preoperative intravenous infusion of 10 mg of the bacterial preparation Propionibacterium avidum KP-40 to patients with gastrointestinal tumors significantly (P less than 0.001) enhanced the secretion of neopterin, measurable as long-lasting (greater than 16 days) elevated urine excretion. Postoperative re-infusion of P. avidum KP-40 caused (statistically significant (p less than 0.001] re-enhancement of neopterin urine levels.
authors.affiliation: Orthopädische Klinik der Medizinischen Fakultät der RWTH Aachen.
authors.forename: K M
authors.initials: KM
authors.lastname: Peters
authors.forename: B
authors.initials: B
authors.lastname: Bornhofen
authors.forename: R
authors.initials: R
authors.lastname: Grundmann
authors.forename: H L
authors.initials: HL
authors.lastname: Ko
authors.forename: J
authors.initials: J
authors.lastname: Beuth
authors.forename: W
authors.initials: W
authors.lastname: Waters
authors.forename: H
authors.initials: H
authors.lastname: Pichlmaier
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001708:Biopterins / Q000031:analogs & derivatives* / Q000652:urine; D015179:Colorectal Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D007114:Immunization; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D011424:Propionibacterium; D011446:Prospective Studies; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000628:therapy*
chemical_list: D014408:Biomarkers, Tumor; D001708:Biopterins; D019798:Neopterin
vernacular_title: Neopterin als Marker einer unspezifischen Immunstimulation mittels Propionibacterium avidum KP-40 bei Patienten mit gastrointestinalen Tumoren. Eine prospektiv randomisierte Studie.