[Gastrinoma and carcinoma-carcinoid tumor causing Zollinger-Ellison syndrome].
7 gastrinomes and 1 gastrin-producer complex carcinoma-carcinoid tumor were examined by light and electron microscopical-method and by immunohistochemical method. In six cases, the tumor was in the pancreas or in the wall of duodenum; in two cases its localisation was of extra-gastroenteropancreatic (liver, lymph node). All patients developed Zollinger-Ellison syndrome, three patients bled and one had diarrhea. One patient had other tumors, besides gastrinome, which were characteristic of MEN-I syndrome. By immunohistochemical methods all tumors proved to be gastrin and neuron-specific-enolase positive. In four cases somatostatin positivity, in some cases glucagon, pancreatic polypeptide, S-100 protein, keratin and carcinoembryonal antigen positivity were detected. Relation could not be detected between other polypeptide hormones, produced besides gastrin, and biological behaviour of tumor and clinical symptoms.
Lászik
Z
Z
Szent-Györgyi Albert Orvostudományi Egyetem Pathológiai Intézet, Sebészeti Klinika.
Krenács
T
T
Baltás
B
B
Karácsonyi
S
S
Pap
A
A
D002276:Carcinoid Tumor / Q000032:analysis / Q000150:complications / Q000378:metabolism; D002277:Carcinoma / Q000032:analysis / Q000150:complications / Q000378:metabolism; D004379:Duodenal Neoplasms / Q000032:analysis / Q000150:complications / Q000378:metabolism*; D005755:Gastrins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000150:complications / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000032:analysis / Q000150:complications / Q000378:metabolism*; D015043:Zollinger-Ellison Syndrome / Q000209:etiology*
D005755:Gastrins
Zollinger-Ellison-szindrómát okozó gastrinomák és carcinoma-carcinoid tumor.