131I-labelled monoclonal antibody H17E2 in the detection of subcutaneous metastasis from gestational choriocarcinoma.
Subcutaneous metastasis is an uncommon finding in gestational choriocarcinoma. We detected such a lesion by external radioimmunoscintigraphy in a patient with gestational choriocarcinoma using 131-I labelled H17E2 monoclonal antibody raised against placental alkaline phosphatase. On the contrary, no positive image of the same metastasis was taken using 131-I labelled non-specific 11.4.1 monoclonal antibody. The successful detection of occult metastatic deposits in choriocarcinoma, which have become resistant to chemotherapy, may be of value for the potential use of curative surgery in these patients.
Athanassiou
A
A
Metaxas Memorial Cancer Hospital, Piraeus, Greece.
Pectasides
D
D
Pateniotis
K
K
Tzimis
L
L
Lafi
A
A
Cross
A
A
Epenetos
A
A
D000328:Adult; D000469:Alkaline Phosphatase / Q000276:immunology*; D000911:Antibodies, Monoclonal; D002822:Choriocarcinoma / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D009362:Neoplasm Metastasis; D010920:Placenta / Q000201:enzymology*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D000469:Alkaline Phosphatase