title: Assessment of ventricular function in infants and children. Response to dobutamine infusion.
abstract: A method to assess ventricular functional reserve in infants and children unable to perform dynamic exercise was evaluated. Left ventricular ejection fraction was measured by radionuclide angiocardiography at rest and during infusion of dobutamine in 5-15 micrograms/kg/min dosages. The only side effects noted were arrhythmias in two patients, who had similar ectopy documented previously. Group left ventricular ejection fraction increased from 0.40 +/- 0.21 to a maximum of 0.49 +/- 0.24 (P less than 0.001). Left ventricular ejection fraction at 5 micrograms/kg/min (0.44 +/- 0.23) was not statistically different from that measured during infusion of dobutamine at 10 micrograms/kg/min (0.48 +/- 0.24). The six patients receiving anthracyclines, who had relatively low function at rest and increased function during dobutamine administration, were continued on their anticancer regimen without deteriorating in condition. Absolute values of left ventricular ejection fraction correlated best with the prognosis in patients with idiopathic dilated cardiomyopathy or structural abnormalities; six out of ten patients whose left ventricular ejection fraction never rose above 0.40 have either died or are in transplant protocols. Thus, study of left ventricular function can be performed easily during dobutamine infusion, generating valuable prognostic information.
authors.affiliation: Department of Pediatrics, Indiana University Medical School, Indianapolis.
authors.forename: R A
authors.initials: RA
authors.lastname: Hurwitz
authors.forename: A
authors.initials: A
authors.lastname: Siddiqui
authors.forename: R L
authors.initials: RL
authors.lastname: Caldwell
authors.forename: R M
authors.initials: RM
authors.lastname: Weetman
authors.forename: D A
authors.initials: DA
authors.lastname: Girod
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging; D002648:Child; D004280:Dobutamine; D005260:Female; D006321:Heart / Q000187:drug effects; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008297:Male; D011875:Radionuclide Angiography / Q000379:methods*; D013318:Stroke Volume
chemical_list: D000970:Antineoplastic Agents; D004280:Dobutamine