title: Neosporosis in dogs.
abstract: A bitch was inoculated subcutaneously and intramuscularly with Neospora caninum tachyzoites on Day 35 of pregnancy. Eight pups were born 28 days later. Five pups became ill and necropsies were performed before 20 days of age. Three pups and the bitch remained clinically normal for 7 weeks after parturition when they were intramuscularly injected with 40 mg kg-1 methylprednisolone acetate weekly to activate chronic N. caninum infection. Necropsies were performed 48, 17, 18, and 18 days respectively after administration of corticosteroids. Hepatic necrosis, pneumonia, encephalomyelitis, and myonecrosis were the main changes seen in these dogs.
authors.affiliation: U.S. Department of Agriculture, Livestock and Poultry Sciences Institute, Beltsville, MD 20705.
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
authors.forename: D S
authors.initials: DS
authors.lastname: Lindsay
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004283:Dog Diseases / Q000151:congenital / Q000473:pathology*; D004285:Dogs; D005260:Female; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009132:Muscles / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000662:veterinary; D011528:Protozoan Infections / Q000151:congenital / Q000473:pathology; D011529:Protozoan Infections, Animal