Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.
Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.
Ehrlich
K C
KC
Southern Regional Research Center, U.S. Department of Agriculture, New Orleans, Louisiana 70179.
Ehrlich
M
M
D000483:Alleles; D001053:Apolipoproteins / Q000235:genetics*; D053241:Apoprotein(a); D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D017270:Lipoprotein(a); D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D013379:Substrate Specificity
D001053:Apolipoproteins; D004268:DNA-Binding Proteins; D017270:Lipoprotein(a); D053241:Apoprotein(a)