title: [Narrow-band action potentials of the guinea-pig cochlea as compared with the ordinary electrocochleograms under normal and pathological conditions].
abstract: The narrow-band action potentials (NAP) and the ordinary electrocochleograms were recorded from the guinea-pig cochlea under normal and pathological conditions in order to study whether the NAP could be a useful measure to detect cochlear dysfunctions. The cochlea damaged either by the administration of kanamycin or by a mechanical lesion of the round window served as pathological materials. Recordings showed that the threshold and amplitude measured for the N1 potential of NAPs ran in parallel with those of the cochlear microphonic potentials (CM), under both normal and pathological conditions of the cochlea. This implies that the CM could be replaced by the NAP when difficulties were present in recording CMs. It may be inferred that the NAP reflects responses of the inner hair-cells and cochlear nerves, while the CM would mainly be derived from responses of the outer hair-cells to the frequency-specific movements of the basilar membrane. If so, the NAP should offer a good means for the objective audiometry. Recording NAPs is also superior to the ordinary electrocochleography in that the method makes it possible to obtain responses generated near the apex of the cochlea, i.e., responses to low-pitch sound stimuli.
authors.affiliation: Department of Physiology, Nagasaki University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Shimamoto
mesh_terms: D000200:Action Potentials; D000818:Animals; D001300:Audiometry, Evoked Response; D003051:Cochlea / Q000502:physiology*; D015834:Cochlear Diseases / Q000503:physiopathology*; D003055:Cochlear Microphonic Potentials; D006168:Guinea Pigs; D012016:Reference Values