title: Myelofibrosis with myeloid metaplasia: clinical and haematological parameters predicting survival in a series of 133 patients.
abstract: The prognostic value of 12 clinical and haematological parameters, recorded at diagnosis, in myelofibrosis with myeloid metaplasia (MMM) was retrospectively analysed in a consecutive series of 133 patients followed for a minimum of 60 months. Multivariate analysis showed that the following features were associated with a significantly shorter survival: (1) short period of time (less than 13 months) between first symptoms and diagnosis; (2) anaemia (haemoglobin less than 10 g/dl); (3) leucocyte count greater than 12 x 10(9)/l; (4) peripheral blood granulocyte precursors greater than 10%. Age, splenectomy and percentage of peripheral blood metamyelocytes were found significantly to affect survival only from univariate analysis, whereas sex, size of spleen, thrombocytopenia and thrombocytosis were of no prognostic significance. These data suggest that a more intensive chemotherapy might be useful for younger patients with bad prognostic factors at diagnosis.
authors.affiliation: Institute of Haematology 'L.eA. Seràgnoli', S. Orsola Hospital, University of Bologna.
authors.forename: G
authors.initials: G
authors.lastname: Visani
authors.forename: C
authors.initials: C
authors.lastname: Finelli
authors.forename: U
authors.initials: U
authors.lastname: Castelli
authors.forename: M C
authors.initials: MC
authors.lastname: Petti
authors.forename: P
authors.initials: P
authors.lastname: Ricci
authors.forename: N
authors.initials: N
authors.lastname: Vianelli
authors.forename: L
authors.initials: L
authors.lastname: Gianni
authors.forename: E
authors.initials: E
authors.lastname: Zuffa
authors.forename: M A
authors.initials: MA
authors.lastname: Aloe Spiriti
authors.forename: R
authors.initials: R
authors.lastname: Latagliata
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006098:Granulocytes / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013156:Splenectomy
chemical_list: D006454:Hemoglobins