[Influence of Mueller-Hinton broth on the in vitro activities of cefuzoname, flomoxef, imipenem, and minocycline against Staphylococcus aureus].
The influence of Mueller-Hinton (MH) broth (from BBL Microbiology Systems, and Difco Laboratories) of minimum inhibitory concentrations (MIC) of cefuzoname (CZON), flomoxef (FMOX), imipenem (IPM), and minocycline (MINO) for 100 strains of Staphylococcus aureus was investigated. Antibacterial activity of MINO was stronger than any other antibiotics. MICs of CZON for 16 strains (14 of 50 methicillin-resistant S. aureus (MRSA), 2 of 50 methicillin-sensitive S. aureus) were greater than or equal to 4-fold greater when tested in BBL MH broth than when tested in Difco MH broth, thus, different media altered categories of some strains (8 of 50 MRSA) from susceptible to resistant. MICs of FMOX in the BBL MH broth for 12 of 50 MRSA strains rose greater than or equal to 4-fold compared to the Difco MH broth. On the other hand, MICs of IPM and MINO were affected very little by the different brand of MH broth used.
Fujita
S
S
Central Clinical Laboratory, Kanazawa University Hospital.
Tonohata
A
A
D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D015378:Imipenem / Q000494:pharmacology*; D008911:Minocycline / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology*
D002511:Cephalosporins; D003470:Culture Media; D013754:Tetracyclines; D015378:Imipenem; C049934:cefuzonam; D015296:Ceftizoxime; D008911:Minocycline; C045693:flomoxef