Effect of dimethylsulphoxide on cysteamine-induced duodenal ulceration in rats.
1. Rats were pretreated with dimethylsulphoxide (DMSO) at concentrations of 2, 4 and 6% v/v in the drinking water for 7 days, then injected with a single subcutaneous dose of cysteamine (28 mg/100 g bodyweight) to induce duodenal ulceration. 2. DMSO reduced, in a dose-dependent manner, the incidence and extent of the ulceration. 3. Mucus duodenal content was not significantly affected by either DMSO or cysteamine treatments.
Ali
B H
BH
Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.
D000818:Animals; D003543:Cysteamine; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D009093:Mucus / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D003543:Cysteamine; D004121:Dimethyl Sulfoxide