title: Association of birdshot retinochoroidopathy and HLA-A29 antigen.
abstract: In 1980 Ryan and Maumenee described a new clinical entity characterized by hypopigmented spots in a typical patterned distribution in association with vitritis and retinal vasculopathy leading to cystoid macular oedema and papilloedema. In a recent study of a large group of European patients (n = 102) with birdshot retinochoroidopathy, the importance of the different clinical manifestations and their diagnostic value were assessed. Data on HLA-A29 typing were obtained in 49 patients with birdshot retinochoroidopathy. We could confirm the high association between HLA-A29 and this disease, as found by Nussenblatt in 1982. In 47 of these patients (95.5%) the HLA-A29 antigen was present. This association is presently the highest HLA class I disease association reported with a relative risk of 224.35.
authors.affiliation: Eye Hospital, Rotterdam, The Netherlands.
authors.forename: G S
authors.initials: GS
authors.lastname: Baarsma
authors.forename: H A
authors.initials: HA
authors.lastname: Priem
authors.forename: A
authors.initials: A
authors.lastname: Kijlstra
mesh_terms: D015862:Choroid Diseases / Q000276:immunology* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D015234:HLA-A Antigens / Q000097:blood*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010641:Phenotype; D012164:Retinal Diseases / Q000276:immunology* / Q000473:pathology; D012307:Risk Factors; D014605:Uveitis / Q000276:immunology
chemical_list: D015234:HLA-A Antigens; C035524:HLA-A29 antigen