title: [Photosensitized formation of singlet oxygen in water solutions of covalent porphyrin-antibody conjugates].
abstract: The effective photogeneration of singlet molecular oxygen (1O2) by porphyrins (coproporphyrin I; 2,4-bi (alpha-methoxyethyl) deuteroporphyrin IX and cyclopanten-coproporphyrin I) conjugated with antibodies (mouse monoclonal IgG and IgM and human gamma-globulin) have been observed with the direct luminescence method of 1O2 detection. Absolute quantum yields of 1O2 formation by the conjugates have been determined. The data suggest that porphyrin-antibody conjugates are promising for the use as drugs in photodynamic tumor treatment.
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Egorov
authors.forename: A A
authors.initials: AA
authors.lastname: Krasnovskiĭ
authors.forename: D B
authors.initials: DB
authors.lastname: Pankovskiĭ
authors.forename: G V
authors.initials: GV
authors.lastname: Ponomarev
authors.forename: A P
authors.initials: AP
authors.lastname: Savitskiĭ
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology* / Q000627:therapeutic use; D053685:Laser Therapy; D051379:Mice; D010100:Oxygen; D010777:Photochemistry; D010778:Photochemotherapy; D011166:Porphyrins / Q000494:pharmacology* / Q000627:therapeutic use; D026082:Singlet Oxygen; D012996:Solutions; D014867:Water
chemical_list: D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D011166:Porphyrins; D012996:Solutions; D014867:Water; D026082:Singlet Oxygen; D010100:Oxygen
vernacular_title: Fotosensibilizirovannoe obrazovanie singletnogo kisloroda v vodnykh rastvorakh kovalenthykh kon''iugatov porfirinov s antitelami.