title: Influence of experimental ischemia on the acoustic organ of guinea pigs in electron microscopic studies.
abstract: The aim of the paper was the histological evaluation of the influence of prolonged irritation or ligation of the vertebral artery on the brain stem and the spiral organs of guinea pigs. Electron microscopic studies of cochlear nuclei and spiral organs of 20 guinea pigs, both sexes, body weight of 250 to 300 g, were performed. By electron microscopic analysis, it was found that a greater lesion of spiral organs is observed in the group B (irritation of the vertebral artery at one side). This mostly concerns the outer hair cells, both the receptor and basic part. Lesion of the spiral organs of guinea pigs in the group C (ligature of the vertebral artery at one side) is only described in the basic part of the outer hair cells and their afferent nerve endings. It seems that the observed lesion is a secondary effect. Primary changes caused by ischemia are mostly observed in the cochlear nuclei.
authors.affiliation: Department of Human Anatomy, Medical Academy, Lódź, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Olszewski
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000473:pathology; D003051:Cochlea / Q000098:blood supply* / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs / Q000033:anatomy & histology*; D006198:Hair Cells, Auditory / Q000098:blood supply / Q000648:ultrastructure; D007511:Ischemia / Q000473:pathology*; D008026:Ligation; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D009925:Organ of Corti / Q000473:pathology / Q000648:ultrastructure; D014711:Vertebral Artery / Q000601:surgery