title: Human leukocyte C1q receptor binds other soluble proteins with collagen domains.
abstract: A receptor binding to the C1q subcomponent of complement has been reported by many workers. In this paper we report for the first time that C1q receptor binds not only to C1q, but also to three other structurally similar ligands, namely mannan binding protein (MBP), conglutinin, and lung surfactant protein (SP-A). All these ligands have been reported to enhance removal of species bound to their globular domain from blood (MBP, conglutinin, C1q) or lung (SP-A) through phagocytosis. One of the possible roles for ligand-receptor binding may be initiation of phagocytosis.
authors.affiliation: Department of Biochemistry, University of Oxford, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Malhotra
authors.forename: S
authors.initials: S
authors.lastname: Thiel
authors.forename: K B
authors.initials: KB
authors.lastname: Reid
authors.forename: R B
authors.initials: RB
authors.lastname: Sim
mesh_terms: D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism*; D003094:Collagen; D037222:Collectins; D003166:Complement Activating Enzymes / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors; D007700:Kinetics; D037102:Lectins; D007962:Leukocytes / Q000276:immunology*; D008024:Ligands; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011485:Protein Binding; D011510:Proteolipids / Q000378:metabolism*; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000378:metabolism*; D011951:Receptors, Complement / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism*
chemical_list: C087299:C1QBP protein, human; D002352:Carrier Proteins; D037222:Collectins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D037102:Lectins; D008024:Ligands; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D011951:Receptors, Complement; D011994:Recombinant Proteins; D012712:Serum Globulins; C032402:complement 1q receptor; C024014:conglutinin; D003094:Collagen; D003166:Complement Activating Enzymes