Synthesis, characterization, and antitumor activity of 1,2-bis(diphenylphosphino) ethane platinum(II) and palladium(II) complexes.
A number of 1,2-bis(diphenylphosphino)ethane monomeric platinum(II) and palladium(II) complexes have been synthesized in light of their potential antitumor activity. The metal center is coordinated with a number of carboxylate anions in the cis-configuration. These complexes have been characterized by elemental analysis, conductivity measurement, and various spectroscopic techniques [IR and 195Pt NMR]. In vivo screening tests for activity of these complexes were performed against the L1210/0 murine leukemia cancer model, but none displayed a significant level of antitumor activity.
Khokhar
A R
AR
Department of Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Xu
Q Y
QY
Siddik
Z H
ZH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010165:Palladium; D010984:Platinum; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D009944:Organoplatinum Compounds; C065001:dichloro 1,2-bis(diphenylphosphino)ethaneplatinum(II); C065000:dichloro-1,2-bis(diphenylphosphino)ethanepalladium(II); D010984:Platinum; D010165:Palladium