Hereditary cerebellar degeneration with downbeat nystagmus. A case and it's treatment.
We present a female patient of 48 years with downbeat nystagmus (DBN), moderate impairment of coordination testing and a family history of cerebellar ataxia. We report that a single 2 mg dose of clonazepam (following Currie & Matsuo) resulted in a virtual disappearance of nystagmus and of the patient's symptom of oscillopsia. This result is interpreted in terms of current models of DBN.
McConnell
H W
HW
Department of Physiology, University of Otago, Dunedin, New Zealand.
Darlington
C L
CL
Smith
P F
PF
Sturge
D L
DL
Thomson
S D
SD
Nukada
H
H
Mair
M W
MW
D002524:Cerebellar Ataxia / Q000150:complications / Q000235:genetics*; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000188:drug therapy / Q000209:etiology*
D002998:Clonazepam