[Transient monocytic skin infiltrate during preleukemic phase of acute myelomonocytic leukemia].
An acute myelomonocytic leukemia presenting transient skin rash during preleukemic phase was described. Following four years of unexplained leukopenia, a generalized exanthema developed and subsequently regressed spontaneously. The skin biopsy and immunohistochemistry revealed monocytic infiltration into the dermis. Twenty-eight months later, the patient became leukemic and died. The skin lesions, however, did not occur after leukemic transformation. Probably transient monocytic skin infiltrate was a symptom of preleukemia, a stem cell neoplasm manifested by functionally abnormal maturation.
Sakai
C
C
Division of Hematology and Chemotherapy, Chiba Cancer Center Hospital.
Takagi
T
T
Oguro
M
M
Suga
M
M
D000368:Aged; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology*; D008297:Male; D009000:Monocytes / Q000473:pathology; D011289:Preleukemia / Q000473:pathology*; D012867:Skin / Q000473:pathology*