title: Type I protein S deficiency and skin necrosis.
abstract: A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.
authors.affiliation: Department of Haematology, Withington Hospital, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Craig
authors.forename: D A
authors.initials: DA
authors.lastname: Taberner
authors.forename: A H
authors.initials: AH
authors.lastname: Fisher
authors.forename: D N
authors.initials: DN
authors.lastname: Foster
authors.forename: J
authors.initials: J
authors.lastname: Mitra
mesh_terms: D000074:Acenocoumarol / Q000009:adverse effects; D000328:Adult; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008297:Male; D009336:Necrosis; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D011486:Protein C / Q000302:isolation & purification; D012867:Skin / Q000473:pathology*; D013924:Thrombophlebitis / Q000188:drug therapy*; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors
chemical_list: D011486:Protein C; D014157:Transcription Factors; D035165:Transcription Factors, General; D035602:Transcriptional Elongation Factors; C018648:transcription factor S-II; D006493:Heparin; D000074:Acenocoumarol