[Therapeutic effect of antioxidant dibunol in experimental alcoholic cardiomyopathy].
Ultrastructure and peroxide metabolism of rat myocardium were studied after alcohol administration and partial inhibition of catalase with amino-triazole. There were obtained morphological pattern of alcoholic cardiomyopathy and activation of lipid peroxidation in myocardium under these experimental conditions. Cardiomyocyte ultrastructure and level of lipid peroxidation were improved after treatment with antioxidant-dibunol in high doses (40 and 100 mg/kg). These data indicate the main role of lipid peroxidation in the pathogenesis of alcoholic cardiomyopathy and possibility of its therapy with antioxidants.
Antonenkov
V D
VD
Tsyplenkova
V G
VG
Vikhert
A M
AM
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002310:Cardiomyopathy, Alcoholic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Lechebnyĭ éffekt antioksidanta dibunola pri éksperimental'noĭ alkogol'noĭ kardiomiopatii.