title: [Production and antineoplastic activity of new asymmetric azines on the rubomycin base].
abstract: New alkulidene hydrazones of rubomycin (daunorubicin) with the linear or branched chain of the carbon atoms were studied: rubomycin 13-(hexylidene-2")-hydrazone, rubomycin 13-(heptylidene-3")-hydrazone and rubomycin 13-(4"-methylpentylidene-2")-hydrazone. Alkylidene hydrazones of the formamidine derivatives were also studied: 13:cyclohexylidene hydrazone of 3'-desamino-3'-dimethylformamidine rubomycin and 13-(5"-oxypentyliden-2") hudrazone of 3'-desamino-3'-dimethylformamidine rubomycin. The latter two alkylidene hydrazones were modified twice. It was found that after a single intravenous administration to tumor-free mice the new substance had the same or lower toxicity as compared to that of rubomycin. Antitumor activity of the substances against lymphosarcoma LIO-I was studied comparatively with that of the initial rubomycin. It was shown that the molecule modification at C-13, as well as simultaneous modification at C-13 and the sugar amino group resulted in lowering of the antitumor activity in comparison to that of the starting rubomycin.
authors.forename: V E
authors.initials: VE
authors.lastname: Tarasova
authors.forename: L A
authors.initials: LA
authors.lastname: Ul'ianova
authors.forename: O I
authors.initials: OI
authors.lastname: Iudina
authors.forename: L E
authors.initials: LE
authors.lastname: Gol'dberg
authors.forename: L S
authors.initials: LS
authors.lastname: Povarov
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: E N
authors.initials: EN
authors.lastname: Bychkova
authors.forename: N G
authors.initials: NG
authors.lastname: Shepelevtseva
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000138:chemical synthesis* / Q000627:therapeutic use; D004338:Drug Combinations; D004339:Drug Compounding; D004354:Drug Screening Assays, Antitumor; D006835:Hydrazones / Q000138:chemical synthesis* / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D051379:Mice; D014586:USSR
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D006835:Hydrazones; D003630:Daunorubicin
vernacular_title: Poluchenie i protivoopukholevaia aktivnost' novykh nesimmetrichnykh azinov na osnove rubomitsina.