title: Two-year results of treatment with methionyl human growth hormone in children with Turner syndrome. Dutch Growth Hormone Working Group.
abstract: Methionyl growth hormone (somatrem) in a daily dosage of 4 IU/m2 body surface area was administered to 16 girls with Turner syndrome. Low dose ethinyl estradiol (0.1 microgram/kg body weight) was added in girls aged 13 years or more. Mean (SD) height velocity increased from 3.4 (0.9) to 7.2 (1.7) and 5.3 (1.3) cm/year in the first and second year, respectively. Bone age advanced 1.8 years over 2 years and predicted adult height was increased. Apart from the occurrence of anti-GH antibodies there were no side effects. In conclusion, somatrem is an efficacious and safe therapy for short stature in Turner syndrome over a period of 2 years. Longer follow-up is needed before conclusions about its effect on final height can be drawn.
authors.affiliation: Department of Paediatrics, University of Utrecht, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Rongen-Westerlaken
authors.forename: M H
authors.initials: MH
authors.lastname: Fokker
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
authors.forename: S M
authors.initials: SM
authors.lastname: De Muinck Keizer-Schrama
authors.forename: B J
authors.initials: BJ
authors.lastname: Otten
authors.forename: W
authors.initials: W
authors.lastname: Oostdijk
authors.forename: H A
authors.initials: HA
authors.lastname: Delemarre van den waal
authors.forename: M H
authors.initials: MH
authors.lastname: Gons
authors.forename: A
authors.initials: A
authors.lastname: Bot
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006728:Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019382:Human Growth Hormone; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014424:Turner Syndrome / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D006728:Hormones; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone