Magnesium deficiency-induced cardiomyopathy: protection by vitamin E.
Syrian male hamsters weighing 80-100g were placed on either a magnesium deficient diet (MgD) or an identical diet supplemented with 100 mmols/Kg MgCl. Animals from each group received vitamin E 10, 15, and 25mg three-week slow release pellets, as subcutaneous implants. The animals were sacrificed after 14 days and their hearts isolated for morphological analysis. H&E stained sections were examined by a computer image analysis system for a morphometric determination of the severity of myocardial injury. Vitamin E significantly (p less than 0.01) reduced both the numerical density and the area fraction of MgD lesions. These data indicate possible free radical participation in the mechanism of injury.
Freedman
A M
AM
Division of Experimental Medicine, George Washington University Medical Center, Washington, DC 20037.
Atrakchi
A H
AH
Cassidy
M M
MM
Weglicki
W B
WB
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006224:Cricetinae; D008275:Magnesium Deficiency / Q000150:complications*; D008297:Male; D008647:Mesocricetus; D009206:Myocardium / Q000473:pathology; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E