Possible participation of calcium-regulating factors in senile dementia in elderly female subjects.
um-related factors were compared in 60 elderly female subjects, who were classified into three groups as nondementia group (n = 18), groups of senile dementia of Alzheimer type (SDAT, n = 22) and of vascular type (VTD, n = 20). The group of SDAT showed significant decrease in serum calcium, and increases in serum parathyroid hormone and urinary Ca, and tendency of decrease in serum 1,25-dihydroxyvitamin D, compared to those of the nondementia group. However, the group of VTD, without showing these features, showed a tendency towards decreased serum calcitonin. These results suggest that Ca and Ca-regulating hormones may play several important and different roles in senile dementia.
Ogihara
T
T
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Miya
K
K
Morimoto
S
S
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000502:physiology; D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D002116:Calcitonin / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D003704:Dementia / Q000378:metabolism / Q000503:physiopathology*; D015140:Dementia, Vascular / Q000378:metabolism; D004872:Ergocalciferols / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism / Q000502:physiology*; D012016:Reference Values
D004872:Ergocalciferols; D010281:Parathyroid Hormone; C003564:1,25-dihydroxyergocalciferol; D002116:Calcitonin; D002118:Calcium