title: Anticardiolipin antibodies are no marker for survived myocardial infarction.
abstract: Antiphospholipid antibodies--both the lupus anticoagulant and anticardiolipin antibodies--are closely associated with arterial and venous thrombosis. In this prospective trial the IgM- and IgG-anticardiolipin antibodies in serum were determined in acute and chronic coronary artery disease. Seventy-four unselected males (34-87 years, mean 60) were included in the study. All patients underwent coronary angiography; infectious and autoimmune diseases were exclusion criteria. Sixteen patients had coronary artery disease (group A), 34 showed coronary stenoses with prior infarction (B), and 14 had survived an acute myocardial infarction (C), whereas 10 patients revealed no significant coronary narrowing (D; controls). The major risk factors were the same for all groups. Neither the IgM- nor the IgG-anticardiolipin antibody levels showed any significant difference in the four groups. The severity of coronary artery disease did not correlate to these antibodies. Furthermore, no correlation was found between elevated anticardiolipin antibodies and thrombocyte levels. Thus, a higher anticardiolipin level does not appear to be a marker for recurrent cardiovascular events.
authors.affiliation: Medizinische Universitätsklinik Graz, Kardiologie, Osterreich.
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: E
authors.initials: E
authors.lastname: Kronberger-Schaffer
authors.forename: H
authors.initials: H
authors.lastname: Brussee
authors.forename: G
authors.initials: G
authors.lastname: Klima
authors.forename: A
authors.initials: A
authors.lastname: Obernosterer
authors.forename: M
authors.initials: M
authors.lastname: Toporsch
authors.forename: J
authors.initials: J
authors.lastname: Dusleag
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D003327:Coronary Disease / Q000175:diagnosis* / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D001323:Autoantibodies; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M