Effects of the new anti-ulcer agent 12-sulfodehydroabietic acid monosodium salt on duodenal alkaline secretion in rats.
Alkaline secretion was measured by pH-stat titration (pH 7.4) during circulation of 0.15 mol/l NaCl through the duodenal lumen in urethane-anesthetized rats. 12-Sulfodehydroabietic acid monosodium salt (TA-2711), at concentrations of 5 and 10 mg/ml, instilled into the circulating fluid at pH 7.4 caused a slight increase in alkaline secretion. When the duodenal lumen was acidified to pH 2.0 for 5 min by instillation of HCl into the circulating fluid, a remarkable increase in alkaline secretion occurred. Addition of TA-2711 (5 and 10 mg/ml) to the circulating fluid considerably enhanced the acid-induced alkaline secretion, with a concurrent increase in prostaglandin E2 release into the circulating fluid. These effects of TA-2711 were inhibited by the pretreatment with indometacin (10 mg/kg s.c.). The results indicate that TA-2711 has an enhancing effect on acid-induced alkaline secretion and endogenous prostaglandins may be involved in the alkaline secretion enhanced by TA-2711.
Onoda
Y
Y
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Magaribuchi
T
T
Tamaki
H
H
D045784:Abietanes; D000468:Alkalies / Q000378:metabolism; D000758:Anesthesia; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D015232:Dinoprostone / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D045784:Abietanes; D000468:Alkalies; D000897:Anti-Ulcer Agents; D004224:Diterpenes; C061681:ecabet; D015232:Dinoprostone; D007213:Indomethacin