title: Interaction of angiotensin II with the cholinergic and noradrenergic systems in the rat pineal gland: regulation of indole metabolism.
abstract: The pineal gland, angiotensin, and noradrenergic and cholinergic systems are involved in the regulation of tissue indole metabolism. Angiotensin II increased noradrenaline release and the production of hydroxy- and methoxyindoles by pineal slices. Electrical field stimulation (EFS) of pineal slices released angiotensin II and reproduced many of the actions of exogenous angiotensin II on serotonin and melatonin biosynthesis and release. Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production. Nadolol blocked both the EFS-induced and the angiotensin II-induced production of melatonin. Atropine and [Sar, Ile]-ANG II did not modify melatonin biosynthesis in electrically stimulated slices, but the muscarinic receptor antagonist increased the stimulatory effect of angiotensin II. These data showed that EFS released angiotensin II and noradrenaline from pineal slices and that a close functional connection exists between the peptide and acetylcholine. The stimulation of serotonin biosynthesis and release by these two neurotransmitters was negatively regulated by noradrenaline acting through beta-adrenergic receptors.
authors.affiliation: Laboratorio de Sustancias Vasoactivas, Universidad de Buenos Aires, Argentina.
authors.forename: L M
authors.initials: LM
authors.lastname: Finocchiaro
authors.forename: D J
authors.initials: DJ
authors.lastname: Goldstein
authors.forename: S
authors.initials: S
authors.lastname: Finkielman
authors.forename: V E
authors.initials: VE
authors.lastname: Nahmod
mesh_terms: D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism; D009248:Nadolol / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
chemical_list: D007211:Indoles; D000804:Angiotensin II; D012701:Serotonin; D009248:Nadolol; D001285:Atropine; D014364:Tryptophan; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D008550:Melatonin; D009638:Norepinephrine