title: Recovery of regional myocardial dysfunction after successful coronary angioplasty early after a non-Q wave myocardial infarction.
abstract: More aggressive therapy has been suggested for patients who have a non-Q wave myocardial infarction (MI) because of the frequency of subsequent unstable angina, recurrent MI, and high mortality rate compared to patients with Q wave MI. The present study was undertaken to investigate the effect of coronary angioplasty on regional myocardial function of the infarct zone in patients with angina early after a non-Q wave MI. The study population consisted of 36 patients undergoing successful coronary angioplasty within 30 days of a non-Q wave MI, in whom sequential left ventricular angiograms of adequate quality were obtained before the initial procedure and at follow-up angiography. The global ejection fraction increased significantly from 60 +/- 9% to 67 +/- 6% (p = 0.0003). This significant increase in the global ejection fraction was primarily due to a significant improvement in the regional myocardial function of the infarct zone. The results of the present study show not only that ischemic attacks early after a non-Q wave MI may lead to prolonged regional myocardial dysfunction but more important that this depressed myocardium has the potential to achieve normal contraction after successful coronary angioplasty.
authors.affiliation: Thoraxcenter, University Hospital Rotterdam, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Suryapranata
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
authors.forename: K
authors.initials: K
authors.lastname: Beatt
authors.forename: P J
authors.initials: PJ
authors.lastname: De Feyter
authors.forename: M
authors.initials: M
authors.lastname: van den Brand
authors.forename: J
authors.initials: J
authors.lastname: Roelandt
mesh_terms: D000792:Angiography; D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013794:Thallium Radioisotopes; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes