Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA.
Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.
Frolova
E I
EI
Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
Ivanova
E M
EM
Zarytova
V F
VF
Abramova
T V
TV
Vlassov
V V
VV
D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D004277:DNA, Single-Stranded; D006418:Heme / Q000031:analogs & derivatives; D006427:Hemin; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010880:Piperidines
D004277:DNA, Single-Stranded; D009838:Oligodeoxyribonucleotides; D010880:Piperidines; D006418:Heme; C032727:piperidine; D006427:Hemin