Effect of latent iron deficiency on the levels of iron, calcium, zinc, copper, manganese, cadmium and lead in liver, kidney and spleen of growing rats.
Feeding a marginally low iron content diet (18-20 mg iron/kg diet) to weaned (21-day-old) rats for 8 weeks produced a significant decrease in liver non-heme iron (66%, p less than 0.001) but no change in blood hemoglobin. Total iron contents of liver (56%, p less than 0.01), spleen (20%, p less than 0.05), and kidney (19%, p less than 0.05) were also found to decrease along with increased zinc, copper, calcium, manganese lead and cadmium in various organs. The magnitude of alteration of a metal was different in different organs. However, liver was found to be the most affected organ. Two weeks of rehabilitation with iron-sufficient diet (390 mg iron/kg diet) normalized these altered levels.
Shukla
A
A
Department of Pediatrics, Banaras Hindu University, Varanasi, India.
Agarwal
K N
KN
Shukla
G S
GS
D000818:Animals; D002104:Cadmium / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D005260:Female; D007501:Iron / Q000378:metabolism; D000090463:Iron Deficiencies; D007668:Kidney / Q000378:metabolism*; D007854:Lead / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008345:Manganese / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D008670:Metals; D002104:Cadmium; D007854:Lead; D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc; D002118:Calcium