Pathway to carcinogenesis: the role of bacteria.
A bacterium is involved in the etiology and physiopathology of the malignant cell. It is not any bacterium, but one with specific characteristics suggestive of a plant-type metabolic and respiratory physiology. Utilizing mice growing sarcomatous lesions as an experimental model, we have been able to recover, in 100% of culture procedures, the Staphylococcus aureus coagulase positive micro-organism, provided that a modified media, as described in a later paragraph, is utilized to sustain these microbes while in transfer from in vivo to in in vitro measures. In human cancer tissue studied, the Ascomycete fungus as well as the Staphylococcus could be isolated (1). Bacteria, fungi, or viruses, isolated by the culturing of cancerous tissue or by their recognition through microscopic study, in itself do not constitute satisfactory reasons to conclude that such microbes are the causative factors in cancer etiology. There must be a definite pathway of bacterial activity to justify such a conclusion. Our experimental studies have defined such a pathway. Of extreme importance is the fact that the Staphylococcus, as a separate entity, does not and cannot produce a malignant cell. Our studies indicate that the malignant cell can only occur in a warm-blooded living animal or human, and it is dependent upon three factors. The bacterium as the first factor must possess characteristics of a plant micro-organism. Specifically, they must have a reducing factor capable of creating an oxygen free millieu in an enclosed area, must be able to convert during duress to a unicellular micro-coccus, and must remain viable within a sac or cell despite the absence of their outside cell wall.(ABSTRACT TRUNCATED AT 250 WORDS)
White
M W
MW
Department of Research, North Detroit General Hospital, Michigan 48212.
D000693:Anaerobiosis; D000818:Animals; D051379:Mice; D008811:Mice, Inbred DBA; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D014048:Tolonium Chloride
D014048:Tolonium Chloride