The effect of ipsapirone on behavioural and cardiac responses in the shock-probe/defensive burying test in male rats.
The effects of the 5-HT1A receptor agonist, ipsapirone, on cardiac and behavioural responses of male Wistar rats in a conditioned defensive burying paradigm for anxiolytics were investigated. The shocked rats displayed defensive burying accompanied by an increase in heart rate. Ipsapirone-treated rats (5 and 10 mg/kg i.p.) showed less burying behaviour than did vehicle-treated controls, and the tachycardiac response was also reduced in a dose-dependent way whereas eating behaviour was facilitated. The results demonstrate the effectiveness of ipsapirone, thereby suggesting the involvement of 5-HT1A receptors in a conditioned anxiety situation that elicits an active coping behaviour and sympathetic activation.
Korte
S M
SM
Department of Animal Physiology, University of Groningen, Haren, The Netherlands.
Bohus
B
B
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004562:Electrocardiography; D004597:Electroshock; D006321:Heart / Q000187:drug effects*; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011743:Pyrimidines; C043077:ipsapirone