[Parietal cell ultrastructure and acid secretory function before and after vagotomy].
Vagotomy was performed in 238 consecutive patients with duodenal ulcer since 1977. Electron microscopy of parietal cells from gastric body mucosa, gastric acid secretory test, and serum gastrin evaluation were done in randomly selected 15 PCV and 13 SV+A cases before and after vagotomy. It was found that 2-6 weeks after the surgery, the ultrastructure of parietal cells presented the feature of secretory depression and gastric acid output was decreased. One to ten years after PCV, the ultrastructure gradually regained its preoperative morphology, serum gastrin level was also increased, though acid output remained on low level. During the same period, patients undergoing SV+A were characterized with the feature of depressed secretion in gastric mucosa ultrastructure, and constantly low level of gastric acid output and serum gastrin. These results, in the authors' belief, may explain low gastric acid output after vagotomy and provide theoretical basis for the application of vagotomy in surgical treatment of duodenal ulcer.
Zou
Z S
ZS
General Hospital of Nanjing, Unit of People's Liberation Army.
D000293:Adolescent; D000328:Adult; D004381:Duodenal Ulcer / Q000473:pathology / Q000601:surgery; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000648:ultrastructure; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000648:ultrastructure*; D014628:Vagotomy / Q000379:methods
D005755:Gastrins