Glutamine derivatives as novel anticancer agents acting via gastrin binding sites.
With regard to the structural analogies between the C-terminal tetrapeptide of gastrin, gastrin receptor antagonists and anticancer derivatives of glutamine, it is plausible to propose that the mechanism of the anticancer activity may be related to interaction with the gastrin receptor. Dietary glutamine intake and glutamine metabolites may also influence the activity of gastrin receptors.
Szkudliński
M
M
Institute of Endocrinology, Medical Academy of Lódź, Poland.
Lewiński
A
A
Rybicka
I
I
Wajs
E
E
Pawlikowski
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001665:Binding Sites; D005755:Gastrins / Q000378:metabolism; D005973:Glutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D011949:Receptors, Cholecystokinin / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005755:Gastrins; D011949:Receptors, Cholecystokinin; D005973:Glutamine