[The serotoninergic mechanism and the experimental therapy of sleep disorders in desynchronization].
The authors studied the dynamics of changes in the serotonin content in the brain of albino rats in development of experimental neurosis along the type of desynchronization and under the effect of essential amino acid L-tryptophan. It was found that disturbance in the sleep-awake cycle in desynchronization is attended with decrease in the serotonin level in the hemispheres and brain stem and leveling out the interhemispheric asymmetry. Injection of 80 mg/kg L-tryptophan in this condition leads to increase of the brain serotonin content and restoration of the normal physiological structure of the sleep-awake cycle.
Gromov
L A
LA
Pishel'
V Ia
VIa
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003344:Cortical Synchronization / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000032:analysis / Q000378:metabolism; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D014364:Tryptophan / Q000627:therapeutic use
D011985:Receptors, Serotonin; D012701:Serotonin; D014364:Tryptophan
Serotoninergicheskiĭ mekhanizm i éksperimental'naia terapiia narusheniĭ sna pri desinkhronoze.