title: A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.
abstract: A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
authors.affiliation: Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Gubbay
authors.forename: J
authors.initials: J
authors.lastname: Collignon
authors.forename: P
authors.initials: P
authors.lastname: Koopman
authors.forename: B
authors.initials: B
authors.lastname: Capel
authors.forename: A
authors.initials: A
authors.lastname: Economou
authors.forename: A
authors.initials: A
authors.lastname: Münsterberg
authors.forename: N
authors.initials: N
authors.lastname: Vivian
authors.forename: P
authors.initials: P
authors.lastname: Goodfellow
authors.forename: R
authors.initials: R
authors.lastname: Lovell-Badge
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012732:Sex Determination Analysis; D013737:Testis / Q000196:embryology* / Q000378:metabolism; D014998:Y Chromosome
chemical_list: D004268:DNA-Binding Proteins