Paradoxical effect of hypothermia on survival of lesioned and uninjured mammalian spinal neurons.
Survival of cultured spinal neurons 2 h after dendrotomy increased significantly when the temperature was reduced to 17 degrees C or 7 degrees C. Survival of lesioned neurons maintained at 17 degrees C for 2 h and then at 37 degrees C for 22 h was still significantly higher than survival of neurons maintained at 37 degrees C for 24 h. Below 17 degrees C both lesioned and uninjured neurons swelled. Upon rewarming to 37 degrees C, many swollen neurons died. Ketamine prevented hypothermic swelling and neuronal death.
Lucas
J H
JH
Department of Biological Sciences, University of North Texas, Denton 76203.
Wang
G F
GF
Gross
G W
GW
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003080:Cold Temperature; D007649:Ketamine / Q000494:pharmacology*; D051379:Mice; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D007649:Ketamine