[The effects and properties of sodium nucleinate as a pyrogen working standard. 8. Pyrogen adsorption to charcoal and plastic].
Not only solutions containing bacterial lipopolysaccharide (P) but also sodium nucleinate (NN) solutions can be made free from pyrogens by treatment with charcoal adsorbing the two pyrogens. When shaking P- and NN-containing solutions with polyethylene granulate, P and NN are also partly adsorbed to this granulate. NN adsorption is smaller than that of P, relative to the determined pyrogenicity of the solutions tested. It could be discussed if this difference could also be interpreted in a way that NN itself and not only a contamination of this substance with lipopolysaccharide is the reason for the pyrogenic effect.
Dressel
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Institut für Arzneimittelwesen DDR, Berlin.
D000327:Adsorption; D000818:Animals; D002606:Charcoal; D009696:Nucleic Acids / Q000032:analysis*; D010969:Plastics; D011749:Pyrogens / Q000032:analysis*; D011817:Rabbits; D012015:Reference Standards
D009696:Nucleic Acids; D010969:Plastics; D011749:Pyrogens; D002606:Charcoal; C013683:sodium nucleinate
Uber Wirkungen und Eigenschaften des als Pyrogen-Arbeitsstandard verwendeten Natriumnucleinats. 8. Mitteilung: Pyrogen-Adsorption durch Kohle und durch Plaste.