Lithium potentiates agonist formation of [3H]CDP-diacylglycerol in human platelets.
Thrombin stimulated a rapid formation of [3H]CDP-diacylglycerol in platelets prelabelled with [3H]cytidine. This response was increased in the presence of LiCl after a delay of 5 min; potentiation could be prevented by myo-inositol. Since Li+ inhibits the liberation of inositol from inositol phosphates, the conversion of diacylglycerol to phosphatidylinositol via CDP-diacylglycerol may be dependent on the regeneration of inositol from this pathway.
Watson
S P
SP
Department of Pharmacology, Oxford, U.K.
Shipman
L
L
Godfrey
P P
PP
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003562:Cytidine / Q000378:metabolism; D003567:Cytidine Diphosphate Diglycerides / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D009702:Nucleoside Diphosphate Sugars / Q000097:blood*; D010716:Phosphatidylinositols / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology
D003567:Cytidine Diphosphate Diglycerides; D009702:Nucleoside Diphosphate Sugars; D010716:Phosphatidylinositols; D007294:Inositol; D003562:Cytidine; D008094:Lithium; D013917:Thrombin