The use of probenecid to increase the serum amoxycillin levels in patients with bronchiectasis.
Amoxycillin 3 g twice daily is effective in treating patients with bronchiectasis who have daily purulent sputum. However, it is a relatively expensive treatment if used for prolonged periods. This pilot study in six patients with bronchiectasis showed that the concurrent administration of probenecid with a smaller dose of amoxycillin produced similar clinical responses and pharmacokinetic profiles to those found with high dose amoxycillin alone. The amount of amoxycillin used was reduced by two thirds, producing a potential saving of approximately pound 1000 per patient per annum in those taking long term treatment.
Allen
M B
MB
City General Hospital, Stoke-on-Trent, Staffs, U.K.
Fitzpatrick
R W
RW
Barratt
A
A
Cole
R B
RB
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001987:Bronchiectasis / Q000188:drug therapy* / Q000378:metabolism; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D000658:Amoxicillin; D011339:Probenecid