Quinaldopeptin, a novel antibiotic of the quinomycin family.
Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage.
Toda
S
S
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
Sugawara
K
K
Nishiyama
Y
Y
Ohbayashi
M
M
Ohkusa
N
N
Yamamoto
H
H
Konishi
M
M
Oki
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D004448:Echinomycin / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011810:Quinoxalines / Q000494:pharmacology*; D013057:Spectrum Analysis; D013306:Streptomycetaceae / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D011810:Quinoxalines; C065444:quinaldopeptin; D004448:Echinomycin