Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of "therapeutic" radon exposure.
A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by "therapeutic" low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18,del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.
Rechavi
G
G
Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel.
Berkowicz
M
M
Rosner
E
E
Neuman
Y
Y
Ben-Bassat
I
I
Ramot
B
B
D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000209:etiology / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D009153:Mutagens; D011829:Radiation Dosage; D011886:Radon / Q000009:adverse effects* / Q000627:therapeutic use; D013166:Spondylitis / Q000532:radiotherapy
D009153:Mutagens; D011886:Radon