title: Validation studies of iodine-123-iodoamphetamine as a cerebral blood flow tracer using emission tomography.
abstract: We studied the radioisotope iodine-123-iodoamphetamine ([123I]IMP) and its performance in single-photon emission computed tomographic (SPECT) studies of cerebral blood flow (CBF). In seven normal volunteers, IMP/SPECT CBF measurements were calculated using a two-compartment model and were compared with the results of CBF measurements utilizing (O15)-H2O and positron emission tomography (PET). Calculated mean PET CBF was 57.6 ml/100 g/min while the SPECT CBF value was 47.3 ml/100 g/min. The response of IMP/SPECT CBF to alterations in arterial PaCO2 was studied in hypo-, eu- and hypercarbic subjects. SPECT CBF values showed a reactivity of 1.03 ml/100 g/min per mmHg PaCO2 change. These results show that the IMP/SPECT CBF technique may be used for quantitative imaging of CBF in man. They provide further support for IMP as a CBF tracer.
authors.affiliation: Department of Neurology, University of Pennsylvania, Philadelphia 19104.
authors.forename: J H
authors.initials: JH
authors.lastname: Greenberg
authors.forename: M
authors.initials: M
authors.lastname: Kushner
authors.forename: M
authors.initials: M
authors.lastname: Rango
authors.forename: A
authors.initials: A
authors.lastname: Alavi
authors.forename: M
authors.initials: M
authors.lastname: Reivich
mesh_terms: D000662:Amphetamines; D002560:Cerebrovascular Circulation; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D012016:Reference Values; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine