Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+.
Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.
Thorin-Trescases
N
N
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.
Oster
L
L
Atkinson
J
J
Capdeville
C
C
D000818:Animals; D001158:Arteries / Q000187:drug effects; D001572:Benzofurans; D002118:Calcium / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D016257:Fura-2; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*
D001572:Benzofurans; D012701:Serotonin; D002118:Calcium; D016257:Fura-2; D009638:Norepinephrine