[An experimental study of the safety of the preparation bonnecor in trials on dogs].
The preclinical study of safety of an antiarrhythmic drug bonnecor (GS-015) was carried out in the experiments on dogs. Administration of the drug in a dose of 5 mg/kg was found to exert no significant effect on functions of the vital organs. The dosage of 15 mg/kg can produce in dogs changes of the hematological and biochemical parameters and cause functional disorders of the cardiac muscle and death of the animals. The data obtained indicate that in dogs the drug possesses a little therapeutic range.
Kovalenko
L P
LP
Sorokina
A V
AV
Popova
G R
GR
Batanova
O A
OA
Liubimov
B I
BI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D001769:Blood / Q000187:drug effects / Q000378:metabolism; D001772:Blood Cell Count / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects; D003984:Dibenzazepines / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008297:Male; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine
Eksperimental'noe izuchenie bezopasnosti preparata bonnekora v oytakh na sobakakh.