Rifampicin-induced upper gastrointestinal bleeding.
Gastrointestinal disturbances like anorexia, nausea, vomiting, abdominal discomfort and diarrhoea are known adverse effects of rifampicin. We report an upper gastrointestinal bleeding due to haemorrhagic gastric erosions after ingestion of rifampicin for pulmonary tuberculosis. The cause and effect relationship between development of haemorrhagic gastric erosions and rifampicin administration was confirmed by rechallenge with rifampicin. To our knowledge no such adverse effect of rifampicin has been reported previously.
Zargar
S A
SA
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Thapa
B R
BR
Sahni
A
A
Mehta
S
S
D002648:Child; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D012293:Rifampin