[Penetration of antibiotics into the vitreous humor in man].
Using newly invented method for collecting vitreous samples, we examined the permeability of antibiotics across the blood-ocular barrior in human eyes. One of the advantages of the present method is that it yields sufficient amounts of sample. This makes it possible to examine and compare the permeability of multiple drugs with the same sample. We studied two antibiotics, Flomoxef Sodium (FMOX) and Cefamandole Sodium (CMD) with proliferative vitreoretinopathy (8 cases), proliferative diabetica retinopathy (8 cases) and simple vitreous haemorrhage (9 cases: including 3 cases of Terson's syndrome). A considerable amount of FMOX was detected in the vitreous sample and the permeability of FMOX was 50% better than that of CMD. Permeability also differed recording of different ocular diseases. The amount of the drug was lowest in cases with simple vitreous hemorrhage, especially in Terson's syndrome (p less than 0.05). This is reasonable as the blood-ocular barrior must be less disturbed in this disease than the other two conditions.
Tamai
M
M
Dept. of Ophthalmol., Tohoku Univ., School of Med., Sendai, Japan.
Abe
T
T
D000328:Adult; D000368:Aged; D002435:Cefamandole / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D003930:Diabetic Retinopathy / Q000378:metabolism; D005128:Eye Diseases / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*
D002511:Cephalosporins; D002435:Cefamandole; C045693:flomoxef