title: Simultaneous determination of dextropropoxyphene, norpropoxyphene and methaqualone in plasma by gas chromatography with selective nitrogen detection.
abstract: A method for the identification and quantification of dextropropoxyphene, norpropoxyphene, and methaqualone in plasma by GC/NPD is presented. The procedure employs cyclizine as the internal standard and requires no derivatization. After a single-step extraction, analysis is achieved in 8 min. The lower limits of detection were found to be 6, 12, and 1 ng/ml for dextropropoxyphene, norpropoxyphene, and methaqualone, respectively. This method appears to be rapid, sensitive, and applicable to forensic and clinical toxicological analyses.
authors.affiliation: Institut de Médecine Légale, Strasbourg.
authors.forename: P
authors.initials: P
authors.lastname: Kintz
authors.forename: A
authors.initials: A
authors.lastname: Tracqui
authors.forename: P
authors.initials: P
authors.lastname: Mangin
authors.forename: A A
authors.initials: AA
authors.lastname: Lugnier
authors.forename: A A
authors.initials: AA
authors.lastname: Chaumont
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D011431:Dextropropoxyphene / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D008702:Methaqualone / Q000097:blood*; D008832:Microchemistry
chemical_list: D008702:Methaqualone; C002756:norpropoxyphene; D011431:Dextropropoxyphene