Human equivalent doses of platelet inhibitors and experimental atherosclerosis.
The effects of aspirin, dipyridamole and sulfinpyrazone on the development of atherosclerotic lesions in the aorta were studied in cholesterol-fed rabbits. Aspirin and sulfinpyrazone prevented the development of atherosclerosis, whereas dipyridamole-treated animals developed advanced atherosclerotic lesions. As all the three drugs inhibit platelet function, some non-platelet effects are probably responsible for the differences in results. It is felt that dipyridamole should be avoided in hypercholesterolemic individuals.
Mittal
S R
SR
Department of Medicine (Cardiology), J.L.N. Medical College and Hospital, Ajmer (Rajasthan), India.
Mathur
A K
AK
Tandon
R
R
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001161:Arteriosclerosis / Q000517:prevention & control*; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D011817:Rabbits; D013442:Sulfinpyrazone / Q000008:administration & dosage / Q000494:pharmacology*
D004176:Dipyridamole; D001241:Aspirin; D013442:Sulfinpyrazone