Immunochemotherapy (thymostimulin/cyclophosphamide) in dogs.
This article demonstrates the positive effect of thymostimulin (TP-1) on leucolymphopoiesis in dogs, based on its apparent ability to counteract the immunodepression induced by cyclophosphamide chemotherapy. Thymostimulin administered to healthy cyclophosphamide-treated dogs prevented the initial drop in the values of leucocytes and lymphocytes due to the chemotherapy and restored these values to the higher levels existing before the treatment. In a control group given a placebo instead of TP-1, the immune depression provoked by cyclophosphamide was maintained during all the therapeutic cycles.
Montoya
J A
JA
Dpto. de Patología Animal, Facultad de Veterinaria, Madrid, Spain.
Martínez
E M
EM
Rodríguez
M
M
Pérez-Cuadrado
S
S
D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D013949:Thymus Extracts / Q000627:therapeutic use*
D013949:Thymus Extracts; C031407:thymostimulin; D003520:Cyclophosphamide