title: Evidence of a rare gene for low systolic blood pressure in the Framingham Heart Study.
abstract: A major risk factor for coronary heart disease in both men and women is elevated systolic blood pressure (SBP). We performed segregation analysis on age, sex-adjusted, and transformed systolic blood pressure data on 1,141 families from the Framingham cohort-offspring study using the segregation analysis program POINTER. The results of hypothesis testing revealed: (1) these data are consistent with familial transmission; (2) there is evidence for the transmission of a rare, major gene for low SBP with a gene frequency of q = 0.02; and (3) most of the transmissible component to SBP can be attributed to the polygenic background with H = 0.31.
authors.affiliation: Clinical and Genetic Epidemiology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Md.
authors.forename: C L
authors.initials: CL
authors.lastname: Carter
authors.forename: W B
authors.initials: WB
authors.lastname: Kannel
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure / Q000235:genetics*; D015331:Cohort Studies; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008404:Massachusetts; D008875:Middle Aged; D012044:Regression Analysis; D012737:Sex Factors; D013599:Systole