Cartilage resurfacing of the rabbit knee. The use of an allogeneic demineralized bone matrix-autogeneic perichondrium composite implant.
A full-thickness articular-cartilage defect was created in the medial femoral condyles of 32 adult rabbits. The defects were filled with demineralized bone or a composite of demineralized bone and perichondrium. Results of cartilage repair were assessed after 12 weeks of implantation. We conclude that demineralized bone matrix used as a subchondral matrix in a cartilage repair model 1) stimulates and induces subchondral bone ingrowth, 2) provides a surface on which cartilage repair can proceed, and 3) can be utilized as a platform on which perichondrium can be fixed to provide a cellular source for cartilage repair. Repair tissue that developed from perichondrium was thicker, more closely resembled normal articular cartilage, and was of a less fibrous nature than the repair tissue that developed de novo on the demineralized bone matrix.
Billings
E
E
Malcolm and Dorothy Coutts Institute for Joint Reconstruction and Research, San Diego CA 92123.
von Schroeder
H P
HP
Mai
M T
MT
Aratow
M
M
Amiel
D
D
Woo
S L
SL
Coutts
R D
RD
D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D002113:Calcification, Physiologic; D002356:Cartilage / Q000033:anatomy & histology / Q000601:surgery*; D003238:Connective Tissue / Q000637:transplantation*; D007719:Knee Joint / Q000033:anatomy & histology / Q000601:surgery*; D011817:Rabbits; D014184:Transplantation, Homologous / Q000379:methods