DNA demethylation in erythroleukaemia cells.
Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30-50% and this may be a contributory cause of the observed fall in CG methylation.
Adams
R L
RL
Department of Biochemistry, University of Glasgow, UK.
Hanley
A
A
Rinaldi
A
A
D000818:Animals; D001482:Base Composition; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism*; D015257:DNA-Cytosine Methylases / Q000378:metabolism; D004920:Erythropoiesis; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism*; D008745:Methylation; D051379:Mice; D014407:Tumor Cells, Cultured
D004247:DNA; D015257:DNA-Cytosine Methylases