Determination of macrophage chemotaxis to atherosclerotic plaque extract in domestic turkeys with hypertension.
The chemotactic activity of turkey peritoneal macrophages in response to an atherosclerotic plaque extract from a hypertensive strain of turkeys was determined. Atherosclerotic plaque extract stimulated macrophage chemotaxis, whereas normal aortic extract did not stimulate macrophage chemotaxis. However, differences were not revealed by sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of extracts of atherosclerotic plaque and normal aorta. Chemotactic activity was diminished with pronase treatment, suggesting the chemo-attractant is a protein. Seemingly, atherosclerotic plaque of turkeys contains a macrophage chemotaxin.
Johnson
P D
PD
Department of Anatomy and Histology, College of Veterinary Medicine, Auburn University 36849.
Klesius
P H
PH
Krista
L M
LM
D000818:Animals; D001018:Aortic Diseases / Q000209:etiology / Q000662:veterinary*; D001161:Arteriosclerosis / Q000209:etiology / Q000662:veterinary*; D002630:Chemotactic Factors / Q000032:analysis*; D002634:Chemotaxis, Leukocyte; D006973:Hypertension / Q000662:veterinary*; D008264:Macrophages; D008297:Male; D011201:Poultry Diseases / Q000209:etiology*; D014422:Turkeys
D002630:Chemotactic Factors