title: Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata.
abstract: A new sesquiterpene pyridine alkaloid, emarginatine B [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine B showed potent cytotoxicity against human KB cells (ED50 = 0.4 micrograms/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill.
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: L M
authors.initials: LM
authors.lastname: Kuo
authors.forename: M L
authors.initials: ML
authors.lastname: King
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Haruna
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D008453:Maytansine / Q000302:isolation & purification; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C064682:emarginatine A; C064681:emarginatine B; D008453:Maytansine