[An evaluation of urinary Tamm-Horsfall protein coating cell in the diagnosis of urologic neoplasms].
By utilizing enzymic immunoassay, in a total of 161 cases of urologic tumors, Tamm-Horsfall Protein Coating Cells (THPC) could be found uniquely in the urines of renal tumors, whereas was absent in those of normal control as well as in the urines of transitional cell carcinomas of pelvis, ureter and bladder. Renal cell carcinoma predominated over in the THPC positive cases, among which granular cell carcinoma demonstrated a higher positive rate than that of clear cell type, 40% versus 15%. THP antigen could be found in the 66.6% frozen sections of renal cell carcinoma and the THP concentration in urine were also higher. Therefore, the detection of THP coating cells in urine of urologic neoplasm may be useful in evaluating the renal origin of the exfoliated tumor cells and elevating the screening accuracy of renal cell carcinoma, with no harms to the patients and no special equipment.
Cai
B J
BJ
Institute of Urology, Beijing Medical University.
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin