Daily changes in pentylenetetrazol-induced convulsions and open-field behavior in rats.
Susceptibility to pentylenetetrazol (PTZ)-induced clonic convulsions was measured in rats over the 24-hr light-dark cycle at four-hour intervals. The results showed a higher sensitivity to PTZ around 2200 hr. Other groups of rats were exposed to a four-min open-field session. In the first two min of the session the animals were submitted to open-field environmental stimuli. The next two-min observation occurred with sound and light presented to the animals. Differences through the 24-hr period of the day for both sessions were seen. A reduction in rearing at 2200 hr and increase in defecation at 2200 hr and 0200 hr was observed.
Eidman
D S
DS
Departamento de Psicobiologia, Escola Paulista de Medicina, Sao Paulo Brasil.
Benedito
M A
MA
Leite
J R
JR
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*; D012931:Social Environment
D010433:Pentylenetetrazole