title: The pharmacoeconomics of renal transplantation: increased drug costs with decreased hospitalization costs.
abstract: We evaluated the economic and clinical effects of two immunosuppressive drug regimens used to treat recipients of human leukocyte antigen (HLA)-identical sibling donor renal transplants during the first posttransplant year. We compared consecutive patients in two groups of 30 who were given either antilymphoblast globulin (ALG), azathioprine, plus prednisone or cyclosporine, azathioprine, and prednisone for immunosuppression. We standardized all dollar values, costs and charges, to the 1986 level using our hospital's health care charge inflation rate. There were no significant differences between the two treatment groups for actual patient (100% vs 93%; p = 0.51) and graft survival rates (100% vs 93%; p = 0.51), average serum creatinine level (1.0 +/- 0.3 vs 1.0 +/- 0.2 mg%; p = 0.46), and most recent creatinine level (1.4 +/- 0.3 vs 1.4 +/- 0.7 mg%; p = 0.45). The average cyclosporine-azathioprine-prednisone costs were $3987/patient more for the first year of therapy than for ALG-azathioprine-prednisone. However, the former regimen produced an average of $9543/patient less in total hospitalization charges. This was due to both a shorter initial hospital stay and a decreased rate of rehospitalization, with a lower frequency of acute rejection episodes (p = 0.001) and infectious complications (p = 0.05). We conclude that, although this cyclosporine-containing protocol was associated with increased drug costs, it is justified by decreased hospitalization charges that resulted from improved efficacy and safety.
authors.affiliation: Department of Pharmacy Practice, School of Medicine, University of Minnesota, MN 55455.
authors.forename: D M
authors.initials: DM
authors.lastname: Canafax
authors.forename: S A
authors.initials: SA
authors.lastname: Gruber
authors.forename: G L
authors.initials: GL
authors.lastname: Chan
authors.forename: C J
authors.initials: CJ
authors.lastname: Miles
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: J S
authors.initials: JS
authors.lastname: Najarian
authors.forename: R J
authors.initials: RJ
authors.lastname: Cipolle
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D003361:Cost Allocation / Q000191:economics; D003524:Cyclosporins / Q000627:therapeutic use; D006680:HLA Antigens / Q000008:administration & dosage; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000191:economics*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D003524:Cyclosporins; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone