[Procollagen-III-peptide in bronchoalveolar lavage fluid as an index of fibrosis in sarcoidosis and idiopathic lung fibrosis?].
In order to answer the question whether in sarcoidosis and idiopathic pulmonary fibrosis there is a relationship between the activity of alveolitis (T4/T8 ratio in sarcoidosis, number of granulocytes in idiopathic pulmonary fibrosis) and the activity of connective tissue formation (type III procollagen peptide in the BAL fluid) BAL was performed in 12 healthy subjects, 33 patients with type II sarcoidosis, and 26 patients with idiopathic pulmonary fibrosis. In the unconcentrated BAL fluid of the healthy subjects, P3P was not measurable. On the basis of the T4/T8 ratio and P3P in type II sarcoidosis, three groups of patients with possibly different risks of progression were found: 1) T4/T8 normal and P3P not or only mildly elevated, 2) T4/T8 elevated and P3P normal or only mildly elevated, 3) T4/T8 elevated and P3P greatly increased. In patients with idiopathic pulmonary fibrosis, the concentration of P3P correlated significantly with the number of granulocytes and the clinical activity parameters. On the basis of these results, we conclude that P3P levels in the BAL fluid, as a direct measure of connective tissue neogenesis, may be a valuable addition to cellular and immunocytological BAL findings.
Teschler
H
H
Ruhrlandklinik Essen-Heidhausen und Abteilung für Pneumologie der Medizinischen Universitätsklinik Freiburg.
Costabel
U
U
Ziesche
R
R
Freitag
L
L
Matthys
H
H
Konietzko
N
N
D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis* / Q000166:cytology; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000175:diagnosis*; D010446:Peptide Fragments / Q000032:analysis*; D011347:Procollagen / Q000032:analysis*; D011658:Pulmonary Fibrosis / Q000175:diagnosis*; D011863:Radioimmunoassay; D012507:Sarcoidosis / Q000175:diagnosis*
D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide
Prokollagen-III-Peptide in der BAL-Flüssigkeit als Fibroseindex bei Sarkoidose und idiopathischer Lungenfibrose?