Fish-oil concentrate: effects on variables related to cardiovascular disease.
Sixty-four male, healthy volunteers aged 35-45 y were randomly assigned to receive (as 1-g capsules) either 14 g fish-oil concentrate/d (55% n-3 fatty acids) or 14 g olive oil/d for 6 wk. Plasma fibrinogen was reduced by 13% and serum triglycerides by 22% after fish-oil supplementation ended. Three weeks after supplementation ended both variables were back to baseline values. An appreciable increase in the ratio of eicosapentaenoic acid to arachidonic acid (EPA:AA) in plasma eicosapentaenoic acid to arachidonic acid (EPA:AA) in plasma and red blood cell phospholipids occurred during the fish-oil intake. High-density-lipoprotein (HDL) cholesterol and HDL2 activity tended to be lowered by fish-oil supplementation. Systolic and diastolic blood pressures, serum cholesterol, gamma-glutamyltransferase, blood glucose, and monocyte low-density-lipoprotein receptor activity did not differ significantly between the two groups. The reduction in plasma fibrinogen concentration seems of special interest because this variable in several recent studies emerges as a separate cardiovascular risk factor with a high predictive value.
Flaten
H
H
Occupational Health Office, Oslo Transport, Norway.
Høstmark
A T
AT
Kierulf
P
P
Lystad
E
E
Trygg
K
K
Bjerkedal
T
T
Osland
A
A
D000328:Adult; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D004435:Eating; D004912:Erythrocytes / Q000032:analysis; D005227:Fatty Acids / Q000097:blood; D005340:Fibrinogen / Q000032:analysis*; D005395:Fish Oils / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood; D011897:Random Allocation; D011973:Receptors, LDL / Q000032:analysis; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D005395:Fish Oils; D010743:Phospholipids; D011973:Receptors, LDL; D014280:Triglycerides; D005340:Fibrinogen