[Comparison of 24-hour gastric pH in normal controls and patients with duodenal ulcer or atrophic gastritis].
Twenty-four intragastric acidity was measured by continuous recording using intragastric glass electrodes in 16 normal controls, 18 inactive duodenal ulcer patients and 7 patients with atrophic gastritis. Median pH for the 24 h period, for the 8 AM-8 PM period, and for the 8 PM-8 AM period were significantly lower in duodenal ulcer patients than in controls (1.19 vs 1.78; 1.17 vs 2.05; 1.27 vs 1.64). Median pH for these 3 periods were significantly higher in patients with atrophic gastritis than in controls (3.90; 3.72; 3.81). The median pH for the 24 h period was higher than the lower quartile value of the control group in 33 per cent of duodenal ulcer patients. During the night (24 h-3 h), duodenal ulcer patients had significantly lower median pH (1.03) than controls (1.51). Antisecretory treatment should be directed to decrease this period of unbuffered acidity.
Pestiaux
A
A
Département Universitaire de Gastroentérologie, Université Libre de Bruxelles, Hôpital Civil de Charleroi, Belgique.
Ooghe
P
P
Van Cauter
J
J
Henry
J P
JP
Ligny
G
G
D000328:Adult; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism; D005756:Gastritis / Q000503:physiopathology*; D005757:Gastritis, Atrophic / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012907:Smoking; D013997:Time Factors
Comparaison du pH gastrique de 24 heures chez des témoins, des ulcéreux duodénaux et des malades atteints de gastrite atrophique.