[Potential cardiotonics. 7. Synthesis and cardiovascular effects of 5-(4-pyridinyl)-, 6-methyl-4-(4-pyridinyl) and 6-methyl-5-phenyl-substituted 3-cyano-2-aminoalkylamino-pyridines].
The title compounds were synthesized by treating of 2-chloro-pyridines 1-3 with the appropriate aminoalkylamines or piperazines. In isolated guinea pig atria some compounds showed greater positive inotropic activity than amrinone. Heart rate was decreased or remained unchanged. In anesthetized dogs some derivatives exerted a dose-dependent increase in myocardial contractility and, additionally, a decrease in blood pressure.
Hagen
V
V
Akademie der Wissenschaften, DDR.
Rumler
A
A
Klauschenz
E
E
Hagen
A
A
Heer
S
S
Faust
G
G
Mitzner
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D002316:Cardiotonic Agents; D003959:Diamines; D009570:Nitriles; D011725:Pyridines
Potentielle Kardiotonika. 7. Mitteilung5: Darstellung und kardiovaskuläre Eigenschaften von 5-(pyrid-4-yl)-, 6-methyl-5-(pyrid-4-yl)- und 6-methyl-5-phenyl-substituierten 2-Aminoalkylamino-3-cyan-pyridinen.