[Evaluation of accelerated development of stable alcoholic motivation in rats for studying potential alcohol deterrents].
The express technique reflecting an acquisition of a clear alcohol addiction during short-term voluntary alcoholization for further antialcoholic drugs testing was performed in male albino rats. By VARIMAX factor analysis of indexes related with preference of alcohol solutions with different tastes the conditions of short-term (2 months) voluntary alcoholization leading to persistent ethanol intake were studied. Isolation stress inducing a specific alcohol drive was excluded from rearing conditions. 0.1% saccharin solution in 15% ethanol was used for alcoholization. Statistical analysis revealed factor of "developed alcohol abuse" which may be detected in conditions of one-trail sweet ethanol intake after 3 days alcohol deprivation (similar to heavy drinking syndrome in humans). Using pharmacological drugs (pyrazidol, piracetam) validity of the method for specific drug design was confirmed.
Salimov
R M
RM
Viglinskaia
I V
IV
D000427:Alcohol Deterrents; D000428:Alcohol Drinking / Q000187:drug effects / Q000523:psychology*; D000437:Alcoholism / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology; D000818:Animals; D002227:Carbazoles / Q000627:therapeutic use; D000431:Ethanol / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D008297:Male; D009042:Motivation; D010889:Piracetam / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D000427:Alcohol Deterrents; D002227:Carbazoles; D000431:Ethanol; C009830:pirlindole; D010889:Piracetam
Otsenka uskorennogo razvitiia ustoĭchivoĭ alkogol'noĭ motivatsii u krys s tsel'iu izucheniia potentsial'nykh protivoalkogol'nykh sredstv.