title: In vivo and in vitro inhibition of platelet aggregation by SV-IV, a major protein secreted from the rat seminal vesicle epithelium.
abstract: In summary, the present study documents that platelet aggregation triggered by thrombin, ADP, collagen and PAF both in vivo and in vitro, was prevented by SV-IV in a dose-dependent manner. Only platelet aggregation by AA was not affected by the protein, thus suggesting a possible involvement of PLA2 inhibition in the molecular mechanism at the basis of SV-IV anti-thrombotic effect.
authors.affiliation: Department of Experimental Pharmacology, University of Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Persico
authors.forename: F
authors.initials: F
authors.lastname: Mancuso
authors.forename: S
authors.initials: S
authors.lastname: Metafora
authors.forename: G
authors.initials: G
authors.lastname: Peluso
authors.forename: G
authors.initials: G
authors.lastname: Ravagnan
authors.forename: C
authors.initials: C
authors.lastname: Esposito
authors.forename: R
authors.initials: R
authors.lastname: Porta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D029589:Seminal Plasma Proteins; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D003094:Collagen; D013917:Thrombin