title: Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue.
abstract: Numerical chromosome aberrations are common in several types of malignant tumors. Recently, trisomy 7 and loss of the Y chromosome were described in cultures from nonneoplastic tissue, making the significance of these aberrations as cancer-associated changes doubtful. We herein report the mosaic occurrence of trisomy 7 in four consecutive short-term cultures initiated from normal kidney tissue. Smaller clones with trisomy 10 were present in three cases, and the only culture established from a male also showed mosaic loss of the Y chromosome.
authors.affiliation: Department of Urology, University Hospital, Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Elfving
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: R
authors.initials: R
authors.lastname: Lundgren
authors.forename: J
authors.initials: J
authors.lastname: Limon
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D007668:Kidney / Q000166:cytology; D008297:Male; D014314:Trisomy; D014998:Y Chromosome
chemical_list: D014408:Biomarkers, Tumor