title: [An early clinical study of Z-100 in leukopenia caused by radiotherapy].
abstract: The clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated in an early clinical study using three doses, 2, 10 and 20 micrograms. According to the evaluation by investigators and time-course of WBC, the highest effective rate was achieved by 20 micrograms. Adverse reactions occurred in all groups, but there were no serious or clinically relevant reactions. These results suggested that Z-100 is clinically useful for the treatment of leukopenia caused by radiotherapy.
authors.affiliation: Department of Radiology, School of Medicine, Keio University.
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: S
authors.initials: S
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Ohkawa
authors.forename: S
authors.initials: S
authors.lastname: Amino
authors.forename: J
authors.initials: J
authors.lastname: Horiuchi
authors.forename: R
authors.initials: R
authors.lastname: Kamata
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takekawa
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000188:drug therapy* / Q000209:etiology; D008055:Lipids / Q000627:therapeutic use*; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D008351:Mannans; C031208:specific substance maruyama