A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.
Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5'-amino-5'-deoxy-5,6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings.
Yoshida
M
M
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Ezaki
M
M
Hashimoto
M
M
Yamashita
M
M
Shigematsu
N
N
Okuhara
M
M
Kohsaka
M
M
Horikoshi
K
K
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D003521:Cyclopropanes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D009705:Nucleosides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013306:Streptomycetaceae / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure
D000935:Antifungal Agents; D003521:Cyclopropanes; D009705:Nucleosides; C065437:FR 900848