Pharmacologic doses of ascorbic acid prolong the effects of pentobarbital anesthesia.
Saline or ascorbic acid (AA), 1000 mg/kg and 1400 mg/kg was administered intraperitoneally (IP) to 3 groups of female Swiss-Webster mice after they had been anesthetized with sodium pentobarbital (SP). Both doses of AA given IP after SP anesthesia significantly prolonged sleeping time. An additional 50 mice were injected IP with 0.3 ml SP containing 6 mg/ml unlabeled SP and 0.6 ng C14 labeled SP. Immediately 25 mice received 40 mg AA in 0.4 ml saline, IP, and the remainder received saline. The serum half life of the radioactively labeled SP was more than 3 times longer in AA treated mice than in the controls.
Hollinshead
M B
MB
Department of Anatomy, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2757.
Spillert
C R
CR
Flynn
E J
EJ
Lazaro
E J
EJ
D000758:Anesthesia; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006207:Half-Life; D007274:Injections, Intraperitoneal; D051379:Mice; D010424:Pentobarbital / Q000097:blood; D012890:Sleep / Q000187:drug effects
D010424:Pentobarbital; D001205:Ascorbic Acid