title: Synthesis and estrogen activity screening of some new D-secoestrone derivatives.
abstract: Five new D-secoestrone derivatives were synthesized, starting from 3-methoxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile. Newly synthesized compounds showed a complete loss of estrogenic activity.
authors.affiliation: Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
authors.forename: J A
authors.initials: JA
authors.lastname: Petrović
authors.forename: V M
authors.initials: VM
authors.lastname: Pejanović
authors.forename: D A
authors.initials: DA
authors.lastname: Miljković
authors.forename: J T
authors.initials: JT
authors.lastname: Hranisavljević
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012632:Secosteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects / Q000254:growth & development
chemical_list: D004967:Estrogens; D012632:Secosteroids; D004970:Estrone