Cord blood red-cell enzymes and reduced glutathione in Indian neonates, normal and with pathologic jaundice.
Red-cell enzymes and reduced glutathione (GSH) were assayed on cord blood in 307 Indian neonates. On follow-up, 20 of them developed pathologic jaundice. Of these, six had red-cell enzyme/GSH deficiency, seven had associated non-enzymatic causes of jaundice, and in the remaining seven the cause could not be diagnosed. In 41 other neonates, there was enzyme/GSH deficiency without pathologic jaundice. The degree of enzyme deficiency had no relation with jaundice. Red-cell enzyme/GSH deficiency state in neonates was associated with pathologic jaundice more frequently (six of 47; 12.8%) than in the absence of such deficiency (14 of 260; 5.4%). None of the jaundiced patients had very high levels of bilirubin nor needed exchange blood transfusion. There was no reduction in haemoglobin level in the enzyme/GSH deficient group with jaundice in comparison with non-deficient jaundiced neonates or normal subjects. The incidence of red-cell enzyme/GSH deficiency appears to be high in Indian neonates; however, the majority of them do not precipitate pathologic jaundice.
Pati
H P
HP
Department of Haematology, All-India Institute of Medical Sciences, New Delhi.
Singh
M
M
Paul
V K
VK
Gupta
R K
RK
Saraya
A K
AK
D000704:Analysis of Variance; D001663:Bilirubin / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D005312:Fetal Blood / Q000032:analysis / Q000201:enzymology*; D005500:Follow-Up Studies; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D005978:Glutathione / Q000032:analysis* / Q000172:deficiency; D005979:Glutathione Peroxidase / Q000032:analysis / Q000172:deficiency; D005980:Glutathione Reductase / Q000032:analysis / Q000172:deficiency; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood*; D010084:Oxidation-Reduction; D010734:Phosphogluconate Dehydrogenase / Q000032:analysis / Q000172:deficiency
D006454:Hemoglobins; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D001663:Bilirubin