[The prophylactic and therapeutic use of piracetam in reproduced myocardial infarct].
The effect of piracetam on the dynamics of the infarction development, free radical lipid peroxidation in the myocardium and the immunological reactivity was studied on dogs with experimental myocardial infarction during the course and prophylactic treatment. The antiarrhythmic, antihypoxic, antioxidant effects of the drug, its positive influence on the parameters of humoral and cellular immunity were revealed. The comparative assessment of piracetam action during cardiogenic stress caused by myocardial infarction showed a higher pharmacological effect in therapeutic use.
Kresiun
V I
VI
Kravchenko
L S
LS
Kadyrova
L L
LL
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D009203:Myocardial Infarction / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D011760:Pyrrolidinones; D010889:Piracetam
Profilakticheskoe i terapevticheskoe primenenie piratsetama pri vosproizvedennom infarkte miokarda.