title: A defasciculating dose of d-tubocurarine causes resistance to succinylcholine.
abstract: Forty-four patients, ASA physical status I or II, undergoing thiamylal, fentanyl, N2O/O2 anaesthesia were studied to determine the dose-response to succinylcholine (Sch) without prior defasciculation (24 pt - Group 1), or three minutes following d-tubocurarine (dTC), 0.043 mg.kg-1 (20 pt - Group 2). The individual log dose-logit response curve for each patient was determined using a cumulative dose plus infusion technique and integrated EMG monitoring of the first dorsal interosseous muscle. The mean (+/- SEM) ED50, ED90 and ED95 values for Sch in Group 1 were 0.13 +/- 0.01, 0.19 +/- 0.01 and 0.22 +- 0.01 mg.kg-1, and in Group 2 were 0.16 +/- 0.01, 0.25 +/- 0.01 and 0.29 +/- 0.02 mg.kg-1, respectively. The mean ED values in Group 2 were significantly greater than the equivalent values in Group 1 (P less than 0.05). Compared with values in Group 1, ED values in Group 2 represented mean increases of 23, 32, and 32 per cent, respectively. These pharmacodynamic data indicate that the dose of Sch needs to be increased by 32 per cent following a defasciculating dose of dTC 3 mg.70 kg-1 (0.043 mg.kg-1).
authors.affiliation: Department of Anesthesiology, Mount Sinai School of Medicine, City University of New York.
authors.forename: J B
authors.initials: JB
authors.lastname: Eisenkraft
authors.forename: M L
authors.initials: ML
authors.lastname: Mingus
authors.forename: A
authors.initials: A
authors.lastname: Herlich
authors.forename: W J
authors.initials: WJ
authors.lastname: Book
authors.forename: A F
authors.initials: AF
authors.lastname: Kopman
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005207:Fasciculation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013390:Succinylcholine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D014403:Tubocurarine / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D013390:Succinylcholine; D014403:Tubocurarine