title: Flow cytometric analysis of DNA content in laryngeal cancer.
abstract: DNA content was measured by flow-cytometric analysis in 30 paraffin embedded sections from patients with laryngeal squamous cell carcinoma. The morphological characteristics and N staging of the tumours as registered in their clinical charts were correlated with their DNA content. Eighty per cent of the tumours were found to have a predominantly aneuploid distribution of DNA values. There was no correlation between the N stage of the tumour or degree of cell differentiation and DNA content. A multiploid pattern correlates with non-metastatic laryngeal tumours and we suggest that this pattern may be a good indicator for biological activity.
authors.affiliation: Department of Otolaryngology, Hadasah Medical Centre-Ein Karem, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Feinmesser
authors.forename: J L
authors.initials: JL
authors.lastname: Freeman
authors.forename: A
authors.initials: A
authors.lastname: Noyek
mesh_terms: D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009362:Neoplasm Metastasis / Q000235:genetics; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm