[Protective effect of the antioxidants selenium, vitamin E, and superoxide dismutase on cultured human endothelial cells (ECs) injured by lipid peroxidation].
Lipid peroxidation was induced in cultured human ECs with cumene hydroxide and the protective effect of antioxidants (selenium, vitamin E and SOD) on endothelial cell injury by lipid peroxidation was investigated. The results showed that after administration of antioxidants (Se, Vit E and SOD), concentration of LPO in ECs induced by cumene hydroperoxide was reduced markedly while 6-Keto-PGF1 alpha content in the medium was increased and cell injury was alleviated. These results indicate that through the protective effect on ECs against lipid peroxidation, antioxidants (Se, Vit E and SOD) might play an important role in retarding the process of atherogenesis.
Yang
X H
XH
Laboratory of Experimental Pathology, Medical University China.
Chen
T Z
TZ
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D012643:Selenium / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D014471:Umbilical Veins / Q000166:cytology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D015121:6-Ketoprostaglandin F1 alpha; D013482:Superoxide Dismutase; D012643:Selenium