title: Syntheses and antifungal activities of dl-griseofulvin and its congeners. I.
abstract: dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a. Molecular calculations on 1a, dl-epigriseofulvin (1b), 3 and 4 were undertaken.
authors.affiliation: Faculty of Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tomozane
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Choshi
authors.forename: S
authors.initials: S
authors.lastname: Kishida
authors.forename: M
authors.initials: M
authors.lastname: Yamato
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D005658:Fungi / Q000187:drug effects; D006118:Griseofulvin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D006118:Griseofulvin