Growth suppression in the Trichuris dysentery syndrome.
The Trichuris Dysentery Syndrome (Ramsey, 1962) is an insidious, chronic condition which has clinical features similar to Crohn's ileocolitis and ulcerative colitis, diseases similarly associated with growth retardation. The attained heights and weights of 19 children at the time of diagnosis of intens, -2.4 Standard Deviation (Z) scores from the Tanner-Whitehouse median with weight, adjusted for height-age, -1.3 Z. We present data on the growth velocities of 11 of the children in the half-year following worm expulsion by mebendazole. These children returned to their home environments without food supplementation or close follow-up, but showed an average height velocity of +5.5 Z and weight velocity (for height-age) of +2.4 Z. Of 8 children with unequivocal height spurts only 3 had any weight spurt. We suggest that the pattern of catch-up growth points to the existence of some specific link between allergy or inflammation in the lower intestinal tract and suppression of linear growth, rather than to stunting due to general deprivation and undernutrition.
Cooper
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ES
Tropical Metabolism Research Unit, University of the West Indies, Kingston, Jamaica.
Bundy
D A
DA
MacDonald
T T
TT
Golden
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MH
D000818:Animals; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004403:Dysentery / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy / Q000469:parasitology / Q000503:physiopathology*
D008463:Mebendazole