title: Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells.
abstract: CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.
authors.affiliation: Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA 02115.
authors.forename: H
authors.initials: H
authors.lastname: Nagasawa
authors.forename: J B
authors.initials: JB
authors.lastname: Little
authors.forename: W C
authors.initials: WC
authors.lastname: Inkret
authors.forename: S
authors.initials: S
authors.lastname: Carpenter
authors.forename: K
authors.initials: K
authors.lastname: Thompson
authors.forename: M R
authors.initials: MR
authors.lastname: Raju
authors.forename: D J
authors.initials: DJ
authors.lastname: Chen
authors.forename: G F
authors.initials: GF
authors.lastname: Strniste
mesh_terms: D000512:Alpha Particles / Q000009:adverse effects*; D002460:Cell Line; D002470:Cell Survival; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007399:Interphase; D011005:Plutonium / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000528:radiation effects
chemical_list: D011005:Plutonium