B-cell lymphoma of the mucosa-associated lymphatic tissue (MALT) presenting with bone marrow and peripheral blood involvement.
A 46-year-old female patient was diagnosed as having a low-grade malignant B-cell lymphoma of the gastric MALT, stage IV, with bone marrow involvement and a leukaemic blood picture. Different from the infiltrate in the gastric mucosa, which consisted mainly of centrocyte-like cells, the leukaemic cells presented with a blood-picture resembling infectious mononucleosis but showing a predominance of plasma cells. Despite these cytological differences, a common clonal origin for both cellular compartments was demonstrated immunophenotypically and genotypically. Low-grade B-cell lymphomas of the MALT may thus initially present with stage IV disease and a leukaemic blood picture.
Griesser
H
H
Department of Pathology, Christian-Albrechts University, Kiel, West Germany.
Kaiser
U
U
Augener
W
W
Tiemann
M
M
Lennert
K
K
D001402:B-Lymphocytes; D001773:Blood Cells / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D015321:Gene Rearrangement; D005838:Genotype; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*