Topical ultraviolet light-absorbing chromophore protects against experimental photokeratitis.
Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1798) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.
Oldenburg
J B
JB
Doheny Eye Institute, Los Angeles, CA 90033.
Gritz
D C
DC
McDonnell
P J
PJ
D000287:Administration, Topical; D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D047188:Chalcones; D002934:Cinnamates / Q000494:pharmacology*; D007634:Keratitis / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D011427:Propiophenones; D011817:Rabbits; D011833:Radiation Injuries, Experimental; D014466:Ultraviolet Rays / Q000009:adverse effects*
D001565:Benzoates; D047188:Chalcones; D002934:Cinnamates; D011427:Propiophenones; C118580:octylmethoxycinnamate; C049935:avobenzone