Transfer of diclofenac sodium across excised guinea pig skin on high-frequency pulse iontophoresis. I. Equivalent circuit model.
High frequency pulse iontophoresis of diclofenac sodium across excised guinea-pig skin was carried out in vitro. An equivalent circuit model was constructed to simulate the time courses of voltage drop across the donor solution and the skin. Parameter values obtained by the least-squares adaptation of the model to observed data were consistent with expectation and validated the proposed model.
Koizumi
T
T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Kakemi
M
M
Katayama
K
K
Inada
H
H
Sudeji
K
K
Kawasaki
M
M
D000818:Animals; D004008:Diclofenac / Q000493:pharmacokinetics*; D004058:Diffusion; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007478:Iontophoresis; D008297:Male; D008954:Models, Biological; D012869:Skin Absorption
D004008:Diclofenac