Ligand binding characteristics of homologous rat and mouse urinary proteins and pyrazine-binding protein of calf.
1. The binding affinities of three classes of homologous proteins, alpha 2u protein from rat urine, major urinary protein of mouse and pyrazine-binding protein of calf nasal mucosa have been determined for a panel of ligands. 2. Best ligands were low threshold odorants for man, but chemically unrelated. 3. The binding spectra of the homologous proteins were different.
Cavaggioni
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Instituto di Fisiologia Umana, Universita di Parma, Italy.
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Tirindelli
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D000818:Animals; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D003460:Crystallization; D007782:Lactoglobulins / Q000378:metabolism; D008024:Ligands; D008297:Male; D051379:Mice; D009812:Odorants; D009831:Olfactory Mucosa / Q000032:analysis; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D011507:Proteinuria; D011719:Pyrazines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D018035:Receptors, Odorant
D002352:Carrier Proteins; D007782:Lactoglobulins; D008024:Ligands; D011506:Proteins; D011719:Pyrazines; D018035:Receptors, Odorant; C035737:major urinary proteins; C045648:odorant-binding protein; C034376:2-isobutyl-3-methoxypyrazine