title: [Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system].
abstract: Effects of a 70% methanolic extract (E-S) from the dried leaves of Epimedium sagittatum on a phagocytic activity of reticuloendothelial system were studied by the carbon clearance method in mice. The clearance-rate of carbon significantly increased 1 h after the oral administration of E-S (200 or 500 mg/kg, one time/d for 5d). E-S activated the phagocytosis of carbon by Kupffer cells in the liver. Icariin and epimedin C isolated from E-S also activated the phagocytosis. These results suggest that E-S promotes the phagocytic activity of the reticuloendothelial system in mice and has a stimulatory effect on macrophage.
authors.affiliation: Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Sakakibara
authors.forename: M
authors.initials: M
authors.lastname: Mizuno
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Shiomoto
authors.forename: M
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008247:Lysosomes / Q000201:enzymology; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D000135:Acid Phosphatase