Block-units method for conformational calculations of large nucleic acid chains. II. The two-hierarchical approach and its application to conformational arrangement of the unusual T psi C loop of rabbit tRNA(Val).
The two-level hierarchical methodology is suggested for conformational calculations of large fragments of nucleic acids. The method of the first level is intended for performing a fast screening of the conformational phase space. The high-level method may be used to refine structurally important conformations. The method of the first level is the block-units method, which has been developed specially for these purposes (see part I). It has been shown that the block-units method allows the satisfactory calculation of the structure parameters of the optimal conformations of polynucleotides. The results of the conformational rearrangement calculations of the T psi C loop of the tRNA(Phe) after modification of its sequence are represented.
Vorobjev
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YN
Institute of Bioorganic Chemistry, Siberian Division, USSR Academy of Sciences, Novosibirsk.
D000818:Animals; D008722:Methods; D009690:Nucleic Acid Conformation; D012331:RNA, Fungal; D012345:RNA, Transfer, Amino Acid-Specific; D012360:RNA, Transfer, Phe; D012366:RNA, Transfer, Val; D011817:Rabbits; D015003:Yeasts / Q000235:genetics
D012331:RNA, Fungal; D012345:RNA, Transfer, Amino Acid-Specific; D012360:RNA, Transfer, Phe; D012366:RNA, Transfer, Val