Enhanced intestinal glucose and alanine transport in cystic fibrosis.
The rise in short-circuit current associated with the active transport of glucose and alanine was measured in intestinal biopsy samples from children with cystic fibrosis. The glucose-induced increase in the short-circuit current was greater in the cystic fibrosis tissues than in control samples over the whole range of concentrations tested (2.5-35 mM), a reflection of an increased maximum rate of transport. Similar results were obtained with alanine. These findings suggest that active Na(+)-linked nutrient transport is enhanced in cystic fibrosis.
Baxter
P
P
Department of Biomedical Science, The University, Sheffield.
Goldhill
J
J
Hardcastle
J
J
Hardcastle
P T
PT
Taylor
C J
CJ
D000293:Adolescent; D000409:Alanine / Q000493:pharmacokinetics*; D001693:Biological Transport, Active; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000378:metabolism*; D004594:Electrophysiology; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism* / Q000502:physiology
D005947:Glucose; D000409:Alanine