99mTc-labelled trimethylmonoiodo-IDA: a new radiopharmaceutical for hepatobiliary imaging.
A new radiopharmaceutical, 99mTc-3-iodo-2,4,6-trimethylphenylcarbamoylmethyl iminodiacetic acid (99mTc-trimethylmonoiodo-IDA) was prepared and evaluated for hepatobiliary scintigraphy. The new agent has less plasma protein binding capacity and greater lipophilicity as compared to that of di-isopropyl-IDA. Hepatobiliary specificity, a short transit time and a high gall bladder-to-liver ratio of the new agent were evident from tissue distribution data in mice. Blood tmax and clearance t1/2 of the radiopharmaceutical were observed at 2 and 3.5 min respectively. The hepatic peak-time tmax (5 min) and release time t1/2 (12.75 min) and release t1/2 (25.00 min) suggest the suitability of this agent for hepatobiliary imaging. Results of hepatobiliary scintigraphy in rabbits have further confirmed the above view.
Chauhan
U P
UP
Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Chander
J
J
Mishra
P
P
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000378:metabolism; D007098:Imino Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011817:Rabbits; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D007098:Imino Acids; D015609:Organotechnetium Compounds; C065266:technetium Tc 99m-3-iodo-2,4,6-trimethylphenylcarbamoylmethyliminodiacetic acid