Ethacrynic acid-induced convulsions and brain noradrenaline in mice.
The intracerebroventricular injection of ethacrynic acid (a 50% convulsive dose; 50 micrograms/mouse) accelerated brain noradrenaline turnover and decreased noradrenaline contents. The decrease in noradrenaline contents was antagonized by 2-amino-5-phosphonovalerate but not by diazepam. Both 2-amino-5-phosphonovalerate and diazepam suppressed the incidence of ethacrynic acid-induced convulsions while reserpine, alpha-methyl-para-tyrosine or FLA-63 augmented it. The results suggest that stimulation by ethacrynic acid of excitatory amino acid neurons enhances-noradrenergic neuronal anticonvulsive activity.
Inoue
M
M
Department of Pharmacology, Kansai Medical University, Osaka, Japan.
Hirose
T
T
Fukai
Y
Y
Zeng
X T
XT
Yasukura
T
T
Ohnishi
S
S
Uriu
T
T
Inagaki
C
C
D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004299:Dopamine beta-Hydroxylase / Q000494:pharmacology; D004976:Ethacrynic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009638:Norepinephrine / Q000032:analysis* / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced*; D013997:Time Factors
D008781:Methyltyrosines; C022260:alpha-methyltyrosine methyl ester; D004299:Dopamine beta-Hydroxylase; D004976:Ethacrynic Acid; D009638:Norepinephrine