[Gastric mucosal prostanoids and non-anesthetic gastric submucosal blood flow under HCl-induced adaptive cytoprotection in rats].
Gastric fundic mucosal content of 5 prostanoids and gastric submucosal blood flow rates in rats were measured under HCl-induced adaptive cytoprotection with a 1 hour interval between oral administration of mild and strong irritants. PGE2 and PGF2a increased transiently after mild irritation (MI) and increased even more after subsequent strong irritation (SI). TXB2 increased after SI, but pretreatment with MI partially suppressed this increase. 6-keto-PGF1a and PGD2 increased only after a single SI. Pretreatment with indomethacin decreased all prostanoids below the control levels. Gastric submucosal blood flow rates increased transiently after MI or SI. Pretreatment with indomethacin prolonged the transient increase of gastric submucosal blood flow after MI. HCl-induced adaptive cytoprotection appeared to be related to the transient increases of PGE2 and PGF2a, which are believed to be unrelated to the blood flow increases after MI.
Orihata
M
M
First Department of Surgery, Juntendo University School of Medicine.
D000818:Animals; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D006851:Hydrochloric Acid / Q000009:adverse effects*; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013929:Thromboxane B2 / Q000378:metabolism
D011453:Prostaglandins; D013929:Thromboxane B2; D006851:Hydrochloric Acid