2-Imidazolethiones protect ascorbic acid from oxidation induced by copper.
The oxidation of ascorbic acid to dehydroascorbic acid was accelerated by metal ions such as copper. This stimulation of ascorbate oxidation was inhibited by the addition of 2-imidazolethiones and other sulfhydryl-containing compounds, but not by 2-imidazolones or phenytoin. Although the 2-imidazolethiones interacted with copper, as shown by a decrease in the ultraviolet absorbance of the compounds, the product formed still protected ascorbate from oxidation. The 2-imidazolethiones are proposed to complex copper through their free -SH groups.
Smith
R C
RC
Department of Animal and Dairy Sciences, Auburn University 36849-5415.
Gore
J Z
JZ
D001205:Ascorbic Acid; D002851:Chromatography, High Pressure Liquid; D003300:Copper; D003545:Cysteine; D003553:Cystine; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D007700:Kinetics; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013871:Thiones / Q000494:pharmacology*
D007093:Imidazoles; D013438:Sulfhydryl Compounds; D013871:Thiones; D003553:Cystine; D003300:Copper; D003606:Dacarbazine; D003545:Cysteine; D001205:Ascorbic Acid; C010243:5-(3-methyl-1-triazeno)imidazole-4-carboxamide