Enhancement of current induced by superfusion of GABA in locus coeruleus neurons by pentobarbital, but not ethanol.
gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conductance increase in all LC neurons tested. In contrast, ethanol did not alter the current and conductance increase induced by bath application of GABA to LC neurons.
Osmanović
S S
SS
Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612.
Shefner
S A
SA
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital