[Interaction of cholestyramine and chloroquine].
The plasma levels of chloroquine after an oral intake of 10 mg/kg were measured in 5 children, with or without simultaneous intake of cholestyramine. Plasma chloroquine levels measured 6 hours after intake were significantly lower in case of simultaneous administration of cholestyramine, in spite of important individual changes. These data suggest a decrease in chloroquine bioavailability in the presence of cholestyramine. However, the methodology used does not allow to assert it.
Gendrel
D
D
Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon.
Verdier
F
F
Richard-Lenoble
D
D
Nardou
M
M
D000293:Adolescent; D001682:Biological Availability; D002648:Child; D002738:Chloroquine / Q000493:pharmacokinetics*; D002792:Cholestyramine Resin / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans
D002792:Cholestyramine Resin; D002738:Chloroquine
Interaction entre cholestyramine et chloroquine.