[Perpropionic and peracetic acids destroy HIV in suspension, but do not inhibit the virus in contaminated units of blood].
The virucidal activity of peracetic and perpropionic acids was evaluated against HIV in an attempt to inactivate the virus which might contaminate blood units collected from donors. The results showed first that doses of peracids as weak as 50 ppm were able to kill the virus in free suspension, but that the doses that did not adversely affect blood components did not inactivate the virus in those components.
Lopez
M
M
Inserm U-76 et Institut National de Transfusion Sanguine, Paris, France.
Hénin
Y
Y
Nguyen
L
L
Salmon
C
C
D000085:Acetates / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects / Q000382:microbiology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D010463:Peracetic Acid / Q000494:pharmacology*; D010545:Peroxides / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000085:Acetates; D000998:Antiviral Agents; D010545:Peroxides; D011422:Propionates; C065381:perpropionic acid; D010463:Peracetic Acid
Les acides perpropionique et peracétique détruisent le VIH en suspension, mais n'inhibent pas le virus dans les unités de sang contaminé.