[Effects of intra-arterial infusion of degradable starch microspheres on liver tissue blood flow].
The effects of intra-arterial infusion of degradable starch microspheres (DSM) on liver tissue blood flow were estimated in rat with liver carcinoma induced by 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) administration. Tissue blood flow of tumor and normal liver was measured simultaneously by Laser blood flowmeter. Tissue blood flow of tumor and normal liver was 13.3 +/- 6.9, 13.2 +/- 4.3 (ml/min/100 g), respectively. After intra-arterial infusion of DSM, tissue blood flow of both tumor and normal liver decreased to the same degree as that at hepatic artery occlusion and then gradually recovered. This gradual recovery of tissue blood flow was supposed to express the process of resolution of DSM by alpha-amylase. The recovery time of tissue blood flow following intra-arterial infusion of DSM was 27.3 +/- 4.0 min (DSM 20 mg/kg) and 70.0 +/- 23.6 min (DSM 30 mg/kg) in tumor and 20.0 +/- 3.3 min and 36.5 +/- 18.0 min, respectively, in normal liver. Thus, the blocking effect of blood flow by DSM was different between tumor and normal liver and proved to be more persistent in the former.
Shibasaki
M
M
Second Dept. of Surgery, Faculty of Medicine, University of Tokyo.
Sanjo
K
K
Bandai
Y
Y
Imamura
H
H
Nomura
Y
Y
Hirata
M
M
Chou
S
S
Minagawa
M
M
Hashimoto
M
M
Ohashi
K
K
D000818:Animals; D007261:Infusions, Intra-Arterial; D008102:Liver Circulation / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000494:pharmacology*
D008749:Methyldimethylaminoazobenzene; D013213:Starch