Wegener's granulomatosis with renal involvement: a 14 year experience.
Over a 14 year period 17 patients (nine men) with Wegener's granulomatosis and renal involvement had a renal biopsy. All patients had a necrotising glomerulonephritis and 15 had evidence of crescent formation in glomeruli. Fourteen patients were treated with both prednisone and cyclophosphamide and three with prednisone and azathioprine. The five year patient survival rate was 73% and the renal survival rate 68%.
Sizeland
P C
PC
Department of Nephrology, Christchurch Hospital.
Bailey
R R
RR
Lynn
K L
KL
Robson
R A
RA
D000328:Adult; D000368:Aged; D001706:Biopsy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000209:etiology / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies
D003520:Cyclophosphamide; D011241:Prednisone