title: Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA.
abstract: Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.
authors.affiliation: Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
authors.forename: E I
authors.initials: EI
authors.lastname: Frolova
authors.forename: E M
authors.initials: EM
authors.lastname: Ivanova
authors.forename: V F
authors.initials: VF
authors.lastname: Zarytova
authors.forename: T V
authors.initials: TV
authors.lastname: Abramova
authors.forename: V V
authors.initials: VV
authors.lastname: Vlassov
mesh_terms: D001483:Base Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004249:DNA Damage; D004277:DNA, Single-Stranded; D006418:Heme / Q000031:analogs & derivatives; D006427:Hemin; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010880:Piperidines
chemical_list: D004277:DNA, Single-Stranded; D009838:Oligodeoxyribonucleotides; D010880:Piperidines; D006418:Heme; C032727:piperidine; D006427:Hemin