Resorption of CBA/J x DBA/2 mouse conceptuses in CBA/J uteri correlates with failure of the feto-placental unit to suppress natural killer cell activity.
Lipid extraction was used to study the natural killer (NK) suppressive activity of individual feto-placental units. Normal pregnancies showed a lipophilic NK cell suppressive factor that was gestational day specific. Feto-placental units from CBA/J x DBA/2 pregnancies were deficient in the NK cell suppressive factor when compared to normal CBA/J x BALB/c pregnancies. The frequency of non-suppressive feto-placental units from CBA/J x DBA/2 pregnancies correlated with the frequency of feto-placental units infiltrated with NK cells and the frequency of spontaneous resorption. Our results implicate a deficiency of NK suppressive activity in the feto-placental unit as a contributing factor in spontaneous fetal resorption.
Gendron
R L
RL
Department of Physiology, McGill University, Montreal, Quebec, Canada.
Farookhi
R
R
Baines
M G
MG
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D005260:Female; D005313:Fetal Death / Q000276:immunology*; D005327:Fetal Resorption / Q000276:immunology*; D005333:Fetus / Q000187:drug effects / Q000276:immunology; D005865:Gestational Age; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010920:Placenta / Q000187:drug effects / Q000276:immunology; D011247:Pregnancy; D013491:Suppressor Factors, Immunologic / Q000502:physiology*
D013491:Suppressor Factors, Immunologic; D001241:Aspirin