Determination of thiabendazole, 5-hydroxythiabendazole, fenbendazole, and oxfendazole in milk.
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10 ppb level were 80% or greater with an intralaboratory coefficient of variation of 11% or less. Recovery of 5-hydroxythiabendazole (5-OH-TBZ) at the 30 ppb level averaged 56% with an intralaboratory coefficient of variation of 5%. Limited data on the depletion of FBZ, OFZ, TBZ, and 5-OH-TBZ in milk were also generated.
Tai
S S
SS
National Institute of Standards and Technology, Organic Analytical Division, Gaithersburg, MD 20899.
Cargile
N
N
Barnes
C J
CJ
D000818:Animals; D001562:Benzimidazoles / Q000032:analysis*; D002417:Cattle; D002853:Chromatography, Liquid; D004350:Drug Residues / Q000032:analysis; D005273:Fenbendazole / Q000032:analysis; D007202:Indicators and Reagents; D008892:Milk / Q000032:analysis*; D013827:Thiabendazole / Q000031:analogs & derivatives / Q000032:analysis
D001562:Benzimidazoles; D007202:Indicators and Reagents; D005273:Fenbendazole; C035151:5-hydroxythiabendazole; D013827:Thiabendazole; C011030:oxfendazole