Frequency and effects of the apolipoprotein A-IV polymorphism.
Plasma from 158 presumed healthy nuclear families has been analyzed by high-resolution, two-dimensional electrophoresis to study the frequency and effects of the genetic polymorphism in human apolipoprotein A-IV. Two common alleles, apo A-IV 1 and apo A-IV 2 were detected with relative frequencies of 0.943 and 0.057, respectively. Autosomal codominant transmission of these two alleles coded for by a single structural locus was demonstrated. Furthermore, we studied the effects of this apo A-IV variability on total plasma cholesterol, triglyceride, glucose levels and gamma-glutamyltransferase activity. Statistically significant differences among apo A-IV genotypes for the average glucose level were detected. The average effect of the apo A-IV 1 allele was to lower plasma glucose levels by 0.013 mmol/l, whereas the average effect of the apo A-IV 2 allele was to raise glucose levels by 0.213 mmol/l.
Visvikis
S
S
Centre de Médecine Préventive, UA CNRS 597, Vandoeuvre-Les-Nancy, France.
Steinmetz
J
J
Boerwinkle
E
E
Gueguen
R
R
Galteau
M M
MM
Siest
G
G
D000328:Adult; D001054:Apolipoproteins A / Q000235:genetics* / Q000494:pharmacology / Q000502:physiology; D001786:Blood Glucose; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001786:Blood Glucose; D014280:Triglycerides; C022205:apolipoprotein A-IV