Prevention of T-2 toxin-induced morphologic effects in the rat by highly activated charcoal.
The efficacy of a highly activated charcoal in preventing the morphologic effects of T-2 toxin was examined in female rats. T-2 toxin at 25 mg/kg (6 x LD50) was given orally to all rats. Half the rats also received the charcoal, at a dose of 9 ml/kg and a concentration of 104 mg/ml, while the other half received water. A charcoal-treated rat (T-2 toxin + charcoal) was killed at the time of death of each positive control animal (T-2 toxin alone). Severe necrosis was seen in the spleen, thymus, stomach, small intestine, liver and adrenal glands of the positive controls (T-2 toxin alone). Lesions were absent or minimal in the paired charcoal-treated rats (T-2 toxin + charcoal).
Bratich
P M
PM
Department of Veterinary Biosciences, University of Illinois, College of Veterinary Medicine, Urbana.
Buck
W B
WB
Haschek
W M
WM
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology; D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000473:pathology; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D012717:Sesquiterpenes; D002606:Charcoal; D013605:T-2 Toxin