title: Primary hypothyroidism and human spermatogenesis.
abstract: Spermatogenic function was studied in 10 patients, previously diagnosed as having primary hypothyroidism, in whom a state of hypothyroidism has been induced by discontinuation or a decrease in treatment with levothyroxine over at least one spermatogenic cycle. Most of the patients had fathered children before the study. When the results obtained in the hypothyroid state were compared with those from a group of 16 controls with proven fertility, slight anomalies were observed; these were characterized by a decrease in seminal volume (p less than 0.05), progressive forward motility (p less than 0.01), and the cumulative percentage of mobile forms (p less than 0.01). There were no anomalies in sperm density or in the percentage of spermatozoa with normal morphology. No alterations in circulating levels of testosterone and gonadotropins existed. Induction of hypothyroidism did not lead to seminal or hormonal modifications compared with the same patients in a situation of euthyroidism. Short-term postpuberal hypothyroidism did not cause seminal alterations sufficiently intense to induce male infertility.
authors.affiliation: Departamento de Medicina, Hospital Clínico Universitario, Salamanca, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Corrales Hernández
authors.forename: J M
authors.initials: JM
authors.lastname: Miralles García
authors.forename: L C
authors.initials: LC
authors.lastname: García Diez
mesh_terms: D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D013091:Spermatogenesis; D013375:Substance Withdrawal Syndrome / Q000150:complications; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000009:adverse effects / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine