[Effect of enkephalins and naloxone on the activity of the kallikrein-kinin system in experimental hemorrhagic shock].
The effect of enkephalin derivates with different receptor subtype specificity and opioid antagonist naloxone on kallikrein-kinin system was studied in anaesthetized rats exposed to 30% hemorrhage. Hemorrhage by itself caused only a slight activation of KKS. Pretreatment with naloxone induced a significant activation of KKS, which was potentiated by subsequent hemorrhage.
Kühne
H
H
Institut für Pathologische Biochemie, Medizinischen Akademie Carl Gustav Carus, Dresden.
Grässler
J
J
Steinke
M
M
Slepuschkin
V D
VD
Zoloev
G K
GK
D000818:Animals; D004745:Enkephalins / Q000494:pharmacology*; D007610:Kallikreins / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000378:metabolism*
D004745:Enkephalins; D007705:Kinins; D009270:Naloxone; D007610:Kallikreins
Einfluss von Enkephalinen und Naloxon auf die Aktivierung des Kallikrein-Kinin-Systems im experimentellen hämorrhagischen Schock.