[The effect of the degree of hemoglobin polymerization on its interaction with the body].
Solutions of pyridoxylated polyhemoglobin (PPHb) with the different degree of polymerization (0-53%) were injected intravenously into rats (1 g/kg). The quantity of PPHb, circulating in plasma, being excreted with the urine and accumulated in the organs have been estimated during the first 6 hours after the infusion. During this period 25-40% of the injected PPHb have been found in the urine and 10-25% have been found in plasma, the percentage depending on the degree of polymerization. For all the substances studied 50% accumulation in organs have been observed, the fact of accumulation being proved by the pathologicoanatomic studies. In the present study the localization and the quantity of hemosiderin granules in the organs was the same for the modified hemoglobins with the different degree of polymerization.
Azhigirova
M A
MA
Vashkevich
M G
MG
Kontuganov
N N
NN
Loginova
L N
LN
D000818:Animals; D001802:Blood Substitutes / Q000032:analysis / Q000493:pharmacokinetics*; D001810:Blood Volume / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006454:Hemoglobins / Q000032:analysis / Q000493:pharmacokinetics*; D006485:Hemosiderin / Q000378:metabolism; D011108:Polymers / Q000032:analysis / Q000493:pharmacokinetics*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D001802:Blood Substitutes; D006454:Hemoglobins; D011108:Polymers; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate; D006485:Hemosiderin
Vliianie stepeni polimerizatsii gemoglobina na ego vzaimodeĭstvie s organizmom.