The effects of cholecystokinin octapeptide on human isolated alimentary muscle.
1. We studied cholecystokinin octapeptide (CCK-OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. 2. CCK-OP induced a concentration-dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. 3. CCK-OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones.
D'Amato
M
M
Department of Surgery, King's College School of Medicine and Dentistry, Rayne Institute, London.
Stamford
I F
IF
Bennett
A
A
D000109:Acetylcholine / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects*; D006801:Humans; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D001285:Atropine; D012844:Sincalide; D000109:Acetylcholine