Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication.
Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.
Mikalsen
S O
SO
Laboratory for Environmental and Occupational Cancer, Norwegian Radium Hospital, Oslo.
D000818:Animals; D001592:Benzyl Alcohols / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D008647:Mesocricetus; D009574:Nitro Compounds / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D009574:Nitro Compounds