Retinal vasculature of the fovea of the squirrel monkey, Saimiri sciureus: three-dimensional architecture, visual screening, and relationships to the neuronal layers.
The retinal vasculature of the fovea of squirrel monkeys was studied in retinal whole mounts and in sections of the same retinas. At the center of the fovea there is an approximately circular avascular zone surrounded by a set of terminal capillaries in the inner nuclear layer. Within the foveal depression, four capillary planes that bear a precise relationship to the neuronal organization appear in a specific sequence with increasing eccentricity. The first plane to be established is the dominant, most voluminous one, located closest to the photoreceptors at the deep (sclerad) border of the inner nuclear layer. A second major plane appears next at the sclerad border of the ganglion cell layer. The two remaining, less voluminous planes occur at a slightly greater eccentricity. One of these, located at the shallow (vitread) border of the inner nuclear layer, often drains into the ganglion cell plane. The fourth plane is initially situated at the vitread border of the ganglion cell layer; with increasing eccentricity it moves into the nerve fiber layer. These capillaries are oriented like the nerve fibers with which they travel. Both the shallow inner nuclear and nerve fiber planes of capillaries show marked regional variations. The capillary planes are within or adjacent to regions of high cytochrome oxidase activity. The retinal vascular network is an unrecognized contributor to the optical filtering properties of the eye. In much of the central retina, a photon has a 40-50% chance of encountering one or more capillaries before it reaches a photoreceptor.
Snodderly
D M
DM
Neuroscience Unit, Eye Research Institute of Retina Foundation, Boston, Massachusetts 02114.
Weinhaus
R S
RS
D000818:Animals; D002196:Capillaries / Q000033:anatomy & histology; D002427:Cebidae / Q000033:anatomy & histology*; D005584:Fovea Centralis / Q000098:blood supply*; D008266:Macula Lutea / Q000098:blood supply*; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology*; D012171:Retinal Vessels / Q000033:anatomy & histology* / Q000294:innervation; D012453:Saimiri / Q000033:anatomy & histology* / Q000502:physiology; D014785:Vision, Ocular