Multifetal pregnancy in a gonadal dysgenesis mosaic.
A successful triplet gestation in a 45,X/46,XY woman is presented. A previously hypoplastic uterus was prepared for implantation by exogenous hormone replacement. Conception was achieved through in vitro fertilization of donor oocytes and transfer of four embryos into a hormonally primed endometrium. This case illustrates that some women with 45,X/46,XY karyotype can have a successful triplet pregnancy. Therefore, a conservative approach during gonadectomy in patients with a Y chromosome may be warranted.
Bardeguez
A D
AD
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark.
De Ziegler
D
D
Weiss
G
G
D000328:Adult; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006059:Gonadal Dysgenesis / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D009030:Mosaicism; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000097:blood; D011374:Progesterone / Q000627:therapeutic use; D014310:Triplets; D014599:Uterus / Q000002:abnormalities / Q000187:drug effects
D004967:Estrogens; D011374:Progesterone