title: New antifungal antibiotics, pradimicins D and E. Glycine analogs of pradimicins A and C.
abstract: New antifungal antibiotics pradimicins D and E were isolated from the culture filtrates of Actinomadura hibisca P157-2 (ATCC 53557) and its mutant A2660 (ATCC 53762). The structure of pradimicin D is N-[[(5S,6S)-5-O-[4,6-dideoxy-4-(methylamino)-3-O-(beta-D- xylopyranosyl)-beta-D-galactopyranosyl]-5,6,8,13-tetrahydro-1,6,9,14- tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen++ +-2-yl] carbonyl]glycine, based on spectral analyses compared to pradimicin A. Pradimicin E is the des-N-methyl analog of pradimicin D. Pradimicins D and E were equal in activity to pradimicin A in vitro against a variety of fungi and in vivo against Candida albicans A9540 in mice.
authors.affiliation: Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Hatori
authors.forename: T
authors.initials: T
authors.lastname: Miyaki
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D000192:Actinomycetales / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002177:Candidiasis / Q000188:drug therapy*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D009154:Mutation; D013056:Spectrophotometry, Ultraviolet; D015003:Yeasts / Q000187:drug effects; D000095643:Pradimicins and Benanomicins
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C065440:pradimicin E; D000095643:Pradimicins and Benanomicins; C065439:pradimicin D