A monoclonal antibody (Mab 67) marks type B synoviocytes.
The functionally important lining cells of the synovium (types A and B synoviocytes) are the subjects of much study but have presented problems with their characterization and microscopical identification, particularly at the light level. Type A (macrophage-like) synoviocytes, however are more easily localized than the type B (fibroblast-like) variety because of the greater availability of antimacrophage antisera. We describe, using light and electron microscopy, a monoclonal antibody which in the synovial intimal layer is specific for type B synoviocytes.
Stevens
C R
CR
Bone and Joint Research Unit, London Hospital Medical College, UK.
Mapp
P I
PI
Revell
P A
PA
D000911:Antibodies, Monoclonal / Q000276:immunology*; D015925:Cryopreservation; D005347:Fibroblasts / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D012116:Resins, Plant; D013583:Synovial Membrane / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D012116:Resins, Plant