title: Soft lens lubricants and prelens tear film stability.
abstract: Soft contact lens wearers complaining of "dry eye" are frequently prescribed rewetting drops, although the mode of action and efficacy of this treatment have not been established. Enhancement of prelens tear film (PLTF) stability could provide a basis for symptomatic relief with solution instillation. Thirty symptomatic hydroxyethyl methacrylate (HEMA) lens wearers participated in 4 separate trials of no solution (baseline), saline, and 2 soft lens lubricants. Solutions were applied for a 6-h adaptation period, and PLTF noninvasive break-up time (NIBUT) was monitored for 1 h after a final instillation. PLTF NIBUT was significantly elevated 1 min after instillation of all solutions (p less than 0.001, logrank test) but this effect persisted for less than 5 min. The transient enhancement of PLTF stability arising from the instillation of these rewetting solutions is unlikely to provide a basis for prolonged symptomatic relief.
authors.affiliation: Department of Optometry, University of Melbourne, Parkville, Australia.
authors.forename: T R
authors.initials: TR
authors.lastname: Golding
authors.forename: N
authors.initials: N
authors.lastname: Efron
authors.forename: N A
authors.initials: NA
authors.lastname: Brennan
mesh_terms: D000293:Adolescent; D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008153:Lubrication; D008297:Male; D008689:Methacrylates; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D013666:Tears / Q000187:drug effects*
chemical_list: D008689:Methacrylates; D009883:Ophthalmic Solutions; C005044:hydroxyethyl methacrylate