title: High-dose contrast agent administration during complex coronary angioplasty.
abstract: To examine the necessity and consequences of high-dose contrast media administration during coronary angioplasty, the records of 730 consecutive patients over a 6-month period were reviewed. The 54 patients (7%) requiring contrast agent doses greater than or equal to 400 ml were examined in detail. The mean contrast dose in this group was 496 +/- 76 ml (range 400 to 785 ml). Their mean age was 63 +/- 11 years (range 36 to 83 years), 10 patients had diabetes mellitus (19%), and four patients had a baseline creatinine level greater than or equal to 1.5 mg/dl (7%). Following coronary angioplasty, the serum creatinine rose from 1.1 +/- 0.2 to 1.2 +/- 0.3 (p = 0.08). The creatinine rose greater than or equal to 0.5 mg/dl in six patients (11%) and greater than or equal to 1.0 mg/dl in one patient (2%). Five of these six patients had either diabetes mellitus, baseline renal insufficiency, or both. Oliguria was not observed. The most important procedural factors contributing to the high doses of contrast media were multilesion and multivessel angioplasty in 96% and 83% of patients, respectively, prior bypass surgery in 52%, and combined diagnostic cardiac catheterization and angioplasty in 13%. Thus renal dysfunction following high-dose contrast agent administration during complex coronary angioplasty is infrequently associated with nephrotoxicity. Whenever possible, contrast doses in patients with diabetes mellitus and renal insufficiency should be minimized.
authors.affiliation: Cardiovascular Consultants, Inc., Mid America Heart Institute, Kansas City, MO 64111.
authors.forename: J K
authors.initials: JK
authors.lastname: Kahn
authors.forename: B D
authors.initials: BD
authors.lastname: Rutherford
authors.forename: D R
authors.initials: DR
authors.lastname: McConahay
authors.forename: W L
authors.initials: WL
authors.lastname: Johnson
authors.forename: L V
authors.initials: LV
authors.lastname: Giorgi
authors.forename: T M
authors.initials: TM
authors.lastname: Shimshak
authors.forename: G O
authors.initials: GO
authors.lastname: Hartzler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects; D003404:Creatinine / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007432:Intraoperative Period; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D003287:Contrast Media; D003404:Creatinine