Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata.
A new sesquiterpene pyridine alkaloid, emarginatine B [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine B showed potent cytotoxicity against human KB cells (ED50 = 0.4 micrograms/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.
Kuo
Y H
YH
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill.
Chen
C H
CH
Kuo
L M
LM
King
M L
ML
Wu
T S
TS
Haruna
M
M
Lee
K H
KH
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D008453:Maytansine / Q000302:isolation & purification; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C064682:emarginatine A; C064681:emarginatine B; D008453:Maytansine