d-Ibuprofen in ocular inflammation induced by paracentesis of the rabbit eye.
The anti-inflammatory compound d-ibuprofen has been investigated for anti-inflammatory and cyclooxygenase inhibitory activity in ocular inflammation induced by paracentesis of eyes of living rabbits. d-Ibuprofen is the dextro-rotary isomer of ibuprofen, a potent non-steroidal anti-inflammatory agent. Eyes pretreated topically with d-ibuprofen 0.8% showed a significant inhibition of aqueous protein (73.0%) and prostaglandin E2 (96.4%) increase after paracentesis as compared to paracentesized untreated fellow eyes and control eyes. In aqueous humor no significant correlation between the increase in prostaglandin E2 and protein could be established after paracentesis. These results indicate that d-ibuprofen could be a useful ocular anti-inflammatory agent as cyclooxygenase inhibitor.
Tjebbes
G W
GW
Department of Ophthalmology, University of Leiden, The Netherlands.
van Delft
J L
JL
Barthen
E R
ER
van Haeringen
N J
NJ
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism; D007052:Ibuprofen / Q000627:therapeutic use*; D011677:Punctures; D011817:Rabbits
D005136:Eye Proteins; D015232:Dinoprostone; D007052:Ibuprofen