title: A physiological increase in LH may influence vascular permeability in the rat testis.
abstract: Adult male rats were injected with different doses of hCG, or with 2.5 micrograms ovine LH subcutaneously, and other rats were mated with oestrous females. The animals were examined 4 h after treatments. Treatment with hCG resulted in a dose-dependent increase in leucocyte concentration in testicular blood vessels and in the number of blood vessels which could be labelled with intravenously injected carbon particles. Carbon leakage was not observed in control testes. Treatment with a low dose of ovine LH or inducing an endogenous LH peak by mating also resulted in leucocyte accumulation and vascular leakage of carbon in the testis. The magnitude of the response was considerably lower than after high doses of hCG. The physiological relevance of the discrete response observed after physiological LH stimulation is unknown but LH-induced changes in testicular microcirculation could be of interest for the understanding of the physiology and pathophysiology of the testis.
authors.affiliation: Department of Anatomy, University of Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Bergh
authors.forename: J E
authors.initials: JE
authors.lastname: Damber
authors.forename: A
authors.initials: A
authors.lastname: Widmark
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D006063:Chorionic Gonadotropin / Q000493:pharmacokinetics; D003307:Copulation / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology; D007986:Luteinizing Hormone / Q000493:pharmacokinetics / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000098:blood supply / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
chemical_list: D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone