title: Summary of safety evaluation toxicity studies of glufosinate ammonium.
abstract: This article reviews the results of toxicity studies to evaluate the safety of the herbicide glufosinate ammonium (GLA) and its formulation (200 g/litre) in laboratory animals. The data show that GLA and its formulation are slightly toxic following oral exposure. In addition, the formulation induced GLA and its formulation are slightly toxic following oral exposure. In addition, the formulation induced slight dermal toxicity and eye irritation. Testing for teratogenicity in rats and rabbits indicated no teratogenic potential, and numerous mutagenicity tests showed GLA to be non-genotoxic. Chronic toxicity testing in rats and dogs yielded no-observable-effect levels of 2 and 5 mg/kg body weight/day, respectively. Oncogenicity studies in rats and mice revealed no carcinogenic potential. On the basis of these toxicity data it is concluded that this herbicide is safe under conditions of recommended use.
authors.affiliation: Hoechst Aktiengesellschaft, Frankfurt am Main, Federal Republic of Germany.
authors.forename: E
authors.initials: E
authors.lastname: Ebert
authors.forename: K H
authors.initials: KH
authors.lastname: Leist
authors.forename: D
authors.initials: D
authors.lastname: Mayer
mesh_terms: D000613:Aminobutyrates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006168:Guinea Pigs; D006540:Herbicides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D012867:Skin / Q000187:drug effects
chemical_list: D000613:Aminobutyrates; D006540:Herbicides; C003121:phosphinothricin