A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
Gubbay
J
J
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
Collignon
J
J
Koopman
P
P
Capel
B
B
Economou
A
A
Münsterberg
A
A
Vivian
N
N
Goodfellow
P
P
Lovell-Badge
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012732:Sex Determination Analysis; D013737:Testis / Q000196:embryology* / Q000378:metabolism; D014998:Y Chromosome
D004268:DNA-Binding Proteins