Glutathione S-transferases in alcoholic liver disease.
There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.
Harrison
D J
DJ
Department of Pathology, University of Edinburgh.
May
L
L
Hayes
P C
PC
Haque
M M
MM
Hayes
J D
JD
D000328:Adult; D000368:Aged; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D005982:Glutathione Transferase