title: Association between acute lymphoblastic leukemia and partial IgA deficiency in a young man--a family study.
abstract: We report on an unusual association between partial IgA deficiency and acute lymphoblastic leukemia in a young man. We also report results of the family study of immunoglobulin levels, sIgA B cells, in vitro IgA synthesis and molecular analysis of the structural C alpha genes. The IgA deficiency was present at diagnosis of leukemia prior to any therapy. The indirect arguments for a preexisting IgA deficiency are the absence of improvement of the IgA level during complete remission and especially the finding of a similar partial IgA deficiency in a sister who shared the same HLA haplotype, had a low percentage of sIgA B cells and decreased in vitro IgA production. The mother, who had a normal IgA serum level also had decreased in vitro IgA synthesis. No major structural C alpha gene defect was found. The relationship between acute lymphoblastic leukemia and IgA deficiency remains to be elucidated.
authors.affiliation: Laboratoire d'Immunopathologie, CHU, Angers, France.
authors.forename: A
authors.initials: A
authors.lastname: Chevailler
authors.forename: N
authors.initials: N
authors.lastname: Ifrah
authors.forename: R C
authors.initials: RC
authors.lastname: Monteiro
authors.forename: G
authors.initials: G
authors.lastname: Keyeux
authors.forename: G
authors.initials: G
authors.lastname: Renier
authors.forename: M P
authors.initials: MP
authors.lastname: Lefranc
authors.forename: P
authors.initials: P
authors.lastname: Lesavre
authors.forename: D
authors.initials: D
authors.lastname: Hurez
mesh_terms: D000293:Adolescent; D000328:Adult; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000235:genetics; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D007070:Immunoglobulin A