[Relation of the antitumor activity of 4'-epidoxorubicin and cytogenetic disorders of tumor cells in experimental studies].
Antitumor and cytogenetic activities of 4-epi-doxorubicin (EDR), an anthracycline antibiotic, were studied on female Wistar rats with transplantable ascitic ovary tumor (OT). It was shown that after a single administration in a dose of 3 mg/kg, EDR prolonged the average lifespan of the tumor-bearing rats by 213.4 per cent as compared to that in the controls. The maximum number of the aberrant cells in the bone marrow was observed 24 hours after injection of EDR. In 6 day it decreased to the control level. The maximum increase in the number of the OT aberrant cells was recorded 2 days after EDR injection and even in 10 days the number of the aberrant cells amounted to 20.2 +/- 1.3 per cent. It is suggestive of a high selective action of EDR and relation between the EDR antitumor activity and the disturbances in the chromosomal apparatus of the OT cells.
Nersesian
A K
AK
Zil'fian
V N
VN
Kumkumadzhian
V A
VA
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000235:genetics / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000235:genetics*; D015251:Epirubicin / Q000627:therapeutic use*; D005260:Female; D008533:Megakaryocytes / Q000187:drug effects / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000648:ultrastructure; D010053:Ovary / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D015251:Epirubicin
Sviaz' protivoopukholevoĭ aktivnosti 4-épidoksorubitsina s narusheniiami geneticheskogo apparata opukholevykh kletok v éksperimente.