title: A case report of chronic neutropenia: clinical and ultrastructural findings.
abstract: This case report of severe periodontitis concerns a young male patient with chronic idiopathic neutropenia seen between 1981 and 1983 by the School of Dental Medicine of Geneva and from 1984 to 1988 by the Eastman Dental Hospital of London. The patient was maintained by intermittent systemic antibiotics, subgingival chlorhexidine irrigation, conventional debridement, brushing, and wire-mesh and composite splinting of loose teeth. After leaving school, at the patient's express wish, the extreme downhill pattern of the periodontitis resulted in removal of affected teeth and overdenture construction. The extracted teeth and associated soft tissues were examined for relevant plaque and host response features. The intact morphotypes associated with the advancing front of the lesion were invariably Gram-negative or positive coccoid cells, or less commonly short rods, as in all documented forms of periodotitis. Connective tissue destruction was associated with a leucocyte accumulation comprising mainly polymorphonuclear neutrophils (PMN) and plasma cells. Both were observed degenerated more deeply than in routine adult periodontitis, including PMN lysosome loss and lymphocyte maturation within peripheral blood vessels. Only in one instance, one part of the superficial connective tissue of one block contained bacteria. It was concluded that the features of plaque and the lesion suggest a typical first line of defence response as in other forms of periodontitis. From the consideration of the 10 years clinical history of the patient, it is clear that non-surgical management is possible even in extreme cases, without any compromise of the patient's oral or systemic health, and in accord with the patient's wishes.
authors.affiliation: Department of Periodontology, University of London, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Vaughan
authors.forename: T P
authors.initials: TP
authors.lastname: Vrahopoulos
authors.forename: F
authors.initials: F
authors.lastname: Joachim
authors.forename: K
authors.initials: K
authors.lastname: Sati
authors.forename: P
authors.initials: P
authors.lastname: Barber
authors.forename: H N
authors.initials: HN
authors.lastname: Newman
mesh_terms: D000293:Adolescent; D000380:Agranulocytosis / Q000150:complications*; D001862:Bone Resorption / Q000473:pathology; D002908:Chronic Disease; D003238:Connective Tissue / Q000648:ultrastructure; D003773:Dental Plaque / Q000648:ultrastructure; D005891:Gingivitis / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009503:Neutropenia / Q000150:complications*; D009504:Neutrophils / Q000648:ultrastructure; D010518:Periodontitis / Q000209:etiology / Q000473:pathology*; D010519:Periodontium / Q000648:ultrastructure; D011379:Prognosis