[Morphofunctional indices of the effects of pyracryl on the organs of female genital system in rats].
Morphofunctional indices of pyracryl (phosphate poly-2-pyridylethylmethacrilate) effecting reproduction system of Wistar rats have been studied. It has been shown that monthly administration of pyracryl in doses 1 mg/kg and 5 mg/kg lead to infiltration of mast cells and their pronounced degranulation and impairment of blood and lymph microcirculation. As far as gonadotropic effect is concerned, its parametres depend on the administration of pyracryl. Pyracryl in doses of 1 mg/kg stimulates folliculogenesis in ovaries, a dose of 5 mg/kg may cause expressed atresia of growing follicules and changes of oestrous cycle. It is suggested that biologically active substances of mast cells in female reproduction system play an important role in realization of gonadotropic effects of pyracryl.
Iaglov
V V
VV
Sheina
N I
NI
Fesenko
M A
MA
D000818:Animals; D001491:Basophils / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D008407:Mast Cells / Q000187:drug effects; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D011109:Polymethacrylic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D011109:Polymethacrylic Acids; C038799:pyracryl
Morfofunktsional'nye pokazateli vliianiia pirakrila na organy zhenskoĭ polovoĭ sistemy krys.