Neuroendocrine differentiation in a case of acinic cell carcinoma of the parotid gland.
We report a case of acinic cell carcinoma of the parotid gland with neuroendocrine differentiation. Light microscopically, the tumor appeared as clear cell-type acinic cell carcinoma. In addition, the tumor showed neurosecretory features such as Grimelius positivity and the presence of neurosecretory granules by electron microscopy. We suggest that a tumor cell arising from a stem cell can show simultaneous differentiation to both neuroendocrine and acinic cells.
Ito
K
K
Department of Pathology, Tokai University, School of Medicine, Isehara, Japan.
Kakudo
K
K
Mori
I
I
Horiuchi
M
M
Osamura
Y
Y
D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology* / Q000648:ultrastructure; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure