[A randomized study of the treatment of threatened premature labor. Nifedipine versus ritodrine].
The authors compare the efficiency of two drugs in the treatment of threatened premature labour, the one being the calcium inhibitor (nifedipine) and the other a beta-mimetic drug (ritodrine). 62 patients after random selection were divided into two groups: 32 treated with ritodrine and 30 treated with nifedipine. The treatment was carried out over 7 days. The success rate was similar in both groups -72% for the ritodrine group and 63.33% for the nifedipine group. Women receiving nifedipine had slightly greater gain in weeks, six as against five for ritodrine. The side effects which were often found with nifedipine were; hot flushes (in 10 cases) and headaches (4 cases). These symptoms appeared 15-30 minutes after the first dose and were transitory. No neonatal complications were found. The ease with which a calcium inhibitor can be given suggests that it should be used more frequently in the treatment of threatened premature labour and particularly when there are contra-indications to the use of beta-mimetic drugs.
Janky
E
E
Service de Gynécologie, Hôpital Pellegrin, Bordeaux.
Leng
J J
JJ
Cormier
P H
PH
Salamon
R
R
Meynard
J
J
D000328:Adult; D001034:Apgar Score; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D010920:Placenta / Q000033:anatomy & histology / Q000187:drug effects; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation; D012312:Ritodrine / Q000009:adverse effects / Q000627:therapeutic use*; D014590:Uterine Contraction / Q000187:drug effects
D012312:Ritodrine; D009543:Nifedipine
Etude randomisée de traitement de la menace d'accouchement prématuré. Nifédipine versus ritodrine.