[Superoxide dismutase activity of digestive secretions].
A superoxide dismutase (SOD) activity in saliva and gastric juice has been revealed using the NBT reduction and adrenaline autooxidation assays. This activity in saliva is induced mainly by enzymic mechanisms, whereas in gastric juice--by nonenzymic mechanisms. The gel chromatographic analysis of saliva has demonstrated the presence of several SOD isoenzymes. Nonenzymic mechanisms of the SOD activity in gastric juice involve the ionic activity of H+, Cu2+ and that of reduced glutathione. The SOD activity in gastric juice can be decreased by adding antacids and Fe ions. The effect of Fe3+ is found to be different depending on the methods of the SOD activity evaluation. Such metal-chelating agents as histidine and organic acids increase the SOD activity in gastric juice.
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D000293:Adolescent; D000863:Antacids / Q000494:pharmacology; D002648:Child; D002850:Chromatography, Gel; D004063:Digestion; D004381:Duodenal Ulcer / Q000201:enzymology; D005750:Gastric Juice / Q000201:enzymology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012463:Saliva / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000863:Antacids; D013482:Superoxide Dismutase
Superoksiddismutaznaia aktivnost' pishchevaritel'nykh sekretov.