The protective effect of gamma-hydroxybutyrate in regional intestinal ischemia in the hamster.
The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that was completely prevented by gamma-hydroxybutyrate pretreatment. Naloxone partially blocked this protective effect. Allopurinol provided only partial protection against this injury, whereas vitamin E provided none. Treatment with gamma-hydroxybutyrate after ischemia but before reperfusion also provided significant protection. This study clearly demonstrates that gamma-hydroxybutyrate provides significant protection against intestinal ischemic injury and that it may do so via an opiate receptor-mediated mechanism.
Boyd
A J
AJ
Aron M. Rappaport Microcirculation Laboratory, University of Toronto, Ontario, Canada.
Sherman
I A
IA
Saibil
F G
FG
Mamelak
M
M
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D006224:Cricetinae; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D008647:Mesocricetus; D009270:Naloxone / Q000494:pharmacology; D015427:Reperfusion Injury / Q000517:prevention & control; D012978:Sodium Oxybate / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
D006885:Hydroxybutyrates; D014810:Vitamin E; D009270:Naloxone; D000493:Allopurinol; D012978:Sodium Oxybate