Influence of erythropoietin treatment on 2,3-bisphosphoglycerate and O2-affinity of red blood cells in children with renal anemia.
In children with renal anemia the concentration of DPG of red blood cells and the O2-affinity of hemoglobin (P50) were determined before and under treatment with EPO. Before treatment the concentration of DPG was 6.25 mmoles/l cells and the P50 28.9 Torr. A rise of the hematocrit to about 0.30 was accompanied by an increase of DPG to 7.95 mmoles/l cells and of P50 to 32.1 Torr, respectively. Thus improvement of renal anemia by stimulation of erythropoiesis by means of EPO was accompanied by a decreased O2-affinity of hemoglobin and therefore by an additionally improved O2-supply to the tissues.
Rapoport
I
I
Institute of Biochemistry, Humboldt University, Berlin, GDR.
Engelhardt
I
I
Drung
I
I
Holzhütter
H
H
Schmidt
G
G
D019794:2,3-Diphosphoglycerate; D000293:Adolescent; D000740:Anemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004163:Diphosphoglyceric Acids / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D006435:Renal Dialysis
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D004921:Erythropoietin; D019794:2,3-Diphosphoglycerate; D010100:Oxygen