Anticardiolipin antibodies in patients with rabies vaccination induced neurological complications and other neurological diseases.
We reported the occurrence of anticardiolipin antibodies (ACA) by using an enzyme-linked immunosorbent assay (ELISA) in sera of patients with neurologic complications from Semple rabies vaccination. There was a correlation between the presence of ACA and the disease severity. Sixteen of 25 patients (64%) with major neurological complications, 2 of 21 patients (10%) with minor complications, and non of the normal vaccinees had an ACA response. In comparison to this, ACA was found in 10/43 (24%) of patients with post-infectious encephalitis (PIE), Guillain-Barré syndrome (GBS) and multiple sclerosis (MS), 5/22 (23%) and 4/31 (13%) of patients with degenerative neurological diseases and central nervous system (CNS) infections, respectively. There was no specific restriction to any particular isotype. Frequency difference of ACA responses was unremarkable in systemic lupus erythematosus (SLE) patients with (3/9) and without (3/10) CNS involvement. It is not conclusive about the pathogenetic role of ACA. This remains to be determined.
Chaleomchan
W
W
Department of Microbiology, Chulalongkorn University Hospital, Bangkok, Thailand.
Hemachudha
T
T
Sakulramrung
R
R
Deesomchok
U
U
D000906:Antibodies / Q000378:metabolism*; D002308:Cardiolipins / Q000276:immunology*; D004660:Encephalitis / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology*; D009422:Nervous System Diseases / Q000209:etiology / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology*; D011819:Rabies Vaccines / Q000009:adverse effects*
D000906:Antibodies; D002308:Cardiolipins; D011819:Rabies Vaccines