Azathioprine and allopurinol: a potentially dangerous combination.
We report the association of leucopenia and anaemia in five patients given a combination of azathioprine and allopurinol. Three subjects were renal transplant recipients with mild to moderate impairment of graft function. The complication appeared between 4 and 6 weeks following initiation of the combination therapy. Discontinuation of one of the two drugs resulted in full recovery within 4-8 weeks.
Venkat Raman
G
G
Department of Renal Medicine, University of Southampton, St Mary's Hospital, Portsmouth, UK.
Sharman
V L
VL
Lee
H A
HA
D000293:Adolescent; D000328:Adult; D000493:Allopurinol / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects
D000493:Allopurinol; D001379:Azathioprine