title: The clinical features, management and outcome of persistence of the arterial duct presenting in adult life.
abstract: We have reviewed the 25 patients who, between 1973 and 1988, presented to the Brompton Hospital in adulthood with persistence of the arterial duct (ductus arteriosus). As pulmonary arteriolar resistance is the main determinant of management and prognosis in this condition, the patients were divided into groups with either normal or mild elevation of resistance (less than 10 units/m2: 19 patients) or with severe elevation (greater than 10 units/m2: 6 patients). Patients with normal pressures or mild elevation tended to be older (mean age 45 years). Many (70%) were asymptomatic, but dyspnoea with signs of left heart failure was the commonest presenting complaint. Surgical closure of the duct was performed in 16 with good result in all. Survival for the entire group, however, was long. There was a symptomatic indication for surgery (due to hyperdynamic circulation) in 5. In those with severely elevated pulmonary arteriolar resistance, the mean age of presentation was 31 years and the survival short. The commonest presenting symptom was dyspnoea. Surgical closure of the duct was attempted in two patients but with a poor outcome in both. All patients with an elevated resistance had developed this complication by the third decade of life. Significant elevation was not a feature of older patients, suggesting that, in this age group, the risk of elevation is slight. Surgery, nonetheless, may be indicated for relief of symptoms due to a large systemic to pulmonary shunt.
authors.affiliation: Cardiac Department, Brompton Hospital, London, U.K.
authors.forename: J M
authors.initials: JM
authors.lastname: Morgan
authors.forename: H H
authors.initials: HH
authors.lastname: Gray
authors.forename: G A
authors.initials: GA
authors.lastname: Miller
authors.forename: P J
authors.initials: PJ
authors.lastname: Oldershaw
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002303:Cardiac Output, Low / Q000209:etiology; D002932:Cineangiography; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D004417:Dyspnea / Q000209:etiology; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011651:Pulmonary Artery / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology*