Study of the effects of oral administration of CDP-choline on open-field behaviour under conditions of chronic hypoxia.
48 Wistar rats were maintained over a period of 103 days while the oxygen content of the air was continuously reduced. Their behaviour in an open-field was observed at each step of oxygen deficiency (15, 12, 10, 8 and 7% O2 inspiratory). One group (24 animals) was given CDP-choline (cytidine diphosphate choline, Somazina) at a dose of 100 mg/kg body weight administered by addition to the food. Behavioral reactions indicative of deterioration in vigilance were recorded under hypoxic conditions. CDP-choline showed a protective effect increasing vigilance under mild (15% O2) hypoxia, indicating the possibility of treatment of patients with cerebral syndromes secondary to hypoxia.
Hamdorf
G
G
Institute of Neuropathology, Free University of Berlin, Germany.
Cervós-Navarro
J
J
D000284:Administration, Oral; D000818:Animals; D001288:Attention / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002794:Choline / Q000031:analogs & derivatives*; D002908:Chronic Disease; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D003672:Defecation / Q000187:drug effects; D000860:Hypoxia / Q000523:psychology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D003566:Cytidine Diphosphate Choline; D002794:Choline