title: Norepinephrine turnover in brown adipose tissue of young rats: effects of rearing temperature.
abstract: Brown adipose tissue (BAT) has an important role in the thermogenesis of newborn mammals and cold-acclimated rodents. Heat production within the tissue is regulated by the sympathetic nervous system (SNS) via norepinephrine (NE) release. As only little is known of the progressive role of SNS during the developmental period, NE content and turnover were determined in BAT of infant rats 1-33 days of age. The dams and the pups were kept at either 28 or 16 degrees C. It was observed that the NE level in the tissue and the mediator turnover had an almost parallel evolution during the experimental period. In the first week of life, level and turnover of NE were higher in the 28 degrees C group than in the 16 degrees C group. During the second week, the level remained constant in rats kept at 28 degrees C, but the NE turnover slightly decreased. In contrast, a large increase of both parameters was observed in rats kept at 16 degrees C. Then a decrease occurred in both groups until weaning. Subsequently the values remained almost constant. It must be noted that, from the end of the first week, NE content and turnover were always significantly higher in the 16 degrees C group than in the 28 degrees C group. At the end of the first month, the level was 50% higher in cold-acclimated rats and turnover was four times as high as in controls.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratoire d'Adaptation Energétique à l'Environnement, Ecole Pratique des Hautes Etudes, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Bertin
authors.forename: I
authors.initials: I
authors.lastname: Mouroux
authors.forename: F
authors.initials: F
authors.lastname: De Marco
authors.forename: R
authors.initials: R
authors.lastname: Portet
mesh_terms: D000273:Adipose Tissue / Q000032:analysis / Q000033:anatomy & histology / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000032:analysis / Q000033:anatomy & histology / Q000378:metabolism; D000375:Aging / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D005260:Female; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism*; D009929:Organ Size; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000254:growth & development / Q000502:physiology; D013696:Temperature
chemical_list: D009638:Norepinephrine