title: [Hemodiafiltration with high-level ultrafiltration versus hemodialysis. Longitudinal study].
abstract: A group of well nourished young patients was examined during 2 longterm consecutive high efficiency dialytic schedules to detect possible clinical and biochemical differences. The patients were first studied during hemodialysis with a 1.2 m2 cuprophan membrane and blood flow of 400 ml/min and, then, during hemodiafiltration with an ultrafiltration rate greater than 100 ml/min by using high permeability membranes with a surface greater than or equal to 1.4 m2. As expected by the higher clearances obtained on hemodiafiltration, this technique resulted in a significant reduction of dialysis time and of BUN and serum creatinine, associated with a significant increase of hemoglobin, possibly related to a better deintoxication. Furthermore, the dry body weight decreased significantly during hemodialysis, whereas it increased significantly during hemodiafiltration, despite unchanged dietary habits, indicating possible differences in the nutrients utilization during the 2 dialytic schedules. Therefore, in chronically dialyzed patients, highly permeable synthetic membranes should be preferred to cuprophan because of a supposed better biocompatibility and should be used with the highest ultrafiltration rate in order to obtain a better dialytic efficiency and to avoid the risk of backfiltration.
authors.affiliation: Ente Ospedaliero, Casale Monferrato, Servizio di Nefrologia e Dialisi.
authors.forename: M
authors.initials: M
authors.lastname: Gonella
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: A
authors.initials: A
authors.lastname: Mazzotta
authors.forename: G
authors.initials: G
authors.lastname: Pratesi
authors.forename: G
authors.initials: G
authors.lastname: Vagelli
mesh_terms: D000328:Adult; D001806:Blood Urea Nitrogen; D001835:Body Weight; D005069:Evaluation Studies as Topic; D005260:Female; D006440:Hemofiltration / Q000379:methods; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D006454:Hemoglobins; D008567:Membranes, Artificial
vernacular_title: Emodiafiltrazione ad alta ultrafiltrazione vs emodialisi. Studio longitudinale.