title: Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse.
abstract: Hydrocephalus with hop gait (hyh) is a new lethal recessive mouse mutation that arose in the C57BL/10J strain at The Jackson Laboratory. It has been mapped to the proximal end of Chromosome 7 close to the Gpi-1 locus. This homozygous mutant is characterized clinically by a domed head and a hopping gait observable at 2 weeks of age and death between 4 and 10 weeks of age. The affected mice have dilated lateral ventricles and a large third ventricular cyst, patent through narrowed rostral cerebral aqueduct, cystic caudal aqueduct and no communication of the aqueduct with the fourth ventricle. The cerebellum has a mild cortical malformation.
authors.affiliation: Jackson Laboratory, Bar Harbor, ME 04609.
authors.forename: R T
authors.initials: RT
authors.lastname: Bronson
authors.forename: P W
authors.initials: PW
authors.lastname: Lane
mesh_terms: D000818:Animals; D006849:Hydrocephalus / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants / Q000235:genetics* / Q000502:physiology; D009069:Movement Disorders / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D009154:Mutation