title: Paraproteins and primary lymphoma in SJL mice. I. Individuality of idiotypes on paraproteins.
abstract: The isotype distribution and idiotypic determinants of paraproteins (PP) found in sera from aging SJL mice were studied. One or more PP were found in 79% of 9-11 month old mice; the isotypes were gamma 1 greater than or equal to alpha greater than or equal to gamma 2a much greater than gamma 3 much greater than gamma 2b. There was a significant tendency for the PP to occur in pairs or triplets, multiple PP being found in 35% of the mice without an evident association between any two isotypes. Rabbit anti-Id was prepared against four isolated PP, two gamma 1 and two gamma 2a. Inhibition of anti-Id-Id interaction was specific for the immunizing PP only and was absent with all other PP studied (8 gamma 1 and 10 gamma 2 PP) and with normal SJL Ig. It is concluded that SJL PP fail to exhibit cross-reactive idiotypes and show a wider range of isotype distribution than was previously suspected, although PP of mu, delta, and epsilon isotypes are absent.
authors.affiliation: Department of Pathology, New York University Medical Center, New York 10016.
authors.forename: V K
authors.initials: VK
authors.lastname: Tsiagbe
authors.forename: G J
authors.initials: GJ
authors.lastname: Thorbecke
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007074:Immunoglobulin G / Q000032:analysis; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007132:Immunoglobulin Isotypes / Q000032:analysis; D008223:Lymphoma / Q000097:blood* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010266:Paraproteins / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007132:Immunoglobulin Isotypes; D010266:Paraproteins