title: Metabolism of the diuretic bumetanide in healthy subjects and patients with renal impairment.
abstract: The pharmacokinetics and metabolism of orally administered bumetanide were studied in five healthy subjects and in five patients with renal insufficiency. Healthy subjects excreted 51% of the dose as unchanged drug in the urine, whilst the patients with renal insufficiency excreted only 11% of the dose as bumetanide. Similarly the urinary excretion of the gamma-hydroxybutyl metabolite was reduced from 6% in healthy subjects to 2.3% in patients with renal impairment. In both groups of subjects the mean elimination half-life of the metabolite was greater than for bumetanide. The results indicate a possible accumulation of bumetanide and metabolite in patient with renal failure.
authors.affiliation: Department of Clinical Biochemistry, Crosshouse Hospital, Kilmarnock, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Howlett
authors.forename: G G
authors.initials: GG
authors.lastname: Skellern
authors.forename: W H
authors.initials: WH
authors.lastname: Auld
authors.forename: W R
authors.initials: WR
authors.lastname: Murdoch
mesh_terms: D000368:Aged; D002034:Bumetanide / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D004232:Diuretics / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000652:urine; D008297:Male; D008875:Middle Aged
chemical_list: D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide