[The effect of ATP on the malate regulation of oxidative phosphorylation in brain mitochondria].
Malate was studied for its effect on the oxidative phosphorylation rate in the rat brain mitochondria in the presence and absence of ATP, succinate being used as a substrate of the respiration. It has been found that malate in the 0.05-0.4 mM concentration range increases the oxidation phosphorylation rate. ATP inhibiting oxidative phosphorylation intensifies the malate stimulation. The malate 0.8 mM concentration removes the inhibiting action of ATP. The regulatory effects of malate and ATP are supposed to be realized at the adenine nucleotide translocator step.
Samartsev
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D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008293:Malates / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D013379:Substrate Specificity
D008293:Malates; D000255:Adenosine Triphosphate
Vliianie ATP na reguliatsiiu malatom okislitel'nogo fosforilirovaniia mitokhondriĭ mozga.