Three related near-haploid clones in a primary endometrioid carcinoma of the ovary.
We report the cytogenetic findings in a primary endometrioid carcinoma of the ovary from a 29-year-old woman. Three clones with counts of 30, 29, and 27 chromosomes were observed. The predominant clone had 29 chromosomes and the following karyotype: 29, X, -X, -3, -3, +der(3)ins(3;?) (q21;?), -4, -5, -6, -8, -9, -11, -13, -14, -15, -16, -17, -18, -19, -21, -22, +mar. The clone with 30 chromosomes had an additional marker in the form of a minute chromosome, and the clone with 27 chromosomes was monosomic for chromosomes 12 and 20 also. Interestingly, there was no nullisomy of any of the chromosomes.
Sreekantaiah
C
C
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona 85251.
Crickard
K
K
Crickard
U
U
Yoonessi
M
M
Sandberg
A A
AA
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology