title: [HLA and otosclerosis].
abstract: The HLA antigens frequencies were studied in 30 Japanese patients with otosclerosis, and were compared with those of 220 randomly-selected apparently healthy unrelated Japanese. Serological HLA typing was performed by the modified two-stage complement-dependent microcytotoxicity method at the Blood Transfusion Service, Tokyo University Hospital. The results were as follows: There was no significant deviation of HLA class I antigen frequencies in the patients tested as compared with those in controls. As for HLA class II antigens, the DRw11 antigens frequency showed slight increase; however, after the correction of the P value, this was not significant.
authors.affiliation: Department of Otolaryngology, National Tohsei Hospital, Sizuoka.
authors.forename: K
authors.initials: K
authors.lastname: Nibu
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Matsuki
authors.forename: T
authors.initials: T
authors.lastname: Juji
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D006684:HLA-DR Antigens / Q000378:metabolism; D059810:HLA-DR Serological Subtypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C080766:HLA-DR11 antigen