title: Incidence and morphology of spontaneous thyroid tumours in different strains of rats.
abstract: The incidence and morphology of thyroid neoplasms in different strains and stocks of rats are reported. The frequency of thyroid tumours varied to a great extent between different strains of rats. Low incidences were observed in DA/Han (0.85 per cent) and BDII/Han rats (1.25 per cent), while somewhat higher incidences occurred in Han:WIST rats (7.3 per cent). The highest number of thyroid tumour-bearing rats was found in the Han:SPRD stock (55.5 per cent). Thyroid neoplasms were classified histologically as polymorphofollicular adenomas, papillary adenomas, cystadenomas, polymorphofollicular carcinomas, papillary carcinomas, C-cell adenomas and C-cell carcinomas (medullary carcinomas). C-cell neoplasms were predominant in Han:SPRD rats (93.0 per cent), while the majority of tumour-bearing Han:WIST rats (61.4 per cent) had follicular tumours.
authors.affiliation: Central Institute for Laboratory Animal Breeding, Department of Pathology, Hannover, F.R.G.
authors.forename: J
authors.initials: J
authors.lastname: Kaspareit-Rittinghausen
authors.forename: K
authors.initials: K
authors.lastname: Wiese
authors.forename: F
authors.initials: F
authors.lastname: Deerberg
authors.forename: B
authors.initials: B
authors.lastname: Nitsche
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D003537:Cystadenoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000453:epidemiology* / Q000473:pathology; D012737:Sex Factors; D013045:Species Specificity; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*