title: Mortality of cellulose fiber production workers.
abstract: Mortality was studied among 1271 employees of a cellulose fiber production plant in Rock Hill, South Carolina, in the United States. Each subject was employed for at least three months between 1 January 1954 and 1 January 1977 in jobs that entailed exposure to the highest concentrations of methylene chloride. In the cohort 122 deaths were identified through 1 September 1986, and mortality rates for the cohort were compared with mortality rates for York County, South Carolina. Deficit mortality was observed for cancers of the respiratory system, breast, and pancreas and from ischemic heart disease. Excess mortality was observed for cancers of the buccal cavity and pharynx and the liver and biliary tract, and for melanoma as well. The largest relative excess was for liver and biliary tract cancers. There were only four deaths in this category; however, three of the four deaths were cancer of the biliary tract (3 observed, 0.15 expected, standardized mortality ratio 20).
authors.affiliation: Epidemiology Resources Inc, Chestnut Hill, Massachusetts 02167.
authors.forename: S F
authors.initials: SF
authors.lastname: Lanes
authors.forename: A
authors.initials: A
authors.lastname: Cohen
authors.forename: K J
authors.initials: KJ
authors.lastname: Rothman
authors.forename: N A
authors.initials: NA
authors.lastname: Dreyer
authors.forename: K J
authors.initials: KJ
authors.lastname: Soden
mesh_terms: D001661:Biliary Tract Neoplasms / Q000453:epidemiology / Q000209:etiology; D002423:Cause of Death; D002482:Cellulose; D015331:Cohort Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008752:Methylene Chloride / Q000009:adverse effects; D008875:Middle Aged; D009026:Mortality; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000209:etiology; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D010610:Pharyngeal Neoplasms / Q000453:epidemiology / Q000209:etiology; D013783:Textile Industry
chemical_list: D008752:Methylene Chloride; D002482:Cellulose