title: Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of "therapeutic" radon exposure.
abstract: A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by "therapeutic" low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18,del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.
authors.affiliation: Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: M
authors.initials: M
authors.lastname: Berkowicz
authors.forename: E
authors.initials: E
authors.lastname: Rosner
authors.forename: Y
authors.initials: Y
authors.lastname: Neuman
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
authors.forename: B
authors.initials: B
authors.lastname: Ramot
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000209:etiology / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D009153:Mutagens; D011829:Radiation Dosage; D011886:Radon / Q000009:adverse effects* / Q000627:therapeutic use; D013166:Spondylitis / Q000532:radiotherapy
chemical_list: D009153:Mutagens; D011886:Radon