title: Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23.
abstract: The alpha B-crystallin gene (CRYA2) encodes the abundant lens protein alpha B-crystallin. A panel of human/rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster alpha B-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.
authors.affiliation: Department of Molecular Biology and Cell Biology, University of Nijmegen, The Netherlands.
authors.forename: R H
authors.initials: RH
authors.lastname: Brakenhoff
authors.forename: A H
authors.initials: AH
authors.lastname: Guerts van Kessel
authors.forename: M
authors.initials: M
authors.lastname: Oldenburg
authors.forename: J T
authors.initials: JT
authors.lastname: Wijnen
authors.forename: H
authors.initials: H
authors.lastname: Bloemendal
authors.forename: P
authors.initials: P
authors.lastname: Meera Khan
authors.forename: J G
authors.initials: JG
authors.lastname: Schoenmakers
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003459:Crystallins / Q000235:genetics*; D006801:Humans
chemical_list: D003459:Crystallins