title: Comparison of 5-fluorouracil pharmacokinetics following intraperitoneal and intravenous administration using in vivo 19F magnetic resonance spectroscopy.
abstract: Intrahepatic pharmacokinetic studies of 5-Fluorouracil (5 FU) metabolism following intravenous and intraperitoneal administration have been undertaken in four patients using in vivo 19F nuclear magnetic resonance spectroscopy. Following intravenous administration, 5 FU decayed with "half times" ranging from 5 to 17 min. There was considerable variation of 5 FU pharmacokinetics between patients following intraperitoneal administration. Peritoneal contamination by infused 5 FU was considered to be a significant problem in one patient. A technique for providing superficial signal suppression was therefore investigated and its efficacy for excluding signal from the peritoneal space has been demonstrated. Owing to the potential for contamination from peritoneal 5 FU, the accumulation of fluoro-beta-alanine (FBAL) is a more reliable indicator of drug catabolism than the measurement of unlocalized "hepatic" 5 FU. Rapid intrahepatic catabolism of 5 FU to FBAL was demonstrated in all patients. However, there was greater pharmacokinetic variation following intraperitoneal administration than following intravenous administration. Therapeutic implications of intravenous compared with intraperitoneal administration of 5 FU are discussed.
authors.affiliation: Academic Unit of Radiotherapy and Oncology, Royal Marsden Hospital, Sutton, Surrey.
authors.forename: J
authors.initials: J
authors.lastname: Glaholm
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: D
authors.initials: D
authors.lastname: Collins
authors.forename: B
authors.initials: B
authors.lastname: al Jehazi
authors.forename: J C
authors.initials: JC
authors.lastname: Sharp
authors.forename: T A
authors.initials: TA
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Adach
authors.forename: A
authors.initials: A
authors.lastname: Hind
authors.forename: V R
authors.initials: VR
authors.lastname: McCready
authors.forename: H
authors.initials: H
authors.lastname: White
mesh_terms: D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods
chemical_list: D005472:Fluorouracil