title: [Pharmacokinetic and clinical studies on aztreonam in perinatal period].
abstract: Pharmacokinetic and clinical studies were carried out on aztreonam (AZT), a monobactam antibiotic with a high activity against Gram-negative bacteria. The results obtained are summarized as follows: 1. Following 2 g bolus intravenous injection, transfers of AZT to umbilical cord serum and amniotic fluid were found to be satisfactory. AZT level in amniotic fluid was higher than 1 micrograms/ml at 40 minutes after administration and it was at 3.7 micrograms/ml in 23.5 hours. 2. In the treatment of 9 patients with perinatal infections, clinical efficacies of AZT were judged excellent in 3 cases and good in 6 cases. 3. No side effects and abnormal laboratory findings due to the drug were observed in any case. These results indicate that AZT may be a useful antibiotic for the treatment of perinatal infections.
authors.affiliation: Department of Obstetrics and Gynecology, Asahikawa Medical College.
authors.forename: K
authors.initials: K
authors.lastname: Sengoku
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Haga
authors.forename: R
authors.initials: R
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Torii
authors.forename: T
authors.initials: T
authors.lastname: Sagawa
authors.forename: S
authors.initials: S
authors.lastname: Saitou
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D001398:Aztreonam / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D002821:Chorioamnionitis / Q000188:drug therapy; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011704:Pyelonephritis / Q000188:drug therapy; D014591:Uterine Diseases / Q000188:drug therapy
chemical_list: D001398:Aztreonam