Panax ginseng extract modulates sleep in unrestrained rats.
The amount of wakefulness and slow wave sleep (SWS) during the 12-h light period slightly but significantly decreased and increased, respectively, in freely behaving rats after continued 1-week intake of Panax ginseng extract through drinking water (15 mg/day). Paradoxical sleep was little affected. No sleep parameters were modulated by the treatment during the dark period. The diurnal SWS enhancement disappeared and recovered to the baseline level after 2 weeks of continued treatment. It is speculated that the well known health-improving effect of the ginseng may be, at least in part, related to an enhancement of sleep.
Rhee
Y H
YH
Department of Neuropsychiatry, College of Medicine, Chungbuk National University, Korea.
Lee
S P
SP
Honda
K
K
Inoué
S
S
D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D010936:Plant Extracts