[A case-control study of acute leukemia during the 1st year of life].
Infantile leukemias (IL) with onset of the disease in the first year of life account for less than 5% of childhood leukemias. Twenty-four IL cases (age at diagnosis [AD] less than 1 year), treated in a single institution over a 15 year period were analyzed. IL cases were paired with elder leukemic children, matched by type of leukemia (ALL and ANLL), sex, year of diagnosis, and regional residence. For ALL 2 control groups (CG) were chosen: AD 3-6 years (CG1), corresponding to ALL incidence peak in Italy, and AD 6-14 years (CG2); for ANLL (not having age specific incidence peak): AD greater than 3 years. In ALL the main biological differences between IL and CGs are represented by initial WBC count and IgM at onset, significantly higher in IL cases (p less than 0.01 and 0.05, respectively). In ANLL a significant excess of M4/M5 morphology was found among IL (p less than 0.01). Moreover, a significantly shorter survival was found in infantile ALLs vs. CG1, in the stratum with WBC count at onset greater than 50,000/mm3 (p less than 0.05).
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Istituto Nazionale per la Ricerca sul Cancro (IST), Genova.
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D000367:Age Factors; D001724:Birth Weight; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007558:Italy; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000401:mortality; D012307:Risk Factors
Studio caso-controllo delle leucemie acute del primo anno di vita.