[A new method of calculating tissue/blood distribution coefficient in physiological models of pharmacokinetics].
An original simple method for evaluating the tissue/blood distribution coefficient for physiological models of drug pharmacokinetics on the basis of minimal information on the content of a xenobiotic in tissues (one time point) is described. For its testing, the literature data on the pharmacokinetics of sulbactam, ampicillin, THR-221 and NY-198 were used.
Manuĭlov
K K
KK
Kashina
L B
LB
D042462:4-Quinolones; D000667:Ampicillin / Q000493:pharmacokinetics; D000890:Anti-Infective Agents / Q000493:pharmacokinetics; D001769:Blood; D024841:Fluoroquinolones; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D015363:Quinolones; D013407:Sulbactam / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015262:Xenobiotics / Q000493:pharmacokinetics
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015262:Xenobiotics; D000667:Ampicillin; C053091:lomefloxacin; D013407:Sulbactam
Novyĭ metod rascheta koéffitsienta raspredeleniia tkan'/krov' dlia fiziologicheskikh modeleĭ farmakokinetiki.