[Stereological quantitative analysis of LM and EM images on membranous glomerulonephritis (MGN) in rabbits].
MGN model in rabbits was established according to Border's method. The pathological changes of MGN were analysed through stereological quantitation technique under LM and EM. Results indicate that the quantitative parameters of subepithelial electron dense deposits and the glomeruli in the experimental group were remarkably different statistically from those of the control group (P less than 0.05 or P less than 0.001). In the experimental group, the volume density of glomerular crescent or circumferential corpuscle was 17.39% at the 8th week of the experiment. The thickness of glomerular basement membrane was 168 nm in the control group and 627 nm in the experimental group (P less than 0.001).
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Department of Pathology, Luzhou Medical College.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology; D001699:Biometry; D015433:Glomerulonephritis, Membranous / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D010780:Photogrammetry; D011817:Rabbits