title: The gene encoding L1, a neural adhesion molecule of the immunoglobulin family, is located on the X chromosome in mouse and man.
abstract: The murine and human genes for the L1 neural adhesion molecule were shown to lie on conserved regions of the X chromosome to which genes responsible for several neuromuscular diseases have been mapped and which are adjacent to the fragile site (FRAXA) associated with mental retardation. By pulsed-field gel mapping we have demonstrated physical linkage between the L1 gene and other genes located in Xq28: L1 lies between the eye pigment RCP, GCP locus and the glucose-6-phosphate dehydrogenase (G6PD) gene. This location is compatible with the implication of the L1 molecule in one of the X-linked neuromuscular diseases mapped to this region.
authors.affiliation: CIML INSERM-CNRS, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Djabali
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: C
authors.initials: C
authors.lastname: Nguyen
authors.forename: D
authors.initials: D
authors.lastname: Roux
authors.forename: J
authors.initials: J
authors.lastname: Demengeot
authors.forename: F
authors.initials: F
authors.lastname: Denizot
authors.forename: M
authors.initials: M
authors.lastname: Moos
authors.forename: M
authors.initials: M
authors.lastname: Schachner
authors.forename: C
authors.initials: C
authors.lastname: Goridis
authors.forename: B R
authors.initials: BR
authors.lastname: Jordan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005600:Fragile X Syndrome / Q000235:genetics; D005796:Genes; D008040:Genetic Linkage; D006153:Guanosine Diphosphate / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping; D012168:Retinal Pigments / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014960:X Chromosome
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D007136:Immunoglobulins; D012168:Retinal Pigments; D006153:Guanosine Diphosphate