Cutaneous pigmented melanocytic tumor in a mouse treated with psoralen plus ultraviolet A radiation.
A pigmented melanocytic tumor was induced on the treated site of a C3H/HeN female mouse given repeated topical applications of 8-methoxy-psoralen and subsequent exposures to ultraviolet A radiation (PUVA) over a 7-month period. The tumor invaded the subcutaneous tissue and muscle but produced no distant metastases. To our knowledge, this is the first report suggesting a direct relationship between PUVA treatment and the induction of cutaneous melanocytic tumor in mice.
Alcalay
J
J
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Bucana
C
C
Kripke
M L
ML
D000818:Animals; D005260:Female; D008544:Melanocytes / Q000648:ultrastructure*; D008545:Melanoma / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008854:Microscopy, Electron; D011701:PUVA Therapy / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology