title: Brainstem auditory-evoked response in the rat. Normative studies, with observations concerning the effects of ossicular disruption.
abstract: Six young adult Sprague-Dawley rats were unilaterally cochleotomized, Brain-stem auditory-evoked responses (BAERs) to clicks and to 1-, 2-, 4-, 8- and 16-kHz tone bursts were obtained. In addition, response thresholds were estimated before and after ossicular disruption in the noncochleotomized ear of 4 animals. With increasing tone burst frequency, there was a decrease in BAER peak latencies as well as a decrease in threshold. With increasing click and tone burst intensity, there was a decrease in peak latencies and an increase in peak amplitudes. BAER peak latency/intensity functions to click stimuli ranged from -.013 to -.018 ms/dB. With increasing tone burst frequency there was a decrease in the slope of the latency/intensity function. Following ossicular disruption, BAER thresholds to clicks were elevated by an average of 49 dB. Threshold shifts to tone burst stimuli were smallest for 1- and 2-kHz tone bursts (35-36 dB) and increased with increasing frequency up to a maximum of 65 dB for 16-kHz tone bursts.
authors.affiliation: Department of Communication Disorders, Boston University, Mass.
authors.forename: R
authors.initials: R
authors.lastname: Burkard
authors.forename: M
authors.initials: M
authors.lastname: Feldman
authors.forename: H F
authors.initials: HF
authors.lastname: Voigt
mesh_terms: D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D004429:Ear Ossicles / Q000502:physiology*; D004569:Electroencephalography / Q000295:instrumentation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D008144:Loudness Perception / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted