title: Streptokinase therapy for extensive venous thromboses in a patient with severe ulcerative colitis.
abstract: Thromboembolic disease is a known complication of patients with inflammatory bowel disease and often is associated with increased morbidity and mortality. In a patient with severe ulcerative colitis, extensive venous thromboses developed in three extremities. Despite active bleeding in the lower gastrointestinal tract, he was successfully managed preoperatively with infusions of streptokinase followed by full-dose heparinization. During the 48 hours he received streptokinase, his venous thromboses resolved dramatically. Within 2 weeks after admission, he underwent an uneventful proctocolectomy in conjunction with an ileoanal anastomosis.
authors.affiliation: Department of Internal Medicine, Mayo Clinic Jacksonville, FL 32224.
authors.forename: J H
authors.initials: JH
authors.lastname: Van Woert
authors.forename: R C
authors.initials: RC
authors.lastname: Thompson
authors.forename: J R
authors.initials: JR
authors.lastname: Cangemi
authors.forename: P P
authors.initials: PP
authors.lastname: Metzger
authors.forename: J L
authors.initials: JL
authors.lastname: Blackshear
authors.forename: C R
authors.initials: CR
authors.lastname: Fleming
mesh_terms: D000328:Adult; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000150:complications* / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D013300:Streptokinase / Q000627:therapeutic use*; D013350:Subclavian Vein; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000188:drug therapy* / Q000209:etiology; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D013300:Streptokinase