title: [The antitoxic function of the liver in D-galactosamine poisoning].
abstract: Two intragastric administrations of 500 mg/kg of D-galactosamine reduce the RNA and the cytochrome P-45, and b5 content in the hepatic microsomes of rats; inhibit the activity of aminopyrine-N-demethylase, hexobarbital hydroxylase, aniline-p-hydroxylase, and glutathione-S-transferase; reduce the rate of NADP.H and NAD.H oxidation; accelerate inactivation of cytochrome P-450 to cytochrome P-420; reduce the number of points of hexobarbital binding with N-octilamine, though increase the hemoprotein affinity to these substrates. Destruction of the nucleus, endoplasmic reticulum, and mitochondria occurs in the hepatocytes of D-galactosamine poisoned rats.
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovskiĭ
authors.forename: I M
authors.initials: IM
authors.lastname: Sedykh
authors.forename: T P
authors.initials: TP
authors.lastname: Novozheeva
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000187:drug effects / Q000502:physiology; D005688:Galactosamine / Q000493:pharmacokinetics / Q000506:poisoning*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
chemical_list: D005688:Galactosamine
vernacular_title: Antitoksicheskaia funktsiia pecheni pri intoksikatsii D-galaktozaminom.