Comparative toxicity of coniine, an alkaloid of Conium maculatum (poison hemlock), in chickens, quails, and turkeys.
Coniine, an alkaloid of Conium maculatum (poison hemlock), was administered by gavage to immature chickens, quails, and turkeys at 0, 25, 50, and 100 mg/kg body weight. At 25 mg coniine/kg body weight, clinical signs were observed only in quails (2/10) and consisted of excitement, depression, hypermetria, seizures, opisthotonos, and flaccid paralysis. Chickens (9/10) and quails (8/10) dosed at 50 mg/kg body weight were affected, and several birds of each species died (2/10 and 5/10, respectively). Turkeys (7/10) were affected only when dosed at 100 mg/kg body weight, and quails (6/10), turkeys (4/10), and chickens (10/10) died at this dose. There were no gross or microscopic lesions. Coniine was detected in skeletal muscle and liver of birds dying after ingestion and was present in some survivors 7 days post-treatment.
Frank
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Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907.
Reed
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D000470:Alkaloids / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D002645:Chickens; D003088:Colinus; D008401:Gas Chromatography-Mass Spectrometry; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010880:Piperidines; D011201:Poultry Diseases / Q000139:chemically induced*; D011784:Quail; D011897:Random Allocation; D012639:Seeds; D014422:Turkeys
D000470:Alkaloids; D010880:Piperidines; C007112:coniine