Aminoglutethimide enzyme induction: pharmacological and endocrinological implications.
Aminoglutethimide is an aromatase inhibitor that is successfully used for endocrine treatment of advanced breast cancer. This drug also stimulates the activity of hepatic mixed-function oxidases, increasing the metabolism of several drugs, including warfarin, digitoxin, antipyrine and theophylline. It also increases the plasma clearance rate of oestrone sulphate. As this oestrogen may be an important substrate for tumour cells, stimulation of oestrone sulphate metabolism may be a component of the mechanism of action of aminoglutethimide.
Lønning
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PE
Department of Therapeutic Oncology and Radiophysics, Haukeland University Hospital, Bergen, Norway.
D000616:Aminoglutethimide / Q000494:pharmacology* / Q000627:therapeutic use; D000983:Antipyrine / Q000493:pharmacokinetics; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D004074:Digitoxin / Q000493:pharmacokinetics; D004347:Drug Interactions; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D013806:Theophylline / Q000493:pharmacokinetics; D014859:Warfarin / Q000493:pharmacokinetics
D047072:Aromatase Inhibitors; D004967:Estrogens; D000616:Aminoglutethimide; D014859:Warfarin; D013806:Theophylline; D004074:Digitoxin; D000983:Antipyrine