[The antitoxic function of the liver in D-galactosamine poisoning].
Two intragastric administrations of 500 mg/kg of D-galactosamine reduce the RNA and the cytochrome P-45, and b5 content in the hepatic microsomes of rats; inhibit the activity of aminopyrine-N-demethylase, hexobarbital hydroxylase, aniline-p-hydroxylase, and glutathione-S-transferase; reduce the rate of NADP.H and NAD.H oxidation; accelerate inactivation of cytochrome P-450 to cytochrome P-420; reduce the number of points of hexobarbital binding with N-octilamine, though increase the hemoprotein affinity to these substrates. Destruction of the nucleus, endoplasmic reticulum, and mitochondria occurs in the hepatocytes of D-galactosamine poisoned rats.
Vengerovskiĭ
A I
AI
Sedykh
I M
IM
Novozheeva
T P
TP
Saratikov
A S
AS
D000818:Animals; D001711:Biotransformation / Q000187:drug effects / Q000502:physiology; D005688:Galactosamine / Q000493:pharmacokinetics / Q000506:poisoning*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats
D005688:Galactosamine
Antitoksicheskaia funktsiia pecheni pri intoksikatsii D-galaktozaminom.