title: Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences.
abstract: Theoretical search and selection criteria for putative fusion peptides of enveloped viruses are proposed. Arenavirus fusion peptides are predicted on the basis of computer-assisted analysis of amino acid sequences of arenavirus envelope proteins and elements of their secondary and tertiary structure. Accordingly, two regions of GP2 surface protein from 5 viruses of Arenaviridae family have been detected with properties typical of fusion peptides of other enveloped viruses. One region, named peptide IV, located at the N-terminus of the GP2 protein, is followed by the other region or peptide V, more likely candidate for the arenavirus fusion peptide.
authors.affiliation: Department of Special Pathogens, Byelorussian Research Institute of Epidemiology and Microbiology, Minsk, U.S.S.R.
authors.forename: S E
authors.initials: SE
authors.lastname: Glushakova
authors.forename: I S
authors.initials: IS
authors.lastname: Lukashevich
authors.forename: L A
authors.initials: LA
authors.lastname: Baratova
mesh_terms: D000595:Amino Acid Sequence; D001116:Arenaviridae; D007836:Lassa virus; D008562:Membrane Glycoproteins / Q000648:ultrastructure; D008969:Molecular Sequence Data; D010455:Peptides; D011487:Protein Conformation; D014759:Viral Envelope Proteins / Q000648:ultrastructure; D014760:Viral Fusion Proteins / Q000648:ultrastructure
chemical_list: D008562:Membrane Glycoproteins; D010455:Peptides; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins