Deficiency of methionine synthesis enzyme activity in ascites tumor cells.
Betaine-homocysteine- and S-adenosylmethionine-homocysteine-methyltransferases which catalyze synthesis of methionine from homocysteine are absent in tumor cells such as mouse Ehrlich ascites tumor cells and rat hepatoma AH-109A ascites cells.
Shimizu
K
K
Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Abe
M
M
Tsukada
K
K
D000818:Animals; D050940:Betaine-Homocysteine S-Methyltransferase; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D002855:Chromatography, Thin Layer; D050904:Homocysteine S-Methyltransferase; D008297:Male; D008715:Methionine / Q000096:biosynthesis*; D008780:Methyltransferases / Q000378:metabolism*; D051379:Mice; D014407:Tumor Cells, Cultured
D008715:Methionine; D008780:Methyltransferases; D050904:Homocysteine S-Methyltransferase; D050940:Betaine-Homocysteine S-Methyltransferase; C494549:Bhmt protein, mouse