Subcellular localization of blood group substances ABH in human salivary glands.
We investigated the subcellular localization of ABH antigens in human submandibular, sublingual, and buccal glands by applying a post-embedding immunogold method using monoclonal antibodies specific for A, B, and H antigens. In most glands the immunoreactivity was usually restricted to mucous cells, in which only secretory granules and sometimes Golgi cisternae were specifically labeled. A and B antigens were demonstrated only in the glands of type A, B, and AB subjects, while H antigen was visualized in glands from individuals of all blood types. Moreover, differences were observed in the relative distribution of ABH antigens, depending on the type of gland.
Cossu
M
M
Dipartimento di Citomorfologia, Universita' di Cagliari, Italia.
Riva
A
A
Lantini
M S
MS
D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D002610:Cheek; D003594:Cytoplasmic Granules / Q000032:analysis; D006056:Golgi Apparatus / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D009093:Mucus / Q000166:cytology; D012469:Salivary Glands / Q000276:immunology / Q000648:ultrastructure*; D013361:Sublingual Gland / Q000276:immunology / Q000648:ultrastructure; D013363:Submandibular Gland / Q000276:immunology / Q000648:ultrastructure
D000017:ABO Blood-Group System