[Fatal fulminant hepatitis in 2 women taking toloxatone (Humoryl)].
We report two cases of fulminant hepatitis which might be due to toloxatone, a new type-A monoamine oxidase inhibitor. Hepatitis occurred 20 days after the beginning of toloxatone administration in the first case and 138 days after the reintroduction of treatment in the second case. Clinical features included vomiting and jaundice, followed by asterixis and coma. Histologically, hepatic cell necrosis was predominant in the centrilobular area in the first case, and affected the entire lobule in the second case. Both patients died despite emergency liver transplantation.
Pateron
D
D
Service d'Hépatologie, (INSERM U 24), Hôpital Beaujon, Clichy.
Babany
G
G
Hadengue
A
A
Delafosse
B
B
Degott
C
C
Sylvain
C
C
Larrey
D
D
Benhamou
J P
JP
D000208:Acute Disease; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D010080:Oxazoles / Q000009:adverse effects*; D023303:Oxazolidinones; D013997:Time Factors
D000928:Antidepressive Agents; D010080:Oxazoles; D023303:Oxazolidinones; C010798:toloxatone
Hépatites fulminantes mortelles chez deux femmes prenant de la toloxatone (Humoryl).