Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats.
Pyridino [1,2-a] imidazo [5,4-b] indole (Compound 1) has been reported previously as an antihypertensive agent. Parenteral introductions of Compound 1 in spontaneously hypertensive rats (SHR) and in normotensive dogs have been found to reduce systolic blood pressure (SBP) in those animal models. Later studies have shown cholinomimetic effects of Compound 1 in animal tissue preparations and in live animals. Our experiments showed that daily oral administration of Compound 1 minimized the development of hypertensive nephrosclerosis and prevented premature death in male SHR. Compound 1 also potentiated cholinergic activity in isolated rabbit hearts. It is suggested that cholinergic vasodilation by Compound 1 is responsible for the hypotensive effect and prevention of nephrosclerosis in SHR.
Adhikary
P K
PK
Department of Pathology, Meharry Medical College, Nashville, TN 37208.
Sen
S K
SK
Maleque
M A
MA
D000818:Animals; D001921:Brain / Q000473:pathology; D006973:Hypertension / Q000150:complications*; D007093:Imidazoles / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000473:pathology; D009400:Nephrosclerosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D010277:Parasympathomimetics; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D014665:Vasodilator Agents
D007093:Imidazoles; D007211:Indoles; D010277:Parasympathomimetics; D011725:Pyridines; D014665:Vasodilator Agents; C063990:pyridino(1,2-a)imidazo(5,4-b)indole