title: High-density lipoprotein subfractions, apolipoproteins and antipyrine clearance in normal subjects.
abstract: Serum high density lipoprotein (HDL) subfractions HDL2 and HDL3, apolipoproteins, and plasma antipyrine clearance (AP-CL) rate, an index of liver microsomal enzyme activity, were determined in 21 healthy subjects. High HDL cholesterol and HDL2 cholesterol concentrations and HDL cholesterol/cholesterol and HDL2/HDL3 cholesterol ratios were associated with high AP-CL. Phenobarbital enhanced antipyrine elimination and increased the apolipoprotein A-I/A-II ratio. Subjects who had high AP-CL had a more antiatherogenic HDL subfraction and apolipoprotein profile than those with low AP-CL.
authors.affiliation: Department of Medicine, University of Oulu, Finland.
authors.forename: P V
authors.initials: PV
authors.lastname: Luoma
authors.forename: A
authors.initials: A
authors.lastname: Rautio
authors.forename: J
authors.initials: J
authors.lastname: Stengård
authors.forename: E A
authors.initials: EA
authors.lastname: Sotaniemi
authors.forename: J
authors.initials: J
authors.lastname: Marniemi
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol; D000983:Antipyrine; D010634:Phenobarbital