Determination of warfarin in drinking water by high-performance liquid chromatography after solid-phase extraction.
A method for the determination of 0.1 micrograms/l of warfarin in drinking water involving concentration by solid-phase extraction is described. A 1000-ml volume of drinking water is aspirated through a solid-phase extraction column and warfarin is eluted to 1.0 ml. The eluate is analysed by reversed-phase high-performance liquid chromatography with UV detection. The detection limit is 0.02 micrograms/l. Recoveries of greater than 90% were obtained when tap water was spiked with warfarin.
Dalbacke
J
J
Analytical and Quality Development Department, Gacell Laboratories AB, Malmö, Sweden.
Dahlquist
I
I
Persson
C
C
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D014466:Ultraviolet Rays; D014859:Warfarin / Q000032:analysis*; D014867:Water / Q000032:analysis*; D014881:Water Supply / Q000032:analysis
D014867:Water; D014859:Warfarin