title: The efficacy of high dose inhaled budesonide in replacing oral corticosteroid in Asian patients with chronic asthma.
abstract: We studied 22 Asian patients with steroid dependent asthma. Using a clinical approach to the addition of high dose inhaled budesonide and tapering of systematic steroid, we were able to substitute 5 to 20 mg prednisolone with 800 micrograms per day of inhaled budesonide in all patients. There was also a greater reduction in nocturnal symptoms and awakenings and a smaller overnight fall in PEFR during treatment with budesonide than with prednisolone. Inhaled budesonide was an effective long term substitute for prednisolone in chronic asthma.
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: W C
authors.initials: WC
authors.lastname: Tan
authors.forename: T B
authors.initials: TB
authors.lastname: Chan
authors.forename: T K
authors.initials: TK
authors.lastname: Lim
authors.forename: E C
authors.initials: EC
authors.lastname: Wong
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D044466:Asian People; D001249:Asthma / Q000188:drug therapy* / Q000208:ethnology / Q000503:physiopathology; D019819:Budesonide; D002908:Chronic Disease; D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011282:Pregnenediones / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D011282:Pregnenediones; D019819:Budesonide; D011239:Prednisolone