[The effect of galbanic acid on the course of experimental hepatitis].
Administration of galbanic acid isolated from the roots of Ferula kopetdaghensis Eug. Kor. to rats orally in a dose of 50 mg/kg was found to improve the course of toxic hepatitis induced by fourfold subcutaneous injections of a 50% oil solution of CCl4. Galbanic acid produced much more earlier than in control normalization of the activity of the enzymes alanine- and aspartataminotransferase in blood serum, increased glycogen content and improved the parameters of the redox potential of lactic acid-pyruvic acid system in the liver. Galbanic acid exerted the antioxidant effect. In the animals with a developed hepatitis receiving galbanic acid there was a more rapid restoration of intensity of bile secretion, synthesis of bile acids and bilirubin, cholesterol excretion as compared with control.
Syrov
V N
VN
Khushbaktova
Z A
ZA
Nabiev
A N
AN
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000032:analysis / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D003374:Coumarins / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005309:Ferula; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal; D010947:Plants, Toxic; D051381:Rats; D013997:Time Factors
D003374:Coumarins; C048972:galbanic acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vliianie gal'banovoĭ kisloty na techenie éksperimental'nogo gepatita.