[Invasive fungal infections in hematologic malignancies--a retrospective study of 61 autopsied cases].
In a review of 61 consecutive autopsy cases with a hematologic malignancy, said cases extending from April, 1984 to August, 1989, 34 cases were documented to have had an invasive fungal infection. The highest rate of incidence was found in various leukemia cases (69 to 100%), followed by those who had had a malignant lymphoma (50%) and a multiple myeloma (33%). Cultures from autopsy materials that determined the presence of a fungus were positive in 21 cases, including 13 cases of candidiasis, 8 cases of aspergillosis, and 2 cases of geotrichosis. The most frequent site of the fungal infection was in the lungs (76%), followed by the GI tract, the kidneys, the liver, and the spleen. Of 36 cases that had been treated with an empiric antifungal therapy, an invasive fungal infection was documented in 22 cases, half of them being fatal. In contrast, of 20 cases that had not received any antifungal treatment prior to death, an invasive fungal infection was found in 8 cases and three of these were fatal.
Kuzuyama
Y
Y
3rd Dept. of Int. Med., Kyoto First Red Cross Hospital.
Fujii
H
H
Kitagawa
Y
Y
Yashige
H
H
Horishi
H
H
Suyama
Y
Y
Miyoshi
M
M
D001228:Aspergillosis / Q000209:etiology*; D001230:Aspergillus / Q000302:isolation & purification; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000209:etiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D015458:Leukemia, T-Cell / Q000150:complications; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D012189:Retrospective Studies