Association between acute lymphoblastic leukemia and partial IgA deficiency in a young man--a family study.
We report on an unusual association between partial IgA deficiency and acute lymphoblastic leukemia in a young man. We also report results of the family study of immunoglobulin levels, sIgA B cells, in vitro IgA synthesis and molecular analysis of the structural C alpha genes. The IgA deficiency was present at diagnosis of leukemia prior to any therapy. The indirect arguments for a preexisting IgA deficiency are the absence of improvement of the IgA level during complete remission and especially the finding of a similar partial IgA deficiency in a sister who shared the same HLA haplotype, had a low percentage of sIgA B cells and decreased in vitro IgA production. The mother, who had a normal IgA serum level also had decreased in vitro IgA synthesis. No major structural C alpha gene defect was found. The relationship between acute lymphoblastic leukemia and IgA deficiency remains to be elucidated.
Chevailler
A
A
Laboratoire d'Immunopathologie, CHU, Angers, France.
Ifrah
N
N
Monteiro
R C
RC
Keyeux
G
G
Renier
G
G
Lefranc
M P
MP
Lesavre
P
P
Hurez
D
D
D000293:Adolescent; D000328:Adult; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000235:genetics; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
D006680:HLA Antigens; D007070:Immunoglobulin A