title: Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration.
abstract: A simple, rapid and sensitive electron-capture gas chromatographic method has been developed for the simultaneous determination of chloral hydrate, trichloroethanol and trichloroacetic acid in biological fluids. The described method is applicable to single-dose pharmacokinetic studies of chloral hydrate in the adult. The method also meets the important requirement of using very small sample volumes and is sufficiently sensitive and reliable for disposition studies in the neonate.
authors.affiliation: College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
authors.forename: D K
authors.initials: DK
authors.lastname: Gorecki
authors.forename: K W
authors.initials: KW
authors.lastname: Hindmarsh
authors.forename: C A
authors.initials: CA
authors.lastname: Hall
authors.forename: D J
authors.initials: DJ
authors.lastname: Mayers
authors.forename: K
authors.initials: K
authors.lastname: Sankaran
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000378:metabolism; D002697:Chloral Hydrate / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D006801:Humans; D007223:Infant; D008297:Male; D014238:Trichloroacetic Acid / Q000493:pharmacokinetics
chemical_list: D002697:Chloral Hydrate; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol