Dietary and pharmacological control of estradiol metabolism in humans.
Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable hormonal consequences have thus far been found in response to the modification of 2-hydroxylation. This approach offers promise as a method for specifically altering the risk for diseases associated with either too little estrogen (osteoporosis) or too much estrogen (breast and uterine cancer).
Michnovicz
J J
JJ
Rockefeller University, New York, New York 10021.
Bradlow
H L
HL
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007211:Indoles / Q000494:pharmacology; D008593:Menopause; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D010947:Plants, Toxic; D012907:Smoking; D039181:Steroid 16-alpha-Hydroxylase; D014026:Nicotiana
D007211:Indoles; D004958:Estradiol; D002927:Cimetidine; D003577:Cytochrome P-450 Enzyme System; C016517:indole-3-carbinol; D039181:Steroid 16-alpha-Hydroxylase