Antagonism of estrogen- and antiestrogen-induced uterine complement component C3 expression by ICI 164,384.
The uterus of the immature rat synthesizes and secretes complement component C3 in response to estradiol treatment. This response occurs in the uterine epithelial cells and is also stimulated by several antiestrogens including tamoxifen and LY117018. The administration of a new antiestrogen ICI 164,384 blocked the estradiol as well as the antiestrogen-stimulated increases in uterine weight, epithelial cell height, C3 synthesis and C3 mRNA. ICI 164,384 demonstrated no agonist properties in terms of epithelial cell response as determined by C3 expression.
Galman
M S
MS
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104.
Sundstrom
S A
SA
Lyttle
C R
CR
D000818:Animals; D003176:Complement C3 / Q000096:biosynthesis* / Q000235:genetics; D004847:Epithelial Cells; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D009929:Organ Size; D053284:Polyunsaturated Alkamides; D011759:Pyrrolidines / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013629:Tamoxifen / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology; D014599:Uterus / Q000033:anatomy & histology / Q000276:immunology*
D003176:Complement C3; D004965:Estrogen Antagonists; D053284:Polyunsaturated Alkamides; D011759:Pyrrolidines; D012333:RNA, Messenger; D013876:Thiophenes; D013629:Tamoxifen; D004958:Estradiol; C025430:LY 117018; C051781:ICI 164384