Mast cell degranulating peptide induces the expression of the c-fos proto-oncogene in hippocampus.
The intrahippocampal injection of the mast cell degranulating (MCD) peptide, a bee venom component acting on the K+ channel, results in the appearance of the proto-oncogene c-fos mRNA in the ipsi- and contralateral hippocampus of the treated animals without generating convulsions. This MCD-induced transcriptional event is discussed in terms of cellular plasticity since MCD peptide is known to induce long-term potentiation.
Séquier
J M
JM
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France.
Lazdunski
M
M
D000818:Animals; D015870:Gene Expression / Q000187:drug effects*; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism*; D007267:Injections; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011519:Proto-Oncogenes / Q000187:drug effects*; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes; D014158:Transcription, Genetic
D010455:Peptides; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; C008331:mast cell degranulating peptide