title: Vitrectomy in eyes at risk for macular hole formation.
abstract: Fifteen eyes believed to be at increased risk for macular hole formation underwent vitrectomy in an attempt to prevent macular hole formation. Full-thickness macular holes have not developed in 10 of 11 eyes with stage 1 macular holes. Four eyes were noted to have small full-thickness foveal defects (stage 2 macular holes) at the time of vitrectomy. Two of the four eyes have not progressed to macular hole formation and have 20/25 visual acuity. All patients have been followed for a minimum of 13 months (median, 18 months). The 12 eyes that have not experienced macular hole formation have had a significant (P less than 0.001) improvement in vision with seven (58%) attaining visual acuity of 20/25 or better. The postoperative foveal electroretinogram (ERG) amplitude was higher than the preoperative amplitude in five of the six eyes tested.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical School, Dallas.
authors.forename: B F
authors.initials: BF
authors.lastname: Jost
authors.forename: W L
authors.initials: WL
authors.lastname: Hutton
authors.forename: D G
authors.initials: DG
authors.lastname: Fuller
authors.forename: A
authors.initials: A
authors.lastname: Vaiser
authors.forename: W B
authors.initials: WB
authors.lastname: Snyder
authors.forename: G E
authors.initials: GE
authors.lastname: Fish
authors.forename: R
authors.initials: R
authors.lastname: Spencer
authors.forename: D G
authors.initials: DG
authors.lastname: Birch
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012167:Retinal Perforations / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D012307:Risk Factors; D014792:Visual Acuity; D014821:Vitrectomy