Red blood cell polyamine level changes following heart transplantation in man.
Follow-up of orthotopic heart transplanted patients has revealed the existence of abnormally high red blood cell (RBC) spermidine (Spd) levels during the first two months after surgical procedure (A-period). From the third month after heart transplantation (B-period), RBC Spd concentrations went back to normal values in early cardiac rejection (ECR) patients. During A- and B-periods, significantly higher Spd levels and Spd/Spm ratios were observed in late cardiac rejecting (LCR) patients than in ECR ones. The lack of a direct relationship between the histological grade of rejection and RBC Spd levels leads us to consider these polyamine blood levels as a new biological instrument in the diagnosis of heart rejection.
Unité de Biologie Cellulaire, CNRS SDI, Rennes, France.
J P
JP
Moulinoux
V
V
Quemener
J
J
Ollitrault
N A
NA
Khan
R
R
Havouis
M P
MP
Ramée
A
A
Leguerrier
C
C
Rioux
Y
Y
Logeais
D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D008297:Male; D013095:Spermidine / Q000096:biosynthesis*; D013096:Spermine / Q000096:biosynthesis*
D013096:Spermine; D013095:Spermidine