Sodium current and gating current experiments on the node of Ranvier.
Sodium tail currents of the frog node of Ranvier were recorded at different postpulse potentials. Inactivation was inhibited with chloramine-T. At E greater than -60 mV the tail currents decayed with two time constants, tau 1 and tau 2, reflecting presumably the turning-off and the inactivation of the sodium permeability. In the potential range -42 to -12 mV tau 1 (thought to equal tau m off) was not significantly different from the time constant of the turning-on of sodium activation m, tau m on. Similarly, no significant difference between tau on and tau off of the gating current was found if both were measured at the same potential.
Meves
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D000818:Animals; D002700:Chloramines / Q000494:pharmacology; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D008564:Membrane Potentials; D011893:Rana esculenta; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology*; D012964:Sodium / Q000502:physiology*; D013997:Time Factors; D014105:Tosyl Compounds
D002700:Chloramines; D007473:Ion Channels; D014105:Tosyl Compounds; C016300:chloramine-T; D012964:Sodium