Treatment alternatives in advanced testicular cancer.
Advanced testicular cancer is best treated with combination platinum based chemotherapy as primary therapy. If there is only moderate tumor bulk at presentation, many patients will achieve a complete remission and have no evidence of disease thereafter. Those with more bulky tumor who obtain a partial remission should then have residual tumor completely resected by surgery. This effectively re-stages the patient, provides therapeutic benefit to many and determines the need for additional chemotherapy. If carcinoma is found in the resected specimen, further "salvage" chemotherapy is required. If the resection is grossly complete even this group can obtain survival in the majority of cases.
Donohue
J P
JP
Rowland
R G
RG
D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009367:Neoplasm Staging; D011183:Postoperative Complications; D011860:Radiography, Abdominal; D012187:Retroperitoneal Space; D013736:Testicular Neoplasms / Q000601:surgery / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000627:therapeutic use; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin