Complex chromosome rearrangements involving 12q14 in two uterine leiomyomas.
Cytogenetic analysis of short-term cultures from 10 uterine leiomyomas revealed normal karyotypes in 8 and clonal complex chromosome rearrangements in 2 tumors. In both leiomyomas with clonal abnormalities, 12q14, but not 14q22-24, was involved in translocations with 1q43 in one tumor and with 12q24 in the other. Additional chromosome abnormalities were found in both cases: 1-5 rings and monosomy of chromosome 9 in case 1, and complex numerical and structural abnormalities of chromosomes 1, 6-8, 11, 13, 16, 17, and 22 in case 2. The consistent cytogenetic rearrangement of 12q14 in uterine leiomyomas, sometimes without concomitant 14q changes, indicates that a gene of critical importance for leiomyoma development may be found in this band.
Department of Cellular Physiology, Papanikolaou Research Center, Hellenic Anticancer Institute, Athens, Greece.
N
N
Pandis
G
G
Bardi
K
K
Sfikas
N
N
Panayotopoulos
A
A
Tserkezoglou
S
S
Fotiou
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology
D005819:Genetic Markers