bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.
Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.
C R
CR
Bartram
D001483:Base Sequence; D002904:Chromosomes, Human, 21-22 and Y; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010677:Philadelphia Chromosome; D012313:RNA / Q000032:analysis; D011995:Recombination, Genetic
D012313:RNA; D004247:DNA