A new model of experimental auto-immune myasthenia gravis.
Experimental auto-immune myasthenia gravis (EAMG) was observed in rabbits during the time course of immunization with an acetylcholine (ACh) conjugate: choline-glutaryl-protein. This synthesized antigenic determinant mimics the molecular structure of ACh. The presence of both anti-ACh and auto-anti-idiotypic antibodies was demonstrated. These latter antibodies recognized the ACh receptor, and could have been the triggering agents in this auto-immune condition. Clinical and electromyographic investigations confirmed the myasthenic symptomatology observed after immunization with the ACh conjugate.
Souan
M L
ML
Geffard
M
M
D000109:Acetylcholine / Q000276:immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D000939:Epitopes; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D011817:Rabbits
D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D000109:Acetylcholine