Variants of polyoma-transformed BHK21 cells unresponsive to fibronectin.
To investigate the relation between cell-substratum adhesion and cell-spreading we have isolated variants of anchorage-independent cells which fail to adhere to fibronectin. The variants are poorly adhesive both to fibronectin and serum, show dramatically altered morphology in culture and are unable to spread on any protein-coated surface yet tested.
J G
JG
Edwards
G
G
Campbell
N
N
Salama
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003208:Concanavalin A; D006224:Cricetinae; D005347:Fibroblasts; D005353:Fibronectins / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology; D007668:Kidney / Q000166:cytology; D008938:Mitosis; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology; D011120:Polyomavirus; D019096:Vitronectin
D003208:Concanavalin A; D005353:Fibronectins; D006023:Glycoproteins; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; D019096:Vitronectin