Abolition of the negative endocochlear potential as a consequence of the gentamicin-furosemide interaction.
The DC endocochlear potential and the AC cochlear potential in response to a 4 kHz tone were recorded in pigmented guinea pigs before and during ototoxic damage induced by sequential administration of the aminoglycoside antibiotic, gentamicin, and the loop diuretic, furosemide. Within 4 h significant diminution of the amplitude of the AC cochlear potential was accompanied by an almost complete abolition of the negative diffusion potential revealed by either furosemide administration or terminal anoxia. Thus, one of the effects of this interaction appears to involve a reduction in the potassium permeability of the cochlear partitions.
Lee
S J
SJ
Harpur
E S
ES
D000818:Animals; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D004347:Drug Interactions; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D006168:Guinea Pigs; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000378:metabolism; D013997:Time Factors
D005839:Gentamicins; D007473:Ion Channels; D005665:Furosemide; D011188:Potassium