[Effect of hyperthermic irrigation with bleomycin on prophylaxis of recurrence of bladder cancer].
Hyperthermic irrigation with Bleomycin of bladder at 43 approximately 44 degrees C for 3 hours after operation was performed in about 80 cases of bladder cancer from 1978, in our hospital. Bleomycin (90 mg) in 3,000 ml saline solution, was irrigated for 10 days postoperatively. No severe side effect was observed, while the complaint of a local side effect (bladder irritability) was made in 57.8%. Non-recurrence rate was calculated by the actual method, in 54 patients with bladder cancer which occurred initially. Non recurrence rate was 88.0% after 1 year, 73.3% after 2 and 3 years, and 63.5% after 4 years or more. Recurrence rate per 100 patient-month was 0.98. On the basis of our observations, it was concluded that hyperthermic irrigation with Bleomycin was useful for the prophylaxis for recurrence of bladder cancer after removal of the tumor.
K
K
Nishimura
O
O
Ogawa
N
N
Yoshimura
T
T
Nakagawa
M
M
Sasaki
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage*; D002291:Carcinoma, Papillary / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D007507:Therapeutic Irrigation; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*
D001761:Bleomycin