Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin.
Cutaneous pruritic effects of synthetic platelet activating factor (PAF-acether) and, in particular, its interference with dermal mast cells, were studied in human volunteers. Intradermal injections of 10-100 ng produced dose-dependent flare and itching responses. The cutaneous reactions were inhibited by local administration of the H1 antihistamine mepyramin. The cutaneous responses were also markedly reduced in histamine-depleted skin. These findings indicate that the cutaneous responses produced by PAF-acether were mediated via an indirect and mainly histamine-dependent mechanism.
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Fjellner
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Hägermark
D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy; D011738:Pyrilamine / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D010972:Platelet Activating Factor; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D011738:Pyrilamine