Role of secondary hyperparathyroidism and liver function in hyperamylasemia in chronic renal failure.
Elevated values of pancreatic-type amylase activity in serum were found in 59% of patients with liver cirrhosis not complicated with renal failure, in 67% of patients with chronic renal failure not complicated with hepatopathy and in 95% of patients with chronic renal failure complicated with hepatopathy. In all the three groups, a significant positive correlation was found between the pancreatic-type amylase and intestinal isoenzyme of serum alkaline phosphatase which is an asialoglycoprotein. However, in pancreatitis a prevalence of an increase in pancreatic-type amylase with respect to intestinal alkaline phosphatase was found. A multivariate analysis showed that in chronic renal failure not complicated with hepatopathy, and in chronic renal failure complicated with chronic liver disease, the changes in calcium homeostasis and also the liver disorder, respectively, contribute significantly to the above-normal values for pancreatic-type amylase.
Stĕpán
J J
JJ
Skrha
J
J
Havránek
T
T
Lachmanová
J
J
Hazuka
V
V
Tomásek
R
R
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000681:Amylases / Q000097:blood*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000097:blood; D007676:Kidney Failure, Chronic / Q000150:complications / Q000201:enzymology* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000201:enzymology; D008107:Liver Diseases / Q000150:complications* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D010281:Parathyroid Hormone / Q000097:blood; D012463:Saliva / Q000201:enzymology
D007527:Isoenzymes; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D000681:Amylases