Platelet function in hyperlipoproteinaemia.
A group of 53 healthy donors has been compared with another group of patients suffering from lipid metabolic disorders of Fredrickson type IIa (n = 14), IIb (n = 11) and IV (n = 21). In the course of three weeks the determinations have been carried out of lipid mechanism parameters, of Apoprotein B, of aggregation response upon ADP and adrenaline++ induction, of beta thromboglobulin, of heparin neutralizing activity, of malonyldialdehyde production upon N-ethylmaleimide stimulation and of the amount of circulating aggregates. In patients with HLP of IIa and IIb type a significant increase of plasmic beta thromboglobulin level was noted as well as shifts of other thrombocytic parameters towards higher platelet reactivity. The correlation between individual platelet parameters and parameters of lipid metabolism was statistically significant only in the case of cholesterol and malonyldialdehyde. A positive correlation of Apo B with BTG and with the aggregation response together with the observation of an increased Apo B concentration in normolipemic subjects with changed platelet reactivity, are indicative of an important role of Apo B during platelet activation in vivo.
Parízek
M
M
Parízková
M
M
Kubisz
P
P
D000328:Adult; D001059:Apoproteins / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D008875:Middle Aged; D010974:Platelet Aggregation; D014280:Triglycerides / Q000097:blood; D001620:beta-Thromboglobulin / Q000097:blood
D001059:Apoproteins; D008076:Cholesterol, HDL; D014280:Triglycerides; D001620:beta-Thromboglobulin; D008315:Malondialdehyde; D002784:Cholesterol