Monoclonal antibodies to human beta-interferon produced by adoptive transfer in irradiated mice.
Three murine anti-human beta-interferon (IFN-beta) monoclonal antibodies have been isolated following adoptive transfer of immune spleen cells. Adoptive transfer was used to increase the specific efficiency of the fusion. These antibodies have been used to define two epitopes on IFN-beta; the antiviral, antiproliferative, and immunomodulatory effects of IFN-beta are associated with one of these epitopes.
K J
KJ
Thompson
K M
KM
Dawson
J A
JA
Davies
C H
CH
Powell-Jones
S
S
Buckham
G J
GJ
O'Neill
K G
KG
McCullagh
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000378:metabolism*; D001667:Binding, Competitive; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis; D006801:Humans; D006822:Hybrid Cells; D007116:Immunization, Passive; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism*; D007457:Iodine Radioisotopes; D051379:Mice; D008807:Mice, Inbred BALB C / Q000528:radiation effects; D009500:Neutralization Tests; D011233:Precipitin Tests; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation*; D014185:Transplantation, Isogeneic; D014916:Whole-Body Irradiation
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000939:Epitopes; D007370:Interferon Type I; D007457:Iodine Radioisotopes