Identification of the principal receptor responsible for adsorptive endocytosis of a fucose-specific lectin from Aleuria aurantia in the rabbit retina.
The retinal uptake of the fucose-specific lectin from Aleuria aurantia was investigated in rabbit. Following intraocular injections of Aleuria lectin, the probe was taken up by retinal ganglion cells and rapidly transported at two distinct rates in the optic pathway, to reach the nerve terminals in the lateral geniculate body and superior colliculus [3]. In this study, it was found that adsorptive endocytosis of Aleuria lectin was mediated mainly by a glycoprotein of Mr 275,000.
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D000327:Adsorption; D000818:Animals; D001370:Axonal Transport; D004705:Endocytosis; D005829:Geniculate Bodies / Q000378:metabolism; D037102:Lectins / Q000378:metabolism*; D009411:Nerve Endings / Q000378:metabolism; D011817:Rabbits; D011975:Receptors, Mitogen / Q000302:isolation & purification*; D012160:Retina / Q000378:metabolism*; D013477:Superior Colliculi / Q000378:metabolism
D037102:Lectins; D011975:Receptors, Mitogen; C027112:fucose-binding lectin