Clinical experience in oral surgery with human fibrin sealant.
Fibrin sealant is a two-component product consisting in principle of fibrinogen and thrombin. When it is activated, fibrin (the clot) is formed. Being a natural product, the versatility of its use in the human body is great. No side-effects or complications have been described. It has been tested clinically in oral surgery and found to be very effective in the fixation of mucosal and skin grafts in the oral cavity; as a surgical dressing for the palate or on the lips; in osseous reconstruction after mixture with bone-chips; and finally in the treatment of chronic sclerotizing osteomyelitis of the mandible after the addition of metronidazole. It also has uses in many other fields of surgery.
Petersen
J K
JK
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D007611:Aprotinin / Q000627:therapeutic use*; D001672:Biocompatible Materials; D016025:Bone Transplantation; D002122:Calcium Chloride / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008336:Mandibular Diseases / Q000628:therapy; D009055:Mouth / Q000601:surgery*; D056948:Orthognathic Surgical Procedures; D010019:Osteomyelitis / Q000628:therapy; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin; D002122:Calcium Chloride