Enhancement by interferon of chicken splenocyte natural killer cell activity against Marek's disease tumor cells.
A non-immune natural killer-type cell population (NK) from 6-to 12-week old chickens was able to kill MSB-1 Marek's disease (MD) tumor cells in vitro; as measured by the 51Cr-release cytotoxicity assay. Removal of T cells, B cells, adherent cells, or any combination of the three populations of cells did not result in diminished levels of cytotoxicity of the remaining spleen cells against MSB-1 cells. The cytotoxicity of chicken NK cells could be rapidly augmented by polyinosinic-polycytidylic acid (poly I:C) and by the Cal 11914 strain of Newcastle disease virus (NDV), but not by the TCND strain of NDV which is not an interferon (IFN) inducer, indicating that IFN play a role in augmentation of the NK activity in chickens.
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D000818:Animals; D002645:Chickens; D003602:Cytotoxicity, Immunologic; D066298:In Vitro Techniques; D007372:Interferons / Q000276:immunology* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology*; D008380:Marek Disease / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology; D011070:Poly I-C / Q000494:pharmacology; D013154:Spleen / Q000276:immunology
D007372:Interferons; D011070:Poly I-C