Allergenic cross-reactivity among pollens of Urticaceae.
Common antigenic determinants have been observed between Parietaria and Urtica dioica pollen. The four Parietaria pollens selected (P. judaica, P. officinalis, P. lusitanica and P. mauritanica) are shown to possess a high allergenic homology. IgE-binding structures, homologous to the P. judaica main allergenic polypeptide (Pj10), were found in the other species by immunodetection. Monoclonal antibodies specific to the Pj10 polypeptide recognized proteins from the four Parietaria pollens. Skin prick test and RAST inhibition yielded results that also indicated a high allergenic cross-reactivity among these pollens, with homologous peptides bearing common antigenic and allergenic determinants. On the other hand, U. dioica pollen showed only a slight allergenic similarity to Parietaria. The potential allergenic activity of these pollens is discussed.
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AL
Corbí
C
C
Cortes
J
J
Bousquet
A
A
Basomba
A
A
Cistero
J
J
Garcia-Selles
G
G
d'Amato
J
J
Carreira
D000485:Allergens / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007073:Immunoglobulin E / Q000276:immunology; D010455:Peptides / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test; D012882:Skin Tests; D013045:Species Specificity
D000485:Allergens; D000911:Antibodies, Monoclonal; D000939:Epitopes; D010455:Peptides; D007073:Immunoglobulin E