Pulmonary changes at computed tomography in patients with testicular carcinoma treated with cis-platinum, vinblastine and bleomycin.
Computed tomography was performed before and after CVB therapy (cis-platinum, vinblastine, bleomycin) in 42 patients with metastatic testicular carcinoma. Twenty-one of these (3 symptomatic, 18 asymptomatic) developed subpleural pulmonary abnormalities which were streaky or reticular in 7, homogeneous with a broad base against pleura in 3 and had a mixed pattern in 11 patients. Histologic examination was obtained in 3 patients and showed fibrosis with no tumor tissue. Twelve patients with marked CVB induced abnormalities underwent repeat CT within 6 to 24 weeks. Changes disappeared spontaneously in 7, diminished in 3 and increased in 2 of these. Further conventional chest radiography of the latter two revealed complete regression of changes. Pulmonary lesions induced by CVB therapy should be kept in mind at follow-up so that an erroneous diagnosis of tumor progression is not made.
Lien
H H
HH
Brodahl
U
U
Telhaug
R
R
Holthe
H
H
Fosså
S D
SD
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003951:Diagnostic Errors; D004407:Dysgerminoma / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000000981:diagnostic imaging*; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects
D000970:Antineoplastic Agents; D001761:Bleomycin; D002945:Cisplatin; D014751:Vindesine