Invasion of erythrocytes in vitro by Plasmodium falciparum can be inhibited by monoclonal antibody directed against an S antigen.
A monoclonal antibody has been produced which binds to the heat stable S antigen present in the FCQ-27/PNG isolate of Plasmodium falciparum. This monoclonal antibody also inhibits the invasion in vitro of erythrocytes by malarial merozoites thus demonstrating that the S antigens of Plasmodium falciparum may be a target of protective immune responses.
Saul
A
A
Cooper
J
J
Ingram
L
L
Anders
R F
RF
Brown
G V
GV
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000953:Antigens, Protozoan / Q000276:immunology* / Q000502:physiology; D003001:Cloning, Molecular; D000939:Epitopes / Q000276:immunology; D004912:Erythrocytes / Q000469:parasitology; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D011994:Recombinant Proteins / Q000276:immunology / Q000502:physiology
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D000939:Epitopes; D011994:Recombinant Proteins; C047712:S-antigen, Plasmodium falciparum