Probable histamine liberation with atracurium. A case report.
An histaminoid reaction after the administration of thiopentone and atracurium is described. Serial blood sampling showed no evidence of complement activation. Intradermal testing 6 weeks later yielded a positive result with atracurium (1 in 1000), but not with thiopentone. The clinical course of the reaction and the subsequent investigations suggest a direct pharmacological liberation of histamine.
G G
GG
Lavery
M M
MM
Boyle
R K
RK
Mirakhur
D000293:Adolescent; D001279:Atracurium; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007428:Intradermal Tests; D007431:Intraoperative Complications / Q000209:etiology; D007546:Isoquinolines / Q000009:adverse effects*; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium