Enhancement of hypoxemia by atrial shunting in cystic fibrosis.
Patients with CF may develop hypoxemia which seems disproportionate to the degree of pulmonary disease. In a series of patients with CF and advanced pulmonary disease undergoing transesophageal echocardiography for the evaluation of cor pulmonale, eight of 15 patients were found to have atrial shunts through a stretched foramen ovale. To our knowledge, this is the first observation of intracardiac shunting in CF. This phenomenon may account for unexplained levels of cyanosis and worsening of hypoxemia with exercise, vasodilators, or PEEP and poses the threat of paradoxic emboli when central venous lines are used in these patients.
Department of Pediatrics, Hahnemann University, Philadelphia.
A
A
Davidson
K
K
Chandrasekaran
L
L
Guida
D S
DS
Holsclaw
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology; D004452:Echocardiography; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D008297:Male