Cellular differentiation.
Substantial evidence now points to DNA methylation playing a primary role in locking genes in the "off' condition. Specific hypomethylation events may be necessary but not sufficient for gene expression. 5-azacytidine is a useful drug to perturb DNA methylation patterns and determine the effects of these perturbations on gene expression.
Taylor
S M
SM
Jones
P A
PA
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism; D005786:Gene Expression Regulation; D008745:Methylation; D051379:Mice; D008809:Mice, Inbred C3H; D014280:Triglycerides / Q000378:metabolism
D000085:Acetates; D014280:Triglycerides; D004247:DNA; D004248:DNA (Cytosine-5-)-Methyltransferases; D001374:Azacitidine; D019342:Acetic Acid