[The uptake of 3H-serotonin by neural elements of the rat hypothalamus in ontogeny].
Development of serotoninergic system of rat hypothalamus has been studied. The level of its maturity was measured by specific absorption of 3H-serotonin by hypothalamus of fetuses (days 16-20 of intra-uterine development), newborn (9 days after birth) and adult rats. Inhibitors of specific serotonin capture by serotoninergic neural elements (cocaine, fluoxetin and cytalopram) were used in control experiments. Specific uptake of 3H-serotonin by hypothalamus was detected on day 16 of intra-uterine development. It increased twice by day 18 and remained unchanged until birth. No statistically significant increase of 3H-serotonin uptake was detected in newborn and adult animals.
Proshliakova
E V
EV
Ugriumov
M V
MV
Manukhin
B N
BN
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D015283:Citalopram / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D005333:Fetus; D005473:Fluoxetine / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists; D014316:Tritium
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D005473:Fluoxetine; D015283:Citalopram; D014316:Tritium; D012701:Serotonin; D003042:Cocaine
Zakhvat 3H-serotonina nervnymi élementami gipotalamusa krys v ontogeneze.