Decreased immunologic responsiveness following intensified vaginal immunization against urinary tract infection.
In an attempt to further increase the protective effect of vaginal immunization against urinary tract infections in Cynomolgus monkeys, the immunogen of killed E. coli was given more times, in larger amounts, and with the adjuvant MDP. Instead of increasing the protective effect, no protective effect on induced cystitis was observed. In addition, rises in urinary and serum immunoglobulins previously observed after vaginal immunization and induced cystitis were lessened. These observations appear to correspond with the classical concepts of immunologic unresponsiveness.
Department of Surgery (Urology), University of Wisconsin, Madison.
D T
DT
Uehling
W J
WJ
Hopkins
E
E
Balish
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D005260:Female; D007114:Immunization / Q000379:methods; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008252:Macaca fascicularis; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014621:Vagina / Q000276:immunology*
D001428:Bacterial Vaccines; D007136:Immunoglobulins; D015164:Vaccines, Inactivated; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D002097:C-Reactive Protein