Immunopathology associated with human lymphotropic retroviruses.
The human lymphocytotropic retroviruses, despite the fact that their immunopathology varies from acute immunodeficiency to leukemia, have several features in common: they are exogenous viruses isolated from mature T cells, especially T4+ T-cells; they preferentially infect mature T4+ T cells in vitro, although other kinds of cells can be infected (no pathologic effects have been associated with infection of nonlymphoid cells); they possess a reverse transcriptase with similar size and preference for Mg++; they have a unique pX sequence in their genome which codes for a protein which is responsible for trans-activation of viral and possibly cellular genes, and in vitro infection of some T cells induces either continuous proliferation or cytotoxicity which mimic the in vivo manifestations of the virus.
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Ruscetti
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology / Q000662:veterinary; D000818:Animals; D002455:Cell Division; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D017977:Deltaretrovirus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure; D005786:Gene Expression Regulation; D005814:Genes, Viral; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology* / Q000276:immunology; D007938:Leukemia / Q000209:etiology / Q000276:immunology*; D008992:Monkey Diseases / Q000209:etiology / Q000276:immunology; D011323:Primates / Q000382:microbiology; D012194:RNA-Directed DNA Polymerase / Q000502:physiology; D011971:Receptors, Immunologic / Q000032:analysis; D015375:Receptors, Interleukin-2; D011991:Receptors, Virus / Q000032:analysis; D012190:Retroviridae / Q000302:isolation & purification; D012192:Retroviridae Infections / Q000150:complications* / Q000276:immunology / Q000662:veterinary; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000382:microbiology; D014764:Viral Proteins / Q000502:physiology
D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D011991:Receptors, Virus; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase