The effect of food and water deprivation on post-stress analgesia in mice and levels of beta-endorphin and dynorphin in blood plasma and hypothalamus.
Pain sensitivity of food and/or water-deprived male mice was tested on a hotplate. The most pronounced analgesia ensued in animals given no food and water, and no food but water ad libitum, the least one in water-deprived mice. The magnitude of the rise in pain threshold depended on the duration of deprivation and was correlated with the increase in the blood plasma beta-endorphin level. In the hypothalamus beta-endorphin level increased after 72-h food deprivation only. The level of dynorphin remained unchanged. Naloxone (10 mg/kg) almost completely reversed food or water-deprivation induced analgesia.
Konecka
A M
AM
Sroczynska
I
I
Przewlocki
R
R
D000698:Analgesia; D000818:Animals; D004399:Dynorphins / Q000097:blood / Q000378:metabolism*; D004723:Endorphins / Q000097:blood / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D011863:Radioimmunoassay; D011930:Reaction Time; D012684:Sensory Thresholds / Q000187:drug effects; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors; D014868:Water Deprivation / Q000502:physiology; D001615:beta-Endorphin
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; D004399:Dynorphins