[Characteristics of isoniazid pharmacokinetics in the blood of patients with pulmonary tuberculosis with concomitant chronic Trematode infections].
Isoniazid pharmacokinetics was studied in 93 patients with pulmonary tuberculosis including 47 patients with concomitant chronicTrematode infection. After enteral administration of the drug its blood concentrations were shown to be low due to the decreased absorption function of the small intestine and impaired absorption and excretion functions of the hepatobiliary system. It was concluded that in such patients intramuscular administration of isoniazid was advisable.
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Korablev
D000293:Adolescent; D000328:Adult; D000368:Aged; D001682:Biological Availability; D002908:Chronic Disease; D006207:Half-Life; D006801:Humans; D007538:Isoniazid / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008109:Liver Diseases, Parasitic / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D014201:Trematode Infections / Q000097:blood / Q000150:complications*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D007538:Isoniazid
Osobennosti farmakokinetiki izoniazida v krovi bol'nykh tuberkulezom legkikh s soputstvuiushchimi khronicheskimi trematodozami.