The management of metastatic germ cell tumours and the clinical utility of lactate dehydrogenase estimations.
Forty-five patients with metastatic germ cell tumour were treated with chemotherapy. Complete remission was achieved in 63% of all cases and in 65% of patients whose primary tumour arose in the testis or ovary. Surgical resection of abdominal masses persisting after chemotherapy was performed in seven patients, two of whom were found to have persistent tumours. Twenty-seven of the 33 patients with teratoma originating in the gonads remain in complete remission. Total serum LDH activity was elevated in 28 of the patients with measurable disease. The increased LDH was not accompanied by significant alteration in other hepatic enzymes nor were hepatic metastases demonstrable in these patients. Fractionation of the LDH demonstrated that the increased LDH in these patients was located in either iso-enzymes 1 or fractions 1 + 2. Alteration of the serum LDH activity correlated with the response to therapy and warrants further study.
P G
PG
Gill
R
R
Abbott
A M
AM
Jones
D W
DW
Thomas
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000032:analysis; D004407:Dysgerminoma / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008479:Mediastinal Neoplasms; D010051:Ovarian Neoplasms; D013724:Teratoma / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D013736:Testicular Neoplasms; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D007770:L-Lactate Dehydrogenase