Serologic and immune responses to rabies virus during different human treatments with tissue culture and suckling mouse brain vaccines.
The antibody response to rabies virus was studied in twenty volunteers immunized with different schemes of suckling mouse brain and human diploid cell culture rabies vaccines. Throughout the study period, titers in serum neutralization and indirect fluorescent antibody tests, as well as the class of immunoglobulins with antirabies activity, varied in different individuals with the treatment scheme and the antigenic potency of the vaccine. The results suggest that measurement of the IgG class of antirabies antibodies, and possibly IgA as well, may be a more adequate criterion to assess the immunogenicity of rabies vaccines than the determination of SN titers alone.
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D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001921:Brain; D046508:Culture Techniques; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007136:Immunoglobulins / Q000032:analysis; D051379:Mice; D011818:Rabies / Q000276:immunology*; D011819:Rabies Vaccines / Q000276:immunology* / Q000627:therapeutic use
D000914:Antibodies, Viral; D000939:Epitopes; D007136:Immunoglobulins; D011819:Rabies Vaccines