[Immunocytochemical study of the spinal distribution of substance P, enkephalins, cholecystokinin and serotonin in amyotrophic lateral sclerosis].
Using immunocytochemical methods, a severe loss of substance P, but not of enkephalin, cholecystokinin and serotonin containing fibers was observed in lamina IX of the spinal cords from 4 amyotrophic lateral sclerosis cases. Substance P-fibers were decreased before degeneration of motoneurons. They were normal in the remaining spinal gray matter.
J
J
Schoenen
M
M
Reznik
P J
PJ
Delwaide
J J
JJ
Vanderhaeghen
D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism
D018377:Neurotransmitter Agents; D012701:Serotonin; D013373:Substance P; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D002766:Cholecystokinin
Etude immunocytochimique de la distribution spinale de substance P, des enképhalines, de cholécystokinine et de sérotonine dans la sclérose latérale amyotrophique.