[Results of the study of the activity of bone marrow nucleolar organizers in patients with multiple myeloma].
Data obtained from karyotyping and estimation of nucleolar organizer (NO) activity in bone marrow cells from 9 patients with multiple myeloma (MM) and from 8 donors are presented. Chromosomes of the 14th and 1st pairs in patients with MM are confirmed to be more frequently involved in rearrangements. It is proved that activity of NO in myeloma cells is rather high as compared to that of erythroid and granulocyte cells, that is associated with their participation in paraprotein synthesis.
Mamaev
N N
NN
Mamaeva
S E
SE
Ushakova
E A
EA
Liburkina
I L
IL
Pozniak
E I
EI
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D013194:Staining and Labeling
D005819:Genetic Markers
Rezul'taty izucheniia aktivnosti iadryshkovykh organizatorov kletok kostnogo mozga bol'nykh mnozhestvennoĭ mielomoĭ.