[The value of surgical staging in the early stages of ovarian carcinoma].
The value of surgery in early ovarian cancer was assessed in a retrospective analysis of prognostic factors in all 222 patients with primary stage I epithelial ovarian carcinoma treated in this department between 1975 and 1987. Only cellular differentiation grade (p less than 0.03) and surgical procedure - total abdominal hysterectomy, bilateral salpingo-oophorectomy +/- omentectomy vs. unilateral salpingo-oophorectomy - (p less than 0.02) were of significant influence on estimated survival (Cox model). All other factors (age, FIGO stage, integrity of the capsule, uni-vs. bilaterality, histology) were of no prognostic importance. Unilateral salpingo-oophorectomy without any additional staging reduces the 5-year survival probability (62% vs. 84%). Future prospective studies on adjuvant therapy must be based on exact staging during surgical management before randomisation. Determination of cellular differentiation is also essential.
Gynäkologisch-onkologische Arbeitsgruppe der I. Universitäts-Frauenklinik, Wien.
H
H
Salzer
P
P
Sevelda
H
H
Genger
S
S
Schmidl
U
U
Denison
M
M
Barrada
N
N
Vavra
H
H
Kucera
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D010052:Ovariectomy; D010533:Peritoneal Lavage; D012189:Retrospective Studies; D013997:Time Factors
Die Bedeutung der Staging-Operation bei den Frühstadien des Ovarialkarzinoms.