[Reassessment of the respective risks of anaphylaxis and histamine liberation with anesthetic substances].
A search of the French and English language literature of the last 20 years (1964-1984) yielded 975 cases of immediate anaphylactoid reactions due to anaesthetic drugs given parenterally. The accident mechanism was confirmed in only half the patients, and nearly always at a later date. The immunoallergological tests most often used in the diagnostic process were skin tests and Prausnitz-Küstner tests. Although all drugs could be responsible for an anaphylactic reaction, the greatest number of cases was due to muscle relaxants (51%) and hypnotic drugs (42.3%). The signs most often described were cutaneous, cardiovascular, respiratory and occasionally gastro-intestinal. Whilst hypnotic drugs were responsible for cutaneous signs, muscle relaxants gave cardiovascular signs. A past history of drug allergy was found in 37% of cases, and atopy in 38%; virtually all patients had already had one or more anaesthetics.
S
S
Boileau
M
M
Hummer-Sigiel
R
R
Moeller
N
N
Drouet
D000707:Anaphylaxis / Q000139:chemically induced*; D000758:Anesthesia / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects; D001569:Benzodiazepines / Q000009:adverse effects; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D009020:Morphine / Q000009:adverse effects; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects
D000777:Anesthetics; D014150:Antipsychotic Agents; D003473:Neuromuscular Nondepolarizing Agents; D001569:Benzodiazepines; D009020:Morphine; D013390:Succinylcholine
Réévaluation des risques respectifs d'anaphylaxie et d'histaminolibération avec les substances anesthésiologiques.