Carcinoma of the cervix with extensive endometrial and myometrial involvement.
Verrucous carcinoma is a rare variant of epidermoid carcinoma with distinct clinical and histopathologic features. To date, 31 cases have been reported in the cervix. They are typically slow-growing, locally invasive tumors with low potential for lymphatic metastasis and appear to be radioresistant. We report a case which is unusual in having endometrial and deep myometrial invasion. Electron microscopy, immunohistochemical stains, and DNA in situ hybridization studies failed to detect human papilloma virus particles but the oncogenic potential of the virus is not excluded.
Department of Pathology, New York Medical College-Metropolitan Hospital Center, New York 10029.
M
M
de Jesus
W
W
Tang
M
M
Sadjadi
A H
AH
Belmonte
T P
TP
Poon
D000368:Aged; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D004247:DNA; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009215:Myometrium / Q000473:pathology*; D009693:Nucleic Acid Hybridization; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D004247:DNA