The value of Doppler assessment of the uteroplacental circulation in predicting preeclampsia or intrauterine growth retardation.
Flow velocity waveforms of the uteroplacental arteries were analyzed at 20 and 24 weeks of gestation, by means of duplex pulsed Doppler ultrasonography, in 93 women at risk for preeclampsia or intrauterine growth retardation. The ability of an elevated resistance index to predict these conditions was tested. At 20 and 24 weeks an abnormal resistance index was significantly associated with intrauterine growth retardation but not with preeclampsia, with or without proteinuria. A low fetal abdominal circumference at 20 or 24 weeks or an increasing maternal plasma uric acid concentration at 24 weeks was as predictive as an elevated resistance index. In a second group of 43 women, screened in the same way, the only association was of an elevated resistance index at 20 weeks with intrauterine growth retardation. Although elevated resistance indices occur more commonly in women who develop intrauterine growth retardation and/or preeclampsia, the correlation is not close enough to be clinically useful as a screening test.
Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Headington, Oxford, England.
S L
SL
Jacobson
R
R
Imhof
N
N
Manning
V
V
Mannion
D
D
Little
E
E
Rey
C
C
Redman
D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D014463:Ultrasonography; D014527:Uric Acid / Q000097:blood; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance
D014527:Uric Acid