Medicinal protection with Chinese herb-compound against radiation damage.
Experiments were carried out on mice and the subjects irradiated for cancer therapy to evaluate the protective efficacy of a Chinese medicinal herb-compound (CMHC). The lethality and the degree of leucopenia caused by radiation in mice medicated with CMHC were significantly less in comparison with control mice (p less than 0.01 and p less than 0.001, respectively). CMHC significantly improved the WBC and the thrombocytes in irradiated workers (p less than 0.01 and p less than 0.001, respectively). The WBC count of 40 patients under radiotherapy while treated with CMHC recovered from 3450 +/- 77/c.mm to 5425 +/- 264/c.mm (p less than 0.001); whereas, in the control group, without any medication, the WBC count dropped significantly (p less than 0.001). Our results revealed the applicabilities of CMHC in protection against radiation damage in spaceflight and in other fields.
Zhang
R J
RJ
Laboratory of Environmental Medicine, Institute of Space Medico-engineering, Beijing, China.
Qian
J K
JK
Yang
G H
GH
Wang
B Z
BZ
Wen
X L
XL
D000818:Animals; D001216:Asparagine / Q000008:administration & dosage / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005960:Glucosides; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007970:Leukopenia / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D051379:Mice; D009369:Neoplasms / Q000532:radiotherapy; D010666:Phenylpropionates; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D011878:Radiotherapy / Q000009:adverse effects*; D012855:Sitosterols / Q000008:administration & dosage / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006490:Hemostatics; D010666:Phenylpropionates; D012855:Sitosterols; D001216:Asparagine; C028305:syringin; C011015:lyoniside