Evaluation of human cellular immune function in echinococcosis.
Forty nine individuals (11 patients with surgically proved hydatid disease, 23 individuals with non hydatid disease and 15 normal healthy adults) were investigated for specific and nonspecific cellular immune status using in vitro blast transformation assay. Patients with hydatid disease had suppressed cellular immune function to a nonspecific T-cell mitogen (PHA) when compared to the relevant controls. Hydatid antigen directly inhibited in vitro blast transformation from a concentration of 0.1 microgram protein/ml onwards in all the three groups of subjects, irrespective of whether they had hydatidosis or not. However, hydatid antigen did not act as a T-cell mitogen in our study.
Wattal
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Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar.
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004443:Echinococcosis / Q000276:immunology*; D004446:Echinococcus / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation
D000947:Antigens, Helminth