[Furosemide interaction with the prostaglandin and kallikrein-kinin systems of the kidneys].
Indomethacin (3 mg/kg, orally for 5 days) prevented the increase of blood flow in the internal zone of the renal cortical layer but failed to interfere with the increase of diuresis and sodium secretion produced by furosemide (2 mg/kg, subcutaneously) in anesthetized rats. Contrykal (6000 ED, subcutaneously) failed to alter the character of the hemodynamic changes in the renal cortex but enhanced the diuretic and natriuretic effects of furosemide. In unanesthetized rats indomethacin prevented creatinine urine excretion but didn't attenuate the diuretic and natriuretic effects of furosemide.
Kuz'min
O B
OB
Mikhaĭlenko
P V
PV
Kriukova
R A
RA
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004347:Drug Interactions; D005665:Furosemide / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000502:physiology*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007705:Kinins / Q000502:physiology*; D009318:Natriuresis / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects
D007705:Kinins; D011453:Prostaglandins; D005665:Furosemide; D007611:Aprotinin; D007610:Kallikreins; D007213:Indomethacin
Vzaimodeĭstvie furosemida s prostaglandinovoĭ i kallikrein-kininovoĭ sistemami pochek.