[Effect of 7S immunoglobulin substitution on the incidence and course of infection in cytostatic drug treated patients].
This retrospective analysis evaluates the effect of intravenously administered immunoglobulin against infections occurring during bone marrow depression after cancer chemotherapy in 85 children with leukemia and lymphoma. There was no statistical difference between patients with and without immunoglobulin administration neither when immunoglobulins were used prophylactically nor therapeutically in addition to antibodies during episodes of infection. Duration of fever, duration of antibiotic therapy, maximum of temperature, white blood cell counts, and kind of infections were comparable in 84 fever episodes in patients who had received immunoglobulin therapeutically and 69 fever episodes in patients who had not. This study supports the aspect that immunoglobulin administration does not have preventive or therapeutic efficacy on infections during cancer chemotherapy in children.
Universitätskinderklinik Berlin, Abt. Hämatologie/Onkologie.
P
P
Hadjilaskari
G
G
Roehrig
R
R
Hartmann
R
R
Fengler
G
G
Henze
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007223:Infant; D007938:Leukemia / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D009894:Opportunistic Infections / Q000628:therapy*; D012189:Retrospective Studies
D003520:Cyclophosphamide
Einfluss der 7S-immunoglobulin substitution auf die Häufigkeit und den Verlauf von Infektionen bei zytostatisch behandelten Patienten.