Metabolites of (+)-dehydroabietic acid in rabbits.
The seven metabolites of (+)-dehydroabietic acid (DHA) were newly isolated from rabbit urine by liquid chromatography. On the basis of chemical and spectral data their structures were established to be (15S)-8,11.13-abietatrien-16,18-dioic acid, 2 alpha-hydroxy-8,11,13,15-abietatetraen-18-oic acid, (15R)-15,16-dihydroxy-8,11,13-abietatrien-18-oic acid, 2 beta,15-dihydroxy-8,11,13-abietatrien-18-oic acid, (15S)-2 beta,16-dihydroxy-8,11,13-abietatrien-18-oic acid, 2 alpha,15-dihydroxy-8,11,13-abietatrien-18-oic acid, and (15S)-2 alpha,16-dihydroxy-8,11,13-abietatrien-18-oic acid. The possible hydroxylation routes of DHA in rabbits and the difference between the metabolism of DHA in microorganisms and that in rabbits are discussed.
Department of Chemistry, Faculty of Sciences, Hiroshima University, Japan.
T
T
Matsumoto
N
N
Hayashi
T
T
Ishida
Y
Y
Asakawa
D045784:Abietanes; D000818:Animals; D001711:Biotransformation; D004224:Diterpenes / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D011817:Rabbits
D045784:Abietanes; D004224:Diterpenes; C013913:dehydroabietic acid