[Application of the Weibull function to the study of in vivo/in vitro correlation].
After transformation of concentration-time curves by integration, the Weibull function is calculated, producing an equation for a derived function representing the plasma (or salivary) kinetics. This model can be employed in the analysis of in vivo/in vitro correlations, since cumulated dissolution percentages can be directly expressed as Weibull functions. A method was developed for prediction of salivary kinetics from in vitro dissolution data and the in vivo kinetics of a solution of the drug. This method was applied to results obtained for slow release formulations of acetaminophen and theophylline administered by the oral route.
Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, Toulouse.
F
F
Rodriguez
E
E
Arama
M
M
Magbi
T
T
Paulin
R
R
Rouffiac
D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D012463:Saliva / Q000378:metabolism; D013223:Statistics as Topic
Application de la fonction de Weibull à l'étude des corrélations in vivo/in vitro.