Transplacental induction of membranous nephropathy in a neonate.
We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.
Department of Paediatrics, Sophia Children's Hospital, Erasmus University Medical School, Rotterdam, The Netherlands.
J
J
Nauta
E
E
de Heer
W M
WM
Baldwin
F J
FJ
ten Kate
A J
AJ
v d Heijden
E D
ED
Wolff
D000328:Adult; D001323:Autoantibodies / Q000378:metabolism; D001324:Autoantigens; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007231:Infant, Newborn; D007668:Kidney / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange; D008871:Microvilli / Q000276:immunology / Q000473:pathology; D011247:Pregnancy
D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G