Effects of prenatal exposure to lithium on indoleamines in maturing mouse brain.
Levels of the intermediates 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) and activities of the enzymes 5-hydroxytryptophan decarboxylase (5-HTPD) and monoamine oxidase (MAO) were measured in 4 different brain regions of maturing mice exposed to LiCl during prenatal and postnatal development. 5-HT and 5-HIAA levels were reduced significantly in all brain regions of 1 day old mice. 5-HIAA was also reduced in hemispheres of 1 week olds. There were some marginally significant elevations and reductions in 5-HTPD and MAO activity at various ages. It is suggested that lithium is reducing 5-HT synthesis and perhaps storage also but that neonates recover quite rapidly from the prenatal exposure.
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Hoff
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Baker
D000818:Animals; D000831:Animals, Newborn; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000032:analysis; D001923:Brain Chemistry / Q000187:drug effects*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008094:Lithium / Q000494:pharmacology*; D051379:Mice; D008995:Monoamine Oxidase / Q000032:analysis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D008995:Monoamine Oxidase; D001142:Aromatic-L-Amino-Acid Decarboxylases