Renin-secreting tumors.
Hypertension resulting from a renin-secreting tumor was first reported in 1967 by Robertson et al. Kihara and coworkers subsequently coined the term juxtaglomerular cell tumor for a similar tumor in a young woman with hyperreninemic hypertension. Since the description of these first two cases, it has become clear that renin-secreting tumors of both renal and nonrenal origin can cause surgically curable hypertension. Primary reninism has been suggested as a more appropriate term for the clinical syndrome associated with renin-secreting tumors, both renal and extrarenal, whether benign or malignant.
Veterans Administration Medical Center, Oklahoma City, OK.
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Roswell
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension; D007008:Hypokalemia; D007606:Juxtaglomerular Apparatus; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D009369:Neoplasms / Q000378:metabolism; D012083:Renin / Q000097:blood / Q000378:metabolism*
D012083:Renin