Intranasal vasotocin decreases cerebrospinal fluid 5-HIAA levels in man.
A single dose (10 ng/kg) of the nonapeptide arginine vasotocin (AVT) administered intranasally to healthy young men, significantly decreased 5-HIAA levels in the lumbar cerebrospinal fluid (CSF) 8 hr after its administration. So far, this represents the smallest amount of an active substance able to alter CSF 5-HIAA levels in man. It is suggested that the decrease of CSF 5-HIAA levels after AVT administration reflects an AVT-induced reduction of the brain 5-HT turnover.
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D000281:Administration, Intranasal; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D014668:Vasotocin / Q000008:administration & dosage* / Q000494:pharmacology
D006897:Hydroxyindoleacetic Acid; D014668:Vasotocin