[Effect of lithium oxybutyrate on the serotonin and 5-hydroxyindoleacetic acid content in the brain of rabbits].
Single administration of lithium hydroxybutyrate (10 mg/kg) to rabbits decreased serotonin and 5-hydroxyindoleacetic acid (5-HIAA) content in the caudate nucleus. The drug administration for 8 days is accompanied by mediator accumulation in the cortex, caudate nucleus, tonsils, hypothalamus, thalamus, and midbrain with parallel reduction in 5-HIAA level in these structures. 15 days of lithium hydroxybutyrate administration lead to the increase of serotonin and 5-HIAA concentration, while 28 days of administration reduced the content of mediator and its metabolite.
Saratikov
A S
AS
Fisanova
L L
LL
Zamoshchina
T A
TA
Sakharova
S A
SA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D006885:Hydroxybutyrates / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009942:Organometallic Compounds; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C022826:lithium hydroxybutyrate; D008094:Lithium
Vliianie oksibutirata litiia na soderzhanie serotonina i 5-oksiindoluksusnoĭ kisloty v mozge krolikov.