The regionalization of [3H]dihydrotetrabenazine binding sites in the mouse brain and its relationship to the distribution of monoamines and their metabolites.
[3H]Dihydrotetrabenazine binding was measured in 8 areas of the mouse brain. In all areas, binding occurred on a homogeneous class of sites (Kd approximately equal to 2.6 nM). The density of [3H]dihydrotetrabenazine binding sites strongly varied between the different brain structures; it was compared to endogenous levels of biogenic monoamines and their metabolites: the density is independent of the nature of the monoamine and of neuronal activity, but is highly correlated to the total amount of monoamines present in each structure.
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Scherman
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Boschi
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Rips
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Henry
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D001665:Binding Sites; D001679:Biogenic Amines / Q000032:analysis*; D001921:Brain / Q000378:metabolism*; D006719:Homovanillic Acid / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000032:analysis; D012701:Serotonin / Q000032:analysis; D013572:Synaptic Vesicles / Q000378:metabolism; D013747:Tetrabenazine / Q000031:analogs & derivatives* / Q000378:metabolism
D001679:Biogenic Amines; D009419:Nerve Tissue Proteins; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; C032811:dihydrotetrabenazine; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid; D013747:Tetrabenazine