[Screening of drugs and chemicals by wide-bore capillary gas chromatography. II. Detection of drugs and chemicals in the blood].
This paper describes the detection limit for 23 drugs and chemicals in the blood by means of a screening method that uses a gas chromatographic system equipped with a wide-bore capillary column and a nitrogen phosphorus detector. The detection limit by this method was determined as being 1 mm of peak height at the detector's range of 100 and 8 of attenuation. Using this scale, the absolute detection limit was in the range of 1 pg for malathion and sumithion to 1 ng for meprobamate. The detection limit of drugs and chemicals in the blood was 5 ng/ml for sumithion to 8 micrograms/ml for meprobamate. Therefore, this screening method is able to detect the presence of drugs even a therapeutic-level dosages, with the exception of compounds such as haloperidol, which have extremely low therapeutic dosage levels.
Kageura
M
M
Department of Legal Medicine, Fukuoka University School of Medicine.
Hara
K
K
Hieda
Y
Y
Takamoto
M
M
Morinaga
M
M
Fujiwara
Y
Y
Fukuma
Y
Y
Kashimura
S
S
D001774:Blood Chemical Analysis / Q000379:methods; D002849:Chromatography, Gas / Q000379:methods; D005278:Fenitrothion / Q000097:blood; D006801:Humans; D008294:Malathion / Q000097:blood; D008620:Meprobamate / Q000097:blood; D009584:Nitrogen / Q000097:blood; D010758:Phosphorus / Q000097:blood; D014116:Toxicology
D010758:Phosphorus; D008620:Meprobamate; D009584:Nitrogen; D008294:Malathion; D005278:Fenitrothion