Strategies for the modulation of neuroimmunological disease at the level of autoreactive T-lymphocytes.
Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antigens. Autoreactive helper T cell lines may become useful tools for the evaluation of new immunotherapeutic strategies. (1) Treatment with anti-Ia monoclonal antibodies presumably interferes with the interaction between Ia on the surface of antigen-presenting cells and the autoreactive T cell receptor; (2) Therapy with unmodified or modified autoantigen may be used to tolerize or delete the autoimmune T cells; (3) Monoclonal antibodies against the 'T cell domains' of autoantigen may prevent its recognition by the autoreactive T cells; (4) Treatment with monoclonal antibodies against T cell clonotypic or differentiation antigens may effectively delete or inactivate the autoreactive T cells. Furthermore, autoreactive helper T cells may be used to induce and establish anti-idiotypic suppressor T cell lines, or the autoimmune helper T cells may themselves display suppressive effects in an allogeneic system.
Hohlfeld
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Toyka
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D000818:Animals; D000906:Antibodies / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000628:therapy; D000939:Epitopes / Q000276:immunology; D007167:Immunotherapy; D009115:Muridae; D009157:Myasthenia Gravis / Q000276:immunology / Q000628:therapy; D012377:Rodentia; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D001324:Autoantigens; D000939:Epitopes