Effects of dietary aflatoxin in aflatoxin-resistant and control lines of chickens.
The resistance to a single oral dose (12 mg of aflatoxin per kg of BW) and 4 wk of dietary aflatoxin (2.5 mg per kg of feed) were investigated in chicks selected for five generations for resistance to acute aflatoxicosis (AR) and unselected control (C) chicks. The AR chicks were more resistant to a single oral dose of aflatoxin and had significantly decreased sodium pentobarbital sleeping time compared to C chicks. Four-weeks exposure to dietary aflatoxin did not result in any significant change in BW or feed conversion ratios of chicks from either the C or AR line. However, more sensitive indicators of aflatoxicosis including plasma total protein, albumin, cholesterol concentrations, and gamma glutamyl transferase activity were significantly altered in C chicks but not in AR chicks fed aflatoxin. Percentages of liver lipid and liver hyperplasia score were also significantly altered as a result of dietary aflatoxin treatment in C but not AR chicks. These data indicate that selection-associated differences exist between the C and AR lines of chickens that convey resistance to not only a single oral dose of aflatoxin but also to a more chronic dietary exposure to aflatoxin.
Department of Pharmacology and Toxicology, University of Georgia, Athens 30602.
R O
RO
Manning
R D
RD
Wyatt
H L
HL
Marks
O J
OJ
Fletcher
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001947:Breeding; D002645:Chickens / Q000097:blood / Q000235:genetics* / Q000254:growth & development; D004032:Diet; D005260:Female; D008099:Liver / Q000187:drug effects; D008297:Male; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*
D000348:Aflatoxins