Comparison of the inhibition of biliary excretion produced by certain inducing agents including 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Rats were treated with chlordecone, mirex, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and respective solvent vehicle. Under urethane or pentobarbital anesthesia, the bile duct was cannulated and radioactive morphine, imipramine, or ouabain was given by segmented retrograde intrabiliary injection. The spectrum of inhibition of biliary excretion by chlordecone and mirex were similar in that morphine glucuronide and in part polar imipramine metabolite recoveries in bile were decreased; ouabain recovery was unaffected. TCDD was different in that it markedly decreased the recovery of ouabain. Thus, it appears that chlordecone, mirex, and TCDD inhibit the canalicular transport of the glucuronide metabolites of morphine and imipramine into bile, and TCDD affects in addition the canalicular transport of ouabain into bile.
E F
EF
Berman
P
P
Schaus
J M
JM
Fujimoto
D000818:Animals; D001646:Bile / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D002250:Carbon Radioisotopes; D007631:Chlordecone / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D004347:Drug Interactions; D007099:Imipramine / Q000032:analysis / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D008917:Mirex / Q000494:pharmacology*; D009020:Morphine / Q000032:analysis / Q000378:metabolism; D010042:Ouabain / Q000032:analysis / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium; D014520:Urethane / Q000494:pharmacology
D002250:Carbon Radioisotopes; D004147:Dioxins; D007306:Insecticides; D000072317:Polychlorinated Dibenzodioxins; D014316:Tritium; D014520:Urethane; D010042:Ouabain; D009020:Morphine; D010424:Pentobarbital; D007099:Imipramine; D007631:Chlordecone; D008917:Mirex