[Effect of antidepressants on the balance of biogenic amines and their metabolites in the rat brain].
A study was made of changes in the balance of neuromediator monoamines and metabolistes in rat brain, induced by a single administration of pyrazidol, imipramine and norzimelidine. It was revealed that pyrazidal in a dose of 50 mg/kg increased the level of noradrenaline (NA) and serotonin (5-HT), particularly in the hypothalamus and raphe-nucleus of rat brain. In the same brain regions, imipramine (30 mg/kg) raised the NA content and lowered the concentration of 5-HT and dopamine (DA) metabolites. Norzimelidine (60 mg/kg) elevated the levels of NA and DA in the hypothalamus and reduced the 5-HT content in the raphe nucleus of rat brain. It is suggested that the topography of changes in the balance of biogenic amines in the brain induced by different antidepressants reflects the pharmacological features of their action.
V A
VA
Kamysheva
E M
EM
Gankina
V A
VA
Markin
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002227:Carbazoles / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D011903:Raphe Nuclei / Q000378:metabolism; D051381:Rats; D015031:Zimeldine / Q000031:analogs & derivatives / Q000494:pharmacology
D000928:Antidepressive Agents; D002227:Carbazoles; D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D015031:Zimeldine; D006897:Hydroxyindoleacetic Acid; C017578:norzimelidine; D007099:Imipramine; C009830:pirlindole; D006719:Homovanillic Acid
Vliianie antidepressantov na balans biogennykh aminov i ikh metabolitov v mozge krysy.