Solid and solution behavior of sulphonylurea complexes with ions of IIA group metals. Molecular modeling of K[Zn(ClCH4SO2NCONHC3H7)3] and action of zinc-sulphonylurea complexes as hypoglycemic agents.
Complexes of Zn2+ with deprotonated suphonylurea as ligands have been synthesized and characterized. Deprotonated sulphonylurea act as bidentate ligands using one nitrogen and one oxygen atom (the ureido oxygen) to bind Zn2+ forming K[Zn(suphonylurea)3]. Using the MMX89 program, a model for K[Zn(ClC6H4SO2NCONHC3H7)3] compound is proposed. Conductometric and potentiometric studies in methanol, for d10 metal-sulphonylurea complexes, demonstrated that zinc, cadmium and silver complexes are 1:1 electrolytes and are protonated in the range 4.2-5.6 pH. UV-Vis study shows no interaction between metal and protonated sulphonylureas in methanol solutions. At 7.34 pH the form of Zn complexes which act as a hypoglycemic agent is [ZnL3]-. Test for hypoglycemic activity reduced glycemia to a statistically significant degree compared to the corresponding free ligands.
Hatzidimitriou
A G
AG
Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotelian University of Thessaloniki, Greece.
Kessissoglou
D P
DP
Manoussakis
G E
GE
Kourounakis
P N
PN
Economidis
G
G
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003196:Computer Graphics; D006358:Hot Temperature; D007003:Hypoglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007928:Lethal Dose 50; D008024:Ligands; D008670:Metals / Q000494:pharmacology; D000432:Methanol; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013453:Sulfonylurea Compounds / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D008024:Ligands; D008670:Metals; D009942:Organometallic Compounds; D013453:Sulfonylurea Compounds; D015032:Zinc; D000432:Methanol