Activation of human basophils by bacterial products.
Staphylococcus aureus Cowan I (Cowan Staph A+), which synthesizes protein A (Staph A), induced histamine release from human basophils. In contrast, S. aureus Wood 46 (Wood Staph A-), which does not synthetize Staph A, did not induce histamine secretion. Soluble Staph A and Cowan Staph A+ induced histamine release by interacting with the alternative F(ab')2-binding site of IgE and/or IgG present on human basophils. Pepstatin A, a pentapeptide synthetized by various actinomycetes, induced histamine secretion by activating a specific membrane receptor, which is also activated by synthetic formylmethionine-containing peptides.
Marone
G
G
Columbo
M
M
Tamburini
M
M
Romagnani
S
S
D001491:Basophils / Q000276:immunology*; D006636:Histamine Release; D006801:Humans; D009842:Oligopeptides / Q000276:immunology*; D010436:Pepstatins / Q000276:immunology*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000276:immunology; D013205:Staphylococcal Protein A / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
D009842:Oligopeptides; D010436:Pepstatins; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D013205:Staphylococcal Protein A; C014195:Streptomyces pepsin inhibitor; C031375:pepstatin