In vitro culture of leukemic cells in t(4;11) acute leukemia.
In the present study we utilized a semisolid culture system with feeder cells and enriched media to evaluate the growth of acute leukemia associated with the 4;11 chromosomal translocation. We compared growth of t(4;11) leukemia to typical acute nonlymphocytic leukemia (ANL) and acute lymphocytic leukemia (ALL). The two cases of t(4;11) leukemia tested exhibited the highest cloning efficiency of cells tested. The growth characteristics of t(4;11) leukemia were more similar to ANL than ALL.
Stong
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RC
Kersey
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JH
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D003114:Colony-Forming Units Assay; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008747:Methylcellulose; D009000:Monocytes / Q000648:ultrastructure; D010641:Phenotype; D012008:Recurrence; D013194:Staining and Labeling; D014178:Translocation, Genetic
D008747:Methylcellulose