Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats.
The administration of the 1-methyl-4-phenylpyridinium ion (MPP+) stereotaxically into the left neostriatum or left median forebrain bundle of female rats resulted in a very large and highly significant loss of dopamine and of its metabolites in the left neostriatum. The effect of MPP+ on neostriatal dopamine content was in general considerably greater than its effect on serotonin or on several amino acids. These results are consistent with the premise that MPP+, formed from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by the enzyme monoamine oxidase B, may be responsible for the toxicity observed after MPTP administration.
Heikkila
R E
RE
Nicklas
W J
WJ
Duvoisin
R C
RC
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008474:Medial Forebrain Bundle / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*
D000596:Amino Acids; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine