Effects of corticoadrenal extract on haemorrhagic shock-induced perturbation of systemic haemodynamics and general metabolism in anesthetized dogs.
The effects of intravenous administration of corticoadrenal extract on anesthetized dogs subjected to repeated haemorrhagic shock were studied by measuring 10 variables of respiration, general metabolism and systemic haemodynamics. Haemorrhagic shock induced a slowing down of respiratory rate and a decrease in the ventilatory output, stimulated the general metabolism, depressed cardiac performance and provoked a decrease in the total peripheral resistance and elastic resistance of arteries. In the group of animals treated with corticoadrenal extract (10 U/kg/min), the slowing down of respiratory rate was completely abolished as well as the depression of the total peripheral and elastic resistance of arteries. Meanwhile general metabolism was stimulated. These results suggest that corticoadrenal extract protect anesthetized dogs against the hypotension induced by a sudden fall of blood volume.
Chahine
R
R
Centre de Recherche, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.
Cheav
S L
SL
Nguyen Van Thoai
M
M
D000302:Adrenal Cortex / Q000502:physiology*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology; D014020:Tissue Extracts / Q000627:therapeutic use*
D014020:Tissue Extracts