[NK and K cell activity in children with leukemias and aplastic anemias before and after allogeneic bone marrow transplantation].
Mononuclear leukocytes from the peripheral blood and bone-marrow of children affected with aplastic anemia and leukemia were investigated for K-cell activity (antibody-dependent cellular cytotoxicity) and NK-cell activity before and after allogenous bone-marrow transplantation. 51Cr liberation test against murine Graffi erythroblast leukemic cells covered with xenoantibodies and K-562 cells were used for identification. Strongly lowered NK- and K-cell activities could be found in aplastic anemia prior to bone-marrow transplantation. However, NK-cell activity was only lowered significantly in leukemic patients with indication of bone-marrow transplantation. K-cell and NK-cell activities normalised after bone-marrow transplantation. K-cell and NK-cell activities could be observed to be reconstituted very early after bone-marrow transplantation.
H
H
Thränhardt
J
J
Prager
D
D
Fuchs
F
F
Zintl
W
W
Plenert
D000741:Anemia, Aplastic / Q000276:immunology* / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000276:immunology* / Q000628:therapy
NK- und K-Zell-Aktivität bei Kindern mit Leukämien und aplastischen Anämien vor und nach allogener Knochenmarktransplantation.