Imidazoles and triazoles in antifungal therapy.
Fungal infections range from superficial mycoses involving skin or mucous membranes to severe opportunistic infections that may be fatal. The selection of chemotherapeutic agents useful for the treatment of fungal infections includes many topical or systemic imidazoles and triazoles. This overview compares and contrasts the pharmacology and therapeutic use of these agents. This review will focus primarily on these agents' mechanism of action, pharmacokinetics, clinical studies, and adverse reactions.
Cleary
J D
JD
Department of Clinical Pharmacy Practice, University of Mississippi, Jackson 39216.
Taylor
J W
JW
Chapman
S W
SW
D000818:Animals; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D009181:Mycoses / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*
D007093:Imidazoles; D014230:Triazoles