Five-year outcome of infants of birthweight 500 to 1500 grams: relationship with neonatal ultrasound data.
Of 154 consecutive survivors of birthweight 500 to 1500 gm, 139 (90.3%) were seen at 5 years of age, corrected for prematurity, and 137 (89%) were able to be fully assessed by both the psychologist and pediatrician. All but two children had had serial cranial ultrasonography with a linear array real-time scanner in the neonatal period. At 5 years, of 39 children with cerebral ultrasound abnormalities detected during their primary hospitalization, seven (17.9%) had cerebral palsy, but 32 (82.1%) did not. A further three children with cerebral palsy at 5 years had had no cerebral abnormalities on ultrasound. Of the cerebral abnormalities diagnosed by ultrasound, ventricular dilation, with or without cerebroventricular hemorrhage, had the highest positive predictive value (40%) for cerebral palsy at 5 years. In the 127 children free from cerebral palsy at 5 years, two (1.6%) had severe intellectual impairment, both of whom had had normal cerebral ultrasonography. Although neonatal cranial ultrasonography with a linear array was somewhat predictive of cerebral palsy at 5 years, the majority of infants with abnormal scans had no severe sensorineural impairments at 5 years.
Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia.
W H
WH
Kitchen
G W
GW
Ford
A L
AL
Rickards
L W
LW
Doyle
E
E
Kelly
L J
LJ
Murton
D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis; D002547:Cerebral Palsy / Q000175:diagnosis / Q000209:etiology; D002552:Cerebral Ventricles / Q000473:pathology*; D002648:Child; D004108:Dilatation, Pathologic; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology; D011379:Prognosis; D014463:Ultrasonography