Synthetic peptides in the analysis of the induction and regulation of delayed-type hypersensitivity to lysozyme.
T cells mediating hen egg lysozyme (HEL)-specific delayed hypersensitivity can be activated by synthetic peptides of the 1-18 amino acid residues of hen egg lysozyme. The N-terminal 1-18 peptides of hen egg (PHEL) and ring-necked pheasant lysozyme (PREL) are highly cross-reactive in the induction of T cells mediating delayed hypersensitivity. The N-terminal 1-18 peptides of hen egg and ring-necked pheasant lysozyme (PHEL and PREL) are not cross-reactive in the induction of suppressor T cells, demonstrating that phenylalanine at amino acid residue 3 is critical for the formation of an epitope recognized by T suppressor cells.
Colizzi
V
V
Palmieri
G
G
Sette
A
A
Appella
E
E
Doria
G
G
Adorini
L
L
D000595:Amino Acid Sequence; D000818:Animals; D001717:Birds / Q000276:immunology; D002645:Chickens / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006968:Hypersensitivity, Delayed; D009113:Muramidase / Q000276:immunology*; D010063:Ovum / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000939:Epitopes; D010446:Peptide Fragments; D009113:Muramidase