Antigen specific human T cell clones: heterogeneity of specificity and function.
Human T cell clones specific for either mycobacterial or viral antigens have been generated and characterized. Different antigenic structures were recognized by T cells which had specific functions. These appeared to be directed at a number of target effector cells. Even where a number of T cell clones mediated the same function variation in clonal products suggested this might be achieved by different mechanisms. The multiplicity of immune function displayed by these T cell clones is discussed in the context of their antigenic specificity and genetic restriction.
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Rees
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Knott
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Lamb
D000942:Antigens, Bacterial / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000378:metabolism; D009161:Mycobacterium / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000942:Antigens, Bacterial; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D000956:Antigens, Viral; D000939:Epitopes; D007376:Interleukin-2