A case of squamous cell carcinoma treated by intralesional injection of oil bleomycin.
The case of a 70-year-old man with squamous cell carcinoma on the glabella which markedly responded to intralesional injections of oil bleomycin (to a total dose of 115 mg) is reported. Adverse reactions to oil bleomycin comprised fever of 37-38 degrees C immediately after injection, local redness, and swelling and induration of 1-2 months' duration in the marginal area of the injection site. Biopsy of the induration revealed oleogranuloma. The advantages of oil bleomycin are that this dosage form of bleomycin is not accompanied by severe systemic toxicities such as pulmonary fibrosis and that the effective dose is smaller than that of aqueous bleomycin.
Tanigaki
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T
Endo
H
H
D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage* / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005546:Forehead; D006801:Humans; D007267:Injections; D008297:Male; D009821:Oils; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
D009821:Oils; D001761:Bleomycin