Indomethacin enhances in vitro histamine release induced by anti-IgE and Ca-ionophore but inhibits C5a-induced release reactions from basophils of atopics and normals.
Preincubation of peripheral leukocytes from atopics and normals significantly enhanced histamine release induced by anti-IgE and calcium ionophore. On the other hand, there was a significant inhibition (ca. 40%) of C5a-induced histamine release by indomethacin both in atopics and controls. In the group of patients with atopic eczema, anti-IgE-induced histamine release was significantly higher than in controls both without and with indomethacin.
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D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001491:Basophils / Q000187:drug effects / Q000276:immunology*; D000001:Calcimycin / Q000494:pharmacology; D003182:Complement C5 / Q000276:immunology; D015936:Complement C5a; D015232:Dinoprostone; D004485:Eczema / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007213:Indomethacin / Q000494:pharmacology*; D008875:Middle Aged; D011458:Prostaglandins E / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D003182:Complement C5; D011458:Prostaglandins E; D007073:Immunoglobulin E; D000001:Calcimycin; D015936:Complement C5a; D015232:Dinoprostone; D007213:Indomethacin