Some hemopoietic negative regulators.
Hemopoietic negative regulators are growth inhibitory proteins or peptides of natural origin that exert their effects on cells of the blood-forming system. They are biologically defined by quantitative assay methods that exclude toxicity as a basis for their action. They act within minutes to hours, in a readily reversible and more-or-less specific manner on stem cells and progenitor cells, during S-phase to arrest DNA synthesis, or during G1 to prevent entry into DNA synthesis. Operating at picomolar to nanomolar concentrations through high-affinity receptors at their target cell surface, they oppose the action of stimulatory (or positive regulatory) growth factors. Hemopoietic negative and positive regulators acting in concert thus appear to provide a mechanism for rapid, reversible, and specific proliferative responses to changes in hemopoietic demand.
Department of Anatomy, University of Toronto, Canada.
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D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D006131:Growth Inhibitors / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans
D006131:Growth Inhibitors; D004247:DNA