Reactivity with neural cell adhesion molecules in sera from patients with demyelinating diseases.
Sera from 5 patients with IgM gammopathy and peripheral neuropathy reacted strongly by a sensitive immunospot enzyme-linked immunosorbent assay test with the myelin-associated glycoprotein (MAG) purified from human and bovine brains and the novel neural cell adhesion molecule J1 and associated glycoproteins from human brain. Two other members of the L2/HNK-1 family of cell adhesion molecules, the L1 glycoprotein and the neural cell adhesion molecule N-CAM, are not recognized significantly more strongly by these sera than by sera from patients with multiple sclerosis. Sera from patients with Guillain-Barré syndrome and amyotrophic lateral sclerosis and from healthy humans did not react with any of the glycoproteins tested at the serum concentrations used.
Poltorak
M
M
Steck
A J
AJ
Schachner
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000097:blood*; D002417:Cattle; D015815:Cell Adhesion Molecules; D003711:Demyelinating Diseases / Q000097:blood* / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M; D051379:Mice; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein