Cell instability in basophil leukocytes of patients with chronic obstructive airway disease.
The histamine release from basophils induced by hypo-osmolarity was investigated in 75 healthy persons and in 43 patients with chronic obstructive airway disease. Leukocyte suspensions were diluted with destilled water in cell/water ratio volumen of 1:1, 1:3, and 1:7. Basophils, sequentially treated with increasing amounts of water, show an activation of the release process. A statistically significant age-dependent hypo-osmolar histamine liberation could be demonstrated. Furthermore, a significant higher cell stability was found for the group of patients.
P
P
Heering
I
I
Zimmermann
A A
AA
Bugalho de Almeida
W T
WT
Ulmer
D000328:Adult; D000367:Age Factors; D001491:Basophils / Q000166:cytology* / Q000276:immunology; D001991:Bronchitis / Q000276:immunology; D005260:Female; D006636:Histamine Release; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values