[Interferon-inducing activity of a tilorone hydrochloride preparation].
The experiments on CBA mice showed that tyloron hydrochloride was an active inductor of interferon. The maximum production of interferon in blood (2560 units/ml) was achieved with oral administration of tyloron in a dose of 400 mg/kg. It was demonstrated that the character of interferon accumulation in different organs depended on the route of tyloron administration. When the inductor was administered orally, the highest levels of interferon were observed in the intestine (5000 units/g) and blood (320-640 units/ml). When the inductor was injected intraperitoneally, significant levels of interferon were detected in the animal brain (at least 5000 units/g). After intramuscular injection of the inductor insignificant levels of interferon were practically detected in all the organs. Participation of the brain cells and blood elements in production of interferon is discussed.
E B
EB
Tazulakhova
N N
NN
Amitina
F I
FI
Ershov
D000818:Animals; D005449:Fluorenes / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013994:Tilorone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D005449:Fluorenes; D007372:Interferons; D013994:Tilorone
Interferonindutsiruiushchaia aktivnost' preparata tilorona gidrokhlorida.