Cooling-induced augmentation of the contractile response of the golden hamster tracheal muscle to substance P in-vitro.
The effect of temperature on the substance P-induced contraction of the isolated tracheal strip-chain preparation from the golden hamster has been examined. A decrease of bath temperature from 37 to 20 degrees C augmented the contractile response of the trachea caused by substance P. Similar cooling-induced augmentation was observed in the contractile responses to caffeine and carbachol, but not to potassium chloride. The increased responsiveness with lowered temperature of the trachea to substance P may be due to the acceleration of Ca2+ release from an intracellular storage site.
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D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D003080:Cold Temperature; D006224:Cricetinae; D066298:In Vitro Techniques; D008297:Male; D008647:Mesocricetus; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D013373:Substance P; D002110:Caffeine; D011189:Potassium Chloride; D002217:Carbachol; D014700:Verapamil; D002118:Calcium