Effects of acute physical exercise on aryl hydrocarbon hydroxylase activity in human peripheral lymphocytes.
It has been reported that physical exercise may enhance cytochrome P-450 dependent drug metabolism in vivo. In this study we report that the specific activity of aryl hydrocarbon hydroxylase (AHH) in human peripheral lymphocytes (HPL) is enhanced approximately two fold following acute physical exercise. This enhancement of AHH activity in HPL appears to be strongly correlated with enhanced lymphocyte count as well as induced metabolic and exercise stress but not with the intrinsic physical fitness of individuals.
Dept of Pharmacology, National University of Singapore, Kent Ridge Crescent.
S M
SM
Moochhala
K P
KP
Fung
R
R
Yuen
N P
NP
Das
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D011659:Pulmonary Gas Exchange
D001189:Aryl Hydrocarbon Hydroxylases