Gamma glutamyl transpeptidase activity in rat urothelium treated with bladder carcinogens.
Gamma glutamyl transpeptidase (GGT) activity during urothelial carcinogenesis was examined histochemically in rats treated with N-methyl-N-nitrosourea (MNU) or N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN). GGT-positive cells developed with a high frequency in foci of nodulopapillary hyperplasia and carcinoma. GGT-positive cells, both individually and in nests, were also frequent in foci of simple hyperplasia and interlesion normal urothelium of carcinogen-treated bladders. The results suggest that development of GGT-positive cells in interlesion normal urothelium is specific to carcinogen treatment.
S
S
Ozono
Y
Y
Homma
R
R
Oyasu
D000818:Animals; D000831:Animals, Newborn; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D006651:Histocytochemistry; D006965:Hyperplasia / Q000201:enzymology; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D009092:Mucous Membrane / Q000201:enzymology; D051381:Rats; D013194:Staining and Labeling; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D002273:Carcinogens; D002085:Butylhydroxybutylnitrosamine; D008770:Methylnitrosourea; D005723:gamma-Glutamyltransferase