Antigen mimicry involving measles virus hemagglutinin and human respiratory syncytial virus nucleoprotein.
Intergenic antigenic relationships between measles virus and respiratory syncytial (RS) virus-specific structural components were studied by using monoclonal antibodies. Of 75 monoclonal antibodies against these components, only one, an anti-measles virus hemagglutinin monoclonal antibody, cross-reacted. Immunofluorescence analysis of measles virus- and RS virus-infected cells with this monoclonal antibody showed qualitatively different staining patterns which indicated that the antigen involved in cross-reaction was the RS virus nucleoprotein or phosphoprotein. A radioimmunoprecipitation assay showed the antigen to be the nucleoprotein.
Norrby
E
E
Sheshberadaran
H
H
Rafner
B
B
D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006389:Hemagglutinins, Viral / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D009698:Nucleoproteins; D014764:Viral Proteins