Calcium regulates the activity of serotonin-containing dorsal raphe neurons in vitro.
Small elevations of calcium ions (15%) significantly depressed the activity of serotonin-containing dorsal raphe neurons by 35% in mouse brain slices in vitro, while large increases in calcium ion concentration (300%) dramatically decreased the incidence of spontaneously active raphe neurons. Neurochemical studies indicated that these effects were not attributable to increased release and metabolism of serotonin. These findings may have implications for the treatment of mood disorders, for which disturbances in both calcium and serotonin metabolism have been demonstrated.
M E
ME
Trulson
T
T
Crisp
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000494:pharmacology / Q000502:physiology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011903:Raphe Nuclei / Q000032:analysis / Q000502:physiology*; D012701:Serotonin / Q000032:analysis / Q000502:physiology*; D009435:Synaptic Transmission; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014365:Tryptophan Hydroxylase; D002118:Calcium