A prospective comparative study on serum acid phosphatases in the diagnostics of prostatic cancer.
The diagnostic efficacy of two prostatic tumor markers, S-AP and S-PAP, was compared in a prospective clinical series consisting of 101 BPH- and 39 PCa-patients. As a predictor of prostatic cancer the specificity of S-AP (greater than or equal to 12 U/1) and S-PAP-RIA (greater than or equal to 4 micrograms/1) was 0.97 and 0.96, and the sensitivity 0.21 and 0.41, respectively. The S-PAP-RIA value of over 8 micrograms/1 always predicted an inoperable prostatic cancer (T4 or M1). The authors conclude that neither of these enzymes is suitable for the screening of early prostatic cancer, but the S-PAP-RIA might be a good predictor of inoperability of advanced prostatic cancer.
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Seppänen
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E
Setälä
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T
Tunturi
D000135:Acid Phosphatase / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000368:Aged; D004796:Clinical Enzyme Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000201:enzymology; D011470:Prostatic Hyperplasia / Q000175:diagnosis*; D011471:Prostatic Neoplasms / Q000145:classification / Q000175:diagnosis*; D011863:Radioimmunoassay
D000135:Acid Phosphatase