Sensitivity of the resting sodium conductivity of leech Retzius nerve cells to tetrodotoxin.
Simultaneously, the effect of sodium-free medium and tetrodotoxin (3 X 10(-8) M/ml) were investigated on some passive electrophysiological properties of leech Retzius nerve cells. Complete replacement of Na+ with Tris or addition of tetrodotoxin to the leech Ringer was followed by an increase of input resistance in contrast to the cell-to-cell interaction which was not affected by such a procedure. At the same time tetrodotoxin was not able to block repetitive spike activity. The data imply the existence of two types of Na+ channel in leech Retzius nerve cells.
Beleslin
B B
BB
D000818:Animals; D004553:Electric Conductivity / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000378:metabolism; D007700:Kinetics; D007865:Leeches / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology*
D007473:Ion Channels; D013779:Tetrodotoxin; D012964:Sodium