Dopaminergic activity of four analogs of butaclamol.
The displacing potency of four analogs of the neuroleptic drug butaclamol were evaluated using dog striatal tissue and [3H]-Spiroperidol as ligand. Although significantly less powerful than the parent compound, two of them (N-isobutyl butaclamol equatorial; N-methyl butaclamol equatorial) could be used for dopaminergic receptor studies.
Collu
R
R
Bouvier
C
C
Basak
A
A
Dugas
H
H
D000818:Animals; D001667:Binding, Competitive; D002069:Butaclamol / Q000031:analogs & derivatives* / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D003986:Dibenzocycloheptenes / Q000378:metabolism*; D004285:Dogs; D008297:Male; D011869:Radioligand Assay; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D003986:Dibenzocycloheptenes; D011954:Receptors, Dopamine; D013134:Spiperone; D002069:Butaclamol