[The characteristics of the sex-differentiating action of sex steroids on the androgen receptors of the rat liver].
A study was made of the specificities of polydifferentiating action of androgens (A) and estrogens (E) on the level of androgen receptors (AR) of the rat liver cytosol. Androgen receptors were shown to be detected in the neonatal period of ontogenesis, their level was progressively on the increase with the body development. Sex differences in their content were revealed in mature animals only. The AR level is a reversibly controlled, but unprogrammed sex-related sign. The effects of sex steroids are dose-related and modulated reciprocally by the action of endogenous A and E. The action of physiological doses of A and E is characterized by slow development of the effect. Correlation between the level of AR and the efficacy of A action on the content of these proteins was revealed.
Oleĭnik
N V
NV
Smirnova
O V
OV
Rozen
V B
VB
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D003600:Cytosol / Q000032:analysis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006128:Growth / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D011869:Radioligand Assay; D051381:Rats; D011944:Receptors, Androgen / Q000032:analysis / Q000187:drug effects*; D012727:Sex Characteristics
D000728:Androgens; D004967:Estrogens; D011944:Receptors, Androgen
Osobennosti poldifferentsiruiushchego deĭstviia polovykh steroidov na retseptory androgenov pecheni krys.