Atomic model of the actin filament.
The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. A unique orientation of the monomer with respect to the actin helix has been found. The main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand. There are also contacts along the left-handed genetic helix.
Holmes
K C
KC
Max-Planck-Institut für Medizinische Forschung, Abteilung Biophysik, Heidelberg, FRG.
Popp
D
D
Gebhard
W
W
Kabsch
W
W
D000199:Actins; D000244:Adenosine Diphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D003850:Deoxyribonuclease I / Q000378:metabolism; D046911:Macromolecular Substances; D008958:Models, Molecular; D015394:Molecular Structure; D010590:Phalloidine; D011487:Protein Conformation; D014961:X-Ray Diffraction
D000199:Actins; D046911:Macromolecular Substances; D010590:Phalloidine; D000244:Adenosine Diphosphate; D003850:Deoxyribonuclease I; D002118:Calcium