Genes on different chromosomes influence the antibody response to bacterial antigens.
B6.C congenic strains of mice, possessing histocompatibility (H) alleles from high responding BALB/cBy (C) mice on the genetic background of low responding C57BL/6By (B6) mice, were assayed for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha(1----3) epitope of bacterial (Leuconostoc) dextran B-1355. The results affirmed that the antibody response to SSS-III is multigenic and that genes making a positive contribution to responsiveness are located on different chromosomes, i.e., chromosomes 1, 3, 4, 5, and 9. At least one other gene also influences responsiveness to SSS-III; it is linked to the H-17 locus, which has not yet been assigned to a specific chromosome. Genes on chromosomes 1, 4, and 5 influence the magnitude of the antibody response to dextran B-1355. Some of these genes may be antigen-specific in their mode of action; however, others may not since they appear to exert a positive influence on the antibody response to both SSS-III and dextran B-1355.
Baker
P J
PJ
Bailey
D W
DW
Fauntleroy
M B
MB
Stashak
P W
PW
Caldes
G
G
Prescott
B
B
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial / Q000276:immunology*; D002874:Chromosome Mapping; D003911:Dextrans / Q000276:immunology; D000939:Epitopes; D005802:Genes, MHC Class II; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D003911:Dextrans; D000939:Epitopes; D011135:Polysaccharides, Bacterial