Age-dependent increase in [3H]verapamil binding to rat cortical membranes.
[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity unchanged. These observations further indicate that aging may affect calcium channels leading to a derangement of calcium movements which in turn alter neuronal activity.
Battaini
F
F
Govoni
S
S
Rius
R A
RA
Trabucchi
M
M
D000367:Age Factors; D000375:Aging; D000818:Animals; D001667:Binding, Competitive; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D009543:Nifedipine / Q000031:analogs & derivatives / Q000378:metabolism; D009568:Nitrendipine; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000378:metabolism*
D007473:Ion Channels; D009568:Nitrendipine; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium