Chromosome abnormalities in pupils attending ESN/M schools.
One hundred and sixty six children attending educationally subnormal/mild (ESN/M) schools were karyotyped as part of a project investigating the aetiology of mild mental retardation. Nine had significant chromosome abnormalities. Five of six children identified during the survey had no dysmorphic features--47,XXY (two), 48,XXYY, 46,XX 15q-, and 46,XX,t(X;19). One dysmorphic boy had a balanced translocation--46,XY,t(3;15). Three were already known--47,XX+21 (two) and 46,XY, 14q+. We suggest that routine karyotyping of children with mild mental retardation be considered.
Lamont
M A
MA
Dennis
N R
NR
Seabright
M
M
D002648:Child; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002658:Developmental Disabilities / Q000235:genetics; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology / Q000235:genetics*; D007621:Karyotyping; D008297:Male