Trypsin/creatinine clearance ratio and serum immunoreactive trypsin in digestive and pancreatic diseases.
The behavior of trypsin/creatinine clearance ratio (Ctr/Ccr) and serum immunoreactive trypsin (IRT) was evaluated in a total of 168 subjects with pancreatic cancer, chronic pancreatitis and non-pancreatic digestive diseases. Amylase/creatinine clearance ratio (Cam/Ccr) and serum amylase levels were also evaluated in order to establish their possible relationship with Ctr/Ccr and IRT values. Elevated Ctr/Ccr and IRT values were observed in several patients with pancreatic cancer and chronic pancreatitis. Abnormal IRT and Ctr/Ccr values were found in 28.2 and 4% of non-pancreatic digestive diseases, respectively. IRT and amylase serum levels showed consensual modifications, while Ctr/Ccr showed a behavior different from that of Cam/Ccr. Liver damage seems to play a role in increasing serum IRT levels of patients without pancreatic involvement, while the increased Ctr/Ccr seems to depend on other factors, for instance renal tubular dysfunction.
G
G
Del Favero
C
C
Fabris
P
P
Bonvicini
A
A
Piccoli
U
U
Baccaglini
S
S
Pedrazzoli
A
A
Burlina
R
R
Naccarato
D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood*; D004066:Digestive System Diseases / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000201:enzymology; D010195:Pancreatitis / Q000097:blood* / Q000201:enzymology; D012008:Recurrence; D014357:Trypsin / Q000097:blood*
D003404:Creatinine; D000681:Amylases; D014357:Trypsin