[Comparative study of the properties of dicoumarin and its compounds with heparin].
After a single administration (intramuscular or per os) of a complex dicoumarin-heparin into rats its hypocoagulation effect exceeded both in the rate and duration the effect of an equimolar doses of dicoumarin. After an intramuscular administration into rats the complex exhibited the hypocoagulation effect within 55 hrs, dicoumarin--within 31 hr. The hypocoagulation effect of the heparin-dicoumarin complex was maintained within 36 hrs, and the effect of dicumarol--within 14 hrs after administration per os.
Kudriashov
B A
BA
Liapina
L A
LA
Zvereva
E G
EG
D000284:Administration, Oral; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001728:Dicumarol / Q000494:pharmacology*; D004338:Drug Combinations; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008297:Male; D051381:Rats; D013997:Time Factors
D004338:Drug Combinations; D001728:Dicumarol; D006493:Heparin
Sravnitel'noe izuchenie svoĭstv dikumarina i ego soedineniĭ s geparinom.