[The induction of cancer of the large intestine in Macaca fascicularis monkeys with 1,2-dimethylhydrazine].
Continuous subcutaneous administration of 16 mg/kg body weight 1,2-dimethylhydrazine three times a month (total dose--1080-3696 mg) to Macaca fascicularis monkeys induced cancer invariably confined to the colon within 34-47 weeks. Biologic, clinical, histologic features and natural course of the tumor proved similar to those of its human counterpart.
D Sh
DSh
Beniashvili
V S
VS
Turusov
L K
LK
Sharashidze
V A
VA
Krutovskikh
N G
NG
Turkiia
M S
MS
Sartaniia
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004127:Dimethylhydrazines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007279:Injections, Subcutaneous; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007420:Intestine, Large / Q000473:pathology; D008207:Lymphatic Metastasis; D008252:Macaca fascicularis; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D013997:Time Factors
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine
Induktsiia raka tolstoĭ kishki u obez'ian Macaca fascicularis 1,2-dimetilgidrazinom.