[Potential cardiotonic agents. 8. 2-acyloxyalkylamino-, 2-acyloxyalkoxy-, and 2-acylaminoalkylamino-3-cyan-5-(pyrid-4-yl) pyridine].
By acylation of our previously described cardiotonic active 2-hydroxyalkylamino, 2-hydroxyalkoxy, 2-aminoalkyl-amino and 2-piperazino substituted 3-cyano-5-(4-pyridinyl) pyridines with acetic anhydride, propionic anhydride or aroyl and heteroaroyl chlorides, respectively, the corresponding in position 2 O- or N-acylated 3-cyano-5-(4-pyridinyl)pyridines were prepared. Cardiovascular activity of the obtained derivatives is discussed in comparison with that of the parent compounds.
Akademie der Wissenschaften der DDR.
V
V
Hagen
E
E
Klauschenz
A
A
Rumler
H
H
Niedrich
A
A
Hagen
S
S
Heer
R
R
Mitzner
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000676:Amrinone / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000588:Amines; D002316:Cardiotonic Agents; D009570:Nitriles; D011725:Pyridines; D000676:Amrinone
Potentielle Kardiotonika. 8. Mitteilung: 2-Acyloxyalkylamino-, 2-Acyloxyalkoxy- und 2-Acylaminoalkylamino-3-cyan-5-(pyrid-4-yl) pyridine.