Effects of changes in serum calcium and parathyroid hormone on plasma renin in intact mongrel dogs.
Studies were undertaken to extend previous experiments of the interaction between calcium and parathyroid hormone on renin synthesis by the kidney. Intact normovolemic mongrel dogs between 15 and 25 kg were used for all studies. Plasma renin activity (PRA) was measured by radioimmunoassay. Hypocalcemia produced by thyroparathyroidectomy or chelation with EDTA resulted in an elevated PRA of 3.76 +/- 0.85 ng/ml/h in 17 normotensive dogs compared to 1.52 +/- 0.29 ng/ml/h in 14 normocalcemic normotensive dogs (p less than 0.05). In 5 renovascular dogs, calcium-channel antagonism with nifedipine resulted in a higher PRA of 31.8 +/- 0.5 compared to 11.9 +/- 1.1 ng/ml/h in 23 control renovascular dogs not receiving nifedipine (p less than 0.001). The reactive hyperreninemia following angiotensin blockade was greater in 22 hypocalcemic (10.94 +/- 2.03 ng/ml/h) normotensive dogs compared to 14 normocalcemic normotensive dogs (1.32 +/- 0.34 ng/ml/h, p less than 0.001). Similar results were obtained with angiotensin blockade in nifedipine-treated animals compared to angiotensin blockade in nonnifedipine-treated normotensive dogs. Results with angiotensin blockade on PRA levels in renovascular dogs were found similar to those described with angiotensin blockade in normotensive dogs. We conclude from these studies that calcium reduction, independent of a rise in parathyroid hormone, or calcium-channel blockade was associated with an elevation of PRA in normotensive and renovascular hypertensive dogs.(ABSTRACT TRUNCATED AT 250 WORDS)
Zawada
E T
ET
Johnson
M
M
D000818:Animals; D002118:Calcium / Q000097:blood*; D004285:Dogs; D004492:Edetic Acid / Q000494:pharmacology; D006978:Hypertension, Renovascular / Q000097:blood*; D006996:Hypocalcemia / Q000209:etiology; D007473:Ion Channels / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D010280:Parathyroid Glands / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood*; D012083:Renin / Q000096:biosynthesis / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D013965:Thyroidectomy
D007473:Ion Channels; D010281:Parathyroid Hormone; D004492:Edetic Acid; D012083:Renin; D009543:Nifedipine; D002118:Calcium