Sperm chromosome analysis in a man heterozygous for a reciprocal translocation 46,XY t(12;20)(q24.3;q11).
Sperm chromosome complements were studied in a man who carried a reciprocal translocation t(12;20)(q24.3;q11). A total of 113 spermatozoa were karyotyped after in-vitro penetration of hamster eggs. 2:2 and 3:1 meiotic segregations were observed with the following frequencies: alternate 47%, adjacent 1 42%, adjacent 2 10%, 3:1 2%. For alternate segregations, the number of normal spermatozoa (25) was not significantly different from the number of spermatozoa carrying a balanced form of the translocation (28), as theoretically expected. The proportion of spermatozoa with an unbalanced form of the translocation was 53%. There was no evidence for an interchromosomal effect since the frequencies of numerical and structural abnormalities (unrelated to the translocation) were within the normal range of control donors.
Martin
R H
RH
Department of Paediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
McGillivray
B
B
Barclay
L
L
Hildebrand
K
K
Ko
E
E
D000328:Adult; D002881:Chromosomes, Human, Pair 12; D002890:Chromosomes, Human, Pair 20; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D010375:Pedigree; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic