[Transplacental carcinogenic effect of the serotonin derivative 5-methoxyindoleacetic acid].
Transplacental administration of serotonin metabolite 5-methoxyindole-3-acetic acid possessing blastomogenic activity induced the development of malignant and benign neoplasms (lymphosarcomas, adenomas, hepatomas and other tumours) in 84% of C57BL/6 mouse progeny. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were more malignant.
Malakhova
N V
NV
Raushenbakh
M O
MO
D000818:Animals; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
C001736:5-methoxyindoleacetic acid; D006897:Hydroxyindoleacetic Acid
Transplatsentarnoe kantserogennoe vozdeĭstvie proizvodnogo serotonina 5-metoksiindolil-3-uksusnoĭ kisloty.