Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.
It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.
Larsen
C P
CP
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, United Kingdom.
Morris
P J
PJ
Austyn
J M
JM
D000818:Animals; D000911:Antibodies, Monoclonal; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000502:physiology*; D001810:Blood Volume; D002465:Cell Movement; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D016027:Heart Transplantation / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology*; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal