Dermal vascular IgA deposits in IgA nephropathy secondary to alcohol abuse.
Skin, kidney and liver samples were investigated from 103 people with evidence of alcohol abuse at forensic autopsy. The diagnosis of alcohol abuse was based on clinical history, post mortem blood alcohol level and liver pathology. The findings confirmed the frequent widespread vascular IgA deposition in individuals with evidence of alcohol abuse. The frequency of IgA deposition in superficial small vessels of the dermis was not significantly different between individuals with IgA nephritis (16/85) and without such pathology (7/38). Based on these results, it can be inferred that had a pre-mortem skin biopsy been performed, it would not have had clinical usefulness in predicting the renal disease.
Department of Pathology, School of Medicine, University of New Mexico, Albuquerque 87131.
S M
SM
Smith
W E
WE
Hoy
D000437:Alcoholism / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D001344:Autopsy; D005922:Glomerulonephritis, IGA / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007198:Indians, North American; D007223:Infant; D007668:Kidney / Q000032:analysis / Q000473:pathology; D008099:Liver / Q000032:analysis / Q000473:pathology; D011446:Prospective Studies; D012867:Skin / Q000032:analysis* / Q000276:immunology / Q000473:pathology; D044465:White People
D007070:Immunoglobulin A