Woodfordin C, a macro-ring hydrolyzable tannin dimer with antitumor activity, and accompanying dimers from Woodfordia fruticosa flowers.
Three new dimeric hydrolyzable tannins, woodfordins A, B and C, along with seven known hydrolyzable tannins, including oenothein B, a dimer exhibiting marked host-mediated antitumor activity, were isolated from an Indonesian crude drug, Sidowayah [dried flowers of Woodfordia fruticosa (L.) Kurz (Lythraceae)]. The structures of the new tannins were elucidated based on chemical and spectral evidence. Woodfordin C, having a macro-ring structure, was also found to exhibit a significant antitumor activity.
Yoshida
T
T
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Chou
T
T
Nitta
A
A
Miyamoto
K
K
Koshiura
R
R
Okuda
T
T
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D047348:Hydrolyzable Tannins; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000032:analysis*; D013634:Tannins / Q000032:analysis / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D047348:Hydrolyzable Tannins; D013634:Tannins; C065469:woodfordin C