[Extended storage preservation of swine kidneys to 72 hours using iloprost].
The intraaortal infusion of Iloprost (1 micrograms/kg X min) for the duration of 15 minutes leads to an increase of the renal hematorrhea by 85.2%, to a decrease of the renal resistance by 51.6% and to a slight decrease of the average arterial blood pressure by 13.3%. After a 72-hour hypothermic storage preservation under addition of Iloprost the renal blood supply after retransplantation corresponded to the initial values of the blood flow before nephrectomy. The production of urine began after 1-2 minutes. Enzyme investigations of the transplant urine resulted in an increased excretion of the cytosolic enzymes, the structure-bound enzymes, however, remained in the area of the norm. The investigation of the electrolytes of the urine showed a hypersodiuria as well as a hypopotassiuria and calciuria. As to urea and creatinine the values were below the parameters used for comparison. In the contralateral kidneys used as control kidneys no blood supply developed after retransplantation. The application of Iloprost for the conditioning of donor kidneys is very well suited and shows some advantages compared with the preparation used up to now. The prolongation of the hypothermic storage preservation to 72 hours seems to be possible by the application of Iloprost.
U
U
Rebmann
B
B
Langkopf
I
I
Schabel
H D
HD
Pauer
H
H
Heynemann
W
W
Förster
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology*; D016285:Iloprost; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D012079:Renal Circulation / Q000187:drug effects; D013552:Swine; D013997:Time Factors
D002317:Cardiovascular Agents; D011464:Epoprostenol; D016285:Iloprost
Die Verlängerung der Lagerungskonservierung von Schweinenieren auf 72 Stunden durch Einsatz von Iloprost.