D-aspartic acid in purified myelin and myelin basic protein.
The presence of the biologically uncommon D-isomer of aspartic acid in the white matter of human brains has been reported previously from this laboratory (1). We now report that the level of D-aspartate in human brains is higher in purified myelin than in white matter and is even higher in the myelin basic protein fraction. There also appears to be a difference in the level of D-aspartate found in human brain as compared to bovine brain, possibly a species or age-related difference.
G H
GH
Fisher
N M
NM
Garcia
I L
IL
Payan
R
R
Cadilla-Perezrios
W A
WA
Sheremata
E H
EH
Man
D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis*; D001923:Brain Chemistry; D002417:Cattle; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism; D004676:Myelin Basic Protein / Q000032:analysis*; D009186:Myelin Sheath / Q000032:analysis*; D013237:Stereoisomerism
D004676:Myelin Basic Protein; D001224:Aspartic Acid