Metabolism of the malignant astrocytoma.
A comprehensive review of the biochemical organization of the malignant astrocytoma is presented. The review is intended for neurosurgeons. It outlines the metabolic flow of events beginning with energy and substrate utilization, followed by structural components (protein, lipids, etc.) and tumor cell secretory products, and ending with nucleic acid synthesis. Cellular pH, tumor-induced cerebral edema, tumor blood flow, and tumor necrosis are also considered.
Department of Neurosurgery, New York Medical College, Valhalla.
J R
JR
Mangiardi
P
P
Yodice
D001254:Astrocytoma / Q000201:enzymology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism; D006019:Glycolysis; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D011073:Polyamines / Q000378:metabolism; D014176:Protein Biosynthesis; D011743:Pyrimidines / Q000378:metabolism
D006133:Growth Substances; D011073:Polyamines; D011743:Pyrimidines