[Cathepsin D: an independent prognostic factor in cancer of the breast].
The total amount of cathepsin-D (mature forms and pro-enzyme especially) in the cytosol of 88 breast cancers including 85 primary cancers and 11 axillary lymph node metastasis was measured by way of immuno-radiometric assay. Maximum follow-up is 58 months. Cathepsin-D was found to be independent of clinical and biological parameters including axillary lymph node involvement and oestradiol receptors (RE). Univariate analysis has pointed out a significant linkage between overall survival and cathepsin-D, using a cut-off level of 30 pmol/mg protein which is the most discriminating value. Cathepsin-D appeared to be particularly useful in lymph-node-positive and RE-negative patients but it was not significant in the node-negative population. Multivariate analysis of the overall survival (Cox model) revealed that it was strongly related to oestradiol receptor, lymph node involvement and cathepsin-D.
Laboratoire d'oncologie biologique-biopathologie tissulaire, faculté de médecine de Marseille-secteur nord, France.
S
S
Romain
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X
Muracciole
I
I
Varette
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C
Bressac
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H
Brandone
P M
PM
Martin
D000328:Adult; D001365:Axilla; D001943:Breast Neoplasms / Q000032:analysis* / Q000453:epidemiology / Q000473:pathology; D002402:Cathepsin D / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D002402:Cathepsin D
La cathepsine-D: un facteur pronostique indépendant dans le cancer du sein.