The absence of influence of acetylsalicylic acid (ASA) on the transient decrease in platelet counts observed after infusion of bleomycin and vinblastine.
Retrospectively we observed an early-onset transient decrease in platelet counts in a group of patients treated with cisplatin, vinblastine and bleomycin. Though less pronounced, the decrease was also found in a prospectively studied group of patients treated with bleomycin, etoposide and cisplatin, but was absent after treatment with etoposide ad cisplatin. In a randomized cross-over study acetylsalicylic acid (ASA) appeared not to prevent the drop in platelet counts. Bleomycin appears to induce an early-onset transient decrease in platelet numbers, possibly by direct or indirect platelet lysis. Vinblastine may have a synergistic effect to this phenomenon.
Verweij
J
J
Kester
D M
DM
Breed
W P
WP
Hillen
H F
HF
Pinedo
H M
HM
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001761:Bleomycin / Q000009:adverse effects*; D004357:Drug Synergism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D011446:Prospective Studies; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000139:chemically induced*; D014747:Vinblastine / Q000009:adverse effects*
D001761:Bleomycin; D014747:Vinblastine; D001241:Aspirin