[Vasodilating effects of etimizol in vitro and its relation to purinergic receptors].
The paper is concerned with the effect of the breath analeptic agent etimizole on the smooth muscle of vessels under in vitro conditions from the viewpoint of its assumed interaction with purinergic receptors. Isolated preparations of the coronary artery and a. dorsalis pedis of the dog served as experimental material. Etimizole administered in a cumulative manner in dependence on concentration decreases the strength of contraction of the preparations contracted with K+ ions. This relaxant effect, similarly as the effect of adenosine, is not affected by a removal of the endothelium, can be inhibited with theophylline and potentiated with dipyridamole. Etimizole in higher concentrations inhibits the response of vascular preparations to electrical stimulation. In the concentration of 10(-4) mol.l-1 it potentiates the relaxant effect of adenosine, the experimental effects not differing from the theoretical curve for the addition of effects. The obtained results support the assumption that the vasodilating effect of etimizole is mediated prevalently by P1 purinergic receptors.
Sotníková
R
R
Ustav experimentálnej farmakológie Centra fyziologických vied Slovenskej akadémie vied, Bratislava.
Gibala
P
P
Drímal
J
J
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D005042:Etimizol / Q000494:pharmacology*; D005121:Extremities / Q000098:blood supply; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D011983:Receptors, Purinergic / Q000187:drug effects* / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects*
D007093:Imidazoles; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D000241:Adenosine; D005042:Etimizol
Vazodilatacné úcinky etimizolu in vitro a ich vztah k purínergickým receptorom.