[The membrane sialoglycolipids of tumor cells and the metastasis of bone tumors].
Level and profile of gangliosides were studied in osteogenic and chondrosarcoma cells. Level of lipid-binding sialic acids in bone- and cartilage-producing tumors proved different. Most osteogenic sarcoma samples showed higher level of lipid-binding sialic acids as compared to chondrosarcoma. In the latter tumor, level of lipid-binding sialic acids was related to grade of tumor cell differentiation, peak levels being observed in undifferentiated neoplasms as compared to those showing grade I-II cell anaplasia. Chondro- and osteogenic sarcoma revealed different profiles of sialoglycolipids, particularly, due to markedly reduced set of gangliosides and nearly complete loss of polysialogangliosides in the latter tumor.
Kushlinskiĭ
N E
NE
Novikov
A M
AM
Bassalyk
L S
LS
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000032:analysis*; D002471:Cell Transformation, Neoplastic / Q000032:analysis; D002813:Chondrosarcoma / Q000032:analysis; D005260:Female; D005354:Fibrosarcoma / Q000032:analysis; D005732:Gangliosides / Q000032:analysis; D006017:Glycolipids / Q000032:analysis*; D006801:Humans; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000032:analysis
D005732:Gangliosides; D006017:Glycolipids; D008563:Membrane Lipids; C009255:sialoglycolipids
Sialoglikolipidy membran opukholevykh kletok i metastazirovanie opukholeĭ kosteĭ.