Double blind comparison of transdermal hyoscine and placebo for the prevention of postoperative nausea.
Transdermal hyoscine (Scopoderm, Ciba-Geigy) has been compared with placebo in 283 female patients. The hyoscine patch had no significant effect on postoperative nausea or vomiting. In contrast with earlier studies, there was no correlation between previous experiences of nausea (motion, pregnancy or surgery related) and nausea caused by the surgery or anaesthetic in this study. No correlation was found between nausea or vomiting and the type of operation.
Kuopio University Central Hospital, Finland.
E M
EM
Koski
M A
MA
Mattila
D
D
Knapik
T
T
Toivanen
H
H
Ruusukallio
P
P
Andersson
Y
Y
Freudenthal
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012601:Scopolamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000517:prevention & control
D012601:Scopolamine