N-acetyl-beta-D-glucosaminidase in lymphocytes of patients with diabetes mellitus.
In 55 patients with diabetes mellitus the significant quantitative increase in numbers of N-acetyl-beta-D-glucosaminidase-positive lymphocytes in the peripheral blood has been examined by cytochemical methods. The enzyme-positive lymphocytes of these patients were characterized by prevalence of extralysosomal localization of the enzyme and a decrease in the numbers of those cells having intact enzyme-positive lysosomes. No association between these alterations and therapy with insulin or oral hypoglycemic drug and overweight could be stated.
Lisiewicz
J
J
Moszczyński
P
P
D000118:Acetylglucosaminidase / Q000097:blood*; D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007958:Leukocyte Count; D008214:Lymphocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged
D007004:Hypoglycemic Agents; D007328:Insulin; D006596:Hexosaminidases; D000118:Acetylglucosaminidase