Actinomycin and DNA transcription.
Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.
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D000818:Animals; D002466:Cell Nucleolus / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D008854:Microscopy, Electron; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D014158:Transcription, Genetic / Q000187:drug effects*
D003609:Dactinomycin; D012321:DNA-Directed RNA Polymerases