Pulmonary function responses in cats following long-term exposure to diesel exhaust.
Long-term inhalation studies were carried out to evaluate the toxic pulmonary effects of diesel engine emissions. Cats were exposed for over 2 years to whole, diluted diesel exhaust at levels expected to produce frank toxic effects. During the first 61 weeks of exposure, the cats received exhaust having a particulate level of 6 mg m-3. This was followed by a doubling of the exposure level from weeks 62 to 124 resulting in particulate levels of 12 mg m-3. No definitive pattern of pulmonary function response was observed following 61 weeks; however, a classic pattern of restrictive lung disease was found at 124 weeks. The significantly reduced lung volumes and diffusing capacity were indicative of a pulmonary interstitial response which was later verified by histopathology.
Moorman
W J
WJ
Clark
J C
JC
Pepelko
W E
WE
Mattox
J
J
D000818:Animals; D002415:Cats; D005648:Fuel Oils / Q000032:analysis / Q000633:toxicity*; D008168:Lung / Q000187:drug effects*; D008176:Lung Volume Measurements; D008297:Male; D010578:Petroleum / Q000633:toxicity*; D013997:Time Factors; D001335:Vehicle Emissions / Q000032:analysis / Q000633:toxicity*; D014797:Vital Capacity
D005648:Fuel Oils; D010578:Petroleum; D001335:Vehicle Emissions