[New elements in the structure of binding sites of glucocorticoid-receptor complex in hormone-regulated genes].
An analysis of the structure of DNA sites responsible for binding to glucocorticoid-receptor complex (GlRC) was carried out. The use of the frequency matrices and of a variant of the perception method made it possible to establish that in the GlRC binding site on both sides of the known conservative nucleotide sequence (nucleus) there were additional conservative elements which seemed to be able to modulate the efficiency of GlRC binding. A criterion is worked out for detecting the potential GlRC binding sites in given sequences. It is based on the simultaneous use of several perceptron matrices. The efficiency of detection of GlRC binding sites by means of the proposed criterion is by an order higher than that performed according to the GlRC binding site consensus (Beato et al. [2]).
I A
IA
Seledtsov
V V
VV
Solov'ev
T I
TI
Merkulova
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics*; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008969:Molecular Sequence Data; D011965:Receptors, Glucocorticoid / Q000235:genetics* / Q000378:metabolism; D013045:Species Specificity
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D004247:DNA
Novye élementy v strukture saĭtov sviazyvaniia glikokortikoid-retseptornogo kompleksa v sostave gormonreguliruemykh genov.