Loose patch clamp recording of ionic currents in demyelinated frog nerve fibers.
Ionic currents in demyelinated segments of frog sciatic nerves have been detected by means of a patch clamp technique. Axons were examined 6-13 days after lysolecithin-induced demyelination. Both voltage-gated sodium channels and voltage-gated potassium channels could be demonstrated in the demyelinated axolemma.
S Y
SY
Chiu
P
P
Shrager
J M
JM
Ritchie
D000818:Animals; D003711:Demyelinating Diseases / Q000503:physiopathology*; D007473:Ion Channels / Q000378:metabolism*; D010525:Peripheral Nerves / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D011892:Rana catesbeiana; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium; D011188:Potassium