A model for fast axonal transport.
A model for fast axonal transport is developed in which the essential features are that organelles may interact with mechanochemical cross-bridges that in turn interact with microtubules, forming an organelle-engine-microtubule complex which is transported along the microtubules. Computer analysis of the equations derived to describe such a system show that most of the experimental observations on fast axonal transport can be simulated by the model, indicating that the model is useful for the interpretation and design of experiments aimed at clarifying the mechanism of fast axonal transport.
Blum
J J
JJ
Reed
M C
MC
D000251:Adenosine Triphosphatases / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D001665:Binding Sites; D001693:Biological Transport, Active; D003080:Cold Temperature; D003593:Cytoplasm / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism; D008433:Mathematics; D008870:Microtubules / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D012984:Software
D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases