[Treatment of chronic glomerulonephritis with high doses of intravenous immunoglobulin].
The initial results of the treatment of 8 patients with idiopathic and lupus glomerulonephritis with immunovenin intact are reported. Previously the patients had been treated for a long time with combinations of corticosteroids, immunosuppressors and anticoagulants without effect. All patients had an well expressed nephrotic syndrome, 6 patients had initial chronic renal failure. The immunovenin intact treatment was carried out in three day courses of 85 mg/kg/24 h (a total of 250 mg/kg for one course). All patients received two courses of treatment. The patients were followed up for 3 to 30 months (mean 10.0 +/- 3.29). In 4 patients a full clinical remission was achieved. Two patients, after a satisfactory effect of the treatment, died from non-renal causes. The mechanisms of action of immunovenin intact are discussed.
Belovezhdov
N
N
Monova
D
D
Altŭnkova
I
I
Robeva
R
R
D001379:Azathioprine / Q000627:therapeutic use; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008181:Lupus Nephritis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D008775:Methylprednisolone / Q000008:administration & dosage; D013997:Time Factors
D007074:Immunoglobulin G; D006493:Heparin; D001379:Azathioprine; D008775:Methylprednisolone
Lechenie na khronichnite glomerulonefriti s visoki dozi intravenozen imunoglobulin.