Photodiode array detection for liquid chromatographic profiling of carboxylic acids in physiological fluids: 3-hydroxy-3-methylglutaric aciduria.
3-Hydroxy-3-methylglutaric aciduria was detected in a newborn. The progress of the dietary therapy for the disorder was monitored by dual-column "high-performance" liquid chromatography with a computer-controlled photodiode array spectrophotometric detector. This procedure is a quick way to detect and monitor the progress of 3-hydroxy-3-methylglutaric aciduria.
D N
DN
Buchanan
J G
JG
Thoene
D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D005977:Glutarates / Q000652:urine*; D006801:Humans; D007231:Infant, Newborn; D015093:Meglutol / Q000652:urine*; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000178:diet therapy / Q000652:urine*; D013053:Spectrophotometry / Q000379:methods
D005977:Glutarates; C022034:3-methylglutaconic acid; D015093:Meglutol