[Ion channels in cardiac tissue. Validity and limits of cellular electrophysiology in the interpretation of clinical data].
New experimental methods in cellular electrophysiology allowed the identification and characterization of specific "ion channels" in the plasma membrane of cardiac cells in different regions of the heart. Function and implication of the "ion channels" have been considered in 1) the initiation of the heart-beat, 2) the chronotropic and inotropic effects of neurotransmitters (nor-epinephrine-acetylcholine), 3) the action mechanism of the steroid cardioactive drugs, 4) the cardiac repolarization, 5) the physiopathology of several arrhythmias. Moreover clinical data useful for the indirect evaluation of the ion channels function have been pointed out, stressing the ion channels models contribution for the cardiac pathology interpretation, particularly in the cardiac arrhythmias field.
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Spinnler
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Mangiardi
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Di Francesco
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Ferroni
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D002118:Calcium / Q000378:metabolism; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D009200:Myocardial Contraction; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D000255:Adenosine Triphosphate; D012964:Sodium; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine
I canali ionici nel tessuto cardiaco. Validità e limiti della elettrofisiologia cellulare nell'interpretazione dei dati clinici.