Magnetic localization of a dipolar current source implanted in a sphere and a human cranium.
Magnetic fields produced by a dipolar source implanted in a spherical conductor and a human cranial specimen were measured in the magnetoencephalogram (MEG). The location of the source was accurately computed in the spherical conductor from the identified magnetic field extrema using equations for a current dipole in a sphere. This same method was insufficient for localizing the source in a human cranium, where magnetic field maps appeared as distortions from the classical dipolar pattern. A more complete computer modeling procedure was used, adjusting for the non-spherical dimensions of the recording matrix on the cranium. By fitting the gradient of computer simulated fields to those measured outside the cranium, the accuracy of source localization was substantially improved. The greatest distortion of the extracranial magnetic field was an inequality in the measured amplitude of the two extrema, produced by an increased distance and angle of the MEG probe when recording over the lower face and ear. However, gross heterogeneities in the resistance of the skull due to a craniectomy and an implanted insulating balloon had a negligible effect on the extracranial magnetic field pattern.
D S
DS
Barth
W
W
Sutherling
J
J
Broffman
J
J
Beatty
D001847:Bone Diseases / Q000503:physiopathology; D006801:Humans; D008280:Magnetics; D008722:Methods; D008954:Models, Biological; D012886:Skull / Q000502:physiology*