[The potentiating action of artificial immunodeficiency on the development of amyloidosis in plague in great gerbils].
Cyclophosphamide injection causes amyloidosis development in the spleen of great gerbils both intact and plague-infected after immunization. The amyloid deposits are observed irrespective of acquired antiplague resistance level. Alterations observed may be considered as acquired (secondary) AA-amyloidosis. Results indicate the significance of immunodepression in amyloidogenesis and a possibility to use the cyclophosphamide-treated great gerbils as a convenient experimental model of amyloidosis.
S Iu
SIu
Zadumina
I V
IV
Isupov
D000686:Amyloidosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D010930:Plague / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014774:Virulence; D015010:Yersinia pestis / Q000276:immunology / Q000472:pathogenicity
D003520:Cyclophosphamide
Potentsiruiushchee deĭstvie iskusstvennogo immunodefitsita na razvitie amiloidoza pri chume u bol'shikh peschanok.