[Intracellular sites of corticosteroid hormone action: demonstration of enhanced RNA synthesis in the distal parts of the nephron].
Chronic treatment by deoxycorticosterone acetate (DOCA) is mainly responsible for an increase in uridine incorporation within cells of the cortical and medullary collecting tubules, reflecting an induction of RNA synthesis in segments considered as target sites for corticosteroid hormones.
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Vandewalle
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000187:drug effects*; D007685:Kidney Tubules, Collecting / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013268:Stimulation, Chemical
D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D012313:RNA
Etapes intracellulaires de l'action des hormones corticostéroïdes: mise en évidence d'une stimulation de synthèse d'ARN dans les parties distales du néphron.