Temporal variation in morphine-mast cell interaction.
The possible rhythmic interaction between morphine and mast cell was investigated in mice. It has been found that both at normal and drug-induced state, mast cells varied as a function of time and the number of mast cells was significantly affected at the time in which the number of mast cells was highest over a 24-h period. The exact underlying mechanism of the phenomenon still remains to be investigated.
Polat
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D000818:Animals; D002940:Circadian Rhythm; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*
D009020:Morphine