Synthesis of a new chemically and metabolically stable prostacyclin analogue with high and long-lasting oral activity.
Skuballa
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W
Schillinger
E
E
Stürzebecher
C S
CS
Vorbrüggen
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D000284:Administration, Oral; D000818:Animals; D001667:Binding, Competitive; D001794:Blood Pressure / Q000187:drug effects; D011464:Epoprostenol / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology / Q000031:analogs & derivatives; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D016285:Iloprost; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000378:metabolism
D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D011464:Epoprostenol; D016285:Iloprost; C043867:cicaprost