Naturally occurring flavonoids and human basophil histamine release.
Naturally occurring plant flavonoids, normal dietary constituents, affect a variety of cell activation phenomena including the secretion of histamine from human basophils stimulated by a variety of agents (antigen, anti-IgE, concanavalin A, ionophore A23187, formyl-Met-Leu-Phe and tetradecanoyl phorbol acetate). Variable profiles of inhibition are seen depending on the nature of the stimulus and the chemical structure of flavonoids.
E
E
Middleton
G
G
Drzewiecki
D001491:Basophils / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D005419:Flavonoids / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D013329:Structure-Activity Relationship
D005419:Flavonoids