Disturbed hypothalamic control of Na,K-ATPase: a cause of somatic symptoms of depression.
Current theories of the causes of somatic symptoms in depression neglect evidence for a general inhibition of Na,K-ATPase. Experimentally, sodium pump inhibition is associated with depolarization of electrically active tissue: the threshold of peripheral nerves is decreased and smooth muscle function altered. Symptoms compatible with these changes are found both in depression and intoxication with digoxin, which inhibits Na,K-ATPase. The hypothalamus contains inhibitors of Na,K-ATPase which are capable of producing depolarization. In depression, changes in hypothalamic activity may increase endogenous inhibition and contribute to the somatic symptoms.
J D
JD
Rose
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001693:Biological Transport, Active; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D004077:Digoxin / Q000009:adverse effects; D006168:Guinea Pigs; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology*; D007473:Ion Channels / Q000502:physiology; D008954:Models, Biological; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D007473:Ion Channels; D010042:Ouabain; D004077:Digoxin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase