Serotonin innervation of physiologically identified lamina I projection neurons.
Physiologically characterized lamina I projection neurons, including antidromically activated spinomesencephalic and spinothalamic tract cells, were intracellularly stained with HRP and then processed and examined for serotonin-immunoreactive contacts. We observed cells with both high and low densities of contacts from serotonergic axons. Serotonin contacts were found on both nociceptive-specific and wide-dynamic-range projection neurons. The density of contacts did not appear to correlate with any physiological characteristic.
Hylden
J L
JL
Hayashi
H
H
Ruda
M A
MA
Dubner
R
R
D000818:Animals; D001370:Axonal Transport; D002415:Cats; D004558:Electric Stimulation; D007839:Functional Laterality; D006735:Horseradish Peroxidase; D008636:Mesencephalon / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*
D012701:Serotonin; D006735:Horseradish Peroxidase