Renal preservation following severe ischemia and prophylactic calcium channel blockade.
The ability of the calcium channel blocker verapamil to prevent renal ischemic damage was assessed in a randomized double blind study of 41 rats. Study animals received either intravenous verapamil or placebo prior to renal pedicle occlusion and contralateral nephrectomy. Rats receiving verapamil pretreatment demonstrated significantly greater functional preservation 48 hours after ischemia (p less than 0.005) and exhibited better overall survival rates. In this study verapamil provided protection against renal damage following ischemia.
G A
GA
Gingrich
G R
GR
Barker
P
P
Lui
S C
SC
Stewart
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003404:Creatinine; D004311:Double-Blind Method; D007473:Ion Channels / Q000187:drug effects*; D007511:Ischemia / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D011292:Premedication; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D007473:Ion Channels; D003404:Creatinine; D014700:Verapamil; D002118:Calcium