Role of the spinal monoaminergic systems in suppression of ejaculation by alpha-methyldopa.
Alpha-methyldopa causes inhibition of ejaculation by suppressing the dopaminergic system in the brain. The spinal mechanism which works together with this brain inhibitory mechanism was persued by determining the changes of spinal monoamines in dogs. As a result, it was found that suppression of the dopaminergic system by alpha-methyldopa is caused also in the spinal cord just as in the brain and that this suppression can be a direct origin of the inhibition of ejaculation.
Kimura
Y
Y
Tadano
T
T
Urano
S
S
Yonezawa
A
A
Watanabe
H
H
Kisara
K
K
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism / Q000502:physiology*; D004285:Dogs; D004298:Dopamine / Q000378:metabolism; D004542:Ejaculation / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D013116:Spinal Cord / Q000378:metabolism*
D001679:Biogenic Amines; D012701:Serotonin; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D008750:Methyldopa; D001545:Benserazide; D004298:Dopamine; D009638:Norepinephrine