[The value of cytoreductive second-look surgery in advanced epithelial ovarian carcinoma].
40 patients with advanced epithelial ovarian carcinoma were investigated to evaluate the influence of further cytoreduction during second-look surgery on survival after termination of first-line polychemotherapy containing cisplatinum. Radical tumorectomy with no macroscopic residual tumor mass was achieved in 27.5% of cases; in 52.5% the residual tumour mass was less than 2 cm and in 20% it was more than 2 cm in diameter after cytoreductive second-look surgery. Median survival time after second-look within these three groups of patients was 15.2 months, 16.9 months and 15.3 months, respectively (Mantel test, p = 0.74). In contrast to the situation at the diagnostic operation, further cytoreduction during second-look surgery has no positive influence on survival. We therefore abandoned this operation in clinically tumour-positive patients.
Gynäkologisch-onkologische Arbeitsgruppe der I. Universitäts-Frauenklinik, Wien.
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P
Sevelda
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M
Barrada
N
N
Vavra
U
U
Denison
S
S
Schmidl
H
H
Genger
H
H
Salzer
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007813:Laparotomy / Q000379:methods*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012086:Reoperation
Die Wertigkeit der zytoreduktiven Second-look-Operation beim forgeschrittenen epithelialen Ovarialkarzinom.