Mechanisms of glucocorticoid action in pulmonary disease.
This article reviews the multiple mechanisms by which glucocorticoids influence the pathophysiology of pulmonary disease. Particular emphasis is given to the influence of glucocorticoids on the release and action of mediators that promote inflammation and that modulate other pathophysiologic processes in the lung. The time course and mechanisms of action that contribute to glucocorticoid effects on pulmonary function are also discussed.
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D000818:Animals; D017302:Annexins; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D002135:Calcium-Binding Proteins; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors; D005938:Glucocorticoids / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006023:Glycoproteins / Q000096:biosynthesis; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000096:biosynthesis; D014176:Protein Biosynthesis; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism; D013224:Status Asthmaticus / Q000188:drug therapy / Q000503:physiopathology
D017302:Annexins; D001095:Arachidonic Acids; D002135:Calcium-Binding Proteins; D002630:Chemotactic Factors; D005938:Glucocorticoids; D006023:Glycoproteins; D010972:Platelet Activating Factor; D011965:Receptors, Glucocorticoid; C030958:lipomodulin; D016718:Arachidonic Acid