Eudismic analysis of a series of muscarinic ligands carrying a 1,3-oxathiolane nucleus.
Eudismic analysis was performed on a set of 14 muscarinic ligands carrying a 1,3-oxathiolane nucleus, in order to obtain information about both the existence of receptor subgroups and of agonist and competitive antagonist interaction sites. The results obtained were compared with those from a study of the enantioselectivity of the pairs of enantiomers. The two approaches do not appear to be completely equivalent and would seem to complement each other usefully.
Department of Medicinal Chemistry, University of Florence, Italy.
F
F
Gualtieri
M N
MN
Romanelli
E
E
Teodori
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000378:metabolism*; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009206:Myocardium / Q000378:metabolism; D010277:Parasympathomimetics / Q000138:chemical synthesis / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000145:classification; D012044:Regression Analysis; D013237:Stereoisomerism; D013876:Thiophenes
D006571:Heterocyclic Compounds; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; D013876:Thiophenes; C013177:1,3-oxathiolane