Effect of gemfibrozil on the concentration and composition of serum lipoproteins. A controlled study with special reference to initial triglyceride levels.
We investigated the modulating effect of serum total triglycerides on the lipid composition of various lipoproteins, and on the response to gemfibrozil treatment. This placebo controlled study was conducted blind in 60 participants of the Helsinki Heart Study. An inverse relationship was observed between cholesterol content in all lipoprotein fractions and serum total triglyceride level. Gemfibrozil, in addition to changing the absolute amounts of lipoprotein lipids, also normalized the qualitative abnormalities associated with hypertriglyceridemia. Gemfibrozil increased the level of HDL-cholesterol with the main effect on HDL3-subfraction. The observed reduction in LDL-cholesterol was dependent on the initial triglyceride level.
First Department of Medicine, University of Helsinki, Finland.
M
M
Mänttäri
P
P
Koskinen
V
V
Manninen
J K
JK
Huttunen
M H
MH
Frick
E A
EA
Nikkilä
D008076:Cholesterol, HDL / Q000097:blood; D002986:Clinical Trials as Topic; D015248:Gemfibrozil / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D010919:Placebos; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D008074:Lipoproteins; D010919:Placebos; D014280:Triglycerides; D015248:Gemfibrozil