The effect of cyclophosphamide on the Peyer's patches in MRL1/1 and NZB/WF1 mice.
MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.
Department of Pathology, Faculty of Medicine, Kyoto University, Japan.
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Yoshioka
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Sugiyama
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Kita
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002470:Cell Survival; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007150:Immunohistochemistry; D007958:Leukocyte Count; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D010581:Peyer's Patches / Q000187:drug effects / Q000473:pathology*; D013601:T-Lymphocytes
D000954:Antigens, Surface; D003520:Cyclophosphamide