Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis.
Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.
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U
Jahnke
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Fischer
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Alvord
D000818:Animals; D001483:Base Sequence; D002645:Chickens; D004679:Encephalomyelitis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D000939:Epitopes; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D008457:Measles / Q000378:metabolism; D004676:Myelin Basic Protein / Q000235:genetics; D018996:Myelin P2 Protein; D009443:Neuritis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D014764:Viral Proteins / Q000235:genetics*; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology
D000939:Epitopes; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D014764:Viral Proteins; D014765:Viral Vaccines