[Study of the nature of regulation of potential-dependent channels by Raman spectroscopy].
The light scattering spectra of frog somatic nerves during excitation, its block by tetrodotoxin and at different Ca2+ and H+ extracellular concentrations have been investigated. In all cases changes were observed in the C40-carotenoid peaks enhanced by the resonance Raman effect. These changes can be explained by transient carbon-carbon bond equalization of the polyene chain. The mechanism of regulation of Na-channel function by "potential-sensor" in relation to the excitable membrane was discussed.
Maksimov
G V
GV
Churin
A A
AA
Pashchenko
V Z
VZ
Rubin
A B
AB
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002338:Carotenoids / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008563:Membrane Lipids / Q000378:metabolism*; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology*; D012964:Sodium / Q000378:metabolism; D013059:Spectrum Analysis, Raman; D013779:Tetrodotoxin / Q000494:pharmacology
D002712:Chlorides; D007473:Ion Channels; D008563:Membrane Lipids; D002338:Carotenoids; D013779:Tetrodotoxin; D004533:Egtazic Acid; D008094:Lithium; D012964:Sodium; D018021:Lithium Chloride
Issledovanie prirody reguliatsii potentsialzavisimykh kanalov metodom spektroskopii kombinatsionnogo rasseianiia.