Cardiovascular and renal effects of the beta-blocker SE2395 in conscious normotensive dogs.
The cardiac and renal hemodynamic effects of SE2395, a beta-blocking agent, were examined after intravenous administration (50 micrograms/kg) in normotensive conscious dogs. Beta-blocking action of SE2395 was evidenced by a reduction in heart rate and cardiac output without change in the mean arterial pressure. An increase in glomerular filtration rate (inulin clearance) and a slight enhancement in effective renal plasma flow (para-aminohippurate clearance) were observed without attendant decreases in plasma renin activity. An increase in urinary sodium excretion was also observed; urinary prostaglandin E2 excretion was, however, unchanged. We conclude that at effective beta-blocking dosage SE2395 does not induce any detrimental effect on renal function in conscious dogs.
Walker
B R
BR
Erickson
A L
AL
Prost
J F
JF
Rochat
C
C
Burke
T J
TJ
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D015232:Dinoprostone; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000187:drug effects*; D007444:Inulin; D007668:Kidney / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D011412:Propanolamines / Q000494:pharmacology*; D011458:Prostaglandins E / Q000652:urine; D011652:Pulmonary Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013876:Thiophenes; D014655:Vascular Resistance / Q000187:drug effects; D010130:p-Aminohippuric Acid / Q000652:urine
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011458:Prostaglandins E; D013876:Thiophenes; D007444:Inulin; D012964:Sodium; C005632:tertatolol; D012083:Renin; D015232:Dinoprostone; D011188:Potassium; D010130:p-Aminohippuric Acid