Chlorpromazine attenuates the pulmonary vascular response to isocapneic alveolar hypoxia in piglets.
We investigated the cardiovascular effects of chlorpromazine (CPZ) during normoxia and during alveolar hypoxia (HYP) in 9 chronically instrumented piglets aged 10-14 days. Each animal was instrumented for measurements of pulmonary and systemic arterial and left atrial pressures and pulmonary blood flow. Each piglet was studied three times: once during normoxia following infusions of normal saline (NS) and CPZ (1 mg/kg), once during established HYP (10% O2-2.5% CO2) following the infusion of NS and a third time during established HYP following the infusion of CPZ (1 mg/kg). CPZ did not alter any of the cardiovascular variables during normoxia but decreased the pulmonary arterial pressure and pulmonary vascular resistance during HYP. Thus, CPZ is a vasodilator in the pulmonary vascular bed of piglets, preconstricted by HYP.
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
G G
GG
Konduri
J E
JE
Fewell
B J
BJ
Taylor
D E
DE
Hill
D000818:Animals; D001784:Blood Gas Analysis; D002746:Chlorpromazine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects*; D013552:Swine
D002746:Chlorpromazine