Human chorionic gonadotropin in normal, inflammatory, and carcinomatous gastric tissue.
Tissues from 12 patients with gastric ulcers, 50 patients with gastric carcinoma, and 2 normal subjects who died suddenly were examined immunohistochemically with antiserum against the beta-subunit of human chorionic gonadotropin. Human chorionic gonadotropin-beta-immunoreactive cells were present in the neck portion of the pyloric and pseudopyloric glands of normal and inflammatory gastric tissue. Gastric cancers located in the antrum-pylorus and the cardia were frequently associated with human chorionic gonadotropin immunoreactivity. These findings indicate that human chorionic gonadotropin-producing cells normally exist in the gastric mucosa, especially in the pylorus. It is speculated that normal human chorionic gonadotropin-producing cells may give rise to cancer in certain cases.
Manabe
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Adachi
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Hirao
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K
D000230:Adenocarcinoma / Q000032:analysis; D002288:Adenocarcinoma, Mucinous / Q000032:analysis; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis*; D005757:Gastritis, Atrophic / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis*; D013274:Stomach Neoplasms / Q000032:analysis* / Q000473:pathology; D013276:Stomach Ulcer / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments