Structure of a cloned circular retroviral DNA containing a tRNA sequence between the terminal repeats.
In the course of analyzing a series of cloned circular retroviral DNAs, we recovered an unusual clone. The molecule consisted of a complete viral genome containing two copies of the long terminal repeat with extra sequences between the repeats. These extra bases proved to be a nearly complete DNA copy of a glycine tRNA, including bases that corresponded to modified and nonpairing bases of the mature tRNA. A model is proposed to account for the formation of the aberrant clone.
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J
Colicelli
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SP
Goff
D003001:Cloning, Molecular; D004279:DNA, Viral / Q000235:genetics*; D008040:Genetic Linkage; D005998:Glycine; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009690:Nucleic Acid Conformation; D012343:RNA, Transfer / Q000235:genetics*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid
D004279:DNA, Viral; D012343:RNA, Transfer; D012194:RNA-Directed DNA Polymerase; D005998:Glycine