Nucleolar organizer regions in patients with precancerous and cancerous lesions of the uterine cervix.
Nucleolar organizer regions (Ag-NORs) were studied in patients with cervical precancerous and cancerous lesions along with controls. The data revealed a statistically significant decrease of Ag-NORs in cancer patients, as well as in women with severe precancerous lesions as compared with controls. A similar decrease in the amount of Ag-staining was also observed in both cancer and severe dysplasia cases. The study suggests a possible relationship of Ag-NOR activity to malignancy.
Murty
V V
VV
Mitra
A B
AB
Sharma
J K
JK
Luthra
U K
UK
D000328:Adult; D000368:Aged; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D012834:Silver; D013194:Staining and Labeling; D002578:Uterine Cervical Dysplasia / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
D012834:Silver