Human alpha 2-macroglobulin gene is located on chromosome 12.
A cDNA clone encoding amino acids 809-1451 of the protease inhibitor alpha 2-macroglobulin has been isolated from an adult human liver cDNA library. This cDNA was used to examine DNA samples prepared from a panel of human-mouse somatic cell hybrids with different numbers and combinations of human chromosomes for the presence of the human alpha 2-macroglobulin gene. The cosegregation of this gene and chromosome 12 in the cell hybrid panel indicated that the alpha 2-macroglobulin structural gene (designated A2M) is on human chromosome 12.
G I
GI
Bell
L B
LB
Rall
R
R
Sanchez-Pescador
J P
JP
Merryweather
J
J
Scott
R L
RL
Eddy
T B
TB
Shows
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins; D004247:DNA; D004262:DNA Restriction Enzymes