Eudismic analysis of a series of muscarinic ligands carrying a 1,3-oxathiolane nucleus.
Eudismic analysis was performed on a set of 14 muscarinic ligands carrying a 1,3-oxathiolane nucleus, in order to obtain information about both the existence of receptor subgroups and of agonist and competitive antagonist interaction sites. The results obtained were compared with those from a study of the enantioselectivity of the pairs of enantiomers. The two approaches do not appear to be completely equivalent and would seem to complement each other usefully.
Gualtieri
F
F
Department of Medicinal Chemistry, University of Florence, Italy.
Romanelli
M N
MN
Teodori
E
E
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000378:metabolism*; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009206:Myocardium / Q000378:metabolism; D010277:Parasympathomimetics / Q000138:chemical synthesis / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000145:classification; D012044:Regression Analysis; D013237:Stereoisomerism; D013876:Thiophenes
D006571:Heterocyclic Compounds; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic; D013876:Thiophenes; C013177:1,3-oxathiolane