The adherence of Staphylococcus aureus to human corneocytes.
Staphylococcus aureus has a peculiar ability to colonize the skin of patients with atopic dermatitis. We examined the possibility that this might be due to a specific ability of this pathogenic staphylococcus to adhere to atopic stratum corneum. We used an in vitro model to show that S aureus does have an unusual ability to adhere to atopic corneocytes when compared with corneocytes obtained from patients with other cutaneous diseases, including psoriasis. Protein A--a component of the staphylococcal cell wall--may be responsible in part for this adherence phenomenon. This trait did not extend to the other gram-positive bacteria tested.
Cole
G W
GW
Silverberg
N L
NL
D002455:Cell Division; D003876:Dermatitis, Atopic / Q000382:microbiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007633:Keratins / Q000032:analysis*; D008070:Lipopolysaccharides; D010712:Phosphatidic Acids / Q000032:analysis; D012867:Skin / Q000382:microbiology; D013205:Staphylococcal Protein A / Q000032:analysis; D013211:Staphylococcus aureus / Q000032:analysis / Q000502:physiology*; D013682:Teichoic Acids / Q000032:analysis; D013696:Temperature
D008070:Lipopolysaccharides; D010712:Phosphatidic Acids; D013205:Staphylococcal Protein A; D013682:Teichoic Acids; C009900:lipoteichoic acid; D007633:Keratins