Control of lymphokine production by protein kinase C.
As illustrated in Fig. 3, our understanding of lymphokine production is incomplete. Nuclear effects of PKC are probably mediated by phosphorylated substrates. Some of the substrates are themselves being identified as kinases and phosphatases, adding more complexity to the pathway. Use of resistant cell lines is one of the approaches that may help link early phosphorylation events with later transcriptional responses.
Department of Pharmacology and Cancer Center, Univ. of Virginia, Charlottesville 22908.
J J
JJ
Sando
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Homan
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Jensen
D000818:Animals; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D011493:Protein Kinase C / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism*; D013945:Thymoma / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D008222:Lymphokines; D011493:Protein Kinase C