HIV-1 infection: no evidence of cognitive decline during the asymptomatic stages. The Multicenter AIDS Cohort Study.
Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfected controls in the Multicenter AIDS Cohort Study with neuropsychological testing at semiannual intervals. A comparison of change in scores between visits 1 and 4 as well as a multivariate autoregressive analysis revealed no evidence of decline in test performance over time in the HIV-1-infected group compared with the seronegative controls. These findings suggest that a gradual cognitive decline does not occur during the early, asymptomatic stages of HIV infection.
Selnes
O A
OA
Johns Hopkins Medical Institutions, Baltimore, MD.
Miller
E
E
McArthur
J
J
Gordon
B
B
Muñoz
A
A
Sheridan
K
K
Fox
R
R
Saah
A J
AJ
D000328:Adult; D003071:Cognition; D015331:Cohort Studies; D015658:HIV Infections / Q000503:physiopathology / Q000523:psychology*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011597:Psychomotor Performance; D019966:Substance-Related Disorders / Q000523:psychology