[Effect of Expafusion (HES 40/0.5) on the corpuscular elements of blood and inhibitors of blood coagulation].
The present study reports on an investigation of 32 normal subjects who were given intravenously 500 ml of hydroxyethyl starch (HES) over 30 min. In 16 normal subjects, 500 ml of blood had been previously withdrawn over 20 min. Tolerance proved to be good. Side effects such as hyperergic reactions, influence on circulatory or cardiac function were not observed. Changes in corpuscular elements of blood did not exceed the dilution effect and mostly returned to the initial value 60 min after termination of HES infusion. The change in thrombocyte function, immunoglobulins and the inhibitors alpha 1-antitrypsin, alpha 2-macroglobulin, as well as C1-inactivator and C3-activator only slightly, but not more pronounced than it could have been expected by the dilution effect. A favorable effect could be recorded in erythrocyte filtration according to Schmidt-Schoenbein. Here, we found an improved flow property which exceeded the hemodilution effect and lasted over the 4-hour test period. In addition, thrombocyte aggregation during ADP administration in the Born chamber did not show any change which suggests that a clinically relevant effect on thrombocyte function and thus the danger of hemorrhage during HES administration can be excluded.
H
H
Köstering
J
J
Giffhorn
B
B
Negendank-Damenz
D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects*; D003166:Complement Activating Enzymes / Q000097:blood*; D003174:Complement C1 Inactivator Proteins / Q000097:blood*; D050577:Complement C3-C5 Convertases / Q000097:blood*; D004907:Erythrocyte Deformability / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D007136:Immunoglobulins / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects; D013213:Starch / Q000031:analogs & derivatives*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D003174:Complement C1 Inactivator Proteins; D006895:Hydroxyethyl Starch Derivatives; D007136:Immunoglobulins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D013213:Starch; D003166:Complement Activating Enzymes; D050577:Complement C3-C5 Convertases
Einfluss von Expafusin (HAS 40/0.5) auf die korpuskulären Anteile des Blutes und die Inhibitoren der Blutgerinnung.