Inhibitory effect of a novel anticomplementary agent, K-76COONa, on the release of histamine induced by zymosan and compound 48/80.
A novel sesquiterpene anticomplementary agent, K-76COONa, if locally applied, was revealed to have an activity to prevent histamine release from rat connective tissue mast cells not only in a zymosan-induced inflammation of the air pouch type (zymosan-air-pouch inflammation) but also in compound 48/80-induced air-pouch inflammation. Moreover, K-76COONa inhibited in vitro histamine release from rat peritoneal mast cells induced by compound 48/80.
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D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002478:Cells, Cultured; D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D010537:Peritoneum; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000494:pharmacology*; D015054:Zymosan; D003189:p-Methoxy-N-methylphenethylamine
D003169:Complement Inactivator Proteins; D012717:Sesquiterpenes; D003189:p-Methoxy-N-methylphenethylamine; C038797:K 76 carboxylic acid; D015054:Zymosan