Dihydropyridine Ca2+ agonists and channel blockers interact in the opposite manner with photogenerated unpaired electrons.
Interaction of Ca2+-channel antagonists (felodipine, ryocidil, verapamil, diltiazem) and agonists (dihydropyridine derivatives Bay K 8644 and CGP 28392) was studied by the methods of absorption spectroscopy. Ca2+-channel antagonists were found to act as electron donors, the agonists being electron acceptors in the interaction with dye free radicals in solution. Redox transitions in channel-forming protein were proposed as a possible mechanism of the modulation of channel activity by the compounds tested.
B S
BS
Marinov
M E
ME
Saxon
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D004801:Eosine Yellowish-(YS); D006418:Heme / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D009211:Myoglobin / Q000378:metabolism; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014907:Whales
D002121:Calcium Channel Blockers; D007473:Ion Channels; D009211:Myoglobin; D011725:Pyridines; D006418:Heme; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; C040525:CGP 28392; D009543:Nifedipine; D004801:Eosine Yellowish-(YS)