The mammary gland as a target organ for infection with caprine arthritis-encephalitis virus.
A herd of 15 dairy goats with a previous history of neurological disease in kids was screened for caprine arthritis-encephalitis (CAE) virus infection. Virus was isolated from the PBL of all animals as well as milk from lactating does. All animals had antibody detected by ELISA and gel immuno-diffusion. Two animals from this herd were examined for responses to infection. One was an adult female with poor milk production and the other was a 3-month-old female kid which developed acute neurological disease. Both animals had a chronic mastitis compatible with a viral aetiology, and CAE virus was isolated from the mammary tissue of both. The mammary gland must thus be considered an important target organ for virus infection and dissemination.
Kennedy-Stoskopf
S
S
Narayan
O
O
Strandberg
J D
JD
D000820:Animal Diseases / Q000382:microbiology* / Q000473:pathology; D000818:Animals; D001170:Arthritis, Infectious / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006041:Goats; D008214:Lymphocytes / Q000166:cytology / Q000382:microbiology; D008297:Male; D008321:Mammary Glands, Animal / Q000382:microbiology* / Q000473:pathology; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
D012194:RNA-Directed DNA Polymerase