Vascular outgrowths from tissue explants embedded in fibrin or collagen gels: a simple in vitro model of angiogenesis.
Explants of muscular and adipose tissue embedded in a three-dimensional matrix of fibrin or collagen fibrils give rise to an extensive outgrowth of branching and anastomosing capillary-like tubes. This culture system provides a simple in vitro model for the study of angiogenesis.
Montesano
R
R
Mouron
P
P
Orci
L
L
D000273:Adipose Tissue / Q000098:blood supply; D000818:Animals; D002196:Capillaries / Q000502:physiology; D002470:Cell Survival; D003094:Collagen; D003470:Culture Media; D046508:Culture Techniques / Q000379:methods; D004727:Endothelium / Q000502:physiology; D005337:Fibrin; D005782:Gels; D009132:Muscles / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D051381:Rats; D013997:Time Factors
D003470:Culture Media; D005782:Gels; D005337:Fibrin; D003094:Collagen