Teleocidin, a tumour promoter, stimulates synthesis of primate retroviruses in persistently infected human cells.
The naturally occurring tumour promoter teleocidin produces a pronounced but transient enhancement of the synthesis of extracellular viral particles in human cells chronically infected with simian retroviruses of type C (baboon endogenous virus, simian sarcoma virus) or type D (Mason-Pfizer monkey virus) or a human cell line-derived type D isolate (PMF virus), respectively. The retrovirus-stimulating activity of teleocidin is very similar to that previously described for the tumour-promoting phorbol ester TPA in the same cell systems.
Wunderlich
V
V
Sydow
G
G
Baumbach
L
L
Fujiki
H
H
D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D008235:Lyngbya Toxins / Q000494:pharmacology*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D002273:Carcinogens; D008235:Lyngbya Toxins; C022176:teleocidins; D012194:RNA-Directed DNA Polymerase