[Endogenous peptides in the organization of somato-vegetative responses to hypothalamic stimulation].
The effect of i. v. administration of angiotensin II, substance P, DSIP, B-endorphin and bradykinin on the behaviour and the somato-vegetative responses to electrical stimulation of negative and positive emotiogenic regions of the hypothalamus, were studied. Angiotensin II, substance P and DSIP suppressed the avoidance and self-stimulation responses and inhibited cardiovascular responses. Bradykinin, renin and B-endorphin increased the latency of avoidance responses, enhanced and prolonged the somato-vegetative responses to electrical stimulation of negative emotiogenic regions of the hypothalamus. Possible mechanisms of the peptides physiological activity are discussed.
Badikov
V I
VI
Burchuladze
R A
RA
Gabuniia
A E
AE
Kashmanov
S I
SI
Fedianina
N G
NG
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D002682:Chinchilla; D003701:Delta Sleep-Inducing Peptide; D004723:Endorphins / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D012083:Renin / Q000494:pharmacology; D012653:Self Stimulation / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology; D001615:beta-Endorphin
D004723:Endorphins; D009842:Oligopeptides; D010455:Peptides; D000804:Angiotensin II; D013373:Substance P; D001615:beta-Endorphin; D003701:Delta Sleep-Inducing Peptide; D012083:Renin; D001920:Bradykinin
Endogennye peptidy v organizatsii somatovegetativnykh reaktsiĭ pri stimuliatsii gipotalamusa.