Effect of N-beta-phenyl ethyl anthranilic acid on macromolecular synthesis during outgrowth of Bacillus subtilis hcr-9 spores.
The rate of protein, RNA and DNA synthesis was measured during the outgrowth of Bacillus subtilis hcr-9 spores in the presence of N-beta-phenyl ethyl anthranilic acid (NBPEA). The rate of incorporation of 14C-amino acids into proteins, 3H-uridine into RNA and methyl 3H-thymidine into DNA was totally inhibited in the presence of concentrations of NBPEA greater than 4.0 mM in the growth medium, resulting in cessation of spore growth.
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D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D001426:Bacterial Proteins / Q000096:biosynthesis*; D004269:DNA, Bacterial / Q000096:biosynthesis*; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013171:Spores, Bacterial / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D062367:ortho-Aminobenzoates; C019126:enfenamic acid