[Membranes of subcellular organelles as the source of superoxide radicals in liver ischemia].
O2-generation rate (Vo2-) in microsomal, mitochondrial and nuclei liver membranes was measured by ESR method, by accumulation of stable nitroxide radicals. These Vo2- values were compared with Cu, ZnSOD and MnSOD activities after 2 hours ischemia and 24 hours reoxygenation. O2- radicals generated by electron transfer chains are concluded to damage mainly during the ischemia, but not the reoxygenation.
Vartanian
L S
LS
Rashba
Iu E
IuE
Nagler
L G
LG
Zgurskiĭ
A A
AA
Oktiabr'skaia
L A
LA
Bilenko
M V
MV
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D005609:Free Radicals; D006498:Hepatectomy; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D008566:Membranes / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D015388:Organelles / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D013482:Superoxide Dismutase / Q000378:metabolism*
D005609:Free Radicals; D013482:Superoxide Dismutase
Membrany subkletochnykh organell kak istochnik superoksidnykh radikalov pri ishemii pecheni.