Ampicillin pharmacokinetics in Indian geriatric subjects.
Ampicillin elimination was studied in geriatric and younger subjects, 10 in each group. The geriatric subjects had higher serum concentration and elimination half-life of the drug. The plasma clearance and urinary excretion of the drug were significantly reduced in them when compared to younger subjects. Urinary excretion of the drug had significant correlation with creatinine clearance of the subjects.
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
R
R
Raveendran
C
C
Adithan
G
G
Sriram
M
M
Krishnan
J S
JS
Bapna
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000667:Ampicillin / Q000493:pharmacokinetics*; D003906:Developing Countries; D006801:Humans; D007194:India; D008875:Middle Aged; D012016:Reference Values
D000667:Ampicillin