Structural cardiac abnormalities in the fetus: reliability of prenatal diagnosis and outcome.
The outcomes of 129 pregnancies in which the fetus was found to have a structural cardiac abnormality are reviewed. Over a 30-month period from January 1985 to June 1987, 1924 patients were referred to the British Heart Foundation Research Centre for Perinatal Cardiology at Guy's Hospital for fetal cardiac scanning. A total of 129 structural cardiac abnormalities was diagnosed; 53% of these patients were referred because of an abnormal 'four-chamber view' on ultrasound at the referring hospital; 47 of the pregnancies (69% of the 68 patients referred before 28 weeks) were terminated, and in the remaining 82 pregnancies outcome was poor with only 20 infants (16%) surviving longer than 11 months. The prenatal diagnosis was fully or partly correct in 96% of the 111 cases where it was possible to verify the diagnosis by post-mortem or postnatal diagnosis. In the 82 pregnancies not terminated, 13 of the 22 cases given a moderate or good prognosis survived more than 11 months (59% survival), but only seven of the 60 (12% survival) given a fatal, poor or uncertain prognosis. The benefits of a multidisciplinary approach are discussed.
Department of Obstetrics and Gynaecology, Guy's Hospital, London.
G K
GK
Davis
C M
CM
Farquhar
L D
LD
Allan
D C
DC
Crawford
M G
MG
Chapman
D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005318:Fetal Heart / Q000002:abnormalities*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007621:Karyotyping; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis; D015203:Reproducibility of Results; D014463:Ultrasonography