Lithium uptake rate and lithium: lithium exchange rate in human erythrocytes at a nearly pharmacologically normal level monitored by 7Li NMR.
7Li NMR was used to follow the rate of uptake of Li+ and Li+:Li+ exchange rates in human erythrocytes at an external lithium concentration of 2 mM, marginally higher than used in therapeutic applications of lithium. The rate of Li+:Li+ exchange is approximately 16 times faster than the rate of Li uptake from the medium. The results are in agreement with lithium-sodium countertransport being the dominant mode for lithium uptake into erythrocytes and for the countertransport system having a greater affinity for Li+ than for Na+.
Department of Chemistry, University of St. Andrews, U.K.
F G
FG
Riddell
A
A
Patel
M S
MS
Hughes
D001692:Biological Transport; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007554:Isotopes; D008094:Lithium / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy
D007554:Isotopes; D008094:Lithium