Relation of plasma renin to end organ damage and to protection of K+ feeding in stroke-prone hypertensive rats.
We studied the effects of regular diet (0.35% NaCl/1.1% potassium), high sodium diet (4% NaCl/0.75% potassium), or high sodium and high potassium diet (4% NaCl/2.11% potassium) on blood pressure, plasma renin activity, renal and cerebrovascular lesions, and incidence of stroke and mortality in male stroke-prone spontaneously hypertensive rats (SHRSP). In the first 4 weeks, the rise in blood pressure was higher in high NaCl than in high NaCl/high potassium or regular diet groups. However, by 8 and 12 weeks, the blood pressure in all three groups was similar. After 4 weeks of diet, plasma renin activity was similar in the three groups (3.4 +/- 0.8, 4.1 +/- 0.9, and 5.2 +/- 1.6 ng/ml/hr, in high NaCl, high NaCl/high potassium, and regular diet groups, respectively) and were not related to sodium excretion. After 8 weeks, plasma renin activity was significantly increased only in the high NaCl group (13.7 +/- 3.7 ng/ml/hr), and by 12 weeks plasma renin activity was significantly higher in the high NaCl group (25.3 +/- 3.6 ng/ml/hr) than in the high NaCl/high potassium (11.1 +/- 2.9 ng/ml/hr) or in the regular diet (7.8 +/- 4.6 ng/ml/hr) groups. Moderate to severe renal vascular lesions were first detected in the high NaCl group by 8 weeks of diet. At 12 weeks, renal vascular damage index (RVDI), estimated histologically, was significantly higher in the high NaCl group (RVDI = 79 +/- 14) than in the high NaCl/high potassium (RVDI = 40 +/- 11) and regular diet (RVDI = 7.8 +/- 4.6) groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Medicine, Cornell University Medical College, New York, New York.
M
M
Volpe
M J
MJ
Camargo
F B
FB
Mueller
W G
WG
Campbell
J E
JE
Sealey
M S
MS
Pecker
R E
RE
Sosa
J H
JH
Laragh
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D004032:Diet; D007668:Kidney / Q000473:pathology; D008297:Male; D011188:Potassium / Q000008:administration & dosage* / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine
D012964:Sodium; D012083:Renin; D011188:Potassium