Early changes in immune parameters induced by an acute nonantigenic inflammation in mouse: influence of imuthiol.
Calcium pyrophosphate (CaPP)-induced pleurisy, may represent one of the simplest expressions of inflammation in that the irritant is a non-diffusible, non-antigenic and non-pyrogenic agent. Spleen or lymph node T or B cell numbers and activities, as well as NK activity, were modified at distance by CaPP-pleurisy. An intense increase in blood polymorphonuclear cells was also triggered by the inflammatory process. Treatment with imuthiol (sodium diethyldithiocarbamate), an agent known to be active on the T-cell lineage, restored towards control values the inflammatory response and tended to normalize white blood cell percentages altered by the inflammatory process. The findings suggest imuthiol could be employed as a virtually nontoxic and non-steroidal anti-inflammatory agent.
M
M
Renoux
J P
JP
Giroud
I
I
Florentin
J M
JM
Guillaumin
D
D
Degenne
G
G
Renoux
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D001772:Blood Cell Count; D002478:Cells, Cultured; D004050:Ditiocarb / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D007107:Immune System / Q000187:drug effects*; D007249:Inflammation / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D007372:Interferons / Q000097:blood; D007694:Killer Cells, Natural / Q000187:drug effects; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects; D013859:Thiocarbamates / Q000627:therapeutic use*
D013859:Thiocarbamates; D007372:Interferons; D004050:Ditiocarb