No evidence for genetic linkage of Gilles de la Tourette syndrome on chromosomes 7 and 18.
Gilles de la Tourette syndrome is a heritable neuropsychiatric disorder. In order to determine the chromosomal localisation of the locus involved, genetic linkage studies were initiated in six extended families. The Gilles de la Tourette gene has been tentatively assigned to chromosome 18q22.1. In our present study no evidence for genetic linkage on chromosome 18 and chromosome 7 was obtained. Data from the markers tested made it possible to exclude the whole of chromosome 18 and the chromosome 7q21.3-qter region as a site for the Gilles de la Tourette gene.
Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands.
P
P
Heutink
B J
BJ
van de Wetering
G J
GJ
Breedveld
J
J
Weber
L A
LA
Sandkuyl
E J
EJ
Devor
A
A
Heiberg
M F
MF
Niermeijer
B A
BA
Oostra
D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D002897:Chromosomes, Human, Pair 7; D004247:DNA / Q000032:analysis; D008040:Genetic Linkage; D005819:Genetic Markers / Q000032:analysis; D006801:Humans; D007407:Interviews as Topic; D010375:Pedigree; D005879:Tourette Syndrome / Q000235:genetics*; D014178:Translocation, Genetic
D005819:Genetic Markers; D004247:DNA