[Concept of tumor promoters in hepatocarcinogenesis].
Tumor promotion is defined as 1 step of carcinogenesis. Its intervention occurred when cell DNA was already damaged by a carcinogen and is the support of quiescent mutations. This leads to a complete malignant transformation of the cells by a non genotoxic mechanism. The presence of tumor promoters in our environment, although difficult to estimate, must be taken into account. This requires further research.
Laboratoire de pathologie cellulaire, CNRS, Institut de recherches scientifiques sur le cancer, Villejuif, France.
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Frayssinet
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Lafarge-Frayssinet
D001647:Bile Acids and Salts / Q000009:adverse effects; D002273:Carcinogens / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000009:adverse effects; D008113:Liver Neoplasms / Q000139:chemically induced*; D010634:Phenobarbital / Q000009:adverse effects
D001647:Bile Acids and Salts; D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D010634:Phenobarbital
Le concept de promotion tumorale appliqué au tissu hépatique.