Thyrotropin-releasing hormone (TRH) counteracts neuronal damage induced by a substance P antagonist.
Intrathecal administration of the substance P antagonist Spantide caused marked necrotic changes of the gray matter of the spinal cord extending several segments from the injection site. Intravenous treatment with several doses of thyrotropin releasing hormone before and after Spantide injection completely prevented the necrotic lesion.
Freedman
J
J
Hökfelt
T
T
Jonsson
G
G
Post
C
C
D000818:Animals; D007278:Injections, Spinal; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects*; D013118:Spinal Cord Diseases / Q000139:chemically induced; D013373:Substance P / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013373:Substance P; D013973:Thyrotropin-Releasing Hormone; C042867:spantide