Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays.
The extent of mitotic delay and chromosome aberration induction by X-rays and bleomycin has been compared in normal human foetal fibroblasts at doses giving approximately equal levels of cell killing, assayed as colony-forming ability. Bleomycin induced much less G2 delay and chromosome damage than X-rays. We conclude that the major mechanism of cell killing by bleomycin does not involve chromosome damage but the cells pass through a number of division cycles before dying and a common DNA lesion is involved in G2 delay and chromosome damage.
Scott
D
D
Zampetti-Bosseler
F
F
D001761:Bleomycin / Q000633:toxicity*; D002453:Cell Cycle / Q000187:drug effects* / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D005111:Extrachromosomal Inheritance; D006801:Humans; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D014965:X-Rays
D001761:Bleomycin