Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins.
Antigenic relatedness between the virion-associated proteins of caprine arthritis-encephalitis, visna and progressive pneumonia viruses was examined. Antigenic cross-reactivity was assessed by immunoprecipitation of disrupted, radiolabelled virus with goat, sheep and rabbit antisera, followed by resolution of the immunoprecipitation products by SDS-polyacrylamide gel electrophoresis. The results indicate that antigenic cross-reactivity between the caprine and ovine virus isolates involves all of the major virion-associated proteins and glycoproteins. The common antigenic determinants exhibited by virion structural proteins are immunogenic in goats, sheep and rabbits.
Gogolewski
R P
RP
Adams
D S
DS
McGuire
T C
TC
Banks
K L
KL
Cheevers
W P
WP
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D001170:Arthritis, Infectious / Q000382:microbiology / Q000662:veterinary; D011232:Chemical Precipitation; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D004660:Encephalitis / Q000382:microbiology / Q000662:veterinary; D000939:Epitopes / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006041:Goats / Q000276:immunology / Q000382:microbiology*; D007120:Immunochemistry; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*; D014771:Virion / Q000276:immunology; D014790:Visna-maedi virus / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D006023:Glycoproteins; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D014764:Viral Proteins