Influence of substance P on nociception and stress.
In 1980 Oehme and co-workers [11] reported that Substance P (SP) has a dual effect on nociception, which is related to the pain threshold before SP administration. Our recent results showed that the N-terminal part of the SP sequence may be important to the hyperalgesic action, and the C-terminal part to the analgesic action of this peptide. The hyperalgesic effect of SP (and N-terminal fragments of SP) seems to be related to the "anti-stress" effect which was first demonstrated by Hecht and co-workers [5] and Oehme and co-workers [12]. Interaction of SP with opioid peptides could be the common reason of both the "anti-stress" effect and the hyperalgesic activity of SP.
Oehme
P
P
Hilse
H
H
Görne
R C
RC
Hecht
K
K
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D007274:Injections, Intraperitoneal; D051379:Mice; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D012684:Sensory Thresholds / Q000187:drug effects; D013312:Stress, Physiological / Q000188:drug therapy / Q000503:physiopathology*; D013329:Structure-Activity Relationship; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D000700:Analgesics; D013373:Substance P