Contact phase of coagulation in diabetes mellitus after aspirin administration.
The purpose of our study was to investigate the connection between platelets and the contact phase of coagulation. In 17 patients affected by diabetes mellitus we studied the behaviour of prekallikrein, factor XII and factor XI before and after aspirin administration. To evaluate the activity of aspirin we measured platelet production of thromboxane B2 using a radioimmunoassay. In our diabetic patients a hypercoagulable state was confirmed: PK, factor XII and XI levels were significantly higher as compared with normal controls. After aspirin administration a significant decrease of PK levels was found. After 7 days of aspirin administration and 7 days after stopping aspirin a modest but not significant improvement of factor XII and factor XI was observed. In conclusion, we believe that the contact phase of coagulation is another index of the hypercoagulable state in diabetes mellitus. In addition, the decrease of PK obtained by aspirin administration could support the possible connection between the contact phase of coagulation and platelets.
Patrassi
G M
GM
Martinelli
S
S
Picchinenna
A
A
Girolami
A
A
D001241:Aspirin / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005172:Factor XI / Q000032:analysis; D005174:Factor XII / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D005174:Factor XII; D005172:Factor XI; D011288:Prekallikrein; D001241:Aspirin