[Application of the Weibull function to the study of in vivo/in vitro correlation].
After transformation of concentration-time curves by integration, the Weibull function is calculated, producing an equation for a derived function representing the plasma (or salivary) kinetics. This model can be employed in the analysis of in vivo/in vitro correlations, since cumulated dissolution percentages can be directly expressed as Weibull functions. A method was developed for prediction of salivary kinetics from in vitro dissolution data and the in vivo kinetics of a solution of the drug. This method was applied to results obtained for slow release formulations of acetaminophen and theophylline administered by the oral route.
Rodriguez
F
F
Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Université Paul Sabatier, Toulouse.
Arama
E
E
Magbi
M
M
Paulin
T
T
Rouffiac
R
R
D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D012463:Saliva / Q000378:metabolism; D013223:Statistics as Topic
Application de la fonction de Weibull à l'étude des corrélations in vivo/in vitro.