Stimulating effect of duodenal alkalinization on pancreatic exocrine secretion in rats.
Intraduodenal instillations of 1.0 M NaHCO3, 0.1 M Na2CO3, and 0.1 M NaOH in anesthetized rats stimulated significantly the pancreatic exocrine secretion showing 3.8-, 7.1-, and 19.0-fold increase of the pancreatic juice flow, respectively. Protein concentration and amylase activity in pancreatic juice increased after injecting NaOH, but decreased after injecting Na2CO3.
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D000468:Alkalies / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D002254:Carbonates / Q000494:pharmacology*; D004386:Duodenum / Q000502:physiology*; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*; D017693:Sodium Bicarbonate; D012972:Sodium Hydroxide / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000468:Alkalies; D001639:Bicarbonates; D002254:Carbonates; D011506:Proteins; C005686:sodium carbonate; D012972:Sodium Hydroxide; D017693:Sodium Bicarbonate; D012964:Sodium; D000681:Amylases; D006851:Hydrochloric Acid