Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Deficits of axonal transport in short-term experimental diabetes may be a consequence of increased sorbitol pathway flux and may contribute to the development of degenerative neuropathies. Therefore, we studied the effect of the aldose reductase inhibitor sorbinil on the axonal transport of choline acetyltransferase (ChAT) in the cholinergic neurons of the sciatic nerve of rats with short-term streptozotocin diabetes. In addition, to examine the extent of axonal transport deficits, we studied the axonal transport of choline containing lipids in sensory neurons of the sciatic nerve of similarly diabetic rats and the effects of sorbinil thereon. In experimentally diabetic animals, sorbinil both prevented and reversed deficits of the axonal transport of ChAT and prevented a deficit in the axonal transport of choline containing lipids.
G B
GB
Willars
D R
DR
Tomlinson
J P
JP
Robinson
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000517:prevention & control; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D048289:Imidazolidines; D007294:Inositol / Q000032:analysis; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000032:analysis; D013012:Sorbitol / Q000032:analysis
D001786:Blood Glucose; D007093:Imidazoles; D048289:Imidazolidines; D010743:Phospholipids; D007294:Inositol; D013012:Sorbitol; D002795:Choline O-Acetyltransferase; C026411:sorbinil