Prevention of thrombosis in arteries: novel approaches.
A number of drugs such as unfractionated heparin, oral anticoagulants, and agents inhibiting platelet function, are being used in the prevention of arterial thrombosis; novel antithrombotic substances are in the making. Among the latter are low-mol-wt heparin and semisynthetic heparin analogs, unfractionated and low-mol-wt heparin covalently complexed or not with anti-thrombin III, pyridoxal phosphate, scavengers of free radicals, synthetic inhibitors of serine proteases, and stimulators of endogenous fibrinolysis.
Verstraete
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D000925:Anticoagulants / Q000494:pharmacology; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001798:Blood Proteins / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D005609:Free Radicals; D006493:Heparin / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors; D011517:Prothrombin Time; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D012697:Serine Endopeptidases; D013927:Thrombosis / Q000517:prevention & control*; D014810:Vitamin E / Q000494:pharmacology; D014812:Vitamin K / Q000494:pharmacology
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D001798:Blood Proteins; D005609:Free Radicals; D008054:Lipid Peroxides; D010982:Platelet-Derived Growth Factor; D011480:Protease Inhibitors; D014812:Vitamin K; D014810:Vitamin E; D011732:Pyridoxal Phosphate; D006493:Heparin; D012697:Serine Endopeptidases