Beneficial effect on intestinal anastomoses of S-2441, a synthetic kallikrein-kinin antagonist. Experimental studies in the rat.
The effects of two protease inhibitors on breaking strength of an intestinal anastomosis were studied. The inhibitors tested were aprotinin and S-2441, a synthetic triple-peptide kallikrein-kinin antagonist. Rats were subjected to an end-to-end anastomosis in the small intestine. The breaking strength, or suture-holding capacity, was measured immediately after suture and after 24 hours. The loss of mechanical strength found in untreated rats was substantially, but not fully, prevented by S-2441. Aprotinin in the dose given was not effective.
Högström
H
H
Haglund
U
U
Zederfeldt
B
B
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001696:Biomechanical Phenomena; D007082:Ileum / Q000187:drug effects / Q000601:surgery*; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011126:Polypropylenes; D051381:Rats; D011919:Rats, Inbred Strains; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D013536:Suture Techniques; D013537:Sutures
D009842:Oligopeptides; D011126:Polypropylenes; C041399:prolyl-phenylalanyl-N-heptylargininamide; D007611:Aprotinin; D007610:Kallikreins