[Occurrence of subdural hematoma closely associated with danazol administration in a patient with refractory ITP].
We reported a 34-year-old female patient with refractory idiopathic thrombocytopenic purpura (ITP) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level. It is strongly suggested that danazol should be very carefully administered in ITP patients with serious bleeding tendency.
Shinmyozu
K
K
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima, Japan.
Okadome
T
T
Maruyama
Y
Y
Maruyama
I
I
Osame
M
M
Tara
M
M
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D003613:Danazol / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006408:Hematoma, Subdural / Q000139:chemically induced*; D006801:Humans; D011245:Pregnadienes / Q000009:adverse effects*; D011486:Protein C / Q000032:analysis; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000188:drug therapy*
D011245:Pregnadienes; D011486:Protein C; D000990:Antithrombin III; D005340:Fibrinogen; D003613:Danazol