Effect of Iloprost (ZK 36 374), a novel prostacyclin analogue, on ADP-induced platelet aggregation.
The effect of Iloprost (ZK 36 374), a chemically stable carboprostacyclin derivative, on ADP-induced platelet aggregation was investigated using platelet-rich plasma obtained from healthy male volunteers. It was shown that Iloprost in a dose-dependent fashion powerfully inhibits both the primary and secondary wave of ADP-induced platelet aggregation. Similarly, Iloprost immediately and most effectively disaggregates preformed platelet aggregates.
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H
Wadenvik
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J
Kutti
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D016285:Iloprost; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*
D000244:Adenosine Diphosphate; D011464:Epoprostenol; D016285:Iloprost