New aspects in the pathogenesis of infectious and tumor anaemia.
From new evidence of increased adhesion of immune complexes in the plasma protein film of erythrocytes, the pathogenesis of tumor anaemia and anaemia in chronic infections is suggested to be a mechanism of the early sequestration of the erythrocytes by erythrophagocytosis following their coating with immune complexes and denaturated immunoglobulins.
Frick
G
G
Linke
A
A
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007239:Infections / Q000276:immunology*; D008855:Microscopy, Electron, Scanning; D009369:Neoplasms / Q000276:immunology*; D010587:Phagocytosis
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G