Complete remission of brain metastases of ovarian cancer following high-dose carboplatin: a case report and pharmacokinetic study.
Brain metastases developed in a 40-year-old woman with relapsed ovarian cancer 2 years after cisplatin-based combination chemotherapy. After a single dose of 800 mg/m2 carboplatin, complete remission of the brain metastases occurred. A pharmacokinetic study during the second course revealed low levels of carboplatin in the cerebrospinal fluid.
Clinical Research Unit, Netherlands Cancer Institute, Amsterdam.
L T
LT
Vlasveld
J H
JH
Beynen
W
W
Boogerd
W W
WW
Ten Bokkel Huinink
S
S
Rodenhuis
D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D016190:Carboplatin; D003536:Cystadenocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D010051:Ovarian Neoplasms / Q000473:pathology*
D009944:Organoplatinum Compounds; D016190:Carboplatin