Effects of naftidrofuryl on the indocyanine green clearance and cardiovascular function of rats with liver cirrhosis.
The influence of intrahepatically infused naftidrofuryl (Dusodril) on indocyanine green (ICG) clearance was measured in healthy rats and rats with liver cirrhosis. In control rats naftidrofuryl reduced the ICG clearance from 0.043 to 0.029 mumol/min/g liver. Plasma half-life of ICG was prolonged significantly from 3.07 to 4.25 min. This was probably due to a depression of the cardiovascular function (blood pressure, heart-rate). In cirrhotic rats, the removal rate of ICG (0.050 mumol/min/g liver) was significantly lower and its half-life (7.61 min) longer than in normal rats. Probably the extraction rate for ICG was so low that naftidrofuryl did not further impair the reduced ICG clearance and half-life inspite of reduced diastolic blood pressure and heart rate.
Institut für Pharmakologie und Toxikologie, Lehrstuhl für Toxikologie und Pharmakologie, Universität Erlangen, Nürnberg, Fed. Rep. of Germany.
U
U
Steinmann
R
R
Braun
H
H
Sippel
C J
CJ
Estler
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007208:Indocyanine Green; D007700:Kinetics; D008099:Liver / Q000187:drug effects*; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D009257:Nafronyl / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005663:Furans; D009257:Nafronyl; D007208:Indocyanine Green