[Androgen status in rabbits after long-term administration of non-steroid androgen antagonist niftolid].
Niphtholid (25 mg/kg/dl for 60 days) significantly increases the LH and testosterone blood levels but has no marked effect on ++androstenedione and testosterone-estradiol-binding globulin levels in Chinchilla++ mature rabbits. The concentration of latter was elevated against a background of low testosterone and androstenedione and high LH levels in the castrated rabbits. The obtained results show that niphtholid exerts a continuous stimulating and pronounced effect on the rabbit pituitary-gonadal axis and simultaneously prevents the manifestation of suppressing androgen effect on testosterone-estradiol-binding globulin contents in the organism.
Varga
S V
SV
Sinitsyn
P V
PV
Tarasenko
L V
LV
D000284:Administration, Oral; D000726:Androgen Antagonists / Q000008:administration & dosage*; D000735:Androstenedione / Q000097:blood*; D000813:Anilides / Q000008:administration & dosage*; D000818:Animals; D005485:Flutamide / Q000008:administration & dosage*; D008297:Male; D011817:Rabbits; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000096:biosynthesis*; D013268:Stimulation, Chemical; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D000726:Androgen Antagonists; D000813:Anilides; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D000735:Androstenedione; D005485:Flutamide
Androgennyĭ status u krolikov v usloviiakh prodolzhitel'nogo vvedeniia nesteroidnogo antiandrogena niftolida.