Relation between inhibition of calmodulin and mediator release from rat mast cells.
Cationic drugs that interact with calmodulin such as chlorpromazine, trifluoperazine, W-7 and lidocaine caused dose-dependent release of mediator from rat mast cells. A significant correlation was observed between the effects of test drugs with different structure in causing mediator release and calmodulin inhibition.
Ohishi
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K
Suzuki
T
T
Uchida
M K
MK
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002746:Chlorpromazine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology; D008081:Liposomes / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D008081:Liposomes; D013449:Sulfonamides; D014268:Trifluoperazine; D012701:Serotonin; C017967:W 7; C034700:N-(6-aminohexyl)-1-naphthalenesulfonamide; D008012:Lidocaine; D002118:Calcium; D002746:Chlorpromazine