Urinary phenylacetic acid in panic disorder with and without depression.
Phenylacetic acid (PAA) excretion was measured in 39 patients who met criteria for panic disorder; 9 of these also had major depression, and 30 did not. Patients with panic and depression excreted 66 +/- 23 mg/day of PAA, an amount significantly lower than in normal controls; patients with panic disorder but without depression excreted 104 +/- 23 mg/day of PAA (not significantly lower than controls). The results support previous studies indicating that PAA excretion is a marker for depressive disorder.
Sabelli
H C
HC
Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois.
Javaid
J I
JI
Fawcett
J
J
Kravitz
H M
HM
Wynn
P
P
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000652:urine*; D003866:Depressive Disorder / Q000175:diagnosis / Q000652:urine*; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000502:physiology*; D010648:Phenylacetates / Q000652:urine*
D010648:Phenylacetates; C025136:phenylacetic acid