Stress-induced synthesis of melatonin: possible involvement of the endogenous monoamine oxidase inhibitor (tribulin).
Cold-restrained stress increased rat pineal melatonin and N-acetylserotonin content. This effect was partially prevented by lorazepam. Serotonergic turnover (ratio of 5-hydroxyindole acetic acid to serotonin) was significantly decreased in stressed but not in stressed rats pretreated with lorazepam, suggesting stress-induced inhibition of monoamine oxidase (MAO). Literature data indicate that the same type of stress increases the production of the endogenous MAO inhibitor. The implication of stress-induced MAO inhibition on melatonin synthesis in anxiety and drug withdrawal is discussed.
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McIntyre
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D000818:Animals; D003080:Cold Temperature; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D006917:Hydroxytryptophol / Q000097:blood; D007510:Isatin; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D012701:Serotonin / Q000031:analogs & derivatives / Q000097:blood; D013312:Stress, Physiological / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood
D008996:Monoamine Oxidase Inhibitors; D006917:Hydroxytryptophol; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007510:Isatin; C039776:tribulin; D014364:Tryptophan; D008550:Melatonin; D008140:Lorazepam; C006389:N-acetylserotonin