The influence of isoprinosine (ISO) on some cell immunity parameters in mice infected with influenza viruses and in mixed viral-bacterial infections. I. The release of the migration inhibiting factor from spleen leukocytes.
The influence of ISO, the antiviral drug of immunomodulating activity, on the course of experimental influenza infections and mixed, viral-bacterial infections was studied. Spleen leukocytes migration inhibition test, performed in vitro in the presence of specific antigens stimulating influence of the drug administered to the infected animals was observed.
Białek
J
J
Denys
A
A
Kowalska
M
M
Szydłowska
T
T
D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology; D007111:Immunity, Cellular / Q000187:drug effects; D009980:Influenza A virus; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis*; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000166:cytology*; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D013997:Time Factors
D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D007288:Inosine; D007542:Inosine Pranobex