[Evaluation of thrombus scintigraphy using 67Ga-deferoxamine-dialdehydestarch-fibrinogen in patients with internal A-V shunt].
We evaluated the diagnosis of thrombus and the effect of antithrombic therapy by using 67Ga-DFO-DAS-Fibrinogen (67Ga-Fbg.) scintigraphy in vivo. The 11 patients with chronic renal failure had the operation of the internal A-V shunt. The two groups were divided the group I (the patients were injected 67Ga-Fbg. within 5 days after the operation of A-V shunt) from the group II (the patients were injected 67Ga-Fbg. from 7 months to 6 years after A-V shunt). We examined 72 h after the injection of 67Ga-Fbg. in all patients. In group I, the scintigraphy showed the deposition of 67Ga-Fbg. in all 5 patients, but 3 patients were given dipyridamole (75-300 mg). The scintigraphy examined 3 weeks after A-V shunt were negative in 2 patients in group I. In group II, the scintigraphy showed the deposition of 67Ga-Fbg. in the two of 6 patients. Within 5 day after A-V shunt, we observed there was the tendency of the thrombus formation. The scintigraphy of 67Ga-Fbg. was useful for the detection of thrombus in vivo.
First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
J
J
Yamazaki
T
T
Uchi
Y
Y
Kawamura
M
M
Iida
Y
Y
Hachiya
K
K
Matsuzaki
T
T
Morishita
T
T
Obara
K
K
Hirata
M
M
Noguchi
D000293:Adolescent; D000328:Adult; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D003676:Deferoxamine; D005260:Female; D005340:Fibrinogen; D005710:Gallium Radioisotopes; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013213:Starch / Q000031:analogs & derivatives*; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology
D005710:Gallium Radioisotopes; C056464:gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate; D005340:Fibrinogen; D013213:Starch; D003676:Deferoxamine