Polyglutamation of methotrexate. Is methotrexate a prodrug?
Chabner
B A
BA
Allegra
C J
CJ
Curt
G A
GA
Clendeninn
N J
NJ
Baram
J
J
Koizumi
S
S
Drake
J C
JC
Jolivet
J
J
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism; D003692:Delayed-Action Preparations; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007700:Kinetics; D008727:Methotrexate / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D010453:Peptide Synthases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors
D003692:Delayed-Action Preparations; D010455:Peptides; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate