[The use of the antipyrine test in assessing liver function in patients with insulin-dependent diabetes mellitus].
The antipyrine test in the authors' modification was used for investigation of liver function in patients with insulin dependent diabetes mellitus. The drug was administered per os a dose of 15 mg per 1 kg of body mass. Its concentration was determined in saliva spectrophotometrically and calculated a period of its half-life [correction of semielimination] (T1/2). In half of 19 patients T1/2 of antipyrine was inhibited 3.2 times, in 4 patients it was decreased 2.1-fold, and in 6 patients it was unchanged. Indices of routine biochemical liver tests were within normal. In patients with inhibited excretion of antipyrine there were signs of disturbed lipid and carbohydrate metabolism. The antipyrine test can be recommended as an auxiliary method for evaluation of the gravity of liver parenchymal lesion in patients with diabetes mellitus.
Khanina
E V
EV
Gorshteĭn
E S
ES
Michurina
S P
SP
D000293:Adolescent; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged
D000983:Antipyrine
Ispol'zovanie antipirinovogo testa pri otsenke funktsional'nogo sostoianiia pecheni u bol'nykh insulinzavisimym sakharnym diabetom.