Mechanisms of glucocorticosteroid action in bronchial asthma.
Although their precise mechanisms of action are undefined, the usefulness of CCS in the treatment of asthma is unquestioned. It is clear that they act at multiple sites. Among the general actions of CCS felt to be applicable to asthma are their ability to facilitate beta-adrenergic responsiveness and to suppress inflammation. More specific actions relevant to asthma are their inhibition of eicosanoid formation (e.g., reduction in leukotriene formation), prevention and reversal of LPR (probably through CCS anti-inflammatory effects), and reduction in mucus secretion. Actions that have not yet been clarified but that may be useful include possible reductions in airway hyperreactivity (or at least the prevention of increases in reactivity superimposed upon overreactive airways) and suppression of basophil (but not mast cell) mediator release.
Kaliner
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D000262:Adenylyl Cyclases / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001491:Basophils / Q000187:drug effects; D001986:Bronchial Spasm / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D004487:Edema / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007249:Inflammation / Q000517:prevention & control; D008214:Lymphocytes / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects; D009093:Mucus / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D001095:Arachidonic Acids; D005938:Glucocorticoids; D011943:Receptors, Adrenergic, beta; D016718:Arachidonic Acid; D007073:Immunoglobulin E; D000242:Cyclic AMP; D000262:Adenylyl Cyclases