The prevention of chemical hepatocarcinogenesis in rats by combining active and passive immunization with alpha-fetoprotein.
The rats were immunized actively with mouse alpha-fetoprotein and passively with a horse antiserum against rat alpha-fetoprotein. The immunized rats fed 3'-methyl-4-dimethylaminoazobenzene containing diet. The development of hepatocellular carcinoma in livers were completely prevented.
Kamata
Y
Y
D002759:Adenoma, Bile Duct / Q000139:chemically induced*; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000032:analysis; D000917:Antibody Formation; D000918:Antibody Specificity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D007114:Immunization; D007116:Immunization, Passive; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008749:Methyldimethylaminoazobenzene; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000008:administration & dosage / Q000032:analysis / Q000276:immunology*
D000906:Antibodies; D000509:alpha-Fetoproteins; D008749:Methyldimethylaminoazobenzene