The effect of Bay K 8644 on contraction mediated by alpha-adrenoceptors in the rat saphenous vein.
The effect of Bay K 8644 on the contractile responses of the rat saphenous vein to KCl, noradrenaline, methoxamine, and B-HT 920 were studied. In all cases, Bay K 8644 potentiated the responses. These results confirmed the suggestion that alpha-adrenoceptor agonists initiated contraction in the rat saphenous vein by opening the potential-operated calcium channels.
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Cheung
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D004357:Drug Synergism; D007473:Ion Channels / Q000502:physiology; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012501:Saphenous Vein / Q000502:physiology
D001381:Azepines; D007473:Ion Channels; D011942:Receptors, Adrenergic, alpha; D011189:Potassium Chloride; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; C024763:talipexole; D008729:Methoxamine; D009543:Nifedipine; D002118:Calcium; D009638:Norepinephrine