Furosemide blocks the apomorphine-elicited Cl-channel activity of rat striatal dopamine receptors functionally reconstituted into bimolecular lipid membrane.
Furosemide blocks the apomorphine-induced step-like conductance increase of the bimolecular lipid membrane pretreated with rat striatal homogenate. Biionic potential measurements also suggest that the reconstituted dopamine receptor is probably linked to a chloride channel.
V
V
Vodyanoy
I
I
Vodyanoy
R B
RB
Murphy
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002712:Chlorides / Q000378:metabolism; D003342:Corpus Striatum / Q000648:ultrastructure*; D018492:Dopamine Antagonists; D005665:Furosemide / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008051:Lipid Bilayers / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*
D002712:Chlorides; D018492:Dopamine Antagonists; D007473:Ion Channels; D008051:Lipid Bilayers; D011954:Receptors, Dopamine; D005665:Furosemide; D001058:Apomorphine