Application of regression analysis in the evaluation of tumor response following the administration of adriamycin either as a solution or via albumin microspheres to the rat.
Regression analysis has been applied to compare the tumor response following the administration of free and microsphere-loaded adriamycin to the rats. A nonmetastasizing sarcoma was induced in male A.S. inbred rats. When the sarcoma was in its fourth passage and 12 days old, four groups of animals received intratumoral injections of 2 or 8 mg/kg of adriamycin as a solution or via albumin microspheres. The animals in each group were monitored over a period of three weeks for changes in body weight and tumor size and their survival, and the results were statistically compared with the data obtained from an untreated group of animals (control). The use of regression analysis in conjunction with partial F-test revealed that the microsphere-delivered drug exhibited a meager but significantly greater response than the free drug. The implications of intratumoral administration of microsphere-loaded drug in the treatment of sarcomas is discussed.
Gupta
P K
PK
Department of Pharmacy, University of Otago, Dunedin, New Zealand.
Hung
C T
CT
Lam
F C
FC
D000418:Albumins; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004337:Drug Carriers; D005069:Evaluation Studies as Topic; D007267:Injections; D008297:Male; D008863:Microspheres; D051381:Rats; D012044:Regression Analysis; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012996:Solutions
D000418:Albumins; D004337:Drug Carriers; D012996:Solutions; D004317:Doxorubicin