Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives.
5-Azacytosine, 1-methyl-5-azacytosine and 5-azacytidine administered to rats with a ligated pylorus block gastric secretion, gastric acidity, the extent of hemorrhage and the number and size of gastric defects. The same drugs also depress the development of experimental acute pancreatitis mediated in rats by interstitial administration of 7.5% natrium cholate into the pancreas in vivo. The drugs affected the amount of abdominal fluid and 6 h after the treatment the pathological changes were significantly decreased.
Cihák
A
A
Pískala
A
A
Korbová
L
L
Cízková
J
J
Kucerová
V
V
D000818:Animals; D001374:Azacitidine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D010195:Pancreatitis / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control*
C046141:N(4)-methyl-5-azacytidine; C039854:5-azacytosine; D003596:Cytosine; D001374:Azacitidine