A consensus amino-acid sequence repeat in Torpedo and mammalian Ca2+-dependent membrane-binding proteins.
A group of calcium-binding proteins which bind to biomembranes has recently been identified in widely different cells and tissues (refs 1-7, reviewed in ref. 8). Three of these proteins (p70, p36 and p32.5) cross-react with antiserum to calelectrin, a Ca2+-binding protein (relative molecular mass 34,000 (34K] from the ray Torpedo marmorata, giving rise to their designation as calelectrin-related proteins. We now report that calelectrin, p36 and p32.5 contain a 17-amino-acid consensus sequence which is conserved and present in multiple copies. We suggest that this sequence may be common to other members of this new group of Ca2+-binding proteins and may underlie their unusual mode of combination with biomembranes.
M J
MJ
Geisow
U
U
Fritsche
J M
JM
Hexham
B
B
Dash
T
T
Johnson
D000595:Amino Acid Sequence; D000818:Animals; D017304:Annexin A5; D017302:Annexins; D000911:Antibodies, Monoclonal / Q000276:immunology; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002148:Calmodulin-Binding Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D000939:Epitopes; D007425:Intracellular Membranes / Q000378:metabolism*; D015688:Oncogene Protein pp60(v-src); D010446:Peptide Fragments / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src); D012191:Retroviridae Proteins / Q000378:metabolism
D017304:Annexin A5; D017302:Annexins; D000911:Antibodies, Monoclonal; D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D000939:Epitopes; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D012191:Retroviridae Proteins; D015688:Oncogene Protein pp60(v-src); D016392:Proto-Oncogene Proteins pp60(c-src)