A new canine model to evaluate the biological effects of implant materials and surface coatings on intramedullary bone ingrowth.
A new animal model for examining the intramedullary bone response to various implant materials and surfaces is presented, utilizing an implantable chamber with multiple bone ingrowth channels placed through a cortical defect in the lateral aspect of the distal femur. Twelve adult mongrel dogs received bilateral implants containing channels lined by smooth-surfaced coupons of titanium, titanium alloy, sputter-hydroxyapatite-coated titanium alloy, and UHMW polyethylene. A pattern was detected for all test groups of early initial bone ingrowth by two weeks, which became maximal at six to twelve weeks, followed by remodelling to a more mature lamellar bone and later resorption by 24 weeks, with fibrous tissue interfaces covering the smooth test coupons of all groups at all times. Significantly increased bone ingrowth in the sputter-HA coated group was found only at six weeks.
Department of Bioengineering, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.
J M
JM
Spivak
N C
NC
Blumenthal
J L
JL
Ricci
H
H
Alexander
D000818:Animals; D001672:Biocompatible Materials; D001846:Bone Development / Q000502:physiology; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D008422:Materials Testing; D008970:Molecular Weight; D011095:Polyethylenes; D019736:Prostheses and Implants; D011859:Radiography; D013499:Surface Properties; D014025:Titanium
D001672:Biocompatible Materials; D011095:Polyethylenes; D014025:Titanium