Relationship between smooth muscle and cytoskeleton antibodies in neuroblastoma.
The previously reported high prevalence of smooth muscle antibodies in neuroblastoma has been found to be associated with a similarly elevated prevalence of anti-cytoskeleton antibodies. The most relevant finding is related to anti-microfilaments (anti-actin) and anti-microtubules antibodies, which were detected with highly significantly different prevalences when compared with a disease control group (p less than 0.001 and p less than 0.000001, respectively). The correspondence between smooth muscle antibodies and anti-cytoskeleton antibodies is incomplete, and it is more relevant for anti-microfilaments. It is concluded that antigen specificities of smooth muscle antibodies in neuroblastoma are as complex as documented in other diseases. Possible pathogenetic and clinical implications emerging from these data are discussed.
D
D
Zauli
C
C
Crespi
A F
AF
Mancini
M
M
Zerbini
F B
FB
Bianchi
E
E
Pisi
D000906:Antibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003599:Cytoskeleton / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008870:Microtubules / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology*; D009447:Neuroblastoma / Q000276:immunology*
D000906:Antibodies; D000939:Epitopes