[Interferonogenicity of the bacterial lysates in human and murine cell cultures].
The antibacterial JRS vaccine was found to be capable of inducing interferon production in human peripheral blood leukocytes and mouse bone marrow cells. The vaccine induced no interferon in L-929 cells or human diploid M-19 cells. Interferon appeared in the culture fluid within 4-6 hours after induction and reached the maximum levels in 18-24 hours. One-hour contact of the vaccine with leukocytes was sufficient for interferon induction. The interferon generated in human blood leukocytes was partially stable at pH 2.2; heating at 56 degrees C for 30 min reduced its activity 4-fold; antiserum to alpha-interferon inhibited it.
Zhdanov
L V
LV
Schubert
K
K
Orlova
T G
TG
Mentkevich
L M
LM
D000818:Animals; D001428:Bacterial Vaccines / Q000494:pharmacology; D001433:Bacteriolysis; D001853:Bone Marrow / Q000187:drug effects*; D002478:Cells, Cultured; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis; D007739:L Cells / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D013997:Time Factors
D001428:Bacterial Vaccines; D007369:Interferon Inducers; D007372:Interferons
Interferonogennost' bakterial'nykh lizatov v kul'turakh kletok cheloveka i mysheĭ.