Changes in myocardial oxygen demand and instantaneous ventricular vascular volume during prolonged cross-clamping and reperfusion of the abdominal aorta.
In 47 animals (rats, rabbits) the cardiac side effects of prolonged (3 to 6 hours) abdominal aortic cross-clamping and unclamping (3 to 6 hours) were investigated. The relative instantaneous ventricular vascular volume (IVVV), a factor reflecting myocardial blood supply and the rate pressure product (RPP) representing myocardial oxygen demand were used as parameters. Following cross-clamping the IVVV showed an initial decrease while the myocardial oxygen demand revealed a sudden increase. After unclamping, the myocardial oxygen demand decreased and IVVV improved. Minimal levels of both IVVV and RPP occurred at 6 hours following unclamping. This may be an effect of a myocardial inhibiting substance, released by ischemia and necrosis of the lower extremity.
Wang
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Zhang
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Liu
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Song
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D000818:Animals; D001012:Aorta, Abdominal; D003250:Constriction; D003331:Coronary Vessels / Q000502:physiology; D005260:Female; D007457:Iodine Radioisotopes; D007813:Laparotomy; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D010477:Perfusion; D011312:Pressure; D011817:Rabbits; D051381:Rats
D007457:Iodine Radioisotopes