Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice.
Interferon and interferon inducing agents depress hepatic cytochrome P-450 systems. They also induce hepatic xanthine oxidase activity. It has been suggested that free radicals produced by xanthine oxidase may cause the loss of P-450. High titers of serum interferon are induced by poly IC (poly riboinosinic acid.polyribocytidylic acid) in both C57Bl/6J and C3H/HeJ mice; Newcastle disease virus (NDV) induces a high titer of interferon in C57Bl/6J mice but not in C3H/HeJ mice. The induction of xanthine oxidase activity by NDV in C3H/HeJ mice was less than half that seen in C57Bl/6J mice, thus demonstrating a relationship between the induction of xanthine oxidase, the depression of P-450 and a genetically determined difference in responsiveness of mice to interferon inducers.
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Deloria
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Abbott
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Gooderham
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GJ
Mannering
D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D004790:Enzyme Induction / Q000187:drug effects; D005037:Ethylmorphine-N-Demethylase / Q000037:antagonists & inhibitors; D007372:Interferons / Q000097:blood; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D011070:Poly I-C / Q000494:pharmacology*; D013045:Species Specificity; D014969:Xanthine Oxidase / Q000096:biosynthesis*
D065607:Cytochrome P-450 Enzyme Inhibitors; D007372:Interferons; D014969:Xanthine Oxidase; D005037:Ethylmorphine-N-Demethylase; D011070:Poly I-C