Calcitonin gene-related peptide is a potent inhibitor of substance P degradation.
Calcitonin gene-related peptide (CGRP) was found to potently inhibit a substance P endopeptidase isolated from human CSF. CGRP potentiated substance P irritant actions; a possible mechanism is interaction for a common metabolic step. Somatostatin is another peptide capable of competing with substance P endopeptidase.
Le Greves
P
P
Nyberg
F
F
Terenius
L
L
Hökfelt
T
T
D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000494:pharmacology; D013116:Spinal Cord / Q000378:metabolism; D013373:Substance P / Q000037:antagonists & inhibitors* / Q000134:cerebrospinal fluid / Q000378:metabolism; D014667:Vasopressins / Q000494:pharmacology
D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D014667:Vasopressins; D013373:Substance P; D013004:Somatostatin; C036877:substance P (1-7); D015740:Calcitonin Gene-Related Peptide