Modification of morphine withdrawal: effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1-4) of substance P and its amide.
Withdrawal behavior in morphine-dependent rats precipitated by naloxone was attenuated after pretreatment with the tetrapeptide tuftsin and to some extent by its synthetic derivative [Lys4]-tuftsinyltuftsin. The tetrapeptide fragment (1-4) of Substance P was ineffective in suppressing morphine-withdrawal behavior, whereas its C-amide exerted only weak action. Possible involvement of an immunological mechanism is discussed.
Aronowski
J
J
Wleklik
M
M
Gumulka
S W
SW
Luczak
M
M
Konopinska
D
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*; D013375:Substance Withdrawal Syndrome / Q000276:immunology / Q000503:physiopathology*; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013373:Substance P; D009020:Morphine; C046937:tuftsinyltuftsin, Lys(4)-; D014405:Tuftsin