[Effect of cytoplasmic proliferation stimulating factors and partial hepatectomy on DNA synthesis in the liver of rats subjected to prolonged carbon tetrachloride exposure].
Content of RNA was increased, synthesis of nuclear and mitochondrial DNA was induced in liver tissue of rats, which were poisoned with CCl4, within 6 weeks, after intraperitoneal administration of the preparation obtained from regenerating rat liver tissue and containing thermostable factors stimulating proliferation, as well as the low molecular substances of the cell pool. The most pronounced stimulating effect was observed if the administration of the preparation occurred simultaneously with 30% hepatectomy.
Abakumova
O Iu
OIu
Kotaev
A Iu
AIu
Karagiulian
S R
SR
Gal'perin
E I
EI
Orekhovich
V N
VN
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis*; D004272:DNA, Mitochondrial / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D004272:DNA, Mitochondrial; D006131:Growth Inhibitors; D012313:RNA; D004247:DNA
Vliianie tsitoplazmaticheskikh faktorov, stimuliruiushchikh proliferatsiiu, i chastichnoĭ gepatéktomii na sintez DNK v pecheni krys, podvergnutykh dlitel'nomy deĭstviiu chetyrekhkhloristogo ugleroda.