A comparison of the binding of angiotensin II to human placenta between normal and severe pre-eclamptic pregnancy.
We compared the binding of angiotensin II (A-II) to human placenta between normal and severe pre-eclamptic pregnancy. Our data did not show any statistically significant difference between normal and pre-eclamptic pregnancy in both the equilibrium dissociation constant (Kd) and the total number of placental A-II receptors. Therefore, changes in the binding of A-II to placenta might not be involved in the possible cause of activation of the renin-angiotensin system in the feto-placental unit in severe preeclampsia.
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
O
O
Kurauchi
S
S
Mizutani
S
S
Nomura
M
M
Kasugai
O
O
Narita
Y
Y
Tomoda
D000626:Aminopeptidases / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011945:Receptors, Angiotensin / Q000378:metabolism
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000626:Aminopeptidases