The interaction between gamma-type endorphins and HLA class I antigens.
The clinical response of schizophrenic patients to treatment with gamma-type endorphins was found to be associated with certain HLA class I antigens (Bw22, B15, B13). Moreover, pretreatment of lymphocytes from healthy donors with des-Tyr1-gamma-endorphin (DT gamma E) inhibits the complement-dependent cytotoxicity between alloantisera and those HLA antigens, of which the frequency was increased among schizophrenic patients, who respond well to the gamma-endorphin therapy. Also for the opiate antagonist, naloxon interactions with HLA class I antigens could be demonstrated. Using the inhibition assay with DT gamma E it was possible to detect a subtype of HLA-A2, which, until now, was only defined by cytotoxic T lymphocytes and biochemistry. These data suggest an interaction between the HLA class I antigens and the receptor(s) for DT gamma E and naloxon, which may support the hypothesis that HLA class I antigens play a role in many recognition processes. Their role in immunological recognition would then be only a specialized form of a more general function.
Claas
F H
FH
van Ree
J M
JM
Verhoeven
W M
WM
van der Poel
J J
JJ
Verduyn
W
W
de Wied
D
D
van Rood
J J
JJ
D000937:Antigen-Antibody Reactions; D004723:Endorphins / Q000502:physiology* / Q000627:therapeutic use; D006680:HLA Antigens / Q000276:immunology / Q000502:physiology*; D015789:HLA-A2 Antigen; D006801:Humans; D007518:Isoantibodies; D011957:Receptors, Opioid / Q000502:physiology*; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D018823:gamma-Endorphin
D004723:Endorphins; D006680:HLA Antigens; D015789:HLA-A2 Antigen; D007518:Isoantibodies; D011957:Receptors, Opioid; D018823:gamma-Endorphin