Detection of high-risk groups and individuals for periodontal diseases: laboratory markers based on the microbiological analysis of subgingival plaque.
Periodontal microbiology is reviewed with regard to the potential of certain characteristics to serve as markers of high risk groups or individuals for periodontal diseases. The generally accepted associations between particular organisms and the various periodontal diseases are discussed. The usefulness of various clinical study designs is reviewed. The ecology of the subgingival plaque microflora is discussed and a number of suggestions for future research are made. We have concluded that there is no monospecific aetiology to any of the various periodontal conditions. Nevertheless, we give particular attention to the role of the black-pigmented bacteroides based upon our belief that they, and Bacteroides gingivalis in particular, are fundamental to our understanding of the biology of periodontal diseases in humans and other animals. Consequently, the contribution of its various virulence factors and their potential as markers of disease susceptibility and activity is addressed.
Dental Research Unit, London Hospital Medical College, UK.
M F
MF
Maiden
R J
RJ
Carman
M A
MA
Curtis
I R
IR
Gillett
G S
GS
Griffiths
J A
JA
Sterne
J M
JM
Wilton
N W
NW
Johnson
D018407:Bacterial Physiological Phenomena; D003773:Dental Plaque / Q000382:microbiology*; D004198:Disease Susceptibility; D006801:Humans; D010518:Periodontitis / Q000175:diagnosis* / Q000382:microbiology; D012307:Risk Factors