Hypersensitivity of cultured ataxia-telangiectasia cells to etoposide.
Fibroblasts from patients with ataxia-telangiectasia (A-T) were found to be hypersensitive to killing by the antineoplastic agent etoposide. The A-T fibroblast strains GM5823, GM367, and GM2052 were twofold to threefold more sensitive to killing by etoposide than fibroblasts from normal controls (AG1521, AG1522, and IMR90). A simian virus 40 (SV40)-transformed, immortal human fibroblast line (GM5849) derived from the A-T cell line GM5823 was also studied. GM5849 retained the unusual sensitivity of nontransformed A-T fibroblast lines to x-irradiation, bleomycin, and neocarzinostatin (zinostatin). GM5849 was also more sensitive to etoposide than were SV40-transformed fibroblasts from normal controls. M1, and SV40-transformed fibroblast line derived from a patient with xeroderma pigmentosum, had the same sensitivity to etoposide as SV40-transformed fibroblasts derived from normal controls.
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Henner
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Blazka
D000609:Aminoacridines / Q000494:pharmacology; D000677:Amsacrine; D001260:Ataxia Telangiectasia / Q000473:pathology*; D001761:Bleomycin / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA; D005047:Etoposide / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
D000609:Aminoacridines; D000677:Amsacrine; D001761:Bleomycin; D005047:Etoposide; D004247:DNA; D011034:Podophyllotoxin