Prognostic factors in patients with bladder carcinoma treated with definitive irradiation.
An analysis was performed of 116 patients with bladder carcinoma who completed definitive radiotherapy at a single institution. Patients were analyzed for survival and local control. The overall 5-year survival rate was 34%. A multivariate analysis of survival showed disease stage, hemoglobin level, histologic grade, and total dose to be significant factors in outcome. The local control rates for Stage A, B, C, and D patients were 26%, 36%, 18%, and 0%, respectively. The multivariate analysis revealed disease stage and pretreatment hemoglobin level to be significant predictors of local control. In patients unsuitable for surgery or current combined technique protocols, high-dose irradiation may offer some patients survival and local control. Furthermore, prognostic factors in this study may aid in the stratification necessary for current protocol designs.
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia.
K M
KM
Greven
L J
LJ
Solin
G E
GE
Hanks
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery
D006441:Hemoglobin A