Role of acetylcholine receptor subunits in gating of the channel.
The Torpedo and calf acetylcholine receptors and hybrids composed of subunits from the two species have been produced in Xenopus oocytes by the use of the cloned complementary DNAs. Single-channel current measurements indicate that these receptors form channels of similar conductance but with different gating behaviour.
Sakmann
B
B
Methfessel
C
C
Mishina
M
M
Takahashi
T
T
Takai
T
T
Kurasaki
M
M
Fukuda
K
K
Numa
S
S
D000818:Animals; D002417:Cattle; D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology*; D046911:Macromolecular Substances; D009865:Oocytes; D011978:Receptors, Nicotinic / Q000502:physiology*; D013329:Structure-Activity Relationship; D014101:Torpedo; D014981:Xenopus
D007473:Ion Channels; D046911:Macromolecular Substances; D011978:Receptors, Nicotinic