[Effects of heat treated cells of intestinal lactic acid bacteria in rats fed a deoxycholic acid diet].
Effects of the administration of heat treated cells of intestinal lactic acid bacteria were examined in rats fed a deoxycholic acid (DCA) diet. Male Wistar rats were given a 0.25% DCA diet with or without the heat treated cells of Enterococcus faecalis AD 1001 (EFH-1) or Lactobacillus reuteri AD 0002 (LRH-2) for 4 weeks. Abnormal increases in serum GOT, GPT, UN and lipoproteins were observed in the rats fed the DCA diet. Furthermore, severe lesions in the kidney as well as in the liver were found in these rats. On the contrary, the increases in serum GOT, UN, VLDL and LDL were significantly suppressed, and markedly fewer lesions in the liver and the kidney were observed in the rats fed the DCA diet plus EFH-1 or LRH-2.
Institute for Intestinal and Environmental Microbiology, Advance Co. Ltd., Tokyo, Japan.
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T
Shiina
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Shin
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Ishihara
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Isoda
D000821:Animal Feed; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003840:Deoxycholic Acid / Q000494:pharmacology* / Q000633:toxicity; D004755:Enterobacteriaceae; D006358:Hot Temperature; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D007778:Lactobacillus; D008107:Liver Diseases / Q000473:pathology / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003840:Deoxycholic Acid