Infection of monocyte/macrophages by human T lymphotropic virus type III.
Normal blood-derived monocyte/macrophages were found to be susceptible to infection in vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome. In addition, HTLV-III was recovered from monocyte/macrophages of patients infected with this virus. The above findings raise the possibility that HTLV-III-infected monocyte/macrophages may serve as a vehicle for the dissemination of virus to target organs and as a reservoir for viral persistence, as has been shown for other lentiviruses including visna virus and caprine arthritis encephalitis virus.
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D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D002478:Cells, Cultured; D017977:Deltaretrovirus / Q000254:growth & development* / Q000302:isolation & purification; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D008297:Male; D009000:Monocytes / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D014779:Virus Replication
D012194:RNA-Directed DNA Polymerase