[Seasonal rhythms of the indolamine content in the epiphysis of rats].
Pineal function was studied in Wistar pubertal male rats in summer and winter. It was demonstrated that the pineal weight is inversely related to the day length, increasing in winter and reducing in summer. In winter pineal serotonin is actively metabolized via N-acetylation and subsequent ortho-methylation to form N-acetyl serotonin and melatonin as well as via oxidative deamination followed by ortho-methylation to form 5-hydroxyindolacetic and 5-methoxyindolacetic acids. In summer serotonin metabolism in the pinealocytes changes to direct ortho-methylation of serotonin to form 5-methoxytryptamine. The decreased level of N-acetyltransferase limits the formation of melatonin in the pineal gland in summer.
L A
LA
Bondarenko
D000818:Animals; D001683:Biological Clocks; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D012621:Seasons; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism*; D014363:Tryptamines / Q000378:metabolism
D014363:Tryptamines; D012701:Serotonin; C001736:5-methoxyindoleacetic acid; D006897:Hydroxyindoleacetic Acid; C006389:N-acetylserotonin
Sezonnye ritmy soderzhaniia indolaminov v épifize krys.