Autoimmunity to Thy-1.
Conditions are described for the induction of autoimmunity to Thy-1 and a large panel of monoclonal CBA and AKR autoantibodies has been characterized. These reveal a hitherto unrecognized complexity at the Thy-1 locus and evidence for intragenic control. Epitopes recognized by the autoantibodies differed in species and tissue distribution from alloantigenic determinants but their specificity was confirmed by transfection studies with the cloned Thy-1b gene. The quantitative and qualitative differences in epitope expression between Thy-1a and Thy-1b alleles were inherited as single Mendelian traits and in the absence of recombinants, suggesting translational control.
D B
DB
Thomas
V
V
Giguere
C M
CM
Graham
O L
OL
Oliveira
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D000939:Epitopes; D008040:Genetic Linkage; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000276:immunology; D014018:Tissue Distribution; D014158:Transcription, Genetic; D014162:Transfection
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001323:Autoantibodies; D000939:Epitopes; D018800:Thy-1 Antigens