Recovery study in Mg-deficient rats given an organic source of Mg.
Recovery from Mg deficiency was studied in rats given an organic source of Mg derived from yeast (Saccharomyces cerevisiae) cultured in an Mg gluconate-enriched medium, as the only source of Mg. Magnesium was given either at a rate above the RDA or as a supplement to the regular laboratory diet at the rate of 70 mg Mg/100 g food, of which 40 mg Mg was in the form of MgCO3 and the remaining 30 mg Mg was in the form of the organic product under study. The results showed a good degree of digestive and metabolic utilization of the organic compound, which led to the recovery of normal Mg levels in blood and bone by the end of the 1st week of treatment, and in muscle by the 3rd week of treatment. Muscle Mg content appears to be a good indicator of deficiency. Supplementation above the RDA failed to improve recovery rates in deficient animals.
Escuela de Nutrición, Facultad de Farmacia, Universidad de Granada, España.
P
P
Aranda
M
M
López Frías
M L
ML
Jurado
J
J
Llopis
F J
FJ
Mataix
M
M
Rivero
G
G
Urbano
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000032:analysis; D004032:Diet; D005243:Feces / Q000032:analysis; D005260:Female; D008274:Magnesium / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000188:drug therapy*; D008297:Male; D009132:Muscles / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D015002:Yeast, Dried / Q000627:therapeutic use*
D008274:Magnesium