[Therapeutic response of interferon-beta in malignant melanoma].
Therapeutic responses to systemic administration of interferon-beta (IFN-beta) were studied in 13 patients with malignant melanoma. Of 4 patients with stage IV malignant melanoma receiving systemic IFN-beta therapy alone, none showed any effective result (1MR, 3NC). Treatment with IFN-beta combined with chemotherapy, e.g. DTIC, produced a clinical improvement in 2 of 5 patients with malignant melanoma (1CR, 1PR, 2NC and 1PD). IFN-beta therapy has been performed by intravenous drip infusion concomitantly with chemotherapy before or after surgery, for prevention of metastasis in 4 cases of malignant melanoma (stage Ib, 1 case; stage II, 2 cases; stage III, 1 case). Three patients with stage Ib to II have been progressing favorably without metastasis over the past 3 years and 2 months. Patients receiving indomethacin suppositories for fever associated with IFN-beta therapy were examined for plasma and urinary IFN-beta activity levels. No significant difference was observed whether indomethacin was administered or not. Indomethacin is therefore considered to have no appreciable influence on IFN-beta therapy.
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D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D007263:Infusions, Parenteral; D007370:Interferon Type I / Q000008:administration & dosage* / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
D007370:Interferon Type I; D001761:Bleomycin; D014750:Vincristine; D003606:Dacarbazine; D007213:Indomethacin