Cytogenetic study of a case of childhood erythroleukemia.
We report a case of childhood erythroleukemia diagnosed by French-American-British Cooperative group (FAB) and by cytogenetic analysis of bone marrow cells. The following major chromosome anomalies were detected: hyperdiploidy with a modal number of 49, three markers consisting of translocations between chromosomes 3, 9, 20, and 15, deletion of the long arm of chromosome 16 (q22----qter), and karyotype instability. These changes were compared with others reported in the literature and discussed in terms of their importance for diagnostic confirmation.
Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
M H
MH
Duarte
L G
LG
Tone
L R
LR
Soares
S A
SA
dos Santos
D001853:Bone Marrow / Q000648:ultrastructure; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008297:Male
D005819:Genetic Markers