[Synthesis and anticonvulsant action of propranolol derivatives with a tertiary nitrogen atom].
Tertiary derivatives of the beta-receptorblocker propranolol were synthesized and pharmacologically tested for anticonvulsive activities. The results show that it is possible, to separate the beta-receptor blocking from the anticonvulsive activities by modifying the chemical structure.
VEB Arzneimittelwerk Dresden.
D
D
Lohmann
D
D
Lehmann
E
E
Morgenstern
G
G
Faust
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004597:Electroshock; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000927:Anticonvulsants; D011433:Propranolol; D010433:Pentylenetetrazole
Synthese und antikonvulsive Wirkung von Propranololderivaten mit tertiärem Stickstoffatom.