Interferon production by and radioprotective effect of poly I : C and tilorone in mice exposed to helium alpha irradiation.
Serum interferon production induced by poly I : C and tilorone and their radioprotective effect in mice exposed to He-alpha particles was studied. The results were compared to those observed after exposure of mice to acute 60Co-gamma irradiation. Interferon production induced by poly I : C was depressed by He-alpha irradiation less than that induced by tilorone. Treatment of mice with poly I : C or tilorone before He-alpha irradiation had no effect on the mortality of animals in contrast to the radioprotective activity of these compounds against 60Co-gamma irradiation.
M
M
Tálas
B
B
Fedorenko
L
L
Bátkai
I
I
Stöger
D000512:Alpha Particles; D000818:Animals; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D005720:Gamma Rays; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011070:Poly I-C / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013994:Tilorone / Q000494:pharmacology*
D005449:Fluorenes; D011837:Radiation-Protective Agents; D007372:Interferons; D013994:Tilorone; D011070:Poly I-C