Nude mice are nonpermissive towards the anti-dextran response of congenic cells.
Nude mice bearing allotype Ighb on a BALB/c genetic background (= CB nu/nu) are nonresponders to alpha (1----3)dextran (Dex), in contrast to BALB/c or BALB/c nu/nu. Although CB nu/nu mice accept transplants of congenic BALB/c, or BALB nu/nu lymphocytes, as shown by the expression of donor allotype Igha, they are not permissive for a primary anti-Dex response by the grafted cells. BALB/c or BALB nu/nu cells, however, give a strong anti-Dex response when grafted onto irradiated CB nu/nu or CB 23 (Ighb) euthymic mice. A thymus-independent, radiation-sensitive suppressor cell population is postulated, which specifically hinders the anti-Dex response, and which is exhibited by strains bearing that portion of chromosome 12 which codes for CH allotype Ighb, not containing the germ-line anti-Dex V/D genes. The suppressive action of Ighb lymphocytes could be demonstrated directly in staggered co-transfer experiments.
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D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000917:Antibody Formation; D000918:Antibody Specificity; D003433:Crosses, Genetic; D003911:Dextrans / Q000276:immunology*; D007108:Immune Tolerance; D007116:Immunization, Passive; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude / Q000235:genetics / Q000276:immunology*; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology; D013234:Stem Cells / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D003911:Dextrans; D007143:Immunoglobulin Heavy Chains