Ion transport and oxygen consumption in kidney cortex slices from young and old rats.
The effects of aging on active Na+ extrusion and oxygen consumption associated with it were studied in rat kidney cortex cells. It was found that (a) the active extrusion of Na+ undergoing Na/K exchange and the active extrusion of Na+ with Cl- and water were diminished in old rats (24 months) as compared with young rats (3 months); (b) the oxygen consumption associated with each of the two active mechanisms of Na+ extrusion was also diminished in the old rats; (c) the calculated turnover rate of the Na/K pump was significantly lower for the old rats.
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D000375:Aging; D000818:Animals; D001693:Biological Transport, Active; D002713:Chlorine / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D007672:Kidney Cortex / Q000502:physiology*; D008297:Male; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D002713:Chlorine; D012964:Sodium; D011188:Potassium