The search for cofactors in AIDS, including an analysis of the association of nitrite inhalant abuse and Kaposi's sarcoma.
The identification of cofactors in AIDS is a challenging scientific task. If successful, identifying cofactors could prove valuable in understanding the pathogenesis of HIV infection and AIDS and in the development of strategies to prolong survival and/or prevent complications in HIV-infected individuals. There is sufficient evidence to suggest the existence of a cofactor in KS in AIDS. Nitrite inhalants remain a leading candidate to be the KS cofactor. Until more is known to document or refute this specific virus-drug interaction hypothesis in the pathogenesis of KS in AIDS, clinicians should encourage their patients to avoid use of nitrite inhalants. This article was prepared by a Federal Government employee as part of official duties; therefore, the material is in the public domain and may be reproduced or copied without permission.
Clinical Medicine Branch, National Institute on Drug Abuse, Rockville, Maryland 20857.
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Haverkos
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D015981:Epidemiologic Factors; D006716:Homosexuality; D006801:Humans; D001239:Inhalation; D008297:Male; D009573:Nitrites; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000209:etiology*; D019966:Substance-Related Disorders / Q000150:complications*
D009573:Nitrites