The behaviour of the tissue pO2 in transparent chambers of rats with and without tumour implantations.
Changes of tissue pO2 levels in chronic subcutis wounds with and without heteroplastic tumour spheroid implants in thoraco-lumbal rat skinfolds covered by transparent chambers were followed in crosscut analysis by pO2 surface electrodes as a function of post-operative age using constant normoxic, hypoxic, post-hypoxic breathing conditions and intervals for each measured area. The tissue pO2 showed significantly higher values in the edematous phase of wound healing than in the granulation and differentiation phase. Tumour implantations induced even higher pO2 values in the edematic phase. This difference vanished in later phases. The hypoxic reactivity of non-tumour and tumour tissue improved with post-operative age indicating a sufficient vessel outgrowth.
Streichhan
P
P
Fischer
M
M
Acker
H
H
D000367:Age Factors; D000818:Animals; D005260:Female; D006801:Humans; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012884:Skin Window Technique; D013964:Thyroid Neoplasms / Q000378:metabolism; D014183:Transplantation, Heterologous; D014945:Wound Healing
D010100:Oxygen