The position of the epistatic S locus in the halothane linkage group in pigs.
The linkage of the Phi, Pgd, Po2, S, H and halothane sensitivity loci was followed in a Belgian Landrace family, heterozygous for these systems over 6 generations. Recombination next to the S locus occurred mainly in pigs belonging to this particular family. From this investigation the position of the S locus is proved to be outwith the Phi-Pgd region, next to Phi. Therefore the gene sequence S - Phi - Hal - H - Po2 - Pgd is proposed. Higher recombination rates were observed in the female parental line of the multiheterozygous family when compared to the male parental line. Additional data from animals, unrelated to this strain, confirm the evidence of close linkage of the S system to the nearest marker loci.
Van Zeveren
A
A
Van de Weghe
A
A
Bouquet
Y
Y
Varewyck
H
H
D000483:Alleles; D000510:Alpha-Globulins / Q000235:genetics*; D000818:Animals; D001789:Blood Group Antigens / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D005956:Glucose-6-Phosphate Isomerase / Q000235:genetics*; D006221:Halothane; D006579:Heterozygote; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics*; D012709:Serum Albumin / Q000235:genetics*; D013552:Swine / Q000235:genetics*
D000510:Alpha-Globulins; D001789:Blood Group Antigens; D012709:Serum Albumin; C016073:post albumin; D010734:Phosphogluconate Dehydrogenase; D005956:Glucose-6-Phosphate Isomerase; D006221:Halothane