Tangier disease apolipoprotein A-I compared with normal plasma A-I using monoclonal antibodies.
The molecular defect in Tangier disease is unknown. We have compared the electrophoretic and immunoreactive properties of Tangier disease and normal apolipoprotein A-I using four monoclonal antibodies. We verified that the molecular weight, pI and CNBr-cleaved fragments of Tangier disease and normal apolipoprotein A-I were not different, excluding the possibility that dimers, aggregates or fragments of apolipoprotein A-I could be responsible for its rapid catabolism in this disease.
Weech
P K
PK
Frohlich
J
J
Marcel
Y L
YL
N'Guyen
T D
TD
Milne
R W
RW
D000911:Antibodies, Monoclonal; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood* / Q000276:immunology / Q000302:isolation & purification; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D012016:Reference Values; D013631:Tangier Disease / Q000097:blood*
D000911:Antibodies, Monoclonal; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D000939:Epitopes; D008075:Lipoproteins, HDL