A B cell-suppressive IgG-antiimmunoglobulin antibody induced by alloimmunization.
This study is an extension of our previous report that alloimmunization produces a serum factor that suppresses the lymphocytotoxic antibody response. The experiments presented herein show that: (1) serum and IgG of pretreated rats contain an antibody directed against the constant region of IgG; (2) the anti-IgG has strong anti-Fc-gamma and weak anti-Fab activity; (3) the antibody also reacts with IgM; (4) the antiimmunoglobulin is an autoantibody; and (5) the antiimmunoglobulin suppresses the primary B cell response in vitro.
Department of Transplantation Immunology, University of Heidelberg, Federal Republic of Germany.
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Terness
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Süsal
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Baur
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Guo
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Opelz
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D007114:Immunization; D007140:Immunoglobulin Fab Fragments / Q000378:metabolism; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007074:Immunoglobulin G / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013491:Suppressor Factors, Immunologic / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007518:Isoantibodies; D013491:Suppressor Factors, Immunologic