[Radioprotective action of GHM-10 when administered with dextran sulfate and heparin].
A single administration of dextransulfate (40 mg/kg, 1-3 days before irradiation), or a double injection of heparin (250 units/kg, 24 hr and 15 min before irradiation) potentiated a weak radioprotective effect of gas hypoxic mixture (GHM-10) on animals exposed to absolutely lethal doses.
Zhukova
N A
NA
Palyga
G F
GF
Filippova
S A
SA
Maksimenko
A A
AA
Vacek
A
A
D000818:Animals; D016264:Dextran Sulfate; D003911:Dextrans / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005720:Gamma Rays; D006493:Heparin / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009584:Nitrogen / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage*
D003911:Dextrans; D011837:Radiation-Protective Agents; C041364:nitrox; D006493:Heparin; D016264:Dextran Sulfate; D009584:Nitrogen; D010100:Oxygen
Radiozashchitnoe deĭstvie GGS-10 na fone vvedeniia dekstransul'fata i geparina.