In vivo voltammetry in the suprachiasmatic nucleus of the rat: effects of RU24969, methiothepin and ketanserin.
Differential pulse voltammetry was performed in the suprachiasmatic nucleus (SCN) of anaesthetised rats. Peripheral administration of RU24969 (10 mg/kg) a 5HT1 receptor agonist, decreased the size of the 5HIAA oxidation peak whereas it was increased by the non-selective 5HT receptor antagonist methiothepin (10 mg/kg). The effects of RU24969 were attenuated by methiothepin while the 5HT2 receptor antagonist ketanserin (5 mg/kg i.p.) did not affect the response to RU24969. The results suggest that in vivo 5HT release and metabolism in the SCN is probably under the influence of the 5HT1 receptor.
Martin
K F
KF
Marsden
C A
CA
D000818:Animals; D003988:Dibenzothiepins / Q000494:pharmacology*; D004594:Electrophysiology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007650:Ketanserin; D008297:Male; D008719:Methiothepin / Q000494:pharmacology*; D008839:Microelectrodes; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D013997:Time Factors
D003988:Dibenzothiepins; D010627:Phenethylamines; D010880:Piperidines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008719:Methiothepin; C025254:RU 24926; D007650:Ketanserin