Role of IgE in anaphylactoid reactions during anaesthesia.
As diagnostic methods of detecting drug-specific IgE antibodies become more sophisticated, the evidence implicating specific IgE in anaesthetic allergy has increased. To implicate IgE in reactions, a history resembling anaphylaxis, the demonstration of drug-specific histamine release by intradermal testing and the demonstration of specific antibodies are necessary. Such evidence is seen in 70% of muscle relaxant reactors. Basophil histamine release studies suggest that histamine release is allergen-induced, not direct, and the final evidence necessary is to demonstrate the role of drug-specific antibodies in such histamine release.
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D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology*; D000768:Anesthesia, General / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects; D001491:Basophils / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology*; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects; D012882:Skin Tests
D000777:Anesthetics; D009466:Neuromuscular Blocking Agents; D007073:Immunoglobulin E