Protective effect of topically applied conjugated hexadienes against ultraviolet radiation-induced chronic skin damage in the hairless mouse.
Albino hairless mice (SkH:HR-1) exposed chronically to suberythemal doses of ultraviolet B (UVB) radiation display visible skin wrinkling and tumors. Topical treatment of mice with solutions of conjugated dienes (2,4-hexadien-1-ol and derivatives of it) prior to each UVB radiation exposure reduces significantly the severity of these visible alterations. Chronic suberythemal doses of ultraviolet A radiation induce skin sagging, a distinctly different visible skin alteration. The severity of skin sagging is not reduced by topical application of the conjugated dienes tested here.
Bissett
D L
DL
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239-8707.
Majeti
S
S
Fu
J J
JJ
McBride
J F
JF
Wyder
W E
WE
D000818:Animals; D002908:Chronic Disease; D003877:Dermatitis, Contact / Q000235:genetics; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D000441:Hexanols / Q000494:pharmacology*; D007109:Immunity / Q000235:genetics / Q000528:radiation effects*; D051379:Mice; D008812:Mice, Hairless; D010787:Photosensitivity Disorders / Q000235:genetics / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*
D006183:H-2 Antigens; D000441:Hexanols; C065785:sorbyl alcohol