Comparison between extracellular and tissue fluctuation of dopamine and related metabolites in striatum under hypoxia.
The time course of changes in both extracellular and tissue levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum of halothane-anesthetized rats was compared under hypoxic conditions. A 100-fold increase in the extracellular DA was observed within 20 min of hypoxia, while the tissue DA showed a 1.2-fold increase at the maximum. The inhibition of oxygen-dependent enzymes gives no satisfactory explanation for the acute DA increase, the disruption of DA uptake mechanisms may also participate in this.
Department of Anesthesiology, Toyama Medical and Pharmaceutical University, Japan.
T
T
Masuda
M
M
Yamazaki
Y
Y
Ito
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000502:physiology*; D006719:Homovanillic Acid / Q000378:metabolism; D000860:Hypoxia / Q000503:physiopathology*; D007424:Intracellular Fluid / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid