Treatment of necrobiosis lipoidica with low-dose acetylsalicylic acid. A randomized double-blind trial.
16 patients with clinically and histologically verified necrobiosis lipoidica lesions were treated with either 40 mg acetylsalicylic acid or placebo daily for 24 weeks in a double-blind controlled study. The lesions became statistically significantly larger in both groups in spite of inhibition of the aggregation of the platelets in the acetylsalicylic group.
Beck
H I
HI
Bjerring
P
P
Rasmussen
I
I
Zachariae
H
H
Stenbjerg
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects; D011897:Random Allocation
D001241:Aspirin