The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices.
The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibitory effect of Bay K 8644 on this release was abolished when calcium was excluded from the incubation medium. Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release.
Matsumura
Y
Y
Sasaki
Y
Y
Shinyama
H
H
Morimoto
S
S
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000818:Animals; D002118:Calcium / Q000502:physiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
D007473:Ion Channels; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D012083:Renin; D009543:Nifedipine; D002118:Calcium