Cholinesterase deficiency and the Churg-Strauss syndrome.
We report two patients with the Churg-Strauss syndrome who were found to have decreased cholinesterase activity despite normal phenotypes. Suspicion of abnormal sensitivity to suxamethonium in the first case was raised after prolonged paralysis under anaesthesia. The findings in the second were incidental during the course of intensive care treatment. Both patients received immunosuppressive therapy. Differentiation between the effects of this and the disease process itself cannot be established.
Royal Children's Hospital, Parkville, Victoria, Australia.
B L
BL
Taylor
M
M
Whittaker
V
V
Van Heerden
J
J
Britten
D000328:Adult; D002802:Cholinesterases / Q000172:deficiency* / Q000235:genetics; D015267:Churg-Strauss Syndrome / Q000201:enzymology* / Q000628:therapy; D004342:Drug Hypersensitivity / Q000209:etiology; D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D013390:Succinylcholine / Q000009:adverse effects
D007166:Immunosuppressive Agents; D002802:Cholinesterases; D013390:Succinylcholine