Time-dependent effects of chloroquine on pH of hepatocyte lysosomes.
In vivo administration of chloroquine to rats caused an increase in the pH of hepatocyte lysosomes within 1 hr after administration with a return to baseline pH values by 3 hr; continued administration of chloroquine for up to 12 days was unaccompanied by any further changes in hepatocyte lysosomal pH. We interpret these data as evidence against a major role for an increase in the pH of hepatocyte lysosomes in CAC-induced phospholipidosis.
Gastroenterology Research Unit, Mayo Medical School, Rochester, MN 55905.
P S
PS
Tietz
K
K
Yamazaki
N F
NF
LaRusso
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects*; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002738:Chloroquine