The effects of copper, zinc, mercury, and cadmium on rabbit erythrocytic porphobilinogen synthase in vivo.
The interactions of Zn2+, Hg2+, Cd2+, and Cu2+ with normal and lead-intoxicated rabbit erythrocytic porphobilinogen synthase (PBG-S) were studied in vivo. The results obtained show that each divalent ion has a characteristic effect on the pH-activity relationship of PBG-S. The effects for a given ion were both pH and concentration dependent and were similar to those obtained in vitro. Lead was found to be the most potent effector in vivo.
Ottawa-Carleton Chemistry Institute, Carleton University Campus, Canada.
J P
JP
Farant
D C
DC
Wigfield
D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D003300:Copper / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D006863:Hydrogen-Ion Concentration; D007854:Lead / Q000037:antagonists & inhibitors; D008297:Male; D008628:Mercury / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D000623:Porphobilinogen Synthase / Q000097:blood*; D011817:Rabbits; D015032:Zinc / Q000494:pharmacology
D002413:Cations, Divalent; D008670:Metals; D002104:Cadmium; D007854:Lead; D003300:Copper; D000623:Porphobilinogen Synthase; D008628:Mercury; D015032:Zinc