[Late results of treating thyrotoxicosis with 131I and post-therapeutic hypothyroidism].
A total of 1587 patients with thyrotoxicosis (1387 women and 266 men) were examined over time after 131I therapy. The radioactive drug was given once to 808 patients, two times to 337 patients, 3 times to 198 and 4 times to 82 patients. 669 patients received 74-185 MBq of (131)1,649 patients 222-370 MBq, 128 patients 407-555 MBq and 94 patients 592-740 MBq. The other 47 patients received 131I of higher activity. Post-therapeutic hypothyrosis was revealed in 5.4% of the cases. In half of the patients hypothyrosis developed after a single administration of 131I. In developing hypothyrosis the level of thyroxine and triiodothyronine was lowered in 29% of the patients only, however in 60% of the patients the level of thyroxine in the blood was lowered with the normal concentration of triiodothyronine. In all the patients with post-therapeutic hypothyrosis. i.v. administration of thyroliberin resulted in a significant rise of the thyrotropin level indicating to great importance of this test. A follow up of such patients is necessary as hypothyrosis can develop at different time after treatment of thyrotoxicosis patients with 131I.
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D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000532:radiotherapy*; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D013997:Time Factors
D013956:Antithyroid Agents; D007457:Iodine Radioisotopes
Otdalennye rezul'taty lecheniia tireotoksikoza 131I i postterapevticheskiĭ gipotireoz.