Kaposi's sarcoma: introduction and overview.
KS can be considered to be a paradigm for cancer development. It is readily observable in the skin and has a preneoplastic counterpart. Its development is related to geographic, environmental, genetic, and acquired conditions. Despite a reliably consistent histologic appearance, the tumor displays varied clinical manifestations and natural history that may be attributed to tumor and/or host determinants. Thus, this intriguing neoplasm lends itself to intensive epidemiologic, clinical, and biologic study in an attempt to pin down the etiologic covariants and to develop hypothetical models for further testing.
VA Medical Center, San Francisco, CA 94121.
J L
JL
Ziegler
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000276:immunology