[Structural and functional changes in the mitochondrial apparatus of cortical tubules of the solitary kidney in chronic blockade of cholinergic mediation].
In 15, 30 and 90 days the effect of continuous atropine pharmacological blockade of parasympathetic innervation on morphometrical characteristics of epithelial mitochondria in the cortical segments of the canaliculi has been studied in a single kidney of Wistar rats. The maximal degree of the alternative changes has been determined in the proximal canaliculi. In the distal canaliculi epithelium a compensatory increase of the main quantitative parameters in mitochondria has been registered. The plasticity of the mitochondrial apparatus, specific for the collecting tubules under compensatory hypertrophy, is inhibited under conditions of deparasympathization.
Barinov
E F
EF
Kot
A G
AG
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002799:Cholinergic Fibers / Q000187:drug effects*; D007672:Kidney Cortex / Q000294:innervation / Q000648:ultrastructure*; D007684:Kidney Tubules / Q000648:ultrastructure*; D007686:Kidney Tubules, Distal / Q000294:innervation / Q000648:ultrastructure*; D007687:Kidney Tubules, Proximal / Q000294:innervation / Q000648:ultrastructure*; D008928:Mitochondria / Q000502:physiology / Q000648:ultrastructure*; D009392:Nephrectomy; D009407:Nerve Block; D051381:Rats; D013997:Time Factors
D001285:Atropine
Strukturno-funktsional'nye izmeneniia mitokhondrial'nogo apparata kortikal'nykh kanal'tsev edinstvennoĭ pochki pri khronicheskoĭ blokade kholinergicheskoĭ mediatsii.