Ultrastructural changes in open comedones following treatment of cystic acne with isotretinoin.
The primary change found in cellular material expressed from open comedones of patients who had been treated with isotretinoin was disintegration of desmosomes. Consequently, there was lack of cohesion between cornified cells. A marked decrease in the quantity of sebaceous material and bacteria was also evident within the comedones.
A S
AS
Zelickson
J S
JS
Strauss
J
J
Mottaz
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000382:microbiology; D001419:Bacteria / Q000187:drug effects; D003896:Desmosomes / Q000187:drug effects / Q000648:ultrastructure; D006197:Hair / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D015474:Isotretinoin; D007633:Keratins; D012629:Sebum / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use*
D014212:Tretinoin; D007633:Keratins; D015474:Isotretinoin