[Enhancement of absorption of tetramethylpyrazine by synthetic borneol].
Sprague-Dawley rats were given ig tetramethylpyrazine phosphate (TMP) 5 mg/kg with or without previous borneol 5 mg/kg. The plasma TMP concentrations were analysed by GC method, and the data were treated by NONLIN program. The Cmax were 931 and 562 ng/ml, respectively, (P less than 0.01); while the AUC were 68,849 and 37,174, respectively, (P less than 0.05). It is suggested that the borneol enhances the absorption of the TMP but not in elimination.
Division of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou, China.
T F
TF
Chen
S G
SG
Lin
L X
LX
Chen
G F
GF
Jiang
Z Y
ZY
Liang
M
M
Yang
Y Z
YZ
Qian
Y A
YA
Xie
D000042:Absorption; D000818:Animals; D001892:Camphanes / Q000494:pharmacology; D002164:Camphor / Q000494:pharmacology*; D002849:Chromatography, Gas; D011719:Pyrazines / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000493:pharmacokinetics*
D001892:Camphanes; D011719:Pyrazines; D014665:Vasodilator Agents; D002164:Camphor; C022871:isoborneol; C017953:tetramethylpyrazine