[Genotoxic effect of cigarette smoke condensate on human diploid cell 2BS strain].
A higher sister chromatid exchange (SCE) frequency (17.0/cell) was observed in 2BS cells treated with cigarette smoke condensate (CSC) at 100 micrograms/ml, as compared with 6.9/cell of the background (P less than 0.01). Chromosomal aberration was significantly increased from 4% to 36% in cells treated with 10 micrograms/ml CSC (P less than 0.001). Micronuclei rate varied with CSC from 4 to 26%. There was a dose-effect response between SCE frequency, chromosomal aberration, micronuclei rate and the dose of CSC. The cell-cycle of 2BS cells was markedly delayed by CSC.
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
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Gu
D002453:Cell Cycle; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005333:Fetus; D005347:Fibroblasts; D006801:Humans; D008168:Lung / Q000166:cytology*; D015162:Micronucleus Tests; D010947:Plants, Toxic; D012854:Sister Chromatid Exchange; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana
D012906:Smoke