[Assessment of the activity of tumor necrosis factor in normal state and in ovarian tumors].
The cytotoxic activity of tumor necrosis factor of healthy individuals and patients with cystadenoma and adenocarcinoma of ovaries was investigated. Tumor necrosis factor (TNF) spontaneous activities of healthy donors and patients with cystadenoma of ovaries was the same. The level of TNF spontaneous activity of patients with adenocarcinoma was increased. LPS-induced TNF cytotoxicity in patients with cystadenoma was decreased. Mononuclear cells of patients with adenocarcinoma did not respond to LPS stimulation by increased TNF production.
L V
LV
Koval'chuk
A S
AS
Pavliuk
N Ia
NIa
Aksenova
N V
NV
Iakovleva
S V
SV
Nalbandian
T Iu
TIu
Ul'ianova
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D003537:Cystadenoma / Q000175:diagnosis* / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D007213:Indomethacin
Otsenka aktivnosti faktora nekroza opukholi v norme i pri opukholiakh iaichnikov.