[Drug preparations of immobilized enzymes with enhanced affinity for the site of action].
Several approaches to development of systems for directed transport of drugs are illustrated by an example of thrombolytic therapy. Preparation and properties of enzyme derivatives with increased tropism to the thrombus material due to modification of enzymes by fibrinogen or specific antibodies are discussed. The data on directed transport of drugs under the action of the magnetic field and on the selective action of drugs on culture cells are also presented.
V P
VP
Torchilin
A V
AV
Maksimenko
E G
EG
Tishchenko
M I
MI
Papisov
V N
VN
Smirnov
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000915:Antibody Affinity; D002918:Chymotrypsin / Q000276:immunology / Q000627:therapeutic use; D003911:Dextrans; D004353:Drug Evaluation, Preclinical; D004800:Enzymes, Immobilized / Q000008:administration & dosage*; D005337:Fibrin / Q000276:immunology; D005340:Fibrinogen / Q000008:administration & dosage; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008280:Magnetics; D013927:Thrombosis / Q000188:drug therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D003911:Dextrans; D004800:Enzymes, Immobilized; D005343:Fibrinolytic Agents; D005337:Fibrin; D005340:Fibrinogen; C025614:sephadex; D002918:Chymotrypsin; D014568:Urokinase-Type Plasminogen Activator
Lekarstvennye preparaty immobilizovannykh fermentov s povyshennym srodstvom k mestu deĭstviia.