[Retinoblastoma gene analysis in a patient with osteosarcoma following previous bilateral retinoblastoma].
In a native osteosarcoma specimen of a patient cured of a bilateral retinoblastoma eight years before we found a homozygous deletion of a 7.5 kb Hind III-fragment within the retinoblastoma gene and a hemizygous deletion of the same fragment in its constitutional cells. In a native osteosarcoma tissue of a lung metastasis of a patient with sporadic osteosarcoma the Rb-gene-analysis did not reveal any deletion within the gene. This might be due to the fact that the used c-DNA-probe did not detect point mutations. Nevertheless, the possibility of additional or alternative transforming events should be kept in mind.
Abteilung für pädiatrische Hämatologie und Onkologie, Universität Hamburg.
H
H
Kabisch
R B
RB
Scholz
B
B
Weber
S
S
Heinsohn
C
C
Budde-Steffen
G
G
Landbeck
D001932:Brain Neoplasms / Q000556:secondary; D002648:Child; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D003131:Combined Modality Therapy; D005134:Eye Neoplasms / Q000235:genetics* / Q000628:therapy; D005260:Female; D005266:Femoral Neoplasms / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008649:Mesonephroma / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000628:therapy; D012516:Osteosarcoma / Q000235:genetics* / Q000556:secondary / Q000628:therapy; D010051:Ovarian Neoplasms / Q000235:genetics; D012175:Retinoblastoma / Q000235:genetics* / Q000628:therapy
Retinoblastom-Gen-Befunde bei einem Patienten mit Osteosarkom nach vorausgegangenem beidseitigen Retinoblastom.