Monoamine interactions in narcolepsy and hypersomnia: a preliminary report.
Principal component analysis was performed on data obtained for the concentrations of 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylethylene glycol, homovanillic acid, and 5-hydroxyindoleacetic acid in lumbar cerebrospinal fluid from a group of normal volunteers (n = 40), hypersomniac patients (n = 13), and narcoleptic patients (n = 8). All four compounds were shown to be highly intercorrelated in the normal volunteers. In the hypersomniac patients, 3-methoxy-4-hydroxyphenylethylene glycol did not appear to be correlated with the other three compounds. In the narcoleptic patients, homovanillic acid and 3,4-dihydroxyphenylacetic acid appeared not to be correlated with the other two metabolites. The results provide tentative support for a neurochemical distinction between narcolepsy and hypersomnia and suggest that attention should be given to a possible malfunction of the dopamine system in narcolepsy and norepinephrine in hypersomnia.
K F
KF
Faull
S
S
Thiemann
R J
RJ
King
C
C
Guilleminault
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D001921:Brain / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D009290:Narcolepsy / Q000134:cerebrospinal fluid*; D009638:Norepinephrine / Q000502:physiology; D009435:Synaptic Transmission
D001679:Biogenic Amines; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid