Murine interstitial nephritis. V. The auto-induction of antigen-specific Lyt-2+ suppressor T cells diminishes the expression of interstitial nephritis in mice with antitubular basement membrane disease.
We observed the emergence of an antigen-specific Lyt-2+ suppressor T cell after the i.v. injection of tubular antigen-derivatized lymphocytes into mice already immunized to produce interstitial nephritis. The auto-induction of these suppressor T cells effectively attenuated both the expression of renal injury and a delayed-type hypersensitivity response to tubular antigen. This suppressive effect was also genetically restricted by gene products in I-J and Igh-1. Although this suppressor system had a marked inhibitory effect on the nephritogenic effector cell repertoire, there was no diminution of titers of antibodies to the tubular basement membrane. Our results demonstrate a protective role for antigen-specific suppressor cells in autoimmune renal injury, and the strategy for their induction may have important therapeutic implications for other immune-mediated disorders.
Mann
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Neilson
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D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D000950:Antigens, Ly; D001323:Autoantibodies / Q000096:biosynthesis; D001324:Autoantigens / Q000008:administration & dosage / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics; D007116:Immunization, Passive; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007684:Kidney Tubules / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000637:transplantation
D000941:Antigens; D000950:Antigens, Ly; D001323:Autoantibodies; D001324:Autoantigens; D000939:Epitopes; D006183:H-2 Antigens; D007143:Immunoglobulin Heavy Chains; C035812:renal tubular antigen