Once-daily naftifine cream 1% in the treatment of tinea cruris and tinea corporis.
Seventy patients with tinea cruris or tinea corporis were treated with naftifine cream 1% or vehicle once daily for 4 weeks in this double-blind, randomized study. After two weeks, the patients using naftifine had a significantly higher mycologic cure rate than the vehicle-treated patients (79% vs. 31%, p less than 0.001), and they showed significantly better resolution of signs and symptoms. Statistically significantly differences favoring naftifine over its vehicle were found throughout the treatment period and 2 weeks posttreatment.
Jordon
R E
RE
Department of Medicine, University of Texas Health Science Center, Houston.
Rapini
R P
RP
Rex
I H
IH
Katz
H I
HI
Hickman
J G
JG
Bard
J W
JW
Medansky
R S
RS
Lew-Kaya
D A
DA
Sefton
J
J
DeGryse
R E
RE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000499:Allylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000588:Amines / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006119:Groin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011897:Random Allocation; D014005:Tinea / Q000188:drug therapy*
D000588:Amines; D000935:Antifungal Agents; D009824:Ointments; D000499:Allylamine; C029178:naftifine