Encephalitogenic peptide and platelet aggregation in multiple sclerosis.
Platelet aggregation (PA) stimulated by encephalitogenic peptide (EP) and PA induced by ADP were measured in 83 multiple sclerosis (MS) patients and 70 control subjects with other neurological diseases (OND). EP-stimulated PA was significantly increased in MS patients as compared with the controls. There was no significant difference in ADP-induced PA between patients with MS and OND. The results are discussed in terms of EP-stimulated platelets playing a role in the pathogenesis of MS by affecting the venular permeability of the brain.
Prosiegel
M
M
Neu
I
I
Mehlber
L
L
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002199:Capillary Permeability / Q000187:drug effects; D003711:Demyelinating Diseases / Q000097:blood / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000494:pharmacology*; D009422:Nervous System Diseases / Q000097:blood / Q000503:physiopathology; D010974:Platelet Aggregation / Q000187:drug effects*; D011128:Polyradiculopathy / Q000097:blood / Q000503:physiopathology
D004676:Myelin Basic Protein; D000244:Adenosine Diphosphate