[Cultivation of the rabies virus in the continuous kidney cell line 4647 from the green marmoset].
Continuous cells of green monkey kidney 4647 were found to be highly sensitive to three variants of the Vnukovo-32 vaccine strain of rabies virus preliminarily adapted to the primary line of Syrian hamster kidney cells. The virus litre increased with passages in the 4647 cell culture. The resulting virus variants had sufficient immunogenic potency. The time course of virus replication at a temperature of 32 degrees C was studied. The heteroploid cell line 4647 was found to be promising for manufacture of medical and veterinary cultural rabies vaccines.
Aksenova
T A
TA
Mironova
L L
LL
Grachev
V P
VP
Selimov
M A
MA
Preobrazhenskaia
N K
NK
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002522:Chlorocebus aethiops; D000939:Epitopes / Q000032:analysis; D007668:Kidney; D011819:Rabies Vaccines / Q000302:isolation & purification; D011820:Rabies virus / Q000254:growth & development* / Q000276:immunology; D014776:Virus Cultivation / Q000379:methods
D000956:Antigens, Viral; D000939:Epitopes; D011819:Rabies Vaccines
Kul'tivirovanie virusa beshenstva v linii perevivaemykh kletok pochki zelenoĭ martyshki 4647.