Orally induced adjuvant-like arthritis in the rat.
Adjuvant-like arthritis was produced in Sprague-Dawley rats during 14 days of oral administration of 2-amino-5-bromo-6-(3-fluorophenyl)-4(3H)-pyrimidinone. Inflammatory changes about and in the hindlimb joints were similar to those described by Pearson for adjuvant-induced polyarthritis. Lymphoid hyperplasia, elevation of serum IgG levels, and localization of fluorescein-labeled globulin in disseminated inflammatory lesions implicate an immunologic effect. Rats treated twice weekly for 64 days developed lymphocytic thyroiditis and showed less inflammation in the joints.
J E
JE
Gray
E R
ER
Larsen
P E
PE
Fast
R D
RD
Hamilton
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001168:Arthritis / Q000473:pathology*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D001835:Body Weight / Q000187:drug effects; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D006614:Hindlimb; D007074:Immunoglobulin G / Q000032:analysis; D007372:Interferons / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D007074:Immunoglobulin G; C041801:2-amino-5-bromo-6-(3-fluorophenyl)-4(3H)pyrimidinone; D003596:Cytosine; D007372:Interferons