Rapid development of resistance to tumor necrosis factor alpha on Ishikawa human endometrial carcinoma cells.
The human endometrial adenocarcinoma cells IK were found to be highly susceptible for TNF but rapidly developed a resistance to this cytokine. Inhibitors of RNA transcription or protein biosynthesis could not overcome this resistance. Moreover TNF resistance was not associated with increased resistance to hydrogen peroxide. The resistant phenotype remained stable and was not communicated to neighbouring cells in a paracrine manner. The TNF treatment did not induce a multidrug resistance on IK cells. Nude mice bearing xenotransplanted endometrial carcinoma cells did not benefit from TNF treatment.
Department of Obstetrics and Gynecology, Innsbruck University Clinic, Austria.
C
C
Marth
L C
LC
Fuith
E
E
Müller-Holzner
G
G
Daxenbichler
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000473:pathology*
D007202:Indicators and Reagents; D014409:Tumor Necrosis Factor-alpha; D006861:Hydrogen Peroxide