[Role of leukotrienes in shock of immune origin].
In experiments on anesthetized dogs it was shown that leukotriene biosynthesis block with quercetin essentially decreased cardiac and hemodynamic disturbances following the immune heart damage (intracoronary injection of anticardiac serum). Blood pressure was reduced by half, with cardiac output and myocardial contractility also decreasing. Pretreatment with quercetin improved coronary stenosis, removing the second phase (15-60 min) of capacity vessel dilatation reaction (blood deposition).
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D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007114:Immunization; D017999:Leukotriene E4; D016859:Lipoxygenase Inhibitors; D009206:Myocardium / Q000276:immunology; D011794:Quercetin / Q000494:pharmacology; D013189:SRS-A / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000502:physiology*; D013997:Time Factors; D005719:gamma-Globulins / Q000494:pharmacology
D016859:Lipoxygenase Inhibitors; D013189:SRS-A; D005719:gamma-Globulins; D017999:Leukotriene E4; D011794:Quercetin
O roli leĭkotrienov pri shoke immunnogo geneza.