A comparison of membrane marker phenotypes in hairy-cell leukemia and phorbol-ester induced B-cll cells using monoclonal antibodies.
The neoplastic cells from 14 cases of hairy-cell leukemia were investigated in order to determine their membrane phenotype on the basis of their reactivity with a large panel of B-, T-, myeloid/monocytic- and non-lineage restricted monoclonal antibodies. The data were compared to those from monoclonal antibody studies on phorbol-ester (TPA) induced cells from 10 patients with B-type chronic lymphocytic leukemia. The study has so far revealed further evidence for the B-cell nature of hairy-cells leukemia and demonstrates a developmental link between the two cell types, suggesting that hairy-cells represent a more advanced differentiation stage along the B-cell lineage.
Herrmann
F
F
Dörken
B
B
Ludwig
W D
WD
Schwarting
R
R
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis* / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D010641:Phenotype; D013755:Tetradecanoylphorbol Acetate
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000939:Epitopes; D013755:Tetradecanoylphorbol Acetate