Continuous-flow solid-phase synthesis of potential antigenic peptides of hepatitis B virus.
The synthesis of three hepatitis B surface antigens derived from S and pre-S proteins (adw S(140-147), [Tyr148] adw S(139-148), and adw pre-S(120-145)) has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of different scavengers and trimethylsilyl bromide (TMSBr) in trifluoroacetic acid as deprotecting procedures is discussed.
Rabanal
F
F
Laboratory of Peptides, C.I.D., C.S.I.C., Barcelona, Spain.
Haro
I
I
Reig
F
F
García-Antón
J M
JM
D000595:Amino Acid Sequence; D006511:Hepatitis B Antigens / Q000138:chemical synthesis* / Q000302:isolation & purification; D006514:Hepatitis B Surface Antigens / Q000138:chemical synthesis; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology / Q000302:isolation & purification
D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens; D010455:Peptides