[Concept of tumor promoters in hepatocarcinogenesis].
Tumor promotion is defined as 1 step of carcinogenesis. Its intervention occurred when cell DNA was already damaged by a carcinogen and is the support of quiescent mutations. This leads to a complete malignant transformation of the cells by a non genotoxic mechanism. The presence of tumor promoters in our environment, although difficult to estimate, must be taken into account. This requires further research.
Frayssinet
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Laboratoire de pathologie cellulaire, CNRS, Institut de recherches scientifiques sur le cancer, Villejuif, France.
Lafarge-Frayssinet
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D001647:Bile Acids and Salts / Q000009:adverse effects; D002273:Carcinogens / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000009:adverse effects; D008113:Liver Neoplasms / Q000139:chemically induced*; D010634:Phenobarbital / Q000009:adverse effects
D001647:Bile Acids and Salts; D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D010634:Phenobarbital
Le concept de promotion tumorale appliqué au tissu hépatique.