Salivary beta-thromboglobulin: a possible marker for deep vein thrombosis following elective hip surgery.
The concentration of the platelet specific protein B-thromboglobulin, (BTG) was measured in salivary samples obtained pre and postoperatively from 30 patients without evidence of renal disease and having total hip replacement arthroplasty. When postoperative deep-vein thrombosis (DVT) was detected using percutaneous ascending phlebography there was total correlation with elevated salivary BTG levels taking 0.33 micrograms/1 or greater on 2 consecutive occasions or more as indicating a deep venous thrombus. Eight of nine patients with a positive diagnosis of DVT on urokinase scanning would have been diagnosed using the same criterion. However BTG was elevated in a further 5 patients in whom labelled urokinase failed to demonstrate a DVT. These may have been localised in the calf and thus missed by, or lysed prior to, the scanning technique.
Levack
B
B
Bolton
A E
AE
Cooke
E D
ED
Flanagan
J P
JP
D000368:Aged; D001609:Beta-Globulins / Q000378:metabolism*; D003951:Diagnostic Errors; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010690:Phlebography; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator; D001620:beta-Thromboglobulin / Q000378:metabolism*
D001609:Beta-Globulins; D001620:beta-Thromboglobulin; D014568:Urokinase-Type Plasminogen Activator