[Use of a protein-cellulose complex for inducing intensive antibody formation in mice].
The protein-cellulose complex prepared by covalent immobilization of single protein molecules on insoluble cellulose particles was used for priming C57BL/6 and BALB/c mice. The serum antibody content and the number of spleen AFC were assayed after animals' boosting with the soluble protein. Such a complex was shown to have marked advantages over the same protein injected both in complete Freund's adjuvant and in a soluble form, in particular. The immune response of BALB/c mice was more than 10-fold higher than that of C57BL/6 animals.
Korukova
A A
AA
Grigor'eva
O S
OS
Gurvich
A E
AE
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology*; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D005719:gamma-Globulins / Q000494:pharmacology*
D000906:Antibodies; D002483:Cellulose, Oxidized; D004338:Drug Combinations; D005719:gamma-Globulins; D002482:Cellulose; D005620:Freund's Adjuvant
Ispol'zovanie belkovo-tselliuloznogo kompleksa dlia induktsii u mysheĭ intensivnogo antiteloobrazovaniia.