Sequential cerebral blood flow changes in short-term cerebral ischemia in gerbils.
Using quantitative autoradiography, we studied sequential changes in regional cerebral blood flow during and after 2 minutes of bilateral common carotid artery occlusions in 18 gerbils. Occlusion (n = 4) led to severe ischemia in the forebrain (regional cerebral blood flow less than 5% of control [n = 4]) and midbrain (regional cerebral blood flow less than 10% of control), but was morphologically nonlethal. Reperfusion of the brain was complete, and regional cerebral blood flow was not different from control 1 minute after ischemia (n = 4), but hypoperfusion (regional cerebral blood flow 30-50% of control) occurred at 5 minutes (n = 3) and was pronounced at 1 hour (n = 4); at this stage blood flow was inhomogeneous. Hypoperfusion had disappeared at 4 hours (n = 3). Our results indicate that the well-documented sequence of cerebral blood flow changes (i.e., ischemia, initial recovery of blood flow, and delayed hypoperfusion) takes place even after nonlethal cerebral ischemia.
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
H
H
Kato
T
T
Araki
K
K
Kogure
M
M
Murakami
K
K
Uemura
D000818:Animals; D001345:Autoradiography; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005849:Gerbillinae; D008297:Male; D009474:Neurons / Q000473:pathology; D015424:Reperfusion; D013997:Time Factors