IgE response and histamine release in chronic human schistosomiasis.
Total and specific IgE anti-schistosome antibodies were quantitated in 31 patients with chronic schistosomiasis and in 15 controls. Both levels of total and specific IgE were significantly increased in sera of 74 and 68% of infected patients respectively. Histamine release from basophils by specific antigens was assessed using a spectrofluorimetric method. This test was found to be highly significant in all the patients studied. There was a significant correlation between specific IgE levels and histamine release (R = 0.43, p less than 0.05).
F
F
Derouin
B
B
Rouveix
C
C
Sarfati
D000328:Adult; D000818:Animals; D005260:Female; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D012547:Schistosoma / Q000276:immunology; D012548:Schistosoma haematobium / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology*
D007073:Immunoglobulin E