Pancreatic carcinoma in childhood. Report of an autopsy case and a review of the literature.
Clinical and histological findings of pancreatic carcinoma in a 6-year-old boy are reported. Gradual change of histological appearance of the tumor during his course of 3 years and elevation of serum alpha-1-fetoprotein (AFP) are documented. Two biopsy specimens showed immature histological appearance compatible with pancreatoblastoma, and autopsy material showed well-differentiated adenocarcinoma with distinct ductal and acinar differentiation. Electron microscopy demonstrated zymogen-like granules in the apical portion of the neoplastic cells. Immunoperoxidase method demonstrated AFP in the neoplastic cells in addition to alpha-1-antitrypsin. Literature of pancreatic tumor in the young was reviewed, and characteristics of this case were discussed.
Y
Y
Ohaki
K
K
Misugi
Y
Y
Sasaki
M
M
Okudaira
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology* / Q000556:secondary; D002648:Child; D003594:Cytoplasmic Granules / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000032:analysis / Q000556:secondary; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D009363:Neoplasm Proteins; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins