[Cytogenetic effect of pesticides in relation to their hygienic standardization].
Cytogenetic activity of 7 pesticides from various chemical classes was studied on mice bone marrow cells. 6 substances produced a mutagenic effect of different degrees of severity. The dependence of cytogenetic activity on the path, duration of administration into the organism and terms of cell fixation was stated. Hygienic standards and regulations for the production and use of the studied pesticides were developed with regard for the data obtained. The mutagenic effect appeared to be a limiting criterion of harmfulness for 2 substances in the substantiation of their MACs in the air of occupational area.
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D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000235:genetics*; D003582:Cytogenetics; D006540:Herbicides; D007306:Insecticides / Q000008:administration & dosage / Q000592:standards / Q000633:toxicity*; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D009153:Mutagens; D009154:Mutation; D009943:Organophosphorus Compounds; D010795:Phthalic Acids / Q000008:administration & dosage / Q000592:standards / Q000633:toxicity*
D006540:Herbicides; D007306:Insecticides; D009153:Mutagens; D009943:Organophosphorus Compounds; D010795:Phthalic Acids; C007220:dimethyl 2,3,5,6-tetrachloroterephthalate
Tsitogeneticheskaia aktivnost' pestitsidov pri ikh gigienicheskom reglamentirovanii.