[Comparative observation on the invasiveness of different leukemia cells in various organs in vivo].
Using patho-morphological method and transplantation bio-assay, the in vivo invasiveness of leukemia cells in three transplantable mouse T cell leukemia models was comparatively studied. The results showed that the invasion to the liver was consistent, but that to other organs was obviously different. L615 and L7212 leukemia cells preferred bone marrow and spleen to peritoneum but L7811 leukemia cells were just the opposite. Transplantation bio-assay demonstrated that leukemia cells were present in the bone marrow of L615 mice as early as 6 hours after leukemic cell inoculation, but no leukemia cells were detected in the bone marrow of L7811 mice 2 days after inoculation. In the terminal phase, L615 mice bone marrow became filled with leukemia cells, but L7811 mice bone marrow contained only a few leukemia cells. The difference in invasiveness of leukemia cells into organs is probably related to "homing" receptor. The same type of leukemia cells may possess multiple "homing" receptors.
Chu
J X
JX
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
D000818:Animals; D001681:Biological Assay; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D007942:Leukemia, Experimental / Q000473:pathology*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009929:Organ Size; D013154:Spleen / Q000473:pathology