Apparent liver blood flow during pregnancy: a serial study using indocyanine green clearance.
Serial measurements of apparent liver blood flow and cardiac output were performed in 12 women at 12-14, 24-26 and 36-38 weeks of pregnancy and then at 10-12 weeks after delivery. Apparent liver blood flow was calculated from indocyanine green clearance. Cardiac output was measured by Doppler and cross-sectional echocardiography at the aortic valve. Postnatal apparent liver blood flow was 1.81 l/min and no significant change was demonstrated during pregnancy. In contrast cardiac output decreased from 7.46 l/min at 36-38 weeks gestation to 4.90 l/min after delivery. Apparent liver blood flow accounted for 24% of cardiac output during pregnancy. This increased to 37% after delivery.
Royal Postgraduate Medical School, Institute of Obstetrics & Gynaecology, Queen Charlotte's and Chelsea Hospital, London.
S C
SC
Robson
E
E
Mutch
R J
RJ
Boys
K W
KW
Woodhouse
D000328:Adult; D002302:Cardiac Output; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008099:Liver / Q000502:physiology; D008102:Liver Circulation; D008657:Metabolic Clearance Rate; D049590:Postpartum Period; D011247:Pregnancy / Q000502:physiology*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
D007208:Indocyanine Green