Aminoglycoside antibiotics. 7. Dihydrostreptomycin analogues.
Dihydrostreptomycin analogues with structural variations in their guanidino groups were prepared. The analogue with a methyl group on the guanidine at C-1 was nearly as active as dihydrostreptomycin against bacteria. However, the 2-imidazolin-2-ylamino substituent at C-1 eliminated activity. No analogue with a substituent on the C-3 guanidino group was active.
Delaware
D L
DL
Sharma
M S
MS
Iyengar
B S
BS
Remers
W A
WA
Pursiano
T A
TA
D004096:Dihydrostreptomycin Sulfate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004096:Dihydrostreptomycin Sulfate