[Effect of potassium and calcium channel blockers on changes in the transepithelial potential and spike responses of electroreceptors of the ampullae of Lorenzini in the skate].
Action of TEA, 4-AP, Co2+, Cd2+, Cs+, EDTA and verapamile on sensory epithelium of Lorenzinian ampullae was studied in the Black Sea skate Raja clavata. Application of TEA to the basal face of epithelium in current-clamped ampulla caused oscillations of transepithelial potential and oscillatory spike discharges in response to excitatory stimulation. The oscillations were suppressed by Co2+, Cd2+ and EDTA. Application of Cs+ was followed by partial or complete suppression of spike response adaptation. TEA injection into the ampulla produced an increase in the spike frequency reaction and speeding of adaptation. Co2+, Cd2+ and verapamile inside the ampulla caused almost no changes. The contribution of various ionic channels to the function of the electroreceptor cell is discussed.
Broun
G R
GR
Govardovskiĭ
V I
VI
Cherepnov
V L
VL
D015761:4-Aminopyridine; D000200:Action Potentials / Q000187:drug effects; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004560:Electricity; D005399:Fishes / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000502:physiology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D000631:Aminopyridines; D002413:Cations, Divalent; D007473:Ion Channels; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D004492:Edetic Acid; D015761:4-Aminopyridine; D011188:Potassium; D002118:Calcium
Vliianie blokatorov kalievykh o kal'tsievykh kanalov na izmeneniia transépitelial'nogo potentsiala i impul'snye otvety élektroretseptorov ampul Lorentsini skata.