[Combined use of antitubercular drugs and metabolites of the tricarboxylic acid cycle in experimental tuberculosis].
The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.
T A
TA
Sokirko
V I
VI
Maliuk
M T
MT
Klimenko
E I
EI
Suslov
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D007538:Isoniazid / Q000008:administration & dosage*; D008297:Male; D008298:Maleates / Q000008:administration & dosage*; D009930:Organic Chemicals; D013386:Succinates / Q000008:administration & dosage*; D019802:Succinic Acid; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D003692:Delayed-Action Preparations; D008298:Maleates; D009930:Organic Chemicals; D013386:Succinates; C065635:polyzid; C030272:maleic acid; D019802:Succinic Acid; D007538:Isoniazid
Sochetannoe primenenie protivotuberkuleznykh preparatov i metabolitov trikarbonovogo tsikla pri éksperimental'nom tuberkuleze.