Positive interaction of ethanol and kava resin in mice.
1. The lipid soluble extract of the psychoactive beverage kava has hypnosedative properties which can be measured by the length of time that the righting reflex is lost. 2. Ethanol and the lipid soluble extract (kava resin) have been shown greatly to increase each others hypnotic action in mice. Ethanol also increases the toxicity of kava markedly. 3. This interaction of kava and alcohol has important clinical and social consequences since, in contrast to traditional usage, kava is now often taken in conjunction with alcoholic drinks.
Jamieson
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School of Physiology and Pharmacology, University of New South Wales, Kensington, Australia.
Duffield
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D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D020901:Kava; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D004856:Postural Balance / Q000187:drug effects; D012116:Resins, Plant / Q000494:pharmacology*
D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012116:Resins, Plant; D000431:Ethanol