Contribution of immunohistochemistry to the diagnosis of breast cancer in men.
In men with advanced carcinoma of the prostate who have a breast tumour, it is often difficult to distinguish a primary from a secondary breast lesion. The authors describe the case of a 72-year-old man who presented with a poorly differentiated carcinoma in one breast after receiving estrogen therapy for disseminated prostatic cancer. Application of the unlabelled antibody peroxidase-antiperoxidase immunohistochemical method demonstrated prostate-specific antigen in the tumour cells, thus establishing the secondary origin of the lesion. Five controls--men with primary breast cancer--when tested by the same method did not have this marker. The authors conclude that in this clinical context, prostate-specific antigen is a useful marker of breast cancer in men.
Aziz
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Milne
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Solomon
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Jothy
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D000230:Adenocarcinoma / Q000032:analysis / Q000175:diagnosis* / Q000556:secondary; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis / Q000175:diagnosis* / Q000556:secondary; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000276:immunology; D012737:Sex Factors
D000951:Antigens, Neoplasm; D017430:Prostate-Specific Antigen