Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex.
A lymphotropic virus HTLV-III/LAV was recently identified as the etiologic agent of the acquired immune deficiency syndrome (AIDS). In a study of concomitant hepatitis B infections in patients with AIDS or the AIDS-related complex, DNA sequences of hepatitis B virus (HBV) were found in fresh and cultured lymphocytes from patients with AIDS even in the absence of conventional HBV serological markers. Furthermore, the restriction DNA pattern was consistent with the integration of the viral DNA. These results should prompt additional studies to reevaluate a possible role of HBV as a cofactor in AIDS in addition to the HTLV-III/LAV causal agent.
Laure
F
F
Zagury
D
D
Saimot
A G
AG
Gallo
R C
RC
Hahn
B H
BH
Brechot
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology; D006509:Hepatitis B / Q000150:complications; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000032:analysis*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012698:Serologic Tests
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D012194:RNA-Directed DNA Polymerase