[Radiosensitizing effect of interferon synthesis inducers].
The preinjection of inductors of leukocytic interferon synthesis of rapid (poly I.poly C, dextransulfate) and slow (tyloron) types to mice bearing inoculated solid sarcoma 37 considerably increases the efficiency of X-irradiation of tumors: the coefficient of tumor growth inhibition (kappa *) exceeds 1.0, and the number of animals with the completely regressed tumors increases. The effectiveness of the procedure depends on the time of the injection of the preparations and modes of irradiation.
Leonidze
D L
DL
Afanas'ev
G G
GG
Poverennyĭ
A M
AM
Pelevina
I I
II
D000818:Animals; D016264:Dextran Sulfate; D003911:Dextrans / Q000627:therapeutic use; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D011070:Poly I-C / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents; D012511:Sarcoma 37 / Q000532:radiotherapy*; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D013994:Tilorone / Q000627:therapeutic use
D003911:Dextrans; D007369:Interferon Inducers; D011838:Radiation-Sensitizing Agents; D016264:Dextran Sulfate; D013994:Tilorone; D011070:Poly I-C
Radiosensibiliziruiushchee deĭstvie induktorov sinteza interferona.