Enhancement in anti-Semliki Forest virus activity of ds RNA by a muramyl dipeptide.
Antiviral activity of an interferon-inducing mycoviral ds RNA against Semliki Forest virus infection was considerably enhanced by N-palmitoylmuramyl-L-alanyl-D-isoglutamine (PMDP), a new muramyl dipeptide. This enhancement in activity was not due to increased production of interferon, but resulted probably from a PMDP-induced increase in nonspecific resistance to infection. These results indicate that a combined treatment with an interferon inducer and muramyl dipeptide may prove highly useful to control effectively viral infections.
George
C X
CX
Jain
R K
RK
Gupta
C M
CM
Anand
N
N
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000627:therapeutic use*; D000818:Animals; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D051379:Mice; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D012672:Semliki forest virus / Q000187:drug effects*; D014036:Togaviridae Infections / Q000188:drug therapy* / Q000276:immunology
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007372:Interferons