Prediction of probability of carcinogenicity for a set of ongoing NTP bioassays.
Forty-four compounds currently undergoing carcinogenesis bioassay by the National Toxicology Program were submitted to the TOPKAT program for prediction of their potential carcinogenicity. Sixteen compounds could not be handled by TOPKAT. Of the 28 for which predictions were made, 26 (93%) had a confidence level in the estimate of at least moderate. Seventeen were predicted to be carcinogens and 11 non-carcinogens. These results will be compared with the assay results as the assays are completed.
Enslein
K
K
Health Designs, Inc., Rochester, NY 14604.
Blake
B W
BW
Borgstedt
H H
HH
D015197:Carcinogenicity Tests; D002273:Carcinogens; D011336:Probability; D012044:Regression Analysis; D012984:Software; D013329:Structure-Activity Relationship
D002273:Carcinogens