Effects of selenalysine on CHO cells.
Selenalysine, the lysine isolog with the 4-methylene group substituted by a Selenium atom, inhibits growth rate and plating efficiency of Chinese Hamster Ovary (CHO) cells. It does not affect DNA and RNA synthesis, but inhibits protein synthesis. Cells grown in the presence of selenalysine show a reduced viability and an increased cell volume. Almost all the effects of selenalysine on CHO cells can be reversed by lysine, thus indicating that selenalysine acts mainly in competition with lysine by impairing its utilization.
C
C
Cini
R
R
Coccia
C
C
Foppoli
M
M
Canini
M
M
Di Girolamo
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016566:Organoselenium Compounds; D010053:Ovary; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012643:Selenium / Q000494:pharmacology*
D016566:Organoselenium Compounds; C011351:selenalysine; D012313:RNA; D004247:DNA; D012643:Selenium; D008239:Lysine