Homology with hemopexin suggests a possible scavenging function for S-protein/vitronectin.
S-protein is an abundant plasma protein which has recently been shown to be identical to vitronectin and serum spreading factor [(1985) EMBO J. 4, 3153-3157]. It therefore has multiple binding sites for terminal complement complexes, thrombin-antithrombin III, heparin, and a specific cell receptor. In this report a structural and sequence homology with hemopexin is described which suggests that the principle function of S-protein could be as a scavenging molecule, clearing spent complement and coagulation complexes from the circulation.
K K
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Stanley
D000595:Amino Acid Sequence; D001798:Blood Proteins; D004247:DNA; D006023:Glycoproteins; D006466:Hemopexin; D006801:Humans; D012689:Sequence Homology, Nucleic Acid; D019096:Vitronectin
D001798:Blood Proteins; D006023:Glycoproteins; D019096:Vitronectin; D004247:DNA; D006466:Hemopexin