Synergistic effect of K-18 and concomitant hyperthermia for treatment of Lewis lung carcinoma in mice.
We investigated the synergistic anti-tumor effects of K-18 (conjugate of human gamma-globulin and melphalan) and concomitantly administered hyperthermia on Lewis lung carcinoma in mice. The antitumor effect of a subeffective dose of K-18 or an equivalent dose of melphalan alone was enhanced by local hyperthermia. K-18 administration demonstrated a greater potentiation for inhibition of tumor growth than that of melphalan alone. Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. The combined application of K-18 and hyperthermia for treating cancer warrants further study.
Tamada
R
R
Kai
H
H
Sugimachi
K
K
Takenaka
K
K
Hiramoto
Y
Y
Inokuchi
K
K
D000818:Animals; D002277:Carcinoma / Q000628:therapy*; D003131:Combined Modality Therapy; D004338:Drug Combinations / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D000922:Immunotoxins; D008175:Lung Neoplasms / Q000628:therapy*; D008558:Melphalan / Q000378:metabolism / Q000627:therapeutic use*; D051379:Mice; D014018:Tissue Distribution; D005719:gamma-Globulins / Q000378:metabolism / Q000627:therapeutic use*
D004338:Drug Combinations; D000922:Immunotoxins; C045927:K-18 conjugate; D005719:gamma-Globulins; D008558:Melphalan