Plasma codeine and morphine concentrations after a single oral dose of codeine phosphate.
Plasma concentrations of codeine and its O-demethylated metabolite morphine were determined, by a sensitive and specific high performance liquid chromatography (HPLC) method, following a single oral dose of 60 mg codeine phosphate. Ten healthy volunteers received a single dose of 60 mg codeine phosphate. The plasma concentrations were analyzed for codeine and morphine at the 0.5, 1, 3, and 6 hours postdosing. The mean peak codeine plasma concentrations and tmax (time to reach maximum plasma codeine concentrations) were 88.1 ng/mL and 1.2 hours. Mean maximum concentrations of metabolically produced morphine was 2.7 +/- 0.6 ng/mL. The mean ratio of areas under the plasma concentration-time curves for morphine and codeine was 0.027. Thus, free morphine represented only about 2.7 +/- 1.8% of the free codeine area in each case.
Shah
J C
JC
Department of Drug Metabolism, Syntex Research, Palo Alto, California 94303.
Mason
W D
WD
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003061:Codeine / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D009020:Morphine / Q000097:blood* / Q000493:pharmacokinetics
D009020:Morphine; D003061:Codeine