A refined experimental model for proliferative vitreoretinopathy.
Animal models of proliferative vitreoretinopathy (PVR) in which the intact vitreous is injected with large numbers of tissue cultured fibroblasts do not accurately represent the disease as it is found in humans. A refined model of PVR is presented, in which the vitreous is compressed and partially detached using intravitreally injected perfluorpropane, followed by injection of 25,000 homologous fibroblasts. Proliferation occurred on the retinal surface, causing retinal detachments with the same frequency as models using greater numbers of cells.
D B
DB
Chandler
F A
FA
Quansah
T
T
Hida
R
R
Machemer
D000818:Animals; D005128:Eye Diseases / Q000209:etiology; D005347:Fibroblasts; D005466:Fluorocarbons; D007267:Injections; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic / Q000209:etiology; D011817:Rabbits; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D012164:Retinal Diseases / Q000209:etiology*; D012167:Retinal Perforations / Q000209:etiology; D014822:Vitreous Body
D005466:Fluorocarbons; C042852:perflutren