Murine interleukin 1 stimulates alpha 2-macroglobulin synthesis in rat hepatocyte primary cultures.
In rat hepatocyte primary cultures recombinant interleukin 1 was found to stimulate alpha 2-macroglobulin synthesis, whereas albumin synthesis was decreased. Although recent experiments gave evidence that a hepatocyte-stimulating factor distinct from interleukin 1 must exist, we conclude that interleukin 1 exerts a direct effect on hepatocytes by inducing acute-phase protein synthesis.
J
J
Bauer
W
W
Weber
T A
TA
Tran-Thi
G H
GH
Northoff
K
K
Decker
W
W
Gerok
P C
PC
Heinrich
D000418:Albumins / Q000096:biosynthesis; D000818:Animals; D002478:Cells, Cultured; D011232:Chemical Precipitation; D007120:Immunochemistry; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D051379:Mice; D051381:Rats; D000511:alpha-Macroglobulins / Q000096:biosynthesis*
D000418:Albumins; D007375:Interleukin-1; D000511:alpha-Macroglobulins