Mu- and delta-opioid receptor-mediated epileptoid responses in morphine-dependent and non-dependent rats.
In 3 different models of opioid epileptogenesis we have utilized opioid receptor antagonists to differentiate the nature and role of opioid receptor subtypes involved in opioid agonist-induced epileptoid responses in rats. Selective mu-opioid receptor agonism can initiate epileptoid responses in non-dependent rats. Delta-opioid agonism is important in sustaining mu-initiated epileptoid responses. A role for mu-opioid receptor stimulation in delta-opioid initiated epileptoid responses remains yet to be clarified. Delta-opioid antagonism does not precipitate classic autonomic and behavioral signs of withdrawal in morphine-dependent rats but blocks epileptoid responses in naloxone-precipitated morphine withdrawal without affecting autonomic and behavioral components of an ongoing withdrawal reaction.
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Dua
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Pinsky
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LaBella
D000818:Animals; D004569:Electroencephalography; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009020:Morphine / Q000009:adverse effects / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
D011957:Receptors, Opioid; D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine; C036405:ICI 154129