Measurement of antigen-specific IgE in nasal secretions of patients with perennial rhinitis.
Sixteen of 53 patients with rhinitis had positive skin tests corresponding with serum-specific IgE (RAST). Concomitant positive nasal secretion (NS) RAST was found in 10/16. Four patients with both negative skin tests and serum RAST had positive NS RAST. In a subset of patients with perennial rhinitis, specific IgE may be detected only in NS. Further studies are necessary to document the clinical relevance of such NS IgE antibodies.
Small
P
P
Barrett
D
D
Frenkiel
S
S
Rochon
L
L
Cohen
C
C
Black
M
M
D000042:Absorption; D000293:Adolescent; D000328:Adult; D001666:Binding Sites, Antibody; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism*; D011852:Radioallergosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000276:immunology*; D012882:Skin Tests
D000939:Epitopes; D007073:Immunoglobulin E