[Heavy water inhibition of the transport of alkaline cations across the muscle membrane. I. A comparison of different types of sodium transfer].
The sodium efflux from the frog sartorius muscle into the media of different ion composition, prepared with ordinary and heavy water, was measured by radiotracer and flame-emission techniques. About the half of the sodium in muscles was substituted for lithium. The ouabain-sensitive, as well as external potassium- and external sodium-dependent components of the efflux were found to be totally inhibited in D2O, whereas the residual efflux observed in sodium- and potassium-free magnesium medium was diminished in D2O only by one half. A conclusion is made that the decrease in sodium efflux in D2O is due to the inhibition of sodium transfer through the Na, K-ATPase transport system.
A A
AA
Vereninov
I S
IS
Ivakhniuk
F V
FV
Toropova
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003903:Deuterium; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D011896:Rana temporaria; D012413:Rubidium / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D012996:Solutions; D014867:Water / Q000494:pharmacology
D007473:Ion Channels; D012996:Solutions; D014867:Water; D010042:Ouabain; D008094:Lithium; D012964:Sodium; D003903:Deuterium; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D012413:Rubidium
Tormozhenie tiazheloĭ vodoĭ transporta shchelochnykh kationov cherez myshechnuiu membranu. I. Sravnenie raznykh vidov perenosa natriia.