Indirect antiglobulin test and anti-D prophylaxis in hereditary persistence of fetal hemoglobin.
The indirect antiglobulin test was used to assess the efficacy of anti-D prophylaxis in two Rh negative women with hereditary persistence of fetal hemoglobin. Saturation of all D sites by passive antibody should be followed by indirect antiglobulin positivity due to excess administered anti-D. In hereditary persistence of fetal hemoglobin, all red cells have fetal hemoglobin making the acid elution test (Kleihauer-Betke smear) to detect feto-maternal hemorrhage useless. The indirect antiglobulin test is recommended in patients with hereditary persistence of fetal hemoglobin.
Fadel
H E
HE
Krauss
J S
JS
D000328:Adult; D003298:Coombs Test; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000628:therapy; D012203:Rh Isoimmunization / Q000175:diagnosis / Q000628:therapy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D007136:Immunoglobulins; D012204:Rh-Hr Blood-Group System; D005319:Fetal Hemoglobin