T lymphocyte clones and experimental autoimmune diseases.
This article reviews some of the lessons derived from our use of T lymphocyte lines and clones to study three experimental autoimmune diseases: experimental autoimmune encephalomyelitis, experimental autoimmune thyroiditis and adjuvant arthritis. In each of these disease models we have raised lines and clones of T lymphocytes of the helper phenotype that are specifically autoimmune. These T lymphocytes were used to investigate the pathogenesis of disease. Lines and clones were also exploited to induce resistance to disease.
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D000276:Adjuvants, Immunologic / Q000276:immunology; D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D002999:Clone Cells; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D051379:Mice; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004676:Myelin Basic Protein; D013954:Thyroglobulin