Ventricular arrhythmogenic dose of epinephrine in dogs and cats anesthetized with tiletamine/zolazepam and halothane.
The ventricular arrhythmogenic dose of epinephrine (ADE) was determined in 6 dogs anesthetized with halothane alone or with halothane after injection of tiletamine/zolazepam (TZ). Respiratory rate and tidal volume were controlled and sodium bicarbonate was administered to maintain arterial pH and blood gas values within reference range. Heart rate and arterial blood pressure were recorded during determination of the ADE. The ADE (mean +/- SD) was no different during anesthesia with use of halothane alone (8.9 +/- 4.3) than it was when injections of TZ preceded administration of halothane (6.7 +/- 2.8). Tiletamine/zolazepam was also administered IV immediately after determination of the ADE during halothane-induced anesthesia. The TZ administered in this manner did not alter the ADE. Blood pressure and heart rate were significantly greater during infusion of epinephrine than immediately prior to infusion. The administration of TZ did not alter blood pressure response. The ADE was also determined in 6 cats anesthetized with halothane preceded by administration of TZ. The ADE (mean +/- SD) was 0.7 +/- 0.23 micrograms/kg, a value similar to that reported for cats during anesthesia with halothane alone.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210-1089.
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Bednarski
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Muir
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000662:veterinary*; D001381:Azepines; D002415:Cats; D003510:Cyclohexanes; D004285:Dogs; D004347:Drug Interactions; D004837:Epinephrine / Q000008:administration & dosage*; D006221:Halothane; D006352:Heart Ventricles; D013992:Tiletamine; D015041:Zolazepam
D001381:Azepines; D003510:Cyclohexanes; D013992:Tiletamine; D015041:Zolazepam; D006221:Halothane; D004837:Epinephrine