Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.
Synthetic atrial natriuretic peptide, containing 26 amino acids in the rat sequence, L-364, 343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 micrograms/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 micrograms Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.
J P
JP
Bussien
J
J
Biollaz
B
B
Waeber
J
J
Nussberger
G A
GA
Turini
H R
HR
Brunner
F
F
Brunner-Ferber
H J
HJ
Gomez
E S
ES
Otterbein
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010446:Peptide Fragments; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply
D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; C043970:atrial natriuretic factor 26, rat