Impairment of renal function due to sulphinpyrazone after coronary artery bypass surgery: a prospective double-blind study.
In this randomized, double-blind, placebo-controlled trial the renal function was studied in 60 patients recovering from coronary artery bypass surgery treated with a daily dose of 800 mg sulphinpyrazone (SP) or 880 mg acetylsalicylic acid (ASA) or placebo. Serum creatinine level increased (p less than 0.05) during the first 2 days of SP treatment, but returned to its baseline level within 4 days under maintained therapy; during ASA and placebo therapy no significant changes occurred. Serum urea levels decreased (p less than 0.01) during ASA and placebo treatments as time from surgery subsided; the decrease of serum urea level was delayed in the SP group compared with the ASA and placebo groups. Urinary excretion of prostaglandin E2 (PGE2) was significantly decreased (p less than 0.01) during ASA treatment; in the SP group, urinary PGE2 excretion tended also to decrease during the first days of treatment, the decrease being significant only on the 4th day (p less than 0.01). The urinary excretion of kallikrein decreased significantly only in the SP group (p less than 0.01), while the changes in the ASA and placebo group were not significant. We suggest that the rapidly reversible acute renal impairment during SP therapy was probably due to a transient renal ischemia caused by a drug-related decrease in urinary kallikrein excretion rather than by renal prostaglandin inhibition.
Boelaert
J
J
Lijnen
P
P
Robbens
E
E
Rocher
A
A
Daneels
R
R
Schurgers
M
M
Amery
A
A
D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D003404:Creatinine / Q000097:blood / Q000652:urine; D015232:Dinoprostone; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D011446:Prospective Studies; D011458:Prostaglandins E / Q000652:urine; D011897:Random Allocation; D013442:Sulfinpyrazone / Q000009:adverse effects*; D014508:Urea / Q000097:blood
D011458:Prostaglandins E; D014508:Urea; D003404:Creatinine; D007610:Kallikreins; D015232:Dinoprostone; D013442:Sulfinpyrazone