[Hemodynamic effects of nifedipine on pulmonary hypertension secondary to congenital heart disease with shunts].
Ten patients (pts) with pulmonary hypertension (PAH) secondary to congenital heart diseases (CHD) with left to right and bidirectional shunts were studied by right heart catheterization. After getting the control hemodynamic data, pts were given nifedipine (NIF) capsule 10-20 mg sublingually and their pulmonary artery pressure (PAP), systemic blood pressure (SBP), heart rate (HR) were monitored for 60 minutes and the hemodynamic data were redetermined. The results showed that the PAP as well as SBP was decreased and the quantity index of left to right shunt (L-R QI) was also reduced by NIF in L-R shunt group (3/10). In bidirectional shunts group (7/10), 4/7 cases showed total pulmonary artery resistance index (TPRI), pulmonary artery resistance index (PARI) were decreased by 29% (P less than 0.01) and 30% (P less than 0.05) respectively without seriously increased R-L shunts. The other 3/7 pts' TPRI, PARI were increased while systemic vascular resistance index (SVRI) was lowered by 41% (P less than 0.05). The quantity index of pulmonary blood flow (Qlp) was decreased by 30 (P less than 0.05) quantity index of right to left shunt R-L QI was increased sharply by 138% (P less than 0.05) while L-R QI decreased by 76% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Affiliated Hospital of Dalian Medical College.
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Zhou
D000293:Adolescent; D000328:Adult; D002648:Child; D004374:Ductus Arteriosus, Patent / Q000150:complications*; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*
D009543:Nifedipine