Ratios between growth parameters for the prenatal ultrasonographic diagnosis of skeletal dysplasias.
The clinical applicability and usefulness of nine ratios that express the relation between particular fetal growth parameters were tested in ten fetuses affected by skeletal dysplasia. The results were compared with the ratios calculated from five growth-retarded fetuses without structural anomalies. Femur/foot, femur/head circumference, head circumference/thoracic circumference and abdominal circumference/thoracic circumference ratios are useful additional parameters for the prenatal ultrasonographic diagnosis of skeletal dysplasias. They reduce the problem of an unknown gestational age and help to distinguish between fetal skeletal dysplasia and intra-uterine growth-retardation caused by other factors.
Department of Obstetrics and Gynecology, Free University Hospital, Amsterdam, The Netherlands.
J T
JT
Brons
J J
JJ
van der Harten
H P
HP
van Geijn
J W
JW
Wladimiroff
A
A
Reuss
P
P
Stewart
C J
CJ
Meijer
N F
NF
Arts
D001846:Bone Development / Q000502:physiology*; D001848:Bone Diseases, Developmental / Q000175:diagnosis*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D014463:Ultrasonography