[Effect of substances modifying calcium movement on the contractility of cultured cardiac cells].
Cultured cardiac cells from newborn rats were found to be sensitive to the positive or negative inotropic effect of agents capable of interfering with calcium movements. Calcium entry blockers were found specially potent, since diltiazem and nifedipine were still active at concentration of 1 X 10(-9) M. Such a bioassay system seems therefore convenient to compare the relative potency of drugs belonging to this pharmacological class.
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D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D004110:Diltiazem / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007473:Ion Channels; D010656:Phenylephrine; D002110:Caffeine; D006632:Histamine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D007545:Isoproterenol; D007099:Imipramine
Influence de substances modificatrices des mouvements de calcium sur la contractilité des cellules cardiaques cultivées.