Neuropeptide functions in the fish gut.
Several neuropeptides, more or less related to their mammalian counterparts, are present in the enteric nervous system in fish, and may function as neurotransmitters, cotransmitters or neuromodulators in this system. Excitatory effects on fish gut smooth muscle are found with bombesin, substance P and neurotensin. VIP and bombesin are inhibitory in some preparations and metenkephalin and somatostatin give varying responses. Of the more closely studied neuropeptides, a bombesin-like peptide may be involved in a cofunction with acetylcholine in the excitation of gut motility. One or more tachykinins may be involved in different mechanisms controlling the gut motility, directly or indirectly via, e.g., serotonergic neurons. Bombesin, a tachykinin and VIP may control gastric secretion, and VIP may have vasodilatory functions as well as inhibitory functions on gut motility at least in some species.
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D000818:Animals; D001839:Bombesin / Q000502:physiology; D002766:Cholecystokinin / Q000502:physiology; D004064:Digestive System / Q000294:innervation; D004068:Digestive System Physiological Phenomena; D004745:Enkephalins / Q000502:physiology; D005399:Fishes / Q000502:physiology*; D005755:Gastrins / Q000502:physiology; D005769:Gastrointestinal Motility; D009419:Nerve Tissue Proteins / Q000502:physiology*; D013373:Substance P / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D004745:Enkephalins; D005755:Gastrins; D009419:Nerve Tissue Proteins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin; D001839:Bombesin