Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
After head injury, many complex neurochemical events occur locally, at the site of initial injury, and globally, as a result of secondary phenomena. Neurochemical alterations in the cerebrospinal fluid after injury can be utilized to reflect these events. The authors review the role of the cerebrospinal fluid in the treatment of head injury as it relates to the diagnosis, prognosis, and further elucidation of the pathophysiological manifestations of head injury at the cellular and biochemical level.
R A
RA
Bakay
K M
KM
Sweeney
J H
JH
Wood
D000109:Acetylcholine / Q000134:cerebrospinal fluid; D001929:Brain Edema / Q000134:cerebrospinal fluid; D001930:Brain Injuries / Q000134:cerebrospinal fluid*; D002118:Calcium / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004298:Dopamine / Q000134:cerebrospinal fluid; D005231:Fatty Acids, Unsaturated / Q000134:cerebrospinal fluid; D006632:Histamine / Q000134:cerebrospinal fluid; D006801:Humans; D007610:Kallikreins / Q000134:cerebrospinal fluid; D007705:Kinins / Q000134:cerebrospinal fluid; D007773:Lactates / Q000134:cerebrospinal fluid; D019344:Lactic Acid; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D011188:Potassium / Q000134:cerebrospinal fluid; D011453:Prostaglandins / Q000134:cerebrospinal fluid; D011773:Pyruvates / Q000134:cerebrospinal fluid; D019289:Pyruvic Acid; D012701:Serotonin / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D005231:Fatty Acids, Unsaturated; D007705:Kinins; D007773:Lactates; D004676:Myelin Basic Protein; D018377:Neurotransmitter Agents; D011453:Prostaglandins; D011773:Pyruvates; D012701:Serotonin; D019344:Lactic Acid; D006632:Histamine; D019289:Pyruvic Acid; D007610:Kallikreins; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine