Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.
Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.
W J
WJ
van der Giessen
B
B
Schoutsen
J G
JG
Tijssen
P D
PD
Verdouw
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003327:Coronary Disease / Q000503:physiopathology*; D011464:Epoprostenol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D016285:Iloprost; D010477:Perfusion; D013552:Swine
D002317:Cardiovascular Agents; D000255:Adenosine Triphosphate; D011464:Epoprostenol; D016285:Iloprost