[Contractile capacity of isolated flaps from the aorta of rats with stable arterial hypertension caused by the prolonged administration of cerebrosides].
A study was made of the contractility of smooth muscle cells of abdominal aorta strips of noninbred white rats with stable arterial hypertension induced by protracted intraperitoneal injection of cerebrosides isolated from cattle brain. It was demonstrated that as compared with normotensive animals, smooth muscle cells of the animals' arteries are characterized by the increased influx of extracellular calcium via slow potential-dependent calcium channels and hypersensitivity to noradrenaline and serotonin.
S A
SA
Mirzoian
O P
OP
Sotskiĭ
E S
ES
Sekoian
A V
AV
Topchian
G M
GM
Sarkisova
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D002554:Cerebrosides / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D007473:Ion Channels / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D002554:Cerebrosides; D007473:Ion Channels; D002118:Calcium
Sokratitel'naia sposobnost' izolirovannykh loskutov iz aorty krys so stoĭkoĭ arterial'noĭ gipertenzieĭ, vyzvannoĭ dlitel'nym vvedeniem tserebrozidov.