Effect of DL-ethionine on blood clearance of 99mTc-phytate in dogs.
The effect of DL-ethionine (EthN) on the blood clearance of 99mTc-phytate (99mTc-P) in dogs was examined, and the blood clearance test of 99mTc-P was compared with the cases of the serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in dogs increased dose-dependently after the administration of EthN. The disappearance rate of 99mTc-P from blood in dogs decreased with the increase in dose of EthN and with the passage of time after EthN administration. Changes of the blood clearance of 99mTc-P after EthN treatment in dogs may be influenced by the disorder in the hepatocytes. The blood clearance test of 99mTc-P in dogs showed a reaction for the acute hepatic dysfunction induced by EthN equally to the serum transaminase and bilirubin test.
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
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Shibata
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Kohno
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005001:Ethionine / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010833:Phytic Acid / Q000493:pharmacokinetics*; D012737:Sex Factors
D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin; D005001:Ethionine