Coagulation and fibrinolytic systems during the course of erysipelas and necrotizing fasciitis and the effect of heparin.
Necrotizing fasciitis (NF) is a grave infection of the skin leading to gangrene of the integument and often having a complicated and prolonged course. Studies on blood coagulation and fibrinolysis were done in 15 patients with NF and compared with 5 cases of erysipelas (E). In both conditions local fibrin deposition occurred initially in their course, but it was quantitatively more pronounced in NF than in E. Fibrinolysis decreased and stayed low at the site of NF up to 5 months (median) after discharge from hospital. Fibrinogen and activities of several plasma serine proteinases modifying coagulation were increased during the course of both diseases and even at the follow-up. Factor XII was decreased during the first week in E but a transient drop was present in NF only on days 3 and 4. The treatment of NF consists of high doses of appropriate antibiotics instituted early in its course. A beneficial effect of 300-500 IU heparin/kg/day was suggested from this open study. The hard induration preceding the appearance of skin gangrene was inhibited, if heparin was given early in the course of NF. We conclude that the enhanced fibrin deposition and vascular occlusions in the skin are the basis for most complications present in NF.
H
H
Hammar
B
B
Sverdrup
E
E
Borglund
M
M
Blombäck
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001777:Blood Coagulation; D010450:Endopeptidases / Q000097:blood; D004886:Erysipelas / Q000097:blood* / Q000382:microbiology; D005169:Factor VIII / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism; D005208:Fasciitis / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012697:Serine Endopeptidases; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005338:Fibrin Fibrinogen Degradation Products; D005169:Factor VIII; D005174:Factor XII; D005337:Fibrin; D005340:Fibrinogen; D010450:Endopeptidases; D012697:Serine Endopeptidases