[Influence of Rhizoma pinelliae on the occurrence of micronucleus in bone marrow polychromatic erythrocytes (PCE) in mice and frequencies of SCE in cultured human lymphocytes].
Contradictory effects of Rhizoma Pinelliae have been reported in pregnant mice, rats and rabbits, because the decoction of Rhizoma Pinelliae has obvious embryotoxicity. This paper was obtain an experimental analysis of the frequencies of micronucleus of bone marrow polychromatic erythrocytes (PCE) in mice and sister chromatid exchange (SCE) in cultural lymphocytes of human. The results showed that the decoction of Rhizoma Pinelliae neither induces the occurrencies of micronucleus nor SCE frequencies. Therefore, it may be concluded that the decoction does not have toxicogenetical effects.
Institute of Chinese Materia Medica, China Academy of TCM, Beijing.
S
S
Yang
M
M
He
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015162:Micronucleus Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004365:Drugs, Chinese Herbal