[Effect of interferons on the activity of human tumor degeneration factor (TDF)].
KB cells were cultivated in the well with tumor-degenerating factor (TDF) and the natural and recombinant interferons. TDF alone induced the degenerative changes of the KB cells and formed the cell-free area, but the interferons alone did not induce the changes and did not form the cell-free area. When KB cells were cultivated with TDF and natural interferons (HuIFN-alpha, -beta and -gamma), the cell-free area was enlarged. Particularly, HuIFN-gamma enhanced the TDF activity most strongly. The recombinant interferons (HuIFN-alpha, -beta and -gamma) also augmented in the same ways as the natural interferons.
Imanishi
J
J
Tanaka
A
A
Matsuoka
H
H
Kakui
Y
Y
Uemura
H
H
Imanishi
T
T
Nishino
H
H
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002460:Cell Line; D004357:Drug Synergism; D007370:Interferon Type I / Q000008:administration & dosage; D007372:Interferons / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D000970:Antineoplastic Agents; D007370:Interferon Type I; D007372:Interferons
Influence des interférons sur l'activité du facteur humain de dégénérescence tumorale (FDT).