Cytochemical examination of acid phosphatase and beta-glucuronidase enzymes in low-grade B cell non-Hodgkin's lymphomas.
The differential diagnostic significance of acid phosphatase and beta-glucuronidase were studied in 77 cases of low-grade B cell non-Hodgkin's lymphomas. In most cases the results of cytochemical enzyme studies performed on malignant cells of the bone marrow were evaluated. B cell chronic lymphocytic leukaemia, centrocytic and centroblastic/centrocytic lymphomas were characterized by a weak or a negative acid phosphatase and beta-glucuronidase activity. Stronger positivity was observed in immunocytoma and in Waldenström's macroglobulinaemia, while the highest activity was found in multiple myeloma. Hairy cell leukaemia of B cell origin showed intensive tartrate-resistant acid phosphatase activity. The cytochemical examination of these lysosomal enzymes may be useful in the diagnosis of low-grade malignant lymphomas of B cell origin by completing other methods.
Telek
B
B
Pecze
K
K
Kiss
A
A
Altorjay
I
I
Rak
K
K
D000135:Acid Phosphatase / Q000378:metabolism*; D000328:Adult; D001402:B-Lymphocytes / Q000201:enzymology; D001853:Bone Marrow / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000201:enzymology; D007945:Leukemia, Lymphoid / Q000201:enzymology; D008223:Lymphoma / Q000201:enzymology*; D008224:Lymphoma, Follicular / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D009101:Multiple Myeloma / Q000201:enzymology; D008258:Waldenstrom Macroglobulinemia / Q000201:enzymology
D000135:Acid Phosphatase; D005966:Glucuronidase