Augmentation of human polymorphonuclear leukocyte adherence by interferon.
Augmentation of human polymorphonuclear leucocyte adherence by alpha and gamma interferons occurred as early as 2 min after incubation. Enhancement of adherence occurred at optimal concentrations of 100-1,000 IU/ml. There was synergism between alpha and gamma interferons, but not between two subtypes of alpha interferon, on augmentation of adherence, indicating that alpha and gamma interferons act on different receptors on the polymorphonuclear leucocyte. Heat treatment at 65 degrees C for 30 min abolished the effect of interferon on adherence.
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D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors
D007370:Interferon Type I; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007372:Interferons