Effect of dextran sulfate on the survival time and mitochondrial function of Adriamycin (doxorubicin)-treated mice.
The effect of dextran sulfate on the survival time and mitochondrial function of adriamycin (ADM)-treated mice was studied. ADM-induced toxicity in mice was reduced by treatment with dextran sulfate (60, 100, 300, and 600 mg/kg, sc). The optimum dextran sulfate dose for protection against ADM-induced toxicity in mice was about 200 mg/kg/day (sc) and 100 mg/kg/day (po). Groups treated with dextran sulfate (300 mg/kg) had significantly improved mitochondrial function as measured by oxygen uptake of state 3 (p less than 0.01), dinitrophenol-altered respiration (p less than 0.01), and respiratory control index level (p less than 0.01). From these observations, it was concluded that ADM-induced toxicity due to reduced mitochondrial function can be ameliorated by the membrane stabilizing effect of dextran sulfate.
Shinozawa
S
S
Fukuda
T
T
Araki
Y
Y
Oda
T
T
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016264:Dextran Sulfate; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008930:Mitochondria, Liver / Q000187:drug effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption
D003911:Dextrans; D004317:Doxorubicin; D016264:Dextran Sulfate