Reactivation of bleomycin lung toxicity following oxygen administration. A second response to corticosteroids.
We report a patient who had two episodes of bleomycin lung toxicity with a good clinical response following corticosteroid therapy. The first episode followed treatment with 120 units of bleomycin and was characterized by cough and dyspnea. The second resulted in ARDS following a surgical procedure that used an FIO2 level of 0.33.
Gilson
A J
AJ
Sahn
S A
SA
D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003371:Cough / Q000139:chemically induced; D004357:Drug Synergism; D004417:Dyspnea / Q000139:chemically induced; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects*; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000628:therapy; D010100:Oxygen / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000139:chemically induced; D013736:Testicular Neoplasms / Q000150:complications / Q000628:therapy
D001761:Bleomycin; D010100:Oxygen; D011241:Prednisone