Effects of mononuclear phagocyte system modulating agents on Fc and C3 receptors of adherent cells.
Agents which modulate the mononuclear phagocyte system (MPS) were examined for their effects on Fc and C3 receptors of adherent cells (A-cells) as judged by rosette formation. Dextran sulphate, carrageenan, and immune complexes, known as MPS suppressants, reduced the percentage of receptor-positive A-cells, while levamisole, known as a MPS-activator, increased the percentage in vitro. The changes in the percentage of Fc receptor were parallel to those of the C3 receptor in vitro. The effects of these agents were also examined in vivo.
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Hitomi
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Shimizu
D000818:Animals; D000936:Antigen-Antibody Complex; D002351:Carrageenan / Q000494:pharmacology; D002448:Cell Adhesion; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D066298:In Vitro Techniques; D007978:Levamisole / Q000494:pharmacology; D016177:Macrophage-1 Antigen; D008934:Mitogens / Q000494:pharmacology; D010586:Phagocytes / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011951:Receptors, Complement / Q000187:drug effects*; D011961:Receptors, Fc / Q000187:drug effects*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D003911:Dextrans; D016177:Macrophage-1 Antigen; D008934:Mitogens; D011951:Receptors, Complement; D011961:Receptors, Fc; D007978:Levamisole; D002351:Carrageenan; D016264:Dextran Sulfate