[Effects of chair restraint on plasma enzyme values in the rhesus monkey (Macaca mulatta)].
The purpose of this paper was to examine the effect of chair restraint on plasma enzyme values in the rhesus monkey. Six monkeys were restrained to the monkey chair for eight hours. Creatine phosphokinase (CK) value increased significantly three hours after the onset of restraint and LDH value did eight hours after the onset of restraint. The increase in CK, GOT and GPT values continued for 1 or 2 days after the release from restraint. On the other hand, these plasma enzyme values in non-restraint monkeys showed almost no changes. These results indicate that it is necessary to establish a proper method for the adjustment to chair restraint in the rhesus monkey.
Drug Development Laboratories, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
T
T
Tatsumi
H
H
Komatsu
J
J
Adachi
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008251:Macaca / Q000097:blood*; D008253:Macaca mulatta / Q000097:blood*; D008297:Male; D012149:Restraint, Physical / Q000009:adverse effects*
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase