Demonstration of both immunologically unique and common antigenic determinants in Dirofilaria immitis and Toxocara canis using monoclonal antibodies.
Using an ELISA system, the immunological cross-reactivity between D. immitis and T. canis has been, for the first time, examined on an individual clone-by-clone basis. This study offers a definitive demonstration of the presence of immunologically distinguishable species-specific non-crossreactive antigens and the presence of cross-reactive antigens in antigenic extracts obtained from adult D. immitis and T. canis.
R A
RA
Ott
M
M
Staples
M
M
Weekley
E T
ET
Maggio
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D003429:Cross Reactions; D004183:Dirofilaria immitis / Q000276:immunology*; D004184:Dirofilariasis / Q000175:diagnosis; D004283:Dog Diseases / Q000175:diagnosis; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005370:Filarioidea / Q000276:immunology*; D051379:Mice; D013045:Species Specificity; D014119:Toxocara / Q000276:immunology*; D014120:Toxocariasis / Q000175:diagnosis
D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D000939:Epitopes