Effect of new organophosphates on the membrane of identified central neurons of Helix pomatia L. (Mollusca, Gastropoda).
Effects of two newly synthesized organophosphates were studied on identified neurons of Helix pomatia by microelectrophysiological methods. The single intracellular spikes were processed by computer using a "phase-plane trajectory" method. Dimethoate was also involved as reference substance. The mechanism of action of the substance NE-79297 was found to be similar to that of dimethoate resulting in prolongation of action potentials due to a delayed rectification of the outward current. Phosmethylan (NE-79168), a much more selective compound, altered the membrane parameters in a different way: it affected the slow--mainly calcium-mediated--inward current.
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors; D004117:Dimethoate / Q000494:pharmacology; D004553:Electric Conductivity; D006372:Helix, Snails; D007306:Insecticides / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D063086:Organothiophosphates / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D007473:Ion Channels; D063086:Organothiophosphates; C044117:phosmethylan; D004117:Dimethoate