Baseline and interferon-enhanced natural killer cell activity in rheumatoid arthritis.
Natural killer (NK) cell activity against the leukemia cell line K-562 was tested in 45 patients with rheumatoid arthritis (RA) who either had not received any remission-inducing drugs for more than 6 months or had received penicillamine for at least 6 months. Baseline NK cell activity and interferon (IF)-enhanced NK cell activity did not differ from that observed in 45 controls matched for age and sex, and neither NSAID (non steroidal anti-inflammatory drugs) nor penicillamine influenced NK cell activity. There was no correlation between NK cell activity and acute-phase reactants.
Pedersen
B K
BK
Beyer
J M
JM
Klarlund
K
K
Clemmensen
I H
IH
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007372:Interferons / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007951:Leukemia, Myeloid; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000276:immunology
D007372:Interferons