Sea-blue histiocytes in canine ceroid-lipofuscinosis (CCL).
Cells corresponding to sea-blue histiocytes are described in bone marrow aspirates from dogs suffering hereditary ceroid-lipofuscinosis. Sea-blue histiocytes also occur in humans with so-called neuronal ceroid-lipofuscinosis and both exhibit strong autofluorescence. By quantitative fluorometric techniques, each species have similar spectral characteristics and, thus, the English setter with CCL can serve as a useful animal model.
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D
Armstrong
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Gadoth
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Harvey
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D006644:Histiocytes / Q000473:pathology*; D008856:Microscopy, Fluorescence; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology / Q000662:veterinary*; D013194:Staining and Labeling