[Interstitial pneumopathy and amiodarone].
The case of a patient who developed interstitial pneumopathy after 4 1/2 years of treatment with a normal dose of amiodarone is reported. Drug interruption and additional steroid therapy normalized the pulmonary picture and lung function within 4 months. During this period serum iodine, amiodarone, its metabolite desethyl-amiodarone and urinary iodides were measured and the results compared with the improvement of the clinical and radiological situation. Possible interrelationships between the drug and the pneumopathy, and hypotheses regarding pathogenesis are discussed. During long-term amiodarone therapy radiological checks at regular intervals are important.
Tatti
V
V
Ramelli
G
G
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001572:Benzofurans / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D006801:Humans; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
D001572:Benzofurans; D000638:Amiodarone
Pneumopathie interstitielle et amiodarone.