Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response.
The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells. We show in this paper that the same lymphokines similarly control isotype expression in an antigen-specific response acting in concert with a "T cell independent" antigen. In this situation, B cell growth factor II (BCGF II) enhances the production of antigen-specific IgM antibodies, whereas the production of antigen-specific IgG1 antibodies is only observed in the presence of B cell differentiation factor gamma (BCDF gamma). These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses.
H
H
Tesch
W
W
Müller
K
K
Rajewsky
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D000939:Epitopes / Q000276:immunology*; D006133:Growth Substances / Q000502:physiology*; D006241:Haptens / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007376:Interleukin-2 / Q000502:physiology; D015847:Interleukin-4; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000502:physiology*; D051379:Mice; D009596:Nitrophenols / Q000276:immunology; D010648:Phenylacetates; D011994:Recombinant Proteins / Q000502:physiology
D000939:Epitopes; D006133:Growth Substances; D006241:Haptens; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D008222:Lymphokines; D009596:Nitrophenols; D010648:Phenylacetates; D011994:Recombinant Proteins; C026242:4-hydroxy-5-nitrophenyl acetic acid; D015847:Interleukin-4