Fundus-iris fluorescein angiography: evaluation of its use in the diagnosis of rubeosis iridis.
Fundus-iris fluorescein angiography is a technique that allows iris angiography and retinal angiography to be performed simultaneously, using a single injection of dye and a standard retinal fundus camera. We analyzed the ability of this technique to detect rubeosis iridis. In a study of 200 randomly selected angiograms on 400 eyes, the technique was able to detect 97.2% of all eyes with rubeosis iridis (sensitivity), with a false-positive rate of 1%. In 26 eyes (36.6% of all eyes with rubeosis), it was able to detect rubeosis prior to the development of vessels visible by slit-lamp biomicroscopy. The test was able to correctly identify 98.8% of the eyes without rubeosis (specificity), with a false-negative rate of 0.5%. This technique can be performed routinely as part of retinal angiography.
G E
GE
Sanborn
D J
DJ
Symes
L E
LE
Magargal
D000368:Aged; D005069:Evaluation Studies as Topic; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007498:Iris / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008853:Microscopy; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging