A quantitation of myelin-associated glycoprotein and myelin basic protein loss in different demyelinating diseases.
The loss of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin-embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.
Gendelman
H E
HE
Pezeshkpour
G H
GH
Pressman
N J
NJ
Wolinsky
J S
JS
Quarles
R H
RH
Dobersen
M J
MJ
Trapp
B D
BD
Kitt
C A
CA
Aksamit
A
A
Johnson
R T
RT
D002490:Central Nervous System / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology*; D004679:Encephalomyelitis / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007968:Leukoencephalopathy, Progressive Multifocal / Q000473:pathology; D008457:Measles / Q000473:pathology; D009103:Multiple Sclerosis / Q000473:pathology; D004676:Myelin Basic Protein / Q000378:metabolism*; D009185:Myelin Proteins / Q000378:metabolism*; D009186:Myelin Sheath / Q000648:ultrastructure; D018992:Myelin-Associated Glycoprotein; D009413:Nerve Fibers, Myelinated / Q000473:pathology
D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein