Substance K, a novel tachykinin injected bilaterally into the ventral tegmental area of rats increases behavioral response.
Novel tachykinins such as substance K and neuromedin K have been identified in the mammalian CNS. Bilateral injections of substance K and related peptides as well as of substance P into the dopamine cell body area of the ventral tegmental area caused dose-dependent increases in locomotor activity and rearing, in rats. As this behavior was blocked by the pretreatment with haloperidol (0.1 mg/kg, i.p.), the activation of dopaminergic systems may be involved in the hypermotility induced by the administration of substance K.
Takano
Y
Y
Takeda
Y
Y
Yamada
K
K
Kamiya
H
H
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D015288:Neurokinin A; D015287:Neurokinin B; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology; D013681:Tegmentum Mesencephali / Q000187:drug effects*; D013997:Time Factors
D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B; D006220:Haloperidol; D004298:Dopamine