Serotonin and schizophrenia: correlations between serotonergic activity and schizophrenic motor behavior.
Increased serotonergic activity in animals has been associated with a variety of stereotyped motor behaviors. In addition, serotonin facilitates brainstem, reticular, and spinal motor neuronal activity implicated in the expression of these behaviors. This report presents positive correlations between both peripheral (platelet serotonin levels) and central (cerebrospinal concentrations of 5-hydroxy-indoleacetic acid) measures of serotonin metabolism and the symptom of peculiar or unusual mannerisms and posturing in schizophrenic patients. The findings are discussed in light of the animal behavioral correlates of increased serotonergic activity and the stereotyped affectomotor behavior seen in some schizophrenic patients.
R
R
King
K F
KF
Faull
S M
SM
Stahl
I N
IN
Mefford
S
S
Thiemann
J D
JD
Barchas
P A
PA
Berger
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D009043:Motor Activity / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood*; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000097:blood*; D013239:Stereotyped Behavior / Q000502:physiology*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid