[Potential use of exogenous RNAs for the analysis of the complex effects of biologically active substances].
It has been established in rat experiments that RNA obtained from the liver and renal cortex of animals given hydrocortisone produces in recipients the rise of physical endurance evoked by the hormone. RNA obtained from other organs of these animals and from any test organs of control donors did not influence physical endurance. The key role of the liver and kidneys in the realization of the hydrocortisone effect is likely to be connected with activation of the synthesis of gluconeogenesis enzymes. RNA obtained from the organs of donors premedicated with hydrocortisone reproduced stimulation of gluconeogenesis with hydrocortisone. The use of exogenous RNA holds promise for analysis of complex effects of biologically active substances, since it permits studying separately the components of the effects determined by activation of protein synthesis in definite organs.
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Smirnov
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010807:Physical Endurance / Q000187:drug effects; D014176:Protein Biosynthesis; D012313:RNA / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D003609:Dactinomycin; C021650:hydrocortisone acetate; D012313:RNA; D006854:Hydrocortisone
O vozmozhnosti ispol'zovaniia ékzogennykh RNK dlia analiza slozhnykh éffektov biologicheski aktivnykh veshchestv.