[The effect of an arginine-imbalanced diet on the growth of implanted MM-48 and MH-134 tumors in C3H/He mice].
The arginine-imbalanced diet used in this study was a diet of 27% casein supplemented with 8% arginine monochloride. There was no difference in the serum protein level between C3H/He mice fed a casein diet (N-mice) and mice fed on the arginine-supplemented diet (A-mice). The serum arginine level was increased in the A-mice compared with the N-mice. Significant inhibition of MM-48 tumor incidence was seen in the A-mice when the transplanted tumor was below 5 X 10(6) cells. Growth inhibitory effect against MM-48 tumor was significantly enhanced in the A-mice with i.p. injection of OK-432. Interferon production of spleen cells was increased in the A-mice compared with the N-mice. We speculate that the effect of arginine depends partially on the immune functions in the mice.
Akimoto
M
M
Nakajima
Y
Y
Iwasaki
H
H
Matano
S
S
Hirakawa
H
H
Abe
R
R
Kasai
M
M
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D001798:Blood Proteins / Q000032:analysis; D002364:Caseins / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D007372:Interferons / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H
D000596:Amino Acids; D001798:Blood Proteins; D002364:Caseins; D004044:Dietary Proteins; D007372:Interferons; D001120:Arginine