Mapping of type 1 poliovirus neutralization epitopes.
Several independently variable neutralization epitopes were identified on type 1 poliovirus by testing various field isolates with a panel of homotypic monoclonal antibodies. According to their distribution among viruses tested, neutralization epitopes were classified as strain-specific or variable (V) and cross-reacting or constant (K). Operational, relationship between different neutralization epitopes was analysed by selecting mutants resistant to neutralization with monoclonal antibodies from wild Mahoney and attenuated Sabin type 1 poliovirus. The results of this study and their implication in the characterization of poliovirus antigenic structure by neutralization epitope formulae is discussed.
Blondel
B
B
Crainic
R
R
Dufraisse
G
G
Candréa
A
A
Horaud
F
F
D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics*; D000939:Epitopes / Q000235:genetics; D005814:Genes, Viral; D009154:Mutation; D009500:Neutralization Tests; D017955:Poliovirus / Q000235:genetics / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000276:immunology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral