Serotonin turnover in raphe neurons transplanted into rat hippocampus.
Injections of the neurotoxin, 5,7-dihydroxytryptamine, into rostral raphe nuclei in rats reduced serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus to 35-50% of normal levels but only reduced 5-HT synthesis and catabolism by 20-35%. The small reduction in 5-HT metabolism as compared to depletion of 5-HT suggests that 5-HT turnover was increased in nerve terminals that survived the neurotoxin lesion. Transplantation of rat fetal raphe cells into the 5-HT-denervated hippocampus restored 5-HT and 5-HIAA levels and 5-HT synthesis to 125-150% of normal. This demonstrates that transplantation of fetal raphe tissue can restore metabolism to normal levels in the 5-HT denervated hippocampus.
Auerbach
S
S
Zhou
F
F
Jacobs
B L
BL
Azmitia
E
E
D015116:5,7-Dihydroxytryptamine; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000628:therapy; D006624:Hippocampus / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D011903:Raphe Nuclei / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000378:metabolism*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid