Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth.
2-Acetylaminofluorene (2-AAF) is a moderately cytotoxic drug which is nevertheless capable of promoting diethylnitrosamine-initiated rat liver carcinogenesis in the absence of detectable hepatotoxicity. 2-AAF does not stimulate net growth of the normal liver, but alters hepatocellular ploidy distributions (fewer binucleated and more diploid cells) in a manner indicative of altered growth control. The non-cytotoxic analogue 4-AAF induces a similar ploidy change, and also stimulates liver growth. The possibility should therefore be considered that both agents may specifically elicit a mononucleating growth response in normal liver, which in the case of 2-AAF is antagonized by a general (cytotoxic) growth inhibition. In the promotion of liver carcinogenesis, 2-AAF may act as a growth stimulant upon cytotoxicity-resistant initiated cells; cytotoxicity per se playing no causative role.
Gerlyng
P
P
Department of Tissue Culture, Norwegian Radium Hospital, Montebello, Oslo.
Seglen
P O
PO
D015073:2-Acetylaminofluorene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D008099:Liver / Q000166:cytology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D011003:Ploidies; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D015073:2-Acetylaminofluorene