Is there alpha-adrenergic blockade and/or serotonergic blockade during chronic ketanserin treatment?
Drugs are not absolute in their specificity; the mechanisms by which many agents reduce blood pressure remain disputed. Ketanserin has been shown to have both 5-HT2-serotonergic and alpha 1-adrenergic antagonist activity. Its pharmacological profile makes its designation as a serotonergic antagonist appropriate; however, the relative contributions of at least these two, and perhaps other, mechanisms to the hypotensive effect of ketanserin during long-term oral treatment remain obscure.
S G
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Ball
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Robertson
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007650:Ketanserin; D008303:Malignant Carcinoid Syndrome / Q000188:drug therapy; D010656:Phenylephrine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D010880:Piperidines; D012702:Serotonin Antagonists; D010656:Phenylephrine; D012701:Serotonin; D007650:Ketanserin