[Carcinogenic action of 5-methoxytryptamine related to its transformation into 5-methoxyindolyl-3-acetic acid].
A considerable blastomogenic effect of metabolite serotonin 5-methoxytryptamine (5-MOT) subcutaneously administered for a long time to C57BL/6 mice was established. This effect was decreased noticeably if the further metabolism of 5-MOT into 5-methoxyindolyl-3-acetic acid (5-MIAA) was blocked by pyrazidol. These results explain the fact that the blastomogenic effect of 5-MOT is not direct but is caused by the transformation of 5-MOT into its final carcinogenic metabolite 5-MIAA.
T I
TI
Sergeeva
V I
VI
Romanenko
M O
MO
Raushenbakh
N I
NI
Andreeva
D008735:5-Methoxytryptamine / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014363:Tryptamines / Q000378:metabolism*
D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; C009830:pirlindole
Kantserogennoe deĭstvie 5-metoksitriptamina, sviazannoe s ego prevrashcheniem v 5-metoksiindolil-3-uksusnuiu kisloty.