[A pharmacokinetic study of antibiotics in patients with benign prostatic hypertrophy].
Twenty cases intravenously received 1 g of cefotetan before the transurethral prostatectomy. High serum and prostatic concentrations were obtained and half-lives were 298 minutes for serum and 250 minutes for the prostate. The mean value of their creatinine clearance was as low as 46.6 ml/min and it was found to be the reason why the serum half-life time was longer than that reported for normal volunteers.
K
K
Fujita
T
T
Sayama
S
S
Abe
T
T
Murayama
M
M
Sugimoto
T
T
Hara
D000368:Aged; D015313:Cefotetan; D002513:Cephamycins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000378:metabolism*
D002513:Cephamycins; D015313:Cefotetan