[Effect of terrilitin on the proteolytic activity of the blood and formation of an immunostimulating factor by spleen cells].
Terrilitin is studied for its effect on proteolytic activity of blood and formation of immunostimulating factors by spleen cells. The preparation is shown to induce isolation of the immunostimulating factor (molecular mass 10-15 kDalton) from the spleen cells. The preparation is destroyed by trypsin and RNAase and is stable to the action of lysozyme. Spleen cell factor of the animals with administered terrilitin increases general antiproteolytic activity of the blood serum and concentration of alpha 2-macroglobulins. At the same time, it decreases the general proteolytic activity and callicrein activity of blood serum for syngenic animals.
L G
LG
Prokopenko
G A
GA
Chalyĭ
D000681:Amylases / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology*; D004338:Drug Combinations / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D010447:Peptide Hydrolases / Q000097:blood* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D004338:Drug Combinations; D011480:Protease Inhibitors; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Vliianie terrilitina na proteoliticheskuiu aktivnost' krovi i obrazovanie immunostimuliruiushchego faktora kletkami selezenki.