Anti-HLA-B27 antibodies in sera from patients with gram-negative bacterial infections.
Several forms of seronegative polyarthritis are strongly associated with HLA-B27, and a number of microorganisms have been implicated in the etiology of these diseases. To explain the association between HLA-B27 and arthritis initiated by infection with these organisms, it has been proposed that there is immunologic cross-reactivity between the B27 molecule and 1 or more microbial antigens, and that this cross-reactivity leads to tolerance to such infection and/or to the production of anti-HLA-B27 cross-reactive antibodies. Such cross-reactive antibodies were detected in the sera of only 2 of 63 patients recently infected with Shigella flexneri, Campylobacter jejuni, or Yersinia enterocolitica who had highly significant antibody levels against the infecting bacterial species. Most striking was the absence of anti-HLA-B27 antibody in the serum of 16 of 17 patients who developed reactive arthritis following Yersinia infection.
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D000906:Antibodies / Q000032:analysis*; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D002167:Campylobacter / Q000276:immunology; D003168:Complement Fixation Tests; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D006090:Gram-Negative Bacteria / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D015796:HLA-B27 Antigen; D006801:Humans; D012760:Shigella / Q000276:immunology; D015007:Yersinia / Q000276:immunology
D000906:Antibodies; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes; D006680:HLA Antigens; D015796:HLA-B27 Antigen