Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P.
Rat spinal cord, dorsal root ganglia and skin were investigated employing immunohistochemical technique with specific antisera to neurokinin A and substance P. Neurokinin A-like immunoreactivity was detected in the spinal dorsal horn and skin with a similar distribution pattern as that of substance P-like immunoreactivity. After dorsal root transection a parallel decrease of neurokinin A and substance P-like immunoreactivity was observed in the dorsal horn. Using colchicine pretreatment a population of neurokinin A positive cell bodies was seen in the dorsal root ganglia, and by comparison of consecutive sections of the same cells stained for substance P it was revealed that these neurons also display substance P-like immunoreactivity. However, substance P-, but not neurokinin A-, immunoreactive cells were also observed. It is concluded that neurokinin A- and substance P-like immunoreactivity coexist in a population of rat primary sensory neurons.
C J
CJ
Dalsgaard
A
A
Haegerstrand
E
E
Theodorsson-Norheim
E
E
Brodin
T
T
Hökfelt
D000818:Animals; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism; D006651:Histocytochemistry; D007120:Immunochemistry; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D015288:Neurokinin A; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000293:injuries; D013116:Spinal Cord / Q000378:metabolism; D013373:Substance P / Q000276:immunology / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D013373:Substance P; D015288:Neurokinin A