Contributions of recent research to the classification of spontaneous lymphoid cell neoplasms in mice.
The present review focuses on the mouse as an experimental immunopathologic model for non-Hodgkins' lymphomas and related leukemias. Immunomorphologic evidence will be presented which demonstrates that B and T cell subtypes of mouse lymphoid cell neoplasms resemble and are analogous to B and T cell subtypes of human lymphoid cell neoplasms. The many experimental advantages of the mouse system will be stressed with a particular emphasis on the concept that this newly defined immunomorphologic approach should be effectively combined with biologic, molecular, and cytogenetic parameters.
Pattengale
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PK
Frith
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CH
D000818:Animals; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D005629:Frozen Sections; D006652:Histological Techniques; D006801:Humans; D007938:Leukemia / Q000145:classification* / Q000235:genetics / Q000473:pathology; D008223:Lymphoma / Q000145:classification* / Q000235:genetics / Q000473:pathology; D051379:Mice; D009857:Oncogenes; D013194:Staining and Labeling; D014178:Translocation, Genetic
D004273:DNA, Neoplasm