A mathematical model for vasogenic brain edema.
A two-dimensional model of vasogenic brain edema was constructed using the FEM. The model incorporates the following physical parameters: cerebrovascular hydraulic conductivity, metabolic water production, tissue hydraulic conductivity and compliance, tissue and plasma osmotic and hydrostatic pressures, CSF hydrostatic pressure and absorption, intracerebral stress, and shift of brain tissue. These parameters, related by partial differential equations, were approximated numerically in time and space by the FEM. The results of computer simulation of brain edema by the FEM were compared with experimental data of cold injury brain edema in cats. Computer simulation predicted the observed changes in interstitial pressure, extension of edema, intracerebral stress distribution, and displacement.
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892.
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Nagashima
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B
Horwitz
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Rapoport
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001929:Brain Edema / Q000503:physiopathology*; D002415:Cats; D005110:Extracellular Space / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism; D006801:Humans; D006874:Hydrostatic Pressure; D007427:Intracranial Pressure; D008954:Models, Biological; D009997:Osmotic Pressure; D012212:Rheology