Characteristics of Crimean-Congo hemorrhagic fever virus (Xinjiang strain) in China.
Virus strains isolated from blood of patients during a hemorrhagic fever outbreak in 1968 in southern Xinjiang, China, from Hyalomma asiaticum and from sheep, were found to be identical or closely related to Crimean-Congo hemorrhagic fever (C-CHF) virus by complement fixation and indirect immunofluorescence tests with convalescent sera of patients and with C-CHF reference antibody. The virus was inactivated by ether and acid. Viral synthesis was not suppressed by 5-iododeoxyuridine suggesting an RNA-containing genome. The buoyant density in sucrose was 1.16-1.18 g/cm3. The particle weight was estimated at 3.26 +/- 0.46 X 10(8). The diameter of the virus particles was 85-105 nm.
Yen
Y C
YC
Kong
L X
LX
Lee
L
L
Zhang
Y Q
YQ
Li
F
F
Cai
B J
BJ
Gao
S Y
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D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D002043:Bunyaviridae / Q000145:classification*; D002681:China; D003168:Complement Fixation Tests; D000939:Epitopes; D004986:Ether / Q000494:pharmacology; D006385:Hemagglutination Inhibition Tests; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D006479:Hemorrhagic Fever, Crimean / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007065:Idoxuridine / Q000494:pharmacology; D008970:Molecular Weight
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D004986:Ether; D007065:Idoxuridine