Nimodipine reduces morbidity, mortality after disruption of cerebral blood flow.
Nimodipine is a 1,4 dihydropyridine with Ca++ channel blocking properties. It is more lipophilic than most calcium channel blockers, and thus has a greater volume of distribution within the brain. Many actions of nimodipine have been proposed from work done in animal models following induction of complete or partial cerebral ischemia for varying lengths of time. However, these experimental results have not been sufficiently documented in patient populations, and there exists conflicting data as to nimodipine's mechanism of action in the cerebral ischemic patient. Regardless of the exact mechanisms of action, studies suggest that nimodipine may significantly reduce morbidity and mortality in patients following disruption of cerebral blood flow.
Carmody
J
J
West Virginia School of Medicine, Charleston Division.
Lilly
J K
JK
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D006801:Humans; D009553:Nimodipine / Q000494:pharmacology / Q000627:therapeutic use*
D009553:Nimodipine