[Revascularization of peripheral nerve transplants. Stereomicroangiographic evaluation of revascularization in allogeneic transplants, allogeneic transplants with cyclosporin A therapy and autologous transplants].
Allogeneic nerve grafts of the sciatic nerve longer than 3 cm were transplanted between August- and Wistar rats. One group of animals were treated with 17 mg/kg body weight Cyclosporine A from day 1-28. Autologous nerves served as controls. At various postoperative days contact microangiography, stereoangiography, microdensitometry and histology were performed. Allogeneic untreated grafts were rejected at day 7. Undisturbed neovascularisation was only seen in autografts. In Cyclosporine A treated rats a gradually reduced revascularisation could be observed until day 90.
P
P
Grochowicz
M
M
Schätzle
C
C
Hammer
W
W
Olscewski
W
W
Brendel
D000792:Angiography; D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage*; D006084:Graft Rejection / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D008866:Microsurgery; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D010525:Peripheral Nerves / Q000098:blood supply / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012584:Sciatic Nerve / Q000637:transplantation; D014181:Transplantation Immunology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D003524:Cyclosporins
Revaskularisierung peripherer Nerventransplantate. Stereomikroangiographische Beurteilung der Revaskularisierung bei allogenen Transplantaten, allogenen Transplantaten unter Cyclosporin A-Therapie und autologen Transplantaten.