Immunogenic and antigenic epitopes of immunoglobulins. X: Monoclonal antibodies specific for human IgA, the IgA1 and IgA2 subclasses and an nA2m(2) iso-allotypic epitope.
Monoclonal antibodies (McAb) specific for human IgA, the IgA1 and IgA2 subclasses and the iso-allotypic epitope nA2m(2) have been produced. Three distinct McAb recognize an IgA1-specific epitope expressed in the C alpha 2 domain or the hinge region whilst a further McAb is directed possibly to an IgA1 hinge region epitope. The McAb having nA2m(2) specificity recognizes an iso-allotypic epitope expressed within the Fab region. IgA1 and IgA2 epitopes were detected in gorilla but not rhesus or baboon sera suggesting that the IgA subclasses represent a recent gene duplication even. However, these epitopes were also detected in some non-primate sera.
M A
MA
Farris
D
D
Hardie
G
G
de Lange
R
R
Jefferis
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000096:biosynthesis; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000378:metabolism; D000937:Antigen-Antibody Reactions; D000939:Epitopes / Q000032:analysis* / Q000276:immunology; D006801:Humans; D006825:Hybridomas / Q000378:metabolism; D007070:Immunoglobulin A / Q000032:analysis* / Q000145:classification / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000032:analysis* / Q000145:classification / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments