Lymphocytotoxic antibodies in patients with systemic lupus erythematosus & their household contacts.
Twenty patients with systemic lupus erythematosus (SLE) and their 51 household contacts were screened for the presence of lymphocytotoxic antibodies. A high prevalence of lymphocytotoxic antibodies (LCTAB) was observed in the patients (80% against T cells and 100% against B cells). The antibodies carried specificity for HLA-B5/35 and HLA-DR2/DR3. A high prevalence of LCTAB was also observed in contacts (55% LCTAB-T cells, 88% LCTAB-B cells) with no difference being seen between consanguineous and non-consanguineous male or female relatives.
Department of Medicine, All India Institute of Medical Sciences, New Delhi.
R S
RS
Vasan
N K
NK
Mehra
A N
AN
Malaviya
T K
TK
Chaudhuri
D000328:Adult; D000961:Antilymphocyte Serum / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D005190:Family; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D006680:HLA Antigens