[Adhesion, migration and phagocytic behavior of blood granulocytic neutrophils from the rat and humans in essential hypertension].
Relations between the functions of polymorphonuclear leukocytes (PML) and essential hypertension have been studied. In spite of an increased number in the blood of spontaneously hypertensive rats (SHR) their neutrophils moved for shorter distances than PML of normotensive animals. Neutrophils of hypertensive patients were characterized by a decreased reaction to chemotactic stimulation and an increased adhesion. These alterations of leukocyte functions observed in hypertensive subjects became reversible by treatment of the cells in vitro with verapamil. Therefore, the use of calcium antagonists in the therapy of hypertension could influence the functions of leukocytes favourably.
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I
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Institut für Physiologie, Bereich Medizin, Wilhelm-Pieck-Universität Rostock, DDR.
Baudisch
W
W
Burmeister
J
J
Franz
U
U
D000328:Adult; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology; D007958:Leukocyte Count; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D014700:Verapamil / Q000494:pharmacology
D014700:Verapamil
Adhärenz, Migration und Phagozytoseverhalten neutrophiler Blutgranulozyten der Ratte und des Menschen bei essentieller Hypertonie.