Contact allergy to 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol.
Thirteen patients with contact allergy to phenol-formaldehyde resins (P-F-R) were patch tested with 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol. Nine patients reacted to at least 1 compound, all giving positive test responses to 2,4-dimethylol phenol. Seven patients reacted simultaneously to 2,6-dimethylol phenol while only 1 patient reacted to 3-methylol phenol. Negative test responses were noted in 20 controls. Chemical investigation by high pressure liquid chromatography indicated that the compounds tested were pure and separable. The 3 reported sensitizers may, theoretically, be generated during the manufacture of P-F-R. 2,4-Dimethylol phenol and 2,6-dimethylol phenol have been demonstrated and there has been chromatographic evidence of 3-methylol phenol in the P-F-R used in the routine test series at the department.
M
M
Bruze
E
E
Zimerson
D001592:Benzyl Alcohols / Q000276:immunology*; D001593:Benzyl Compounds / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D009783:Dermatitis, Occupational / Q000276:immunology; D005557:Formaldehyde / Q000276:immunology; D006801:Humans; D010328:Patch Tests; D010636:Phenols / Q000276:immunology; D011108:Polymers / Q000276:immunology
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D010636:Phenols; D011108:Polymers; D005557:Formaldehyde; C047965:2,6-dimethylol phenol; C011276:3-hydroxybenzyl alcohol; C011529:phenol-formaldehyde resin; C047966:2,4-dimethylol phenol