Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.
A 23-year-old woman with metastatic Sertoli-Leydig cell tumor was treated with cisplatin, vinblastine, and bleomycin. Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found. Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of microangiopathic hemolytic anemia and thrombocytopenia. Renal insufficiency, however, persisted.
van der Meer
J
J
de Vries
E G
EG
Vriesendorp
R
R
Willemse
P H
PH
Donker
A J
AJ
Aalders
J G
JG
D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010386:Pelvic Neoplasms / Q000556:secondary; D012707:Sertoli Cell Tumor / Q000188:drug therapy; D013577:Syndrome; D014511:Uremia / Q000139:chemically induced* / Q000188:drug therapy; D014747:Vinblastine / Q000009:adverse effects
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin