Single channel currents in mouse embryonal multipotential carcinoma cells.
Electrical membrane properties of embryonal non-differentiated carcinoma cells which have been extensively used for the study of early mammalian embryogenesis were investigated by using patch clamp techniques. These multipotential cells were found to contain a restricted repertoire of a small number of ionic channels on the whole cell membrane. The most abundant type was a voltage- and calcium-activated potassium channel with characteristics similar to those described in fully differentiated cells.
Simonneau
M
M
Eddé
B
B
Nicolas
J F
JF
Jakob
H
H
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002454:Cell Differentiation; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D051379:Mice; D011188:Potassium / Q000378:metabolism; D013724:Teratoma / Q000378:metabolism* / Q000473:pathology
D002712:Chlorides; D007473:Ion Channels; D011188:Potassium; D002118:Calcium