Study of enzyme inhibitory activities by dipyridamole.
Inhibitory activities of Dipyridamole (DPM, 2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)py rim idine) against xanthine oxidase (XO), carbonic anhydorase (CA) and monoamine oxidase (MAO) were studied, in vitro. DPM did not inhibit XO and CA, but it strongly inhibited MAO. The type of inhibition by DPM against MAO with respect to benzylamine as a substrate was uncompetitive.
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
T
T
Noro
M
M
Ehara
A
A
Ueno
D002257:Carbonic Anhydrase Inhibitors; D004176:Dipyridamole / Q000494:pharmacology*; D004791:Enzyme Inhibitors; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D002257:Carbonic Anhydrase Inhibitors; D004791:Enzyme Inhibitors; D008996:Monoamine Oxidase Inhibitors; D004176:Dipyridamole; D014969:Xanthine Oxidase