Expression of c-myc oncogene during differentiation of human burst-forming unit, erythroid (BFU-E).
We investigated the serial expression of c-myc oncogene during differentiation of normal human burst-forming unit, erythroid (BFU-E), in vitro, together with the replating efficiency and the expression of transferrin receptors. We found that the c-myc oncogene was expressed in the early progeny of BFU-E and that this expression decreased during erythroid differentiation. This change of the c-myc expression was well correlated to changes in the replating efficiency and the expression of transferrin receptors. These observations indicate that the c-myc oncogene probably has a physiological role in normal human hematopoiesis as well as leukemic hematopoiesis.
Umemura
T
T
Umene
K
K
Nishimura
J
J
Fukumaki
Y
Y
Sakaki
Y
Y
Ibayashi
H
H
D002454:Cell Differentiation; D002455:Cell Division; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics; D006410:Hematopoiesis; D006801:Humans; D066298:In Vitro Techniques; D009857:Oncogenes; D012313:RNA / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics*; D011990:Receptors, Transferrin
D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D012313:RNA; D005914:Globins