Angiotensin-induced hypertension and chemotherapy for multiple lesions of malignant melanoma.
By continuous infusion of angiotensin II, a marked increase in blood flow can be induced in tumour tissues, with no increase in normal tissues. This functional characteristic of tumour blood vessels, i.e., lack of autoregulation, has been utilized as an aid to chemotherapy by selectively enhancing drug delivery to tumour tissues. We describe our results in seven patients with malignant melanoma.
H
H
Takematsu
Y
Y
Tomita
T
T
Kato
D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D001783:Blood Flow Velocity / Q000187:drug effects; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000098:blood supply* / Q000188:drug therapy; D008875:Middle Aged; D017663:Peplomycin; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D000804:Angiotensin II; D017663:Peplomycin; D014750:Vincristine; D003606:Dacarbazine