[Effect of verapamil on the molecular characteristics of myocardial actomyosin in experimental ischemia].
Verapamil was shown to be able to recover a significantly depressed actomyosin ATPase activity of the unaffected left ventricular area in experimental myocardial ischemia. The drug also increased Ca-sensitivity of the ATPase reaction, with the amount of actomyosin components (Tn-1, LCM-1, LCM-2, Tn-C) almost reaching the control level. The possibility of direct interaction of verapamil with Ca-binding sites on actomyosin macromolecule is suggested. Its influence on metabolism and gene expression is not excluded.
M A
MA
Kaĭfadzhian
E G
EG
Dzhanpoladian
T S
TS
Zaminian
V M
VM
Samvelian
S S
SS
Oganesian
D000205:Actomyosin / Q000378:metabolism*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003327:Coronary Disease / Q000378:metabolism* / Q000517:prevention & control; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D007473:Ion Channels; D000205:Actomyosin; D014700:Verapamil; D017301:Ca(2+) Mg(2+)-ATPase; D002118:Calcium
Vliianie verapamila na molekuliarnuiu kharakteristiku aktomiozina miokarda pri éksperimental'noĭ ishemii.