Failure of Verapamil in inhibiting allergen-induced histamine release in vivo.
In order to evaluate the effect of Verapamil on human cutaneous anaphylactic responses, ragweed-sensitive individuals were skin tested with ragweed, ragweed plus Verapamil, and Verapamil alone. In addition, using a skin chamber technique, the effect of Verapamil on antigen-induced histamine release in vivo was investigated. The results suggest that Verapamil, applied locally in non-irritant doses, does not affect Type I hypersensitivity skin reactions.
Ting
S
S
Mansfield
L E
LE
Rauls
D O
DO
D000485:Allergens / Q000276:immunology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D000485:Allergens; D014700:Verapamil