Double dissociation between perseveration in memory and problem solving tasks.
This study reports a double dissociation between perseverative responses on a short-term verbal memory test and a card sorting task, as shown by two patients with cerebral tumours. The two patients were matched for number of correct responses on the memory task. The first patient, with a craniopharyngioma and associated dilatation of the third ventricle and lateral ventricles, showed perseveration on the short-term memory task but not on the card sorting task. The second patient, with a subfrontal tumour involving the anterior corpus callosum, perseverated on the card sorting task but not on the short-term memory task. The presence of this double dissociation demonstrates the functional specificity of perseveration in certain memory and problem solving contexts and suggests that distinct subcortical/frontal mechanisms may underly specific types of perseveration.
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Kapur
D000647:Amnesia / Q000523:psychology; D001037:Aphasia / Q000523:psychology*; D001254:Astrocytoma / Q000523:psychology; D001932:Brain Neoplasms / Q000523:psychology; D003337:Corpus Callosum / Q000503:physiopathology; D003397:Craniopharyngioma / Q000523:psychology; D004193:Discrimination Learning / Q000502:physiology; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008570:Memory, Short-Term / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010911:Pituitary Neoplasms / Q000523:psychology; D011340:Problem Solving / Q000502:physiology; D014057:Tomography, X-Ray Computed