Interaction of myelin basic protein with gangliosides and ganglioside-phospholipid mixtures.
The interaction of myelin basic protein with monosialoganglioside GM1 was investigated. It was found that the emission maximum of the tryptophan of the protein is blue-shifted due to the interaction. In mixtures of the monosialoganglioside with phosphatidylcholine, the myelin basic protein induces phase separation of the lipids as inferred from differential scanning calorimetry experiments.
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D000818:Animals; D002152:Calorimetry, Differential Scanning; D005677:G(M1) Ganglioside / Q000378:metabolism; D005732:Gangliosides / Q000378:metabolism*; D008433:Mathematics; D004676:Myelin Basic Protein / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011485:Protein Binding; D013050:Spectrometry, Fluorescence; D013552:Swine; D014364:Tryptophan / Q000032:analysis
D005732:Gangliosides; D004676:Myelin Basic Protein; D010743:Phospholipids; D005677:G(M1) Ganglioside; D014364:Tryptophan