[Treatment of aggressive non-Hodgkin's lymphoma in aged patients with a combination of methyl-GAG, etoposide and prednimustine].
The authors report the results of a chemotherapy regimen of methyl-GAG, etoposide and prednimustine in 21 elderly patients (median age = 78 years) with aggressive non-Hodgkin's lymphoma. Sixteen patients responded (11 complete remissions, 5 partial remissions) with minor toxic side-effects. This regimen could be proposed for patients whose age and/or cardiovascular status prohibit treatment with usual anthracycline-containing chemotherapy programs.
Service d'hématologie clinique, hôpital Beaujon, Clichy, France.
P
P
Solal-Celigny
G
G
Tertian
A
A
Herrera
N
N
Brousse
M
M
Peuchmaur
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008935:Mitoguazone / Q000008:administration & dosage; D011238:Prednimustine / Q000008:administration & dosage; D015996:Survival Rate
D005047:Etoposide; D011238:Prednimustine; D008935:Mitoguazone
Traitement des lymphomes non hodgkiniens agressifs du sujet âgé par association de méthyl-GAG, étoposide, prednimustine.