[High blood triiodothyronine and the euthyroid state].
A high excess of circulating T3 was observed in an euthyroid woman. Agarose gel electrophoresis of serum preincubated with 125I-T3 revealed an abnormal T3-binding in gamma-globulin zone. This binding interfered with the hormone radioimmunoassay. Immunological characterization identified this protein as an IgG-K and IgG-lambda polyclonal antibody that bound T3 but not T4. Scatchard analysis of 125I-T3 binding to the gamma-globulin fraction isolated showed a single class of binding sites with a high affinity Ka = 0.4 X 10(9) L/M and maximal binding capacity of 5.2 X 10(-9) M.
A
A
Brisson-Lougarre
M
M
Abbal
M
M
Hoff
C J
CJ
Blum
D000368:Aged; D000906:Antibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D014284:Triiodothyronine / Q000097:blood* / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D007074:Immunoglobulin G; D005719:gamma-Globulins; D014284:Triiodothyronine
Hypertriiodothyroninémie et euthyroide.