[Improved intraoperative leak control in cytostatic drug isolation perfusion of tumors of the extremities].
The success of extremity perfusion and the protection from systemic side effects largely depend upon the prevention of systemic drug leakage from the extremity circulation. The use of autologous 111-Indium labelled erythrocytes for leakage control allows a continuous exact surveillance and timely correction of the tourniquet position in case a major leak should occur. A total of 97 patients were studied. In 6 patients (= 6%) the perfusion had to be discontinued within the first 30 min due to an uncorrectable leak of greater than 20%. In 31 patients (= 32%), a major leak could be reduced by manipulation of the tourniquet. No systemic side-effects could be observed in any of our patients. Applying leakage control by means of 111-Indium labelled erythrocytes extremity perfusion has proved to be a safe procedure in patients with high risk or recurrent malignant melanoma and soft tissue sarcoma.
Sektion Chirurgische Onkologie, Chirurgischen Universitätsklinik, Heidelberg.
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Sinn
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Bubeck
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Kettelhack
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001132:Arm / Q000000981:diagnostic imaging; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004912:Erythrocytes; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D007205:Indium Radioisotopes; D007866:Leg / Q000000981:diagnostic imaging; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011877:Radionuclide Imaging; D012509:Sarcoma / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*
D007205:Indium Radioisotopes; D002945:Cisplatin; D008558:Melphalan
Verbesserte intraoperative Leckkontrolle bei der isolierten Zytostatikaperfusion von Extremitätentumoren.