[Electron microscopic characteristics of carcinoid tumors of varying localization and degree of differentiation].
Results of an electron-microscopic study of 15 carcinoid tumours of different sites were compared to those of histological and histochemical investigation. Highly differentiated tumours (6 observation had pronounced tissue and organ-specific features, contained a high number of argentaffin and/or argyrophilic endocrine granules in all cells. Moderately differentiated tumours (3 observations) showed a typical structure and abundance of secretory granules in the cytoplasm; when the chromatin of their nuclei became coarse, consisting of large clumps, karyolemma invaginations and bulging appeared, this being a sign of malignization. These nuclei changes progressed in the poorly differentiated tumours, number of secretory granules decreased (they were absent in 50% of cells). Argentaffin carcinoid of the appendix, intestine and cecum contained mainly serotonin granules (diameter 200-350 nm) and small number of polypeptide hormones granules (diameter less than 200 nm). The inverse correlation between the granules was observed in the bronchial carcinoid.
Derizhanova
I S
IS
Reznikova
G L
GL
D001063:Appendiceal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D001984:Bronchial Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D002276:Carcinoid Tumor / Q000378:metabolism / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D007421:Intestine, Small; D008854:Microscopy, Electron; D013194:Staining and Labeling / Q000379:methods; D013953:Thymus Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
Elektronno-mikroskopicheskaia kharakteristika kartsinoidnykh opukholeĭ razlichnoĭ lokalizatsii i stepeni differentsirovki.