Turnover of alpha-2-antiplasmin in patients with acute promyelocytic leukemia.
Patients with acute promyelocytic leukemia have a bleeding disorder which was thus far explained by a coagulopathy based on diffuse intravascular coagulation (DIC). We observed severe alpha-2-antiplasmin deficiency in a consecutive series of such patients. We postulate proteolysis rather than DIC, also because of increased turnover of 125I-alpha-2-antiplasmin, to be responsible for the coagulopathy. Alpha-2-antiplasmin deficiency may well contribute to the bleeding disorder in acute promyelocytic leukemia.
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LH
Kahle
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Avvisati
R J
RJ
Lamping
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Moretti
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Mandelli
J W
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ten Cate
D000990:Antithrombin III / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy; D010958:Plasminogen / Q000032:analysis; D010976:Platelet Count; D012016:Reference Values; D000979:alpha-2-Antiplasmin / Q000172:deficiency / Q000378:metabolism*
D001779:Blood Coagulation Factors; D000979:alpha-2-Antiplasmin; D000990:Antithrombin III; D010958:Plasminogen