[Circulating interferon in patients with systemic lupus erythematosus. A prospective study].
The serum levels of interferon (IFN) were measured in 31 patients with systemic lupus erythematosus (SLE). Among the 31 patients, 8 (25%) showed IFN in the sera: in 4 patients IFN titers of 16 U/ml, and in the other 4 patients titers of greater than or equal to 32 U/ml became detectable. Whereas antibodies to native DNA (nDNA) were present in 6 of the 8 IFN positive patients, anti-nDNA antibodies were only positive in 6 of the 23 IFN negative individuals (p less than 0.002). Eight months after the first search for IFN in the patients' sera, 6 of the 8 IFN positive patients showed reduced IFN serum levels and one each had an increased or stable IFN titer. A good correlation between IFN titers and both the anti-nDNA antibody titers and the disease activity was observed. However, there were patients with active disease, high anti-nDNA titers but no IFN in the serum.
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Dudli
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Kaiser
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Aguet
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Joller
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Pichler
P J
PJ
Grob
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Fontana
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002478:Cells, Cultured; D002648:Child; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D007372:Interferons / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D003176:Complement C3; D003181:Complement C4; D004247:DNA; D007372:Interferons
Zirkulierendes Interferon bei Patienten mit systemischem Lupus erythematodes. Eine prospektive Studie.