A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.
Protein-tyrosine kinases are implicated in the control of normal and neoplastic cell growth. We have used molecular cloning strategies to characterize a lymphocyte-specific protein-tyrosine kinase gene distinct from but closely related to src and yes. This gene, encoded by a genetic locus defined here as lskT, is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Thus alterations in the structure or expression of this protein-tyrosine kinase gene may in some cases mediate neoplastic transformation. In addition, transcription of the normal lskT gene is restricted to cells of lymphoid origin. We infer that the lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes.
Marth
J D
JD
Peet
R
R
Krebs
E G
EG
Perlmutter
R M
RM
D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004247:DNA; D004273:DNA, Neoplasm / Q000032:analysis; D005786:Gene Expression Regulation; D005796:Genes; D008214:Lymphocytes / Q000201:enzymology*; D008221:Lymphoid Tissue / Q000201:enzymology; D008223:Lymphoma / Q000201:enzymology / Q000235:genetics*; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D011061:Poly A / Q000032:analysis; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016392:Proto-Oncogene Proteins pp60(c-src); D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D012191:Retroviridae Proteins / Q000235:genetics; D015682:Retroviridae Proteins, Oncogenic; D012689:Sequence Homology, Nucleic Acid
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011994:Recombinant Proteins; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; D011061:Poly A; D004247:DNA; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)