Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis.
The susceptibility of the skin to various irritants was investigated with the aim of determining the role of the barrier function of the stratum corneum, skin dryness and whether a history of atopic dermatitis (AD) was a factor. The transepidermal water loss (TEWL) was measured using an evaporimeter and skin hydration using a Corneometer and by visual scoring. The group with a history of AD (n = 20) had a lower pre-exposure barrier function and a higher TEWL value following irritant exposure than the group with a history of allergic contact dermatitis (n = 18) and a control group (n = 18). Clinically dry skin was more susceptible than normal skin, though no difference was noted in the pre-exposure barrier function. The increased susceptibility to irritants in those with a past history of AD was probably due to impaired barrier function and/or the presence of a dry skin.
Tupker
R A
RA
Department of Dermatology, State University Hospital, Groningen, The Netherlands.
Pinnagoda
J
J
Coenraads
P J
PJ
Nater
J P
JP
D000293:Adolescent; D000328:Adult; D003876:Dermatitis, Atopic / Q000503:physiopathology*; D003877:Dermatitis, Contact / Q000503:physiopathology; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000503:physiopathology*; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000503:physiopathology; D012967:Sodium Dodecyl Sulfate; D013997:Time Factors; D014870:Water Loss, Insensible / Q000187:drug effects
D007509:Irritants; D012967:Sodium Dodecyl Sulfate