Effect of changes in dietary sodium and potassium on blood pressure and cellular electrolyte handling in young normotensive subjects.
In a study on 22 normotensive male subjects, a change in dietary sodium intake from 29.6 +/- 6.0 to 332.5 +/- 13.9 mmol/day (mean +/- s.e.m.), over 7 days, was associated with a significant rise in supine and standing systolic blood pressure and a fall in sodium pump activity. Intracellular sodium remained constant, while intracellular potassium fell. These changes appeared to be reversed by the addition of potassium (96 mmol/day) to the high sodium diet. The 12 subjects with a family history of essential hypertension, as determined by measurement of parental blood pressure, did not differ in their response from those whose parents were normotensive.
Weissberg
P L
PL
West
M J
MJ
Kendall
M J
MJ
Ingram
M
M
Woods
K L
KL
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D007424:Intracellular Fluid / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000008:administration & dosage* / Q000378:metabolism; D012964:Sodium / Q000008:administration & dosage* / Q000378:metabolism; D014882:Water-Electrolyte Balance
D007473:Ion Channels; D012964:Sodium; D011188:Potassium