Dextran and antidextran antibodies in the sera of patients with liver diseases.
Dextran and antidextran antibodies were examined by enzyme immunoassay (EIA) and immunodiffusion in sera of 108 patients with various liver diseases. In EIA, IgG class antidextran antibody was detected in 16 patients (14.8%), mostly with chronic liver diseases such as liver cirrhosis (26.9%) and chronic hepatitis (22.2%). IgM class antibody was detected in 10 patients (9.2%). Results obtained by EIA inhibition revealed that dextran antigen was present mostly in sera of patients with acute liver diseases such as fulminant hepatitis (75.0%) and acute hepatitis (17.2%). Identity of the dextran antigen in the liver diseases serum and the dextran preparation recognized by an antibody-containing serum was demonstrated. These results suggest that the damaged hepatocytes in the process of the liver disease may release the dextran antigen into the patient's circulation which is responsible for the formation of antidextran antibodies by the patients with liver diseases.
T
T
Morito
T
T
Nishimaki
K
K
Saito
H
H
Yoshida
R
R
Kasukawa
K
K
Kano
D000208:Acute Disease; D000906:Antibodies / Q000032:analysis*; D002908:Chronic Disease; D003911:Dextrans / Q000032:analysis*; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008107:Liver Diseases / Q000276:immunology*
D000906:Antibodies; D003911:Dextrans; D007074:Immunoglobulin G; D007075:Immunoglobulin M