[Effect of the stable prostacyclin analog (iloprost) on survival of ischemically-stressed swine kidney transplants].
Kidneys of 5 pigs were pretreated in situ with Iloprost (Fa. Schering) (0.5 micrograms X kg-1 X min-1) and exposed to a warm ischaemia time of 45 minutes. The perfusion behaviour of these kidneys during the initial fall current perfusion and hypothermic machine perfusion for 24 hours was to be compared with that of kidneys with a warm ischaemia time of less than 5 minutes. After retransplantation in all kidneys a good blood supply and an immediate urine production was to be seen for the duration of the experiment of 3 hours.
Langkopf
B
B
Rebmann
U
U
Schabel
J
J
Pauer
H D
HD
Heynemann
H
H
Förster
W
W
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D016285:Iloprost; D016030:Kidney Transplantation; D009926:Organ Preservation; D012079:Renal Circulation / Q000187:drug effects; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
D002317:Cardiovascular Agents; D011464:Epoprostenol; D016285:Iloprost
Einfluss eines stabilen Prostazyklin-Analogons (Iloprost) auf die Konservierung ischämisch-belasteter Schweinenierentransplantate.