Decreased major urinary protein in male Bar Harbor 129 REJ dystrophic mice indicates a hormonal deficiency.
A significant decrease in major urinary protein (MUP) in adult male Bar Harbor 129REJ dystrophic mice correlated with a marked decrease in the amount of translatable MUPmRNA in the liver. Previous investigations have shown that MUP synthesis is under complex multihormonal regulation suggesting that the dystrophic mouse may have a hormonal deficiency.
Department of Genetics, University of Edinburgh, Scotland, U.K.
H A
HA
John
I F
IF
Purdom
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006728:Hormones / Q000172:deficiency*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009137:Muscular Dystrophy, Animal / Q000652:urine*; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis
D006728:Hormones; D011506:Proteins; D012333:RNA, Messenger; C035737:major urinary proteins