Antibody reactivity against trophoblast and trophoblast products.
Sensitive immunoassays have been applied to WHO reference bank sera from fertile and infertile women in order to assess any naturally occurring antibody reactive with isolated human placental trophoblast membranes or two separate trophoblast protein products (hCG and SP1). A very low incidence of antibody reactive with solubilised trophoblast membrane was detected, and no significant antibody to either hCG or SP1 could be detected. Infertile states represented within this serum bank appear unlikely to involve adverse immune reactions to trophoblast.
Johnson
P M
PM
Cheng
H M
HM
Stevens
V C
VC
Matangkasombut
P
P
D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D006063:Chorionic Gonadotropin / Q000276:immunology* / Q000378:metabolism; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D010920:Placenta / Q000166:cytology* / Q000276:immunology; D011257:Pregnancy Proteins / Q000276:immunology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000276:immunology*; D014327:Trophoblasts / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014944:World Health Organization
D000906:Antibodies; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins