[Arterial thromboses and essential thrombocythemia in young patients].
The authors report two cases of essential thrombocythemia (ET) which occurred in young subjects (25 and 33 years) and revealed by arterial thromboses. The first case was one of myocardial infarction: in the second case, ischemic signs in the left leg led to cutaneous necrosis. Thrombotic signs are commonplace in ET and are generally considered to be attributable to an impaired underlying vascular territory. The cases reported by the authors conflict with these data and it would seem, therefore, that the onset of thrombosis in the absence of any associated cardiovascular risk can be envisaged. With regard to therapy, if thrombotic signs occur, myelosuppressive treatment must be undertaken; in asymptomatic patients, due to the potential and unpredictable risk of thrombosis, this treatment should be initiated if the platelet count rises above 800 x 10(9)/l. Hydroxyurea is generally prescribed (particularly in young patients) since it is generally considered to be devoid of any leukemogenic potential.
Decoulx
E
E
Service de Cardiologie C, Hôpital Cardiologique, CHU, Lille.
Millaire
A
A
Jude
B
B
Marquand
A
A
Tison
E
E
Bauters
F
F
Ducloux
G
G
D000328:Adult; D001158:Arteries; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000188:drug therapy; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology*
Thromboses artérielles et thrombocytémie essentielle chez le sujet jeune.