Mitoxantrone: potential for use in intensive therapy.
Mitoxantrone is a synthetic anthraquinone that is active in the therapy of a number of malignancies. At standard doses, toxicity has been primarily myelosuppressive with little extramedullary toxicity. These features in conjunction with evidence that mitoxantrone displays a dose-response effect in vitro make it an attractive candidate for intensive therapy regimens. The data to support the development of mitoxantrone for intensive programs and the clinical evidence that it can be substantially dose escalated are reviewed.
University of Texas, M.D. Anderson Cancer Center, Department of Hematology, Houston, TX 77030.
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LeMaistre
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D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*
D008942:Mitoxantrone