[Correction with formate of metabolic disorders in alcoholic intoxication].
Formate was studied for its effect on the content of acetaldehyde, activity of the total aldehyde dehydrogenase, content of substrates of glycolysis and tricarbonic-cycle and pool of free amino acids of rat tissues during alcohol intoxication. The introduction of formate during the acute alcohol intoxication lowers the acetaldehyde content in the blood; the ethanol load being prolonged--it increases the activity of aldehyde dehydrogenase and normalizes the content of pyruvate, glutamate and malate in the liver and glutamate and oxaloacetate in the brain, that evidences for the correction of metabolic disturbances in the organism.
Gulyĭ
M F
MF
Stogniĭ
N A
NA
Silonova
N V
NV
Shevtsova
N F
NF
Solodova
E V
EV
D000079:Acetaldehyde / Q000097:blood; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005561:Formates / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats
D000596:Amino Acids; D005561:Formates; C030544:formic acid; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde
Korrektsiia formiiatom metabolicheskikh narusheniĭ pri alkogol'noĭ intoksikatsii.