Indoleacetic acid-induced hypothermia and changes in serotonin metabolism in mice.
The effects of the tryptamine metabolite, indoleacetic acid (IAA) on body temperature and serotonin (5-HT) metabolism in mice were investigated. IAA at 300 mg/kg i.p. induced significant hypothermia in mice. It caused a remarkable decrease in concentration of total tryptophan (TRP) and a considerable increase in free TRP in serum. IAA increased 5-HT, 5-hydroxyindoleacetic acid and TRP in the brain, but decreased 5-HT synthesis in the brain. The 5-HT antagonist, methysergide and the 5-HT depleter, p-chlorophenylalanine did not affect IAA-induced hypothermia.
Yamada
J
J
Sugimoto
Y
Y
Horisaka
K
K
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001923:Brain Chemistry; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007210:Indoleacetic Acids / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
D007210:Indoleacetic Acids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C030737:indoleacetic acid; D010134:Fenclonine