Examination of the ouabain-sensitive Na-K pump in essential hypertensive children of normal body weight.
The ouabain-sensitive Na-K pump of erythrocytes was examined in 17 normotensive and 15 essential hypertensive children aged 6-16 years. Children who proved to be fat according to skinfold measurements were excluded from the examinations. The activity of the ouabain-sensitive Na-K pump was assessed by measuring the ratio of Na-ion efflux and K-ion influx through the erythrocyte membrane previously treated with para-chloro-mercury benzol sulphonate. In essential hypertensive children the ratio of the Na/K fluxes was found to be characteristically 5.8 +/- 2.0, showing a mathematically significantly more active (p less than 0.05) Na-K pump function than in the control group 9.6 +/- 5.8. According to the results, however, the method is suitable only for the separation of groups and not of individuals.
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Koltai
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Aranyi
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Czinner
D000293:Adolescent; D001794:Blood Pressure; D001835:Body Weight; D002648:Child; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D012964:Sodium / Q000097:blood / Q000378:metabolism*
D007473:Ion Channels; D010042:Ouabain; D012964:Sodium; D011188:Potassium