Pancreatic amylase, plasma glucose, and insulin responses to propionate or monensin in sheep.
Yearling wethers fitted with reentrant bile-pancreatic duct cannulae were in a two-part study of effects of duodenal propionate infusions or increased ruminal propionate caused by dietary monensin on pancreatic alpha-amylase secretion and glucose and insulin in blood plasma. Continuous duodenal infusion of propionate increased concentrations of glucose and insulin in blood plasma of wethers fed alfalfa. Results supported a direct response of insulin secretion to propionate. Amylase secretion was not affected. Addition of monensin (22 ppm) to an 80% corn diet reduced the ratio of acetate:propionate in rumen, but bile-pancreatic flow and amylase activity were unaffected. Monensin supplementation had little influence on glucose and insulin in blood plasma. Pancreatic alpha-amylase secretion of ruminants seems to be a complex phenomenon that is not regulated strictly by fluctuations of glucose or insulin.
Johnson
D D
DD
Mitchell
G E
GE
Tucker
R E
RE
Muntifering
R B
RB
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005663:Furans / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D008297:Male; D008985:Monensin / Q000494:pharmacology*; D009919:Orchiectomy; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D011422:Propionates / Q000494:pharmacology*; D012756:Sheep
D001786:Blood Glucose; D005663:Furans; D007328:Insulin; D011422:Propionates; D008985:Monensin; D000681:Amylases