[Participation of Ca-dependent systems in thrombocyte aggregation induced by the action of staphylococcal toxin and ADP].
The mechanism of ADP and staphylococcal toxin effect on the platelet aggregation has been studied on the rabbit's platelet-rich plasma. Ca2+-channels blockade of the cell membrane by verapamil resulted in considerable inhibition of aggregation induced by ADP and some weakening of toxin action. Binding of extracellular calcium EDTA inhibited sharply or blocked the aggregation of both inductors. It has been concluded that Ca2+ transport into cell is necessary chain in ADP and staphylococcal toxin effect but under the action of toxin transport Ca2+ into platelet is brought through a verapamil-resistant Ca2+-channels forming in the membrane under the interaction with toxin.
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D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D004492:Edetic Acid / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013210:Staphylococcus; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D001427:Bacterial Toxins; D007473:Ion Channels; D000244:Adenosine Diphosphate; D004492:Edetic Acid; D014700:Verapamil; D002118:Calcium
Ob uchastii Ca-zavisimykh sistem v agregatsii trombotsitov, vyzvannoĭ deĭstviem stafilokokkovogo toksina i ADF.