Mallory body formation and amyloid deposition in the liver of aged mice fed a vitamin A deficient diet for a prolonged period.
When twenty Swiss albino mice (male) were fed a vitamin A deficient diet for 18-24 months, Mallory bodies (MB(s] were observed. MBs were found by light microscopy and electron microscopy in the hepatocytes of six mice fed the vitamin A deficient diet and in one of the 15 control mice. Coincidentally, amyloid deposits were found in the space of Disse in the livers of 8 mice fed the deficient diet (three of the six mice with MBs). Amyloid was seen in two control mice suggesting that vitamin A enhanced amyloid deposition and MB formation in aging mice which spontaneously form amyloid and MBs. The possible role of vitamin A deficiency in the pathogenesis of MB formation is briefly discussed.
Akeda
S
S
Fujita
K
K
Kosaka
Y
Y
French
S W
SW
D000375:Aging; D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006818:Hyalin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D013997:Time Factors; D014802:Vitamin A Deficiency / Q000378:metabolism*
D000682:Amyloid