Lack of immunological analogy between the beta-subunits of cholera toxin and human choriogonadotropin.
A chemical relatedness has been described between the beta-subunit of cholera toxin and that of the four dimeric glycoprotein hormones (hCG, hLH, hFSH and hTSH). However, antibodies induced by cholera toxin did not crossreact, when tested by labeled hCG binding and immunocytochemistry, with the beta-subunit of hCG. It appears that differences in the tertiary structures, as shown in this study, account for distinct epitopes. Similarities in biological activity between these two compounds, such as induction of adenyl cyclase or a protective effect against some tumors, are not based on immunological mechanisms.
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D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D002772:Cholera Toxin / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D007106:Immune Sera; D010446:Peptide Fragments; D002772:Cholera Toxin; D000262:Adenylyl Cyclases