Drug level monitoring: cytostatics.
The present review on the quantification of cytostatic drugs has mainly been focussed on chromatographic techniques. Special attention has been paid to the precautions that have to be taken into account to ensure the selectivity and accuracy of the various methods. The various cytostatics that have been dealt with are: alkylating agents, antimetabolites, vinca alkaloids, antibiotics, cis-diamminedichloroplatinum, podophyllotoxine derivatives, and nitrosoureas.
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Eksborg
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Ehrsson
D000477:Alkylating Agents / Q000097:blood; D000609:Aminoacridines / Q000097:blood; D000677:Amsacrine; D000880:Anthraquinones / Q000097:blood; D000903:Antibiotics, Antineoplastic / Q000097:blood; D000963:Antimetabolites / Q000097:blood; D000970:Antineoplastic Agents / Q000097:blood*; D001761:Bleomycin / Q000097:blood; D002066:Busulfan / Q000097:blood; D002699:Chlorambucil / Q000097:blood; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D002945:Cisplatin / Q000097:blood; D003520:Cyclophosphamide / Q000097:blood; D003561:Cytarabine / Q000097:blood; D005472:Fluorouracil / Q000097:blood; D006801:Humans; D013058:Mass Spectrometry; D008558:Melphalan / Q000097:blood; D008727:Methotrexate / Q000097:blood; D008937:Mitomycins / Q000097:blood; D008991:Monitoring, Physiologic; D009607:Nitrosourea Compounds / Q000097:blood; D011034:Podophyllotoxin / Q000097:blood; D011687:Purines / Q000037:antagonists & inhibitors; D013852:Thiotepa / Q000097:blood; D014748:Vinca Alkaloids / Q000097:blood
D000477:Alkylating Agents; D000609:Aminoacridines; D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D000963:Antimetabolites; D000970:Antineoplastic Agents; D008937:Mitomycins; D009607:Nitrosourea Compounds; D011687:Purines; D014748:Vinca Alkaloids; D000677:Amsacrine; D003561:Cytarabine; D001761:Bleomycin; D002699:Chlorambucil; D003520:Cyclophosphamide; D013852:Thiotepa; D002066:Busulfan; D011034:Podophyllotoxin; D002945:Cisplatin; D008558:Melphalan; D005472:Fluorouracil; D008727:Methotrexate