[The mechanism of the interaction of the pH-dependent cytostatic cauloside C with the membranes of tumor cells and liposomes].
The effect of the medium pH on accumulation of [3H]-cauloside C by tumor cells, its intracellular localization, and interaction of the glicoside with membranes of tumor cells and liposomes has been studied. The shift towards weakly acids pH leads to the increase in the amount of cauloside C accumulated by tumor cells and changes the pattern of interaction of cauloside C with the membranes.
Prokof'eva
N G
NG
Likhatskaia
G N
GN
Aminin
D L
DL
Gafurov
Iu M
IuM
Sasunkevich
V A
VA
Strigina
L I
LI
Anisimov
M M
MM
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002151:Calorimetry; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002458:Cell Fractionation; D002462:Cell Membrane / Q000378:metabolism*; D004347:Drug Interactions; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000493:pharmacokinetics*; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D012502:Sapogenins; D014783:Viscosity
D000970:Antineoplastic Agents; D008081:Liposomes; D012502:Sapogenins; D009828:Oleanolic Acid; C018245:cauloside C
Mekhanizm vzaimodeĭstviia pH-zavisimogo tsitostatika kaulozida C s memranami opukholevykh kletok i liposom.