DNA restriction polymorphism of alpha-fetoprotein gene after digestion by MspI endonuclease.
Hybridization of alpha-fetoprotein clones cDNA with human DNAs digested by seven restriction endonucleases reveals one polymorphism. This polymorphism, detected after restriction by MspI, is at low frequency (f = 0.02) and is validated by family analysis. It corresponds to an intronic sequence, for a methylated site external to the probes utilized.
Lavareda de Souza
S
S
Frain
M
M
Rahuel
C
C
Sala-Trépat
J M
JM
Lucotte
G
G
D004262:DNA Restriction Enzymes; D006801:Humans; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics*
D000509:alpha-Fetoproteins; D004262:DNA Restriction Enzymes