C-myc expression is reduced in antipain-treated proliferating C3H 10T1/2 cells.
In this report, we demonstrate that treatment of proliferating irradiated and nonirradiated C3H 10T1/2 cells with the protease inhibitor antipain is associated with a reduction in c-myc expression. Under conditions in which antipain treatment results in reduced c-myc transcripts, there is no effect on total RNA synthesis, growth rate, or saturation density. Antipain may be a useful inhibitor in which to further study the role of c-myc in cellular physiology.
Chang
J D
JD
Billings
P C
PC
Kennedy
A R
AR
D000818:Animals; D000976:Antipain / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D051379:Mice; D008809:Mice, Inbred C3H; D009693:Nucleic Acid Hybridization; D009842:Oligopeptides / Q000494:pharmacology*; D009857:Oncogenes / Q000187:drug effects*; D012313:RNA / Q000096:biosynthesis; D014529:Uridine / Q000378:metabolism
D009842:Oligopeptides; D000976:Antipain; D012313:RNA; D014529:Uridine