[Comparative histological studies of germinative tissue after chemotherapy or radiation therapy in patients with malignant testicular tumors].
Described in this paper are morphological and morphometric alterations that occurred to the remaining testicles in patients who had undergone chemotherapy or radiotherapy for malignant testicular tumours, with findings, on average, being recorded 4.5 years after treatment. Qualitative histological investigations of testicular tissue exhibited differentiated characteristics, with radiotherapy resulting in significantly stronger phenomena. Epithelial height was clearly reduced in conjunction with increase in wall thickness, especially after radiotherapy. Tubular lumens, in the wake of radiotherapy, were more often filled with hyalin than after chemotherapy. Unambiguous evidence was produced to impairment of fertility in response to both chemotherapy and radiotherapy.
Klinik für Nephrologie und Urologie, Bezirkskrankenhauses Aue, DDR.
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Barth
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Büttner
D000328:Adult; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008297:Male; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D013737:Testis / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects
Vergleichende histologische Untersuchungen am germinativen Gewebe nach der Chemo- bzw. Strahlentherapie bei Patienten mit malignen Hodentumoren.