[Immunologic thrombopenic purpura in children: therapeutic trial with high dose of intravenous gamma globulins].
Fifteen children with immunological thrombocytopenic purpura were treated by first intention with high dose intravenous gammaglobulins (Venoglobulins and Sandoglobulins). Nine children recovered after the first injection with platelet counts greater than 50,000/mm3 after 2 days' treatment, so countering the risk of haemorrhage. One child required a second course of treatment and was then cured. Three children had temporary rises in their platelet counts and then relapsed; two children did not react at all to the treatment. The most interesting feature of this new therapeutic approach is the possibility of preventing serious haemorrhagic complications in cases of severe thrombocytopaenia (less than 10,000/mm3) by inducing a rapid rise in the platelet count.
M
M
Portas
D
D
Armengaud
J P
JP
Auffeuvre
A
A
Barois
J P
JP
Gallet
B
B
Leroy
C
C
Magloire
G
G
Blancher
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy*; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy*; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D005719:gamma-Globulins
Purpura thrombopénique immunologique de l'enfant: essai thérapeutique par haute dose de gamma-globulines intra-veineuses. A propos de 15 cas.