The neuropeptide FMRF-amide decreases both the Ca2+ conductance and a cyclic 3',5'-adenosine monophosphate-dependent K+ conductance in identified molluscan neurons.
The molluscan neuropeptide FMRF-amide (10 to 50 microM) decreases the duration of the Ca2+-dependent action potential recorded in the cell body of identified neurons of the snail Helix aspersa (cells D3 and E2). In these neurons, FMRF-amide evokes a decrease of the Ca2+ current resulting from a decrease in Ca2+ conductance. In another single neuron, cell E11, FMRF-amide, besides evoking a decrease of the Ca2+ conductance, induces a decrease of the S-current (Klein, M., J. S. Camardo, and E. R. Kandel (1982) Proc. Natl. Acad Sci. U. S. A. 79: 5713-5717), a K+ current controlled by cyclic AMP. However, in this E11 cell, FMRF-amide also evokes a decrease of the amplitude of the Ca2+ spike plateau. As discussed in the preceding paper (Paupardin-Tritsch, D., L. Colombaioni, P. Deterre, and H. M. Gerschenfeld (1985) J. Neurosci. 5: 2522-2532), it is suggested that these FRMF-amide-induced modulations of ionic conductances involved in the Ca2+-dependent spike recorded in these neuronal somata may intervene in processes of presynaptic inhibition and facilitation.
Colombaioni
L
L
Paupardin-Tritsch
D
D
Vidal
P P
PP
Gerschenfeld
H M
HM
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D019835:FMRFamide; D006372:Helix, Snails / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D009474:Neurons / Q000502:physiology*; D009842:Oligopeptides / Q000494:pharmacology*; D011188:Potassium / Q000502:physiology*
D007473:Ion Channels; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D019835:FMRFamide; D000242:Cyclic AMP; D011188:Potassium; D002118:Calcium; D004298:Dopamine