The effect of ETH 1001 on ion fluxes across red blood cell membranes.
The calcium selective ionophore, ETH 1001, and the divalent cation ionophore, A23187, promoted Ca2+ flux across RBC membranes under various experimental conditions. ETH 1001 did not promote the passive movement of Mg2+ whereas A23187 did. The results confirm the potential application of ETH 1001 as a Ca2+ selective ionophore for biological membranes.
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D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D003959:Diamines / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008274:Magnesium / Q000097:blood; D013997:Time Factors
D003959:Diamines; D007473:Ion Channels; D000001:Calcimycin; C045768:ETH 1001; D008274:Magnesium; D002118:Calcium