Cyclosporine-A as prevention for graft-versus-host disease in pediatric patients undergoing bone marrow transplants.
Cyclosporine-A is a drug commonly used in bone marrow transplantation (BMT) for the prevention of graft-versus-host disease. In the pediatric allogeneic BMT population at The Children's Hospital in Boston, a combination of Cyclosporine-A and Methotrexate is used for graft-versus-host prophylaxis. Graft-versus-host disease, whether acute or chronic, may be fatal. The increasing use of Cyclosporine-A in the pediatric BMT setting demands careful nursing assessment and intervention for Cyclosporine-A toxicity and related side effects.
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Truog
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Wozniak
D016026:Bone Marrow Transplantation; D002648:Child; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use
D003524:Cyclosporins; D008727:Methotrexate