Discovery of a natural spirolactone derivative in man and animal.
The presence of 6,7-dihydroxy-6,7-dihydrocanrenone (DHC) in man and in animal has been shown. Sodium loading results in a decrease of urinary DHC. On the contrary, sodium depletion increases its concentration.
Genard
P
P
Palem-Vliers
M
M
Lomba-Pignon
M R
MR
Christiaens
L
L
De Graeve
J
J
D000818:Animals; D002192:Canrenone / Q000652:urine*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D011245:Pregnadienes / Q000652:urine*; D013148:Spironolactone / Q000378:metabolism* / Q000652:urine
D011245:Pregnadienes; D013148:Spironolactone; D002192:Canrenone