Effect of 6-OHDA injected into the locus coeruleus on apomorphine-induced aggression.
Bilateral microinjections of 6-hydroxydopamine (6-OHDA) into the nuclei loci coerulei (LC) of male Wistar rats resulted in significant depletion of mesencephalic and striatal norepinephrine, accompanied by a small reduction in dopamine content only in the striatum. Apomorphine (2.5 mg/kg IP) induced marked aggression consisting of prolonged posturing, vocalization and attacks only in 6-OHDA lesioned animals. Biochemical analysis revealed that 6-OHDA antagonized the ability of apomorphine to raise the serotonin concentration in the striatum. It is concluded that the LC neurons play an inhibitory role in apomorphine-induced aggressiveness and the involvement of serotonergic neurons is suggested.
Puciłowski
O
O
Kozak
W
W
Valzelli
L
L
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007267:Injections; D008125:Locus Coeruleus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D006892:Hydroxydopamines; D006897:Hydroxyindoleacetic Acid; D016627:Oxidopamine; D001058:Apomorphine