The adjuvant effects of mycoviral dsRNA and polyinosinic:polycytidylic acid on the murine immune response.
By comparing, under the same experimental conditions, the effects of naturally occurring mycoviral dsRNA with those of the synthetic dsRNA, polyinosinic:polycytidylic acid, we were able to determine if the source of the dsRNA would modify its immunomodulating properties. Mycoviral dsRNA, but not the synthetic dsRNA, significantly enhanced the hemagglutinating antibody response to sRBC in C57B1/6 mice. Although both dsRNA preparations significantly increased the rate of rejection of heterologous skin grafts by recipient mice when compared to controls, mycoviral dsRNA induced higher interferon titers than the synthetic dsRNA. This study showed that mycoviral dsRNA was a more potent adjuvant than polyinosinic:polycytidylic acid for both humoral and cellular immune responses.
C L
CL
Wright
J P
JP
Alder-Moore
D000276:Adjuvants, Immunologic; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006084:Graft Rejection; D006386:Hemagglutination Tests; D007111:Immunity, Cellular; D007372:Interferons / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D011070:Poly I-C / Q000276:immunology*; D012330:RNA, Double-Stranded / Q000276:immunology*; D012367:RNA, Viral / Q000276:immunology*; D012441:Saccharomyces cerevisiae / Q000032:analysis; D016038:Skin Transplantation; D014181:Transplantation Immunology
D000276:Adjuvants, Immunologic; D000906:Antibodies; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D007372:Interferons; D011070:Poly I-C