[Effect of benzylpenicillin and tetracycline on phagocytic and humoral activity and biochemical indices in experimental animals with staphylococcal infection].
The effect of benzylpenicillin and tetracycline on phagocytosis by leukocytes of abdominal cavity exudate, activity of lysozyme and beta-lysines in the blood serum, content of nucleic acids and activity of succinate dehydrogenase and phosphatase (total and acid) in the liver cells was studied on albino mice infected by staphylococci. It was shown that the treatment of the animals with benzylpenicillin and tetracycline for 5 days affected the cellular and nonspecific humoral defence and activity of succinate dehydrogenase and phosphatase. A decrease in the indices of the phagocytosis, activity of lysozyme, beta-lysines, succinate dehydrogenase and phosphatase was observed. Tetracycline had a more pronounced inhibitory effect. Neither benzylpenicillin, nor tetracycline had an effect on the content of nucleic acids in liver cells.
N I
NI
Balakliets
A Ia
AIa
Tsyganenko
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D004247:DNA / Q000378:metabolism; D007109:Immunity / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009113:Muramidase / Q000097:blood; D010400:Penicillin G / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011506:Proteins; D012313:RNA / Q000378:metabolism; D013203:Staphylococcal Infections / Q000276:immunology*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013752:Tetracycline / Q000494:pharmacology*
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D011506:Proteins; C011679:beta lysin, human; C475592:beta lysin, mouse; D012313:RNA; D004247:DNA; D013385:Succinate Dehydrogenase; D010744:Phosphoric Monoester Hydrolases; D009113:Muramidase; D013752:Tetracycline; D010400:Penicillin G
Vliianie benzilpenitsillina i tetratsiklina na fagotsitarnuiu i gumoral'nuiu aktivnost' i biokhimicheskie pokazateli u éksperimental'nykh zhivotnykh pri stafilokokkovoĭ infektsii.