Prognostic factors in patients with bladder carcinoma treated with definitive irradiation.
An analysis was performed of 116 patients with bladder carcinoma who completed definitive radiotherapy at a single institution. Patients were analyzed for survival and local control. The overall 5-year survival rate was 34%. A multivariate analysis of survival showed disease stage, hemoglobin level, histologic grade, and total dose to be significant factors in outcome. The local control rates for Stage A, B, C, and D patients were 26%, 36%, 18%, and 0%, respectively. The multivariate analysis revealed disease stage and pretreatment hemoglobin level to be significant predictors of local control. In patients unsuitable for surgery or current combined technique protocols, high-dose irradiation may offer some patients survival and local control. Furthermore, prognostic factors in this study may aid in the stratification necessary for current protocol designs.
Greven
K M
KM
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia.
Solin
L J
LJ
Hanks
G E
GE
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery
D006441:Hemoglobin A