[Effect of substance P on catecholamine levels in the hypothalamus and midbrain in the rat during immobilization stress].
Single intraperitoneal injection of substance P in a dose of 125 mcg/kg induced a significant increase of noradrenaline and dopamine level in the hypothalamus and the midbrain of intact rats. Under conditions of immobilization emotional stress, the substance P eliminated the stress induced decrease of hypothalamic noradrenaline and increase of its level in the midbrain; in other words the substance P normalized the noradrenaline level. Modulatory effect of a single injection of the substance P had a long-term character and was synchronized with an earlier found increase of resistability of rats to chronic emotional stress.
E A
EA
Iumatov
I P
IP
Anokhina
L N
LN
Mezentseva
Iu G
IuG
Skotselias
D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D006801:Humans; D007031:Hypothalamus / Q000032:analysis*; D008297:Male; D008636:Mesencephalon / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*; D013373:Substance P
D002395:Catecholamines; D013373:Substance P; D004298:Dopamine; D009638:Norepinephrine
Vliianie substantsii P na uroven' katekholaminov v gipotalamuse i srednem mozge u krys pri immobilizatsionnom stresse.