Magnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats.
In a qualitative electron microscopy study we initially reported that exposure of rats to a standard clinical magnetic resonance imaging (MRI) procedure temporarily increased the blood-brain barrier (BBB) permeability to horseradish peroxidase. In this study, we quantitatively support our initial finding. Rats were injected intracardially with radio-labelled diethylenetriaminepentaacetic acid [( 153Gd]DTPA) in the middle of two sequential 23.2 min MRI exposures. Exposed rats (n = 21) showed significantly greater (29%, P = 0.006) retention of [153 Gd]DTPA than sham-exposed rats (n = 22) 1 h after the end of the last 23.2 min exposure. These findings suggest that magnetic fields may alter BBB permeability.
Department of Nuclear Medicine, St. Joseph's Health Centre, London, Ont., Canada.
F S
FS
Prato
J R
JR
Frappier
R R
RR
Shivers
M
M
Kavaliers
P
P
Zabel
D
D
Drost
T Y
TY
Lee
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005682:Gadolinium / Q000378:metabolism*; D019786:Gadolinium DTPA; D006735:Horseradish Peroxidase / Q000097:blood / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000378:metabolism*; D004369:Pentetic Acid / Q000378:metabolism*; D010539:Permeability; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
D009942:Organometallic Compounds; D011868:Radioisotopes; D004369:Pentetic Acid; D005682:Gadolinium; D006735:Horseradish Peroxidase; D019786:Gadolinium DTPA