Biochemical markers as prognostic indices in breast cancer.
Traditional prognostic markers in breast cancer include histological variables such as tumor size, grade, and axillary node status. In recent years some new potential prognostic markers of a biochemical nature have been described: estradiol receptors, progesterone receptors, epidermal growth factor receptors, erbB-2 proto-oncogene, and certain proteolytic enzymes. None of these new markers excels axillary node status as a prognostic marker. Biochemical markers can, however, be evaluated with use of minimal surgery and may help distinguish the minority of aggressive axillary-node-negative breast cancers.
Nuclear Medicine Dept., St. Vincent's Hospital, Dublin 4, Ireland.
M J
MJ
Duffy
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D011379:Prognosis; D000090063:Proto-Oncogene Mas
D014408:Biomarkers, Tumor; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas