Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia.
We have examined the level of c-myc transcripts in prostate tissue obtained from patients with both benign prostatic hyperplasia and adenocarcinoma of the prostate. A significantly higher level of c-myc transcripts is observed in patients with adenocarcinoma (P less than 0.05). In addition, a subset of patients with adenocarcinoma had levels of c-myc transcripts 2-fold higher than the mean level for this group. These preliminary results indicate that the investigation of c-myc levels as a prognostic indicator in prostatic carcinoma is warranted.
Fleming
W H
WH
Hamel
A
A
MacDonald
R
R
Ramsey
E
E
Pettigrew
N M
NM
Johnston
B
B
Dodd
J G
JG
Matusik
R J
RJ
D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D000135:Acid Phosphatase