Efficacy of combined antidepressant therapy in resistant neurotic disorder.
A 35-year-old woman with persistent affective and phobic symptoms responded dramatically to a combination of isocarboxazid and amitriptyline, and this improvement was maintained over the next three-and-a-half years. Isocarboxazid was replaced by placebo, using double-blind procedure. The change to placebo was accompanied by a marked increase in anxiety and depressive symptoms, which resolved when active isocarboxazid was reintroduced. It is suggested that combined antidepressant therapy still has a place in the treatment of resistant neurotic disorder.
St Charles' Hospital, London.
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P
Tyrer
S
S
Murphy
D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage*; D001008:Anxiety Disorders / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D003975:Diazepam / Q000008:administration & dosage; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000008:administration & dosage*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D010624:Phenelzine / Q000008:administration & dosage; D010698:Phobic Disorders / Q000188:drug therapy*
D000639:Amitriptyline; D007520:Isocarboxazid; D010624:Phenelzine; D003975:Diazepam