Different antigen-presenting cells differ in their capacity to induce lymphokine production and proliferation of an apo-cytochrome c-specific T cell clone.
The activation of an apo-cytochrome c-specific T cell clone was found to differ, depending on the antigen-presenting cell population. Whereas total syngeneic spleen cells and bone marrow macrophages could be shown to trigger proliferation, IL 2, and MAF production by the T cell clone, a B cell lymphoma only induced MAF secretion. Further studies demonstrated that this effect was not due to a different antigen processing by the B lymphoma or to limiting amounts of Ia and antigen molecules on the B lymphoma cell surface. The dissociation of induction of MAF production from IL-2 production/proliferation found with the different antigen-presenting cells indicates strongly that molecules other than Ia and antigen may be required for the complete functional activation of antigen-specific T cell clones.
Baumhüter
S
S
Bron
C
C
Corradin
G
G
D000818:Animals; D000938:Antigen-Presenting Cells / Q000145:classification* / Q000276:immunology; D001059:Apoproteins / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001854:Bone Marrow Cells; D002460:Cell Line; D002999:Clone Cells / Q000145:classification / Q000276:immunology; D003574:Cytochrome c Group / Q000276:immunology*; D045304:Cytochromes c; D000939:Epitopes; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis*; D008223:Lymphoma / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000378:metabolism*
D001059:Apoproteins; D003574:Cytochrome c Group; D000939:Epitopes; D008222:Lymphokines; D045304:Cytochromes c