Bradykinin accelerates mucociliary activity in rabbit maxillary sinus.
The in vivo effect of bradykinin on mucociliary (m.c.) activity in the rabbit maxillary sinus was investigated by administering the substance (0.01-10.0 micrograms/kg) via arteria maxillaris and recording the responses with a non-invasive photoelectric technique. Bradykinin accelerated the m.c. activity in a dose-dependent manner in the dose range 0.05-10.0 micrograms/kg. While the action of bradykinin was resistant to pretreatment with indomethacin 10.0 mg/kg, it was considerably weakened by the substance P antagonist [D-Pro2, D-Trp7,9]SP 1 mg/kg. The initial effect of bradykinin was also suppressed by atropine, suggesting that bradykinin accelerates m.c. activity by a dual mechanism comprising both SP and acetylcholine. Bradykinin probably stimulates a reflex arc in the airways involving afferent SP neurons and efferent post-ganglionic parasympathetic neurons.
Lindberg
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Mercke
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D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001920:Bradykinin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008443:Maxillary Sinus / Q000187:drug effects*; D009093:Mucus / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology
D011448:Prostaglandin Antagonists; D011976:Receptors, Muscarinic; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P; D001285:Atropine; C032132:substance P, prolyl(2)-tryptophan(7,9)-; D001920:Bradykinin; D007213:Indomethacin