Computer simulation (based on a linear-elution-strength approximation) as an aid for optimizing separations by programmed-temperature gas chromatography.
If the dependence of retention on temperature is specified for the various components of a sample in isothermal gas chromatography (GC), it is possible to predict retention, bandwidth, and resolution for programmed-temperature GC separations as a function of experimental conditions. The use of a linear-elution-strength (LES) approximation for isothermal retention allows these predictions to be carried out more easily and conveniently, in turn facilitating rapid simulations with a personal computer. This approach to GC method development appears promising, especially if segmented-temperature programs are used. The LES approximation also provides added insight into how different factors affect separation in programmed-temperature GC.
LC Resources, Inc., Lafayette, California 94549.
D E
DE
Bautz
J W
JW
Dolan
W D
WD
Raddatz
L R
LR
Snyder
D002849:Chromatography, Gas / Q000295:instrumentation*; D003198:Computer Simulation; D013696:Temperature