The relationship of the antigenic determinants expressed by rat lymphoid cells to their participation in graft-versus-host reactions.
The relationship between the graft-versus-host reactivity of lymphocytes from F2 hybrid and backcross rats and their susceptibility to inter-parental strain alloantisera has been investigated. Apart from associations between the immunological responsiveness of individual rats and the extent of alloantiserum susceptibility of their lymphocytes, selective reactivity of groups of lymphocytes that were separable from the general population by means of their alloantiserum susceptibility was observed. Those host lymphocytes which expressed a preponderance of DA-derived determinants were preferentially implicated in graft-versus-host reactions elicited by PVG lymphocytes in (PVG X DA)F2 hybrid rats. The anti-(PVG X DA)F1 hybrid reactivity of some (PVG X F1) backcross rats was selectively concentrated in that fraction of the lymphocyte population which expressed the highest levels of PVG-derived determinants. It is proposed that heterogeneously expressed MHS determinants may have a role in regulating selective participation by subpopulations of lymphocytes in allogeneic reactions.
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McCullagh
D000818:Animals; D003433:Crosses, Genetic; D000939:Epitopes / Q000276:immunology*; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051381:Rats; D014184:Transplantation, Homologous
D000939:Epitopes; D006649:Histocompatibility Antigens; D007518:Isoantibodies; C038353:histocompatibility antigens RT, rat