[Antiproliferative effect of interferon inducers].
The antiproliferative effect of clinically promising interferon inducers, phage f2 ambermutant dsRNA, polyguacyl, tiloron, Tash-4, was demonstrated in Raji lymphoblastoid cells. Concentrations of the inducers producing death of 48-66% of Raji cells were determined to be: for dsRNA, 200 micrograms/ml; polyguacyl, 400 micrograms/ml; tiloron, 100 micrograms/ml; Tash-4, 200 micrograms/ml, which corresponded to the antiproliferative effect of 200 units/ml of alpha-interferon and 40 units/ml of gamma-interferon. No antiproliferative effect was observed at dsRNA, polyguacyl, and Tash-4 concentrations below 100 micrograms/ml. None of the inducers exerted the antiproliferative effect on the selected concentrations on normal human diploid cells. The results obtained explain the antitumorigenic effect of these inducers, demonstrated previously.
L A
LA
Lavrukhina
F I
FI
Ershov
D002051:Burkitt Lymphoma / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology
D007369:Interferon Inducers; D007372:Interferons
Antiproliferativnyĭ éffekt induktorov interferona.