Prediction of deep vein thrombosis after extensive abdominal operations by the quotient between plasmin-alpha 2-antiplasmin complex and fibrinogen concentration in plasma.
In 97 patients over 49 years of age who underwent extensive abdominal operations, post-operative deep vein thrombosis was prospectively diagnosed by the 125I-fibrinogen test. Blood was sampled preoperatively for analysis of the plasma levels of PAP (by a radioimmunoassay) and fibrinogen. The development of postoperative deep vein thrombosis was correlated to the quotient between the preoperative plasma concentration of PAP and fibrinogen. The quotient was significantly lower in the 30 patients who had thrombosis develop postoperatively as compared with the patients who did not. A simple linear discrimination analysis showed that, in the 31 patients with a quotient of more than 0.48, only two patients (6 per cent) had deep vein thrombosis. The results emphasize the importance of the preoperative fibrinolytic status in the development of postoperative deep vein thrombosis. The results of the study indicate that the quotient between PAP and fibrinogen concentration in plasma might be used for the prediction of patients with a high risk for having deep vein thrombosis develop after undergoing extensive abdominal operations.
G
G
Mellbring
S
S
Dahlgren
B
B
Wiman
D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents; D004066:Digestive System Diseases / Q000097:blood / Q000601:surgery*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012306:Risk; D013924:Thrombophlebitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D000933:Antifibrinolytic Agents; D000979:alpha-2-Antiplasmin; C037742:plasmin-plasmin inhibitor complex; D005340:Fibrinogen; D005341:Fibrinolysin