The clinical and immunologic efficacy of immunotherapy with modified ragweed extract (allergoid) for ragweed hay fever.
A double-blind study comparing formaldahyde modified ragweed allergen (allergoid) and placebo in the treatment of allergic rhinitis was carried out. Twenty ragweed-sensitive patients were studied, ten receiving 10,710 PNU of allergoid pre-seasonally and ten receiving placebo injections. Daily symptom score sheets were kept by each patient during August and September of 1983. A significant difference in average daily symptom scores (P = 0.01) between the two groups was noted. Significant differences were also observed in symptom scores for individual weeks during the ragweed season. Post-treatment allergen-specific IgG blocking antibody was significantly higher (P = 0.001) in the treatment group compared to pre-treatment levels and when compared to the control group (P = 0.01). No significant local or systemic reactions occurred. The results suggest that the dosage protocol used in this study is appropriate as an initial treatment schedule in clinical practice.
Meriney
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DK
Kothari
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H
Chinoy
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P
Grieco
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MH
D000328:Adult; D000080384:Allergoids; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001667:Binding, Competitive; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D000939:Epitopes; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D010919:Placebos; D010936:Plant Extracts / Q000627:therapeutic use*; D011058:Pollen / Q000276:immunology; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*; D012882:Skin Tests
D000080384:Allergoids; D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D010919:Placebos; D010936:Plant Extracts; D007073:Immunoglobulin E