Efficacy of different hexacyanoferrates(II) in inhibiting the intestinal absorption of radiocaesium in rats.
The inhibitory effect of various oral doses of different hexacyanoferrate(II) compounds (HCF) and the influence of the time interval of HCF-administration on intestinal 134Cs-absorption was studied in rats. Optimum inhibition was obtained by administration of HCF together with or 2 min before oral 134Cs loading. Using appropriate low amounts (0.1-0.5 mg) of the different HCF compounds, the inhibitory effect increased in the sequence KZnHCF less than KCuHCF less than FeHCF less than KCoHCF = KNiHCF less than NH4FeHCF = KFeHCF. Oral administration of 5 mg (0.5 mg) of KFeHCF, together with 134CsCl loading, reduces 134Cs-absorption from 41% (control) to 0.8% (2.8%). Zinc-, copper-, cobalt, and nickel hexacyanoferrates(II), despite showing a high caesium sorption capacity in vitro, were less effective in rats and are not suited for in vivo application, also because they may produce toxic side effects. As a consequence, the orally administered colloidal-soluble iron(III) hexacyanoferrates(II) (NH4Fe[Fe(CN)6] and KFe[Fe(CN)6]) have to be considered as the most valuable countermeasure against radiocaesium absorption for humans and domestic animals in the case of a severe nuclear accident in the future. Manganese oxide, a non-hexacyanoferrate(II) compound with known in vitro caesium binding capacity, showed no inhibitory effect on radiocaesium absorption in rats.
Abteilung Medizinische Biochemie, Universitätskrankenhaus Eppendorf, Hamburg, Bundesrepublik Deutschland.
B
B
Dresow
P
P
Nielsen
H C
HC
Heinrich
D000818:Animals; D002586:Cesium / Q000378:metabolism*; D002588:Cesium Radioisotopes; D002712:Chlorides; D005260:Female; D005295:Ferrocyanides / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D002588:Cesium Radioisotopes; D002712:Chlorides; D005295:Ferrocyanides; D002586:Cesium; C028019:cesium chloride