[Nonspecific immunotherapy with BCG vaccine in bladder tumors].
Clinical experience is recorded and summarized with the application of BCG vaccine for prophylaxis, treatment and immunochemotherapy of bladder tumors for the period June 1985-January 1988. Included in the study were 85 patients distributed in five groups: 23 patients treated for prevention of relapses; 26 treated for existing and residual surface tumors; 13 in whom BCG vaccine F-70 was applied for prophylaxis purpose; 17 with surface tumors treated only surgically--control group; 10 patients with advanced bladder tumor treated with immunochemotherapeutic agents. Once the results have been reported and discussed, the following inferences were made: 1. Intravesical BCG vaccine is a new effective and practicable method for prophylaxis and treatment of surface bladder tumors; 2. A 12-month course of treatment with the new Bulgarian Kalgevax showed high therapeutic activity; 3. Indications and possibilities for treatment of existing and residual surface tumors with intravesical BCG vaccine are given; complete effect of treatment was obtained in 21 patients (81 per cent); 4. The side reactions of the application of BCG vaccine and the possibilities for their reduction are presented; 5. The first results of application of immunotherapy in advanced bladder tumors are encouraging.
Damianov
Kh
Kh
Patrashkov
T
T
Petkov
Ts
Ts
Tonchev
T
T
Petrov
P
P
D000283:Administration, Intravesical; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001500:BCG Vaccine / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*; D007271:Injections, Intradermal; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011182:Postoperative Care; D001749:Urinary Bladder Neoplasms / Q000517:prevention & control / Q000628:therapy*
D001500:BCG Vaccine; D015251:Epirubicin; D003520:Cyclophosphamide; D002945:Cisplatin
Nespetsifichna imunoterapiia s BTsZh vaksina pri tumori na pikochniia mekhur.