[Interleukin 1].
Interleukin-1 (IL-1) is secreted by macrophages, macrophage-like cells (e.g. Langerhans cells) and by astrocytes, keratinocytes, fibroblasts or natural killer cells. IL-1 is directly involved in the activation of helper T lymphocytes. However, it has been shown that IL-1 also induces release of collagenase and prostaglandins by fibroblasts. Furthermore, injections of IL-1 into animals are followed by fever, leukocytosis, increased serum concentrations of fibrinogen, serum amyloid A and haptoglobin, and decreased levels of iron and zinc. IL-1 has been extracted from experimental granuloma and from tissues of animals with endotoxinemia. Synovial fluids from patients with osteoarthritis contain significant amounts of IL-1. All in all, IL-1 may be ultimately involved in the development of fever and fibrosis, in the destruction of joints and the activation of T lymphocytes during inflammatory processes.
Fontana
A
A
Bodmer
S
S
Frei
K
K
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D000939:Epitopes; D005334:Fever / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D010003:Osteoarthritis / Q000276:immunology; D011458:Prostaglandins E / Q000096:biosynthesis; D014176:Protein Biosynthesis; D011658:Pulmonary Fibrosis / Q000276:immunology; D011749:Pyrogens / Q000096:biosynthesis; D051381:Rats; D012890:Sleep / Q000502:physiology; D013582:Synovial Fluid / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000939:Epitopes; D007375:Interleukin-1; D011458:Prostaglandins E; D011749:Pyrogens; C008270:leukocyte endogenous mediator
Interleukin-1.