Chronic induction of interferon by continuous infusion of polyriboinosinic:polyribocytidilic acid.
In an attempt to induce circulating interferon (IFN) chronically, C57BL/6 or Balb/cBy mice received daily injections or continuous infusion of polyriboinosinic:polyribocytidilic acid [poly(I:C)] i.p. for 7 days. Significantly higher plasma IFN was present in C57BL/6 mice receiving poly(I:C) via continuous infusion compared with daily injections. Spleen and bone marrow natural killer (NK) cells were elevated only in the group receiving poly(I:C) continuously. Little IFN was induced acutely in Balb/cBy mice and none was present after chronic infusion of poly(I:C). NK cells were not elevated. Continuous infusion of poly(I:C) appears to overcome the hyporesponsiveness to repeated IFN induction in a susceptible mouse strain.
Rothmann
S A
SA
Paul
P
P
Oluic'
T J
TJ
Sturkie
K A
KA
Proffitt
M R
MR
D000818:Animals; D005260:Female; D007372:Interferons / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011070:Poly I-C / Q000494:pharmacology*
D007372:Interferons; D011070:Poly I-C