Effect of proglumide on rat pancreatic growth.
Proglumide, a glutaramic acid derivative, is a specific competitive inhibitor of gastrin and cholecystokinin (CCK) receptors. As such, it blocks gastrin-stimulated acid secretion, the trophic effect of gastrin, and CCK-stimulated smooth muscle contraction and acinar cell secretion. In the current study we have demonstrated that proglumide (100 mg/kg three times per day) blocks the trophic effect of a low dose of CCK octapeptide (300 ng/kg) given three times a day for 2 days. The same dose of proglumide when given alone for 6 days, however, resulted in a significant stimulation of pancreatic growth. Proglumide had no effect on the trophic response to a high dose of CCK-OP (5 micrograms/kg) administered for either 2 or 6 days. These results indicate that given over a period of several days proglumide behaves like a partial agonist of pancreatic growth.
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D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D004247:DNA / Q000096:biosynthesis; D005755:Gastrins / Q000097:blood; D005973:Glutamine / Q000031:analogs & derivatives*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D011377:Proglumide / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000037:antagonists & inhibitors
D005755:Gastrins; D011506:Proteins; D005973:Glutamine; D012313:RNA; D004247:DNA; D002766:Cholecystokinin; D011377:Proglumide; D012844:Sincalide