No effect of systemic administration of somatomedin C on bone repair in rats.
The effect of somatomedin C on the bone repair process was studied in a rat femoral osteotomy. We used continuous systemic administration of human recombinant somatomedin C (110 micrograms/100 g per day). Radiographic evaluation after 4 weeks showed no effect of somatomedin C on the healing. There was no effect on mechanical strength, and no effect was found on callus vascularization or mineralization. The weight of the callus was slightly reduced in the somatomedin C treated rats. The results were not suggestive of any acceleration with systemic somatomedin C treatment in the early phase of cortical bone repair.
Institute for Surgical Research and Sophies Minde Orthopedic Hospital, University of Oslo, Norway.
O J
OJ
Kirkeby
A
A
Ekeland
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology / Q000601:surgery; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D010027:Osteotomy; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins; D013002:Somatomedins / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
D011994:Recombinant Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I