Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study.
Ten Alzheimer's disease patients underwent a trial of oral tetrahydroaminoacridine (THA) and lecithin. After 3 inpatient weeks there was no clear therapeutic effect. Three of six patients able to continue in long-term treatment showed measurable cognitive improvement, but only one displayed clinically obvious improvement.
Fitten
L J
LJ
VA Medical Center, Sepulveda, Calif 91343.
Perryman
K M
KM
Gross
P L
PL
Fine
H
H
Cummins
J
J
Marshall
C
C
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D000609:Aminoacridines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D013619:Tacrine / Q000627:therapeutic use*
D000609:Aminoacridines; D010713:Phosphatidylcholines; D013619:Tacrine