Minimal effect of complete H1 receptor blockade on urticaria pigmentosa.
The effect of complete H1 receptor blockade on urticaria pigmentosa was studied in 6 patients. Astemizole 10 mg tds was given for 6 weeks to achieve complete H1 receptor blockade and the response measured by change in force-weal response measurements using two different forces on a dermographic stylus and measuring response as weal diameter. Weal and flare reactions to 8 micrograms histamine were completely abolished by the astemizole but dermographic weal-force responses were reduced only by 12-15% indicating that histamine acting at the H1 receptor plays only a small part in the wealing of urticaria pigmentosa.
L B
LB
Krause
S
S
Shuster
D000328:Adult; D016589:Astemizole; D001562:Benzimidazoles / Q000627:therapeutic use*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D014582:Urticaria Pigmentosa / Q000188:drug therapy* / Q000276:immunology
D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016589:Astemizole