Extramammary Paget's disease of the perianal and perineal regions. Evidence of apocrine derivation.
A case of perianal and perineal extramammary Paget's disease in a male is reported. The presence of gross cystic disease fluid protein--a new marker of apocrine epithelia--in Paget's cells provides additional insight into the histopathogenesis of this condition. This marker may be a valuable diagnostic adjunct in evaluating intra-epithelial malignancies at a variety of anatomic sites.
Merot
Y
Y
Mazoujian
G
G
Pinkus
G
G
Momtaz-T
K
K
Murphy
G F
GF
D000368:Aged; D001003:Anal Canal / Q000473:pathology*; D001050:Apocrine Glands / Q000473:pathology*; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002352:Carrier Proteins; D006023:Glycoproteins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins / Q000032:analysis; D010145:Paget Disease, Extramammary / Q000032:analysis / Q000473:pathology*; D010502:Perineum / Q000473:pathology*; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*; D013545:Sweat Glands / Q000473:pathology*
C024328:APOD protein, human; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002272:Carcinoembryonic Antigen; D002352:Carrier Proteins; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins; D007633:Keratins