[Immunohistochemical characterization of lymphocytes and histiocytes in bladder cancers in terms of local immune responses].
Ten resected bladder cancers were studied immunohistochemically using monoclonal antibodies to clarify the subsets of infiltrating lymphocytes and histiocytes. Leu 4+ T-lymphocytes infiltrated diffusely both in the stroma and the submucosal tissue, but Bl+ B-lymphocytes usually formed follicle-like clusters in the submucosal tissue. The number of Leu 4+, Leu 3 a+ helper/inducer T-lymphocytes was considerably more than that of Leu 4+, Leu 2 a+ suppressor/cytotoxic T-lymphocytes. Leu 7+ natural killer cells were sparsely present in the submucosal tissue, and there was no suggestion of any significant contact with cancer cells. OKT9+ OKM1+ macrophages were prominent in the inflammatory lesions, but OKT6+ T-zone histiocytes were characteristically present among the cancer cells. Patients with dense infiltration of OKT6+ T-zone histiocytes were expected to have a good prognosis.
S
S
Hanai
Y
Y
Shimosato
S
S
Watanabe
Y
Y
Sato
K
K
Kishi
T
T
Kakizoe
K
K
Matsumoto
D000368:Aged; D000911:Antibodies, Monoclonal; D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000276:immunology*; D006651:Histocytochemistry; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal