Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat.
This paper describes the induction of uterine eosinophilia as well as of deep endometrial edema and increase of uterine wet weight in the immature rat by the catecholestrogens 2-OH-estradiol and 4-OH-estradiol. These effects are thought to be mediated by eosinophils via a specific eosinophil receptor system. 4-OH-estradiol was equipotent with estradiol, whereas the effect of 2-OH-estradiol was significantly weaker.
Baumann
P
P
Tchernitchin
A N
AN
Grunert
G
G
Ball
P
P
D000818:Animals; D004247:DNA / Q000378:metabolism; D004487:Edema / Q000209:etiology; D004802:Eosinophilia / Q000139:chemically induced* / Q000150:complications; D004804:Eosinophils / Q000473:pathology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002393:Estrogens, Catechol; D005260:Female; D009929:Organ Size; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014591:Uterine Diseases / Q000139:chemically induced* / Q000473:pathology; D014599:Uterus / Q000473:pathology
D002393:Estrogens, Catechol; D004958:Estradiol; D012313:RNA; D004247:DNA; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol