The effect of concomitantly administered antacids on the bioavailability of lornoxicam, a novel highly potent NSAID.
Antacids are used in the treatment of upper gastrointestinal side-effects during therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Since pharmacokinetic interactions between antacids and NSAIDs have been reported, it was investigated whether aluminium and magnesium hydroxide (Maalox as oral suspension) or aluminium hydroxide and calcium carbonate (Solugastril as oral gel) influenced the bioavailability of Lornoxicam (rINN), a new potent NSAID from the chemical group of the oxicams. Eighteen male volunteers were given 4 mg of Lornoxicam as a film-coated tablet either alone or together with 10 ml of Maalox or 10 g of Solugastril in an open, randomized, three-way cross-over study. The levels of Lornoxicam in plasma were determined by HPLC following solid-phase extraction. It was found that none of the antacids changed significantly any of the following pharmacokinetic parameters: elimination half-life (t1/2 beta), concentration at peak time (Cmax), time to reach the peak (tmax) and area under the curve to infinity (AUCo-infinity). The results indicate that the concomitant administration of antacids did not influence the pharmacokinetic profile of Lornoxicam. Furthermore they confirm the short elimination half-life of Lornoxicam in man, which is markedly shorter than that of other oxicam-type compounds.
Institute of Pharmacodynamics and Toxicology, University of Graz, Austria.
P
P
Dittrich
S
S
Radhofer-Welte
D
D
Magometschnigg
W R
WR
Kukovetz
S
S
Mayerhofer
H P
HP
Ferber
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D002119:Calcium Carbonate / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006801:Humans; D008276:Magnesium Hydroxide / Q000494:pharmacology; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D000863:Antacids; D010894:Piroxicam; D000536:Aluminum Hydroxide; C059451:lornoxicam; D002119:Calcium Carbonate; D008276:Magnesium Hydroxide