[A brief review of outflow facility from the viewpoint of metabolic inhibitors].
Aqueous humor is generally considered to flow through the trabecular meshwork without requiring pumping energy from this tissue. Previous studies of the influence of metabolic inhibitors were done mostly at room temperature and usually showed no effect. However, we found that, when tested at 35-36 degrees C, F- reduced the facility of outflow of enucleated bovine eyes. Furthermore, F- did not significantly change the tone of the isolated bovine ciliary muscle, thus the mechanical opening of the trabecular meshwork "pore" could be eliminated. The author made a brief review in this article that outflow facility might happen to be altered by changes in cellular activity involving metabolic processes in the aqueous drainage system.
Dept. of Ophthalmol, Yamaguchi Univ. School of Med., Ube, Japan.
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Suzuki
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D002417:Cattle; D066298:In Vitro Techniques; D012969:Sodium Fluoride / Q000494:pharmacology*; D013696:Temperature; D014129:Trabecular Meshwork / Q000187:drug effects* / Q000378:metabolism
D012969:Sodium Fluoride