Microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit).
To determine whether GH has an independent action on cerebral development, we examined the central nervous system of the little mouse (lit), a promising model of isolated growth hormone deficiency. Our findings are (A); the weights of two parts of the lit brain were significantly less than those of the normal controls, 81.5% less for the cerebrum, and 81.6% for the cerebellum, (B): the total DNA content was reduced to approximately 80% in the cerebrum and 84% in the cerebellum compared to those of the normal controls, (C); the total RNA content was also reduced in the cerebrum and cerebellum, proportional to the reduction in DNA, (D); CNPase activity was reduced selectively in the cerebrum of the lit mouse (74.4% of the normal control), and (E); the lit mice exhibited a strikingly reduced level of activity with an indistinct diurnal periodicity. These results indicate that GH has independent actions on cerebral development, especially on glial cell proliferation as a precondition of myelin formation.
Noguchi
T
T
Sugiasaki
T
T
Tsukada
Y
Y
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D002940:Circadian Rhythm; D004247:DNA / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008831:Microcephaly / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009043:Motor Activity / Q000502:physiology; D009186:Myelin Sheath / Q000502:physiology*; D010727:Phosphoric Diester Hydrolases; D012313:RNA / Q000378:metabolism
D012313:RNA; D013006:Growth Hormone; D004247:DNA; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571338:Cnp protein, mouse