Variation in foot-and-mouth disease virus isolates in Kenya: an examination of field isolates by T1 oligonucleotide fingerprinting.
Ribonuclease T1 oligonucleotide maps of strains of 4 of the endemic serotypes of foot-and-mouth disease virus isolated in Kenya between 1964 and 1982 have been compared with data obtained in complement-fixation and neutralization tests. There was a continual change in the oligonucleotide maps obtained for all the serotypes examined. This genetic heterogeneity was generally associated with antigenic variation. Viruses isolated during the 12-month course of an epidemic of the SAT 1 serotype showed few changes in their oligonucleotide fingerprints, and were serologically related. These maps form a data base that will be useful in future epidemiological studies on the maintenance and spread of foot-and-mouth disease virus in this region.
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Anderson
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Underwood
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Brown
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Ngichabe
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005537:Aphthovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D002417:Cattle; D000939:Epitopes; D005095:Exoribonucleases; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D014644:Genetic Variation; D007630:Kenya; D009843:Oligoribonucleotides / Q000032:analysis; D012703:Serotyping
D000956:Antigens, Viral; D000939:Epitopes; D009843:Oligoribonucleotides; D005095:Exoribonucleases; C042081:exoribonuclease T