T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo.
B cell-deficient, rabbit anti-mouse IgM-treated mice were compared with normal or normal rabbit immunoglobulin-treated controls in their ability to develop proliferative T cell responses, delayed hypersensitivity, and primary or secondary cytotoxic T cell responses. Immunization with hapten-coupled autologous spleen cells resulted in anti-mu-treated mice generating only marginal T cell responses. This decreased responsiveness was shown to be attributable not to an intrinsic T cell defect or to changes in the ability of macrophages from anti-mu-treated mice to present soluble antigen, but rather to the greatly diminished capacity of B cell-deficient spleen cells to present antigen. The results support the concept that B cells play a significant role in antigen presentation required for T cell activation.
K T
KT
Hayglass
S J
SJ
Naides
C F
CF
Scott
B
B
Benacerraf
M S
MS
Sy
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000502:physiology; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007075:Immunoglobulin M / Q000502:physiology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008231:Lymphopenia / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D007075:Immunoglobulin M; C044203:anti-IgM; D010132:p-Azobenzenearsonate