Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization.
BALB/c mice subjected to a single dose of UV-B radiation showed suppressed contact hypersensitivity to trinitrochlorobenzene. The in vitro antigen reactivity of peritoneal cells from these mice was investigated using the leucocyte-adherence inhibition assay. These cells showed a high degree of reactivity with specific antigen. However, this reactivity, but not the reactivity of cells from non-irradiated sensitized mice, could be suppressed by serum from UV-treated sensitized mice. The suppressive effect of this serum could also be demonstrated on other syngeneic systems with unrelated antigens and was partially effective with allogeneic cells, indicating a lack of antigen specificity and genetic restriction. Suppressive properties were also found in serum taken from mice 3-5 days (but not at other times) after irradiation without subsequent sensitization.
T G
TG
Harriott-Smith
W J
WJ
Halliday
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D000939:Epitopes; D005260:Female; D007111:Immunity, Cellular / Q000528:radiation effects*; D007957:Leukocyte Adherence Inhibition Test; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010853:Picryl Chloride / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays
D000939:Epitopes; D013491:Suppressor Factors, Immunologic; D010853:Picryl Chloride