Current contributions of peptide synthesis to studies on brain-gut-skin triangle peptides.
The usefulness of a strong acid, such as MSA or TFMSA/TFA, as a deprotecting reagent in peptide synthesis was examined. By synthesizing several structurally related brain-gut-skin triangle peptides, a number of advantageous features of the thioanisole-mediated deprotecting procedure were demonstrated. New amino acid derivatives, Arg(Mts), Trp(Mts) and Asp(OChp), were introduced to improve the synthetic methodology of complex peptides and the superior properties of Cys(Ad) were evaluated.
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Yajima
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Funakoshi
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Akaji
D000595:Amino Acid Sequence; D000818:Animals; D001839:Bombesin / Q000138:chemical synthesis; D001921:Brain / Q000502:physiology*; D004745:Enkephalins / Q000138:chemical synthesis; D005768:Gastrointestinal Hormones / Q000138:chemical synthesis; D013007:Growth Hormone-Releasing Hormone / Q000138:chemical synthesis; D006728:Hormones / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007422:Intestines / Q000502:physiology*; D009496:Neurotensin / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*; D011898:Ranidae; D012879:Skin Physiological Phenomena; D013004:Somatostatin / Q000138:chemical synthesis; D013373:Substance P / Q000138:chemical synthesis
D004745:Enkephalins; D005768:Gastrointestinal Hormones; D006728:Hormones; D007202:Indicators and Reagents; D010455:Peptides; D013373:Substance P; D009496:Neurotensin; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone; D001839:Bombesin