Ligustrazine selectively blocks ATP-sensitive K+ channels in mouse pancreatic beta cells.
Ligustrazine potently inhibits hypoxic pulmonary vasoconstriction. This effect can be mimicked by the sulphonylurea tolbutamide, a blocker of ATP-sensitive K+ channels. Here we demonstrate that ligustrazine is a specific blocker of ATP-sensitive K+ channels in mouse pancreatic beta cells. This suggests that ligustrazine may act in the pulmonary circulation by blocking ATP-sensitive K+ channels.
University Laboratory of Physiology, Oxford, England.
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Nye
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003981:Diazoxide / Q000494:pharmacology; D004553:Electric Conductivity; D007515:Islets of Langerhans / Q000502:physiology*; D051379:Mice; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D011719:Pyrazines / Q000494:pharmacology*; D014665:Vasodilator Agents
D015221:Potassium Channels; D011719:Pyrazines; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D003981:Diazoxide; C017953:tetramethylpyrazine