Transcranial Doppler ultrasonographic changes after treatment for arteriovenous malformations.
We performed transcranial Doppler ultrasonography on 15 patients with arteriovenous malformations before and after embolization or surgical resection to compare quantitatively the hemodynamic effects of these two treatments. Changes in mean blood velocity and pulsatility index were analyzed in 19 treated feeding arteries. Blood velocity decreased by a mean of 38.1% or 46.5 cm/sec (p less than 0.0001, two-tailed paired t test); decreases were greater for surgically resected arteries (46.2% or 55.9 cm/sec, p less than 0.003) than for embolized arteries (30.8% or 38.0 cm/sec, p less than 0.0003). Pulsatility index increased by a mean of 54.7% or 0.25 (p = 0.0001); increases were greater for surgically resected arteries (65.8% or 0.29, p = 0.0045) than for embolized arteries (44.8% or 0.20, p less than 0.001). The differences in the changes in blood velocity and pulsatility index between treatment groups were not significant. These data demonstrate that embolization results in hemodynamic changes that are qualitatively similar to those occurring after surgical resection of arteriovenous malformations. Transcranial Doppler ultrasonography is a reliable and convenient noninvasive method for monitoring hemodynamic effects of treatments for arteriovenous malformations.
Department of Neurology, College of Physicians and Surgeons of Columbia University, New York.
G W
GW
Petty
A R
AR
Massaro
T K
TK
Tatemichi
J P
JP
Mohr
S K
SK
Hilal
B M
BM
Stein
R A
RA
Solomon
D I
DI
Duterte
R L
RL
Sacco
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000503:physiopathology / Q000601:surgery; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D008875:Middle Aged; D011674:Pulse; D012886:Skull; D014463:Ultrasonography / Q000379:methods