[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate].
9 patients with postmenopausal and 5 patients with steroid-induced osteoporosis, mean age 57.9 +/- 7.76 years, were treated in the course of one year with sodium fluoride (Fluosen) in a dose of 45 mg/24 h in combination with calcium gluconate (2 g/24 h) and oil solution of vit D2 (2 mg/week). In the course of the treatment a considerable easing of the pains in the most affected parts of the skeleton was found and the height remained at the same level before and after the treatment. This correlates with the statistically significant increase of the serum levels of the total alkaline phosphatase and its bone isoenzyme by keeping a normal kalium phosphorous balance as well as with the x-ray data for retaining the bone changes liked with the osteoporosis.
Todorova
S
S
Diankova
L
L
Andreeva
M
M
Khristova
D
D
Tsachev
K
K
Kamenova
P
P
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D001827:Body Height / Q000187:drug effects; D002125:Calcium Gluconate / Q000627:therapeutic use*; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004872:Ergocalciferols / Q000627:therapeutic use*; D005260:Female; D005942:Gluconates / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D011859:Radiography; D012969:Sodium Fluoride / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D004872:Ergocalciferols; D005942:Gluconates; D012969:Sodium Fluoride; D002125:Calcium Gluconate
Lechenie na bolni s postmenopauzalna i steroidindutsirana osteoporoza s natriev fluorid v kombinatsiia s vitamin D2 i kaltsiev gliukonat.