[Drug-induced dyskinesia during the treatment of Parkinson disease--biochemical studies].
The concentrations of homovanillic acid and 5-hydroxyindoleacetic acid were determined in the cerebrospinal fluid in 17 patients with Parkinson's disease and 10 controls. The patients with Parkinson's disease were on long-term treatment with L-DOPA preparations. In 9 of them drug-induced dyskineses were observed. The HVA/5-HIAA ratio was determined in the cerebrospinal fluid separately in cases with dyskineses, in cases without dyskineses and in controls. It was found that this ratio was significantly higher in patients with drug-induced dyskineses as compared to patients without dyskineses, and especially to controls. It is suggested that this may mean that in cases of drug-induced dyskineses disturbances exist in the equilibrium between the dopaminergic and serotoninergic systems in favour of the former, which may be one of the causes of involuntary movements.
Friedman
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D000368:Aged; D002230:Carbidopa / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000134:cerebrospinal fluid*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D002230:Carbidopa; D006719:Homovanillic Acid
Dyskinezy polekowe w przebiegu leczenia choroby Parkinsona--badania biochemiczne.