Assessment of tumor markers in cerebrospinal fluid.
In clinical practice, the examination of cerebrospinal fluid from patients with primary or metastatic brain tumors is commonly limited to cytomorphologic and routine chemistry analysis. The relative lack of sensitivity and specificity of these tests has led to a search for markers that can detect nervous system involvement by neoplasms at an earlier stage and even predict the site of origin of the neoplasms. This article summarizes recent investigators of biochemical tumor markers and cytoplasmic and cell surface markers in cerebrospinal fluid from patients with nervous system tumors.
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D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000032:analysis; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000556:secondary; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000134:cerebrospinal fluid; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003897:Desmosterol / Q000134:cerebrospinal fluid; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid; D005966:Glucuronidase / Q000134:cerebrospinal fluid; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D008214:Lymphocytes / Q000145:classification; D009363:Neoplasm Proteins / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D010907:Pituitary Hormones / Q000134:cerebrospinal fluid; D011073:Polyamines / Q000134:cerebrospinal fluid; D000509:alpha-Fetoproteins / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005904:Glial Fibrillary Acidic Protein; D007136:Immunoglobulins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D010907:Pituitary Hormones; D011073:Polyamines; D000509:alpha-Fetoproteins; D001613:beta 2-Microglobulin; D003897:Desmosterol; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase