Soluble immune complexes, acute phase proteins and E-rosette inhibitory substance in sera of malnourished children.
The percentage of circulating E-rosetting lymphocytes and the presence of serum E-rosette inhibitory substance were determined in 58 marasmic, 13 kwashiorkor and 22 well-fed children. The blood levels of soluble immune complexes and some acute phase proteins were also measured. The percentage of E-rosetting lymphocytes was significantly higher in the well-fed than in the malnourished children. The presence of the inhibitory substance in serum correlated with depressed levels of circulating mean percentage E-rosetting lymphocytes. Elevation in the level of soluble immune complexes was observed to correlate closely with the presence of serum E-rosette inhibitory substance and with a diminished percentage of E-rosetting lymphocytes. There was no significant correlation between the percentage of circulating E-rosetting lymphocytes and the serum alpha 1 antitrypsin, alpha 2 macroglobulin or C-reactive protein levels. It is suggested that at high serum concentrations soluble immune complexes may bind selectively to human T lymphocytes in vivo, thereby inhibiting the latter's ability to form E-rosettes in vitro.
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D000209:Acute-Phase Proteins; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001798:Blood Proteins; D002097:C-Reactive Protein / Q000378:metabolism; D002675:Child, Preschool; D003176:Complement C3 / Q000097:blood; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000097:blood* / Q000276:immunology; D008077:Lipoproteins, LDL / Q000097:blood*; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000209:Acute-Phase Proteins; D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D003176:Complement C3; D008077:Lipoproteins, LDL; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; C022060:rosette-inhibiting factor; D002097:C-Reactive Protein