Pancreatitis-associated protein in bile acid-induced pancreatitis of the rat.
Experimental pancreatitis was induced in rats by intraductal injection of 0-4% Na-taurocholate. After 0-21 days the glands were removed and amylase, trypsin and chymotrypsin were measured in pancreatic homogenates. The enzyme activities decreased within 48 h to 5-20% of the control values. When 0-1% Na-taurocholate was used, the values tended to increase after 10-21 days. In pancreatic tissue, 12 h after induction of pancreatitis a 'pancreatitis-associated protein' (PAP) was found, which persisted for 4-7 days. A correlation could be found between the severity of pancreatitis and the amount of PAP in pancreatic homogenates.
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D000681:Amylases / Q000032:analysis; D000818:Animals; D001647:Bile Acids and Salts; D005260:Female; D010179:Pancreas / Q000032:analysis; D010195:Pancreatitis / Q000378:metabolism*; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology
D001647:Bile Acids and Salts; D000073718:Pancreatitis-Associated Proteins; D011506:Proteins; C000612141:REG3A protein, human; D012965:Sodium Chloride; D000681:Amylases