Effect of muramyl dipeptide and its stearoyl derivatives on resistance to Sendai virus infection in mice.
The efficacy of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), 6-O-stearoyl-MDP (L18-MDP), N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine (MDP-Lys-L18) and N-stearoylmuramyl-L-alanyl-D-isoglutamine (2N-L18-MDP) for augmenting host-resistance to viral infection was examined in Sendai virus infected mice. L18-MDP and MDP-Lys-L18 augmented the non-specific host-resistance to infection with Sendai virus. MDP showed a slight enhancement of host-resistance to this infection but 2N-L18-MDP was ineffective. The protective effect of MDP-Lys-L18 was seen only when the drug was administered a few days before the virus challenge. The intranasal administration of MDP-Lys-L18 was effective at 1 microgram but only slight activity was observed in mice treated intravenously or intraperitoneally even at the 100 microgram dose level. MDP-Lys-L18 treatment preceding infection augmented interferon production in the lung of the mice but MDP-Lys-L18 treatment alone induced no interferon.
Ishihara
C
C
Hamada
N
N
Yamamoto
K
K
Iida
J
J
Azuma
I
I
Yamamura
Y
Y
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000281:Administration, Intranasal; D000818:Animals; D007110:Immunity, Active; D007113:Immunity, Innate; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis; D008168:Lung / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000276:immunology*; D013329:Structure-Activity Relationship
D007369:Interferon Inducers; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007372:Interferons