[Prevention and treatment of emphysema in the guinea pig with ligustrazine].
This study demonstrated that ligustrazine possesses inhibitory effect obviously on elastic enzyme in vitro, and it can be used to prevent and treat emphysema instead of serum. Using light microscope and electron microscope, the authors observed morphological indexes and analyzed the indexes with stereology and statistics in lung tissues of guinea pigs. The results showed that there was no obvious difference between the ligustrazine administration group and the saline control group as pathological changes were not found in the ligustrazine administration group under microscope. The shapes of elastic proteins were the same under electron microscope observation. Aerosol inhalational method induced emphysema model of elastic enzyme in guinea pig could be improved with ligustrazine treatment.
Wang
G
G
Heilongjiang College of TCM, Harbin.
Tang
Q
Q
Zhu
Y
Y
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D011656:Pulmonary Emphysema / Q000188:drug therapy* / Q000517:prevention & control; D011719:Pyrazines / Q000494:pharmacology / Q000627:therapeutic use*
D011719:Pyrazines; D010196:Pancreatic Elastase; C017953:tetramethylpyrazine