Penetration of 14C-methisoprinol into rabbit eyes with experimentally induced herpetic keratitis.
The authors studied the penetration of 14C-labelled methisoprinol into ocular tissues (cornea, aqueous humour and iris) in rabbits, in which herpetic keratitis had been experimentally induced. It has been demonstrated that the methisoprinol crosses the corneal barrier. The maximum concentration of the drug in the tissues examined was measured 30 min after the instillation of the drug into the conjunctival sac, and persisted for 60 min, although at a slightly lower level.
Alberghina
M
M
Tognon
M
M
Cassai
E
E
Gorgone
G
G
Cavallaro
N
N
Filippello
M
M
Scaletta
S
S
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005260:Female; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000378:metabolism* / Q000627:therapeutic use; D007498:Iris / Q000378:metabolism; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000378:metabolism*; D009883:Ophthalmic Solutions; D011817:Rabbits
D009883:Ophthalmic Solutions; D007288:Inosine; D007542:Inosine Pranobex