Genotoxic potency of monofunctional alkylating agents in E. coli: comparison with carcinogenic potency in rodents.
A quantitative correlation between carcinogenicity and genotoxicity was investigated by a comparison between the carcinogenic potency in rodents and the mutagenic (M), recombinogenic (R) and SOS-inducing (I) potencies in a bacterial test (E. coli multitest) for 9 monofunctional alkylating agents: N-nitroso-N-methylurethane, N-nitroso-N-ethylurea, epichlorohydrin, N-nitroso-N-methylurea, N-nitroso-N-methyl-N'-nitroguanidine, methyl methanesulfonate, diethylsulfate, dimethylsulfate, ethyl methanesulfonate. A significant positive correlation between the carcinogenic potency and the product of the mutagenic and recombinogenic potencies was found for all tested compounds. Thus, the E. coli multitest may be used as a simple test to search for correlations between carcinogenicity and genotoxicity of DNA-damaging agents.
Department of Molecular Biology, Free University of Brussels, Belgium.
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I
Quinto
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L
Tenenbaum
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M
Radman
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D011995:Recombination, Genetic; D012377:Rodentia / Q000235:genetics; D013014:SOS Response, Genetics
D000477:Alkylating Agents; D009153:Mutagens