Relationship between preoperative status of the fibrinolytic system and occurrence of deep vein thrombosis after major abdominal surgery.
This study comprised 50 patients subjected to major abdominal surgery, of which 13 developed deep vein thrombosis (DVT) according to the 125I-fibrinogen test. Plasma was sampled preoperatively, for the specific analysis of tissue plasminogen activator (t-PA) before and during venous occlusion. The recently described fast t-PA inhibitor and plasmin alpha 2-antiplasmin complex (PAP) were also measured. The result of the laboratory analyses were correlated to the development of DVT. From the data obtained it is concluded that the evaluation of t-PA release during venous occlusion is a poor predictive factor for the occurrence of DVT after major abdominal surgery. The level of the t-PA inhibitor appears to be raised in these patients, but the values obtained in this material were not related to the development of postoperative DVT. Patients with elevated PAP levels, as shown previously, have a lesser tendency to develop postoperative DVT.
Mellbring
G
G
Dahlgren
S
S
Wiman
B
B
Sunnegårdh
O
O
D000328:Adult; D013505:Digestive System Surgical Procedures; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000097:blood; D005342:Fibrinolysis; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors / Q000378:metabolism; D015849:Plasminogen Inactivators; D011183:Postoperative Complications / Q000209:etiology*; D011480:Protease Inhibitors / Q000097:blood; D013924:Thrombophlebitis / Q000209:etiology*; D000511:alpha-Macroglobulins / Q000097:blood
D006023:Glycoproteins; D015849:Plasminogen Inactivators; D011480:Protease Inhibitors; D000511:alpha-Macroglobulins; D010960:Plasminogen Activators; D005341:Fibrinolysin