Cutaneous interstitial fluid protein concentrations in the inflammatory syndrome: pharmacological consequences.
Concentrations of alpha 1 acid glycoprotein, albumin, transferrin, haptoglobin, immunoglobulins G, A, M and apolipoprotein B were measured in serum and suction blister fluid from a group of individuals presenting a biologically proven inflammatory syndrome, and from a control group. Protein values in suction blister fluid did not change from the 2nd to the 3rd h after the beginning of blister formation. The ratio of the concentration of proteins in blister fluid and serum did not differ significantly between the groups. However, a 25% decrease in blister fluid albumin and a 100% increase in blister fluid alpha 1 acid glycoprotein, recorded in the inflammatory group, were worth noting, since they possibly influence the tissular distribution of some protein-binding drugs. Finally, an inverse relationship was established between the blister fluid/serum concentration ratio and the respective molar mass of each protein.
Service de Biochimie A, Hotel-Dieu, Rennes, France.
C
C
Clerc
M
M
Pibouin
A
A
Ruelland
B
B
Legras
J
J
Chevrant-Breton
L
L
Cloarec
D000368:Aged; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010599:Pharmacokinetics; D011485:Protein Binding; D011506:Proteins / Q000032:analysis* / Q000378:metabolism; D012867:Skin / Q000032:analysis* / Q000378:metabolism
D011506:Proteins