Human cellular immune response to copolymer I and myelin basic protein.
Copolymer I (Cop I) is being tested as a treatment for MS because it protects animals against experimental allergic encephalomyelitis, and because there is immunologic cross-reactivity reported between Cop I and myelin basic protein (MBP). From the peripheral blood mononuclear cells of four normal individuals, we isolated helper-phenotype T-cell lines that reacted in vitro with Cop I or MBP. Cop I-reactive cell lines did not respond to MBP, nor did MBP-reactive T-cell lines respond to Cop I. Antigen-specific immune tolerance was induced in MBP-reactive cell lines by exposure to MBP in vitro, but similar exposure to Cop I did not induce tolerance in the MBP-reactive cell lines. We found no evidence of immunologic cross-reactivity between Cop I and MBP.
Burns
J
J
Krasner
L J
LJ
Guerrero
F
F
D000818:Animals; D000917:Antibody Formation; D002460:Cell Line; D003429:Cross Reactions; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000196:embryology; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D004676:Myelin Basic Protein; D010455:Peptides; C021759:(T,G)-A-L