Serum and tissue tumour markers in seminomas.
The serum expression of the tumour markers hydroxybutyric dehydrogenase (HBD), beta human chorionic gonadotrophin (beta HCG), alphafetoprotein (alpha FP) and placental alkaline phosphatase (PLAP) has been assessed in a consecutive series of 50 patients with pure seminoma. In pre-orchiectomy sera from 15 patients with stage I disease, HBD was elevated in 5, beta HCG in 3, alpha FP in 1 and PLAP in 1 (of 3 only). In 27 patients with stage 2 or 3 disease, prior to chemotherapy, serum HBD was elevated in 19, beta HCG in 11, alpha FP in 2 and PLAP in 10 (of 18). The presence of beta HCG was investigated immunocytochemically in primary tumour tissue from 39 patients. It was demonstrated in 6 of 21 tumours from patients with stage I disease and 5 of 18 with stage 2 or 3 disease.
T F
TF
Ford
D N
DN
Butcher
C T
CT
Samuell
J R
JR
Masters
M C
MC
Parkinson
R T
RT
Oliver
D000469:Alkaline Phosphatase / Q000097:blood; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000378:metabolism*; D058851:GPI-Linked Proteins; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008297:Male; D009362:Neoplasm Metastasis; D010446:Peptide Fragments / Q000032:analysis / Q000097:blood; D013736:Testicular Neoplasms / Q000378:metabolism*; D000509:alpha-Fetoproteins / Q000097:blood
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D010446:Peptide Fragments; D000509:alpha-Fetoproteins; D006884:Hydroxybutyrate Dehydrogenase; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental