Mouse skin bioassay of smoke condensates from cigarettes containing different levels of cocoa.
Smoke condensates derived from three cigarette types of identical blend to which 0, 1 and 3% cocoa powder was added to the filler were assayed on mice by chronic dermal application (skin painting). For each cigarette type, three condensate doses were applied: 60, 90 and 125 mg dry condensate/mouse/week. The results obtained in this study do not provide evidence that the biological activity of the condensates, as indicated by the occurrence of non-tumorous and tumorous lesions, is enhanced by the addition of cocoa.
Roemer
E
E
INBIFO Institute für biologische Forschung, Köln, Federal Republic of Germany.
Hackenberg
U
U
D000818:Animals; D002099:Cacao / Q000633:toxicity*; D015197:Carcinogenicity Tests; D005260:Female; D051379:Mice; D010945:Plants, Edible; D010947:Plants, Toxic; D012871:Skin Diseases / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology*; D012906:Smoke / Q000009:adverse effects*; D013997:Time Factors; D014026:Nicotiana
D012906:Smoke