Concentrations of murinoglobulin and alpha-macroglobulin in the mouse serum: variations with age, sex, strain, and experimental inflammation.
Serum levels of murinoglobulin and alpha-macroglobulin were low in newborn mice but increased during the prepubertal development. The adult levels of the two inhibitors were higher in males than in females in 8 inbred strains tested. Gonadectomy at 2 w of age did not significantly affect the prepubertal rise in the levels not only of the above two inhibitors but of contrapsin and alpha-1-antiprotease. The gonadectomy, however, abolished the sex differences seen in the adult levels of these inhibitors. The levels of murinoglobulin and alpha-macroglobulin reached their minimum at 12 h after inducing inflammation and returned to normal at 24 h. Little change was observed in the levels of contrapsin and alpha-1-antiprotease under the same inflammatory conditions.
K
K
Yamamoto
Y
Y
Tsujino
A
A
Saito
H
H
Sinohara
D000367:Age Factors; D000818:Animals; D001798:Blood Proteins; D005260:Female; D007249:Inflammation / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D015843:Serpins; D012712:Serum Globulins / Q000378:metabolism*; D012737:Sex Factors; D013045:Species Specificity; D014361:Trypsin Inhibitors / Q000097:blood; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins / Q000378:metabolism*
D001798:Blood Proteins; D015843:Serpins; D012712:Serum Globulins; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; C044177:murinoglobulin; C033691:contrapsin