Tachykinin responses in the rat cingulate cortex: a comparison of the effects of iontophoretically applied substance P and neurokinin A.
The effects of substance P and neurokinin A were compared on spontaneously active cells in the anterior cingulate cortex of the rat. Most neurones were strongly excited by the iontophoretic applications of both peptides. However, many of the superficially located cells were clearly depressed by substance P but unaffected by the application of neurokinin A or even weakly excited. The results indicate that neuronal responses to tachykinins in this brain area may be mediated, at least in part, by separate receptors.
Jones
R S
RS
Olpe
H R
HR
D000818:Animals; D006179:Gyrus Cinguli / Q000378:metabolism*; D007478:Iontophoresis; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000494:pharmacology*; D015288:Neurokinin A; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013373:Substance P / Q000494:pharmacology*; D015320:Tachykinins
D009419:Nerve Tissue Proteins; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A