A new duplication C4B*1,12 at the C4B locus associated with BF*S07 in a Tunisian population.
Twenty-five Tunisian families were analyzed for their complement alleles in order to detect duplications at the C4 loci. In this population, the most characteristic duplications are C4A2, B1.12 or C4A1, B1,12 always associated with BFS07 and C2C. This previously undescribed C4B1,12 duplication was found in seven families, five times in association with HLA-A2, B50.
Gorgi
Y
Y
Immunology Laboratory, Tunis, Tunisia.
Arnold
D
D
Uring-Lambert
B
B
Bardi
R
R
Ayed
K
K
Hauptmann
G
G
D000483:Alleles; D002874:Chromosome Mapping; D003175:Complement C2 / Q000235:genetics / Q000276:immunology; D003181:Complement C4 / Q000235:genetics / Q000276:immunology; D015935:Complement C4b / Q000235:genetics* / Q000276:immunology; D011415:Complement Factor B / Q000235:genetics / Q000276:immunology; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D005810:Multigene Family; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics / Q000276:immunology; D012699:Serology; D014416:Tunisia
D003175:Complement C2; D003181:Complement C4; D015935:Complement C4b; D011415:Complement Factor B