Administration of N-nitrosodimethylamine, N-nitrosopyrrolidine, or N'-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings.
When nursing Sprague-Dawley rats were treated with [14C]N-nitrosodimethylamine [(NDMA) CAS: 62-75-9], N-nitrosopyrrolidine (CAS:930-55-2), or N'-nitrosonornicotine (CAS: 16543-55-8), the liver and kidney DNA from their 14-day-old offspring that had been nursed over a 24-hour period became labeled. Upon analysis, liver DNA from sucklings whose nursing mothers were treated with [14C]NDMA showed N7-methylguanine- and O6-methylguanine-altered bases. The results suggest that these nitrosamines, which are present in food, tobacco smoke, and in different environmental sources, are a risk not only for lactating mothers but also for the nursing infants.
M I
MI
Díaz Gómez
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D
Tamayo
J A
JA
Castro
D000478:Alkylation; D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D002250:Carbon Radioisotopes; D004247:DNA / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D009242:N-Nitrosopyrrolidine / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D009602:Nitrosamines; D009696:Nucleic Acids; D012313:RNA; D004247:DNA; D004128:Dimethylnitrosamine; D009242:N-Nitrosopyrrolidine; C008655:N'-nitrosonornicotine