Contribution of measles virus fusion protein in protective immunity: anti-F monoclonal antibodies neutralize virus infectivity and protect mice against challenge.
To study the contribution of the measles virus fusion (F) protein in the immune response, anti-F monoclonal antibodies were prepared by using a vaccinia-measles virus F recombinant. In contrast to previously described anti-F monoclonal antibodies, these antibodies not only neutralized virus infectivity and inhibited fusion but also passively protected mice. Since these monoclonal antibodies recognize a configurational epitope, presentation of the antigen during infection may play an important role in the immune response. These factors are discussed in relation to vaccination.
Malvoisin
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Immuno-Virologie Moléculaire et Cellulaire UMR 30, Centre National de la Recherche Scientifique, Faculté de Médecine Alexis Carrel, Lyon, France.
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F
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D007116:Immunization, Passive; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D014760:Viral Fusion Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D014760:Viral Fusion Proteins