[The effect of arginine vasopressin and its derivatives on the brain neurons of the edible snail].
Neuronal responses induced by application or perfusion of solutions with arginine vasopressin and its derivatives (VPS) have been examined on identified Helix pomatia neurons. No differences between VPS-induced effects were obtained. Depolarizing, hyperpolarizing and modulatory neuronal responses were found. De- and hyperpolarizing responses were due to an increase and a decrease in permeability of the surface neuronal membrane, respectively. The reversal potential of both responses was near the chloride equilibrium potential and was inhibited by furosemide. It is supposed that VPS-induced responses are associated with an increase and a decrease in permeability of chloride ions of the surface neuronal membrane. A modulatory VPS response is an increase of the current amplitude induced by intracellular cAMP injection by VPS perfusion. It is supposed that some Helix pomatia neurons have different receptors to VPS which, probably, are associated with the system of cyclic nucleotides.
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Osipenko
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D005665:Furosemide / Q000494:pharmacology; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology
D001127:Arginine Vasopressin; D005665:Furosemide
Vliianie arginin-vazopressina i ego proizvodnykh na neĭrony mozga vinogradnoĭ ulitki.