Rhythmic coma in children.
We describe a syndrome of rhythmic coma in children that consists of an invariant, nonreactive, diffuse cortical activity of a specific frequency, such as alpha, beta, spindle, or theta, recorded from a comatose child. We report 11 cases of children who were found to be in rhythmic coma during their acute illnesses. Their ages ranged from 2 to 15 years, and their diagnoses included encephalitis, head trauma, seizures, near drowning, brain tumors, stroke, and metabolic derangements. The specific frequency of the electroencephalographic pattern, ie, alpha, beta, spindle, or theta, did not influence the outcome. The clinical outcome appeared to depend on the primary disease process rather than the electroencephalographic finding. The prognosis of alpha-frequency rhythmic coma as well as of rhythmic coma in general was better in children than in adults. The pathophysiology in children may be similar, ie, the interruption of reticulothalamocortical pathways by metabolic or structural abnormalities, but the expression of this deafferentation may be more varied in the developing brain. Thus, we propose the term rhythmic coma as a unified concept for alpha, beta, spindle, and theta coma in children.
Division of Neurology, Children's Hospital of Los Angeles, CA 90027.
E J
EJ
Horton
W D
WD
Goldie
T Z
TZ
Baram
D000293:Adolescent; D000513:Alpha Rhythm; D001611:Beta Rhythm; D001925:Brain Damage, Chronic / Q000503:physiopathology; D001930:Brain Injuries / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000503:physiopathology*; D004569:Electroencephalography; D004660:Encephalitis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D011379:Prognosis; D013826:Theta Rhythm