[Effect of Na+, K+ and Ca++ ions on catecholamine release in the caudal mesenteric ganglion].
In isolated superfused caudal mesenteric ganglions of dogs, release of adrenaline (A) and noradrenaline (NA) under the effect of stimulation of lumbar splanchnic and subsplanchnic nerves and acetylcholine administration was studied during pharmacological blockade of ion-selective channels and main ions deprivation. Removal of Na+ or K+ increased the release of A and NA whereas Ca++ deprivation reduced it. Blockade of Na+ channels sharply increased the amount of released A and NA. Blockade of Ca++ conduction eliminated completely all kinds of the catecholamines release. Addition of ouabain induced the A and NA release. Both verapamil and ouabain increased the A and NA release in response to the nerves stimulation and acetylcholine administration.
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004285:Dogs; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000502:physiology*; D012964:Sodium / Q000502:physiology*; D013153:Splanchnic Nerves / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D007473:Ion Channels; D010042:Ouabain; D012964:Sodium; D014700:Verapamil; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine
Vliianie ionov Na+, K+ i Ca++ na vysvobozhdenie katekholaminov v kaudal'nom bryzheechnom ganglii.