Immunological tolerance in human transplantation. The possible existence of a maternal effect.
We analyzed data from 93 patients who received a kidney graft from their parents; 55 were transplanted with a kidney from their mothers (Mat.) and thirty-eight from their fathers (Pat.) The Pat. group has shown a better graft and patient survival as well as long-term renal function when compared with the Mat. group. This pattern was more evident with time. Long-term graft function assessed by creatinine levels also showed differences between the groups, favoring the Pat. group. The results are interesting since recent reports have claimed a tolerance developed by the individual to noninherited HLA antigens of their mother.
Panajotopoulos
N
N
Laboratory of Transplantation Immunology, Faculty of Medicine, University of São Paulo, Brazil.
Ianhez
L E
LE
Neumann
J
J
Sabbaga
E
E
Kalil
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation / Q000276:immunology; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D008875:Middle Aged; D011247:Pregnancy; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000276:immunology* / Q000401:mortality