Influence of thyroid function upon "Substance P" induced secretion of saliva by submaxillary glands.
The effects of changes in thyroid function on the action of "Substance P" upon the secretion of saliva by the submaxillary glands was studied in male Wistar rats, with parasympathetic decentralization on the left side. The dose-response curves to increasing doses of "Substance P" showed in hyperthyroid animals increased salivary secretion while in hypothyroid animals the dose-response curve to the drug was decreased. Every animal showed supersentivity to "Substance P" in the decentralized gland. The influence of changes in thyroid function in the denervated glands was the same as that in the unoperated side, increased salivary secretion in hyperthyroidism and decreased in hypothyroidism.
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Tumilasci
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AB
Houssay
C del V
Cdel V
Paz
N E
NE
Sosto
V
V
Varela
D000818:Animals; D003714:Denervation; D004305:Dose-Response Relationship, Drug; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*; D013961:Thyroid Gland / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology
D010446:Peptide Fragments; D014284:Triiodothyronine; D013373:Substance P; C032682:substance P (4-11)