Bacterial lipopeptides induce ion-conducting pores in planar bilayers.
Bacterial lipopeptides, known for their antibiotic activities, have been tested for their ability to interact with lipid membranes. These lipopeptides, Iturin A, Bacillomycin L and D and Peptidolipin NA present analogous structural characteristics: a heptapeptidic cycle is linked to a hydrocarbon chain. We present evidence that these lipopeptides modify the conductance of planar bilayers by forming ion-conducting pores.
R
R
Maget-Dana
F
F
Heitz
M
M
Ptak
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F
Peypoux
M
M
Guinand
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D007473:Ion Channels / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism*; D055666:Lipopeptides; D008074:Lipoproteins / Q000378:metabolism*; D008564:Membrane Potentials; D010455:Peptides; D010456:Peptides, Cyclic / Q000378:metabolism; D013997:Time Factors
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D007473:Ion Channels; D008051:Lipid Bilayers; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; D010456:Peptides, Cyclic; C025801:peptidolipin NA; C013579:iturin A; C015015:bacillomycin L; C027845:bacillomycin D