[Characterization of chromosomal aberrations induced in man by various antimitotic agents].
Six antitumoral drugs were tested in human lymphocytes cultures. Our observations pointed out specific abnormalities beside more usual chromosomal aberrations. These lesions are mainly telomeric and chromatidic fusions, chromomerisations and despiralizations. We present an interpretation of these abnormalities.
Turchini
M F
MF
Geneix
A
A
Perissel
B
B
Malet
P
P
Turchini
J P
JP
D000970:Antineoplastic Agents / Q000633:toxicity*; D001578:Benzopyrans / Q000633:toxicity; D001761:Bleomycin / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000633:toxicity; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D008938:Mitosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D013713:Teniposide / Q000633:toxicity; D014751:Vindesine / Q000633:toxicity
D000970:Antineoplastic Agents; D001578:Benzopyrans; D008937:Mitomycins; D001761:Bleomycin; C012718:amikhellin; D016685:Mitomycin; D013713:Teniposide; D002945:Cisplatin; D014751:Vindesine
Typologie d'aberrations chromosomiques induites chez l'Homme par différents antimitotiques.