[Correction of microcirculatory disorders in rheumatic diseases].
The present article is concerned with the problems of pharmacotherapy of microcirculatory disorders (MD) in rheumatic diseases (RD) and with the complex of methods permitting one to judge the intensity of the pathological process at the microcirculatory level. Based on the study of the problems of the correction of MD in more than 300 patients with RD the vasospastic, ischemic, cutaneotrophic, renal and pulmorenal syndromes as well as the DIC syndrome were recognized which require the correction therapy. Differentiated therapy including heparin, deaggregating agents, rheopolyglucin and peripheral vasodilators should be performed with regard to the degree of blood rheological properties derangement and tendency of alterations in the hemostatic potential. To evaluate the treatment, efficacy, biomicroscopy of the vessels of the eyeball conjunctiva and laboratory standardized methods for hemostasis study are the most available techniques.
Guseva
N G
NG
Poltyrev
A S
AS
Alekseev
V I
VI
Anikina
N V
NV
Shcherbakov
A B
AB
D000284:Administration, Oral; D002986:Clinical Trials as Topic; D003911:Dextrans / Q000008:administration & dosage; D004176:Dipyridamole / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009543:Nifedipine / Q000008:administration & dosage; D011928:Raynaud Disease / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000150:complications*
D003911:Dextrans; D004176:Dipyridamole; D006493:Heparin; D009543:Nifedipine
Korrektsiia narusheniia mikrotsirkuliatsii pri revmaticheskikh zabolevaniiakh.