Phase I study of MVE-2 evaluating toxicity and biologic response modification capability.
A total of 21 patients were treated in a phase I trial using the biological response modifier MVE-2, a low molecular weight component of pyran copolymer. All patients received weekly IV MVE-2 infused over 2 h. Proteinuria, sometimes of nephrotic proportions, was the dose limiting toxicity, and was seen with increasing incidence as the cumulative dose of MVE-2 exceeded 2500 mg. Other toxicity with MVE-2 was minimal. Biologic response modification at tolerable doses was inconsistent, although several assays, particularly natural cell-mediated cytotoxicity, indicated enhanced activity at higher dosages of MVE-2. No objective tumor responses were observed. MVE-2 is not useful as a biological response modifier using our initial method of administration, since the dose limiting toxicity occurred at lower levels than were necessary to induce consistent biologic response modification. Following completion of the phase I study, we administered MVE-2 by 30-min infusion to 8 additional patients and did not detect proteinuria, in spite of large cumulative doses. It is possible that alternate schedules of MVE-2 administration could minimize proteinuria and allow the administration of dosages necessary for immunologic modification.
J D
JD
Hainsworth
J T
JT
Forbes
W W
WW
Grosh
F A
FA
Greco
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004361:Drug Tolerance; D006801:Humans; D007263:Infusions, Parenteral; D007372:Interferons / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D011108:Polymers / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced; D011713:Pyran Copolymer / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D011108:Polymers; D011713:Pyran Copolymer; D007372:Interferons