SLO4, a new interferon inducer isolated from Klebsiella pneumoniae and Escherichia coli.
A product isolated from Klebsiella pneumoniae and Escherichia coli, coded SLO4, has been shown to be effective in endogenous interferon induction in vivo in mouse when administered IP or IV, and in vitro with human leukocyte cultures. In these two systems induced interferon was defined. The inducer has not yet been characterized but seems not to belong to any components known to be interferon inducers such as viral particles, nucleic acids or endotoxins. An analytical study will be carried out to specify the constitution of this interferon inducer.
Stefanos
S
S
Vanderhoven
C
C
Wietzerbin
J
J
Falcoff
R
R
Page
Y
Y
D000818:Animals; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006801:Humans; D007369:Interferon Inducers / Q000302:isolation & purification*; D007372:Interferons / Q000276:immunology; D007711:Klebsiella pneumoniae / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D007369:Interferon Inducers; D007372:Interferons