Autoantibodies and their relation to rheumatic diseases.
The use of tissue culture substrates for immunofluorescence determinations of nuclear, cytoplasmic, and mitotic cell-related autoantibodies has resulted in the delineation of diverse new specificities, whose clinical correlates are now becoming apparent. This review details both major and minor autoantibody specificities, the status of knowledge regarding their target antigens, and the relation of these serologic systems to distinctive rheumatic disease syndromes.
McCarty
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D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D002466:Cell Nucleolus / Q000378:metabolism; D002503:Centromere / Q000276:immunology; D004247:DNA / Q000276:immunology; D004264:DNA Topoisomerases, Type I; D004277:DNA, Single-Stranded / Q000276:immunology; D003852:Deoxyribonucleoproteins / Q000276:immunology; D003882:Dermatomyositis / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006657:Histones / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008403:Mass Screening; D009220:Myositis / Q000276:immunology; D009687:Nuclear Proteins; D009698:Nucleoproteins / Q000276:immunology; D010743:Phospholipids / Q000276:immunology; D012313:RNA / Q000276:immunology / Q000378:metabolism; D020733:RNA, Small Cytoplasmic; D012216:Rheumatic Diseases / Q000175:diagnosis*; D012261:Ribonucleoproteins / Q000276:immunology; D017411:Ribonucleoproteins, Small Nuclear; D012595:Scleroderma, Systemic / Q000276:immunology; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001323:Autoantibodies; D001324:Autoantigens; D004247:DNA; D004264:DNA Topoisomerases, Type I; D004277:DNA, Single-Stranded; D003852:Deoxyribonucleoproteins; D006657:Histones; D009687:Nuclear Proteins; D009698:Nucleoproteins; D010743:Phospholipids; D012313:RNA; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human; C048100:Scl 70 antigen, human