Formation of transmembrane channels in liposomes during injection of lambda DNA.
Bacteriophage lambda binds to unilamellar liposomes bearing its receptor protein, LamB, and the lambda DNA can be injected into the internal aqueous space. During this process, transmembrane channels are formed in the liposomes which permit the entry and escape of small molecules, but not proteins. The channels are stable and persist after DNA injection.
C A
CA
Roessner
G M
GM
Ihler
D000255:Adenosine Triphosphate / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D010582:Bacteriophage lambda / Q000235:genetics*; D004279:DNA, Viral / Q000378:metabolism*; D007473:Ion Channels / Q000032:analysis*; D008081:Liposomes / Q000032:analysis*; D008854:Microscopy, Electron; D011991:Receptors, Virus / Q000378:metabolism; D013997:Time Factors
D004279:DNA, Viral; D007473:Ion Channels; D008081:Liposomes; D011991:Receptors, Virus; D000255:Adenosine Triphosphate; D000469:Alkaline Phosphatase