The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34;q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor alpha/delta chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.
Carroll
A J
AJ
University of Alabama, Birmingham.
Crist
W M
WM
Link
M P
MP
Amylon
M D
MD
Pullen
D J
DJ
Ragab
A H
AH
Buchanan
G R
GR
Wimmer
R S
RS
Vietti
T J
TJ
D000293:Adolescent; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D011995:Recombination, Genetic; D013950:Thymus Gland / Q000166:cytology; D014178:Translocation, Genetic / Q000235:genetics*
D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell