Retinal pigment epithelial cells release an inhibitor of neovascularization.
Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.
Glaser
B M
BM
Campochiaro
P A
PA
Davis
J L
JL
Sato
M
M
D020533:Angiogenesis Inhibitors; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000196:embryology; D001253:Astrocytes / Q000378:metabolism; D002417:Cattle / Q000196:embryology; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003315:Cornea / Q000166:cytology / Q000187:drug effects; D003470:Culture Media; D004847:Epithelial Cells; D005333:Fetus / Q000033:anatomy & histology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010857:Pigment Epithelium of Eye / Q000032:analysis / Q000166:cytology / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D012160:Retina / Q000032:analysis; D014020:Tissue Extracts / Q000494:pharmacology; D015017:Yolk Sac / Q000098:blood supply
D020533:Angiogenesis Inhibitors; D003470:Culture Media; D011506:Proteins; D014020:Tissue Extracts