[Antigenicity of alumina ceramic and calcium phosphate ceramics--genetic control of the immune response].
Antigenicity of alumina ceramic, hydroxyapatite ceramic and tricalcium phosphate ceramic was studied by induction of footpad swelling in C57BL/6 mice immunized by ceramics with Freund's complete adjuvant. Significant footpad swelling was observed in mice immunized with tricalcium phosphate ceramic at 2 and 4 weeks after immunization. Antigenic specificity was demonstrated between tricalcium phosphate ceramic and fetal bovine serum in crisscross. Time course of the reaction suggested that delayed-type hypersensitivity played an important role in footpad swelling. These results indicate that tricalcium phosphate ceramic has antigenicity to C57BL/6 mice. Antigenicity of alumina ceramic and hydroxyapatite ceramic was not demonstrated in this study. A positive footpad reaction to tricalcium phosphate ceramic was shown in C57BL/10 (H-2b) and C57BL/10 X BR (H-2k), but was not observed in C57BL/10 X D2(H-2d). These results suggest that this response to tricalcium phosphate ceramic was under control by a gene located within the major histocompatibility complex.
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D000535:Aluminum / Q000276:immunology*; D000537:Aluminum Oxide / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000276:immunology*; D001672:Biocompatible Materials; D002130:Calcium Phosphates / Q000276:immunology*; D002516:Ceramics; D000939:Epitopes; D005802:Genes, MHC Class II; D006882:Hydroxyapatites / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007156:Immunologic Memory; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*
D000941:Antigens; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D000939:Epitopes; D006882:Hydroxyapatites; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000535:Aluminum; C485829:calcium phosphate, dibasic, anhydrous; D000537:Aluminum Oxide