Native alpha 2-macroglobulin binds to a surface component of human placental trophoblast.
Immunofluorescence and radiobinding studies have shown that native human alpha 2-macroglobulin (alpha 2M), but not alpha 2M-trypsin complexes, binds to isolated human placental syncytiotrophoblast microvillous plasma membrane vesicles. Inhibition studies have indicated that alpha 2M may bind to a trophoblast surface protease. This interaction is of significance for the control of trophoblast invasiveness and haemostasis within the placental bed.
P M
PM
Johnson
P
P
Arnaud
P
P
Werner
R M
RM
Galbraith
D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007457:Iodine Radioisotopes; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D007457:Iodine Radioisotopes; D000511:alpha-Macroglobulins