Quantitative microfocal radiography of children with renal osteodystrophy; comparison with laboratory and histological findings.
High definition microfocal radiography permitted the quantitative assessment of the radiographic features of renal osteodystrophy in the phalanges of 11 children in stable chronic renal failure, treated with phosphate binders for 1 year. The most consistent feature was subperiosteal cortical resorption, expressed as a ratio total length of resorbed subperiosteal bone/total length subperiosteal bone x 100. It was found that the extent of resorbed bone was significantly greater in the middle phalanx and on the ulnar surface of the phalanges. The radiological findings over the duration of the disease were compared with laboratory assessments and bone histomorphometry. The extent of the percentage of subperiosteal resorption at base line and its change during the study period correlated significantly with the level of serum parathyroid hormone levels and its change over the same period. No other significant correlations were found between radiographic features and laboratory assessments or with bone histomorphometry.
Anatomy Department, Guy's Hospital Medical School, London.
J C
JC
Buckland-Wright
M W
MW
Spring
R H
RH
Mak
C
C
Turner
J
J
Compston
S
S
Vedi
G B
GB
Haycock
C
C
Chantler
D000293:Adolescent; D001862:Bone Resorption / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D005385:Fingers / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008852:Microradiography / Q000379:methods; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone