Syntheses, antiinflammatory, and analgesic activities of arylbiurets.
A number of arylbiurets were prepared and evaluated as antiinflammatory and analgesic agents by using the carrageenan paw edema and acetic acid stretching tests. Among them, the antiinflammatory activity of 1,3-dimethyl-5-phenylbiuret (7), 1-ethyl-3-methyl-5-phenylbiuret (11), and 1,1,3-trimethyl-5-phenylbiuret (13) were found to be more potent than phenylbutazone. The analgesic activity of 7 and of 5-(4-chlorophenyl)-1,1,3-trimethylphenylbiuret (16) is higher than that of aminopyrine.
Chemical Synthesis Research Laboratory, Taiho Pharmaceutical Company, Ltd., Saitama, Japan.
M
M
Kajitani
T
T
Yamazaki
S
S
Yamada
M
M
Tanaka
K
K
Ogawa
T
T
Honna
H
H
Miyake
T
T
Yabuuchi
H
H
Fujimura
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001737:Biuret / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000031:analogs & derivatives*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001737:Biuret; D014508:Urea