Studies on cell-mediated immune response to rabies virus immunization in dogs.
Peripheral blood leucocytes (PBL) from unvaccinated dogs and dogs vaccinated subcutaneously with beta-propiolactone (BPL) inactivated sheep brain antirabies vaccine were exposed in vitro to rabies antigen. A direct leucocyte migration inhibition (LMI) assay in agarose was used to study the cell-mediated immune (CMI) response. The CMI response could be detected as early as 7 days postvaccination. It reached a peak by 14 days postvaccination followed by a decline. The PBL from unvaccinated control dogs were not stimulated by rabies virus antigen.
Department of Preventive Medicine, Madras Veterinary College, India.
R
R
Jayakumar
P
P
Ramadass
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D004285:Dogs; D007111:Immunity, Cellular / Q000502:physiology*; D007115:Immunization Schedule; D011818:Rabies / Q000517:prevention & control; D011819:Rabies Vaccines / Q000276:immunology / Q000627:therapeutic use*; D011820:Rabies virus / Q000276:immunology; D012756:Sheep; D014611:Vaccination
D000956:Antigens, Viral; D011819:Rabies Vaccines