Radiolabeled antibodies: results and potential in cancer therapy.
Radiolabeled antibodies are analyzed from the classical approach in radiation oncology being compared to geometric isotopic implants, external radiation, and tumor-dose response and energy of the isotope used for cytotoxicity. In addition, physiological factors that limit antibody uptake, varied routes of administration, toxicity of treatment, as well as present clinical progress are reviewed.
Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, Maryland 21205.
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D000912:Antibodies, Neoplasm / Q000276:immunology*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011868:Radioisotopes / Q000008:administration & dosage*; D011879:Radiotherapy Dosage
D000912:Antibodies, Neoplasm; D011868:Radioisotopes