Tachykinin modulation of coronary blood flow.
In pentobarbital anesthetized, open chest pigs, coronary blood flow (CBF), myocardial contractility and systemic hemodynamic variables were monitored during intracoronary injections of substance P (SP), neurokinin A (NA) or neurokinin B (NB). SP was most potent in increasing CBF although NA was also active in high doses while NB had absolutely no effect. SP was also more potent than NA in producing systemic hypotension. The data suggests that SP and its receptors might be potentially important modulators of CBF.
Ezra
D
D
Laurindo
F R
FR
Eimerl
J
J
Goldstein
R E
RE
Peck
C C
CC
Feuerstein
G
G
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D015288:Neurokinin A; D015287:Neurokinin B; D009842:Oligopeptides / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D013552:Swine; D015320:Tachykinins
D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B