A human IgG1-K type M-protein with antibody activity against horse and rabbit alpha 2-macroglobulin.
A human IgG1-K type M-protein which specifically precipitates with alpha 2-macroglobulin (alpha 2-M) from horse and rabbit is described. This protein did not combine with human alpha 2-M nor with alpha 2-M from various other species. The binding activity was exclusively located in the Fab region of the molecule. This patient had never received injection of horse anti-tetanus serum. The present case seems to be the second report of an M-protein with antibody activity against horse and rabbit alpha 2-M.
Fujita
K
K
Sakurabayashi
I
I
Kawai
T
T
Sato
T
T
D000368:Aged; D000818:Animals; D001798:Blood Proteins / Q000276:immunology*; D004588:Electrophoresis, Cellulose Acetate; D006736:Horses; D006801:Humans; D007122:Immunoelectrophoresis; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007136:Immunoglobulins; D008297:Male; D008970:Molecular Weight; D009194:Myeloma Proteins / Q000276:immunology; D011817:Rabbits; D000511:alpha-Macroglobulins / Q000276:immunology*
D001798:Blood Proteins; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D009194:Myeloma Proteins; D000511:alpha-Macroglobulins