The effects of administration of drugs influencing haemostasis during treatment of patients with burns.
The administration of drugs influencing disordered haemostasis (heparin, nicotinic acid, thrental, phytin and alpha-tocopherol) to patients with burn injuries caused a 43 per cent shortening of the period of treatment. Necrotic eschar separated 7-9 days earlier and the periods necessary to prepare the burn wounds for surgical repair were shortened by 5 days. The success of skin grafting was enhanced with an increased percentage of attachment of the grafts. Necrotic changes of the mucosa of the gastrointestinal tract were found in 35 per cent of patients treated with the drugs as compared with 60 per cent of patients treated by the usual methods.
Iashvili
B P
BP
Baluda
V P
VP
Lukhoyanova
T I
TI
Kozelskaya
L V
LV
Katsitadze
N G
NG
Kamkamidze
M V
MV
Robakidze
T A
TA
D000293:Adolescent; D000328:Adult; D000990:Antithrombin III; D007611:Aprotinin / Q000627:therapeutic use; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use; D010431:Pentoxifylline / Q000627:therapeutic use; D010833:Phytic Acid / Q000627:therapeutic use; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
D005338:Fibrin Fibrinogen Degradation Products; D014810:Vitamin E; D009525:Niacin; D010833:Phytic Acid; D000990:Antithrombin III; D006493:Heparin; D007611:Aprotinin; D010431:Pentoxifylline