[Reactivity to bacterial peptidoglycans in a phagocytosis system. The range of immunological specificity of Escherichia coli peptidoglycan].
The antigenic specificity of E. coli M17 peptidoglycans (PG) was studied in the test system based on the stimulation of neutrophils with PG opsonized with the whole and exhausted IgG fraction of human serum. Within the generic taxon, the PG under study were similar in their antigenic properties. The opsonic activity of IgG exhausted with the preparations of different E. coli strains decreased by 93.2-95.8%. An essential difference of E. coli PG from similar components of other representatives of the family Enterobacteriaceae was observed: in experiments with Serratia marcescens, Klebsiella pneumoniae, Proteus mirabilis, Proteus rettgeri the decrease of opsonic activity was 47.6-79.3%. After the removal of antibodies to PG of remote taxons (Staphylococcus aureus, Micrococcus luteus, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, Branchamella catarrhalis) the decrease of the opsonic effect was less noticeable (9.7-33.8%). The results are discussed from the viewpoint of the immunological peculiarity of PG at different taxonomic levels.
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Azov
D000939:Epitopes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins / Q000276:immunology; D010457:Peptidoglycan / Q000276:immunology*; D010587:Phagocytosis; D013045:Species Specificity
D000939:Epitopes; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D010457:Peptidoglycan
Reaktivnost' k bakterial'nym peptidoglikanam v sisteme fagotsitoza. Diapazon immunologicheskoĭ spetsifichnosti peptidoglikana Escherichia coli.