Responses of mice susceptible or resistant to lethal infection with mouse hepatitis virus, strain JHM, after exposure by a natural route.
CF1 mice were resistant and BALB/cByJ mice were susceptible to the lethal effects of MHV-JHM infection after intranasal inoculation. Virus was recovered rarely from tissues of CF1 mice. In contrast, MHV-JHM was pantropic in BALB/cByJ mice. The peak systemic interferon response of Balb/cByJ mice occurred 30 hours later than that of CF1 mice. Exogenously administered interferon resulted in partial protection of Balb/cByJ mice challenged with MHV-JHM. Prior immunization of susceptible mice with MHV-JHM protected against challenge with homologous or heterologous (MHV-3) virus.
L E
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Garlinghouse
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Smith
D000818:Animals; D006524:Hepatitis, Viral, Animal / Q000276:immunology / Q000382:microbiology*; D007109:Immunity; D007372:Interferons / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains / Q000382:microbiology*; D006517:Murine hepatitis virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D013045:Species Specificity
D007372:Interferons