Treatment-related toxicities with Fluosol-DA 20% infusion during radiation in advanced head and neck malignancies.
Fluosol-DA 20%, a synthetic perfluorocarbon emulsion first developed as a blood substitute, is currently being investigated as a radiation sensitizer. Theoretically, an oxygen-carrying perfluorocarbon emulsion combined with oxygen inhalation might be able to increase tumor response by decreasing the relative proportion of hypoxic tumor cells. Twenty-one patients with advanced head and neck malignancies receiving primary radiation therapy were evaluated for treatment-related toxicity. Mucosal reactions and weight loss during treatment in the group of patients who received the perfluorocarbon emulsion and the group who did not were comparable. Late sequelae appeared comparable. No patient in either group who completed radiation therapy required an interruption of the treatment course. We conclude that Fluosol-DA 20% is a tolerated adjunct to primary radiation therapy. Further study is needed to determine whether the agent will improve local/regional tumor control.
Department of Otolaryngology and Human Communication, Medical College of Wisconsin, Milwaukee 53226.
B H
BH
Campbell
N A
NA
Janjan
R W
RW
Byhardt
R J
RJ
Toohill
D001802:Blood Substitutes; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007262:Infusions, Intravenous; D015337:Multicenter Studies as Topic; D010102:Oxygen Inhalation Therapy; D011832:Radiation Injuries / Q000209:etiology; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage; D011897:Random Allocation; D013280:Stomatitis / Q000209:etiology
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D011838:Radiation-Sensitizing Agents; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination