[An unusual case of a basophilic variant of chronic myelogenous leukemia].
The described basophilic variant of CML in blastic crisis was characterized by a distinct hyperhistaminemia, a moderate hypocoagulation and an insufficiently effective cytostatic therapy. Cell kinetic was characterized by a marked diminution of the whole marketing index (with H3-thymidine) of blasts and immature basophils with simultaneous prolongation of the generation time in comparison to myeloblasts at the chronic stage of the CML. Aneuploid cell clones prevailed in the bone-marrow.
Bondare
D
D
Grasmane
D
D
Baravika
I
I
Petuchov
V
V
Grinberga
L
L
Medne
I
I
Krischtsuna
M
M
Sihle
M
M
D000328:Adult; D001491:Basophils; D001778:Blood Coagulation Disorders / Q000150:complications; D001854:Bone Marrow Cells; D002999:Clone Cells; D004247:DNA / Q000032:analysis; D014644:Genetic Variation; D006636:Histamine Release; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood* / Q000150:complications; D008297:Male; D011003:Ploidies; D013997:Time Factors
D004247:DNA
Ein ungewöhnlicher Fall der basophilen Variante einer chronischen Myelose.