The mechanism of myelopoiesis inhibition in childhood acute leukemia.
The use of leukemic cells as source of CSF has been found to result in sharply reduced colony formation along with diminished proliferative activity of clonogenic precursors of nonleukemic granulo- and monocytopoiesis. Cells of a leukemic clone have no cytotoxic effect on the normal precursors of granulo- and monocytopoiesis and reduce the proliferative potential of these because their proliferation stimulating activity is low.
Vladimirskaya
E B
EB
D000208:Acute Disease; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000473:pathology; D007962:Leukocytes; D014411:Neoplastic Stem Cells / Q000378:metabolism
D003115:Colony-Stimulating Factors