Intracellular immunoglobulin G 'pseudocrystals' in a patient with chronic B-cell leukemia.
A patient with chronic B-cell leukemia in whom the malignant lymphocytes showed intracellular inclusions of immunoglobulin (Ig) G kappa molecules is described. Electron microscopy revealed filamentous material in the nuclear envelopes and in the cisternae of the rough endoplasmic reticulum. These in vivo surface Ig-negative, nonexcreting cells could be stimulated in vitro to excrete immunoglobulin-free light chain molecules into the supernatant, which were not found in the cytoplasm after stimulation.
den Ottolander
G J
GJ
Brederoo
P
P
Schuurman
R K
RK
Teeuwsen
V J
VJ
Schuit
H R
HR
van der Meulen
J
J
Jansen
J
J
Hijmans
W
W
D000368:Aged; D001853:Bone Marrow / Q000276:immunology; D002908:Chronic Disease; D004912:Erythrocytes / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007122:Immunoelectrophoresis; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007938:Leukemia / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D013194:Staining and Labeling
D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains