[Effect of untreated and non-irritating purified coffee and carbonic acid hydroxytryptamides on the gastric mucosa in the rat].
Commercial coffees frequently are processed to reduce the gastric irritation perceived by many coffee consumers. The influence of coffee infusions on gastric mucosa of rats was studied by observing the frequency of distention ulcers. Two kinds of coffee were used: untreated and treated coffee with decreased carbonic acid hydroxytryptamide-content. Infusions of untreated coffee given ad libitum induced severe gastric lesions after a period of at least 13 weeks, while treated coffee did not. In treated coffee the amount of carbonic acid hydroxytryptamides (CHT) is considerably decreased by the so-called CHT-procedure. Further, the ulcerogenic effect of CHT was studied by feeding experiments in rats with the same method resulting in severe lesions of the rat stomach after 3 and 8 weeks, respectively, of feeding. The possible causal effect of the coffee constituent CHT on the ulcerogenic effect of untreated roasted coffee is discussed.
Institut für Pharmakologie und Toxikologie, Philipps-Universität Marburg, Lahnberge.
R
R
Fehlau
K J
KJ
Netter
D000818:Animals; D002254:Carbonates; D002255:Carbonic Acid; D003069:Coffee / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology
D002254:Carbonates; D003069:Coffee; D012701:Serotonin; D002255:Carbonic Acid
Der Einfluss von unbehandeltem und reizarm veredeltem Kaffee und Carbonsäurehydroxytryptamiden auf die Magenschleimhaut der Ratte.