[Pharmacokinetics of albendazole and its metabolites in human body].
High-performance liquid chromatography method was used to determine blood sulfoxide and sulfone, two metabolites of albendazole. Methanol containing 0.4% acetic acid was employed as mobile phase. Wavelength of 290 nm was chosen for uv-detector and mebendazole was used as internal standard. After a single dosage of albendazole 25 mg/kg was taken orally by healthy volunteers and neurocysticercosis patients, sulfoxide and sulfone were found in blood at 20 and 40 min respectively. The blood peak level appeared at 6 h on an average. The metabolites remained as long as 58-72 h in human blood.
Division of Pharmacology, Jilin Agricultural University, Changchun, China.
T Y
TY
Guan
X Y
XY
Gong
W Z
WZ
Sun
S Z
SZ
Liu
L F
LF
Zheng
M G
MG
Li
D000328:Adult; D015766:Albendazole / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003551:Cysticercosis / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D013450:Sulfones / Q000097:blood*; D013454:Sulfoxides / Q000097:blood*
D013450:Sulfones; D013454:Sulfoxides; D015766:Albendazole