Effect of combined ethinyl estradiol and norgestrel oral contraceptives on hepatic functions of albino rats.
The effect of two different doses of ethinyl estradiol and norgestrel combined oral contraceptives (OCs) on hepatic functions of albino rats was studied for a period of six months. Combined OCs treatment caused an increase in glycogen, RNA, total lipids, triglycerides, cholesterol and free fatty acids contents of liver and liver microsomes and decreased the liver weight/body weight ratio and phospholipid contents. Liver aminotransferase activities were elevated in the OCs treated animals whereas alkaline phosphatase activity remained unchanged. The biochemical changes were found to be dose dependent. Thus the present study has shown that the combined OCs treatment for six months is associated with altered hepatic functions. The possible mechanism of such an alteration of hepatic functions on OCs treatment is discussed.
Mandal
B
B
Dey
C D
CD
Maity
C R
CR
D000818:Animals; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D004247:DNA / Q000032:analysis; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008112:Liver Glycogen / Q000032:analysis; D009644:Norgestrel / Q000008:administration & dosage*; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats
D003277:Contraceptives, Oral, Combined; D008055:Lipids; D008112:Liver Glycogen; D011506:Proteins; D009644:Norgestrel; D004997:Ethinyl Estradiol; D012313:RNA; D004247:DNA