Antilupus activity of copper (II).
Collagen-like syndrome was induced in rats by oral hydralazine administration during 5 months. After 4 months, a subgroup of rats was shifted from the standard diet to the diet supplemented with copper (II) (60 micrograms of copper per g of pellet) as copper sulphate. A decreased serum copper concentration was noted, LE cells were observed in the blood of 75% of rats fed with standard diet. In the subgroup of copper supplemented rats, the LE cells were observed in 40% of rats only. The activity of superoxide dismutase, the antioxidative copper-dependent enzyme, was significantly lower in erythrocytes of rats fed with standard diet, than the activity in rats fed with copper supplemented diet. These results are briefly discussed.
A
A
Jendryczko
M
M
Drozdz
K
K
Magner
D000818:Animals; D003095:Collagen Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D003300:Copper / Q000097:blood / Q000494:pharmacology*; D005609:Free Radicals; D006830:Hydralazine; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009504:Neutrophils; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000097:blood
D005609:Free Radicals; D006830:Hydralazine; D003300:Copper; D013482:Superoxide Dismutase