[The rate of outflow of penetrating cations does not depend on the energy state of mitochondria].
Inhibiton of respiration at 0 degrees C believed to decrease the membrane potential in mitochondria did not lead to a substantial acceleration of the efflux of penetrating cations (triphenylmethylphosphonium, Cs- valinomycin). On the contrary the energy-dependent influx of the cations was rapidly inhibited indicating that there was no prolonged delay in the membrane deenergization. Low sensitivity of the cation efflux to respiration inhibition suggests under the conditions studied the metabolic component of the membrane potential to be rather small.
Skul'skiĭ
I A
IA
Glazunov
V V
VV
Savina
M V
MV
D000818:Animals; D002412:Cations / Q000378:metabolism*; D002586:Cesium / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D014634:Valinomycin / Q000494:pharmacology
D002412:Cations; D007473:Ion Channels; D002586:Cesium; D014634:Valinomycin
Skorost' vykhoda pronikaiushchikh kationov ne zavisit ot énergeticheskogo sostoianiia mitokhondriĭ.