Aggristin (ristomycin) precipitation test: a new tool for the detection of fibrin monomer and fibrin degradation products.
The specific detection of fibrin monomer and fibrin degradation products is of high importance in the laboratory diagnosis of intravascular clotting (disseminated intravascular coagulation, deep vein thrombosis). The methods proposed until now are partly time-consuming, needing special laboratories or insensitive and poorly specific. Applying ristomycin instead of ristocetin (another member of the vancomycin antibiotics) a new simple, specific and sensitive method has been elaborated and recommended for the laboratory diagnosis of intravascular coagulation and its differentiation from primary fibrinogenolysis. The results obtained from in vitro and animal experiments and from human studies are presented.
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Pfliegler
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Vogel
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Boda
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Zajka
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Rak
D000818:Animals; D011232:Chemical Precipitation; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis*; D005260:Female; D005337:Fibrin / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D012310:Ristocetin; D013300:Streptokinase / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D013924:Thrombophlebitis / Q000175:diagnosis
D005338:Fibrin Fibrinogen Degradation Products; D012310:Ristocetin; D005337:Fibrin; D013300:Streptokinase; D013917:Thrombin