Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia.
Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and 14q11. 8q24 is known to encode the oncogene c-myc, while 14q11 encodes the genes for T-cell receptor-alpha (TCR-alpha) and T-cell receptor-delta (TCR-delta). Therefore, this chromosomal translocation t(8;14) (q24;q11) seemed to be unique and specific to T-cell malignancy.
Inaba
T
T
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Murakami
S
S
Oku
N
N
Itoh
K
K
Ura
Y
Y
Nakanishi
S
S
Shimazaki
C
C
Nishio
A
A
Nakagawa
M
M
Fujita
N
N
D000328:Adult; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D015342:DNA Probes; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic
D015342:DNA Probes; D005819:Genetic Markers; D011948:Receptors, Antigen, T-Cell