Prevention of experimental immune complex glomerulonephritis by specific inactivation of immunoreactive cells.
In a previous experiment we were able to induce in rabbits a state of specific tolerance against bovine serum albumin (BSA) by pretreatment with highly hot labelled BSA-125 I thus preventing immune complex glomerulonephritis. Despite successful suppression of antibody production, the question remained to be answered if this was due to an nonspecific effect of immunosuppression by radio-iodinated BSA or caused by the elimination of the corresponding lymphocyte clone according to the clonal deletion theory. Therefore, rabbits, rendered tolerant BSA antigen were treated with another antigen, bovine gamma globulin (BCG) and developed classical immune complex glomerulonephritis and vice versa. These results strongly suggest a specific elimination of the effector cell clones only, the exact mechanism of which still remains to be elucidated.
Dienes
H P
HP
Filipp
G
G
Thoenes
W
W
Biro
G
G
Schumacher
H
H
Kiesmann
W
W
Lehmann
G
G
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D002417:Cattle; D000939:Epitopes; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D007105:Immune Complex Diseases / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D007108:Immune Tolerance; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000473:pathology; D008212:Lymphocyte Depletion; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology*; D005719:gamma-Globulins / Q000008:administration & dosage / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D000939:Epitopes; D007457:Iodine Radioisotopes; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine