Age and strain differences in some behavioral effects of intracranial substance P.
Intracerebroventricular (ICV) injections of substance P (SP) induce a vigorous reciprocal hindlimb scratching (RHS) syndrome, accompanied by extensive grooming behavior. There is a significant (approximately 1000X) difference in responsiveness to SP, as measured by RHS and grooming, in mice as a function of genetic strain (Swiss/Webster, C57 or DBA) and age. There was considerable specificity in the ability of drugs to increase responsiveness in the least responsive type of mouse (aged DBA/2J). Responding in old DBAs was enhanced by high doses of naloxone, suggesting the involvement of opioid peptides. Significant enhancement of responding by alpha-methyl tyrosine and propranolol, but not by phenoxybenzamine or haloperidol, indicated that beta-adrenergic systems are also involved. Similar manipulations of serotonergic systems were without effect.
M E
ME
Hall
P A
PA
Grantham
J M
JM
Stewart
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology; D013045:Species Specificity; D013373:Substance P / Q000494:pharmacology*; D019805:alpha-Methyltyrosine; D010133:p-Chloroamphetamine / Q000494:pharmacology
D008781:Methyltyrosines; D013373:Substance P; D009270:Naloxone; D010133:p-Chloroamphetamine; D019805:alpha-Methyltyrosine; D010134:Fenclonine; D003913:Dextroamphetamine