[Effect of testosterone on nucleic acid synthesis in spermatogenic epithelial cells of irradiated animals].
A study was made of changes in nucleic acid synthesis in proliferating germ cell populations of animals irradiated with doses of 2 and 4 Gy. The administration of exogenous testosterone was shown to stimulate DNA synthesis, inhibited by the effect of radiation, in spermatogonium populations of A1-4, intermediate, and B types, and in preleptotene primary spermatocytes; RNA synthesis was increased in the same populations of spermatogonia and pachytene primary spermatocytes. The obtained results indicate that exogenous testosterone exerts a beneficial effect on spermatogenesis damaged by ionizing radiation.
L F
LF
Ganzenko
V G
VG
Kondratenko
D000818:Animals; D003037:Cobalt Radioisotopes; D004247:DNA / Q000096:biosynthesis*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D012313:RNA / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D013739:Testosterone / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D013739:Testosterone; D012313:RNA; D004247:DNA
Deĭstvie testosterona na sintez nukleinovykh kislot v kletkakh spermatogennogo épiteliia obluchennykh zhivotnykh.