Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms.
Histologic findings in mice with severe combined immunodeficiency (SCID) were remarkably uniform, consisting of lymphopenia, a rudimentary thymic medulla without cortex, relatively empty splenic follicles and lymph nodes, and undeveloped bronchial and gastrointestinal lymphocytic foci. Fluorescence-activated cell sorter studies revealed a few T cells (apparently nonfunctional) in thymus and spleen; interestingly, these cells seemed highly disposed to neoplasia, because thymic T-cell lymphomas were observed in 41 of 269 mice. No pre-B or B cells could be identified. Cells of the myeloid lineage appeared normal. Reconstitution of lymphoid tissues was achieved after intravenous injection of histocompatible bone marrow cells.
Custer
R P
RP
Bosma
G C
GC
Bosma
M J
MJ
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000473:pathology; D001772:Blood Cell Count; D016026:Bone Marrow Transplantation; D002469:Cell Separation; D004195:Disease Models, Animal; D005434:Flow Cytometry; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000235:genetics / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D009362:Neoplasm Metastasis; D013154:Spleen / Q000473:pathology; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D013953:Thymus Neoplasms / Q000473:pathology
D000911:Antibodies, Monoclonal