Differential sensitivity of [3H]nitrendipine binding to cations of toxicological interest in various rat brain areas.
[3H]Nitrendipine ([3H]NTP) is a radiolabelled calcium antagonist which can be used to study neuronal calcium (Ca2+) channels. The interaction of Mn2+, Zn2+, Pb2+ and La3+ on [3H]NTP binding was studied in 3 brain areas particularly rich in [3H]NTP binding sites. Differences were observed in the brain regional distribution of [3H]NTP binding as well as in their sensitivity to the metal ions Pb, Mn and Zn. The binding data suggest that neuronal Ca2+ channels in different brain areas display distinct sensitivity to selected divalent cations.
Rius
R A
RA
Govoni
S
S
Battaini
F
F
Trabucchi
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D008670:Metals / Q000633:toxicity*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000378:metabolism; D009568:Nitrendipine; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D002121:Calcium Channel Blockers; D007473:Ion Channels; D008670:Metals; D014316:Tritium; D009568:Nitrendipine; D009543:Nifedipine