6-(substituted methylene)penems, potent broad spectrum inhibitors of bacterial beta-lactamase. II. Racemic furyl and thienyl derivatives.
A series of racemic 6-(substituted methylene)penems have been prepared. These compounds contain a 5-membered monoheteroaromatic ring at C-8. The antibacterial/synergistic and beta-lactamase inhibitory activities of both E- and Z-isomers and 2-substituted derivatives are compared.
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
N J
NJ
Broom
K
K
Coleman
P A
PA
Hunter
N F
NF
Osborne
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D004357:Drug Synergism; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D018398:Homeodomain Proteins; D007711:Klebsiella pneumoniae / Q000187:drug effects; D015394:Molecular Structure; D015513:Oncogene Proteins; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D018398:Homeodomain Proteins; D015513:Oncogene Proteins; C489494:TLX3 protein, human; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams