[Status of plasmapheresis and cyclosporin A in the treatment of systemic lupus erythematosus].
We report the history of 2 teenagers suffering from systemic lupus erythematosus for more than 5 years. Both of them were treated with total plasma exchange (TPE) and Ciclosporin A. They responded well to this therapy and achieved remissions. Especially the 2nd patient showed a dramatic clinical improvement after a relapse caused by sun exposure. Both treatment modalities are discussed and the following conclusions are drawn: TPE is an important therapeutic element in treating patients with SLE, whereas Ciclosporin A is not recommended for therapy of first choice. Further prospective and controlled studies have to show, if there is a benefit of this therapy, especially in childhood.
Graf
N
N
Klinik für Kinder- und Jugendmedizin, Homburg/Saar.
Bambauer
R
R
Jost
W
W
Schäfer
M
M
D000293:Adolescent; D002648:Child; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*; D008181:Lupus Nephritis / Q000628:therapy; D010956:Plasmapheresis / Q000295:instrumentation*; D012008:Recurrence
D003524:Cyclosporins
Der Stellenwert der Plasmapherese und des Cyclosporin A in der Behandlung des systemischen Lupus erythematodes.