The haemostatic effects of hydroxyethyl starch (HES) used as a volume expander.
Hydroxyethyl starch (HES 450.000/0.7; Hespan 6.0 g/100 ml) was compared with standard crystalloid solutions in postoperative volume replacement in 20 patients undergoing routine orthopaedic surgery. The HES group showed no clinical evidence of haemorrhage and no laboratory evidence of significant haemostatic defects as assessed by standard coagulation tests, platelet aggregation and fibrinogen concentrations. There was a slight shortening in the thrombin time and a smaller increase in post-operative FVIII RAg and FVIII RCof levels in the HES group. HES is a safe and effective volume expander for postoperative use.
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Macintyre
I J
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Mackie
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Ho
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Tinker
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Bullen
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Machin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D001780:Blood Coagulation Tests; D001803:Blood Transfusion; D002648:Child; D000077324:Crystalloid Solutions; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007552:Isotonic Solutions; D008875:Middle Aged; D010952:Plasma Substitutes / Q000627:therapeutic use*; D010974:Platelet Aggregation; D011182:Postoperative Care; D013213:Starch / Q000031:analogs & derivatives*; D014841:von Willebrand Factor / Q000032:analysis
D000941:Antigens; D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D014841:von Willebrand Factor; D005169:Factor VIII; D005340:Fibrinogen; D013213:Starch