Hypokinetic-rigid extrapyramidal side effects of neuroleptics: the relationship of the silent period in EMG and HVA and 5-HIAA in CSF.
The relationship between cerebrospinal fluid levels of HVA and 5-HIAA and the hypokinetic-rigid symptoms that occurred during oral administration of haloperidol in twenty schizophrenic patients was investigated. Measurement of the silent period in the EMG was used for evaluation of these symptoms. The results support the hypothesis of a positive correlation between the CSF HVA and the hypokinetic-rigid side effect and a negative correlation between the pretherapeutic dopamine turnover and the risk of neuroleptic Parkinsonism.
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D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000503:physiopathology; D004558:Electric Stimulation; D004576:Electromyography; D006220:Haloperidol / Q000009:adverse effects; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D009132:Muscles / Q000503:physiopathology
D014150:Antipsychotic Agents; D006897:Hydroxyindoleacetic Acid; D006220:Haloperidol; D006719:Homovanillic Acid