Reduction potentials of imine-substituted, biologically active pyridines: possible relation to activity.
Cyclic voltammetry data were obtained for a number of biologically active compounds which incorporate imine substitution on the pyridine nucleus. The reductions in acid (iminium ion formation) were for the most part reversible, and in the range of -0.5 to -0.7V. The toxic effect of these drugs is thought to be caused by the generation of reactive oxygen radicals that arise via charge transfer, or by disruption of electron transport chains.
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
P
P
Kovacic
M A
MA
Kassel
A
A
Castonguay
W R
WR
Kem
B A
BA
Feinberg
D055598:Chemical Phenomena; D002621:Chemistry; D004563:Electrochemistry; D004579:Electron Transport; D007097:Imines; D010084:Oxidation-Reduction; D011725:Pyridines
D007097:Imines; D011725:Pyridines