Dextran sulfate-induced peritoneal lysophospholipase activity varies among mouse strains.
Lysophospholipase (LPL) activity resulting from the intraperitoneal injection of dextran sulfate (DS) was studied in different mouse strains. AKR/J and BALB/cByJ mouse strains showed decreased LPL levels when a low molecular weight DS was injected but increased LPL activity when high molecular weight DS was injected intraperitoneally. C57BL/6 mice had increased LPL activity with low molecular weight DS but decreased LPL activity with high molecular weight DS. All three mouse strains showed increased peritoneal-cell changes when injected with DS of a molecular weight of 79,000.
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D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D004790:Enzyme Induction; D005260:Female; D008245:Lysophospholipase / Q000096:biosynthesis* / Q000378:metabolism; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics; D008807:Mice, Inbred BALB C / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D010740:Phospholipases / Q000096:biosynthesis*; D013045:Species Specificity
D003911:Dextrans; D016264:Dextran Sulfate; D010740:Phospholipases; D008245:Lysophospholipase