Selected immunologic properties of tiprinast, a non-steroidal antiallergy agent.
Tiprinast [(3,4-dihydro-5-methyl-6-(2-methylpropyl)-4-oxothieno[2,3-d]- pyrimidine-2-carboxylic acid] is a new antiallergy compound which shares many of the pharmacological actions of disodium cromoglycate (DSCG). Both compounds inhibit passive cutaneous anaphylaxis in the rat, histamine release from rat peritoneal mast cells and nasal constriction due to antigen in the rat. In all cases tiprinast is more potent than DSCG and also longer acting.
E
E
Gillespie
K W
KW
Dungan
A W
AW
Gomoll
R J
RJ
Seidehamel
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001507:Beclomethasone / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006634:Histamine H1 Antagonists; D011743:Pyrimidines; D001507:Beclomethasone; D004205:Cromolyn Sodium; C046856:tiprinast