[Occurrence of subdural hematoma closely associated with danazol administration in a patient with refractory ITP].
We reported a 34-year-old female patient with refractory idiopathic thrombocytopenic purpura (ITP) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level. It is strongly suggested that danazol should be very carefully administered in ITP patients with serious bleeding tendency.
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima, Japan.
K
K
Shinmyozu
T
T
Okadome
Y
Y
Maruyama
I
I
Maruyama
M
M
Osame
M
M
Tara
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D003613:Danazol / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006408:Hematoma, Subdural / Q000139:chemically induced*; D006801:Humans; D011245:Pregnadienes / Q000009:adverse effects*; D011486:Protein C / Q000032:analysis; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000188:drug therapy*
D011245:Pregnadienes; D011486:Protein C; D000990:Antithrombin III; D005340:Fibrinogen; D003613:Danazol