Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women.
Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.
A V
AV
Muchmore
J M
JM
Decker
D001402:B-Lymphocytes / Q000187:drug effects; D002845:Chromatography / Q000379:methods; D003101:Collodion; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000652:urine*; D066298:In Vitro Techniques; D007525:Isoelectric Focusing; D008213:Lymphocyte Activation / Q000187:drug effects; D008970:Molecular Weight; D009088:Mucoproteins; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000302:isolation & purification / Q000494:pharmacology / Q000652:urine*; D013601:T-Lymphocytes / Q000187:drug effects; D058949:Uromodulin
D000939:Epitopes; D007166:Immunosuppressive Agents; D009088:Mucoproteins; D011257:Pregnancy Proteins; C548612:UMOD protein, human; D058949:Uromodulin; D003101:Collodion