Comparison of in vivo and in vitro methods for assessing effects of allyl alcohol on the liver.
Allyl alcohol was administered intraperitoneally (i.p.) to female Fischer 344 rats at doses of 0, 3, 10 and 30 mg/kg daily for 7 days. Plasma sorbitol dehydrogenase was minimally elevated. No dose-related changes were observed in hexobarbital oxidation, aniline hydroxylation, or ethylmorphine demethylation. Aldrin epoxidation was slightly elevated. Naphthol glucuronidation and glutathione-S-transferase activity with 1,2-dichloro-4-nitrobenzene were increased. Results from in vivo studies on the metabolism of lindane were in close agreement with the in vitro measurements suggesting that daily treatment for one week with allyl alcohol at doses of 3, 10 and 30 mg/kg has no significant effect on phase I pathways, has a selective effect on phase II pathways and, under the conditions of this experiment, has minimal hepatotoxic effects in these rats.
Trela
B A
BA
Carlson
G P
GP
Chadwick
R W
RW
Copeland
M F
MF
D000433:1-Propanol / Q000633:toxicity; D000818:Animals; D002250:Carbon Radioisotopes; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D001556:Hexachlorocyclohexane / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000032:analysis; D020005:Propanols; D051381:Rats; D011916:Rats, Inbred F344
D002250:Carbon Radioisotopes; D020005:Propanols; C006463:allyl alcohol; D001556:Hexachlorocyclohexane; D000433:1-Propanol; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase