Characterization of a human granulocyte differentiation antigen (CDw15) commonly recognized by monoclonal antibodies.
Many different anti-human granulocyte monoclonal antibodies recognize the same carbohydrate antigen which contains the trisaccharide 3-fucosyl-N-acetyllactosamine. The antigen is expressed mainly on two cell surface glycoproteins of molecular weights around 105 K and 160 K which are apparently not members of the LFA-1 family of proteins. Although specific for granulocytes in blood, the antigen is expressed on a wide range of non-haemopoietic cell types.
N C
NC
McCarthy
M T
MT
Albrechtsen
M A
MA
Kerr
D000818:Animals; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000943:Antigens, Differentiation; D000954:Antigens, Surface / Q000032:analysis; D000939:Epitopes / Q000032:analysis; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D016256:Lewis X Antigen / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008970:Molecular Weight; D009504:Neutrophils / Q000276:immunology*; D011863:Radioimmunoassay; D013347:Subcellular Fractions / Q000276:immunology
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D000939:Epitopes; D016256:Lewis X Antigen; C046168:neutrophil differentiation antigens