Effect of calcitonin on gastric emptying and on serum insulin and gastrin concentrations after ingestion of a mixed solid-liquid meal in humans.
In a double-blind placebo-controlled study, we examined the effect of calcitonin on gastric emptying, and on serum concentrations of gastrin, insulin, glucose, calcium, and phosphorus after a mixed solid-liquid meal in 11 healthy men. Synthetic salmon calcitonin was administered as a 415 pmol i.v. bolus injection followed by a 90-min infusion to reach an overall dose of 62.25 pmol/kg body mass. Gastric emptying of a radiolabeled meal was surveyed by means of a gamma camera. A pronounced inhibition of gastric emptying with calcitonin was observed in all subjects (median gastric half emptying time 60.3 min after placebo versus 197.6 min after calcitonin; p less than 0.001). Calcitonin did not effect the postprandial gastrin release, nor did it change significantly the serum calcium or phosphorus concentrations. A decreased postprandial insulin release by calcitonin (mean +/- SEM area under the insulin curve 2,124.6 +/- 382.0 min mU L-1 after placebo versus 640.9 +/- 124.0 min mU L-1 after calcitonin; p less than 0.002) was accompanied by a different pattern of serum glucose concentrations during the infusion of the hormone when compared to the situation with a placebo. We discuss potential mechanisms and clinical relevance of our findings.
Department of Gastroenterology, Silesian School of Medicine, Katowice, Poland.
K
K
Jonderko
G
G
Jonderko
T
T
Gołab
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D004064:Digestive System / Q000000981:diagnostic imaging; D004311:Double-Blind Method; D004435:Eating; D005746:Gastric Emptying / Q000187:drug effects*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010758:Phosphorus / Q000097:blood; D011877:Radionuclide Imaging
D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D010758:Phosphorus; C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium