Antihypertensive properties of ketanserin in combination with beta-adrenergic blocking agents.
The antihypertensive effect of ketanserin in combination with beta-adrenergic blockade was assessed in a double-blind crossover (4 weeks) manner in 10 patients with essential hypertension. The addition of ketanserin (40 mg b.i.d.) to optimal doses of beta-adrenergic blockers had significant antihypertensive effects compared with treatment with beta-adrenergic blockers alone. When followed for 24 h at steady-state conditions, ketanserin effectively reduced the blood pressure during a major part of the day, with maximal effect occurring at the time of the peak plasma concentration of ketanserin (1-2 h after tablet intake). Six patients initially reported a slight sedation during ketanserin treatment.
Hedner
T
T
Persson
B
B
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007650:Ketanserin; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D010880:Piperidines; D012702:Serotonin Antagonists; D007650:Ketanserin