Effects of histamine and a histamine releaser on body temperature and blood levels of metabolites and thyroid hormones in the pigeon.
Intravenous injections of histamine (20-600 micrograms) as well as of compound 48/80 (10-100 micrograms), a histamine releaser, produced a significant drop in the cloacal temperature of pigeons when examined during the initial 2 hr period following the injections. The effect of histamine was dose-dependent. A trend towards a drop in foot temperature was indicated with higher doses of histamine, but no effect was seen with compound 48/80. Plasma free fatty acid (FFA) levels were significantly increased at 15 and 30 min post-injection of histamine but an increase with compound 48/80 was obtained only at 15 min. While histamine produced a hyperglycaemic effect that was significant only at 30 min post-injection, compound 48/80 showed no such effect. Histamine caused a significant drop in the plasma levels of thyroxine (T4) and triiodothyronine (T3) both at 15 and 30 min post-injection. A similar trend in the thyroid hormone levels was also produced by compound 48/80, except for the T4 level at 15 min post-injection which showed no change.
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects*; D002988:Cloaca / Q000187:drug effects; D010856:Columbidae / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006632:Histamine / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D013963:Thyroid Hormones; D014284:Triiodothyronine; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D013974:Thyroxine