Effects of anti-inflammatory drugs on rat paw oedema and leukocyte migration.
High doses of cyclooxygenase inhibitors (e.g. indomethacin) reduce the leukocyte accumulation in the carrageenin soaked sponges. They are, however, inactive in bradykinin-induced oedema and in the reversed passive Arthus reaction (RPA). A potent cyclooxygenase and lipoxygenase inhibitor, BW 755C, was equally active in the bradykinin-induced oedema, leukocyte migration and in the RPA. Consequently these methods may help to differentiate anti-inflammatory drugs which act via cyclooxygenase or lipoxygenase pathways in vivo.
Engler
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Szelenyi
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001183:Arthus Reaction / Q000503:physiopathology; D001920:Bradykinin; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors; D003911:Dextrans; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D005534:Foot Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects* / Q000473:pathology; D016859:Lipoxygenase Inhibitors; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D003911:Dextrans; D016859:Lipoxygenase Inhibitors; D002351:Carrageenan; D001920:Bradykinin