[Toxicological considerations in the evaluation of veterinary drugs].
Interactions between veterinary pharmacotherapy, toxicology of residues, prevention of residues of veterinary drugs and the evaluation of veterinary drug files are discussed on the basis of a number of examples. Sulphadimidine is used to treat atrophic rhinitis in medicated feeds which do not benefit the animal but are the cause of persistent sulphonamide residues in feed mills and husbandry. Carbadox is a potentially effective prophylactic feed additive for the prevention of swine dysentery, but is mostly used in high dosages which are almost toxic for the animals, and used during unnecessary prolonged periods. It is also prescribed as a therapeutic agent in which case a symptom of poisoning, dry faeces, is mistaken for a sign of recovery. Carbadox and/or its metabolites are carcinogenic and its use should be restricted to a bare minimum. Furazolidone is an example of an effective veterinary drug, the use of which should be limited by the fact that detoxification mechanisms of the animals, may result in the appearance of reactive metabolites which are available in the gastro-intestinal tract of the consumer. The central issue in a 'minimal residue' policy regarding the use of veterinary drugs should be the selection of effective drugs. Such a selection could result in a significant reduction of the incidence of veterinary drug residues. Second to this issue is the question of the extent to which residue toxicology should modulate the use of veterinary drugs.
Centraal Diergeneeskundig Instituut, Farmacologisch Laboratorium, Lelystad.
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Vroomen
D000818:Animals; D002218:Carbadox / Q000633:toxicity; D004350:Drug Residues / Q000506:poisoning*; D004358:Drug Therapy / Q000662:veterinary*; D064420:Drug-Related Side Effects and Adverse Reactions; D005503:Food Additives / Q000506:poisoning*; D005664:Furazolidone / Q000633:toxicity; D006801:Humans; D012222:Rhinitis, Atrophic / Q000517:prevention & control / Q000662:veterinary; D013418:Sulfamethazine / Q000008:administration & dosage / Q000009:adverse effects; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control
D005503:Food Additives; D013418:Sulfamethazine; D005664:Furazolidone; D002218:Carbadox
Toxicologische overwegingen bij de beoordeling van diergeneesmiddelen.