Trisomy 13 and myelodysplastic syndrome.
The clinical and cytogenetic data of a patient with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB) and trisomy 13 as the sole abnormality are presented. This appears to be only the second report of such a patient. The presence of trisomy 13 is confirmed by in situ hybridization using an alphoid repeat probe L1.26, which is specific for the centromeres of both chromosomes 13 and 21.
Department of Human Genetics, State University Hospital, Leiden, The Netherlands.
G C
GC
Beverstock
J E
JE
Ploem
H
H
Wessels
D
D
van de Keur
P
P
Mollevanger
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014314:Trisomy