Effects of dexamethasone on human natural killer cell cytotoxicity, interferon production, and interleukin-2 receptor expression induced by microbial antigens.
Dexamethasone inhibits the expression of the interleukin-2 receptor, the synthesis of immune interferon, and the development of natural killer cells when added to peripheral blood mononuclear cells cultured with soluble microbial antigens (purified protein derivative and a polysaccharide extract from Candida albicans [MPPS]) or human recombinant interleukin-2.
Piccolella
E
E
Lombardi
G
G
Vismara
D
D
Del Gallo
F
F
Colizzi
V
V
Dolei
A
A
Dianzani
F
F
D000942:Antigens, Bacterial / Q000276:immunology*; D000946:Antigens, Fungal / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000187:drug effects*; D011971:Receptors, Immunologic / Q000096:biosynthesis*; D015375:Receptors, Interleukin-2; D014373:Tuberculin / Q000276:immunology
D000942:Antigens, Bacterial; D000946:Antigens, Fungal; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D014373:Tuberculin; D003907:Dexamethasone; D007372:Interferons