Cutaneous tissue repair: basic biologic considerations. I.
Wound repair of the integument is reviewed in the context of new developments in cell biology and biochemistry. Injury of the skin and concomitant blood vessel disruption lead to extravasation of blood constituents, followed by platelet aggregation and blood clotting. These events initiate inflammation and set the stage for repair processes. The macrophage plays a pivotal role in the transition between wound inflammation and repair (granulation tissue formation), since this cell both scavenges tissue debris and releases a plethora of biologically active substances that include growth factors. Although concrete evidence is lacking, growth factors are probably at least partially responsible for the angiogenesis and fibroplasia (granulation tissue) that gradually fill the wound void. If the epidermal barrier is disrupted during injury, reepithelialization begins within 24 hours and proceeds first over the margin of residual dermis and subsequently over granulation tissue. The signals for angiogenesis, fibroplasia, neomatrix formation, and reepithelialization in wound repair are not known, but a number of possibilities are discussed. Matrix remodeling is the last stage of wound repair and gradually increases the scar tensile strength to 70% to 80% of normal skin.
Clark
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D000818:Animals; D001777:Blood Coagulation; D003094:Collagen / Q000032:analysis; D004848:Epithelium / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000473:pathology; D005353:Fibronectins / Q000032:analysis; D006097:Granulation Tissue / Q000502:physiology; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D007249:Inflammation / Q000473:pathology; D009389:Neovascularization, Pathologic; D009504:Neutrophils / Q000473:pathology; D011509:Proteoglycans / Q000032:analysis; D012867:Skin / Q000293:injuries; D012879:Skin Physiological Phenomena; D014945:Wound Healing
D005353:Fibronectins; D011509:Proteoglycans; D006820:Hyaluronic Acid; D003094:Collagen