Innervation of synovial membrane and meniscus.
Substance P-immunofluorescent nerves, which are closely connected to pain transmission, were shown in human knee synovial membrane and menisci. Both tissues also contained enkephalin-immunofluorescent nerves, which are probably involved in the modulation of pain transmission. Previous suggestions on the presence of nociceptive receptors in these non-cartilaginous joint structures, made on a histological basis, are thus confirmed by a specific immunohistochemical method.
Grönblad
M
M
Korkala
O
O
Liesi
P
P
Karaharju
E
E
D004745:Enkephalins / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006621:Hip Joint; D006801:Humans; D007719:Knee Joint; D008592:Menisci, Tibial / Q000032:analysis / Q000294:innervation*; D011984:Sensory Receptor Cells / Q000032:analysis; D013194:Staining and Labeling; D013373:Substance P / Q000032:analysis; D013583:Synovial Membrane / Q000032:analysis / Q000294:innervation*; D014953:Wrist
D004745:Enkephalins; D013373:Substance P