Action of organic antagonists on neuronal calcium currents.
The low-voltage activated, fast inactivating calcium (Ca) conductance recently found in dorsal root ganglion cells is largely inert to the Ca agonist and antagonists (BAY K 8644, nifedipine and verapamil). The ubiquitous, slowly inactivating Ca conductance is strongly depressed by verapamil (20 to 100 X 10(-6) M) and with [Ca]o greater than or equal to 2 mM also by BAY K 8644, while nifedipine was weakly agonistic or ineffective in a comparable range of drug concentrations (10(-9) to 5 X 10(-7 M). The difference in affinity to verapamil renders possible a pharmacological separation of the two channels.
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D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000818:Animals; D001717:Birds; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D004594:Electrophysiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007473:Ion Channels; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium