[The membrane theory of primary arterial hypertension (development of the concept of the nature of hypertension)].
The author reviews the data from the recent researches developing the idea which consider primary hypertension as a consequence of wide-spread cell membrane alteration (the membrane conception of primary hypertension). The main recent advances, in favour of this point of view, are the following: demonstration of alteration in the calmodulin-membrane Ca pump interaction in erythrocytes and platelets in human essential hypertension as well as in spontaneous hypertension in rats; registration of lowered plasma membrane electric potential in different types of cells; demonstration of an increased concentration of ionized cytoplasmic calcium in different types of cells. Formation of increased concentrations of free calcium in cell cytoplasm is considered to be the principal pathogenic factor of primary hypertension. Chronic neuropsychic overstrain accelerates the development of hypertension, thus promoting the development of insufficient membrane regulation of cytoplasmic free calcium concentration. At this aspect the membrane conception coincides with the neurogenic theory of essential hypertension by G. Lang.
Postnov
Iu V
IuV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D051381:Rats
D002147:Calmodulin; D007473:Ion Channels; D002118:Calcium
O membrannoĭ kontseptsii pervichnoĭ arterial'noĭ gipertenzii (k razvitiiu predstavleniĭ o prirode gipertonicheskoĭ bolezni).