[A case of thymoma with an increased sensitivity to pancuronium].
It is well-known that anesthesia and surgery may precipitate muscle weakness in the patients with myasthenia gravis and some patient were not recognized as myasthenia until such episodes. A 74-year-old woman with increased sensitivity to pancuronium who, in spite of the very high titer of anti-acetylcholine receptor antibodies, showed no clinical manifestation of myasthenia gravis before operation. And computed tomographies revealed the presence of a thymoma in her anterior mediastinum. Although we have performed extended thymectomy, ptosis appeared 4 month after the operation. This patient might be called as "premyasthenic state" or "subclinical MG".
Hirai
T
T
Department of Surgery, Utano National Hospital, Kyoto, Japan.
Ito
M
M
Abe
R
R
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D009123:Muscle Hypotonia / Q000139:chemically induced; D009157:Myasthenia Gravis / Q000150:complications / Q000276:immunology; D010197:Pancuronium / Q000009:adverse effects*; D011950:Receptors, Cholinergic / Q000276:immunology; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D010197:Pancuronium