Crystal structure of a left-handed RNA tetramer, r(C-br8G)2.
The crystal structure of the modified RNA tetramer, r(C-br8G-C-br8G), was determined by x-ray methods. The crystals are trigonal and belong to the space group P3212. There are three independent tetramers in the unit cell and each forms a left-handed duplex similar to Z-DNA regarding the orientations of the base moiety and the sugar puckerings in guanosine and cytidine. The effect of the additional bromine atom and 2'-hydroxy group on the stabilization of the Z-form structure are also described.
Nakamura
Y
Y
Fujii
S
S
Urata
H
H
Uesugi
S
S
Ikehara
M
M
Tomita
K
K
D003460:Crystallization; D003597:Cytosine Nucleotides; D006151:Guanosine / Q000031:analogs & derivatives; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides; D012313:RNA; D014961:X-Ray Diffraction
D003597:Cytosine Nucleotides; D009843:Oligoribonucleotides; D006151:Guanosine; C035169:8-bromoguanosine; D012313:RNA