Clinical course of spontaneous reactivation of hepatitis B virus infection in patients with chronic hepatitis B.
The purposes of this study were (a) to describe the clinical and biochemical manifestations associated with spontaneous reactivation of hepatitis B virus as defined by the reappearance of hepatitis B virus DNA in serum using dot-blot hybridization and (b) to determine whether the clinical and biochemical manifestations associated with hepatitis B virus reactivation were different in patients with and without human immunodeficiency virus-1 infection. During 1 yr, 110 French patients were admitted to Hôpital Beaujon for chronic hepatitis B. Fourteen were found to have hepatitis B virus reactivation; of these, three were anti-human immunodeficiency virus-1-positive. These 14 patients were HBsAg-positive for 60 mo (range = 6 to 180 mo). Clinical manifestations related to reappearance of hepatitis B virus DNA were present in 11 patients. HBeAg/anti-HBe status did not change in nine patients in whom hepatitis B virus reactivation would not have been recognized without hepatitis B virus DNA testing. Cirrhosis was present in nine patients. Four patients, of whom two were anti-human immunodeficiency virus-1-positive, had fulminant liver failure. Two patients died; one was anti-human immunodeficiency virus-1-positive. One patient was given an emergency transplant.
Levy
P
P
Service d'Hépatologie, INSERM U-24, Clichy, France.
Marcellin
P
P
Martinot-Peignoux
M
M
Degott
C
C
Nataf
J
J
Benhamou
J P
JP
D000328:Adult; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications; D015497:HIV-1; D006509:Hepatitis B / Q000097:blood* / Q000150:complications; D006510:Hepatitis B Antibodies / Q000097:blood; D006511:Hepatitis B Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D006521:Hepatitis, Chronic / Q000097:blood* / Q000150:complications; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012008:Recurrence
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens