Neuromuscular transmission and its blockade. Pharmacology, monitoring and physiology updated.
The role of two recently introduced muscle relaxants--atracurium and vecuronium--in contemporary anaesthetic practice is assessed. Recent advances in the physiology of neuromuscular transmission, particularly the roles of calcium and calmodulin, are reviewed, and new ideas concerning the reversal and monitoring of neuromuscular blockade are discussed.
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Jones
D000328:Adult; D000818:Animals; D002147:Calmodulin / Q000502:physiology; D002648:Child; D006439:Hemodynamics / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007223:Infant; D008991:Monitoring, Physiologic; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D002147:Calmodulin; D009466:Neuromuscular Blocking Agents