Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport.
A combination of cell-free biochemical and morphological studies has revealed that a coated bud-coated vesicle transport system shuttles newly synthesized proteins through the successive processing compartments of the Golgi apparatus. These Golgi-coated vesicles operate in a manner formally analogous to the clathrin-coated, pit-coated vesicle system responsible for receptor-mediated endocytosis; however Golgi-coated vesicles do not contain clathrin.
Rothman
J E
JE
Department of Molecular Biology, Princeton University, New Jersey 08544.
Orci
L
L
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology; D002474:Cell-Free System / Q000378:metabolism / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000502:physiology*