[The characteristics of the modulation of afferent reactions by adrenergic and cholinergic preparations and by the electrostimulation of the skin under conditions of changing atmospheric pressure].
The authors studied the organism's afferent reactions in changing conditions of atmospheric pressure in electrostimulation of skin zones during application of adren- and cholinergic agents. All of the studied adren- and cholinolytic agents facilitated the inhibition of afferent reactions, in contrast to mediation intensifying agents. The results of the experiments suggest that the nociceptive thresholds at atmospheric pressure of 550 mm Hg reduce, which may be linked with intensification of the catecholamine reactions of the organism of untrained animals. This is confirmed by the results of experiments with inderal injection, in which the effect of inhibition of the induced afferentation is most marked at pressure of 550 and 360 mm Hg. Besides, the analgesic activity of benactyzine diminished under similar conditions. Inderal and benactyzine potentiate the analgesic effect of percutaneous electroneurostimulation.
P M
PM
Pradkhan
D P
DP
Bilibin
O A
OA
Shevelev
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D004353:Drug Evaluation, Preclinical; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D010277:Parasympathomimetics / Q000627:therapeutic use*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D013566:Sympathomimetics / Q000627:therapeutic use*; D004561:Transcutaneous Electric Nerve Stimulation / Q000295:instrumentation / Q000379:methods*
D010277:Parasympathomimetics; D013566:Sympathomimetics
Osobennosti moduliatsii afferentnykh reaktsiĭ adren- i kholinergicheskimi preparatami i élektrostimuliatsieĭ kozhi v usloviiakh meniaiushchegosia atmosfernogo davleniia.