Association of polycystic kidney disease and an HLA haplotype within a family clan.
Nine members of a Chinese family underwent for HLA-A, -B. and -DR typing using microlymphocytotoxicity technique. The results of genotyping of the family showed that all four individuals who suffered from polycystic kidney disease shared the HLA-A9(Aw24), -Bw22, and -DR5 haplotype. It indicated that polycystic kidney disease was associated with an HLA haplotype in the family. We suggested that the HLA-A9(Aw24), -Bw22, -DR5 chromosome might carry the susceptibility gene of polycystic kidney disease in this family.
Institute of Urology, Beijing Medical University, People's Republic of China.
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D000328:Adult; D002648:Child; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens / Q000235:genetics*; D015805:HLA-DR5 Antigen / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D007690:Polycystic Kidney Diseases / Q000235:genetics*
D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens; C105903:HLA-B22 antigen; D015805:HLA-DR5 Antigen