[Effect of quinine, a blocker of Ca2+-activated K+-channels, on lymphocyte activation by mitogens].
Quinine inhibits mitogenesis at the same concentration (10(-4) M) as that which blocks Ca++-dependent potassium transport in lymphocytes. Lower quinine concentrations (10(-8)-10(-6) M) induce a comitogenic effect which is most pronounced when Ca++-ionophore A23187 is used as a mitogen. Thus, activation of Ca++-dependent K+-channels is not necessary to trigger mitogenesis, but is important for further stages of the process.
Riabichenko
V V
VV
Gukovskaia
A S
AS
Nikolaeva
I S
IS
Astashkin
E I
EI
D052160:Benzothiazoles; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002232:Carbocyanines / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005456:Fluorescent Dyes / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011803:Quinine / Q000494:pharmacology*
D052160:Benzothiazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; D007473:Ion Channels; D008934:Mitogens; D010835:Phytohemagglutinins; D003208:Concanavalin A; D000001:Calcimycin; C012944:3,3'-dipropyl-2,2'-thiadicarbocyanine; D004247:DNA; D011803:Quinine; D011188:Potassium; D002118:Calcium
Vliianie khinina, blokatora Ca2+-aktiviruemykh K+-kanalov, na aktivatsiiu limfotsitov mitogenami.