The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.
The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.
Sherr
C J
CJ
Rettenmier
C W
CW
Sacca
R
R
Roussel
M F
MF
Look
A T
AT
Stanley
E R
ER
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D002415:Cats; D002460:Cell Line; D003429:Cross Reactions; D004274:DNA, Recombinant; D000939:Epitopes; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009857:Oncogenes; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D016184:Receptors, Colony-Stimulating Factor; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D000911:Antibodies, Monoclonal; D004274:DNA, Recombinant; D000939:Epitopes; D006023:Glycoproteins; D007106:Immune Sera; D011956:Receptors, Cell Surface; D016184:Receptors, Colony-Stimulating Factor; D014764:Viral Proteins; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases