Effects of saltwater adaptation on serotonin metabolite concentrations in the cerebrospinal fluid of rainbow trout (Salmo gairdneri).
A new procedure was applied to rainbow trout for collecting cerebrospinal fluid (CSF). CSF was withdrawn continuously from the third ventricle at a flow rate of 0.7 microliter/min for up to 6 hr. The 5-HIAA concentrations in trout CSF are temperature-dependent and decrease exponentially after pargyline injection. The computed half-life of 5-HIAA production in CSF is 78 min at 15 degrees C. 5-HIAA concentrations in CSF are considered to reflect serotonin (5-HT) metabolism. The 5-HIAA content in the CSF of trout held in freshwater for several weeks is significantly higher than in trout held in either 1.6 or 3.0% saltwater while sodium content only exhibits a very slight change in the CSF of trout held in 3.0% saltwater. It is hypothesized that 5-HT could participate in the neurally-mediated adaptation to various osmotic conditions.
Mazeaud
M M
MM
Elghozi
J L
JL
Laude
D
D
Le Quan-Sang
K H
KH
D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D012487:Salmonidae / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D012964:Sodium / Q000134:cerebrospinal fluid; D014337:Trout / Q000134:cerebrospinal fluid / Q000502:physiology*; D014882:Water-Electrolyte Balance
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012964:Sodium