Griseofulvin-induced protoporphyria revisited.
In nude mice grieofulvin given by intraperitoneal injections produces a severe porphyric state within 1 week. Compared with peroral administration of griseofulvin to produce experimental porphyria, this model is much more efficient and can be more easily controlled.
Gederaas
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Department of Clinical Chemistry, University of Trondheim, University Hospital, Norway.
Brekke
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Romslo
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D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002853:Chromatography, Liquid; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000187:drug effects; D006118:Griseofulvin / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D012871:Skin Diseases / Q000139:chemically induced*
D011166:Porphyrins; D011524:Protoporphyrins; D006118:Griseofulvin