Modulation of substance P-induced bronchoconstriction by lipoxygenase metabolites.
In anaesthetized, mechanically ventilated guinea-pigs, substance P induces a bronchoconstrictor response comprising increases in airway resistance and decreases in dynamic compliance. Eicosatetraynoic acid (ETYA, 20 mg kg-1 i.v.) or BW755c (20 mg kg-1 i.v.) potentiated the substance P-induced bronchoconstriction. Neither indomethacin (1 or 5 mg kg-1 i.v.) nor aspirin (20 mg kg-1 i.v.) significantly altered the potency of substance P on bronchomotor responses. These observations are consistent with the existence of a bronchodilator lipoxygenase metabolite(s).
A G
AG
Stewart
D C
DC
Thompson
M R
MR
Fennessy
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism*; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D015117:5,8,11,14-Eicosatetraynoic Acid; D013373:Substance P; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin; D007213:Indomethacin