Postprandial pancreatic exocrine secretion in dogs after oral administration of pirenzepine dihydrochloride.
The effect of orally administered 1,5-dihydroxy-11-(4-methyl-1-piperazinyl)- acetyl-6H-pyrido[2,3-b]-1,4-benzodiazepin-6-one dihydrochloride (pirenzepine dihydrochloride, LS-519 Cl, Gastrozepin) on the postprandial secretion of pancreatic juice and the duodenal pH was studied in conscious dogs. An inhibition of the normal increase of the postprandial pancreatic secretion was observed. A possible indirect role of endogenous secretin and a cholinergic enteropancreatic reflex was discussed.
Madrid
J A
JA
Salido
G M
GM
Martinez de Victoria
E
E
Mañas
M
M
Mataix
F J
FJ
D000681:Amylases / Q000378:metabolism; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001639:Bicarbonates / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004285:Dogs; D004386:Duodenum / Q000378:metabolism; D004435:Eating; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010890:Pirenzepine; D011506:Proteins / Q000378:metabolism; D013997:Time Factors
D001570:Benzodiazepinones; D001639:Bicarbonates; D002712:Chlorides; D011506:Proteins; D010890:Pirenzepine; D000681:Amylases