Sequential chemotherapy for advanced epithelial ovarian cancer: platinum combination cytoreduction followed by cyclophosphamide consolidation.
Thirty-six women with advanced epithelial ovarian cancer were treated with a combination of cisplatin, vinblastine and bleomycin followed by a consolidation regimen of intravenous cyclophosphamide. There was a 53% response rate in previously untreated patients with 25% complete clinical remissions. Sixteen per cent of previously untreated patients remain in a complete clinical remission of greater than 3 yr duration. In a multivariate analysis bulk tumor residuum was not a significant adverse factor in terms of survival, suggesting that intensive chemical cytoreduction followed by non-cross-resistant consolidation may overcome such prognostic variables.
Lawton
F
F
Blackledge
G
G
Buckley
H
H
Johnson
R
R
Kelly
K
K
Crowther
D
D
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects
D001761:Bleomycin; D014747:Vinblastine; D003520:Cyclophosphamide; D002945:Cisplatin