A new class of endogenous human retroviral genomes.
Human DNA contains multiple copies of a novel class of endogenous retroviral genomes. Analysis of a human recombinant DNA clone (HLM-2) containing one such proviral genome revealed that it is a mosaic of retroviral-related sequences with the organization and length of known endogenous retroviral genomes. The HLM-2 long terminal repeat hybridized with the long terminal repeat of the squirrel monkey virus, a type D retrovirus. The HLM-2 gag and pol genes share extensive nucleotide sequence homology with those of the M432 retrovirus (a type A-related retrovirus), mouse mammary tumor virus (a type B retrovirus), and the avian Rous sarcoma virus (a type C retrovirus). Nucleotide sequence analysis revealed regions in the HLM-2 pol gene that were as much as 70 percent identical to the mouse mammary tumor virus pol gene. A portion of the putative HLM-2 env gene hybridized with the corresponding region of the M432 viral genome.
Callahan
R
R
Chiu
I M
IM
Wong
J F
JF
Tronick
S R
SR
Roe
B A
BA
Aaronson
S A
SA
Schlom
J
J
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics; D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D015683:Gene Products, gag; D005814:Genes, Viral; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D012190:Retroviridae / Q000145:classification / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
D000956:Antigens, Viral; D015683:Gene Products, gag; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase; D004262:DNA Restriction Enzymes