The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1.
The DNA sequence of the c-myc-regulated gene mrl (G. C. Prendergast and M. D. Cole, Mol. Cell. Biol. 9:124-134, 1989) reveals that it encodes plasminogen activator inhibitor 1 (PAI-1), a regulator of extracellular proteolysis. Comparison of the human and mouse PAI-1 promoters and cDNA 3' noncoding regions revealed several highly conserved sequence domains, potential targets for c-myc and other factors influencing PAI-1 expression. We discuss possible roles for PAI-1 in normal and neoplastic cell growth control.
Department of Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544-1014.
G C
GC
Prendergast
L E
LE
Diamond
D
D
Dahl
M D
MD
Cole
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005796:Genes; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc; D012689:Sequence Homology, Nucleic Acid; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc; D000979:alpha-2-Antiplasmin; D004247:DNA