Maitotoxin stimulates the formation of inositol phosphates in rat aortic myocytes.
Maitotoxin is the most potent of the known marine toxins. The effect of maitotoxin on muscle contraction or hormone release was consistent with its action on the voltage-sensitive channel. Indeed, calcium antagonists such as nifedipine or diltiazem were able to reverse the maitotoxin effects. Using smooth muscle cells, we have analysed the effects of maitotoxin on the inositol phosphate metabolism. Maitotoxin stimulates the inositol phosphate formation (5 +/- 1.8-fold in the presence of 10 mM LiCl). Moreover, this effect is not reversed, even partially by calcium antagonists, by alpha 1 antagonists and is not mimicked by Ca2+ ionophores such as A23187 or calcium agonists such as Bay-K 8644. The action of maitotoxin is further discussed in this paper.
P
P
Berta
F
F
Sladeczek
J
J
Derancourt
M
M
Durand
P
P
Travo
J
J
Haiech
D000818:Animals; D001011:Aorta; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002478:Cells, Cultured; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000378:metabolism*; D007473:Ion Channels / Q000502:physiology; D007700:Kinetics; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000378:metabolism*; D035964:Oxocins; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013403:Sugar Phosphates / Q000378:metabolism*; D000095702:Polyether Toxins
D002118:Calcium; D002121:Calcium Channel Blockers; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates; D007473:Ion Channels; D008387:Marine Toxins; D035964:Oxocins; D019269:Phosphatidylinositol 4,5-Diphosphate; D010716:Phosphatidylinositols; D013403:Sugar Phosphates; C020394:maitotoxin; D000095702:Polyether Toxins