Experience with the EndoPap device for the cytologic detection of uterine cancer and its precursors: a comparison of the EndoPap with fractional curettage or hysterectomy.
Cytologic assessment of the endometrium with the EndoPap sampler was compared with curettage or hysterectomy in 249 women with symptoms. The sensitivities for the detection of primary corpus cancer and hyperplasia were 0.90 (59/66) and 0.58 (18/31), respectively. All six cases of atypical endometrial hyperplasia were detected by the EndoPap device. Malignant EndoPap cytologic findings were present in 4 of 10 patients with a primary adnexal malignancy and normal endometrial histologic findings. Ninety-two percent of primary uterine cervical cancers were detected by EndoPap cytologic sampling. The specificity for the cytologic diagnosis of benign conditions was 0.93. EndoPap cytologic sampling has a reasonably high sensitivity for the detection of uterine cancers and preinvasive endometrial lesions with a high risk of progression to carcinoma. Further evaluation as to its usefulness in a screening program for uterine and adnexal cancers in postmenopausal women should be considered.
LaPolla
J P
JP
Department of Obstetrics and Gynecology, University of South Florida, Tampa.
Nicosia
S
S
McCurdy
C
C
Songster
C
C
Ruffolo
E
E
Roberts
W S
WS
Hoffman
M S
MS
Fiorica
J V
JV
Cavanagh
D
D
D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D004107:Dilatation and Curettage; D004714:Endometrial Hyperplasia / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D011230:Precancerous Conditions / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014626:Vaginal Smears / Q000295:instrumentation