Lack of correlation between titers of serum allergen-specific IgE and symptoms in untreated patients with seasonal allergic rhinitis.
In five ragweed seasons and three grass pollen seasons, preseason and postseason ragweed-specific serum IgE and nasal secretory-specific IgE and IgA have been measured in untreated patients with seasonal allergic rhinitis. There was no consistent correlation between severity of rhinitis, as measured by symptom/medication scores during the season, and either absolute or changes in antibody titers. These findings suggest that antibody levels are only one of the factors that determine symptom severity.
Nickelsen
J A
JA
Georgitis
J W
JW
Reisman
R E
RE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000918:Antibody Specificity; D000939:Epitopes; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis* / Q000276:immunology; D008875:Middle Aged; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D007071:Immunoglobulin A, Secretory; D007073:Immunoglobulin E