The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.
Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller than that of immunoglobulin heavy-chain or light-chain genes. We suggest that beta-chain somatic diversification is concentrated at the V beta-D beta-J beta junctions.
Barth
R K
RK
Kim
B S
BS
Lan
N C
NC
Hunkapiller
T
T
Sobieck
N
N
Winoto
A
A
Gershenfeld
H
H
Okada
C
C
Hansburg
D
D
Weissman
I L
IL
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes; D005786:Gene Expression Regulation; D005796:Genes; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D051379:Mice; D009154:Mutation; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000502:physiology*
D000939:Epitopes; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell