Triiodothyronine stimulates the production of insulin-like growth factor (IGF) by fetal hypothalamus cells cultured in serum-free medium.
Grown in serum-free medium, dissociated cells from fetal mouse hypothalami release insulin-like growth factors (IGFs) and their binding proteins (IGF BPs) into the culture medium. Addition of triiodothyronine (10-12-10-8 M), which enhances neuron maturation, resulted in a significant increase in IGF concentration. By contrast, there was no significant effect on IGF BP. These results suggest a role for thyroid hormone in the control of IGF biosynthesis in nerve cells.
Binoux
M
M
Faivre-Bauman
A
A
Lassarre
C
C
Barret
A
A
Tixier-Vidal
A
A
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis; D002478:Cells, Cultured; D003470:Culture Media; D005333:Fetus; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D018969:Insulin-Like Growth Factor Binding Proteins; D051379:Mice; D013002:Somatomedins / Q000096:biosynthesis*; D014284:Triiodothyronine / Q000494:pharmacology*
D002352:Carrier Proteins; D003470:Culture Media; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D014284:Triiodothyronine