Cytogenetic effects of radiotherapy: frequency and types of chromosome aberrations.
The frequency and types of chromosome aberrations induced by ionizing radiation in cancer patients were evaluated in 24 cases studied just before and immediately after radiotherapy. The incidence of aberrant metaphases prior to treatment was 9.98% and increased significantly after treatment to 32.8%. The frequency of chromosome aberrations before radiotherapy was, with the exception of the cases of breast cancer and seminoma, significantly higher than that in our laboratory controls. A comparison of chromosome abnormalities observed before and after treatment indicated that dicentric translocations, rings, and reciprocal translocations increased by a factor of 23, 13, and 11, respectively, after radiotherapy. Ionizing radiation produces more asymmetrical than symmetrical chromosome aberrations and more two-break than one-break anomalies.
Departament de Biologia Cellular i Fisiologia, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
L
L
Barrios
M R
MR
Caballín
R
R
Miró
C
C
Fuster
F
F
Guedea
A
A
Subias
J
J
Egozcue
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000532:radiotherapy; D002869:Chromosome Aberrations; D004407:Dysgerminoma / Q000235:genetics / Q000532:radiotherapy; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D013736:Testicular Neoplasms / Q000235:genetics / Q000532:radiotherapy; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000532:radiotherapy