[Experimental research on the effect of bioshik (tinidazole) on reproduction indices].
Studies were carried out on the influence of bioshik (tinidazol), synthesised and produced by NPSK of Pharmacy at the Medical Academy on reproduction of male and female rats. The experiments were undertaken after oral administration of bioshik in two doses of 100 mg and 300 mg/kg of body mass (1/20 and 1/10 of LD50) at several stages: I stage during natal application, respectively: 1. during sexual maturation and 2. during the period of sexual maturity and II stage during prenatal administration of bioshik. The studies of the second stage were performed on 3-months old male and female rats, a generation of animals, treated with bioshik during pregnancy. The following parameters were determined: sexual receptivity, reproduction, percentage of early resorptions and mean number of normally implanted fetuses. The described data showed that there was inhibition of sexual receptivity as well as of reproduction after usage of higher doses of 300 mg/kg of body mass only natally and more manifested after application during sexual maturation. There were no data on impairement of the examined parameters for reproduction in offsprings after treatment of pregnant rats with bioshik.
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Boiadzhieva
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009593:Nitroimidazoles / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D014011:Tinidazole / Q000494:pharmacology*
D009593:Nitroimidazoles; D014011:Tinidazole
Eksperimentalni prouchvaniia na vliianieto na bioshik (tinidazol) vŭrkhu niakoi pokazateli za reproduktivnost.