Fibroblast growth factor in chick osteogenesis.
In vivo effects of FGF on osteogenesis in the chick embryo were evaluated. Day-11 embryos were injected with FGF followed by radiotracers. 3H-thymidine labelling of osteogenic cells was significantly higher following FGF administration; 3H-proline labelling over bone matrix was greater in the controls. Cartilage cells and matrix were sparsely labelled indicating a low level of metabolic activity. These data provide the first in vivo evidence that FGF stimulates osteogenic cell proliferation, while inhibiting production of bone matrix collagen. A role for FGF in embryonic osteogenesis and in fracture repair is suggested.
Hospital for Joint Diseases Orthopaedic Institute, New York, NY.
S R
SR
Frenkel
D A
DA
Grande
M
M
Collins
I J
IJ
Singh
D000818:Animals; D001345:Autoradiography; D002642:Chick Embryo; D005346:Fibroblast Growth Factors / Q000494:pharmacology* / Q000502:physiology; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology
D005346:Fibroblast Growth Factors