Immunogenic potentials of copolymer I in normal human lymphocytes.
Copolymer I (COP I), a nonencephalitogenic polypeptide analogous to myelin basic protein, is currently being tested for possible effectiveness in treating MS. Peripheral blood mononuclear cells from normal human donors respond blastogenically to the L-form of COP I. This response was greater than that obtained with either bovine or guinea pig myelin basic protein (GPMBP), with no specificity for a particular T-cell subset. Analyses of culture supernatants demonstrated the presence of interleukin-2 and gamma interferon. Mononuclear cells from human fetal cord blood also responded blastogenically to COP I, but the magnitude of the response did not differ from that induced by GPMBP.
Brosnan
C F
CF
Litwak
M
M
Neighbour
P A
PA
Lyman
W D
WD
Carter
T H
TH
Bornstein
M B
MB
Bloom
B R
BR
D000818:Animals; D000941:Antigens / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D010455:Peptides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology
D000941:Antigens; D008222:Lymphokines; D004676:Myelin Basic Protein; D010455:Peptides; C021759:(T,G)-A-L