Investigations into the identity of the non-adrenergic, non-cholinergic excitatory transmitter in the smooth muscle of chicken rectum.
ATP and substance P were examined as possible mediators of non-adrenergic, non-cholinergic excitatory transmission in chicken rectum. ATP and the non-degradable ATP analogue, alpha, beta-methylene ATP, mimicked the response to nerve stimulation. Substance P either produced a maintained contraction after a long latency or was inactive. After desensitization of the P2-purinoceptor by alpha, beta-methylene ATP, the responses to ATP and nerve stimulation were abolished, while the response to carbachol was little affected. It is concluded that ATP may be the transmitter in non-adrenergic, non-cholinergic excitatory nerves supplying the chicken rectum.
Meldrum
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LA
Burnstock
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D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002645:Chickens; D004553:Electric Conductivity / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D012007:Rectum / Q000502:physiology; D013373:Substance P / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D018377:Neurotransmitter Agents; D013373:Substance P; D013779:Tetrodotoxin; D001285:Atropine; D000255:Adenosine Triphosphate; D002217:Carbachol; C002630:alpha,beta-methyleneadenosine 5'-triphosphate