[Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration].
A single intravenous injection of 30-50 mg ethacizin produces a favourable antiarrhythmic effect in 80-85% of patients with ventricular disorders of cardiac rhythm. The drug's action already begins "on the needle", reaches its peak within 3-5 minutes and lasts for 1-2 hours. A two-compartment model adequately represents ethacizin pharmacokinetics. The average ethacizin half-distribution and half-elimination periods are 4.7 and 154.4 minutes, respectively, and its clearance rate is 0.99 1/min. Therapeutic plasma concentration of the drug varies between 30-50 and 300-400 ng/ml.
Kh Kh
KhKh
Shugushev
E T
ET
Gneushev
A S
AS
Smetnev
V G
VG
Kukes
L V
LV
Rozenshtraukh
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood*; D005117:Cardiac Complexes, Premature / Q000097:blood / Q000188:drug therapy; D002853:Chromatography, Liquid; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D016293:Moricizine / Q000031:analogs & derivatives*; D010640:Phenothiazines / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
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