Kainic acid responses and toxicity show pronounced Ca2+ dependence.
Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.
Hori
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Ffrench-Mullen
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JM
Carpenter
D O
DO
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D007478:Iontophoresis; D007608:Kainic Acid / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats
D007473:Ion Channels; D010069:Oxadiazoles; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D008274:Magnesium; D007608:Kainic Acid; D002118:Calcium