The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model.
Topical non-steroidal anti-inflammatory drugs may serve as an alternative or adjunct to topical corticosteroid therapy for iritis. We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha. Topically administered S(+)-ibuprofen was found to inhibit increased vascular permeability associated with this model. These results with topical S(+)-ibuprofen compare favorably to the results seen with topical prednisolone and are significantly superior to the results seen with topical flurbiprofen. Topical S(+)-ibuprofen did not significantly reduce the cellular infiltration associated with interleukin-1 induced inflammation. These findings suggest a potential role for topical S(+)-ibuprofen in the treatment of ocular inflammation and, in this animal model, it appears to be superior to an alternative non-steroidal compound, but further studies are indicated to assess its activity in alternate models of ocular inflammation.
Department of Ophthalmology, Oregon Health Sciences University, Portland.
M E
ME
Tilden
R S
RS
Boney
M M
MM
Goldenberg
J T
JT
Rosenbaum
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000166:cytology / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D002452:Cell Count; D004195:Disease Models, Animal; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007375:Interleukin-1; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011817:Rabbits; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*
D005136:Eye Proteins; D007375:Interleukin-1; D005480:Flurbiprofen; D011239:Prednisolone; D007052:Ibuprofen