A specific S-antigen of Plasmodium falciparum is expressed in a proportion of primary isolates in Brazil, Thailand and Papua New Guinea.
The expression by Plasmodium falciparum of a specific S-antigen has been examined in primary isolates in different regions of the world using a monoclonal antibody that recognizes an epitope within a known repeated amino acid sequence. The epitope was expressed by a small proportion of primary isolates in each of Brazil, Thailand and Papua New Guinea, demonstrating that this S-antigen gene is widespread. The data are consistent with the possibility that the occurrence of P. falciparum strains expressing a particular S-antigen is periodic, related to the duration of immunity against that antigen in a given human population.
Schofield
L
L
Tharavanij
S
S
Saul
A
A
do Rosario
V
V
Kidson
C
C
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000953:Antigens, Protozoan / Q000032:analysis*; D001938:Brazil; D000939:Epitopes; D006801:Humans; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000276:immunology* / Q000302:isolation & purification; D013785:Thailand
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D000939:Epitopes; C047712:S-antigen, Plasmodium falciparum