[Comparative antivitamin activity of oxythiamine disulfide and its monosulfoxide].
The B1-antivitamin activity of oxythiamine disulphide monosulphoxide has been determined in experiments on albino mice. It is shown that this derivative is less toxic and exerts a more profound and prolonged inhibitory action on the pyruvate dehydrogenase and transketolase activity in the animal body in comparison with initial oxythiamine disulphide.
T I
TI
Zimatkina
D A
DA
Oparin
D000818:Animals; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology; D010119:Oxythiamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D013831:Thiamine / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors
D011768:Pyruvate Dehydrogenase Complex; D013844:Thiazoles; C065620:oxythiamine disulfide monosulfoxide; C065622:oxythiamine disulfide; D010119:Oxythiamine; D014174:Transketolase; D013831:Thiamine
Sravnitel'naia antivitaminnaia aktivnost' oksitiamindisul'fida i ego monosul'foksida.