Vitamin A in cystic fibrosis: case report and review of the literature.
Much has been learned about vitamin A physiology in the last 50 years, yet few changes have been made in therapy. Unfamiliarity with vitamin A bioavailability and distribution may inadvertently result in toxicity. A literature search demonstrates that hypovitaminosis A has rarely been reported in patients with cystic fibrosis, and may manifest very differently in children of different ages. Furthermore, hypervitaminosis A may present with similar features, and can result from correction of deficiency. We report such a case in a 4.5-month-old infant, newly diagnosed with cystic fibrosis, who suffered first from vitamin A deficiency and then vitamin A toxicity. A brief review of vitamin A physiology, deficiency, and toxicity is presented.
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Department of Pediatrics, University of Louisville School of Medicine, Kentucky.
Shoemaker
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LR
Samiec
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D001682:Biological Availability; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D006986:Hypervitaminosis A / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D007223:Infant; D008297:Male; D014801:Vitamin A / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism
D014801:Vitamin A