[Evaluation of liposomal forms of rifampicin and prodigiozan in the treatment of experimental chronic tonsillitis].
Therapeutic effect of liposomal dosages of rifampicin and prodigiozan was studied on rabbits with simulated chronic tonsillitis in comparison to that of commercial ones of the drugs. The treatment schemes included daily intra-tonsillar++ injections of the dosage forms for 5 days. A high efficacy of their liposomal dosage forms in treatment of experimental chronic tonsillitis was confirmed microbiologically and immunologically. Approval of the liposomal dosage forms used in the therapy of patients with chronic tonsillitis requires clinical trials.
Tsyganenko
A Ia
AIa
Filatov
V F
VF
Dikiĭ
I L
IL
Iakovenko
V D
VD
Vasil'chenko
V N
VN
Bazavluk
A D
AD
D000276:Adjuvants, Immunologic; D000818:Animals; D002908:Chronic Disease; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008081:Liposomes; D014066:Palatine Tonsil / Q000187:drug effects / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D011354:Prodigiozan / Q000008:administration & dosage*; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage*; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000276:immunology; D014069:Tonsillitis / Q000188:drug therapy* / Q000276:immunology
D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D008081:Liposomes; D011135:Polysaccharides, Bacterial; D011354:Prodigiozan; D012293:Rifampin
Otsenka liposomal'nykh form rifampitsina i prodigiozana pri lechenii éksperimental'nogo khronicheskogo tonzillita.