Mammary ovarian metastases with stroma cell hyperplasia and postmenopausal virilization.
The case of a 57-year-old woman with a history of breast cancer is reported. She presented 10 years later with virilization. Stroma cell hyperplasia was present in the metastatic ovaries. The authors describe hormonal data and discuss the pathogenesis of the stromal activity. Mammary ovarian metastases associated with stroma cell hyperplasia, in the absence of pregnancy, that cause virilization are rare.
Service d'Endocrinologie, Clinique Dieulafoy, CHU Purpan, Toulouse, France.
P
P
Caron
H
H
Roche
B
B
Gorguet
P
P
Martel
A
A
Bennet
M
M
Carton
D019326:17-alpha-Hydroxyprogesterone; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000097:blood / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D006965:Hyperplasia; D008593:Menopause; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology / Q000556:secondary*; D010053:Ovary / Q000473:pathology; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000209:etiology*
D006908:Hydroxyprogesterones; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone