Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets.
The effects of substance P (SP) and SP-(6-11) (SP6-11) on hormone secretion from the isolated perfused pancreas were compared in rats and dogs under the same conditions. In the rat, SP inhibited insulin secretion in a dose-dependent manner in a concentration range of 0.1-10 nM. Glucagon secretion was inhibited at a minimal dose of 10 nM SP. No significant effect on somatostatin secretion was obtained. SP6-11 exhibited the identical inhibitory potency as SP on both insulin and glucagon release from the rat pancreas. In the canine pancreas, by contrast, 1 and 10 nM SP and SP6-11, respectively, potentiated the release of insulin, glucagon, and somatostatin. Potentiation by SP6-11 was less than that by SP. These results demonstrate species differences in the effects of SP and SP6-11 on the release of pancreatic hormones.
Chiba
Y
Y
Kawai
K
K
Okuda
Y
Y
Munekata
E
E
Yamashita
K
K
D000818:Animals; D004285:Dogs / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000378:metabolism; D013045:Species Specificity; D013373:Substance P / Q000494:pharmacology*
D007328:Insulin; D010446:Peptide Fragments; D013373:Substance P; D013004:Somatostatin; D005934:Glucagon