Dihydropyridine BAY K 8644 enables reduction of Ca concentration to induce catecholamine secretion from the perfused cat adrenal.
Dihydropyridine derivative BAY K 8644 increased the rate of catecholamine secretion from the perfused cat adrenal. The magnitude of the response was inversely proportional to the extracellular concentration of Ca, i.e. the lower the Ca concentration, the larger the response. The response was markedly inhibited by Mg or nifedipine.
Sorimachi
M
M
Nishimura
S
S
Yano
K
K
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002415:Cats; D008274:Magnesium / Q000494:pharmacology; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010477:Perfusion
D002395:Catecholamines; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D008274:Magnesium; D009543:Nifedipine; D002118:Calcium