The effect of gossypol on fast axonal transport and microtubule assembly.
Gossypol at micromolar concentrations (2 microM) was found to inhibit axonal transport and a microsomal ATPase activity in the frog sciatic nerve, although axonal microtubules and the neuronal content of AMP, ADP and ATP were not affected. At slightly higher concentrations (30-40 microM), gossypol also inhibited microtubule assembly and neuronal energy metabolism. Gossypol accumulated in the nerve and the results indicate that gossypol may act as a potent neurotoxin.
Kanje
M
M
Ekström
P
P
Deinum
J
J
Wallin
M
M
D000251:Adenosine Triphosphatases / Q000032:analysis; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D006072:Gossypol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008870:Microtubules / Q000187:drug effects*; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000201:enzymology
D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D006072:Gossypol