Antimutagenicity profiles for some model compounds.
The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for application to antimutagenicity data. The activity profiles are bar graphs that have been organized in two general ways: for antimutagens that have been tested in combination with a given mutagen and for mutagens that have been tested in combination with a given antimutagen. Doses from both the mutagen and the antimutagen are displayed and plotted together with results on enhancement or inhibition of mutagenic activity. The short-term tests that have been used extensively to identify mutagens and potential carcinogens are increasingly being used to identify antimutagens and potential anticarcinogens. Three model mutagens, N-methyl-N'-nitro-N-nitrosoguanidine, aflatoxin B1 and benzo[a]pyrene, and 4 model antimutagens, butylated hydroxyanisole, butylated hydroxytoluene, glutathione and disulfiram, were selected from the data surveyed in the published literature. It is not clear at the present time whether the inhibition of carcinogen-induced mutation is a good indicator of anticarcinogenic properties, and further research is needed. Nevertheless, the activity profiles are useful for the assessment of the available antimutagenesis data by providing rapid visualization of considerable dose information and experimental results.
Waters
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U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Brady
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Stack
H F
HF
Brockman
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HE
D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D012486:Salmonella typhimurium / Q000235:genetics
D002273:Carcinogens; D009153:Mutagens