Effect of vitamin E deficiency on oxidative metabolism and antioxidant enzyme activity of macrophages.
In AUG rats, deprived of vitamin E for 90 days, we noted a 3-fold increase of kinetic parameters of luminol-dependent chemiluminescence of macrophages, stimulated with opsonized zymosan, superoxide dismutase activity decrease and increment of plasma membrane lipid bilayer microviscosity, which was estimated by fluorescent probe pyrene eximerization method. Vitamin E deficiency did not affect glutathione peroxidase and glutathione reductase activities of macrophages.
Sharmanov
A T
AT
Institute of Physiology, Kazakh Academy of Sciences, WHO Collaborating Centre on Nutrition, Alma-Ata, USSR.
Aidarkhanov
B B
BB
Kurmangalinov
S M
SM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D005609:Free Radicals; D005980:Glutathione Reductase / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000097:blood / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D013482:Superoxide Dismutase; D005980:Glutathione Reductase