Release of cold-induced burning pain by block of cold-specific afferent input.
While the pure sensation of cold is evoked by activation of a specific set of afferent channels, an additional set is believed to be activated by noxious low-temperature stimuli evoking cold pain. At primary afferent level, the channels concerned with the cold fraction of cold pain are served by myelinated A delta cold-specific fibres, whereas those concerned with the pain fraction are served by unmyelinated C nociceptors. In the present study, interaction between the two types of afferent input underlying cold pain was investigated by selectively blocking conduction in myelinated fibres. When doing so to the point of abolishing cold sensation, ramps of low-temperature stimuli eventually evoked a first sensation of burning pain. In addition to, and contemporaneous with, this change in quality, a significant decrease in pain threshold (reduction in required stimulus energy) was recorded when applying a noxious low-temperature stimulus. Such exaggeration in magnitude of low temperature-induced pain and the unmasking of its burning quality by A fibre block imply release of central sensory transmission due to removal of inhibitory primary afferent input. Myelinated fibres transmitting either tactile, cold sensations or both could exert this inhibition. Previous evidence of suppression of pain by low-temperature stimuli indicates that it is the cold-specific input that normally exerts this central gating on nociceptor input. The present results may also offer an explanation for the occurrence of a syndrome of burning pain on cold exposure in neuropathic patients with impaired ability to perceive cold.
Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, Oregon.
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Yarnitsky
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Ochoa
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology*; D001132:Arm / Q000294:innervation; D003080:Cold Temperature / Q000009:adverse effects; D005260:Female; D006801:Humans; D007511:Ischemia; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D010146:Pain / Q000209:etiology / Q000503:physiopathology; D059408:Pain Management; D012677:Sensation