Continuous inhibition of platelet S2-serotonergic receptors during chronic administration of ketanserin in humans.
Platelet aggregation induced by serotonin in plasma obtained from 9 volunteers was inhibited at 90 min and 15 h after the oral administration of ketanserin, either acutely or after one week of chronic administration. At 7 days after the last dose, a transient overreaction to serotonin occurred. Platelet reactions to epinephrine, collagen and adenosine diphosphate were not affected by ketanserin. The present results demonstrate a continuous inhibition of S2-serotonergic receptors in platelets during both acute and chronic treatment with ketanserin in humans.
De Clerck
F
F
Xhonneux
B
B
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007650:Ketanserin; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013997:Time Factors
D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D000244:Adenosine Diphosphate; D003094:Collagen; D007650:Ketanserin; D004837:Epinephrine