Expression of the c-fms proto-oncogene during human monocytic differentiation.
The McDonough strain of the feline sarcoma virus contains a transforming gene (v-fms) which contains partial nucleotide homology with proto-oncogenes encoding tyrosine kinases. One of the v-fms-encoded products, gp140fms, is a cell surface transmembrane glycoprotein that may function as a growth factor receptor. Although c-fms transcripts have been detected in placental trophoblasts and normal human bone marrow, the role of the c-fms gene product is unknown. We now report that induction of monocytic, but not granulocytic, differentiation of human HL-60 leukaemic cells is associated with expression of c-fms, preceded by that of c-myc and c-fos. Because c-fms transcripts are also detectable in peripheral blood monocytes and in blasts from certain patients with myelomonocytic leukaemia, the c-fms gene product may play a role in monocytic differentiation.
Sariban
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Mitchell
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Kufe
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D000081:Acetamides / Q000494:pharmacology; D002454:Cell Differentiation; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006410:Hematopoiesis; D006801:Humans; D007951:Leukemia, Myeloid; D009000:Monocytes / Q000166:cytology*; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D012313:RNA / Q000032:analysis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
D000081:Acetamides; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012313:RNA; D003513:Cycloheximide; C014026:hexamethylene bisacetamide; D013755:Tetradecanoylphorbol Acetate; D004121:Dimethyl Sulfoxide