Changes in ribonuclease in the central nervous system of mice during morphine dependence development, withdrawal and naloxone administration.
Ribonuclease has been studied in the whole brain homogenate of mice after a single dose of morphine (10 mg/kg), during the development of tolerance and dependence, during the course of withdrawal and naloxone administration. The enzyme increased dose dependently following the administration of morphine. Withdrawal caused a sudden fall in the enzyme with partial recovery by the 6th day of abstinence. Naloxone injections in normal, tolerant, dependent and deprived animals caused a reduction in the enzyme level. The morphine-induced increase in enzyme activity is suggested to be in direct correlation with a reduction in protein synthesis which can be ascribed to a disturbance of the translation processes.
Mohanakumar
K P
KP
Sood
P P
PP
D000818:Animals; D001921:Brain / Q000201:enzymology*; D051379:Mice; D009021:Morphine Dependence / Q000201:enzymology*; D009270:Naloxone / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000032:analysis; D012260:Ribonucleases / Q000032:analysis*; D013375:Substance Withdrawal Syndrome / Q000201:enzymology*
D009270:Naloxone; D012313:RNA; D012260:Ribonucleases