Sulphonamide residues in milk of dairy cows following intravenous injection.
An investigation was conducted into the elimination into milk of four sulphonamides (sulphadimidine, sulphamethoxypyridazine, sulphadimethoxine and sulphadoxine) after intravenous injections of drugs available in France. Sulphonamide determination in milk was performed using a high-performance liquid chromatography (HPLC) method with detection limit of 0.01 micrograms/ml. These results were used to determine the withdrawal times (two to six milkings) required for these drugs with a tolerance of 0.1 micrograms/ml as proposed by the European countries.
Roudaut
B
B
Ministère de l'Agriculture et de la Forêt, Centre National d'Etudes Vétérinaires, Alimentaires, Fougères, France.
Moretain
J P
JP
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005504:Food Analysis; D005506:Food Contamination; D005602:France; D007275:Injections, Intravenous; D008892:Milk / Q000032:analysis*; D013412:Sulfadimethoxine / Q000032:analysis; D013413:Sulfadoxine / Q000032:analysis; D013418:Sulfamethazine / Q000032:analysis; D013421:Sulfamethoxypyridazine / Q000032:analysis; D013449:Sulfonamides / Q000008:administration & dosage / Q000032:analysis*
D013449:Sulfonamides; D013412:Sulfadimethoxine; D013418:Sulfamethazine; D013413:Sulfadoxine; D013421:Sulfamethoxypyridazine