The effect of long-term prostacyclin treatment on the protein, DNA and RNA content of rat gastric fundic mucosa.
The changes of gastric fundic mucosal protein, DNA and RNA content have been investigated during long-term (40 and 80 days respectively), prostacyclin treatment. It seems that a longer prostacyclin treatment induces a significant thickening of the gastric fundic mucosa. This phenomenon might be explained by the hyperplasia of matured cells. This assumption is strengthened by the results obtained checking the DNA and RNA-levels of the mucosa.
G A
GA
Balint
G
G
Karácsony
V
V
Varró
D000818:Animals; D004247:DNA / Q000378:metabolism*; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D007213:Indomethacin; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism*; D013312:Stress, Physiological / Q000150:complications
D011506:Proteins; D012313:RNA; D004247:DNA; D011464:Epoprostenol; D007213:Indomethacin