Retarded recovery of excitability and twitches of frog toe muscles after K-induced depolarization (slow inactivation) in the presence of alkyl amphipaths.
Alkyl amphipaths resemble conventional local anesthetics in their ability to retard the recovery of excitability and twitch tension after depolarization at high Ko, an effect that is attributed to slow inactivation of potential-dependent sodium channels. The similar effect of low temperature offers an explanation for its ability to enhance the frequency-dependent effects of these agents.
J G
JG
Foulks
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L
Morishita
D020003:1-Octanol; D000200:Action Potentials / Q000187:drug effects; D000476:Alkanesulfonates / Q000494:pharmacology; D017738:Alkanesulfonic Acids; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D000442:Octanols / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D011343:Procaine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011894:Rana pipiens; D013696:Temperature; D013997:Time Factors
D000476:Alkanesulfonates; D017738:Alkanesulfonic Acids; D000779:Anesthetics, Local; D007473:Ion Channels; D009467:Neuromuscular Depolarizing Agents; D000442:Octanols; D000644:Quaternary Ammonium Compounds; D011343:Procaine; C042005:1-octanesulfonic acid; D020003:1-Octanol; D011188:Potassium