Major childhood tumor resection using normovolemic hemodilution anesthesia and hetastarch.
Acute normovolemic hemodilution is a safe technique for minimizing operative blood loss during major tumor resection in children. Based on our experience using hemodilution anesthesia in 14 successful extensive tumor resections, we conclude the following: (1) this is an effective means of reducing use of bank blood and thus avoiding the risks of multiple transfusions; (2) it facilitates surgical dissection due to increased visibility with dilute blood, and decreased bleeding due to controlled hypotension; (3) this technique is acceptable for Jehovah's Witnesses; (4) hetastarch is an effective, inexpensive colloid hemodiluent which minimized perioperative edema compared to crystalloid hemodilution.
Adzick
N S
NS
deLorimier
A A
AA
Harrison
M R
MR
Glick
P L
PL
Fisher
D M
DM
D000293:Adolescent; D000367:Age Factors; D000768:Anesthesia, General; D001810:Blood Volume; D002648:Child; D002675:Child, Preschool; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000601:surgery*; D013213:Starch / Q000031:analogs & derivatives
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch