Hydrogeologic assessment of exposure to solvent-contaminated drinking water: pregnancy outcomes in relation to exposure.
We recently concluded that exposure to solvent-contaminated drinking water was an unlikely explanation for observed excesses of adverse pregnancy outcomes during 1980-1981 in the Los Paseos neighborhood of Santa Clara County, California, because these excesses were not observed in an adjacent exposed area. The validity of this conclusion depends on the assumption that the two areas had comparable exposure. Using quantitative methods to model movement of the solvent leak plume and water flow within the distribution system, we estimated that women with adverse outcomes were no more likely to have received contaminated water than women with normal live births. These results strengthen the conclusion that exposures to water from the contaminated well were not responsible for the excess of adverse outcomes observed in the Los Paseos area.
Department of Epidemiology and Biostatistics, University of California, San Francisco.
M
M
Wrensch
S
S
Swan
P J
PJ
Murphy
J
J
Lipscomb
K
K
Claxton
D
D
Epstein
R
R
Neutra
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000022:Abortion, Spontaneous / Q000139:chemically induced* / Q000453:epidemiology; D002140:California; D016000:Cluster Analysis; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D008962:Models, Theoretical; D011247:Pregnancy; D011256:Pregnancy Outcome; D014240:Trichloroethanes / Q000009:adverse effects / Q000032:analysis*; D014872:Water Movements; D014877:Water Pollution, Chemical / Q000009:adverse effects / Q000032:analysis*
D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes