Urinary amine metabolite excretion in a patient with adrenergic hyperactivity state: reaction to phenelzine withdrawal and combined treatment.
Urinary MHPG (3-methoxy-4-hydroxyphenylglycol) amounts increased threefold during a toxic delirious state in a 57-year-old bipolar patient 3 days after phenelzine treatment was stopped. This norepinephrine metabolite was not expected to rise as monoamine oxidase (MAO) was completely blocked. In addition, the delirious state appeared as a rebound phenomenon and not an acute toxic state during drug administration. It seems that phenelzine acts more through catecholamine release phenomenon than by inhibition of MAO.
I
I
Modai
Y
Y
Beigel
G
G
Cygielman
D001714:Bipolar Disorder / Q000188:drug therapy; D003693:Delirium / Q000139:chemically induced* / Q000652:urine; D006018:Glycols / Q000652:urine*; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008676:Metanephrine / Q000652:urine; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D010624:Phenelzine / Q000009:adverse effects* / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000652:urine
D006018:Glycols; D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D010624:Phenelzine; D009638:Norepinephrine; D006719:Homovanillic Acid