Diorganotin dihalide complexes of 2,2'-biimidazole. A preliminary study of their inhibitory effects on cell division.
We report the synthesis of new complexes with the general formula (R2SnX2)y.H2BiIm, where y = 1 or 2; R = Me, Et, Bun; X = Cl or Br (for R = Et) and H2BiIm = 2,2'-Biimidazole. The complexes have been characterized by elemental analysis and Mössbauer, infra-red and 1H n.m.r. spectroscopy and tested (like the ligand, Me2SnCl2 and Et2SnCl2) against P388D1 leukemic cells.
Sánchez González
A
A
Departamento de Química Inorgánica, Universidad de Santiago de Compostela, Spain.
Casas
J S
JS
Sordo
J
J
Russo
U
U
Lareo
M I
MI
Regueiro
B J
BJ
D000818:Animals; D000970:Antineoplastic Agents; D002455:Cell Division / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D006219:Halogens / Q000138:chemical synthesis / Q000494:pharmacology*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008811:Mice, Inbred DBA; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006219:Halogens; D007093:Imidazoles; D009947:Organotin Compounds; C065541:2,2'-biimidazole; C027282:diethyltindichloride