[Interferon-inducing and antiviral effects of inosiplex in combination with high-molecular interferon inducers].
It has been shown that the immunostimulant inosiplex (IP) is capable of inducing interferon production in mice and of stimulating interferon induction by high-molecular inducers. The combined use of IP and poly (G)-poly (C) or dsRNA (RFf2) leads to a longer interferon circulation in the blood. All the combination schemes ensuring the effect of interferon production prolongation were tested for anti-viral activity. The prophylactic administration of the drugs permitted the attainment in mice of the increased resistance to experimental influenza.
E B
EB
Tazulakhova
N N
NN
Amitina
F I
FI
Ershov
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control; D011066:Poly C / Q000494:pharmacology; D011068:Poly G / Q000494:pharmacology; D012330:RNA, Double-Stranded / Q000494:pharmacology; D013994:Tilorone / Q000494:pharmacology
D000998:Antiviral Agents; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D007288:Inosine; D013994:Tilorone; D007542:Inosine Pranobex
Interferonindutsiruiushchiĭ i protivovirusnyĭ éffekty inozipleksa v kombinatsii s vysokomolekuliarnymi induktorami interferona.