[Effect of nicotine on auditory functions in the rat, studied by electrocochleography and auditory evoked potentials of the brain stem].
The rôle of nicotine (100 micrograms/kg) on brainstem auditory evoked responses (FFP) and electrocochleography (EcoG) in rats anaesthetized with pentobarbital has been studied. Each component of FFP and EcoG was analysed in terms of its latency and amplitude. Nicotine failed to produce any significant changes in the latencies of the FFP and EcoG components. Nicotine after 30 min increases significantly the amplitude I, I', II and III, of the FFP components, and decreases no significantly IV and V components. These finding suggests the presence of muscarinic and nicotinic effect of nicotine, in the mediation of the brainstem auditory pathway.
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de Lavernhe-Lemaire
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Garand
D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D003051:Cochlea / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009538:Nicotine
Effet de la nicotine sur les fonctions auditives du rat, exploré par électrocochléographie et potentiels évoqués auditifs du tronc cérébral. Travail préliminaire.