Premenstrual syndrome in three generations responds to antidepressants.
The author identified the clinical picture of 11 patients with premenstrual complaint in a genealogical tree spanning three generations. Seven patients who satisfied criteria for premenstrual syndrome (PMS) were treated successfully with amitriptyline. The possible role of antidepressant treatment for PMS is discussed. The possibility is raised of genetic predisposition in some subtypes of PMS, particularly those in which depression is a feature.
Department of Psychological Medicine, Otago Area Health Board, Dunedin, New Zealand.
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Taghavi
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D011293:Premenstrual Syndrome / Q000188:drug therapy / Q000235:genetics*; D012307:Risk Factors
D000639:Amitriptyline