Influenza virus hemagglutinin-binding T cells in delayed hypersensitivity induced in mice.
The ability of spleen T cells from mice inoculated with influenza virus to transfer delayed hypersensitivity increases after 5 days culture in the presence of TCGF and influenza virus or its hemagglutinin. Enriched T cells have also a greater ability to bind viral hemagglutinin than cells which were not cultured and restimulated with either antigen. The results suggest the selection in vitro of specific antigen-binding T cells, able to transfer delayed hypersensitivity.
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D000818:Animals; D002478:Cells, Cultured; D000939:Epitopes; D006389:Hemagglutinins, Viral / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D007376:Interleukin-2 / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006389:Hemagglutinins, Viral; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell