A study on the pharmacokinetics in mouse of adenine-9-beta-D-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin.
In plasma of mice injected with adenine-9-beta-D-arabinofuranoside monophosphate (ara-AMP) coupled to human lactosaminated serum albumin (L-HSA) some of the ara-AMP molecules are enzymatically released, whereas others remain linked to L-HSA. Evidence has been obtained that ara-AMP is not deaminated when it is conjugated to L-HSA, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.
L
L
Fiume
B
B
Bassi
C
C
Busi
A
A
Mattioli
T
T
Wieland
D000818:Animals; D001088:Arabinonucleotides / Q000378:metabolism*; D003070:Coformycin / Q000031:analogs & derivatives / Q000494:pharmacology; D006509:Hepatitis B / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D051379:Mice; D015649:Pentostatin; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000378:metabolism*; D001084:Vidarabine Phosphate / Q000378:metabolism*
D001088:Arabinonucleotides; D012709:Serum Albumin; C046912:lactosaminated serum albumin; D001084:Vidarabine Phosphate; D003070:Coformycin; D015649:Pentostatin