Differences in the actions of organic and inorganic Ca2+-antagonists on the inactivation of the Ca2+ channel in a molluscan neurone.
The actions of organic and inorganic Ca2+-antagonists on an inactivation of the Ca2+ channel was studied in molluscan neurones using a suction pipette technique. Both Ca2+-antagonists decreased the peak amplitude of Ca2+ current (ICa). The organic Ca2+-antagonists verapamil and diltiazem hastened the decay of ICa, while the inorganic Ca2+-antagonists Co2+ and Cd2+ delayed it. The difference in the action of the Ca2+-antagonists on the decay of ICa may result from the different effects of the agents on a voltage-dependent inactivation of the Ca2+ channel.
Y
Y
Oyama
N
N
Akaike
S
S
Kuraoka
K
K
Nishi
D000818:Animals; D002104:Cadmium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003035:Cobalt / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca / Q000502:physiology*; D009474:Neurons / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007473:Ion Channels; D002104:Cadmium; D003035:Cobalt; D014700:Verapamil; D004110:Diltiazem