Bluetongue virus-induced interferon in cattle.
Calves were inoculated IV with bluetongue virus (BTV), serotype 10. Titers of interferon (IFN) in serum and BTV in peripheral blood were determined. All inoculated calves produced circulating IFN that persisted for 2 to 4 days. Highest titers of BTV in peripheral blood were present after serum IFN was no longer detected. The persistence of BTV in peripheral blood, as compared with the transient IFN response, indicated that IFN was most important in the initial antiviral response of cattle to BTV infection. Bluetongue virus is probably not a suitable model inducer of circulating IFN in cattle because the profound neutropenia that accompanied BTV infection may predispose cattle to infections with other agents.
N J
NJ
MacLachlan
J
J
Thompson
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000032:analysis; D001819:Bluetongue / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D001820:Bluetongue virus / Q000276:immunology / Q000302:isolation & purification; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D007372:Interferons / Q000097:blood*; D007958:Leukocyte Count / Q000662:veterinary; D009500:Neutralization Tests; D012756:Sheep; D014766:Viremia / Q000382:microbiology
D000914:Antibodies, Viral; D000998:Antiviral Agents; D007372:Interferons