Synthesis of vinca alkaloids and related compounds, XLIV: Synthesis of trifluoro-apovincaminic acid ester.
Via the intermediate iminium salt 8 the 21,21,21-trifluoro-apovincaminic acid ethyl ester (2), a derivative of CAVINTONR (1) was synthesized. The pharmacological effect of 2 changed dramatically compared with the parent compound.
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
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Incze
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Sóti
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Kardos-Balogh
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Kajtár-Peredy
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Szántay
D055598:Chemical Phenomena; D002621:Chemistry; D014748:Vinca Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology
D014748:Vinca Alkaloids; C065619:ethyl 21,21,21-trifluoroapovincaminate