Human immunodeficiency virus type 1 reference materials.
Since licensure of the first human immunodeficiency virus type 1 screening assay in March 1985, there has been a need for well-characterized human immunodeficiency virus type 1 reference sera. These sera would be used in an effort to ensure uniformity of human immunodeficiency virus type 1 test results worldwide. Three major organizations--the World Health Organization, the Pan American Health Organization, and the National Committee for Clinical Laboratory Standards working with the College of American Pathologists--have ongoing programs aimed at the preparation of these reference sera. All three organizations are preparing both negative and human immunodeficiency virus type 1 seropositive sera. In addition, one organization is preparing early sero-converter and late acquired immunodeficiency syndrome samples. The status of these efforts and the serologic characteristics of the sera were reviewed.
Ortho Diagnostic Systems, Inc. Raritan, NJ 08869.
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O'Brien
D015492:AIDS Serodiagnosis / Q000592:standards*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007391:International Cooperation; D007753:Laboratories / Q000592:standards; D010175:Pan American Health Organization; D012015:Reference Standards; D012955:Societies, Medical; D014481:United States; D014944:World Health Organization