Causal prophylactic activity of a new 8-aminoquinoline derivative against Plasmodium cynomolgi B in rhesus monkeys.
A new 8-aminoquinoline derivative, N1-(3-acetyl-4-5-dihydro-2 furanyl)-N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine, synthesized at CDRI, Lucknow, showed causal prophylactic activity at 3.16 mg/kg x 3 doses (on day -1, 0 and +1) against sporozoite induced P. cynomolgi B infection in rhesus monkeys. Single dose of 10 mg/kg of this compound on day 0 also prevented establishment of patient infection. Activity of the compound was comparable to that of primaquine (with causal prophylactic activity at 1.78 mg/kg in three day test and at 10.0 mg/kg in single dose test).
Division of Microbiology, Central Drug Research Institute, Lucknow.
S K
SK
Puri
G P
GP
Dutta
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000517:prevention & control*; D011319:Primaquine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000962:Antimalarials; D011319:Primaquine; C063469:bulaquine