[Effects of T-activin on the morphology of the thymus gland in experimental injury of the lower limbs in mice (anti-stress effect of T-activin)].
The effect of T-activin on thymic involution under the experimental trauma of femur was studied. T-activin in a dose of 1.0 micrograms/mouse was injected into young male (CBA X C57BL)F1 mice weighing 17.5-19.0 g before (I injection) or immediately after the fracture of the femur during 3 days. Morphometric analysis of the thymus was made 1, 5, 10 and 15 days after the trauma. It was found that T-activin suppressed the involution of the thymus, induced by the trauma, during the first 5 days and accelerate the process of its regeneration. It is suggested, that T-activin displays protective anti-stress effect on the mouse thymic involution.
Koval'skaia
N I
NI
Arion
V N
VN
Blinkov
V N
VN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005264:Femoral Fractures; D007869:Leg Injuries; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D012038:Regeneration; D013312:Stress, Physiological / Q000517:prevention & control*; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Izuchenie vliianiia taktivina na morfologiiu timusa pri éksperimental'noĭ travme nizhneĭ konechnosti u mysheĭ (antistressornyĭ éffekt taktivina).