Studies of neurotransmitter chemistry of central nervous system neurons in primary tissue culture.
Primary tissue culture methods have been applied to various areas of the central nervous system, including cerebral cortex, spinal cord, cerebellum, hippocampus, hypothalamus, striatum, mesencephalon, lower brain stem and retina. Experimental studies in vitro involving central neurotransmission are discussed here. Information gleaned from such studies impacts on neurotransmitter identification, neuronal development, patterns of receptor distribution, peptidergic transmission, transmitter metabolism, synaptogenesis and the regulation of synaptic development.
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Thomas
D000109:Acetylcholine / Q000502:physiology; D000110:Acetylcholinesterase / Q000378:metabolism; D000200:Action Potentials; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D002794:Choline / Q000502:physiology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004594:Electrophysiology; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D008636:Mesencephalon / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009496:Neurotensin / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology; D011976:Receptors, Muscarinic / Q000378:metabolism; D012160:Retina / Q000502:physiology; D013004:Somatostatin / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology; D013373:Substance P / Q000502:physiology; D013569:Synapses / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology; D014667:Vasopressins / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018377:Neurotransmitter Agents; D011942:Receptors, Adrenergic, alpha; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; D014667:Vasopressins; D013373:Substance P; D007987:Gonadotropin-Releasing Hormone; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D009074:Melanocyte-Stimulating Hormones; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002794:Choline; D000109:Acetylcholine; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine