[The postoperative changes in the cellular immune response in vivo in patients with colorectal carcinoma after preoperative acute normovolemic hemodilution--a randomized, prospective and comparative study].
The in vivo changes in the cell-mediated immune response (CMIR) were studied in 40 patients undergone planned operation for colorectal cancer; delayed skin hypersensitivity test was used after intracutaneous application of standardized set of antigens produced at the Research Institute of Infectious and Parasitic Diseases in Sofia. The tests were performed, as follows: T0--2 days before the operation; T1--1 and T2--7 days after the operation. The tests were read after 48 hours, taking into consideration the sum of the mean diameters of the "positive" papules (in mm) and the number of antigens inducing positive skin response. Twenty patients received preoperative acute normovolemic hemodilution (PANHD)--group A, and the other 20--blood substitution by routine method--group B, control. Comparison of the results for T0 revealed no significant difference between the two groups. For T1 and T2 the mean sums of the mean diameters of positive papules in group B patients showed statistically significant decrease (p less than 0.001) both compared to T0 and to the respective values in group A patients. The following conclusions were made: 1. After PANHD the patients retained normal CMIR after operation: 2. Patients who received homologous blood substitution had statistically significant inhibition of CMIR on the 7. postoperative day.
Nikolov
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery; D005260:Female; D006438:Hemodilution; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D011446:Prospective Studies; D011897:Random Allocation; D012867:Skin / Q000276:immunology
Sledoperativni promeni na kletŭchniia imunen otgovor in vivo u bolni s kolorektalen kartsinom sled predoperativna ostra normovolemichna khemodilutsiia--randomizirano, prospektivno i sravnitelno prouchvane.