Antigen-specific T-cell lines transfer protective immunity against Trichinella spiralis in vivo.
T-cell lines specific for infective muscle larvae antigens of the intestinal nematode Trichinella spiralis have been generated in vitro. These antigen-specific T-cell lines express the L3T4+ Ly2- phenotype and secrete the lymphokines IL-2, IL-3 and gamma-IFN. They are stable in culture for up to 15 weeks and are protective when adoptively transferred into naive recipients. As few as 2 x 10(5) T. spiralis-specific tract. In addition, intestinal mastocytosis and peripheral blood eosinophilia were accelerated after adoptive transfer of T. spiralis-specific T-cell lines.
Riedlinger
J
J
Grencis
R K
RK
Wakelin
D
D
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D002460:Cell Line; D000939:Epitopes / Q000276:immunology*; D007116:Immunization, Passive; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
D000947:Antigens, Helminth; D000939:Epitopes