Central effects of an antagonist and an antiserum to substance P on serum gonadotropin and prolactin secretion.
The central effects of both an antagonist and an antiserum to substance P (SP) on gonadotropin and prolactin (Prl) secretion were studied in castrated male rats. The lateral ventricular injection (20 micrograms) of an analogue to SP possessing antagonistic properties resulted in significantly suppressed serum LH levels without altering serum FSH and Prl levels when compared with saline-injected control animals. Similarly, the lateral ventricular injection of an antiserum to SP also resulted in significantly suppressed LH levels when compared to control animals injected with normal rabbit serum. Additionally, no changes were observed in the levels of serum FSH and Prl as a result of the anti-SP injection. Thus, although indirect, these results support the hypothesis that SP may have a central stimulatory action on LH secretion, but not FSH and Prl secretion.
Dees
W L
WL
Skelley
C W
CW
Kozlowski
G P
GP
D000818:Animals; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007106:Immune Sera / Q000276:immunology; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*
D007106:Immune Sera; D013373:Substance P; C038073:substance P, Arg(1)-Pro(2)-Trp(7),(9)-LeuNH(2)(11)-; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone