[Effect of heparin and fepromaron on the kallikrein-kinin system in pituitrin-induced hypertension].
A study was made of the effects of heparin and sodium fepromaron on prekallikrein (PK); kallikrein inhibitors (KI), initial esterase activity (IEA) of rat blood in health and pituitrin hypertension. Pituitrin hypertension was associated with IEA increase and KI decrease. A single administration of heparin raised IEA; if administered for 3 days, heparin reduced IEA. After pituitrin administration heparin decreased IEA if administered once or for 3 days. Administration of fepromaron in courses following pituitrin also reduced. IEA, with that reduction being preserved for not less than 4 days after drug discontinuation. Similarity of the effects of heparin and fepromaron on hemocoagulation and the tone of blood vessels suggests the common mechanisms of their action on the blood kinin system.
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Semenchenko
D015110:4-Hydroxycoumarins / Q000627:therapeutic use*; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D010909:Pituitary Hormones, Posterior / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D007705:Kinins; D010909:Pituitary Hormones, Posterior; C004791:phepromaron; D006493:Heparin; D007610:Kallikreins
Vliianie geparina i fepromarona na kallikrein-kininovuiu sistemu pri pituitrinovoĭ gipertenzii.