Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen.
We isolated 16 new monoclonal antibodies that recognize large T antigen of simian virus 40 and mapped the epitopes to three distinct regions of the large T antigen. Also, 3 of the 16 recognized the large T antigen of the human papovavirus BKV.
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Gurney
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Tamowski
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000032:analysis / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D009856:Oncogene Proteins, Viral / Q000032:analysis / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology; D027382:Polyomaviridae; D011489:Protein Denaturation
D000911:Antibodies, Monoclonal; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D000939:Epitopes; D007074:Immunoglobulin G; D009856:Oncogene Proteins, Viral