[Expression of proliferation-associated antigens in cutaneous lymphoid infiltrates].
The expressions of PC (Ki-67), DNA polymerase-alpha and OKT9 (transferrin receptor) were studied in 29 cutaneous T cell lymphomas and in a variety of benign cutaneous lymphoid infiltrates by immunohistochemistry using monoclonal antibodies. PC, DNA polymerase-alpha and OKT9 were detected in malignant cutaneous lymphoid infiltrates much more frequently than in benign cutaneous infiltrates. Besides, correlation with histologic grading of lymphomas and expressions of those antigens on lymphoid cells was indicated: the high-grade types, e.g. immunoblastic type, exhibited greater positivity than intermediate-grade types and much more than low-grade types.
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Department of Dermatology, Yokohama City University School of Medicine.
D000954:Antigens, Surface / Q000378:metabolism*; D004257:DNA Polymerase II / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008223:Lymphoma / Q000276:immunology / Q000473:pathology; D011990:Receptors, Transferrin / Q000378:metabolism; D012867:Skin / Q000276:immunology* / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology
D000954:Antigens, Surface; D019394:Ki-67 Antigen; D011990:Receptors, Transferrin; D004257:DNA Polymerase II