Production of paralytic shellfish toxins by a bacterium Moraxella sp. isolated from Protogonyaulax tamarensis.
A bacterium Moraxella sp. isolated from Protogonyaulax tamarensis was cultured in various conditions. Changes of toxicity and toxin components of the cells during culture were analyzed by bioassay and HPLC-fluorometric analysis. Toxin productivity of Moraxella sp. increased when it was cultured in nutrition-deficient environments. The main toxins produced by Moraxella sp. in these conditions were gonyautoxins (GTXs), mainly GTX 1 and 4 which are major toxins of P. tamarensis.
Kodama
M
M
Laboratory of Marine Biological Chemistry, School of Fisheries Sciences, Kitasato University, Iwate, Japan.
Ogata
T
T
Sakamoto
S
S
Sato
S
S
Honda
T
T
Miwatani
T
T
D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003470:Culture Media; D004141:Dinoflagellida / Q000382:microbiology*; D008387:Marine Toxins / Q000096:biosynthesis*; D009016:Moraxella / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D010243:Paralysis / Q000139:chemically induced*; D012530:Saxitoxin / Q000031:analogs & derivatives* / Q000096:biosynthesis
D001427:Bacterial Toxins; D003470:Culture Media; D008387:Marine Toxins; D012530:Saxitoxin; C013007:gonyautoxins