The role of cytokines in the development of osteoarthritis.
A range of cytokines have been suggested as intermediaries which may have effects on cellular metabolism and proliferation. Interleukin 1 has been most intensively studied and has multiple biological activities, however other polypeptides may also have significant effects on cartilage. A greater understanding of the biochemical mechanisms involved in the development and progression of osteoarthritis (OA) may lead to a rational approach to therapeutic management.
Loyau
G
G
Laboratory of Biochemistry, University of Caen, France.
Pujol
J P
JP
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001685:Biological Factors / Q000378:metabolism / Q000502:physiology*; D002358:Cartilage, Articular / Q000378:metabolism*; D016207:Cytokines; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism / Q000502:physiology; D010003:Osteoarthritis / Q000188:drug therapy / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D001685:Biological Factors; D016207:Cytokines; D007375:Interleukin-1