Selective facilitation of putative corticotropin-releasing factor-secreting neurones by interleukin-1.
The activity of single hypothalamic paraventricular nucleus (PVN) neurones was recorded in order to examine the mechanism by which the endogenous pyrogen interleukin-1 (IL-1) increases activity of the hypothalamo-hypophyseal-adrenocortical axis. IL-1 injected intravenously caused a rapid increase in the electrical activity of putative corticotropin-releasing factor (CRF)-secreting neurones located within the PVN. The activity of neighboring, electrophysiologically identified, vasopressin-secreting neurones was not altered by the stimulus, indicating a lack of involvement of this secretagogue of adrenocorticotropic hormone (ACTH) in this response to IL-1. These results support the concept of a rapid and specific activating effect of IL-1 upon hypothalamic CRF secretion as a part of a bidirectional communicating link between immune and central nervous systems.
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
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Saphier
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Ovadia
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D004594:Electrophysiology; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D007375:Interleukin-1; D003346:Corticotropin-Releasing Hormone