[Proliferating patterns of basal cell carcinoma--immunohistological study by means of anti-BrdU monoclonal antibody].
The proliferating patterns of basal cell carcinoma were investigated by means of BrdU (bromodeoxyuridine), which is analogue of thymidine and by means of anti-BrdU monoclonal antibody. We classified 8 cases of basal cell carcinoma into three groups; 1) 21 nests of solid type basal cell carcinoma without retraction space 2) 6 nests of solid type basal cell carcinoma with retraction space 3) 5 nests of superficial type basal cell carcinoma without retraction space. The labeling index was obtained in each area of the outermost cells and inner cells in each nest of the three groups. The results indicated that when there was no retraction space, the labeling index of the outermost cells was high, and when there was some retraction space, the labeling index of the outermost cells was low. In other words, the proliferation of basal cell carcinoma cells occurs in the outermost cells of a nest. When there was retraction space, the role of the outermost cells of a nest diminished or disappeared.
Department of Dermatology, Kumamoto University Medical School.
K
K
Yoshimura
K
K
Egawa
T
T
Ono
D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001973:Bromodeoxyuridine / Q000276:immunology*; D002280:Basal Cell Carcinoma / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D001973:Bromodeoxyuridine