[Erythroid colonies derived from BFU-E from the bone marrow in a patient with type I congenital dyserythropoietic anemia].
The findings of in vitro culture of bone-marrow BFU-E from a patient with type I dyserythropoietic anaemia are reported, scarce data being seemingly available in the literature. The number of BFU-E in the culture was increased four-fold with respect to the normal values. The morphologic study of the colonies showed in all cases varying number of erythroblasts with internuclear bridges (5-20%). Upon ultrastructural examination of the colonies, a great number of erythroblasts exhibited morphologic alterations, spongy chromatin and internuclear bridges being commonest. These findings suggest that an alteration of the progenitor erythroid cells exists in type I dyserythropoietic anaemia, whereas the morphological defects appreciated show great variation in the progeny of each BFU-E.
Unitat d'Hematologia i Oncologia, Hospital de la Creu Roja, Barcelona.
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L
Florensa
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S
Woessner
J
J
Almarcha
P
P
Pardo Peret
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R
Lafuente
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RM
Vilá
D000328:Adult; D000742:Anemia, Dyserythropoietic, Congenital / Q000473:pathology*; D000745:Anemia, Hemolytic, Congenital / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D002478:Cells, Cultured; D015672:Erythroid Precursor Cells / Q000473:pathology*; D006801:Humans; D008297:Male
Estudio de colonias eritroides derivadas de BFU-E de medula ósea en un paciente con anemia diseritropoyética congénita tipo I.