Bulbospinal substance P and sympathetic regulation of the cardiovascular system: a review.
The neurotransmitter role of substance P in mediating sympathoexcitatory effects in the spinal cord and cardiovascular effects elicited from the ventral medulla is presented. SP neurons located in the ventral medulla project to the intermediolateral cell column (IML) of the thoracic spinal cord. Intrathecal administration of a SP analog excites sympathetic outflow to the cardiovascular system. Likewise, activation of the ventral medulla results in sympathetically mediated increases in blood pressure and heart rate which are blocked with SP antagonists. The IML contained a high density of SP binding sites through which the peptide likely exerts its sympathoexcitatory influence on the cardiovascular system.
Helke
C J
CJ
Charlton
C G
CG
Keeler
J R
JR
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology; D001640:Bicuculline / Q000494:pharmacology; D001931:Brain Mapping; D002320:Cardiovascular Physiological Phenomena; D002415:Cats; D004525:Efferent Pathways / Q000502:physiology; D006973:Hypertension / Q000209:etiology; D007278:Injections, Spinal; D008526:Medulla Oblongata / Q000502:physiology*; D010446:Peptide Fragments; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011918:Rats, Inbred SHR; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013116:Spinal Cord / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D010446:Peptide Fragments; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P; D005680:gamma-Aminobutyric Acid; C032720:substance P (5-11), pGlu(5)-MePhe(8)-MeGly(9)-; D011761:Pyrrolidonecarboxylic Acid; D001640:Bicuculline