[The Shine-Dalgarno sequence and the effectiveness of translation initiation].
On the basis of theoretical analysis of different mRNAs secondary structure it is suggested that the efficiency of procaryotic translation initiation depends to a great extent on the possibility to generate a single-stranded region around the initiation codon. The local disruption of the mRNA secondary structure is mostly determined by interaction according to Shine--Dalgarno of 16S rRNA with the complementary mRNA region. Other mechanisms of single-stranded region generation in the initiation zone of mRNA are discussed.
Khudiakov
Iu E
IuE
D001483:Base Sequence; D003062:Codon; D004926:Escherichia coli / Q000235:genetics; D005796:Genes; D008957:Models, Genetic; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009876:Operon; D010442:Peptide Chain Initiation, Translational; D010957:Plasmids; D012329:RNA, Bacterial / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012706:Serratia marcescens / Q000235:genetics
D003062:Codon; D012329:RNA, Bacterial; D012333:RNA, Messenger
Posledovatel'nost' Shaĭna-Dal'garno i éffektivnost' initsiatsii transliatsii.