[The action of timoptin peptides on the hemostatic system].
Repeated introduction of thymus polypeptide drug thymoptine (8 times every 24 hours, 1 microgram/kg) led to the increase in total and non-enzymatic fibrinolytic activity of blood plasma and the decrease in fibrinogen concentration. Thymoptine could lyse non-stabilized fibrin and cause depolymerization of aggregates of fibrin monomer in virto. Highest depolymerization activity was observed at thymoptine concentration of 10 micrograms/ml.
Liapina
L A
LA
Pastorova
V E
VE
Kudriashov
B A
BA
Zazhireĭ
V D
VD
Sokolova
E A
EA
Livshits
V A
VA
Ashmarin
I P
IP
D000818:Animals; D001780:Blood Coagulation Tests; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013947:Thymosin / Q000031:analogs & derivatives*; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland
D010455:Peptides; D013949:Thymus Extracts; C065652:timoptin; D013947:Thymosin
Deĭstvie peptidov timoptina na sistemu gemostaza.