Platelet 5-HT uptake in post-stroke depression.
Serotonin (5-HT) uptake into platelets is reduced in functionally depressed patients. Depression following stroke (cerebrovascular accident; CVA) is common and severe. Sixteen patients who had suffered a CVA within 6 to 12 months and who were medication-free had blood taken for measurement of platelet 5-HT uptake. Seven of these patients were depressed. These were compared with age- and sex-matched hospital controls. No difference in platelet 5-HT uptake was found across these groups.
Department of Psychiatry, Trinity College Medical School, St. James's Hospital, Dublin, Ireland.
S
S
Barry
O M
OM
Phillips
D C
DC
Williams
T G
TG
Dinan
D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D002544:Cerebral Infarction / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000097:blood* / Q000175:diagnosis; D012701:Serotonin / Q000097:blood*
D012701:Serotonin