[Determination of antibodies to Streptococcus group A polysaccharide by an immunodiffusion method in human sera in various pathological processes of streptococcal etiology].
A method for the assay of antibodies to the specific antigenic determinant of group A streptococcal polysaccharide (A-polysaccharide) in human sera was developed. The sera were tested in the precipitation test in agar gel with different doses of A-polysaccharide. The presence of a high level of the above-mentioned antibodies is indicative of infection caused by group A streptococcus, but not streptococci of other groups or by the L-forms of streptococci. In 87.5% of patients with primary rheumatism a high level of antibodies to the specific antigenic determinant of A-polysaccharide was detected during the first day of the disease, which confirms most convincingly the etiological role of group A streptococcus in rheumatism. Considerable differences in the level of antibodies to A-polysaccharide in the active and non-active phases of rheumatism have been established, which makes it possible to use the presence of a high level of these antibodies as an indicator of the rheumatic process activity. A considerable percentage of sera with a high level of antibodies to A-polysaccharide was also detected in erysipelas and acute glomerulonephritis patients.
Borodiiuk
N A
NA
Liampert
I M
IM
Mikhaĭlova
I N
IN
Novikov
F E
FE
Cherkasov
V L
VL
D000907:Antibodies, Bacterial / Q000032:analysis*; D000939:Epitopes / Q000032:analysis; D004886:Erysipelas / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012008:Recurrence; D012216:Rheumatic Diseases / Q000276:immunology; D013290:Streptococcal Infections / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*
D000907:Antibodies, Bacterial; D000939:Epitopes; D011135:Polysaccharides, Bacterial
Opredelenie antitel k polisakharidu streptokokka gruppy A metodom immunodiffuzii v syvorotkakh cheloveka pri razlichnykh patologicheskikh protsessakh streptokokkovoĭ étiologii.