Sobrerol enantiomers and racemates: solid-state spectroscopy, thermal behavior, and phase diagrams.
The characterization of the solid state of sobrerol enantiomers and racemates has been accomplished by a number of techniques on solid phase such as thermal analysis (DSC) and spectroscopy (IR, 13C NMR, and X-ray diffraction both on powders and on single crystal). Experimental and theoretical binary phase diagrams of cis- and trans-sobrerol enantiomers and their mixtures have been drawn and are discussed. Thermal analysis allowed, moreover, the detection of cis racemate polymorphism. Finally, the quantitative analysis of the cis racemate as an impurity of the trans racemate by means of microcalorimetric determinations is reported.
Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Italy.
G
G
Bettinetti
F
F
Giordano
G
G
Fronza
A
A
Italia
R
R
Pellegata
M
M
Villa
P
P
Ventura
D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D013729:Terpenes / Q000032:analysis*; D014961:X-Ray Diffraction
D013729:Terpenes; C003316:sobrerol