[Action of interferons on the reproduction of herpes simplex viruses in in vitro experiments].
Tests of various interferon preparations (alpha, alpha2, alpha-beta, beta, and swine leukocyte) in human diploid fibroblast culture for the presence or absence of cytopathic effect of herpes simplex viruses type 1 and 2 (HSV-1 and HSV-2) demonstrated antiviral effect of all interferons with the exception of lymphoblastoid one. Preparations of alpha and swine leukocyte interferons were the most effective for inhibition of HSV-1 reproduction. Recombinant interferon was 10-fold and fibroblast interferon 100-fold less active for HSV-1 than alpha- and swine leukocyte interferons. All the interferons under study (alpha-beta) were similarly active in their antiviral effect on HSV-2 reproduction.
Pokidysheva
L N
LN
Temicheva
E V
EV
D000818:Animals; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011994:Recombinant Proteins / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*; D013552:Swine; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D011994:Recombinant Proteins; D007372:Interferons
Deĭstvie interferonov na reproduktsiiu virusov prostogo gerpesa v opytakh in vitro.