Age-related changes in mitogen-induced lymphocyte proliferation and polymorphonuclear neutrophil function in the piglet.
Changes in concentration of plasma cortisol, mitogen-induced lymphocyte proliferation and the phagocytic and killing abilities of polymorphonuclear neutrophils (PMN) were assessed in 24 crossbred piglets at .5, 1, 3 and 6 wk of age. Concentrations of blood cortisol were high at birth but decreased (P less than .001) thereafter. Spontaneous lymphocyte proliferation was approximately 10-fold higher in the newborn than in pigs 6 wk old. The methods by which data on lymphocyte proliferation were expressed greatly influenced the results of the age-related changes in lymphocyte response. When lymphocyte proliferation was expressed as a stimulation index, there was an increase in mitogen-induced lymphocyte proliferation with advancing age. However, when lymphocyte proliferation was expressed as total counts per minute, mitogen-induced lymphocyte proliferation decreased with increasing age. In general, no significant age-related changes were observed in PMN function except for a transient decrease in PMN phagocytic ability at wk 3. Piglets were born with high concentrations of blood cortisol; this was associated with age-related changes in lymphocyte proliferation.
Washington State University, Pullman 99164-6320.
C D
CD
Hoskinson
B P
BP
Chew
T S
TS
Wong
D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008934:Mitogens; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D013552:Swine / Q000276:immunology*
D008934:Mitogens; D006854:Hydrocortisone