[Clinical and experimental study of wei-nin granules in the treatment of chronic superficial gastritis].
408 cases of chronic superficial gastritis diagnosed by fibergastroscopy and histology were treated with Wei-Nin granules (WNG), The symptomatic effective rate was 90.5%, while therapeutic effect proved by gastroscopy and histology was 81.9% and 72.8% respectively. These results compared with the control were statistically significant. In animal experiment, it is shown that WNG had an evident protective effect to the mucous membrane of rats and guinea pigs. These animals had suffered gastritis and gastric ulcer induced by drugs. The effect of WNG was similar to cimetidin. The pharmaceutical mechanism of WNG proved that it could inhibit the secretion of pepsin. The acute and chronic poisoning test was negative both in vitro and in vivo. WNG were nearly no any side effects in this study. Therefore it is a new type of herbs in treatment of chronic superficial gastritis and is different from H2-receptor inhibitor.
Beijing Jishuitan Hospital.
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D000328:Adult; D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005756:Gastritis / Q000188:drug therapy*; D005773:Gastroscopy; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D016037:Single-Blind Method; D013276:Stomach Ulcer / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D002927:Cimetidine