Histamine and human heart.
Heart fragments obtained from human right atrium contain 1.5 +/- 0.2 micrograms of histamine per gram of wet tissue. Human heart spontaneously synthesizes significant amounts of PGI2, PGF2 alpha, PGE2 and TxA2. The Ca2+ ionophore A 23187 (0.5-3 micrograms/ml) dose-dependently induces histamine release and prostanoid production. Histamine (0.5-1 micrograms/kg/min) infusion in 10 normal donors produced an increase in heart rate and a significant depression of the ST segment. Selective H1 receptor stimulation in patients undergoing cardiac catheterization resulted in a decrease of the mean aortic pressure and of coronary vascular resistance.
M
M
Triggiani
A
A
Genovese
C
C
Vigorito
G
G
Marone
D001491:Basophils / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008407:Mast Cells / Q000502:physiology; D009206:Myocardium / Q000166:cytology*; D013205:Staphylococcal Protein A / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D013205:Staphylococcal Protein A; D000001:Calcimycin; D006632:Histamine