A correlation of induced mixed-function oxidase specific activity to C-H bond strengths in partially chlorinated monocyclic hydrocarbons.
The nature of structure-function relationships between the mixed-function oxidase (MFO) system and certain chemically related xenobiotics has been studied. The total hepatic induction index has been modified and used to investigate whether the induction of hepatic MFO is primarily a response to molecular shape (entropic) or to the strength of specific carbon-hydrogen bond strength (enthalpic). Using both Sprague-Dawley male rats and ring doves (Streptopelia risoria) and testing with benzene, 1,2,4-trichlorobenzene, cyclohexane and gamma-1,2,3,4,5,6-hexachlorocyclohexane as both inducers and substrates, a response of the MFO system to substrate C-H bond strength has been found.
L J
LJ
Brownlee
B R
BR
Hollebone
D000818:Animals; D001554:Benzene / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002722:Chlorobenzenes / Q000494:pharmacology; D010856:Columbidae; D003510:Cyclohexanes / Q000494:pharmacology; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D001556:Hexachlorocyclohexane / Q000494:pharmacology; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009249:NADP / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D002722:Chlorobenzenes; D003510:Cyclohexanes; D006843:Hydrocarbons, Chlorinated; C036720:trichlorobenzene; D009249:NADP; D001556:Hexachlorocyclohexane; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1; D001554:Benzene