Neutralization of interferon produced early during rabies virus infection in mice.
Inoculation of mice (strain C3H/He) with a purified preparation of fixed rabies virus led to the production of interferon with two different peaks of activity detectable in the plasma: an early peak 24 h after inoculation followed by another peak on the 7th day after infection. The level of splenic 2-5A synthetase was enhanced in parallel with the pattern of interferon activity. Neutralization of the first peak of interferon activity by anti-mouse alpha/beta interferon globulin blocked the induction of splenic 2-5A synthetase and modified the development of disease. Infected mice given anti-interferon globulin had a significantly shorter morbidity period than normally infected mice. These results suggest that interferon produced early after virus inoculation plays a role in the onset of rabies disease.
R
R
Marcovistz
J
J
Galabru
H
H
Tsiang
A G
AG
Hovanessian
D000818:Animals; D000936:Antigen-Antibody Complex; D002460:Cell Line; D006224:Cricetinae; D007074:Immunoglobulin G / Q000276:immunology; D007372:Interferons / Q000096:biosynthesis* / Q000276:immunology; D007668:Kidney; D051379:Mice; D008809:Mice, Inbred C3H; D011818:Rabies / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007372:Interferons