Longitudinal response of pulmonary function to bronchodilators in cystic fibrosis.
Previous studies have found that between 0 and 95% of patients with cystic fibrosis (CF) have a significant response to bronchodilators. These studies have been limited by small numbers and the measurement of response at one point in time. We analyzed the response to bronchodilators of patients with CF in a longitudinal and cross-sectional manner using pulmonary function data from 1980 to 1988. Overall, the proportion of patients with a positive response to bronchodilators was relatively large but not consistent over time. Of 573 tests in 127 persons, a positive response occurred in 68 tests of 51 patients. A negative response occurred in 19 tests of 17 patients. Only nine patients had a positive response in more than one third of their tests. The cross-sectional analysis showed variability similar to previous cross-sectional studies. Although a large proportion of patients with CF had a response to bronchodilators, the response was not consistent and may have been related to the number of tests performed. Continued longitudinal testing is necessary for valid decisions for bronchodilator use and for documenting the length, variability, and clinical significance of these responses.
Department of Pediatrics and Epidemiology, University of Pittsburgh, School of Public Health, Pennsylvania.
E N
EN
Pattishall
D000336:Aerosols; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005260:Female; D005540:Forced Expiratory Flow Rates / Q000187:drug effects; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007528:Isoetharine / Q000008:administration & dosage / Q000627:therapeutic use; D007545:Isoproterenol / Q000008:administration & dosage / Q000627:therapeutic use; D008137:Longitudinal Studies; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D014797:Vital Capacity / Q000187:drug effects
D000336:Aerosols; D001993:Bronchodilator Agents; D007545:Isoproterenol; D007528:Isoetharine