[Donor selection for the production of factor XIII preparations].
For the purpose of establishing a programme of plasmapheresis for manufacturing preparations containing factor VIII, investigations were made to check the expediency of selecting donors. Factor VIII activity (Factor VIII: C) was determined in a total of 165 donors of plasmapheresis. Dependencies of factor-VIII: C on blood group, age and influence of smoking were examined. Depending on the blood group (0 less than A, B, AB) the results found by us showed significant differences in factor-VIII: C. The results are discussed and compared with data in literature. A selection of donors is considered to be reasonable. Increases in gaining factor-VIII are possible by making a pre-selection according to blood groups or better by exact testing respectively.
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D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001782:Blood Donors; D001789:Blood Group Antigens; D001798:Blood Proteins / Q000032:analysis; D005169:Factor VIII / Q000032:analysis / Q000302:isolation & purification*; D006452:Hemoglobinometry; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D012907:Smoking
D001789:Blood Group Antigens; D001798:Blood Proteins; D005169:Factor VIII
Untersuchungen zur Spenderselektion für die Herstellung von Faktor-VIII-Präparaten.