[Effect of a new anti-inflammatory agent chlotazol on nucleic acid metabolism in rat liver cells].
Effects of a new antiinflammatory preparation chlotozol on the activity of enzymes participating in metabolism of nucleic acids, on rates of DNA and RNA synthesis and on the transport of RNA from nuclei into cytoplasm were studied in liver cells of Wistar rats. Administration of chlotozol did not distinctly affect the rate of DNA synthesis, the RNAase activity, the rate of RNA transport from nuclei into cytoplasm. Chlotozol caused a decrease of the RNA polymerase activity in nuclei in vitro. Thus, chlotozol did not exhibit negative effects on reduplication and transport of RNA from nuclei into cytoplasm in liver cells of intact animals. Inhibitory effect of chlotozol on the RNA-polymerase activity appears to be one of mechanisms responsible for regulation of transcription.
Shereshevskaia
Ts M
TsM
Bozhkov
A I
AI
Skliar
A I
AI
Shakhbazov
V G
VG
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002697:Chloral Hydrate / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D002697:Chloral Hydrate; D012313:RNA; C034140:chlotazol; D004247:DNA; D012321:DNA-Directed RNA Polymerases
Vliianie novogo protivovospalitel'nogo preparata khlotazola na nukleinovyĭ obmen v kletkakh pecheni krys]