Relationship between butirosin biosynthesis and sporulation in Bacillus circulans.
The relationship between butirosin biosynthesis and certain biochemical characteristics related to sporulation in a strain of Bacillus circulans NRRL B-3313 was examined. The cellular content of dipicolinic acid increased while the amount of poly-beta-hydroxybutyrate decreased with changes in antibiotic productivity. Oligosporogenous mutants failed to synthesize the antibiotic and to degrade poly-beta-hydroxybutyrate. These observations suggest that spore formation may be related to antibiotic production in this strain of B. circulans.
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001407:Bacillus / Q000378:metabolism* / Q000502:physiology; D002076:Butirosin Sulfate / Q000096:biosynthesis*; D003470:Culture Media; D005285:Fermentation; D013171:Spores, Bacterial
D000900:Anti-Bacterial Agents; D003470:Culture Media; D002076:Butirosin Sulfate