[A case of congenital insensitivity to pain with destructive arthropathies of the limbs and spine. Discussion on nosology and physiopathology of the disease].
A seventeen year old boy presented with destructive arthropathy of the lower limbs and discovertebral spaces. Past history yielded recurrent episodes of indolent fractures and progressive knee and ankle deterioration. The patient denied any pain sensation in the past and at examination. Other neurological tests were normal. Beta-endorphin level was elevated in the CSF. Response to the cold pressor test was modified after injection of Naloxone. The nosology and physiopathology of congenital insensitivity to pain are discussed.
J M
JM
Le Parc
V
V
Brunod
J B
JB
Paolaggi
L
L
Auquier
D000293:Adolescent; D005121:Extremities / Q000000981:diagnostic imaging; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D000699:Pain Insensitivity, Congenital / Q000145:classification / Q000150:complications* / Q000503:physiopathology; D011859:Radiography
Etude d'un cas d'insensibilité congénitale à la douleur avec arthropathies destructrices des membres et du rachis. Discussion à ce propos de la nosologie et de la physiopathologie de l'affection.