Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release.
Quantitative modeling indicates that, in presynaptic terminals, the intracellular calcium concentration profile during inward calcium current is characterized by discrete peaks of calcium immediately adjacent to the calcium channels. This restriction of intracellular calcium concentration suggests a remarkably well specified intracellular architecture such that calcium, as a second messenger, may regulate particular intracellular domains with a great degree of specificity.
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Simon
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Llinás
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D049832:Decapodiformes; D004058:Diffusion; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials; D008954:Models, Biological; D012984:Software; D013569:Synapses / Q000502:physiology*
D007473:Ion Channels; D002118:Calcium