Interactions between melatonin and prolactin during gestation in mink (Mustela vison).
Immature female mink, 8 weeks of age in July, were treated with implants releasing melatonin. Mating, which induced ovulation, took place during the normal breeding season in the following March. Circulating prolactin and progesterone concentrations did not undergo the expected gestational increases, and no embryos implanted. A similar absence of gestational changes in prolactin and progesterone values ensued in primiparous mink treated with the melatonin implant 2-3 days after the second of 2 matings. Administration of exogenous sheep prolactin (0.5 mg/day) by minipump induced precocious elevation of progesterone concentrations in mated mink. Prolactin administration overcame the effects of melatonin, in that the corpora lutea were activated and embryos implanted, but exogenous prolactin resulted in degeneration of implanted embryos both in the presence and absence of chronic melatonin. The results suggest that melatonin has a single effect in alteration of gestation in mink; i.e. the prevention of prolactin secretion. Hyperprolactinaemia may inhibit embryo development in this species.
Murphy
B D
BD
Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Canada.
DiGregorio
G B
GB
Douglas
D A
DA
González-Reyna
A
A
D000818:Animals; D004343:Drug Implants; D004347:Drug Interactions; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology; D008907:Mink / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D004343:Drug Implants; D011374:Progesterone; D011388:Prolactin; D008550:Melatonin