Superior hemodynamics in left heart bypass without systemic heparinization.
Open-chest left heart bypass was performed in 10 canine experiments (30 +/- 9 kg) by a servo controlled roller pump for 6 h at a pump flow of 50 ml/min per kg bodyweight. The surfaces of the tubing sets were either standard (with systemic heparinization) or with end-point attached heparin (no systemic heparin). Besides continuous monitoring of hemodynamics, a standard battery of blood samples was taken before bypass, after 10 min and every hour thereafter. There is no evidence of increased fibrin production in the group with end-point attached heparin surfaces perfused without systemic heparinization. Superior hemodynamics in left heart bypass performed without systemic heparinization appear to be due to improved hemostasis, reduced blood loss and therefore reduced transfusion requirements. Left heart bypass with heparin-coated equipment has been successfully used for resection of a thoracoabdominal aneurysm in six patients.
Department of Surgery, University Hospital, Zurich, Switzerland.
L K
LK
von Segesser
B M
BM
Weiss
A
A
Gallino
B
B
Leskosek
F
F
Redha
A
A
von Felten
M
M
Turina
D000818:Animals; D001792:Blood Platelets / Q000032:analysis; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D004285:Dogs; D005337:Fibrin / Q000032:analysis; D006339:Heart Rate; D006400:Hematocrit; D006439:Hemodynamics; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D014914:Whole Blood Coagulation Time
D005337:Fibrin; D006493:Heparin