Trisomy 13 and myelodysplastic syndrome.
The clinical and cytogenetic data of a patient with myelodysplastic syndrome-refractory anemia with excess blasts (MDS-RAEB) and trisomy 13 as the sole abnormality are presented. This appears to be only the second report of such a patient. The presence of trisomy 13 is confirmed by in situ hybridization using an alphoid repeat probe L1.26, which is specific for the centromeres of both chromosomes 13 and 21.
Beverstock
G C
GC
Department of Human Genetics, State University Hospital, Leiden, The Netherlands.
Ploem
J E
JE
Wessels
H
H
van de Keur
D
D
Mollevanger
P
P
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014314:Trisomy