Induction of interferon in mice by sodium salt of 9-oxo-10-acridineacetic acid: specific enhancement by analogs.
9-oxo-10-acridineacetic acid bearing the common name of 10-carboxymethyl-9-acridanone or CMA (6) was found to be a very potent interferon (IFN) inducer in adult Balb/c mice. Seven structural analogs of CMA were synthetized and assayed for the interferon inducing ability. Three of the compounds had new chemical structures. The analogs were shown to be either weak or inactive interferon inducers. However, some of the analogs administered intraperitoneally (i.p.) or orally (p.o.) either 2 h before CMA or together with the active inducer enhanced by 10 to 60-fold the serum interferon response. We suggest that CMA induces interferon indirectly via a specific protein receptor. The specific enhancement of the serum interferon response to CMA by its inactive analogs may be explained in terms of the competition of the compounds for binding sites at the acceptor or transporting protein molecules. In the presence of an analog of CMA greater amount of free CMA may be available for the receptors in the target cells than when CMA acts alone. Only CMA bound to the receptor would be biologically active whereas the complexes of the compounds with the acceptor are biologically inert.
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Inglot
J
J
Młochowski
Z
Z
Szulc
O
O
Inglot
M
M
Albin
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007369:Interferon Inducers / Q000138:chemical synthesis*; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000166:Acridines; D007369:Interferon Inducers; D007372:Interferons; C026430:10-carboxymethyl-9-acridanone