[Alveolar proteinosis. Prolonged favorable course after total pulmonary lavage].
We report the outcome in a case of alveolar proteinosis diagnosed histologically in a 43 year old female. The increase in dyspnoea and the deterioration in the pulmonary function tests have lead to the realisation that a total pulmonary lavage was required under general anaesthesia. This was performed in two stages. A biochemical analysis of the lavage liquid showed an accumulation of phospholipids, proteins, and LDH. A subjective improvement was obtained in a few weeks followed by a slow radiological improvement as well as on CT scanning, and in respiratory function. Radiological and blood gas improvement was noted 19 months after total bilateral pulmonary lavage. Broncho-alveolar lavage is thus able to induce long-term improvement in pulmonary alveolar proteinosis.
Ecochard
D
D
Service de Pneumologie, Hôpital Louis-Pradel, Lyon.
Mornex
J F
JF
Caillet
J B
JB
Guidollet
J
J
Wiesendanger
T
T
Revel
D
D
Trillet
V
V
Cordier
J F
JF
Brune
J
J
D000328:Adult; D001784:Blood Gas Analysis; D001992:Bronchoalveolar Lavage Fluid / Q000032:analysis; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008279:Magnetic Resonance Imaging; D010743:Phospholipids / Q000032:analysis; D011506:Proteins / Q000032:analysis; D011649:Pulmonary Alveolar Proteinosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012129:Respiratory Function Tests; D007507:Therapeutic Irrigation; D014057:Tomography, X-Ray Computed
D010743:Phospholipids; D011506:Proteins; D007770:L-Lactate Dehydrogenase
Protéinose alvéolaire. Evolution favorable prolongée après lavage pulmonaire total.