Arterial blood pressure response in conscious rabbits to administration of C-terminal fragment of substance P into the cerebral ventricles, intravenously and intragastrically.
The blood pressure was measured in the common carotid artery in a cutaneous bridge in conscious rabbits. The synthetic hexapeptide SP6-11 of C-terminal fragment of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (Substance P) was administered to animals accustomed to the experimental environment in three separate trials: into the cerebral ventricles, intravenously and intragastrically. Introduction of 2 nmol/kg hexapeptide into the cerebral ventricles via a chronically implanted cannula in the lateral ventricle caused an increase in the blood pressure, reaching a peak 10 min after administration. This maximum increase averaged 34.5 mmHg. Intravenous injection of 2 nmol/kg caused after 1 min a rapid fall in the blood pressure, the decrease averaging 42.7 mmHg at this time. Administration of 2 mg/kg into the stomach caused a slight decrease in blood pressure. Although the decrease was only slight it was statistically significant after 10 min.
B
B
Meltzer
W Z
WZ
Traczyk
J
J
Kubicki
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D007267:Injections; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D010446:Peptide Fragments / Q000008:administration & dosage*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D011817:Rabbits; D013270:Stomach; D013373:Substance P / Q000008:administration & dosage*
D000700:Analgesics; D010446:Peptide Fragments; D013373:Substance P; C032292:substance P (6-11); D011761:Pyrrolidonecarboxylic Acid