The lymphatic route. VII. Distribution of recombinant human interleukin-2 in rabbit plasma and lymph.
Human recombinant (R) interleukin-2 (IL-2) has been administered through intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) routes and its distribution in lymph and plasma has been evaluated in rabbits. It has been shown that after i.m. administration of RIL-2 in saline, the lymphokine is preferentially absorbed via lymphatics. A similar result has been obtained after s.c. administration when RIL-2 was injected with a high concentration (12.5%) of human albumin, which acts as a retarder and a promoter of lymphatic absorption. These routes may be valid alternatives to i.v. administration.
Bocci
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V
Institute of General Physiology, University of Siena, Italy.
Pessina
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GP
Nicoletti
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C
Paulesu
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L
D000818:Animals; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008196:Lymph / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
D007376:Interleukin-2; D011994:Recombinant Proteins