Sperm-oolemmal interaction: role of the Arg-Gly-Asp (RGD) adhesion peptide.
The Arg-Gly-Asp tripeptide (RGD) plays a widespread role in cell-to-cell and cell-to-matrix recognition. We demonstrated that an RGD-containing peptide (Arg-Gly-Asp-Val, RGDV) inhibits both oolemmal binding and penetration of zona-free hamster eggs by human spermatozoa in vitro when added to the incubation medium. These results suggest that RGD-containing proteins may play a role in sperm-oolemmal interactions required for fertilization.
Department of Obstetrics and Gynecology, State University of New York, Stony Brook.
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D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D006224:Cricetinae; D005260:Female; D008297:Male; D009842:Oligopeptides / Q000502:physiology; D010063:Ovum / Q000187:drug effects / Q000502:physiology; D013084:Sperm-Ovum Interactions / Q000187:drug effects / Q000502:physiology*; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology
D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; C058347:glycyl-arginyl-glycyl-glutamyl-seryl-proline