Cathepsin D coexists with renin in the secretory granules of juxtaglomerular epithelioid cells.
Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin D-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin D is suggested to be involved in the regulation of the granular renin stores available for secretion.
Taugner
R
R
Yokota
S
S
Bührle
C P
CP
Hackenthal
E
E
D000818:Animals; D002402:Cathepsin D / Q000032:analysis*; D003594:Cytoplasmic Granules / Q000032:analysis* / Q000648:ultrastructure; D004848:Epithelium / Q000032:analysis / Q000648:ultrastructure; D006046:Gold; D006868:Hydrolysis; D007606:Juxtaglomerular Apparatus / Q000032:analysis* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000032:analysis*; D013194:Staining and Labeling
D006046:Gold; D012083:Renin; D002402:Cathepsin D