[Long-term gentamicin ototoxicity in the rat: research on retro-cochlear involvement by study of evoked auditory potentials of the brain stem].
Four groups of rats treated with single (50 mg/kg and 200 mg/kg) or multiple (3 X 200 mg/kg and 5 X 200 mg/kg) doses of gentamycin were studied over a 6-month period and compared with a control group. At 50 mg/kg no significant changes were observed. Significant signs of intoxication were observed at 200 mg/kg doses and at multiple doses. A significant lengthening of the latencies with changes in amplitude and a transitional increase in the auditory threshold were observed as early as the end of treatment. This was followed by a phase of amplitude decrease, a rise in auditory threshold and a decrease in latencies which remains unexplained.
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de Lavernhe-Lemaire
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Garand
D000758:Anesthesia; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects*; D004334:Drug Administration Schedule; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005839:Gentamicins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D000160:Vestibulocochlear Nerve Diseases / Q000139:chemically induced
D005839:Gentamicins
Ototoxicité à long terme de la gentamicine chez le rat: recherche d'une atteinte rétro-cochléaire par l'étude des potentiels évoqués auditifs du tronc cérébral.