[Attempts at a demonstration of cross reactivity between the HLA- antigens A2 and B12 or A1 and B8].
Using human anti-HLA-A1, A2, B8 and B12 sera the cross reactivity between HLA-antigens A1 and B8 or A2 and B12 respectively was investigated by means of the absorption test. A cross reactivity could be proved to exist between A2 and B12 antigens, but only with an anti-HLA-B12 serum which was adsorbed by A2 positive and B12 negative thrombocytes as well as by A2 negative and B12 positive ones. Thus, the conclusion may be drawn that this serum covers a determinant common to HLA-A2 and B12.
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Májský
D000042:Absorption; D001792:Blood Platelets / Q000276:immunology; D003429:Cross Reactions; D006680:HLA Antigens / Q000276:immunology*; D015788:HLA-A1 Antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D015795:HLA-B8 Antigen; D006801:Humans; D007962:Leukocytes / Q000276:immunology
D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D015795:HLA-B8 Antigen
Versuche zum Nachweis einer Kreuzreaktivität zwischen den HLA-Antigenen A2 und B12 bzw. A1 and B8.