[Blastomogenic activity of biogenic methoxyindoles].
A considerable blastogenic activity of biogenic methoxyindoles--melatonin, 5-methoxytryptamine (5-MOT) and their common metabolite--5-methoxyindolyl-3-acetic acid (5-MIAA) was established by prolonged s.c. injection in C57BL/6 mice. However, the blastogenic effect of 5-MOT decreased by 26% when its further metabolism to 5-MIAA was blocked for some time and the synthesis of its carcinogenic metabolite was inhibited. These results showed that the blastogenic effect of 5-MOT is not direct; and it is mediated by its transformation to 5-MIAA in the body.
Sergeeva
T I
TI
Romanenko
V I
VI
Malakhova
N V
NV
Raushenbakh
M O
MO
Suvorov
N N
NN
D008735:5-Methoxytryptamine / Q000633:toxicity*; D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008550:Melatonin / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014363:Tryptamines / Q000633:toxicity*
D014363:Tryptamines; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin
Blastomogennaia aktivnost' biogennykh metoksiindolov.