The use of erythrocytes for delivery of chemotherapeutic agents to the reticuloendothelial system.
The object of our work is to define the possible role of hypotonically loaded erythrocytes as carriers to target drugs to the reticuloendothelial system. We have examined choices of drugs for loading into the erythrocytes and have considered methods of altering potentially useful agents so that they will load. We have demonstrated that the delivery of bleomycin to the reticuloendothelial system of mice, inside erythrocyte carriers, potentiates the effect of this drug on phagocytosis. We speculate, that this targeted delivery of bleomycin to phagocytes could be beneficial in the treatment of diseases characterized by an important phagocytic component.
Lynch
W E
WE
Sartiano
G P
GP
Rosenblum
S L
SL
Calkins
J H
JH
Ramsey
C B
CB
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000494:pharmacology; D004912:Erythrocytes; D006801:Humans; D007038:Hypotonic Solutions; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles
D007038:Hypotonic Solutions; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D001761:Bleomycin