[Intraneuronal information processing. An increase in sodium and decrease in potassium permeability after injection of cyclic nucleotide and mechanical stimulation of the neuron].
In voltage clamp experiments the ionic permeability mechanism of the neuron soma evoked by the injection of cyclic nucleotides can be estimated only by studying the reversal potential. The value of this potential allows to conclude that permeability is mainly increased by opening potential independent sodium channels. A delay of ionic current evoked by cyclic nucleotides is tenfold less than the time of cAMP diffusion to the membrane. This leads to a hypothesis about the cyclic nucleotide dependent mechanical opening of sodium channels.
E A
EA
Liberman
S V
SV
Minina
O L
OL
Miakotina
N E
NE
Shklovskiĭ-Kordi
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D011312:Pressure; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D012964:Sodium; D000242:Cyclic AMP; D006152:Cyclic GMP; D011188:Potassium
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