Immunity targeting common core antigens of gram-negative bacteria.
Antibodies against common gram-negative core antigens can provide protection against environmental, commensual, and contagious bacteria that cause life-threatening gram-negative sepsis/endotoxemia. Cross-protective immunity may be effective against many common livestock diseases, including neonatal coliform septicemia, coliform mastitis, septic metritis, and severe enteritis. The greatest potential benefit of cross-protective immunity may be realized in the reduction of ill-thrift and mortality of neonates. The use of active and passive immunization against core antigens common to gram-negative bacteria has been successful in human beings, laboratory animals, and livestock. Protection has been observed following challenge with either heterologous endotoxin or unrelated, live, virulent gram-negative bacteria.
Department of Clinical Pathology, School of Veterinary Medicine, University of California, Davis.
J W
JW
Tyler
J S
JS
Cullor
S J
SJ
Spier
B P
BP
Smith
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D003429:Cross Reactions; D006090:Gram-Negative Bacteria / Q000276:immunology*; D006801:Humans; D007110:Immunity, Active; D007116:Immunization, Passive
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial