Germ cell tumor in the basal ganglia: immunohistochemical demonstration of alpha-fetoprotein, human chorionic gonadotropin, and carcinoembryonic antigen.
A case of germ cell tumor in the basal ganglia and its vicinity was successfully treated surgically and by radiation. alpha-Fetoprotein, human chorionic gonadotropin, and carcinoembryonic antigen were found in the tumor tissue, using the immunoperoxidase method. The presence of three immunohistochemically demonstrated tumor markers in a single germ cell tumor is extremely unusual. These results strongly suggest a cell differentiation or transformation in germ cell tumors.
Ono
N
N
Inoue
H K
HK
Naganuma
H
H
Misumi
S
S
Tamura
M
M
D000293:Adolescent; D001479:Basal Ganglia / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000032:analysis*; D004407:Dysgerminoma / Q000032:analysis* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007120:Immunochemistry; D008297:Male; D000509:alpha-Fetoproteins / Q000032:analysis*
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins