Comparative effects of an antiviral drug, inosiplex, and diphosphonates in Paget's disease of bone.
The effects of the antiviral agent, inosiplex, were assessed in four patients with Paget's disease of bone. Treatment for 6 months did not suppress disease activity as judged by serum alkaline phosphatase and hydroxyprolinuria, and viral inclusions persisted in the one patient from whom a bone biopsy was taken. These results contrasted markedly with the suppressive effects of diphosphonate treatment in these same patients.
Kanis
J A
JA
Preston
C J
CJ
Beard
D J
DJ
Beneton
M
M
Harris
S
S
Russell
R G
RG
D000469:Alkaline Phosphatase / Q000097:blood; D004002:Clodronic Acid / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000627:therapeutic use; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000627:therapeutic use*; D010001:Osteitis Deformans / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology
D004164:Diphosphonates; D004002:Clodronic Acid; D007288:Inosine; D000469:Alkaline Phosphatase; D012968:Etidronic Acid; D006909:Hydroxyproline; D007542:Inosine Pranobex