[Action of aminoglycosides on platelet aggregation in vitro].
The authors tested the influence of gentamicin, spectinomycin dihydrostreptomycin on the ADP and epinephrine in vitro induced platelet aggregation. Our aim was to demonstrate if platelet aggregation in vitro had some influences by antibiotics. A reduction in platelet aggregability, strictly dependent from the used antibiotic dose was observed. We have studied platelet function thanks to Born's method, adding to PRP gradual therapeutics doses of antibiotics. The results showed a reduction of platelet function which was dose-depended, and, particularly, gentamicin seemed to be the most effective among aminoglycosides. An interference between these drugs and the ADP and epinephrine binding to specific platelet receptor sites is proposed.
Nubile
G
G
Saccone
A
A
Di Gregorio
M
M
Rossi
M
M
Tresca
E
E
D000244:Adenosine Diphosphate / Q000494:pharmacology; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D000198:Spectinomycin / Q000494:pharmacology*
D005839:Gentamicins; D000244:Adenosine Diphosphate; D000198:Spectinomycin; D004096:Dihydrostreptomycin Sulfate; D004837:Epinephrine
L'azione degli aminoglicosidi sulla aggregazione piastrinica in vitro.