Mutagenic and genotoxic effects of aqueous extracts of Achyrocline satureoides in prokaryotic organisms.
Aqueous extracts of Achyrocline satureoides (Marcela and/or Macela) were tested for the presence of genotoxic activity in microorganisms. This species belongs to the family Compositae and is used on a large scale by the population of South Brazil. The extracts showed genotoxic activity in the presence of S9 mix in the Ames test TA100, TA98 and TA102 strains, 'SOS' spot chromotest and Microscreen phage-induction assay. The positive results were related to the presence of quercetin and caffeic acid in the aqueous extracts.
Departamento do Meio Ambiente, Porto Alegre, RS, Brazil.
V M
VM
Vargas
V E
VE
Motta
A C
AC
Leitão
J A
JA
Henriques
D000818:Animals; D001435:Bacteriophages / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects; D015394:Molecular Structure; D009153:Mutagens; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013014:SOS Response, Genetics / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects
D009153:Mutagens; D010936:Plant Extracts