Histochemical study of R1881-binding protein, prostatic acid phosphatase, prostate-specific antigen, and r-seminoprotein in prostatic cancer.
A histochemical study on R1881-binding protein, prostatic acid phosphatase (PAP), prostate-specific antigen (PA) and r-seminoprotein was conducted. These parameters and histologic grades were compared to each other and with the responsiveness to endocrine therapy. A good correlation was found between histologic grade and presence or absence of R1881-binding protein in the tissue. Presence or absence of R1881-binding protein as well as histologic grade correlated well with responsiveness to endocrine therapy. Positive staining patterns of PAP, PA, and r-seminoprotein in the tissues were similar to each other, particularly between PA and r-seminoprotein. However, no correlation was found between the histologic grade and ratios of PAP, PA or r-seminoprotein-positive cells. Nor was any correlation seen between the ratio of these marker-positive cells and responsiveness to endocrine therapy.
Ito
H
H
Yamaguchi
K
K
Sumiya
H
H
Matsuzaki
O
O
Shimazaki
J
J
D000135:Acid Phosphatase / Q000032:analysis*; D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology / Q000628:therapy; D000727:Androgen-Binding Protein / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D004967:Estrogens / Q000627:therapeutic use; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009919:Orchiectomy; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000473:pathology / Q000628:therapy; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000032:analysis*; D029589:Seminal Plasma Proteins
D000727:Androgen-Binding Protein; D000951:Antigens, Neoplasm; D004967:Estrogens; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; C028867:methyltrienolone binding protein, human; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen