Vasoactive intestinal polypeptide response to ethanol in dogs.
Only one report has described the ethanol-induced release of vasoactive intestinal polypeptide (VIP), and its mechanism of action is unknown. We studied changes in mesenteric immunoreactive VIP (IR-VIP) concentrations following the intrajejunal administration of 100 ml of normal saline, 5% and 10% ethanol, and hypertonic saline which was isoosmolar to 10% ethanol (1,670 mOsm/liter) in dogs. Administration of 5% and 10% ethanol resulted in significant and dose-dependent increases in mesenteric IR-VIP. Mesenteric IR-VIP changes and incremental integrated responses to 10% ethanol and to hypertonic saline were the same. We concluded that ethanol-induced VIP release in dogs is mainly due to ethanol's hyperosmolarity.
Misawa
T
T
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
Aramaki
J
J
Chijiiwa
Y
Y
Kabemura
T
T
Nasu
T
T
Nawata
H
H
D000818:Animals; D004285:Dogs; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008642:Mesenteric Veins; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000378:metabolism*
D012462:Saline Solution, Hypertonic; D014660:Vasoactive Intestinal Peptide; D000431:Ethanol