Reduction of thrombogenicity in small-diameter vascular prostheses seeded with autologous endothelial cells.
In a canine model small-diameter vascular grafts of knitted Dacron were seeded with autologous endothelial cells. Four weeks after surgery the grafts were removed. Seeded grafts showed a pseudo-intima covered by a monolayer, whereas control grafts showed a cellular lining only at the anastomoses. Graft pretreatment with either fibrin glue or autologous blood in combination with endothelial cell seeding promoted the neointima formation.
G B
GB
Köveker
K H
KH
Petzke
M
M
Borg
K
K
Nebendahl
D000818:Animals; D001769:Blood; D001807:Blood Vessel Prosthesis; D004285:Dogs; D004727:Endothelium / Q000166:cytology; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D005337:Fibrin / Q000627:therapeutic use; D008954:Models, Biological; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications / Q000517:prevention & control; D013927:Thrombosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
D011093:Polyethylene Terephthalates; D005337:Fibrin