The influence of plasma volume expanders on initial haemostasis in the rabbit mesentery.
An experimental study was undertaken to evaluate the effect of dose (1 and 2 g/kg b.w.) and molecular weight (40 000, 70 000, 110 000 and 500 000 daltons) of dextran on primary haemostatic plug formation in the rabbit mesenteric microcirculation. All experiments were made 3 h after the infusion of the different substances. Albumin and hydro-oxyethyl starch treatment was used for control plasma volume expansion and did not influence arteriolar and venular haemostasis as compared with saline. Dextran gave a prolonged haemostatic plug formation time with increasing dose and with increasing molecular weights. Clinically relevant doses of dextran 40 and 70 (1 g/kg b.w.) did not influence haemostatic plug formation time.
Bergqvist
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D000818:Animals; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008643:Mesentery / Q000098:blood supply; D008833:Microcirculation / Q000187:drug effects; D008970:Molecular Weight; D010952:Plasma Substitutes / Q000494:pharmacology*; D011817:Rabbits
D003911:Dextrans; D010952:Plasma Substitutes