Kinin effects on ion transport in monolayers of HCA-7 cells, a line from a human colonic adenocarcinoma.
Using epithelial monolayers of HCA-7 cells, derived from a primary human colonic adenocarcinoma and grown on pervious supports, it is shown that responses to lysylbradykinin can be elicited from either side. It is proposed that kinin receptors are inserted into both apical and basolateral membrane domains.
Cuthbert
A W
AW
Kirkland
S C
SC
MacVinish
L J
LJ
D000230:Adenocarcinoma / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology; D002460:Cell Line; D003110:Colonic Neoplasms / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D007705:Kinins / Q000494:pharmacology*
D007473:Ion Channels; D007705:Kinins; D001920:Bradykinin