[Synthesis of cyclic and cyclically branched tachykinin partial sequences. 1. Synthesis of the homodet-cyclic eledoisin(6-11)-hexapeptide].
Ala-Phe-Ile-Gly-Leu-Met has been disengaged by cyclization of H-Leu-Met-Ala-Phe-Ile-Gly-OH by means of dicyclohexylcarbodiimide/N-Hydroxysuccinimide or the adequate p-nitrophenylester. Acc. to various strategic variants, the design of the linear precursor has been performed by condensation of the segments of Boc-Leu-Met-OH and H-Ala-Phe-Ile-Gly-OH. The resulting cyclo-[Eledoisin(6-11)-Hexapeptide] has in a clearly separated range of dose dual agonistic and antagonistic effects at the guinea-pig ileum.
K
K
Neubert
J
J
Bergmann
J
J
Mansfeld
B
B
Hartrodt
A
A
Barth
H D
HD
Jakubke
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004600:Eledoisin / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology
D010446:Peptide Fragments; D013373:Substance P; C046755:eledoisin (6-11); D004600:Eledoisin; D000109:Acetylcholine
Synthese cyclischer und cyclisch-verzweigter Tachykinin-Teilsequenzen. Teil 1: Darstellung des homodet-cyclischen Eledoisin(6-11)-Hexapeptides.