Electrophoretic variants of alpha 2u-globulin in the livers of adult male rats: a possible polymorphism.
Two-dimensional polyacrylamide gel electrophoresis has been used to examine the microsomal fractions from the livers of 32 adult male Alpk/AP (Wistar-derived) rats for the presence of alpha 2u-globulin variants of differing isoelectric point. Three major such isoelectric variants are described. Different combinations of these three forms were found in the population examined, with one-half of the animals expressing all three variants in approximately equal proportions and with one variant being present in all the animals examined. An understanding of the relevance of such different alpha 2u-globulin profiles to the individual animal must now await the assignment of a biological role for alpha 2u-globulin.
B M
BM
Elliott
R
R
Ramasamy
M D
MD
Stonard
S P
SP
Spragg
D000510:Alpha-Globulins / Q000235:genetics / Q000302:isolation & purification*; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007525:Isoelectric Focusing; D007526:Isoelectric Point; D008297:Male; D008862:Microsomes, Liver / Q000032:analysis*; D011110:Polymorphism, Genetic; D051381:Rats
D000510:Alpha-Globulins; C013803:alpha 2u globulin