Polymorphism of debrisoquine 4-hydroxylation and family studies of poor metabolizers in Chinese population.
Debrisoquine hydroxylation capacity determined as the ratio of debrisoquine over 4-OH-debrisoquine in 8-h urine after a single dose (10 mg) was studied in 140 unrelated Chinese Han subjects and 2 families of poor metabolizers (PM) of debrisoquine. In the 140 Chinese subjects the frequency of PM was found to be 1.43% (2/140), much lower than the 5-10% in white population reported. No sex difference was shown on the hydroxylation of debrisoquine. The recoveries of debrisoquin, 4-OH-debrisoquine in 8-h urine were 16 +/- 11 and 13 +/- 6%, respectively. None of the parents in the 2 families was PMs. Phenotype distribution in each family and population was consistent with the hypothesis that debrisoquine 4-OH-hydroxylation activity is under diallelic, monogenetic control, with the PM phenotype inheriting in an autosomal recessive trait.
Du
Y L
YL
Department of Pharmacology, Beijing Medical University, China.
Lou
Y Q
YQ
D000293:Adolescent; D000328:Adult; D044466:Asian People; D002681:China / Q000453:epidemiology; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine*; D005260:Female; D006801:Humans; D015994:Incidence; D007546:Isoquinolines / Q000378:metabolism* / Q000652:urine*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000453:epidemiology* / Q000235:genetics; D010375:Pedigree; D011110:Polymorphism, Genetic
D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003647:Debrisoquin