Rheological studies on patients with posterior subretinal neovascularization and exudative age-related macular degeneration.
To investigate the potential influence of a decreased perfusion rate of the choriocapillaris on the development of age-related macular degeneration (ARMD) with subretinal neovascularization (SRNV) apparently caused by disturbed flow properties of blood, we compared the hemorheological parameters of blood from 35 patients suffering from ARMD with SRNV with those from the 35 healthy patients of the same age. In both groups hematocrit, plasma viscosity, erythrocyte filtrability, aggregation, aggregating proteins, leukocyte and thrombocyte count, differentiation of leukocytes, thrombelastography, PTT, Quick test, and rheological profiles were comparable. The differences were not significant (P greater than 0.05). These results refute the hypothesis that changed flow properties of blood are the primary cause of the pathogenesis of ARMD with SRNV.
Inhoffen
W
W
Universitäts-Augenklinik, Bonn, Federal Republic of Germany.
Nüssgens
Z
Z
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001780:Blood Coagulation Tests; D001809:Blood Viscosity; D004909:Erythrocyte Indices; D005260:Female; D006400:Hematocrit; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000209:etiology / Q000503:physiopathology*; D012212:Rheology; D012307:Risk Factors