Clustered homeo boxes are differentially expressed during murine development.
A murine homeo box (m6-12) known to be expressed during differentiation of embryonal carcinoma cells lies within a cluster of homeo boxes located in 30 kilobase pairs of genomic DNA. We have established the organization of the boxes within this complex, as well as the nucleotide sequence of a second box, m5-4. Similar to the m6-12 box, expression of novel m5-4 transcripts is induced upon differentiation of embryonal carcinoma cells. Transcripts of genes containing m6-12 were found in embryonic tissue during almost all stages of prenatal development studied, whereas expression of m5-4 was detected only in 12 day embryonic tissue. Finally, we have described the differential expression of these homeo-box-containing regions in various adult tissues.
Colberg-Poley
A M
AM
Voss
S D
SD
Chowdhury
K
K
Stewart
C L
CL
Wagner
E F
EF
Gruss
P
P
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004622:Embryo, Mammalian / Q000502:physiology*; D054278:Embryonal Carcinoma Stem Cells; D005786:Gene Expression Regulation; D005796:Genes; D051379:Mice; D008813:Mice, Inbred ICR; D009024:Morphogenesis; D014411:Neoplastic Stem Cells / Q000032:analysis; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000032:analysis; D014176:Protein Biosynthesis; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger; D012689:Sequence Homology, Nucleic Acid; D013724:Teratoma; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011061:Poly A; D012313:RNA