Intimal thickening and the distribution of vasomotor nerves in the mechanically injured dog coronary artery.
Intimal injury and atherosclerotic change seem to be causative factors linked to spasm of the coronary artery. Intimal thickening was produced by mechanical injury to the endothelium of the canine coronary artery and we investigated the distribution of adrenergic, cholinergic, and peptidergic nerves in the coronary arteries. Although adrenergic and cholinergic nerves were not altered in density, neuron specific enolase positive nerve fibers were increased in number in dogs killed 1 and 3 months after injury. Substance P-containing fibers were also increased at 3 months after the induced injury.
T
T
Taguchi
Y
Y
Ishii
F
F
Matsubara
K
K
Tanaka
D000110:Acetylcholinesterase / Q000502:physiology; D000818:Animals; D003329:Coronary Vasospasm / Q000473:pathology; D003331:Coronary Vessels / Q000293:injuries / Q000294:innervation* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D010751:Phosphopyruvate Hydratase / Q000502:physiology; D013194:Staining and Labeling; D013373:Substance P / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D000110:Acetylcholinesterase; D010751:Phosphopyruvate Hydratase; D009638:Norepinephrine