[The effects on the learning process of 4 pyrrolidine derivatives and of cyticholine (experiments on rats in a water maze)].
The experiments were carried out on 104 male white rats and the effects of pyracetamat, aniracetamat and 2 newly synthesized pirolidine derivatives P-CL, P-p as well as of cytidin-diphosphat choline (cyticholine) were examined on training in a water maze. All investigated substances were administered immediately after morning training orally in a dose of 100 mg/kg for a period of 5 days. Ten trainings were undertaken each day twice. Two parameters were determined: time of stay of the rat in the water maze (in seconds) and the number of mistakes (entrance of blind canals). Pyracetamat and cyticholine improved training of rats while the other examined substances showed insignificant effect. A conclusion is made that chemically close nootropic drugs could be differentiated substantially in respect to spatial memory as well.
Getova
D
D
Petkov
V
V
D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013550:Swimming
D011759:Pyrrolidines; D003566:Cytidine Diphosphate Choline; D002794:Choline
Prouchvane na efektite vŭrkhu obuchitelniia protses na 4 pirolidinovi proizvodni i na tsitikholina (opiti vŭrkhu plŭkhove vŭv voden labirint).