McCune-Albright syndrome: the patterns of scintigraphic abnormalities.
This study of 22 patients with the McCune-Albright syndrome examined the scintigraphic distribution of fibrous dysplasia. The most frequently affected areas were the base of the skull (82% of patients), mandible (50%), facial bones (45%), femora (59%), and legs (64%). The least frequently affected areas included the hands (none), wrists (none), ankles (none), feet (5%), sacrum (5%), and vertebrae (9%). The distribution varied somewhat from idiopathic fibrous dysplasia but generally agreed with the distributions reported in radiographic studies of patients with the McCune-Albright Syndrome. The serum alkaline phosphatase was not an accurate predictor of the extent of fibrous dysplasia.
Department of Nuclear Medicine, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
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Pfeffer
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Molina
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Feuillan
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Simon
D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging*; D005359:Fibrous Dysplasia, Polyostotic / Q000000981:diagnostic imaging*; D006801:Humans; D011877:Radionuclide Imaging