Cardiac function of WHHL rabbit, an animal model of familial hypercholesterolemia.
To investigate the cardiac function of WHHL rabbit (WHHL), an animal model of familial hypercholesterolemia, electrocardiography (ECG) and echocardiography (UCG) were taken from this species of homozygous type and normolipidemic Japanese White rabbits (controls). In WHHL, two of four had intraventricular conduction disturbances (IVCD) in ECG. UCG study showed that the ejection fraction significantly increased (p less than 0.05) and deceleration time was shortened (p less than 0.01) in WHHL compared to normal controls.
Saku
K
K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Fujino
M
M
Yamamoto
K
K
Ying
H
H
Tashiro
N
N
Harada
R
R
Okabe
M
M
Arakawa
K
K
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011817:Rabbits