Reevaluation of Russell-Silver syndrome.
Russell-Silver syndrome was reevaluated 2.9 to 13.0 years after initial diagnosis in 15 patients. At follow-up, five of the 15 patients exhibited late catch-up growth and had normal height, six had developmental delays or mental retardation, and asymmetry was present in five. Given the great variability in the long-term prognosis for growth and development in patients with Russell-Silver syndrome, there is a need to reevaluate this syndrome and its clinical implications.
H M
HM
Saal
R A
RA
Pagon
M G
MG
Pepin
D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000503:physiopathology; D005149:Facial Expression; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000175:diagnosis; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000503:physiopathology; D012741:Sexual Maturation; D013577:Syndrome; D013997:Time Factors