The effects of changes in intracellular calcium on rat synaptosomal cyclic adenosine monophosphate.
Cyclic adenosine monophosphate (cAMP) concentration was measured in rat striatal and hippocampal synaptosomes. Incubation in 50 mM K+ medium caused a decrease in both striatal and hippocampal cAMP: this effect was dependent on extracellular Ca2+. Replacement of NaCl with sucrose in the incubation medium increased cAMP. Incubation with 0.5 mM ouabain was without effect.
Ryan
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E
Fillenz
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M
D000818:Animals; D002118:Calcium / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D000242:Cyclic AMP / Q000032:analysis*; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000502:physiology; D013574:Synaptosomes / Q000032:analysis*
D007473:Ion Channels; D010042:Ouabain; D012964:Sodium; D000242:Cyclic AMP; D011188:Potassium; D002118:Calcium