[Enhancement of absorption of tetramethylpyrazine by synthetic borneol].
Sprague-Dawley rats were given ig tetramethylpyrazine phosphate (TMP) 5 mg/kg with or without previous borneol 5 mg/kg. The plasma TMP concentrations were analysed by GC method, and the data were treated by NONLIN program. The Cmax were 931 and 562 ng/ml, respectively, (P less than 0.01); while the AUC were 68,849 and 37,174, respectively, (P less than 0.05). It is suggested that the borneol enhances the absorption of the TMP but not in elimination.
Chen
T F
TF
Division of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou, China.
Lin
S G
SG
Chen
L X
LX
Jiang
G F
GF
Liang
Z Y
ZY
Yang
M
M
Qian
Y Z
YZ
Xie
Y A
YA
D000042:Absorption; D000818:Animals; D001892:Camphanes / Q000494:pharmacology; D002164:Camphor / Q000494:pharmacology*; D002849:Chromatography, Gas; D011719:Pyrazines / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents / Q000493:pharmacokinetics*
D001892:Camphanes; D011719:Pyrazines; D014665:Vasodilator Agents; D002164:Camphor; C022871:isoborneol; C017953:tetramethylpyrazine