Immunochemical evidence for substance P-like peptide in tissues of the earthworm Lumbricus terrestris: action on intestinal contraction.
The presence of a substance P-like peptide in intestinal and body wall tissues, ventral nerve fiber and seminal vesicles of the earthworm Lumbricus terrestris has been demonstrated by means of a radioimmunoassay technique. The greatest substance P-like immunoreactivity was measured in intestinal tissues where it stimulates the rate of spontaneous contraction. This effect is inhibited by the substance P antagonist (D-pro2, D-trp7,9)-SP suggesting a possible involvement of receptor mechanisms. Dual localization of substance P-like immunoreactivity in earthworm intestinal and nerve tissues follows the pattern observed of peptidal hormones in vertebrates which are common to both endocrine and non-endocrine tissues.
K V
KV
Kaloustian
J A
JA
Edmands
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D007120:Immunochemistry; D007422:Intestines / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009835:Oligochaeta / Q000378:metabolism*; D011863:Radioimmunoassay; D013373:Substance P / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000502:physiology
D013373:Substance P; D000109:Acetylcholine