Familial occurrence of KID (keratitis, ichthyosis, deafness) syndrome. Case reports of a mother and daughter.
Keratitis, ichthyosis, and deafness (KID) syndrome in a mother and her daughter is reported. Both patients showed the typical cutaneous abnormality of papillomatous hyperkeratosis, which gave the skin a grainy, rugose, spiculated appearance, together with keratitis with corneal neovascularization and a neurosensory hearing defect. Treatment with etretinate did not benefit the daughter. The mother had marked keratitis with progressive corneal opacification that required repeated bilateral corneal grafts, which were unsuccessful. This is the second report of hereditary transmission of this disorder. An autosomal dominant mode of inheritance is probable.
Unité de Recherche sur le Diagnostic Anténatal en Dermatologie, Hôpital Saint-Louis, Paris.
V
V
Nazzaro
C
C
Blanchet-Bardon
G
G
Lorette
J
J
Civatte
D000328:Adult; D016039:Corneal Transplantation; D003638:Deafness / Q000235:genetics*; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000235:genetics*; D007634:Keratitis / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D008875:Middle Aged; D013577:Syndrome
D005050:Etretinate