Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: lack of association with affective illness.
The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r = -.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.
E
E
Richelson
K
K
Snyder
J
J
Carlson
M
M
Johnson
S
S
Turner
A
A
Lumry
E
E
Boerwinkle
C F
CF
Sing
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D001782:Blood Donors; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism*; D008297:Male; D010641:Phenotype; D012737:Sex Factors
D005819:Genetic Markers; D007473:Ion Channels; D008094:Lithium