Interferon induction by viruses. XIII. Detection and assay of interferon induction-suppressing particles.
An assay is described for detecting and measuring the capacity of a single virus particle to suppress completely the yield of interferon from a cell otherwise competent to product interferon. The assay defines virus populations in terms of a newly quantifiable attribute--interferon induction-suppressing particles (ISP). The antagonistic actions of interferon-inducing particles and interferon induction-suppressing particles are thought to determine the interferon-inducing capacity intrinsic to a virus population.
Marcus
P I
PI
Sekellick
M J
MJ
D000818:Animals; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics; D007700:Kinetics; D007739:L Cells; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology*; D013045:Species Specificity; D014158:Transcription, Genetic; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology*
D007369:Interferon Inducers; D007372:Interferons