The interaction of acetylcholinergic and serotonergic neural systems on performance in a continuous non-matching to sample task.
The interactions of cholinergic and serotonergic neural systems were investigated in a working memory, continuous non-matching-to-sample task in an operant chamber. Each rat was injected (i.p.) with scopolamine and/or methysergide. The serotonergic system was destroyed by p-chloroamphetamine (PCA) injection. Scopolamine, but not PCA, impaired response accuracy. The effects of methysergide and scopolamine together were not different from scopolamine alone. Scopolamine had a significantly smaller effect on choice accuracy in PCA-treated than in untreated rats.
Sakurai
Y
Y
Department of Psychology, Toyama Medical and Pharmaceutical University, Japan.
Wenk
G L
GL
D000109:Acetylcholine / Q000502:physiology*; D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000502:physiology*; D004192:Discrimination, Psychological / Q000187:drug effects; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects; D008784:Methysergide / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D051381:Rats; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000502:physiology*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D012701:Serotonin; D010133:p-Chloroamphetamine; D007650:Ketanserin; D000109:Acetylcholine; D008784:Methysergide