Studies on immunity in hybridoma-bearing mice. B. Immunity against the hybridoma. II. The phenotype and specificity of the immune cell.
When appropriate numbers of anti-dinitrophenyl (DNP) immunoglobulin (Ig) E-secreting hybridoma (B 53) cells were injected s.c. into normal BALB/c mice, some of the recipients rejected the tumors. These mice were shown to be immune to B 53 as they withstood, without any ill effect, the i.p. injection of lethal doses of B 53 cells. In previous studies, it was shown that the spleen cells of these mice protected against the growth of B 53 cells. In this study, the characteristics and specificity of the immune spleen cells were examined. The cells responsible for this immunity were shown to be T cells that express Ly-2 on their surface. These cells were shown in in vivo and in vitro assays to limit the growth of the immunizing hybridoma, as well as some but not all BALB/c plasmacytomas and hybridomas.
Maekawa
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D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002860:Chromium Radioisotopes / Q000378:metabolism; D000939:Epitopes / Q000032:analysis*; D005260:Female; D006825:Hybridomas / Q000145:classification / Q000276:immunology*; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D010954:Plasmacytoma / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000951:Antigens, Neoplasm; D002860:Chromium Radioisotopes; D000939:Epitopes