Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates.
Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were found in a broad range of organisms including the vertebrates. Control experiments indicate that the search predicts known false positives at a rate of only 20%. Trans-splicing may therefore be a very wide-spread phenomenon.
Dandekar
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European Molecular Biology Laboratory, Heidelberg, FRG.
Sibbald
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PR
D000818:Animals; D001483:Base Sequence; D006801:Humans; D007256:Information Systems; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010802:Phylogeny; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D012326:RNA Splicing
D012322:RNA Precursors