Increase of blood flow in skin and spinal cord following activation of small diameter primary afferents.
Activation of unmyelinated primary afferents produces vasodilatation and plasma extravasation in the skin. Here, using the laser Doppler technique to measure changes in blood flow and the Evans blue technique for quantification of plasma extravasation, we have asked whether the stimulation of C-fibre precipitates the same phenomena in the spinal cord. Our results show that there is an increase of blood flow, but no extravasation in the ipsilateral lumbar enlargement of the spinal cord following supramaximal electrical stimulation of the sciatic nerve. The blood flow increases were small and short-lived compared with those seen in skin, and could be completely explained by concomitant blood pressure changes. Hence, whilst the same substances are apparently released from the peripheral and central terminals of primary afferent fibres, their ability to produce vasodilatation and extravasation is absent or severely restricted in the spinal cord.
Sherrington School of Physiology, United Medical, Dental School, London, U.K.
M
M
Koltzenburg
G
G
Lewin
S
S
McMahon
D000818:Animals; D001783:Blood Flow Velocity; D005260:Female; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology*; D051381:Rats; D012867:Skin / Q000294:innervation; D012879:Skin Physiological Phenomena; D013116:Spinal Cord / Q000502:physiology*; D014463:Ultrasonography; D014664:Vasodilation