Nucleic acids as analytes in laboratory diagnosis.
The method of nucleic acid hybridization opens up new possibilities in laboratory diagnosis. This method, which enables us to assay for definite nucleic acid sequences in the specimen, has the advantage of high specificity and a strong binding force between the analyte nucleic acid and the nucleic acid probe. So far this method primarily works with radioactive labels. The development of non-radioactive detection systems suited for routine laboratories with sufficient sensitivity is still at its origin. One broad field of application for nucleic acid hybridization is the detection of the genome of certain viruses or bacteria in the specimen. Another more future oriented potential of these methods lies in the investigation and diagnosis of inborn errors of metabolism.
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D001424:Bacterial Infections / Q000175:diagnosis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000032:analysis / Q000235:genetics; D005814:Genes, Viral; D006801:Humans; D007118:Immunoassay; D007158:Immunologic Techniques; D009693:Nucleic Acid Hybridization; D009695:Nucleic Acid Renaturation; D009696:Nucleic Acids / Q000032:analysis* / Q000235:genetics; D010761:Phosphorus Radioisotopes; D012313:RNA / Q000032:analysis / Q000235:genetics; D011868:Radioisotopes; D014777:Virus Diseases / Q000175:diagnosis
D009696:Nucleic Acids; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D012313:RNA; D004247:DNA