Synergistic enhancement of the bleomycin and peplomycin induced mitotic index reduction by verapamil.
The cytostatics bleomycin and peplomycin are known to reduce the mitotic index. It is shown that in cultured human lymphocytes the heart drug verapamil (Isoptin) increases this effect synergistically. This seems to be for the first time that synergism in the reduction of the mitotic index by chemical agents has been demonstrated.
Scheid
W
W
Traut
H
H
D000328:Adult; D001761:Bleomycin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007399:Interphase / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects*; D017663:Peplomycin; D014700:Verapamil / Q000494:pharmacology*
D001761:Bleomycin; D017663:Peplomycin; D014700:Verapamil