[Effect of retinoic acid on indices of humoral immunity].
The influence of all-trans- and 13-cys-methylretinoate on antibacterial and antiviral immunity was studied in experiments on noninbred C57Bl/6 and (CBA X C57Bl/6) F1 mice. All-trans-methylretinoate was shown to stimulate the production of antibodies to E. coli antigens, with the effect being dose-dependent. At the same time both compounds inhibited the production of inhibitors, interferon and antibodies to influenza virus.
Nozdrin
V I
VI
Orlova
A V
AV
Nikiforov
S A
SA
Manakhova
L S
LS
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation / Q000187:drug effects*; D004224:Diterpenes; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology; D000084562:Retinyl Esters; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C009166:retinol acetate; D014212:Tretinoin; D007372:Interferons; C026296:methyl retinoate
Vliianie retinoevoĭ kisloty na nekotorye pokazateli gumoral'nogo immuniteta.