Effect of fatty-acyl-CoAs on the elongation of saturated fatty acid in porcine aorta microsomes.
The microsomal elongation system from porcine aorta for longchain fatty-acyl-CoAs was investigated. Palmitoleoyl-CoA (16:1-CoA), oleoyl-CoA (18:1-CoA), and eicosenoyl-CoA (20:1-CoA) remarkably depressed the elongation activity for 16:0-CoA in aorta microsomes by 44.8, 52.4, and 43.7% of the control activity, respectively. Saturated and polyunsaturated fatty-acyl-CoAs had little effect on the 16:0-CoA elongation activity. These results indicate that monounsaturated long-chain fatty acyl-CoAs can regulate the synthesis of saturated fatty acids in the vessel walls.
Department of Biochemistry, Medical College of Oita, Japan.
K
K
Murakami
S
S
Yoshida
M
M
Takeshita
D000214:Acyl Coenzyme A / Q000378:metabolism* / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000378:metabolism*; D007700:Kinetics; D008861:Microsomes / Q000378:metabolism*; D010171:Palmitoyl Coenzyme A / Q000378:metabolism*; D013552:Swine
D000214:Acyl Coenzyme A; D005227:Fatty Acids; D010171:Palmitoyl Coenzyme A