[Effect of salvin on the synthesis of macromolecules in Staphylococcus aureus 209P].
The effect of salvin and its active component, carnazolic acid, on the synthesis of macromolecular compounds in the cells of S. aureus 209P was studied. It was shown that the inhibitory action of salvin on the synthesis of peptidoglycane in the culture was defined by the presence of carnazolic acid in its composition. In the bactericidal concentration, carnazolic acid was twice as less active as salvin and inhibited incorporation of labeled precursors into RNA and protein. The findings grounded the conclusion that some nonidentified components of salvin with low antimicrobial activity contained in it in insignificant quantities had an additional inhibitory effect on the process. Comparative study of salvin and antibiotics with the known mechanisms of action such as benzyl penicillin or chloramphenicol revealed a certain similarity in the action of salvin and benzyl penicillin on incorporation of labeled precursors into the macromolecular compounds of S. aureus 209P.
Smirnov
V V
VV
Pavlenko
L V
LV
Mashkovskiĭ
N N
NN
D045784:Abietanes; D002855:Chromatography, Thin Layer / Q000379:methods; D003470:Culture Media; D003864:Depression, Chemical; D004224:Diterpenes; D066298:In Vitro Techniques; D010457:Peptidoglycan / Q000032:analysis / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D010616:Phenanthrenes / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D013211:Staphylococcus aureus / Q000378:metabolism*
D045784:Abietanes; D003470:Culture Media; D004224:Diterpenes; D010457:Peptidoglycan; D010616:Phenanthrenes; D010936:Plant Extracts; C018381:salvin
Deĭstvie sal'vina na sintez makromolekul Staphylococcus aureus 209P.