Variations of brain histamine levels in germ-free and nephrectomized rats.
The influence of nephrectomy on brain and peripheral tissue histamine and on brain norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid was studied in germ-free and conventionally housed rats. The conventional controls had higher levels of histamine in the hypothalamus than the germ-free control animals, but no differences existed for histamine in whole brain minus the hypothalamus or in peripheral tissues. Nephrectomy increased brain histamine and 5-hydroxyindoleacetic acid levels in both germ-free and conventional rats, but had no effect on norepinephrine, dopamine or serotonin. In contrast, the histamine level in the heart of the nephrectomized germ-free animals was lower than that for germ-free controls. There were no changes in the heart or liver histamine levels of the conventional nephrectomized rats.
L R
LR
Hegstrand
R J
RJ
Hine
D000818:Animals; D001921:Brain / Q000502:physiology; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000032:analysis; D005856:Germ-Free Life; D006632:Histamine / Q000032:analysis*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D009392:Nephrectomy; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006632:Histamine; D004298:Dopamine; D009638:Norepinephrine