Vitamin D status of ambulatory and nonambulatory mentally retarded children with and without carbamazepine treatment.
The subjects consisted of four groups: group 1 nonambulatory patients receiving carbamazepine; group 2 ambulatory patients receiving carbamazepine; group 3 nonambulatory patients receiving no drug, and group 4 ambulatory patients receiving no drugs. The serum 25-hydroxyvitamin D (25-OH-D) concentration was significantly lower in group 1 than in all other groups. There was no difference between the groups as regards the serum 1,25-dihydroxyvitamin D or 24,25-dihydroxyvitamin D concentration. Carbamazepine treatment lowers the serum 25-OH-D concentration, and inactivity which leads to a lower degree of time spent out-of-doors and thus a low exposure to sunlight still decreases the concentration. In this study a low dietary vitamin D intake probably was an aggravating factor.
Endocrine Research Laboratory, University of Helsinki, Finland.
C
C
Lamberg-Allardt
M
M
Wilska
K L
KL
Saraste
T
T
Grönlund
D000293:Adolescent; D000328:Adult; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002220:Carbamazepine / Q000627:therapeutic use*; D004032:Diet; D004435:Eating; D015444:Exercise; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy / Q000378:metabolism*; D014807:Vitamin D / Q000097:blood / Q000502:physiology*
D014807:Vitamin D; D002220:Carbamazepine; D002117:Calcitriol; D002112:Calcifediol