Fatty liver hepatitis and type 5 hyperlipoproteinemia in juvenile diabetes mellitus. Case report and review of the literature.
A 28-year-old man with poorly controlled juvenile-onset diabetes mellitus presented with jaundice and type 5 hyperlipoproteinemia. A liver biopsy showed fatty liver hepatitis (steatonecrosis). This case represents one end in a spectrum of lipid disorders and liver disease in diabetes mellitus. With increasing insulin deficiency, liver steatosis and the more common type 4 hyperlipoproteinemia pattern may progress to fatty liver hepatitis and type 5 hyperlipoproteinemia.
Department of Medicine and Hepatology, University Hospital Gasthuisberg, Leuven, Belgium.
J
J
Lenaerts
L
L
Verresen
W
W
Van Steenbergen
J
J
Fevery
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004586:Electrophoresis; D005218:Fat Necrosis / Q000150:complications* / Q000473:pathology; D006505:Hepatitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000150:complications; D006954:Hyperlipoproteinemia Type V / Q000150:complications*; D008055:Lipids / Q000097:blood; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis / Q000150:complications*
D008055:Lipids