Anticoagulant activity of dextran derivatives. Part II: Mechanism of thrombin inactivation.
The mechanism of anticoagulant activity of dextrans substituted with carboxylic and benzylamide sulphonate groups is studied by various coagulation tests. These derivatives exhibit a heparin-like antithrombic activity which requires the presence of antithrombin III; however they are less effective than heparin on a weight basis. They also exert a direct antithrombic activity by an antithrombic III independent pathway; but this action is negligible compared to the thrombin inhibition observed in the presence of antithrombin III. Dextran derivatives have been prepared with antithrombic properties similar to those of heparin.
A M
AM
Fischer
M
M
Mauzac
J
J
Tapon-Bretaudiere
J
J
Jozefonvicz
D000990:Antithrombin III / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D003911:Dextrans / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
D003911:Dextrans; D000990:Antithrombin III; D013917:Thrombin