[The effect of IL-2 injection around the metastatic cervical lymphnode].
Six patients with squamous cell carcinoma of head and neck were treated with injection of interleukin-2 (IL-2) around the metastatic cervical lymphnodes. Lymphokine activated killer (LAK) activity in peripheral blood in administration of IL-2 showed a significant high of 13.2% at effector/target (E/T) ratio 13 compared with non-administration of IL-2 showed 4.3%. LAK activity in cervical non-metastatic lymphnodes in 6 cases of administration of IL-2 showed a significant high of 23.0% at E/T ratio 50 compared with 3 cases of non-administration of IL-2 which showed 3.7%. In the 2 evaluable courses given in patients a partial response was obtained in one case.
Department of Otolaryngology, Hyogo College of Medicine.
H
H
Ogasawara
N
N
Takeda
N
N
Takeda
T
T
Kumoi
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D004341:Drug Evaluation; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D007376:Interleukin-2; D011994:Recombinant Proteins