Stereometabolism of styrene in man: gas chromatographic determination of phenylethyleneglycol enantiomers and phenylethanol isomers in the urine of occupationally-exposed persons.
A gas chromatographic procedure for the determination of phenylethyleneglycol enantiomers and phenylethanol isomers is described and applied to the investigation of urine samples from occupationally styrene-exposed workers (11 males, six females) and an unexposed control group. Phenylethyleneglycol enantiomers and 2-phenylethanol were present in the urine samples of exposed and unexposed individuals whereas 1-DL-phenylethanol was not found in control urine. The L/D enantiomer ratio of phenylethyleneglycol was found to be approximately 3 in the exposed group and 1.5 in the control group. Because of the close structural relation of these metabolites to the primarily formed epoxide, the results give further insight into the stereotoxicity of styrene in man.
Korn
M
M
Wodarz
R
R
Drysch
K
K
Schoknecht
W
W
Schmahl
F W
FW
D000818:Animals; D002849:Chromatography, Gas; D004781:Environmental Exposure; D000431:Ethanol / Q000031:analogs & derivatives*; D005026:Ethylene Glycols / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009790:Occupations; D010626:Phenylethyl Alcohol / Q000652:urine*; D051381:Rats; D013237:Stereoisomerism; D020058:Styrene; D013343:Styrenes / Q000378:metabolism* / Q000633:toxicity
D005026:Ethylene Glycols; D013343:Styrenes; C031474:styrene glycol; D000431:Ethanol; D020058:Styrene; D010626:Phenylethyl Alcohol