Pulmonary clearance of inhaled 99Tcm-DTPA: significance of site of aerosol deposition.
The aim of this study was to analyse how changes in the site of 99Tcm-DTPA aerosol deposition between central and peripheral parts of the lung influence routine measurement of pulmonary clearance of 99Tcm-DTPA (PCl). The study was performed in six 'never-smokers' and 10 smokers with bronchial hypersecretion. Changes in aerosol deposition was accomplished by changing the aerosol particle size and the velocity by which the subjects inhaled the particles. In the smokers with bronchial hypersecretion there was a significantly smaller PCl after central deposition (P less than 0.01), than after peripheral deposition, while in the never-smokers, significance was not reached. The smokers with bronchial hypersecretion had a significantly higher PCl than the never-smokers (P less than 0.01) when the 99Tcm-DTPA had been deposited in the peripheral parts of the lung, but at the examination of central deposition, the difference was no longer significant. It is concluded that in smokers with bronchial hypersecretion measurement of regional PCl is influenced by the site of 99Tcm-DTPA deposition in the lung.
Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark.
S
S
Groth
F
F
Hermansen
N
N
Rossing
D000328:Adult; D000336:Aerosols; D000368:Aged; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000493:pharmacokinetics; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests; D012907:Smoking / Q000503:physiopathology*; D016284:Technetium Tc 99m Pentetate
D000336:Aerosols; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate