Ceftazidime in treatment of urinary tract infection in patients with spinal cord injury: comparison with moxalactam.
Ceftazidime was compared with moxalactam in the treatment of urinary tract infections in patients with spinal cord injury. Patients received ceftazidime or moxalactam, 500 mg twice daily for five days. Urine specimens were collected by urethral catheter. Adequate follow-up was obtained in 26 patients treated with ceftazidime and 13 patients treated with moxalactam. The infecting bacteria were not cultured in significant numbers from the urine of any patients after two to four days of antibiotics, except for 1 patient who had Pseudomonas aeruginosa persisting in the urine while receiving ceftazidime. At five to nine days after completing antibiotic therapy, the cure rate was 42 percent for ceftazidime and 15 percent for moxalactam. The rate of reinfection was significantly lower in the ceftazidime group than the moxalactam group.
Department of Urology/Surgery, University of Southern California School of Medicine, Los Angeles.
J Z
JZ
Montgomerie
D S
DS
Gilmore
H N
HN
Canawati
J W
JW
Morrow
D000328:Adult; D002442:Ceftazidime / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009070:Moxalactam / Q000627:therapeutic use*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D013119:Spinal Cord Injuries / Q000150:complications*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology
D002442:Ceftazidime; D009070:Moxalactam