Effect of glycerol on the hemodynamics of acutely induced ischemic area in the cerebral cortex of cats.
The effect of glycerol on the hemodynamics of ischemic areas of the brain was examined. Employing a photoelectric apparatus, the CBV (vol%), mean transit time of blood(s), and CBF (ml/100 g/min) in the cortex of the left ectosylvian gyrus were determined in 16 anesthetized cats before, at 1 hr, and at 2 hr after left MCA occlusion. In 10 cats, 10% glycerol in 5% fructose saline was intravenously administered at a speed of 5 ml/kg/hr at 1 hr after MCA occlusion. The other animals served as the control. In the group given glycerol, the relation between the values of CBF at 1 hr after MCA occlusion (X) and those at 2 hr after MCA occlusion (Y) was curvilinear and could be expressed by the regression curve, Y = 0.04X2 - 0.26X + 7.68 (R2 = 0.86). In the control group without glycerol, however, a linear relation expressed by the equation, Y = 0.76X + 5.96 (R2 = 0.94), was obtained. Comparison between the two relations indicated that glycerol improved the hemodynamics in the mild ischemic area with a relatively higher CBF. Severely ischemic areas showed no improvement.
Department of Neurology, Keio University, School of Medicine, Tokyo, Japan.
K
K
Ohta
F
F
Gotoh
M
M
Tomita
N
N
Tanahashi
M
M
Kobari
T
T
Shinohara
Y
Y
Terayama
B
B
Mihara
D000818:Animals; D001929:Brain Edema / Q000517:prevention & control*; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000627:therapeutic use; D005990:Glycerol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male
D005632:Fructose; D005990:Glycerol