Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production.
Two purine immunoenhancing drugs, isoprinosine and NPT 15392, were evaluated as inducers of IL-2 or enhancers of IL-2 induction by phytohemagglutinin (PHA). Both drugs were found to have significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations. Alone they were unable to consistently induce IL-2 activity. NPT 15392 was able to enhance PHA-induced IL-2 production at 10-100 times lower concentrations than isoprinosine. The actions of these compounds to enhance IL-2 production may explain their effects on PHA-induced lymphocyte proliferation.
Wiranowska-Stewart
M
M
Hadden
J W
JW
D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007042:Hypoxanthines / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology
D007042:Hypoxanthines; D007376:Interleukin-2; D010835:Phytohemagglutinins; D007288:Inosine; C026533:NPT 15392; D007542:Inosine Pranobex; D007213:Indomethacin