Analytical study of open four compartment pharmacokinetic models: concentrations, area under curves, mean residence times.
The analytical expressions for drug concentrations in each of the four compartments of different pharmacokinetic models, following any type of drug administration, are obtained from the transfer and elimination coefficients. In addition, areas under concentration curves and mean residence time of the drug, in a given compartment or in the whole system, are derived.
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
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Plusquellec
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Houin
D000284:Administration, Oral; D001682:Biological Availability; D007262:Infusions, Intravenous; D008954:Models, Biological; D010599:Pharmacokinetics