Treatment with GM1 ganglioside increases rat spinal cord indole content.
Chronic treatment with GM1 ganglioside apparently increases serotonin metabolism in the spinal cord of control and hemitransected rats. Dopamine metabolism is stimulated below a hemitransection with GM1 treatment. These observations are consistent with reports that GM1 promotes regrowth of neurons after experimental lesions of brain.
Hadjiconstantinou
M
M
Neff
N H
NH
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007211:Indoles / Q000032:analysis*; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013116:Spinal Cord / Q000187:drug effects*
D001679:Biogenic Amines; D007211:Indoles; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D005677:G(M1) Ganglioside; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine