Hormonal modulation of pineal melatonin synthesis in rats and Syrian hamsters: effects of streptozotocin-induced diabetes and insulin injections.
Pineal levels of tryptophan, 5-hydroxytryptophan, serotonin, N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid and the enzyme activities of N-acetyltransferase and hydroxyindole-O-methyltransferase were determined in male albino rats and Syrian hamsters that were injected with insulin twice daily for three days, or injected with streptozotocin to induce diabetes. Neither insulin injections nor streptozotocin diabetes had any effect on pineal melatonin production in rats. In hamsters, diabetes reduced the nocturnal peak of pineal melatonin content by approximately one half, while insulin injections had no effect on pineal melatonin levels; however, insulin injections did cause a slight increase in pineal N-acetyltransferase activity. These findings indicate that the pineal gland of the hamster may be more sensitive to alterations in plasma insulin levels than the same organ in rats.
T H
TH
Champney
A P
AP
Holtorf
C M
CM
Craft
R J
RJ
Reiter
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D008647:Mesocricetus; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism; D013045:Species Specificity; D014364:Tryptophan / Q000378:metabolism
D007328:Insulin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D000121:Acetylserotonin O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin; C006389:N-acetylserotonin