Expression of c-myc gene in human hepatoma.
The level of c-myc transcript was examined in liver samples from seven hepatoma patients. Transcripts were detected in all the normal liver parts examined; in contrast, in two hepatoma parts, there was a dramatic reduction in c-myc transcripts. The restriction enzyme pattern of c-myc gene appeared the same among samples. The data suggest that c-myc gene expression might not be required for the maintenance of the tumor state in human liver carcinogenesis.
Su
T S
TS
Lin
L H
LH
Lui
W Y
WY
Chang
C M
CM
Chou
C K
CK
Ting
L P
LP
Hu
C P
CP
Han
S H
SH
P'eng
F K
FK
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012313:RNA / Q000032:analysis; D014158:Transcription, Genetic
D012313:RNA; D004247:DNA; D004262:DNA Restriction Enzymes