[Effects of repeated chair restraint on physiological values in the rhesus monkey (Macaca mulatta)].
The purpose of this study was to examine the effects of repeated chair restraint on some physiological values in the rhesus monkey. Although heart rate and blood pressure increased significantly at the onset of chair restraint, these increased values gradually decreased with repetition of restraint as well as with the lapse of time after restraining. Finally, no elevation of these levels was detected after repetitions lasting eight hours per day for five days. Plasma cortisol, CK and GOT values also showed similar trends. These elevated physiological values at the onset of chair restraint seemed to be due to high sympathetic tone and muscular activity used to try to avoid the restraint. It is concluded that repeated chair restraint has an accommodative component in monkeys resulting in the return of some elevated physiological values to the normal level.
Drug Development Laboratories, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
T
T
Tatsumi
M
M
Koto
H
H
Komatsu
J
J
Adachi
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008251:Macaca / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D012149:Restraint, Physical / Q000009:adverse effects*
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D006854:Hydrocortisone