Anthelmintic profile of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate in experimental helminthiases.
Biological evaluation of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate against Ancylostoma ceylanicum, Nippostrongylus brasiliensis, Syphacia obvelata, Hymenolepis nana, H. diminuta and Cysticercus fasciolaris in experimental animals is reported. The compound (mg/kg) causes 100% elimination of A. ceylanicum (25 x 1), N. brasiliensis (100 x 1), S. obvelata (50 x 1), H. nana (250 x 3) and C. fasciolaris (50 x 10). It was also effective against the developing larvae (L3, L4 and L5) of A. ceylanicum at a single oral dose of 100 mg/kg. Another study indicated that the compound elicits 100% response within 32 hr of drug administration. The drug is well tolerated and LD50 is greater than 4500 mg/kg.
Gupta
S
S
Parasitology Division, Central Drug Research Institute, Lucknow, India.
Khan
A M
AM
Jain
M K
MK
Katiyar
J C
JC
Naim
S S
SS
Singh
S K
SK
Sharma
S
S
D000818:Animals; D000871:Anthelmintics; D001562:Benzimidazoles / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006373:Helminthiasis / Q000188:drug therapy; D007928:Lethal Dose 50; D015394:Molecular Structure; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity
D000871:Anthelmintics; D001562:Benzimidazoles; D010880:Piperidines; C065812:methyl 5(6)-(4-methylpiperidin-1-yl)carbonylbenzimidazole-2-carbamate