In vivo effects of follicle-stimulating hormone on testicular macrophages.
The effect of an intraperitoneal injection of various hormones on the incorporation of amino acids and uridine into acid-precipitable material by subsequently isolated testicular macrophages was investigated. It was found that treatment with follicle-stimulating hormone (FSH), but not luteinizing hormone (LH) or insulin, significantly increased incorporation of amino acids into secreted (but not cellular) protein and uridine incorporation into cellular RNA in a dose-dependent manner. Maximal responsiveness was observed at a dose of 50 micrograms of the hormone. These studies demonstrate that FSH has an action on testicular macrophages in vivo.
J B
JB
Yee
J C
JC
Hutson
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D007700:Kinetics; D007986:Luteinizing Hormone / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013737:Testis / Q000166:cytology*; D014529:Uridine / Q000378:metabolism
D000596:Amino Acids; D011506:Proteins; D012313:RNA; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D014529:Uridine