Morphology of experimental tumors of the sympathetic nervous system.
The morphology of experimental tumors of the sympathetic nervous system in rabbits and hamsters induced by administration of nitrose compounds and the use of modifying factors were studied. The tumors were localized in the mediastinum, retroperitoneal space, adrenals and kidneys. A predominant involvement of the female animals was observed. Histological, histochemical and electron microscopic studies of 33 tumors of the sympathetic nervous system were carried out. By their degree of maturity the tumors were classified as ganglioneuromas, ganglioneuroblastomas and neuroblastomas. By their structure the experimental tumors were similar to the analogous neoplasias of man.
Experimental Oncology Department, Georgian SSR Ministry of Health, Tbilissi.
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Beniashvili
D000818:Animals; D006224:Cricetinae; D005038:Ethylnitrosourea; D005260:Female; D005729:Ganglioneuroma / Q000139:chemically induced / Q000648:ultrastructure*; D008647:Mesocricetus; D008770:Methylnitrosourea; D008854:Microscopy, Electron; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D009447:Neuroblastoma / Q000139:chemically induced / Q000648:ultrastructure*; D011817:Rabbits; D012737:Sex Factors; D013564:Sympathetic Nervous System
D008770:Methylnitrosourea; D005038:Ethylnitrosourea