Norepinephrine-induced intracellular Ca2+ release from vascular smooth muscle.
In rabbit aorta and superior mesenteric artery, application of NE causes release of Ca2+ from an intracellular Ca2+ store, probably SR. The amount of released Ca2+ is sufficient to activate the myofilaments submaximally. It is suggested that NE mediates Ca2+ release by a rapid increase in the free Ca2+ concentration near the SR (Ca2+-induced Ca2+ release). The uptake of Ca2+ into the store and the Ca2+-induced Ca2+ release is modulated by c-AMP.
P
P
Leijten
K
K
Saida
C
C
van Breemen
D000818:Animals; D001011:Aorta; D002118:Calcium / Q000378:metabolism*; D002451:Cell Compartmentation / Q000187:drug effects; D003593:Cytoplasm / Q000378:metabolism; D066298:In Vitro Techniques; D008638:Mesenteric Arteries; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D002118:Calcium; D009638:Norepinephrine