Suspension polymerization of 2-hydroxyethyl methacrylate in the presence of polymeric diluents: a novel route to spherical highly porous beads for biomedical applications.
Spherical, highly porous beads of poly(2-hydroxyethyl methacrylate) (PHEMA) cross-linked with ethylene glycol dimethacrylate (EGDM) were prepared by suspension polymerization of HEMA in concentrated NaCl solutions in presence of toluene, poly(methyl methacrylate) (PMMA) in toluene, and poly(tetramethylene glycol) (PTMG). Magnesium hydroxide prepared in situ in the dispersion medium gave the best stabilization effect for the monomer droplets. In the presence of PTMG, beads having nearly 1.0 mm in diameter could be prepared, while toluene alone as the diluent produced beads of very small size. Removal of PMMA or PTMG from the beads after polymerization using suitable solvents gave rise to highly porous PHEMA microspsheres. Polymerization in the presence of PTMG produced microspsheres with better spherical geometry as compared to those generated in the presence of PMMA. The effect of various factors such as NaCl concentration, concentration of Mg(OH)2, and the concentration of PMMA or PTMG in the monomer phase on the stability of the suspension and the particle size distribution was investigated.
Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
A
A
Jayakrishnan
B C
BC
Thanoo
D003432:Cross-Linking Reagents; D004355:Drug Stability; D006018:Glycols; D007202:Indicators and Reagents; D008689:Methacrylates; D008768:Methylmethacrylates; D008863:Microspheres; D010316:Particle Size; D011102:Polyhydroxyethyl Methacrylate / Q000138:chemical synthesis*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis*; D013499:Surface Properties
D003432:Cross-Linking Reagents; D006018:Glycols; D007202:Indicators and Reagents; D008689:Methacrylates; D008768:Methylmethacrylates; D011109:Polymethacrylic Acids; C047554:polytetramethylene glycol; D011102:Polyhydroxyethyl Methacrylate; C004919:ethylene dimethacrylate