Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy.
The radiobiological parameters of 33 tumor cell lines were studied in biopsy samples obtained from patients prior to radiotherapy. Epithelial tumor cells derived from head and neck cancer patients were more radioresistant than tumor cell lines derived from patients with sarcoma regardless of method of analysis. The presence of radioresistant tumor cell lines was associated with local failure in some patients. However, the presence of radiosensitive tumor cells did not necessarily predict local control. Our data suggest radiocurability is complex and inherent radiobiological parameters of tumor cells may be only one factor in radiotherapy outcome.
Department of Radiation and Cellular Oncology, Michael Reese/University of Chicago Center for Radiation Therapy, Chicago, IL.
R R
RR
Weichselbaum
M A
MA
Beckett
S
S
Vijayakumar
M A
MA
Simon
A M
AM
Awan
J
J
Nachman
W R
WR
Panje
M E
ME
Goldman
A G
AG
Tybor
W J
WJ
Moran
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D066298:In Vitro Techniques; D011836:Radiation Tolerance; D012509:Sarcoma / Q000473:pathology* / Q000532:radiotherapy