Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats.
Bleomycin is an antineoplastic agent that causes a dose-related lung fibrosis that limits its therapeutic effectiveness. It has been proposed that the cellular toxicity and antitumor effects of bleomycin occur by formation of O2-Fe(II)-bleomycin complexes that degrade DNA and release O2- and OH radicals that attack other cellular components. Twice daily injections of the iron chelator deferoxamine were utilized in an attempt to ameliorate bleomycin-induced lung fibrosis. They failed to diminish bleomycin-induced lung inflammation and fibrosis in rats.
Cross
C E
CE
Warren
D
D
Gerriets
J E
JE
Wilson
D W
DW
Halliwell
B
B
Last
J A
JA
D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D003094:Collagen / Q000032:analysis; D003676:Deferoxamine / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains
D001761:Bleomycin; D003094:Collagen; D003676:Deferoxamine