On the mechanism of enhanced release of [14C]glutamate in hippocampal long-term potentiation.
K+-induced release of [14C]glutamate was studied in slices of dentate gyrus prepared from control rats and rats in which long-term potentiation (LTP) had been induced in vivo. At all concentrations of Ca2+ studied, release from potentiated slices was greater than from control slices. In the same preparations both Ruthenium Red and caffeine enhanced basal release but in potentiated tissue the Ruthenium Red-induced release was significantly greater than in control tissue. These results are discussed in the light of our recent finding that enhanced transmitter release is associated with LTP.
Lynch
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D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D004558:Electric Stimulation; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009940:Organoids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012430:Ruthenium Red / Q000494:pharmacology; D009435:Synaptic Transmission
D005971:Glutamates; D012430:Ruthenium Red; D002110:Caffeine; D018698:Glutamic Acid; D002118:Calcium