Serological and immunochemical specificity of a human autoanti-Gerbich-like antibody.
An 85-year-old male with cardiac failure secondary to anaemia had an apparent anti-Ge2 (Ge = Gerbich) in his serum which did not agglutinate his own red cells even though they were Ge-positive in tests with alloanti-Ge. The direct antiglobulin test was negative; however, an antibody with apparent anti-Ge2 specificity was eluted from his red cells. The patient's autoantibody was shown in immunoblotting experiments to react with an antigenic determinant on beta-sialoglycoprotein. This case illustrates that an autoanti-Ge can masquerade as an alloantibody, thereby complicating antibody identification, and implies that the immunochemical specificity of autoanti-Ge2 is different from that of alloanti-Ge2.
Blood Group Reference Laboratory, Bristol, UK.
J
J
Poole
M E
ME
Reid
J
J
Banks
Y W
YW
Liew
J
J
Addy
G
G
Longster
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications* / Q000276:immunology / Q000628:therapy; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001803:Blood Transfusion; D002303:Cardiac Output, Low / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008297:Male
D001323:Autoantibodies; D007518:Isoantibodies