Cytogenetic study of a case of childhood erythroleukemia.
We report a case of childhood erythroleukemia diagnosed by French-American-British Cooperative group (FAB) and by cytogenetic analysis of bone marrow cells. The following major chromosome anomalies were detected: hyperdiploidy with a modal number of 49, three markers consisting of translocations between chromosomes 3, 9, 20, and 15, deletion of the long arm of chromosome 16 (q22----qter), and karyotype instability. These changes were compared with others reported in the literature and discussed in terms of their importance for diagnostic confirmation.
Duarte
M H
MH
Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Tone
L G
LG
Soares
L R
LR
dos Santos
S A
SA
D001853:Bone Marrow / Q000648:ultrastructure; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D008297:Male
D005819:Genetic Markers