Interaction between sodium channels in mouse neuroblastoma cells.
Single sodium channels in mouse neuroblastoma cells (N1E 115) were studied in cell-attached patches. During a series of consecutive responses to depolarizing pulses, records with and without channel opening were seen to form clusters rather than appearing randomly. The probability of finding open channels on a record seemed to increase with increasing number of channel openings. The open times of channels became shorter with increasing closed time interval measured between consecutive channel openings. Overlapping openings showed a voltage-dependent open time, in contrast to single openings which had voltage-independent open time. On the basis of these observations interaction between neighbouring sodium channels is suggested.
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D000818:Animals; D002460:Cell Line; D007473:Ion Channels / Q000378:metabolism* / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D012964:Sodium