Photoreceptor cell-specific localization of S-antigen in retina.
Retinal S-antigen has been found to be localized in a specific photoreceptor cell population of squirrel (Tamias striatus) and rhesus monkey retina. In these cone-rich retinas S-antigen seems only to be present in the rods. Differential immunofluorescent staining of the photoreceptor cells was accomplished by using monospecific rabbit-anti bovine S-antigen antiserum, which exhibits very limited species specificity. In view of its co-localization with rhodopsin in rods and considering data from literature, we suggest that S-antigen is a major component of the phototransduction system in these cells.
R M
RM
Broekhuyse
H J
HJ
Winkens
D000818:Animals; D000941:Antigens / Q000032:analysis*; D019393:Arrestin; D000939:Epitopes / Q000032:analysis; D005455:Fluorescent Antibody Technique; D008253:Macaca mulatta; D010786:Photoreceptor Cells / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000276:immunology*; D012243:Rhodopsin / Q000378:metabolism; D012589:Sciuridae
D000941:Antigens; D019393:Arrestin; D000939:Epitopes; D012243:Rhodopsin