Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan.
5-Hydroxyindoleacetic acid (5-HIAA) and cortisol in cerebrospinal fluid (CSF), response of the dexamethasone suppression test (DST) and the clinical response to treatment with 5-hydroxytryptophan (5-HTp) plus carbidopa were studied in a group of 21 depressed inpatients (major depression with melancholia) in order to correlate biological findings with psychopathologicalones. A positive correlation was found between strong suicidal thoughts, suicidal attempts and self-aggressivity and low concentration of 5-HIAA in CSF and a less significant but still positive correlation with abnormal DST response and with clinical response to the treatment.
López-Ibor
J J
JJ
Saiz-Ruiz
J
J
Pérez de los Cobos
J C
JC
D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000328:Adult; D000374:Aggression / Q000502:physiology*; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000503:physiopathology; D002230:Carbidopa / Q000627:therapeutic use; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000503:physiopathology; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D012652:Self Mutilation / Q000503:physiopathology; D013406:Suicide, Attempted
D006897:Hydroxyindoleacetic Acid; D003907:Dexamethasone; D006916:5-Hydroxytryptophan; D002230:Carbidopa; D006854:Hydrocortisone