[Antigenic relation between thyroid peroxidase and the microsomal antigen implicated in auto-immune diseases of the thyroid].
Pools of sera from patients with Graves' disease or Hashimoto's thyroiditis highly inhibit the binding to human thyroid membranes of one of 19 monoclonal antibodies raised against preparations of human thyroid membranes. This monoclonal antibody reacts with human and bovine thyroid peroxidase and bovine lactoperoxidase but not with human hemoglobin, cytochrome c and other related molecules. These results indicate that the thyroid peroxidase and the microsomal antigen are antigenically related. These data taken together with those from other groups, highly suggest that thyroid peroxidase is the microsomal antigen involved in autoimmune thyroid diseases.
B
B
Czarnocka
J
J
Ruf
M
M
Ferrand
P
P
Carayon
D000328:Adult; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D001323:Autoantibodies; D000939:Epitopes / Q000032:analysis; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D008861:Microsomes / Q000276:immunology*; D010544:Peroxidases / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens; D001323:Autoantibodies; D000939:Epitopes; D010544:Peroxidases
Parenté antigénique entre la peroxydase thyroïdienne et l'antigène microsomal impliqué dans les affections auto-immunes de la thyroïde.