CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases.
We have previously shown that a major granule-associated cationic protein CAP 37 (Mr = 37 kD) derived from human PMN is a monocyte-specific chemoattractant. The N-terminal amino acid sequence of this novel chemotactic protein shares significant homology with a number of inflammatory molecules with protease activity including elastase and cathepsin G. However, a critical substitution of a serine for a histidine at position 41, results in its lack of serine protease activity.
Dept. of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.
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Pereira
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Spitznagel
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Pohl
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Wilson
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Morgan
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Palings
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Larrick
D000595:Amino Acid Sequence; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D002352:Carrier Proteins; D006801:Humans; D007249:Inflammation; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009504:Neutrophils / Q000502:physiology*; D010447:Peptide Hydrolases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
C062991:AZU1 protein, human; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D002352:Carrier Proteins; D010447:Peptide Hydrolases