Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.
A near full-length cDNA encoding the human vitamin D-binding protein (hDBP) was isolated from a human liver mRNA expression library. Complete sequence analysis of this clone predicts the full-length amino acid sequence of the pre-hDBP. Comparison of the sequence of the hDBP mRNA and protein to existing protein and nucleic acid data banks demonstrates a strong and highly characteristic homology of the hDBP with human albumin (hALB) and human alpha-fetoprotein (hAFP). Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family.
Cooke
N E
NE
David
E V
EV
D000595:Amino Acid Sequence; D001483:Base Sequence; D003545:Cysteine; D004247:DNA / Q000235:genetics; D006801:Humans; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D012709:Serum Albumin / Q000235:genetics; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D000509:alpha-Fetoproteins / Q000235:genetics
D012709:Serum Albumin; D014809:Vitamin D-Binding Protein; D000509:alpha-Fetoproteins; D004247:DNA; D003545:Cysteine