Transcortin and alpha 2u-globulin messenger RNA activities during turpentine-induced inflammation in the rat.
Previously we have shown that the serum concentration of transcortin and alpha 2u-globulin markedly decreases during turpentine-induced inflammation. In the present study transcortin and alpha 2u-globulin mRNA from healthy rats and from animals with inflammation was translated in a rabbit reticulocyte lysate system. Female rats had higher levels of translatable transcortin mRNA than male animals and the level of mRNA for transcortin and alpha 2u-globulin decreased rapidly during inflammation. These results indicate that the sex difference in the serum level of transcortin and the changes in serum transcortin and alpha 2u-globulin during inflammation are mainly determined by differences in the mRNAs in the liver.
D
D
Faict
G
G
Verhoeven
B
B
Mertens
P
P
De Moor
D000510:Alpha-Globulins / Q000235:genetics*; D000818:Animals; D011232:Chemical Precipitation; D005260:Female; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D014156:Transcortin / Q000235:genetics*; D014425:Turpentine / Q000494:pharmacology*
D000510:Alpha-Globulins; D012333:RNA, Messenger; C013803:alpha 2u globulin; D014156:Transcortin; D014425:Turpentine