[Decreased levels of the albumin-alpha-1-globulin fraction of serum proteins, risk factor for ischemic cardiopathy].
Serum proteins and their electrophoretic fractions: albumin-alpha-1 globulin (Alb-alpha-1), alpha-2 and alpha-3 globulins, beta and gamma globulins have been included in the Paris Prospective Study which has concerned 7434 middle-aged men free of any atherosclerotic disease at entry and followed-up during 6.6 years on average. The level of Alb-alpha-1 is significantly lower among myocardial infarction or sudden death cases: the mean difference with controls is equal to one gram. The inverse relationship between incidence and Alb-alpha-1 level is a continuous one. No relationship is observed with angina. In multivariate analysis, serum cholesterol, blood pressure, tobacco and Alb-alpha-1 (negative relationship) are significantly associated with grave coronary heart disease. The relationship with Alb-alpha-1 is independent of the hematocrit. Possible pathogenic mechanisms are discussed.
Richard
J L
JL
Warnet
J M
JM
Ducimetière
P
P
D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis*; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010297:Paris; D011446:Prospective Studies; D012306:Risk; D012709:Serum Albumin / Q000032:analysis*; D012907:Smoking
D000510:Alpha-Globulins; D012709:Serum Albumin; D002784:Cholesterol
La baisse du taux de la fraction albumine-alpha-1 globuline des protéines sériques, facteur de risque des cardiopathies ischémiques.