[Inhibition of Na+, K+-ATPase activity by sodium channel blockers].
Blocking agent of sodium channels in membranes of epithelial cells amiloride and triamterene as well as tetrodotoxin, which blocked sodium channels in electroexcitable membranes, were found to be effective inhibitors of Na, K-ATPase. A similarity between sodium sites of sodium channels and that of Na, K-ATPase is considered.
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D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D007672:Kidney Cortex / Q000201:enzymology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013779:Tetrodotoxin / Q000494:pharmacology; D014223:Triamterene / Q000494:pharmacology
D007473:Ion Channels; D013779:Tetrodotoxin; D000584:Amiloride; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D014223:Triamterene
Ugnetenie aktivnosti Na+, K+-ATFazy blokatorami natrievykh kanalov.