Distribution of serum zinc between albumin and alpha 2-macroglobulin in patients with different zinc metabolic disorders.
The distribution of total serum zinc between serum albumin and alpha 2-macroglobulin was evaluated by ultracentrifugation in patients with cirrhosis of the liver, insulin-dependent diabetes mellitus, or chronic renal failure. We found that the alpha 2-macroglobulin bound zinc fraction amounts to approximately 6 and 5% of the total serum zinc in patients with cirrhosis of the liver and diabetes mellitus, which corresponds to the distribution in controls. In patients with chronic renal failure, however, the alpha 2-macroglobulin-bound zinc fraction only constitutes approximately 2%, which is significantly less than in controls. Our findings indicate that most of the total serum zinc is bound to serum albumin.
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Kiilerich
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Christiansen
D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D015032:Zinc / Q000097:blood*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D012709:Serum Albumin; D000511:alpha-Macroglobulins; D015032:Zinc