Lack of detectable reverse transcriptase activity in human and chimpanzee sera with a high infectivity for non-A, non-B hepatitis.
A serum sample from a patient with hepatitis and samples from two experimentally infected chimpanzees, all with a high infectivity for non-A, non-B hepatitis, were tested for reverse transcriptase. Biopsy confirmed that the hepatocytes of the chimpanzees that received these sera contained the characteristic tubular structures associated with non-A, non-B hepatitis. None of these three sera revealed detectable enzyme activity. We have not been able to confirm the association of reverse transcriptase activity with non-A, non-B hepatitis reported recently.
Itoh
Y
Y
Iwakiri
S
S
Kitajima
K
K
Gotanda
T
T
Miyaki
M
M
Miyakawa
Y
Y
Mayumi
M
M
D000818:Animals; D006526:Hepatitis C / Q000201:enzymology* / Q000382:microbiology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000473:pathology; D002679:Pan troglodytes; D012194:RNA-Directed DNA Polymerase / Q000097:blood*
D012194:RNA-Directed DNA Polymerase