Lipids of normal and osteochondritic cartilage of the immature canine humeral head.
Specimens of cartilage removed from the shoulder joint of dogs with osteochondritis dissecans were compared with the articular-epiphyseal cartilage from the same location of healthy dogs. The pathologic cartilage lost the lamination pattern of articular-epiphyseal cartilage from healthy dogs. Chondrocytes of healthy and pathologic cartilage contained lipid inclusions. However, in pathologic samples, the lipid inclusions were more prominent, particularly in the superficial region of the presumptive articular cartilage. Lipids in the interterritorial matrix of the pathologic cartilage were observed. The pathologic cartilage contained large groups of chondrocytes and areas of mineralization of variable magnitude. Although lipid inclusions were found in the chondrocytes of cartilage of healthy dogs, the increase in magnitude of lipids in the cartilage from dogs with osteochondritis dissecans was considered to result from a metabolic response of the chondrocyte to an altered microenvironment. The loss of sudanophilic lipids in areas of chondrolysis may be used to explain the retardation of osteogenesis of chondrolytic cartilage.
S A
SA
Kincaid
R G
RG
Rudd
S A
SA
Evander
D000818:Animals; D002358:Cartilage, Articular / Q000033:anatomy & histology* / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs / Q000033:anatomy & histology*; D006811:Humerus / Q000033:anatomy & histology* / Q000473:pathology; D002479:Inclusion Bodies; D008055:Lipids / Q000032:analysis; D010007:Osteochondritis / Q000662:veterinary*; D010008:Osteochondritis Dissecans / Q000473:pathology / Q000662:veterinary*; D013194:Staining and Labeling
D008055:Lipids