[Characteristics of the DNA-RNA-protein-synthesizing apparatus of cerebral cortex neurons as a result of prenatal exposure to alcohol].
Ribonucleoproteins and chromatin of the nuclei were studied by the electron--cytochemical method proposed by Bernhard while the incorporation of 3H-leucine into the proteins of pyramidal neurons of layer V of the sensomotor cortex of the brain was investigated histoautoradiographically. An elevated metabolic activity of the DNA-RNA protein system was found in neurons of 30-day-old rats that had been exposed to alcohol in the antenatal period. In animals over 2 months of age, these parameters became normal. The results may be considered as a reflection of a transient delay of the development of cortical neurons.
N S
NS
Kolomeets
P B
PB
Kazakova
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism*; D006651:Histocytochemistry; D007930:Leucine / Q000378:metabolism; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012261:Ribonucleoproteins / Q000378:metabolism
D002843:Chromatin; D009419:Nerve Tissue Proteins; D012261:Ribonucleoproteins; D012313:RNA; D004247:DNA; D007930:Leucine
Kharakteristika DNK-RNK-beloksinteziruiushchego apparata korkovykh neĭronov golovnogo mozga pri antenatal'nom vozdeĭstvii alkogolia.