The effect of insulin on the central serotonergic system of the rat.
Single administration of insulin (1-3 U/kg) caused an increased response of rats to 5-methoxytryptamine (head shakes), 4 but not 16 h after the injection. Multiple insulin injections caused a dose and time-related increase in the number of head shakes. The effect was observed up to 24 h after the last insulin dose. Insulin (2 U/kg given for 3-14 days) caused an increase in the cerebral concentration of 5-hydroxyindoleacetic acid (5-HIAA) and accelerated the cerebral serotonin (5-HT) turnover. The 5-HIAA concentration was approx. twice as high as in the controls, regardless of the duration of the treatment; the degree of 5-HT turnover acceleration did not depend on the duration of the treatment, either, and was observed up to 14 days after cessation of insulin administration.
Juszkiewicz
M
M
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D012701:Serotonin; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid