The effect of venous obstruction in infected pedicle flap.
A new model of soft-tissue infection is used to investigate the effect of the local wound environment on the septic focus. Island pedicle flaps were raised on the buttock of 24 adult ewes and multiply inoculated with Staphylococcus aureus. Flaps with bacterial inoculation, without compromise of venous outflow, showed distal necrosis (mean +/- SEM percent of surface area, 25.8% +/- 8.6%) and developed septic foci with bacterial counts one log less than the amount injected. Flaps with inoculation and venous outflow obstruction underwent subtotal necrosis (mean percent of surface area, 73.3% +/- 11.2%) and had counts two logs higher than the nonobstructed flaps but without discrete septic foci. Flaps without inoculation, with or without venous obstruction, survived completely. Venous outflow obstruction is shown herein to potentiate tissue necrosis by raising bacterial counts in a septic focus and preventing defensive abscess formation by the host.
Department of Surgery, State University of New York Health Science Center, Brooklyn.
R
R
Mann
L G
LG
Phillips
J P
JP
Heggers
H A
HA
Linares
L D
LD
Traber
M C
MC
Robson
D000818:Animals; D003250:Constriction; D005260:Female; D009336:Necrosis; D012039:Regional Blood Flow; D012756:Sheep; D013203:Staphylococcal Infections / Q000503:physiopathology; D013524:Surgical Flaps / Q000502:physiology*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000503:physiopathology*; D014680:Veins / Q000503:physiopathology*