Comparative chemotherapeutic activity of cefpirome and imipenem in experimental infections.
In systemic and local infections, the therapeutic efficacy of cefpirome was compared to that of imipenem and cefotaxime. Murine septicemia induced with methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains responded well to cefpirome and imipenem therapy, the ED50 values ranged from 0.8 to 28.40 mg/kg and 0.5 to 15.58 mg/kg, respectively. The carbapenem also displayed high efficacy against Enterococci and was more potent than cefpirome. Cefotaxime, however, exhibited lower activity or proved to be inactive against these strains. With ED50 values of 0.03 to 31.33 mg/kg, cefpirome was the most active of the three antibiotics in protecting mice challenged with Enterobacteriaceae. The corresponding ED50 values of imipenem and cefotaxime ranged from 0.72 to 70.95 mg/kg and 0.06 to 66.30 mg/kg, respectively. Despite distinctly lower in vitro activity against the infecting organism, cefpirome showed efficacy similar to imipenem in the treatment of subcutaneous S. aureus abscesses in mice. It was more effective than imipenem and cefotaxime against experimental Klebsiella pneumonia in mice and the Escherichia coli infected granuloma pouch in rats.
Hoechst AG, Pharma Research, Frankfurt/M., FRG.
N
N
Klesel
D
D
Isert
M
M
Limbert
A
A
Markus
G
G
Seibert
E
E
Schrinner
D000038:Abscess / Q000188:drug therapy; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D002439:Cefotaxime / Q000494:pharmacology / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D015378:Imipenem / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D008809:Mice, Inbred C3H; D011014:Pneumonia / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000188:drug therapy; D013207:Staphylococcal Skin Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy; D000097572:Cefpirome
D002439:Cefotaxime; D002511:Cephalosporins; D015378:Imipenem; D000097572:Cefpirome