Mode of action and indication for disodium cromoglycate (DSCG).
The possible mode of action for DSCG is described. It is assumed that DSCG has a cell specific effect on mast cells, smooth muscle cells, secretory cells and nerve endings. The main action is probably due to an influence upon the calcium channel opening receptors, thus preventing consecutive mediator release from these cells. The lack of efficacy in underlying diseases (rhinitis and bronchial asthma) is probably due to other pathophysiological mechanisms involved. The possible role of bradykinin as a potent mediator is discussed. The indication of DSCG is briefly summarized.
Kunkel
G
G
Baumer
F E
FE
Okuda
M
M
van Cauwenberge
P
P
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001986:Bronchial Spasm / Q000188:drug therapy / Q000503:physiopathology; D004205:Cromolyn Sodium / Q000494:pharmacology* / Q000627:therapeutic use; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D007705:Kinins / Q000502:physiology; D008407:Mast Cells / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats
D007473:Ion Channels; D007705:Kinins; D018377:Neurotransmitter Agents; D004205:Cromolyn Sodium