Association between rat serum cholinesterase and some phospholipid components of lipoproteins in thioacetamide-induced hepatic injury.
Rat serum lipoprotein phospholipids and serum cholinesterase activity in control and thioacetamide-treated rats (50 mg/kg/day for 30 days) were studied. Analyses were done after 1, 3, 8 and 30 intraperitoneal doses of thioacetamide or 0.15 mol/l NaCl. Cholinesterase activity significantly increased with thioacetamide treatment. Only two phospholipids: LDL-phosphatidylcholine and HDL-lysophosphatidylcholine appeared associated with cholinesterase activity. LDL-phosphatidylcholine increased through the action of hepatotoxic thioacetamide while HDL-lysophosphatidylcholine significantly decreased. Because of the high statistically significant association between changes in these lipoprotein phospholipids and in cholinesterase in this model of hepatic injury, we conclude that cholinesterase could be involved in the regulation of these phospholipid levels.
Human Nutrition Research Center on Aging-Tufts University, Boston, MA 02111.
J
J
Osada
H
H
Aylagas
B
B
Sánchez-Ramos
M J
MJ
Miró-Obradors
C
C
Arce
G
G
Cao
M T
MT
Mendez-Marco
E
E
Palacios-Alaiz
D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D002802:Cholinesterases / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008954:Models, Biological; D010713:Phosphatidylcholines / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013853:Thioacetamide / Q000633:toxicity*
D000081:Acetamides; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010713:Phosphatidylcholines; D013853:Thioacetamide; D002802:Cholinesterases