Chromosomal mapping of the murine c-abl proto-oncogene by in situ hybridization.
Deletion and rearrangement of chromosome 2 were shown to be major cytogenetic characteristics of radiation-induced murine myeloid leukemias. Analysis of the localization of the murine protooncogene c-abl, previously assigned by Goff et al. to chromosome 2, was done using the in situ hybridization method. The c-abl was located close to the centromere, within bands 2A-2B. This site does not correspond to the common characteristic deleted segments (2C-2D) predominantly observed in radiation induced murine myeloid leukemias.
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
L
L
Trakhtenbrot
Z
Z
Kelman
V
V
Rotter
N
N
Haran-Ghera
D000818:Animals; D002874:Chromosome Mapping; D051379:Mice; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016315:Proto-Oncogene Proteins c-abl; D011519:Proto-Oncogenes
D011518:Proto-Oncogene Proteins; D016315:Proto-Oncogene Proteins c-abl