Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats.
Administration of carbon tetrachloride to normal rats increased activities of hepatic 5(1)-nucleotidase, acid phosphatase, acid ribonuclease while the activities of succinate dehydrogenase, glucose 6-phosphatase, superoxide dismutase and cytochrome P450 were decreased. Levels of lipid peroxides, total lipids and cholesterol of liver were also increased. The activities of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alkaline phosphatase were increased. Other serum parameters showing changes after carbon tetrachloride were: bilirubin, proteins, cholesterol, triglycerides and lipoprotein-X. Picroliv (from the plant Picrorhiza kurroa) in doses of 6 and 12 mg/kg provided a significant protection against most of the biochemical alterations produced by carbon tetrachloride. The degree of protection afforded by picroliv, when administered simultaneously or as a pretreatment was almost equal.
Dwivedi
Y
Y
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies Central Drug Research Institute, Lucknow.
Rastogi
R
R
Chander
R
R
Sharma
S K
SK
Kapoor
N K
NK
Garg
N K
NK
Dhawan
B N
BN
D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D002934:Cinnamates / Q000494:pharmacology*; D004798:Enzymes / Q000097:blood / Q000378:metabolism; D006027:Glycosides / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D014641:Vanillic Acid / Q000494:pharmacology*
D002934:Cinnamates; D004798:Enzymes; D006027:Glycosides; D010936:Plant Extracts; C057463:kutkin; D002251:Carbon Tetrachloride; D014641:Vanillic Acid