Neuroendocrine changes in depression.
Biological research in depression has concentrated on 'endogenous' depressions and over the past 30 years has been guided by the amine theory. Neuroendocrine abnormalities in depression have been reported for over 20 years and include changes in the hypothalamic-pituitary-adrenal and thyroid axes, in growth hormone and prolactin secretion. As neurotransmitters regulate neuroendocrine secretion, inter-relationships between neurochemical and neuroendocrine abnormalities may provide a window for understanding the pathophysiology of depression. The availability of these biological markers for depression opens new possibilities for research in psychiatric diagnosis and for management.
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D001679:Biogenic Amines / Q000502:physiology; D003866:Depressive Disorder / Q000503:physiopathology*; D003907:Dexamethasone; D013006:Growth Hormone / Q000378:metabolism; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D009490:Neurosecretory Systems / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology; D013961:Thyroid Gland / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone
D001679:Biogenic Amines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D013006:Growth Hormone; D006854:Hydrocortisone; D006719:Homovanillic Acid