[Effect of pyridoxal-5-phosphate-modified polyhemoglobin on mammals' erythrocyte aggregation].
Human red blood cells in vitro are most subjected to aggregating action of pyridoxal-5'-phosphate-modified polyhemoglobin (PPPH) as compared to red blood cells of other mammals--mouse, dog, rabbit, rat. A conclusion has been made that the study of rheologic properties of PPPH in the animals cannot completely reflect the aggregating action of this oxygen-carrier in case of its infusion to humans.
Smirnov
I V
IV
Groznaia
T G
TG
Khachatur'ian
A A
AA
D000818:Animals; D001802:Blood Substitutes; D004285:Dogs; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D006454:Hemoglobins / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001802:Blood Substitutes; D006454:Hemoglobins; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate
Vliianie poligemoglobina, modofitsirovannogo piridoksal'-5-fosfatom, na agregatsiiu éritrotsitov mlekopitaiushchukh.