Platelet serotonin and blood tryptophan in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
The number of platelets and their content in serotonin (5-HT) were determined in 12-week-old spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) and in normotensive Wistar-Kyoto rats (WKY). Spontaneously hypertensive rats had 49% more platelets and a 65% higher platelet 5-HT circulating pool than SHRSP and WKY. An increased synthesis of 5-HT by enterochromaffin cells in SHR is suggested by the lower level of plasma total and albumin-bound tryptophan and by the higher free/bound tryptophan ratio found in those rats, as compared with WKY. In SHRSP, a decrease of platelet survival time was reported, associated to an increased platelet production. This would explain the absence of variation of platelet number and 5-HT content.
P
P
Guicheney
M
M
Baudouin-Legros
J P
JP
Garnier
P
P
Roques
C
C
Dreux
P
P
Meyer
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D003956:Dialysis; D006973:Hypertension / Q000097:blood*; D008297:Male; D010976:Platelet Count; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000097:blood*; D014364:Tryptophan / Q000097:blood*
D012701:Serotonin; D014364:Tryptophan