Nephrotoxicity of common drugs used by urologists.
Many clinically popular drugs, such as aminoglycoside antibiotics, amphotericin B, radiographic contrast media, analgesics, platinum-based cancer chemotherapy, and cyclosporine, can cause deterioration of kidney function even when the dose has been adjusted properly for renal insufficiency. The authors review the pathophysiologic mechanisms of nephrotoxicity of these drugs and prevention and treatment strategies.
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland.
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WM
Bennett
G A
GA
Porter
D000617:Aminoglycosides; D000666:Amphotericin B / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin; D002945:Cisplatin / Q000009:adverse effects; D003287:Contrast Media / Q000009:adverse effects*; D003524:Cyclosporins / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D009944:Organoplatinum Compounds / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D003287:Contrast Media; D003524:Cyclosporins; D009944:Organoplatinum Compounds; D000666:Amphotericin B; D016190:Carboplatin; D002945:Cisplatin