The metabolism of some xenobiotics in germ-free and conventional rats.
The different participation of the gastrointestinal microflora in the biotransformation of gamma-hexachlorcyclohexane (gamma-HCH), azobenzene and the isolated glucosinolate progoitrin was studied. Marked dehydrochlorination of gamma-HCH to gamma-pentachlorcyclohexene (PCCH) also occurs without participation of the microflora. Azobenzene was reduced in germ-free (g) and conventional (c) rats to hydrazobenzene but was split to aniline only in c-rats. Progoitrin was split with and without the influence of the microflora, but the splitting was more complete in rats with intact gastrointestinal flora.
R
R
Macholz
M
M
Kujawa
J
J
Schulze
H J
HJ
Lewerenz
W
W
Schnaak
D000818:Animals; D001391:Azo Compounds / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D004064:Digestive System / Q000382:microbiology*; D005856:Germ-Free Life; D005961:Glucosinolates / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013865:Thioglycosides / Q000378:metabolism*
D001391:Azo Compounds; D005961:Glucosinolates; D013865:Thioglycosides; C009048:progoitrin; D001556:Hexachlorocyclohexane; C009850:azobenzene