Studies on uricosuric diuretics. I. Syntheses and activities of xanthonyloxyacetic acids and dihydrofuroxanthone-2-carboxylic acids.
A series of substituted xanthonyloxyacetic acids (5 and 6), 1,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-b]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd,. Shizuoka, Japan.
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D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014528:Uricosuric Agents / Q000138:chemical synthesis*; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology
D004232:Diuretics; D005663:Furans; D014528:Uricosuric Agents; D014966:Xanthenes