[Effect of pyromecaine on ionic currents in electrically excitable membranes].
The effects of the local anesthetic pyromecaine on the action potential parameters of the guinea-pig heart ventricular cardiomyocytes as well as on Na and K ionic currents of the neurons in the rat spinal ganglions have been studied. Pyromecaine was shown to reduce preferentially the first derivative of the ascending phase of cardiomyocyte action potential suggesting the blocking action of the anesthetic on the fast sodium inward current. The experiments on the isolated neurons in the rat spinal ganglions have shown that interaction of pyromecaine with inactivated Na+ channels makes a considerable contribution to the blocking effect of anesthesia.
Nazarov
E I
EI
Prianishnikova
N T
NT
Pavlova
L I
LI
Vongaĭ
V G
VG
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D005727:Ganglia, Spinal / Q000187:drug effects*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats
D000779:Anesthetics, Local; D007473:Ion Channels; D011759:Pyrrolidines; C000661:bumecain
Vliianie piromekaina na ionnye toki élektrovozbudimykh membran.