Identification and antigenicity of the major envelope glycoprotein of lymphadenopathy-associated virus.
The major envelope glycoprotein of the causative agent of Acquired Immune Deficiency Syndrome (AIDS) lymphadenopathy-associated virus (LAV) has been identified and characterized. The glycoprotein has an apparent molecular weight of 110,000-120,000 under denaturing conditions in polyacrylamide gel electrophoresis. Upon deglycosylation by a specific endoglycosydase, its size is reduced to 80,000. Cellular precursors of this glycoprotein have been detected with apparent molecular weight of 150,000 and 135,000. Nearly all AIDS and pre-AIDS patients have detectable antibodies against this viral glycoprotein.
Montagnier
L
L
Clavel
F
F
Krust
B
B
Chamaret
S
S
Rey
F
F
Barré-Sinoussi
F
F
Chermann
J C
JC
D002250:Carbon Radioisotopes; D002460:Cell Line; D002478:Cells, Cultured; D003545:Cysteine / Q000378:metabolism; D017977:Deltaretrovirus / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000032:analysis*; D005944:Glucosamine / Q000378:metabolism; D006801:Humans; D037102:Lectins; D008970:Molecular Weight; D013462:Sulfur Radioisotopes; D013601:T-Lymphocytes; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology
D002250:Carbon Radioisotopes; D000939:Epitopes; D037102:Lectins; D013462:Sulfur Radioisotopes; D014759:Viral Envelope Proteins; D003545:Cysteine; D005944:Glucosamine