Does nifedipine reveal a functional abnormality of arteriolar smooth muscle cell in essential hypertension--the effect of altering sodium balance.
Nifedipine, given to both normotensive and hypertensive subjects, caused a greater fall in blood pressure the higher the initial blood pressure. Increasing salt intake enhanced the acute blood-pressure-lowering effect of nifedipine in both normotensive and hypertensive subjects. In hypertensive subjects on longer-term treatment with nifedipine tablets, the addition of bendrofluazide caused no further significant fall in blood pressure. These findings provide circumstantial evidence that there may be a link between sodium intake, sodium balance, and inhibitor of sodium transport, and a functional abnormality of the smooth muscle cell to calcium-entry antagonists.
G A
GA
MacGregor
N D
ND
Markandu
S J
SJ
Smith
G A
GA
Sagnella
D001160:Arterioles / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D004232:Diuretics; D012964:Sodium; D009543:Nifedipine; D002118:Calcium