[Change in levels of specific terminal sugar residues of glycoproteins in sera of patients with complication of diabetes and liver injury].
The concentrations of specific terminal sugar residues of glycoproteins were determined in sera of patients with diabetes, liver injury or complication of both diseases. A significant increase in serum galactose (Gal) concentration was found in all patients. Serum N-acetylneuraminic acid-galactose (NANA-Gal) concentration was significantly decreased in patients with complication of diabetes and liver injury, whereas a high concentration of serum N-acetylneuraminic acid (NANA) was observed only in diabetic patients. Thus the determination of serum Gal and NANA-Gal should be added to one of clinical tests to provide new information on the pathological conditions of diabetes and liver injury.
Department of Biochemistry, School of Hygiene, Fujita Health University, Toyoake.
K
K
Nishida
Y
Y
Nagamura
N
N
Ogitsu
I
I
Ishiguro
M
M
Ito
D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D005693:Galactosemias / Q000097:blood*; D006023:Glycoproteins; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D012794:Sialic Acids / Q000097:blood*
D006023:Glycoproteins; D012794:Sialic Acids