Narcotic withdrawal syndrome in young adults after the therapeutic use of opiates.
Five young adults with malignant neoplasms developed symptoms of narcotic withdrawal six to 48 hours after the abrupt discontinuation of narcotic therapy that had been administered for six to 21 days. The symptoms, which included agitation, irritability, muscular jerks, abdominal pain, diarrhea, burning sensations, "gooseflesh," and itching, rapidly resolved when narcotic therapy was reinstituted. Four patients were then successfully weaned from opiates without recurrence of their withdrawal symptoms; the fifth patient continues to receive methadone hydrochloride treatment for continuing pain.
A W
AW
Miser
K J
KJ
Chayt
J T
JT
Sandlund
P S
PS
Cohen
J A
JA
Dothage
J S
JS
Miser
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy; D002051:Burkitt Lymphoma / Q000188:drug therapy; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000009:adverse effects*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D012516:Osteosarcoma / Q000188:drug therapy; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy; D010502:Perineum; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D009020:Morphine; D004091:Hydromorphone