[Reduction of postoperative edema following isolated hyperthermic perfusion of the extremities with prophylactic administration of aprotinin. Preliminary results].
Experience from more than 380 operations resulted in the standardisation of isolated hyperthermic perfusion with cytostatic drugs for the treatment of malignancies of the extremities. A side-effect of this procedure is postoperative oedema in varying degrees of severity. The influence of prophylactic intraoperative administration of aprotinin (Trasylol) was investigated under experimental and clinical conditions. In these preliminary studies aprotinin distinctly reduced maximum extent and duration of the postoperative oedema. An investigation concerning interaction of aprotinin with the cytotoxic activity of the drugs used in perfusion showed only minor inhibition which does not limit clinical usefulness.
Walther
H
H
Aigner
K R
KR
Link
K H
KH
Helling
H J
HJ
Schwemmle
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use*; D004285:Dogs; D004347:Drug Interactions; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D008545:Melanoma / Q000188:drug therapy; D010477:Perfusion; D011183:Postoperative Complications; D013997:Time Factors
D000970:Antineoplastic Agents; D007611:Aprotinin
Reduktion des postoperativen Odems nach der isolierten hyperthermen Extremitätenperfusion durch prophylaktische Anwendung von Aprotinin. (Vorläufige Ergebnisse).