Characterization of murine hepatoma BW7756. III. Hematological profile of a tumor-associated anemia.
A severe anemia develops in recipient C57L/J mice after syngeneic transplantation of the BW7756 murine hepatoma. The tumor undergoes an exponential growth spurt in the 14-21 days post-implantation, accompanied by a parallel increase in serum alpha-fetoprotein levels and a significant decrease of hemoglobin concentration and hematocrit extending to the 28th day. Concomitant with the decreased hematocrit, the blood volume displayed a 10% increase. The blood cell population was generally one of reticulocytosis and leukocytosis. Mild icteric plasma was observed and both "cold" and "warm" antibodies were detected in the sera of tumor-bearing mice. An elevation of IgM was observed by day 7, followed by a depletion of IgG1 and IgG2 throughout the tumor growth period. When RBCs of tumor-bearing mice were compared to those of normal mice, the same degree of osmotic fragility was found. However, the lifespan of the transfused RBC was shorter in tumor-bearing mice than in normal mice (half-life: 2 days vs. 4 days). The data suggest a type of auto-immune hemolytic anemia which is analogous to various hematopoietic disturbances described for murine hosts bearing solid tumors distal to hematopoietic sites.
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Mizejewski
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Chao
D000743:Anemia, Hemolytic / Q000097:blood / Q000209:etiology*; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001772:Blood Cell Count; D001803:Blood Transfusion; D001810:Blood Volume; D004905:Erythrocyte Aging; D017707:Erythrocyte Transfusion; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007964:Leukocytosis / Q000209:etiology; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D051379:Mice; D009996:Osmotic Fragility; D012156:Reticulocytes; D013194:Staining and Labeling
D001323:Autoantibodies; D006454:Hemoglobins; D007074:Immunoglobulin G; D007075:Immunoglobulin M