The clinical role of OKT3.
The murine monoclonal anti-T-cell antibody, OKT3, has been used during the past 9 years in various clinical transplantation studies. Its use in clinical organ transplantation has advanced the science of MoAb use in humans and has provided a vast amount of evidence substantiating the importance of MoAbs in clinical medicine. Undoubtedly OKT3 has proven to be the most effective and specific immunosuppressive drug widely available for use in organ transplantation.
Division of Nephrology, Oregon Health Sciences University, Portland.
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D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000032:analysis / Q000276:immunology* / Q000627:therapeutic use; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D006084:Graft Rejection / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte