Mammary carcinoma with argyrophilic cells: an immunohistochemical and ultrastructural study.
The immunohistochemical and ultrastructural findings of 7 primary argyrophilic tumors of the breast are described. Five cases were selected because of a growth pattern reminiscent of a "carcinoid" tumor and 2 were obtained from 70 consecutive common carcinomas. All patients were females (mean age 68.8) and none had clinical evidence of hormonal secretion. On ultrastructural examination dense-core granules were seen in addition to findings more suggestive of a common carcinoma. Immunoperoxidase stainings for ACTH, calcitonin etc. were negative in all tumors. The authors believe that organoid growth pattern, argyrophilia and dense-core neurosecretory-like granules are not sufficient elements to demonstrate the endocrine nature of a breast neoplasm.
Santini
D
D
Bazzocchi
F
F
Pileri
S
S
Govoni
E
E
Taffurelli
M
M
Grassigli
A
A
Marrano
D
D
Martinelli
G
G
D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006728:Hormones / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D008875:Middle Aged; D012834:Silver; D013194:Staining and Labeling
D006728:Hormones; D012834:Silver