The effects of interferon on murine erythropoiesis.
The effects of interferon (IF) on erythropoietin (Ep) action and production were studied in mice. In comparison to control animals, Ep action in exhypoxic, polycythemic mice was significantly decreased (p less than 0.05) following two low dose injections of IF (2.9-3.5 X 10(4) units). In addition, renal Ep production in normal intact mice was also significantly decreased (p less than 0.01) following a single injection of IF (5.4-6.3 X 10(4) units) and hypoxic exposure.
Huie
M L
ML
Gordon
A S
AS
Mirand
E A
EA
Leong
S
S
Preti
R A
RA
Naughton
B A
BA
D000818:Animals; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000096:biosynthesis; D000860:Hypoxia / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D051379:Mice
D004921:Erythropoietin; D007372:Interferons