[Experimental study of preventing emphysema with elastase inhibiting agents].
We have observed the influence of Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum on the elastase activity and the protective effects of the two medicines on the elastic fibers. The results showed that Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum can inhibit the activity of porcine pancreatic elastase and human sputum elastase. These two drugs can protect arterial and pulmonary elastic fibers from the destruction of elastase. Since these traditional Chinese herbs have little toxic effect and no antigenic character, they can be used in the preventing emphysema. The study suggest that it is useful Radix Salviae Miltiorrhizae and Ligustrazini Hydrochloridum are as favourable elastase inhibiting agents, which may be used in the prevention of emphysema extensively.
Division of Pulmonary Diseases, First Affiliated Hospital of Harbin Medical University, Harbin.
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D000818:Animals; D001011:Aorta / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004547:Elastic Tissue / Q000187:drug effects; D004646:Emphysema / Q000517:prevention & control*; D006801:Humans; D008168:Lung / Q000187:drug effects; D008173:Lung Diseases, Obstructive / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010618:Phenanthrolines / Q000494:pharmacology*; D010936:Plant Extracts; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D027561:Salvia miltiorrhiza
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; D011719:Pyrazines; C028972:dan-shen root extract; D010196:Pancreatic Elastase; C017953:tetramethylpyrazine