[Lymphocyte function in patients with anti-D(Rh0) antibodies].
The behaviour of humoral and cellular immunity as well as that of cells bearing Fc receptors was investigated in persons with anti-D antibodies. Peripheral lymphocytes could be identified in 6 of 26 examined test persons particularly sensitized against the stroma of Rh-positive erythrocytes. There was no relation to the anti-D titre. The parameters of humoral immunity showed no correlation to the anti-D titre. In 37 per cent of the persons with anti-D antibodies, which were produced "naturally" or artificially, an increased content of IgE could be proved in the serum. In each case, anti-D formation apparently leads to an increase of cells bearing Fc receptors, which can be recognized by the increased number of EA rosettes. A relation to the anti-D titre did not exist. None of the immunological test methods used is suitable for predicting the success of an artificial immunization for the purpose of gaining high titre anti-D antibodies.
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Uhlig
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Göring
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Schwalm
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D001788:Blood Grouping and Crossmatching; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D011961:Receptors, Fc / Q000276:immunology; D012203:Rh Isoimmunization / Q000276:immunology*; D012397:Rosette Formation
D000888:Antibodies, Anti-Idiotypic; D007072:Immunoglobulin D; D011961:Receptors, Fc
Untersuchungen über die Lymphozytenfunktion bei Personen mit Anti-D(Rh0)-Antikörpern.