Antibacterial activities of antineoplastic agents.
Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Only 5-fluorouracil, mitomycin, and etoposide demonstrated inhibitory effects at achievable plasma concentrations, while the remaining drugs lacked appreciable antibacterial activities.
C A
CA
Bodet
J H
JH
Jorgensen
D J
DJ
Drutz
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001761:Bleomycin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005047:Etoposide / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology
D000970:Antineoplastic Agents; D008937:Mitomycins; D001761:Bleomycin; D016685:Mitomycin; D005047:Etoposide; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate