[Role of the kallikrein-kinin system and prostaglandins in the action of dopamine on blood flow and sodium transport in the rat kidney].
In anesthetized rats, dopamine (1 mg/kg) increased the blood flow in adrenal and external medullary layers of kidneys with accompanying obvious sodium-uretic response due to inhibition of sodium reabsorption, PO2 not changing, at that. Haloperidol (1 mg/kg) prevented the hemodynamic shift and its depressing effect on the sodium transport in the kidney channels. The inhibiting agent for kallikrein-kinin system contrical and inhibiting agent for prostaglandin synthetase indomethacin did not alter the kidney response to the neurotransmitter under study. The intrarenal hemodynamic shift and inhibition of sodium transport induced with dopamine seem to be due to stimulation of renal postsynaptic dopamine receptors and unrelated to activation of the renal kallikrein-kinin system or augmentation of prostaglandins synthesis.
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Kuz'min
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Kriukova
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000502:physiology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007705:Kinins / Q000502:physiology*; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000378:metabolism*
D007705:Kinins; D011453:Prostaglandins; D007611:Aprotinin; D012964:Sodium; D007610:Kallikreins; D006220:Haloperidol; D004298:Dopamine; D007213:Indomethacin
Rol' kallikrein-kininovoĭ sistemy i prostaglandinov v deĭstvie dofamina na krovotok i transport natriia v pochke krysy.