Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve.
The peptide, substance P (SP), is suspected of being a mediator of nociception. Immunoreactive SP is conspicuously present in areas of the mammalian central nervous system which receive nociceptive input. We have observed that compression of the trigeminal nerve by an intradural tumour deposit results in the ipsilateral depletion of SP immunoreactivity in human spinal trigeminal nucleus. These results expand previous experimental animal studies which associate this peptide with a subpopulation of primary sensory neurones and, in addition, demonstrate a correlation between the levels of SP immunoreactivity and premortem clinical sensory alterations.
E P
EP
Pioro
J T
JT
Hughes
A C
AC
Cuello
D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000556:secondary; D004388:Dura Mater; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000556:secondary; D009408:Nerve Compression Syndromes / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D010190:Pancreatic Neoplasms; D013373:Substance P / Q000276:immunology*; D014276:Trigeminal Nerve; D014279:Trigeminal Nucleus, Spinal / Q000276:immunology*
D013373:Substance P