[New methods in the radiotherapy of bronchial carcinoma. Endobronchial small-field irradiation using the iridium-129 high-dose afterloading technic in combination with the neodymium-YAG laser].
106 patients with inoperable malignant tumours constricting the central bronchial tree underwent endobronchial small-field radiotherapy with iridium-192 at high dose between June 1983 and September 1985. Treatment was performed using the computer-guided after-loading technique and a flexible bronchoscope under local anaesthesia. In complete occlusion of a bronchus by the tumour, a neodymium YAG-laser was applied (57 patients) to allow insertion of the after-loading probe. Endoscopy showed tumour regression in 75% of the patients, accompanied by clinical improvement. Pulmonary function tests, arterial blood gas analyses and pulmonary perfusion scans yielded a highly significant improvement of data after treatment. The procedure also proved effective upon exhaustion of external radiation. Apart from its positive palliation, endobronchial small-field radiotherapy using high doses of iridium-192 also has a curative effect, thus opening up a new approach to the therapy of advanced bronchial carcinoma.
H N
HN
Macha
J
J
Mai
M
M
Stadler
K
K
Koch
R
R
Loddenkemper
D
D
Krumhaar
W
W
Schumacher
D000368:Aged; D001918:Brachytherapy / Q000379:methods; D001982:Bronchial Diseases / Q000209:etiology / Q000601:surgery*; D001999:Bronchoscopy; D002283:Carcinoma, Bronchogenic / Q000150:complications / Q000532:radiotherapy*; D003251:Constriction, Pathologic / Q000601:surgery; D005260:Female; D006801:Humans; D007495:Iridium / Q000627:therapeutic use*; D053685:Laser Therapy; D008175:Lung Neoplasms / Q000150:complications / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009354:Neodymium; D010166:Palliative Care; D011868:Radioisotopes / Q000627:therapeutic use*
D011868:Radioisotopes; D009354:Neodymium; D007495:Iridium
Neue Wege der Strahlentherapie des Bronchialkarzinoms. Die endobronchiale Kleinraumbestrahlung mit der Iridium-192-High-dose-After-loading-Technik in Kombination mit dem Neodym-YAG-Laser.