Comparison of the effects of substance P and substance K on blood pressure, salivation and urinary bladder motility in urethane-anaesthetized rats.
The effects of substance P and substance K on blood pressure, salivation and urinary bladder motility were investigated in urethane-anaesthetized rats. On intravenous administration, both peptides produced dose-related reductions in blood pressure, substance P being 25-30 times more potent than substance K. Substance P induced a dose-dependent increase of salivation, while substance K was half as active and induced only 40% of the maximum effect of substance P. The two tachykinins induced contractions of the urinary bladder, substance K being about twice as effective as substance P. Substance K was more effective than substance P in activating micturition. These findings provide further evidence that multiple receptor types are involved in mediating the effects of tachykinins in peripheral organs.
C A
CA
Maggi
S
S
Giuliani
P
P
Santicioli
D
D
Regoli
A
A
Meli
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D015288:Neurokinin A; D051381:Rats; D011919:Rats, Inbred Strains; D012472:Salivation / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D014520:Urethane / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects*
D009419:Nerve Tissue Proteins; D013373:Substance P; D014520:Urethane; D015288:Neurokinin A