Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats.
The regional distribution of substance P (SP) and substance K (SK) in the central nervous system and peripheral tissues of rats was studied. High levels of SK-like immunoreactivity (SK-LI) and of SP-like immunoreactivity (SP-LI) were found in the substantia nigra, nucleus tractus solitarius and nucleus habenula. Neonatal treatment of rats with capsaicin caused a significant decrease in the SK-LI content in the submaxillary gland, but capsaicin had no effect on SK-LI content in any area of the brain. These observations suggest that SK in the brain and peripheral tissues may have significant physiological roles.
Takano
Y
Y
Nagashima
A
A
Masui
H
H
Kuromizu
K
K
Kamiya
H O
HO
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002490:Central Nervous System / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007082:Ileum / Q000032:analysis; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D015288:Neurokinin A; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D014649:Vas Deferens / Q000032:analysis
D009419:Nerve Tissue Proteins; D013373:Substance P; D015288:Neurokinin A; D002211:Capsaicin