Percutaneous treatment with a mucopolysaccharide polysulphate of experimentally induced subcutaneous haematomas in man.
In a double blind trial on ten healthy volunteers, the efficacy of a topically applied mucopolysaccharide polysulphate in the treatment of subcutaneous haematomas was assessed. Standardized haematomas were induced by subcutaneous injection of a mixture of autogenous blood and 125I-fibrinogen. The absorption of the haematoma, expressed as the removal of the labelled fibrin(ogen), could thus be objectively measured by the decrease in radioactivity. The results show an exponential absorption of these haematomas. The absorption time was reduced to about half compared with placebo, when treated topically with mucopolysaccharide polysulphate. The difference is statistically highly significant and is also considered clinically relevant.
Larsson
B
B
Fianu
S
S
Jonasson
A
A
Forsskåhl
B
B
D000287:Administration, Topical; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005340:Fibrinogen / Q000502:physiology; D006406:Hematoma / Q000188:drug therapy* / Q000503:physiopathology; D006496:Heparinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013997:Time Factors
D006496:Heparinoids; C046596:Hirudoid; D005340:Fibrinogen