Developing rat brain monoamine levels following in utero exposure to a mixture of 2,4-dichlorophenoxyacetic and 2,4,5-trichlorophenoxyacetic acids.
Pregnant rats were gavaged with a 1:1 mixture of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) at 0 (G0), 50 (G 50) and 100 (G 100) mg/kg per day on gestational days 6-15. Treatment significantly (P less than 0.05) delayed ontogeny of dopamine (DA), but not norepinephrine (NE) levels, in the thalamus-hypothalamus on postnatal day 7; in the pons-medulla on days 7,9 and 15; and in the olfactory lobes on day 9. On day 25, serotonin (5-HT) levels were significantly decreased in the pons-medulla of G 100 rats, whereas 5-hydroxyindoleacetic acid (5-HIAA) levels decreased in the thalamus-hypothalamus and pons-medulla of G 50 and G 100 rats.
Mohammad
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St Omer
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D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D009043:Motor Activity; D009638:Norepinephrine / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D001679:Biogenic Amines; D015084:2,4-Dichlorophenoxyacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D004298:Dopamine; D009638:Norepinephrine