Glutamine nutrition in the management of radiation enteritis.
Although glutamine-supplemented diets appear to be beneficial in the model described here, carefully designed clinical trials must be done before such therapy is recommended in patients receiving XRT. Such studies should examine the efficacy of glutamine-enriched parenteral nutrition as well as enteral feedings. They must address the issue of potential stimulation of tumor growth by glutamine supplementation. In addition, the question has been raised as to whether glutamine will result in the tumor being more refractory to radiation therapy.
Souba
W W
WW
Department of Surgery, University of Florida College of Medicine, Gainesville.
Klimberg
V S
VS
Copeland
E M
EM
D000284:Administration, Oral; D000818:Animals; D004751:Enteritis / Q000209:etiology / Q000628:therapy*; D005526:Food, Formulated; D005973:Glutamine / Q000008:administration & dosage* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism / Q000528:radiation effects; D007422:Intestines / Q000382:microbiology; D011379:Prognosis; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D051381:Rats
D005973:Glutamine