Cutaneous phaeohyphomycosis caused by a rare fungal pathogen, Hormonema dematioides: successful treatment with ketoconazole.
Annular, fungating, ulcerated lesions developed on both hands of a 64-year-old immunocompetent man 2 months after he was cut with barbed wire. A dematiaceous mold, Hormonema dematioides, heretofore not definitively associated with human disease, was grown from two separate tissue specimens during a period of 9 days. Histopathologic examination demonstrated rare small, periodic acid-Schiff-positive, hyaline, yeastlike organisms in tissue. Twelve weeks of empiric therapy with ketoconazole, 400 mg/day, was curative.
Department of Dermatology, University of Cincinnati, OH.
B M
BM
Coldiron
E L
EL
Wiley
M G
MG
Rinaldi
D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006229:Hand Dermatoses / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000302:isolation & purification; D010859:Pigmentation Disorders / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology
D007654:Ketoconazole