Serum factors for opsonisation of non-typable Haemophilus influenzae.
Neutrophil chemiluminescence was used to assess the opsonins required for phagocytosis of non-typable Haemophilus influenzae isolated from sputum samples of patients with hypogammaglobulinaemia. Immunoglobulin was the major opsonin, whereas complement was relatively unimportant. Evidence was found for a heat-labile opsonin other than complement that enhanced phagocytosis of these organisms. Tuftsin was shown to aid phagocytosis of H. influenzae without triggering chemiluminesence.
Lever
A M
AM
Gross
J
J
Webster
A D
AD
D000361:Agammaglobulinemia / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D005353:Fibronectins / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000145:classification / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins; D010587:Phagocytosis; D014405:Tuftsin / Q000494:pharmacology; D005719:gamma-Globulins / Q000276:immunology*
D005353:Fibronectins; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D005719:gamma-Globulins; D003165:Complement System Proteins; D014405:Tuftsin