[Importance of immunohistochemistry for neuro-oncology. II. Localization of factor VIII-associated proteins and glial fibrillary acidic protein (GFAP) in angiomatous and sarcomatous tumors].
Immunhistochemical methods utilizing specific antibodies against Factor VIII-related antigen and glial fibrillary acidic protein were employed in studies of 48 intracranial and intraspinal tumors. Factor VIII-related antigen occurred only in endothelial cells of the vascular wall and is therefore not of importance for the differential diagnosis of CNS tumors. Isolated Factor VIII positive cells in the stroma of hemangioblastomas turned out to be mast cells which may also normally contain this substance. The GFAP positive cells in hemangioblastomas are believed to all be of astrocytic lineage. Many of the multinuclear giant cells present in monstrocellular sarcomas contained GFAP but were Factor VIII negative. Genuine fibroxanthoma of the meninges can apparently exist next to pleomorphic xanthoastrocytomas. As demonstrated by one of our cases, the demonstration of GFAP alone can successfully distinguish between them.
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Gottschalk
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H
Martin
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H
Barz
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J
Szymaś
D000912:Antibodies, Neoplasm / Q000032:analysis; D000941:Antigens / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D009423:Nervous System Neoplasms / Q000145:classification / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000473:pathology; D013194:Staining and Labeling; D014841:von Willebrand Factor
D000912:Antibodies, Neoplasm; D000941:Antigens; D005904:Glial Fibrillary Acidic Protein; D014841:von Willebrand Factor; D005169:Factor VIII
Bedeutung der Immunhistochemie für die Neuroonkologie. II. Mittelung: Lokalisation des Faktor VIII-assoziierten Proteins und sauren Gliafaserproteins (GFAP) in angiomatösen und sarkomatösen Tumoren.