Pregnancy following treatment of endodermal sinus tumor of the ovary with combination chemotherapy, including cis-platinum.
A 16-year-old woman with endodermal sinus tumor of the ovary underwent conservative surgical debulking and combination chemotherapy and had a recurrence documented by a rise in alpha-fetoprotein. She had a complete response to a second chemotherapy regimen, including cis-platinum. Subsequently, she became pregnant. The case emphasizes the management of endodermal sinus tumor, including conservative surgery, combination chemotherapy, and monitoring serum alpha-fetoprotein levels. This is the second report of pregnancy following cis-platinum administration.
Curtin
J P
JP
Adcock
L L
LL
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000188:drug therapy* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D010052:Ovariectomy; D011247:Pregnancy; D012306:Risk; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins; D001761:Bleomycin; D003609:Dactinomycin; D014750:Vincristine; D014747:Vinblastine; D003520:Cyclophosphamide; D002945:Cisplatin