Rat anti-glomerular basement membrane antibodies in toxin-induced autoimmunity and in chronic graft-vs.-host reaction share recurrent idiotypes.
Cross-reactive idiotypes (CRId) borne on autoanti-glomerular basement membrane antibodies of Brown-Norway (BN) rats with mercury-induced glomerulonephritis have been described in the preceding study (Guéry, J.-C. et al., Eur. J. Immunol. 1990. 20:93). BN rats treated with sodium aurothiopropanol sulfonate or D-penicillamine, as well as (LEW X BN)F1 hybrids transferred with BN rat spleen cells, developed quite similar autoimmune abnormalities. In the present study, it is shown that immunoglobulins bearing such "public" idiotypes are also produced and deposited in the kidney in these three models. The CRId here described may, therefore, be considered as a marker of sets of recurrently expressed V region genes during the course of these autoimmune disorders. Anti-self class II T cells are present in the three models of toxin-induced autoimmunity and anti-allo class II T cells are responsible for the chronic graft-vs.-host reaction. The same B cell clones are probably triggered during these processes as a consequence of a polyclonal B cell activation mediated by anti-class II T cells.
Unité 28, Institut National de la Santé et de la Recherche Médicale, Hôpital Broussais, Paris, France.
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JC
Guéry
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Tournade
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Pelletier
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E
Druet
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Druet
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D003429:Cross Reactions; D004112:Dimercaprol; D005455:Fluorescent Antibody Technique; D006087:Graft vs Host Reaction; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*; D007797:Laminin / Q000276:immunology; D008627:Mercuric Chloride; D008667:Metalloproteins; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013438:Sulfhydryl Compounds
D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D007797:Laminin; D008667:Metalloproteins; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D008627:Mercuric Chloride; C013394:aurotioprol