Griseofulvin-induced protoporphyria revisited.
In nude mice grieofulvin given by intraperitoneal injections produces a severe porphyric state within 1 week. Compared with peroral administration of griseofulvin to produce experimental porphyria, this model is much more efficient and can be more easily controlled.
Department of Clinical Chemistry, University of Trondheim, University Hospital, Norway.
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Gederaas
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Brekke
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Romslo
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002853:Chromatography, Liquid; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000187:drug effects; D006118:Griseofulvin / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*; D012871:Skin Diseases / Q000139:chemically induced*
D011166:Porphyrins; D011524:Protoporphyrins; D006118:Griseofulvin