Immunogenic potentials of copolymer I in normal human lymphocytes.
Copolymer I (COP I), a nonencephalitogenic polypeptide analogous to myelin basic protein, is currently being tested for possible effectiveness in treating MS. Peripheral blood mononuclear cells from normal human donors respond blastogenically to the L-form of COP I. This response was greater than that obtained with either bovine or guinea pig myelin basic protein (GPMBP), with no specificity for a particular T-cell subset. Analyses of culture supernatants demonstrated the presence of interleukin-2 and gamma interferon. Mononuclear cells from human fetal cord blood also responded blastogenically to COP I, but the magnitude of the response did not differ from that induced by GPMBP.
C F
CF
Brosnan
M
M
Litwak
P A
PA
Neighbour
W D
WD
Lyman
T H
TH
Carter
M B
MB
Bornstein
B R
BR
Bloom
D000818:Animals; D000941:Antigens / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D010455:Peptides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology
D000941:Antigens; D008222:Lymphokines; D004676:Myelin Basic Protein; D010455:Peptides; C021759:(T,G)-A-L