Monoclonal and oligoclonal immunoglobulins localized in human dental periapical lesion.
The gamma-globulin fractions of extracts obtained from 70 periapical lesions were studied by agarose gel electrophoresis and immunofixation. In agarose gel electrophoresis, homogeneous bands in the gamma-globulin region were found in 25 of 70 specimens (36%). Among the 25 specimens showing homogeneous bands, these bands in six specimens were identified as monoclonal or oligoclonal immunoglobulins. Local production of oligoclonal immunoglobulins was suggested since the corresponding homogeneous bands were not detected in the serum of the same patient. These immunoglobulins may be produced as a result of local immunogenic response against infecting bacteria in periapical inflammation.
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Matsumoto
D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000302:isolation & purification; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007120:Immunochemistry; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000302:isolation & purification; D010484:Periapical Granuloma / Q000276:immunology*; D005719:gamma-Globulins / Q000302:isolation & purification
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D005719:gamma-Globulins