Survival of L1210 leukemia cells and normal hematopoietic stem cells following in vivo administration of cyclocytidine.
The survival of L1210 cells following increasing doses of cyclocytidine (cyclo-C) was determined by spleen colony assay. For single dose, cyclo-C was effective reaching a fractional survival of less than 10(-3) at 10 mg/mouse. This is significantly more effective than a similar dose of arabinosyl cytosine (ara-C) given by rapid infusion. The time-survival curve demonstrated extended cytotoxicity following a single 10 mg/mouse dose of cyclo-C as expected for a long-acting agent. When a 24-hour infusion was examined, however, ara-C was more effective than cyclo-C by a factor of about 10. The clinical implication of this is discussed.
Valeriote
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Muntz
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Vietti
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TJ
D003504:Ancitabine / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003114:Colony-Forming Units Assay; D003561:Cytarabine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007939:Leukemia L1210 / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013997:Time Factors
D003561:Cytarabine; D003504:Ancitabine