Mutagenic activity of radiosensitizers.
Seven radiosensitizers, six derivatives of nitroimidazole (coded P1 to P5 and one imidazole derivative--P6 were investigated for mutagenicity using 3 short-term tests: Ames test, prophage lambda induction and tryptophan reversion test. Out of seven investigated compounds five were not mutagenic. Only P1 derivative induces base pair substitutions. Another derivative of nitroimidazole: metronidazole induces base pair substitution and frameshift mutations. Its positive response in the prophage lambda induction test suggests that metronidazole provokes also epigenetic changes.
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Grzybowska
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Kalinowska
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Szala
D000818:Animals; D010582:Bacteriophage lambda / Q000254:growth & development; D001483:Base Sequence / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008862:Microsomes, Liver; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D009593:Nitroimidazoles / Q000494:pharmacology*; D011815:R Factors / Q000187:drug effects; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D014775:Virus Activation / Q000187:drug effects
D009153:Mutagens; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole