Candida-induced histamine release from basophils: relationship to house dust- and anti-IgE-induced secretion.
Candida albicans-induced histamine release from basophils was studied in 54 patients with bronchial asthma in comparison with the release caused by house dust and anti-IgE. The release of histamine induced by C. albicans and that induced by house dust were closely related to the serum levels of specific IgE antibodies as expressed by RAST scores. A correlation of C. albicans-induced histamine release with the release caused by anti-IgE was not generally observed. On the other hand, a close correlation was found between house dust- and anti-IgE-induced histamine release. It was suggested from these results that the differences between C. albicans- and house dust-induced histamine release might be due to the different antigenicity of the two allergens.
Tanizaki
Y
Y
Komagoe
H
H
Sudo
M
M
Morinaga
H
H
Kitani
H
H
Nakagawa
S
S
Matsuoka
T
T
Tada
S
S
Takahashi
K
K
Kimura
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D001491:Basophils / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D004391:Dust; D005260:Female; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic; D000946:Antigens, Fungal; D004391:Dust; D007073:Immunoglobulin E