Naturally occurring anti-native DNA antibodies in SLE binding Z-DNA.
A high degree of specificity of circulating anti-DNA antibody for double stranded DNA in the sera of SLE patients was found, as compared to single stranded polymer. The antibody recognized brominated DNA, a polymer that appears to attain Z-conformation as indicated on the basis of UV absorption characteristics. The existence in native DNA of regions undergoing B----Z transition has been detected.
Department of Biochemistry, Faculty of Medicine, Aligarh Muslim University.
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Sehgal
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Ali
D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D004247:DNA / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D009690:Nucleic Acid Conformation
D001323:Autoantibodies; D004247:DNA