[Several copies of angiogenin gene are present in the mammalian genome].
Human cDNAs coding for angiogenin were isolated from Li7 hepatoma. Analysis of the nucleotide sequences of isolated cDNA clones and its comparison with recently published sequences of cDNA and human angiogenin gene permitted to suggest that an intron is present in the 5' region of the gene, dividing the coding and 5' untranslating regions. The size of the intron exceeds 1700 b.p. Up to now it has been known that the angiogenin gene is a single copy gene. However our results of blot-hybridization with genomic DNA of some mammals showed that there are 2-3 copies of the gene in their genomes. According to our results the angiogenin gene is conserved in mammalian genomes.
N S
NS
Neznanov
I V
IV
Makarova
I A
IA
Kramerova
K A
KA
Bendukidze
V M
VM
Bozhkov
K G
KG
Gazarian
D043925:Angiogenesis Inducing Agents / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005091:Exons; D015894:Genome, Human; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D011506:Proteins / Q000235:genetics*; D012259:Ribonuclease, Pancreatic; D012689:Sequence Homology, Nucleic Acid
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances; D011506:Proteins; D004247:DNA; C046366:angiogenin; D012259:Ribonuclease, Pancreatic
Gen angiogenina predstavlen neskol'kimi kopiiami v genomakh mlekopitaiushchikh.