[Differential pulse voltammetry: focus on the measurement of 5-hydroxyindole compounds and uric acid in the brain].
The electrochemical signal obtained at the +300 mV potential (peak 3) in rats implanted for more than one week could be dependent upon extracellular fraction of 5-hydroxyindolacetic acid (5-HIAA) since a single injection of Pargyline is sufficient to suppress it in caudate and raphe dorsalis nuclei. In contrast, in rats implanted for less than one week, this signal could be dependent upon extracellular fractions of 5-HIAA and uric acid since consecutive injections of Pargyline and Allopurinol are necessary to suppress it.
R
R
Cespuglio
A
A
Gharib
N
N
Sarda
N
N
Chastrette
H
H
Faradji
B
B
Delobel
D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004567:Electrodes, Implanted; D005110:Extracellular Space; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D010084:Oxidation-Reduction; D011199:Potentiometry / Q000379:methods; D051381:Rats; D013997:Time Factors; D014527:Uric Acid / Q000032:analysis*
D014527:Uric Acid; D006897:Hydroxyindoleacetic Acid
Voltamétrie impulsionnelle différentielle: mise au point concernant la mesure des composés 5-hydroxyindols et de l'acide urique au niveau du cerveau.