Lymphadenopathy due to fatal histiocytic proliferative disorder containing Michaelis-Gutmann bodies.
A 59-year-old white man had generalized lymphadenopathy, fever, weight loss, and hypercalcemia. Histologic examination of seven lymph nodes from three different anatomic sites revealed a diffuse histiocytic infiltrate containing numerous typical Michaelis-Gutmann (MG) bodies. Histochemical and immunohistochemical results confirmed the histiocytic nature of the predominant cell within the infiltrate. Approximately equal numbers of residual normal B-cells, T-helper, and T-suppressor cells were present. Electron microscopy revealed extracellular and intracellular MG bodies, many of which were membrane-bound. Special stains, electron microscopy, and lymph node culture did not demonstrate microorganisms. The histologic features of the infiltrate were those of malacoplakia. However, the disease behaved like a lymphoma, with the occurrence of lymphadenopathy and a fatal outcome.
P A
PA
Dervan
M
M
Teeling
J
J
Dempsey
I M
IM
Drury
E
E
O'Malley
D
D
O'Connell
D001402:B-Lymphocytes / Q000473:pathology; D003937:Diagnosis, Differential; D005629:Frozen Sections; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000097:blood / Q000150:complications / Q000209:etiology / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology; D008287:Malacoplakia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology