Axonal transport of substance P-like immunoreactivity in regenerating rat sciatic nerve.
Anterograde axonal transport of substance P-like immunoreactivity (SPLI) decreases after injury (crush or resection) to rat sciatic nerve. If the axons regenerate a partial recovery of transport occurs. If regeneration is impeded the decrease in transport is more severe and prolonged. No changes in the proportion of mobile SPLI (31%) or transport velocity (10.0 mm/h) occur. The decrease in SPLI transport largely accounts for the decline in SPLI content which occurs in nerve following injury and probably reflects decreased cell body synthesis.
M A
MA
Bisby
P
P
Keen
D000818:Animals; D001370:Axonal Transport; D004525:Efferent Pathways / Q000502:physiology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D012584:Sciatic Nerve / Q000502:physiology*; D013373:Substance P / Q000378:metabolism*
D013373:Substance P