Sertoli-Leydig cell tumor of the ovary with alpha-fetoprotein production.
A case of poorly differentiated Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein (AFP) levels occurred in a 17-year-old girl. No germ cell component and no heterologous elements were identified, but a retiform pattern was present. Immunohistochemical studies demonstrated immunoreactivity for AFP and testosterone in Leydig's cells only. Secretion of AFP by Sertoli-Leydig cell tumors has rarely been mentioned previously, and its mechanism is difficult to explain. Non-germ cell tumors must be considered in the differential diagnosis of ovarian tumors with elevated serum AFP levels.
Tetu
B
B
Ordóñez
N G
NG
Silva
E G
EG
D000293:Adolescent; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007984:Leydig Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D012707:Sertoli Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins