Free estrogens and progestogens in benign prostatic hypertrophy.
Studies on the presence of free estrogens and progestogens in human prostates clearly differentiate the benign hypertrophied prostates from normals. Both contained 17 alpha-hydroxypregnenolone 5 beta-pregnane-3, 20-dione, 5 alpha-pregnane-3, 20-dione and 16 alpha-hydroxyestrone. However, presence of 11 alpha-hydroxyprogesterone 20 beta-hydroxypregnenolone, pregnenolone, 17 alpha-hydroxyprogesterone, as well as estrone and estriol exclusively in BPH samples pointed to their possible involvement in the development of benign prostatic hypertrophy.
J P
JP
Narayan
S P
SP
Srivastava
J N
JN
Singh
D000368:Aged; D002855:Chromatography, Thin Layer; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011372:Progestins / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*
D004967:Estrogens; D011372:Progestins