[Prevalence, therapeutic modification and prognostic significance of ventricular arrhythmias in the mitral valve prolapse syndrome].
82 patients clinically and echocardiographically identified as having mitral valve prolapse were examined with regard to the incidence of ventricular arrhythmias and their therapeutic and prognostic implications. 73 patients (89%) had ventricular extrasystoles in the 24 hour ambulatory ECG, 33 (40%) of them with an average of more than 30/h. Severe forms like multiform or paired ventricular extrasystoles and nonsustained ventricular tachycardias have been registered in 28 (34%), 26 (32%) and 9 patients (11%) respectively. There is a correlation between the incidence of the arrhythmias and time of registration which corresponds to a natural logarithm. A prolongation of the time of registration to more than 24 hours therefore implies no essential benefit. The incidence and the number of ventricular arrhythmias demonstrated a significant decrease during sleep. The incidence of ventricular pairs and/or ventricular tachycardias was 13% during the night (0-6 h) in comparison with at least 22% during the three daytime periods (6-12 h, 12-18 h and 18-24 h). There was no correlation between the incidence or severity of ventricular arrhythmias and the patients' ages of left ventricular performance.(ABSTRACT TRUNCATED AT 250 WORDS)
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D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology*; D001262:Atenolol / Q000627:therapeutic use; D005117:Cardiac Complexes, Premature / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000209:etiology; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000150:complications* / Q000188:drug therapy; D011379:Prognosis; D013610:Tachycardia / Q000209:etiology
D001262:Atenolol
Prävalenz, therapeutische Beeinflussung und prognostische Bedeutung ventrikulärer Arrhythmien beim Mitralklappenprolapssyndrom.