Open lung biopsy in immunocompromised patients.
From January 1978 through December 1980, ninety-five immunocompromised patients underwent diagnostic open lung biopsy (OLB) at the Mayo Clinic, Rochester, Minn. A specific causative diagnosis was made in 77 patients (81%); 12 patients (13%) had more than one specific causative diagnosis. Of the 77 patients with a specific causative diagnosis, 52 patients (68%) had infections, 19 patients (24%) had malignant pulmonary disease, 12 patients (15%) had cytotoxic lung disease, ten patients (13%) had interstitial fibrosis (not related to cytotoxins), and one patient (1%) had vasculitis. In 36 (47%) of the 77 patients with a specific causative diagnosis, the diagnosis was made, by frozen sections or stains, within three hours of OLB. In 35 additional patients (45%), the diagnosis was established within 24 hours. Twelve patients (13%) had minor complications of OLB; no deaths were attributed to the OLB procedure.
Cockerill
F R
FR
Wilson
W R
WR
Carpenter
H A
HA
Smith
T F
TF
Rosenow
E C
EC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001706:Biopsy / Q000379:methods; D001999:Bronchoscopy; D002648:Child; D005260:Female; D005629:Frozen Sections; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D007108:Immune Tolerance; D007674:Kidney Diseases / Q000150:complications; D008171:Lung Diseases / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D011183:Postoperative Complications / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000150:complications; D012141:Respiratory Tract Infections / Q000150:complications / Q000382:microbiology; D012189:Retrospective Studies; D013194:Staining and Labeling; D014652:Vascular Diseases / Q000150:complications
D000970:Antineoplastic Agents