Blastogenesis-suppressing serum factors, decreased immunoglobulin A, and increased beta 1-globulins in Airedale Terriers with diskospondylitis.
In Airedale Terriers with diskospondylitis, immunologic tests revealed heat-stable blastogenesis-suppressing serum factors affecting primarily the effector (phytohemagglutinin-sensitive) lymphocytes; decreased serum concentrations of immunoglobulin A; and increased serum concentrations of undetermined beta 1-globulins. Data indicated that the dogs had decreased immunoglobulin A production and were immunosuppressed, which probably contributed to penetration of bacteria into the body and subsequent spreading to the disks. Eosinophilia and basophilia were also detected, which indicated a potential for a type-I hypersensitivity reaction that may have ameliorated the inflammatory reaction.
Barta
O
O
Turnwald
G H
GH
Shaffer
L M
LM
Pourciau
S S
SS
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000662:veterinary*; D001609:Beta-Globulins / Q000378:metabolism*; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D005260:Female; D007070:Immunoglobulin A / Q000378:metabolism*; D007376:Interleukin-2 / Q000032:analysis; D007403:Intervertebral Disc; D007958:Leukocyte Count / Q000662:veterinary; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D013166:Spondylitis / Q000276:immunology / Q000662:veterinary*
D001609:Beta-Globulins; D007070:Immunoglobulin A; D007376:Interleukin-2; D008222:Lymphokines; C027779:blastogenic factor