Anti-platelet action of an anti-allergic agent, N-(3',4'-dimethoxycinnamoyl)anthranilic acid (tranilast).
The effects of N-(3',4'-dimethoxycinnamoyl)anthranilic acid (Tranilast), a blocker for histamine release from mast cells, on rabbit blood platelet functions were investigated. Tranilast inhibited dose dependently both the release of a lysozomal enzyme, beta-N-acetylglucosaminidase, and aggregation of washed rabbit platelets stimulated by thrombin and collagen. The IC50 was suspected to be 164 +/- 50 microM. The data suggest that Tranilast may be used as an anti-platelet agent in addition to an anti-allergic one.
Iwasa
Y
Y
Iwasa
T
T
Matsui
K
K
Yoshimura
T
T
Tanaka
N
N
Miyazaki
K
K
D000118:Acetylglucosaminidase / Q000097:blood; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D062367:ortho-Aminobenzoates; D000118:Acetylglucosaminidase; C012293:tranilast