Immunomodulation by some oligopeptides.
The influence of bradykinin, some of its analogues, substance P and different partial sequences on lymphoid cells was studied under in vitro conditions. The oligopeptides bradykinin and substance P were found to be able to induce the secretion of charge-changing and chemokinetic lymphokines in very low concentrations. In each case, bell-shaped dose-response curves were registered in a concentration range from 10(-12) to 10(-6) M. An analysis of the lymphokine patterns suggests that T cells are the producer cells of charge-changing lymphokines. Comparing the structure-activity relationships of the peptides, the amino acid sequence Arg-Pro at the N-terminal region of bradykinin and substance P or Pro-Arg at the C-terminal part of tuftsin and rigin appear to be responsible for the lymphokine secretion.
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Paegelow
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Werner
D000276:Adjuvants, Immunologic; D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004586:Electrophoresis / Q000379:methods; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D008222:Lymphokines; D009842:Oligopeptides; D003208:Concanavalin A; D013373:Substance P; D001920:Bradykinin