Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera.
Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.
P W
PW
Bland
L G
LG
Warren
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology*; D007700:Kinetics; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera