[Comparative study of the behavior of particulate emissions from diesel and gasoline engines in animal lungs: elimination rate and induction of benzo(a)pyrene hydroxylase and ethoxycoumarin de-ethylase].
The emitted particulates of five diesel-engined and two gasoline-engined passenger cars were investigated for the elimination rate from hamster lungs after intratracheal instillation. In addition extracts of these particulates were studied for their influence on the mixed function oxidase activity (MFO; Benzo(a)pyrene Hydroxylase, Ethoxycoumarine Deethylase). Differences in the elimination rates of diesel soot and particulates from gasoline engines were not found. Compared with the blanc the extracts of diesel soot from two vehicles proved to give a moderate increase of the MFO activity, but a significant difference to the blanc was observed with the extracts of the gasoline engines. It should be mentioned that the effects were studied without taking into account the quantitative relations of the emissions in the ambient air. However, the amounts of particulates were extremely high in relation to the natural conditions. In the limits of our test model there is no indication of a higher toxicity of diesel-emissions.
W
W
Dehnen
R
R
Tomingas
M
M
Kouros
W
W
Mönch
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000378:metabolism*; D006224:Cricetinae; D004790:Enzyme Induction; D005742:Gasoline; D008168:Lung / Q000502:physiology*; D010105:Oxygenases / Q000378:metabolism*; D010316:Particle Size; D010578:Petroleum; D001335:Vehicle Emissions / Q000032:analysis
D005742:Gasoline; D010578:Petroleum; D001335:Vehicle Emissions; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases
Vergleichende Untersuchung zum Verhalten von partikulären Diesel- und Ottomotoremissionen in Tierlungen: Eliminationsrate und Induktion der Benzo(a)pyren Hydroxylase und Ethoxycumarin Deethylase.