Transfer of specificity by murine alpha and beta T-cell receptor genes.
T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.
Dembić
Z
Z
Haas
W
W
Weiss
S
S
McCubrey
J
J
Kiefer
H
H
von Boehmer
H
H
Steinmetz
M
M
D000483:Alleles; D000818:Animals; D010582:Bacteriophage lambda / Q000235:genetics; D001483:Base Sequence; D002460:Cell Line; D002999:Clone Cells; D004274:DNA, Recombinant; D006649:Histocompatibility Antigens / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014158:Transcription, Genetic; D014162:Transfection
D004274:DNA, Recombinant; D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell; D012313:RNA