Ovulation induction with clomiphene and the rise in heterotopic pregnancies. A report of two cases.
Two women were treated for heterotopic pregnancies, the simultaneous occurrence of an intrauterine pregnancy and an ectopic pregnancy. The commonly accepted incidence is 1:30,000. The actual rate appears to be significantly higher; the two most prominent reasons are today's increased rate of ectopic pregnancies and the increased use of clomiphene in infertile women. A rigorous evaluation is required in all early pregnancies in which an ectopic is suspected to rule out the presence of a heterotopic pregnancy.
Department of Obstetrics and Gynecology, Medical College of Pennsylvania, Philadelphia 19129.
M J
MJ
Glassner
E
E
Aron
B A
BA
Eskin
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000628:therapy; D010062:Ovulation Induction; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000453:epidemiology / Q000628:therapy*; D014481:United States / Q000453:epidemiology
D002996:Clomiphene