[The clinical characteristics of treatment-resistant forms of lymphogranulomatosis in children].
Results of treatment of 406 primary cases of Hodgkin's disease aged 2-15 years were retrospectively analysed. Complete remission was registered in 349 (86.0%) patients whereas in 57 (14.0%) partial or no response was observed (resistant forms). The characteristic features of the latter group were: age 10-14 years, short history of disease, primary involvement of the mediastinum, lymphocyte depletion histologic subtype, stage IV, presence of B-symptoms and biologic signs of activity, involvement of mediastinal and bronchopulmonary lymph nodes, 7-9 pathologic sites and bulky (larger than 5 cm in diameter) lesions. Six or more of the above features were observed in 89.5% of resistant patients and as few as 2.6% of complete responders.
Kolygin
B A
BA
Kobikov
S Kh
SKh
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies
Klinicheskie osobennosti rezistentnykh k lecheniiu form limfogranulematoza u deteĭ.