Conformation of two antigenic regions in myelin basic protein.
Four different regions of myelin basic protein from various species have been reported to be the antigenic sites (epitopes) for seven monoclonal antibodies evoked in rats or mice by guinea pig or monkey basic protein. The structures of the epitopes located in the amino-terminal region and in the eight-residue sequence including S-133, were examined by proton n. m. r at 400 MHz in aqueous solutions of peptides obtained by enzymatic cleavage of the rabbit protein. The data suggest conformational similarities between the two regions.
Martenson
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RE
Mendz
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GL
Moore
W J
WJ
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D000939:Epitopes / Q000032:analysis*; D005682:Gadolinium; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D004676:Myelin Basic Protein / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D011487:Protein Conformation; D011817:Rabbits; D013045:Species Specificity
D000939:Epitopes; D004676:Myelin Basic Protein; D010446:Peptide Fragments; C030581:gadolinium oxide; D005682:Gadolinium