[Calcium-transporting system of erythrocytes in psoriasis].
The activity of Ca-ATPase and permeability of erythrocyte membrane for calcium in patients with psoriasis were studied with the aim to reveal disturbances in the calcium membrane transport under psoriasis. In the presence of endogenic activators the mean values of the maximal Ca-ATPase activity of erythrocyte membranes in patients with psoriasis and in healthy people have no essential differences and make up 264 +/- 12 and 244 +/- 10 mumol P/1 cells per 1 min, respectively. The rate of 45Ca accumulation in erythrocytes under inhibition of Ca-ATPase in patients suffering from psoriasis is by 64% higher than in healthy people. The data obtained along with the previously revealed changes in the calcium metabolism in patients with psoriasis make it possible to suppose the presence of the system disturbance of the calcium membrane transport, in particular an increase in the plasma membrane permeability for cells of different types. Such a disturbance may distort a regulatory (messenger) function of calcium ions in the processes of proliferation, differentiation, functional activity and death of different cell types.
I I
II
Mavrov
M S
MS
Goncharenko
V V
VV
Petruniaka
E A
EA
Ereshchenko
A K
AK
Kondakova
L V
LV
Stepaniuk
D001692:Biological Transport; D002118:Calcium / Q000097:blood*; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D011565:Psoriasis / Q000097:blood* / Q000628:therapy
D002118:Calcium
Kal'tsiĭ-transportiruiushchie sistemy v éritrotsitakh pri psoriaze.