[Use of the eye-derived growth factor in the treatment of ulcer of the cornea. A veterinary medicine study in the dog].
A growth factor purified from adult bovine retina and named Eye Derived Growth Factor (EDGF) has been shown to stimulate proliferation of target cells in vitro and in vivo, and to increase the rate of wound healing of experimentally induced corneal ulcers in rabbits. In the present report, dogs (mainly boxers) with chronic recurrent ulcers resistant to various treatments, including chloramphenicol and reputed wound healing drugs, were treated by morning and evening instillations of drops containing 10 stimulation units of EDGF in phosphate buffer saline. Stable healing of the ulcer was obtained in all cases after 12 days of treatment, and no sign of relapse was detected after three months. During the healing period, as well as during the period of increase in cellular proliferation, transitory inflammation accompanied by neovascularization was observed. EDGF represents a new drug for treatment of ulcer.
Muller
G
G
Courty
J
J
Courtois
Y
Y
Clerc
B
B
Barritault
D
D
D000818:Animals; D002908:Chronic Disease; D003315:Cornea / Q000098:blood supply / Q000187:drug effects; D003320:Corneal Ulcer / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009389:Neovascularization, Pathologic; D009883:Ophthalmic Solutions; D012008:Recurrence
D006133:Growth Substances; D009883:Ophthalmic Solutions; C039825:eye-derived growth factor; D005346:Fibroblast Growth Factors
Utilisation du facteur de croissance dérivé de l'oeil dans le traitement des ulcères de cornée. Une étude en médecine vétérinaire chez le chien.