Neuroleptic treatment induces region-specific changes in levels of neurokinin A and substance P in rat brain.
The effects of 10 days treatment with haloperidol or sulpiride on tissue levels of neurokinin A-like and substance P-like immunoreactivity (NKA-LI and SP-LI) in various regions of rat brain were studied using reversed phase HPLC and radioimmunoassay. The most marked effect was a decrease in NKA-LI levels in n.accumbens after treatment with both sulpiride and haloperidol. Striatal NKA-LI and SP-LI levels were not clearly affected. NKA-LI levels but not SP-LI levels were decreased in substantia nigra by haloperidol. A low dose of sulpiride increased both NKA-LI and SP-LI levels in ventral tegmental area/n.interpeduncularis. In conclusion, region-specific changes of NKA-LI and SP-LI were seen after subchronic treatment with neuroleptics. It seems likely that NKA and SP are involved in the neuronal adaptation to the repeated treatment with neuroleptics.
Lindefors
N
N
Brodin
E
E
Ungerstedt
U
U
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D015288:Neurokinin A; D009714:Nucleus Accumbens / Q000378:metabolism; D009928:Organ Specificity; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism; D013469:Sulpiride / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D013373:Substance P; D013469:Sulpiride; D015288:Neurokinin A; D006220:Haloperidol