[Benz(a)anthracene and 2,3,7,8-tetrachloro dibenzo(p)dioxin modulate mitogen-stimulated proliferation of lymphocytes].
The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.
A L
AL
Lozovatskiĭ
V A
VA
Ostashevskiĭ
O M
OM
Perminova
V A
VA
Kozlov
I B
IB
Tsyrlov
D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D001579:Benzopyrene Hydroxylase / Q000032:analysis; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004147:Dioxins / Q000494:pharmacology*; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D001551:Benz(a)Anthracenes; D004147:Dioxins; D037102:Lectins; D000072317:Polychlorinated Dibenzodioxins; D001579:Benzopyrene Hydroxylase
Benz(a)antratsen i 2,3,7,8-tetrakhlordibenzo(p)dioksin modiliruiut mitogenstimulirovannuiu proliferatsiiu limfotsitov.