Isotype-like suppression of T cell-mediated immunity in vivo. II. Suppression of the early component of contact sensitivity by a Ly-2+ T cell-derived suppressor factor that binds to contact sensitivity-initiating, antigen-specific, Ly-1+ T cell-derived factors that are of different antigen specificities.
Recognition that delayed-type hypersensitivity (DTH) reactions, such as contact sensitivity (CS) in mice, are initiated by Ly-1+ T cell-derived, antigen-specific factors has led to identification of a new kind of suppressor T cell that regulates this initiation phase of CS. Regulation by these suppressor T cells is T cell isotype-like in that initiation of DTH of various antigenic specificities is suppressed, whereas, Ly-1+ T cells mediating the antigen/major histocompatibility complex-restricted, classic delayed phase of CS responses are not affected, nor are other T cell activities. This study shows that these isotype-specific suppressor T cells probably act by release of soluble, isotype-specific, suppressor factors. These isotype-specific T cell factors bind to and can be eluted from columns linked with antigen-specific Ly-1+ T cell factors that initiate CS, and are of different antigen specificities. These T cell regulating, anti-isotypic suppressor factors are derived from Lyt-2+ I-J- T cells and suppress CS-initiating T cells, but do not affect the delayed-acting T cells of CS. This is in contrast with antigen-specific T cell suppressor factors that affect the late-acting and not the early-acting T cells of CS. It is suggested that the antigen-binding, CS-initiating, T cell factors, and their regulatory, anti-isotypic T cell factors are, respectively, T cell analogues of immunoglobulin(Ig)E antibody, and IgE-binding factors, that regulate IgE antibody production by IgE+ B cells.
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D000818:Animals; D015478:Antigens, Heterophile; D000950:Antigens, Ly; D003877:Dermatitis, Contact / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D010081:Oxazolone / Q000276:immunology; D010853:Picryl Chloride / Q000276:immunology; D012756:Sheep; D013491:Suppressor Factors, Immunologic / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D013997:Time Factors
D015478:Antigens, Heterophile; D000950:Antigens, Ly; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D013491:Suppressor Factors, Immunologic; D010081:Oxazolone; D010853:Picryl Chloride