Enriched Langerhans cells express more HLA-DR determinants than blood-derived adherent cells (monocytes and dendritic cells).
When used as antigen-presenting cells, enriched Langerhans cells (LC) are known to induce a stronger proliferative T-cell response towards antigens than blood-derived adherent cells (a mixture of monocytes and dendritic cells). To study the mechanism behind this difference in accessory cell function, we have compared the quantitative expression of HLA-DR molecules on LC and adherent cells (AdC), using a radioimmunoassay system. The amount of HLA-DR determinants was calculated to be 50-100 times higher on LC than on AdC.
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Bjercke
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Gaudernack
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Braathen
D000938:Antigen-Presenting Cells / Q000276:immunology; D002448:Cell Adhesion; D000939:Epitopes; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology*; D008221:Lymphoid Tissue / Q000166:cytology*; D009000:Monocytes / Q000276:immunology*
D000939:Epitopes; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II