[Levels of tumor markers (orosomucoid, pregnancy-associated alpha 2-glycoprotein, pregnancy protein-1, placental specific-tissue protein 10, placental specific-tissue protein 12, alpha 1-fetoprotein) in the serum of patients with bronchial carcinoma].
Concentration of orosomucoid, pregnancy associated alpha 2-glycoprotein (alpha 2-PAG), Schwangerschaftsprotein 1 (SP1), placental specific-tissue protein 10 (PP10), placental specific-tissue protein 12 (PP12), alpha 1-Fetoprotein (AFP) were estimated in serum samples of 83 patients with lung cancer of stages II-IV. The proteins were determined by means of the single radial immunodiffusion, the rocket immunoelectrophoresis, the radioimmunoassay and the enzymeimmunoassay. Orosomucoid, PP12 and AFP serum concentrations of the cancer group compared with those of the control group, were increased significantly. Orosomucoid (control group: means = 0.828 g/l; s = 0.301; tumour group: mean = 2.16 g/l; s = 0.862); PP12 (control group: mean = 54.08 micrograms/l; s = 61.70; tumour group: mean = 122.52 micrograms/l; s = 131.16); AFP (control group: mean = 3.05 micrograms/l; s = 3.76; Tumour group: means = 8.29 micrograms/l; s = 17.75). alpha 2-PAG was found only in 37 cases of the tumour group; SP1 in 22 cases. PP10 (control group: mean = 2.25 micrograms/l; s = 0.866; tumour group: mean = 2.503 micrograms/l, s = 1.508). On condition that 2 tested parameters at least were estimated in the pathological range the sensitivity amounted to 0.64 and the specificity to 0.92.
Briese
V
V
Szabo
D G
DG
Than
G N
GN
Willroth
P O
PO
Straube
W
W
D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000097:blood*; D005260:Female; D006023:Glycoproteins; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis*; D011033:Podophyllin / Q000031:analogs & derivatives / Q000032:analysis; D011034:Podophyllotoxin / Q000031:analogs & derivatives; D011257:Pregnancy Proteins / Q000032:analysis*; D000509:alpha-Fetoproteins / Q000032:analysis*
D006023:Glycoproteins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018969:Insulin-Like Growth Factor Binding Proteins; D009961:Orosomucoid; D011257:Pregnancy Proteins; D000509:alpha-Fetoproteins; C003170:mitopodozide; D011033:Podophyllin; D011034:Podophyllotoxin
Zum Verhalten einiger Tumormarker (Orosomukoid, schwangerschaftsassoziiertes alpha 2-Glykoprotein, Schwangerschaftsprotein-1, placental specific-tissue protein 10, placental specific-tissue protein 12, alpha 1-Fetoprotein) im Serum von Patienten mit Bronchialkarzinom.