[Structural and functional interrelations between the liver and endocrine system of the pancreas in disorders of corticosteroid balance].
Experiments on male rats have shown that correlative interrelationships of the liver and endocrine apparatus of the pancreas depend on the content of corticosteroids in the body. The administration of a physiological dose of hydrocortisone raises the synthesis of RNA, phospholipids and glycogen in the liver accompanied by B-insulocyte hypertrophy. Large hormone doses result in the suppression of protein synthesis in hepatocytes with further development of fatty degeneration of the liver and hypofunction of pancreatic islet B-cells. Corticosteroid deficiency causes metabolic derangement of hepatocytes, a rise of the quantity and synthetic activity of pancreatic A-cells which can be corrected by means of hydrocortisone substitution therapy.
Mozheĭko
L A
LA
D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D003900:Desoxycorticosterone / Q000172:deficiency*; D005234:Fatty Liver / Q000209:etiology; D005943:Gluconeogenesis; D006854:Hydrocortisone / Q000172:deficiency*; D006984:Hypertrophy; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats
D008112:Liver Glycogen; D010743:Phospholipids; D003900:Desoxycorticosterone; D012313:RNA; D006854:Hydrocortisone
Strukturno-funktsional'nye vzaimootnozheniia pecheni i endokrinnogo apparata podzheludochnoĭ zhelezy pri narushenii balansa kortikosteroidov.