The influence of copper-dextran complex (C-79), non-steroid anti-inflammatory drugs and bacterial pyrogen on stabilization of rabbit erythrocyte membrane.
We investigated the effect of copper-dextran complex (C-79), acetylsalicylic acid (ASA), mefenamic acid (MEFA) and indomethacin (IND), alone or combined with E. coli lipopolysaccharide (LPS) on osmotic fragility of rabbit erythrocytes. It has been found that LPS in combination with ASA, MEFA, and IND did not change the stabilizing effect of the antipyretics on rabbit erythrocyte membrane. C-79 in doses of 0.4-0.8 mg Cu/kg iv stabilized the erythrocyte membrane for several hours. In lower doses, the compound produced a weak stabilizing effect, and an opposite effect was induced by a dose of 1.6 mg Cu/kg. After administration of C-79 and LPS in combination, the duration of LPS-induced fever was shortened and the erythrocyte stabilization by C-79 was weaker. A combination of ASA with C-79 depressed the body temperature in normothermic animals, while the stabilizing effect of both compounds on the erythrocyte membrane was non-additive.
Debowy
J
J
Obmińska-Domoradzka
B
B
Switała
M
M
Garbuliński
T
T
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D004357:Drug Synergism; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D003911:Dextrans; D008070:Lipopolysaccharides; D011749:Pyrogens; C018905:dextran-2-hydroxy-3-mercaptopropyl ether