Reduced hepatic fatty-acid synthesis and lowered plasma triacylglycerol (TG) in potassium deficient rats.
Potassium deficiency was induced in rats by feeding a potassium- free synthetic diet containing 5% Resonium A. Feeding this diet for 1 week resulted in a decrease of plasma potassium by about 50% vs. pair fed controls. In hypokalemic rats hepatic fatty-acid synthesis and TG secretion by the liver were significantly reduced. In contrast the removal of an intravenous lipid load occurred optimally under this condition. As a consequence plasma TG levels were reduced in potassium-deficient rats.
M
M
Hohenegger
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I
Huber
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H
Schuh
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Echsel
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004032:Diet; D005227:Fatty Acids / Q000096:biosynthesis*; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D011191:Potassium Deficiency / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D014280:Triglycerides; D005934:Glucagon