[Effect of hormonally-induced prolongation of pregnancy in rabbits on maternal and fetal serum lipids].
The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of the mothers and the fetuses was investigated by determination of beta-lipoproteides, triglycerides, cholesterol and HDL- and LDL/VLDL-cholesterol. The most important result is an increase of the concentrations of triglycerides and cholesterol of the fetuses during prolongation of pregnancy. Of the different cholesterol fractions estimated the LDL/VLDL-cholesterol-ratio excellently reflects the changes of the lipid metabolism during prolonged pregnancy.
Ockert
C
C
Willgerodt
H
H
Keller
E
E
Senger
H
H
Pludra
R
R
D000818:Animals; D002715:Chlormadinone Acetate / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL; D005260:Female; D005865:Gestational Age; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D010922:Placenta Diseases / Q000097:blood*; D010927:Placental Insufficiency / Q000097:blood*; D011247:Pregnancy; D011273:Pregnancy, Prolonged; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002715:Chlormadinone Acetate; D002784:Cholesterol
Einfluss einer hormonell erzeugten Ubertragung bei Kaninchen auf die Serumlipide von Muttertieren und Feten.