Voltage-gated Ca2+ current in pancreatic B-cells.
Voltage-dependent inward Ba++ and Ca++ currents were recorded in cultured neonatal rat pancreatic islet cells using the whole-cell voltage clamp technique. Outward current was suppressed by internal Cs+ and ATP and external TEA. Inward currents activated rapidly and decayed to a variable extent. The current decay was particularly marked when using long duration or large depolarizing pulses. Currents were due to Ca++ channel activation since they were abolished by omitting Ba++ and Ca++ or including Co++.
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D000818:Animals; D000831:Animals, Newborn; D001464:Barium / Q000502:physiology; D002118:Calcium / Q000502:physiology*; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology; D007515:Islets of Langerhans / Q000502:physiology*; D051381:Rats
D007473:Ion Channels; D001464:Barium; D002118:Calcium