The cellular basis of haemoglobin switching: further studies of fetal-to-adult haemopoietic cell transplantation.
The switch from fetal to adult hemoglobin synthesis appears to be due to a change in gene expression within the same hemopoietic lineage. The timing of this change looks to be largely determined by the gestational age of the hemopoietic cells, consistent with their containing an intrinsic developmental clock. Precocious switching of fetal cells in an adult environment could reflect an interaction of this clock with external factors or may result from an acceleration of the clock under the extreme experimental conditions, possibly associated with an increased rate of stem cell division.
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D000818:Animals; D002460:Cell Line; D005260:Female; D005319:Fetal Hemoglobin / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006441:Hemoglobin A / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D014714:Vertebrates / Q000254:growth & development*
D006441:Hemoglobin A; D005319:Fetal Hemoglobin