Neovascular glaucoma after helium ion irradiation for uveal melanoma.
Neovascular glaucoma developed in 22 of 169 uveal melanoma patients treated with helium ion irradiation. Most patients had large melanomas; no eyes containing small melanomas developed anterior segment neovascularization. The mean onset of glaucoma was 14.1 months (range, 7-31 months). The incidence of anterior segment neovascularization increased with radiation dosage; there was an approximately three-fold increase at 80 GyE versus 60 GyE of helium ion radiation (23% vs. 8.5%) (P less than 0.05). Neovascular glaucoma occurred more commonly in larger tumors; the incidence was not affected by tumor location, presence of subretinal fluid, nor rate of tumor regression. Fifty-three percent of patients had some response with intraocular pressures of 21 mmHg or less to a combination of antiglaucoma treatments.
M K
MK
Kim
D H
DH
Char
J L
JL
Castro
W M
WM
Saunders
G T
GT
Chen
R D
RD
Stone
D000869:Anterior Eye Segment / Q000098:blood supply*; D004307:Dose-Response Relationship, Radiation; D005901:Glaucoma / Q000209:etiology* / Q000628:therapy; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000628:therapy; D011832:Radiation Injuries; D014604:Uveal Neoplasms / Q000532:radiotherapy*
D006371:Helium