The role of lymphocyte subpopulations in the transfer of rat EAE.
The role of lymphocyte subsets in rat EAE was investigated using a passive transfer system in which spleen cells from sensitized donors were injected into naive recipients after incubation in culture for 72 h with myelin basic protein. The presence of anti-I-A antibody, but not anti-I-E antibody during incubation, prevented disease. In addition, removal of I-A+ cells by rosetting prior to injection eliminated the ability of the donor splenocytes from transferring disease while the simultaneous removal of both cytotoxic/suppressor and B cells had no effect on the disease outcome.
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Brostoff
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Mason
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007114:Immunization; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D004676:Myelin Basic Protein