[The influence on tumor growth and the function of the thiol-dependent systems of the liver of excess cooking fat and vitamin E in the diet. The effects of carminomycin].
A study was made of the influence of excessive culinary fat in the diet containing 30% of trans-isomers and tocopherol on tumor growth, parameters of antitumor and toxic action of carminomycin, and the state of thiol-dependent defensive systems of the liver. The data obtained have evidenced a negative influence of the experimental ration on the survival of the tumor-carriers and on the condition of the normal animals. Activation of the glutathion S-transferase system attended by the exhaustion of the thiol pool in the liver was recorded. Carminomycin toxic action was not modified by the experimental diet.
Tazhibaev
Sh S
ShS
Lenskaia
E G
EG
Alekseeva
N R
NR
Sisemalieva
Zh S
ZhS
Monakhov
B V
BV
D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D002360:Carubicin / Q000627:therapeutic use* / Q000633:toxicity; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004041:Dietary Fats / Q000008:administration & dosage*; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage*
D004041:Dietary Fats; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D002360:Carubicin; D003630:Daunorubicin
Vliianie na opukholevyĭ rost i sostoianie tiolzavisimykh sistem pecheni izbytka kulinarnogo zhira i vitamina E v ratsione. Effekty karminomitsina.