No discriminating power in FPA measurements during fibrinaemia in hip replaced patients generating DVT.
Fibrinaemia following total hip replacement was evaluated in eighteen patients, grouped according to a negative and a positive fibrinogen uptake test (FUT), after having excluded two patients due to a false negative test, using phlebography as reference. The ethanol gelation test (EGT) was employed for detection of circulating soluble fibrin, and the conversion of fibrinogen to fibrin was evaluated by the level of fibrinopeptide A (FPA). Eight patients were cleared with respect to thrombosis, whereas ten had a positive FUT. All patients developed a positive EGT, irrespective of thrombosis, coinciding with the postoperative increase in fibrinogen. FPA increased to approximately twice its preoperative level in both groups of patients, but reached its maximum earlier in patients with thrombosis. However, this parameter had no discriminative value in this type of postoperative thrombosis, possibly due to massive thromboplastin release in both groups.
Nilsen
D W
DW
Holm
B
B
Kierulf
P
P
Ruyter
R
R
Godal
H C
HC
D000368:Aged; D007611:Aprotinin; D005260:Female; D005337:Fibrin / Q000172:deficiency*; D005340:Fibrinogen / Q000032:analysis* / Q000378:metabolism; D005344:Fibrinopeptide A / Q000032:analysis*; D006493:Heparin / Q000627:therapeutic use; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control; D012016:Reference Values; D013924:Thrombophlebitis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D014859:Warfarin / Q000627:therapeutic use
D005344:Fibrinopeptide A; D014859:Warfarin; D005337:Fibrin; D005340:Fibrinogen; D006493:Heparin; D007611:Aprotinin