[Cultured neuroblastoma cells in biochemical studies].
Neuroblastoma is a spontaneous tumour of animals and people. Tumour strains maintained as transplanted tumours and constant cell lines in suspension and monolayer cultures in vitro are obtained. The neuroblastoma cells are able to spontaneous and induced differentiation. The differentiated neuroblastoma cells have many specific properties of nature neurons and are a rather valuable object for solution of many problems in neurochemistry and general cell biology. It is neuroblastoma that has been used to show first the reversibility of neoplastic transformation and to carry out numerous studies to elucidate the mechanisms of cell differentiation. The neuroblastoma cell cultures are a convenient object for studying the ion channels and specifying the role of membrane lipids in their work.
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D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D008954:Models, Biological; D009447:Neuroblastoma / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism
D007473:Ion Channels; D008563:Membrane Lipids; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases
Kul'tura kletok neĭroblastomy v biokhimicheskikh issledovaniiakh.