Antigenic determinants on thyroglobulin recognized by T cells in patients with chronic thyroiditis.
It was found that the proliferating cells to thyroglobulin (Tg) in patients with chronic thyroiditis are confined to a T cell subpopulation. Then, we attempted to characterize the antigenic determinants of Tg recognized by T cells from patients with chronic thyroiditis by Tg-induced DNA-synthetic response. T cells from patients could respond to Tgs from whales, pigs and chickens as well as to human Tg. These findings indicated that epitopes on Tg recognized by T cells were shared by Tgs from various species. In addition, the T cells from different individuals varied in specificity.
Shimojo
N
N
Kohno
Y
Y
Tarutani
O
O
Sasaki
N
N
Nakajima
H
H
D000293:Adolescent; D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D002478:Cells, Cultured; D002908:Chronic Disease; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D008213:Lymphocyte Activation; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology*; D013966:Thyroiditis / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D013954:Thyroglobulin