[Change in levels of specific terminal sugar residues of glycoproteins in sera of patients with complication of diabetes and liver injury].
The concentrations of specific terminal sugar residues of glycoproteins were determined in sera of patients with diabetes, liver injury or complication of both diseases. A significant increase in serum galactose (Gal) concentration was found in all patients. Serum N-acetylneuraminic acid-galactose (NANA-Gal) concentration was significantly decreased in patients with complication of diabetes and liver injury, whereas a high concentration of serum N-acetylneuraminic acid (NANA) was observed only in diabetic patients. Thus the determination of serum Gal and NANA-Gal should be added to one of clinical tests to provide new information on the pathological conditions of diabetes and liver injury.
Nishida
K
K
Department of Biochemistry, School of Hygiene, Fujita Health University, Toyoake.
Nagamura
Y
Y
Ogitsu
N
N
Ishiguro
I
I
Ito
M
M
D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D005693:Galactosemias / Q000097:blood*; D006023:Glycoproteins; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D012794:Sialic Acids / Q000097:blood*
D006023:Glycoproteins; D012794:Sialic Acids