[Pyromecaine--a new anti-arrhythmia preparation improving myocardial blood supply].
Pyromecaine is a local anesthetic used for surface anesthesia. Its marked antiarrhythmic activity has been established in various models of experimental cardiac arrhythmia in doses of 0.1-2.5 mg/kg. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favourable effect on the intracardiac and systemic hemodynamics, on the contractility of the left ventricle and on the myocardial blood flow following the ligation of the coronary artery. Other positive properties of pyromecaine include its anesthetic activity and a relatively low toxicity.
V M
VM
Samvelian
M V
MV
L'vov
N T
NT
Prianishnikova
M A
MA
Varosian
I G
IG
Bagramian
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001282:Atrial Flutter / Q000188:drug therapy; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D002415:Cats; D002642:Chick Embryo; D003326:Coronary Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D011759:Pyrrolidines / Q000627:therapeutic use*; D051381:Rats; D013610:Tachycardia / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D011759:Pyrrolidines; C000661:bumecain
Piromekain--novyĭ antiaritmicheskiĭ preparat, uluchshaiushchiĭ krovosnabzhenie miokarda.