Dominant lethal assay of chlordecone and its distribution in the male reproductive tissues of the rat.
Male rats received 3.6 or 11.4 mg/kg/day of chlordecone orally for 5 days. Some statistically significant events were seen in the reproductive data of females mated to males receiving chlordecone. However, these events did not follow a consistent pattern and do not suggest the conclusion that chlordecone causes dominant lethal effects. Male rats received a single oral dose (40 mg/kg) of chlordecone and were killed at 1, 2, 3, 5, 7, 14 or 21 days. Chlordecone was distributed throughout the reproductive tract. The descending order of concentration was seminal vesicular fluid greater than prostate greater than vas deferens greater than seminal vesicle greater than unwashed sperm greater than washed sperm. It is concluded that chlordecone is well distributed throughout the reproductive tract of the male rat, appears in the ejaculate, and does not appear to produce dominant lethal effects.
G S
GS
Simon
J L
JL
Egle
R W
RW
Dougherty
J F
JF
Borzelleca
D000818:Animals; D007631:Chlordecone / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D005837:Genitalia, Male / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D011467:Prostate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D012669:Seminal Vesicles / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism; D014649:Vas Deferens / Q000378:metabolism
D007306:Insecticides; D007631:Chlordecone