[Hageman factor deficiency (factor XII)--hemorrhage or thrombosis?].
Four generations of a kin with congenital Factor XII deficiency were examined for coagulation and fibrinolysis, with the homozygous female carrier of features with a Factor XII below 1% also revealing certain indications of a disturbed fibrinolysis. The other members of the family had to be evaluated as heterozygous ones, showing values of Factor XII between 40 and 60%. The findings are discussed by referring to data from literature.
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Lutze
D001780:Blood Coagulation Tests; D005175:Factor XII Deficiency / Q000150:complications* / Q000235:genetics; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010375:Pedigree; D013918:Thrombin Time; D013927:Thrombosis / Q000209:etiology*
Hageman-Faktor-Mangel (Faktor XII)--Blutung oder Thrombose?