The effect of hyperdynamic fields on the oxidative metabolism of the paraventricular nucleus.
An important issue in space biology and medicine is understanding the effect of gravitational changes on the mechanisms that regulate fluid homeostasis. The results of this study show that following 7 d exposure to a 2 G or 3 G hyperdynamic field, rats exhibited a linear increase in the cytochrome oxidase staining of neurons in the paraventricular nucleus (PVN). The elevated oxidative metabolism in the PVN suggests that there was an increase in the manufacturing and release of vasopressin into the plasma in response to a perceived hypovolemic condition caused by increased hydrostatic pressure and redistribution of fluid to the periphery. Since vasopressin also has widespread cardiovascular effects, it will be important to understand the relationship between vasopressin and altered gravitational fields.
Murakami
D M
DM
Department of Animal Physiology, University of California, Davis 95616.
Fuller
C A
CA
D000818:Animals; D001810:Blood Volume; D001826:Body Fluids / Q000187:drug effects; D002498:Centrifugation; D006112:Gravitation; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism* / Q000473:pathology; D010953:Plasma Volume; D011311:Pressoreceptors; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014667:Vasopressins / Q000096:biosynthesis* / Q000502:physiology
D014667:Vasopressins