alpha-Fetoprotein and albumin gene expression in brain and other tissues of fetal and adult rats.
Quantitative measurement of messenger RNA (mRNA) for alpha-fetoprotein (AFP) and albumin in developing rat liver and in different fetal and adult tissues reveals a close correlation between the previously determined rate of protein synthesis and mRNA levels. mRNA for AFP and albumin exists in fetal intestine, lung, liver and kidney whereas there are no such transcripts in fetal brain or heart. There are no mRNA transcripts for AFP in any adult organs other than the liver. The lack of mRNA AFP in fetal brain tissue indicates that the AFP found in fetal brain cells is absorbed from the serum. This finding supports the hypothesis that AFP may serve as a carrier protein to deliver bound molecules, such as non-esterified fatty acids, to brain cells at a specific time during development.
Sell
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Longley
M A
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Boulter
J
J
D000418:Albumins / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005786:Gene Expression Regulation; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009928:Organ Specificity; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000235:genetics*
D000418:Albumins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D000509:alpha-Fetoproteins