[Clinical evaluation of prostate antigen (PA) in prostate cancer].
Prostate antigen (PA) which was isolated at 1979 and may have a probability to be a tumor marker of prostate cancer has been evaluated clinically using an EIA for detection method. From mean +3 S.D. of normal male subjects, upper cut-off values of Americans and Japanese have been decided as 2.5 and 1.2 ng/ml, respectively. Of a total of 1,109 assayed serum PA, positive rate in prostate cancer were 78% in Americans (n = 570) and 61% in Japanese (n = 45), whereas false positive rate was lower in Japanese. Serum PA values could be used for speculation of patients' prognosis and monitoring in prostate cancer.
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Kuriyama
D000135:Acid Phosphatase / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D011467:Prostate / Q000201:enzymology; D017430:Prostate-Specific Antigen; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery
D000951:Antigens, Neoplasm; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen