HLA antigens in Asian Indian patients with Graves' disease.
A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.
Tandon
N
N
Department of Endocrinology, All-India Institute of Medical Sciences, New Delhi.
Mehra
N K
NK
Taneja
V
V
Vaidya
M C
MC
Kochupillai
N
N
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006111:Graves Disease / Q000208:ethnology / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006683:HLA-DQ Antigens / Q000032:analysis; D006239:Haplotypes / Q000276:immunology; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006683:HLA-DQ Antigens