Stress, symmetry, and psoriasis: possible role of neuropeptides.
The role of stress as a triggering factor in the exacerbation of psoriasis and the clinically symmetric distribution of psoriatic plaques suggested a possible role for neuropeptides in the etiopathogenesis of psoriasis. Several observations by other investigators involving substance P suggested to us a possible role for substance P as a modulator of the inflammatory response in psoriasis. A hypothesis for the role of substance P that would account for the temporal onset with stress, the clinical symmetry of lesions, and the histopathologic features of psoriasis is presented.
E M
EM
Farber
B J
BJ
Nickoloff
B
B
Recht
J E
JE
Fraki
D004200:Diseases in Twins; D006636:Histamine Release; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D011565:Psoriasis / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000294:innervation; D013004:Somatostatin / Q000502:physiology; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology*; D014430:Twins, Monozygotic
D008222:Lymphokines; D009419:Nerve Tissue Proteins; D013373:Substance P; D013004:Somatostatin