Different effects of local anesthetics on calcium influx into rat mast cells.
Lidocaine, W49091, procaine and benzocaine inhibited mast cell secretion induced by concanavalin A and A23187. They inhibited Ca influx stimulated by concanavalin A, suggesting that they inactivate Ca channel of mast cells. Lidocaine and procaine inhibited Ca influx stimulated by A23187, but W49091 and benzocaine did not.
Ohishi
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Suzuki
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Uchida
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D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001566:Benzocaine / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008012:Lidocaine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D008567:Membranes, Artificial; D011343:Procaine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000779:Anesthetics, Local; D008567:Membranes, Artificial; C014672:N-methyllidocaine; D011343:Procaine; D008012:Lidocaine; D002118:Calcium; D001566:Benzocaine