Immunocytochemical detection of peptides in the guinea pig cochlea.
The cochleae of juvenile guinea pigs were investigated for the presence of several neuropeptides. Glucagon, insulin, CCK and beta-endorphin immunoreactive neurons and nerve fibers as well as hair cells were demonstrated by the peroxidase antiperoxidase technique. Small amounts of substance P were also found in different sites in the inner ear. In contrast, prolactin-like material could not be found at all. These findings have significance with regard to the putative role of neuropeptides in neuromodulation.
R
R
Nowak
A
A
Dorn
H G
HG
Bernstein
A
A
Rinne
H J
HJ
Scholtz
M
M
Ziegler
D000818:Animals; D002766:Cholecystokinin / Q000032:analysis; D003051:Cochlea / Q000032:analysis*; D004723:Endorphins / Q000032:analysis; D005934:Glucagon / Q000032:analysis; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000032:analysis; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000032:analysis; D009412:Nerve Fibers / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009474:Neurons / Q000032:analysis; D011388:Prolactin / Q000032:analysis; D013373:Substance P / Q000032:analysis; D001615:beta-Endorphin
D004723:Endorphins; D007328:Insulin; D009419:Nerve Tissue Proteins; D013373:Substance P; D001615:beta-Endorphin; D011388:Prolactin; D005934:Glucagon; D002766:Cholecystokinin