Lectin distinction of benign from malignant histiocytes.
Ricinus communis agglutinin (RCA) staining of malignant histiocytosis (two cases) and tissue infiltrates of monoblastic leukemia revealed two distinct macrophage-histiocyte types: one with cytoplasmic staining (RCA+), the other without (RCA-). RCA+ cells corresponded to benign-appearing histiocytes without nuclear atypia, whereas RCA-cells were cytologically malignant. In one case of malignant histiocytosis, many RCA-tumor cells were surrounded by a thin cytoplasmic extension of RCA+ cells, which suggested an interaction between the tumor cells and stromal macrophage-histiocytes. These observations support the view that most benign-appearing histiocytes in malignant histiocytosis are reactive in nature and suggest that RCA staining can be useful in distinguishing between benign and malignant disorders of macrophage-histiocytes.
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Kadin
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D037102:Lectins; D007948:Leukemia, Monocytic, Acute / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D037121:Plant Lectins; D013194:Staining and Labeling
D037102:Lectins; D037121:Plant Lectins; C017707:Ricinus communis agglutinin-1