Etoposide, methotrexate, and bleomycin in drug-resistant gestational trophoblastic disease.
Nine patients with gestational trophoblastic disease resistant to multiagent chemotherapy, CHAMOCA, received methotrexate, bleomycin, and etoposide (VP 16-213) combination therapy. Eight patients achieved complete remission. There was no drug-related death. The importance of vigilant search and prevention of sepsis was emphasized. Alternative combination chemotherapy for drug-resistant choriocarinoma was discussed.
Wong
L C
LC
Choo
Y C
YC
Ma
H K
HK
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*
D001761:Bleomycin; D005047:Etoposide; D008727:Methotrexate