Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16.
Genomic Southern blots of mouse-hamster somatic cell hybrids were analyzed with a probe prepared from a cDNA encoding murine Mx protein, the product of the interferon-regulated influenza virus resistance allele Mx+. Results of this analysis indicate that the Mx gene is located on mouse chromosome 16. In appropriate backcross mice, no linkage was observed between Mx and md, a marker previously mapped close to the centromere of chromosome 16, suggesting a more distal localization of Mx.
Staeheli
P
P
Pravtcheva
D
D
Lundin
L G
LG
Acklin
M
M
Ruddle
F
F
Lindenmann
J
J
Haller
O
O
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D005260:Female; D005796:Genes; D007372:Interferons / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000235:genetics*
D007372:Interferons