Studies on monovalent anaphylactogens with carbohydrate auxiliary groups: exclusion of an artefact.
N1-DNCP-N6-lactobionoyl-1,6-hexanediamine is an elicitor of anaphylactic reactions in the guinea pig passively sensitized by antisera raised with a DNCP-bovine gammaglobulin conjugate. If the antisera contained anticarbohydrate antibodies against the carbohydrate residues of the globulin, significantly cross-reacting with the lactobionoyl moiety, anaphylactogenic cell triggering would be by classical hetero-specific bridging which involved the DNCP- and the lactobionoyl residues as ligands. This possibility was excluded by showing that a bis-lactobionoyl conjugate is unable to elicit anaphylactic reactions.
Guenin
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R
Schneider
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CH
D000485:Allergens; D000818:Animals; D004136:Dinitrobenzenes / Q000276:immunology*; D004187:Disaccharides / Q000276:immunology*; D000939:Epitopes; D006168:Guinea Pigs; D006241:Haptens; D007783:Lactones; D009578:Nitrobenzenes / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D012710:Serum Albumin, Bovine / Q000276:immunology
D000485:Allergens; D004136:Dinitrobenzenes; D004187:Disaccharides; D000939:Epitopes; D006241:Haptens; D007783:Lactones; D009578:Nitrobenzenes; D012710:Serum Albumin, Bovine; C005608:lactobionic acid; C047110:N(1)-2-carboxy-4,6-dinitrophenyl-N(6)-lactobionoyl-1,6-hexanediamine