Neurochemical changes in the brain and spinal cord of sheep: a basis for the immobilizing action of etorphine.
Clinical and pharmacological analyses showed a full immobilizing action of etorphine in adult sheep +/- 7 min. after a deep i.m. injection of the drug at a dosage rate of 20 micrograms/kg. Neurochemical analyses of motoric CNS-structures done within 30 min. after i.m. injection of etorphine in an immobilizing dose, showed the following: A significant decrease of dopamine (DA) and homovanilic acid (HVA) concentrations in the corpus striatum, the frontal motor cortex, cerebellum and in the lumbo-sacral portion of the spinal cord. A decrease of DA-concentration with a simultaneous increase of HVA-concentration in the pons. A significant decrease of noradrenaline (NA) concentration in the cerebellum and lumbo-sacral portion of the spinal cord and an insignificant decrease of amine concentration in the pons. A significant increase of adrenaline (A) concentration in the frontal motor cortex. A significant decrease of 5-hydroxytryptamine (5-HT) concentration in the frontal motor cortex and cerebellum and an equally significant increase in its concentration in the pons.
Kania
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D000818:Animals; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D004837:Epinephrine / Q000032:analysis; D005048:Etorphine / Q000494:pharmacology*; D005260:Female; D006719:Homovanillic Acid / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007103:Immobilization; D009019:Morphinans / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D011149:Pons / Q000032:analysis / Q000187:drug effects; D012701:Serotonin / Q000032:analysis; D012756:Sheep / Q000378:metabolism* / Q000502:physiology; D013116:Spinal Cord / Q000032:analysis* / Q000187:drug effects
D009019:Morphinans; D012701:Serotonin; D005048:Etorphine; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine