[Immune response and immune tolerance to the O-antigen of Shigella flexneri VI].
The method for the determination of the number of cells synthetizing antibodies to S. flexneri VI O-antigen in the spleen of mice has been developed. Primary immune response to this antigen has been studied with the use of the new method. Immune response to the optimum immunogenic dose of O-antigen has a manifest variable character. The intensity of primary immune response has been shown to rise with the increase of the dose of O-antigen from 0.004 to 50 micrograms. The preliminary injection of 200 micrograms of O-antigen, followed by the injection of cyclophosphamide 2 days later, leads to the development of specific immunological tolerance to O-antigen in experimental animals.
Rubakova
E I
EI
Ermakov
G P
GP
Fontalin
L N
LN
Nesterenko
V G
VG
Belaia
Iu A
IuA
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D000942:Antigens, Bacterial / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D019081:O Antigens; D012763:Shigella flexneri / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000942:Antigens, Bacterial; D019081:O Antigens; D003520:Cyclophosphamide
Immunnyĭ otvet i immunologicheskaia tolerantnost' k O-antigenu Shigella flexneri VI.