Allogeneous transplantation of the mitral valve. An open question.
To overcome the disadvantages of mechanical valves and bioprostheses, especially in the mitral position, transplantation of an allogeneous mitral valve was performed in 3 patients. One transplant had to be removed 8 weeks postoperatively, most probably due to maladjustment of the anterior leaflet during surgery. The histology of this specimen showed not clear signs of rejection. In 2 patients, echocardiography showed a normal motion pattern of the mitral valves 6 months postoperatively. Regurgitation was less than 10% of the total stroke volume as calculated by videodensitometry. Both patients were in excellent clinical condition. Mitral valve transplantation can be performed with excellent short-term results. Further studies including immunologic monitoring are necessary to evaluate the long-term behavior of the transplant.
Sievers
H H
HH
Lange
P E
PE
Yankah
A C
AC
Wessel
A
A
Bernhard
A
A
D000328:Adult; D004452:Echocardiography; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology / Q000637:transplantation*; D008946:Mitral Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D013997:Time Factors; D014184:Transplantation, Homologous