Techniques for assessing inotropic effects of drugs in patients with heart failure: application to the evaluation of nicardipine.
Evaluation of new drugs for the treatment of patients with heart failure requires assessment of the inotropic effects of these agents. Use of traditional indexes of contractility has been limited by the confounding effects of load on these measures of contractile function, although they have yielded meaningful conclusions in some studies. Recently, the end-systolic pressure volume relation (ESPVR) has emerged as a relatively load-independent measure of contractility. Because it is difficult to construct the relation in the clinical setting, several approximations have been introduced, some of which have significant limitations. We have applied the ESPVR to the assessment of the inotropic effect of the new dihydropyridine calcium channel blocker, nicardipine, in 15 patients with heart failure caused by systolic dysfunction. We constructed left ventricular pressure-volume loops from micromanometer pressure and radionuclide volume and manipulated afterload with nitroprusside. In response to intravenous nicardipine, mean arterial pressure fell from 91 +/- 4 (mean +/- SEM) to 72 +/- 2 mm Hg, left ventricular end-diastolic pressure fell from 27 +/- 2 to 23 +/- 3 mm Hg, cardiac index increased from 1.7 +/- 0.1 to 2.4 +/- 0.1 L/min/m2, and left ventricular ejection fraction increased from 0.15 +/- 0.01 to 0.19 +/- 0.01 (all p less than 0.05). Heart rate did not change. A rightward shift of the ESPVR, indicating a negative inotropic effect of nicardipine, was observed in 12 of 14 patients (p less than 0.05). We conclude that nicardipine improves left ventricular pump performance despite its negative inotropic effect in patients with severe heart failure. The improvement in pump performance can be attributed to afterload reduction.
Department of Medicine, Massachusetts General Hospital, Boston 02114.
M A
MA
Fifer
C N
CN
Aroney
M J
MJ
Semigran
H C
HC
Herrmann
G W
GW
Dec
C A
CA
Boucher
D000368:Aged; D001794:Blood Pressure; D001810:Blood Volume; D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006334:Heart Function Tests; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009529:Nicardipine / Q000627:therapeutic use*; D013599:Systole
D009529:Nicardipine