A BF subtype "Fb1" is a marker gene of some Mongoloid populations.
A factor B subtype, BF*Fb1, was first detected in Japanese by using isoelectric focusing or agarose gel electrophoresis in Tris/glycine/Veronal buffer. Our previous studies suggested that BF*Fb1 may be characteristic of some of Mongoloid populations. To investigate further distribution of BF*Fb1, samples randomly collected from Japanese in Yonaguni island of Japan and Cambodian were tested. BF*Fb1 was not observed in a Cambodian population whereas in a Japanese population of Yonaguni island, BF*Fb1 occurred at a frequency five times as high as those in main islands of Japan. In paternity cases, a Korean family with three offsprings was shown to transmit BF*Fb1 from the accused man to one of the offsprings. These data strongly indicate that BF*Fb1 is a marker gene for some of Mongoloid populations.
Department of Legal Medicine, Osaka Medical College, Japan.
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Suzuki
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Mutoh
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Cey-Bert
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Ito
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Matsumoto
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002160:Cambodia; D003175:Complement C2 / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D011415:Complement Factor B / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D004792:Enzyme Precursors / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D007723:Korea; D010375:Pedigree; D011110:Polymorphism, Genetic; D011897:Random Allocation
D003175:Complement C2; D003181:Complement C4; D004792:Enzyme Precursors; D005819:Genetic Markers; D011415:Complement Factor B