Ancylostoma ceylanicum: ATP production and effect of anthelmintics.
Dicarboxylic acids and a few amino acids were found to support mitochondrial phosphorylation in A. ceylanicum. Anaerobiasis markedly reduced this activity. Maximum effect was observed on succinate supported phosphorylation which in anaerobic atmosphere yielded only 2% ATP compared to that in the presence of air. Known as well as candidate anthelmintics significantly inhibited ATP formation. Mebendazole, amongst them, registered greatest effect. Oxygen consumption by the mitochondria exhibited poor response to the action of anthelmintics other than praziquantel.
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
V M
VM
Srivastava
N
N
Agarwal
P K
PK
Visen
J C
JC
Katiyar
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000722:Ancylostoma / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D000871:Anthelmintics; D000255:Adenosine Triphosphate