Expression of low molecular weight cytokeratin proteins in cervical neoplasia.
CAM 5.2 is a monoclonal antibody which identifies lower molecular weight cytokeratin proteins (50, 43 and 38 kD). It is an antibody which works reliably on formalin-fixed, paraffin-embedded tissues. In this study, using CAM 5.2 in the indirect immunoperoxidase method we have examined ectocervical epithelium ranging from normal, through metaplasia and cervical intraepithelial neoplasia to invasive squamous carcinoma. CAM 5.2 is demonstrated to be a useful indicator of changes associated with malignant transformation in the ectocervix.
L G
LG
Bobrow
C A
CA
Makin
S
S
Law
W F
WF
Bodmer
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000473:pathology; D002584:Cervix Uteri / Q000032:analysis / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D008970:Molecular Weight; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000473:pathology
D000911:Antibodies, Monoclonal; D007633:Keratins