Effect of hemorrhagic and nortriptyline-induced shock on the porcine pancreas as evaluated by changes in serum cationic trypsin-like immunoreactivity.
Hemorrhagic shock caused by gastrointestinal bleeding in seven pigs and by external bleeding in another six pigs and cardiogenic shock induced by intravenous infusion of the tricyclic antidepressant drug nortriptyline in yet another eight pigs caused a significant increase in serum cationic trypsin-like immunoreactivity together with formation of complexes between cationic trypsin, on the one hand, and alpha-2-macroglobulin and alpha-1-antitrypsin, on the other hand, compatible with what happens in acute pancreatitis.
Florholmen
J
J
Revhaug
A
A
Burhol
P G
PG
Lundgren
T I
TI
Giercksky
K E
KE
D000818:Animals; D002412:Cations / Q000378:metabolism; D005260:Female; D008297:Male; D009661:Nortriptyline; D010179:Pancreas / Q000378:metabolism*; D011863:Radioimmunoassay; D012770:Shock, Cardiogenic / Q000097:blood* / Q000139:chemically induced; D012771:Shock, Hemorrhagic / Q000097:blood*; D013552:Swine; D014357:Trypsin / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D002412:Cations; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D009661:Nortriptyline; D014357:Trypsin