The effect of isovolaemic haemodilution on infection-related serum protein levels.
Approximately 25% of blood was replaced by either hydroxyethyl starch (mol. wt 450,000), dextran (mol. wt 60,000), or 5% plasma protein solution, 24 h prior to a surgical intervention. Twenty-four adult patients were studied and haematocrit, total protein, plasma albumin, alpha-1-antitrypsin, IgG, IgM, antithrombin III, fibronectin and alpha-2-macroglobulin were determined. The resulting blood concentrations suggest that the various replacement solutions exert only a dilutional effect upon the proteins studied. Furthermore, there is no difference regarding the course of the various infection-related proteins whether plasma protein solution or synthetic colloids are used for blood replacement. The decrease of the studied proteins during the study period does not exceed 35% of the control value. This is not considered to be a clinically significant reduction and levels of infection-related proteins were not dangerously low.
Lackner
F X
FX
Graninger
W
W
Khosropour
R
R
D000328:Adult; D000805:Angiotensin III / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D005353:Fibronectins / Q000378:metabolism; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000008:administration & dosage; D013530:Surgical Wound Infection / Q000097:blood*; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000378:metabolism
D001798:Blood Proteins; D005353:Fibronectins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010952:Plasma Substitutes; D000511:alpha-Macroglobulins; D000805:Angiotensin III