The effect of timolol, betaxolol, and placebo on corneal sensitivity in healthy volunteers.
This study in sixty healthy volunteers investigated the effect of a single drop of either 0.5% timolol ophthalmic solution, 0.5% betaxolol ophthalmic solution, or placebo on corneal sensitivity as measured by the Cochet-Bonnet anesthesiometer. Corneal sensitivity was measured immediately prior to the drop and then 1, 3, 6, 10, 15 and 30 minutes after drop instillation. The timolol treated eyes showed a significant decrease at one minute after instillation. An increase in sensitivity occurred in the placebo group at 15 and 30 minutes. In the eyes treated with betaxolol, a significant reduction in corneal sensitivity was seen at every time point through the 10-minute measurement.
Department of Clinical Research, Merck Sharp & Dohme Research Laboratories, West Point, PA.
R
R
Vogel
C M
CM
Clineschmidt
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H
Hoeh
S F
SF
Kulaga
R W
RW
Tipping
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D015784:Betaxolol / Q000008:administration & dosage / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012684:Sensory Thresholds / Q000187:drug effects; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*
D013999:Timolol; D015784:Betaxolol