Human schistosomiasis: deficiency of large granular lymphocytes and indomethacin-sensitive suppression of natural killing.
Twenty-eight children infected with Schistosoma haematobium and S. mansoni were tested for natural killer (NK) cell activity in vitro using the myeloid/erythroid cell line K562 as target. In addition, the frequency of large granular lymphocytes (LGL) and the number of HNK-1+ lymphocytes were examined in peripheral blood. NK cell activity was found to be markedly reduced in most patients when compared with a group of healthy Caucasian individuals (P less than 0.005). Moreover, the impairment of NK activity clearly correlated with the intensity of infection, which was quantified by parasite ova excretion in stool and urine. Within the lymphocyte compartment the percentages of cells with the NK phenotype (HNK-1+) were found to be normal, although the majority of patients exhibited decreased numbers of LGL (P less than 0.005). The absolute and relative frequencies of LGL and HNK-1+ lymphocytes by no means correlated with the parasite load. In vitro results suggest an at least partly prostaglandin-mediated and interferon-resistant functional defect of NK cells.
G A
GA
Gastl
H
H
Feldmeier
C
C
Kortmann
A A
AA
Daffalla
H H
HH
Peter
D002648:Child; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000503:physiopathology*; D008214:Lymphocytes / Q000145:classification*; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000473:pathology
D007372:Interferons; D007213:Indomethacin