DNA adducts as markers of exposure in hazardous waste workers.
The interaction of a chemical or physical agent with DNA, resulting in the formation of covalent adducts or other modifications, has been implicated in the carcinogenic process for certain classes of chemicals. Demonstration of modified DNA may be taken as evidence of the interaction of a genotoxic agent with DNA, which is the basis for this review of DNA adducts as markers of exposure in hazardous waste work.
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.
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McDiarmid
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Strickland
D014408:Biomarkers, Tumor / Q000097:blood*; D004784:Environmental Monitoring / Q000379:methods*; D005819:Genetic Markers / Q000097:blood*; D006256:Hazardous Waste; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000139:chemically induced; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced
D014408:Biomarkers, Tumor; D005819:Genetic Markers; D006256:Hazardous Waste