Recombinant human interferons.
The genes for several human interferons (IFN) alpha, of IFN beta and IFN gamma have been cloned and expressed in bacterial cells. Recombinant interferons have been purified from these cells and shown to be as biologically active as their natural counterparts. The expression systems, purification schemes and the biochemical properties of these interferons are discussed.
Otto
B
B
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D003001:Cloning, Molecular; D005814:Genes, Viral; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology; D007371:Interferon-gamma / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology; D007372:Interferons / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology; D008970:Molecular Weight; D010446:Peptide Fragments / Q000302:isolation & purification; D011994:Recombinant Proteins / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology
D007370:Interferon Type I; D010446:Peptide Fragments; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007372:Interferons