Novel 2',5'-oligoadenylates synthesized in interferon-treated, vaccinia virus-infected cells.
2-5A[ppp(A2'p)nA] and related materials accumulate to greater than micromolar concentrations in vaccinia virus-infected HeLa cells and in interferon-treated, vaccinia-infected HeLa, CV1, and L929 cells even when virus replication is not inhibited. A variably complex mixture of authentic 2-5A (n = 2 to 4), nonphosphorylated cores [(A2'p)nA; n = 2 to 5], and additional compounds of unknown structure was observed.
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D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000818:Animals; D002478:Cells, Cultured / Q000382:microbiology; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D009843:Oligoribonucleotides / Q000096:biosynthesis*; D014615:Vaccinia / Q000378:metabolism*; D014616:Vaccinia virus
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D007372:Interferons