[Tha fatty acid spectrum of the thrombocyte phospholipids in experimental diabetes mellitus complicated by proteinuria].
Experiments on 5 test and 16 control Wistar-Kyoto rats have shown that streptozocin diabetes mellitus complicated by proteinuria is characterized by the following changes of the fatty acid spectrum of platelet phospholipids: a decrease in the content of C18:2p6, C18:3p3, C20:4p6, C20:3p9, C20:5p3, in the sum of fatty acids of the linoleic group and the ratio of unsaturated/saturated fatty acids and an increase in the content of C18:0, C20:2p6 and C20:3p6. These changes were accompanied by an increase in the platelet aggregation ability, an increase in their synthesis of thromboxane A2 and a decrease in the synthesis of prostacyclin I2 by vascular endothelium and account for them, to a certain degree. The obtained results are promising with relation to achieving a positive effect of the diets, rich in linoleic acid, for prophylaxis of vascular complications in diabetes mellitus.
Bondar'
V I
VI
Avakian
T Iu
TIu
Zadkova
G F
GF
Markov
Kh M
KhM
D000818:Animals; D001792:Blood Platelets / Q000032:analysis*; D002849:Chromatography, Gas; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications; D005227:Fatty Acids / Q000097:blood* / Q000302:isolation & purification; D008297:Male; D010743:Phospholipids / Q000097:blood* / Q000302:isolation & purification; D011507:Proteinuria / Q000097:blood* / Q000209:etiology; D051381:Rats; D011921:Rats, Inbred WKY
D005227:Fatty Acids; D010743:Phospholipids
Zhirno-kislotnyĭ spektr fosfolipidov trombotsitov pri éksperimental'nom sakharnom diabete, oslozhnennom proteinurieĭ.