Effects of steel mutation on spermatogenesis stimulated by fetuin.
The effect of the steel mutation on spermatogenesis was investigated using organ culture. Cultured cryptorchid testes from WB-+/+ mice showed an effective differentiation of type A spermatogonia in response to Pedersen type III fetuin. In contrast, the cryptorchid testes from WB-S1/+ showed neither differentiation nor division of type A spermatogonia. The findings reported here are the first demonstration of retarded response of steel mutation on a well-known agent, fetuin.
Nishimune
Y
Y
Haneji
T
T
Maekawa
M
M
Sakamaki
K
K
Kitamura
Y
Y
D000483:Alleles; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003456:Cryptorchidism / Q000503:physiopathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D009924:Organ Culture Techniques; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000254:growth & development; D000509:alpha-Fetoproteins / Q000494:pharmacology*
D000509:alpha-Fetoproteins