Selective hippocampal lesion following omega-conotoxin administration in rats.
Histopathological evaluation of rat brains 3 days following unilateral i.c.v. injections of omega-conotoxin GVIA (omega-ctx), 0.032 and 0.1 nmol/kg, was performed. An isolated unilateral lesion confined to the injected hemisphere was found in the hippocampal CA3 neurons. Morphometric analysis of these cells revealed a significant reduction in cell area in both dose groups compared to i.c.v. injected vehicle, and to the contralateral hemisphere. These data indicate a specific degenerative process and suggest that CA3 cells possess omega-ctx-sensitive Ca2+ channels which are essential to their viability.
Department of Neurology, Uniformed Services University, Bethesda, MD 20814.
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Shapira
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Kadar
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Adeymo
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Feuerstein
D000818:Animals; D002121:Calcium Channel Blockers / Q000633:toxicity; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology*; D007839:Functional Laterality; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000633:toxicity*; D011712:Pyramidal Tracts / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D010456:Peptides, Cyclic; D020866:omega-Conotoxin GVIA