Beta 1 and beta 2 adrenergic receptors: their role in the regulation of paradoxical sleep in the rat.
The influences of beta adrenergic transmission on the regulation of paradoxical sleep (PS) were analysed in the rat. Pharmacological experiments have used beta 1,2 as well as preferential beta 1 or beta 2 compounds. The blockade of the beta 1 adrenoceptors induced a dose-related PS decrease, and stimulation of these preblocked receptors prevented this PS insomnia. SWS was generally not affected. It is concluded that beta 1 neurotransmission is directly involved in the regulation of PS.
L
L
Lanfumey
C
C
Dugovic
J
J
Adrien
D000070:Acebutolol / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D011217:Practolol / Q000031:analogs & derivatives; D011294:Prenalterol; D011433:Propranolol / Q000494:pharmacology; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D011814:Quipazine; D000070:Acebutolol; D011433:Propranolol; D007545:Isoproterenol; D011294:Prenalterol; D011217:Practolol; D002976:Clenbuterol