Assignment by in situ hybridization of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene.
A 1.8 kb human cDNA probe for angiotensinogen (renin substrate) was used to determine the chromosomal location of the angiotensinogen gene by in situ hybridization. The results show that human chromosome region 1q4 contains the angiotensinogen gene. The human renin gene has also recently been assigned to the same band of chromosome 1. Thus, the angiotensinogen and renin genes are located in the same region of chromosome 1.
INSERM U 36, Collège de France, Paris.
I
I
Gaillard-Sanchez
M G
MG
Mattei
E
E
Clauser
P
P
Corvol
D000808:Angiotensinogen / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D012083:Renin / Q000235:genetics*
D015342:DNA Probes; D000808:Angiotensinogen; D004247:DNA; D012083:Renin