Location of 'continuous' antigenic determinants in the protruding regions of proteins.
A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.
J M
JM
Thornton
M S
MS
Edwards
W R
WR
Taylor
D J
DJ
Barlow
D000939:Epitopes / Q000032:analysis*; D006422:Hemerythrin / Q000031:analogs & derivatives / Q000276:immunology; D008958:Models, Molecular; D009113:Muramidase / Q000276:immunology; D009211:Myoglobin / Q000276:immunology; D010860:Pigments, Biological / Q000276:immunology; D011487:Protein Conformation; D011506:Proteins / Q000276:immunology*; D013499:Surface Properties
D000939:Epitopes; D006422:Hemerythrin; D009211:Myoglobin; D010860:Pigments, Biological; D011506:Proteins; C008571:myohemerythrin; D009113:Muramidase