Auditory brain-stem evoked potentials in patients undergoing dialysis.
Auditory brain-stem evoked potentials (ABEPs) and pure-tone audiograms were obtained for 38 patients with renal failure, undergoing dialysis, before and after a dialysis session, and for 40 healthy normal subjects. Blood chemistry was also evaluated for each patient before and after dialysis. ABEP abnormality (using 10/sec click rate) was observed for 24% of the patients, rising to 44% when 55/sec measures were included. Abnormalities included prolongations of peak latencies for both click rates, and prolongation of interpeak latency differences. Pre-dialysis calcium was significantly different between patients with or without ABEP abnormality. In addition to this chronic effect on ABEPs, an acute effect of the dialysis session was found. Blood chemistry data, ABEP latencies and I-III interpeak latency differences were significantly different before, as compared to after dialysis. The acute effect of dialysis on blood calcium levels correlated with its effect on latencies of peaks III and V at 10/sec click rate, and on peaks I and V latency at 55/sec. These results may indicate the types of dysfunction revealed by increased stimulus rate measures.
Pratt
H
H
Brodsky
G
G
Goldsher
M
M
Ben-David
Y
Y
Harari
R
R
Podoshin
L
L
Eliachar
I
I
Grushka
E
E
Better
O
O
Garty
J
J
D001307:Auditory Perception / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology*; D002118:Calcium / Q000097:blood; D005072:Evoked Potentials, Auditory; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology*; D006435:Renal Dialysis
D002118:Calcium