Drug-induced alterations in muscle tissue oxygen pressure in patients with arterial occlusive disease.
Muscle tissue oxygen pressure fields were examined on the surface of the gastrocnemius muscle of 17 patients with peripheral arterial occlusive disease before and during intra-arterial administration of dextran 40 50 ml/50 min, xantinolnicotinate 600 mg ad 50 ml NaCl 0.9%/50 min and prostaglandin E1 1.0-2.5 ng/kg/min ad 50 ml NaCl 0.9%/50 min. Median PO2 increased in 6 out of 7 patients up to 214% when dextran 40 was given and up to 300% in all 5 cases who received prostaglandin E1. In some patients the histograms' distribution type changed during the treatment from a scattered form which indicates microcirculatory disorders to a bell-shaped form which is expected when microcirculation is undisturbed. Intra-arterial administration of xantinolnicotinate was without any influence on poststenotic muscle PO2. The registration of muscle tissue oxygen pressure fields is an ideal method for determining the effect of so called vasoactive drugs in treatment of peripheral arterial occlusive disease.
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Creutzig
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K
Alexander
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000494:pharmacology; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D003911:Dextrans / Q000494:pharmacology; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply*; D010100:Oxygen / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D014971:Xanthinol Niacinate / Q000494:pharmacology
D003911:Dextrans; D014971:Xanthinol Niacinate; D000527:Alprostadil; D010100:Oxygen