Differences in microbicidal activities of human macrophages against Toxoplasma gondii and Trypanosoma cruzi.
The microbicidal activities of normal human pelvic macrophages against infection by the intracellular protozoa Toxoplasma gondii and Trypanosoma cruzi were examined. Macrophages allowed infection by T. gondii and yet possessed remarkable microbicidal activity against this organism. In contrast, human macrophages were not microbicidal against T. cruzi.
Israelski
D M
DM
Department of Obstetrics and Gynecology, Palo Alto Medical Clinic, California.
Araujo
F G
FG
Wachtel
J S
JS
Heinrichs
L
L
Remington
J S
JS
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D014122:Toxoplasma / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology*