[Reactivation of the alpha 1-fetoprotein synthesis in systemic lupus erythematosus].
Serum concentrations of AFP have been determined in patients suffering from systemic lupus erythematosus (SLE) or other "collagenoses" using fluorescence ELISA adapted to the chamber analytical technique. 20% of the SLE patients showed elevated AFP levels (range 30-233 ng/ml), some of them repeatedly. Only 2 of the 14 patients without SLE had AFP levels above 30 ng/ml (37 resp. 40 ng/ml). In SLE sera there was a significant correlation of raised AFP to higher anti-dsDNA antibody concentrations (Mann-Whitney U-test: p = 0.042). The mean dosage of azathioprin and prednisone in patients with SLE did not significantly differ from the non-SLE group. We discuss the possible reactivation of AFP synthesis on account of SLE itself.
U
U
Wollina
M
M
Schulze
B
B
Knopf
D000410:Alanine Transaminase / Q000097:blood; D000906:Antibodies / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001379:Azathioprine / Q000494:pharmacology; D004247:DNA / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy; D009220:Myositis / Q000097:blood; D011241:Prednisone / Q000494:pharmacology; D012595:Scleroderma, Systemic / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis*
D000906:Antibodies; D000509:alpha-Fetoproteins; D004247:DNA; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001379:Azathioprine; D011241:Prednisone
Reaktivierung der Alpha 1-Fetoproteinsynthese beim systemischen Lupus erythematodes.