The electrophoretic analysis of low molecular weight nucleic acids from Crohn's disease tissues in the search for an unconventional small infectious agent. Brief report.
A small unconventional, viroid-like aetiological agent might initiate Crohn's disease (CD). Electrophoresis of radiolabelled low molecular weight nucleic acids from mesenteric lymph nodes and leucocytes did not distinguish CD-specific sequences compatible with a viroid-like agent.
Butcher
P D
PD
McFadden
J J
JJ
Hermon-Taylor
J
J
D001345:Autoradiography; D003424:Crohn Disease / Q000378:metabolism / Q000382:microbiology*; D004247:DNA / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007962:Leukocytes / Q000032:analysis; D008198:Lymph Nodes / Q000032:analysis; D008970:Molecular Weight; D009696:Nucleic Acids / Q000032:analysis*; D012313:RNA / Q000032:analysis; D014772:Viroids / Q000302:isolation & purification*
D009696:Nucleic Acids; D012313:RNA; D004247:DNA