Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines.
A double-stranded RNA unwinding and modifying activity was found to be present in a wide range of tissues and cell types. The level of activity did not vary significantly with respect to the state of cell differentiation, cell cycle, or transformation. Thus, the unwinding and modifying activity, localized in the nucleus in somatic cells and capable of converting many adenosine residues to inosine, appears to be one of the housekeeping genes.
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania.
R W
RW
Wagner
C
C
Yoo
L
L
Wrabetz
J
J
Kamholz
J
J
Buchhalter
N F
NF
Hassan
K
K
Khalili
S U
SU
Kim
B
B
Perussia
F A
FA
McMorris
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D007288:Inosine / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D009690:Nucleic Acid Conformation; D012330:RNA, Double-Stranded / Q000378:metabolism*; D014018:Tissue Distribution; D014982:Xenopus laevis
D012330:RNA, Double-Stranded; D007288:Inosine