Lymphocyte-derived progesterone-induced blocking factor corrects resorption in a murine abortion system.
An anti-abortive effect of a progesterone-induced blocking factor has been shown in the CBA/J x DBA/2 abortion system. I.p. injections of pregnant mice on days 7.5, 9.5, and 11.5 of gestation with dialyzed supernatants from progesterone-treated murine pregnancy spleen cells (but not from control ones) significantly (P less than 0.01) reduced the resorption rate from 47.7% in the untreated animals to 20.7%.
Institute of Microbiology, University Medical School, Pècs, Hungary.
J
J
Szekeres-Bartho
G
G
Chaouat
D000818:Animals; D001685:Biological Factors / Q000378:metabolism / Q000494:pharmacology*; D016009:Chi-Square Distribution; D020964:Embryo Loss / Q000517:prevention & control*; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
D001685:Biological Factors; D011374:Progesterone