Cardiovascular effects of two potential beta-hydroxylase inhibitors.
The purpose of this study was to evaluate the cardiovascular effects of two potential beta-hydroxylase inhibitors, a dithiocarbamate and a thiourea derivative of d-amphetamine, 1 and 2, respectively. These compounds when given intravenously elicited a significant dose-dependent depressor effect in normotensive rats and dogs anesthetized with chloralose-urethane. The hypotensive effect of these compounds appears to be the result of a combination of two action components: (a) the major component, which can be blocked by atropine, exerted through the parasympathetic division and (b) a decreased availability of sympathetic neurotransmitter at the synaptic cleft. A CNS-stimulant effect of these compounds is suggested by their ability to reduce hexobarbital sleeping time in mice and their analeptic effect in all anesthetized animals employed.
Venugopalan
C S
CS
Jenkins
H J
HJ
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003913:Dextroamphetamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005730:Ganglionic Blockers / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009638:Norepinephrine / Q000378:metabolism; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D005730:Ganglionic Blockers; D010277:Parasympathomimetics; C045991:dextroamphetamine N-dithiocarbamate; C045992:dextroamphetamine N-thiourea; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D003913:Dextroamphetamine; D009638:Norepinephrine