Female predominance of immune response to SSA/Ro antigens and risk of neonatal lupus erythematosus.
Eight-hundred and twenty-five patients attending the hospital with clinical signs and symptoms of collagen diseases were tested for anti-SSA/Ro antibody. The frequency of positivity to SSA/Ro was significantly higher in females, 11.0%, than in males, 3.2% (P less than 0.01). Five babies born to anti-SSA/Ro positive mothers all had neonatal lupus erythematosus and in one there were various cardiac abnormalities.
Department of Dermatology, Nara Medical University, Japan.
S
S
Miyagawa
K
K
Dohi
A
A
Yoshioka
T
T
Shirai
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012307:Risk Factors; D012737:Sex Factors; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies; C035357:SS-B antibodies