Prevention by a new synthetic stable analog of prostacyclin of the gastric lesions due to restraint-cold stress.
A new synthetic stable analog of prostacyclin (ZK 36 374, Iloprost) has been shown to inhibit gastric lesions due to restraint-cold stress in rats in a dose-dependent manner. Therefore substitution of the decreased prostacyclin in the gastric mucosa may play an important role in the prevention or treatment of gastric ulcers.
H
H
Zengil
E
E
Onuk
N
N
Gökok
Z S
ZS
Ercan
R K
RK
Türker
D000818:Animals; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D016285:Iloprost; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000188:drug therapy / Q000517:prevention & control*
D011464:Epoprostenol; D016285:Iloprost