Comparison between extracellular and tissue fluctuation of dopamine and related metabolites in striatum under hypoxia.
The time course of changes in both extracellular and tissue levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum of halothane-anesthetized rats was compared under hypoxic conditions. A 100-fold increase in the extracellular DA was observed within 20 min of hypoxia, while the tissue DA showed a 1.2-fold increase at the maximum. The inhibition of oxygen-dependent enzymes gives no satisfactory explanation for the acute DA increase, the disruption of DA uptake mechanisms may also participate in this.
Masuda
T
T
Department of Anesthesiology, Toyama Medical and Pharmaceutical University, Japan.
Yamazaki
M
M
Ito
Y
Y
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000502:physiology*; D006719:Homovanillic Acid / Q000378:metabolism; D000860:Hypoxia / Q000503:physiopathology*; D007424:Intracellular Fluid / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid