Studies on the plasma kallikrein-kinin system in peritoneal exudate and plasma during experimental acute pancreatitis in pigs.
Acute pancreatitis was induced in pigs by retrograde injection of Na-taurocholate into the pancreatic duct. By means of chromogenic peptide substrate assays, increased plasma kallikrein activity, parallel with a reduction of plasma prekallikrein and functional kallikrein inhibition values, was found in peritoneal exudate. In plasma, however, no changes in the kallikrein-kinin system were found during the 6-h observation time. The study demonstrates the presence of components of the plasma kallikrein-kinin system in peritoneal fluid and suggests that the peritoneal cavity to a great extent is a functionally separate compartment from plasma. Activation of the plasma kallikrein-kinin system in peritoneal exudate during acute experimental pancreatitis appears to be of importance for the initial symptoms and the development of shock seen during this condition.
Ruud
T E
TE
Aasen
A O
AO
Kierulf
P
P
Stadaas
J
J
Aune
S
S
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D005122:Exudates and Transudates / Q000378:metabolism*; D006439:Hemodynamics; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D010195:Pancreatitis / Q000097:blood* / Q000503:physiopathology; D010537:Peritoneum / Q000378:metabolism*; D013552:Swine
D007705:Kinins; D000681:Amylases; D007610:Kallikreins