[Changes in the neuronal activity of the ventrolateral thalamic nucleus and in the motor components of an instrumental reaction in cats following the systemic administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)].
Activity of ventrolateral thalamic neurons during performance of instrumental reaction was studied in four cats before (81 neurons) and after (70 neurons) five injections of MPTP (5 mg/kg every day). It was found that MPTP administration was followed by a clear increase of the discharge frequency of the studied neurons correlated with forelimb movements. The duration of their excitation connected with movement initiation, flexion or extension of limb increased as well. Movement disorders that evidenced for the development of bradykinesia were observed simultaneously with an increase of the neuronal activity. Dophamine microinjection into the caudate nucleus led to recovery of movements and neuronal discharge frequency. A conclusion was made that in intact cats activity of ventrolateral thalamic neurons related to forelimb movements was under inhibitory influences coming from the nigrostriatal system.
V S
VS
Zelenskaia
M Ia
MIa
Voloshin
L V
LV
Okhrimenko
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000172:deficiency; D004576:Electromyography; D008839:Microelectrodes; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013787:Thalamic Nuclei / Q000187:drug effects* / Q000502:physiology
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine
Izmeneniia aktivnosti neĭronov ventrolateral'nogo iadra talamusa i dvigatel'nykh komponentov instrumental'noĭ reaktsii u koshek posle sistemnogo vvedeniia N-metil-4-fenil-1,2,3,6-tetragidropiridina (MFTP).